title: Radiation-induced glioblastoma multiforme in two adult baboons (Papio cynocephalus anubis).
abstract: A diagnosis of glioblastoma multiforme (GBM) was made for cerebral masses found at necropsy in two baboons (Papio cynocephalus anubis). Case 1 was an adult (6.18 years old) male baboon that suddenly died during a physical examination as part of a clinical evaluation for a leg lameness. Case 2 was an adult (5.95 years old) female baboon that stopped breathing during anesthesia for an magnetic resonance imaging to evaluate lethargy, weight loss, inappetence, and dilated pupils. Both animals had undergone total body irradiation with cobalt during a research protocol. The incidence of spontaneous brain tumors in nonhuman primates is low, but radiation-induced GBM lesions in rhesus macaques (Macaca mulatta) have been reported. A definitive diagnosis was made in these cases, using histopathologic criteria of cellular pleomorphism, high mitotic rate, regions of coagulation necrosis, and endothelial proliferation.
authors.affiliation: Washington National Primate Research Center, University of Washington, Seattle, Washington, USA.
authors.forename: Jo Ellen
authors.initials: JE
authors.lastname: Schielke
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Kiem
authors.forename: Denny
authors.initials: D
authors.lastname: Liggitt
authors.forename: Helle
authors.initials: H
authors.lastname: Bielefeldt-Ohmann
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005909:Glioblastoma / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D007794:Lameness, Animal; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000662:veterinary*; D010215:Papio; D018419:Primate Diseases / Q000473:pathology*; D015303:Simian T-lymphotropic virus 1 / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000914:Antibodies, Viral