Fast acquisition-weighted three-dimensional proton MR spectroscopic imaging of the human prostate.
The clinical application of 3D proton spectroscopic imaging (3D SI) of the human prostate requires a robust suppression of periprostatic lipid signal contamination, minimal intervoxel signal contamination, and the shortest possible measurement time. In this work, a weighted elliptical sampling of k-space, combined with k-space filtering and pulse repetition time (TR) reduction minimized lipid signals, intervoxel contamination, and measurement time. At 1.5 T, the MR-visible prostate metabolites citrate, creatine, and choline can now be mapped over the entire human prostate with uncontaminated spherical voxels, with a volume down to 0.37 cm3, in measurement times of 7-15 min.
Scheenen
Tom W J
TW
Department of Radiology, University Medical Center Nijmegen, Nijmegen, The Netherlands. T.Scheenen@rad.umcn.nl
Klomp
Dennis W J
DW
Röll
Stefan A
SA
Fütterer
Jurgen J
JJ
Barentsz
Jelle O
JO
Heerschap
Arend
A
D000328:Adult; D006801:Humans; D021621:Imaging, Three-Dimensional; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*