title: Immunotoxicological effects of dermal application of scum of waste crankcase oil in mice.
abstract: The scum of waste crankcase oil (SWCO) forms due to weathering of waste crankcase oil, deposited on the surface of water bodies. It is known to attach to the feathers of aquatic birds and cause toxicity to the eggs of nestling birds. The water bodies contaminated with SWCO can also be a source of toxicity to the human beings and animals entering such bodies. Since SWCO used in the present study had an appreciable content of heavy metals like Zn, Pb, Cd, Mn, Cr and Ni, the present investigation was undertaken to study a probable effect on immune system of mice. Animals treated with SWCO at a dose of 0.5, 1.0, 2.0, or 4.0 g/kg body weight for 28 days, had no effect on the weight gain of vital organs. A depressing effect was observed on the cell population of spleen and thymus. The number of primary antibody (IgM) producing cells was significantly depressed in spleen. The IgM antibody titer of serum, reduction of NBT dye by peritoneal exudat cells and mounting of delayed hypersensitivity response were not affected. In view of above immunotoxic effects of SWCO, the waste crankcase oil should be carefully disposed of, away from water bodies.
authors.affiliation: Immunotoxicology Laboratory, Industrial Toxicology Research Centre, Lucknow 226 001, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Khanna
authors.forename: Ram K S
authors.initials: RK
authors.lastname: Dogra
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D051379:Mice; D009821:Oils / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010578:Petroleum / Q000633:toxicity*; D012867:Skin / Q000187:drug effects* / Q000276:immunology
chemical_list: D009821:Oils; D010578:Petroleum