title: Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction.
abstract: The aim of this study was to investigate in patients with neurogenic orthostatic hypotension the mechanism and usefulness of abdominal compression to increase standing blood pressure. In three protocols, 23 patients underwent abdominal compression. Protocol 1 evaluated in a 40-60 degrees head-up-tilt position, the effect of abdominal compression on caval vein and femoral diameter, arterial blood pressure and hemodynamics. Protocol 2 documented the relationship between the level of compression and the arterial pressure response. Protocol 3 investigated the ability to maintain standing blood pressure by an elastic binder. During head-up-tilt, compression (40 mm Hg) resulted in a reduction in diameter of the caval vein (mean -2.6mm, range -1.4 to 0.6), without a change in femoral vein diameter. Stroke volume increased by 14 % (range -1 to 23) and blood pressure (systolic/diastolic) by 30/14 mmHg (range 7/2 to 69/36), both p < 0.05; 40 mmHg compression was associated with a higher pressure response than 20 mmHg (mean 18/8 mmHg, range 6/2 to 43/20 vs. mean 9/4 mmHg, range -1/0 to 18/8, p < 0.05). Elastic abdominal binding increased standing blood pressure with 15/6 mmHg (range -3/3 to 36/14, p < 0.05). We conclude that in patients with neurogenic orthostatic hypotension, abdominal compression increases standing blood pressure to a varying degree by increasing stroke volume.
authors.affiliation: Dept. of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Adrianus A J
authors.initials: AA
authors.lastname: Smit
authors.forename: Wouter
authors.initials: W
authors.lastname: Wieling
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujimura
authors.forename: Jong C
authors.initials: JC
authors.lastname: Denq
authors.forename: Tonette L
authors.initials: TL
authors.lastname: Opfer-Gehrking
authors.forename: Mohammed
authors.initials: M
authors.lastname: Akarriou
authors.forename: John M
authors.initials: JM
authors.lastname: Karemaker
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Low
mesh_terms: D000005:Abdomen / Q000502:physiology*; D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000628:therapy*; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D003929:Diabetic Neuropathies / Q000503:physiopathology; D005260:Female; D005676:Gravity Suits; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012146:Rest / Q000502:physiology; D016683:Supine Position / Q000502:physiology; D014680:Veins / Q000502:physiology