Chlamydia--host cell interactions: recent advances on bacterial entry and intracellular development.
Bacteria of the Chlamydiales order are very successful intracellular organisms that grow in human and animal cells, and even in amoebae. They fulfill several essential functions to enter their host cells, establish an intracellular environment favorable for their multiplication and exit the host cell. They multiply in a unique organelle called the inclusion, which is isolated from the endocytic but not the exocytic pathway. A combination of host cell factors and of proteins secreted by the bacteria, from within the inclusion, contribute to the establishment and development of this inclusion. Here we review recent data on the entry mechanisms and maturation of the inclusion.
Dautry-Varsat
Alice
A
Unité de Biologie des Interactions Cellulaires, Institut Pasteur, URA CNRS 2582, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. adautry@pasteur.fr
Balañá
María Eugenia
ME
Wyplosz
Benjamin
B
D000199:Actins / Q000378:metabolism; D018829:Adhesins, Bacterial / Q000378:metabolism; D000818:Animals; D002689:Chlamydia / Q000378:metabolism* / Q000472:pathogenicity; D002690:Chlamydia Infections / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism; D021962:Membrane Microdomains / Q000378:metabolism; D015398:Signal Transduction
D000199:Actins; D018829:Adhesins, Bacterial