title: Intraoperative fluid management of living donor versus cadaveric liver transplant recipients.
abstract: Living donor liver transplantation has increasingly become an alternative to cadaveric donor liver transplants for select adult patients. Because these cases can be performed electively, living donor recipients may have better compensated liver disease at the time of surgery than cadaver donor recipients. However, it is unknown if this difference would have a significant effect on their intraoperative course. Therefore, we compared the intraoperative fluid management of patients receiving liver grafts from either living or cadaveric donors (n = 25, each group). Patient groups did not differ in demographics or baseline laboratory values. The duration of anesthesia and anhepatic phases were significantly longer in living donor cases (651 +/- 80 minutes vs 409 +/- 20 and 55 +/- 14 vs 45 +/- 6, P < .05). Adjusted for anesthesia time and patient weight, fluid administration (crystalloid and albumin) was not different between the two groups. Intraoperative transfusion requirements were also not significantly different in recipients from living donors versus cadaveric donors with regard to red blood cells, fresh frozen plasma, platelets, and cryoprecipitate. However, arterial oxygenation was better preserved in recipients from living donors. The PaO2/FiO2 (P/F) ratio at the end of the procedure was significantly better in patients receiving livers from living rather than from cadaveric donors (P/F ratio 335 +/- 114 mm Hg vs 271 +/- 174, P < .05). Our results indicate that while intraoperative fluid and transfusion requirements are similar, the impact of transplantation on pulmonary gas exchange is more pronounced in patients receiving organs from cadaveric donors. This difference may arise from longer cold ischemia times present in the cadaveric donor group.
authors.affiliation: Anesthesia and Perioperative Care, University of California San Francisco, 94143, USA.
authors.forename: C U
authors.initials: CU
authors.lastname: Niemann
authors.forename: R
authors.initials: R
authors.lastname: Hirose
authors.forename: P
authors.initials: P
authors.lastname: Stock
authors.forename: J P
authors.initials: JP
authors.lastname: Roberts
authors.forename: S
authors.initials: S
authors.lastname: Mandell
authors.forename: C
authors.initials: C
authors.lastname: Spencer Yost
mesh_terms: D002102:Cadaver; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007430:Intraoperative Care; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011184:Postoperative Period; D012189:Retrospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D010100:Oxygen