title: Rupture of a liposomal vesicle.
abstract: We discuss pore dynamics in osmotically stressed vesicles. A set of equations which govern the liposomal size, internal solute concentration, and pore diameter is solved numerically. We find that dependent on the internal solute concentration and vesicle size, liposomes can stay pore free, nucleate a short-lived pore, or nucleate a long-lived pore. The phase diagram of pore stability is constructed, and the different scaling regimes are deduced analytically.
authors.affiliation: Instituto de Física, UFRGS, Caixa Postal 15051, CEP 91501-970, Porto Alegre, RS, Brazil.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Idiart
authors.forename: Yan
authors.initials: Y
authors.lastname: Levin
mesh_terms: D003198:Computer Simulation; D004058:Diffusion; D008081:Liposomes / Q000737:chemistry*; D008560:Membrane Fluidity; D008567:Membranes, Artificial; D008956:Models, Chemical; D008968:Molecular Conformation; D009997:Osmotic Pressure; D010539:Permeability; D044367:Phase Transition; D016062:Porosity; D012996:Solutions; D014867:Water / Q000737:chemistry*
chemical_list: D008081:Liposomes; D008567:Membranes, Artificial; D012996:Solutions; D014867:Water