title: Vascular hemichorea/hemiballism and topiramate.
abstract: Although vascular hemichorea/hemiballism (HC/HB) has been reported to be self-limited, in some cases, it can be irreversible and severely disabling. The standard treatment includes typical and atypical neuroleptics and GABA-mimetic drugs. Topiramate is a new antiepileptic drug possessing a complex mechanism of action, including the enhancement of GABA-mediated inhibition. We describe a 71-year-old patient with HC/HB who markedly improved after topiramate treatment.
authors.affiliation: Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Emilia Mabel
authors.initials: EM
authors.lastname: Gatto
authors.affiliation: Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Claudia
authors.initials: C
authors.lastname: Uribe Roca
authors.affiliation: Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Raina
authors.affiliation: Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Gorja
authors.affiliation: Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Silvia
authors.initials: S
authors.lastname: Folgar
authors.affiliation: Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Federico E
authors.initials: FE
authors.lastname: Micheli
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D001479:Basal Ganglia / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D002819:Chorea / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D020820:Dyskinesias / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020521:Stroke / Q000473:pathology / Q000503:physiopathology; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose