title: Extramedullary relapse confirmed by fluorescence in situ hybridization study of an ear mass in acute promyelocytic leukemia.
abstract: A 40-year-old man with acute promyelocytic leukemia (APL) achieved complete remission after induction chemotherapy combined with all-trans-retinoic acid. A mass developed in the left ear 24 months later. Relapse of APL was suspected at morphologic examination of the biopsy specimen of the ear mass, but t(15;17) and PML/RAR alpha rearrangement were not detected by chromosomal, fluorescence in situ hybridization (FISH), or reverse transcription polymerase chain reaction analysis of bone marrow samples. FISH performed on the ear mass revealed t(15;17). To our knowledge, this case is the first reported case of extramedullary relapse of APL confirmed by FISH study of a biopsy specimen of extramedullary tissue.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Keun-Wook
authors.initials: KW
authors.lastname: Lee
authors.forename: Jongyoun
authors.initials: J
authors.lastname: Yi
authors.forename: Tak
authors.initials: T
authors.lastname: Yun
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Kim
authors.forename: Dong Soon
authors.initials: DS
authors.lastname: Lee
authors.forename: Sung Sup
authors.initials: SS
authors.lastname: Park
authors.forename: Han Ik
authors.initials: HI
authors.lastname: Cho
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Yoon
authors.forename: Seonyang
authors.initials: S
authors.lastname: Park
authors.forename: Byoung Kook
authors.initials: BK
authors.lastname: Kim
authors.forename: Noe Kyeong
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000328:Adult; D001706:Biopsy; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15; D004428:Ear Neoplasms / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction