title: Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression.
abstract: Although the central role of ANG II in cardiovascular homeostasis is well appreciated, the molecular circuitry of its many actions is not completely understood. With the use of serial analysis of gene expression to assess global transcriptional changes in the heart of mice after continuous 7-day ANG II administration, we identified patterns of gene expression indicative of cardiac remodeling, including coordinate regulation of genes previously described in a context of processes associated with hypertrophy and fibrosis. In addition, we discovered several novel ANG II targets, including characterized genes of known function, recently annotated genes of unknown function, and the putative genes not yet present in current databases. The serial analysis of gene expression approach to assess the role of ANG II presented in this report provides new venues for inquiries into ANG II-mediated cardiac function.
authors.affiliation: Dept. of Medicine, Genetics Program, Boston Univ. School of Medicine, 715 Albany St., L-320, Boston, MA 02118, USA. fschw@bu.edu
authors.forename: Faina
authors.initials: F
authors.lastname: Schwartz
authors.forename: Arvi
authors.initials: A
authors.lastname: Duka
authors.forename: Irena
authors.initials: I
authors.lastname: Duka
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.forename: Haralambos
authors.initials: H
authors.lastname: Gavras
mesh_terms: D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D015870:Gene Expression / Q000502:physiology*; D020869:Gene Expression Profiling / Q000379:methods*; D016678:Genome; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014158:Transcription, Genetic
chemical_list: D000804:Angiotensin II