Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment.
IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail. We studied the biological activities of TSLP in B cell development at distinct ages in the mouse. On the one hand, TSLP is able to give rise to a measurable B1 cell compartment derived from fetal liver pro-B cells, although, as is the case for B2 cells, it does not play a prevalent role in the development of this subset. On the other hand, TSLP drives the proliferation of pro-B cells from the fetal and neonatal liver, but in the bone marrow environment, B cell precursors require pre-B cell receptor expression for TSLP responsiveness.
Vosshenrich
Christian A J
CA
Unité des Cytokines et Développement Lymphoïde, Institut National de la Santé et de la Recherche Médicale, Institut Pasteur, 75724 Paris, France.
Cumano
Ana
A
Müller
Werner
W
Di Santo
James P
JP
Vieira
Paulo
P
D019264:Adoptive Transfer; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology*; D005434:Flow Cytometry; D015851:Interleukin-7 / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D009928:Organ Specificity; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*; D017154:Stromal Cells / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*
D015851:Interleukin-7; D011947:Receptors, Antigen, B-Cell