Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.
OBJECTIVE
To assess the efficacy of the anti-estrogens tamoxifen and raloxifen in the medical management of persistent pubertal gynecomastia.


METHODS
Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene).


RESULTS
Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients.


CONCLUSIONS
Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.
Lawrence
Sarah E
SE
Department of Pediatrics, University of Ottawa, Ontario, Canada. slawrence@cheo.on.ca
Faught
K Arnold
KA
Vethamuthu
Jennifer
J
Lawson
Margaret L
ML
D000293:Adolescent; D016022:Case-Control Studies; D006177:Gynecomastia / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D017060:Patient Satisfaction; D011627:Puberty / Q000502:physiology*; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D012189:Retrospective Studies; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*; D013629:Tamoxifen / Q000627:therapeutic use*; D016896:Treatment Outcome
D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D020849:Raloxifene Hydrochloride