title: Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?
abstract: Nitric oxide (NO) is a short-life key bioregulatory active molecule in the cardiovascular, immune and nervous systems. NO is synthesized by converting L-arginine to L-citrulline by enzymes called NO synthase (NOS). The growing body of evidence strongly supports the theory that this molecule appears to be one of the key targets for the disruption of normal brain homeostasis, which causes the development of brain lesions and pathology such as in Alzheimer's disease (AD) or other related dementia. The vascular content of NO activity appears especially to be a main contributor to this pathology before the over-expression of other NOS isoforms activity in a different brain cellular compartment. We speculate that pharmacological intervention using NO donors and/or NO suppressors will be able to delay or minimize the development of brain pathology and further progression of mental retardation.
authors.affiliation: Microscopy Research Center, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Aliyev
authors.forename: Dilara
authors.initials: D
authors.lastname: Seyidova
authors.forename: Nizami
authors.initials: N
authors.lastname: Rzayev
authors.forename: Mark E
authors.initials: ME
authors.lastname: Obrenovich
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Lamb
authors.forename: Shu G
authors.initials: SG
authors.lastname: Chen
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: George
authors.initials: G
authors.lastname: Perry
authors.forename: Jack C
authors.initials: JC
authors.lastname: de la Torre
authors.forename: Gjumrakch
authors.initials: G
authors.lastname: Aliev
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D002536:Cerebral Arteries / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000201:enzymology* / Q000503:physiopathology; D015140:Dementia, Vascular / Q000150:complications / Q000201:enzymology / Q000503:physiopathology; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology / Q000627:therapeutic use; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology
chemical_list: D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase