Induction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitization.
Age is an important factor in determining the quantity and quality of immune responses when challenged with allergen. In a model of allergen-induced airway hyperresponsiveness and inflammation, where the sensitization phase and challenge phases can be dissociated in time, we examined the impact of age on these two phases. Sensitization of young mice (1-20 wk), but not older animals (30-40 wk), led to the development of airway hyperresponsiveness, airway eosinophilia, Th2 cytokine responses, and allergen-specific IgE, regardless of the age when the challenge phase was conducted. Thus, age at the time of initial sensitization was shown to be the critical factor dictating the nature of the response to later allergen challenge, as older mice remained responsive to allergen challenge if sensitized at a young age. These effects were shown to be mediated by lung T cells from sensitized young mice. Moreover, the failure of old sensitized mice to mediate these effects was shown not to be the result of active suppression of the responses. These data define the importance of age at initial allergen exposure in dictating subsequent responses in the lung when exposed to allergen and may help to define why asthma, even in adults, is most often initiated in early childhood.
Gelfand
Erwin W
EW
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA. gelfande@njc.org
Joetham
Anthony
A
Cui
Zhi-Hua
ZH
Balhorn
Annette
A
Takeda
Katsuyuki
K
Taube
Christian
C
Dakhama
Azzeddine
A
D000367:Age Factors; D000485:Allergens / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006967:Hypersensitivity / Q000276:immunology*; D051379:Mice; D012137:Respiratory System / Q000276:immunology* / Q000378:metabolism
D000485:Allergens; D016207:Cytokines