Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis.
Mastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.
Escribano
Luis
L
Unidad de Mastocytosis, Laboratorio K. Frank Austen, Hospital Ramón y Cajal, Madrid, Spain. lescribano.hrc@salud.madrid.org
Garca-Montero
Andrés
A
Núñez-López
Rosa
R
López-Jiménez
Javier
J
Almeida
Julia
J
Prados
Aranzazu
A
Orfao
Alberto
A
D000368:Aged; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy