title: Rapid neural differentiation of human cord blood-derived mesenchymal stem cells.
abstract: Human umbilical cord blood (UCB) contains hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), both of which are regarded as valuable sources for cell transplantation and cell therapy. Adherent cells expressing MSCs-related antigens such as SH2, CD13, CD29, and ASMA, have been isolated from a mononuclear cell fraction of human UCB. Under proneurogenic conditions, these UCB-derived adherent cells rapidly assumed the morphology of multipolar neurons. Both immunofluorescence and RT-PCR analyses indicated that the expression of a number of neural markers including Tuj1, TrkA, GFAP and CNPases, was markedly elevated during this acute differentiation. The neurogenic potential of UCB-derived may facilitate stem cell therapeutic approaches to neurodegenerative diseases.
authors.affiliation: Research Institute of Biotechnology, Histostem Co., 518-4 Taijul Bldg, Doonchun-dong, Kangdong-gu, Seoul 134-060, Korea.
authors.forename: Ju Ah
authors.initials: JA
authors.lastname: Jeong
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Gang
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Hong
authors.forename: Soo Han
authors.initials: SH
authors.lastname: Hwang
authors.forename: Seong Whan
authors.initials: SW
authors.lastname: Kim
authors.forename: Il Ho
authors.initials: IH
authors.lastname: Yang
authors.forename: Chiyoung
authors.initials: C
authors.lastname: Ahn
authors.forename: Hoon
authors.initials: H
authors.lastname: Han
authors.forename: Hoeon
authors.initials: H
authors.lastname: Kim
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D002478:Cells, Cultured; D005312:Fetal Blood / Q000166:cytology* / Q000502:physiology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology