title: Schatzki ring and Barrett's esophagus: do they occur together?
abstract: Our purpose was to determine the prevalence of Barrett's esophagus in the presence of Schatzki ring. We performed a retrospective case-control study with an endoscopic database. Barrett's esophagus was present in 3 of 409 (0.73%) patients with Schatzki ring and in 16 of 888 (1.80%) patients without Schatzki ring. Short segment Barrett's esophagus was present in 3 cases and 10 controls. Long segment Barrett's esophagus was present in no cases and six controls. Logistic regression models adjusting for the presence of a hiatal hernia revealed a significant decrease in the odds of Barrett's esophagus in cases compared to controls (OR, 0.24; 95% CI, 0.07-0.87; P = 0.029). Barrett's esophagus is less prevalent in patients with Schatzki ring compared to patients without Schatzki ring. Long segment Barrett's esophagus was not observed in patients with Schatzki ring. A responsible protective effect or mutually exclusive pathophysiology should be considered.
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Marcia C
authors.initials: MC
authors.lastname: Mitre
authors.forename: David A
authors.initials: DA
authors.lastname: Katzka
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Brensinger
authors.forename: James D
authors.initials: JD
authors.lastname: Lewis
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Mitre
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Ginsberg
mesh_terms: D001471:Barrett Esophagus / Q000453:epidemiology* / Q000209:etiology; D004935:Esophageal Diseases / Q000175:diagnosis* / Q000209:etiology; D004945:Esophagoscopy; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies