Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures.
Convulsions are common complications of shigellosis in children. Corticotropin-releasing hormone (CRH), a stress neurohormone, has been implicated in the susceptibility of young children to seizures. We investigated the role of CRH in Shigella-related seizures. Pretreatment with Shigella dysenteriae sonicate enhanced mice response to pentylenetetrazole (PTZ)-induced seizures. Preinjection of antalarmin, a CRH-receptor 1 antagonist, decreased both the mean convulsion score (MCS: 1.6 vs. 1.1, p<0.05) and the percent of mice having seizures (48% vs. 28%, p=0.03). This indicates that CRH plays a role in the increased susceptibility to seizures following exposure to S. dysenteriae.
Yuhas
Yael
Y
Laboratory of Infectious Diseases, Felsenstein Medical Research Center, Petach Tikva, Israel. yuhas@post.tau.ac.il
Weizman
Abraham
A
Chrousos
George P
GP
Ovadia
Hilla
H
Ashkenazi
Shai
S
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism* / Q000502:physiology; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole; D011743:Pyrimidines / Q000627:therapeutic use; D011758:Pyrroles / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000382:microbiology* / Q000517:prevention & control; D012760:Shigella; D013997:Time Factors
D011743:Pyrimidines; D011758:Pyrroles; C103016:antalarmin; D003346:Corticotropin-Releasing Hormone; D010433:Pentylenetetrazole