title: Effects of gadolinium chloride on slowly adapting and rapidly adapting receptors of the rabbit lung.
abstract: Effects of gadolinium chloride, an inhibitor of stretch-activated channels, on the responses of slowly adapting receptors (SARs) and rapidly adapting receptors (RARs) to hyperinflation were investigated. The increase in activity of RARs resulting from sustained elevations of left atrial pressure (LAP) was also assessed with gadolinium chloride application. Action potentials (AP) of SARs and RARs during hyperinflation were recorded from the vagus nerve of anesthetized New Zealand White rabbits before and after application of gadolinium chloride (20mM) directly on the receptor area of the nerve endings. There was a significant reduction of activity in SARs (n = 9) and RARs (n = 7) after application of gadolinium chloride. Activity of RARs (n = 6) increased when the LAP was elevated by 5 and 10 mmHg. This effect was abolished after gadolinium chloride was applied to receptor endings and the activity was restored when gadolinium chloride was removed. This suggests that stretch-activated channels play a role in SARs and RARs activity.
authors.affiliation: Division of Cardiovascular Medicine, TB 172, University of California, One Shield's Avenue, Davis, CA 95616, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Ma
authors.forename: K
authors.initials: K
authors.lastname: Ravi
authors.forename: E M
authors.initials: EM
authors.lastname: Bravo
authors.forename: C T
authors.initials: CT
authors.lastname: Kappagoda
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000287:Administration, Topical; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D005682:Gadolinium / Q000008:administration & dosage*; D006325:Heart Atria; D001239:Inhalation / Q000187:drug effects / Q000502:physiology; D015640:Ion Channel Gating / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009474:Neurons / Q000502:physiology; D011661:Pulmonary Stretch Receptors / Q000187:drug effects*; D011817:Rabbits; D014630:Vagus Nerve / Q000166:cytology / Q000502:physiology
chemical_list: D005682:Gadolinium; C038958:gadolinium chloride