Limited infection upon human exposure to a recombinant raccoon pox vaccine vector.
A laboratory accident resulted in human exposure to a recombinant raccoon poxvirus (RCN) developed as a vaccine vector for antigens of Yersinia pestis for protection of wild rodents (and other animals) against plague. Within 9 days, the patient developed a small blister that healed within 4 weeks. Raccoon poxvirus was cultured from the lesion, and the patient developed antibody to plague antigen (F1) and RCN. This is the first documented case of human exposure to RCN.
Rocke
Tonie E
TE
USGS National Wildlife Health Center, 6006 Schroeder Road, Madison, WI 53711, USA. tonie_rocke@usgs.gov
Dein
F Joshua
FJ
Fuchsberger
Martina
M
Fox
Barry C
BC
Stinchcomb
Dan T
DT
Osorio
Jorge E
JE
D000062:Accidents, Occupational; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D005260:Female; D005822:Genetic Vectors; D006801:Humans; D007753:Laboratories; D051379:Mice; D010930:Plague / Q000276:immunology; D011212:Poxviridae / Q000276:immunology*; D011213:Poxviridae Infections / Q000276:immunology*; D011821:Raccoons; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019444:Vaccines, DNA / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D015010:Yersinia pestis / Q000276:immunology
D000914:Antibodies, Viral; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic; D014765:Viral Vaccines