[Study on the effect of weitongning on epidermal growth factor and nitric oxide contents in tissue of stomach of rats with gastric ulcer].
OBJECTIVE
To study the therapeutic mechanism of weitongning (WTN) in treating peptic ulcer.


METHODS
Rat model of chronic gastric ulcer induced by glacial acetic acid was used to observe the effect of WTN on the curative quality, thickness of regenerated mucous membrane, epidermal growth factor (EGF) and nitric oxide (NO) contents in scar tissue around the gastric ulcer.


RESULTS
The thickness of regenerated mucous membrane, EGF and NO contents in peri-ulcer scar tissue were higher in the model rats after WTN treatment than that in the untreated model rats (P<0.01 or P<0.05).


CONCLUSIONS
WTN could elevate the quality of ulcer curing, to raise the EGF and NO contents in peri-ulcer scar tissue might be one of its mechanisms for preventing relapse of peptic ulcer.
Zheng
Xue-gang
XG
Affiliated Hospital of Medical School, Hubei College of Nationalities, Wuhan (445000). zbwgmy@sina.com
Zhang
Jian-jun
JJ
Huang
Yun-chun
YC
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000378:metabolism*
D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D004815:Epidermal Growth Factor