title: Association between lenticulostriate vasculopathy (LSV) and neonatal intraventricular hemorrhage (IVH).
abstract: OBJECTIVE
  To determine whether there is an unconfounded association between neonatal intraventricular hemorrhage (IVH) and lenticulostriate vasculopathy (LSV (also known as thalamostriate or mineralizing vasculopathy)).
  
  
  METHODS
  During the conduct of the Magnesium and Neurologic Endpoints Trial (MagNET), a randomized controlled trial involving maternal, hence fetal, exposure to antenatal magnesium sulfate in the context of preterm labor, head ultrasounds were obtained for each of the surviving neonates. Because of our previous experience in the diagnosis of LSV, when ascertaining the presence of IVH, as called for by the research protocol of our study, the presence or absence of LSV was also determined.
  
  
  RESULTS
  We found LSV to be relatively prevalent (10% (14 of 140) among surviving babies). More importantly, it was significantly associated with the occurrence of neonatal IVH, even when controlled for possible confounding (adjusted OR 9.8, 95% confidence interval 1.3 to 73.1; p=0.03).
  
  
  CONCLUSIONS
  Given the known relationships between IVH and neonatal morbidity and mortality, the finding of a statistically significant association between neonatal IVH and LSV may suggest more substantial implications for the latter than previously believed.
authors.affiliation: Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL 60153, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Mittendorf
authors.forename: Robert
authors.initials: R
authors.lastname: Covert
authors.forename: Peter G
authors.initials: PG
authors.lastname: Pryde
authors.forename: Kwang-Sun
authors.initials: KS
authors.lastname: Lee
authors.forename: Tamar
authors.initials: T
authors.lastname: Ben-Ami
authors.forename: David
authors.initials: D
authors.lastname: Yousefzadeh
mesh_terms: D020144:Basal Ganglia Cerebrovascular Disease / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn