title: Malignant evolution of monoclonal gammopathy of undetermined significance: analysis of 633 consecutive cases with a long term follow-up.
abstract: In 633 consecutive patients with monoclonal gammopathy of undetermined significance (MGUS) the probability of malignant evolution was 9, 17 and 51 % at 5, 10 and 15 years, respectively, after diagnosis. The values of monoclonal component, Bence-Jones proteinuria and erythrocyte sedimentation rate were associated with malignant transformation.
authors.forename: Dino
authors.initials: D
authors.lastname: Veneri
authors.forename: Haytham
authors.initials: H
authors.lastname: Aqel
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.forename: Mauro
authors.initials: M
authors.lastname: Krampera
authors.forename: Roberta
authors.initials: R
authors.lastname: Zanotti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pizzolo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000453:epidemiology / Q000473:pathology*; D013997:Time Factors