Sp1 control of gene expression in myeloid cells.
Gene transcription plays a critical role in the differentiation of myeloid cells. However, there is no single, master regulator of all myeloid genes. Rather, myeloid gene transcription is regulated by the combinatorial effects of a limited number of key transcription factors. Sp1 is a powerful activator of gene transcription in many cell types. Although it is wildly expressed, Sp1 binds and activates the promoters of a large number of important myeloid genes. This presents the paradox of how a widely expressed transcription factor can regulate lineage-specific gene transcription. This review discusses the structure, function, and expression patterns of Sp1 and its related Sp family members. Illustrative examples of the tissue-specific regulation of myeloid target genes are presented. The roles of post-translational modifications of Sp1, alterations in target gene chromatin structure, and important cooperating transcription factors are discussed. Thus, Sp1 serves as a model of how a widely expressed transcription factor regulates the expression of tissue-specific genes.
Resendes
Karen K
KK
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.
Rosmarin
Alan G
AG
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D022423:Myeloid Cells / Q000166:cytology / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D016329:Sp1 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D051705:Sp3 Transcription Factor; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D004268:DNA-Binding Proteins; D016329:Sp1 Transcription Factor; D014157:Transcription Factors; D051705:Sp3 Transcription Factor