Case report: combination artemether-lumefantrine and haemolytic anaemia following a malarial attack.
A case of a patient who was admitted to hospital in Paris, France, in February 2001 with autoimmune haemolytic anaemia, probably due to artemether-lumefantrine therapy, is presented. Such a complication has previously been observed in patients receiving drugs containing aryl-amino-alcohols but never before in a patient receiving lumefantrine and may be associated with the increase in episodes of blackwater fever seen in recent years.
Mérat
Stéphane
S
Department of Anaesthesiology, HIA du Valde Grâce, 74 Bd Port Royal, 75005 Paris, France. schmart@free.fr
Lambert
Evelyne
E
Vincenti-Rouquette
Isabelle
I
Gidenne
Stéphane
S
Rousseau
Jean-Marie
JM
Brinquin
Louis
L
D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D000962:Antimalarials / Q000009:adverse effects*; D000077549:Artemether; D037621:Artemisinins / Q000009:adverse effects*; D004338:Drug Combinations; D004983:Ethanolamines / Q000009:adverse effects*; D005449:Fluorenes / Q000009:adverse effects*; D006801:Humans; D000078102:Lumefantrine; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000009:adverse effects*
D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D004983:Ethanolamines; D005449:Fluorenes; D012717:Sesquiterpenes; D000077549:Artemether; D000078102:Lumefantrine