title: [Epidemiological study of nasopharyngeal carcinoma risk in relatives of high-risk families in Guangdong].
abstract: OBJECTIVE
  Familial clustering of NPC has been widely observed, however, related investigations were mainly involved in individual reports for high-risk families or case-control study with small sample size, so no quantitive evaluation for NPC risk in relatives of high-risk families documented in high-risk area until now. The purpose of the study was to estimate NPC risk among relatives of high-risk pedigrees in Guangong province, so as to provide information for genetic epidemiology and clinical genetic consultation.
  
  
  METHODS
  One hundred and thirteen high-risk pedigrees were collected in the Cancer Center of Sun Yat-sen University, and standardized incidence ratio (SIR) was used to estimate NPC risk of first degree relatives (FDR).
  
  
  RESULTS
  NPC risk was significantly higher in first degree relatives that in general population, and SIR was 37.55; in addition, SIRs were 50.72, 79.64, 7.12, and 33.58 in their brothers, sisters, fathers, and mothers respectively.
  
  
  CONCLUSIONS
  NPC risk of relatives in familial NPC pedigrees elevates 7.12 to 79.64 times in high-risk families.
authors.affiliation: Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jia
authors.forename: Zong-Li
authors.initials: ZL
authors.lastname: Xu
authors.forename: Bing-Jian
authors.initials: BJ
authors.lastname: Feng
authors.forename: Li-Xi
authors.initials: LX
authors.lastname: Huang
authors.forename: Xing-Juan
authors.initials: XJ
authors.lastname: Yu
authors.forename: Qi-Sheng
authors.initials: QS
authors.lastname: Feng
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Zeng
mesh_terms: D002681:China / Q000453:epidemiology; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors