Prognostic importance of renal function in patients with early heart failure and mild left ventricular dysfunction.
We evaluated the prognostic value of renal function in an initially "untreated" population with mild heart failure and compared the prognosis of this population with a matched controlled population. During a follow-up of 13 years (mean 11.7), 90 patients (56%) died. Mortality was higher compared with a matched controlled population. Multivariate Cox regression analysis demonstrated that beside the well-established risk markers of left ventricular ejection fraction and heart rate, renal function (estimated glomerular filtration rate, hazard ratio 1.16/10 ml/min/1.73 m(2), p = 0.003) was the only additional independent predictor of cardiovascular mortality in patients with early heart failure.
Smilde
Tom D J
TD
Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands. t.d.j.smilde@thorax.azg.nl
Hillege
Hans L
HL
Voors
Adriaan A
AA
Dunselman
Peter H J
PH
Van Veldhuisen
Dirk J
DJ
D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000401:mortality* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015999:Multivariate Analysis; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D018487:Ventricular Dysfunction, Left / Q000401:mortality* / Q000503:physiopathology