Myorelaxant and antispasmodic effects of the aqueous extract of Mitragyna inermis barks on Wistar rat ileum.
Mitragyna inermis is used in the Senegal traditional medicine for treating stomach and intestinal disorders. At concentrations of 0.5, 0.75 and 1 mg/ml, the aqueous extract of M. inermis bark (AEMIB) significantly induced a decrease of the ileal basal tonus, respectively, from 37+/-1, 51+/-1 and 75+/-2% (P<0.05; n=5), compared to the baseline values. As well as atropine, AEMIB inhibited submaximal contractions induced by 0.01 mg/ml ACh with IC(50) value of approximately 0.75 mg/ml (n=5). These results show that AEMIB possesses both myorelaxant and antispasmodic actions in the ileum. This may justify the pharmacological basis for the popular use of Mitragyna for the treatment of gastrointestinal disorders.
Sy
Guata Yoro
GY
Laboratoire de Pharmacologie, Faculté de Médecine et Pharmacie, Université Cheikh Anta Diop, Dakar, Senegal. guata-yoro.sy@ulp.u-strasbg.fr
Sarr
Aminata
A
Dièye
Amadou Moctar
AM
Faye
Babacar
B
D000109:Acetylcholine; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007082:Ileum / Q000187:drug effects*; D008297:Male; D032065:Mitragyna; D009119:Muscle Contraction / Q000187:drug effects*; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D010276:Parasympatholytics; D010936:Plant Extracts; D000109:Acetylcholine