title: Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus.
abstract: The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s<0.1 microM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.
authors.affiliation: Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. digranm@wyeth.com
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Di Grandi
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Curran
authors.forename: Gregg
authors.initials: G
authors.lastname: Feigelson
authors.forename: Amar
authors.initials: A
authors.lastname: Prashad
authors.forename: Adma A
authors.initials: AA
authors.lastname: Ross
authors.forename: Robert
authors.initials: R
authors.lastname: Visalli
authors.forename: Jeanette
authors.initials: J
authors.lastname: Fairhurst
authors.forename: Boris
authors.initials: B
authors.lastname: Feld
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Bloom
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D013890:Thiourea