Virucidal activity of the new disinfectant monopercitric acid.
OBJECTIVE
The virucidal efficacy of monopercitric acid (MPCA) was evaluated against the enveloped vaccinia virus as well as the nonenveloped adenovirus type 2 and poliovirus type 1. The results were compared with that obtained with peracetic acid (PAA).


RESULTS
In the virucidal suspension test without and with protein burden, all viruses were inactivated by 0.5% MPCA within 0.5 min or by 0.1% MPCA within 5 min as measured by a >10(4)-fold reduction in virus titres. For MPCA, there was a better virucidal efficacy than for PAA which inactivated all viruses included in the test within 15-30 min at a concentration of 0.2%.


CONCLUSIONS
The high virucidal activity, short exposure times, and nontoxic by-products seem to make MPCA suitable as disinfectant for medical use and should warrant further investigation.
Wutzler
P
P
Institute of Virology and Antiviral Therapy, Friedrich-Schiller University, Jena, Germany.
Sauerbrei
A
A
D000256:Adenoviridae / Q000187:drug effects; D000998:Antiviral Agents / Q000494:pharmacology*; D002951:Citrates / Q000737:chemistry / Q000494:pharmacology*; D004202:Disinfectants / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010463:Peracetic Acid / Q000494:pharmacology; D017955:Poliovirus / Q000187:drug effects; D014616:Vaccinia virus / Q000187:drug effects; D014780:Viruses / Q000737:chemistry / Q000187:drug effects
D000998:Antiviral Agents; D002951:Citrates; D004202:Disinfectants; C491686:monopercitric acid; D010463:Peracetic Acid