title: Enhanced marrow [18F]fluorodeoxyglucose uptake related to myeloid hyperplasia in Hodgkin's lymphoma can simulate lymphoma involvement in marrow.
abstract: [18F]Fluorodeoxyglucose (FDG) positron emission tomography (PET) is increasingly used for the clinical staging of lymphomas and for assessment of response to therapy. We report the case of a woman with classic Hodgkin's lymphoma who had marked FDG uptake by tumor and bone marrow suggestive of diffuse marrow involvement by lymphoma. However, iliac crest bone marrow examination showed marked myeloid hyperplasia without evidence of lymphoma involvement. We discuss the implications for interpretation of FDG-PET imaging of bone marrow in lymphomas.
authors.affiliation: Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, 17104, USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Elstrom
authors.forename: Donald E
authors.initials: DE
authors.lastname: Tsai
authors.forename: Jo-Anne
authors.initials: JA
authors.lastname: Vergilio
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Downs
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Schuster
mesh_terms: D001692:Biological Transport; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18