title: Characterization of a polyvinyl alcohol-hydrogel artificial articular cartilage prepared by injection molding.
abstract: We have developed a hip hemi-arthroplasty using polyvinyl alcohol-hydrogel (PVA-H) as the treatment for hip joint disorders in which the lesion is limited to the joint surface. In previous studies, we characterized the biocompatibility and the mechanical properties of PVA-H as an arthroplasty material. To fix PVA-H firmly to the bone, we have devised an implant composed of PVA-H and porous titanium fiber mesh (TFM). However, because of poor infiltration of the PVA solution into the pores of the TFM when using the low temperature crystallization method, the strength of the PVA-H-TFM interface was insufficient. Consequently, the infiltration method was improved by adopting high-pressure injection molding. With this improved method, the bonding strength of the interface increased remarkably. However, as this injection molding requires high temperature, various mechanical properties of the PVA-H might change with this treatment in comparison with the previous method. The purpose of this study was to investigate the effect of high temperature treatment on the mechanical properties of PVA-H as artificial articular cartilage, the tensile test and friction test were performed about new PVA-H. The results showed no significant mechanical deterioration of the PVA-H. This certified that the injection-molding method did not induce the change of the mechanical properties of PVA-H and indicated the potential of hemi-arthroplasty using PVA-H by this method in the future.
authors.affiliation: Orthopaedic Research Department, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. m-bear@rf7.so-net.ne.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Masanori
authors.initials: M
authors.lastname: Oka
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000818:Animals; D001178:Arthroplasty / Q000379:methods; D001672:Biocompatible Materials / Q000737:chemistry*; D002356:Cartilage / Q000737:chemistry; D002358:Cartilage, Articular / Q000737:chemistry*; D004285:Dogs; D008422:Materials Testing; D010003:Osteoarthritis / Q000628:therapy; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011312:Pressure; D013314:Stress, Mechanical; D013696:Temperature; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry
chemical_list: D000438:Alcohols; D001672:Biocompatible Materials; C062364:polyvinyl alcohol hydrogel; D011142:Polyvinyl Alcohol; D014025:Titanium