Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells.
New structure-activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.
Ivanova
Diana
D
Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France.
Rossin
Aurélie
A
Gronemeyer
Hinrich
H
Valla
Alain
A
Cartier
Dominique
D
Le Guillou
Régis
R
Labia
Roger
R
D016923:Cell Death; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D006801:Humans; D006838:Hydrocarbons; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D012176:Retinoids / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D006838:Hydrocarbons; D012176:Retinoids; C030011:carbene; D008697:Methane