Analysis of clinical effect of high-intensity focused ultrasound on liver cancer.
OBJECTIVE
To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in the treatment of patients with liver cancer.


METHODS
HIFU treatment was performed in 100 patients with liver cancer under general anesthesia and by a targeted ultrasound. Evaluation of efficacy was made on the basis of clinical symptoms, liver function tests, AFP, MRI or CT before and after the treatment.


RESULTS
After HIFU treatment, clinical symptoms were relieved in 86.6%(71/82) of patients. The ascites disappeared in 6 patients. ALT (95+/-44) U/L and AST (114+/-58) U/L before HIFU treatment were reduced to normal in 83.3%(30/36) and 72.9%(35/48) patients, respectively, after the treatment. AFP was lowered by more than 50% in 65.3%(32/49) patients. After HIFU treatment, MRI or CT findings indicated coagulation necrosis and blood supply reduction or disappearance of tumor in the target region.


CONCLUSIONS
HIFU can efficiently treat the patients with liver cancer. It will offer a significant noninvasive therapy for local treatment of liver tumor.
Li
Chuan-Xing
CX
Department of HIFU, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China. lichx@163.net
Xu
Guo-Liang
GL
Jiang
Zhen-You
ZY
Li
Jian-Jun
JJ
Luo
Guang-Yu
GY
Shan
Hong-Bo
HB
Zhang
Rong
R
Li
Yin
Y
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014464:Ultrasonic Therapy