title: O-Protected 3-hydroxy-oxazolidin-2,4-diones: novel precursors in the synthesis of alpha-hydroxyhydroxamic acids.
abstract: O-Protected 3-hydroxyoxazolidin-2,4-diones have been prepared in a novel one-pot reaction by subsequent treatment of cyanohydrins with 1,1'-carbonyldiimidazole and O-protected hydroxylamines followed by acidic hydrolysis of the intermediate 4-imino-oxazolidin-2-ones. Decarbonylation of O-protected 3-hydroxyoxazolidin-2,4-diones by catalytic amounts of sodium methoxide, lithium hydroxide, sodium carbonate and caesium carbonate in methanol afforded O-protected alpha-hydroxyhydroxamic acids in excellent yields. Their deprotection provided a series of novel alpha-hydroxyhydroxamic acids.
authors.affiliation: Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany. kurz@chemie.uni-hamburg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Kurz
authors.forename: Khalid
authors.initials: K
authors.lastname: Widyan