title: Is there significant improvement in neonatal outcome after treating pPROM mothers with amnio-infusion?
abstract: The aim of this study was to determine the effects of amnio-infusion treatment on fetal and neonatal mortality and neonatal pulmonary development in women with singleton pregnancies and premature rupture of the membranes occurring at a gestational age of <26 weeks and who had severe oligohydramnios. The treated group of 45 consenting women received serial amnio-infusion and was compared with the control group of 44 women who underwent waiting treatment. Our study confirmed a higher number of live births in the treated group, especially in cases with a gestational age at rupture (GAR) of <20 weeks. Furthermore, even if GAR is an important factor for predicting pulmonary hypoplasia, amnio-infusion treatment reduces the probability of pulmonary hypoplasia. In fact, over 20 weeks, amnio-infusion treatment significantly reduces the risk of pulmonary hypoplasia even if normal lung development cannot be guaranteed.
authors.affiliation: Division of Neonatology, Catholic University 'Sacred Heart', Rome, Italy. piadc@katamail.com
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: De Carolis
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
authors.forename: Marco
authors.initials: M
authors.lastname: De Santis
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Piersigilli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vento
authors.forename: Alessandro
authors.initials: A
authors.lastname: Caruso
mesh_terms: D000328:Adult; D000653:Amniotic Fluid; D001724:Birth Weight; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications / Q000628:therapy*; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D016104:Oligohydramnios / Q000150:complications; D011247:Pregnancy; D011256:Pregnancy Outcome