Effect of mental and physical stress on platelet activation markers in depressed patients and healthy subjects: a pilot study.
Depression represents an independent risk factor for developing ischemic heart disease, with platelet hyperactivity possibly serving as an important mediator of this association. In this pilot study we analyzed platelet surface activation markers in response to two stimuli, mental stress and physical activity. Using flow cytometry, we quantified the presence of two functional activation-dependent glycoprotein receptors on platelets' surface (P-selectin, GP53). Platelet reactivity was assessed as the difference in markers' fluorescence intensity before and after stimulation. We included 10 depressed psychiatric inpatients and 10 age- and sex-matched healthy subjects in our study. There was a significant rise in platelet activation markers in both groups associated with the stress protocol. When the effect of stressors was analyzed separately, strenuous physical activity was found to lead to a significant rise in platelet activation markers in depressed patients but not in healthy subjects, although values indicated a higher baseline level of activation in healthy subjects. These preliminary results lend partial support to the hypothesis of an exaggerated platelet reactivity after physical activity in depression, thus possibly contributing to an increased cardiovascular risk in this disorder.
Lederbogen
Florian
F
Central Institute of Mental Health, J5, 68159 Mannheim, Germany. lederbog@zi-mannheim.de
Baranyai
Reka
R
Gilles
Maria
M
Menart-Houtermans
Barbara
B
Tschoepe
Diethelm
D
Deuschle
Michael
M
D001792:Blood Platelets / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005434:Flow Cytometry; D005453:Fluorescence; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010865:Pilot Projects; D012307:Risk Factors; D013315:Stress, Psychological / Q000097:blood*
D019007:P-Selectin