Splenopancreatic field abnormality is not unique to trisomy 13.
Splenopancreatic fusion is an uncommon finding, usually only seen as part of the splenopancreatic field abnormality associated with trisomy 13. It may present itself either as ectopic splenic tissue in the cauda pancreatis, as ectopic pancreatic tissue in the spleen or accessory spleen, or as fusion of the cauda pancreatis and splenic hilum. In this study, we report four unrelated congenital anomaly cases presenting trisomy 21, osteocraniostenosis syndrome, isolated congenital heart defect, and oligohydramnios sequence due to prune belly syndrome, in which fusion was observed. This demonstrates that, although it may be more common in trisomy 13, this phenomenon should not be interpreted as pathognomonic to that syndrome.
Peres
Luiz Cesar
LC
Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, SP 14049-900, Brazil. lcperes@fmrp.usp.br
Barbosa
Gustavo Henrique T de Sales
GH
Careta
Renata Scarpat
RS
Nassif
Cristiane Miziara
CM
de Pina-Neto
João Monteiro
JM
Giuliani
Liane R
LR
Martinhago
Ciro Dresch
CD
Gomy
Israel
I
D002882:Chromosomes, Human, Pair 13; D004314:Down Syndrome; D005260:Female; D005313:Fetal Death; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010179:Pancreas / Q000002:abnormalities* / Q000473:pathology; D013154:Spleen / Q000002:abnormalities* / Q000473:pathology; D014314:Trisomy