title: Effects of prolonged nitrous oxide exposure on hemopoietic stem cells in mice.
abstract: The effects of prolonged exposure to nitrous oxide on the hemopoietic progenitor cells in bone marrow and spleen in mice were investigated. Fifty percent nitrous oxide caused a marked decrease in the number of pluripotent stem cells (CFU-S) and granulocyte-macro-phage progenitor cells (GM-CFC) in the spleen, whereas it caused only a slight decrease in these cells in the bone marrow. These results suggest that prolonged exposure to nitrous oxide induces damage in the splenic hemopoiesis in mice.
authors.affiliation: Department of Anesthesiology, Iwate Medical University, Morioka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Konno
authors.forename: T
authors.initials: T
authors.lastname: Kirikae
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: K J
authors.initials: KJ
authors.lastname: Mori
authors.forename: R
authors.initials: R
authors.lastname: Wakusawa