[Bupropion-induced epileptic seizures].
BACKGROUND
Bupropion hydrochloride (Zyban) is prescribed for smoking cessation. It is contraindicated in patients with seizure disorders. We report three patients with generalized tonic-clonic seizure that occurred a few days after the intake of this drug.


METHODS
The first two patients had no personal or family seizure history. They had generalized tonic-clonic seizure after taking bupropion (300 mg per day) for a few days. Acute symptomatic seizures were diagnosed in both cases. The third patient suffered from myoclonic jerks during adolescence, had a history of seizure after high dose codeine treatment and a family seizure history. She had generalized tonic-clonic seizure after taking bupropion 300 mg per day. EEG showed paroxystic generalized activity and photosensitivity, consistent with the diagnosis of juvenile myoclonic epilepsy.


CONCLUSIONS
Bupropion can lower seizure threshold. The incidence of seizure at 300 mg per day is 1/1000 patients treated.


CONCLUSIONS
Many commonly prescribed drugs can trigger epileptic seizure, bupropion is one of them. When prescribing this drug, this adverse effect must be acknowledged and health practitioners should be aware of this risk.
Kuate
C
C
Unité Médico-chirurgicale de l'Epilepsie, Hôpital Gui de Chauliac, Montpellier, France.
Gélisse
P
P
Baldy-Moulinier
M
M
Crespel
A
A
D000328:Adult; D016642:Bupropion / Q000008:administration & dosage / Q000009:adverse effects*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*
D018765:Dopamine Uptake Inhibitors; D016642:Bupropion