title: Antiprothombin antibodies and the diagnosis of antiphospholipid syndrome.
abstract: The preliminary classification criteria for definite antiphospholipid syndrome (APS) include the presence of anticardiolipin antibodies (aCL) and/or lupus anticoagulant (LA) as laboratory criteria. However, antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies comprising also antibodies against phospholipid-binding proteins or their complexes with phospholipids. Prothrombin is one of the antigen recognized by aPL. In the last decade, there has been increasing interest in antibodies against prothrombin alone and those against phosphatidylserine-prothrombin complex. The latter, phosphatidylserine-dependent antiprothrombin antibodies (aPT), have been closely associated with APS and LA. In this paper, we review the properties of antiprothrombin antibodies.
authors.affiliation: Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Olga
authors.initials: O
authors.lastname: Amengual
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Atsumi
authors.forename: Takao
authors.initials: T
authors.lastname: Koike
mesh_terms: D000818:Animals; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D011516:Prothrombin / Q000276:immunology*; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology
chemical_list: D001323:Autoantibodies; D016682:Lupus Coagulation Inhibitor; D011516:Prothrombin