Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression.
Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.
Mantovani
Alberto
A
Instituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy. mantovani@marionegri.it
Allavena
Paola
P
Sica
Antonio
A
D000951:Antigens, Neoplasm / Q000276:immunology; D015687:Cell Hypoxia; D002465:Cell Movement; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D009369:Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000473:pathology
D000951:Antigens, Neoplasm