C-reactive protein and atrial fibrillation. Is inflammation a consequence or a cause of atrial fibrillation?
To clarify whether inflammation is a cause or consequence of atrial fibrillation (AF), we measured high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) before and after pharmacological cardioversion in 15 patients with paroxysmal AF. Levels of hs-CRP, IL-6, and TNF-alpha after cardioversion were significantly higher than those in controls (P < 0.05). Furthermore, the levels of these indices did not differ significantly even at 24 hours and 2 weeks after cardioversion. These results suggest that inflammation is a causative agent of paroxymal AF.
Sata
Naoyuki
N
Cardiology, Shinkyo Hospital, Kagoshima, Japan.
Hamada
Naokazu
N
Horinouchi
Takashi
T
Amitani
Shigeru
S
Yamashita
Takuya
T
Moriyama
Yukinori
Y
Miyahara
Kenkichi
K
D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000209:etiology / Q000628:therapy*; D002097:C-Reactive Protein / Q000032:analysis*; D004554:Electric Countershock; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein