Overview of lipoprotein metabolism: mechanisms involved and conveying this information to patients.
The major classes of lipoprotein particles are chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and high-density lipoproteins. Each of these particles has distinct characteristics, including a distinct apolipoprotein composition. The basic functions of these major apolipoproteins are briefly summarized for clinicians, and disorders of lipoprotein metabolism are discussed. For the effective management of lipid disorders, the therapy should be tailored to the specific defect. Compliance may be improved if the patient understands the nature of the particular lipid problem. To that end, we have developed an analogy in which the various classes of lipoprotein particles are equated to different trucking systems, and the liver is considered a warehouse for storage and distribution of fat. With use of this explanation, patients may understand the rationale for selection of various therapeutic strategies, and treatment of the hyper-lipoproteinemia is likely to be more successful.
Kottke
B A
BA
Watson Clinic, Lakeland, Florida, USA.
Nguyen
T T
TT