title: The moderating effects of tension-reduction alcohol outcome expectancies on placebo responding in individuals with social phobia.
abstract: We conjectured that individual differences in tension-reduction alcohol outcome expectancies (TR-AOEs) could produce widely varying responses to manipulations in alcohol-placebo studies and tested this idea by having individuals with social phobia give speeches in front of a group. One speech occurred before and one after participants consumed either a placebo beverage or a control beverage (i.e., a nonalcoholic drink described as containing no alcohol). Study results indicate that the placebo manipulation reduced cognitive and affective symptoms of anxiety to a greater extent for males with high TR-AOEs than for males with low TR-AOEs. This pattern was not found for women in the placebo group or for individuals in the control group. These findings demonstrate a moderating effect of TR-AOEs on the association between the consumption of a placebo beverage and response to an anxiety challenge and highlight the importance of accounting for gender and outcome expectancies when evaluating psychoactive substances.
authors.affiliation: Department of Psychiatry, University of Minnesota, Fairview-Riverside Hospital, F-282-2A West, 2450 Riverside Avenue, Minneapolis 55455, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Abrams
authors.forename: Matt G
authors.initials: MG
authors.lastname: Kushner
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology*; D000704:Analysis of Variance; D001290:Attitude; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000517:prevention & control / Q000523:psychology*; D015990:Placebo Effect; D011594:Psychometrics; D012737:Sex Factors; D013060:Speech