title: Cannabinoids in pain and inflammation.
abstract: Cannabinoids exhibit medicinal properties including analgesic, anti-inflammatory and immunosuppressive properties. This paper reviews some of the recent findings in the study of cannabinoids in pain and inflammation. Some of the effects of cannabinoids are receptor mediated and others are receptor independent. Endocannabinoids naturally reduce pain and are cerebroprotective. Natural and synthetic cannabinoids have the potential to reduce nociception, reverse the development of allodynia and hyperalgesia, reduce inflammation and inflammatory pain and protect from secondary tissue damage in traumatic head injury.
authors.affiliation: Biomedical Research Centre, Sheffield Hallam University, School of Science and Mathematics, Howard Street, Sheffield, S1 1WB, UK. Mbvundula@student.shu.ac.uk
authors.forename: Estery C
authors.initials: EC
authors.lastname: Mbvundula
authors.forename: K D
authors.initials: KD
authors.lastname: Rainsford
authors.forename: Rowena A D
authors.initials: RA
authors.lastname: Bunning
mesh_terms: D000818:Animals; D063386:Cannabinoid Receptor Agonists; D002186:Cannabinoids / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D043882:Receptors, Cannabinoid / Q000378:metabolism
chemical_list: D063386:Cannabinoid Receptor Agonists; D002186:Cannabinoids; D043882:Receptors, Cannabinoid