[Value of N-acetylcysteine to prevent nephrotoxicity from iodinated contrast agents].
Renal toxicity of contrast agents remains an up-to-date challenge. N'Acetyl cystein is an antioxyde agent which efficacy has been proved in various models of experimental renal ischemia and therefore proposed in the prevention of renal failure due to intravenous iodine contrast media. The Author of this review reports and comments these studies in order to better define indications of N'Acetyl cystein in this clinical context.
Deray
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Service de Néphrologie, Groupe Hospitalier Pitié Salpêtrière, 47-83 boulevard de l'Hôpital, 75651 Paris Cedex 13.
D000111:Acetylcysteine / Q000494:pharmacology / Q000627:therapeutic use*; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D003287:Contrast Media / Q000009:adverse effects*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D012307:Risk Factors; D016896:Treatment Outcome
D000975:Antioxidants; D003287:Contrast Media; D016166:Free Radical Scavengers; D007457:Iodine Radioisotopes; D000111:Acetylcysteine