Synergic activity of selenium and probiotic bacterium Enterococcus faecium M-74 against selected mutagens in Salmonella assay.
Concentrated extracts of MRS (De Man-Rogosa-Sharpe) media in which probiotic bacterium Enterococcus faecium strain M-74 was grown exerted different antimutagenic activity against ofloxacin-, N-methyl, N'-nitro-N-nitrosoguanidine- and sodium 5-nitro-2-furylacrylate-induced mutagenicity in Salmonella typhimurium assay depending on the presence (+Se) or absence of disodium selenite pentahydrate (-Se). The antimutagenicity of MRS(+Se) extract was higher than that of MRS(-Se) extract. Selenium enhanced also the antimutagenic effect of both live and killed cells of E. faecium M-74, respectively. The live bacteria decreased the mutagenicity of selected substances more than killed cells. Synergic activity of selenium with the bacterium was also manifested.
Belicová
A
A
Institute of Cell Biology, Faculty of Science, Comenius University, 811 07 Bratislava, Slovakia. belicova@m2.fedu.uniba.sk
Krizková
L
L
Dobias
J
J
Krajcovic
J
J
Ebringer
L
L
D016587:Antimutagenic Agents / Q000494:pharmacology; D004357:Drug Synergism; D016984:Enterococcus faecium / Q000378:metabolism / Q000502:physiology*; D016296:Mutagenesis / Q000187:drug effects*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D019936:Probiotics / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D012643:Selenium / Q000494:pharmacology*
D016587:Antimutagenic Agents; D009153:Mutagens; D012643:Selenium