title: Effects of statin therapy on vascular dysfunction.
abstract: Dyslipidemia and vascular inflammation play critical roles in the onset of acute coronary syndromes including myocardial infarction. Recent advances in cardiovascular medicine demonstrate that lipid-lowering therapy by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) prevents acute coronary complications, probably by limiting inflammation in atheroma. Although a number of studies have suggested various effects of statins on vascular dysfunction independent of lipid lowering, the clinical benefits of such effects are not established as yet.
authors.affiliation: Center for Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA. maikawa@rics.bwh.harvard.edu
authors.forename: Masanori
authors.initials: M
authors.lastname: Aikawa
mesh_terms: D003324:Coronary Artery Disease / Q000188:drug therapy / Q000473:pathology; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors