Synthesis of substituted thienopyrimidine-4-ones.
The parallel solution-phase synthesis of more than 3000 substituted thienopyrimidin-4-ones has been accomplished. Key reactions include assembly of the 2-thioxopyrimidin-4-one ring by condensation of isomeric aminothiophenecarboxylates or their appropriate reactive derivatives (isothiocyanates or dithiocarbamates) with the corresponding isothiocyanates or amines. The libraries from libraries were then obtained in good yields and purities using solution-phase alkylation and acylation methodologies. Simple manual techniques for parallel reactions using special CombiSyn synthesizers were coupled with easy purification procedures (crystallization from the reaction mixtures) to give high-purity final products. The scope and limitations of the developed approach are discussed.
Ivachtchenko
Alexandre
A
Chemical Diversity Labs, Inc., 11558 Sorrento Valley Road, Suite 5, San Diego, California 92121, USA. av@chemdiv.com
Kovalenko
Sergiy
S
Tkachenko
Olena V
OV
Parkhomenko
Oleksiy
O
D000478:Alkylation; D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry; D003485:Cyanates / Q000737:chemistry; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry
D000588:Amines; D000596:Amino Acids; D000928:Antidepressive Agents; D003485:Cyanates; D011743:Pyrimidines; D013438:Sulfhydryl Compounds; C476003:thienopyrimidine