Drug toxicity in the neonate.
The incidence of adverse drug reactions in neonates is thought to be at least 10%. The physiology of the newborn infant is different to that of both paediatric patients and adults. This therefore predisposes to certain types of drug toxicity, which are described below. Medication errors are also a significant problem in the neonatal period due to the lack of appropriate formulations designed for neonates.
McIntyre
John
J
Academic Division of Child Health, University of Nottingham, Derbyshire Children's Hospital, Derby, UK.
Choonara
Imti
I
D000814:Aniline Compounds / Q000009:adverse effects; D002626:Chemistry, Pharmaceutical; D002701:Chloramphenicol / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D008508:Medication Errors / Q000009:adverse effects; D009294:Narcotics / Q000633:toxicity; D013449:Sulfonamides / Q000009:adverse effects
D000814:Aniline Compounds; D009294:Narcotics; D013449:Sulfonamides; D002701:Chloramphenicol