Malignant evolution of monoclonal gammopathy of undetermined significance: analysis of 633 consecutive cases with a long term follow-up.
In 633 consecutive patients with monoclonal gammopathy of undetermined significance (MGUS) the probability of malignant evolution was 9, 17 and 51 % at 5, 10 and 15 years, respectively, after diagnosis. The values of monoclonal component, Bence-Jones proteinuria and erythrocyte sedimentation rate were associated with malignant transformation.
Veneri
Dino
D
Aqel
Haytham
H
Franchini
Massimo
M
Krampera
Mauro
M
Zanotti
Roberta
R
Pizzolo
Giovanni
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000453:epidemiology / Q000473:pathology*; D013997:Time Factors