Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa.
Various studies have evaluated the possible role of the -1438G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P = 0.003 and P = 0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P = 0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies.
Ricca
Valdo
V
Department of Neurological and Psychiatric Sciences, Psychiatry Unit, University of Florence, Viale Morgagni, 85, 50134, Italy. valdo.ricca@unifi.it
Nacmias
Benedetta
B
Boldrini
Maura
M
Cellini
Elena
E
di Bernardo
Milena
M
Ravaldi
Claudia
C
Tedde
Andrea
A
Bagnoli
Silvia
S
Placidi
Gian Franco
GF
Rotella
Carlo Maria
CM
Sorbi
Sandro
S
D000328:Adult; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology*; D002032:Bulimia / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A