The role of insulin and insulin-like growth factor-I in mammalian ageing.
Research with invertebrates over the past 10 years has suggested that alterations in insulin and/or insulin-like growth factor I (IGF-I) signalling result in increased lifespan and retard ageing. In this chapter, we describe the current research in mammalian systems with respect to the role of insulin or IGF-I in ageing. Using rodent models of caloric restriction and genetic mouse models, e.g. the Ames and Snell dwarf mice, fat-specific insulin receptor knockout mice (FIRKO) and mice that are heterozygous for the IGF-I receptor (Igf1r+/-), investigators have shown that a reduction in plasma levels of insulin and/or IGF-I or reductions in insulin/IGF-I signalling appear to be correlated with increased longevity and retarded ageing.
Richardson
Arlan
A
Department of Cellular and Structural Biology, Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 78229, USA. richardsona@uthscsa.edu
Liu
Feng
F
Adamo
Martin L
ML
Van Remmen
Holly
H
Nelson
James F
JF
D000375:Aging / Q000502:physiology*; D000818:Animals; D004392:Dwarfism; D002149:Energy Intake; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D017526:Receptor, IGF Type 1 / Q000172:deficiency / Q000235:genetics; D011972:Receptor, Insulin / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
D007328:Insulin; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin