title: Influence of haematological parameters before coronary angioplasty on subsequent restenosis.
abstract: OBJECTIVE
  Restenosis is the major limitation of coronary interventions occurring in nearly a third of the patients undergoing percutaneous transluminal coronary angioplasty (PTCA) with no single, definite predictor demonstrated in an individual patient. Platelets are known to play an important role in the pathogenesis of subsequent restenosis.
  
  
  RESULTS
  In a prospective study, follow-up coronary angiographies were performed in 102 consecutive patients with stable angina who underwent a successful PTCA for single-vessel coronary artery disease. Demographics, baseline lipid profiles (total cholesterol, HDL- and LDL-cholesterol, triglycerides) and haematological parameters (red cell, white cell and platelet counts, haemoglobin concentration, haematocrite %, mean platelet volume, platelet mass and fibrinogen levels) were compared between patients with and without restenosis. In the restenosis group, mean platelet volume (8.82 +/- 0.78 fl vs. 8.13 +/- 0.64 fl, p < 0.001), white cell count (8673 +/- 322 x 10(3)/microl vs. 7513 +/- 232 x 10(3)/microl, p < 0.01) and fibrinogen level (4.2 +/- 1.4 g/l vs 3.6 +/- 1.1 g/l) were significantly higher. The relative odds for developing angiographically defined restenosis were 2.49 times greater in diabetics (p = 0.11) and 2.54 times greater in men (p = 0.13). It is 1.43 times greater in patients with higher fibrinogen levels (p = 0.16). But, the relative odds for developing restenosis were 10.43 times greater in patients with larger pre-procedural mean platelet volumes (p < 0.01).
  
  
  CONCLUSIONS
  There was a positive correlation between mean platelets volume and loss in luminal diameter between post-angioplasty and follow-up angiographies (r = +2.345, p = 0.01). There was no association between restenosis and haemoglobin, haematocrit, red cell count, white cell count, platelet count, platelet mass and plasma fibrinogen level. The development of restenosis after successful coronary angioplasty may be mainly influenced by the platelet size.
authors.affiliation: Turkiye Yuksek Ihtisas Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Avci
authors.forename: Ayca
authors.initials: A
authors.lastname: Boyaci
authors.forename: Kerim
authors.initials: K
authors.lastname: Cağli
authors.forename: Ayhan
authors.initials: A
authors.lastname: Cosgun
authors.forename: Veli
authors.initials: V
authors.lastname: Gokce
authors.forename: Erdal
authors.initials: E
authors.lastname: Duru
authors.forename: Sule
authors.initials: S
authors.lastname: Korkmaz
mesh_terms: D000787:Angina Pectoris / Q000209:etiology; D015906:Angioplasty, Balloon, Coronary; D001792:Blood Platelets / Q000502:physiology*; D002908:Chronic Disease; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D023903:Coronary Restenosis / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D018570:Risk Assessment