Firing rates and dynamic correlated activities of ganglion cells both contribute to retinal information processing.
In the present study, the electrical activities of paired retinal ganglion cells, under full field light stimuli with a variety of chromatic configurations, were recorded from a small functioning piece of retina using multi-electrode array (MEA). Neurons that had increased firings at light-ON and -OFF transients and did not show color-opponent properties were investigated. Single neuronal analysis showed that firing rate of each individual neuron was dependent on the intensity of illumination. Multi-unit analyses revealed that adjacent neurons often fired in synchrony in response to light stimulation. However, in some cases, the strength of correlation between the paired neurons was higher when the retina was exposed to red or green light, and the correlation was attenuated when yellow or white light was given. This seems to suggest that the ensemble activity of non-color-opponent ganglion cells might partly participate in color-information processing, with the red- and green-pathway inputs influencing each other. Such arrangement reflects principle of parsimony: the firing rates of single neuron represent the luminance intensity, and the correlated activities may tell the brain about the color information.
Chen
Ai-Hua
AH
Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, PR China.
Zhou
Yi
Y
Gong
Hai-Qing
HQ
Liang
Pei-Ji
PJ
D000200:Action Potentials / Q000502:physiology* / Q000528:radiation effects; D000818:Animals; D000831:Animals, Newborn; D002645:Chickens; D003116:Color; D004307:Dose-Response Relationship, Radiation; D066298:In Vitro Techniques; D008027:Light; D016571:Neural Networks, Computer; D017711:Nonlinear Dynamics; D010775:Photic Stimulation / Q000379:methods; D012160:Retina / Q000166:cytology*; D012165:Retinal Ganglion Cells / Q000502:physiology* / Q000528:radiation effects; D013223:Statistics as Topic