Normal values for CD4 and CD8 lymphocyte subsets in healthy Chinese adults from Shanghai.
The aim of this study was to establish reference ranges for lymphocyte subsets in Chinese adults. Venous blood specimens were obtained from 614 healthy, human immunodeficiency virus (HIV)-seronegative adults in Shanghai. Flow cytometry was used to determine percentages and absolute numbers of CD4 and CD8 T lymphocytes. Mean values for CD4 and CD8 lymphocytes were 727 and 540 cells/microl, respectively, yielding a CD4/CD8 ratio of 1.49. While CD8 lymphocyte values varied with age and gender, no significant differences in CD4 lymphocyte values were observed. Shanghai adults had approximately 100 fewer CD4 lymphocytes/microl on average than Caucasians, suggesting that lower CD4 lymphocyte cutoffs for classifying and monitoring HIV infection may be needed in China.
Jiang
Weiming
W
Department of Infectious Diseases, Fudan University Huashan Hospital, Shanghai, China.
Kang
Laiyi
L
Lu
Hong-Zhou
HZ
Pan
Xiaozhang
X
Lin
Qingneng
Q
Pan
Qichao
Q
Xue
Yile
Y
Weng
Xinhua
X
Tang
Yi-Wei
YW
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People / Q000208:ethnology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002681:China / Q000208:ethnology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018655:Lymphocyte Count / Q000592:standards*; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D044465:White People / Q000208:ethnology