title: [Histopathologic study on cyclocryotherapy of human and monkey eyes].
abstract: OBJECTIVE
  To evaluate the lesion and repair process of the ciliary body and adjacent tissues in glaucomatous human eyes and normal monkey eyes with cyclocryotherapy.
  
  
  METHODS
  We used light and electron microscopy to observe the ciliary body and adjacent tissues in five glaucomatous human eyes and five normal monkey eyes which were given cyclocryotherapy.
  
  
  RESULTS
  Five absolute glaucomatous eyes were given cyclocryotherapy from one and a half to 3 years before the enucleation. One eye had no coagulated spots on the ciliary process, but five eyes had coagulated spots on the pars plana. The pigment epithelial cells were atrophic or had disappeared, but non-pigment epithelial cells had proliferated by one or two layers. At the lesion of monkey pars plicata cyclocryotherapy up to three months, melanophage phagocytosed pigment epithelium and melanocytes accumulated, although the proliferation of non-pigment epithelial cells was seen. At the lesion of monkey pars plana cyclocryotherapy melanophage accumulation was also marked, although non-pigment epithelial proliferation was greater than in pars plicata cyclocryotherapy.
  
  
  CONCLUSIONS
  As cyclocryotherapy is a blind therapy, it is uncertain and difficult to destroy the ciliary process precisely. The repair process continued up to three months after monkey cyclocryotherapy, but it took up to one year and 6 months after human cyclocryotherapy.
authors.affiliation: Department of Ophthalmology, National Defense Medical College, Tokorazawa, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kawase
authors.forename: Shigekuni
authors.initials: S
authors.lastname: Okisaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizukawa
authors.forename: Akira
authors.initials: A
authors.lastname: Murakami
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002924:Ciliary Body / Q000473:pathology / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure*; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D008252:Macaca fascicularis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012038:Regeneration; D013997:Time Factors