[Neuropsychology and epilepsy].
OBJECTIVE
The epileptic child has three times more risk of presenting cognitive disorders than other children with no neurological pathology, in accordance with three essential facts: 1. The effect exerted by the actual epilepsy. 2. Any associated previously-existing neuropsychosocial deficits. 3. The side effects of the antiepileptic drug (AED). A certain amount of deterioration is universally accepted, without defining the factors involved in its production, but which are multifactorial according to computer studies. From this point of view, we analyse the relation between neuropsychology and epilepsy in Paediatrics.


METHODS
The relation between epilepsy and behaviour must be seen as an exception and not the rule, unless there are coexisting personality disorders and/or mental deficiency. The cognitive effects of AED depend on the drug, the doses used and on the polypharmacy, and these effects may be both adverse and beneficial. The differences from one drug to another are questionable due to the methodology used in the different studies and it should be remembered that with suitable doses the side effects are generally moderate, and AED monitoring is useful in this case. We recommend the use of MEDDRA assessment to obtain a more reliable definition of side effects, which in turn will allow them to be better evaluated. Scaling time in the introduction of the drug is important, especially with some of the new AED. The mechanisms governing the production of the side effects vary, but both the classical and the new ones, which are well used owing to the greater knowledge we have of their mechanism of action, improve cognitive functioning by controlling the seizures. In infancy, idiopathic cognitive reactions are produced. In childhood, the main disorders are a diminished reaction and information processing time with alterations affecting memory, attention and language.


CONCLUSIONS
Epilepsy is associated to a number of different, generally mild, cognitive problems. The age of onset of epilepsy, type of syndrome, its aetiology, the response to treatment and polypharmacy are multifactorial elements conditioning side effects. There is a need for batteries of tests capable of forecasting the future and controlling the progression of cognition during therapy. It can be concluded that the side effects of AED affecting cognition and behaviour are generally mild, but the cognitive side effect of an AED can be important for a particular child.
Campos-Castelló
J
J
Servicio de Neuropediatría, Hospital Clínico San Carlos, Madrid, Spain. jcampos.hcsc@salud.madrid.org
Campos-Soler
S
S
D000927:Anticonvulsants / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001519:Behavior / Q000187:drug effects / Q000502:physiology*; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000503:physiopathology; D015897:Comorbidity; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology; D009483:Neuropsychological Tests; D009484:Neuropsychology
D000927:Anticonvulsants