title: Microwave-assisted parallel synthesis of a 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine library.
abstract: Microwave-assisted parallel synthesis of a library of 20 phenyl dihydrotriazines was successfully achieved and compared to an identical library generated by conventional parallel synthesis. Microwave synthesis dramatically decreased reaction times from an average of 22 h to 35 min, and compounds generated using microwave irradiation were purer. Isolated yields of all the compounds were comparable when the two methods were used.
authors.affiliation: Program in Chemical Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.
authors.forename: Hong-Kee
authors.initials: HK
authors.lastname: Lee
authors.forename: Tariq M
authors.initials: TM
authors.lastname: Rana
mesh_terms: D008872:Microwaves; D015394:Molecular Structure; D013696:Temperature; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: C500294:4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine; D014227:Triazines