Two complementary approaches toward 2-alkoxy carboxylic acid synthesis from 1,3-dioxolan-4-ones.
Two complementary approaches to prepare 2-alkoxy carboxylic acids have been developed. Reductive ring opening of various 1,3-dioxolan-4-ones using TiCl(4)/Et(3)SiH or (t)BuMgCl affords the desired 2-alkoxy carboxylic acid in moderate to excellent chemical yield without loss of optical purity.
Winneroski
Leonard L
LL
Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
Xu
Yanping
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