Online prediction of self-paced hand-movements from subthalamic activity using neural networks in Parkinson's disease.
The significance of local field potential (LFP) activity in the subthalamic nucleus (STN) of patients with Parkinson's disease is unclear. Here we show that it is possible to predict self-paced hand-movements from the oscillatory nature of the STN LFP on a trial-by-trial basis. To this end we used a neural networks' classification algorithm on features representing different measures of spectral activity. Our experiments were simulated to process online LFP signal recordings collected beforehand from macroelectrodes implanted in STN. With spectral features extracted via wavelet transformation, we were able to predict a voluntary hand-movement's onset with 95% sensitivity and 77% specificity. Most predictions were made over a second in advance of the movement. We conclude that oscillatory LFP activity in STN is directly or indirectly related to processes involved in motor preparation. The ability to predict movement in real-time may open up several experimental and therapeutic possibilities.
Loukas
Constantinos
C
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK. cloukas@ion.ucl.ac.uk
Brown
Peter
P
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D000465:Algorithms; D004599:Electric Stimulation Therapy / Q000379:methods; D019277:Entropy; D005260:Female; D006225:Hand / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D016571:Neural Networks, Computer; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D011237:Predictive Value of Tests; D012372:ROC Curve; D020531:Subthalamic Nucleus / Q000503:physiopathology* / Q000528:radiation effects