title: Can we continue research in splenectomized dogs? Mycoplasma haemocanis: old problem--new insight.
abstract: We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock study. The clinical course of the dogs was dramatic including anorexia and hemolytic anemia. Treatment included allogeneic transfusion, prednisone, and oxytetracycline. Systematic follow-up (n = 12, blood smears, antibody testing and specific polymerase chain reaction) gives clear evidence that persistent eradication of M. haemocanis is unlikely. We, therefore, had to abandon the intended shock study. In the absence of effective surveillance and screening for M. haemocanis, the question arises whether it is prudent to continue shock research in splenectomized dogs.
authors.affiliation: Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilian University Munich, Munich, Germany. Gregor.Kemming@med.uni-muenchen.de
authors.forename: G
authors.initials: G
authors.lastname: Kemming
authors.forename: J B
authors.initials: JB
authors.lastname: Messick
authors.forename: W
authors.initials: W
authors.lastname: Mueller
authors.forename: G
authors.initials: G
authors.lastname: Enders
authors.forename: F
authors.initials: F
authors.lastname: Meisner
authors.forename: S
authors.initials: S
authors.lastname: Muenzing
authors.forename: H
authors.initials: H
authors.lastname: Kisch-Wedel
authors.forename: A
authors.initials: A
authors.lastname: Schropp
authors.forename: C
authors.initials: C
authors.lastname: Wojtczyk
authors.forename: K
authors.initials: K
authors.lastname: Packert
authors.forename: K
authors.initials: K
authors.lastname: Messmer
authors.forename: E
authors.initials: E
authors.lastname: Thein
mesh_terms: D000818:Animals; D004196:Disease Outbreaks; D004283:Dog Diseases / Q000453:epidemiology / Q000382:microbiology*; D004285:Dogs; D005060:Europe; D023421:Models, Animal; D009175:Mycoplasma Infections / Q000453:epidemiology / Q000662:veterinary*; D011183:Postoperative Complications / Q000453:epidemiology / Q000662:veterinary; D015995:Prevalence; D012771:Shock, Hemorrhagic; D013156:Splenectomy