A new experimental design for screening Chinese medicine formula.
In this paper, an appropriate scale screening for traditional Chinese medicine formula was developed in according to verified pharmacological experiments with uniform optimized experimental design and orthogonal optimized experimental design. Meanwhile, a most appropriate match of prescription dosage for curing vascular disease was got, which was based on NO value of pharmacodynamics experimental data and the endothelial cells configuration which would changed in a degree when damaged by hydration diamine. The appropriate scale of the formula was Ginkgo extraction: substance A:B:C = 100:20:50:0.01. This formula was more optimized and effective than other formula compared by pharmacological and validated experiments.
Chun-Hong
Tang
T
Key Laboratory of Biomechanics and Tissue Engineering under the State Ministry of Education, Bioengineering College for Chongqing University, Chongqing 400044, PR China.
Bo-Chu
Wang
W
Qi
Chen
C
Li
Zhou
Z
Shao-Xi
Cai
C
D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects; D020441:Ginkgo biloba / Q000737:chemistry; D008516:Medicine, Chinese Traditional; D009566:Nitrates / Q000032:analysis / Q000378:metabolism; D009573:Nitrites / Q000032:analysis / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D015203:Reproducibility of Results; D012107:Research Design; D014652:Vascular Diseases / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D009566:Nitrates; D009573:Nitrites; D010936:Plant Extracts