Phosphatidylcholine and cholesteryl esters identify the infiltrating behaviour of a clear cell renal carcinoma: 1H, 13C and 31P MRS evidence.
This study presents a multinuclear (1H, 13C and 31P) magnetic resonance spectroscopy characterization of the total lipid fraction extracted from different regions of a human kidney affected by a clear cell renal carcinoma. It was thus possible to demonstrate that cholesteryl esters and phosphatidylcholine are markers of the tumor infiltration, histologically confirmed, in the kidney medulla. The tumor tissue contains twice the amount of phosphatidylcholine compared to normal cortex. The results appear relevant in light of new clinical applications based on the biochemical composition of human tissues.
Tugnoli
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Dipartimento di Biochimica G. Moruzzi, Sez. di Chimica e Propedeutica Biochimica, 40126 Bologna, Italy. vitaliano.tugnoli@unibo.it
Poerio
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Tosi
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D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism*; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D002788:Cholesterol Esters / Q000737:chemistry*; D005260:Female; D006801:Humans; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000473:pathology; D007680:Kidney Neoplasms / Q000473:pathology* / Q000556:secondary; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009361:Neoplasm Invasiveness; D010713:Phosphatidylcholines / Q000737:chemistry*
D002788:Cholesterol Esters; D010713:Phosphatidylcholines