title: Value of fetal autopsy after medical termination of pregnancy.
abstract: We carried out a retrospective study of 352 medical terminations of pregnancy (MTP) carried out in a large French administrative region over two consecutive years. We analysed the indications for MTP and then compared the prenatal ultrasound diagnosis with fetal autopsy findings in order to demonstrate the value of pathological examination of the fetus in prenatal diagnosis and genetic counselling as well as the need to check by autopsy the quality of ultrasound screening. Preliminary analysis of the indication for these MTP showed that in 69.9% ultrasound screening had been carried out, revealing mainly brain abnormalities (22.2%) and heart defects generally associated with chromosomal abnormalities (32.1%). Prenatal findings were in agreement with autopsy results, showing no false-positive prenatal diagnoses. However, in 7.9% of cases in which brain abnormalities were detected, confirmation was not possible at autopsy because of tissue autolysis, showing the need for optimal conditions of expulsion. In 35.8% of cases, confirmation of the diagnosis by autopsy was not useful for management but still added to medical knowledge and demonstrated to the mother the reality of the defects. In 50.9%, the autopsy findings were decisive for genetic counselling.
authors.affiliation: Service de Médecine Légale, CHU Timone, 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France. mpiercecchi@ap-hm.fr
authors.forename: M D
authors.initials: MD
authors.lastname: Piercecchi-Marti
authors.forename: A
authors.initials: A
authors.lastname: Liprandi
authors.forename: S
authors.initials: S
authors.lastname: Sigaudy
authors.forename: C
authors.initials: C
authors.lastname: Fredouille
authors.forename: P
authors.initials: P
authors.lastname: Adalian
authors.forename: D
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: J F
authors.initials: JF
authors.lastname: Pellissier
mesh_terms: D037881:Aborted Fetus / Q000473:pathology*; D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D001344:Autopsy; D002869:Chromosome Aberrations; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging / Q000235:genetics; D005260:Female; D005602:France; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal