Association between maternal exposure to elevated ambient sulfur dioxide during pregnancy and term low birth weight.
This retrospective cohort study investigated whether the risk of delivering full term (37-44 completed weeks of gestation) low birth weight (LBW) infants is associated with differences in exposure to air pollutants in different trimesters. Full-term infants (37 completed weeks of gestation) with a birth weight below 2500 g were classified as term LBW infants. The study infants comprised 92,288 full-term live singletons identified from the Taiwan birth registry and born in the city of Taipei or Kaoshiung in Taiwan between 1995 and 1997. Maternal exposures to various air pollutants including CO, SO2, O3, NO2, and PM10 in each trimester of pregnancy was estimated as the arithmetic means of all daily measurements taken by the air quality monitoring station nearest to the district of residence of the mother at birth. The multivariable logistic regression model with adjustment for potential confounders was used to assess the independent effect of specific air pollutants on the risk of term LBW. This study suggested a 26% increase in term LBW risk given maternal ambient exposure to SO2 concentration exceeding 11.4 ppb during pregnancy compared to low exposure (<7.1 ppb) (OR=1.26, 95% CI=1.04-1.53). Since the relative risk of term LBW was reassessed according to exposure level in each trimester, mothers exposed to >12.4 ppb of SO2 in the last trimester showed 20% higher risk (OR=1.20, 95% CI=1.01-1.41) of term LBW delivery than mothers with lower exposure (<6.8 ppb). No significant elevation ORs was observed for other air pollutants.
Lin
Chih-Ming
CM
Department of Public Health, College of Medicine, Fu Jen Catholic University, Taipei Hsien, Taiwan, ROC.
Li
Chung-Yi
CY
Yang
Guang-Yang
GY
Mao
I-Fang
IF
D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D008499:Medical Records; D011247:Pregnancy; D011264:Pregnancy Trimesters; D012189:Retrospective Studies; D012621:Seasons; D013458:Sulfur Dioxide / Q000009:adverse effects*; D013624:Taiwan / Q000453:epidemiology
D000393:Air Pollutants; D013458:Sulfur Dioxide