Oxidative stress to dopaminergic neurons as models of Parkinson's disease.
The effects of exogenous toxins (MPP(+), rotenone) and potentially neurotoxic properties of levodopa (L-DOPA) on the survival rate of dopaminergic neurons in dissociated primary culture are presented. Dopamine agonists show a capacity to counteract MPP(+)-toxicity. Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q(10) (CoQ(10)) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP(+) is demonstrated.
Gille
G
G
Institute of Medical Chemistry, Veterinary University of Vienna, Veterinärplatz 1, A-1210 Vienna, Austria.
Hung
S-T
ST
Reichmann
H
H
Rausch
W-D
WD
D000818:Animals; D003067:Coenzymes; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000502:physiology*; D009498:Neurotoxins / Q000633:toxicity; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000201:enzymology / Q000503:physiopathology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D003067:Coenzymes; D018491:Dopamine Agonists; D009498:Neurotoxins; D014451:Ubiquinone; D014446:Tyrosine 3-Monooxygenase; C024989:coenzyme Q10; D004298:Dopamine