Exercise training improves cardiac function postinfarction: special emphasis on recent controversies on na+/ca2+ exchanger.
Exercise training instituted after myocardial infarction improves many steps involved in cardiac excitation-contraction coupling. Focusing on Na/Caexchange, current controversies regarding whether it mediates Cainflux during an action potential, whether it is increased or decreased in disease models, whether protein kinase A alters its activity, and whether exercise training affects its function are reviewed. Finally, a novel target for exercise training in the heart is suggested.
Cheung
Joseph Y
JY
Weis Center for Research, Geisinger Medical Center, Danville, PA 17822, USA. jcheung@geisinger.edu
Song
Jianliang
J
Rothblum
Lawrence I
LI
Zhang
Xue-Qian
XQ
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D048429:Cell Size / Q000187:drug effects; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D051381:Rats; D019831:Sodium-Calcium Exchanger / Q000378:metabolism*
D019831:Sodium-Calcium Exchanger; D017868:Cyclic AMP-Dependent Protein Kinases; D002118:Calcium