Aggressive bladder carcinoma in a child.
The brief report describes an unusual case of high grade bladder neoplasm with divergent differentiation in a 31 month-old child. The presentation included hematuria with tissue fragments and the tumor was confined to the bladder. The tumor behaved aggressively despite radical cystectomy, chemotherapy with agents known to be effective against epithelial and mesenchymal tumors and radiation therapy. Although rare, most malignant bladder neoplasms in children are low grade and present in early stages. Sarcomatoid differentiation in the setting of high-grade urothelial carcinoma portends a poor prognosis.
Lezama-del Valle
Pablo
P
Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Jerkins
Gerald R
GR
Rao
Bhaskar N
BN
Santana
Victor M
VM
Fuller
Christine
C
Merchant
Thomas E
TE
D044383:Black People; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015898:Tomography Scanners, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy