title: Outbreak of mumps in a vaccinated child population: a question of vaccine failure?
abstract: In Belgium, children are immunized against measles-mumps-rubella (MMR) in a two-dose schedule at the age of 15 months and 11 years. Despite these recommendations, epidemics of mumps still occur. During an outbreak of mumps in Bruges (Belgium), 105 cases were registered in seven schools (age group 3-12 years). Lower than optimal vaccination coverage, inadequate vaccination schedule and a combination of primary and/or secondary vaccine failure are considered as possible reasons for the outbreak as described in the article. The role of secondary vaccine failure is highlighted.
authors.affiliation: Department of Youth Health Care, Katholieke Universiteit Leuven, Kapucijnenvoer 35/1, 3000, Belgium. corinne.vandermeulen@med.kuleuven.ac.be
authors.forename: Corinne
authors.initials: C
authors.lastname: Vandermeulen
authors.forename: Mathieu
authors.initials: M
authors.lastname: Roelants
authors.forename: Marijke
authors.initials: M
authors.lastname: Vermoere
authors.forename: Katelijn
authors.initials: K
authors.lastname: Roseeuw
authors.forename: Patrick
authors.initials: P
authors.lastname: Goubau
authors.forename: Karel
authors.initials: K
authors.lastname: Hoppenbrouwers
mesh_terms: D001530:Belgium; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D032541:Mass Vaccination; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology; D009107:Mumps / Q000453:epidemiology*; D009108:Mumps Vaccine / Q000276:immunology*; D016017:Odds Ratio; D017211:Treatment Failure
chemical_list: D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine