title: Hemodynamics of microvascular dysfunction in patients with anterior wall acute myocardial infarction.
abstract: This study investigated whether the no-reflow phenomenon in acute myocardial infarction (AMI) is associated with an increase in coronary zero flow pressure (ZFP), a decrease in coronary arterial conductance, or both phenomena. Coronary blood flow velocity and pressure were measured with a Doppler guidewire and a pressure wire, respectively, during vasodilation with adenosine triphosphate after coronary intervention. The data indicate that the no-reflow phenomenon is not necessarily associated with a decrease in coronary arterial conductance but with an increase in ZFP. Greater ZFP is associated with more severe microvascular dysfunction and worse functional outcomes in patients with AMI.
authors.affiliation: Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan. itomd@osk4.3web.ne.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Kazuo
authors.initials: K
authors.lastname: Terai
authors.forename: Katsuomi
authors.initials: K
authors.lastname: Iwakura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawase
authors.forename: Kenshi
authors.initials: K
authors.lastname: Fujii
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D002200:Capillary Resistance; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D012039:Regional Blood Flow