title: Prognostic importance of renal function in patients with early heart failure and mild left ventricular dysfunction.
abstract: We evaluated the prognostic value of renal function in an initially "untreated" population with mild heart failure and compared the prognosis of this population with a matched controlled population. During a follow-up of 13 years (mean 11.7), 90 patients (56%) died. Mortality was higher compared with a matched controlled population. Multivariate Cox regression analysis demonstrated that beside the well-established risk markers of left ventricular ejection fraction and heart rate, renal function (estimated glomerular filtration rate, hazard ratio 1.16/10 ml/min/1.73 m(2), p = 0.003) was the only additional independent predictor of cardiovascular mortality in patients with early heart failure.
authors.affiliation: Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands. t.d.j.smilde@thorax.azg.nl
authors.forename: Tom D J
authors.initials: TD
authors.lastname: Smilde
authors.forename: Hans L
authors.initials: HL
authors.lastname: Hillege
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Voors
authors.forename: Peter H J
authors.initials: PH
authors.lastname: Dunselman
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Van Veldhuisen
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000401:mortality* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015999:Multivariate Analysis; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D018487:Ventricular Dysfunction, Left / Q000401:mortality* / Q000503:physiopathology