Resistant Candida parapsilosis associated with long term fluconazole prophylaxis in an animal model.
We report an increased occurrence of fluconazole-resistant Candida parapsilosis after a 4-year period of antifungal prophylaxis in a premature animal neonatal intensive care unit. Although prevention of nosocomial fungal infections in premature infants is desirable, implementation of fluconazole prophylaxis should be undertaken with caution. Where such programs are in place, evaluation of fungal isolates for drug resistance should be considered.
Yoder
Bradley A
BA
Department of Medicine and Physiology, Southwest Foundation for Biomedical Research, University of Texas Health Science Center, San Antonio, Texas, USA.
Sutton
Deanna A
DA
Winter
Vicki
V
Coalson
Jacqueline J
JJ
D000818:Animals; D000831:Animals, Newborn; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000382:microbiology; D004195:Disease Models, Animal; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D010215:Papio
D000935:Antifungal Agents; D015725:Fluconazole