From hemorheology to vascular mechanobiology: An overview.
Almost all of the cells of the human body are subjected to mechanical stresses. In endothelial cells, mechanical stresses can vary from some milli-Pascal (shear stress) to one ore more Pascal (hydrostatic pressure). Now it is know that mechanical stresses have a decisive part cellular physiology. However, if the main biological effects of mechanical stress are well related, the mechanisms allowed the relation between mechanical stress to physiological phenomenon remain nearly unknown (mechanotransduction phenomenon). In this work, through personal results and published works, the authors considers all the effects of mechanical stresses and the possible hypothesis.
Muller
S
S
Mécanique et Ingénierie cellulaire et tissulaire LEMTA UMR CNRS-INPL-UHP 7563 and IFR 111 Bioingénierie CNRS-UHP-INPL-CHU, Faculté de Médecine, 54500 Vandoeuvre Les Nancy, France.
Labrador
V
V
Da Isla
N
N
Dumas
D
D
Sun
R
R
Wang
X
X
Wei
L
L
Fawzi-Grancher
S
S
Yang
W
W
Traore
M
M
Boura
C
C
Bensoussan
D
D
Eljaafari
A
A
Stoltz
J-F
JF
D001808:Blood Vessels / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology; D018056:Hemorheology / Q000639:trends*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology; D013314:Stress, Mechanical