The effects of endurance training in persons with a hereditary myosin myopathy.
OBJECTIVE
To evaluate muscle performance and its consequences in eight individuals with a hereditary myopathy and the effects of an 8-week endurance training program.


METHODS
Handgrip, muscle strength and endurance and oxygen consumption by breath-by-breath analysis during a stepless bicycle ergonometer test were evaluated. Walking, balance test and activities of daily living (ADL) were assessed, and a questionnaire for activity level and perceived symptoms was used. The design was a before-after trial in comparison with data from a control population, bicycling at 70% of maximal workload, 30 min/day, 5 days/week for 8 weeks.


RESULTS
The subjects were weaker than age-matched controls. After training, the peak watt increased by almost 20% (P < 0.05). Muscle strength (flexion/extension) and isometric endurance (40% of maximum at 60 degrees ) did not change significantly. The average self-selected walking speed increased significantly (P < 0.05) from 1.25 to 1.45 m/s. Compliance was excellent and no serious adverse events occurred.


CONCLUSIONS
Endurance training seems to function for this myopathy.
Sunnerhagen
K S
KS
Department of Clinical Neuroscience-Rehabilitation Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. ks.sunnerhagen@neuro.gu.se
Darin
N
N
Tajsharghi
H
H
Tasjharghi
H
H
Oldfors
A
A
D000328:Adult; D005080:Exercise Test; D005081:Exercise Therapy; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D009135:Muscular Diseases / Q000235:genetics* / Q000503:physiopathology / Q000534:rehabilitation*; D024507:Nonmuscle Myosin Type IIA / Q000235:genetics*; D010807:Physical Endurance; D016896:Treatment Outcome
D024507:Nonmuscle Myosin Type IIA