title: Creating a stem cell donor: a case study in reproductive genetics.
abstract: During the nearly 10 years since its introduction, preimplantation genetic diagnosis (PGD) has been used predominantly to avoid giving birth to a child with identified genetic disease. Recently, PGD was used by a couple not only to test IVF-created embryos for genetic disease, but also to test for a nondisease trait related to immune compatibility with a child in the family in need of an hematropoetic stem cell transplant. This article describes the case, raises some ethical and policy issues, highlights gaps in U.S. policy, and finally makes some recommendations for addressing advancing genetic and reproductive technologies.
authors.affiliation: Center for Bioethics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Kahn
authors.forename: Anna C
authors.initials: AC
authors.lastname: Mastroianni
mesh_terms: D026683:Advisory Committees; D033001:Directed Tissue Donation / Q000941:ethics; D019924:Embryo Disposition; D004624:Embryo Transfer; D026689:Ethical Analysis; D026724:Ethical Review; D005199:Fanconi Anemia; D005307:Fertilization in Vitro; D005312:Fetal Blood / Q000637:transplantation; D005820:Genetic Testing / Q000941:ethics; D006648:Histocompatibility; D006801:Humans; D007231:Infant, Newborn; D009042:Motivation; D010290:Parents; D019836:Preimplantation Diagnosis / Q000941:ethics; D011640:Public Policy; D012098:Reproduction / Q000941:ethics*; D035781:Siblings; D012926:Social Control, Formal; D033581:Stem Cell Transplantation / Q000941:ethics; D014481:United States