title: Evaluation of vitamin E against deltamethrin toxicity in broiler chicks.
abstract: Deltamethrin toxicity was studied in broilers and vitamin E was evaluated for therapeutic management. Day old male broiler chicks were randomly divided into 3 groups consisting of 6 chicks in each. Group 1 was maintained as control for 6 wks, group 2 was fed on deltamethrin (100 mg/kg feed) for 6 wks and group 3 was fed on deltamethrin for the first 4 wks and during the subsequent 2 wks with vitamin E (300 mg/kg feed) with out deltamethrin. Weekly body weights, feed conversion ratio, glutathione (GSH) concentration and high density lipoproteins (HDL) were significantly (P < 0.05) reduced, while the activities of glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), catalase, aspartate aminotransferase (AST) and lactate dehydrogenase (LDH), and the lipid profile and renal biomarkers were increased significantly (P < 0.05) in group 2 and 3 at the end of 4th wk as compared to group 1. Following treatment with vitamin E during the last 2 wks in group 3, all the parameters in study revealed improvement. From this study, it is concluded that deltamethrin induces toxicity by oxidative damage in biological system and supplementing vitamin E in feed is useful in treating accidental toxicity.
authors.affiliation: Department of Pharmacology & Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad 500 030.
authors.forename: U
authors.initials: U
authors.lastname: Jayasree
authors.forename: A Gopala
authors.initials: AG
authors.lastname: Reddy
authors.forename: K S
authors.initials: KS
authors.lastname: Reddy
authors.forename: Y
authors.initials: Y
authors.lastname: Anjaneyulu
authors.forename: B
authors.initials: B
authors.lastname: Kalakumar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002645:Chickens / Q000097:blood*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005609:Free Radicals / Q000097:blood; D008297:Male; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D009570:Nitriles; D011722:Pyrethrins; D014810:Vitamin E; C017180:decamethrin