title: Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effect of subgingival administration of doxycycline as an adjunct to periodontal therapy in type 1 diabetes mellitus (DM) patients.
  
  
  METHODS
  Twenty-two paired periodontal defects > or =5.0 mm were treated in 11 patients (35-55 years old). After initial therapy the sites were randomly assigned into test (scaling and root planing+subgingival administration of 10% doxycycline hyclate gel) or control (scaling and root planing+subgingival placebo gel) groups. The clinical parameters of clinical attachment level (CAL), probing depth (PD) and gingival margin level (GML) for recession determination were assessed at baseline, after 6 weeks, and 6, 9 and 12 months, using a computerized probe. Data were statistically evaluated using Duncan and F tests.
  
  
  RESULTS
  Between study group comparisons indicated PD reduction and CAL gain were greater in the test group than in the control group at 6 weeks and 6, 9 and 12 months but only statistically significant at 12 months (p<0.05). Within study group comparisons indicated statistically significant differences were found for CAL and PD values favouring the adjunctive doxycycline group from baseline to 6 weeks and 6, 9 and 12 months (p<0.05).
  
  
  CONCLUSIONS
  These findings suggest that subgingivally delivered doxycycline hyclate produces additional favorable clinical results to periodontal therapy in type 1 DM patients.
authors.affiliation: Department of Prosthodontics and Periodontics, School of Dentistry, University of Campinas, Piracicaba, SP, Brazil.
authors.forename: Antonio Fernando
authors.initials: AF
authors.lastname: Martorelli de Lima
authors.forename: Cmila Cristina
authors.initials: CC
authors.lastname: Cury
authors.forename: Daniela Bazan
authors.initials: DB
authors.lastname: Palioto
authors.forename: Adhemar Mendes
authors.initials: AM
authors.lastname: Duro
authors.forename: Robert Carvalho
authors.initials: RC
authors.lastname: da Silva
authors.forename: Larry F
authors.initials: LF
authors.lastname: Wolff
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D004311:Double-Blind Method; D004318:Doxycycline / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline