Isoniazid and hypoglycaemia in a premature infant.
Severe hypoglycaemia requiring more than 20 mg/kg per minute glucose infusion was seen in a premature infant. The infant was born to a woman with active tuberculosis, and she was on prophylactic isoniazid. Discontinuation of isoniazid resulted in prompt recovery of hypoglycaemia. Further pharmacological studies may be needed to establish a cause and effect relationship.
Ovali
F
F
Neonatal Unit, Department of Obstetrics and Gynecology, Istanbul Medical Faculty, Istanbul University, Turkey. fovali@yahoo.com
Samanci
N
N
Sevinç
E
E
Dağoğlu
T
T
D000904:Antibiotics, Antitubercular / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy*
D000904:Antibiotics, Antitubercular; D007538:Isoniazid