A trio family study showing association of the lymphotoxin-alpha N26 (804A) allele with coronary artery disease.
Family-based studies to map susceptibility genes through linkage disequilibrium have been successful in early-onset diseases where parental-proband trios are readily collected, but are believed to be unworkable for late-onset diseases such as coronary artery disease (CAD). PROCARDIS is a European multicentre study that was designed to identify susceptibility genes for CAD. We have tested the transmission of a putatively functional allele, lymphotoxin-alpha N26 (804A), in more than 400 PROCARDIS trio families. The present study demonstrates association of this allele with CAD in white Europeans, a different ethnic group with a heavier CAD burden than the Japanese in which the association was initially identified, which suggests a broad relevance to CAD susceptibility. The practicalities of implementing a trio-family design for late-onset diseases are discussed.
D000483:Alleles; D003324:Coronary Artery Disease / Q000235:genetics*; D017931:DNA Primers; D005190:Family; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008233:Lymphotoxin-alpha / Q000235:genetics*; D013058:Mass Spectrometry; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012107:Research Design; D044465:White People
D017931:DNA Primers; D008233:Lymphotoxin-alpha