title: Exercise training improves cardiac function postinfarction: special emphasis on recent controversies on na+/ca2+ exchanger.
abstract: Exercise training instituted after myocardial infarction improves many steps involved in cardiac excitation-contraction coupling. Focusing on Na/Caexchange, current controversies regarding whether it mediates Cainflux during an action potential, whether it is increased or decreased in disease models, whether protein kinase A alters its activity, and whether exercise training affects its function are reviewed. Finally, a novel target for exercise training in the heart is suggested.
authors.affiliation: Weis Center for Research, Geisinger Medical Center, Danville, PA 17822, USA. jcheung@geisinger.edu
authors.forename: Joseph Y
authors.initials: JY
authors.lastname: Cheung
authors.forename: Jianliang
authors.initials: J
authors.lastname: Song
authors.forename: Lawrence I
authors.initials: LI
authors.lastname: Rothblum
authors.forename: Xue-Qian
authors.initials: XQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D048429:Cell Size / Q000187:drug effects; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D051381:Rats; D019831:Sodium-Calcium Exchanger / Q000378:metabolism*
chemical_list: D019831:Sodium-Calcium Exchanger; D017868:Cyclic AMP-Dependent Protein Kinases; D002118:Calcium