Abnormal cortical voice processing in autism.
Impairments in social interaction are a key feature of autism and are associated with atypical social information processing. Here we report functional magnetic resonance imaging (fMRI) results showing that individuals with autism failed to activate superior temporal sulcus (STS) voice-selective regions in response to vocal sounds, whereas they showed a normal activation pattern in response to nonvocal sounds. These findings suggest abnormal cortical processing of socially relevant auditory information in autism.
Gervais
Hélène
H
ERM 0205, INSERM-CEA, DRM, DSV, Service Hospitalier Frédéric Joliot, 4, place du General Leclerc, 91406, Orsay, France.
Belin
Pascal
P
Boddaert
Nathalie
N
Leboyer
Marion
M
Coez
Arnaud
A
Sfaello
Ignacio
I
Barthélémy
Catherine
C
Brunelle
Francis
F
Samson
Yves
Y
Zilbovicius
Mônica
M
D000328:Adult; D001303:Auditory Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001307:Auditory Perception / Q000502:physiology*; D001321:Autistic Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography