title: Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection.
abstract: We show that Ugandan adults coinfected with Schistosoma mansoni and human immunodeficiency virus type 1 (HIV-1) are able to mount S. mansoni-specific immune responses but that few such responses increase after treatment with praziquantel (PZQ). Levels of soluble worm antigen (SWA)-specific immunoglobulin (Ig) G1, IgG2, IgG3, IgG4, interleukin (IL)-4, and IL-5 increased significantly in HIV-negative participants after treatment with PZQ, whereas most soluble egg antigen-specific antibody responses and levels of interferon- gamma were unaltered. Only levels of SWA-specific IL-5 increased in HIV-1-coinfected participants after treatment. These deficiencies in immune responses may account for the previously reported increased susceptibility to infection and reinfection with S. mansoni in individuals coinfected with HIV-1.
authors.affiliation: Department of Pathology, University of Cambridge, Cambridge, United Kingdom. sj122@cam.ac.uk
authors.forename: Sarah
authors.initials: S
authors.lastname: Joseph
authors.forename: Frances M
authors.initials: FM
authors.lastname: Jones
authors.forename: Maureen E
authors.initials: ME
authors.lastname: Laidlaw
authors.forename: Gamal
authors.initials: G
authors.lastname: Mohamed
authors.forename: Patrice A
authors.initials: PA
authors.lastname: Mawa
authors.forename: Proscovia B
authors.initials: PB
authors.lastname: Namujju
authors.forename: Moses
authors.initials: M
authors.lastname: Kizza
authors.forename: Christine
authors.initials: C
authors.lastname: Watera
authors.forename: James A G
authors.initials: JA
authors.lastname: Whitworth
authors.forename: David W
authors.initials: DW
authors.lastname: Dunne
authors.forename: Alison M
authors.initials: AM
authors.lastname: Elliott
mesh_terms: D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology; D016207:Cytokines / Q000378:metabolism*; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D014454:Uganda
chemical_list: D000871:Anthelmintics; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D016207:Cytokines; D011223:Praziquantel