[Development of theophylline in treatment of asthma and chronic obstructive pulmonary disease].
Theophylline has been reduced usage in asthma and chronic obstructive pulmonary disease because of the high frequency of side effects and the relatively low efficacy. However, recent researches have demonstrated that low-dose theophylline can not only relax airway smooth muscle but also have anti-inflammatory or immunomodulatory actions, which provides theory basis for the treatment of asthma and chronic obstructive pulmonary disease.
Xu
Yong-jian
YJ
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. yjxu@tjh.tjmu.edu.cn
D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D013806:Theophylline / Q000009:adverse effects / Q000627:therapeutic use*
D001993:Bronchodilator Agents; D013806:Theophylline