Treatment of recalcitrant scleromyxedema with thalidomide in 3 patients.
Scleromyxedema is a generalized, papular, and sclerodermoid form of lichen myxedematosus associated with monoclonal gammopathy and systemic changes. Despite anecdotal reports of success with various agents, no satisfactory treatments are currently available. We report 3 adult patients with recalcitrant scleromyxedema associated with paraproteinemia who were treated with thalidomide. All 3 patients had marked improvement of the skin lesions and joint mobility after the first 2 months of therapy, with further amelioration after 4 months, and reduction in paraprotein levels.
Sansbury
Julia C
JC
Department of Dermatology and Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. jjurgens@wfubmc.edu
Cocuroccia
Barbara
B
Jorizzo
Joseph L
JL
Gubinelli
Emanuela
E
Gisondi
Paolo
P
Girolomoni
Giampiero
G
D000368:Aged; D005260:Female; D006801:Humans; D017512:Lichenoid Eruptions / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009230:Myxedema / Q000150:complications / Q000188:drug therapy; D010265:Paraproteinemias / Q000188:drug therapy / Q000209:etiology; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy*; D013792:Thalidomide / Q000627:therapeutic use*
D013792:Thalidomide