Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of 2-azaanthraquinones.
As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the standard redox potentials of some 2-azaanthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the 2-azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has been further shown that the correlation can be enhanced by introducing an electronic properties, i.e. the atomic charges at the C5 and O12 atoms in the quinone skeleton ring and the HOMO energy as additional parameters.
Koyama
Junko
J
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658-8558, Japan. j-koyama@kobepharma-u.ac.jp
Morita
Izumi
I
Kobayashi
Norihiro
N
Osakai
Toshiyuki
T
Hotta
Hiroki
H
Takayasu
Junko
J
Nishino
Hoyoku
H
Tokuda
Harukuni
H
D000880:Anthraquinones / Q000494:pharmacology*; D000956:Antigens, Viral / Q000494:pharmacology*; D004594:Electrophysiology; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
D000880:Anthraquinones; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen