title: Adrenal myelolipoma. 6 cases and a review of the literature.
abstract: Adrenal myelolipoma is an uncommon, benign and hormonally inactive tumor. Most lesions are asymptomatic and usually are discovered incidentally at autopsy studies. Authors report on 6 patients (5 women, 1 man) with adrenal myelolipomas (5 right, 1 left), analyze their morphological findings and association with an adrenal hormonal overproduction. Five of the patients underwent surgery because of tumor size, in 3 of them histological evaluation confirmed myelolipoma and in 2 cases an adrenocortical adenoma with foci of myelolipoma. All the patients were asymptomatic and in 4 cases hormonal overproduction was not found. One female patient has oveproduction of dehydroepiandrosteron-sulphate (DHEAS) indicating a 3beta hydroxylase deficiency in this tumor and 1 patient has primary aldosteronism with a histological finding of an association of adrenocortical adenoma with foci of myelolipoma. Neither Cushings syndrome nor congenital adrenal hyperplasia were present in our group of patients.
authors.affiliation: Department of Internal Medicine, Faculty Hospital Kosice, 04011, Slovak Republic. wagnerh2002@yahoo.com
authors.forename: H
authors.initials: H
authors.lastname: Wagnerová
authors.forename: I
authors.initials: I
authors.lastname: Lazúrová
authors.forename: J
authors.initials: J
authors.lastname: Bober
authors.forename: L
authors.initials: L
authors.lastname: Sokol
authors.forename: M
authors.initials: M
authors.lastname: Zachar
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000473:pathology*; D000311:Adrenal Glands / Q000473:pathology; D000368:Aged; D000728:Androgens / Q000378:metabolism; D003480:Cushing Syndrome / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000378:metabolism; D018209:Myelolipoma / Q000175:diagnosis / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D000728:Androgens; D006899:Mixed Function Oxygenases