title: Drug-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: a concise review.
abstract: An extensive variety of drugs have been associated with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP/HUS). Although a direct causal effect has usually not been proven, the cumulative evidence linking several drugs with TTP/HUS is strong. This paper reviews several categories of drugs including antineoplastics, immunotherapeutics and anti-platelet agents that have been reported to induce TTP/HUS. The pathogenesis of drug-induced TTP/HUS and the effectiveness of treatment regimens are also reviewed. A consensus on diagnostic criteria to accurately and consistently diagnose drug-induced TTP is needed.
authors.affiliation: Department of Pathology and Laboratory Medicine (Transfusion Medicine), Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Dlott
authors.forename: Constance F M
authors.initials: CF
authors.lastname: Danielson
authors.forename: Deborah E
authors.initials: DE
authors.lastname: Blue-Hnidy
authors.forename: Leo J
authors.initials: LJ
authors.lastname: McCarthy
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D010975:Platelet Aggregation Inhibitors