Lysosomal redox-active iron is important for oxidative stress-induced DNA damage.
Data show that specifically chelating lysosomal redox-active iron can prevent most H(2)O(2)-induced DNA damage. Lysosomes seem to contain the major pool of redox-active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage by taking part in Fenton reactions.
Kurz
Tino
T
School of Clinical Medical Sciences-Gerontology, University of Newcastle upon Tyne, Newcastle General Hospital, Henry Wellcome Laboratory for Biogerontology Research, NE4 6BE, United Kingdom. tino.kurz@ncl.ac.uk
Leake
Alan
A
von Zglinicki
Thomas
T
Brunk
Ulf T
UT
D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D004249:DNA Damage; D003676:Deferoxamine / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D016615:Telomere / Q000648:ultrastructure
D007502:Iron Chelating Agents; D006861:Hydrogen Peroxide; D007501:Iron; D003676:Deferoxamine