title: Bronchiolitis obliterans organizing pneumonia following chlorambucil treatment for chronic lymphocytic leukemia.
abstract: A 70-yr-old man developed cough, chest pain, hemoptysis and a pulmonary infiltrate shortly after initiation of treatment with chlorambucil for chronic lymphocytic leukemia. Chlorambucil was discontinued and an open lung procedure was performed with complete excision of the pulmonary lesion. The biopsy specimens showed histological alteration consistent with the diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP). There was no evidence of other known causes usually associated with BOOP. The patient recovered completely after surgery. This report suggests that BOOP must be considered in the differential diagnosis of respiratory symptoms and pulmonary infiltrates in patients treated with chlorambucil.
authors.affiliation: Department of Internal Medicine, Medical School of Ioannina, Ioannina, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Kalambokis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Stefanou
authors.forename: Evdokia
authors.initials: E
authors.lastname: Arkoumani
authors.forename: Epameinondas
authors.initials: E
authors.lastname: Tsianos
mesh_terms: D000368:Aged; D001706:Biopsy; D002699:Chlorambucil / Q000009:adverse effects*; D018549:Cryptogenic Organizing Pneumonia / Q000139:chemically induced* / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D002699:Chlorambucil