Effect of arsenic (AsIII) on glutathione-dependent enzymes in liver and kidney of the freshwater fish Channa punctatus.
The possible role of glutathione-dependent enzymes in the liver and kidney of the freshwater fish Channa punctatus has been studied after exposure to arsenic trioxide for different durations. Activities of glutathione-S-transferases, glutathione peroxidase, glutathione reductase, and catalase decreased in the liver and kidney as a result of the initial increase in arsenic concentration in the liver and kidney. However, during longer exposures, a decline in arsenic concentration corresponded with improved enzyme activity. Because arsenic manifests its toxicity by inducing oxidative stress, the antioxidant enzymes, especially the glutathione-dependent enzymes, play a protective role in arsenic toxicity.
Allen
Tanu
T
Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut-250004, India.
Rana
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D000818:Animals; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000737:chemistry; D002374:Catalase / Q000378:metabolism; D005880:Gills / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D009132:Muscles / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D010087:Oxides / Q000737:chemistry / Q000633:toxicity*; D010473:Perciformes / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D001152:Arsenicals; D010087:Oxides; D014874:Water Pollutants, Chemical; D002374:Catalase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D000077237:Arsenic Trioxide