title: Virus induced chromosomal abnormalities in Chinese hamster lung cell line and human peripheral blood leukocyte culture.
abstract: Chinese hamster lung (CHL) cells were susceptible to Herpes Simplex type-1 and Chandipura viruses; which induced chromosomal abnormalities in these cells. Chromosomal changes induced in these cells were specific. The cells were refractory to measles virus and chromosomal abnormalities were not detected after inoculation of the virus. On the other hand human peripheral blood (HPB) leukocytes were susceptible to all the 3 viruses studied and exhibited chromosomal abnormalities upon infection. The aberrations induced in HPBL cultures were random. The results suggest that a virus could induce chromosomal changes only in susceptible cells. This is the first report of comparative in vitro study on chromosomes.
authors.affiliation: National Institute of Virology, 20-A Dr. Ambedkar Road, Pune 411 001, India.
authors.forename: Smita P
authors.initials: SP
authors.lastname: Paranjape
authors.forename: U V
authors.initials: UV
authors.lastname: Wagh
mesh_terms: D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007621:Karyotyping; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000821:virology*; D008168:Lung / Q000166:cytology / Q000821:virology*; D018116:Vesiculovirus / Q000502:physiology*