title: [A surgical approach to Holmes' tremor associated with high-frequency synchronous bursts].
abstract: BACKGROUND
  The effectiveness of thalamic stimulation is now clearly demonstrated for essential tremor, but remains to be demonstrated for other types of tremor.
  
  
  METHODS
  A young woman presented Holmes' tremor resulting from a pontine tegmental hemorrhage related to an arteriovenous malformation. A surgical approach was considered when major functional impairment persisted at 2-year follow-up despite drug therapy. The patient underwent unilateral thalamic deep brain stimulation (Vim); major improvement persisted at eighteen months follow-up.
  
  
  CONCLUSIONS
  This observation is in line with previous reports suggesting that thalamic surgery can be one of the best options for treating medically intractable Holmes' tremor. The mechanism underlying the tremor, implying dentate-rubro-thalamic pathways is discussed. Moreover, the patient exhibited short periods of 16Hz tremor when her arms were maintained outstretched. Thalamic stimulation also appears to be effective for these high-frequency synchronous cerebellar bursts.
authors.affiliation: Service de Neurologie, ISPPC, Charleroi, Belgique. thierry.piette@chu-charleroi.be
authors.forename: T
authors.initials: T
authors.lastname: Piette
authors.forename: P
authors.initials: P
authors.lastname: Mescola
authors.forename: M
authors.initials: M
authors.lastname: Henriet
authors.forename: C
authors.initials: C
authors.lastname: Cornil
authors.forename: J
authors.initials: J
authors.lastname: Jacquy
authors.forename: B
authors.initials: B
authors.lastname: Vanderkelen
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology / Q000601:surgery*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000473:pathology; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications; D019635:Neurosurgical Procedures / Q000379:methods; D045042:Pedunculopontine Tegmental Nucleus / Q000473:pathology; D010507:Periodicity; D013788:Thalamus / Q000502:physiology / Q000601:surgery; D014202:Tremor / Q000145:classification* / Q000209:etiology / Q000601:surgery*