Stereoselective iodocyclization of 3-acylamino-2-methylene alkanoates: synthesis of analogues of N-benzoyl-syn-phenylisoserine.
[reaction: see text] A convenient approach to racemic analogues of N-benzoyl-syn-phenylisoserine was realized via the stereoselective iodocyclization of amides obtained from Baylis-Hillman adducts.
Galeazzi
Roberta
R
Dipartimento di Scienze dei Materiali e della Terra, Università Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, Italy.
Martelli
Gianluca
G
Mobbili
Giovanna
G
Orena
Mario
M
Rinaldi
Samuele
S
D000473:Alkanes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis*; D003500:Cyclization; D007455:Iodine / Q000737:chemistry; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry; D012694:Serine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000473:Alkanes; D001555:Benzene Derivatives; C495936:N-benzoyl-syn-phenylisoserine; D012694:Serine; D007455:Iodine; D017239:Paclitaxel