Nuclear survivin as a biomarker for non-small-cell lung cancer.
Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.
Lu
B
B
Department of Radiation Oncology, Vanderbilt Ingram, Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. bolu@vanderbilt.edu
Gonzalez
A
A
Massion
P P
PP
Shyr
Y
Y
Shaktour
B
B
Carbone
D P
DP
Hallahan
D E
DE
D000368:Aged; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D002467:Cell Nucleus / Q000737:chemistry*; D015853:Cysteine Proteinase Inhibitors / Q000032:analysis*; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000032:analysis*; D008875:Middle Aged; D009363:Neoplasm Proteins; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D000077022:Survivin
C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D015853:Cysteine Proteinase Inhibitors; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin