title: Association of a sex-related difference of Strongyloides stercoralis-specific IgG4 antibody titer with the efficacy of treatment of strongyloidiasis.
abstract: It is difficult to completely eradicate strongyloidiasis, a human intestinal nematode infection with Strongyloides stercoralis with drugs, especially in males. To find host factors involved in the response to treatment, patients infected with S. stercoralis were examined for S. stercoralis-specific antibody titers and the effect of treatment with albendazole on these titers were determined. The cure rate was slightly but not significantly lower in males than in females (P = 0.108). However, a significantly higher titer of S. stercoralis-specific IgG4 antibody was observed in males than in females (P = 0.0097), and the S. stercoralis-specific IgG4 antibody titer was significantly higher in the male non-cured group than in the cured group (P = 0.035). These results suggest that elevation of the S. stercoralis-specific IgG4 antibody titer is associated with resistance to treatment of S. stercoralis infection, especially in males.
authors.affiliation: Department of Medical Zoology, Saitama Medical School, Morohongo, Moroyama, Iruma-gun, Saitama 350-0495, Japan. satoma@saitama-med.ac.jp
authors.forename: Masao
authors.initials: M
authors.lastname: Satoh
authors.forename: Hiromu
authors.initials: H
authors.lastname: Toma
authors.forename: Susumu
authors.initials: S
authors.lastname: Kiyuna
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Shiroma
authors.forename: Akatsuki
authors.initials: A
authors.lastname: Kokaze
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D000909:Antibodies, Helminth / Q000096:biosynthesis / Q000097:blood; D004351:Drug Resistance / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008297:Male; D012737:Sex Factors; D017171:Strongyloides stercoralis / Q000187:drug effects* / Q000276:immunology; D013322:Strongyloidiasis / Q000188:drug therapy / Q000276:immunology* / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D000909:Antibodies, Helminth; D007074:Immunoglobulin G