title: Multiple triggers for hyperthermic fatigue and exhaustion.
abstract: It has been proposed that a critical body temperature exists at which muscle activation is impaired through a direct effect of high brain temperature decreasing the central drive to exercise, but other factors may also inhibit performance in the heat. An integrative physiological model is presented to stimulate research into mechanisms of hyperthermic fatigue and exhaustion.
authors.affiliation: Environmental Ergonomics Laboratory, School of Health & Human Performance, Dalhousie University, Halifax, Nova Scotia, Canada. stephen.cheung@dal.ca
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Cheung
authors.forename: Gordon G
authors.initials: GG
authors.lastname: Sleivert
mesh_terms: D001831:Body Temperature / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005334:Fever / Q000378:metabolism / Q000503:physiopathology*; D006359:Heat Exhaustion / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D018763:Muscle Fatigue / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D016207:Cytokines