Intestinal obstruction associated with oral midodrine.
We report a case of severe ileus possibly related to midodrine. To our knowledge, this case report is the first one suggesting an inhibitory effect of midodrine on intestinal motility. The potential pharmacological mechanisms leading to this adverse drug reaction are discussed below.
Pathak
Atul
A
Service de Pharmacologie Clinique et Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Faculté de Médecine, Toulouse, France.
Debats
Pascaline
P
Galinier
Michel
M
Montastruc
Jean-Louis
JL
Senard
Jean-Michel
JM
D000316:Adrenergic alpha-Agonists / Q000009:adverse effects*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000503:physiopathology; D008875:Middle Aged; D008879:Midodrine / Q000009:adverse effects*; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
D000316:Adrenergic alpha-Agonists; D018340:Receptors, Adrenergic, alpha-1; D014662:Vasoconstrictor Agents; D008879:Midodrine