title: Surface alignment of an elastic body using a multiresolution wavelet representation.
abstract: An algorithm for nonlinear registration of an elastic body is developed. Surfaces (outlines) of known anatomic structures are used to align all other (internal) points. The deformation field is represented with a multiresolution wavelet expansion and is modeled by the partial differential equations of linear elasticity. A hierarchical approach that reduces algorithm complexity is adopted. The performance of the algorithm is evaluated by two-dimensional alignment of sections from mouse brains located in the olfactory bulbs. The registration algorithm was guided by manually delineated contours of a subset of brain structures and validated based on another subset of brain structures. The wavelet alignment algorithm produced a twofold to fivefold improvement in accuracy over an affine (linear) alignment algorithm.
authors.affiliation: Computer Vision Laboratory for Vertebrate Brain Mapping, Department of Neurobiology and Anatomy, Drexel College of Medicine, Drexel University, Philadelphia, PA 19129-1096, USA.
authors.forename: Smadar
authors.initials: S
authors.lastname: Gefen
authors.forename: Oleh
authors.initials: O
authors.lastname: Tretiak
authors.forename: Louise
authors.initials: L
authors.lastname: Bertrand
authors.forename: Glenn D
authors.initials: GD
authors.lastname: Rosen
authors.forename: Jonathan
authors.initials: J
authors.lastname: Nissanov
mesh_terms: D000465:Algorithms; D019412:Anatomy, Cross-Sectional / Q000379:methods*; D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology; D004548:Elasticity; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique