title: Preliminary report of endolaryngeal and endotracheal laser surgery of juvenile-onset recurrent respiratory papillomatosis by Nd:YAG laser and a new fiber guidance instrument.
abstract: OBJECTIVE
  Recurrent respiratory papillomatosis (RRP) caused by human papilloma virus (type 6 and 11) is the most common benign neoplasm of the larynx in children. Despite being a benign disease, treatment is very difficult and is characterized by frequent recurrence, spread throughout the respiratory tract, and malignant degeneration. Besides surgical resection and the established CO(2) laser treatment, laser surgery by fiber-guided Nd:YAG laser light promises to be a bloodless and effective treatment procedure. To improve this new method, a novel fiber guidance instrument has been developed to aid in endolaryngal laser surgery of RRP. Study design and setting The method described uses a specially designed instrument for fiber guidance that is equipped with a bendable distal tip to move the fiber end precisely. Moreover, the instrument includes an additional channel for the suction of smoke and pyrolysis products. Up to now, 5 patients (aged 4 to 8 years) with RRP were treated by Nd:YAG laser light (lambda = 1064 nm; power, 10 W; irradiance, 3.5 kW/cm(2), continuous wave) with a prototype version of the new instrument and were followed up for 12 months each.
  
  
  RESULTS
  Because of the adequate length and the bendable distal tip with a range of -5 degrees up to 45 degrees to the optical axis of the fiber and less than 10% light loss at maximal deflection, RRP can be treated by Nd:YAG laser light easily and precisely. The continuous suctioning ensured an optimum view of the operating field and a minimal load of potential infectious laser plume and toxic pyrolysis products for the patient as well as for the physician. The laser treatment of RRP with the new fiber guidance instrument was only minimally traumatic. During 1-year follow-up visits, all Nd:YAG laser light-treated patients, showed a regression of the disease.
  
  
  CONCLUSIONS
  The new fiber guidance instrument enables a precise and easy treatment of the RRP with fiber-guided laser systems (eg, Nd:YAG-, diode-, and KTP-lasers) and an effective removal of infectious laser plume as well as toxic pyrolysis products. A follow-up period of 1 year revealed that Nd:YAG laser surgery seems to prevent a rapid recurrence of juvenile respiratory papillomatosis in the treated patients.
authors.affiliation: Department of Otorhinolaryngology, Ludwig-Maximilians University, Munich, Germany. philip.janda@gmx.de
authors.forename: Philip
authors.initials: P
authors.lastname: Janda
authors.forename: Andreas
authors.initials: A
authors.lastname: Leunig
authors.forename: Ronald
authors.initials: R
authors.lastname: Sroka
authors.forename: Christian S
authors.initials: CS
authors.lastname: Betz
authors.forename: Gerd
authors.initials: G
authors.lastname: Rasp
mesh_terms: D002648:Child; D002675:Child, Preschool; D005336:Fiber Optic Technology / Q000295:instrumentation*; D005500:Follow-Up Studies; D006801:Humans; D007828:Laryngoscopy / Q000379:methods; D053685:Laser Therapy / Q000295:instrumentation*; D010212:Papilloma / Q000209:etiology / Q000601:surgery*; D030361:Papillomavirus Infections / Q000150:complications / Q000601:surgery*; D012008:Recurrence; D012140:Respiratory Tract Diseases / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome