Do human RNA helicases have a role in cancer?
Human RNA helicases (HRH) represent a large family of enzymes that play important roles in RNA processing. The biochemical characteristics and biological functions of the majority of HRH are still to be determined. However, there are examples of dysregulation of HRH expression in various types of cancer. In addition, some HRH have been shown to be involved in the regulation of, or the molecular interaction with, molecules implicated in cancer. Other helicases take part in fusion transcripts resulting from cancer-associated chromosomal translocation. These findings raise the question of whether HRH can contribute to cancer development/progression. In this review, I summarize the cancer-related features of HRH.
Abdelhaleem
Mohamed
M
Division of Haematopathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, University of Toronto, Room 3691 Atrium, 555 University Avenue, Toronto, ON M5G 1X8, Canada. mohamed.abdelhaleem@sickkids.ca
D053487:DEAD-box RNA Helicases; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000201:enzymology*; D011518:Proto-Oncogene Proteins; D020365:RNA Helicases / Q000502:physiology*; D012316:RNA Nucleotidyltransferases
D008565:Membrane Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D012316:RNA Nucleotidyltransferases; C086252:DDX1 protein, human; C094683:DDX6 protein, human; C098487:DHX9 protein, human; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases