Mechanism of action of antiatherogenic and related effects of Ficus bengalensis Linn. flavonoids in experimental animals.
One month treatment of alloxan diabetic dogs with a glycoside, viz. leucopelargonin derivative (100 mg/kg/day) isolated from the bark of F. bengalensis decreased fasting blood sugar and glycosylated haemoglobin by 34% and 28% respectively. Body weight was maintained in both the treated groups while the same was decreased significantly by 10% in the control group. In cholesterol diet fed rats, as the atherogenic index and the hepatic bile acid level and the faecal excretion of bile acids and neutral sterols increased, the HMGCoA reductase and lipogenic enzyme activities in liver and lipoprotien lipase activity in heart and adipose tissue and plasma LCAT activity and the incorporation of labelled acetate into free and ester cholesterol in liver decreased significantly. On treatment with the two ficus flavonoids, viz. leucopelargonin and leucocyanin derivatives and another flavonoid quercetin (100 mg/kg/day) the above said effects except on bile acids and sterols and lipogenic enzymes were significantly reversed in the cholesterol fed rats. However in the treated rats the hepatic level of bile acids and the faecal excretion of bile acids and neutral sterols still further increased and the action of lipogenic enzyme glucose 6 phosphate dehydrogenase was still further decreased. These effects of leucopelargonidin and quercetin were better than that of the second. Toxicity studies are required to be carried out to find out if the ficus flavonoids could be used as health promoters as they are hypocholesterolemic and antioxidant in action.
Daniel
Regi Susan
RS
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695 581, India.
Devi
K S
KS
Augusti
K T
KT
Sudhakaran Nair
C R
CR
D000818:Animals; D000872:Anthocyanins / Q000302:isolation & purification / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000517:prevention & control*; D001647:Bile Acids and Salts / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004285:Dogs; D030681:Ficus / Q000737:chemistry*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000872:Anthocyanins; D001647:Bile Acids and Salts; D001786:Blood Glucose; D002791:Cholesterol, Dietary; D006442:Glycated Hemoglobin; D000960:Hypolipidemic Agents; C087775:leucopelargonin