title: [Negative D-dimers and peripheral pulmonary embolism].
abstract: The measurement of D-dimers is a recent addition to the diagnostic strategy of pulmonary embolism and has been shown to be a valuable tool with excellent sensitivity. However, there have been rare reports of patients with pulmonary embolism but negative D-dimer tests. The object of this study was to study patients with pulmonary embolism but negative D-dimers and to compare them with a population of patients with pulmonary embolism and raised D-dimers. One hundred and fifty consecutive patients admitted for pulmonary embolism were included in this study. All underwent measurement of D-dimers (normal <500 ng/ml) by an ELISA technique. The data of clinical examination and complementary investigations were analysed with respect to the D-dimers result. The sensitivity of raised D-dimers for pulmonary embolism was 96% (6 patients had results <500 ng/ml). The finding of chest pain was statistically greater in the group with negative D-dimers (p=0.01). In these cases, the emboli were all distal (p=0.0003), the average Miller index was significantly lower than in patients with high D-dimers (p=0.04) and the diagnostic value of ultrasound investigations (echocardiography, ultrasonography of lower limb veins) was less (p<0.0001). The authors conclude that measurement of D-dimers by the ELISA method may be non-diagnostic in distal pulmonary embolism and one explanation could be the less extensive thromboembolic process. In cases with negative D-dimers, a strong clinical suspicion of pulmonary embolism should lead to the request for further investigations.
authors.affiliation: Service de cardiologie, Assistance Publique-Hôpitaux de Paris, hôpital Ambroise Paré, Boulogne. nicolas.mansencal@apr.ap-hop-paris.fr
authors.forename: N
authors.initials: N
authors.lastname: Mansencal
authors.forename: T
authors.initials: T
authors.lastname: Joseph
authors.forename: A
authors.initials: A
authors.lastname: Vieillard-Baron
authors.forename: M
authors.initials: M
authors.lastname: El Hajjam
authors.forename: M
authors.initials: M
authors.lastname: Bendaoud
authors.forename: A
authors.initials: A
authors.lastname: Drouin
authors.forename: G
authors.initials: G
authors.lastname: Jondeau
authors.forename: P
authors.initials: P
authors.lastname: Lacombe
authors.forename: F
authors.initials: F
authors.lastname: Jardin
authors.forename: O
authors.initials: O
authors.lastname: Dubourg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000097:blood*; D015203:Reproducibility of Results
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D