Protein recycling is a major component of post-irradiation recovery in Deinococcus radiodurans strain R1.
Exposure to 6kGy dose of (60)Co gamma-rays resulted in immediate growth arrest, followed by complete recovery of Deinococcus radiodurans strain R1 cells. Selective degradation and resynthesis of several predicted highly expressed proteins (including major chaperones, key TCA cycle enzymes, and few stress proteins) and several hypothetical proteins marked the lag period, preceding resumption of growth. A major exercise in protein recycling appears to be an integral component of post-irradiation recovery in D. radiodurans and complements the extensive DNA repair, characteristic of this extremely radioresistant bacterium.
Joshi
Bhakti
B
Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Schmid
Roland
R
Altendorf
Karlheinz
K
Apte
Shree Kumar
SK
D000222:Adaptation, Physiological / Q000502:physiology; D001426:Bacterial Proteins / Q000378:metabolism*; D002455:Cell Division / Q000528:radiation effects; D034301:Deinococcus / Q000166:cytology / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects*; D020543:Proteome / Q000378:metabolism; D011836:Radiation Tolerance / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology / Q000528:radiation effects; D013045:Species Specificity
D001426:Bacterial Proteins; D020543:Proteome