Xanthone isolated from Securidaca longependunculata with activity against erectile dysfunction.
1,7-Dimethoxy-2-hydroxy-xanthone and 1,4-dihydroxy-7-methoxy-xanthone isolated from Securidaca longependunculata were tested for their activity on rabbit corpus cavernosum in vitro. Only the former relaxed the corpus cavernosum by 63% at 1.8 x 10(-5) mg/ml.
Rakuambo
N C
NC
Department of Botany, University of Pretoria, Pretoria, South Africa.
Meyer
J J M
JJ
Hussein
A
A
D000818:Animals; D007172:Erectile Dysfunction / Q000188:drug therapy*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D011817:Rabbits; D031802:Securidaca; D044004:Xanthones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D010936:Plant Extracts; D044004:Xanthones