Effects of epsilon-aminocaproiloaminoacids on the amidolytic activity of tissue plasminogen activator, urokinase and kallikrein.
Effect of three epsilon-aminocaproylaminoacids with a significant antifibrinolytic activity on amidolytic activity of tissue plasminogen activator (t-PA), urokinase and kallikrein was examined. epsilon-Aminocaproyl-S-benzyl)-L-cysteine and epsilon-aminocaproyl-L-norleucine were weak inhibitors of kallikrein. Weak activation of t-PA activity was observed at high concentration of the tested compounds. Only one of the examined dipeptides was a weak inhibitor of amidolytic activity of urokinase.
Midura-Nowaczek
Krystyna
K
Department of Organic Chemistry, Medical University of Bialystok, I Kilifiskiego Str., 15-089 Bialystok, Poland.
Bruzgo
Irena
I
Roszkowska-Jakimiec
Wiesława
W
Markowska
Agnieszka
A
D000577:Amides / Q000737:chemistry*; D000614:Aminocaproates; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000933:Antifibrinolytic Agents / Q000494:pharmacology*; D007610:Kallikreins / Q000737:chemistry*; D011994:Recombinant Proteins / Q000737:chemistry; D010959:Tissue Plasminogen Activator / Q000737:chemistry*; D014568:Urokinase-Type Plasminogen Activator / Q000737:chemistry*
D000577:Amides; D000614:Aminocaproates; D000933:Antifibrinolytic Agents; D011994:Recombinant Proteins; D007610:Kallikreins; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator; D015119:Aminocaproic Acid