title: [Hypothalamic-infundibular histiocytosis: magnetic resonance findings].
abstract: BACKGROUND
  We report the magnetic resonance imaging (MRI) of a case of Langerhans cell histiocytosis in the pituitary. Isolated central nervous system involvement is uncommon.
  
  
  METHODS
  An eighteen-years old female patient who had an acute onset of central diabetes insipidus because of the Langerhans cell histiocytosis. The MRI evidenced a lesion in the hypothalamic-pituitary axis. The hyperintensity in the posterior pituitary lobe, which is seen in normal subjects on T1-weighted images, was absent. The pituitary stalk was thickened and enhanced homogeneously following contrast administration. During the follow-up, the infundibullar lesion extended to the hypothalamic region and other systemic manifestations appeared. Diagnosis of Langerhans cell histiocytosis was confirmed by lung biopsy. After radiotherapy and chemotherapy, MRI showed regression of the hypothalamic-pituitary lesion.
  
  
  CONCLUSIONS
  The combination of these findings, although nonspecific of Langerhans cell histiocytosis, should nevertheless prompt further studies, including chest films, bone scanning and temporal bone computerized tomography in order to narrow the differential diagnosis.
authors.affiliation: Servicio de Radiodiagnóstico, Sección de Neurorradiología, Hospital Universitario Miguel Servet, Zaragoza, Spain. acrespor@salud.aragob.es
authors.forename: A M
authors.initials: AM
authors.lastname: Crespo-Rodríguez
authors.forename: C
authors.initials: C
authors.lastname: Franco
authors.forename: M C
authors.initials: MC
authors.lastname: Lidón
authors.forename: B
authors.initials: B
authors.lastname: Izquierdo
authors.forename: E
authors.initials: E
authors.lastname: Angulo
authors.forename: L V
authors.initials: LV
authors.lastname: Mazas-Artasona
mesh_terms: D000293:Adolescent; D003919:Diabetes Insipidus / Q000209:etiology; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007031:Hypothalamus / Q000473:pathology*; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000473:pathology*