Influence of beta-adrenoceptor agonists and antagonists on baclofen-induced memory impairment in mice.
Post-training administration of different doses of baclofen (a GABAB agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta 1-agonist) or salbutamol (a beta 2-agonist) reversed the memory impairment induced by baclofen without exhibiting intrinsic actions on memory when administered alone. The administration of atenolol (a beta 1-antagonist) or propranolol (a beta-antagonist) produced a memory impairment. When co-administered with baclofen, both atenolol and propranolol exacerbated the memory impairment induced by the GABAB agonist. It is concluded that beta-adrenergic mechanisms may be involved in the modulation of memory via GABAB receptors.
Zarrindast
M R
MR
Department of Pharmacology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; National Centre for Drug Addiction Studies, Tehran, Iran. zarinmr@ams.ac.ir
Haidari
H
H
Jafari
M R
MR
Djahanguiri
B
B
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D021461:Animals, Outbred Strains; D001262:Atenolol / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D004280:Dobutamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D018755:GABA Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D007274:Injections, Intraperitoneal; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D011433:Propranolol / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D018755:GABA Agonists; D004280:Dobutamine; D001262:Atenolol; D011433:Propranolol; D001418:Baclofen; D000420:Albuterol