Role of 5-hydroxytryptamine in Moringa oleifera induced potentiation of pentobarbitone hypnosis in albino rats.
The role of 5-hydroxytryptamine (5-HT) in pentobarbitone (PB) sleeping time, gross behaviour, electrical activity of the brain and serum 5-HT level was studied in Holtzman strain adult albino rats following treatment with M. oleifera (MO). MO (350mg/kg) caused inhibition of awareness, touch response, motor activity, righting reflex, and grip strength. It significantly increased the PB sleeping time, serum 5-HT level (P<0.001) and alpha-wave activity. These observations indicate that the aqueous extract of MO potentiated PB induced sleeping time and increased the alpha-wave activity through 5-HT.
Ray
Kausik
K
Neurophysiology Laboratory, Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata 700 009, India.
Hazra
Rimi
R
Debnath
Pratip Kr
PK
Guha
Debjani
D
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology; D006990:Hypnosis; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D012890:Sleep; D013997:Time Factors
D016166:Free Radical Scavengers; D012701:Serotonin; D010424:Pentobarbital