title: Pleural mesothelioma with cutaneous extension to chest wall scars.
abstract: BACKGROUND
  Cutaneous mesothelioma is rare but may occur following local surgical procedures for visceral mesothelioma or as a metastasis.
  
  
  METHODS
  A patient with pleural mesothelioma, who developed papules within chest wall scars, 14 and 15 months after pleural biopsy and thoracentesis, respectively, is reported.
  
  
  RESULTS
  Histopathology showed an epithelioid tumor forming tubulopapillary and glandular structures. The diagnosis of mesothelioma was confirmed with immunohistochemistry. Tumor cells stained characteristically for low-molecular-weight cytokeratins 5/6, calretinin, and vimentin and were negative for mucicarmine, carcinoembryonic antigen, thyroid transcription factor 1, prostate-specific antigen, gross cystic disease fluid protein, S-100, factor VIII, and CD31.
  
  
  CONCLUSIONS
  Histologically, mesothelioma may resemble a primary adnexal neoplasm, metastatic adenocarcinoma, or angiosarcoma. Immunohistochemistry can clarify the diagnosis. Clinicians should be aware of the varied presentations of mesothelioma, as cutaneous presentations are becoming increasingly common.
authors.affiliation: Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: Sherry
authors.initials: S
authors.lastname: Shieh
authors.forename: Marcelle
authors.initials: M
authors.lastname: Grassi
authors.forename: James K
authors.initials: JK
authors.lastname: Schwarz
authors.forename: Richard T
authors.initials: RT
authors.lastname: Cheney
mesh_terms: D000368:Aged; D002921:Cicatrix / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008654:Mesothelioma / Q000378:metabolism / Q000556:secondary*; D010997:Pleural Neoplasms / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D035441:Thoracic Wall / Q000473:pathology*