Electrophoretic properties of acrylic latex suspensions (Kollicoat MAE 30 D) and ibuprofen.
We have compared the electrophoretic properties (measured on the electrical surface) of the commercial latex Kollicoat MAE 30 D and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen in preparation for attempts to develop a suitable vehicle for the NSAID to obtain a modified release formulation. Electrophoretic mobility of the latex and the active principle was measured in solutions containing different concentrations of inorganic electrolytes (NaCl, CaCl2 and AlCl3) at different pH values. This was considered an indispensable first step for further characterization of the substance's electrical properties. Suspensions of both the latex and the drug had negative mobility values throughout the range of pH values studied here. Of the electrolytes, neither NaCl nor CaCl2 led to positive mobility, and no isoelectric point could be determined. However, AlCl3 at a concentration of 10(-3) M led to the greatest reduction in mobility. We therefore found that trivalent cations were more effective than divalent cations, which in turn were more effective than monovalent cations, in reducing mobility.
Ruiz
M A
MA
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Granada 19871, Spain. adolfina@ugr.es
Gallardo
V
V
Ouazzani
N
N
López-Viota
J
J
López-Durán
J D G
JD
D000179:Acrylates / Q000737:chemistry*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D004586:Electrophoresis / Q000379:methods; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry*; D007840:Latex / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013499:Surface Properties; D013535:Suspensions
D000179:Acrylates; D017607:Aluminum Compounds; D002712:Chlorides; D004573:Electrolytes; D007840:Latex; D011109:Polymethacrylic Acids; D013535:Suspensions; C117135:kollicoat MAE 30 D; D000077410:Aluminum Chloride; D007052:Ibuprofen