title: Comparison of neointimal formation in polymer-free paclitaxel stents versus stainless stents (from the ASPECT and ELUTES randomized clinical trials).
abstract: The investigators examined 326 pairs of angiograms from 2 randomized dose-finding (0.2 to 3.1 microg paclitaxel/mm(2) of stent surface area) clinical trials of polymer-free paclitaxel-eluting stents in de novo lesions (the ASian Paclitaxel-Eluting stent Clinical Trial [ASPECT] and the European evaLUation of Taxol Eluting Stent [ELUTES]). A dose-dependent effect was observed: the largest dose of paclitaxel in the 2 trials resulted in a significantly larger proportion of lesions at follow-up with <10% diameter stenosis (54% vs 16%, p = 0.00012 in ASPECT; 53% vs 21%, p = 0.013 in ELUTES) and with minimal luminal diameter located outside the stent compared with control stents (62% vs 20% in ASPECT, 48% vs 18% in ELUTES; p <0.05). Also, significantly shorter lesion lengths at 6-month follow-up were observed for the doses of 0.7 to 3.1 microg/mm(2) (p <0.03) relative to their respective lengths before the procedure compared with control stents.
authors.affiliation: The Methodist DeBakey Heart Center and Baylor College of Medicine, Houston, Texas, USA. gkaluza@bcm.tmc.edu
authors.forename: Grzegorz L
authors.initials: GL
authors.lastname: Kałuza
authors.forename: Anthony H
authors.initials: AH
authors.lastname: Gershlick
authors.forename: Seung-Jung
authors.initials: SJ
authors.lastname: Park
authors.forename: Ivan
authors.initials: I
authors.lastname: De Scheerder
authors.forename: Bernard
authors.initials: B
authors.lastname: Chevalier
authors.forename: Edoardo
authors.initials: E
authors.lastname: Camenzind
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Goy
authors.forename: Luc
authors.initials: L
authors.lastname: Missault
authors.forename: Nicolaus
authors.initials: N
authors.lastname: Reifart
authors.forename: Christiaan
authors.initials: C
authors.lastname: Vrints
authors.forename: Philip
authors.initials: P
authors.lastname: Urban
authors.forename: Won Heum
authors.initials: WH
authors.lastname: Shim
authors.forename: David Sai Wah
authors.initials: DS
authors.lastname: Ho
authors.forename: Neal E
authors.initials: NE
authors.lastname: Fearnot
authors.forename: William D
authors.initials: WD
authors.lastname: Voorhees
authors.forename: Albert E
authors.initials: AE
authors.lastname: Raizner
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006965:Hyperplasia / Q000517:prevention & control; D017239:Paclitaxel / Q000008:administration & dosage*; D011474:Prosthesis Design; D016032:Randomized Controlled Trials as Topic; D013193:Stainless Steel; D015607:Stents; D017539:Tunica Intima / Q000473:pathology*
chemical_list: D020533:Angiogenesis Inhibitors; D013193:Stainless Steel; D017239:Paclitaxel