Diminished retention of food in the proximal stomach correlates with increased acidic reflux in patients with gastroesophageal reflux disease and dyspeptic symptoms.
This work aimed at evaluating the intragastric distribution of food in patients with GERD and dyspepsia and its relationship to acidic reflux episodes. Gastric emptying and food retention in the proximal stomach were evaluated by scintigraphy in 12 healthy subjects and 19 patients with GERD and dyspepsia after a liquid test meal. Patients also underwent 24-hr esophageal pH monitoring, which included a 2-hr postprandial period following a similar test meal. Total gastric emptying was similar in patients and controls, whereas proximal gastric retention (AUCprox/AUCtot) was significantly decreased in patients (mean +/- SD: 0.48 +/- 0.07 vs. 0.56 +/- 0.06; P = 0.02). Within the GERD-dyspepsia group, a significant negative correlation was found between proximal gastric retention and the number of acidic reflux episodes. We concluded that abnormally decreased retention of gastric contents in the proximal stomach after a liquid meal may contribute to the pathogenesis of acidic reflux episodes in patients with GERD and dyspepsia.
Herculano
José Ruver L
JR
Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Campus of Ribeirão Preto, CEP 14048-900, Ribeirão Preto, São Paulo, Brazil.
Troncon
Luiz E A
LE
Aprile
Lilian R O
LR
Moraes
Eder R
ER
Secaf
Marie
M
Onofre
Pedro H C
PH
Dantas
Roberto O
RO
Oliveira
Ricardo B
RB
D000328:Adult; D004415:Dyspepsia / Q000503:physiopathology*; D005260:Female; D005502:Food; D005744:Gastric Acid / Q000502:physiology*; D005746:Gastric Emptying / Q000502:physiology*; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000503:physiopathology*