title: Localized linear IgA disease induced by ampicillin/sulbactam.
abstract: We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.
authors.affiliation: Department of Dermatology, University of Würzburg, Germany.
authors.forename: Iakov
authors.initials: I
authors.lastname: Shimanovich
authors.forename: Christian
authors.initials: C
authors.lastname: Rose
authors.forename: Cassian
authors.initials: C
authors.lastname: Sitaru
authors.forename: Eva-B
authors.initials: EB
authors.lastname: Bröcker
authors.forename: Detlef
authors.initials: D
authors.lastname: Zillikens
mesh_terms: D000368:Aged; D000667:Ampicillin / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000139:chemically induced*; D001706:Biopsy; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D000071821:Dystonin; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology; D013407:Sulbactam / Q000009:adverse effects*; D000097805:Collagen Type XVII
chemical_list: D000667:Ampicillin; D000900:Anti-Bacterial Agents; D001323:Autoantibodies; D001324:Autoantigens; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D007070:Immunoglobulin A; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D013407:Sulbactam; D000097805:Collagen Type XVII; C486268:DST protein, human; C035444:sultamicillin