Regulation of activation and recombination of the murine Igkappa locus.
The murine immunoglobulin (Ig) kappa locus has been intensively studied in an attempt to understand its developmentally regulated activation for both transcription and V(D)J recombination. A variety of signaling proteins, cis-acting DNA elements, and trans-acting DNA-binding proteins have been discovered and shown to be involved in the regulated changes in chromatin structure, which are associated with recombinase accessibility. In addition, key roles have been suggested for DNA methylation and replication in kappa-locus expression and rearrangement. This review summarizes data in this area and considers what studies of the murine kappa locus have revealed about the lineage specificity, order, and allelic exclusion of lymphoid V(D)J recombination.
Schlissel
Mark S
MS
University of California, Berkeley, CA 94720-3200, USA. mss@uclink4.berkley.edu
D000818:Animals; D002843:Chromatin / Q000737:chemistry; D019175:DNA Methylation; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism; D004742:Enhancer Elements, Genetic / Q000502:physiology; D005786:Gene Expression Regulation; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain; D005809:Genes, Regulator / Q000502:physiology; D007145:Immunoglobulin kappa-Chains / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D011995:Recombination, Genetic; D015398:Signal Transduction; D045567:VDJ Recombinases / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D004268:DNA-Binding Proteins; D007145:Immunoglobulin kappa-Chains; D045567:VDJ Recombinases