title: Self-immolative dendrimer biodegradability by multi-enzymatic triggering.
abstract: New self-immolative dendritic molecules have been designed and synthesized. The dendrons are built with a multi-enzymatic triggering mechanism, which initiates their biodegradation through a self-immolative chain fragmentation to release a reporter group from the focal point. The dendritic backbone is constructed from polycarbamate linkages, which are stable to hydrolysis and enhance the dendrons' solubility in water. The degradation can readily take place under physiological conditions on enzymatic triggering.
authors.affiliation: School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv 69978, Israel.
authors.forename: Roey J
authors.initials: RJ
authors.lastname: Amir
authors.forename: Doron
authors.initials: D
authors.lastname: Shabat
mesh_terms: D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D016503:Drug Delivery Systems; D015195:Drug Design; D007700:Kinetics; D046911:Macromolecular Substances / Q000737:chemistry*; D015394:Molecular Structure; D010399:Penicillin Amidase / Q000737:chemistry / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D046911:Macromolecular Substances; D010399:Penicillin Amidase