Anemia prevalence and associated risk factors in a single-center ambulatory HIV clinical cohort.
The prevalence of anemia in HIV-infected persons has not been well characterized in the HAART era. In a single-center, retrospective study, anemia prevalence and risk factors, including use of HAART, were assessed in an ambulatory clinical cohort of 758 HIV-infected patients for the calendar year 2000. The relationships between anemia (hemoglobin level less than 12.5 g/dL) and demographic variables, antiretroviral treatment regimens, and disease markers were analyzed. Mean baseline patient characteristics were hemoglobin level, 13.7 +/- 1.9 g/dL; CD4+ cell count, 405 +/- 293/microL; and HIV RNA level, 77,841 +/- 148,394 copies/mL. Overall anemia prevalence was 30.3%. Multivariate logistic regression analysis demonstrated that anemia was associated with a CD4+ cell count below 50/microL, female sex, black race, a viral load above 100,000 copies/mL, zidovudine use, and older age. Severe anemia was less prevalent in this study population than in historical comparators; however, mild to moderate anemia rates remain high.
Wills
Todd S
TS
University of South Florida, Tampa, Florida, USA.
Nadler
Jeffrey P
JP
Somboonwit
Charurut
C
Vincent
Albert
A
Leitz
Gerhard
G
Marino
Kimberly
K
Naik
Eknath
E
Powers
Stacy
S
Khan
Nadeem
N
Laartz
Brent
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000740:Anemia / Q000150:complications / Q000453:epidemiology*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005431:Florida / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D019562:Viral Load