Outcome of simultaneous kidney pancreas transplantation: a single center analysis.
The aim of this study was to evaluate the outcome of simultaneous kidney pancreas transplantation (SKPT) by various surgical techniques. The 161 patients submitted to SKPT underwent the following: 36 pancreas with duct occlusion (from 1985 to 1989), 75 with whole pancreas with bladder diversion (from 1990 to 1998), and 50 whole pancreas with enteric diversion (40 with systemic and 10 with portal drainage) (from 1999 to September 2002). A positive effect on patient survival was evident using enteric diversion versus the duct occlusion group (P = .005), and versus the bladder diversion group (.035), and on pancreas graft survival in the enteric diversion versus the duct occlusion group (P < .028). These improvements may be due to refined donor and patient selection criteria, surgical technique, and immunosuppression.
Orsenigo
E
E
Department of Surgery, IRCCS-San Raffaele, Milano, Italy.
Florina
P
P
Cristallo
M
M
Socci
C
C
La Rocca
E
E
Invernizzi
L
L
Secchi
A
A
Di Carlo
V
V
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery*; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods / Q000401:mortality / Q000502:physiology*; D016035:Pancreas Transplantation / Q000379:methods / Q000401:mortality / Q000502:physiology*; D011183:Postoperative Complications / Q000145:classification / Q000453:epidemiology; D017582:Renal Replacement Therapy; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014511:Uremia / Q000601:surgery*; D014552:Urinary Tract Infections / Q000453:epidemiology