title: Childhood sickle cell crises: clinical severity, inflammatory markers and the role of interleukin-8.
abstract: There is emerging consensus that a pro-inflammatory condition contributes to the vaso-occlusive complications of sickle cell disease (SCD). We evaluated the potential value of inflammatory mediators as early markers of severity of painful vaso-occlusive crises (VOC) in SCD. We assayed the plasma levels of cytokines, soluble vascular cell adhesion molecule-1, acute phase proteins, secretory phospholipase and standard hematologic indices.
authors.forename: Maryse
authors.initials: M
authors.lastname: Etienne-Julan
authors.forename: Marie-Sylvaine
authors.initials: MS
authors.lastname: Belloy
authors.forename: Monique
authors.initials: M
authors.lastname: Decastel
authors.forename: Samuel
authors.initials: S
authors.lastname: Dougaparsad
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ravion
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Hardy-Dessources
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood*; D016207:Cytokines / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood* / Q000502:physiology; D012720:Severity of Illness Index; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D016209:Interleukin-8; D019010:Vascular Cell Adhesion Molecule-1