title: Characteristics of patients diagnosed with AIDS shortly after first detection of HIV antibodies in Lyon University hospitals from 1985 to 2001.
abstract: A diagnosis of AIDS shortly after the detection of HIV antibodies suggests a long-lasting course of the disease without care. The factors associated with a short delay between the initial HIV-1-positive test and the first AIDS-defining event were identified in 1901 patients from 1985 to 2001 in Lyon University hospitals. A total of 576 individuals (30.3%) had an interval of </=3 months between the detection of HIV infection and AIDS. The factors independently associated with a delay of </=3 months were: age from 30 to 44 years [odds ratio (OR) 2.5; 95% confidence interval (CI) 1.9-3.2]; age from 45 to 59 years (OR 5.6; 95% CI 3.9-7.8); age >/=60 years (OR 4.5; 95% CI 2.5-8.1), compared to those<30 years old; heterosexuality (OR 2.4; 95% CI 1.6-3.4); injection drug use (OR 2.1; 95% CI 1.5-2.7); and other exposures (OR 2.4; 95% CI 1.6-3.4), compared to homosexual exposure; two opportunistic infections at AIDS (OR 1.8; 95% CI 1.4-2.4) compared to one; and Pneumocystis carinii pneumonia as initial AIDS event (OR 2.6; 95% CI 1.8-3.7), compared to Kaposi's sarcoma. These results provide opportunities to refocus local public health interventions to reduce delayed access to care.
authors.affiliation: Department of Hygiene, Epidemiology and Prevention, Edouard Herriot Hospital, Lyon, France.
authors.forename: D
authors.initials: D
authors.lastname: Baratin
authors.forename: E
authors.initials: E
authors.lastname: Marceillac
authors.forename: C
authors.initials: C
authors.lastname: Trepo
authors.forename: L
authors.initials: L
authors.lastname: Cotte
authors.forename: D
authors.initials: D
authors.lastname: Peyramond
authors.forename: C
authors.initials: C
authors.lastname: Chidiac
authors.forename: J-L
authors.initials: JL
authors.lastname: Touraine
authors.forename: J-M
authors.initials: JM
authors.lastname: Livrozet
authors.forename: J
authors.initials: J
authors.lastname: Fabry
authors.forename: R
authors.initials: R
authors.lastname: Allard
authors.forename: P
authors.initials: P
authors.lastname: Vanhems
mesh_terms: D015492:AIDS Serodiagnosis; D017088:AIDS-Related Opportunistic Infections; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000635:transmission; D000328:Adult; D000367:Age Factors; D005260:Female; D015497:HIV-1; D020010:Heterosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011020:Pneumonia, Pneumocystis; D012307:Risk Factors; D012737:Sex Factors; D015819:Substance Abuse, Intravenous; D013997:Time Factors