In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis.
The antimicrobial peptide protegrin-1 (PG-1) inhibited the growth in vitro of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis; a lower activity was shown by human beta-defensin-1 (HBD-1) against both strains. The combination of PG-1 or HBD-1 with isoniazid significantly reduced M. tuberculosis growth in comparison with the peptides or isoniazid alone.
Fattorini
Lanfranco
L
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
Gennaro
Renato
R
Zanetti
Margherita
M
Tan
Dejiang
D
Brunori
Lara
L
Giannoni
Federico
F
Pardini
Manuela
M
Orefici
Graziella
G
D000890:Anti-Infective Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D004357:Drug Synergism; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D023083:beta-Defensins / Q000494:pharmacology*
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; C406407:DEFB1 protein, human; D011506:Proteins; D023083:beta-Defensins; C094880:protegrin-1; D007538:Isoniazid