title: Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
abstract: Lipoxygenases (LO) have been implicated in asthma, immune disorders, and various cancers. As a consequence of these broad biological implications, there is great interest in understanding the effects of naturally occurring and environmental contaminants against its activity. On the basis of our earlier studies indicating that polybrominated diphenol ethers are potent inhibitors to mammalian 15-LO, we expanded our structure-activity study to include marine-derived brominated phenol ethers (including a newly discovered tribrominated diphenyl ether), dioxins, and bastadins, as well as the synthetic brominated fire retardants, brominated bisphenol A (BBPA), and polybrominated diphenyl ethers (PBDEs). We report herein the effects of 21 simple and complex organobromine compounds against human platelet 12-LO, human reticulocyte 15-LO, and soybean 15-LO-1.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.
authors.forename: Erika N
authors.initials: EN
authors.lastname: Segraves
authors.forename: Rachana R
authors.initials: RR
authors.lastname: Shah
authors.forename: Nathaniel L
authors.initials: NL
authors.lastname: Segraves
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Johnson
authors.forename: Stephanie
authors.initials: S
authors.lastname: Whitman
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Sui
authors.forename: Victor A
authors.initials: VA
authors.lastname: Kenyon
authors.forename: Robert H
authors.initials: RH
authors.lastname: Cichewicz
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Holman
mesh_terms: D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000737:chemistry; D001093:Arachidonate 15-Lipoxygenase / Q000737:chemistry; D001792:Blood Platelets / Q000737:chemistry; D004147:Dioxins / Q000737:chemistry; D004785:Environmental Pollutants / Q000032:analysis*; D005411:Flame Retardants / Q000032:analysis; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors; D010636:Phenols / Q000737:chemistry; D010647:Phenyl Ethers / Q000737:chemistry; D011075:Polybrominated Biphenyls / Q000737:chemistry; D011161:Porifera; D012156:Reticulocytes / Q000737:chemistry; D013025:Glycine max; D013329:Structure-Activity Relationship
chemical_list: D004147:Dioxins; D004785:Environmental Pollutants; D005411:Flame Retardants; D006842:Hydrocarbons, Brominated; D016859:Lipoxygenase Inhibitors; D010636:Phenols; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase