Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction.
Intracellular transport by microtubule-dependent motors is crucial for neuronal survival and function. Recent advances reveal novel strategies for the regulation of transport and the attachment of motors to cargoes. Current findings also illustrate the importance of directed transport in neuronal biology, including microtubule-motor-dependent transduction of neurotrophic signals and axonal damage signal complexes. Furthermore, recent data implicating the dysfunction of microtubule-dependent transport in the cause and development of several neurodegenerative diseases provides evidence for the vital role of transport in neuronal and organismal function.
Guzik
Brian W
BW
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093-0683, USA.
Goldstein
Lawrence S B
LS
D000818:Animals; D001370:Axonal Transport; D001692:Biological Transport; D000072159:Dynactin Complex; D006801:Humans; D000071058:Huntingtin Protein; D016547:Kinesins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological; D009046:Motor Neurons / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism; D021382:Protein Sorting Signals; D015290:Second Messenger Systems; D015398:Signal Transduction
D000072159:Dynactin Complex; C086055:HTT protein, human; D000071058:Huntingtin Protein; C094065:KIF1A protein, human; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D021382:Protein Sorting Signals; D016547:Kinesins