title: Prefrontal cortex function, quasi-physiological stimuli, and synaptic plasticity.
abstract: The prelimbic area of rat medial frontal cortex may be functionally analogous to human/primate dorsolateral prefrontal cortex. This area may be involved in selective attention to the external stimuli and the coupling of the attention to a repertory of actions. It was suggested that this function may rely on a form of long-term memory [Biol. Rev. 77 (2002) 563]. Indeed, during learning of this type of behavior, a portion of prelimbic neurons persistently change their firing characteristics [Prog. Brain Res. 126 (2000) 287]. It is therefore important to study long-term potentiation (LTP) and depression (LTD) in rat prelimbic neurons. In this article, the author first briefly reviews recent findings on the prefrontal cortex function and discusses that the prefrontal cortex may be involved in long-term memory. Second, the author will show some new results which indicate that quasi-physiological patterns of stimuli mimicking prelimbic neuronal activity during behavior can induce LTP in prelimbic pyramidal neuron synapses. These results suggest that prelimbic neuronal activity during behavior may lastingly modify prelimbic synaptic efficacy.
authors.affiliation: Neurobiologie des Processus Adaptatifs UMR7102, Université Paris VI Pierre et Marie Curie, Case 8, Building B, 6th floor, 7 quai St Bernard, 75005 Paris, France. satoru.otani@snv.jussieu.fr
authors.forename: Satoru
authors.initials: S
authors.lastname: Otani
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D013569:Synapses / Q000502:physiology