title: Acquired fanconi syndrome induced by mixed Chinese herbs presenting as proximal muscle weakness.
abstract: We report a rare case with acquired Fanconi syndrome caused by mixed Chinese herbs, initially presenting as waddling gait and lower limb muscle atrophy. From a series of investigations, proximal renal tubule injury with functional defects and Chinese herb nephropathy were discovered. Hypophosphatemic osteomalacia and type II muscle fiber atrophy shown in muscle biopsy of left quadriceps may be associated with the sequelae of ingestion of mixed crude Chinese herbs. Aggressive and early alkali treatment with supplementation of phosphate and Vitamin D restored the patient's metabolic and musculoskeletal abnormalities.
authors.affiliation: Department of Internal Medicine, Armed Forces Taoyuan General Hospital, Taiwan, ROC.
authors.forename: Jenq-Shyong
authors.initials: JS
authors.lastname: Chan
authors.forename: An-Han
authors.initials: AH
authors.lastname: Yang
authors.forename: Ko-Pei
authors.initials: KP
authors.lastname: Kao
authors.forename: Der-Cherng
authors.initials: DC
authors.lastname: Tarng
mesh_terms: D000328:Adult; D001706:Biopsy; D005198:Fanconi Syndrome / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology; D008297:Male; D018908:Muscle Weakness / Q000139:chemically induced*; D010946:Plants, Medicinal / Q000009:adverse effects*