title: The relationship between urotensin II plasma immunoreactivity and left ventricular filling pressures in coronary artery disease.
abstract: The role of urotensin II (U-II)--a vasoactive, mitogenic, and inotropic, peptide--in the pathophysiology of heart failure is controversial. The present study explores the relationship between plasma U-II immunoreactivity (U-IIIR) and hemodynamics in patients with coronary artery disease (CAD). Thirty-six patients with CAD-3 undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and 36 medical patients (MED group) with CAD-1 to CAD-3 during right heart catheterization were studied. Significant correlations were observed between pulmonary capillary wedge pressure (PCWP) and U-IIIR--determined by enzyme immunoassay (EIA)--before (rho = 0.83) and after (rho = 0.6) cardiopulmonary bypass in the CABG group. With the exception of the CPB period, CABG patients with increased PCWP before CPB had higher U-II(IR) concentrations throughout the procedure. Significant correlations were observed between U-IIIR, proANP, proBNP, and mean right ventricular pressure (RVPM) in MED patients. No correlation was detectable between U-IIIR and PCWP. However, MED patients with CAD-3 (n = 13) had higher levels of U-IIIR, NTproANPIR (RIA), NTproBNPIR (EIA) and higher cardiac filling pressures than patients with CAD-1 (n = 13). These findings support an association between plasma U-IIIR levels and diastolic myocardial dysfunction in ischemic heart failure. The discrepancies regarding left and right cardiac filling pressures and U-IIIR levels in CABG and MED patients require further evaluation.
authors.affiliation: Klinik für Anaesthesiologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. Heringlake@t-online.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Heringlake
authors.forename: Thomas
authors.initials: T
authors.lastname: Kox
authors.forename: Orhan
authors.initials: O
authors.lastname: Uzun
authors.forename: Barbara
authors.initials: B
authors.lastname: Will
authors.forename: Ludger
authors.initials: L
authors.lastname: Bahlmann
authors.forename: Stephan
authors.initials: S
authors.lastname: Klaus
authors.forename: Sawas
authors.initials: S
authors.lastname: Eleftheriadis
authors.forename: Franz Paul
authors.initials: FP
authors.lastname: Armbruster
authors.forename: Norbert
authors.initials: N
authors.lastname: Franz
authors.forename: Ernst
authors.initials: E
authors.lastname: Kraatz
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization; D016022:Case-Control Studies; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D014579:Urotensins / Q000097:blood* / Q000276:immunology*; D017725:Ventricular Pressure / Q000502:physiology*
chemical_list: D014579:Urotensins; C029677:urotensin II