A novel electrode array for diameter-dependent control of axonal excitability: a simulation study.
Electrical extracellular stimulation of peripheral nerve activates the large-diameter motor fibers before the small ones, a recruitment order opposite the physiological recruitment of myelinated motor fibers during voluntary muscle contraction. Current methods to solve this problem require a long-duration stimulus pulse which could lead to electrode corrosion and nerve damage. The hypothesis that the excitability of specific diameter fibers can be suppressed by reshaping the profile of extracellular potential along the axon using multiple electrodes is tested using computer simulations in two different volume conductors. Simulations in a homogenous medium with a nine-contact electrode array show that the current excitation threshold (Ith) of large diameter axons (13-17 microm) (0.6-3.0 mA) is higher than that of small-diameter axons (2-7 microm) (0.4-0.7 mA) with 200-microm axon-electrode distance and 10-micros stimulus pulse. The electrode array is also tested in a three-dimensional finite-element model of the sacral root model of dog (ventral root of S3). A single cathode activates large-diameter axons before activating small axons. However, a nine-electrode array activates 50% of small axons while recruiting only 10% of large ones and activates 90% of small axons while recruiting only 50% of large ones. The simulations suggest that the near-physiological recruitment order can be achieved with an electrode array. The diameter selectivity of the electrode array can be controlled by the electrode separation and the method is independent of pulse width.
Lertmanorat
Zeng
Z
Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA. zxl15@cwru.edu
Durand
Dominique M
DM
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology*; D003198:Computer Simulation; D017076:Computer-Aided Design; D004056:Differential Threshold / Q000502:physiology; D004285:Dogs; D004558:Electric Stimulation / Q000295:instrumentation* / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods; D004567:Electrodes, Implanted; D004867:Equipment Design / Q000379:methods; D005240:Feasibility Studies; D008839:Microelectrodes; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D010525:Peripheral Nerves / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000502:physiology