Therapeutic potential of vitamin D-binding protein.
Vitamin D-binding protein (DBP) is a multi-functional plasma protein with many important functions. These include transport of vitamin D metabolites, control of bone development, binding of fatty acids, sequestration of actin and a range of less-defined roles in modulating immune and inflammatory responses. Exploitation of the unique properties of DBP could enable the development of important therapeutic agents for the treatment of a variety of diseases.
Gomme
Peter T
PT
Research and Development, CSL Limited, Bioplasma Division, 189-209 Camp Road, Broadmeadows, Victoria 3047, Australia.
Bertolini
Joseph
J
D000199:Actins / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy*; D008262:Macrophage Activation / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy*; D010022:Osteopetrosis / Q000188:drug therapy*; D011485:Protein Binding; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D014809:Vitamin D-Binding Protein / Q000737:chemistry / Q000276:immunology / Q000378:metabolism* / Q000627:therapeutic use*
D000199:Actins; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D007155:Immunologic Factors; D014809:Vitamin D-Binding Protein