title: The production and localization of GTP-bound ran in mitotic mammalian tissue culture cells.
abstract: The RanGTPase system has multiple functions in both interphase and mitosis. Extensive studies of Ran-driven nucleocytoplasmic transport have contributed significantly toward our understanding of how RanGTP is produced, hydrolyzed, and localized in interphase. However, there is still a lack of understanding about how this system operates in mitosis. Recent advances have begun to shed light on how RanGTP is produced and localized in mitotic mammalian cells.
authors.affiliation: Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA.
authors.forename: Hoi-Yeung
authors.initials: HY
authors.lastname: Li
authors.forename: Yixian
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000737:chemistry; D006160:Guanosine Triphosphate / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D020931:ran GTP-Binding Protein / Q000378:metabolism*
chemical_list: D006160:Guanosine Triphosphate; D020931:ran GTP-Binding Protein