Trisomy 1 in a case of a missed abortion.
Most chromosomal trisomies lead to miscarriages. In all trisomies, trisomy 1 is the most rare case. We herein present a patient who demonstrated a gestational sac and a yolk sac on transvaginal ultrasound. However, at 53 days of gestation, the pregnancy was lost with a diagnosis of a blighted ovum. A D&C was recommended and performed. A cytogenetic analysis from chorionic villi demonstrated a 47,XX,+1 chromosome complement in all 100 cells. Regarding full trisomy 1, there has only been one case report of a preembryo and two case reports in a clinically recognized pregnancy to date.
Banzai
Michio
M
Department of Obstetrics and Gynecology, Saiseikai Yamagata Hospital, 79-1 Okimachi, Yamagata 990-8545, Japan. banzai@macbase.or.jp.
Sato
Satoshi
S
Department of Obstetrics and Gynecology, Saiseikai Yamagata Hospital, 79-1 Okimachi, Yamagata 990-8545, Japan.
Matsuda
Hideo
H
Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Japan.
Kanasugi
Hiroshi
H
Department of Obstetrics and Gynecology, Saiseikai Yamagata Hospital, 79-1 Okimachi, Yamagata 990-8545, Japan.
D000030:Abortion, Missed / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014314:Trisomy