title: Synthesis of chiral 13C,77Se-labeled selones.
abstract: Stable isotope-labeled N-acyl selones have been constructed in fewer than four steps from readily available starting materials. Site-specific labeling was achieved using the following synthons: bromo[2-(13)C]acetic acid, [(13)C]formic acid, and elemental (77)Se. These labeled selones have been found to provide unique insights into enolate structure and may be useful in the detection and quantitation of remotely disposed chiral centers in compounds in short supply.
authors.affiliation: Los Alamos National Laboratory, Bioscience Division, the Biotechnology, Spectroscopy, and Isotope Chemistry group (B-SIC), NIH National Stable Isotope Resource, MS E529, Los Alamos, NM 87545, USA. pete-silks@lanl.gov
authors.forename: Morgane
authors.initials: M
authors.lastname: Ollivault-Shiflett
authors.forename: David B
authors.initials: DB
authors.lastname: Kimball
authors.forename: L A Pete
authors.initials: LA
authors.lastname: Silks
mesh_terms: D002247:Carbon Isotopes; D007554:Isotopes; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018036:Selenium Compounds / Q000737:chemistry*
chemical_list: D002247:Carbon Isotopes; D007554:Isotopes; D018036:Selenium Compounds