title: Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.
abstract: Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.
authors.affiliation: Metabolic Disease Research, Abbott Laboratories, Dept 4CB, Building AP-10, Rm. L-14, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA.
authors.forename: Noah
authors.initials: N
authors.lastname: Tu
authors.forename: J T
authors.initials: JT
authors.lastname: Link
authors.forename: Bryan K
authors.initials: BK
authors.lastname: Sorensen
authors.forename: Maurice
authors.initials: M
authors.lastname: Emery
authors.forename: Marlena
authors.initials: M
authors.lastname: Grynfarb
authors.forename: Annika
authors.initials: A
authors.lastname: Goos-Nilsson
authors.forename: Bach
authors.initials: B
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry* / Q000493:pharmacokinetics; D001682:Biological Availability; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000187:drug effects*
chemical_list: D001647:Bile Acids and Salts; D011965:Receptors, Glucocorticoid