title: Risk factor for extrahepatic bile duct cancer in patients with anomalous pancreaticobiliary ductal union.
abstract: OBJECTIVE
  Anomalous connection between the choledochus and pancreatic duct is considered to be a factor in the development of biliary tract diseases such as choledochal cyst, pancreatitis, cholangitis, gallbladder cancer, and bile duct cancer. Our purpose was analysis of combined disease, especially biliary neoplasm and evaluated microscopic changes of extrahepatic bile ducts.
  
  
  METHODS
  To study the clinical characteristics of anomalous pancreaticobiliary ductal union (APBDU), we reviewed 14 APBDU cases from June 1994 to June 1998. We studied the associated disease, surgical treatment, and the histological findings of the extrahepatic bile ducts.
  
  
  RESULTS
  Gallbladder cancer was identified in 5 out of 14 patients with APBDU. The incidences of metaplasia of gallbladder and bile duct with APBDU were higher than that of control gallbladder epithelium. The proliferating cell nuclear antigen-labeling index of the gallbladder in patients with APBDU was significantly higher than that in the control group.
  
  
  CONCLUSIONS
  The patients with APBDU showed high incidence of gallbladder carcinoma and metaplasia in epithelium of gallbladder and bile duct. As this metaplasia in the gallbladder and bile duct is thought of as a precancerous condition, it is important to remove the place that causes bile stasis and to stop backflow of pancreatic juice into the bile duct in managing patients with this anomaly. In other words, prophylactic cholecystectomy and reconstruction of the biliary tract are both necessary.
authors.affiliation: Department of Surgery, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Yong-Sik
authors.initials: YS
authors.lastname: Jung
authors.forename: Kuk-Jong
authors.initials: KJ
authors.lastname: Lee
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Wook-Hwan
authors.initials: WH
authors.lastname: Kim
authors.forename: In-Gyu
authors.initials: IG
authors.lastname: Kim
authors.forename: Byeong-Moo
authors.initials: BM
authors.lastname: Yoo
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Myung-Wook
authors.initials: MW
authors.lastname: Kim
mesh_terms: D000015:Abnormalities, Multiple / Q000601:surgery; D001649:Bile Duct Diseases / Q000473:pathology; D001650:Bile Duct Neoplasms / Q000209:etiology*; D017734:Bile Ducts, Extrahepatic / Q000473:pathology; D001659:Biliary Tract / Q000473:pathology; D002455:Cell Division; D002763:Cholecystectomy; D003135:Common Bile Duct / Q000002:abnormalities*; D003560:Cysts / Q000473:pathology; D005260:Female; D005706:Gallbladder Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D006801:Humans; D015994:Incidence; D008297:Male; D008679:Metaplasia; D010183:Pancreatic Ducts / Q000002:abnormalities*; D011230:Precancerous Conditions / Q000453:epidemiology / Q000209:etiology; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D018809:Proliferating Cell Nuclear Antigen