The production and localization of GTP-bound ran in mitotic mammalian tissue culture cells.
The RanGTPase system has multiple functions in both interphase and mitosis. Extensive studies of Ran-driven nucleocytoplasmic transport have contributed significantly toward our understanding of how RanGTP is produced, hydrolyzed, and localized in interphase. However, there is still a lack of understanding about how this system operates in mitosis. Recent advances have begun to shed light on how RanGTP is produced and localized in mitotic mammalian cells.
Li
Hoi-Yeung
HY
Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA.
Zheng
Yixian
Y
D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000737:chemistry; D006160:Guanosine Triphosphate / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D020931:ran GTP-Binding Protein / Q000378:metabolism*
D006160:Guanosine Triphosphate; D020931:ran GTP-Binding Protein