title: Monitoring of rheologic variables during postoperative high-dose brachytherapy for uterine cancer.
abstract: Oxygenation of tumor tissue has recently been assed an important prerequisite for the effectiveness of radiotherapy in cervical cancer. Hyperviscosity is a common phenomenon in malignancy and a cause of reduced oxygen transport capacity that would favour tissue hypoxia. Hemorheological variables were serially tested preoperatively, during four cycles of fractionated adjuvant IR(192) HDR after loading radiation (HDR-AL) of the vaginal vault (weekly intervals), and 6 months postoperatively in patients with cervical (n=12) and endometrial cancer (n=26). Women who were scheduled for benign tumor surgery served as controls (n=29). Preoperatively, in cervical and endometrial cancer patients, mean plasma viscosity (PV: 1.31+/-0.1 mPa s; p<0.05; 1.35+/-0.13 mPa s; p<0.001) and fibrinogen levels (383+/-46 mg/dL; p<0.05; 379+/-117 mg/dL; p<0.05) were higher as compared to the controls (1.25+/-0.07 mPa s; 314+/-89 mg/dL). Red blood cell aggregation at low shear and stasis (RBC agg.: 15.7+/-5.6; p<0.05; 29.6+/-9.1; p<0.05) was higher in endometrial cancer patients as compared to the controls (13.7+/-3.4; 25.3+/-5.6). Postoperatively PV decreased in endometrial cancer patients and transiently increased in cervical cancer patients. After the third session of irradiation in both cancer groups, PV regained and at the 6-month checkup, levels were higher as compared to the values before surgery. Postoperatively fibrinogen levels increased and remained higher throughout HDR-AL and 6 months postoperatively. After surgery and during irradiation, anemia persisted in both cancer groups while hematocrit recovered after 6 months in endometrial cancer patients. Thrombosis was diagnosed in three patients postoperatively (7.9 %) but in none during HDR-AL. While a temporary reduction of hyperviscosity is found postoperatively and during HDR-AL in uterine cancer patients, 6 months after surgery RBC aggregation, PV, and hematocrit returned to the pretreatment range.
authors.affiliation: Department of Obstetrics and Gynecology, City Hospital of Ruesselsheim, Ruesselsheim, Germany. G-F.von.Tempelhoff@gmx.de
authors.forename: Georg-Friedrich
authors.initials: GF
authors.lastname: von Tempelhoff
authors.forename: Lothar
authors.initials: L
authors.lastname: Heilmann
authors.forename: Kunhard
authors.initials: K
authors.lastname: Pollow
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hommel
mesh_terms: D000368:Aged; D015415:Biomarkers; D001809:Blood Viscosity; D001918:Brachytherapy; D015687:Cell Hypoxia / Q000528:radiation effects; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000097:blood* / Q000532:radiotherapy / Q000601:surgery; D004903:Erythrocyte Aggregation; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007044:Hysterectomy; D007958:Leukocyte Count; D008875:Middle Aged; D010976:Platelet Count; D018714:Radiotherapy, Adjuvant; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000532:radiotherapy / Q000601:surgery
chemical_list: D015415:Biomarkers; D005340:Fibrinogen