Regio- and stereospecific syntheses of syn- and anti-1,2-imidazolylpropylamines from the reaction of 1,1'-carbonyldiimidazole with syn- and anti-1,2-amino alcohols.
The regio- and stereospecific conversion of syn- and anti-1,2-amino alcohols to their respective syn- and anti-1,2-imidazolylpropylamines via treatment with 1,1'-carbonyldiimidazole is described. The rationale behind the regio- and stereospecific nature as well as the generality of the reaction is discussed.
Mulvihill
Mark J
MJ
OSI Pharmaceuticals, Inc., Broadhollow Bioscience Park, 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. mark.mulvihill@osip.com
Cesario
Cara
C
Smith
Vanessa
V
Beck
Patricia
P
Nigro
Anthony
A
D000605:Amino Alcohols / Q000737:chemistry*; D006632:Histamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000605:Amino Alcohols; D007093:Imidazoles; C047962:imidazolyl-4-propylamine; C006900:N,N-carbonyldiimidazole; D006632:Histamine