Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection.
Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection and were correlated with HSV load. It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection.
Kawada
Jun-ichi
J
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kimura
Hiroshi
H
Ito
Yoshinori
Y
Ando
Yoshihiro
Y
Tanaka-Kitajima
Naoko
N
Hayakawa
Masahiro
M
Nunoi
Hiroyuki
H
Endo
Fumio
F
Morishima
Tsuneo
T
D017209:Apoptosis; D000068800:Etanercept; D006561:Herpes Simplex / Q000276:immunology* / Q000401:mortality / Q000503:physiopathology* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000276:immunology / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D015850:Interleukin-6 / Q000097:blood; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D018139:Simplexvirus / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D019562:Viral Load
D007074:Immunoglobulin G; D015850:Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D000068800:Etanercept