title: Prosthetic valve endocarditis due to Candida albicans treated successfully with medical treatment alone.
abstract: Prosthetic valve endocarditis (PVE) caused by Candida species is associated with high morbidity and mortality. A combination of surgical resection and antifungal drug therapy is the golden standard for treatment, yet surgical intervention is not possible in all cases of Candida PVE. We report a case of PVE due to Candida albicans cured by medical treatment alone. This case suggests that, in some instances, Candida PVE can be managed medically with antifungal therapy. Such a conservative approach should be applied with caution and necessitates very close follow-up on a long-term basis.
authors.affiliation: Department of Cardiovascular Surgery, Nagasaki Municipal Medical Center, Nagasaki, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Noguchi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takai
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Eishi
authors.forename: Sunao
authors.initials: S
authors.lastname: Atogami
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000382:microbiology*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D004697:Endocarditis, Bacterial / Q000150:complications / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole