Nuclear receptors and disease: androgen receptor.
The death of cells by apoptosis is a fundamental event in development and the maintenance of cell homoeostasis. The other side of the coin, however, is that excessive cell death by apoptosis or the lack of apoptosis is often the driving force of many diseases. Whereas reduced apoptosis sensitivity is a basic characteristic of many tumour cells, accelerated tissue cell death and loss of tissue functions is the underlying cause of many auto-immune and inflammatory diseases.
Gottlieb
Bruce
B
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montréal, Québec, Canada H3T 2E1. bruce.gottlieb@mcgill.ca
Beitel
Lenore K
LK
Wu
Jianhui
J
Elhaji
Youssef A
YA
Trifiro
Mark
M
D000818:Animals; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D010641:Phenotype; D011944:Receptors, Androgen / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000235:genetics / Q000502:physiology
D011944:Receptors, Androgen; D018160:Receptors, Cytoplasmic and Nuclear