title: Prevention of perinatal hepatitis B transmission in a health authority area: an audit.
abstract: The aim of this audit was to provide baseline measurement of antenatal hepatitis B virus (HBV) screening uptake, coverage of HBV vaccination in infants born to high- and low-risk HBsAg carrier mothers, completion of post-vaccination serological testing, outcome for vaccinated infants, and an assessment of the factors that influenced the effectiveness of the whole programme. Methods included identifying HBV positive pregnancies by laboratory results, and follow up of at-risk infants by a GP survey. Uptake of antenatal HBV screening was 99.9%. Thirty-one HBV positive pregnancies were identified, and twenty-nine infants were followed up. The overall HBV vaccination completion rate was 93%. Fifty per cent of eligible infants were tested for hepatitis carriage, the majority of whom were high-risk infants. None had acquired HBV infection and all had gained adequate immunity. We conclude that, although the local screening programme has been implemented effectively, there is inconsistency in the follow up of infants at high and low risk of acquiring HBV.
authors.affiliation: Essex Health Protection Team, Witham, Essex. sam.bracebridge@hpa.org.uk
authors.forename: S
authors.initials: S
authors.lastname: Bracebridge
authors.forename: D
authors.initials: D
authors.lastname: Irwin
authors.forename: S
authors.initials: S
authors.lastname: Millership
mesh_terms: D004739:England; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000175:diagnosis / Q000517:prevention & control* / Q000635:transmission*; D006511:Hepatitis B Antigens / Q000032:analysis; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data*; D008485:Medical Audit; D015997:Neonatal Screening / Q000706:statistics & numerical data; D018743:Perinatal Care / Q000592:standards*; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis; D013222:State Medicine / Q000592:standards; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D006511:Hepatitis B Antigens; D017325:Hepatitis B Vaccines