Prognostic significance of the p185 protein in colorectal cancer.
The amplification and/or overexpression of the c-erbB-2/neu oncogene may play a role in tumor development and progression. The aim of this prospective study was to evaluate the prognostic value of p185 protein in colorectal cancer using immunohistochemical techniques. We analyzed 106 colorectal tumor tissue specimens from patients who had been operated on by the same surgeon and subjected to a median follow-up of 3 years. Thirty-three per cent of patients showed p185 overexpression related to an advanced stage of the disease. In patients with adenocarcinoma tumors of the colon without distant metastases, p185 detection was found to be of clinical prognostic relevance (p = 0.06).
Sanz-Casla
M T
MT
Service of Clinical Biochemistry. Tumor Biology Section. Hospital Clinico San Carlos. Madrid, Spain.
Vidaurreta
M
M
Maestro
M L
ML
López
J A
JA
Jiménez
F
F
Fernández
C
C
Maestro
C
C
Balibrea
J L
JL
Cerdán
F J
FJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D015996:Survival Rate
D018719:Erb-b2 Receptor Tyrosine Kinases