title: Unbuckling lipodystrophy from insulin resistance and hypertension.
abstract: Lipodystrophy and insulin resistance are the core features of human PPARgamma deficiency states. Metabolic complications in PPARgamma deficiency, such as hypertension, have been considered to be secondary to insulin resistance. However, a new mouse model that expresses the analog of a human PPARG mutation displays minimal lipodystrophy and insulin resistance but rather severe hypertension. Furthermore, the mutant protein appears to directly modulate the renin-angiotensin system in adipose tissue, providing evidence of the pleiotropic effects of PPARgamma.
authors.affiliation: Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 406-100 Perth Drive, London, Ontario N6A 5K8, Canada. hegele@robarts.ca
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hegele
authors.forename: Todd
authors.initials: T
authors.lastname: Leff
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008060:Lipodystrophy / Q000378:metabolism*; D051379:Mice; D018160:Receptors, Cytoplasmic and Nuclear / Q000172:deficiency / Q000235:genetics; D012084:Renin-Angiotensin System / Q000502:physiology; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors