title: Enantioseparation of tiropramide by HPLC.
abstract: Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.
authors.affiliation: Department of Chemistry, Graduate School, Kyungpook National University, 702-701 Daegu, Korea. jjryoo@iastate.edu
authors.forename: Jae Jeong
authors.initials: JJ
authors.lastname: Ryoo
authors.forename: Kyu Sung
authors.initials: KS
authors.lastname: Heo
authors.forename: Eun-Soon
authors.initials: ES
authors.lastname: Choi
authors.forename: Jung Hag
authors.initials: JH
authors.lastname: Park
authors.forename: Wonjae
authors.initials: W
authors.lastname: Lee
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D010276:Parasympatholytics / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D010276:Parasympatholytics; D014443:Tyrosine; C031173:tiropramide