title: New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization.
abstract: The functionalization of an oligonucleotide by flavin and deazaflavin derivatives allowed an amperometric determination of the hybridization process through the disappearance of the electroactivity of the free oligonucleotide and the appearance of a new electrochemical signal characteristic of the resulting duplex.
authors.affiliation: Laboratoire d'Electrochimie Organique et de Photochimie Rédox UMR 5630 CNRS Institut de Chimie Moléculaire de Grenoble FR CNRS 2607, Université Joseph Fourier, BP 53, 38041 Grenoble 9, France. serge.cosnier@ujf-grenoble.fr
authors.forename: Serge
authors.initials: S
authors.lastname: Cosnier
authors.forename: Chantal
authors.initials: C
authors.lastname: Gondran
authors.forename: Cécile
authors.initials: C
authors.lastname: Dueymes
authors.forename: Philippe
authors.initials: P
authors.lastname: Simon
authors.forename: Marc
authors.initials: M
authors.lastname: Fontecave
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Décout
mesh_terms: D001483:Base Sequence; D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D004563:Electrochemistry / Q000379:methods*; D005415:Flavins / Q000737:chemistry*; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*
chemical_list: D015342:DNA Probes; D005415:Flavins; D009838:Oligodeoxyribonucleotides; D004247:DNA