Impact of serological methodology on assessment of the link between Chlamydia pneumoniae and vascular diseases.
We assessed the impact of five serologic tests on the link between Chlamydia pneumoniae and abdominal aortic aneurysms (AAA). The results of the tests were inconsistent. Agreement among the five tests was generally poor. Detection of the link between C. pneumoniae and AAA depends on the serologic methodology chosen.
Maraha
Boulos
B
Regional Laboratory for Medical Microbiology, Dordrecht, The Netherlands. b.maraha@asz.nl
den Heijer
Martin
M
Kluytmans
Jan
J
Peeters
Marcel
M
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D017544:Aortic Aneurysm, Abdominal / Q000382:microbiology*; D016022:Case-Control Studies; D023521:Chlamydophila Infections / Q000150:complications* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000592:standards; D005260:Female; D005455:Fluorescent Antibody Technique / Q000592:standards; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D015203:Reproducibility of Results; D012698:Serologic Tests / Q000592:standards*; D014652:Vascular Diseases / Q000382:microbiology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G