title: Preemptive meloxicam for postoperative pain relief after abdominal hysterectomy.
abstract: OBJECTIVE
  This study was conducted to evaluate the analgesic efficacy of meloxicam in abdominal hysterectomy.
  
  
  METHODS
  The study population consisted of 52 patients scheduled for total abdominal hysterectomy who were ASA 1 or 2 physical status female. Patients were allocated randomly to receive orally either 15 mg of meloxicam (Group M, n = 27) or placebo (Group P, n = 25) before anesthesia induction. After intravenous administration of 1.5 mg kg(-1) of tramadol, anesthesia was induced with an intravenous loading dose of 1-2 mg kg(-1) propofol. Anesthesia was maintained on intravenous infusion of propofol at 6-12 mg kg(-1) h plus tramadol at 1 mg kg(-1) h(-1), vecuronium, and a 2:1 nitrous oxide-oxygen mixture.
  
  
  RESULTS
  The relative propofol consumption was lower in Group M than in Group P, (p < 0.05). The time for analgesic rescue decreased in the order Group M > Group P (p < 0.01). The degree of sedation was similar between the groups (p > 0.05) and the visual analog scores (10-cm scale) and verbal rating scale data differences were present in the first 2 h only (p < 0.05). When side-effects were evaluated nausea and vomiting were found to be lower in group M than in group P (p < 0.05).
  
  
  CONCLUSIONS
  Preemptive meloxicam provided better postoperative analgesia than placebo.
authors.affiliation: Department of Anaesthesiology and Reanimation, Ege University Hospital, Izmir, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Akarsu
authors.forename: S
authors.initials: S
authors.lastname: Karaman
authors.forename: F
authors.initials: F
authors.lastname: Akercan
authors.forename: M
authors.initials: M
authors.lastname: Kazandi
authors.forename: M S
authors.initials: MS
authors.lastname: Yucebilgin
authors.forename: V
authors.initials: V
authors.lastname: Firat
mesh_terms: D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007044:Hysterectomy; D000077239:Meloxicam; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000473:pathology; D015742:Propofol / Q000008:administration & dosage; D013843:Thiazines / Q000008:administration & dosage / Q000627:therapeutic use*; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D018686:Anesthetics, Intravenous; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam; D015742:Propofol