[Stem-cell engraftment as delayed therapy to repair organophosphate-induced brain damage].
Amongst organophosphate compounds, both pesticides and warfare neurotoxics are probably the most representative. These compounds are irreversible acetylcholinesterase inhibitors. Usual clinical signs observed after acute poisoning are mainly respiratory distress, convulsions and seizures. Following acute poisoning, an emergency treatment must be provided as soon as possible (maximum delay of 1 hour post-poisoning), to prevent irreversible brain damage and patient death. At the present time, there is no efficient delayed treatment which could be provided if this 1 hour latency is overpassed. However, neurogenesis by stem cell engraftment, eventually complemented by gene therapy strategy, could be a potential therapeutic approach to repair organophosphate-induced brain damage. Main stem cell engraftement strategies successfully used for brain damage of various origins are reviewed in this Article.
Collombet
J-M
JM
Centre de Recherches du Service de Santé des Armées (CRSSA), département de toxicologie, Unité de Neuropharmacologie, 24, avenue des Maquis du Grésivaudan, B.P. 87, F 38702 La Tronche Cedex. jmcollombet@crssa.net
Baubichon
D
D
Four
E
E
Masqueliez
C
C
Dorandeu
Fr
F
Lallement
G
G
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy*; D002619:Chemical Warfare Agents / Q000506:poisoning; D006801:Humans; D009474:Neurons / Q000637:transplantation; D020258:Neurotoxicity Syndromes / Q000473:pathology / Q000628:therapy*; D062025:Organophosphate Poisoning; D033581:Stem Cell Transplantation
D002619:Chemical Warfare Agents