Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice.
The effect of corosolic acid (CA) on blood glucose was studied in KK-Ay mice, an animal model of type 2 diabetes. CA (10 mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4 h after single oral administration when compared with the control group. However, CA did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density microsomal membrane to plasma membrane was significantly increased in the orally CA-treated mice when compared with that of the controls (p<0.05). These results suggest that the hypoglycemic effect of CA is derived, at least in part, from an increase in GLUT4 translocation in muscle. Therefore, it may be that CA has beneficial effects on hyperglycemia in type 2 diabetes.
Miura
Toshihiro
T
Department of Clinical Nutrition, Suzuka University Medical Science, Mie, Japan. miura@suzuka-u.ac.jp
Itoh
Yasushi
Y
Kaneko
Tetsuo
T
Ueda
Naoya
N
Ishida
Torao
T
Fukushima
Mitsuo
M
Matsuyama
Futoshi
F
Seino
Yutaka
Y
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000235:genetics*; D004195:Disease Models, Animal; D051275:Glucose Transporter Type 4; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D009004:Monosaccharide Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics* / Q000378:metabolism*; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use
D001786:Blood Glucose; D051275:Glucose Transporter Type 4; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495693:Slc2a4 protein, mouse; D014315:Triterpenes; C113861:corosolic acid