title: Normal values for CD4 and CD8 lymphocyte subsets in healthy Chinese adults from Shanghai.
abstract: The aim of this study was to establish reference ranges for lymphocyte subsets in Chinese adults. Venous blood specimens were obtained from 614 healthy, human immunodeficiency virus (HIV)-seronegative adults in Shanghai. Flow cytometry was used to determine percentages and absolute numbers of CD4 and CD8 T lymphocytes. Mean values for CD4 and CD8 lymphocytes were 727 and 540 cells/microl, respectively, yielding a CD4/CD8 ratio of 1.49. While CD8 lymphocyte values varied with age and gender, no significant differences in CD4 lymphocyte values were observed. Shanghai adults had approximately 100 fewer CD4 lymphocytes/microl on average than Caucasians, suggesting that lower CD4 lymphocyte cutoffs for classifying and monitoring HIV infection may be needed in China.
authors.affiliation: Department of Infectious Diseases, Fudan University Huashan Hospital, Shanghai, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: Jiang
authors.forename: Laiyi
authors.initials: L
authors.lastname: Kang
authors.forename: Hong-Zhou
authors.initials: HZ
authors.lastname: Lu
authors.forename: Xiaozhang
authors.initials: X
authors.lastname: Pan
authors.forename: Qingneng
authors.initials: Q
authors.lastname: Lin
authors.forename: Qichao
authors.initials: Q
authors.lastname: Pan
authors.forename: Yile
authors.initials: Y
authors.lastname: Xue
authors.forename: Xinhua
authors.initials: X
authors.lastname: Weng
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People / Q000208:ethnology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002681:China / Q000208:ethnology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018655:Lymphocyte Count / Q000592:standards*; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D044465:White People / Q000208:ethnology