title: Expressional changes of neuropeptide Y and cholecystokinin in the arcuate and paraventricular nuclei after capsaicin administration.
abstract: Despite its toxicity, a great deal of attention has been paid to the anorexic effect of capsaicin in the treatment of obesity-related neurotransmitters/neuromodulators. To determine if capsaicin has any effects on the orexigenic or anorexigenic peptides, the neuropeptide Y (NPY)- and cholecystokinin (CCK)-immunoreactivities were demonstrated in the rat hypothalamus by immunohistochemistry after capsaicin administration. There was a significantly lower concentration of NPY immunopositive cells in the arcuate and paraventricular nuclei of the capsaicin treated rats. In contrast, the CCK expressions level was higher in the paraventricular nucleus of the capsaicin treated rats than in the control rats. These results suggest that capsaicin influence neuropeptides such as orexigenic NPY and anorexigenic CCK related to control food intake.
authors.affiliation: Department of Anatomy and Cell Biology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea.
authors.forename: In Se
authors.initials: IS
authors.lastname: Lee
authors.forename: Young Sam
authors.initials: YS
authors.lastname: Nam
authors.forename: Choong Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Chung
authors.forename: Yeo Sung
authors.initials: YS
authors.lastname: Yoon
authors.forename: Jin Sang
authors.initials: JS
authors.lastname: Kim
authors.forename: Seong Joon
authors.initials: SJ
authors.lastname: Yi
authors.forename: Tongkun
authors.initials: T
authors.lastname: Pai
authors.forename: Heungshik S
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000737:chemistry / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology*; D002766:Cholecystokinin / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry; D009478:Neuropeptide Y / Q000032:analysis*; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry* / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009478:Neuropeptide Y; D002766:Cholecystokinin; D002211:Capsaicin