The mouse "tool box" for meiotic studies.
Besides availability, there are numerous advantages to using mice for meiotic studies: (1) techniques exist for enriching the population of spermatocytes at particular meiotic stages; (2) spermatogenesis in mice is highly synchronized and testis sections afford a highly accurate method of staging meiotic events; (3) knock-out mice provide a rich source of meiotic mutants. Coupled with antibody localization techniques these tools, singularly and in combination, provide multiple means of temporally and physically dissecting meiosis.
Ashley
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Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA. Terry.Ashley@yale.edu
D000818:Animals; D007158:Immunologic Techniques; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008540:Meiosis / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D053473:Nod2 Signaling Adaptor Protein; D013090:Spermatocytes / Q000166:cytology; D013573:Synaptonemal Complex / Q000276:immunology / Q000502:physiology; D013737:Testis / Q000166:cytology; D014802:Vitamin A Deficiency
D047908:Intracellular Signaling Peptides and Proteins; D053473:Nod2 Signaling Adaptor Protein; C495945:Nod2 protein, mouse