p53--an examination of sibling support in apoptosis control.
While p53 family members have distinct nonoverlapping functions, the involvement of p63 and p73 in p53-mediated apoptosis is controversial. Results of a recent study indicate that at least in thymocytes, p53-dependent apoptosis occurs independently of p63 and p73.
Benchimol
Samuel
S
Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. benchimo@uhnres.utoronto.ca
D000818:Animals; D017209:Apoptosis; D004268:DNA-Binding Proteins / Q000502:physiology; D016147:Genes, Tumor Suppressor; D051379:Mice; D009687:Nuclear Proteins / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*; D025521:Tumor Suppressor Proteins
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; C486419:Trp63 protein, mouse; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins