title: Seasonal variation of kaurenoic acid, a hypoglycemic diterpene present in Wedelia paludosa (Acmela brasiliensis) (Asteraceae).
abstract: We evaluated the variation of the concentration of kaurenoic acid (1), which is a bioactive diterpene, in leaves, flowers, stems and roots from Wedelia paludosa (Acmela brasiliensis) for different seasons using the HRGC/FID method. The results indicated that the concentration of 1 is higher in the roots and stems during the autumn. The pharmacological results suggested that kaurenoic acid is responsible, at least in part, for the hypoglycemic potential detected in this plant.
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina (UFSC), 88040-900, Florianópolis, SC, Brazil.
authors.forename: Louisiane Faccio V
authors.initials: LF
authors.lastname: Bresciani
authors.forename: Rosendo Augusto
authors.initials: RA
authors.lastname: Yunes
authors.forename: Cristiani
authors.initials: C
authors.lastname: Bürger
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: De Oliveira
authors.forename: Kauê Leal
authors.initials: KL
authors.lastname: Bóf
authors.forename: Valdir
authors.initials: V
authors.lastname: Cechinel-Filho
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D004224:Diterpenes / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D006943:Hyperglycemia / Q000097:blood; D007004:Hypoglycemic Agents / Q000032:analysis* / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D012621:Seasons; D031209:Wedelia / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D004224:Diterpenes; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C051436:kaurenoic acid; D005905:Glyburide