Correlation of neuron-specific enolase and S100B with histological cerebral damage in fetal sheep after severe asphyxia.
Experimental brain damage was induced in 16 fetal sheep by umbilical cord occlusion, and the correlation of neuron-specific enolase (NSE) or S100B with the damage grade was investigated in seven fetuses. Significant correlations of damage degree with NSE (p = 0.016) and S100B (p = 0.018) in serum 2 h after insult were shown by Spearman's test. These findings suggest that they represent potentially useful markers for detecting brain damage at early stage after ischemic insult.
Fujii
Eriko Y
EY
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Japan. fujii-e@ncchd.go.jp
Kozuki
Masatomo
M
Mu
Junwu
J
Ino
Yukiko
Y
Ushioda
Norichika
N
Tomimatsu
Takuya
T
Fukuda
Hirotsugu
H
Kanzaki
Toru
T
Nakayama
Masahiro
M
Murata
Yuji
Y
D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D001921:Brain / Q000196:embryology / Q000378:metabolism* / Q000473:pathology; D003251:Constriction, Pathologic; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000502:physiology; D005311:Fetal Hypoxia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D005333:Fetus; D002534:Hypoxia, Brain / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D015588:Observer Variation; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D015203:Reproducibility of Results; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism*; D012756:Sheep; D014470:Umbilical Cord / Q000503:physiopathology; D015854:Up-Regulation / Q000502:physiology
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase