Use of antidepressant drugs in transplant recipients.
Depression is the most prevalent psychiatric disorder in transplant recipients and may lead to noncompliance and negative outcomes without psychosocial and pharmacologic interventions. The pharmacologic treatment of depression in this patient population is complicated by complex immunosuppressant drug regimens and multiple potential drug interactions that can adversely affect the newly transplanted organs. This review provides a brief overview of the currently available antidepressant medications and highlights the clinically important features each class of agents in transplant recipients. Newer agents selective serotonin reuptake inhibitors, venlafaxine, bupropion, nefazodone, and mirtazapine are discussed as well as tricyclic antidepressants and monoamine oxidase inhibitors. A brief discussion of St. John's wort and its impact on posttransplant drug therapy is also included.
Kim
Jiwon
J
University of Southern California, School of Pharmacy, Los Angeles, California, USA.
Phongsamran
Paula
P
Park
Susie
S
D058669:Adrenergic alpha-2 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology; D016903:Drug Monitoring; D006801:Humans; D020902:Hypericum; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D014179:Neurotransmitter Uptake Inhibitors / Q000627:therapeutic use; D016377:Organ Transplantation / Q000009:adverse effects / Q000523:psychology; D018579:Patient Selection; D008517:Phytotherapy / Q000379:methods; D012449:Safety; D058830:Serotonin 5-HT2 Receptor Antagonists; D016896:Treatment Outcome; D016312:Treatment Refusal
D058669:Adrenergic alpha-2 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D008996:Monoamine Oxidase Inhibitors; D014179:Neurotransmitter Uptake Inhibitors; D058830:Serotonin 5-HT2 Receptor Antagonists