title: Comparison of fentanyl versus meperidine for analgesia in pediatric gastrointestinal endoscopy.
abstract: This study compared the safety and efficacy of fentanyl and meperidine for analgesia in pediatric gastrointestinal endoscopy. In a double-blind, randomized trial, 24 patients (11 males) received either fentanyl (1 microg/kg) or meperidine (1 mg/kg). These analgesics were administered in unmarked syringes by an investigator who did not participate in the procedure or in the evaluation of the patient's sedation. There were 17 Caucasians and 7 African-Americans whose mean age was 10.4 +/- 4.4 years. Thirteen patients received meperidine and 11 received fentanyl. Midazolam was given to all patients as needed to provide sufficient sedation for the procedure. Study subjects underwent EGD (n = 17) or colonoscopy (n = 7). There were no differences as assessed by patient, endoscopist, or assistant for tolerance, discomfort, procedure ease, recovery time, complications, heart rate, blood pressure, or oxygen saturation. We conclude that meperidine and fentanyl are equally effective in providing analgesia for pediatric gastrointestinal endoscopy.
authors.affiliation: Department of Pediatrics and Division of Pediatric Gastroenterology, University of South Alabama, Mobile, Alabama, USA.
authors.forename: Sabina
authors.initials: S
authors.lastname: Ali
authors.forename: D Lyn
authors.initials: DL
authors.lastname: Davidson
authors.forename: David A
authors.initials: DA
authors.lastname: Gremse
mesh_terms: D000293:Adolescent; D000701:Analgesics, Opioid; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D016145:Endoscopy, Digestive System; D005260:Female; D005283:Fentanyl; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008614:Meperidine; D008874:Midazolam; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D008614:Meperidine; D008874:Midazolam; D005283:Fentanyl