More than cell death: caspases and caspase inhibitors on the move.
It is becoming clear that "apoptotic" caspases can effect cellular processes other than cell death. A recent paper in Cell points to a novel role of the Drosophila caspase inhibitor DIAP1 as a determinant of cell migration.
Dotto
G Paolo
GP
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Silke
John
J
D000818:Animals; D020169:Caspases / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D051034:Inhibitor of Apoptosis Proteins; D015398:Signal Transduction / Q000235:genetics; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism
D015853:Cysteine Proteinase Inhibitors; C111891:DIAP1 protein, Drosophila; D029721:Drosophila Proteins; D051034:Inhibitor of Apoptosis Proteins; D020169:Caspases; D020830:rac1 GTP-Binding Protein