The evolution of omentum transposition: from lymphedema to spinal cord, stroke and Alzheimer's disease.
It is now well established that the omentum incorporates into its tissues a variety of biological factors that exert a favorable effect on the central nervous system. Physiological characteristics of the omentum include edema absorption, fibrotic inhibition, blood-brain barrier penetration and, of major importance, angiogenic activity. Over several decades, studies have shown increasing clinical uses of the omentum following its placement on various structures within the body. This paper details the evolution of omental transposition (OT) up to the present at which time OT is being applied to the brain of Alzheimer disease (AD) patients. Success in this area raises the possibility that the omentum may prove to be a present-day treatment for patients with AD until future pharmaceutical and/or genetic forms of treatment are developed.
Goldsmith
Harry S
HS
University of Nevada School of Medicine, Reno, Glenbrook, NV, USA. Hlgldsmith@aol.com
D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology; D006801:Humans; D008209:Lymphedema / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D018919:Neovascularization, Physiologic / Q000502:physiology; D009852:Omentum / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D020521:Stroke / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000379:methods* / Q000639:trends