title: Myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty.
abstract: There is substantial evidence indicating that endogenous opioid peptides are involved in the pathophysiology of myocardial ischemia and reperfusion. We measured the myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty. The results indicate that in patients with coronary artery disease, there was an augmented myocardial concentration of beta-endorphin. Moreover, there was an increased peripheral concentration of beta-endorphin following myocardial ischemia and reperfusion. The data support the previous notion that endogenous opioid peptides are involved in the pathophysiology of ischemic heart disease.
authors.affiliation: Division of Cardiology, Jen Ai Hospital, Tali, Taichung. Taiwan, ROC.
authors.forename: Michael Chich-Kuang
authors.initials: MC
authors.lastname: Chang
authors.forename: Andrew Ying-Siu
authors.initials: AY
authors.lastname: Lee
authors.forename: Wen-Ye
authors.initials: WY
authors.lastname: Lin
authors.forename: Tien-Jen
authors.initials: TJ
authors.lastname: Chen
authors.forename: Miin-Yaw
authors.initials: MY
authors.lastname: Shyu
authors.forename: Wen-Fung
authors.initials: WF
authors.lastname: Chang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D001794:Blood Pressure; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006339:Heart Rate; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000503:physiopathology; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000737:chemistry*; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D001615:beta-Endorphin / Q000032:analysis / Q000097:blood*
chemical_list: D007527:Isoenzymes; D019344:Lactic Acid; D001615:beta-Endorphin; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form