Links between apoptosis, proliferation and the cell cycle.
Many physiological processes, including proper tissue development and homeostasis, require a balance between apoptosis and cell proliferation. All somatic cells proliferate via a mitotic process determined by progression through the cell cycle. Apoptosis (programmed cell death) occurs in a wide variety of physiological settings, where its role is to remove harmful, damaged or unwanted cells. Apoptosis and cell proliferation are linked by cell-cycle regulators and apoptotic stimuli that affect both processes. This review covers recent developments in the field and examines new evidence of the interconnection between apoptosis and cell proliferation.
Alenzi
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FQ
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, King Faisal University, P.O. Box 2114, Dammam 31451, Saudi Arabia. faris_alenzi@hotmail.com
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D006801:Humans; D051379:Mice
D018797:Cell Cycle Proteins