JNK regulates expression and autocrine signaling of TGF-beta1.
TGF-beta1 can induce its own expression by an autoregulatory mechanism. In this issue of Molecular Cell, Ventura et al. (2004) show, using JNK-deficient fibroblasts, that JNK negatively regulates TGF-beta1 gene expression and, consequently, autocrine TGF-beta signaling. The results highlight the contributions of JNK signaling in the control of TGF-beta expression and signaling, and of autocrine TGF-beta signaling in the JNK-regulated changes in cell behavior.
Pardoux
Cécile
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Department of Growth and Development, University of California at San Francisco, 513 Parnassus Avenue, Room HSW-613, 94143, USA.
Derynck
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D000818:Animals; D019898:Autocrine Communication; D005347:Fibroblasts / Q000378:metabolism; D048031:JNK Mitogen-Activated Protein Kinases; D051379:Mice; D018345:Mice, Knockout; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1
C508961:Tgfb1 protein, mouse; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases