title: MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.
abstract: Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.
authors.affiliation: Dipartimento di Ematologia ed Oncologia Pediatrica, Istituto Giannina Gaslini, L.go G. Gaslini 5, 16148 Genova, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Morerio
authors.forename: Annamaria
authors.initials: A
authors.lastname: Rapella
authors.forename: Cristina
authors.initials: C
authors.lastname: Rosanda
authors.forename: Edoardo
authors.initials: E
authors.lastname: Lanino
authors.forename: Luca
authors.initials: L
authors.lastname: Lo Nigro
authors.forename: Andrea
authors.initials: A
authors.lastname: Di Cataldo
authors.forename: Emanuela
authors.initials: E
authors.lastname: Maserati
authors.forename: Francesco
authors.initials: F
authors.lastname: Pasquali
authors.forename: Claudio
authors.initials: C
authors.lastname: Panarello
mesh_terms: D019457:Chromosome Breakage; D007446:Chromosome Inversion; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D015321:Gene Rearrangement; D018740:Genetic Heterogeneity; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C470550:MLL-AF10 fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein