Soft Listeria: actin-based propulsion of liquid drops.
We study the motion of oil drops propelled by actin polymerization in cell extracts. Drops deform and acquire a pearlike shape under the action of the elastic stresses exerted by the actin comet, a tail of cross-linked actin filaments. We solve this free boundary problem and calculate the drop shape taking into account the elasticity of the actin gel and the variation of the polymerization velocity with normal stress. The pressure balance on the liquid drop imposes a zero propulsive force if gradients in surface tension or internal pressure are not taken into account. Quantitative parameters of actin polymerization are obtained by fitting theory to experiment.
Boukellal
Hakim
H
Institut Curie, UMR 168, 26 rue d'Ulm, F-75248 Paris Cedex 05, France.
Campás
Otger
O
Joanny
Jean-François
JF
Prost
Jacques
J
Sykes
Cécile
C
D000199:Actins / Q000737:chemistry* / Q000502:physiology*; D040761:Biomimetic Materials / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003198:Computer Simulation; D008081:Liposomes / Q000737:chemistry; D008089:Listeria monocytogenes / Q000737:chemistry* / Q000502:physiology*; D008863:Microspheres; D008954:Models, Biological; D008956:Models, Chemical; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000502:physiology; D009038:Motion; D009068:Movement / Q000502:physiology; D009821:Oils / Q000737:chemistry; D013314:Stress, Mechanical; D013499:Surface Properties
D000199:Actins; D020099:Coated Materials, Biocompatible; D008081:Liposomes; D020409:Molecular Motor Proteins; D009821:Oils