title: Measure profile surrogates: a method to validate the performance of epileptic seizure prediction algorithms.
abstract: In a growing number of publications it is claimed that epileptic seizures can be predicted by analyzing the electroencephalogram (EEG) with different characterizing measures. However, many of these studies suffer from a severe lack of statistical validation. Only rarely are results passed to a statistical test and verified against some null hypothesis H0 in order to quantify their significance. In this paper we propose a method to statistically validate the performance of measures used to predict epileptic seizures. From measure profiles rendered by applying a moving-window technique to the electroencephalogram we first generate an ensemble of surrogates by a constrained randomization using simulated annealing. Subsequently the seizure prediction algorithm is applied to the original measure profile and to the surrogates. If detectable changes before seizure onset exist, highest performance values should be obtained for the original measure profiles and the null hypothesis. "The measure is not suited for seizure prediction" can be rejected. We demonstrate our method by applying two measures of synchronization to a quasicontinuous EEG recording and by evaluating their predictive performance using a straightforward seizure prediction statistics. We would like to stress that the proposed method is rather universal and can be applied to many other prediction and detection problems.
authors.affiliation: John-von-Neumann Institute for Computing, Forschungszentrum Jülich, 52425 Jülich Germany. t.kreuz@fz.juelcih.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Kreuz
authors.forename: Ralph G
authors.initials: RG
authors.lastname: Andrzejak
authors.forename: Florian
authors.initials: F
authors.lastname: Mormann
authors.forename: Alexander
authors.initials: A
authors.lastname: Kraskov
authors.forename: Harald
authors.initials: H
authors.lastname: Stögbauer
authors.forename: Christian E
authors.initials: CE
authors.lastname: Elger
authors.forename: Klaus
authors.initials: K
authors.lastname: Lehnertz
authors.forename: Peter
authors.initials: P
authors.lastname: Grassberger
mesh_terms: D000465:Algorithms; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity