title: Treatment of hemiballismus with stereotactic pallidotomy. Case report and review of the literature.
abstract: Hemiballismus is a relatively rare movement disorder that is characterized by uncontrolled, random, large-amplitude movements of the limbs. It is usually caused by a vascular lesion that involves the contralateral subthalamic nucleus (STN) (also known as the nucleus hypothalamicus or corpus luysi) and its afferent and efferent pathways. The authors present a case of medically intractable hemiballismus in a 70-year-old woman who was successfully treated with stereotactic posteroventral pallidotomy. In agreement with the data reported earlier by other groups, the microrecording performed during the pallidotomy showed a decreased rate of firing of the pallidal neurons, supporting the theory of impaired excitatory input from the STN to the internal part of the globus pallidus. Stereotactic pallidotomy may be the procedure of choice in the treatment of medically intractable hemiballismus. Intraoperative microrecording significantly improves the precision of the stereotactic targeting and should be considered a standard part of the pallidotomy protocol.
authors.affiliation: Department of Neurological Surgery, Oregon Health Sciences University, Portland, Oregon, USA. kslavin@uic.edu
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Slavin
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Baumann
authors.forename: Kim J
authors.initials: KJ
authors.lastname: Burchiel
mesh_terms: D000200:Action Potentials; D000344:Afferent Pathways / Q000503:physiopathology; D000368:Aged; D001931:Brain Mapping; D017115:Catheter Ablation; D020820:Dyskinesias / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008839:Microelectrodes; D008959:Models, Neurological; D016343:Monitoring, Intraoperative; D009474:Neurons / Q000502:physiology; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology / Q000601:surgery