title: Health outcomes among patients receiving oseltamivir.
abstract: OBJECTIVE
  Oseltamivir was approved by the FDA for the treatment of influenza in 1999. The primary objective was to compare health outcomes among influenza patients who were treated with oseltamivir and those who were not.
  
  
  METHODS
  The patient population included UnitedHealthcare members who received an influenza diagnosis during the 1999-2000 influenza season, divided into those who were dispensed oseltamivir on the same day (N = 3211) and those who were not dispensed oseltamivir (N = 19,985). Cardiovascular, neuropsychiatric and respiratory outcomes were assessed from medical claims for a 30-day period.
  
  
  RESULTS
  The adjusted incidence rate ratio for major cardiac outcome was 0.56 (95%CI: 0.34-0.93) in those without a positive history of major cardiac disease, indicating that those in the oseltamivir group tended to be at lower risk of cardiac outcomes than those without oseltamivir. The adjusted incidence rate ratio for major neuropsychiatric outcome was 0.72 (95%CI: 0.53-0.97) in the negative history of neuropsychiatric disease stratum. The incidence rate ratios for respiratory events were more variable.
  
  
  CONCLUSIONS
  There appears to be no increased risk of cardiac or neuropsychiatric outcomes among subjects with influenza who were treated with oseltamivir in comparison with those who were not.
authors.affiliation: Ingenix Epidemiology, Auburndale, MA 02466, USA.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Enger
authors.forename: Beth L
authors.initials: BL
authors.lastname: Nordstrom
authors.forename: Bharat
authors.initials: B
authors.lastname: Thakrar
authors.forename: Susan
authors.initials: S
authors.lastname: Sacks
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Rothman
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy*; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced; D008875:Middle Aged; D053139:Oseltamivir; D012140:Respiratory Tract Diseases / Q000139:chemically induced
chemical_list: D000081:Acetamides; D000998:Antiviral Agents; D053139:Oseltamivir