title: Inhibitory effect of medicinal herbs against RNA and DNA viruses.
abstract: Fifteen Argentine medicinal plants were tested for their antiviral activity in vitro against herpes simplex viruses types 1 and 2 (HSV-1 and 2), bovine viral diarrhoea virus type 1 (BVDV-1), influenza virus type A (Inf A) and human immunodeficiency virus type 1 (HIV-1). Antiviral activity was evaluated by a reduction in cytopathic effect, plaque-forming units and p24 HIV-1 antigen. The Selective Index of the active extract (SI(extract) = CC50(extract)/EC50(extract)) of Coronopus didymus (SI(extract) = 110.7), Juglans australis (SI(extract) = 8.1) and Lippia alba (SI(extract) = 19.2) against BVDV-1, HSV-1 and influenza A virus, respectively, justify a further analysis. None of the seven plants assayed against HIV-1 displayed any antiviral activity. The results of this study justify the continuing isolation and characterization of the antiviral components present.
authors.affiliation: Universidad de Buenos Aires, Argentina.
authors.forename: María Julieta
authors.initials: MJ
authors.lastname: Ruffa
authors.forename: Marcelo Luis
authors.initials: ML
authors.lastname: Wagner
authors.forename: Mónica
authors.initials: M
authors.lastname: Suriano
authors.forename: Carlos
authors.initials: C
authors.lastname: Vicente
authors.forename: Jelena
authors.initials: J
authors.lastname: Nadinic
authors.forename: Sandra
authors.initials: S
authors.lastname: Pampuro
authors.forename: Horacio
authors.initials: H
authors.lastname: Salomón
authors.forename: Rodolfo Héctor
authors.initials: RH
authors.lastname: Campos
authors.forename: Lucía
authors.initials: L
authors.lastname: Cavallaro
mesh_terms: D000818:Animals; D001118:Argentina; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000188:drug therapy*; D002417:Cattle; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D018139:Simplexvirus / Q000187:drug effects; D014709:Vero Cells; D010948:Viral Plaque Assay
chemical_list: D010936:Plant Extracts