Light- and singlet oxygen-mediated antifungal activity of phenylphenalenone phytoalexins.
The light-induced singlet oxygen production and antifungal activity of phenylphenalenone phytoalexins isolated from infected banana plants (Musa acuminata) are reported. Upon absorption of light energy all studied phenylphenalenones sensitise the production of singlet oxygen in polar and non-polar media. Antifungal activity of these compounds towards Fusarium oxysporum is enhanced in the presence of light. These results, together with the correlation of IC50 values under illumination with the quantum yield of singlet oxygen production and the enhancing effect of D2O on the antifungal activity, suggest the intermediacy of singlet oxygen produced by electronic excitation of the phenylphenalenone phytoalexins.
Lazzaro
Alejandra
A
Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017-Barcelona, Spain.
Corominas
Montserrat
M
Martí
Cristina
C
Flors
Cristina
C
Izquierdo
Laura R
LR
Grillo
Teresa A
TA
Luis
Javier G
JG
Nonell
Santi
S
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000528:radiation effects; D005638:Fruit / Q000737:chemistry; D005670:Fusarium / Q000528:radiation effects; D008027:Light; D015394:Molecular Structure; D010777:Photochemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000528:radiation effects; D012717:Sesquiterpenes; D026082:Singlet Oxygen / Q000737:chemistry; D013729:Terpenes; D000094162:Phytoalexins
D000935:Antifungal Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; D013729:Terpenes; D026082:Singlet Oxygen; D000094162:Phytoalexins