title: Comprehensive lifestyle modification and blood pressure control: a review of the PREMIER trial.
abstract: The PREMIER trial assessed the aggregate effect on blood pressure (BP) of nationally recommended lifestyle modifications in free-living adults with high-normal (stage 1) hypertension. Participants (N=810) were randomized to the advice-only group; the established group (consisting of weight loss, increased physical activity, and reduced sodium and alcohol intake); or the established plus Dietary Approaches to Stop Hypertension (DASH) diet group (consisting of the established interventions in addition to the DASH dietary pattern). The primary outcome was change in systolic BP at 6 months. Net of advice only, mean systolic BP declined by 3.7 mm Hg for members of the established group (p<0.001) and 4.3 mm Hg for the established plus DASH group (p<0.001). The prevalence of hypertension decreased from a baseline of 38% to 17% in the established group (p=0.01) and to 12% in the established plus DASH group (p<0.001) compared with a decrease to 26% in the advice-only group. The PREMIER trial demonstrated that persons with above-optimal BP and stage 1 hypertension can make multiple lifestyle changes leading to better control of BP.
authors.affiliation: Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA. mcgui020@mc.duke.edu
authors.forename: Heather L
authors.initials: HL
authors.lastname: McGuire
authors.forename: Laura P
authors.initials: LP
authors.lastname: Svetkey
authors.forename: David W
authors.initials: DW
authors.lastname: Harsha
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Elmer
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Elmer
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Appel
authors.forename: Jamy D
authors.initials: JD
authors.lastname: Ard
mesh_terms: D001519:Behavior; D001794:Blood Pressure / Q000502:physiology*; D002986:Clinical Trials as Topic; D003376:Counseling; D004039:Diet, Sodium-Restricted; D015444:Exercise; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D040242:Risk Reduction Behavior; D016896:Treatment Outcome; D015431:Weight Loss