title: A new environment-sensitive fluorescent amino acid for Fmoc-based solid phase peptide synthesis.
abstract: A new 4-(N,N-dimethylamino) phthalimide-based environment-sensitive fluorescent building block for solid phase peptide synthesis, has been synthesized and incorporated into peptides. Peptides incorporating this residue show great potential for biological applications in sensing protein/protein interactions.
authors.affiliation: Departments of Chemistry and Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: M
authors.initials: M
authors.lastname: Eugenio Vazquez
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Rothman
authors.forename: Barbara
authors.initials: B
authors.lastname: Imperiali
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C492935:4-(N,N-dimethylamino) phthalimide; D000596:Amino Acids; D005449:Fluorenes; D005456:Fluorescent Dyes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides; D010797:Phthalimides