title: Endoscopic Doppler ultrasound after injection therapy for peptic ulcer hemorrhage.
abstract: OBJECTIVE
  A positive Doppler signal in endoscopic Doppler ultrasound at index endoscopy predicts a high risk for rebleeding from peptic ulcer. The aim of this study was to evaluate if a negative Doppler status immediately after injection therapy may exclude a rebleeding from peptic ulcer in a high-risk cohort.
  
  
  METHODS
  Twenty consecutive patients (pts) (age: 68 (33-91) yrs; 11 female) with peptic ulcer bleeding were enrolled. All patients with an actively bleeding ulcer and those with a non-actively bleeding, but Doppler-positive ulcer were treated by injection of adrenaline (1:10,000 dilution). Treatment was performed during index endoscopy until the Doppler status was negative. Patients were followed-up clinically and endoscopically (including Doppler ultrasound) for bleeding recurrence.
  
  
  RESULTS
  Patients were treated by injection of 12 (6 to 20) mL of adrenaline solution until Doppler scan was negative. During follow-up four pts (20%) had a clinically overt rebleeding episode. At control endoscopy three ulcers were actively bleeding and another two were Doppler positive without rebleeding (total: five of eighteen (27.7%) Doppler-positive ulcers). Two of the twenty pts required surgical therapy due to rebleeding (10%).
  
  
  CONCLUSIONS
  A negative endoscopic Doppler status immediately after injection therapy is not helpful to identify patients with no risk for rebleeding from peptic ulcer.
authors.affiliation: Department of Medicine C, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany. jakobsr@klilu.de
authors.forename: Ralf
authors.initials: R
authors.lastname: Jakobs
authors.forename: Thomas
authors.initials: T
authors.lastname: Zoepf
authors.forename: Dieter
authors.initials: D
authors.lastname: Schilling
authors.forename: Erhard G
authors.initials: EG
authors.lastname: Siegel
authors.forename: Juergen F
authors.initials: JF
authors.lastname: Riemann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D019160:Endosonography; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy; D016558:Hemostasis, Endoscopic; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012008:Recurrence; D019233:Retreatment; D012307:Risk Factors; D018608:Ultrasonography, Doppler
chemical_list: D004837:Epinephrine