title: TP53 codon 72 polymorphism in patients with chronic myeloid leukemia.
abstract: A single nucleotide polymorphism at TP53 codon 72 means that two alleles exist: A1 (proline residue, Pro72) and A2 (arginine residue, Arg72). The Pro72 variant of p53 has a lower apoptotic potential. We found that allele A1 was more frequent in patients with chronic myeloid leukemia (CML) than in controls, and among CML patients who had no cytogenetic response than among responders.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Bergamaschi
authors.forename: Serena
authors.initials: S
authors.lastname: Merante
authors.forename: Ester
authors.initials: E
authors.lastname: Orlandi
authors.forename: Anna
authors.initials: A
authors.lastname: Galli
authors.forename: Paolo
authors.initials: P
authors.lastname: Bernasconi
authors.forename: Mario
authors.initials: M
authors.lastname: Cazzola
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D003062:Codon; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic
chemical_list: D003062:Codon