The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids.
The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids is reported. The presence of an N-chloroacetyl group as acyl group in the substrate as well as the use of porcine kidney acylase I as a suitable enzyme component are prerequisites for this resolution process whereby optically active beta-amino acids are formed with high enantioselectivities of >98% ee.
Groger
Harald
H
Degussa AG, Service Center Biocatalysis, P. O. Box 1345, 63403 Hanau, Germany. harald.groeger@degussa.com
Trauthwein
Harald
H
Buchholz
Stefan
S
Drauz
Karlheinz
K
Sacherer
Christiane
C
Godfrin
Sylvie
S
Werner
Helge
H
D000581:Amidohydrolases / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
D000596:Amino Acids; D000581:Amidohydrolases; C019672:aminoacylase I