title: Cytogenetic evaluation of extractable agents from airborne particulate matter generated in the city of Catania (Italy).
abstract: In order to document cytogenetic damage associated with air pollution and, possibly, with health effects in the city of Catania, Sicily (Italy), we analyzed the induction of chromosomal aberrations by extractable agents from airborne particulate matter in a Chinese hamster epithelial liver (CHEL) cells. These cells retain their metabolic competence to activate different classes of promutagens/procarcinogens into biologically active metabolites. Airborne particulate matter was obtained from two stationary samplers (stations I and II) in two areas endowed by an elevated car transit in the centre of Catania. The results obtained clearly indicated that airborne particulate matter from both stations I and II proved to be clastogens in CHEL cells but not in Chinese hamster ovary (CHO) cells without metabolic activation, indicating that airborne particulate mixtures need to be metabolically converted before exerting their genotoxic potential. On the basis of these results we can assert that the test system employed to identify the cytogenetic potential of airborne particulate matter is useful and profitable for environmental control, and helpful to plan specific actions aimed at reducing the hazards derived from exposure to polluted air.
authors.affiliation: Dipartimento di Biologia Animale M. La Greca, Universita'di Catania, Via Androne 81, 95124 Catania, Italy. mottasal@unict.it
authors.forename: Salvatore
authors.initials: S
authors.lastname: Motta
authors.forename: Concetta
authors.initials: C
authors.lastname: Federico
authors.forename: Salvatore
authors.initials: S
authors.lastname: Saccone
authors.forename: Vito
authors.initials: V
authors.lastname: Librando
authors.forename: Pasquale
authors.initials: P
authors.lastname: Mosesso
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000139:chemically induced*; D002947:Cities; D006224:Cricetinae; D003412:Cricetulus; D020732:Cytogenetic Analysis; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring; D007558:Italy; D009153:Mutagens / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D009153:Mutagens