title: Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration.
abstract: Positron emission tomography (PET) using [(11)C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [(11)C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [(11)C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.
authors.affiliation: Department of Neurology, University of Ulm, Ulm, Germany.|Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Henkel
authors.affiliation: Department of Neurology, University of Ulm, Ulm, Germany.|Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Karitzky
authors.affiliation: Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Schmid
authors.affiliation: Department of Neuroradiology, University of Tübingen, Tübingen, Germany.
authors.forename: Irina
authors.initials: I
authors.lastname: Mader
authors.affiliation: Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Glatting
authors.affiliation: Department of Neurology, University of Ulm, Ulm, Germany.
authors.forename: Jürgen W
authors.initials: JW
authors.lastname: Unger
authors.affiliation: Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Neumaier
authors.affiliation: Department of Neurology, University of Ulm, Ulm, Germany.
authors.forename: Albert C
authors.initials: AC
authors.lastname: Ludolph
authors.affiliation: Department of Nuclear Medicine, University of Ulm, Ulm, Germany.
authors.forename: Sven N
authors.initials: SN
authors.lastname: Reske
authors.affiliation: Department of Neurology, University of Ulm, Ulm, Germany.
authors.forename: G Bernhard
authors.initials: GB
authors.lastname: Landwehrmeyer
mesh_terms: D000368:Aged; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007546:Isoquinolines; D008279:Magnetic Resonance Imaging; D008297:Male; D017628:Microglia / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D009410:Nerve Degeneration / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D007546:Isoquinolines; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A; C037850:PK 11195