title: Public attitudes to human gene therapy: a pilot study in Wales.
abstract: OBJECTIVE
  This study aimed to explore some factors influencing perceptions of human gene therapy.
  
  
  METHODS
  A small qualitative study using two semi-structured interviews per participant (n = 22). The groups comprised (1) people with cystic fibrosis and members of their family (n = 9), and (2) students from a science evening class as well as lay members of the public selected from the practice list of a local general practitioner (n = 13).
  
  
  RESULTS
  This pilot study demonstrates support for somatic gene therapy and ambivalence about germline gene therapy. A clear distinction is drawn between therapy and enhancement, with the majority opposing gene enhancement.
  
  
  CONCLUSIONS
  Attitudes towards the acceptability of gene therapy are not necessarily determined by experience of, or exposure to, a genetic condition. More research is needed with the general public to determine what is perceived to be acceptable public policy in this field.
authors.affiliation: School of Care Sciences, University of Glamorgan, Pontypridd, UK. riredale@glam.ac.uk
authors.forename: Rachel
authors.initials: R
authors.lastname: Iredale
authors.forename: Gina
authors.initials: G
authors.lastname: Dolan
authors.forename: Kevin
authors.initials: K
authors.lastname: McDonald
authors.forename: Maggie
authors.initials: M
authors.lastname: Kirk
mesh_terms: D000293:Adolescent; D000328:Adult; D001294:Attitude to Health; D005260:Female; D015316:Genetic Therapy / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011639:Public Opinion; D036301:Qualitative Research; D011795:Surveys and Questionnaires; D014852:Wales