Effect of Ginkgo biloba extract EGb 761 on the nonspecific and humoral immune responses in a hypothalamic-pituitary-adrenal axis activation model.
We evaluated the immune response of healthy control and stressed Wistar rats submitted to hypothalamic-pituitary-adrenal (HPA) axis activation. Rats were treated with Ginkgo biloba extract (EGb 761) orally (100 mg/kg per day for 7 days). EGb 761 stimulated the digestion index of peritoneal and alveolar macrophages (PM and AM) of stressed rats. Likewise, the cellular immune response measured using the delayed-type hypersensitivity response to sheep red blood cells (SRBC) and the humoral immune response (measured through an anti-SRBC response), were also restored in stressed rats. Thus, this G. biloba extract possesses immunostimulatory activity in addition to its broad spectrum of pharmacological effects.
Villaseñor-García
María Martha
MM
Laboratorio de Inmunofarmacología de Productos Naturales, División de Medicina Molecular CIBO-IMSS, Guadalajara, Jalisco, Mexico. mmvilla@cucs.udg.mx
Lozoya
Xavier
X
Osuna-Torres
Lidia
L
Viveros-Paredes
Juan Manuel
JM
Sandoval-Ramírez
Lucila
L
Puebla-Pérez
Ana María
AM
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004597:Electroshock; D004912:Erythrocytes / Q000276:immunology; D020441:Ginkgo biloba; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D010587:Phagocytosis / Q000276:immunology; D010913:Pituitary-Adrenal System / Q000502:physiology*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology / Q000503:physiopathology; D000096983:Ginkgo Extract
D000276:Adjuvants, Immunologic; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract