title: The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids.
abstract: The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids is reported. The presence of an N-chloroacetyl group as acyl group in the substrate as well as the use of porcine kidney acylase I as a suitable enzyme component are prerequisites for this resolution process whereby optically active beta-amino acids are formed with high enantioselectivities of >98% ee.
authors.affiliation: Degussa AG, Service Center Biocatalysis, P. O. Box 1345, 63403 Hanau, Germany. harald.groeger@degussa.com
authors.forename: Harald
authors.initials: H
authors.lastname: Groger
authors.forename: Harald
authors.initials: H
authors.lastname: Trauthwein
authors.forename: Stefan
authors.initials: S
authors.lastname: Buchholz
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Drauz
authors.forename: Christiane
authors.initials: C
authors.lastname: Sacherer
authors.forename: Sylvie
authors.initials: S
authors.lastname: Godfrin
authors.forename: Helge
authors.initials: H
authors.lastname: Werner
mesh_terms: D000581:Amidohydrolases / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D000581:Amidohydrolases; C019672:aminoacylase I