title: Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women.
abstract: A therapeutic agent of vitamin K2 is approved for the treatment of osteoporosis in Japan. However, little is known about the efficacy of dietary intake of vitamin K2 for bone health. We compared the effects of various levels of fermented soybeans (Natto) intake, which contains plenty of vitamin K2, on bone stiffness and bone turnover markers in healthy premenopausal women. Seventy-three healthy premenopausal women were randomly divided into four groups matched for age and parity categories. Natto was supplied as follows: Group 1 (no intake), Group 2 (once per month), Group 3 (once per week) and Group 4 (three times per week). Subjects took Natto at a lunch for 1 y, and the stiffness index by quantitative ultrasound and bone turnover markers were assessed at baseline, 6 mo and 1 y. There was no statistical difference in the stiffness index during the 1 y observation. However, bone specific alkaline phosphatase (BAP) in Group 4 was higher than that in Group 3 at 1 y and undercarboxylated osteocalcin (Glu) in Group 4 was significantly lower than those in Groups 1, 2 and 3 at 6 mo. Logistic regression analysis showed that the risk of reduction of bone formation markers declined to 0.07 in Group 4 based on that in Group 1. In premenopausal women who had to keep the stiffness index as high as possible before menopause, Natto intake may have contributed to the promotion of bone formation.
authors.affiliation: Department of Public Health, Kawasaki Medical School, Kurashiki 701-0192, Japan. katsu@med.kawasaki-m.ac.jp
authors.forename: Hironobu
authors.initials: H
authors.lastname: Katsuyama
authors.forename: Seiji
authors.initials: S
authors.lastname: Ideguchi
authors.forename: Masao
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Tatsushige
authors.initials: T
authors.lastname: Fukunaga
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Saijoh
authors.forename: Shigeo
authors.initials: S
authors.lastname: Sunami
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D001696:Biomechanical Phenomena; D015992:Body Mass Index; D016723:Bone Remodeling; D001842:Bone and Bones / Q000502:physiology; D004032:Diet; D005260:Female; D005285:Fermentation; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D010298:Parity; D017697:Premenopause; D045730:Soy Foods; D024482:Vitamin K 2 / Q000008:administration & dosage
chemical_list: D015415:Biomarkers; D024482:Vitamin K 2; D000469:Alkaline Phosphatase