Decreased short- and long-term swallowing problems with altered radiotherapy dosing used in an organ-sparing protocol for advanced pharyngeal carcinoma.
OBJECTIVE
To determine the effect of a reduced radiotherapy dose on short- and long-term swallowing problems after organ-sparing treatment.


METHODS
Prospective case series.


METHODS
Tertiary care referral center.


METHODS
A consecutive sample of 29 patients with advanced oropharyngeal or hypopharyngeal cancer who were treated with intravenous hydroxyurea and concomitant hyperfractionated, accelerated radiotherapy.


METHODS
Initial experience with 74.4 Gy of radiation demonstrated severe long-term swallowing problems, prompting a dose reduction to 60.0 Gy. Eighteen patients were followed up for this study in the 74.4-Gy group, while 11 were in the 60.0-Gy group.


METHODS
Swallowing variables were assessed in both patient groups at 4 months and at 12 months following completion of therapy.


RESULTS
Patient demographics and tumor characteristics were similar in each group, while significant differences were noted in the posttreatment clinical swallowing variables. Persistent severe odynophagia at 4 months (89% [16/18] vs 30% [3/10]) and at 12 months (64% [7/11] vs 11% [1/9]) was greater in the 74.4-Gy group (P =.002). Clinical signs of aspiration were also increased in the 74.4-Gy group, with 81% (13/16) vs 11% (1/9) at 4 months and 60% (6/10) vs 11% (1/9) at 12 months (P<.05). Most striking, however, was the incidence of long-term gastrostomy, with 78% (14/18) of patients receiving 74.4 Gy requiring gastrostomy feedings at 12 months compared with 18% (2/11) in the 60.0-Gy group (P =.002). Local control was unchanged by the altered dosing, with median follow-ups of 43.5 and 24.0 months in the 74.4-Gy and 60.0-Gy groups, respectively.


CONCLUSIONS
Decreased radiation doses can maintain disease control and reduce treatment-related long-term swallowing complications.
Smith
Richard V
RV
Department of Otolaryngology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA. rsmith@montefiore.org
Goldman
S Yedida
SY
Beitler
Jonathan J
JJ
Wadler
Scott S
SS
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003680:Deglutition Disorders / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009519:New York City / Q000453:epidemiology; D009959:Oropharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D013280:Stomatitis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D016019:Survival Analysis; D015431:Weight Loss
D000970:Antineoplastic Agents; D006918:Hydroxyurea