Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity.
A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.
Cocco
Maria T
MT
Dipartimento di Tossicologia, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy. tcocco@unica.it
Congiu
Cenzo
C
Onnis
Valentina
V
Morelli
Micaela
M
Felipo
Vicente
V
Cauli
Omar
O
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008297:Male; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects*; D011725:Pyridines / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D000700:Analgesics; D002264:Carboxylic Acids; D009539:Nicotinic Acids; D011725:Pyridines; C407065:trifluoromethylpyridine