title: Effect of haemodialysis on retinal circulation in patients with end stage renal disease.
abstract: OBJECTIVE
  To investigate the effect of haemodialysis on retinal circulation in patients with end stage renal disease (ESRD).
  
  
  METHODS
  Seventeen consecutive patients with ESRD were recruited into the study. The authors simultaneously measured changes in vessel diameter and blood velocity and calculated the retinal blood flow (RBF) in the retinal veins in patients with ESRD before and after haemodialysis using a laser Doppler velocimetry system. In addition, the relations between the changes in systemic and retinal circulatory parameters were examined.
  
  
  RESULTS
  There was a group averaged increase in vessel diameter (p = 0.003) after haemodialysis. However, the blood velocity and RBF values obtained after haemodialysis were not significantly different from those before haemodialysis (p = 0.66 and p = 0.63, respectively). The changes in vessel diameter were negatively (r = -0.549, p = 0.02) correlated with the change in MABP, but the changes in blood velocity and RBF were positively correlated with the change in MABP (r = 0.683, p<0.002 and r = 0.589, p<0.01, respectively). The change in RBF was also inversely correlated with the increase in haematocrit (r = -0.693, p<0.002) and the amount of fluid removed (r = -0.597, p<0.01).
  
  
  CONCLUSIONS
  The results indicate that haemodialysis and the associated changes in systemic circulatory parameters may affect the retinal circulation in patients with ESRD.
authors.affiliation: Department of Ophthalmology, Asahikawa Medical College, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510, Japan. nagaoka@asahikawa-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Nagaoka
authors.forename: Y
authors.initials: Y
authors.lastname: Takeyama
authors.forename: S
authors.initials: S
authors.lastname: Kanagawa
authors.forename: K
authors.initials: K
authors.lastname: Sakagami
authors.forename: F
authors.initials: F
authors.lastname: Mori
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006400:Hematocrit; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D006435:Renal Dialysis / Q000009:adverse effects*; D012171:Retinal Vessels / Q000473:pathology / Q000503:physiopathology*