title: Interictal lack of habituation of mismatch negativity in migraine.
abstract: The aim was to study mismatch negativity features and habituation during the interictal phase of migraine. In migraine patients, a strong negative correlation has been found between the initial amplitude of long latency auditory-evoked potentials and their amplitude increase during subsequent averaging. We studied 12 outpatients with a diagnosis of migraine without aura recorded in a headache-free interval and 10 gender- and age-matched healthy volunteers not suffering from any recurrent headache. The experiment consisted of two sequential blocks of 2000 stimulations, during which 1800 (90%) recordings for standard tones and 200 (10%) for target tones were selected for averaging. The latency of the N1 component was significantly increased in migraine patients in respect of controls in both the first and second repetitions; the MMN latency was increased in the second repetition. In the control group the MMN amplitude decreased on average by 3.2 +/- 1.4 microV in the second trial, whereas in migraine patients it showed a slight increase of 0.21 +/- 0.11 microV in the second repetition. The MMN latency relieved in the second trial was significantly correlated with the duration of illness in the migraine patients (Spearman correlation coefficient: 0.69; P < 0.05). The increases in N1 latency and MMN latency and amplitude, the latter correlated with duration of illness, seemed to be due to a reduced anticipatory effect of stimulus repetition in migraine patients. This suggests that such hypo-activity of automatic cortical processes, subtending the discrimination of acoustic stimuli, may be a basic abnormality in migraine, developing in the course of the disease.
authors.affiliation: Department of Neurological and Psychiatric Sciences University of Bari, Italy. m.detommaso@neurol.uniba.it
authors.forename: M
authors.initials: M
authors.lastname: de Tommaso
authors.forename: M
authors.initials: M
authors.lastname: Guido
authors.forename: G
authors.initials: G
authors.lastname: Libro
authors.forename: L
authors.initials: L
authors.lastname: Losito
authors.forename: O
authors.initials: O
authors.lastname: Difruscolo
authors.forename: M
authors.initials: M
authors.lastname: Sardaro
authors.forename: F M
authors.initials: FM
authors.lastname: Puca
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology