Linking tumor suppression, DNA damage and the anaphase-promoting complex.
A recent study shows that the RASSF1A tumor suppressor functions as a regulator of the ordered proteolytic steps that organize mitosis. By controlling the stability of microtubules and the activity of the anaphase-promoting complex (APC), RASSF1A might provide a crucial link between mechanisms of tumor suppression and mitotic cell division. Furthermore, another recent study shows that protein kinase A, which is a key growth regulator, inhibits the APC during mitosis in yeast.
Jackson
Peter K
PK
Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, CA 94305, USA. pjackson@stanford.edu
D064173:Anaphase-Promoting Complex-Cyclosome; D017868:Cyclic AMP-Dependent Protein Kinases / Q000494:pharmacology; D004249:DNA Damage / Q000502:physiology*; D006801:Humans; D008938:Mitosis / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015003:Yeasts / Q000201:enzymology
C411762:RASSF1 protein, human; D025521:Tumor Suppressor Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D017868:Cyclic AMP-Dependent Protein Kinases