title: A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.
abstract: In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.
authors.affiliation: Dipartimento di Scienze delle Riproduzione e dello Sviluppo, University of Trieste, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Braida
authors.forename: Michele
authors.initials: M
authors.lastname: Boniotto
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pontillo
authors.forename: Pier Angelo
authors.initials: PA
authors.lastname: Tovo
authors.forename: Antonio
authors.initials: A
authors.lastname: Amoroso
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
mesh_terms: D002648:Child; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D023083:beta-Defensins / Q000235:genetics*
chemical_list: C406407:DEFB1 protein, human; D023083:beta-Defensins