Evidence for endocrine disruption in invertebrates.
The issue of endocrine disruption (ED) in invertebrates has generated remarkably little interest in the past compared to research with aquatic vertebrates in this area. However, with more than 95% of all known species in the animal kingdom, invertebrates constitute a very important part of the global biodiversity with key species for the structure and function of aquatic and terrestrial ecosystems. Despite the fact that ED in invertebrates has been investigated on a smaller scale than in vertebrates, invertebrates provide some of the best documented examples for deleterious effects in wildlife populations following an exposure to endocrine-active substances. The article provides an overview of the diversity in endocrine systems of invertebrates. The principal susceptibility of invertebrates to endocrine-active compounds is demonstrated with the case studies of tributyltin effects in mollusks and of insect growth regulators, the latter as purposely synthesized endocrine disrupters. The additional evidence for ED in invertebrates from laboratory and field studies is summarized as an update and amendment of the EDIETA report from 1998. Finally, conclusions about the scale and implications of the observed effects are drawn and research needs are defined.
Oetken
Matthias
M
Department of Ecology and Evolution-Ecotoxicology, Johann Wolfgang Goethe University Frankfurt, D-60054 Frankfurt am Main, Germany.
Bachmann
Jean
J
Schulte-Oehlmann
Ulrike
U
Oehlmann
Jörg
J
D000818:Animals; D004703:Endocrine System / Q000502:physiology; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects / Q000378:metabolism; D006126:Group Processes; D007447:Invertebrate Hormones / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D007448:Invertebrates / Q000033:anatomy & histology / Q000502:physiology*; D008386:Marine Biology; D012098:Reproduction / Q000502:physiology; D012733:Sex Differentiation / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014220:Trialkyltin Compounds / Q000009:adverse effects / Q000378:metabolism
D004785:Environmental Pollutants; D007447:Invertebrate Hormones; D014220:Trialkyltin Compounds; C011559:tributyltin