Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei.
The presence of bergenin in substantial amounts in the methanol leaves extract of Flueggea virosa (Euphorbiaceae) was established as a strong chemotaxomic point of differentiation between Flueggea virosa and Securinega virosa. Bergenin showed an inhibitory effect on the growth of the bloodstream form of Trypanosoma brucei with an IC50 value of 1 microM.
Nyasse
B
B
Department of Organic Chemistry, Faculty of Science, Higher Teachers Training College, University of Yaoundé I, Cameroon. bnyasse@uycdc.uninet.cm
Nono
J
J
Sonke
B
B
Denier
C
C
Fontaine
C
C
D000818:Animals; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D004791:Enzyme Inhibitors / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D009682:Magnetic Resonance Spectroscopy; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D025221:Phosphofructokinases / Q000037:antagonists & inhibitors; D010735:Phosphoglycerate Kinase / Q000037:antagonists & inhibitors; D018515:Plant Leaves / Q000737:chemistry; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects* / Q000201:enzymology
D001578:Benzopyrans; D004791:Enzyme Inhibitors; D014344:Trypanocidal Agents; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D025221:Phosphofructokinases; D010735:Phosphoglycerate Kinase; C006741:bergenin