title: Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells.
abstract: New structure-activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France.
authors.forename: Diana
authors.initials: D
authors.lastname: Ivanova
authors.forename: Aurélie
authors.initials: A
authors.lastname: Rossin
authors.forename: Hinrich
authors.initials: H
authors.lastname: Gronemeyer
authors.forename: Alain
authors.initials: A
authors.lastname: Valla
authors.forename: Dominique
authors.initials: D
authors.lastname: Cartier
authors.forename: Régis
authors.initials: R
authors.lastname: Le Guillou
authors.forename: Roger
authors.initials: R
authors.lastname: Labia
mesh_terms: D016923:Cell Death; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D006801:Humans; D006838:Hydrocarbons; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D012176:Retinoids / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D006838:Hydrocarbons; D012176:Retinoids; C030011:carbene; D008697:Methane