Free radical scavenging potential of Picrorhiza kurrooa Royle ex Benth.
For assessing free radical scavenging potential of P. kurrooa, the antioxidant activity of P. kurrooa extract was studied by lipid peroxidation assay using rat liver homogenate. The extract (1 mg/ml) showed marked protection (up to 66.68%) against peroxidation of liver phospholipids. Besides, reduced glutathione showed very encouraging activity. The extract also exhibited significant scavenging activity. Thus augmenting the wide use of plant in the indigenous system of medicine, which may partly be due to antioxidant and free radical scavening activity of the extract.
Govindarajan
R
R
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226 001, India.
Vijayakumar
M
M
Rawat
A K S
AK
Mehrotra
Shanta
S
D000818:Animals; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D016877:Oxidants / Q000633:toxicity; D032261:Picrorhiza / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D016166:Free Radical Scavengers; D005609:Free Radicals; D016877:Oxidants; D010936:Plant Extracts; D005978:Glutathione