title: Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth.
abstract: Column chromatographic fractionation of essential oil obtained by hydrodistillation from the flowering tops of S. ixiocephala resulted in the isolation of beta-caryophyllene, fenchyl acetate, T-cadinol and a new sesquiterpene alcohol for which a name ixiocephol has been proposed. The beta-caryophyllene and fenchyl acetate were identified by Co-TLC with authentic samples whereas T-cadinol and ixiocephol were structurally elucidated by UV, IR, 1H NMR, 13C NMR and Mass spectral data. The GC-MS analysis of the essential oil has also revealed the presence of various monoterpenoids and sesquiterpenoids. The essential oil of S. ixiocephala demonstrated a dose dependant anti-inflammatory activity in carrageenan-induced rat paw oedema. It has also revealed good activity in cotton pellet granuloma and adjuvant induced arthritis model in rats.
authors.affiliation: Department of Pharmacognosy, Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune 411 038, India.
authors.forename: Ramesh B
authors.initials: RB
authors.lastname: Agarwal
authors.forename: Vinod D
authors.initials: VD
authors.lastname: Rangari
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D015745:Granuloma, Foreign-Body / Q000188:drug therapy*; D008297:Male; D009822:Oils, Volatile / Q000302:isolation & purification / Q000627:therapeutic use*; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009822:Oils, Volatile