title: [Study of thromboxane A2 antagonist reduction in the treatment of patients with perennial allergic rhinitis].
abstract: We investigated whether or not we could reduce the medication for patients with perennial allergic rhinitis after improvement of the nasal symptoms. We administered the thromboxane A2 receptor antagonist Ramatroban, which also improves non-specific hypersensitivity, for 4 weeks and then reduced the dose to half for 4 weeks and investigated the severity of general symptoms and each nasal symptom (sneeze, rhinorrhea, and congestion). There was a significant improvement in the severity of general symptoms and each nasal symptom for the first 4 weeks (p<0.01), which was maintained for 4 weeks after reduction of the dose (n=14). There was no difference in the severity of symptoms between the reduced dosage (n=14) and the maintained dosage (n=15) groups. We also investigated the level of eosinophilia in nasal smears before and after the treatment (n=14) and showed that the level was significantly (p<0.01) reduced after the start of treatment. In conclusion, it was noted that we could reduce the dose of Ramatroban after the improvement of nasal symptoms on patients with perennial allergic rhinitis.
authors.affiliation: Department of Otolaryngology, Hakodate Municipal Hospital. narito@hospital.hakodate.hokkaido.jp
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Narita
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shirasaki
authors.forename: Junichi
authors.initials: J
authors.lastname: Itoh
authors.forename: Kazutoyo
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Himi
mesh_terms: D000328:Adult; D002227:Carbazoles / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000037:antagonists & inhibitors*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D013449:Sulfonamides / Q000008:administration & dosage*
chemical_list: D002227:Carbazoles; D044244:Receptors, Thromboxane A2, Prostaglandin H2; D013449:Sulfonamides; C063119:ramatroban