Characterization and in vitro degradation of poly(2,3-(1,4-diethyl tartrate)-co-2,3-isopropyliden tartrate).
In the present study, a less known polyester based on tartaric acid was characterized with respect to its degradation mechanism. Poly(2,3-(1,4-diethyl tartrate)-co-2,3-isopropyliden tartrate) (PTA) differs from commonly used biodegradable polyesters, such as poly(lactides-co-glycolides) (PLGA) by the presence of additional cleavable bonds in the polymer side chains. This modification results in different polymer properties and influences polymer degradation. The hydrolytic degradation of PTA was studied in parallel to PLGA using disc-shape matrices, which were obtained by compression-molding. The discs were incubated in pH 7.4 phosphate buffer solution at 37 degrees C. The degraded samples were characterized for percentage mass loss, water absorption, decay of molecular weight and change in glass transition temperature. The results demonstrate that the degradation of PTA proceeds via bulk erosion similar to PLGA. However, the degradation of PTA implants is characterized by a rapid mass loss within a short period of time appearing after a definite lag phase without remarkable mass loss. This makes the polymer promising for pulsatile drug release systems.
Schliecker
Gesine
G
Department of Pharmaceutics and Biopharmacy, University of Marburg, Germany.
Schmidt
Carsten
C
Fuchs
Stefan
S
Kissel
Thomas
T
D000475:Alkenes / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*; D013644:Tartrates / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*
D000475:Alkenes; D013644:Tartrates; C013658:propylene; C029768:tartaric acid