Phenylhomophthalimide-type NOS inhibitors derived from thalidomide.
Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.
Noguchi
Tomomi
T
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Sano
Hiroko
H
Shimazawa
Rumiko
R
Tanatani
Aya
A
Miyachi
Hiroyuki
H
Hashimoto
Yuichi
Y
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D010797:Phthalimides / Q000737:chemistry / Q000494:pharmacology*; D013792:Thalidomide / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; C496608:Phenylhomophthalimide; D010797:Phthalimides; D013792:Thalidomide; D019001:Nitric Oxide Synthase