title: Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis.
abstract: Mastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.
authors.affiliation: Unidad de Mastocytosis, Laboratorio K. Frank Austen, Hospital Ramón y Cajal, Madrid, Spain. lescribano.hrc@salud.madrid.org
authors.forename: Luis
authors.initials: L
authors.lastname: Escribano
authors.forename: Andrés
authors.initials: A
authors.lastname: Garca-Montero
authors.forename: Rosa
authors.initials: R
authors.lastname: Núñez-López
authors.forename: Javier
authors.initials: J
authors.lastname: López-Jiménez
authors.forename: Julia
authors.initials: J
authors.lastname: Almeida
authors.forename: Aranzazu
authors.initials: A
authors.lastname: Prados
authors.forename: Alberto
authors.initials: A
authors.lastname: Orfao
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy