Leukocyte(s) degranulation: therapeutic targets in [NTP]O and [NDP]O mediated leukocyte(s) degranulation.
Extracellular nucleotide-induced stimulation and activation of peripheral blood leukocyte(s) and subsequent degranulation plays a critical role in immediate type hypersensitivity reaction and other inflammatory diseases. The extracellular nucleotides [NTP]O stimulate a P2Y receptor(s) on human PMN with the pharmacological profile similar to that of the P2Y2 receptor. Whereas, [NTP]O and [NDP]O, bind to P2Y2 and P2Y1 receptors on mononuclear leukocytes. Based on a recent proposal on the molecular mechanism of [NTP]O- and [NDP]O-induced leukocyte(s) degranulation, a scheme indicating the therapeutic targets with potential avenues for attenuating leukocyte(s) degranulation is suggested.
Kannan
Subburaj
S
Department of Physiology, School of Medicine, Temple University, Philadelphia, PA 19140, USA. sukannan@utmb.edu
D015550:Cell Degranulation / Q000502:physiology*; D015195:Drug Design; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D009504:Neutrophils / Q000502:physiology*; D009711:Nucleotides / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000378:metabolism
D009711:Nucleotides; D018048:Receptors, Purinergic P2