Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection.
We show that Ugandan adults coinfected with Schistosoma mansoni and human immunodeficiency virus type 1 (HIV-1) are able to mount S. mansoni-specific immune responses but that few such responses increase after treatment with praziquantel (PZQ). Levels of soluble worm antigen (SWA)-specific immunoglobulin (Ig) G1, IgG2, IgG3, IgG4, interleukin (IL)-4, and IL-5 increased significantly in HIV-negative participants after treatment with PZQ, whereas most soluble egg antigen-specific antibody responses and levels of interferon- gamma were unaltered. Only levels of SWA-specific IL-5 increased in HIV-1-coinfected participants after treatment. These deficiencies in immune responses may account for the previously reported increased susceptibility to infection and reinfection with S. mansoni in individuals coinfected with HIV-1.
Joseph
Sarah
S
Department of Pathology, University of Cambridge, Cambridge, United Kingdom. sj122@cam.ac.uk
Jones
Frances M
FM
Laidlaw
Maureen E
ME
Mohamed
Gamal
G
Mawa
Patrice A
PA
Namujju
Proscovia B
PB
Kizza
Moses
M
Watera
Christine
C
Whitworth
James A G
JA
Dunne
David W
DW
Elliott
Alison M
AM
D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology; D016207:Cytokines / Q000378:metabolism*; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D014454:Uganda
D000871:Anthelmintics; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D016207:Cytokines; D011223:Praziquantel