Glycogenin: the primer for mammalian and yeast glycogen synthesis.
Glycogen synthesis, whether in mammalian tissue, yeast, or Agrobacterium tumefaciens or other bacteria, is initiated by autoglucosylation of a protein. Initiation in muscle, by a self-glucosylating protein, glycogenin-1, is the most thoroughly studied system, as is described here. These relatively recent findings have prompted a rekindling of interest in the intermediates lying between the primer and mature mammalian glycogen.
Lomako
Joseph
J
Department of Biochemistry and Molecular Biology, University of Miami School Medicine, Miami, FL 33136, USA.
Lomako
Wieslawa M
WM
Whelan
William J
WJ
D015061:1,4-alpha-Glucan Branching Enzyme / Q000378:metabolism; D016960:Agrobacterium tumefaciens; D000818:Animals; D001665:Binding Sites; D005947:Glucose; D005964:Glucosyltransferases / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis* / Q000737:chemistry; D006006:Glycogen Synthase / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism / Q000502:physiology*; D015003:Yeasts
D006023:Glycoproteins; D009124:Muscle Proteins; C051887:glycogenin; D006003:Glycogen; D005964:Glucosyltransferases; D006006:Glycogen Synthase; D015061:1,4-alpha-Glucan Branching Enzyme; D005947:Glucose