Protection of adrenocortical activity by dietary casein in ether anaesthetized rats.
Adrenal delta5-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) activity and serum corticosterone level were significantly higher in rats fed with 5% casein or 4% albumin diets after 1 hr of ether anaesthetic stress as compared to the controls, 5% casein and 20% casein (equivalent to 4% albumin) respectively. Ether anaesthesia to 20% casein fed rats caused no change in adrenal delta5-3beta-HSD activity and serum corticosterone level when compared with controls fed 20% casein diet. The results suggest that high milk protein diet may prevent acute stress effects by protecting adrenocortical activity. The present investigation opens up a new area of management of stress.
Biswas
N M
NM
Department of Physiology, University College of Science & Technology, 92, Acharya Prafulla Chandra Road, Kolkata 700 009, India. drnmbiswas@rediffmail.com
Chattopadhyay
A
A
Sarkar
M
M
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000302:Adrenal Cortex / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D000418:Albumins / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D002364:Caseins / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D004032:Diet; D004986:Ether / Q000737:chemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000418:Albumins; D002364:Caseins; D002614:Chelating Agents; D004986:Ether; D015096:3-Hydroxysteroid Dehydrogenases; C031954:delta(5)-3 beta-hydroxysteroid dehydrogenase; D003345:Corticosterone