Acquired fanconi syndrome induced by mixed Chinese herbs presenting as proximal muscle weakness.
We report a rare case with acquired Fanconi syndrome caused by mixed Chinese herbs, initially presenting as waddling gait and lower limb muscle atrophy. From a series of investigations, proximal renal tubule injury with functional defects and Chinese herb nephropathy were discovered. Hypophosphatemic osteomalacia and type II muscle fiber atrophy shown in muscle biopsy of left quadriceps may be associated with the sequelae of ingestion of mixed crude Chinese herbs. Aggressive and early alkali treatment with supplementation of phosphate and Vitamin D restored the patient's metabolic and musculoskeletal abnormalities.
Chan
Jenq-Shyong
JS
Department of Internal Medicine, Armed Forces Taoyuan General Hospital, Taiwan, ROC.
Yang
An-Han
AH
Kao
Ko-Pei
KP
Tarng
Der-Cherng
DC
D000328:Adult; D001706:Biopsy; D005198:Fanconi Syndrome / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology; D008297:Male; D018908:Muscle Weakness / Q000139:chemically induced*; D010946:Plants, Medicinal / Q000009:adverse effects*