title: Fabrication of porous hollow silica nanoparticles and their applications in drug release control.
abstract: Preparation and characterization of porous hollow silica nanoparticles (PHSN) for controlled release applications were investigated. Through orthogonally designed experiments, the optimal synthesis conditions for the preparation of PHSN were obtained and the produced PHSN were characterized by BET, SEM, TEM and IR. Scanning and transmission electron microscopy images revealed their hollow shell-core structure and also demonstrated that the size and shape of PHSN are determined by the templating CaCO3 nanoparticles. The produced PHSN were applied as a carrier to study the controlled release behaviors of Brilliant Blue F (BB), which was used as a model drug. Being loaded into the inner core and on the surfaces of the nanoparticles, BB was released slowly into a bulk solution for about 1140 min as compared to only 10 min for the normal SiO2 nanoparticles, thus exhibited a typical sustained release pattern without any burst effect. In addition, higher BET of the carriers, lower pH value and lower temperature prolonged BB release from PHSN, while stirring speed showed little influence on the release behavior. It showed that PHSN have a promising future in controlled drug delivery applications.
authors.affiliation: Key Lab for Nanomaterials, Ministry of Education, Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Zhu-Zhu
authors.initials: ZZ
authors.lastname: Li
authors.forename: Li-Xiong
authors.initials: LX
authors.lastname: Wen
authors.forename: Lei
authors.initials: L
authors.lastname: Shao
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Chen
mesh_terms: D001557:Benzenesulfonates / Q000737:chemistry; D002119:Calcium Carbonate / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D013696:Temperature
chemical_list: D001557:Benzenesulfonates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012822:Silicon Dioxide; D002119:Calcium Carbonate; C006796:brilliant blue