title: A method to quantify the uptake rate of 2-[18F]fluoro-2-deoxy-D-glucose in tissues.
abstract: A two-compartment model is used to derive the tissue time-activity curve of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG). At the later phase of the 18F-FDG activity in the tissue, the model leads to a method which allows the assessment of the 18F-FDG uptake rate constant. The proposed method is both compared with the standard uptake value (SUV) method and with Patlak's graphical analysis.
authors.affiliation: Service de Médecine Nucléaire, Hôpital du Haut_Lévêque, Centre Hospitalo_Universitaire de Bordeaux, Bordeaux, France. elaffon@u_bordeaux2.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Laffon
authors.forename: Michèle
authors.initials: M
authors.lastname: Allard
authors.forename: Roger
authors.initials: R
authors.lastname: Marthan
authors.forename: Dominique
authors.initials: D
authors.lastname: Ducassou
mesh_terms: D000465:Algorithms; D000818:Animals; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D011865:Radioisotope Dilution Technique; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18