Novel poly(ethylene glycol) embedded polyamidoamine side chain dendritic polyurethane architecture: synthesis and preliminary studies on the cytotoxicity and interaction with tryptophan molecule.
Novel polyamidoamine (PAMAM) side chain dendritic polyurethane (SCDPU-PEG) architecture embedded with poly(ethylene glycol) has been prepared. This novel SCDPU-PEG was characterized by means of FT-IR, NMR ((1)H and (13)C) spectroscopic, GPC, and thermal analyses and intrinsic viscosity measurements. Studies on cytotoxicity by means of MTT assay and interaction of L-tryptophan with this polydendron have been achieved.
Ghosh
Samaresh
S
Materials Science Centre, Indian Institute of Technology, Kharagpur - 721302, India. gsamaresh@hotmail.com
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002460:Cell Line; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008422:Materials Testing; D051379:Mice; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014364:Tryptophan / Q000737:chemistry*
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D011073:Polyamines; D011140:Polyurethanes; D011092:Polyethylene Glycols; D014364:Tryptophan