title: Asymptomatic sensitisation to grapes in a sample of workers in the wine industry.
abstract: OBJECTIVE
  To assess the prevalence of sensitisation to grapes (Vitis vinifera var. agiorghitiko) in a population with repeated exposure to grape allergens through direct cutaneous contact as well as through the gastrointestinal tract.
  
  
  METHODS
  One hundred and twenty subjects were enrolled in each of four groups: grape harvesters, winery workers in selection of grapes, winery workers operating de-stemming/crushing/pressing machines, and administrative personnel. Sensitisation to grapes was examined by skin prick-to-prick tests with fresh fruit and juice.
  
  
  RESULTS
  Eight harvesters and five workers in grape selection had positive reaction to the grapes tested. No machine operators or administrative personnel had positive tests. The likelihood of sensitisation was estimated at 3.7% per year of occupation by logistic regression analysis. None of the employees reported symptoms associated with sensitisation to grapes.
  
  
  CONCLUSIONS
  Asymptomatic sensitisation to grapes was detected only in workers handling the fruit, suggesting that sensitisation is more likely to occur through cutaneous exposure and/or minor wounding than through the gastrointestinal tract. Prevalence rates were high and the clinical impact needs to be further investigated.
authors.affiliation: Department of Allergy, University of Athens, Andreas Sygros Hospital, Athens, Greece. stamgreg@yahoo.gr
authors.forename: D
authors.initials: D
authors.lastname: Kalogeromitros
authors.forename: D
authors.initials: D
authors.lastname: Rigopoulos
authors.forename: S
authors.initials: S
authors.lastname: Gregoriou
authors.forename: V
authors.initials: V
authors.lastname: Mousatou
authors.forename: N
authors.initials: N
authors.lastname: Lyris
authors.forename: D
authors.initials: D
authors.lastname: Papaioannou
authors.forename: A
authors.initials: A
authors.lastname: Katsarou-Katsari
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D019649:Food Industry; D005638:Fruit / Q000276:immunology; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D012044:Regression Analysis; D012882:Skin Tests / Q000379:methods; D027843:Vitis / Q000276:immunology*; D014920:Wine
chemical_list: D000485:Allergens