Ca2+ regulation of inositol 1,4,5-trisphosphate receptors: can Ca2+ function without calmodulin?
All Ca(2+) channels are regulated by Ca(2+), a feature that allows them to respond to their own activity and to the activities of neighboring Ca(2+) channels. Inhibition by Ca(2+) protects cells from potentially hazardous increases in cytosolic [Ca(2+)], and stimulation can mediate facilitation and regenerative propagation of Ca(2+) signals. Calmodulin is emerging as a key player in regulation of Ca(2+) channels by Ca(2+), but its role is more complex and more beautiful than might have been imagined.
Rossi
Ana M
AM
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK. cwt1000@cam.ac.uk
Taylor
Colin W
CW
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D002147:Calmodulin / Q000378:metabolism*; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*
D015220:Calcium Channels; D002147:Calmodulin; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium