Strengths and weaknesses of established indirect models to detect recombinant human erythropoietin abuse on blood samples collected 48-hr post administration.
We studied indirect detection models of erythropoietin abuse (EPO) on blood samples collected 48-hr after administration of the drug during 6 weeks of recombinant human erythropoietin (rHuEPO) treatment. Although the efficiency of OFF-models was preserved, we found a loss of sensitivity of ON-models. This study also revealed an increased percentage of stomatocytes in athletes receiving rHuEPO
Connes
Philippe
P
Caillaud
Corinne
C
Simar
David
D
Villard
Sébastien
S
Sicart
Marie-Thérèse
MT
Audran
Michel
M
D004300:Doping in Sports; D004921:Erythropoietin / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D011994:Recombinant Proteins; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods*; D013997:Time Factors
D011994:Recombinant Proteins; D004921:Erythropoietin