Warfarin and the vitamin K-dependent gamma-carboxylation system.
Insight into the molecular basis for genetic warfarin resistance has recently been accomplished by the identification of an 18-kDa protein of the endoplasmic reticulum that is targeted by the drug. When expressed in eukaryotic and insect cells, the protein reduces vitamin K1 2,3-epoxide in a warfarin-sensitive reaction. This finding strongly suggests that the protein is part of the vitamin K cycle, which is essential for the production of vitamin K-dependent proteins. Identification of the 18-kDa protein has aided the understanding of the vitamin K-dependent gamma-carboxylation system at the molecular level.
Wallin
Reidar
R
Departments of Internal Medicine and Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. rwallin@wfubmc.edu
Hutson
Susan M
SM
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D019735:Carbon-Carbon Ligases / Q000378:metabolism; D004351:Drug Resistance / Q000235:genetics; D004721:Endoplasmic Reticulum / Q000737:chemistry; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D008970:Molecular Weight; D014812:Vitamin K / Q000378:metabolism*; D064417:Vitamin K Epoxide Reductases; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D008565:Membrane Proteins; D014812:Vitamin K; D014859:Warfarin; D006899:Mixed Function Oxygenases; D064417:Vitamin K Epoxide Reductases; D019735:Carbon-Carbon Ligases; C020660:glutamyl carboxylase