Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia.
We studied the cognitive improving and cerebral protective constituents in the roots of Polygala tenuifolia Willdenow, a well-known Chinese traditional medicine prescribed for amnesia, neurasthenia, palpitation, noctural emission and insomnia. Tenuifoliside B (1), which is one of the acylated oligosaccharides in the roots of P. tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ameliorative effect on the scopolamine-induced impairment of performance in passive avoidance task in rats. Compound 1 significantly enhanced oxotremorine-induced tremors in mice, suggesting that it ameliorated the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system. These findings show that compound 1 has cognitive improving and cerebral protective effects.
Ikeya
Yukinobu
Y
Research Division, Tsumura & Co., Ibaraki, Japan. ikeya_yukinobu@mail.tsumura.co.jp
Takeda
Shigefumi
S
Tunakawa
Mitsuo
M
Karakida
Humito
H
Toda
Kouin
K
Yamaguchi
Takuji
T
Aburada
Masaki
M
D000215:Acylation / Q000187:drug effects; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002534:Hypoxia, Brain / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D031801:Polygala; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D009844:Oligosaccharides