title: Peribysins A-D, potent cell-adhesion inhibitors from a sea hare-derived culture of Periconia species.
abstract: Peribysins A-D 1-4, including a new type of furanofuran, have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai, and their relative stereostructures have been elucidated on the basis of NMR spectral analyses. All these metabolites potently inhibited the adhesion of human-leukemia HL-60 cells to HUVEC. The activity of compound 4, exhibiting the most potent inhibitory activity, was 380 times as potent as herbimycin A (standard).
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki,Osaka 569-1094, Japan. yamada@gly.oups.co.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Masashi
authors.initials: M
authors.lastname: Iritani
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Minoura
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kawai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Numata
mesh_terms: D000818:Animals; D001048:Aplysia / Q000382:microbiology; D001203:Ascomycota / Q000737:chemistry* / Q000302:isolation & purification; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D005663:Furans; C492944:peribysin A; C492943:peribysin B; C492942:peribysin C; C492941:peribysin D