title: Optical projection tomography.
abstract: Optical projection tomography is a new approach for three-dimensional (3-D) imaging of small biological specimens. It fills an imaging gap between MRI and confocal microscopy, being most suited to specimens that are from 1 to 10 mm across. The tomographic principles of optical projection tomography (OPT) are explained, its most important applications in biomedical research explored, and comparisons drawn of its pros and cons compared to a number of alternative imaging technologies.
authors.affiliation: MRC Human Genetics Unit, Western General Hospital, Crewe Road South, EH4 2XU, United Kingdom. James.Sharpe@hgu.mrc.ac.uk
authors.forename: James
authors.initials: J
authors.lastname: Sharpe
mesh_terms: D000818:Animals; D015870:Gene Expression; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018613:Microscopy, Confocal; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*