High-dose granulocyte colony-stimulating factor mobilizes a higher proportion of early CD34(+) CD33(-) hemopoietic progenitors in children receiving treatment for solid tumors.
A relationship between dose of granulocyte colony-stimulating factor (G-CSF) and maturational stage of the progenitors mobilized in healthy adult donors has been suggested. In this study we characterize the progenitors mobilized by 2 different dosages of G-CSF in children receiving autologous grafts after intensive treatment for solid tumors.
Ortín
Miguel
M
Mathew
Leni G
LG
Patel
Soonie R
SR
Millar
Barbara
B
Pandya
Nikki
N
Treleaven
Jennifer
J
D000328:Adult; D015703:Antigens, CD; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; D002648:Child; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology; D063268:Sialic Acid Binding Ig-like Lectin 3
D015703:Antigens, CD; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D063268:Sialic Acid Binding Ig-like Lectin 3; D016179:Granulocyte Colony-Stimulating Factor