title: Oxidative cyclizations: the asymmetric synthesis of (-)-alliacol A.
abstract: A tandem anodic coupling-Friedel-Crafts alkylation strategy has been used to rapidly complete the asymmetric synthesis of alliacol A. The anodic oxidation reaction allowed for the generation of a new bond between two nucleophiles. In the synthesis, the absolute stereochemistry of the final natural product is set relative to a methyl group that is incorporated early in the sequence using an asymmetric Michael reaction.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.
authors.forename: John
authors.initials: J
authors.lastname: Mihelcic
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Moeller
mesh_terms: D000363:Agaricales / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D012717:Sesquiterpenes; C032955:alliacol A