title: No significant change of plasma beta-endorphin levels of psoriasis patients after synchronous balneophototherapy.
abstract: OBJECTIVE
  Previous studies suggested that beta-endorphin has a pathogenic role in psoriasis: its increased plasma concentration may play a role in the neuroimmunological processes in the pathomechanism of the disease, and plasma beta-endorphin levels should reflect the changes in the patients' skin status. The purpose of this study was to investigate the changes of peripheral blood beta-endorphin levels in psoriatic patients in conjunction with changes in their skin symptoms after synchronous balneophototherapy.
  
  
  METHODS
  With synchronous balneophototherapy, 12 patients with extended skin symptoms of psoriasis were treated. The therapy followed the Regensburg protocol, consisting of a basic course of 35 sessions. Patients' skin status was characterized by evaluating the Psoriasis Area and Severity Index score before and after the therapy course. Blood samples were taken before treatment, and 1 day after the last session, with symptom-free skin. Plasma beta-endorphin levels were measured by a specific radioimmunoassay developed by the authors.
  
  
  RESULTS
  There was no significant change in plasma levels of beta-endorphin after clinical clearance of psoriatic skin symptoms.
  
  
  CONCLUSIONS
  In this non-randomized, uncontrolled study no significant difference could be detected between plasma beta-endorphin levels before and after a basic course of synchronous balneophototherapy in patients with psoriasis. Although beta-endorphin has many neuroimmunological effects, the changes of its plasma level do not consistently reflect the skin status. Inflammation in psoriatic skin lesions is probably not mediated directly by circulating beta-endorphin.
authors.affiliation: Department of Dermatovenerology and Oncodermatology, Semmelweis University, Maria u.41, 1085 Budapest, Hungary. holpet@bor.sote.hu
authors.forename: P
authors.initials: P
authors.lastname: Holló
authors.forename: T
authors.initials: T
authors.lastname: Bender
authors.forename: M
authors.initials: M
authors.lastname: Marschalkó
authors.forename: R
authors.initials: R
authors.lastname: Gonzalez
authors.forename: I
authors.initials: I
authors.lastname: Barna
authors.forename: A
authors.initials: A
authors.lastname: Horváth
mesh_terms: D000328:Adult; D001452:Balneology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010789:Phototherapy; D011565:Psoriasis / Q000628:therapy*; D011863:Radioimmunoassay / Q000379:methods; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin