Covariance nuclear magnetic resonance spectroscopy.
Covariance nuclear magnetic resonance (NMR) spectroscopy is introduced, which is a new scheme for establishing nuclear spin correlations from NMR experiments. In this method correlated spin dynamics is directly displayed in terms of a covariance matrix of a series of one-dimensional (1D) spectra. In contrast to two-dimensional (2D) Fourier transform NMR, in a covariance spectrum the spectral resolution along the indirect dimension is determined by the favorable spectral resolution obtainable along the detection dimension, thereby reducing the time-consuming sampling requirement along the indirect dimension. The covariance method neither involves a second Fourier transformation nor does it require separate phase correction or apodization along the indirect dimension. The new scheme is demonstrated for cross-relaxation (NOESY) and J-coupling based magnetization transfer (TOCSY) experiments.
Brüschweiler
Rafael
R
Carlson School of Chemistry and Biochemistry, Clark University, Worcester, Massachusetts 01610, USA. brushweiler@nmr.clarku.edu
Zhang
Fengli
F
D005583:Fourier Analysis; D008280:Magnetics; D008956:Models, Chemical; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D012680:Sensitivity and Specificity