Cytotoxic-antineoplastic activity of acetyl derivatives of prenylnaphthohydroquinone.
Several acetyl derivatives of prenylnaphthohydroquinone have been synthetized and evaluated for their cytotoxicity against A-549 human lung carcinoma and H-116 human colon carcinoma neoplastic cells. The IC50 values against A-549 are compared with those observed for previously reported unsubstituted derivatives.
Molinari
Aurora
A
Instituto de Química, Pontificia Universidad Católica de Valparaíso, Avenida Brazil 2950, Casilla 4059 Valparaíso, Chile. amolinar@ucv.cl
Oliva
Alfonso
A
del Corral
José María Miguel
JM
Castro
María Angeles
MA
Araya
Claudia
C
García-Grávalos
María Dolores
MD
San Feliciano
Arturo
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D006873:Hydroquinones; D009285:Naphthoquinones; C493261:prenylnaphthohydroquinone