Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective study.
Anti-basal ganglia antibodies (ABGA) are associated with movement disorders in children, but have not been assessed in adult onset movement disorders. In a prospective assessment ABGA were positive in 65% of a group of 65 patients with atypical movement disorders, but were very rare in healthy adults and adults with idiopathic dystonia. An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders.
Edwards
M J
MJ
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, UK.
Trikouli
E
E
Martino
D
D
Bozi
M
M
Dale
R C
RC
Church
A J
AJ
Schrag
A
A
Lees
A J
AJ
Quinn
N P
NP
Giovannoni
G
G
Bhatia
K P
KP
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D001479:Basal Ganglia / Q000276:immunology*; D004421:Dystonia / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000276:immunology; D008875:Middle Aged; D009069:Movement Disorders / Q000276:immunology; D011446:Prospective Studies; D020323:Tics / Q000276:immunology*
D001323:Autoantibodies