[Encephalopathy and acute renal failure during acyclovir treatment].
BACKGROUND
Adverse neurological and renal effects can occur in patients taking acyclovir. Neurotoxicity of acyclovir results from an accumulation of the antiviral and its metabolites in the bloodstream. This can be observed in the elderly or in patients with chronic renal failure, generally in dialysis patients. Acute renal failure results from intratubular crystallization of acyclovir.


METHODS
A 78-year-old right-handed woman was admitted in an emergency setting for aphasia. Analysis of the cerebrospinal fluid was normal, but herpetic meningo-encephalitis was suspected and intravenous treatment was initiated with acyclovir. After the second infusion, the patient began to suffer from visual hallucinations, confusion and acute renal failure. Herpes PCR was negative in the cerebrospinal fluid, and the adverse drug reactions regressed completely after 72 hours.


CONCLUSIONS
Renal function has to be checked often in patients given acyclovir for appropriate dose titration. Patients recover prompt from the adverse effects at drug withdrawal.
Delluc
A
A
Service de Neurologie, CHU de la Cavale Blanche, Brest, France.
Mocquard
Y
Y
Latour
P
P
Goas
J-Y
JY
D000208:Acute Disease; D000212:Acyclovir / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D020803:Encephalitis, Herpes Simplex / Q000188:drug therapy*; D005260:Female; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology*; D051437:Renal Insufficiency / Q000139:chemically induced*
D000998:Antiviral Agents; D000212:Acyclovir