title: Fast acquisition-weighted three-dimensional proton MR spectroscopic imaging of the human prostate.
abstract: The clinical application of 3D proton spectroscopic imaging (3D SI) of the human prostate requires a robust suppression of periprostatic lipid signal contamination, minimal intervoxel signal contamination, and the shortest possible measurement time. In this work, a weighted elliptical sampling of k-space, combined with k-space filtering and pulse repetition time (TR) reduction minimized lipid signals, intervoxel contamination, and measurement time. At 1.5 T, the MR-visible prostate metabolites citrate, creatine, and choline can now be mapped over the entire human prostate with uncontaminated spherical voxels, with a volume down to 0.37 cm3, in measurement times of 7-15 min.
authors.affiliation: Department of Radiology, University Medical Center Nijmegen, Nijmegen, The Netherlands. T.Scheenen@rad.umcn.nl
authors.forename: Tom W J
authors.initials: TW
authors.lastname: Scheenen
authors.forename: Dennis W J
authors.initials: DW
authors.lastname: Klomp
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Röll
authors.forename: Jurgen J
authors.initials: JJ
authors.lastname: Fütterer
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
authors.forename: Arend
authors.initials: A
authors.lastname: Heerschap
mesh_terms: D000328:Adult; D006801:Humans; D021621:Imaging, Three-Dimensional; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*