title: Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients.
abstract: OBJECTIVE
  To investigate a possible implication of inflammatory processes in the development of dementia in cerebrovascular disease.
  
  
  METHODS
  We examined the levels of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) (n = 26), ischemic cerebrovascular disease without dementia (CVD) (n = 11), vascular dementia (VD) (n = 11), and other neurological disorders (n = 21) using sensitive enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The CSF concentrations of IL-6 were significantly elevated in patients with VD compared with those of patients with AD or CVD.
  
  
  CONCLUSIONS
  The CSF IL-6 levels are increased in patients with VD, suggesting that inflammatory mechanisms may be involved in the development of cognitive decline in some patients with cerebrovascular disease. CSF IL-6 may be a biological marker for dementia in cerebrovascular disease.
authors.affiliation: Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan. kewada@grape.med.tottori-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Wada-Isoe
authors.forename: Y
authors.initials: Y
authors.lastname: Wakutani
authors.forename: K
authors.initials: K
authors.lastname: Urakami
authors.forename: K
authors.initials: K
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid; D002545:Brain Ischemia / Q000134:cerebrospinal fluid; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid* / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D015850:Interleukin-6; D016875:tau Proteins