Safety of mefloquine in infants with acute falciparum malaria.
We evaluated retrospectively the safety of mefloquine (25 mg/kg) for the curative treatment of uncomplicated Plasmodium falciparum malaria in 26 infants weighing <15 kg and managed during a 5-year period. Side effects were recorded in 30.8% of patients and consisted chiefly of mild and transient gastrointestinal symptoms. Mefloquine was safe in infants weighing <15 kg in our experience.
Dubos
François
F
Pediatric Intensive Care Unit, Jeanne de Flandre Hospital, Lille, France. frandubos@wanadoo.fr
Delattre
Pierre
P
Demar
Magali
M
Carme
Bernard
B
Gendrel
Dominique
D
D000208:Acute Disease; D000962:Antimalarials / Q000009:adverse effects / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002675:Child, Preschool; D005260:Female; D006172:Guyana; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D015767:Mefloquine / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
D000962:Antimalarials; D015767:Mefloquine