Semaphorins guide PerPlexeD endothelial cells.
Abrogation of the endothelial cell-specific semaphorin receptor PlexinD1 in zebrafish and mouse reveals semaphorin functions selectively affecting the cardiovascular system. Neuropilins team up with PlexinD1 to form a novel endothelial receptor complex for class 3 semaphorins.
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Theodor-Kocher-Institute, University of Berne, Freiestrasse 1, 3012 Berne, Switzerland.
D000818:Animals; D018376:Cardiovascular Abnormalities / Q000235:genetics / Q000378:metabolism; D002319:Cardiovascular System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000002:abnormalities* / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000172:deficiency* / Q000235:genetics; D023421:Models, Animal; D009419:Nerve Tissue Proteins / Q000172:deficiency* / Q000235:genetics; D039921:Neuropilins / Q000378:metabolism; D039961:Semaphorins / Q000378:metabolism*
D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D039921:Neuropilins; C473552:Plxnd1 protein, mouse; D039961:Semaphorins