Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration.
Positron emission tomography (PET) using [(11)C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [(11)C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [(11)C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.
Henkel
Karsten
K
Department of Neurology, University of Ulm, Ulm, Germany.|Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
Karitzky
Jochen
J
Department of Neurology, University of Ulm, Ulm, Germany.|Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
Schmid
Michaela
M
Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
Mader
Irina
I
Department of Neuroradiology, University of Tübingen, Tübingen, Germany.
Glatting
Gerhard
G
Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
Unger
Jürgen W
JW
Department of Neurology, University of Ulm, Ulm, Germany.
Neumaier
Bernd
B
Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
Ludolph
Albert C
AC
Department of Neurology, University of Ulm, Ulm, Germany.
Reske
Sven N
SN
Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
Landwehrmeyer
G Bernhard
GB
Department of Neurology, University of Ulm, Ulm, Germany.
D000368:Aged; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007546:Isoquinolines; D008279:Magnetic Resonance Imaging; D008297:Male; D017628:Microglia / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D009410:Nerve Degeneration / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A / Q000378:metabolism; D014055:Tomography, Emission-Computed
D007546:Isoquinolines; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A; C037850:PK 11195