Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco.
This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.
Hernández
Juan C
JC
Instituto de Productos Naturales y Agrobiología-CSIC, Instituto Universitario de Bio-Orgánica Antonio González, La Laguna, Tenerife, Spain.
León
Francisco
F
Quintana
José
J
Estévez
Francisco
F
Bermejo
Jaime
J
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D017209:Apoptosis; D031409:Dracaena / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity*; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*
D000972:Antineoplastic Agents, Phytogenic; C496798:Icogenin; D012503:Saponins; D013256:Steroids; D011065:Poly(ADP-ribose) Polymerases