title: Design and synthesis of cyclic urea compounds: a pharmacological study for retinoidal activity.
abstract: Retinoids are natural and synthetic analogues of all-trans retinoic acid (ATRA). Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids. We report here the design and synthesis of novel cyclic urea compounds with retinoidal activity. YR105 exhibited potent differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells at the concentration of 10(-9)M: its potency was almost equal to that of the native ligand, all-trans retinoic acid.
authors.affiliation: Division of Organic Chemistry, National Institute of Health Sciences, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. masaaki@nihs.go.jp
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kurihara
authors.forename: Abu Shara Shamsur
authors.initials: AS
authors.lastname: Rouf
authors.forename: Hisao
authors.initials: H
authors.lastname: Kansui
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kagechika
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Okuda
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyata
mesh_terms: D018922:HL-60 Cells; D006801:Humans; D008958:Models, Molecular; D012176:Retinoids / Q000494:pharmacology*; D014508:Urea / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D012176:Retinoids; D014508:Urea