Telomerase expression is differentially regulated in birds of differing life span.
Cellular senescence caused by telomere shortening has been suggested as one potential causal agent of aging. In some tissues, telomeres are maintained by telomerase; however, telomerase promotes tumor formation, suggesting a trade-off between aging and cancer. We predicted that telomerase activity should vary directly with life span. We determined telomerase activity in bone marrow in cross-sectional samples from two short-lived bird species and two long-lived bird species. The two short-lived species had high telomerase activity as hatchlings but showed a sharp downregulation in both the young and old adults, whereas the two long-lived species had relatively high telomerase activity in bone marrow that did not decrease with age. In zebra finches, the age-related change in telomerase activity varied in different tissues. Telomerase activity increased late in life in skeletal muscle, liver, and gonad, but not in blood or bone marrow.
Haussmann
Mark F
MF
Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA 50011, USA. hauss@iastate.edu
Winkler
David W
DW
Huntington
Charles E
CE
Nisbet
Ian C T
IC
Vleck
Carol M
CM
D000375:Aging; D000818:Animals; D001717:Birds; D001854:Bone Marrow Cells / Q000378:metabolism; D008136:Longevity; D020308:Songbirds; D013045:Species Specificity; D019098:Telomerase / Q000096:biosynthesis*; D016615:Telomere / Q000648:ultrastructure*; D013997:Time Factors; D014018:Tissue Distribution
D019098:Telomerase