Hemorheological disorders and arteriolar resistance during ischemic heart disease.
It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, with a technique that provided us with the direct and quantitative data. Simultaneously we investigated in the same patients the tone of the resistance arteries of the hand with an original non-invasive technique. We found that the erythrocyte aggregability increased almost twice in the blood of investigated patients as compared to the healthy control group. The aggregability was positively correlated with severity of the disease. The most pronounced hemorheological disorders were found in the patients with the heart failure. As to the arteriolar resistance index, it was increased only in 45 percent of all the investigated patients and no significant difference between the patients with the heart failure and without it was found available. We concluded that the blood rheological disorders represent themselves a factor that plays a significant role in pathogenesis of development of the heart disease.
Urdulashvili
T
T
Microcirculation Research Center, I. Beritashvili Institute of Physiology, Tbilisi, Georgia.
Momtselidze
N
N
Mantskava
M
M
Narsia
N
N
McHedlishvili
G
G
D000787:Angina Pectoris / Q000097:blood / Q000503:physiopathology; D001160:Arterioles / Q000503:physiopathology*; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology; D018056:Hemorheology; D006801:Humans; D017202:Myocardial Ischemia / Q000097:blood* / Q000145:classification / Q000503:physiopathology; D010974:Platelet Aggregation; D012016:Reference Values; D014655:Vascular Resistance / Q000502:physiology*