title: The interface between cell and developmental biology.
abstract: Cell differentiation, morphology, migration, polarity, intercellular communication and adhesion are all cellular processes that control embryo morphogenesis and lie at the interface of cell and developmental biology. The interface between these two fields is best illustrated, however, in studies of axiation and cytoskeletal remodeling during development. Recent advances reveal novel mechanisms for axiation, including the role of RNA and protein degradation in regulating the timely expression of morphogenetic signals. Significant progress has also been made in identifying components of the cytoskeleton and the extracellular matrix that mediate embryonic cell migration and polarity. Cellular processes at the interface of cell and developmental biology are overseen by the Wnt signaling cascade that coordinates both axiation and cytoskeletal remodeling during development.
authors.affiliation: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 21st Avenue South, U-4200 MCN Learned Laboratories, Nashville, Tennessee 37232-2175, USA.
authors.forename: Emilios
authors.initials: E
authors.lastname: Tahinci
authors.forename: Ethan
authors.initials: E
authors.lastname: Lee
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000502:physiology*; D009024:Morphogenesis; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins