title: Aminotriazine 5-HT7 antagonists.
abstract: The present studies have identified a series of aminotriazines as novel 5-HT(7) receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT(7) receptor and do not bind to either the 5-HT(2C) or 5-HT(6) receptors. These compounds produce no agonist effects by themselves, and shift the dose-response curve of 5-CT to the right in the manner of an antagonist.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA. mattsonr@bms.com
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Mattson
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Denhart
authors.forename: John D
authors.initials: JD
authors.lastname: Catt
authors.forename: Michael F
authors.initials: MF
authors.lastname: Dee
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Deskus
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Ditta
authors.forename: James
authors.initials: J
authors.lastname: Epperson
authors.forename: H
authors.initials: H
authors.lastname: Dalton King
authors.forename: Aiming
authors.initials: A
authors.lastname: Gao
authors.forename: Michael A
authors.initials: MA
authors.lastname: Poss
authors.forename: Ashok
authors.initials: A
authors.lastname: Purandare
authors.forename: David
authors.initials: D
authors.lastname: Tortolani
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Suresh
authors.initials: S
authors.lastname: Yeola
authors.forename: Jane
authors.initials: J
authors.lastname: Palmer
authors.forename: John
authors.initials: J
authors.lastname: Torrente
authors.forename: Arlene
authors.initials: A
authors.lastname: Stark
authors.forename: Graham
authors.initials: G
authors.lastname: Johnson
mesh_terms: D004305:Dose-Response Relationship, Drug; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014227:Triazines / Q000494:pharmacology*
chemical_list: D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014227:Triazines; C104425:serotonin 7 receptor