title: Urethral 'recurrence' found 14 years after radical cystectomy.
abstract: We report a case of transitional cell urethral cancer diagnosed 14 years after radical cystectomy. Traditionally, in the postcystectomy setting, these cancers have been referred to as 'recurrences'. We review the biological models for the oncogenesis of these cancers and propose that they are typically a result of a field cancerization effect, rather than being derived from the same clone responsible for the original urothelial tumor.
authors.affiliation: Oncology Department, Marshfield Clinic-Wausau Center, Wausau Hospital, WI 54401, USA. sorscher.steven@marshfieldclinic.org
authors.forename: Steven
authors.initials: S
authors.lastname: Sorscher
authors.forename: Rezwan
authors.initials: R
authors.lastname: Islam
authors.forename: Albert
authors.initials: A
authors.lastname: Mason
mesh_terms: D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000601:surgery*; D015653:Cystectomy; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D013997:Time Factors; D014523:Urethral Neoplasms / Q000175:diagnosis*; D001749:Urinary Bladder Neoplasms / Q000601:surgery*