title: Congenital (infantile) pseudarthrosis of the fibula associated with osteofibrous dysplasia.
abstract: We describe a recently noted association of congenital (infantile) pseudarthrosis of the lower leg with osteofibrous dysplasia. The patient was a 2-year-old boy who presented with a deformed left ankle joint and three cutaneous cafe-au-lait spots. Radiography demonstrated pseudarthrosis of the left distal fibula and a round lucent lesion adjacent to the proximal part of the pseudarthrosis. Histologically, the surgically removed fibula with pseudarthrosis showed a fibromatosis-like fibrovascular proliferation and nonspecific reparative changes. The focal lucent area demonstrated a fibro-osseous lesion, which was histologically identical to osteofibrous dysplasia. This case provides further evidence that osteofibrous dysplasia may be associated with congenital (infantile) pseudarthrosis of the lower leg.
authors.affiliation: Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Hisaoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ohguri
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Aoki
authors.forename: Sumika
authors.initials: S
authors.lastname: Okamoto
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Okimoto
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ishida
mesh_terms: D002675:Child, Preschool; D005360:Fibula / Q000473:pathology*; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D011542:Pseudarthrosis / Q000150:complications* / Q000151:congenital* / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications*