title: [Bronchioloalveolar carcinoma of the lung associated with a highly positive pANCA-titer and clinical signs of microscopic polyangiitis].
abstract: Autoimmune paraneoplastic processes are investigated in detail concerning the Lambert-Eaton-Myasthenic-Syndrome for bronchial carcinomas. For the cutaneous leukocytoclastic vasculitis as a non-ANCA-associated vasculitis the paraneoplastic genesis is described. Litttle is known about ANCA-associated vasculitis as a paraneoplastic autoimmune phenomenon. We present the case of a 62 year old woman referred to our hospital presenting air-space shadows mainly in both upper lobes, skin rash with petechial bleeding and a highly positive pANCA-titer. A bronchioloalveolar carcinoma was diagnosed by surgical biopsy. The patient developed renal failure postsurgically and died a few weeks after the diagnosis was established. This is the 5 (th) case in literature of the temporal concurrence of a bronchial carcinoma and an ANCA-associated vasculitis. So far only 24 cases of a solid tumor occuring simultaneously with an ANCA-positive vasculitis are reported in literature.
authors.affiliation: II. Medizinische Klinik Schwerpunkt Pneumologie, Johann-Wolfgang-Goethe-Universität Frankfurt. watz.henrik@web.de
authors.forename: H
authors.initials: H
authors.lastname: Watz
authors.forename: P
authors.initials: P
authors.lastname: Hammerl
authors.forename: C
authors.initials: C
authors.lastname: Matter
authors.forename: M
authors.initials: M
authors.lastname: Degen
authors.forename: F
authors.initials: F
authors.lastname: Heimann
authors.forename: H
authors.initials: H
authors.lastname: Heitmann
authors.forename: L
authors.initials: L
authors.lastname: Ermert
authors.forename: T O
authors.initials: TO
authors.lastname: Wagner
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D014657:Vasculitis
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic