title: Left ventricular hypertrophy is associated with cerebral microbleeds in hypertensive patients.
abstract: BACKGROUND
  Cerebral microbleeds (CMBs) are indicative of hemorrhage-prone microangiopathy and known to be closely associated with chronic hypertension. However, no studies have been undertaken on the association between left ventricular (LV) hypertrophy and the severity of CMB.
  
  
  METHODS
  One hundred two consecutive stroke patients with hypertension were examined. CMBs were counted using T2*-weighted gradient echo MRI data. With use of ordinal logistic regression analysis, the associations between LV mass index and other vascular risk factors and CMBs were analyzed.
  
  
  RESULTS
  Hypertensive patients with CMBs showed a higher LV mass index than patients without. The grades of LV mass index were significantly correlated with the grades of CMB in the whole brain (p = 0.02), in the central gray matter (p < 0.01), and in the infratentorial area (p < 0.01), but not with those in the subcortical white matter. Ordinal regression analysis revealed that the LV mass index was independently associated with increased CMB severity (p = 0.01), regionally in the central gray matter (p < 0.01) and in the infratentorial area (p < 0.01), but not in the subcortical white matter (p = 0.63). After excluding patients with cerebral amyloid angiopathy, the association between the LV mass index and the CMB severity in the subcortical white matter became significant (p < 0.01).
  
  
  CONCLUSIONS
  There is a close relationship between CMBs and LV hypertrophy in hypertensive patients with stroke. Thus, CMBs should be understood as one type of cerebral target organ damage by chronic hypertension.
authors.affiliation: Department of Neurology, School of Public Health, SNUMRC and Clinical Research Institute, Seoul National University Hospital, Republic of Korea.
authors.forename: S-H
authors.initials: SH
authors.lastname: Lee
authors.forename: J-M
authors.initials: JM
authors.lastname: Park
authors.forename: S-J
authors.initials: SJ
authors.lastname: Kwon
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: Y-H
authors.initials: YH
authors.lastname: Kim
authors.forename: J-K
authors.initials: JK
authors.lastname: Roh
authors.forename: B-W
authors.initials: BW
authors.lastname: Yoon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000000981:diagnostic imaging; D007723:Korea / Q000453:epidemiology; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014463:Ultrasonography; D020257:Ventricular Remodeling