Effects of garlic (Allium sativum) extract on the heart rate, rhythm and force of contraction in frog: a dose-dependent study.
Garlic juice (dose equivalent to 3.3 g to 33 g garlic) mainly caused bradycardia in frog Rana tigerina. The disturbance in ventricular rhythm was observed prior to than that of atria. Rhythm was specially disturbed at higher doses causing bizarre pattern. Force of contraction of the heart also decreased with higher dose of the garlic extract. The results suggest that garlic extract has some beneficial effect on heart rate modulating the rate, rhythm and force of contraction positively but very high doses may exert non-desirable effects as well.
Yadav
Raj Kumar
RK
Department of Physiology, King George's Medical College, Lucknow 226 003, India. rajkumaryad@hotmail.com
Verma
Nar Singh
NS
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005609:Free Radicals; D005737:Garlic / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D008956:Models, Chemical; D009119:Muscle Contraction; D009200:Myocardial Contraction / Q000187:drug effects*; D010936:Plant Extracts; D011898:Ranidae
D005609:Free Radicals; D010936:Plant Extracts