[Neovascularization after ischemic stroke].
After ischemic stroke, there is neovascularization around the infarcted area, which is called penumbra. Angiogenesis and arteriogenesis are responsible for the new vessel formation. Until recently, vasculogenesis has been proved to involve mechanisms in postischemic neovascularization, which was thought to be restricted to embryonic development. New blood vessels' formation is a complex pathologic process after ischemic stroke, in which many factors are properly involved. There are factors stimulating neovascularization, such as vascular endothelial growth factor, platelet-derived growth factor, basic fibroblast growth factor and angiopoietin; there are also factors inhibiting neovascularization, such as thrombospondin. Functional recovery was found after stroke, which may contribute to angiogensis in the periinfarct tissue. Thus, therapeutic angiogenesis has been initially studied in animal models, but there is still a long way to go for therapeutic angiogenesis to be used in the treatment of stroke patient.
Hu
Xiangshu
X
Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, China.
Zhou
Dong
D
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D042683:Angiopoietin-1 / Q000378:metabolism; D001921:Brain / Q000098:blood supply*; D020520:Brain Infarction / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D018919:Neovascularization, Physiologic; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
D043925:Angiogenesis Inducing Agents; D042683:Angiopoietin-1; D010982:Platelet-Derived Growth Factor; D042442:Vascular Endothelial Growth Factors