Anti-ulcerogenic lignans from Taxus baccata L.
Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-iso-lariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-ulcerogenic potency of these compounds was investigated on ethanol-induced ulcerogenesis model in rats at two different doses, 50 and 100 mg/kg. All compounds were shown to possess significant anti-ulcerogenic activity at both doses. However, the effect of taxiresinol was the most prominent.
Gurbuz
Ilhan
I
Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Hipodrom 6330, Ankara, Turkey.
Erdemoglu
Nurgun
N
Yesilada
Erdem
E
Sener
Bilge
B
D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002850:Chromatography, Gel; D004195:Disease Models, Animal; D000431:Ethanol; D005260:Female; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D020946:Taxus / Q000737:chemistry*; D014421:Turkey; D014934:Wood
D000897:Anti-Ulcer Agents; D017705:Lignans; D010936:Plant Extracts; D000431:Ethanol