title: Effect of a hypocaloric diet on lipids and rheological profile in subjects with severe and morbid obesity. A follow-up study.
abstract: Discrepant results have been published regarding modifications of rheological parameters in obese subjects after a low caloric diet (LCD). In order to ascertain whether a decrease in BMI associated to a LCD, is accompanied by changes in the hemorheological parameters, we determined in 41 morbid obese subjects (32 female, 9 male aged 33+/-10 years) BMI, glucose, plasmatic lipids and apolipoproteins, fibrinogen, blood viscosity (Brookfield viscosimeter), plasma viscosity (Fresenius capillary viscosimeter), erythrocyte aggregation (Myrenne aggregometer), hematocrit and erythrocyte indexes, before starting on a LCD and 1 and 3 months after. During the first month obese subjects received a very low caloric diet (VLCD) (Modifast) providing 458 kcal per day. The second and third month they received a LCD providing 1500 kcal/day for men and 1200 kcal/day for women. One month after starting on a VLCD, a statistical significant decrease in glucose (p<0.001), Total-cholesterol (p<0.001), LDL-cholesterol (p<0.001), triglycerides (p=0.012), apoB (p<0.001) and erythrocyte aggregation (p<0.001) were observed together with a concomitant decrease in BMI (p<0.001). The expected decrease in HDL-cholesterol associated with a low fat diet was also noted in these individuals. No changes in fibrinogen, hematocrit, blood viscosity or plasma viscosity were observed. At 3 months only a slight increase in BMI was observed regarding the one month period, glucose being the only parameter which remained statistically lower. All the other significant parameters returned to their basal values at 3 months. VLCD (Modifast) is associated to a significant decrease in BMI with the corresponding improvement in glucose, lipids and erythrocyte aggregation at one month. However a LCD alone does not produce a further decrease in weight and both lipids and erythrocyte aggregation return to the basal situation at three months.
authors.affiliation: Endocrinology Service, Dr. Peset Hospital, Valencia, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Solá
authors.forename: Amparo
authors.initials: A
authors.lastname: Vayá
authors.forename: Teresa
authors.initials: T
authors.lastname: Contreras
authors.forename: Cristina
authors.initials: C
authors.lastname: Falcó
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
authors.forename: Antonio
authors.initials: A
authors.lastname: Hernández
authors.forename: Justo
authors.initials: J
authors.lastname: Aznar
mesh_terms: D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005500:Follow-Up Studies; D006400:Hematocrit; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D009767:Obesity, Morbid / Q000097:blood* / Q000503:physiopathology; D015431:Weight Loss
chemical_list: D008055:Lipids; D008074:Lipoproteins; D005340:Fibrinogen; D002784:Cholesterol