Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia.
The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities and to evaluate the relationship between these parameters and the severity of pre-eclampsia. Twenty-five pre-eclamptic, 15 healthy pregnant and 15 non-pregnant women were enrolled in this study. Increased mean plasma XO activity was found to be higher in both pre-eclampsia groups than in the healthy pregnant group. Plasma UA levels were the highest in the severe pre-eclampsia group among the study groups. SOD and GSH-Px activities were significantly lower in both pre-eclampsia groups than in the healthy pregnant group (p < 0.005 and p < 0.001, respectively). Increased XO and decreased SOD and GSH-Px activities may contribute to the pathophysiological mechanisms of pre-eclampsia and increased UA may serve a protective role responding to superoxide radicals arising from increased XO activity or other sources in pre-eclampsia.
Yildirim
Abdulkadir
A
Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey.
Altinkaynak
Konca
K
Aksoy
Hulya
H
Sahin
Y Nuri
YN
Akcay
Fatih
F
D000328:Adult; D001794:Blood Pressure; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D017382:Reactive Oxygen Species; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood*; D014527:Uric Acid / Q000097:blood*; D014969:Xanthine Oxidase / Q000097:blood*; D055815:Young Adult
D017382:Reactive Oxygen Species; D014527:Uric Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase