title: L-arginine-induced experimental pancreatitis.
abstract: Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe disease. In 1984, Mizunuma et al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in rats. This non-invasive model is highly reproducible and produces selective, dose-dependent acinar cell necrosis. Not only is this a good model to study the pathomechanisms of acute necrotizing pancreatitis, but it is also excellent to observe and influence the time course changes of the disease. By writing this review we illuminate some new aspects of cell physiology and pathology of acute necrotizing pancreatitis. Unfortunately, the reviews about acute experimental pancreatitis usually did not discuss this model. Therefore, the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis.
authors.affiliation: University of Szeged, Faculty of Medicine, First Department of Medicine, PO Box 469, H-6701, Szeged, Hungary. hep@in1st.szote.u-szeged.hu
authors.forename: Péter
authors.initials: P
authors.lastname: Hegyi
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Rakonczay
authors.forename: Réka
authors.initials: R
authors.lastname: Sári
authors.forename: Csaba
authors.initials: C
authors.lastname: Góg
authors.forename: János
authors.initials: J
authors.lastname: Lonovics
authors.forename: Tamás
authors.initials: T
authors.lastname: Takács
authors.forename: László
authors.initials: L
authors.lastname: Czakó
mesh_terms: D000818:Animals; D001120:Arginine / Q000008:administration & dosage; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced* / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D012038:Regeneration
chemical_list: D001120:Arginine