title: Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure.
abstract: OBJECTIVE
  Except for bleeding complications, other serious adverse reactions of coumarin anticoagulants such as hepatotoxicity or skin necrosis are comparatively rare. Nonetheless, a small number of coumarin-induced (sub-) acute liver failures has been published.
  
  
  METHODS
  A retrospective analysis was performed of patients treated for liver disease between 1992 and 2002 at our department to evaluate the incidence, clinical findings and histopathology of coumarin-induced hepatotoxicity.
  
  
  RESULTS
  The retrospective analysis revealed eight cases of phenprocoumon-induced hepatotoxicity, including three cases of (sub-) acute liver failure which resulted in two orthotopic liver transplantations and one fatal outcome. Five patients with phenprocoumon-induced hepatitis recovered well after anticoagulation was switched to another coumarin derivate or subcutaneous low molecular weight heparin. In all patients liver injury was predominantly of an hepatitic type. In the cases of (sub-) acute liver failure massive confluent liver cell necroses were histologically present, whereas among patients without liver failure mild portal to moderate active lobular hepatitis were observed. A retrospective analysis by BfArM (German Federal Institute for Drugs and Medical Devices) revealed 4390 cases of possible phenprocoumon-related adverse reactions since 1990, 2% of which had presented with hepatitis and 0.2% with liver failure.
  
  
  CONCLUSIONS
  Phenprocoumon-induced liver disease is an uncommon complication, which can, however, cause (sub-) acute liver failure.
authors.affiliation: First Department of Internal Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany. dr_schimanski@yahoo.de
authors.forename: Carl C
authors.initials: CC
authors.lastname: Schimanski
authors.forename: Jürgen
authors.initials: J
authors.lastname: Burg
authors.forename: Markus
authors.initials: M
authors.lastname: Möhler
authors.forename: Thomas
authors.initials: T
authors.lastname: Höhler
authors.forename: Stephan
authors.initials: S
authors.lastname: Kanzler
authors.forename: Gerd
authors.initials: G
authors.lastname: Otto
authors.forename: Peter R
authors.initials: PR
authors.lastname: Galle
authors.forename: Ansgar W
authors.initials: AW
authors.lastname: Lohse
mesh_terms: D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D005858:Germany; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010644:Phenprocoumon / Q000009:adverse effects*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D000925:Anticoagulants; D010644:Phenprocoumon