title: Inhibitory effect of traditional Turkish folk medicines on aldose reductase (AR) and hematological activity, and on AR inhibitory activity of quercetin-3-O-methyl ether isolated from Cistus laurifolius L.
abstract: The inhibitory effects of 40 extracts prepared from 38 traditional Turkish folk medicines on human aldose reductase (h-AR) and hematological activity were investigated. Seven plants containing 5 species of Cistus genus exhibited a potent inhibition of h-AR. Ferulago amani (root) inhibited the platelet aggregation induced by sodium arachidonate, while C. laurifolius (fruit) was found to possess strong inhibition in the blood coagulation assay. An AcOEt extract derived from the leaf of C. laurifolius was purified to isolate three known flavonoids. The activity of one, quercetin-3-O-methyl ether, was found to be as potent as that of eparlestat, which is known to be a remedy for treating complications associated with diabetes.
authors.affiliation: Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Enomoto
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Okada
authors.forename: Aysegül
authors.initials: A
authors.lastname: Güvenc
authors.forename: Ceyda Sibel
authors.initials: CS
authors.lastname: Erdurak
authors.forename: Maksut
authors.initials: M
authors.lastname: Coşkun
authors.forename: Maskut
authors.initials: M
authors.lastname: Coşkun
authors.forename: Toru
authors.initials: T
authors.lastname: Okuyama
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000925:Anticoagulants / Q000302:isolation & purification / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D029758:Cistus; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D014421:Turkey
chemical_list: D000925:Anticoagulants; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C459210:quercetin 3-O-methyl ether; D011794:Quercetin; D000449:Aldehyde Reductase