Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis.
New data support the importance of the innate immune response in the resolution or progression of pulmonary fibrosis. The presence of CXC chemokine receptor 3-expressing cells, specifically pulmonary NK cells, is necessary to produce IFN-gamma. This is critical in the polarization of the immune response to injury toward a favorable Th1 response and resolution. In contrast, a Th2 response is associated with progressive fibrosis.
Strieter
Robert M
RM
Department of Medicine, Division of Pulmonary and Critical Care Medicine, The David Geffen School of Medicine at the University of California, Los Angeles 90095-1786, USA. rstrieter@mednet.ucla.edu
Keane
Michael P
MP
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D011658:Pulmonary Fibrosis / Q000276:immunology*; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
C515187:CXCR3 protein, human; C515188:Cxcr3 protein, mouse; D016207:Cytokines; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine