title: Is the degree of sensitivity to nondepolarizing muscle relaxants related to requirements for postoperative ventilation in patients with myasthenia gravis?
abstract: The purpose of this study was to examine whether the degree of sensitivity to nondepolarizing muscle relaxants is related to the requirement for postoperative ventilatory support in patients with myasthenia gravis. Thirty-six patients with myasthenia gravis undergoing trans-sternal thymectomy were monitored by electromyography in order to assess the neuromuscular response to vecuronium. After calibration to 100% of baseline electromyographic response values using an EMG monitor, incremental doses of 5, 10 and 20 microg/kg of vecuronium were administrated to produce 95% neuromuscular blockade and to obtain a cumulative dose-response curve for each patient. A univariable logistic regression with odds ratio was used to examine the predictive variables of prolonged postoperative ventilation. Depending on their postoperative ventilatory needs, patients were divided into an early extubation group and a prolonged ventilatory group. There were no significant differences between the two groups in terms of vecuronium ED95 (prolonged ventilation group: 23.2 +/- 18 microg/kg; early extubation group: 23.2 +/- 18 microg/kg P=0.129) and vecuronium requirement to maintain less than 25% neuromuscular blockade (prolonged ventilation group: 24 +/- 1.7 mg/kg; early extubation group: 3.8 +/- 4.5 mg/kg P=0.249). There were, however, significant differences in the incidence of a history of previous respiratory crises and the presence of bulbar palsy between the early extubation and prolonged ventilation groups. History of previous respiratory crisis (odds ratio (OR), 3.5; 95% confidence interval (CI), 1.0-13; P=0.03) and presence of bulbar palsy (OR, 3.7; 95%CI, 0.9-15; P=0.049) were associated with the need for prolonged postoperative ventilation. However, we failed to demonstrate that the degree of sensitivity to nondepolarizing muscle relaxants was related to an increased requirement for postoperative ventilation in patients with myasthenia gravis.
authors.affiliation: Department of Intensive Care, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kadoi
authors.forename: H
authors.initials: H
authors.lastname: Hinohara
authors.forename: F
authors.initials: F
authors.lastname: Kunimoto
authors.forename: A
authors.initials: A
authors.lastname: Niijima
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: F
authors.initials: F
authors.lastname: Goto
mesh_terms: D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000378:metabolism / Q000601:surgery*; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D011182:Postoperative Care; D011950:Receptors, Cholinergic / Q000032:analysis; D012121:Respiration, Artificial; D013934:Thymectomy; D014673:Vecuronium Bromide / Q000008:administration & dosage*
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D011950:Receptors, Cholinergic; D014673:Vecuronium Bromide