title: Biomedical application of commercial polymers and novel polyisobutylene-based thermoplastic elastomers for soft tissue replacement.
abstract: Novel polyisobutylene-based thermoplastic elastomers are introduced as prospective implant materials for soft tissue replacement and reconstruction. In comparison, poly(ethylene terephthalate) (PET), poly(tetrafluoroethylene) (PTFE), polypropylene (PP), polyurethanes (PU), and silicones are outlined from well-established implant history as being relatively inert and biocompatible biomaterials for soft tissue replacement, especially in vascular grafts and breast implants. Some general considerations for the design and development of polymers for soft tissue replacement are reviewed from the viewpoint of material science and engineering, with special attention to synthetic materials used in vascular grafts and breast implants.
authors.affiliation: Department of Chemical & Biochemical Engineering, The University of Western Ontario, London, Ontario, Canada N6A 5B9.
authors.forename: Judit E
authors.initials: JE
authors.lastname: Puskas
authors.forename: Yaohong
authors.initials: Y
authors.lastname: Chen
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D020724:Elastomers / Q000737:chemistry*; D006801:Humans; D013677:Medical Laboratory Science / Q000295:instrumentation / Q000379:methods; D010969:Plastics / Q000737:chemistry*; D011090:Polyenes / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D019736:Prostheses and Implants; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D020724:Elastomers; D010969:Plastics; D011090:Polyenes; D011108:Polymers; C008967:polyisobutylene