title: Is praziquantel therapy safe during pregnancy?
abstract: Schistosomiasis control programmes are generally based on mass distribution of praziquantel (PZQ). This approach has been further strengthened by studies that demonstrated reduction in schistosomiasis-related morbidity following regular use of PZQ. Many women were excluded from this therapy when pregnant. Since a high degree of parity is achieved in many schistosomiasis-endemic regions, excluded women often miss treatment and consequently the beneficial effect of this therapy. This study investigated the effect of PZQ therapy on pregnancy in the Gezira region of Sudan. As part of the Blue Nile Health Project, more than 320,000 individuals received annual treatment with PZQ from 1980 to 1990. The present study reviewed the treatment records of all women between 1990 and 1995 in four villages. Eighty-eight of 637 women interviewed had received PZQ during their pregnancy. The outcome and the effect of PZQ therapy on their offspring were compared with a group of 549 women who had not received the drug during pregnancy. There were no significant differences between the two groups in the rate of abortion or preterm deliveries. No congenital abnormalities were noted by clinical examination in any of the babies born to either group. This retrospective study suggested that PZQ therapy is safe during pregnancy.
authors.affiliation: New Halfa Hospital, P.O. Box 61, New Halfa, Sudan. ishagadam@hotmail.com
authors.forename: Ishag
authors.initials: I
authors.lastname: Adam
authors.forename: El Taib
authors.initials: el T
authors.lastname: Elwasila
authors.forename: Mamoun
authors.initials: M
authors.lastname: Homeida
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D000871:Anthelmintics / Q000009:adverse effects*; D002675:Child, Preschool; D019353:Endemic Diseases / Q000517:prevention & control; D005260:Female; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D011223:Praziquantel / Q000009:adverse effects*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012423:Rural Health; D012552:Schistosomiasis / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D013397:Sudan / Q000453:epidemiology
chemical_list: D000871:Anthelmintics; D011223:Praziquantel