title: Ivermectin resistant and susceptible third-stage larvae of Haemonchus contortus: cholinesterase and phosphatase activities.
abstract: Cholinesterase and acid phosphatase (AP), but not alkaline phosphatase activities, were detected in cytosolic and membrane-bound fractions of ivermectin resistant and susceptible Haemonchus contortus infective-stage larvae. Some differences in acetylcholinesterase activity of cytosolic fractions and in the AP activity of these fractions as well as in the response to AP inhibitors by membrane-bound fractions were detected. Data are discussed.
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá, Ctra, Madrid-Barcelona km 33, 28871 Alcalá de Henares, Madrid, España. consuelo.gimenez@uah.es
authors.forename: Consuelo
authors.initials: C
authors.lastname: Giménez-Pardo
authors.forename: Maria Mercedes
authors.initials: MM
authors.lastname: Martínez-Grueiro
authors.forename: Alicia
authors.initials: A
authors.lastname: Gómez-Barrio
authors.forename: Filomena
authors.initials: F
authors.lastname: Rodríguez-Caabeiro
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D002802:Cholinesterases / Q000378:metabolism*; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D004351:Drug Resistance; D006189:Haemonchus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D007559:Ivermectin / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000201:enzymology
chemical_list: D000871:Anthelmintics; D002800:Cholinesterase Inhibitors; D007559:Ivermectin; D002802:Cholinesterases; D000135:Acid Phosphatase