title: [Interferon-alpha and ribavirin therapy on chronic hepatitis C virus infection: the experience of Rio Grande do Sul State Health Department, Brazil].
abstract: BACKGROUND
  Chronic infection by hepatitis C virus is an important public health issue.
  
  
  OBJECTIVE
  To assess the effectiveness of a combination therapy with interferon-alpha plus ribavirin and to identify predictive factors of response in adult patients with chronic hepatitis C in a public drug supply program.
  
  
  METHODS
  A retrospective study of consecutive records of 400 patients with chronic hepatitis C treated with interferon-a plus ribavirin therapy, as part of a health program conducted by the Department of Health of the State of Rio Grande do Sul, Porto Alegre, RS, southern Brazil, between 1999 and 2000, was carried out.
  
  
  RESULTS
  Sex distribution was similar, and the average age was 46.5 +/- 10.3 years. Response at the end of the treatment was observed in 49% of patients, and sustained response was observed in 32% of them. Sustained response was significantly higher in females and in patients infected by genotypes other than 1. We did not observe significant differences in terms of age or histological stage and activity score.
  
  
  CONCLUSIONS
  In adult patients with chronic hepatitis C, combination therapy with interferon-alpha plus ribavirin was effective in one third of patients. Higher rates of response were observed in women and in patients infected by genotypes other than 1.
authors.affiliation: Disciplina de Gastroenterologia da Fundação Faculdade Federal de Ciências Médicas de Porto Alegre.
authors.forename: Alexandro Vaesken
authors.initials: AV
authors.lastname: Alves
authors.forename: Andrea Prates da Cunha
authors.initials: AP
authors.lastname: de Azevedo
authors.forename: Chistiano
authors.initials: C
authors.lastname: Perin
authors.forename: Gabriel Zatti
authors.initials: GZ
authors.lastname: Ramos
authors.forename: Ajacio Bandeira de Mello
authors.initials: AB
authors.lastname: Brandão
authors.forename: Angelo Alves
authors.initials: AA
authors.lastname: de Mattos
authors.forename: Paulo Roberto Leiria
authors.initials: PR
authors.lastname: de Almeida
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005838:Genotype; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin