title: Great saphenous vein leiomyosarcoma: a rare malignant tumor of the extremity--two case reports.
abstract: Peripheral vascular leiomyosarcomas are rare. Two cases of intramural leiomyosarcomas of the great saphenous vein are described. The first case is considered a high-grade sarcoma, based on the high mitotic index on histologic study. The second case presents only infrequent mitoses on light microscopy. Immunohistochemical analysis for factor VIII helped to establish the diagnosis. Characteristics of the tumor and differential diagnosis are discussed. Treatment consisted of wide local excision. Radiotherapy and chemotherapy were given to the patient with high-grade tumor.
authors.affiliation: Department of Vascular Surgery, Clinique Font Redonde, Figeac, France. thucleminh@aol.com
authors.forename: Thuc
authors.initials: T
authors.lastname: Le Minh
authors.forename: Didier
authors.initials: D
authors.lastname: Cazaban
authors.forename: Jean
authors.initials: J
authors.lastname: Michaud
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Ginestet-Auge
authors.forename: Marie Hélène
authors.initials: MH
authors.lastname: Laporte
authors.forename: Annie
authors.initials: A
authors.lastname: Patelli
authors.forename: Alain
authors.initials: A
authors.lastname: Marre
mesh_terms: D000368:Aged; D000783:Aneurysm / Q000175:diagnosis / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D012501:Saphenous Vein / Q000473:pathology* / Q000601:surgery; D018608:Ultrasonography, Doppler; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000628:therapy; D014656:Vascular Surgical Procedures; D020246:Venous Thrombosis / Q000175:diagnosis / Q000628:therapy