[Effects of reproductive hormones on spermatogenesis].
Spermatogenesis, a continuous course of cell proliferation and differentiation, depends on reproductive hormones. FSH and LH-induced T are the main hormones regulating spermatogensis. Intratesticular T is one of the key factors in maintaining spermatogenesis, while FSH is just as important for origination and maintenance of normal spermatogenesis. Sertoli cells are the pivot of hormonal regulation. Interestingly, these reproductive hormones also regulate sperm cell apoptosis spermatogenesis. Further studies on the hormonal regulation of spermatogenesis provide a base for the development of safe and recoverable contraceptives for males.
Cui
Yugui
Y
Key Laboratory, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China. cuiygui@njmu.edu.cn
Chen
Ziqing
Z
Sha
Jiahao
J
D000728:Androgens / Q000502:physiology*; D017209:Apoptosis; D003267:Contraception; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D006801:Humans; D007986:Luteinizing Hormone / Q000502:physiology*; D008297:Male; D013091:Spermatogenesis
D000728:Androgens; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone