[Detection of eotaxin and its clinical diagnosis value in patients with bronchial asthma].
OBJECTIVE
To explore the role of eotaxin in the pathogenesis of bronchial asthma and the clinical value in the diagnosis of asthma.


METHODS
Serum eotaxin were measured by ELISA in 38 patients with asthma, 28 patients with non-asthma allergy, and 30 healthy controls.


RESULTS
The levels of serum eotaxin in the asthma group were higher than those in the non-asthma allergic and control group (P<0.01). Furthermore, eotaxin levels in patients with acute asthma were significantly higher than those in patients with stable asthma (P<0.001). It was also found that the eotaxin levels of the acute asthma group were positively correlated to the amounts of eosinophils in peripheral blood (r=0.4196, P<0.001), and inversely correlated to the forced expiratory volume in one second (FEV1) (r=-0.3746, P<0.001).


CONCLUSIONS
It suggests that eotaxin may play a crucial pathogenic role in the asthmatic process possibly by activating the allergic inflammatory cells and controlling the recruitment of eosinophils from blood to bronchial epithelium of the airway. The concentration of eotaxin is significantly associated with the attack of acute asthma and its severity. Eotaxin may be a potential therapeutic target in patients with asthma.
Liu
Zhong-juan
ZJ
Department of Laboratory Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. baobao-union@hotmail.com
Ren
Yan-li
YL
Lin
Jia-you
JY
Ni
An-ping
AP
D000328:Adult; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology; D002452:Cell Count; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000097:blood* / Q000502:physiology; D004802:Eosinophilia / Q000473:pathology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC