title: The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons.
abstract: The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: Stephanie S
authors.initials: SS
authors.lastname: Strand
authors.forename: Tambryn K
authors.initials: TK
authors.lastname: Vanheyningen
authors.forename: David A
authors.initials: DA
authors.lastname: Leib
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics; D018259:Herpesvirus 1, Human / Q000502:physiology*; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D012260:Ribonucleases; D014709:Vero Cells; D014764:Viral Proteins / Q000502:physiology*
chemical_list: D014764:Viral Proteins; C070722:virion host shutoff protein, Simplexvirus; D012313:RNA; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D012260:Ribonucleases