'Dipeptidyl peptidase-IV activity and/or structure homologs' (DASH) in growth-modulated glioma cell lines.
Dipeptidyl peptidase-IV has been demonstrated to play a role in cancer biology by many authors. Since then, additional proteins possessing similar enzymatic activity have been described and their role in cancerogenesis has been hypothesized. To assess the complexity of these 'Dipeptidyl peptidase-IV activity and/or structure homologs' (DASH) in glioma cells, we have studied their presence in cell lines of different degree of transformation. Our results provide evidence of cell line-specific expression and distribution of dipeptidyl peptidase-IV enzyme activity-bearing molecules and their dynamics associated with cell growth conditions. The biologic outcome of DASH pattern of composition probably depends on the regulatory peptides/DASH substrates in the cellular environment.
Sedo
Aleksi
A
Joint Laboratory of Cancer Cell Biology of the 1st Faculty of Medicine, Charles University Prague and the Institute of Physiology, Academy of Sciences of Czech Republic, Prague, CZ-12853, Czech Republic. Aleksi@mbox.cesnet.cz
Busek
Petr
P
Scholzová
Eva
E
Malík
Radek
R
Vlasicová
Kveta
K
Janácková
Sona
S
Mares
Vladislav
V
D000818:Animals; D002455:Cell Division / Q000502:physiology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry / Q000378:metabolism; D005910:Glioma / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D051379:Mice
D018819:Dipeptidyl Peptidase 4