Acetyl-L-carnitine dietary supplementation to old rats increases mitochondrial transcription factor A content in rat hindlimb skeletal muscles.
Acetyl-L-carnitine (ALCAR) fed to old rats has been reported to partially restore mitochondrial function and ambulatory activity. The results of the effect of ALCAR dietary supplementation to 28-month-old rats on mitochondrial transcription factor A (TFAM) content of rat hindlimb skeletal muscles are reported.
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Department of Biochemistry and Molecular Biology, University of Bari, Italy.
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D000108:Acetylcarnitine / Q000494:pharmacology*; D000818:Animals; D004272:DNA, Mitochondrial / Q000378:metabolism; D019587:Dietary Supplements; D006614:Hindlimb / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D051381:Rats; D015398:Signal Transduction; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis*
D004272:DNA, Mitochondrial; C489030:Tfam protein, rat; D014157:Transcription Factors; D000108:Acetylcarnitine