Localized linear IgA disease induced by ampicillin/sulbactam.
We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.
Shimanovich
Iakov
I
Department of Dermatology, University of Würzburg, Germany.
Rose
Christian
C
Sitaru
Cassian
C
Bröcker
Eva-B
EB
Zillikens
Detlef
D
D000368:Aged; D000667:Ampicillin / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000139:chemically induced*; D001706:Biopsy; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D000071821:Dystonin; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology; D013407:Sulbactam / Q000009:adverse effects*; D000097805:Collagen Type XVII
D000667:Ampicillin; D000900:Anti-Bacterial Agents; D001323:Autoantibodies; D001324:Autoantigens; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D007070:Immunoglobulin A; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D013407:Sulbactam; D000097805:Collagen Type XVII; C486268:DST protein, human; C035444:sultamicillin