title: CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice.
abstract: DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.
authors.affiliation: Department of Neurology, University of Chicago, IL 60637, USA.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Lin
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Ma
authors.forename: Moses
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Roos
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D001921:Brain / Q000821:virology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D051379:Mice; D017945:Theilovirus / Q000276:immunology*