title: Adiponectin and the systemic inflammatory response in weight-losing patients with non-small cell lung cancer.
abstract: The aim of the present study was to examine the relationship between adiponectin and the systemic inflammatory response in weight-losing patients with non-small cell lung cancer (NSCLC). Measurement of anthropometry, acute phase proteins, interleukin-6, leptin (total and free) and adiponectin were carried out on healthy subjects (n = 13) and non-small cell lung cancer patients with weight loss (n = 20). The groups were age and sex matched. Compared with the controls the cancer group had a lower BMI (p < 0.01), mid-upper arm circumference (p < 0.001), triceps skinfold thickness (p < 0.05) and circulating concentrations of albumin (p < 0.001), haemoglobin (p < 0.05), free and total leptin (p < 0.05) and adiponectin (p < 0.01). In contrast, the cancer group had elevated circulating concentrations of interleukin-6 and C-reactive protein concentrations (p < 0.001). In the cancer group circulating adiponectin concentrations were significantly inversely correlated with both free (rs = -0.675, p = 0.001) and total leptin concentrations (rs = -0.690, p = 0.001). However, neither weight loss, interleukin-6 or C-reactive protein concentrations were correlated with either adiponectin, free or total leptin concentrations in the cancer group. These results suggest that adipokine production is normal and is unlikely to play a major role in the abnormal fat metabolism in weight-losing cancer patients.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK.
authors.forename: Nigel B
authors.initials: NB
authors.lastname: Jamieson
authors.forename: Duncan J F
authors.initials: DJ
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Michael Wallace
authors.forename: Donald C
authors.initials: DC
authors.lastname: McMillan
mesh_terms: D052242:Adiponectin; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000473:pathology; D005223:Fats / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015431:Weight Loss
chemical_list: D052242:Adiponectin; D005223:Fats; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D002097:C-Reactive Protein