title: Genetic testing for alpha1-antitrypsin deficiency.
abstract: OBJECTIVE
  The Alpha Coded Testing Study investigated the risks, benefits, and psychological impact of home genetic testing for alpha1-antitrypsin deficiency.
  
  
  METHODS
  In the study, 996 adult individuals requested and returned a home-administered, confidential, fingerstick blood test.
  
  
  RESULTS
  Individuals highly rated the benefits of establishing a diagnosis (82%), helping family members (86%), and anticipating peace of mind (79%). 78% of 239 current smokers reported a high likelihood of smoking cessation if diagnosed with AATD. After testing, more than 60% indicated that they would share the results with family and physicians but < 30% would share results with insurance companies.
  
  
  CONCLUSIONS
  Confidential home testing for genetic disorders requires a comprehensive program of participant support.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA.
authors.forename: Charlie
authors.initials: C
authors.lastname: Strange
authors.forename: Ryan
authors.initials: R
authors.lastname: Dickson
authors.forename: Cindy
authors.initials: C
authors.lastname: Carter
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Carpenter
authors.forename: Brian
authors.initials: B
authors.lastname: Holladay
authors.forename: Ryan
authors.initials: R
authors.lastname: Lundquist
authors.forename: Mark L
authors.initials: ML
authors.lastname: Brantly
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005820:Genetic Testing / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D019896:alpha 1-Antitrypsin Deficiency / Q000175:diagnosis* / Q000523:psychology