title: Predicting the recurrence/metastasis of stage II and III breast cancer with lymph node metastasis.
abstract: This study compared prediction of the recurrence of breast cancer by detection of occult neoplastic cells (ONCs) in lymph nodes or by using the criteria for a high risk of recurrence and metastasis of gastric/large bowel cancer. The subjects were 45 patients with stage II and III node-positive breast cancer. Prediction of recurrence by detection of ONCs showed a sensitivity of 78.6% (11/14), a false-negative rate of 21.4% (3/14), a specificity of 96.4% (30/31), a false-positive rate of 3.2% (1/31), and an accuracy of 87.7% in patients with stage II and III node-positive cancer. Prediction of recurrence based on positivity for at least 2 of the high-risk criteria showed a sensitivity of 92.9% (13/14), a false-negative rate of 7.1% (1/14), a specificity of 87.1% (27/31), a false-positive rate of 12.9% (4/31), and an accuracy of 90.0% in patients with stage II and III node-positive cancer. These results suggest that ONCs plus the high-risk criteria are useful for predicting recurrence/metastasis of stage II and III node-positive breast cancer during the early postoperative period with a high sensitivity and accuracy.
authors.affiliation: Department of Surgery, Tokai University Oiso Hospital, Oiso, Kanagawa 259-0198, Japan. onc-res@oiso.u-tokai.ac.jp
authors.forename: Masaya
authors.initials: M
authors.lastname: Mukai
authors.forename: Shinkichi
authors.initials: S
authors.lastname: Sato
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kimura
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Komatsu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ninomiya
authors.forename: Hisao
authors.initials: H
authors.lastname: Nakasaki
authors.forename: Kyouji
authors.initials: K
authors.lastname: Ogoshi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000096:biosynthesis; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D012008:Recurrence; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D007633:Keratins