title: DXS10011: studies on structure, allele distribution in three populations and genetic linkage to further q-telomeric chromosome X markers.
abstract: The hypervariable tetranucleotide STR polymorphism DXS10011 is a powerful marker for forensic purposes. Investigation of this STR led to an allele nomenclature which is in consensus with the ISFG recommendations. DXS10011 is located at Xq28 and genetically closely linked to DXS7423 and DXS8377 but is unlinked to HPRTB and more distant X-chromosomal STRs. DXS10011 is a very complex marker exhibiting some structural variants within alleles of identical length. Two types of repeat structure (regular and inter-alleles) are known and described as types A and B. Two SNPs which are in strong linkage disequilibrium to the different sequence types were found in the repeat flanking region. The type A sequence consists of a long stretch of uninterrupted homogenous repeats which is highly susceptible to slippage mutation during male meiosis.
authors.affiliation: Institut für Rechtsmedizin, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hering
authors.forename: Nicola
authors.initials: N
authors.lastname: Brundirs
authors.forename: Eberhard
authors.initials: E
authors.lastname: Kuhlisch
authors.forename: Jeanett
authors.initials: J
authors.lastname: Edelmann
authors.forename: Ines
authors.initials: I
authors.lastname: Plate
authors.forename: Mark
authors.initials: M
authors.lastname: Benecke
authors.forename: Pham Hung
authors.initials: PH
authors.lastname: Van
authors.forename: Matthias
authors.initials: M
authors.lastname: Michael
authors.forename: Reinhard
authors.initials: R
authors.lastname: Szibor
mesh_terms: D000293:Adolescent; D000328:Adult; D041321:Chromosomes, Human, X / Q000235:genetics*; D022801:Complementarity Determining Regions; D016172:DNA Fingerprinting; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005858:Germany; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010334:Paternity; D010568:Peru; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D014744:Vietnam
chemical_list: D022801:Complementarity Determining Regions; D005819:Genetic Markers