title: 5-HT1A receptor activation before acute stress counteracted the induced long-term behavioral effects.
abstract: The long-term behavioral consequences of acute immobilization (IMMO) in rats and the effects of 5-HT(1A) receptor activation (8-OH-DPAT: 0.3 mg/kg, sc) were studied. Corticosterone levels after IMMO with previous 8-OH-DPAT treatment were also studied. Twenty-four hours after IMMO (3 h), rats performed conditioned (passive avoidance) and unconditioned (escape behavior) anxiety tests in the elevated T maze. Pre-exposure to IMMO induces long-term behavioral changes in contrast with control rats. These behavioral alterations include an increase of anxiogenic responses, such as exploratory behavior and passive avoidance response. This effect was counteracted by 8-OH-DPAT pretreatment and reversed by WAY-100635 when administered before 8-OH-DPAT. Serum corticosterone levels increased during the first hour of stress and after 8-OH-DPAT administration. Our results support the hypothesis that involvement of acute stress is crucial in the anxiety-like behaviors and in the potentiation of fear. The activation of 5-HT(1A) receptors counteracted the long-term effects induced by IMMO.
authors.affiliation: Department of Psychobiology, School of Psychology, University of Malaga, Campus de Teatinos s/n, 29071, Málaga, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Rioja
authors.forename: L J
authors.initials: LJ
authors.lastname: Santín
authors.forename: M
authors.initials: M
authors.lastname: García
authors.forename: A
authors.initials: A
authors.lastname: Doña
authors.forename: L
authors.initials: L
authors.lastname: De Pablos
authors.forename: M I
authors.initials: MI
authors.lastname: Cuadrado
authors.forename: F J
authors.initials: FJ
authors.lastname: Alcalde
authors.forename: S
authors.initials: S
authors.lastname: González-Barón
authors.forename: J A
authors.initials: JA
authors.lastname: Aguirre
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D007103:Immobilization; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D058825:Serotonin 5-HT1 Receptor Agonists; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D010879:Piperazines; D011725:Pyridines; D058825:Serotonin 5-HT1 Receptor Agonists; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin