Exclusion of galectin 9 as a candidate gene for hyperuricosuria in the Dalmatian dog.
All Dalmatian dogs have an inherited defect in purine metabolism leading to high levels of uric acid excretion in their urine (hyperuricosuria) rather than allantoin, the normal end product of purine metabolism in all other breeds of dog. Transplantation experiments have demonstrated that the defect is intrinsic to the liver and not the kidney. Uricase, the enzyme involved in the breakdown of urate into allantoin, has been shown to function in Dalmatian liver cells. Therefore, candidate genes for this defect include transporters of urate, a salt of uric acid, across cell membranes. We excluded one such urate transporter candidate, galectin 9, using a Dalmatian x Pointer backcross in which hyperuricosuria was segregating.
Bannasch
D L
DL
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. dlbannasch@ucdavis.edu
Ryun
J R
JR
Bannasch
M J
MJ
Schaible
R H
RH
Breen
M
M
Ling
G
G
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics; D003433:Crosses, Genetic; D017931:DNA Primers; D004283:Dog Diseases / Q000235:genetics* / Q000652:urine; D004285:Dogs; D037161:Galectins / Q000235:genetics*; D033461:Hyperuricemia / Q000235:genetics / Q000652:urine / Q000662:veterinary*; D008126:Lod Score; D018895:Microsatellite Repeats / Q000235:genetics; D008969:Molecular Sequence Data; D027361:Organic Anion Transporters / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D021101:Radiation Hybrid Mapping; D017422:Sequence Analysis, DNA; D013045:Species Specificity
D002352:Carrier Proteins; D017931:DNA Primers; D037161:Galectins; D027361:Organic Anion Transporters; C103862:urate transporter