title: Hepatitis C virus infection as a likely etiology of intrahepatic cholangiocarcinoma.
abstract: Although hepatitis C virus (HCV)-related cirrhosis has been suggested as a risk factor for intrahepatic cholangiocarcinoma (ICC), few sizeable studies have tested this hypothesis. We investigated ICC risk factors, with special reference to HCV infection. We conducted a hospital-based case-control study including 50 ICC patients and 205 other surgical patients without primary liver cancer. HCV seropositivity was detected in 36% of ICC patients and 3% of controls. By univariate analysis, the odds ratio (OR) for association of anti-HCV antibodies with development was 16.87 (95% confidence interval (CI), 5.69 to 50.00). History of blood transfusion or diabetes mellitus, elevated serum total bilirubin, elevated aspartate aminotransferase and alanine aminotransferase, decreased serum albumin and decreased platelet count were identified as other possible ICC risk factors. By multivariate analysis, anti-HCV antibodies (adjusted OR, 6.02; 95% CI, 1.51 to 24.1), elevated alanine aminotransferase, decreased serum albumin, and decreased platelet count were found to be independent risk factors for ICC development. As liver status worsened, the adjusted OR for ICC tended to increase. HCV infection is a likely etiology of ICC in Japan.
authors.affiliation: Department of Gastroenterological and Hepato-Biliary-Pancreatic Surgery and Public Health, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan. m7577175@msic.med.osaka-cu.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Kubo
authors.forename: Seikan
authors.initials: S
authors.lastname: Hai
authors.forename: Takahiro
authors.initials: T
authors.lastname: Uenishi
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Taichi
authors.initials: T
authors.lastname: Shuto
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Takemura
authors.forename: Hiromu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamazaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hirohashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D016022:Case-Control Studies; D018281:Cholangiocarcinoma / Q000209:etiology / Q000821:virology*; D018450:Disease Progression; D005260:Female; D016174:Hepacivirus / Q000276:immunology / Q000472:pathogenicity*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000821:virology*; D008113:Liver Neoplasms / Q000209:etiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D000914:Antibodies, Viral