title: Relevance of genetically determined host factors to the prognosis of meningococcal disease.
abstract: To assess the relevance of genetically determined host factors for the prognosis of meningococcal disease, Fc gamma receptor IIA (FcgammaRIIA), the tumor necrosis factor alpha (TNF-alpha) gene promoter region, and plasminogen-activator-inhibitor-1 (PAI-1) gene polymorphisms were studied in 145 patients with meningococcal disease and in 290 healthy controls matched by sex. Distribution of FcgammaRIIA, TNF-alpha, and PAI-1 alleles was not significantly different between patients and controls. Patients with the FcgammaRIIA-R/R 131 allotype scored > or =1 point in the Barcelona prognostic system more frequently than patients with other allotypes (odds ratio, 18.6; 95% confidence interval, 7.1-49.0, P<0.0001), and they had a higher risk of sequelae (odds ratio, 3.5; 95% confidence interval, 1.1-11.7; P=0.03). Fc gamma receptor IIA polymorphism was associated with markers of disease severity, but TNF-alpha and PAI-1 polymorphisms were not.
authors.affiliation: Infectious Diseases Unit, Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avenida Sant Antoni Ma. Claret 167, 08025 Barcelona, Spain. pere.domingo@uab.es
authors.forename: P
authors.initials: P
authors.lastname: Domingo
authors.forename: E
authors.initials: E
authors.lastname: Muñiz-Diaz
authors.forename: M A
authors.initials: MA
authors.lastname: Baraldès
authors.forename: M
authors.initials: M
authors.lastname: Arilla
authors.forename: N
authors.initials: N
authors.lastname: Barquet
authors.forename: R
authors.initials: R
authors.lastname: Pericas
authors.forename: C
authors.initials: C
authors.lastname: Juárez
authors.forename: P
authors.initials: P
authors.lastname: Madoz
authors.forename: G
authors.initials: G
authors.lastname: Vázquez
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008589:Meningococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011336:Probability; D011379:Prognosis; D011401:Promoter Regions, Genetic; D017452:Receptors, IgG / Q000235:genetics* / Q000378:metabolism; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism
chemical_list: D015703:Antigens, CD; C080568:Fc gamma receptor IIA; D005819:Genetic Markers; D017395:Plasminogen Activator Inhibitor 1; D017452:Receptors, IgG; D014409:Tumor Necrosis Factor-alpha