Shedding of human herpesvirus 8 in oral and genital secretions from HIV-1-seropositive and -seronegative Kenyan women.
Polymerase chain reaction was used to determine the prevalence and correlates of human herpesvirus 8 (HHV8) in saliva, mouth, cervical, vaginal, plasma, and peripheral-blood mononuclear cell (PBMC) samples from 174 HHV8-seropositive female prostitutes in Mombasa, Kenya. The prevalence of detection of HHV8 was 32% in saliva samples, 28% in mouth swabs, 4% in cervical swabs, 2.3% in vaginal swabs, 9% in plasma samples, and 18% in PBMC samples. Human immunodeficiency virus type 1 (HIV-1) seropositivity was associated with detection of HHV8 from any mucosal surface (odds ratio, 2.1 [95% confidence interval, 1.1-4.0]). In HIV-1-seropositive women, there was no association between detection of HHV8 and either CD4 count or HIV-1 viral load.
Taylor
Melanie M
MM
Department of Medicine, University of Washington, Seattle, Washington, USA. metaylor@dhs.co.la.ca.us
Chohan
Bhavna
B
Lavreys
Ludo
L
Hassan
Wisal
W
Huang
Meei-Li
ML
Corey
Larry
L
Ashley Morrow
Rhoda
R
Richardson
Barbra A
BA
Mandaliya
Kishorchandra
K
Ndinya-Achola
Jeckoniah
J
Bwayo
Job
J
Kreiss
Joan
J
D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000821:virology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000097:blood; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism / Q000821:virology*; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D007963:Leukocytes, Mononuclear / Q000821:virology; D009055:Mouth / Q000378:metabolism / Q000821:virology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012463:Saliva / Q000821:virology; D012514:Sarcoma, Kaposi / Q000150:complications / Q000821:virology; D011477:Sex Work; D014621:Vagina / Q000821:virology; D017201:Virus Shedding
D004279:DNA, Viral