title: Evaluation of a high-dose dexamethasone-eluting stent.
abstract: This study evaluated the safety and efficacy of a dexamethasone-eluting stent with a special high dexamethasone-loading dose for treatment of de novo coronary lesions in 30 patients. Eight patients had in-stent restenosis (restenosis rate 31%) at 6-month follow-up, and the in-stent late lumen loss was 0.96 +/- 0.63 mm due to an average intimal hyperplasia area obstruction of 32 +/- 21%, indicating that high-dose dexamethasone-loaded stents do not significantly reduce neointimal proliferation.
authors.affiliation: Medical Clinic I, University Hospital Aachen, Germany. RHoffman@UKAACHEN.de
authors.forename: Rainer
authors.initials: R
authors.lastname: Hoffmann
authors.forename: Roswitha
authors.initials: R
authors.lastname: Langenberg
authors.forename: Peter
authors.initials: P
authors.lastname: Radke
authors.forename: Andreas
authors.initials: A
authors.lastname: Franke
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Blindt
authors.forename: Jan
authors.initials: J
authors.lastname: Ortlepp
authors.forename: Jeff J
authors.initials: JJ
authors.lastname: Popma
authors.forename: Christian
authors.initials: C
authors.lastname: Weber
authors.forename: Peter
authors.initials: P
authors.lastname: Hanrath
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000517:prevention & control*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011474:Prosthesis Design; D015607:Stents; D018084:Ultrasonography, Interventional
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone