title: (E)- and (Z)-1,2,4-triazolylchromanone oxime ethers as conformationally constrained antifungals.
abstract: A series of 1,2,4-triazolylchromanone oxime ethers were synthesized and tested for in vitro antifungal activity. Many of these derivatives exhibit high activity against Candida albicans, Saccharomyces cerevisiae, Aspergillus niger and Microsporum gypseum.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, PO Box 48175-861, Sari, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Emami
authors.forename: Mehraban
authors.initials: M
authors.lastname: Falahati
authors.forename: Ali
authors.initials: A
authors.lastname: Banifatemi
authors.forename: Massoud
authors.initials: M
authors.lastname: Amanlou
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002839:Chromans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D015394:Molecular Structure; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D002839:Chromans; D004987:Ethers; D010091:Oximes