Polymerized ion pair amphiphile vesicles with pH-sensitive transformation and controlled release property.
Ion pair amphiphiles (IPA) composed of one proton-deionizable single or double alkyl chain ammonium surfactant and one anionic carboxylate surfactant with polymerizable dithiolane ring are prepared to develop polymerized microcapsules that can recognize pH change and transform itself under basic condition, thus releasing encapsulated materials at the desired point. Combination of pH-sensitivity and polymeric solid structure, if fully developed, endows the IPA vesicle with smart function that is highly valuable in drug delivery application. Reasons for such high pH-sensitive vesicle transformation are sought from combined physical properties such as turbidity, zeta potential, surface tension, and release rate of marker through the vesicle membrane.
Chung
Myung-Hoon
MH
Department of Chemistry, The University of Suwon, Suwon 445-743, South Korea.
Park
Chul
C
Chul Chun
Byoung
B
Chung
Yong-Chan
YC
D006863:Hydrogen-Ion Concentration; D007477:Ions; D008854:Microscopy, Electron; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry; D011522:Protons; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors
D007477:Ions; D011108:Polymers; D011522:Protons; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents