title: Light- and singlet oxygen-mediated antifungal activity of phenylphenalenone phytoalexins.
abstract: The light-induced singlet oxygen production and antifungal activity of phenylphenalenone phytoalexins isolated from infected banana plants (Musa acuminata) are reported. Upon absorption of light energy all studied phenylphenalenones sensitise the production of singlet oxygen in polar and non-polar media. Antifungal activity of these compounds towards Fusarium oxysporum is enhanced in the presence of light. These results, together with the correlation of IC50 values under illumination with the quantum yield of singlet oxygen production and the enhancing effect of D2O on the antifungal activity, suggest the intermediacy of singlet oxygen produced by electronic excitation of the phenylphenalenone phytoalexins.
authors.affiliation: Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017-Barcelona, Spain.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Lazzaro
authors.forename: Montserrat
authors.initials: M
authors.lastname: Corominas
authors.forename: Cristina
authors.initials: C
authors.lastname: Martí
authors.forename: Cristina
authors.initials: C
authors.lastname: Flors
authors.forename: Laura R
authors.initials: LR
authors.lastname: Izquierdo
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Grillo
authors.forename: Javier G
authors.initials: JG
authors.lastname: Luis
authors.forename: Santi
authors.initials: S
authors.lastname: Nonell
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000528:radiation effects; D005638:Fruit / Q000737:chemistry; D005670:Fusarium / Q000528:radiation effects; D008027:Light; D015394:Molecular Structure; D010777:Photochemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000528:radiation effects; D012717:Sesquiterpenes; D026082:Singlet Oxygen / Q000737:chemistry; D013729:Terpenes; D000094162:Phytoalexins
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; D013729:Terpenes; D026082:Singlet Oxygen; D000094162:Phytoalexins