title: Arthropathies and thyroid diseases.
abstract: OBJECTIVE
  Improvement of articular symptoms following thyroidectomy has often been observed in patients with an association of thyroid and joint diseases. An assessment has therefore been made of the types of arthropathy thus benefited and the anatomopathological features of the thyroid in patients with concomitant joint diseases. An account is given of the arthropathies associated with nontoxic nodular goitre (NTG).
  
  
  METHODS
  Three cell markers are examined to identify immunocytokine elements differentiating thyroid diseases.
  
  
  RESULTS
  Immunohistochemical examination shows extravasal lymphocyte infiltrates; thyrocytes were negative for HLA-Cl II, CD38 and IL-6R, and only dim-positive for HLA-Cl I. Endothelial cells were positive for HLA-Cl I and II and CD38, and negative for IL-6R. The lymphocyte were positive for HLA-Cl I, HLA-Cl II and CD38, but negative for IL-6R. The follow-up of 6 thyroidectomised patients disclosed improvement in joint pain and remission of rheumatoid arthritis and spondylarthritis. Association of nodular goitre with arthro-pathies is demonstrated.
  
  
  CONCLUSIONS
  Arthritis and arthralgia are frequent in patients with thyroid diseases, we particularly found the association with MHNG and Hurthle cell adenoma. Arthritis and arthralgia quickly improve after thyroidectomy. Immunohistochemical NTG thyrocytes are still normal cells (HLA-Cl II negative) by contrast with their HLA-Cl II positivity in autoimmune thyroiditis.
authors.affiliation: Rheumatology Unit, Department of Internal Medicine, Molinette Hospital, University of Turin, Turin, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Longato
authors.forename: R P
authors.initials: RP
authors.lastname: Tarocco
authors.forename: A
authors.initials: A
authors.lastname: Anania
authors.forename: D
authors.initials: D
authors.lastname: Corino
authors.forename: L
authors.initials: L
authors.lastname: Quaranta
authors.forename: L
authors.initials: L
authors.lastname: Perotti
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000032:analysis; D051997:ADP-ribosyl Cyclase 1; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018771:Arthralgia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D001168:Arthritis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D042783:Endothelial Cells / Q000737:chemistry; D005260:Female; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006044:Goiter, Nodular / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D019947:Receptors, Interleukin-6 / Q000032:analysis; D013965:Thyroidectomy
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D008562:Membrane Glycoproteins; D019947:Receptors, Interleukin-6; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1