title: Is benign rolandic epilepsy genetically determined?
abstract: Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0-0.4) for BRE compared with 0.7 (95% CI, 0.5-0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored.
authors.affiliation: Epilepsy Research Centre, Department of Medicine (Neurology), University of Melbourne, Austin Health, Australia.
authors.forename: Lata
authors.initials: L
authors.lastname: Vadlamudi
authors.forename: A Simon
authors.initials: AS
authors.lastname: Harvey
authors.forename: Mary M
authors.initials: MM
authors.lastname: Connellan
authors.forename: Roger L
authors.initials: RL
authors.lastname: Milne
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Ingrid E
authors.initials: IE
authors.lastname: Scheffer
authors.forename: Samuel F
authors.initials: SF
authors.lastname: Berkovic
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*