Delaying the mitochondrial decay of aging.
Mitochondrial dysfunction may be a principal underlying event in aging, including the degenerative diseases of aging such as brain degeneration. Mitochondria provide energy for basic metabolic processes, and their decay with age impairs cellular metabolism and leads to cellular decline. Progress over the last decade in delaying the mitochondrial decay of aging is reviewed.
Ames
Bruce N
BN
University of California, Berkeley, and Children's Hospital Oakland Research Institute, USA. bames@chori.org
D000108:Acetylcarnitine / Q000378:metabolism; D000375:Aging; D000818:Animals; D001710:Biotin / Q000172:deficiency; D001921:Brain / Q000473:pathology; D003300:Copper / Q000172:deficiency; D006418:Heme / Q000172:deficiency; D006801:Humans; D007700:Kinetics; D008928:Mitochondria / Q000473:pathology*; D010205:Pantothenic Acid / Q000172:deficiency / Q000378:metabolism; D011485:Protein Binding; D008063:Thioctic Acid / Q000378:metabolism; D025101:Vitamin B 6 / Q000378:metabolism; D014803:Vitamin B Complex / Q000378:metabolism; D015032:Zinc / Q000172:deficiency
D014803:Vitamin B Complex; D010205:Pantothenic Acid; D006418:Heme; D000108:Acetylcarnitine; D001710:Biotin; D008063:Thioctic Acid; D003300:Copper; D025101:Vitamin B 6; D015032:Zinc