title: Ubiquitous p63 expression in human esophageal squamous cell carcinoma.
abstract: p63, a recently identified member of the p53 gene family, plays an important role in human tissue functions. We examined the pattern of p63 expression in human esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. Immunoreactivity for p63 was detected in 96.9% (63/65) esophageal squamous cell carcinomas. Diffuse p63 expression was seen in 75.4% (49/65). p63 was detected not only in the in situ carcinomatous components or intramucosal carcinomas, but also in the invasive carcinomatous parts of the p63-positive cases. There were no significant correlations between p63 expression and clinicopathological features, such as depth of tumor invasion, tumor differentiation, lymph node metastasis and venous/lymphatic invasion. We also analyzed the relationship between p63 and p53 expression in esophageal squamous cell carcinomas. These results suggest that the p63 gene, as well as the p53 gene, play a major role in the carcinogenesis of human esophageal squamous cells and in the growth of the carcinoma.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kenmochi
authors.forename: Yosifumi
authors.initials: Y
authors.lastname: Kise
authors.forename: Hikaru
authors.initials: H
authors.lastname: Tanaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Chino
authors.forename: Hideo
authors.initials: H
authors.lastname: Shimada
authors.forename: Kensuke
authors.initials: K
authors.lastname: Takazawa
authors.forename: Makiko
authors.initials: M
authors.lastname: Tanaka
authors.forename: Sadaki
authors.initials: S
authors.lastname: Inokuchi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D049109:Cell Proliferation; D004268:DNA-Binding Proteins; D004938:Esophageal Neoplasms / Q000378:metabolism*; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010750:Phosphoproteins / Q000096:biosynthesis* / Q000502:physiology*; D013997:Time Factors; D015534:Trans-Activators / Q000096:biosynthesis* / Q000502:physiology*; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D025521:Tumor Suppressor Proteins
chemical_list: D004268:DNA-Binding Proteins; D010750:Phosphoproteins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins