Factors affecting haemorrhagic transformation in middle cerebral artery infarctions.
OBJECTIVE
Haemorrhagic transformation (HT) affects treatment and prognosis in patients with acute ischaemic stroke. The factors affecting haemorrhagic transformation in infarcts due to occlusion of middle cerebral artery (MCA) stem or branch were investigated.


METHODS
Of 412 patients who were followed in our clinic between January 2001 and December 2001 with acute ischaemic stroke, 86 patients with occlusion in MCA stem or branch were enrolled in this study. These patients were divided into 2 groups, those with HT (n = 35) and without HT (n = 51). Age, sex, systemic arterial hypertension, diabetes mellitus, blood glucose level in the acute period, renal and liver function tests, systolic and diastolic arterial blood pressure in the acute period, previous cerebrovascular disease, leukoaraiosis, modified Rankin Disability Score (mRDS) and stroke subtype were evaluated.


RESULTS
High blood glucose level in the acute period and presence of leukoaraiosis on cranial computerized (CCT) tomography were detected as risk factors in development of HT. HT was seen more frequently in MCA stem infarction than branch infarction. mRDS were worse in the group with HT. In multivariate analysis, there were independent relationships between mean blood glucose level on admission, mRDS, presence of diabetes mellitus, and MCA stem infarction and development of haemorrhagic transformation in patients with MCA territorial infarction.
Celik
Yahya
Y
Neurology Department, Trakya University School of Medicine, Edirne, Turkey. celikyahyatr@yahoo.com
Utku
Ufuk
U
Asil
Talip
T
Balci
Kemal
K
D000368:Aged; D001786:Blood Glucose; D002545:Brain Ischemia / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000145:classification / Q000209:etiology*; D003920:Diabetes Mellitus; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension; D020244:Infarction, Middle Cerebral Artery / Q000150:complications*; D049292:Leukoaraiosis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
D001786:Blood Glucose