title: An investigation on the influence of a vinyl pyrrolidone/vinyl acetate copolymer on the moisture permeation, mechanical and adhesive properties of aqueous-based hydroxypropyl methylcellulose film coatings.
abstract: Polymers for aqueous film coating, such as hydroxypropyl methylcellulose (HPMC), often require the inclusion of a plasticizer to reduce brittleness and increase flexibility and ductility. A vinyl pyrrolidone/vinyl acetate copolymer (S630) was investigated for its influence on HPMC film coating parameters, comparing the results with a commonly used plasticizer, polyethylene glycol and another copolymer, polyvinyl alcohol. The viscous properties of the solutions and the glass transition temperatures of the equivalent polymer films were evaluated. Its effect on the film properties, such as appearance, surface roughness, moisture permeation and mechanical properties, as well as its ability to promote better adhesion of the film coat to the core surface, was compared. S630 was able to reduce the viscosity of the polymer solution and glass transition temperature of HPMC, as well as, enhance the mechanical properties of the cast film. The moisture permeation was slightly reduced but not to the same extent as polyethylene glycol. A 10% concentration of S630 increased the adhesive strength and toughness of the HPMC film coat. In conclusion, S630 was effective as a film-former, substrate adhesive and plasticizer. It has the potential to be used to replace the more volatile plasticizers which have problems of loss or migration.
authors.affiliation: Department of Pharmacy, National University of Singapore.
authors.forename: Teresa Swee Har
authors.initials: TS
authors.lastname: Kwok
authors.forename: Bruce Vivian
authors.initials: BV
authors.lastname: Sunderland
authors.forename: Paul Wan Sia
authors.initials: PW
authors.lastname: Heng
mesh_terms: D000269:Adhesives / Q000737:chemistry*; D006813:Humidity; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D010539:Permeability; D011760:Pyrrolidinones / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000269:Adhesives; D011760:Pyrrolidinones; D014753:Vinyl Compounds; D065347:Hypromellose Derivatives; D008747:Methylcellulose; C011566:vinyl acetate