title: Intraventricular craniopharyngiomas: topographical classification and surgical approach selection based on an extensive overview.
abstract: BACKGROUND
  This retrospective study analyzes the clinical, neuroradiological, pathological and surgical characteristics of well-described intraventricular craniopharyngiomas with the aims of: (i) critically to review the criteria used to affirm the diagnosis of an intraventricular location (ii) defining more accurately this topographical diagnosis preoperatively, and (iii) to investigate factors influencing the surgical outcome.
  
  
  METHODS
  Clinical, neuroradiological, pathological and surgical objective data of 104 well-described intraventricular craniopharyngiomas (IVC) reported in the literature, in addition to a new case, were analyzed. On the basis of the proofs provided for third ventricle intactness, a new topographical classification for IVC was developed, distinguishing between: (i) strict IVC, with a proved third ventricle floor integrity and (ii) non-strict IVC, without any reliable proof confirming the intactness of the third ventricle floor. Following this classification, clinical features, pathology and surgical outcome for strictly and non-strictly IVC were compared.
  
  
  RESULTS
  For 105 IVC compiled, 36 belonged to the strictly group and 69 to the non-strictly group. Two pathological features were associated with the non-strictly IVC group: a preferentially adamantinomatous pattern (p=0.106) and wider and tighter adherences to third ventricle margins (p=0.01). The non-strict topography was also associated with a worse postoperative outcome (p=0.046). There was a significant relationship between the surgical approach and the final outcome (p=0.05), being the translamina terminalis approach associated with the best outcome.
  
  
  CONCLUSIONS
  Two different topographies might be considered among IVC: strict and non-strict intraventricular location. Non-strictly IVC have wider and tighter adhesions to third ventricle boundaries and this subtype is associated with a worse outcome.
authors.affiliation: Department of Neurosurgery, La Princesa University Hospital, Madrid, Spain. jmpasncj@hotmail.com
authors.forename: J M
authors.initials: JM
authors.lastname: Pascual
authors.forename: F
authors.initials: F
authors.lastname: González-Llanos
authors.forename: L
authors.initials: L
authors.lastname: Barrios
authors.forename: J M
authors.initials: JM
authors.lastname: Roda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002551:Cerebral Ventricle Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000145:classification / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011859:Radiography; D012189:Retrospective Studies; D020542:Third Ventricle / Q000000981:diagnostic imaging / Q000473:pathology*; D016896:Treatment Outcome