title: Kinetics of severe acute respiratory syndrome (SARS) coronavirus-specific antibodies in 271 laboratory-confirmed cases of SARS.
abstract: The sensitivities and specificities of an immunofluorescence assay and an enzyme immunoassay for detection of antibodies specific for severe acute respiratory syndrome coronavirus (SARS-CoV) were compared for 148 laboratory-confirmed SARS cases. The appearance and persistence of SARS-CoV-specific antibodies were assessed, with immunoglobulin G detected in 59% of samples collected within 14 days and persisting for 60 to 95 days after the onset of illness.
authors.affiliation: Beijing Ditan Hospital, People's Republic of China. zhongpinghe@yahoo.com
authors.forename: Zhongping
authors.initials: Z
authors.lastname: He
authors.forename: Qingming
authors.initials: Q
authors.lastname: Dong
authors.forename: Hui
authors.initials: H
authors.lastname: Zhuang
authors.forename: Shujing
authors.initials: S
authors.lastname: Song
authors.forename: Guoai
authors.initials: G
authors.lastname: Peng
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Luo
authors.forename: Dominic E
authors.initials: DE
authors.lastname: Dwyer
mesh_terms: D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007125:Immunogenetics; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007700:Kinetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D012680:Sensitivity and Specificity; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M