Evidence using a shared oocyte pool that the sperm rather than the oocyte in some cases may be responsible for the production of embryos with a high percentage of fragmented blastomeres--case report.
OBJECTIVE
Hypothesis--a sperm defect rather than an oocyte problem may occasionally be responsible for blastomere fragmentation.


METHODS
The morphology of embryos in pairs of women producing embryos from a common pool of oocytes but fertilized by two different sperm sources was performed to see if a pair could be detected where one woman produced embryos with very little blastomere fragmentation vs the other woman having embryos with extensive fragmentation.


RESULTS
An oocyte donor was identified who produced 49 oocytes resulting in 17 embryos for the infertile donor to evaluate and 13 for the recipient. Almost all of the donor embryos showed extensive fragmentation vs very little for the recipient embryos.


CONCLUSIONS
The sperm, in some cases at least, may be the etiologic factor for blastomere fragmentation.
Check
J H
JH
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
Cochrane
H
H
Yuan
W
W
Wilson
C
C
D000328:Adult; D001757:Blastomeres / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D018587:Oocyte Donation; D009865:Oocytes / Q000166:cytology*; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D013084:Sperm-Ovum Interactions