HIV and drug allergy.
Twenty individual antiretroviral drugs and two coformulation products are approved by the US Food and Drug Administration for the treatment of HIV-infected individuals. Many of these drugs have been associated with allergic/hypersensitivity reactions to varying degrees. The antiretroviral drugs that are most commonly associated with these types of reactions are abacavir, all of the nonnucleoside reverse transcriptase inhibitors, and amprenavir. Trimethoprim-sulfamethoxazole, although not an antiretroviral drug, is extensively used for the treatment and prophylaxis of HIV-related opportunistic infections and has been associated with a significant rate of adverse reactions. The authors provide an overview of these drug-related reactions and discuss their pathogenesis and management.
Temesgen
Zelalem
Z
Division of Infectious Diseases, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. temesgen.zelalem@mayo.edu
Beri
Gagan
G
D000998:Antiviral Agents / Q000009:adverse effects* / Q000276:immunology* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000276:immunology* / Q000503:physiopathology*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans
D000998:Antiviral Agents