Traumatic calcinosis cutis in a dialysis patient.
A patient with end-stage renal disease and refractory hyperparathyroidism was evaluated for acute-onset thickening and hardening of the skin of the lower extremities. Her clinical course and physical examination findings were consistent with the recently described entity of nephrogenic fibrosing dermopathy. However, skin biopsy results showed metastatic and dystrophic calcification, without calcific uremic arteriolopathy (calciphylaxis). The patient reported a history of self-inflicted trauma; the authors postulate that trauma, in the setting of hyperparathyroidism and an elevated serum calcium phosphorous product, resulted in the subcutaneous deposition of calcium salts. To the authors' knowledge, this is the first report of metastatic and dystrophic calcification, without calciphylaxis, in a patient with refractory hyperparathyroidism. This case underscores both the rich variety of skin conditions seen in patients undergoing dialysis and recent developments in the field of dermatologic disorders associated with end-stage renal disease.
Taylor
Eric N
EN
Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. entaylor@partners.org
Henderson
Joel M
JM
Rennke
Helmut G
HG
Magee
Colm C
CC
D002114:Calcinosis / Q000209:etiology*; D005218:Fat Necrosis / Q000209:etiology; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D010530:Peritoneal Dialysis; D016728:Self-Injurious Behavior; D012871:Skin Diseases / Q000209:etiology*; D013848:Thigh / Q000293:injuries