title: Pax6 is a direct, positively regulated target of the circadian gene Clock.
abstract: Clock is a member of a highly conserved transcription control network that underlies the circadian cycle. During early embryogenesis, its expression is developmentally regulated and may be required for the normal development of the head. In this report, the transcription factor Pax6, a highly conserved regulator of anterior development, is shown to be a direct target of Clock regulation.
authors.affiliation: Department of Basic Medical Sciences, St. George's Hospital Medical School, Cranmer Terrace, London, United Kingdom. rmorgan@sghms.ac.uk
authors.forename: Richard
authors.initials: R
authors.lastname: Morgan
mesh_terms: D000818:Animals; D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D001665:Binding Sites; D056926:CLOCK Proteins; D003513:Cycloheximide / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D005136:Eye Proteins; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D005938:Glucocorticoids / Q000494:pharmacology; D049452:Green Fluorescent Proteins / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008156:Luciferases / Q000378:metabolism; D008957:Models, Genetic; D008969:Molecular Sequence Data; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012097:Repressor Proteins; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013045:Species Specificity; D015534:Trans-Activators / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D015854:Up-Regulation; D014981:Xenopus
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D056926:CLOCK Proteins; D003513:Cycloheximide; D004268:DNA-Binding Proteins; D003907:Dexamethasone; D005136:Eye Proteins; D005938:Glucocorticoids; D049452:Green Fluorescent Proteins; D018398:Homeodomain Proteins; D008156:Luciferases; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011500:Protein Synthesis Inhibitors; D012313:RNA; D012333:RNA, Messenger; D012097:Repressor Proteins; D015534:Trans-Activators; C093970:NEUROD1 protein, human; C000605730:PAX6 protein, human; C538943:CLOCK protein, human