Evolution of vaccinia virus-specific CD8+ cytotoxic T-lymphocyte responses in primary vaccinees and revaccinees.
Determination of successful vaccination with vaccinia virus is based on visual confirmation of a dermal response (take). Some revaccinees do not manifest a take, which may be due to a preexisting immunity rather than to poor technique or inadequate virus. Cytotoxic T-lymphocyte (CTL) response appears to be the most important immune defense in limiting response to vaccination. We evaluated vaccinia virus-specific CTL responses in revaccinees. Subjects with and without takes displayed comparable CTL responses. Vaccinia virus-specific CD8+ CTL responses may be useful in interpreting the response to vaccination, particularly in individuals who are revaccinated and have difficult-to-interpret visual takes.
Tenorio
Allan R
AR
Section of Infectious Diseases, Department of Medicine, Rush Medical College, Chicago, Illinois 60613, USA. allan_s_tenorio@rush.edu
Peeples
Mark E
ME
Patri
Manokiran
M
Rezai
Katayoun
K
Trenholme
Gordon M
GM
D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000821:virology; D014611:Vaccination; D014616:Vaccinia virus / Q000276:immunology*
D007371:Interferon-gamma