Influence of aluminium on neurotoxicity of lead in adult male albino rats.
Influence of aluminium on neurotoxicity of lead was studied in male albino rats. Aluminium enhanced the net deposition of lead in brain. This was further substantiated by higher levels of malondialdehyde (MDA), and lower activities of acetylcholinesterase enzyme in the brain homogenates of the rats treated with both lead and aluminium as compared to those of rats treated with lead only. In lead plus aluminium treated animals, a significant neurological deficit was observed when the animals were subjected to rota-rod, traction performance (TP) and tail immersion tests.
Shakoor
A
A
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar 243 122, India.
Gupta
P K
PK
Kataria
M
M
D000110:Acetylcholinesterase / Q000378:metabolism; D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001933:Brain Stem / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011930:Reaction Time
D008315:Malondialdehyde; D000535:Aluminum; D000110:Acetylcholinesterase