Three new glutarimide alkaloids from Croton cuneatus.
Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolation of the new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along with the known compounds julocrotonine (4), lichexanthone (5) and selin-11-en-4alpha-ol (6). The structures of the new compounds were established by spectral methods. The in vitro cytotoxic activity of Compounds 1-6 was evaluated against six human tumor cells lines.
Suárez
Alírica I
AI
Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40109, Caracas, Venezuela. asuarez@strix.ciens.ucv.ve
Blanco
Zuleyma
Z
Delle Monache
Franco
F
Compagnone
Reinaldo S
RS
Arvelo
Francisco
F
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D029802:Croton; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010881:Piperidones / Q000737:chemistry / Q000494:pharmacology; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010881:Piperidones; D010936:Plant Extracts; C007864:glutarimide