title: A comparative prospective study of two available solutions for kidney and liver preservation.
abstract: BACKGROUND
  Viaspan (University of Wisconsin [UW]) solution is the gold standard for abdominal organ preservation. Celsior (CEL) is an extracellular-type, low-potassium, low-viscosity solution, initially used for heart and lung preservation. We have performed a prospective multicenter study to compare the role of these cold-storage solutions on kidney and liver recovery after transplantation.
  
  
  METHODS
  From March 15, 2000 to December 31, 2001, 441 (172 CEL and 269 UW) renal transplants (RT) and 175 (79 CEL and 96 UW) liver transplants (LT) were included in the study.
  
  
  RESULTS
  Perfusate volume used was significantly lower in the UW group, being 4,732 +/- 796 mL versus 5,826 + 834 mL in the CEL group (P < 0.001). In LT, median total bilirubin serum levels were significantly higher at 5 and 7 posttransplant days in the UW group (90.6 and 92.3 micromol/L, respectively) as compared with CEL (51.3 and 63.4 micromol/L, respectively). After LT, primary nonfunction (PNF) rates in the CEL and UW groups were 3.8% and 4.2% (P = NS) respectively, with 1-year graft and patient survival being 83.3% versus 85.4% (P = NS) and 89.9% versus 90.6% (P = NS). After RT, delayed graft function (DGF) rates were 23.2% and 22.7% (P = NS), respectively; PNF rates were 1.9% and 1.7% (P = NS) respectively, with 1-year graft and patient survival being 92.3% versus 94.2% (P = NS) and 99.4% versus 97.7% (P = NS).
  
  
  CONCLUSIONS
  CEL solution was shown to be as effective as UW in both liver and kidney preservation. In LT patients, biliary function recovery is significantly better in the CEL group. CEL solution represents an efficacious option in multiorgan harvesting.
authors.affiliation: Genetic and Molecular Epidemiology Unit-IRCCS Ospedale Maggiore, Milano, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Pedotti
authors.forename: Massimo
authors.initials: M
authors.lastname: Cardillo
authors.forename: Paolo
authors.initials: P
authors.lastname: Rigotti
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gerunda
authors.forename: Roberto
authors.initials: R
authors.lastname: Merenda
authors.forename: Umberto
authors.initials: U
authors.lastname: Cillo
authors.forename: Giacomo
authors.initials: G
authors.lastname: Zanus
authors.forename: Umberto
authors.initials: U
authors.lastname: Baccarani
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Berardinelli
authors.forename: Luigi
authors.initials: L
authors.lastname: Boschiero
authors.forename: Lucio
authors.initials: L
authors.lastname: Caccamo
authors.forename: Gilberto
authors.initials: G
authors.lastname: Calconi
authors.forename: Stefano
authors.initials: S
authors.lastname: Chiaramonte
authors.forename: Antonio
authors.initials: A
authors.lastname: Dal Canton
authors.forename: Luciano
authors.initials: L
authors.lastname: De Carlis
authors.forename: Valerio
authors.initials: V
authors.lastname: Di Carlo
authors.forename: Donato
authors.initials: D
authors.lastname: Donati
authors.forename: Domenico
authors.initials: D
authors.lastname: Montanaro
authors.forename: Andrea
authors.initials: A
authors.lastname: Pulvirenti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Remuzzi
authors.forename: Silvio
authors.initials: S
authors.lastname: Sandrini
authors.forename: Umberto
authors.initials: U
authors.lastname: Valente
authors.forename: Mario
authors.initials: M
authors.lastname: Scalamogna
mesh_terms: D000241:Adenosine; D000328:Adult; D000493:Allopurinol; D001663:Bilirubin / Q000097:blood; D015331:Cohort Studies; D015925:Cryopreservation; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D005978:Glutathione; D006085:Graft Survival; D006639:Histidine; D006801:Humans; D007328:Insulin; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation; D008099:Liver / Q000503:physiopathology; D016031:Liver Transplantation; D008353:Mannitol; D008875:Middle Aged; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011446:Prospective Studies; D011887:Raffinose; D016019:Survival Analysis
chemical_list: C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose; D001663:Bilirubin