title: Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes.
abstract: Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.
authors.affiliation: Cardiovascular Research Group, School of Pharmacy, The University of Reading, P.O. Box 228, Whiteknights, Reading, Berkshire RG6 6AJ, UK.
authors.forename: Katrina A
authors.initials: KA
authors.lastname: Bicknell
authors.forename: Carmen H
authors.initials: CH
authors.lastname: Coxon
authors.forename: Gavin
authors.initials: G
authors.lastname: Brooks
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000502:physiology*; D049109:Cell Proliferation; D019926:Cyclin B / Q000502:physiology*; D056744:Cyclin B1; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D008297:Male; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C534701:Ccnb1 protein, rat; D019926:Cyclin B; D056744:Cyclin B1; D016203:CDC2 Protein Kinase