[Phosphorylation of tau and Alzheimer's disease].
Tau is an important component of neuronal cytosqueleton; the protein stabilizas microtubules, maintains cell shape and axonal transport mechanisms. However, for unknown reasons tau experiments important postranslation modifications including enhanced phosphorilation due to unbalanced activity between kinases and phosphatases, affecting its normal biological function. Under these circumstances tau begins to aggregate into neurofibrillary tangles (NFTS) complexes which are pathological hallmarks of Alzheimer's disease together with senile plaques. This review is mainly concerned with the role that different kinase play into the regulation of tau structure and function.
García
Teresa
T
Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología Ignacio Chávez.
Jay
David
D
D000544:Alzheimer Disease / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism*
D016875:tau Proteins; D010770:Phosphotransferases