Antioxidant effect of curcumin in selenium induced cataract of Wistar rats.
Wistar rat pups treated with curcumin, a natural constituent of Curcuma longa before being administered with selenium showed no opacities in the lens. The lipid peroxidation, xanthine oxidase enzyme levels in the lenses of curcumin and selenium co-treated animals were significantly less when compared to selenium treated animals. The superoxidase dismutase and catalase enzyme activities of curcumin and selenium co-treated animal lenses showed an enhancement. Curcumin co-treatment seems to prevent oxidative damage and found to delay the development of cataract.
Padmaja
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S
Physiology Division, Department of Zoology, University College of Science, Osmania University, Hyderabad 500 007, India.
Raju
T N
TN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D002386:Cataract / Q000139:chemically induced / Q000188:drug therapy*; D003474:Curcumin / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015227:Lipid Peroxidation; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D013997:Time Factors; D014969:Xanthine Oxidase / Q000378:metabolism
D000975:Antioxidants; D004791:Enzyme Inhibitors; D002374:Catalase; D014969:Xanthine Oxidase; D012643:Selenium; D003474:Curcumin