title: A novel compression-coated doughnut-shaped tablet design for zero-order sustained release.
abstract: A novel coated doughnut-shaped tablet is evaluated as to its ability to be manufactured in a reproducible manner, and as to whether it releases model drugs at a zero-order rate. The doughnut-shaped tablets were compressed using specially designed punches, which make automated production feasible. In the preliminary part of the experiment, HPMC K15M mixed with gelatin was found to be the most suitable coating tablet material with respect to its disintegration and adherence properties. The adherence of the coating tablet to ibuprofen cores was not optimal, so different concentrations of gelatin, to act as a plasticiser and enhance adherence, were further investigated. Friability results of the coated doughnut-shaped tablet indicate that coating tablets containing 20% and 30% gelatin had a percentage weight losses of less than 1% after 100 revolutions in a Roche friabilator. For all the concentrations of gelatin, the granule blends had angle of repose values in the range of 22.01-17.8 degrees. The compressibility factor, as measured from the slopes of the natural logarithm of compressional force versus crushing strength, were 121.91 +/- 2.36, 132.64 +/- 3.60, and 88.54 +/- 11.52 for the coating tablet granules containing 10%, 20%, and 30% gelatin in HPMC K15M, respectively. The composition of the coating tablet did not affect the rate of release of both caffeine and ibuprofen from the coated doughnut-shaped tablets. The coatings also adhered to the core tablets for the entire duration of the release of the drugs.
authors.affiliation: Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Rd, Parktown, 2193 Johannesburg, South Africa.
authors.forename: Erica
authors.initials: E
authors.lastname: Sundy
authors.forename: Michael Paul
authors.initials: MP
authors.lastname: Danckwerts
mesh_terms: D019245:Compressive Strength; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics*; D006244:Hardness; D013608:Tablets, Enteric-Coated
chemical_list: D003692:Delayed-Action Preparations; D013608:Tablets, Enteric-Coated