title: Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis.
abstract: The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms in the susceptibility to psoriatic arthritis. MnSOD gene polymorphisms were determined by polymerase chain reaction/restriction fragment length polymorphisms method in fifty-two patients with psoriatic arthritis and 90 healthy controls.The genotype frequency of MnSOD 1183C/T was significantly higher in patients with psoriatic arthritis than in controls. In contrast, the frequency of MnSOD 1183T/T was significantly decreased in patients with psoriatic arthritis. The phenotype frequency of MnSOD 1183C was significantly increased in patients with psoriatics arthritis in comparison to healthy controls.Therefore, MnSOD 1183C polymorphisms may be a precipitating factor for the development of psoriatic arthritis.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. jehsye@kmu.edu.tw
authors.forename: Jeng-Hsien
authors.initials: JH
authors.lastname: Yen
authors.forename: Wen-Chun
authors.initials: WC
authors.lastname: Tsai
authors.forename: Chia-Hui
authors.initials: CH
authors.lastname: Lin
authors.forename: Tsan-Teng
authors.initials: TT
authors.lastname: Ou
authors.forename: Chaur-Jong
authors.initials: CJ
authors.lastname: Hu
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Liu
mesh_terms: D015535:Arthritis, Psoriatic / Q000201:enzymology* / Q000235:genetics; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D013482:Superoxide Dismutase