Nitric oxide and tubulointerstitial nephritides.
As part of the exponential growth in our understanding of nitric oxide (NO) in health and disease over the past 2 decades, the kidney has become appreciated as a major site where NO may play a number of important roles. Although earlier work on the kidney focused more on effects of NO at the level of larger blood vessels and glomeruli, there has been a rapidly growing body of work showing critical roles for NO in tubulointerstitial disease. In this review we discuss some of the recent contributions to this important field.
Mattana
Joseph
J
Research Institute, North Shore-Long Island Jewish Health System, Manhasset, NY, USA. mattana@lij.edu
Adamidis
Ananea
A
Singhal
Pravin C
PC
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002908:Chronic Disease; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D019331:NG-Nitroarginine Methyl Ester / Q000627:therapeutic use*; D009395:Nephritis, Interstitial / Q000201:enzymology* / Q000503:physiopathology*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000187:drug effects / Q000378:metabolism*; D011379:Prognosis; D012720:Severity of Illness Index
D015415:Biomarkers; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester