title: Toxicity of PCB 1232 on mitochondria of fish Arius caelatus (Valenciennes).
abstract: Mitochondrial proteins and phospholipids were estimated and SDH, Na(+)-K(+)-ATPase and Mg(2+)-ATPase activities were analysed in the gill, liver and heart tissues of PCB 1232 (sublethal doses) treated fish A. caelatus. Protein and phospholipids were found to be decreased significantly and SDH, Na(+)-K(+)-ATPase, Mg(2+)-ATPase and other enzyme systems displayed an inverse relationship with PCB dosage. Statistical analysis was carried out to indicate the relationship between sublethal doses of varying concentration and the activities of the enzyme systems involved in energy metabolism. The studies indicated impairment in mitochondrial functions.
authors.affiliation: Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai 625 021, India.
authors.forename: Dravyam
authors.initials: D
authors.lastname: Selvarani
authors.forename: C
authors.initials: C
authors.lastname: Rajamanickam
mesh_terms: D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D002397:Catfishes / Q000378:metabolism*; D004734:Energy Metabolism; D005880:Gills / Q000187:drug effects / Q000201:enzymology; D006321:Heart / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; D010743:Phospholipids; D011078:Polychlorinated Biphenyls; D013385:Succinate Dehydrogenase; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase