title: Rapid improvement of acute pulmonary edema with angiotensin converting enzyme inhibitor under hemodialysis in a patient with renovascular disease.
abstract: A 71-year-old man with bilateral renovascular disease was admitted to Hamamatsu University hospital because of appetite loss and acute shortness of breath due to acute pulmonary edema (APE) with accelerated hypertension and renal failure. Hypertension and APE were controlled by an angiotensin converting enzyme inhibitor (ACEI) and four sessions of hemodialysis with reduction of 1.8 kg bodyweight. Renal function was later stabilized and the patient required no ACEI or hemodialysis. A trial of right renal angioplasty 1 month after admission failed and renal function deteriorated (serum creatinine 7.1 mg/dL) with accelerated hypertension, gain of bodyweight and APE. Even after four sessions of hemodialysis with adequate reduction of bodyweight, APE was not controlled, but it rapidly improved after administration of an ACEI, without major bodyweight change. As no apparent cardiac dysfunction was evident, APE might have been caused by a direct action of angiotensin II on hyperpermeability in pulmonary capillaries. Blocking of angiotensin II should be considered in such patients even after introduction of hemodialysis.
authors.affiliation: First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. yf0516@hama-med.ac.jp
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujigaki
authors.forename: Akashi
authors.initials: A
authors.lastname: Togawa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Miyaji
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Naro
authors.initials: N
authors.lastname: Ohashi
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Fukasawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Yasuda
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Hishida
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yonemura
mesh_terms: D000208:Acute Disease; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006978:Hypertension, Renovascular / Q000150:complications; D008168:Lung / Q000098:blood supply; D008297:Male; D011654:Pulmonary Edema / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors