Seasonal variation of kaurenoic acid, a hypoglycemic diterpene present in Wedelia paludosa (Acmela brasiliensis) (Asteraceae).
We evaluated the variation of the concentration of kaurenoic acid (1), which is a bioactive diterpene, in leaves, flowers, stems and roots from Wedelia paludosa (Acmela brasiliensis) for different seasons using the HRGC/FID method. The results indicated that the concentration of 1 is higher in the roots and stems during the autumn. The pharmacological results suggested that kaurenoic acid is responsible, at least in part, for the hypoglycemic potential detected in this plant.
Bresciani
Louisiane Faccio V
LF
Departamento de Química, Universidade Federal de Santa Catarina (UFSC), 88040-900, Florianópolis, SC, Brazil.
Yunes
Rosendo Augusto
RA
Bürger
Cristiani
C
De Oliveira
Luis Eduardo
LE
Bóf
Kauê Leal
KL
Cechinel-Filho
Valdir
V
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D004224:Diterpenes / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D006943:Hyperglycemia / Q000097:blood; D007004:Hypoglycemic Agents / Q000032:analysis* / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D012621:Seasons; D031209:Wedelia / Q000737:chemistry*
D001786:Blood Glucose; D004224:Diterpenes; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C051436:kaurenoic acid; D005905:Glyburide