Outbreak of mumps in a vaccinated child population: a question of vaccine failure?
In Belgium, children are immunized against measles-mumps-rubella (MMR) in a two-dose schedule at the age of 15 months and 11 years. Despite these recommendations, epidemics of mumps still occur. During an outbreak of mumps in Bruges (Belgium), 105 cases were registered in seven schools (age group 3-12 years). Lower than optimal vaccination coverage, inadequate vaccination schedule and a combination of primary and/or secondary vaccine failure are considered as possible reasons for the outbreak as described in the article. The role of secondary vaccine failure is highlighted.
Vandermeulen
Corinne
C
Department of Youth Health Care, Katholieke Universiteit Leuven, Kapucijnenvoer 35/1, 3000, Belgium. corinne.vandermeulen@med.kuleuven.ac.be
Roelants
Mathieu
M
Vermoere
Marijke
M
Roseeuw
Katelijn
K
Goubau
Patrick
P
Hoppenbrouwers
Karel
K
D001530:Belgium; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D032541:Mass Vaccination; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology; D009107:Mumps / Q000453:epidemiology*; D009108:Mumps Vaccine / Q000276:immunology*; D016017:Odds Ratio; D017211:Treatment Failure
D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine