Glyco-dependent nuclear import of glycoproteins, glycoplexes and glycosylated plasmids.
This short review deals with some properties of nuclear sugar-binding proteins also called nuclear lectins, the sugar-dependent nuclear import of neoglycoproteins and the attempts of using this pathway to enhance the nuclear import of plasmids in order to hopefully increase the expression of transferred genes.
Monsigny
Michel
M
Glycobiologie, Vectorologie et Trafic Intracellulaire, Centre de Biophysique Moléculaire, Centre National de la Recherche Scientifique, 1 rue Charles-Sadron, F-45071 Orléans Cedex 2, France. monsigny@cnrs-orleans.fr
Rondanino
Christine
C
Duverger
Eric
E
Fajac
Isabelle
I
Roche
Annie-Claude
AC
D000818:Animals; D001692:Biological Transport; D002467:Cell Nucleus / Q000378:metabolism*; D015316:Genetic Therapy; D006023:Glycoproteins / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D008362:Mannosides; D008845:Microinjections; D010957:Plasmids / Q000378:metabolism*; D011761:Pyrrolidonecarboxylic Acid
D006023:Glycoproteins; D037102:Lectins; D008362:Mannosides; D011761:Pyrrolidonecarboxylic Acid