Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes.
Robertson
R Paul
RP
Pacific Northwest Research Institute, Seattle, Washington 98122, USA. rpr@pnri.org
D000818:Animals; D000975:Antioxidants; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000473:pathology*; D005786:Gene Expression Regulation; D005947:Glucose / Q000633:toxicity*; D006801:Humans; D006943:Hyperglycemia; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism*; D008954:Models, Biological; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
D000975:Antioxidants; D001786:Blood Glucose; D007328:Insulin; D017382:Reactive Oxygen Species; D005947:Glucose