title: Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer.
abstract: OBJECTIVE
  Investigation of possible effects of aqueous extract of Urtica dioica leaves on adenosine deaminase activity in prostate tissue from patients with prostate cancer.
  
  
  METHODS
  Ten prostate tissues from patients with pathologically proven localized prostate cancer (Gleason scores 4 to 7) were used in the study. In the tissues, ADA activities with and without preincubation with different amounts of Urtica dioica extracts were performed.
  
  
  RESULTS
  Aqueous extract of Urtica dioica results in significant inhibition on adenosine deaminase (ADA) activity of prostate tissue.
  
  
  CONCLUSIONS
  ADA inhibition by Urtica dioica extract might be one of the mechanisms in the observed beneficial effect of Urtica dioica in prostate cancer.
authors.affiliation: Ankara University, School of Medicine, Department of Biochemistry, Ankara, Turkey. ilker_durak@yahoo.com
authors.forename: Ilker
authors.initials: I
authors.lastname: Durak
authors.forename: Hasan
authors.initials: H
authors.lastname: Biri
authors.forename: Erdinç
authors.initials: E
authors.lastname: Devrim
authors.forename: Sinan
authors.initials: S
authors.lastname: Sözen
authors.forename: Aslihan
authors.initials: A
authors.lastname: Avci
mesh_terms: D000243:Adenosine Deaminase / Q000187:drug effects* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000201:enzymology*; D014407:Tumor Cells, Cultured; D026982:Urtica dioica / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D004247:DNA; D000243:Adenosine Deaminase