title: [Primary prevention of diabetes mellitus type 2].
abstract: The increasing incidence of type 2 diabetes constitutes a considerable individual and socio-economic risk, therefore preventive concepts are urgently needed. Three prospective studies show that a "life-style-intervention" as well as drugs can prevent the development of diabetes as well as cardiovascular complications: The Diabetes Prevention Study (DPS) evaluated the influence of a "life-style-intervention". The Diabetes Prevention Program (DPP) additionally examined the effect of metformin. In the STOP-NIDDM-Study acarbose was used for diabetes prevention and cardiovascular endpoints were also evaluated. The incidence of type 2 diabetes can be significantly reduced by a "life-style-intervention" and also by the administration of metformin or acarbose. With acarbose cardiovascular events are reduced significantly and comparably to a therapy with statins in primary prevention.
authors.affiliation: Medizinische Klinik IV, Eberhard-Karls-Universität Tübingen. baptist.gallwitz@med.uni-tuebingen.de
authors.forename: B
authors.initials: B
authors.lastname: Gallwitz
mesh_terms: D020909:Acarbose / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D005247:Feeding Behavior; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008019:Life Style; D008687:Metformin / Q000627:therapeutic use; D009765:Obesity; D011322:Primary Prevention; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin; D020909:Acarbose