Risk factors for cardiovascular disease in pediatric renal transplant recipients.
About 1,000 children develop end-stage renal disease (ESRD) each year in the United States and about 5,000 children are currently receiving dialysis. Children who develop ESRD are eligible to receive renal replacement therapy, including renal transplantation. There are inherent risks associated with transplantation, including renal insufficiency, infections, post-transplant lymphoproliferative disorder, and cardiovascular disease (CVD). Potential risk factors for CVD in pediatric renal transplant recipients include renal insufficiency, hyperlipidemia, hyperhomocysteinemia, inflammation, malnutrition, anemia, and hyperglycemia/insulin resistance. Despite evidence that many children may possess various risk factors for CVD post-renal transplantation, there are very few studies that have attempted to assess the link between these risk factors and CVD in pediatric renal transplant recipients.
Silverstein
Douglas M
DM
Louisiana State University Health Sciences Center, Department of Pediatrics, Children's Hospital, New Orleans, LA, USA. dsilve@lsuhsc.edu
D000740:Anemia / Q000150:complications; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D020138:Hyperhomocysteinemia / Q000150:complications; D006949:Hyperlipidemias / Q000150:complications; D007249:Inflammation / Q000150:complications; D016030:Kidney Transplantation; D044342:Malnutrition / Q000150:complications; D011182:Postoperative Care; D051437:Renal Insufficiency / Q000150:complications; D012307:Risk Factors