title: Gonadotropin treatment of an azoospermic patient with a Y-chromosome microdeletion.
abstract: OBJECTIVE
  To report on the treatment with recombinant FSH of an azoospermic normogonadotropic patient with a Y-chromosome microdeletion.
  
  
  METHODS
  Case report.
  
  
  METHODS
  An assisted reproduction center.
  
  
  METHODS
  A 32-year-old patient with azoospermia.
  
  
  METHODS
  Histological testicular biopsy, Y-chromosome screening, FSH treatment, and intracytoplasmic sperm injection.
  
  
  METHODS
  Fertilization, embryo development, pregnancy, and delivery.
  
  
  RESULTS
  After 6 months of treatment with gonadotropins, a small number of spermatozoa were found in the patient's ejaculate and used for IVF, resulting in a successful twin pregnancy and the delivery of two healthy girls.
  
  
  CONCLUSIONS
  In this study, treatment with gonadotropins promoted the spermatogenesis process and led to the production of spermatozoa in a normogonadotropic azoospermic patient.
authors.affiliation: Istituto Europeo Medicina della Riproduzione Abruzzese, Spatocco Hospital, Chieti, Italy. selmanha@yahoo.com
authors.forename: Helmy A
authors.initials: HA
authors.lastname: Selman
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cipollone
authors.forename: Liborio
authors.initials: L
authors.lastname: Stuppia
authors.forename: Mariella
authors.initials: M
authors.lastname: De Santo
authors.forename: Karl
authors.initials: K
authors.lastname: Sterzik
authors.forename: Imam
authors.initials: I
authors.lastname: El-Danasouri
mesh_terms: D000328:Adult; D041322:Chromosomes, Human, Y; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D017353:Gene Deletion; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009845:Oligospermia / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy; D011272:Pregnancy, Multiple; D020554:Sperm Injections, Intracytoplasmic; D013091:Spermatogenesis / Q000187:drug effects; D014427:Twins
chemical_list: D006728:Hormones; D005640:Follicle Stimulating Hormone