Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas.
Unsaturated fatty acid amides, 9(Z)-octadecenamide (2) and 9(Z),12(Z)-octadecadienamide (4) as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) were isolated from the ethyl acetate extracts of the insect, Mylabris phalerate Pallas, and elucidated by their spectroscopic data analysis. Compounds 2 and 4 inhibited rat liver microsomal ACAT, hACAT-1, and hACAT-2 with IC(50) values of 170, 85, and 63 microM for 2 and of 151, 53, and 45 microM for 4, respectively.
Xu
Ming-Zhe
MZ
Insect Resources Laboratory, Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Daejeon 305-333, Republic of Korea.
Lee
Woo Song
WS
Kim
Mi Jeong
MJ
Park
Doo-Sang
DS
Yu
Hana
H
Tian
Guan-Rong
GR
Jeong
Tae-Sook
TS
Park
Ho-Yong
HY
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013712:Tenebrio / Q000737:chemistry*
D000577:Amides; D005227:Fatty Acids; D002785:Sterol O-Acyltransferase