Antiulcerogenic effects of Campomanesia xanthocarpa.
Campomanesia xanthocarpa O. Berg., popularly known as "gabiroba", is used in Brazilian folk medicine for ulcer treatment. The hydroalcoholic extract of Campomanesia xanthocarpa leaves was evaluated for antiulcerogenic activity, acute toxicity and phytochemical profile. Oral administration of the extract at 400 mg/kg proved to be effective in preventing gastric ulceration in rats and did not produce toxic symptoms in mice in doses up to 5 g/kg. TLC screening methods revealed the presence of flavonoids, saponins and tannins.
Markman
Blanca Elena Ortega
BE
Instituto Adolfo Lutz, São Paulo, Brazil.
Bacchi
Elfriede Marianne
EM
Kato
Edna Tomiko Myiake
ET
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D001938:Brazil; D002855:Chromatography, Thin Layer; D005260:Female; D008297:Male; D051379:Mice; D027822:Myrtaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000517:prevention & control*; D023382:Toxicity Tests, Acute
D000897:Anti-Ulcer Agents; D010936:Plant Extracts