MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.
Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.
Morerio
Cristina
C
Dipartimento di Ematologia ed Oncologia Pediatrica, Istituto Giannina Gaslini, L.go G. Gaslini 5, 16148 Genova, Italy.
Rapella
Annamaria
A
Rosanda
Cristina
C
Lanino
Edoardo
E
Lo Nigro
Luca
L
Di Cataldo
Andrea
A
Maserati
Emanuela
E
Pasquali
Francesco
F
Panarello
Claudio
C
D019457:Chromosome Breakage; D007446:Chromosome Inversion; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D015321:Gene Rearrangement; D018740:Genetic Heterogeneity; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D014178:Translocation, Genetic
C470550:MLL-AF10 fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein