title: Radiation-induced genomic instability: a role for secreted soluble factors in communicating the radiation response to non-irradiated cells.
abstract: Radiation induced genomic instability can be described as the increased rate of genomic alterations occurring in the progeny of an irradiated cell. Its manifestations are the dynamic ongoing production of chromosomal rearrangements, mutations, gene amplifications, transformation, microsatellite instability, and/or cell killing. In this prospectus, we present the hypothesis that cellular exposure to ionizing radiation can result in the secretion of soluble factors by irradiated cells and/or their progeny, and that these factors can elicit responses in other cells thereby initiating and perpetuating ongoing genomic instability.
authors.affiliation: Chemistry and Physics of Complex Systems, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: Marianne B
authors.initials: MB
authors.lastname: Sowa Resat
authors.forename: William F
authors.initials: WF
authors.lastname: Morgan
mesh_terms: D024201:Bystander Effect; D002478:Cells, Cultured; D042822:Genomic Instability / Q000528:radiation effects*; D006801:Humans