title: Reactive airways dysfunction syndrome caused by bromochlorodifluoromethane from fire extinguishers.
abstract: Although the neurological and cardiovascular effects of Freons have been extensively described, the respiratory effects have been less well documented. We report four cases of occupational asthma following accidental exposure to bromochlorodifluoromethane (Halon 1211) due to release of the contents of a fire extinguisher. All subjects developed an irritative reaction of the upper airways and lower respiratory symptoms immediately after exposure. Non-specific bronchial hyperreactivity was present for at least two months in all subjects and was still present more than two years after exposure in one case. The diagnosis of reactive airways dysfunction syndrome can be adopted in at least three of these four cases.
authors.affiliation: Unité de Pathologie Professionnelle, Service de Pneumologie et Pathologie Professionnelle, CHI Créteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Matrat
authors.forename: M F
authors.initials: MF
authors.lastname: Laurence
authors.forename: Y
authors.initials: Y
authors.lastname: Iwatsubo
authors.forename: C
authors.initials: C
authors.lastname: Hubert
authors.forename: N
authors.initials: N
authors.lastname: Joly
authors.forename: K
authors.initials: K
authors.lastname: Legrand-Cattan
authors.forename: J P
authors.initials: JP
authors.lastname: L'Huillier
authors.forename: C
authors.initials: C
authors.lastname: Villemain
authors.forename: J C
authors.initials: JC
authors.lastname: Pairon
mesh_terms: D000328:Adult; D000337:Aerospace Medicine; D001249:Asthma / Q000139:chemically induced*; D064228:Bromochlorofluorocarbons; D016535:Bronchial Hyperreactivity / Q000139:chemically induced; D005617:Chlorofluorocarbons, Methane / Q000506:poisoning*; D005260:Female; D005388:Fire Extinguishing Systems; D005411:Flame Retardants / Q000506:poisoning*; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects; D013577:Syndrome
chemical_list: D064228:Bromochlorofluorocarbons; D005617:Chlorofluorocarbons, Methane; D005411:Flame Retardants; C037990:bromochlorodifluoromethane