Lung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong.
OBJECTIVE
To study the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese.


METHODS
229 consecutive incident patients with a histological diagnosis of lung cancer from a regional hospital and 197 healthy population-based controls were recruited for this study between July 1999 and June 2001. Genetic polymorphisms of GSTT1 and GSTM1 were determined using PCR-based technique.


RESULTS
The frequencies of GSTT1 and GSTM1 null genotypes were 51.8 and 59.4% in healthy controls and 63 and 54.7%, respectively, in lung cancer patients. GSTP1 Val105/Val105 genotype was found in only 1% of healthy controls. The risk for lung cancer with GSTT1 null genotype was significantly higher, adjusted odds ratio (OR) 1.69, 95% confidence interval (CI) 1.12-2.56, compared with those with the GSTT1 genotype; the increase in risk was found only in non-smokers. GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer.


CONCLUSIONS
GSTT1 null genotype is associated with an increased risk for lung cancer in non-smoking Chinese in Hong Kong.
Chan-Yeung
Moira
M
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, SAR, PR China. mmwchan@hkucc.hku.hk
Tan-Un
Kian Cheng
KC
Ip
Mary Sau Man
MS
Tsang
Kenneth Wah Tak
KW
Ho
Siu Pang
SP
Ho
James Chung Man
JC
Chan
Henry
H
Lam
Wah Kit
WK
D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011336:Probability; D011379:Prognosis; D018570:Risk Assessment; D012907:Smoking / Q000009:adverse effects
D005982:Glutathione Transferase