Enantioseparation of tiropramide by HPLC.
Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.
Ryoo
Jae Jeong
JJ
Department of Chemistry, Graduate School, Kyungpook National University, 702-701 Daegu, Korea. jjryoo@iastate.edu
Heo
Kyu Sung
KS
Choi
Eun-Soon
ES
Park
Jung Hag
JH
Lee
Wonjae
W
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D010276:Parasympatholytics / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D010276:Parasympatholytics; D014443:Tyrosine; C031173:tiropramide