title: [Evidence-based prevention of cholecystolithiasis].
abstract: Evidence based prevention of cholecystolithiasis. Cholesterol cholelithiasis is one of the most common and expensive gastroenterological diseases. Beside common exogenous risk factors, recent molecular genetic studies have identified genetic risk factors for both cholesterol and pigment stone formation. Examples are low phospholipid-associated cholelithiasis due to mutations of the gene encoding the hepatocanalicular phosphatidylcholine transporter, and pigment stones in association with mutations of the ileal bile salt transporter gene. Evidence-based options for primary prevention of cholecystolithiasis include physical activity, slow weight reduction, regular vitamin C supplementation, and moderate coffee consumption. The ongoing genome projects provide the basis for future epidemiological studies of human gallstone (LITH) genes, which might offer new prospects for individual risk assessment and prevention of gallstones.
authors.affiliation: Medizinische Klinik III, Universitätsklinikum Aachen, RWTH Aachen, Aachen.
authors.forename: Frank
authors.initials: F
authors.lastname: Lammert
authors.forename: Siegfried
authors.initials: S
authors.lastname: Matern
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage; D001660:Biliary Tract Diseases / Q000517:prevention & control; D002352:Carrier Proteins / Q000235:genetics; D041761:Cholecystolithiasis / Q000235:genetics / Q000517:prevention & control*; D003069:Coffee / Q000009:adverse effects; D003085:Colic / Q000517:prevention & control; D019317:Evidence-Based Medicine; D015444:Exercise; D005706:Gallbladder Neoplasms / Q000517:prevention & control; D006801:Humans; D049294:Phospholipid Transfer Proteins; D011322:Primary Prevention / Q000379:methods*; D012307:Risk Factors; D015431:Weight Loss
chemical_list: D002352:Carrier Proteins; D003069:Coffee; D049294:Phospholipid Transfer Proteins; D001205:Ascorbic Acid