title: Successful treatment of progressive stage 4s hepatic neuroblastoma in a neonate with intra-arterial chemoembolization.
abstract: Stage 4s neuroblastoma (NB) is a unique entity seen in infants less than 1 year of age, with metastatic disease confined to liver, skin, or bone marrow. Despite metastatic spread, stage 4s NB has a favorable outcome. An exception to this is seen in neonates who present with progressive enlargement of the liver with secondary respiratory compromise and liver failure. We describe a 4-week-old neonate who presented with 4s NB, with a rapidly enlarging liver, resulting in respiratory and hepatic failure, who had a rapid, sustained, and ongoing response to chemoembolization of the hepatic artery. This approach is feasible at this age, and may be effective in improving the outcome in this group of patients.
authors.affiliation: Department of Pediatric Hematology-Oncology, Hadassah University Hospital, Jerusalem, Israel. michaelw@hadassah.org.il
authors.forename: Michael
authors.initials: M
authors.lastname: Weintraub
authors.forename: Allan I
authors.initials: AI
authors.lastname: Bloom
authors.forename: Eitan
authors.initials: E
authors.lastname: Gross
authors.forename: Shoshana
authors.initials: S
authors.lastname: Revel-Vilk
authors.forename: Sarit
authors.initials: S
authors.lastname: Shahroor
authors.forename: Benjamin Z
authors.initials: BZ
authors.lastname: Koplewitz
authors.forename: Arnold I
authors.initials: AI
authors.lastname: Freeman
mesh_terms: D016461:Chemoembolization, Therapeutic / Q000379:methods*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D009447:Neuroblastoma / Q000473:pathology / Q000628:therapy*