New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization.
The functionalization of an oligonucleotide by flavin and deazaflavin derivatives allowed an amperometric determination of the hybridization process through the disappearance of the electroactivity of the free oligonucleotide and the appearance of a new electrochemical signal characteristic of the resulting duplex.
Cosnier
Serge
S
Laboratoire d'Electrochimie Organique et de Photochimie Rédox UMR 5630 CNRS Institut de Chimie Moléculaire de Grenoble FR CNRS 2607, Université Joseph Fourier, BP 53, 38041 Grenoble 9, France. serge.cosnier@ujf-grenoble.fr
Gondran
Chantal
C
Dueymes
Cécile
C
Simon
Philippe
P
Fontecave
Marc
M
Décout
Jean-Luc
JL
D001483:Base Sequence; D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D004563:Electrochemistry / Q000379:methods*; D005415:Flavins / Q000737:chemistry*; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*
D015342:DNA Probes; D005415:Flavins; D009838:Oligodeoxyribonucleotides; D004247:DNA