title: Serum pepsinogens as a predicator of the topography of intestinal metaplasia in patients with atrophic gastritis.
abstract: The importance of atrophic gastritis with intestinal metaplasia is related to the fact that it increases the risk of gastric cancer development. The aim of this study is to evaluate the diagnostic potential of serum pepsinogens in predicting the topography of intestinal metaplasia. Both dye endoscopy and 13C-urea breath test were carried out in 878 subjects. Serum pepsinogen I, pepsinogen II, and IgG antibody to Helicobacter pylori were measured. The overall prevalence of intestinal metaplasia was higher in subjects with lower PG I/II ratios and lower PG I values. Based on ROC curves, a cutoff value for pepsinogen I/II ratio of less than 3.0 would have identified intestinal metaplasia with a sensitivity of 71.7% and a specificity of 66.7% in Helicobacter pylori-positive subjects. It is possible that serum pepsinogens could be used as a screening test for high-risk subjects with intestinal metaplasia.
authors.affiliation: Department of Gastroenterology and Hepatology, Toho University School of Medicine, Tokyo, Japan. foo@eb.mbn.or.jp
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Urita
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hike
authors.forename: Naotaka
authors.initials: N
authors.lastname: Torii
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Eiko
authors.initials: E
authors.lastname: Kanda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sasajima
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Miki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008403:Mass Screening; D008679:Metaplasia / Q000097:blood / Q000175:diagnosis; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*; D011237:Predictive Value of Tests
chemical_list: D010435:Pepsinogens