title: Mortality from chronic obstructive pulmonary disease and pleural mesothelioma in an area contaminated by natural fiber (fluoro-edenite).
abstract: OBJECTIVE
  The purpose of the present study was to investigate the association between mortality from chronic obstructive pulmonary disease (COPD) and exposure to fluoro-edenite, a newly discovered amphibolic fiber found in Biancavilla (Sicily), a municipality on the slope of the Etna volcano, where a high mortality from malignant mesothelioma had been previously observed.
  
  
  METHODS
  Thirty-six municipalities located in the volcanic area of mount Etna were selected for study. An ecological regression model was applied with mortality from COPD as the dependent variable, mortality from mesothelioma as a proxy for exposure to fluoro-edenite, and lung cancer mortality, an urban-rural index, a deprivation index and an aging index as the predictors of COPD mortality. For each municipality, risk classes were determined for the continuous variables with the use of a finite mixture model.
  
  
  RESULTS
  A significant association was found between COPD mortality and pleural neoplasm mortality among the women in this study. The association was less consistent for the men.
  
  
  CONCLUSIONS
  Despite the limitations of this ecological study, the results cohere with the results of toxicologic and observational studies and suggest an etiologic role for fluoro-edenite in nonmalignant respiratory diseases.
authors.affiliation: Department of Statistics, University of Florence, Florence, Italy.
authors.forename: Annibale
authors.initials: A
authors.lastname: Biggeri
authors.forename: Roberto
authors.initials: R
authors.lastname: Pasetto
authors.forename: Stefano
authors.initials: S
authors.lastname: Belli
authors.forename: Caterina
authors.initials: C
authors.lastname: Bruno
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Maria
authors.forename: Marina
authors.initials: M
authors.lastname: Mastrantonio
authors.forename: Stefania
authors.initials: S
authors.lastname: Trinca
authors.forename: Raffaella
authors.initials: R
authors.lastname: Uccelli
authors.forename: Pietro
authors.initials: P
authors.lastname: Comba
mesh_terms: D000328:Adult; D000368:Aged; D015982:Bias; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000209:etiology* / Q000401:mortality*; D008875:Middle Aged; D019016:Mineral Fibers / Q000633:toxicity*; D010997:Pleural Neoplasms / Q000209:etiology* / Q000401:mortality*; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000401:mortality*; D012044:Regression Analysis; D012307:Risk Factors; D012423:Rural Health; D012737:Sex Factors; D012802:Sicily / Q000453:epidemiology; D014504:Urban Health; D018707:Volcanic Eruptions / Q000032:analysis
chemical_list: D019016:Mineral Fibers