Interaction of polymer aggregates based on stearoyl-poly-N-vinylpyrrolidone with blood components.
Stearoyl-poly-N-vinylpyrrolidone (PVP-stear) of various molecular weights (M(n) = 1500-5500) self-assemble in aqueous medium. Particles prepared from PVP-stear were characterized in terms of shape and size distribution, and the mechanical stability of the particles was studied. The interaction of PVP-stear and its aggregates with blood components was investigated. Aggregates formed by the polymers with M(n) = 1500-3500 in the presence of human serum are stable. The direct lytic action of PVP-stear preparations was studied using sheep and human erythrocytes. The influence of PVP-stear aggregates on the activation of complement system both on classical and alternative pathways was examined. The aggregates prepared from PVP-stear of various molecular weights had no effect on the activation of the complement system.
Villemson
A L
AL
Faculty of Chemistry, Lomonosov Moscow State University, Moscow 119992, Russia.
Kuskov
A N
AN
Shtilman
M I
MI
Galebskaya
L V
LV
Ryumina
E V
EV
Larionova
N I
NI
D000818:Animals; D001769:Blood / Q000378:metabolism*; D003167:Complement Activation / Q000187:drug effects; D004912:Erythrocytes; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008027:Light; D008823:Micelles; D008954:Models, Biological; D008970:Molecular Weight; D010316:Particle Size; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry* / Q000494:pharmacology; D011817:Rabbits; D012542:Scattering, Radiation; D034561:Sheep, Domestic; D013228:Stearates / Q000737:chemistry* / Q000494:pharmacology
D008823:Micelles; D011108:Polymers; D011760:Pyrrolidinones; D013228:Stearates; C488306:stearoyl-poly-N-vinylpyrrolidone