title: Effects of garlic (Allium sativum) extract on the heart rate, rhythm and force of contraction in frog: a dose-dependent study.
abstract: Garlic juice (dose equivalent to 3.3 g to 33 g garlic) mainly caused bradycardia in frog Rana tigerina. The disturbance in ventricular rhythm was observed prior to than that of atria. Rhythm was specially disturbed at higher doses causing bizarre pattern. Force of contraction of the heart also decreased with higher dose of the garlic extract. The results suggest that garlic extract has some beneficial effect on heart rate modulating the rate, rhythm and force of contraction positively but very high doses may exert non-desirable effects as well.
authors.affiliation: Department of Physiology, King George's Medical College, Lucknow 226 003, India. rajkumaryad@hotmail.com
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Yadav
authors.forename: Nar Singh
authors.initials: NS
authors.lastname: Verma
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005609:Free Radicals; D005737:Garlic / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D008956:Models, Chemical; D009119:Muscle Contraction; D009200:Myocardial Contraction / Q000187:drug effects*; D010936:Plant Extracts; D011898:Ranidae
chemical_list: D005609:Free Radicals; D010936:Plant Extracts