title: Auditory evoked responses in postmenopausal women on hormone replacement therapy.
abstract: The effect of hormone replacement therapy (HRT) was studied in 32 postmenopausal women on their auditory Evoked Potentials i.e. auditory brainstem response (ABR), Middle latency response (MLR) & slow vertex response (SVR). Recordings were done on computerized evoked potential recorder using 10/20 system of electrode placement and standard click stimuli. A significant improvement in neural transmission was observed as was evidenced by decrease in the ABR wave latencies I, III, IV & V and interpeak latency III-V and I-V after 6 months of HRT. A similar significant decrease was observed in MLR wave latencies of Po, Na & Pa. The SVR wave latencies although found to be decreased after HRT, could not reach the level of statistical significance. There was a significant inverse correlation obtained between latencies of wave I in ABR, Po in MLR and serum estradiol. The results indicate the effect of sex hormone in improving transmission in auditory pathway from periphery through brainstem, thalamus upto cortex. However slow vertex responses indicate that auditory association areas are not much affected. This might have bearing on improvement of neuropsychological functions in postmenopausal women on HRT.
authors.affiliation: Department of Physiology, University College of Medical Sciences & GTB Hospital, Dilshad Garden, Delhi 110 095. farahphysio@hotmail.com
authors.forename: Farah
authors.initials: F
authors.lastname: Khaliq
authors.forename: O P
authors.initials: OP
authors.lastname: Tandon
authors.forename: Neerja
authors.initials: N
authors.lastname: Goel
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D004958:Estradiol / Q000097:blood; D015914:Estrogen Replacement Therapy / Q000379:methods / Q000706:statistics & numerical data*; D004967:Estrogens / Q000494:pharmacology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D017698:Postmenopause / Q000097:blood / Q000187:drug effects* / Q000502:physiology; D011374:Progesterone / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012044:Regression Analysis
chemical_list: D004967:Estrogens; D011374:Progesterone; D004958:Estradiol