Inositol and phosphatidylinositol mediated mediated glucose derepression, gene expression and invertase secretion in yeasts.
Glucose repression occurs in many yeast species and some filamentous fungi, and it represses the expression and secretion of many intracellular and extracellular proteins. In recent years, it has been found that many biochemical reactions in yeast cells are mediated by phosphatidylinositol (PI)-type signaling pathway. However, little is known about the relationships between PI-type signaling and glucose repression, gene expression and invertase secretion in yeasts. Many evidences in our previous studies showed that glucose repression, invertase secretion, gene expression and cell growth were mediated by inositol and PI in Saccharomyces and Schizosaccharomyces. The elucidation of the new regulatory mechanisms of protein secretion, gene expression and glucose repression would be an entirely new aspect of inositol and PI-type signaling regulation in yeasts.
Chi
Zhen-Ming
ZM
UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Qingdao 266003, China. zhenming@sdu.edu.cn
Li
Jun-Feng
JF
Wang
Xiang-Hong
XH
Yao
Shu-Min
SM
D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D007294:Inositol / Q000502:physiology*; D010716:Phosphatidylinositols / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D010716:Phosphatidylinositols; D007294:Inositol; D005947:Glucose