title: Prognostic value of micrometastases in esophageal and colorectal carcinoma (a clinical experience).
abstract: OBJECTIVE
  The term "micrometastases" has been confused in many aspects. While the influence of lymph node metastases in esophageal and colorectal cancer is well known, the presence and importance of micrometastases is under debate. We investigated micro lymph node invasion in two different kinds of digestive tumors with very high mortality, and identified its possible repercussion on patient survival.
  
  
  METHODS
  Lymph nodes of two groups of patients N0 on routine histopathology after radical resection (R0): 21 with esophageal carcinoma (Group I), and 21 with colorectal carcinoma (Group II), were studied by immunohistochemistry using monoclonal antibodies directed against cytokeratins of wide spectrum. The results were classified as positive or negative and compared with patient survival.
  
  
  RESULTS
  Five of twenty-one (5/21) patients in group I and eight of twenty-one (8/21) in group II were positive for micrometastases. Median survival time in the positive esophageal group was 9.5 months vs. 68 in the negative one (p=0.16). Median survival time in the positive subset colorectal group was 54.5 months vs. 76.8 in the negative subgroup (p=0.5). Our results did not show statistical differences in survival time between patients positive or negative for micrometastases; however it is evident, especially in the esophageal cancer group, that there is a negative tendency of positive micrometastases on survival time.
  
  
  CONCLUSIONS
  The presence of micrometastases in lymph nodes of patients N0 after conventional histopathology is frequent. Our preliminary results did not allow definitive conclusions but we may suppose its negative influence on patient survival.
authors.affiliation: Department of Surgery, Hospital Central, University of Oviedo, Oviedo, Spain.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Laso
authors.forename: Juan J
authors.initials: JJ
authors.lastname: González
authors.forename: Florentino
authors.initials: F
authors.lastname: Fresno
authors.forename: Enedina
authors.initials: E
authors.lastname: Azcano
authors.forename: Lourdes
authors.initials: L
authors.lastname: Sanz
authors.forename: Francisco
authors.initials: F
authors.lastname: Navarrete
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002277:Carcinoma / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D000911:Antibodies, Monoclonal; D007633:Keratins