title: Intestinal obstruction associated with oral midodrine.
abstract: We report a case of severe ileus possibly related to midodrine. To our knowledge, this case report is the first one suggesting an inhibitory effect of midodrine on intestinal motility. The potential pharmacological mechanisms leading to this adverse drug reaction are discussed below.
authors.affiliation: Service de Pharmacologie Clinique et Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Faculté de Médecine, Toulouse, France.
authors.forename: Atul
authors.initials: A
authors.lastname: Pathak
authors.forename: Pascaline
authors.initials: P
authors.lastname: Debats
authors.forename: Michel
authors.initials: M
authors.lastname: Galinier
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montastruc
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Senard
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000009:adverse effects*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000503:physiopathology; D008875:Middle Aged; D008879:Midodrine / Q000009:adverse effects*; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D018340:Receptors, Adrenergic, alpha-1; D014662:Vasoconstrictor Agents; D008879:Midodrine