title: Influence of salt form and concentration on the absorption of magnesium in rat small intestine.
abstract: The influence of magnesium concentration and salt form on the absorption of this element in the rat small intestine was investigated. The following magnesium salts were studied: gluconate, fumarate, and chloride. At 1 and 5 mM concentrations absorption was most efficient from gluconate whereas at 10 mM absorption from fumrate was more efficient. Mg2+ absorption half-life (t50%) varied with salt and concentration. The Mg2+ absorption half-life for magnesium gluconate at 10 mM concentration was 42 times as long as at 1 mM concentration. The biggest area under the curve, which characterizes substance bioavailability, was observed for each of the investigated salts at 5 mM. Therefore, we may conclude that magnesium administration at 5 mM concentration would be optimal.
authors.affiliation: Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, ul. Kasztanowa 3, Sosnowiec, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Dolinska
authors.forename: F
authors.initials: F
authors.lastname: Ryszka
mesh_terms: D000818:Animals; D001682:Biological Availability; D002712:Chlorides; D005650:Fumarates; D005942:Gluconates; D006207:Half-Life; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000502:physiology*; D007421:Intestine, Small / Q000378:metabolism*; D008274:Magnesium / Q000737:chemistry* / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012492:Salts
chemical_list: D002712:Chlorides; D005650:Fumarates; D005942:Gluconates; D012492:Salts; D008274:Magnesium