title: Subsets of T cells in healthy rhesus macaques (Macaca mulatta) infected with simian T-lymphotropic virus type 1.
abstract: Simian T-lymphotropic virus type 1 (STLV-1) is a C-type retrovirus of nonhuman primates that is genetically and antigenically related to human T-lymphotropic virus type 1 (HTLV-1). Infection with STLV-1 has been reported in many species of Old World monkeys and apes, including rhesus macaques (Macaca mulatta). Similar to HTLV infection in humans, STLV infection has been associated with T-cell lymphoproliferative disease or lymphoma in a small proportion of infected animals, predominantly African species. There are conflicting reports of T-cell subset alterations in healthy HTLV-1 carriers. To the authors' knowledge, analysis of T-cell subsets in healthy STLV-1 carrier rhesus macaques has not been reported. Subsets of T cells in peripheral blood from healthy, STLV-1-seropositive rhesus macaques (n = 17) and seronegative controls matched for age and sex (n = 17) were determined by use of fluorescence-activated cell sorter analysis. Parameters measured included CD3, CD4, CD8, CD25, CD28, CD38, and HLA-DR cell sets. Significant differences in T-cell subsets or hematologic parameters were not observed between healthy STLV-seropositive and seronegative groups.
authors.affiliation: California National Primate Research Center, University of California, Davis 95616, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Brignolo
authors.forename: Abigail
authors.initials: A
authors.lastname: Spinner
authors.forename: JoAnn L
authors.initials: JL
authors.lastname: Yee
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Lerche
mesh_terms: D000818:Animals; D002353:Carrier State; D006800:Deltaretrovirus Infections / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015303:Simian T-lymphotropic virus 1; D016176:T-Lymphocyte Subsets / Q000276:immunology*