[The effect of non-steroidal anti-inflammatory drugs in upper gastrointestinal bleeding].
OBJECTIVE
To evaluate the association between non-steroidal anti-inflammatory drugs (NSAIDs) use and upper gastrointestinal (UGI) bleeding, we performed a case-control study at the six University affiliated hospitals for one year.


METHODS
Case and control subjects matched for age and sex were selected by endoscopy. Subjects were asked for the use of NSAIDs, past medical history, history of other medications, and smoking. The age and sex adjusted risk for UGI bleeding with NSAIDs use was compared between the case and control groups.


RESULTS
The odd ratios of UGI bleeding with NSAIDs intake adjusted for past medical and medication history, past medical history only, and medication history only were 5.0, 5.0, and 1.7, respectively. The cases had significantly more history of NSAIDs intake, more diseases in medical history, and more medications other than NSAIDs compared to the controls. There was no relationship between UGI bleeding and concomitant medications in the both groups.


CONCLUSIONS
This multicenter study suggests that a history of NSAIDs intake is strongly associated with UGI bleeding in Korea.
Lee
Sang Woo
SW
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Kim
Hak Yang
HY
Park
Soo Heon
SH
Hahm
Ki Baik
KB
Bae
Jong Myon
JM
Jung
Hyun Chae
HC
Kim
Jin Ho
JH
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016022:Case-Control Studies; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans
D000894:Anti-Inflammatory Agents, Non-Steroidal