The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons.
The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.
Strand
Stephanie S
SS
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA.
Vanheyningen
Tambryn K
TK
Leib
David A
DA
D000818:Animals; D002522:Chlorocebus aethiops; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics; D018259:Herpesvirus 1, Human / Q000502:physiology*; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D012260:Ribonucleases; D014709:Vero Cells; D014764:Viral Proteins / Q000502:physiology*
D014764:Viral Proteins; C070722:virion host shutoff protein, Simplexvirus; D012313:RNA; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D012260:Ribonucleases