Inhibitory effect of medicinal herbs against RNA and DNA viruses.
Fifteen Argentine medicinal plants were tested for their antiviral activity in vitro against herpes simplex viruses types 1 and 2 (HSV-1 and 2), bovine viral diarrhoea virus type 1 (BVDV-1), influenza virus type A (Inf A) and human immunodeficiency virus type 1 (HIV-1). Antiviral activity was evaluated by a reduction in cytopathic effect, plaque-forming units and p24 HIV-1 antigen. The Selective Index of the active extract (SI(extract) = CC50(extract)/EC50(extract)) of Coronopus didymus (SI(extract) = 110.7), Juglans australis (SI(extract) = 8.1) and Lippia alba (SI(extract) = 19.2) against BVDV-1, HSV-1 and influenza A virus, respectively, justify a further analysis. None of the seven plants assayed against HIV-1 displayed any antiviral activity. The results of this study justify the continuing isolation and characterization of the antiviral components present.
Ruffa
María Julieta
MJ
Universidad de Buenos Aires, Argentina.
Wagner
Marcelo Luis
ML
Suriano
Mónica
M
Vicente
Carlos
C
Nadinic
Jelena
J
Pampuro
Sandra
S
Salomón
Horacio
H
Campos
Rodolfo Héctor
RH
Cavallaro
Lucía
L
D000818:Animals; D001118:Argentina; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000188:drug therapy*; D002417:Cattle; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D018139:Simplexvirus / Q000187:drug effects; D014709:Vero Cells; D010948:Viral Plaque Assay
D010936:Plant Extracts