The role of death-associated molecular patterns in the pathogenesis of systemic lupus erythematosus.
This article describes apoptotic cell clearance mechanisms and discusses altered mechanisms for clearance of dying material, which represents a central pathogenic process in the development and acceleration of systemic lupus erythematosus. The article also explores ways to use this perspective for a potential direction for future treatments.
Mevorach
Dror
D
Laboratory for Cellular and Molecular Immunology, Rheumatology Unit, Department of Medicine, Hadassah-Hebrew University, POB 12000, Kiryat Hadassah, Jerusalem 91200, Israel. mevorachd@hadassah.org.il
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000503:physiopathology*; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology*