Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants.
A series of thiourea derivatives (7-23, 25-27) of 1-aminotetrahydronaphthalene (4) and 1-amino-2-hydroxytetrahydronaphthalene (5) were synthesized in single pot in 48-90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14, 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants.
Bhandari
Kalpana
K
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. bhandarikalpana@rediffmail.com
Srivastava
Shipra
S
Shankar
Girija
G
D000818:Animals; D001067:Appetite Depressants / Q000138:chemical synthesis / Q000494:pharmacology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D015394:Molecular Structure; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology
D001067:Appetite Depressants; D013890:Thiourea