[Usefulness of serum markers in renal cell carcinoma].
OBJECTIVE
To select a group of useful serum markers in renal cell carcinoma (RCC) with investigational purpose in future.


METHODS
Periodic determination in serum of 21 RCC patients of the following markers: EGR, RPC, hemogram and leucocyte differential count (LDC), standard biochemist parameters, beta-2 microglobuline, CEA, CA 12.5, CA 50, CA 15.3, ferritin, interleukin-6, serum interleukin-2 receptor, TNF-alpha and TPSA.


RESULTS
Different elements within the LDC had relations with the presence of symptoms/signs, tumour size, pathological stage and disease progression. There was a significant increase of beta-2 microglobuline and sIL-2 receptor when disease progressed, as well as a similar statistical trend with RPC and alkaline phosphatases. Beta-2 microglobuline and sIL-2 receptor also decreased after treatment of the disease progression.


CONCLUSIONS
We will keep analysing hemogram, LDC and standard byochemics, RPC, ferritin, beta-2 microglobuline and sIL-2 receptor only with investigational purposes, obviating the determination of the rest of the tested markers.
Rubio Briones
J
J
Servicio Urología, Instituto Valenciano de Oncología, Valencia.
Iborra Juan
I
I
Aznar
E
E
Climent
M A
MA
López-Guerrero
J A
JA
Maíquez
J
J
Monrós Lliso
J L
JL
Casanova Ramón-Borja
J
J
Dumont Martínez
R
R
Ricós Torrent
J V
JV
Solsona Narbón
E
E
D014408:Biomarkers, Tumor / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood*
D014408:Biomarkers, Tumor