title: Epithelium-mesenchyme: a balancing act of RhoGAP and RhoGEF.
abstract: Transitions between epithelium and mesenchyme, in either direction, contribute repeatedly to animal development. Three striking papers suggest that distinct components with opposite activities, which together form a complex known for its role in cytokinesis, control these opposite transitions.
authors.affiliation: IGBMC, 1 rue Laurent Fries, BP10142, 67404 Illkirch, France. lmichel@igbmc.u-strasbg.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Labouesse
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D004330:Drosophila / Q000196:embryology* / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D004848:Epithelium / Q000196:embryology; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D016547:Kinesins / Q000378:metabolism; D008648:Mesoderm / Q000166:cytology; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D064067:Rho Guanine Nucleotide Exchange Factors; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; C121865:Pbl protein, Drosophila; D064067:Rho Guanine Nucleotide Exchange Factors; C114455:ZEN-4 protein, C elegans; C085379:rho GTPase-activating protein; D016547:Kinesins; D020741:rho GTP-Binding Proteins