Testican-1: a differentially expressed proteoglycan with protease inhibiting activities.
Testican-1 is a highly conserved, multidomain proteoglycan that is most prominently expressed in the thalamus of the brain, and is upregulated in activated astroglial cells of the cerebrum. Several functions of this gene product have now been demonstrated in vitro including membrane-type matrix metalloproteinase inhibition, cathepsin L inhibition, and low-affinity calcium binding. The purified gene product has been shown to inhibit cell attachment and neurite extensions in culture. Functions of testican in vivo have yet to be demonstrated in knockout mice or other models. Testican has been shown to carry substantial amounts of chondroitin sulfate as well as other oligosaccharides, but the biological significance of these embellishments is not yet known.
Edgell
Cora-Jean S
CJ
Pathology Department, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7525, USA.
BaSalamah
Mohammad A
MA
Marr
Henry S
HS
D000595:Amino Acid Sequence; D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D056668:Cathepsin L; D002403:Cathepsins / Q000037:antagonists & inhibitors; D002448:Cell Adhesion; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism; D003546:Cysteine Endopeptidases; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors; D009844:Oligosaccharides / Q000378:metabolism; D011480:Protease Inhibitors / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D011509:Proteoglycans / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D014018:Tissue Distribution
D006025:Glycosaminoglycans; D009844:Oligosaccharides; D011480:Protease Inhibitors; D011509:Proteoglycans; D012333:RNA, Messenger; C504369:SPOCK1 protein, human; D002403:Cathepsins; D003546:Cysteine Endopeptidases; C534281:CTSL protein, human; D056668:Cathepsin L; C534278:Ctsl protein, mouse; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases