Biocompatibility and biostability of a series of poly(carbonate)urethanes.
In this work, we synthesized several MDI-based poly(carbonate)urethanes (PCU) by using four different soft segments, including two aliphatic macrodiols (poly(hexyl, ethyl)carbonate diols, MW 2017 and 865, respectively) and two aromatic macrodiols (MW approximately 2000 and 1000, respectively), in different molar ratios to MDI. We demonstrate that these polymers exhibited various degree of micro-phase separation that further influenced their surface protein adsorption, platelet activation as well as cellular attachment and growth. Polyurethanes based on poly(hexyl, ethyl)carbonate diol with MW 2017 in a molar ratio MDI/macrodiol/chain extender of either 3/2/1 or 4/3/1 resulted in greater micro-phase separation as well as superior biocompatibility and biostability.
Hsu
Shan-Hui
SH
Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan, ROC. shhsu@nchu.edu.tw
Lin
Zu-Chang
ZC
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D002254:Carbonates / Q000737:chemistry*; D002417:Cattle; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004355:Drug Stability; D004730:Endothelium, Vascular / Q000187:drug effects; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D008970:Molecular Weight; D015539:Platelet Activation; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012822:Silicon Dioxide / Q000494:pharmacology; D013696:Temperature; D013718:Tensile Strength; D014471:Umbilical Veins / Q000166:cytology; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D002254:Carbonates; D011140:Polyurethanes; D014867:Water; D012710:Serum Albumin, Bovine; D012822:Silicon Dioxide; D005340:Fibrinogen