title: Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats.
abstract: Since a very complicated technique is necessary to measure cerebral blood flow (CBF) with [14C]iodoantipyrine in small animals, a practical and easy method is needed. In this paper, the differential uptake ratio (DUR) at 5 min after injection of N-isopropyl-p-[125I]iodoamphetamine (IMP) was estimated as an index of CBF in normal rats and compared with the quantitative CBF value measured using [15O]H2O and dynamic PET scan. A good correlation between the two values was obtained. The results indicate that DUR of [125I]IMP at 5 min after injection in rats is a useful and practical indicator of CBF since neither arterial blood sampling nor metabolite correction is necessary.
authors.affiliation: Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Temma
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Magata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mukai
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Kitano
authors.forename: Junji
authors.initials: J
authors.lastname: Konishi
authors.forename: Hideo
authors.initials: H
authors.lastname: Saji
mesh_terms: D000465:Algorithms; D000818:Animals; D001345:Autoradiography; D001834:Body Water; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D020367:Iofetamine; D008297:Male; D008863:Microspheres; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019275:Radiopharmaceuticals; D020367:Iofetamine