[Liberation of hydrocortisone acetate from different commercial formulations].
Liberation of hydrocortisone acetate from different commercial formulations In this article the release of hydrocortisone acetate (HC-acetate) from three commercial semisolid formulations (Ebeno-ointment, Soventol HC cream and Fenistil hydrocortisone ointment) was measured by means of a multilayer membrane system (MLMS) described in the literature. The formulations are different regarding rate and extent of the release of HC-acetate. The release of HC-acetate form the Soventol HC cream is very fast and results in high topical availability. In contrast, HC-acetate shows a sustained release from the Fenistil hydrocortisone ointment. The release of HC-acetate from the Ebenol-ointment is between that of the Soventol HC cream and that of the Fenistil-ointment. In summary, HC-acetate shows a shorter mean liberation time (MDT) and a higher topical availability from Soventol HC cream in comparison to the other formulations studied.
Neubert
R H H
RH
Fachbereich Pharmazie, Institut für Pharmazeutische Technologie und Biopharmazie der Martin-Luther-Universität, Halle-Wittenberg, Germany. neubert@pharmazie.uni-halle.de
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D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000032:analysis*; D019540:Area Under Curve; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D005079:Excipients; D006854:Hydrocortisone / Q000008:administration & dosage / Q000032:analysis*; D008567:Membranes, Artificial; D009824:Ointments; D010539:Permeability; D012997:Solvents
D000893:Anti-Inflammatory Agents; D005079:Excipients; D008567:Membranes, Artificial; D009824:Ointments; D012997:Solvents; D006854:Hydrocortisone