The scientific rationale and development of an optimized dentifrice for the treatment of dentin hypersensitivity.
OBJECTIVE
To describe the development of a new dentin hypersensitivity treatment, Colgate Sensitive Maximum Strength dentifrice, containing 5% potassium nitrate as the anti-hypersensitivity active agent. The objective was to develop a home-use hypersensitivity dentifrice that would be superior to the market leader, improving on what is available, which also contains 5% potassium nitrate as the anti-hypersensitivity active agent.


METHODS
In vivo (clinicals, taste evaluation and rat caries), in vitro (potassium flux) and analytical (rheology, dispensed volume, scanning electron microscopy, electron scanning chemical analysis and radioactive dentin abrasion) methods were performed.


RESULTS
The objective was accomplished with the development of a new activated silica technology that resulted in enhanced potassium ion activity. In vitro documentation, supported by clinical studies, demonstrated that the resulting formula is more effective than the market leader for relief of hypersensitivity pain. Fast pain relief in less than 2 weeks and long-lasting protection against pain with regular use have also been clinically documented. Furthermore, FDA-required in vivo and in vitro studies indicate that this formula, which contains 0.45% stannous fluoride (1100 ppm fluoride) as the anti-caries active agent, is effective against caries. Good taste, acceptable rheology, acceptable abrasivity, and cosmetic and chemical stability have all been engineered into this unique dentin hypersensitivity treatment. In summary, a highly efficacious consumer friendly treatment for dentin hypersensitivity has been developed.
Tavss
Edward A
EA
Advanced Oral Care Technology, Colgate-Palmolive Technology Center, Piscataway, NJ 08855, USA.
Fisher
Steven W
SW
Campbell
Shannon
S
Bonta
Yolanda
Y
Darcy-Siegel
Joann
J
Blackwell
Bernie L
BL
Volpe
Anthony R
AR
Miller
Steven E
SE
D000818:Animals; D002327:Cariostatic Agents / Q000627:therapeutic use; D045424:Complex Mixtures; D003731:Dental Caries / Q000188:drug therapy; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D019234:Dentinal Fluid / Q000502:physiology; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009566:Nitrates / Q000627:therapeutic use*; D010710:Phosphates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012212:Rheology; D012822:Silicon Dioxide; D012969:Sodium Fluoride / Q000627:therapeutic use; D013649:Taste
D002327:Cariostatic Agents; C408633:Colgate Winterfresh Fluoride Gel; D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; C097427:Sensodyne; C444700:colgate sensitive; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D005459:Fluorides; C023844:potassium nitrate