Diaminopyrimidine and diaminopyridine 5-HT7 ligands.
The present studies have identified a series of diaminopyrimidines and diaminopyridines as novel 5-HT(7) receptor ligands. Three regiosiomeric classes of pyrimidines and four regioisomeric classes of pyridines were synthesized and analyzed for binding to the 5-HT(7) receptor. The 5-HT(7) binding affinities of different regioisomers show clearly the structure-activity relationship with position of ring nitrogens.
Denhart
Derek J
DJ
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. derek.denhart@bms.com
Purandare
Ashok V
AV
Catt
John D
JD
King
H Dalton
HD
Gao
Aiming
A
Deskus
Jeffrey A
JA
Poss
Michael A
MA
Stark
Arlene D
AD
Torrente
John R
JR
Johnson
Graham
G
Mattson
Ronald J
RJ
D008024:Ligands; D011725:Pyridines / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*
D008024:Ligands; D011725:Pyridines; D011743:Pyrimidines; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor