Surgical treatment of polycystic ovary syndrome associated with infertility.
Laparoscopic ovarian drilling is a relatively simple procedure performed by minimal access and usually on an outpatient basis. It provides an alternative treatment option for polycystic ovary syndrome (PCOS) patients anovulatory to clomiphene citrate. The mechanism of action of laparoscopic ovarian drilling is unclear; its beneficial effect is apparently due to destruction of the androgen-producing stroma. The procedure appears to have little or no effect on insulin sensitivity and lipoprotein profile. The majority (56-94%) of PCOS patients who are clomiphene citrate resistant ovulate after drilling, and at least half of them go on to achieve a pregnancy. Predictive factors for pregnancy are younger age and lower body mass index. The endocrine changes resulting from ovarian drilling last for an extended period of time. Exogenous gonadotrophin treatment and laparoscopic ovarian drilling appear to yield comparable ovulation and pregnancy rates; however, multiple pregnancy is rare with drilling. There are several complications associated with the procedure, including post-operative periadnexal adhesion formation. Alternative treatment options, including lifestyle modification (diet and exercise) and metformin, may well reduce the need for ovarian drilling in well-selected cases. Progress in understanding of this complex syndrome and effective new treatments will further diminish the need for surgery.
Gomel
Victor
V
Department of Obstetrics and Gynecology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Victorgomel@cs.com
Yarali
Hakan
H
D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D017588:Hyperandrogenism / Q000628:therapy; D007247:Infertility, Female / Q000601:surgery*; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D008687:Metformin / Q000627:therapeutic use; D010053:Ovary / Q000601:surgery; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome
D006062:Gonadotropins; D002996:Clomiphene; D008687:Metformin