The relationship between aberrant methylation and survival in non-small-cell lung cancers.
The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARbeta and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.
Toyooka
S
S
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Suzuki
M
M
Maruyama
R
R
Toyooka
K O
KO
Tsukuda
K
K
Fukuyama
Y
Y
Iizasa
T
T
Aoe
M
M
Date
H
H
Fujisawa
T
T
Shimizu
N
N
Gazdar
A F
AF
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology*; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D019942:Genes, p16; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
D004273:DNA, Neoplasm