title: Periocular cutaneous melanoma arising in a radiotherapy field.
abstract: A 78-year-old woman had a periocular cutaneous melanoma in the radiation field of a meningioma. A medial canthal melanoma arose 32 years after primary radiation for a sphenoid wing meningioma and 22 years after supplemental radiation for meningioma recurrence. Histologic sections taken from skin surrounding the melanoma showed widespread melanocytic atypia and 2 separate foci of melanoma in situ. Cutaneous melanoma can arise in a radiation field after a long latency period and should be considered an uncommon form of secondary malignancy.
authors.affiliation: Department of Ophthalmology, Watson Clinic, LLP, 1600 Lakeland Hills Boulevard, Lakeland, FL 33805, U.S.A. cmargo@watsonclinic.com
authors.forename: Curtis E
authors.initials: CE
authors.lastname: Margo
authors.forename: W Christopher
authors.initials: WC
authors.lastname: Duncan
authors.forename: Alan
authors.initials: A
authors.lastname: Rich
authors.forename: Edward
authors.initials: E
authors.lastname: Garcia
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Stricker
mesh_terms: D000368:Aged; D005143:Eyelids; D005260:Female; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008577:Meningeal Neoplasms / Q000532:radiotherapy*; D008579:Meningioma / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D013100:Sphenoid Bone