Neuronal localization of simian varicella virus DNA in ganglia of naturally infected African green monkeys.
In situ hybridization analysis of monkey ganglia 2 months after natural infection with simian varicella virus (SVV) revealed SVV DNA only in neurons. These findings parallel the detection of varicella zoster virus in neurons of latently infected human ganglia. Natural exposure to SVV provides a model system to study varicella latency.
Kennedy
Peter G E
PG
Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, Scotland, UK. P.G.Kennedy@clinmed.gla.ac.uk
Grinfeld
Esther
E
Traina-Dorge
Vicki
V
Gilden
Donald H
DH
Mahalingam
Ravi
R
D000818:Animals; D001483:Base Sequence; D002522:Chlorocebus aethiops; D017931:DNA Primers; D004279:DNA, Viral / Q000378:metabolism*; D005724:Ganglia / Q000166:cytology / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000235:genetics*; D009474:Neurons / Q000821:virology*
D017931:DNA Primers; D004279:DNA, Viral