Relevance of genetically determined host factors to the prognosis of meningococcal disease.
To assess the relevance of genetically determined host factors for the prognosis of meningococcal disease, Fc gamma receptor IIA (FcgammaRIIA), the tumor necrosis factor alpha (TNF-alpha) gene promoter region, and plasminogen-activator-inhibitor-1 (PAI-1) gene polymorphisms were studied in 145 patients with meningococcal disease and in 290 healthy controls matched by sex. Distribution of FcgammaRIIA, TNF-alpha, and PAI-1 alleles was not significantly different between patients and controls. Patients with the FcgammaRIIA-R/R 131 allotype scored > or =1 point in the Barcelona prognostic system more frequently than patients with other allotypes (odds ratio, 18.6; 95% confidence interval, 7.1-49.0, P<0.0001), and they had a higher risk of sequelae (odds ratio, 3.5; 95% confidence interval, 1.1-11.7; P=0.03). Fc gamma receptor IIA polymorphism was associated with markers of disease severity, but TNF-alpha and PAI-1 polymorphisms were not.
Domingo
P
P
Infectious Diseases Unit, Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avenida Sant Antoni Ma. Claret 167, 08025 Barcelona, Spain. pere.domingo@uab.es
Muñiz-Diaz
E
E
Baraldès
M A
MA
Arilla
M
M
Barquet
N
N
Pericas
R
R
Juárez
C
C
Madoz
P
P
Vázquez
G
G
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008589:Meningococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011336:Probability; D011379:Prognosis; D011401:Promoter Regions, Genetic; D017452:Receptors, IgG / Q000235:genetics* / Q000378:metabolism; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism
D015703:Antigens, CD; C080568:Fc gamma receptor IIA; D005819:Genetic Markers; D017395:Plasminogen Activator Inhibitor 1; D017452:Receptors, IgG; D014409:Tumor Necrosis Factor-alpha