A Role for the RSC chromatin remodeler in regulating cohesion of sister chromatid arms.
The precise segregation of chromosomes is critical for the proliferation and development of living organisms. Defects in this process can result in tumorigenesis and hereditary diseases. The four-subunit cohesin complex plays an essential role in chromosome segregation and genome integrity. Recently, we reported that the association of cohesin with centromeres and chromosome arms is differentially regulated by the ATP-dependent RSC chromatin-remodeling complex. Here, we propose two models to explain why the cell should have evolved special mechanisms for centromeric and sister arm cohesion and why RSC differentially regulates these processes.
Huang
Jian
J
Program in Molecular and Cellular Biology, Department of Microbiology and Immunology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA.
Laurent
Brehon C
BC
D000818:Animals; D002842:Chromatids / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D008957:Models, Genetic; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D012854:Sister Chromatid Exchange / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; C103337:RSC complex, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors