Hypoxic vasorelaxation: Ca2+-dependent and Ca2+-independent mechanisms.
The mechanisms of oxygen sensing in vascular smooth muscle have been studied extensively in a variety of tissue types and the results of these studies indicate that the mechanism of hypoxia-induced vasodilation probably involves several mechanisms that combined to assure the appropriate response. After a short discussion of the regulatory mechanisms for smooth muscle contractility, we present the evidence indicating that hypoxic vasorelaxation involves both Ca2+-dependent and Ca2+-independent mechanisms. More recent experiments using proteomic approaches in organ cultures of porcine coronary artery reveal important changes evoked by hypoxia in both Ca2+-dependent and Ca2+-independent pathways.
Thorne
George D
GD
Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ishida
Yukisato
Y
Paul
Richard J
RJ
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015687:Cell Hypoxia / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D012433:Ryanodine / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D012433:Ryanodine; D002118:Calcium