E-cadherin expression in prostate adenocarcinomas in Chinese and its pathological correlates.
BACKGROUND
We examined the E-cadherin expression in prostate adenocarcinomas in Chinese to correlate this immunohistochemical marker with histopathological features.


METHODS
Primary adenocarcinomas from 122 radical prostatectomy specimens were stained using anti-E-cadherin (HECD-1) antibody. The association of E-cadherin expression with serum prostate-specific antigen (PSA), pathological stage and Gleason score was assessed by Kendall's tau-b test.


RESULTS
Aberrant E-cadherin expression was identified in 79 tumors (64.8%). Abnormal E-cadherin expression did not correlate to serum PSA (p = 0.802), tumor stage (p = 0.684) and Gleason score (p = 0.385).


CONCLUSIONS
The frequency of aberrant E-cadherin expression was higher in prostate adenocarcinomas of Chinese as compared to that reported in Caucasians. No association with pathological stage, Gleason score and serum PSA was identified.
Hsu
Yen-Shen
YS
Division of Urology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Wang
Jyh-Seng
JS
Wu
Tony T
TT
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000368:Aged; D044466:Asian People; D015820:Cadherins / Q000096:biosynthesis*; D002681:China; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*
D015820:Cadherins