title: New mouse genetic models for human contraceptive development.
abstract: Genetic strategies for the post-genomic sequence age will be designed to provide information about gene function in a myriad of physiological processes. Here an ENU mutagenesis program (http://reprogenomics.jax.org) is described that is generating a large resource of mutant mouse models of infertility; male and female mutants with defects in a wide range of reproductive processes are being recovered. Identification of the genes responsible for these defects, and the pathways in which these genes function, will advance the fields of reproduction research and medicine. Importantly, this program has potential to reveal novel human contraceptive targets.
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
authors.forename: C
authors.initials: C
authors.lastname: Lessard
authors.forename: J K
authors.initials: JK
authors.lastname: Pendola
authors.forename: S A
authors.initials: SA
authors.lastname: Hartford
authors.forename: J C
authors.initials: JC
authors.lastname: Schimenti
authors.forename: M A
authors.initials: MA
authors.lastname: Handel
authors.forename: J J
authors.initials: JJ
authors.lastname: Eppig
mesh_terms: D000818:Animals; D003270:Contraceptive Agents; D003433:Crosses, Genetic; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007246:Infertility / Q000235:genetics; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics* / Q000502:physiology; D008957:Models, Genetic; D016296:Mutagenesis; D010641:Phenotype; D012098:Reproduction / Q000235:genetics* / Q000502:physiology
chemical_list: D003270:Contraceptive Agents