Sex-specific development of cortical monoamine levels in mouse.
Several mental health disorders exhibit sex differences in monoamine levels associated with dimorphic cortical ontogeny. Studies in rodents support the notion that monoamines can profoundly modulate morphogenesis. Here, we show significant sex and hemisphere differences in BALB/cByJ mice on postnatal day 3 for dopamine (DA) and serotonin (5-TH), supporting the notion that sex differences in early monoaminergic ontogeny may result in dimorphic cortical development. Such sex differences may also influence differential behavioral and/or clinical outcomes.
Connell
Shelley
S
Doctoral Studies Program in Math and Science Education, Morgan State University, 1700 E. Cold Spring Ln., Baltimore, MD 21251, USA.
Karikari
Collins
C
Hohmann
Christine F
CF
D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D015306:Biogenic Monoamines / Q000378:metabolism*; D001923:Brain Chemistry / Q000502:physiology; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012727:Sex Characteristics
D015306:Biogenic Monoamines