title: Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives.
abstract: Novel 4"-alkoxy avermectin derivatives were synthesized via rhodium carbenoid mediated O-H insertion reaction and tested for antiparasite activity against Artemia salina and Caenorhabditis elegans.
authors.affiliation: Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Nagai
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sunazuka
authors.forename: Achim
authors.initials: A
authors.lastname: Harder
authors.forename: Andreas
authors.initials: A
authors.lastname: Turberg
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects; D003445:Crustacea / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D007559:Ivermectin; C019264:avermectin