title: Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa.
abstract: Various studies have evaluated the possible role of the -1438G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P = 0.003 and P = 0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P = 0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies.
authors.affiliation: Department of Neurological and Psychiatric Sciences, Psychiatry Unit, University of Florence, Viale Morgagni, 85, 50134, Italy. valdo.ricca@unifi.it
authors.forename: Valdo
authors.initials: V
authors.lastname: Ricca
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
authors.forename: Maura
authors.initials: M
authors.lastname: Boldrini
authors.forename: Elena
authors.initials: E
authors.lastname: Cellini
authors.forename: Milena
authors.initials: M
authors.lastname: di Bernardo
authors.forename: Claudia
authors.initials: C
authors.lastname: Ravaldi
authors.forename: Andrea
authors.initials: A
authors.lastname: Tedde
authors.forename: Silvia
authors.initials: S
authors.lastname: Bagnoli
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Placidi
authors.forename: Carlo Maria
authors.initials: CM
authors.lastname: Rotella
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology*; D002032:Bulimia / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A