Amount of DNA in plasma and cancer risk: a prospective study.
Levels of plasma DNA concentrations in cancer patients have been shown to be higher than the plasma DNA concentrations found in healthy subjects. The value of plasma DNA levels for development of neoplastic or pulmonary disease was evaluated in a large prospective study. Plasma samples (n = 1,184) were analyzed from 776 controls, 359 cases of cancer (lung, bladder, oral cavity, pharynx, larynx, leukemia) and 49 deaths from chronic obstructive pulmonary disease (COPD), including never smokers and ex-smokers, from 9 countries across Europe. The amount of plasma DNA was variable across the European Prospective Investigation into Cancer and Nutrition (EPIC) centers. High DNA concentrations in some centers might be due to the type of population recruited and/or the treatment of the samples. An elevated and statistically significant odds ratio (OR) was found for COPD deaths (OR = 2.53; 95% CI = 1.06-6.02), while nonsignificant increased ORs were present for oral cancers, cancers of the pharynx and larynx and leukemia. When the analyses were stratified by time since recruitment (below or above 36 months), the increased ORs were limited to the more recent period of recruitment, i.e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPD deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% CI = 1.20-4.67).
Gormally
Emmanuelle
E
International Agency for Research on Cancer, Lyon, France.
Hainaut
Pierre
P
Caboux
Elodie
E
Airoldi
Luisa
L
Autrup
Herman
H
Malaveille
Christian
C
Dunning
Alison
A
Garte
Seymour
S
Matullo
Giuseppe
G
Overvad
Kim
K
Tjonneland
Anne
A
Clavel-Chapelon
Francoise
F
Boffetta
Paolo
P
Boeing
Heiner
H
Trichopoulou
Antonia
A
Palli
Domenico
D
Krogh
Vittorio
V
Tumino
Rosario
R
Panico
Salvatore
S
Bueno-de-Mesquita
H Bas
HB
Peeters
Petra H
PH
Lund
Eiliv
E
Gonzalez
Carlos A
CA
Martinez
Carmen
C
Dorronsoro
Miren
M
Barricarte
Aurelio
A
Tormo
M Jose
MJ
Quiros
J Ramón
JR
Berglund
Goran
G
Hallmans
Goran
G
Day
Nicholas E
NE
Key
Timothy J
TJ
Veglia
Fabrizio
F
Peluso
Marco
M
Norat
Teresa
T
Saracci
Rodolfo
R
Kaaks
Rudolf
R
Riboli
Elio
E
Vineis
Paolo
P
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004247:DNA / Q000097:blood*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000235:genetics; D012307:Risk Factors
D004247:DNA