title: Diagnosis and treatment of malignant pancreatic endocrine tumour.
abstract: OBJECTIVE
  To summarize our experience in the diagnosis and treatment of malignant pancreatic endocrine tumour.
  
  
  METHODS
  We retrospectively reviewed 36 cases of malignant pancreatic endocrine tumours in our hospital from July 1987 to April 2002, and summarized its clinical features.
  
  
  RESULTS
  Liver metastasis was the main malignant manifestation of malignant pancreatic endocrine tumours (incidence rate 72.2%). Removals of primary lesion and isolated hepatic metastatic lesion were means of curative therapy. Interventional chemotherapy was an important adjuvant treatment.
  
  
  CONCLUSIONS
  Comprehensive therapy plays an important role in improving the prognosis of malignant pancreatic endocrine tumour.
authors.affiliation: Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Yu-Pei
authors.initials: YP
authors.lastname: Zhao
authors.forename: Chia-I
authors.initials: CI
authors.lastname: Lee
authors.forename: Quan
authors.initials: Q
authors.lastname: Liao
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018273:Carcinoma, Islet Cell / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D015408:Gastrinoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D005935:Glucagonoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010179:Pancreas / Q000601:surgery*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies