Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex.
We developed a highly enantioselective separation system for the optically active compounds, (S)-ibuprofen and l-phenylalanine, from their racemic mixtures by employing a supported liquid membrane (SLM) encapsulating a surfactant-lipase complex (or a surfactant-alpha-chymotrypsin complex). In the present system, enzymes encapsulated in the liquid-membrane phase effectively drove the enantioselective transport of optically active compounds through the SLM. This novel SLM allowed high enantioselectivity (ee over 91%) in the optical resolution of racemic ibuprofen and phenylalanine.
Miyako
Eijiro
E
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, PRESTO, JST, Fukuoka 812-8581, Japan.
Maruyama
Tatsuo
T
Kamiya
Noriho
N
Goto
Masahiro
M
D002384:Catalysis; D002918:Chymotrypsin / Q000737:chemistry; D004798:Enzymes / Q000737:chemistry*; D004800:Enzymes, Immobilized / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry; D008049:Lipase / Q000737:chemistry; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D010649:Phenylalanine / Q000737:chemistry; D013237:Stereoisomerism; D013501:Surface-Active Agents / Q000737:chemistry*
D004798:Enzymes; D004800:Enzymes, Immobilized; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D013501:Surface-Active Agents; D010649:Phenylalanine; D008049:Lipase; D002918:Chymotrypsin; D007052:Ibuprofen