Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats.
Since a very complicated technique is necessary to measure cerebral blood flow (CBF) with [14C]iodoantipyrine in small animals, a practical and easy method is needed. In this paper, the differential uptake ratio (DUR) at 5 min after injection of N-isopropyl-p-[125I]iodoamphetamine (IMP) was estimated as an index of CBF in normal rats and compared with the quantitative CBF value measured using [15O]H2O and dynamic PET scan. A good correlation between the two values was obtained. The results indicate that DUR of [125I]IMP at 5 min after injection in rats is a useful and practical indicator of CBF since neither arterial blood sampling nor metabolite correction is necessary.
Temma
Takashi
T
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Magata
Yasuhiro
Y
Mukai
Takahiro
T
Kitano
Haruhiro
H
Konishi
Junji
J
Saji
Hideo
H
D000465:Algorithms; D000818:Animals; D001345:Autoradiography; D001834:Body Water; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D020367:Iofetamine; D008297:Male; D008863:Microspheres; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D051381:Rats; D017208:Rats, Wistar
D019275:Radiopharmaceuticals; D020367:Iofetamine