title: The Tei index permits evaluation of cardiopulmonary function during inhaled nitric oxide therapy in the hypoxic newborn piglet.
abstract: The purpose of this study was to test the effectiveness of a new Doppler index combining systolic and diastolic time intervals (the Tei index) in the prospective assessment of ventricular function and pulmonary circulation in a newborn piglet model with hypoxic pulmonary hypertension during inhaled nitric oxide (NO). Piglets were prepared for the experiments under normal air, hypoxia, and hypoxia-with-inhaled-NO conditions. Complete two-dimensional Doppler echocardiographic examinations were performed in each condition. The right-ventricle (RV) Tei index increased with hypoxia and decreased following the inhalation of NO. Furthermore, there was a direct correlation between the individual changes in the RV Tei index and individual changes in mean pulmonary arterial pressure in each condition. We conclude that the Tei index is useful for assessing cardiac function and pulmonary circulation in hypoxic pulmonary hypertension during inhaled NO. These results suggest that the Tei index provides an objective assessment of persistent pulmonary hypertension of the newborn.
authors.affiliation: Department of Pediatrics, Neonatology, and Congenital Disorders, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan. osugi@med.nagoya-cu.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sugiura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Mohamed Hamed
authors.initials: MH
authors.lastname: Hussein
authors.forename: Takenori
authors.initials: T
authors.lastname: Kato
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Okubo
authors.forename: Hiroki
authors.initials: H
authors.lastname: Imamine
authors.forename: Tokio
authors.initials: T
authors.lastname: Sugiura
authors.forename: Hajime
authors.initials: H
authors.lastname: Togari
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002245:Carbon Dioxide / Q000097:blood; D003971:Diastole; D006321:Heart / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000503:physiopathology; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D008168:Lung / Q000098:blood supply / Q000502:physiology*; D009569:Nitric Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood; D015203:Reproducibility of Results; D013552:Swine; D013599:Systole; D013997:Time Factors; D018615:Ultrasonography, Doppler, Color; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right
chemical_list: D002245:Carbon Dioxide; D009569:Nitric Oxide; D010100:Oxygen