title: [Paragangliomas in the head-/neck region. I: Classification and diagnosis].
abstract: Paragangliomas of the head and neck occur sporadically or are hereditary. The hereditary phenotype characteristically occurs between the 2nd and 3rd decade of life; the sporadic phenotype beyond the 4th decade. The hereditary phenotype "paraganglioma syndrome type 1" frequently shows multilocular tumor manifestations and rarely cases of maltransformation. Therefore, paragangliomas should be considered a systemic disease. For diagnosis, an interdisciplinary, step by step procedure is mandatory comprising genetic screening, whole body medical check-up including catecholamine metabolism, and optionally an 18F-Dopa-PET and localised imaging procedures.
authors.affiliation: Universitätsklinik für Hals-Nasen-Ohren-Heilkunde und Poliklinik des Universitätsklinikum Freiburg. schipper@hno.ukl.uni-freiburg.de
authors.forename: J
authors.initials: J
authors.lastname: Schipper
authors.forename: C C
authors.initials: CC
authors.lastname: Boedeker
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: H P H
authors.initials: HP
authors.lastname: Neumann
mesh_terms: D003937:Diagnosis, Differential; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006258:Head and Neck Neoplasms / Q000145:classification* / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D010235:Paraganglioma / Q000145:classification* / Q000175:diagnosis* / Q000235:genetics; D010346:Patient Care Management / Q000379:methods*; D017410:Practice Guidelines as Topic