Efficient acyclic stereocontrol using the tethered aminohydroxylation reaction.
[reaction: see text] The tethered aminohydroxylation (TA) of acyclic allylic carbamates has been achieved in a stereospecific and stereoselective manner. Unusually high levels of stereocontrol were observed in the oxidation of 1,1-disubstituted substrates.
Donohoe
Timothy J
TJ
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK. tiothy.donohoe@chem.ox.ac.uk
Johnson
Peter D
PD
Pye
Richard J
RJ
Keenan
Martine
M