title: Oesophageal carcinoma and refractory idiopathic thrombocytopenic purpura: a challenging combination.
abstract: We report the case of a 72-year-old lady who presented with fatigue and bruising. Initial investigations were compatible with iron deficiency anaemia and idiopathic thrombocytopenic purpura (ITP). The anaemia and recent heartburn symptoms led to endoscopy, which revealed an extensive oesophageal squamous cell carcinoma. The tumour was inoperable due to local extension and the patient was not deemed fit enough for aggressive chemotherapy. A course of radical local radiotherapy was given. The patient's ITP, which had initially been responsive to high-dose intravenous immunoglobulin, subsequently became refractory to all therapeutic modalities. The patient developed significant dysphagia but therapeutic options were limited due to her severe thrombocytopenia. The patient eventually died from a combination of gastrointestinal and intrapulmonary haemorrhage. This case is of interest for two reasons. First, the development of refractory ITP appeared to mirror the progression of the carcinoma, and to our knowledge this is the first case of ITP associated with oesophageal carcinoma. Second, despite recent endoscopic advances in palliating oesophageal tumours, this case highlights the difficulties that can still occur.
authors.affiliation: Department of Gastroenterology, Royal Hampshire County Hospital, Winchester, UK.
authors.forename: James D
authors.initials: JD
authors.lastname: Shutt
authors.forename: C Jason
authors.initials: CJ
authors.lastname: Mainwaring
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Davis
authors.forename: Christopher M
authors.initials: CM
authors.lastname: James
authors.forename: Hugh A
authors.initials: HA
authors.lastname: Shepherd
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D004938:Esophageal Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D017211:Treatment Failure