title: Serum nitrate levels as an index of endothelial function in pre-eclamsia and normal pregnancy.
abstract: The study was conducted in St. John's Medical College Hospital and Department of Physiology, with the aim of studying the serum nitrate levels in pre-eclampsia and normal pregnancy. The total number of subjects studied in various groups were 159, control (n = 55), first trimester (n = 13), second trimester normal (n = 42), second trimester pre-eclampsia/PET (n = 5), third trimester normal (n = 32), third trimester pre-eclampsia/PET (n = 12). The serum nitrate was measured by one step enzymatic assay using Nitrate reductase from Aspergillus species. The nitrate levels in the third trimester pre-eclamptic group was found to be significant lower (P = 0.02), as compared to normal subjects, however the renal functions were normal in all the subjects.
authors.affiliation: Department of Physiology, St. John's Medical College and Hospital, Bangalore.
authors.forename: Rani
authors.initials: R
authors.lastname: Gupta
authors.forename: K N
authors.initials: KN
authors.lastname: Maruthy
authors.forename: Arun M
authors.initials: AM
authors.lastname: Mhaskar
authors.forename: Laxmi Devi
authors.initials: LD
authors.lastname: Padmanabhan
mesh_terms: D000328:Adult; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D009566:Nitrates / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011446:Prospective Studies
chemical_list: D009566:Nitrates