Endothelial changes associated with topical dorzolamide do appear to be significant.
Epstein
Randy J
RJ
Brown
Steven V L
SV
Konowal
Alexandra
A
D000287:Administration, Topical; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced*; D004728:Endothelium, Corneal / Q000187:drug effects*; D006801:Humans; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D013876:Thiophenes / Q000008:administration & dosage / Q000009:adverse effects*
D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide