Expression of growth differentiation factor-5 in the developing and adult rat brain.
Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.
O'Keeffe
Gerard W
GW
Department of Neuroscience/Anatomy, Biosciences Research Institute, National University of Ireland Cork, College Road, Cork, Ireland.
Hanke
Michael
M
Pohl
Jens
J
Sullivan
Aideen M
AM
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D001921:Brain / Q000166:cytology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D002478:Cells, Cultured; D004298:Dopamine / Q000378:metabolism; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D055428:Growth Differentiation Factor 5; D015151:Immunoblotting / Q000379:methods; D051381:Rats
D019485:Bone Morphogenetic Proteins; D055428:Growth Differentiation Factor 5; D004298:Dopamine