Epithelium-mesenchyme: a balancing act of RhoGAP and RhoGEF.
Transitions between epithelium and mesenchyme, in either direction, contribute repeatedly to animal development. Three striking papers suggest that distinct components with opposite activities, which together form a complex known for its role in cytokinesis, control these opposite transitions.
Labouesse
Michel
M
IGBMC, 1 rue Laurent Fries, BP10142, 67404 Illkirch, France. lmichel@igbmc.u-strasbg.fr
D022005:Adherens Junctions / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D004330:Drosophila / Q000196:embryology* / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D004848:Epithelium / Q000196:embryology; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D016547:Kinesins / Q000378:metabolism; D008648:Mesoderm / Q000166:cytology; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D064067:Rho Guanine Nucleotide Exchange Factors; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; C121865:Pbl protein, Drosophila; D064067:Rho Guanine Nucleotide Exchange Factors; C114455:ZEN-4 protein, C elegans; C085379:rho GTPase-activating protein; D016547:Kinesins; D020741:rho GTP-Binding Proteins