Effects of cantharidinimides on human carcinoma cells.
Modification of the cantharidinimide structure led to the discovery of a novel class of antitumor compounds. These cantharidinimide derivatives containing aliphartic, aryl, and pyridyl groups showed some effect in vitro against HepG2 and HL-60 cells.
Lin
Lun-Huei
LH
Department of Medicinal Chemistry, Taipei Medical University School of Pharmacy, Taiwan.
Huang
Hsu-Shan
HS
Lin
Chiung-Chang
CC
Lee
Lin-Wen
LW
Lin
Pen-Yuan
PY
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002193:Cantharidin / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D001517:Coleoptera; D006801:Humans; D007094:Imides / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007094:Imides; D002193:Cantharidin