Cytoplasmic dysmorphisms in metaphase II chimpanzee oocytes.
Prior to fertilization by intracytoplasmic sperm injection (ICSI), cytoplasmic organization was evaluated in metaphase II chimpanzee oocytes obtained from stimulated ovaries. The findings demonstrate a high frequency of anomalies that are remarkably similar to the types of cytoplasmic dysmorphisms reported for human oocytes used in IVF. Similar to the human, the occurrence of these anomalies was oocyte- and animal-specific and associated with reduced competence as indicated by embryo development in vitro to the blastocyst stage.
Suzuki
Kimie
K
Kumamoto Primates Research Park, Sanwa Kagaku Kenkyusho Co., Ltd, 990 Nishikuroiwa, Ohtao, Misumi-Cho, Uto-Gun, Kumamoto 869-3201, Japan. ki_suzuki@skk-net.com
Yoshimoto
Nobuhiko
N
Shimoda
Kohji
K
Sakamoto
Wataru
W
Ide
Yukie
Y
Kaneko
Takehito
T
Nakashima
Tatsuyuki
T
Hayasaka
Ikuo
I
Nakagata
Naomi
N
D000818:Animals; D001755:Blastocyst / Q000502:physiology; D003593:Cytoplasm / Q000235:genetics / Q000473:pathology*; D047108:Embryonic Development; D005260:Female; D008677:Metaphase; D009865:Oocytes / Q000473:pathology* / Q000502:physiology; D002679:Pan troglodytes; D020554:Sperm Injections, Intracytoplasmic