Solid-phase tandem radical addition-cyclization reaction: triethylborane-induced reaction of oxime ethers anchored to polymer support.
Tandem radical addition-cyclization of oxime ethers anchored to polymer support was studied. The reaction of oxime ethers with stannyl radical proceeded effectively by the use of triethylborane as a radical initiator. The alkyl radical addition-cyclization reactions of oxime ether connected with alpha,beta-unsaturated carbonyl group proceeded under iodine atom-transfer reaction conditions to give the functionalized azacycles via two carbon-carbon bonds-forming process.
Miyabe
Hideto
H
Kobe Pharmaceutical University, Japan.
Tanaka
Hirotaka
H
Naito
Takeaki
T
D001880:Boranes / Q000737:chemistry / Q000378:metabolism*; D004987:Ethers / Q000737:chemistry / Q000378:metabolism*; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism*; D010091:Oximes / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*
D001880:Boranes; D004987:Ethers; D005609:Free Radicals; D010091:Oximes; D011108:Polymers; C079756:triethylborane