Mechanism of superoxide-mediated damage relevance to mitochondrial aging.
The damaging effects of superoxide in mitochondria leading to pathological disorders and aging are well documented and usually ascribed to superoxide's role as a precursor of reactive free radical species. However, the latest findings point out the importance of the nucleophilic properties of superoxide and its ability to regulate heterolytic enzymatic processes. Hypothetical mechanisms of superoxide mediation of phosphorylation and dephosphorylation reactions with participation of protein kinases and the apoptotic protein BAD are considered.
Afanas'Ev
I B
IB
Vitamin Research Institute, Moscow, Russia. iafan@aha.ru
D000375:Aging; D000818:Animals; D017209:Apoptosis; D002352:Carrier Proteins / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D006868:Hydrolysis; D051379:Mice; D008928:Mitochondria / Q000473:pathology*; D008954:Models, Biological; D008956:Models, Chemical; D010766:Phosphorylation; D051381:Rats; D011918:Rats, Inbred SHR; D017382:Reactive Oxygen Species; D015398:Signal Transduction; D013481:Superoxides; D051025:bcl-Associated Death Protein
C494819:BAD protein, human; C494820:Bad protein, mouse; C494821:Bad protein, rat; D002352:Carrier Proteins; D005609:Free Radicals; D017382:Reactive Oxygen Species; D051025:bcl-Associated Death Protein; D013481:Superoxides