title: Does early decompression improve neurological outcome of spinal cord injured patients? Appraisal of the literature using a meta-analytical approach.
abstract: METHODS
  Definitive and unequivocal evidence to support the practice of early or late surgery is still lacking in clinical studies. Accordingly, meta-analysis is one of the few methods that offer a rational, statistical approach to management decision. A review of the clinical literature on spinal cord injury with emphasis on the role of early surgical decompression and a meta-analysis of results was performed.
  
  
  OBJECTIVE
  To determine whether neurological outcome is improved in traumatic spinal cord-injured patients who had surgery within 24 h as compared with those who had late surgery or conservative treatment.
  
  
  METHODS
  A Medline search covering the period 1966-2000, supplemented with manual search, was used to locate studies containing information on indication, rationale and timing of surgical decompression after spinal cord injuries. The analysis included a total of 1687 eligible patients.
  
  
  RESULTS
  Statistically, early decompression resulted in better outcome compared with both conservative (P<0.001) and late management (P<0.001). Nevertheless, analysis of homogeneity showed that only data regarding patients with incomplete neurological deficits who had early surgery were reliable.
  
  
  CONCLUSIONS
  Although statistically the percentage of patients with incomplete neurological deficits improving after early decompression appear 89.7% (95% confidence interval: 83.9, 95.5%), to be better than with the other modes of treatment when taking into consideration the material available for analysis and the various other factors including clinical limitations; early surgical decompression can only be considered as practice option for all groups of patients.
authors.affiliation: Neurosurgical Clinic, University of Messina School of Medicine, Messina, Italy.
authors.forename: G
authors.initials: G
authors.lastname: La Rosa
authors.forename: A
authors.initials: A
authors.lastname: Conti
authors.forename: S
authors.initials: S
authors.lastname: Cardali
authors.forename: F
authors.initials: F
authors.lastname: Cacciola
authors.forename: F
authors.initials: F
authors.lastname: Tomasello
mesh_terms: D002986:Clinical Trials as Topic; D015897:Comorbidity; D019299:Decompression, Surgical / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D007796:Laminectomy / Q000379:methods / Q000706:statistics & numerical data; D009422:Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D009460:Neurologic Examination; D017063:Outcome Assessment, Health Care / Q000379:methods*; D013119:Spinal Cord Injuries / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D016896:Treatment Outcome