title: Cytoplasmic dysmorphisms in metaphase II chimpanzee oocytes.
abstract: Prior to fertilization by intracytoplasmic sperm injection (ICSI), cytoplasmic organization was evaluated in metaphase II chimpanzee oocytes obtained from stimulated ovaries. The findings demonstrate a high frequency of anomalies that are remarkably similar to the types of cytoplasmic dysmorphisms reported for human oocytes used in IVF. Similar to the human, the occurrence of these anomalies was oocyte- and animal-specific and associated with reduced competence as indicated by embryo development in vitro to the blastocyst stage.
authors.affiliation: Kumamoto Primates Research Park, Sanwa Kagaku Kenkyusho Co., Ltd, 990 Nishikuroiwa, Ohtao, Misumi-Cho, Uto-Gun, Kumamoto 869-3201, Japan. ki_suzuki@skk-net.com
authors.forename: Kimie
authors.initials: K
authors.lastname: Suzuki
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Yoshimoto
authors.forename: Kohji
authors.initials: K
authors.lastname: Shimoda
authors.forename: Wataru
authors.initials: W
authors.lastname: Sakamoto
authors.forename: Yukie
authors.initials: Y
authors.lastname: Ide
authors.forename: Takehito
authors.initials: T
authors.lastname: Kaneko
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Nakashima
authors.forename: Ikuo
authors.initials: I
authors.lastname: Hayasaka
authors.forename: Naomi
authors.initials: N
authors.lastname: Nakagata
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000502:physiology; D003593:Cytoplasm / Q000235:genetics / Q000473:pathology*; D047108:Embryonic Development; D005260:Female; D008677:Metaphase; D009865:Oocytes / Q000473:pathology* / Q000502:physiology; D002679:Pan troglodytes; D020554:Sperm Injections, Intracytoplasmic