title: Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
abstract: Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.
authors.affiliation: Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA. tschoemh@ucmail.uc.edu
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mesh_terms: D000818:Animals; D017849:Animals, Inbred Strains; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D001067:Appetite Depressants / Q000494:pharmacology* / Q000627:therapeutic use; D001069:Appetite Regulation / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004777:Environment; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D015201:Meta-Analysis as Topic; D051379:Mice; D009765:Obesity / Q000188:drug therapy; D010446:Peptide Fragments; D019894:Peptide YY / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D015203:Reproducibility of Results; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology
chemical_list: D001067:Appetite Depressants; D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36)