The aging/precancerous gastric mucosa: a pilot nutraceutical trial.
The aim of this study was to test the effect of antioxidant supplementation on enzymatic abnormalities and free radical-modified DNA adducts associated with premalignant changes in the gastric mucosa of elderly patients with HP-negative atrophic gastritis (CAG). Sixty patients with atrophic gastritis and intestinal metaplasia underwent a nutritional interview and a gastroscopy with multiple biopsy samples in the antrum that were processed for histology and for assaying: alpha-tocopherol, MDA, xanthine oxidase (XO), ornithine decarboxylase (ODC), and 8-OHdG. Patients were randomly allocated into three matched groups and supplemented for 6 months with (1) vitamin E, 300 mg/day; (2) multivitamin, two tablets t.i.d.; and (3) Immun-Age 6 g/day nocte (ORI, Gifu, Japan), a certified fermented papaya preparation with basic science-validated antioxidant/immunomodulant properties. Ten dyspeptic patients served as controls. Histology and biochemistry were blindly repeated at 3 and 6 months. CAG patients showed a significantly (P <.05) increased level of mucosal MDA and XO concentration that were reverted to normal by each supplementation (P <.05). All supplements caused a significant decrease of ODC (P <.01), but Immun-Age yielded the most effective (P < 0.05) and was the only one significantly decreasing 8-OhdG (P < 0.05). These data suggest that antioxidant supplementation, and, namely, Immun-Age, might be potential chemopreventive agents in HP-eradicated CAG patients and especially in the elderly population.
Marotta
F
F
Hepato-Gastroenterology Unit, S. Giuseppe Hospital, Milan, Italy. fmarchimede@libero.it
Barreto
R
R
Tajiri
H
H
Bertuccelli
J
J
Safran
P
P
Yoshida
C
C
Fesce
E
E
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000375:Aging; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D018736:DNA Adducts; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D019587:Dietary Supplements; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis; D005757:Gastritis, Atrophic / Q000473:pathology*; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D009092:Mucous Membrane / Q000473:pathology; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress; D010865:Pilot Projects; D011230:Precancerous Conditions; D011897:Random Allocation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000473:pathology*; D015854:Up-Regulation; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D000975:Antioxidants; D018736:DNA Adducts; D016877:Oxidants; D014815:Vitamins; D014810:Vitamin E; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D014969:Xanthine Oxidase; D003849:Deoxyguanosine