title: Cirrhosis progression as a model of accelerated senescence: affecting the biological aging clock by a breakthrough biophysical methodology.
abstract: To test new treatment modalities, a pilot study with a novel noninvasive biophysical methodology (Delta-S DVD) that can artificially exert a "decrease of entropy" through the patented electromagnetic-driven delivery of "energy clusters" was designed. This process has been modulated and integrated by the body as a "self" source to support the energy-dependent functional stores, thus modifying reparative into regenerative mechanisms of liver parenchyma. Seven long-standing hepatitis C virus-positive (Child A-B) cirrhosis patients with overt symptoms and portal hypertension and failure or side effects of antiviral drug treatment underwent 40-min sessions of Delta-S DVD daily for six months and were followed up monthly. At the end of the first month, rapid improvement of symptoms and a decrease of portal hypertension were noted. At the end of treatment, all patients showed either a complete (80%) or a partial (20%) regression of fatigue (FISK score), peripheral edema, pruritus, and palmar erythema. As observed, despite having stopped beta-blockers, F1 esophageal varices disappeared (60%), whereas F2 decreased to F1. The Doppler ultrasound aspect of partial (40%) or total (20%) atrophy was either reduced (60%) or reverted to normal (20%), and the respiratory dynamics of the portal vein improved (80%) or normalized (20%), whereas gross scarring nodules disappeared in 40% of cases. These promising data pave the way for an innovative physiopathological approach with extensive clinical applications.
authors.affiliation: Delta Research and Development, Research Center for Medical Bioengineering, Tor vergata University, Rome, Italy. g.marineo@mclink.it
authors.forename: G
authors.initials: G
authors.lastname: Marineo
authors.forename: F
authors.initials: F
authors.lastname: Marotta
authors.forename: G
authors.initials: G
authors.lastname: Sisti
mesh_terms: D000375:Aging; D001683:Biological Clocks; D003863:Depression; D018450:Disease Progression; D004574:Electromagnetic Fields; D019277:Entropy; D004932:Esophageal and Gastric Varices / Q000628:therapy; D005221:Fatigue; D005355:Fibrosis / Q000473:pathology* / Q000628:therapy*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D006975:Hypertension, Portal / Q000628:therapy; D013816:Thermodynamics; D013997:Time Factors