Characteristics of patients diagnosed with AIDS shortly after first detection of HIV antibodies in Lyon University hospitals from 1985 to 2001.
A diagnosis of AIDS shortly after the detection of HIV antibodies suggests a long-lasting course of the disease without care. The factors associated with a short delay between the initial HIV-1-positive test and the first AIDS-defining event were identified in 1901 patients from 1985 to 2001 in Lyon University hospitals. A total of 576 individuals (30.3%) had an interval of </=3 months between the detection of HIV infection and AIDS. The factors independently associated with a delay of </=3 months were: age from 30 to 44 years [odds ratio (OR) 2.5; 95% confidence interval (CI) 1.9-3.2]; age from 45 to 59 years (OR 5.6; 95% CI 3.9-7.8); age >/=60 years (OR 4.5; 95% CI 2.5-8.1), compared to those<30 years old; heterosexuality (OR 2.4; 95% CI 1.6-3.4); injection drug use (OR 2.1; 95% CI 1.5-2.7); and other exposures (OR 2.4; 95% CI 1.6-3.4), compared to homosexual exposure; two opportunistic infections at AIDS (OR 1.8; 95% CI 1.4-2.4) compared to one; and Pneumocystis carinii pneumonia as initial AIDS event (OR 2.6; 95% CI 1.8-3.7), compared to Kaposi's sarcoma. These results provide opportunities to refocus local public health interventions to reduce delayed access to care.
Baratin
D
D
Department of Hygiene, Epidemiology and Prevention, Edouard Herriot Hospital, Lyon, France.
Marceillac
E
E
Trepo
C
C
Cotte
L
L
Peyramond
D
D
Chidiac
C
C
Touraine
J-L
JL
Livrozet
J-M
JM
Fabry
J
J
Allard
R
R
Vanhems
P
P
D015492:AIDS Serodiagnosis; D017088:AIDS-Related Opportunistic Infections; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000635:transmission; D000328:Adult; D000367:Age Factors; D005260:Female; D015497:HIV-1; D020010:Heterosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011020:Pneumonia, Pneumocystis; D012307:Risk Factors; D012737:Sex Factors; D015819:Substance Abuse, Intravenous; D013997:Time Factors