Gene transfer of interleukin-4 delays acute rejection of splenic allografts in rats.
Spleen transplantation is the treatment of choice for some diseases, such as hemophilia A. However, the risk and intensity of rejection after spleen transplantation is greater and more difficult to control than other types of transplant. In the present study, we demonstrated that perfusion of IL-4 expression plasmids into donor spleens pretransplantation led to overexpression of IL-4 and downregulation of IFN-gamma in situ, associated with delayed acute rejection of the allograft. Gene transfer of IL-4 may represent a potential therapeutic approach to induce tolerance to splenic allografts.
Jiang
H
H
Hepatosplenic Surgery Center of Heilongjiang Province, and the Department of General Surgery, The First Clinical Medical School, Harbin Medical University, Harbin, China.
Liu
C
C
Xu
J
J
Sun
B
B
Pan
S
S
Qiao
H
H
Luo
L
L
Sun
X
X
D000818:Animals; D018014:Gene Transfer Techniques; D006084:Graft Rejection / Q000517:prevention & control*; D015847:Interleukin-4 / Q000235:genetics* / Q000276:immunology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013154:Spleen / Q000637:transplantation*; D014184:Transplantation, Homologous / Q000276:immunology*
D015847:Interleukin-4