title: Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis.
abstract: New data support the importance of the innate immune response in the resolution or progression of pulmonary fibrosis. The presence of CXC chemokine receptor 3-expressing cells, specifically pulmonary NK cells, is necessary to produce IFN-gamma. This is critical in the polarization of the immune response to injury toward a favorable Th1 response and resolution. In contrast, a Th2 response is associated with progressive fibrosis.
authors.affiliation: Department of Medicine, Division of Pulmonary and Critical Care Medicine, The David Geffen School of Medicine at the University of California, Los Angeles 90095-1786, USA. rstrieter@mednet.ucla.edu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Strieter
authors.forename: Michael P
authors.initials: MP
authors.lastname: Keane
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D011658:Pulmonary Fibrosis / Q000276:immunology*; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: C515187:CXCR3 protein, human; C515188:Cxcr3 protein, mouse; D016207:Cytokines; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine