Evaluation of sedative and anticonvulsant activities of Unmadnashak Ghrita.
'Unmadnashak Ghrita' (UG) is a ayurvedic formulation containing Ferula narthex (6 g), Gardenia gummifera (6 g), Ellataria cardamom (6 g), Bacopa monneri (6 g), and cow's ghee (clarified butter fat) (76 g). In the present study, neuropharmacological activities of UG were evaluated for its gross behavioural effect, pentobarbitone sleeping time, spontaneous locomotor activity, antagonism to amphetamine induced hyperlocomotor activity, analgesic activity by tail flick test, rota-rod performance (motor coordination test), maximal electroshock (MES) induced seizures, and pentylenetetrazol (PTZ) induced convulsions in mice. The formulation showed CNS-depressant activity in gross behavioural test, potentiated pentobarbitone sleeping time and there was significant decrease in spontaneous locomotor count in mice. The formulation also antagonized the behavioral effects of CNS-stimulant drug amphetamine, and showed analgesic effect in mice. UG failed to affect the motor coordination test. The formulation also protected mice from MES and PTZ induced convulsions. These results suggest that UG has CNS-depressant and anticonvulsant activity in mice.
Achliya
Girish S
GS
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, 440033, India. achliya@yahoo.com
Wadodkar
Sudhir G
SG
Dorle
Avinash K
AK
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; C496346:Unmadnashak Ghrita