title: Nitrous oxide increases the incidence of bowel distension in patients undergoing elective colon resection.
abstract: BACKGROUND
  Nitrous oxide rapidly inflates gas-filled spaces such as the intestines; but whether the resulting bowel distension is clinically important remains unclear. We therefore tested the hypothesis that nitrous oxide produces clinically important bowel distension.
  
  
  METHODS
  Patients scheduled for colon resection were anesthetized with isoflurane and 35% oxygen and randomly assigned to 65% nitrous oxide (n = 175) or 65% nitrogen in air (n = 169). At the end of surgery, blinded surgeons rated the degree of bowel distension as none, mild, moderate, or severe. Patients reported pain, and nausea and vomiting (PONV) 2 h after surgery. Data are reported as means (SD). P < 0.05 was statistically significant.
  
  
  RESULTS
  Morphometric and demographic data were similar in the groups. The duration of surgery was 3.0 (1.2) h in the nitrous oxide group and 3.4 (1.5) h in the air group (P = 0.017). Postoperative self-reported pain scores (visual analog scale, 0-100 mm) were greater in the nitrous oxide group (43 [30] mm) than in the air group (35 [31] mm, P = 0.018). Although the incidence of PONV was similar in the groups, VAS scores for nausea were significantly greater in the nitrous oxide group (P = 0.040). Moderate-to-severe bowel distension was observed in 23% of nitrous oxide patients, but in only 9% of patients in the air group (P < 0.001). The number-needed-to-harm for moderate or severe bowel distension from nitrous oxide was thus seven.
  
  
  CONCLUSIONS
  Our results suggest that avoiding nitrous oxide administration during prolonged bowel operations will minimize bowel distension and possibly reduce postoperative pain related to it.
authors.affiliation: Outcomes Research Institute, Department of Anesthesiology, University of Louisville, KY, USA.
authors.forename: O
authors.initials: O
authors.lastname: Akca
authors.forename: R
authors.initials: R
authors.lastname: Lenhardt
authors.forename: E
authors.initials: E
authors.lastname: Fleischmann
authors.forename: T
authors.initials: T
authors.lastname: Treschan
authors.forename: R
authors.initials: R
authors.lastname: Greif
authors.forename: R
authors.initials: R
authors.lastname: Fleischhackl
authors.forename: O
authors.initials: O
authors.lastname: Kimberger
authors.forename: A
authors.initials: A
authors.lastname: Kurz
authors.forename: D I
authors.initials: DI
authors.lastname: Sessler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003106:Colon / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D007410:Intestinal Diseases / Q000139:chemically induced / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000009:adverse effects*; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology; D011312:Pressure
chemical_list: D009609:Nitrous Oxide