HIV type 1 and cytomegalovirus coinfection in the female genital tract.
The relationship between human immunodeficiency virus (HIV) type 1 and human cytomegalovirus (CMV) was studied in blood, saliva, and cervicovaginal lavage (CVL) specimens from 33 HIV-1-infected women. An association between HIV-1 RNA and CMV DNA was found in the CVL specimens, which also were tested for cytokine levels. Women with detectable CMV DNA in CVL specimens were more likely to have higher interleukin (IL)-1 beta and IL-8 levels than were women with undetectable CMV DNA in CVL specimens. More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression.
Lurain
Nell S
NS
Rush University Medical Center, Chicago, Illinois 60612, USA. nlurain@rush.edu
Robert
Emmanuel S
ES
Xu
Jiahong
J
Camarca
Margaret
M
Landay
Alan
A
Kovacs
Andrea A
AA
Reichelderfer
Patricia S
PS
D000328:Adult; D002584:Cervix Uteri / Q000821:virology; D015331:Cohort Studies; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis / Q000097:blood; D005260:Female; D005831:Genital Diseases, Female / Q000821:virology*; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D012367:RNA, Viral / Q000032:analysis / Q000097:blood; D012463:Saliva / Q000821:virology; D007507:Therapeutic Irrigation / Q000379:methods; D014621:Vagina / Q000821:virology
D004279:DNA, Viral; D012367:RNA, Viral