Immune responses in Anopheles gambiae.
Transmission of human malaria requires a successful development of Plasmodium parasites in anopheline mosquitoes. Insects have developed efficient immune responses to oppose microbial and eukaryotic invaders. The completion of the sequencing of the Anopheles genome provides a wealth of information on putative immune genes that are homologous to components of the Drosophila and mammalian immune systems. In this review, we will summarize our present knowledge of immune responses in the mosquito Anopheles gambiae and attempt a comparative analysis of insect immune systems.
Levashina
Elena A
EA
UPR 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F-67084 Strasbourg Cedex, France. e.levashina@ibmc.u-strasbg.fr
D000818:Animals; D000852:Anopheles / Q000276:immunology*; D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D009033:Culicidae / Q000276:immunology; D004175:Diptera / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D008288:Malaria / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology*
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides