Treatment of severe Clonorchiasis sinensis by endoscopic nasobiliary drainage and oral praziquantel.
OBJECTIVE
To assess the therapeutic value of endoscopic nasobiliary drainage (ENBD) and oral praziquantel for severe Clonorchiasis sinensis infection.


METHODS
Of the 84 Clonorchiasis sinensis-infected patients enrolled, 58 were treated with ENBD (as observing group, ENBD group), 26 received operations (control group, operation group). Both of the two groups were comparable in terms of patient's age, body mass index. Before and one week after treatment, the average diameters of common bile ducts were measured by ultrasound, and serum bilirubin, ALP, gamma-GT and ALT were detected by biochemical methods. After ENBD or operation, the patients took praziquantel for two days.


RESULTS
Compared with the patients in operation group, ENBD patients in ENBD group had higher recovery rates of abdominal pain and fever as well as jaundice, quicker remission, smaller trauma, fewer complications and lower cost.


CONCLUSIONS
ENBD combined with oral praziquantel is an effective and safe method for the treatment of severe Clonorchiasis sinensis.
Zhi
Fa-Chao
FC
PLA Institute for Digestive Medicine, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong Province, China. zfc@fimmu.com
Liu
Xu-Ming
XM
Liu
Ze-Quan
ZQ
Lin
Yan
Y
Chen
Shu-Jian
SJ
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000871:Anthelmintics / Q000008:administration & dosage*; D001652:Bile Ducts; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003003:Clonorchiasis / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D004322:Drainage; D004384:Duodenoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D011223:Praziquantel / Q000008:administration & dosage*; D012720:Severity of Illness Index
D000871:Anthelmintics; D011223:Praziquantel