[Prevalence of celiac disease markers in a French cohort of children and adolescents with type 1 diabete mellitus].
The aim of this study was to determine the prevalence of celiac disease (CD) markers in a French cohort of 84 children type 1 diabetics. Detection of antitransglutaminase (AtTG), antiendomysium (AEA) and antigliadin (AGA) antibodies was performed. Group 1 included 81 (96.4%) diabetic patients with negative antibodies. Group 2 included 3 patients (3.6%) with positive serological markers: 1 AGA-AEA-AtTG and 1 AEA-AtTG with proved histological diagnosis and 1 AGA positive with negative histology. No statistically significant difference was observed between the groups with regard to age, duration of diabetes, familial target stature, and ratios Height/Age and Weight/Height. Presence of CD serological markers was related to a lower level of HbA1c. Prevalence of CD serological markers is important in this French cohort but lower than other countries.
Beltran
S
S
Service de pédiatrie médicale et médecine de l'adolescent, unité de diabétologie, hôpital Nord, 80054 Amiens Cedex 1, France. sonia.beltran@wanadoo.fr
Bony-Trifunovic
H
H
Gouilleux-Gruart
V
V
Djeddi
D
D
Dadamessi
I
I
Dupas
J L
JL
Boudailliez
B
B
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000276:immunology; D005602:France; D005903:Gliadin / Q000276:immunology; D006801:Humans; D011503:Transglutaminases / Q000276:immunology
D001323:Autoantibodies; D015415:Biomarkers; D005903:Gliadin; D011503:Transglutaminases