Movement disorders and AIDS: a review.
Movement disorders are a potential neurologic complication of acquired immune deficiency syndrome (AIDS), and may sometimes represent the initial manifestation of HIV infection. Dopaminergic dysfunction and the predilection of HIV infection to affect subcortical structures are thought to underlie the development of movement disorders such as parkinsonism in AIDS patients. In this review, we will discuss the clinical presentations, etiology and treatment of the various AIDS-related hypokinetic and hyperkinetic movement disorders, such as parkinsonism, chorea, myoclonus and dystonia. This review will also summarize current concepts regarding the pathophysiology of parkinsonism in HIV infection.
Tse
Winona
W
Department of Neurology, Mount Sinai Medical Center, One Gustave L. Levy Place, Box 1052, New York, NY 10029, USA. winonatse@hotmail.com
Cersosimo
Maria G
MG
Gracies
Jean-Michel
JM
Morgello
Susan
S
Olanow
C Warren
CW
Koller
William
W
D015526:AIDS Dementia Complex / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D009069:Movement Disorders / Q000503:physiopathology* / Q000821:virology*