Replication factors license exonuclease I in mismatch repair.
A key question in the eukaryotic mismatch repair field is how strand excision is coordinated with mismatch recognition. In a recent issue of Molecular Cell, Dzantiev et al. present evidence that the replication factors PCNA and RFC modulate the directionality of EXOI-mediated excision.
Surtees
Jennifer A
JA
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Alani
Eric
E
D000818:Animals; D020137:Base Pair Mismatch / Q000235:genetics*; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D045643:DNA Repair Enzymes; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism*; D006801:Humans; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051818:Replication Protein C; D014157:Transcription Factors / Q000378:metabolism
D002843:Chromatin; D004268:DNA-Binding Proteins; D018809:Proliferating Cell Nuclear Antigen; C081632:RFC1 protein, human; D014157:Transcription Factors; D004247:DNA; C114331:EXO1 protein, human; D005090:Exodeoxyribonucleases; C028450:exodeoxyribonuclease I; D051818:Replication Protein C; D045643:DNA Repair Enzymes