title: Delaying the mitochondrial decay of aging.
abstract: Mitochondrial dysfunction may be a principal underlying event in aging, including the degenerative diseases of aging such as brain degeneration. Mitochondria provide energy for basic metabolic processes, and their decay with age impairs cellular metabolism and leads to cellular decline. Progress over the last decade in delaying the mitochondrial decay of aging is reviewed.
authors.affiliation: University of California, Berkeley, and Children's Hospital Oakland Research Institute, USA. bames@chori.org
authors.forename: Bruce N
authors.initials: BN
authors.lastname: Ames
mesh_terms: D000108:Acetylcarnitine / Q000378:metabolism; D000375:Aging; D000818:Animals; D001710:Biotin / Q000172:deficiency; D001921:Brain / Q000473:pathology; D003300:Copper / Q000172:deficiency; D006418:Heme / Q000172:deficiency; D006801:Humans; D007700:Kinetics; D008928:Mitochondria / Q000473:pathology*; D010205:Pantothenic Acid / Q000172:deficiency / Q000378:metabolism; D011485:Protein Binding; D008063:Thioctic Acid / Q000378:metabolism; D025101:Vitamin B 6 / Q000378:metabolism; D014803:Vitamin B Complex / Q000378:metabolism; D015032:Zinc / Q000172:deficiency
chemical_list: D014803:Vitamin B Complex; D010205:Pantothenic Acid; D006418:Heme; D000108:Acetylcarnitine; D001710:Biotin; D008063:Thioctic Acid; D003300:Copper; D025101:Vitamin B 6; D015032:Zinc