title: [Study on the effect of weitongning on epidermal growth factor and nitric oxide contents in tissue of stomach of rats with gastric ulcer].
abstract: OBJECTIVE
  To study the therapeutic mechanism of weitongning (WTN) in treating peptic ulcer.
  
  
  METHODS
  Rat model of chronic gastric ulcer induced by glacial acetic acid was used to observe the effect of WTN on the curative quality, thickness of regenerated mucous membrane, epidermal growth factor (EGF) and nitric oxide (NO) contents in scar tissue around the gastric ulcer.
  
  
  RESULTS
  The thickness of regenerated mucous membrane, EGF and NO contents in peri-ulcer scar tissue were higher in the model rats after WTN treatment than that in the untreated model rats (P<0.01 or P<0.05).
  
  
  CONCLUSIONS
  WTN could elevate the quality of ulcer curing, to raise the EGF and NO contents in peri-ulcer scar tissue might be one of its mechanisms for preventing relapse of peptic ulcer.
authors.affiliation: Affiliated Hospital of Medical School, Hubei College of Nationalities, Wuhan (445000). zbwgmy@sina.com
authors.forename: Xue-gang
authors.initials: XG
authors.lastname: Zheng
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Yun-chun
authors.initials: YC
authors.lastname: Huang
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000378:metabolism*
chemical_list: D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D004815:Epidermal Growth Factor