title: Cystatin C is a suitable marker of glomerular function in children with cancer.
abstract: Antineoplastic chemotherapy is associated with nephrotoxic side effects. Data on nephrotoxicity in childhood cancer are scanty, in part because of the difficulties in obtaining reliable markers of glomerular function. We used serum cystatin C (cysC) to assess glomerular function. CysC was compared with serum creatinine concentration (S(Cr)), the endogenous creatinine clearence ( C(Cr)), and the calculated Counahan formula ( C(Counahan)) in children with leukemia and solid tumors. CysC was measured by particle-enhanced immunoturbidimetric assay. Serum and urinary creatinine concentrations were determined by the Jaffé method. Samples were obtained from 258 children, including 92 receiving anticancer chemotherapy, 108 long-term survivors, 40 children without any renal disease, and 18 patients with chronic renal insufficiency. CysC of patients on current chemotherapy was assessed both before and after treatment. Significant correlations were found between cysC and S(Cr) and between 1/cysC and C( Counahan). CysC increased significantly after cisplatin, methotrexate, cyclophosphamide, ifosfamide, and multimodality treatment. Our results suggest that cysC measurement can be used to characterize glomerular function in children with cancer.
authors.affiliation: Department of Pediatrics, Medical and Health Science Center, University of Debrecen, Hungary. editbardi@hotmail.com
authors.forename: Edit
authors.initials: E
authors.lastname: Bárdi
authors.forename: Ildikó
authors.initials: I
authors.lastname: Bobok
authors.forename: Anna V
authors.initials: AV
authors.lastname: Oláh
authors.forename: Eva
authors.initials: E
authors.lastname: Oláh
authors.forename: János
authors.initials: J
authors.lastname: Kappelmayer
authors.forename: Csongor
authors.initials: C
authors.lastname: Kiss
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002648:Child; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood* / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000209:etiology / Q000378:metabolism; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine