[Amoxicillin in tonsillectomy: preliminary data on the evaluation of serum and tissue concentrations].
Amoxicillin was administered to 50 patients with chronic recurrent tonsillitis waiting for tonsillectomy. Group A (N=16) received 2.2 g of amoxicillin plus clavulanic acid with intravenous injection 10 minutes before tonsillectomy Group B (N=34) was treated with 3 doses of amoxicillin-clavulanic acid administered orally the day before surgery, plus one oral administration 2 hours before tonsillectomy. Antibiotic doses were established on patient's weight using maximum suggested. The measures were, estimated in serum and in tonsils using High Performance Liquid Chromatography, (HPLC). The data show better efficacy of intravenous administration than oral administration.
Averono
Gianluca
G
Clinica Otorinolaringoiatrica, Università degli Studi del Piemonte Orien- tale Amedeo Avogadro, Novara.
Olina
Massimo
M
Basile
Matteo
M
Bagnati
Marco
M
Uglietti
Alessia
A
Garavelli
Pietro Luigi
PL
Bellomo
Giorgio
G
Pia
Francesco
F
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019072:Antibiotic Prophylaxis / Q000379:methods; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014018:Tissue Distribution; D014068:Tonsillectomy; D014069:Tonsillitis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism* / Q000601:surgery; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D000658:Amoxicillin