CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice.
DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.
Lin
Xiaoqi
X
Department of Neurology, University of Chicago, IL 60637, USA.
Ma
Xiaoxing
X
Rodriguez
Moses
M
Roos
Raymond P
RP
D019264:Adoptive Transfer; D000818:Animals; D001921:Brain / Q000821:virology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D051379:Mice; D017945:Theilovirus / Q000276:immunology*