title: Electron beam therapy with coil-generated magnetic fields.
abstract: This paper presents an initial study on the issues involved in the practical implementation of the use of transverse magnetic fields in electron beam therapy. By using such magnetic fields the dose delivered to the tumor region can increase significantly relative to that deposited to the healthy tissue. Initially we calculated the magnetic fields produced by the Helmholtz coil and modified Helmholtz coil configurations. These configurations, which can readily be used to generate high intensity magnetic fields, approximate the idealized magnetic fields studied in our previous publications. It was therefore of interest to perform a detailed study of the fields produced by these configurations. Electron beam dose distributions for 15 MeV electrons were calculated using the ACCEPTM code for a 3T transverse magnetic field produced by the modified Helmholtz configuration. The dose distribution was compared to those obtained with no magnetic field. The results were similar to those obtained in our previous work, where an idealized step function magnetic field was used and a 3T field was shown to be the optimal field strength. A simpler configuration was also studied in which a single external coil was used to generate the field. Electron dose distributions are also presented for a given geometry and given magnetic field strength using this configuration. The results indicate that this method is more difficult to apply to radiotherapy due to its lack of symmetry and its irregularity. For the various configurations dealt with here, a major problem is the need to shield the magnetic field in the beam propagation volume, a topic that must be studied in detail.
authors.affiliation: Medical Physics Unit, Radiation Oncology Department, Sheba Medical Center, Ramat-Gan, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Nardi
authors.forename: Gideon
authors.initials: G
authors.lastname: Barnea
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Ma
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D004583:Electrons / Q000627:therapeutic use*; D006801:Humans; D008280:Magnetics; D009369:Neoplasms / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000379:methods / Q000706:statistics & numerical data