title: The relationship between aberrant methylation and survival in non-small-cell lung cancers.
abstract: The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARbeta and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.
authors.affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: S
authors.initials: S
authors.lastname: Toyooka
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: R
authors.initials: R
authors.lastname: Maruyama
authors.forename: K O
authors.initials: KO
authors.lastname: Toyooka
authors.forename: K
authors.initials: K
authors.lastname: Tsukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuyama
authors.forename: T
authors.initials: T
authors.lastname: Iizasa
authors.forename: M
authors.initials: M
authors.lastname: Aoe
authors.forename: H
authors.initials: H
authors.lastname: Date
authors.forename: T
authors.initials: T
authors.lastname: Fujisawa
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.forename: A F
authors.initials: AF
authors.lastname: Gazdar
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology*; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D019942:Genes, p16; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D004273:DNA, Neoplasm