APC I1307K and the E1317Q variants are not present in Chinese colorectal cancer patients.
OBJECTIVE
The APC I1307K and E1317Q variants predispose to colorectal adenomas and carcinomas in Caucasians, but data are lacking in Asians.


RESULTS
We sequenced the APC gene from codons 1261 to 1409 and found none of 147 Chinese, 20 Malay, and 11 Indian colorectal cancer patients in Singapore to carry the APC I1307K or E1317Q variants.


CONCLUSIONS
These variants are rare in these Asian populations, and play little role in colorectal cancer causation in Chinese.
Guo
Jiayi
J
Departments of Haematology-Oncology and Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore.
Lim
Robert
R
Soo
Ross
R
Leong
Adrian
A
Lee
Soo Chin
SC
D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics*
D025601:Adenomatous Polyposis Coli Protein