title: Phenylhomophthalimide-type NOS inhibitors derived from thalidomide.
abstract: Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.
authors.affiliation: Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Noguchi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sano
authors.forename: Rumiko
authors.initials: R
authors.lastname: Shimazawa
authors.forename: Aya
authors.initials: A
authors.lastname: Tanatani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyachi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D010797:Phthalimides / Q000737:chemistry / Q000494:pharmacology*; D013792:Thalidomide / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; C496608:Phenylhomophthalimide; D010797:Phthalimides; D013792:Thalidomide; D019001:Nitric Oxide Synthase