Metastatic juxtaglomerular cell tumor in a 52-year-old man.
Juxtaglomerular cell tumor is a rare renal neoplasm arising from the juxtaglomerular apparatus. Approximately 70 cases have been reported in the English literature since it was first described by Robertson et al in 1967. This tumor has been considered benign and resection has so far been curative. In this paper, we report the first metastatic juxtaglomerular cell tumor. The 15-cm tumor occurred in the right kidney of a 46-year-old man. It invaded the renal vein, and was treated by radical nephrectomy in 1995. The diagnosis at that time was renal cell carcinoma. The patient was well for 6 years and then developed bilateral lung masses, which were resected. Microscopically, the tumors from the kidney and the lungs were similar, consisting of solid sheets of uniformly round-to-polygonal cells intermixed with abundant delicate vasculature. Both renal and pulmonary tumors were positive for vimentin, renin, and only focally to CD34. Electron microscopic studies performed on the paraffin-embedded renal tumor and formalin-fixed lung tumor revealed the typical rhomboid crystals of proto-renin. In consideration of the characteristic morphologic features, immunohistochemistry, and the presence of rhomboid crystals of proto-renin, the diagnosis was modified to malignant juxtaglomerular cell tumor.
Duan
Xiuzhen
X
Department of Pathology, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA.
Bruneval
Patrick
P
Hammadeh
Rasheed
R
Fresco
Raoul
R
Eble
John N
JN
Clark
Joseph I
JI
Vigneswaran
Wickii T
WT
Flanigan
Robert C
RC
Picken
Maria M
MM
D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D003460:Crystallization; D006801:Humans; D007124:Immunoenzyme Techniques; D007606:Juxtaglomerular Apparatus / Q000648:ultrastructure*; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000032:analysis / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; D014746:Vimentin; D012083:Renin