Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease.
Discrimination between beneficial commensal organisms and potentially harmful pathogens is a central component of the essential role that gut immune cells play in maintaining the balance between immune activation and tolerance. Antigen presenting cells (APC) are the key to this process, and the type of APC, including epithelial cells, B cells, macrophages, and dendritic cells (DC), in the gut is varied. The purpose of this review is to focus on the vast amount of data that has recently been generated on gastrointestinal dendritic cells in the context of their potential function and contribution to mucosal immunity, tolerance, and disease.
Bilsborough
Janine
J
Department of Autoimmunity and Vascular Biology, Amgen, Seattle, Washington, USA.
Viney
Joanne L
JL
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D003092:Colitis / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D023421:Models, Animal; D011956:Receptors, Cell Surface / Q000276:immunology; D019707:Receptors, Chemokine / Q000276:immunology; D051193:Toll-Like Receptors
D015703:Antigens, CD; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D019707:Receptors, Chemokine; D051193:Toll-Like Receptors