[Gout].
In the presence of a clinical acute monoarthritis, a differential diagnosis has to be made between septic arthritis, gout and diffuse chondrocalcinosis. Gout comes from a purine nucleotide metabolism disorder leading to serum urate level elevation. This hyperuricemia can lead to the deposition of monosodium urate crystals in the joints, causing acute attacks. After long-term evolution, others tissues as the kidneys can be involved: it is chronic gout. The definite diagnosis is based on the presence of monosodium urate crystals in the joint fluid. The diagnosis of gout should prompt a search for associated medical conditions that may affect both urate levels and longevity. These include alcoholism, various nephropathies, myeloproliferative disorders, and hypertension.
Leclercq
P
P
Université de Liège.
Malaise
M G
MG
D001170:Arthritis, Infectious / Q000175:diagnosis; D015897:Comorbidity; D003937:Diagnosis, Differential; D006073:Gout / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
D006074:Gout Suppressants; D014527:Uric Acid