Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum.
Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl (3) extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC (50) value of 3.12 micro M.
Lee
Seung Woong
SW
Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-dong, Yusong-gu, Taejon 305-333, Korea.
Rho
Mun-Chual
MC
Nam
Jung Yeon
JY
Lim
Eun Hee
EH
Kwon
Oh Eok
OE
Kim
Young Ho
YH
Lee
Hyun Sun
HS
Kim
Young Kook
YK
D000475:Alkenes; D000818:Animals; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D005638:Fruit; D006574:Heterocyclic Compounds, 2-Ring; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008517:Phytotherapy; D031701:Piper; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D000097587:Sterol O-Acyltransferase 2
D000475:Alkenes; D004791:Enzyme Inhibitors; D006574:Heterocyclic Compounds, 2-Ring; D010936:Plant Extracts; D002785:Sterol O-Acyltransferase; D000097587:Sterol O-Acyltransferase 2; C492480:guineensine