title: HIV type 1 and cytomegalovirus coinfection in the female genital tract.
abstract: The relationship between human immunodeficiency virus (HIV) type 1 and human cytomegalovirus (CMV) was studied in blood, saliva, and cervicovaginal lavage (CVL) specimens from 33 HIV-1-infected women. An association between HIV-1 RNA and CMV DNA was found in the CVL specimens, which also were tested for cytokine levels. Women with detectable CMV DNA in CVL specimens were more likely to have higher interleukin (IL)-1 beta and IL-8 levels than were women with undetectable CMV DNA in CVL specimens. More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression.
authors.affiliation: Rush University Medical Center, Chicago, Illinois 60612, USA. nlurain@rush.edu
authors.forename: Nell S
authors.initials: NS
authors.lastname: Lurain
authors.forename: Emmanuel S
authors.initials: ES
authors.lastname: Robert
authors.forename: Jiahong
authors.initials: J
authors.lastname: Xu
authors.forename: Margaret
authors.initials: M
authors.lastname: Camarca
authors.forename: Alan
authors.initials: A
authors.lastname: Landay
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Kovacs
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Reichelderfer
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000821:virology; D015331:Cohort Studies; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis / Q000097:blood; D005260:Female; D005831:Genital Diseases, Female / Q000821:virology*; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D012367:RNA, Viral / Q000032:analysis / Q000097:blood; D012463:Saliva / Q000821:virology; D007507:Therapeutic Irrigation / Q000379:methods; D014621:Vagina / Q000821:virology
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral