Preparations and spectroscopic studies of organotin complexes of diclofenac.
The reactions of the potent and widely used anti-inflammatory drug diclofenac, HL, with diorganotin(IV) oxides were studied. The dimeric tetraorganodistannoxane complexes [Me(2)LSnOSnLMe(2)](2), [Bu(2)LSnOSnLBu(2)](2), [Ph(2)LSnOSnLPh(2)](2) and the dibutyltin complex [Bu(2)SnL(2)], have been prepared and structurally characterized in the solid state by means of vibrational and 119Sn Mössbauer spectroscopy. Determination of lattice dynamics by temperature-dependent 119Sn Mössbauer spectroscopy. From the variable-temperature Mössbauer effect, the Debye temperature was determined. The complexes have been characterized in solution by NMR (1H and 13C) spectroscopy. Vibrational, Mössbauer, and NMR data are discussed in terms of the proposed structures.
Kourkoumelis
Nikolaos
N
Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45100 Ioannina, Greece.
Demertzis
Mavroudis A
MA
Kovala-Demertzi
Dimitra
D
Koutsodimou
Aglaia
A
Moukarika
Alice
A
D002247:Carbon Isotopes; D004008:Diclofenac / Q000138:chemical synthesis / Q000737:chemistry*; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D002247:Carbon Isotopes; D009947:Organotin Compounds; D004008:Diclofenac; D006859:Hydrogen