title: Sex-specific effects of interventions that extend fly life span.
abstract: Genetic and environmental interventions that extend life span are a current focus in research on the biology of aging. Most of this work has focused on differences among genotypes and species. A recent study on fruit flies shows that life span extension because of dietary restriction can be highly sex-specific. Here we review the literature on sex-specific effects of 56 genetic and 41 environmental interventions that extend life span in Drosophila melanogaster. We found that only one-sixth of the experiments provided statistical tests of differences in response between males and females, suggesting that sex-specific effects have been largely ignored. When measured, the life span extension was female-biased in 8 of 16 cases, male-biased in 5 of 16 cases, and not significantly different in only 3 of 16 cases. We discuss possible explanations for the sex-specific differences and suggest various ways in which we might test these hypotheses. We argue that understanding sex differences in the response to life span-extending manipulations should lead to new insights about the basic mechanisms that underlie the biology of aging in both sexes.
authors.affiliation: Department of Genetics, University of Georgia, Athens, GA 30602-7223, USA. jmburger@uga.edujmburger@uga.edu
authors.forename: Joep M S
authors.initials: JM
authors.lastname: Burger
authors.forename: Daniel E L
authors.initials: DE
authors.lastname: Promislow
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005260:Female; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D008297:Male; D012737:Sex Factors