Gonadotropin treatment of an azoospermic patient with a Y-chromosome microdeletion.
OBJECTIVE
To report on the treatment with recombinant FSH of an azoospermic normogonadotropic patient with a Y-chromosome microdeletion.


METHODS
Case report.


METHODS
An assisted reproduction center.


METHODS
A 32-year-old patient with azoospermia.


METHODS
Histological testicular biopsy, Y-chromosome screening, FSH treatment, and intracytoplasmic sperm injection.


METHODS
Fertilization, embryo development, pregnancy, and delivery.


RESULTS
After 6 months of treatment with gonadotropins, a small number of spermatozoa were found in the patient's ejaculate and used for IVF, resulting in a successful twin pregnancy and the delivery of two healthy girls.


CONCLUSIONS
In this study, treatment with gonadotropins promoted the spermatogenesis process and led to the production of spermatozoa in a normogonadotropic azoospermic patient.
Selman
Helmy A
HA
Istituto Europeo Medicina della Riproduzione Abruzzese, Spatocco Hospital, Chieti, Italy. selmanha@yahoo.com
Cipollone
Giovanni
G
Stuppia
Liborio
L
De Santo
Mariella
M
Sterzik
Karl
K
El-Danasouri
Imam
I
D000328:Adult; D041322:Chromosomes, Human, Y; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D017353:Gene Deletion; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009845:Oligospermia / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy; D011272:Pregnancy, Multiple; D020554:Sperm Injections, Intracytoplasmic; D013091:Spermatogenesis / Q000187:drug effects; D014427:Twins
D006728:Hormones; D005640:Follicle Stimulating Hormone