A diversity-oriented strategy for the construction of tetrasubstituted pyrroles via coupled domino processes.
A new microwave-assisted rearrangement of 1,3-oxazolidines scaffolds is the basis for a new, metal-free, direct, and modular construction of tetrasubstituted pyrroles from terminal-conjugated alkynes, aldehydes, and primary amines. This new reaction manifold entails two linked domino processes in a one-pot manner with both atom- and bond-efficiency and under very simple and environment-friendly experimental conditions.
Tejedor
David
D
Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Avenida Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Canary Islands, Spain.
González-Cruz
David
D
García-Tellado
Fernando
F
Marrero-Tellado
José Juan
JJ
Rodríguez
Matías López
ML