An acute toxic neuropathy caused by organo-phosphate poisoning in hens.
OBJECTIVE
Organophosphorus compounds can induce an acute toxic peripheral neuropathy. In hens, the acute peripheral neuropathy was induced by poisoning with organo-phosphorus compound (OPC)--tri-ortho-cresyl phosphate (TOCP).


METHODS
In the course of an acute TOCP-induced toxic neuropathy in hens the activity of following enzymes was analysed: asparaginase, glutaminase, glutamat-dehydrogenase, AMP and adenosine deaminases and 5'nucleotidase; ALT (SGPT), AST (SGOT) and proteins levels were estimated.


RESULTS
A decrease in activity of all analysed enzymes was observed; the amount of proteins was increased.


CONCLUSIONS
The biochemical changes display the slowing or stoppage in axonal transport of proteins. The disturbance of axoplasmic flow and the axonal demyelination may be considered as an attribute of peripheral neuropathy. (Tab. 1, Fig. 1, Ref. 32.).
Varsik
P
P
1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia. neurologia@faneba.sk
Pechan
I
I
Buranova
D
D
Kucera
P
P
D000208:Acute Disease; D000818:Animals; D002645:Chickens; D005260:Female; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000201:enzymology* / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D014317:Tritolyl Phosphates / Q000506:poisoning*
D014317:Tritolyl Phosphates; C025541:tri-o-cresyl phosphate