Growth responses of Cassia obtusifolia toward human intestinal bacteria.
1,2-Dihydroxyanthraquinone (1) was isolated from the seed of Cassia obtusifolia through bioassay-guided fractionation. 1,2-Dihydroxyanthraquinone strongly inhibited the growth of Clostridium perfringens and Escherichia coli. Structure-activity relationship revealed that 1,4-dihydroxyanthraquinone (2) and 1,8-dihydroxyanthraquinone (3) had strong growth-inhibition against C. perfringens. In growth-promoting activity, 1,2-, 1,4-, and 1,8-dihydroxyanthraquinones exhibited strong growth-promoting activity to Bifidobacterium bifidum.
Sung
Bo-Kyung
BK
Institute of Bio-Safety Research and Institute of Agricultural Science and Technology, College of Agriculture, Chonbuk National University, Chonju 561-756, South Korea.
Kim
Moo-Key
MK
Lee
Wang-Hyu
WH
Lee
Dong-Heon
DH
Lee
Hoi-Seon
HS
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002366:Cassia; D003016:Clostridium perfringens / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D010936:Plant Extracts