Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c.
OBJECTIVE
To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.


METHODS
A joint analysis of two prospective studies with baseline glycemia measurements.


RESULTS
The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c < or = 6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose > or = 7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L.


CONCLUSIONS
Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c.
Qiao
Qing
Q
Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. qing.qiao@ktl.fi
Dekker
Jacqueline M
JM
de Vegt
Femmie
F
Nijpels
Giel
G
Nissinen
Aulikki
A
Stehouwer
Coen D A
CD
Bouter
Lex M
LM
Heine
Robert J
RJ
Tuomilehto
Jaakko
J
D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis*; D002423:Cause of Death; D003920:Diabetes Mellitus / Q000097:blood / Q000401:mortality*; D005215:Fasting; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies
D001786:Blood Glucose; D006442:Glycated Hemoglobin