title: Immunity and exposure to hepatitis A virus in pre-adolescent children from a multi-ethnic inner city area.
abstract: Seroprevalence data among ethnic minority groups within England and Wales are rare. An opportunistic approach was taken to test residual oral fluid, collected from pre-adolescent school children from an ethnically diverse region of northwest England, for anti-hepatitis A virus (HAV) IgG. Individual data on ethnicity and country of birth were also available. Of the 257 children who consented to participate, 62% were of South Asian ethnic origin. The overall seroprevalence was 18.8%, higher than 13.1% reported from a recent population-based survey in England and Wales among a mainly Caucasian population of the same age. The only factor significantly associated with HAV seropositivity in a multivariable logistic regression model was birth of the child abroad. Association with the place of birth of the child, but not that of the parent indicates that infection within this group occurs mainly abroad. Larger studies among ethnic minority groups are needed to investigate this claim further.
authors.affiliation: Immunisation Division, Health Protection Agency, London. marianne.c.cunnington@gsk.com
authors.forename: M
authors.initials: M
authors.lastname: Morris-Cunnington
authors.forename: W J
authors.initials: WJ
authors.lastname: Edmunds
authors.forename: E
authors.initials: E
authors.lastname: Miller
mesh_terms: D001211:Asia, Western / Q000208:ethnology; D044466:Asian People / Q000706:statistics & numerical data*; D002648:Child; D002947:Cities; D004739:England / Q000453:epidemiology; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology* / Q000208:ethnology / Q000276:immunology; D035922:Hepatitis A Antibodies / Q000032:analysis; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D016015:Logistic Models; D008297:Male; D012307:Risk Factors; D012463:Saliva / Q000821:virology*; D016036:Seroepidemiologic Studies
chemical_list: D035922:Hepatitis A Antibodies; D007074:Immunoglobulin G