title: Haemangiopericytoma of the thyroid gland in combination with Hashimoto's disease.
abstract: We present a hitherto unique case of haemangiopericytoma (HP) of the thyroid gland in a 15-year-old female patient suffering from Hashimoto's disease for several months. Since angiogenesis has been discussed to play a major role in both diseases, we examined the expression of vascular endothelial growth factor (VEGF), VEGF receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs). Most interestingly, strong expression of PDGFR alpha and beta was found in spindle-shaped tumour cells and tumour vessels in HP, while VEGF and VEGFR type I and -II were negative in these regions. In contrast, VEGF was expressed in the lymphoid infiltrate of Hashimoto's disease. Since PDGFR-beta is commonly expressed in pericytes, we suggest that the strong expression discovered in this study further supports the view that HP is derived from pericytes. The combination of HP and Hashimoto's disease is most probably a coincidental event. However, this case confirms previous reports demonstrating that in patients with Hashimoto's disease different neoplasias can occur.
authors.affiliation: Institute of Pathology, Johannes Gutenberg, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany. hansen@pathologie.klinik.uni-mainz.de.
authors.forename: T
authors.initials: T
authors.lastname: Hansen
authors.forename: A
authors.initials: A
authors.lastname: Gaumann
authors.forename: M
authors.initials: M
authors.lastname: Ghalibafian
authors.forename: A
authors.initials: A
authors.lastname: Höferlin
authors.forename: A
authors.initials: A
authors.lastname: Heintz
authors.forename: C J
authors.initials: CJ
authors.lastname: Kirkpatrick
mesh_terms: D000293:Adolescent; D005260:Female; D006393:Hemangiopericytoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009389:Neovascularization, Pathologic / Q000378:metabolism; D020286:Pericytes / Q000378:metabolism; D017479:Receptors, Platelet-Derived Growth Factor / Q000096:biosynthesis; D040262:Receptors, Vascular Endothelial Growth Factor / Q000096:biosynthesis; D013964:Thyroid Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: D042461:Vascular Endothelial Growth Factor A; D017479:Receptors, Platelet-Derived Growth Factor; D040262:Receptors, Vascular Endothelial Growth Factor