Intermediate reactive oxygen and nitrogen from macrophages induced by Brazilian lichens.
The activity of ten compounds isolated from Brazilian lichen over the release of hydrogen peroxide and nitric oxide was evaluated in the culture of peritoneal macrophage cells from mice. Salazinic, secalonic A and fumarprotocetraric acids were the compounds that induced the greatest release of H2O2, whereas 12R-usnic and diffractaic acids induced the release of NO. These results indicate that lichen products have potential immunological modulating activities.
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Departamento de Química Orgânica, Instituto de Química, UNESP, Araraquara, São Paulo, Brazil. loursant@iq.unesp.br
Honda
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Carlos
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Vilegas
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D000818:Animals; D001685:Biological Factors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D006861:Hydrogen Peroxide / Q000378:metabolism; D008011:Lichens; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D001685:Biological Factors; D010936:Plant Extracts; D009569:Nitric Oxide; D006861:Hydrogen Peroxide