title: In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis.
abstract: The antimicrobial peptide protegrin-1 (PG-1) inhibited the growth in vitro of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis; a lower activity was shown by human beta-defensin-1 (HBD-1) against both strains. The combination of PG-1 or HBD-1 with isoniazid significantly reduced M. tuberculosis growth in comparison with the peptides or isoniazid alone.
authors.affiliation: Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Lanfranco
authors.initials: L
authors.lastname: Fattorini
authors.forename: Renato
authors.initials: R
authors.lastname: Gennaro
authors.forename: Margherita
authors.initials: M
authors.lastname: Zanetti
authors.forename: Dejiang
authors.initials: D
authors.lastname: Tan
authors.forename: Lara
authors.initials: L
authors.lastname: Brunori
authors.forename: Federico
authors.initials: F
authors.lastname: Giannoni
authors.forename: Manuela
authors.initials: M
authors.lastname: Pardini
authors.forename: Graziella
authors.initials: G
authors.lastname: Orefici
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D004357:Drug Synergism; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D023083:beta-Defensins / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; C406407:DEFB1 protein, human; D011506:Proteins; D023083:beta-Defensins; C094880:protegrin-1; D007538:Isoniazid