Sef: a MEK/ERK catcher on the Golgi.
Subcellular compartmentalization is an emerging paradigm in signaling pathways including the Ras/MAPK pathway. In a recent issue of Developmental Cell, Torii et al. (2004) characterize a new MAPK scaffold, Sef, that resides on the Golgi apparatus, binds active MEK/ERK complexes, and permits signaling to cytosolic substrates but not nuclear targets.
Philips
Mark R
MR
NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA.
D000818:Animals; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D018123:Receptors, Interleukin / Q000502:physiology*
C477526:IL17RD protein, human; D018123:Receptors, Interleukin; D020928:Mitogen-Activated Protein Kinases