title: Presumed central anticholinergic syndrome from inadvertent intravenous hyoscine hydrobromide (scopolamine) injection.
abstract: We present a case of presumed central anticholinergic syndrome due to a drug administration error. A 35-year-old woman was slow to emerge from anaesthesia for laparoscopic biliary surgery. Postoperative neurological and metabolic abnormalities were later diagnosed as central anticholinergic syndrome. Only after resolution of the clinical problems did the drug error origin of the syndrome become apparent. It was realized that hyoscine hydrobromide (scopolamine) had been inadvertently administered intraoperatively for biliary relaxation, instead of hyoscine butylbromide. This case report describes central anticholinergic syndrome and highlights potential problems involved for anaesthetists administering drugs they do not commonly use.
authors.affiliation: Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth, Western Australia.
authors.forename: J
authors.initials: J
authors.lastname: Wilden
authors.forename: D
authors.initials: D
authors.lastname: Rapeport
mesh_terms: D000328:Adult; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage; D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008508:Medication Errors; D018727:Muscarinic Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D012601:Scopolamine / Q000008:administration & dosage* / Q000009:adverse effects; D013577:Syndrome
chemical_list: D018727:Muscarinic Antagonists; D002086:Butylscopolammonium Bromide; D012601:Scopolamine