Facilitative effect of a novel AVP fragment analog, NC-1900, on memory retention and recall in mice.
In order to determine the mechanism of action of a new AVP(4-9) analog, NC-1900, on memory processes, memory retention and retrieval tests were conducted in a step-through passive avoidance (PA) task in mice. The administration of NC-1900 facilitated memory retention and retrieval in the PA task through vasopressin1A (V1A) receptors but not V2 receptors. The effect of NC-1900 on memory retention test performance appeared to be due to activation of the protein kinase C (PKC) signaling pathway via V1A receptors; however, the modulation of PKC was not essential for the facilitative effect of the new peptide in the retrieval test. The facilitation of memory retrieval by NC-1900 may also be mediated by other non-PKC-dependent signaling pathways, such as the phospholipase C-inositol trisphosphate pathway.
Sato
Tomoaki
T
Department of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8, 890-8544, Japan. tomsato@dentb.hal.kagoshima-u.ac.jp
Tanaka
Koh-ichi
K
Teramoto
Toyonori
T
Ohnishi
Yoshiko
Y
Hirate
Kenji
K
Irifune
Masahiro
M
Nishikawa
Takashige
T
D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D020536:Enzyme Activators / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010703:Phorbol Esters / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D011761:Pyrrolidonecarboxylic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D017483:Receptors, Vasopressin / Q000378:metabolism; D013268:Stimulation, Chemical; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D065092:Antidiuretic Hormone Receptor Antagonists; D020536:Enzyme Activators; C115056:NC 1900; D009842:Oligopeptides; D010703:Phorbol Esters; D010880:Piperidines; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; C069701:NPC 15437; C019486:4-O-methyl-phorbol-12,13-didecanoate; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate; D011761:Pyrrolidonecarboxylic Acid