Identification of a new HLA-DRB1 allele in three members of an Italian family.
Abstract A new human leucocyte antigen (HLA)-DRB1 allele, HLA-DRB1*1149, has been identified in three members of an Italian family during routine sequence based typing. This new allele differs from HLA-DRB1*110101 only for a single nucleotide substitution at position 113 of exon 2 resulting in an amino acid change from Valine (GTG) to Alanine (GCG) at codon 38.
Garino
E
E
Transplantation Immunology, San Giovanni Battista Hospital of Turin, Italy. egarino@molinette.piemonte.it
Berrino
M
M
Mazzola
G
G
Boccadoro
M
M
Bruno
B
B
Bertinetto
F
F
Bertola
L
L
Caropreso
P
P
Frisaldi
E
E
Marin
F
F
Panniello
M L
ML
Tondat
F
F
Dall'Omo
A M
AM
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001483:Base Sequence; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007558:Italy; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen