Evaluation of a high-dose dexamethasone-eluting stent.
This study evaluated the safety and efficacy of a dexamethasone-eluting stent with a special high dexamethasone-loading dose for treatment of de novo coronary lesions in 30 patients. Eight patients had in-stent restenosis (restenosis rate 31%) at 6-month follow-up, and the in-stent late lumen loss was 0.96 +/- 0.63 mm due to an average intimal hyperplasia area obstruction of 32 +/- 21%, indicating that high-dose dexamethasone-loaded stents do not significantly reduce neointimal proliferation.
Hoffmann
Rainer
R
Medical Clinic I, University Hospital Aachen, Germany. RHoffman@UKAACHEN.de
Langenberg
Roswitha
R
Radke
Peter
P
Franke
Andreas
A
Blindt
Rüdiger
R
Ortlepp
Jan
J
Popma
Jeff J
JJ
Weber
Christian
C
Hanrath
Peter
P
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000517:prevention & control*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011474:Prosthesis Design; D015607:Stents; D018084:Ultrasonography, Interventional
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone