title: [First clinical experience with extended planning and navigation in an interventional MRI unit].
abstract: OBJECTIVE
  To present an advanced concept for patient-based navigation and to report on our first clinical experience with interventions in the cranium, of soft-tissue structures (breast, liver) and in the musculoskeletal system.
  
  
  METHODS
  A PC-based navigation system was integrated into an existing interventional MRI environment. Intraoperatively acquired 3D data were used for interventional planning. The information content of these reference data was increased by integration of additional image modalities (e. g., fMRI, CT) and by color display of areas with early contrast media enhancement. Within 18 months, the system was used in 123 patients undergoing interventions in different anatomic regions (brain: 64, paranasal sinus: 9, breast: 20, liver: 17, bone: 9, muscle: 4). The mean duration of 64 brain interventions was compared with that of 36 procedures using the scanner's standard navigation.
  
  
  RESULTS
  In contrast with the continuous scanning mode of the MR system (0.25 fps), the higher quality as well as the real time display (4 fps) of the MR images reconstructed from the 3D reference data allowed adequate hand-eye coordination. With our system, patient movement and tissue shifts could be immediately detected intraoperatively, and, in contrast to the standard procedure, navigation safely resumed after updating the reference data. The navigation system was characterized by good stability, efficient system integration and easy usability. Despite additional working steps still to be optimized, the duration of the image-guided brain tumor resections was not significantly longer.
  
  
  CONCLUSIONS
  The presented system combines the advantage of intraoperative MRI with established visualization, planning, and real time capabilities of neuronavigation and can be efficiently applied in a broad range of non-neurosurgical interventions.
authors.affiliation: Klinik und Poliklinik für Diagnostische Radiologie, Universitätsklinikum Leipzig. moche@medizin.uni-leipzig.de
authors.forename: M
authors.initials: M
authors.lastname: Moche
authors.forename: A
authors.initials: A
authors.lastname: Schmitgen
authors.forename: J P
authors.initials: JP
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Bublat
authors.forename: T
authors.initials: T
authors.lastname: Schulz
authors.forename: C
authors.initials: C
authors.lastname: Voerkel
authors.forename: C
authors.initials: C
authors.lastname: Trantakis
authors.forename: J
authors.initials: J
authors.lastname: Bennek
authors.forename: T
authors.initials: T
authors.lastname: Kahn
authors.forename: H
authors.initials: H
authors.lastname: Busse
mesh_terms: D001842:Bone and Bones / Q000473:pathology; D001921:Brain / Q000473:pathology; D001940:Breast / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D018482:Muscle, Skeletal / Q000473:pathology; D011300:Preoperative Care; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media