Acute superior mesenteric vein thrombosis associated with factor V 'Leiden' gene mutation.
OBJECTIVE
To study thrombophilia states in Indian patients with acute spontaneous superior mesenteric vein thrombosis (SMVT).


METHODS
Two men with this condition, a 56 year old and a 31 year old presenting with acute SMVT, demonstrated on CT scan, were subjected to a thrombophilia screen consisting of Protein C, S, antithrombin levels, lupus anticoagulant, anticardiolipin antibodies, fibrinogen levels, factor VIII levels, factor V 'Leiden' gene mutation, and paroxysmal nocturnal hematuria screen.


RESULTS
A thrombophilia screen showed factor V 'Leiden' gene mutation (heterozygous) in both cases. Additionally, the first patient had high fibrinogen levels and the second high factor VIII levels. Both patients are currently on long-term anticoagulation.


CONCLUSIONS
Factor V 'Leiden' gene mutation in association with other thrombophilic factors may predispose to spontaneous superior mesenteric vein thrombosis.
Shah
S R
SR
Section of GI Surgery, PD Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai 400 016, India.
Gupta
A D
AD
Sharma
A
A
Joshi
A
A
Desai
D
D
Abraham
P
P
D000208:Acute Disease; D000328:Adult; D005165:Factor V / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000235:genetics*; D008642:Mesenteric Veins; D008875:Middle Aged; D009154:Mutation; D019851:Thrombophilia / Q000235:genetics*; D020246:Venous Thrombosis / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V