Proteomics and chronic inflammatory bowel diseases.
Inflammatory bowel diseases (IBD) are relatively frequent in developed countries. Physiopathological events involved in the etiology of IBDs include activation of immune, mesenchymal and epithelial cells. This review gives an overview of the currently applied proteomics technologies. It describes metabolic changes and goes into the approaches using this methodology to understand the molecular mechanisms implicated in the development of the disease.
Felley-Bosco
Emanuela
E
Institute of Pharmacology and Toxicology, Rue du Bugnon 27, Lausanne 1005, Switzerland. emanuela.felley-bosco@ipharm.unil.ch
André
Muriel
M
D015180:Electrophoresis, Gel, Two-Dimensional; D015870:Gene Expression; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics
D011506:Proteins