title: Retinal blood flow measurements and neuroretinal rim damage in glaucoma.
abstract: OBJECTIVE
  To assess retinal blood flow characteristics in subjects with normal tension glaucoma (NTG), primary open angle glaucoma (POAG), and a group of controls using the Heidelberg retina flowmeter (HRF). The vascular parameters were correlated against structural damage of the optic nerve head, assessed using the Heidelberg retina tomograph (HRT).
  
  
  METHODS
  HRF images were obtained in 76 subjects with NTG, 58 with POAG, and 38 controls. Optic nerve head images, acquired using the HRT, were analysed with Moorfields Regression Analysis software. The HRF variables, measured adjacent to a rim segment identified as "abnormal," were compared with the vascular parameters of the "normal" rim segments. The HRF parameters of the segments identified as normal in glaucoma subjects were compared with matched control segments.
  
  
  RESULTS
  The glaucoma subjects had significantly lower retinal haemodynamics than the control subjects. There were no significant differences in the HRF parameters between the NTG and POAG subjects. The discs that had been identified as having abnormal segments had lower HRF values than those with a corresponding normal segment. The glaucoma subjects with normal rim segments had statistically significant lower velocity, flow, and volume measurements than the controls for each location sampled.
  
  
  CONCLUSIONS
  This study shows a relation between structural damage of the optic nerve head and the level of retinal blood flow. The changes in the circulation could indicate that it may be an early marker of the pathological process.
authors.affiliation: Department of Ophthalmology, The Royal Group of Hospitals, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK. joanne.logan1@btopenworld.com
authors.forename: J F J
authors.initials: JF
authors.lastname: Logan
authors.forename: S J A
authors.initials: SJ
authors.lastname: Rankin
authors.forename: A J
authors.initials: AJ
authors.lastname: Jackson
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D005260:Female; D045268:Flowmeters; D005901:Glaucoma / Q000503:physiopathology*; D005902:Glaucoma, Open-Angle / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009898:Optic Disk / Q000473:pathology*; D012039:Regional Blood Flow / Q000502:physiology; D012171:Retinal Vessels / Q000503:physiopathology*; D014054:Tomography / Q000379:methods