Exploring effects of different antioxidants on dexamethasone-induced lipid peroxidation using common laboratory markers.
As a part of our ongoing effort to explore drug-induced lipid peroxidation in relation to drug-induced toxicity, our recent observations on lipid peroxidation induction potential of dexamethasone, a commonly used glucocorticoid compound in inflammatory and allergic conditions, has been presented considering lipid peroxidation a possible mediator of toxicity. An attempt was made to see the suppressive actions of some conventional antioxidant compounds, viz, ascorbic acid, alpha-tocopherol and probucol on dexamethasone-induced lipid peroxidation. It was found from the study that dexamethasone increased malondialdehyde content vis-a-vas decreased the level of reduced glutathione significantly in the liver homogenate. This suggests that dexamethasone caused a significant extent of lipid peroxidation which may be related to the toxic potential of the drug. It was further found all of the above antioxidants could suppress dexamethasone-induced lipid peroxidation to the significant extent.
De
Kakali
K
Division of Medicinal & Pharmaceutical Chemistry Department of Pharmaceutical Technology Jadavpur University, Calcutta.
Roy
K
K
Saha
A
A
Sengupta
C
C
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers; D003907:Dexamethasone / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D005978:Glutathione / Q000737:chemistry; D006041:Goats; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008315:Malondialdehyde / Q000737:chemistry; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D015415:Biomarkers; D016166:Free Radical Scavengers; D005938:Glucocorticoids; D014810:Vitamin E; D008315:Malondialdehyde; D003907:Dexamethasone; D005978:Glutathione