title: Nuclear receptors and disease: androgen receptor.
abstract: The death of cells by apoptosis is a fundamental event in development and the maintenance of cell homoeostasis. The other side of the coin, however, is that excessive cell death by apoptosis or the lack of apoptosis is often the driving force of many diseases. Whereas reduced apoptosis sensitivity is a basic characteristic of many tumour cells, accelerated tissue cell death and loss of tissue functions is the underlying cause of many auto-immune and inflammatory diseases.
authors.affiliation: Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montréal, Québec, Canada H3T 2E1. bruce.gottlieb@mcgill.ca
authors.forename: Bruce
authors.initials: B
authors.lastname: Gottlieb
authors.forename: Lenore K
authors.initials: LK
authors.lastname: Beitel
authors.forename: Jianhui
authors.initials: J
authors.lastname: Wu
authors.forename: Youssef A
authors.initials: YA
authors.lastname: Elhaji
authors.forename: Mark
authors.initials: M
authors.lastname: Trifiro
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D010641:Phenotype; D011944:Receptors, Androgen / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000235:genetics / Q000502:physiology
chemical_list: D011944:Receptors, Androgen; D018160:Receptors, Cytoplasmic and Nuclear