title: Cylindroma of the breast of skin adnexal type: a study of 4 cases.
abstract: Four cases of solitary cylindroma of the breast of skin adnexal type are described. The tumors were morphologically and immunophenotypically identical to their dermal counterparts. They arose in close proximity to the nipple, such as the retroareolar area of the breast and in intimate association with the lactiferous ducts, suggesting an origin from the latter structures. One case occurred in a woman with hereditary multiple cylindromatosis (Brooke-Spiegler syndrome). This is the second reported case of this hereditary syndrome with extracutaneous manifestations and the first case in which the breast is involved.
authors.affiliation: Department of Pathology, National Cancer Institute, Via G. Venezian 1, 20133 Milan, Italy. Daisuke.nonaka@istitutotumori.mi.it
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nonaka
authors.forename: Juan
authors.initials: J
authors.lastname: Rosai
authors.forename: Dominic
authors.initials: D
authors.lastname: Spagnolo
authors.forename: Sergio
authors.initials: S
authors.lastname: Fiaccavento
authors.forename: Michele
authors.initials: M
authors.lastname: Bisceglia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D018294:Neoplasms, Adnexal and Skin Appendage / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome