title: Splenopancreatic field abnormality is not unique to trisomy 13.
abstract: Splenopancreatic fusion is an uncommon finding, usually only seen as part of the splenopancreatic field abnormality associated with trisomy 13. It may present itself either as ectopic splenic tissue in the cauda pancreatis, as ectopic pancreatic tissue in the spleen or accessory spleen, or as fusion of the cauda pancreatis and splenic hilum. In this study, we report four unrelated congenital anomaly cases presenting trisomy 21, osteocraniostenosis syndrome, isolated congenital heart defect, and oligohydramnios sequence due to prune belly syndrome, in which fusion was observed. This demonstrates that, although it may be more common in trisomy 13, this phenomenon should not be interpreted as pathognomonic to that syndrome.
authors.affiliation: Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, SP 14049-900, Brazil. lcperes@fmrp.usp.br
authors.forename: Luiz Cesar
authors.initials: LC
authors.lastname: Peres
authors.forename: Gustavo Henrique T de Sales
authors.initials: GH
authors.lastname: Barbosa
authors.forename: Renata Scarpat
authors.initials: RS
authors.lastname: Careta
authors.forename: Cristiane Miziara
authors.initials: CM
authors.lastname: Nassif
authors.forename: João Monteiro
authors.initials: JM
authors.lastname: de Pina-Neto
authors.forename: Liane R
authors.initials: LR
authors.lastname: Giuliani
authors.forename: Ciro Dresch
authors.initials: CD
authors.lastname: Martinhago
authors.forename: Israel
authors.initials: I
authors.lastname: Gomy
mesh_terms: D002882:Chromosomes, Human, Pair 13; D004314:Down Syndrome; D005260:Female; D005313:Fetal Death; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010179:Pancreas / Q000002:abnormalities* / Q000473:pathology; D013154:Spleen / Q000002:abnormalities* / Q000473:pathology; D014314:Trisomy