title: Efficacy of combined surgery and irradiation for localized Ewings sarcoma family of tumors.
abstract: BACKGROUND
  Local tumor control for patients with Ewings sarcoma family of tumors (ESFT) is favorable when the primary tumor is resectable or small. Local failure rates for patients who received combined surgery and RT were reviewed to determine outcome and prognostic factors.
  
  
  METHODS
  We performed a retrospective review of all patients with localized ESFT treated with combined definitive surgery and RT between 1978 and 2001, at St. Jude Children's Research Hospital. Rates of local failure, survival, and prognostic factors for recurrence were determined in 39 patients who received combined local therapy. Systemic treatment included vincristine, actinomycin D, cyclophosphamide, and doxorubicin (6 patients), with the addition of ifosfamide and etoposide (33 patients).
  
  
  RESULTS
  With a median follow-up of 8.7 years the 5- and 8-year survival estimates were 89.2 +/- 5.4% and 82.8 +/- 7.3%. The 8-year incidence of local failure was 10.8 +/- 5.2%. The 8-year local failure rate for patients with positive surgical margins was 17% and for negative surgical margins 5% (P = 0.25). Overall survival was improved for patients with negative surgical margins (94 vs. 71%, P = 0.052). Tumor size, site, histologic response, and radiation dose did not significantly alter the rate of local failure.
  
  
  CONCLUSIONS
  Patients with ESFT managed with definitive surgery and irradiation have favorable local control rates. Even among patients with unfavorable prognostic factors local tumor control remained excellent.
authors.affiliation: Division of Radiation Oncology, Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. matthew.krasin@stjude.org
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Krasin
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Davidoff
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Billups
authors.forename: Christine E
authors.initials: CE
authors.lastname: Fuller
authors.forename: Michael D
authors.initials: MD
authors.lastname: Neel
authors.forename: Larry E
authors.initials: LE
authors.lastname: Kun
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Merchant
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome