A prospective evaluation of the effects of salpingectomy on endometrial lymphocyte clusters in patients with hydrosalpinges.
OBJECTIVE
To investigate the effect of hydrosalpinges on embryo implantation.


METHODS
Prospective study.


METHODS
Private fertility and university hospitals.


METHODS
Eighteen patients with unilateral or bilateral hydrosalpinges who underwent salpingectomy.


METHODS
Pre- and posttreatment endometrial biopsies for immunohistochemical evaluation.


METHODS
Pre- and posttreatment lymphocyte populations in endometrial samples, evaluated by immunohistochemical identification.


RESULTS
Endometrial samples from pretreatment exhibited small lymphocytic clusters of CD3+, CD8+, CD4+, granzyme B positive, and CD56+. After salpingectomy, the numbers of cluster lesions were significantly decreased.


CONCLUSIONS
Because a characteristic distribution of lymphocytes in endometrium with hydrosalpinges was found, activation of T/NK (natural killer) lymphocytes in endometrium might be involved in the impairment of embryo implantation in cases of hydrosalpinges.
Ito
Chikako
C
Narita Hospital, Nagoya, Japan. itom@med.nagoya-u.ac.jp
Ito
Masafumi
M
Itakura
Atsuo
A
Asai
Masako
M
Narita
Osamu
O
Mizutani
Shigehiko
S
D000328:Adult; D004717:Endometrium / Q000473:pathology*; D005184:Fallopian Tube Diseases / Q000473:pathology* / Q000601:surgery*; D005187:Fallopian Tubes / Q000601:surgery*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007694:Killer Cells, Natural / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology*; D011184:Postoperative Period; D011446:Prospective Studies; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000473:pathology