Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(II) complex.
The axial aqua bound copper(II) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 +/- 0.4 h(-1) and a rate enhancement of 1.55 x 10(8).
Dhar
Shanta
S
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.
Reddy
Pattubala A N
PA
Chakravarty
Akhil R
AR
D004278:DNA, Superhelical / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D006868:Hydrolysis; D007700:Kinetics; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011810:Quinoxalines / Q000737:chemistry*
D004278:DNA, Superhelical; D009942:Organometallic Compounds; D011810:Quinoxalines; C460959:dipyridoquinoxaline copper(II) complex