title: MR spectroscopy of cervical spinal cord in patients with multiple sclerosis.
abstract: MR spectroscopy (MRS) of the brain in patients with multiple sclerosis has been well studied. However, in vivo MRS of the spinal cord in patients with MR spectroscopy has not been reported to our knowledge. We performed MRS of normal-appearing cervical spinal cords in multiple sclerosis patients and in healthy controls. N-acetyl aspartate was shown to be reduced within the cervical spinal cord of multiple sclerosis patients when compared with healthy controls. This finding supports axonal loss and damage within even normal-appearing spinal cords of multiple sclerosis patients.
authors.affiliation: Radiology Department, Kirikkale University School of Medicine, Kirikkale, Turkey. drtubakendi@yahoo.com
authors.forename: Ayşe Tuba Karagülle
authors.initials: AT
authors.lastname: Kendi
authors.forename: Funda Uysal
authors.initials: FU
authors.lastname: Tan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kendi
authors.forename: Sevda
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Sinef
authors.initials: S
authors.lastname: Huvaj
authors.forename: Serdar
authors.initials: S
authors.lastname: Tellioğlu
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D016022:Case-Control Studies; D002574:Cervical Vertebrae; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology; D013116:Spinal Cord / Q000378:metabolism* / Q000473:pathology
chemical_list: D001224:Aspartic Acid; D019344:Lactic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline