Scleroderma and the taxanes. Is there really a link?
Scleroderma has been associated with exposure to many substances in the past ranging from vinyl chloride to silicon dioxide. In recent years there have been a number of case reports linking modern chemotherapy agents, such as the taxanes to the development of scleroderma like changes. We present a further case of scleroderma in association with chemotherapy but question the role of some of the agents previously implicated. A brief review of the current literature is included.
Farrant
P B J
PB
Department of Dermatology, St George's Hospital, The Royal Marsden Hospital, London, UK. drpaulfarrant@doctors.org.uk
Mortimer
P S
PS
Gore
M
M
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel