title: Skin Donors Positive for HBV Core Antibodies - to Bank or Not to Bank? An Overview from a Regional Tissue Bank.
abstract: A prompt transplantation of skin allografts on patients with severe, large body area burns is a preferred treatment, but depends on a suitable supply of tissue donors. Limiting factors include donors' identification, families consent, and following the standards - exclusion due to assessed transmissible diseases. To increase the current rate of skin donations to our regional skin bank, we reviewed the data of all potential organ donors, identified at Soroka University Medical Center from October 1997 to December 2000 and evaluated the causes for exclusion, especially due to HBV serological profile. 114/168 (67.9%) patients did not meet the indicated standards for organ donation, among which 20/114 patients (17.5%) positive for anti-HBc (anti-HBc(+)). 54/168 persons were declared brain dead, with consents obtained from 21 families. To discuss the intriguing approval of skin from potential donors with anti-HBc(+) serology, the literature was reviewed, specifically - the reported outcomes of organ transplants from anti-HBc(+) donors, updates of HBV and skin, available tests, and finally a look for a safe commendable algorithm. The results suggested that HBV might be replicating in the skin, but proven communication of HBV has not been reported following grafting skin from anti-HBc(+) donors. Unlike other procured organs and tissues, grafted banked skin is a temporary cover, storable up to six years, under appropriate conditions. Hence, banking of skin from anti-HBc(+) donors might be considered for future grafting of patients with identical serological profiles, presumably immune to a subsequent HBV infection, until a further re-evaluation of the standards. This procedure is anticipated to increase the potential of organ and tissue donations, specifically skin.
authors.affiliation: Skin Bank and Investigative Dermatology Laboratory, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84101, Israel; Department of Microbiology and Immunology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84101, Israel; Author for correspondence (Tel./Fax: 972-8-6400934; e-mail: grossman@bgumail.bgu.ac.il)
authors.forename: Nili
authors.initials: N
authors.lastname: Grossman
authors.forename: Edna
authors.initials: E
authors.lastname: Arbel