Hemodynamics of microvascular dysfunction in patients with anterior wall acute myocardial infarction.
This study investigated whether the no-reflow phenomenon in acute myocardial infarction (AMI) is associated with an increase in coronary zero flow pressure (ZFP), a decrease in coronary arterial conductance, or both phenomena. Coronary blood flow velocity and pressure were measured with a Doppler guidewire and a pressure wire, respectively, during vasodilation with adenosine triphosphate after coronary intervention. The data indicate that the no-reflow phenomenon is not necessarily associated with a decrease in coronary arterial conductance but with an increase in ZFP. Greater ZFP is associated with more severe microvascular dysfunction and worse functional outcomes in patients with AMI.
Ito
Hiroshi
H
Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan. itomd@osk4.3web.ne.jp
Terai
Kazuo
K
Iwakura
Katsuomi
K
Kawase
Ichiro
I
Fujii
Kenshi
K
D001783:Blood Flow Velocity; D001794:Blood Pressure; D002200:Capillary Resistance; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D012039:Regional Blood Flow