title: A quantitative contour analysis of axisymmetric vesicles spontaneously adhering onto a substrate.
abstract: The determination of membrane-substrate profile for adherent vesicle using confocal reflectance interference contrast microscopy (C-RICM) has pushed for the need of advanced mechanics model for interpreting adhesion mechanisms. In this work, a model for vesicles or cells adhesion is established, the governing equation is derived from the variation of the potential energy at the cohesive zone. A closed-form solution is found for vesicle spontaneously adheres to a substrate when its shear modulus, micro vanishes. Based on the model and C-RICM experiments the magnitude of the adhesion force is calculated for a lipid vesicle adheres to a glass substrate.
authors.affiliation: School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore. mtxiao@ntu.edu.sg
authors.forename: Tan
authors.initials: T
authors.lastname: Xiao
authors.forename: Ning
authors.initials: N
authors.lastname: Fang
authors.forename: Vincent
authors.initials: V
authors.lastname: Chan
authors.forename: Kin
authors.initials: K
authors.lastname: Liao
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D055592:Biophysical Phenomena; D001703:Biophysics; D002448:Cell Adhesion; D004548:Elasticity; D008051:Lipid Bilayers; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D018613:Microscopy, Confocal; D015233:Models, Statistical; D008962:Models, Theoretical; D013314:Stress, Mechanical; D000267:Tissue Adhesions
chemical_list: D001672:Biocompatible Materials; D008051:Lipid Bilayers; D008055:Lipids; D008081:Liposomes