Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.
The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.
Helisalmi
S
S
Department of Neuroscience, Kuopio University Hospital and University of Kuopio, Finland.
Dermaut
B
B
Hiltunen
M
M
Mannermaa
A
A
Van den Broeck
M
M
Lehtovirta
M
M
Koivisto
A M
AM
Iivonen
S
S
Cruts
M
M
Soininen
H
H
Van Broeckhoven
C
C
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053829:Amyloid Precursor Protein Secretases; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005387:Finland / Q000453:epidemiology; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D053764:Presenilin-1; D053766:Presenilin-2
D001057:Apolipoproteins E; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; C413604:nicastrin protein; D053829:Amyloid Precursor Protein Secretases