title: Glucocorticoid receptor and Beta-adrenoceptor expression in epididymal adipose tissue from stressed rats.
abstract: Adipocytes isolated from epididymal adipose tissue of foot-shock stressed rats are supersensitive to isoprenaline and subsensitive to norepinephrine. These alterations are probably mediated by a stress-induced increase in plasma corticosterone levels. We investigated whether foot-shock stress modifies the expression of glucocorticoid receptors (GRs) and beta-adrenergic protein receptors (beta-ARs) in epididymal adipose tissue from rats submitted to one daily foot-shock session on three consecutive days. This stress protocol caused decreases in GR, beta(1)-AR, and beta(3)-AR protein levels, but caused an increase in beta(2)-AR. These results confirm and support previous functional studies. The alterations in protein expression may be modulated by the high corticosterone levels that downregulate the glucocorticoid receptor.
authors.affiliation: Laboratório do Estudo do Estresse (LABEEST), Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, CEP: 13089-970, Campinas, SP, Brasil. rspabrat@unicamp.br
authors.forename: Elisangela
authors.initials: E
authors.lastname: Farias-Silva
authors.forename: Iraídes Nunes
authors.initials: IN
authors.lastname: dos Santos
authors.forename: Maria Esméria
authors.initials: ME
authors.lastname: Corezola do Amaral
authors.forename: Dora Maria
authors.initials: DM
authors.lastname: Grassi-Kassisse
authors.forename: Regina Celia
authors.initials: RC
authors.lastname: Spadari-Bratfisch
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D004822:Epididymis / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D011943:Receptors, Adrenergic, beta; D011965:Receptors, Glucocorticoid