title: QSAR study on carbonic anhydrase inhibitors: aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties, with topical activity as antiglaucoma agents.
abstract: Quantitative structure-activity-relationship (QSAR) study on aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl carbonic anhydrase (CA) inhibitors has been carried out topologically using first-order valence connectivity index ((1)chi(v)). Excellent results are obtained against all the three isozymes; CA I, II and IV of the zinc enzyme CA by using indicator parameters along with (1)chi(v).
authors.affiliation: QSAR and Computer Chemical Laboratories, A.P.S. University, Rewa 486003, India.
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Agrawal
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Bano
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.forename: Padmakar V
authors.initials: PV
authors.lastname: Khadikar
mesh_terms: D000287:Administration, Topical; D000818:Animals; D024401:Carbonic Anhydrase I / Q000737:chemistry* / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000737:chemistry* / Q000378:metabolism; D024403:Carbonic Anhydrase III / Q000737:chemistry* / Q000378:metabolism; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D003315:Cornea / Q000201:enzymology / Q000378:metabolism; D005901:Glaucoma / Q000188:drug therapy*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D011804:Quinolines / Q000737:chemistry*; D013441:Sulfinic Acids / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D006571:Heterocyclic Compounds; D007527:Isoenzymes; D011804:Quinolines; D013441:Sulfinic Acids; D013449:Sulfonamides; C403544:8-quinolinesulfonyl chloride; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II; D024403:Carbonic Anhydrase III