Spectroscopic detection of bladder cancer using near-infrared imaging techniques.
High-contrast imaging of bladder cancer is demonstrated using near-infrared autofluorescence under long-wavelength laser excitation in combination with cross-polarized elastic light scattering. Fresh unprocessed surgical specimens obtained following cystectomy or transurethral resection were utilized and a set of images for each tissue sample was recorded. These images were compared with the histopathology of the tissue sample. The experimental results indicate that the intensity of the near-infrared emission as well as that of the cross-polarized backscattered light was considerably different in cancer tissues than in that of the contiguous nonneoplastic tissues, allowing an accurate delineation of a tumor's margins.
Demos
Stavros G
SG
Lawrence Livermore National Laboratory, Livermore, California 94551University of California Davis Medical School, Medical Center, Sacramento, California 95817, USA. demos1@llnl.gov
Gandour-Edwards
Regina
R
Ramsamooj
Rajen
R
deVere White
Ralph
R
D005240:Feasibility Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000379:methods*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology