Molecular epidemiology of canid rabies in Sudan: evidence for a common origin of rabies with Ethiopia.
Rabies is an endemic zoonosis in Sudan with the principal reservoir species being the domestic dog. A panel of rabies virus isolates from dogs in Sudan have been used to establish a molecular phylogeny based on a partial sequence of the viral nucleoprotein. These isolates were then compared to those from countries bordering Sudan in north-east Africa. The Sudanese viruses form a tight cluster of isolates with a single outlier. When compared to other African viruses, the Sudanese isolates cluster most closely with isolates from Ethiopia to the East suggesting a common origin for rabies in both countries which supports historical records of the movement of rabies into Sudan. The Sudanese group of viruses belong to the Africa 1a group of viruses that are present throughout much of north Africa.
Johnson
N
N
Rabies Research and Diagnostic Group, WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, Veterinary Laboratories Agency, Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK.
McElhinney
L M
LM
Ali
Y H
YH
Saeed
Intisar K
IK
Fooks
A R
AR
D000818:Animals; D000829:Animals, Domestic; D004197:Disease Reservoirs / Q000662:veterinary; D004283:Dog Diseases / Q000453:epidemiology* / Q000821:virology; D004285:Dogs; D005002:Ethiopia / Q000453:epidemiology; D017720:Molecular Epidemiology; D009698:Nucleoproteins; D010802:Phylogeny; D011818:Rabies / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000145:classification / Q000235:genetics*; D013397:Sudan / Q000453:epidemiology
D009698:Nucleoproteins