title: The PIK3CA gene is mutated with high frequency in human breast cancers.
abstract: The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation. It has recently been reported that somatic mutations within the PI3K subunit p110alpha (PIK3CA) are present in human colorectal and other cancers. Here we show that thirteen of fifty-three breast cancers (25%) contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain. These results demonstrate that PIK3CA is the most mutated oncogene in breast cancer and support a role for PIK3CA in epithelial carcinogenesis.
authors.affiliation: The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Department of Oncology, Baltimore, Maryland 21231, USA. kbachman1@yahoo.com
authors.forename: Kurtis E
authors.initials: KE
authors.lastname: Bachman
authors.forename: Pedram
authors.initials: P
authors.lastname: Argani
authors.forename: Yardena
authors.initials: Y
authors.lastname: Samuels
authors.forename: Natalie
authors.initials: N
authors.lastname: Silliman
authors.forename: Janine
authors.initials: J
authors.lastname: Ptak
authors.forename: Steve
authors.initials: S
authors.lastname: Szabo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Konishi
authors.forename: Bedri
authors.initials: B
authors.lastname: Karakas
authors.forename: Brian G
authors.initials: BG
authors.lastname: Blair
authors.forename: Clarence
authors.initials: C
authors.lastname: Lin
authors.forename: Brock A
authors.initials: BA
authors.lastname: Peters
authors.forename: Victor E
authors.initials: VE
authors.lastname: Velculescu
authors.forename: Ben Ho
authors.initials: BH
authors.lastname: Park
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D058534:Class I Phosphatidylinositol 3-Kinases; D005091:Exons / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D020125:Mutation, Missense; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics* / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D019869:Phosphatidylinositol 3-Kinases; D058534:Class I Phosphatidylinositol 3-Kinases; C484760:PIK3CA protein, human