Calcitonin in the prevention and therapy of osteoporotic syndromes.
It is now generally accepted that estrogen status, exercise and adequate calcium intake are the singularly most important factors which guarantee the assumption of genetically programmed peak bone mass. Physicians also recognize that estrogen replacement therapy is not only essential to prevent bone loss in the early postmenopausal female, but also for the long-term preservation of bone mineral density. The efficacy of either continuous or intermittent calmon calcitonin administration in preventing further bone loss and in some instances decreasing fracture incidences in established osteoporotic syndromes is currently well established. As noted during a variety of controlled investigations performed both in the United States and abroad, and in the Physician's Resource Manual on Osteoporosis published by the United States National Osteoporosis Foundation, salmon calcitonin is also effective in early postmenopausal women who are not candidates for estrogen replacement therapy in addition to those patients with established osteoporosis. The practicing physician should acknowledge that of all the anti-resorptive agents recommended for therapy in osteoporotic syndromes, estrogens and salmon calcitonin are currently the only two drugs recommended by the U.S. Food and Drug Administration (USFDA) as safe and effective as treatment modalities in osteoporosis.
Avioli
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LV
Washington University School of Medicine, St. Louis, MO 63110, USA.