title: Imaging correlates of molecular signatures in oligodendrogliomas.
abstract: Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T(1) images and mixed intensity signal on T(1) and T(2). Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.
authors.affiliation: Department of Clinical Neurological Sciences, University of Western Ontario and London Regional Cancer Centre, London, Ontario, Canada.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Megyesi
authors.forename: Edward
authors.initials: E
authors.lastname: Kachur
authors.forename: Donald H
authors.initials: DH
authors.lastname: Lee
authors.forename: Magdalena C
authors.initials: MC
authors.lastname: Zlatescu
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Betensky
authors.forename: Peter A
authors.initials: PA
authors.lastname: Forsyth
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Okada
authors.forename: Hikaru
authors.initials: H
authors.lastname: Sasaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mizoguchi
authors.forename: David N
authors.initials: DN
authors.lastname: Louis
authors.forename: J Gregory
authors.initials: JG
authors.lastname: Cairncross
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D015398:Signal Transduction