title: [Amoxicillin in tonsillectomy: preliminary data on the evaluation of serum and tissue concentrations].
abstract: Amoxicillin was administered to 50 patients with chronic recurrent tonsillitis waiting for tonsillectomy. Group A (N=16) received 2.2 g of amoxicillin plus clavulanic acid with intravenous injection 10 minutes before tonsillectomy Group B (N=34) was treated with 3 doses of amoxicillin-clavulanic acid administered orally the day before surgery, plus one oral administration 2 hours before tonsillectomy. Antibiotic doses were established on patient's weight using maximum suggested. The measures were, estimated in serum and in tonsils using High Performance Liquid Chromatography, (HPLC). The data show better efficacy of intravenous administration than oral administration.
authors.affiliation: Clinica Otorinolaringoiatrica, Università degli Studi del Piemonte Orien- tale Amedeo Avogadro, Novara.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Averono
authors.forename: Massimo
authors.initials: M
authors.lastname: Olina
authors.forename: Matteo
authors.initials: M
authors.lastname: Basile
authors.forename: Marco
authors.initials: M
authors.lastname: Bagnati
authors.forename: Alessia
authors.initials: A
authors.lastname: Uglietti
authors.forename: Pietro Luigi
authors.initials: PL
authors.lastname: Garavelli
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bellomo
authors.forename: Francesco
authors.initials: F
authors.lastname: Pia
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019072:Antibiotic Prophylaxis / Q000379:methods; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014018:Tissue Distribution; D014068:Tonsillectomy; D014069:Tonsillitis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D000658:Amoxicillin