Malassezia furfur meningitis associated with total parenteral nutrition subdural effusion.
We present a case of Malassezia furfur meningitis arising in a very low birth weight infant with chronic lung disease, necrotizing enterocolitis, and intraventricular hemorrhage. M. furfur meningitis was probably acquired late following successful treatment for earlier systemic central line-associated M. furfur infection. M. furfur meningitis has only once been previously reported. Unlike the previous case where meningitis was secondary to widespread blood-borne dissemination, infection was limited to the leptomeninges and arose in association with extravasation of total parenteral nutrition (TPN) and intralipid fluid into subarachnoid space via peripheral scalp catheter.
Rosales
Cecilia M
CM
Department of Pathology, Truman Medical Center, 2301 Holmes Street, Kansas City, MO 64108, USA.
Jackson
Mary Anne
MA
Zwick
David
D
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002404:Catheterization / Q000009:adverse effects; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002543:Cerebral Hemorrhage / Q000150:complications; D002908:Chronic Disease; D020345:Enterocolitis, Necrotizing / Q000150:complications; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects; D017809:Fatal Outcome; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008171:Lung Diseases / Q000150:complications; D008290:Malassezia; D008297:Male; D016921:Meningitis, Fungal / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects* / Q000295:instrumentation; D013353:Subdural Effusion / Q000209:etiology* / Q000473:pathology
D000935:Antifungal Agents; D005217:Fat Emulsions, Intravenous; D000666:Amphotericin B