The ARTS connection: role of ARTS in apoptosis and cancer.
ARTS is an unusual septin that is localized to mitochondria in living cells and promotes apoptosis by antagonizing IAPs. ARTS functions as a tumor suppressor in Acute Lymphoblastic Leukemia (ALL) and is lost in more than 70% of leukemic patients. The loss of ARTS is specific as levels of H5, a closely related non-apoptotic septin protein derived from the same gene, were unaffected. Thus, ARTS, a new member in the mitochondrial pro-apoptotic arsenal, provides a link between mitochondria, apoptosis and cancer.
Larisch
Sarit
S
Pathology Department, Rambam Medical Center, Haifa, Israel. s.larisch@rambam.health.gov.il
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D058112:Septins
D003598:Cytoskeletal Proteins; D020558:GTP Phosphohydrolases; C492027:SEPTIN4 protein, human; D058112:Septins