Clozapine treatment in oromandibular dystonia.
Oromandibular dystonia (OMD) is a form of focal dystonias, which can be associated with substantial disability and is frequently refractory to all antidystonic therapies. Clozapine is a dibenzodiazepin derivative atypical neuroleptic that has been reported to be effective in the treatment of primary or symptomatic dystonia. We report here two patients with severe OMD refractory to other antidystonic therapies, who had substantial improvement with clozapine. We suggest that clozapine should be considered in patients with OMD who fail to response to other treatments.
Hanagasi
Hasmet A
HA
Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul, Turkey. hasmet@yahoo.com
Bilgic
Basar
B
Gurvit
Hakan
H
Emre
Murat
M
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D004421:Dystonia / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008336:Mandibular Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008410:Masticatory Muscles / Q000187:drug effects / Q000503:physiopathology; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D003024:Clozapine