title: Automated flow-through synthesis of heterocyclic thioethers.
abstract: The fully automated, sequential flow-through synthesis of a 44-member array of thioethers 10[1-4,1-11] employing a resin "capture and release" reactor column is described. The array incorporates four different heterocyclic scaffolds, and the synthesis was performed using a custom-built robotic synthesizer that is able to (i) load and regenerate the reactor column and (ii) array each product into a single vial using UV threshold detection. All the compounds were obtained in high yield (>75%) and excellent purity (>95%) without the need for further purification.
authors.affiliation: GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Jönsson
authors.forename: Brian H
authors.initials: BH
authors.lastname: Warrington
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow