3,5-Nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages.
3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC(50)=6.7+/-0.8 microM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.
Doković
Dejan D
DD
Faculty of Chemistry, University of Belgrade, Serbia and Montenegro. dejandj@chem.bg.ac.yu
Bulatović
Vanja M
VM
Bozić
Biljana D
BD
Kataranovski
Milena V
MV
Zrakić
Tomislav M
TM
Kovacević
Nada N
NN
D000480:Alkynes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D019661:Apiaceae; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D027343:Rhizome
D000480:Alkynes; D009822:Oils, Volatile; D009569:Nitric Oxide