title: A comparative study of age-related brain pathology--are neurodegenerative diseases present in nonhuman animals ?
abstract: Although some aged dogs definitely have dementia-like conditions, they have rather different brain histopathology from that seen in Alzheimer's disease including the shape of senile plaques, severity of neuron loss and absence of neurofibrillary tangles. Aged wild-type mice never show such brain lesions at all. In addition, no cases of Parkinson's disease have been reported in nonhuman animals yet. The reason for this might be non-parallel aging of the whole body and brain. If such nonhuman animals had a longer life span, like humans, typical Alzheimer's and Parkinson's lesions would be formed in the brain. As the rate of deposition of the misfolded proteins causing the lesions might be slow, nonhuman animals normally die before the lesions appear.
authors.affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi Bunkyo-ku Tokyo 113-8657, Japan. anakaya@mail.ecc.u-tokyo.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Kunio
authors.initials: K
authors.lastname: Doi
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000473:pathology*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D000882:Haplorhini; D008136:Longevity; D051379:Mice; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000662:veterinary*; D058225:Plaque, Amyloid / Q000473:pathology; D018419:Primate Diseases / Q000473:pathology*; D011487:Protein Conformation; D012376:Rodent Diseases / Q000473:pathology*