title: Limited infection upon human exposure to a recombinant raccoon pox vaccine vector.
abstract: A laboratory accident resulted in human exposure to a recombinant raccoon poxvirus (RCN) developed as a vaccine vector for antigens of Yersinia pestis for protection of wild rodents (and other animals) against plague. Within 9 days, the patient developed a small blister that healed within 4 weeks. Raccoon poxvirus was cultured from the lesion, and the patient developed antibody to plague antigen (F1) and RCN. This is the first documented case of human exposure to RCN.
authors.affiliation: USGS National Wildlife Health Center, 6006 Schroeder Road, Madison, WI 53711, USA. tonie_rocke@usgs.gov
authors.forename: Tonie E
authors.initials: TE
authors.lastname: Rocke
authors.forename: F Joshua
authors.initials: FJ
authors.lastname: Dein
authors.forename: Martina
authors.initials: M
authors.lastname: Fuchsberger
authors.forename: Barry C
authors.initials: BC
authors.lastname: Fox
authors.forename: Dan T
authors.initials: DT
authors.lastname: Stinchcomb
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Osorio
mesh_terms: D000062:Accidents, Occupational; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D005260:Female; D005822:Genetic Vectors; D006801:Humans; D007753:Laboratories; D051379:Mice; D010930:Plague / Q000276:immunology; D011212:Poxviridae / Q000276:immunology*; D011213:Poxviridae Infections / Q000276:immunology*; D011821:Raccoons; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019444:Vaccines, DNA / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D015010:Yersinia pestis / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic; D014765:Viral Vaccines