title: Mining MEDLINE for implicit links between dietary substances and diseases.
abstract: BACKGROUND
  Text mining systems aim at knowledge discovery from text collections. This work presents our text mining algorithm and demonstrates its use to uncover information that could form the basis of new hypotheses. In particular, we use it to discover novel uses for Curcuma longa, a dietary substance, which is highly regarded for its therapeutic properties in Asia.
  
  
  RESULTS
  Several disease were identified that offer novel research contexts for curcumin. We analyze select suggestions, such as retinal diseases, Crohn's disease and disorders related to the spinal cord. Our analysis suggests that there is strong evidence in favor of a beneficial role for curcumin in these diseases. The evidence is based on curcumin's influence on several genes, such as COX-2, TNF-alpha, JNK, p38 MAPK and TGF-beta. This research suggests that our discovery algorithm may be used to suggest novel uses for dietary and pharmacological substances. More generally, our text mining algorithm may be used to uncover information that potentially sheds new light on a given topic of interest.
  
  
  BACKGROUND
  Contact authors.
authors.affiliation: School of Library and Information Science, University of Iowa, Iowa City, IA 52242, USA. padmini-srinivasan@uiowa.edu
authors.forename: Padmini
authors.initials: P
authors.lastname: Srinivasan
authors.forename: Bisharah
authors.initials: B
authors.lastname: Libbus
mesh_terms: D000043:Abstracting and Indexing / Q000379:methods; D001185:Artificial Intelligence; D003424:Crohn Disease / Q000178:diet therapy*; D003474:Curcumin / Q000627:therapeutic use*; D004035:Diet Therapy; D006801:Humans; D016239:MEDLINE; D009323:Natural Language Processing; D012164:Retinal Diseases / Q000178:diet therapy*; D013118:Spinal Cord Diseases / Q000178:diet therapy*; D013223:Statistics as Topic
chemical_list: D003474:Curcumin