title: Bilateral central retinal vein occlusion associated with multiple myeloma.
abstract: OBJECTIVE
  To report a case of simultaneous bilateral central retinal vein occlusion (CRVO) associated with multiple myeloma.
  
  
  METHODS
  A 65-year-old woman had sudden, painless loss of vision in both eyes for 20 days. Ophthalmologic examination revealed bilateral CRVO. Appropriate medical workup was conducted, and multiple myeloma was diagnosed as the underlying cause.
  
  
  RESULTS
  Clinical support and chemotherapy effectively controlled paraprotein production, leading to improvement of both systemic and ocular alterations.
  
  
  CONCLUSIONS
  Many conditions have been noted to be associated with CRVO. Based on a Medline search, this is the first report of simultaneous bilateral CRVO as the first manifestation of multiple myeloma, illustrating the need for a primary care ophthalmologist to be involved in the basic assessment for associated underlying diseases in retinal disorders.
authors.affiliation: Department of Ophthalmology, Instituto da Visão - IPEPO, São Paulo, Brazil. aggio@oftalmo.epm.br
authors.forename: Fabio B
authors.initials: FB
authors.lastname: Aggio
authors.forename: Angelino J
authors.initials: AJ
authors.lastname: Cariello
authors.forename: Manuella S S
authors.initials: MS
authors.lastname: Almeida
authors.forename: Celso A
authors.initials: CA
authors.lastname: Rodrigues
authors.forename: Nilva S B
authors.initials: NS
authors.lastname: De Moraes
authors.forename: Gisele W B
authors.initials: GW
authors.lastname: Colleoni
authors.forename: Michel E
authors.initials: ME
authors.lastname: Farah
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D019572:Retinal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012170:Retinal Vein Occlusion / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D041623:Tomography, Optical Coherence; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin