title: Secondary Philadelphia chromosome in a patient with acute lymphoblastic leukemia.
abstract: We report the case of a patient with acute lymphoblastic leukemia who developed a secondary Philadelphia chromosome-positive clone (Ph(+)). Although the Ph was not detected at diagnosis with conventional cytogenetic analysis and with molecular methods (reverse transcriptase polymerase chain reaction), the Ph was detected with the same techniques at relapse. This anomaly is usually related to the initiation of the disease, but can be a late event related to progression. We discuss these hypotheses and review the literature.
authors.affiliation: Department of Hematology, Cytogenetic Department, Centre Henri Becquerel, 1 Rue D'amiens, Rouen, France.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Aspasia
authors.initials: A
authors.lastname: Stamatoullas
authors.forename: Christian
authors.initials: C
authors.lastname: Bastard
authors.forename: Hervé
authors.initials: H
authors.lastname: Tilly
mesh_terms: D000328:Adult; D016044:Fusion Proteins, bcr-abl / Q000032:analysis; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology
chemical_list: D016044:Fusion Proteins, bcr-abl