title: Alverine citrate induced acute hepatitis.
abstract: Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests on biochemical screening. Other etiologies of hepatitis were appropriately ruled out and elevated enzymes were ascribed to alverine citrate treatment. Although alverine citrate hepatotoxicity was related to an immune mechanism in the first case, several features such as absence of predictable dose-dependent toxicity of alverine citrate in a previous study and absence of hypersensitivity manifestations in our patient are suggestive of a metabolic type of idiosyncratic toxicity.
authors.affiliation: Kavaklik mah, Ahmet Apaydln cad, Sultan Apartment, No 39/7, Sahinbey 27060, Gaziantep, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Arhan
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Koklu
authors.forename: Aydln-S
authors.initials: AS
authors.lastname: Koksal
authors.forename: Omer-F
authors.initials: OF
authors.lastname: Yolcu
authors.forename: Senem
authors.initials: S
authors.lastname: Koruk
authors.forename: Irfan
authors.initials: I
authors.lastname: Koruk
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Kayacetin
mesh_terms: D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D011437:Propylamines / Q000009:adverse effects*
chemical_list: D011437:Propylamines; C010846:alverine