Kinetic logic: a tool for describing the dynamics of infectious disease behavior.
Most of the infectious diseases imply biological regulations controlled by several feedback loops or circuits. Kinetic logic, which is a method easily accessible to biologists or physicians, and which takes time and thresholds of activity into account, seems a convenient method for building simplified models related to this field. This implies usually qualitative predictions concerning the dynamics of such biological systems, leading to a movement back and forth between experimentation or observation and logical description. Here, we illustrate this simple modelling method in building elementary models concerning prion infection to demonstrate how to proceed. We also discuss and summarize how this method has been used for studying several viral diseases. As an example, we show how predictions related to the rhabdovirus cycle, were experimentally verified.
Martinet-Edelist
Claire
C
Virologie moléculaire et structurale, CNRS, 91198 Gif/Yvette-Cedex, France. edelist@vms.cnrs-gif.fr
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D007239:Infections / Q000503:physiopathology* / Q000821:virology; D007700:Kinetics; D008128:Logic; D008954:Models, Biological; D017096:Prion Diseases / Q000503:physiopathology*; D011328:Prions / Q000502:physiology; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D012209:Rhabdoviridae / Q000235:genetics / Q000502:physiology
D011328:Prions; D012367:RNA, Viral