title: Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense.
abstract: Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N-feruloyloctopamine (2), trans-N -caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 microg ml(-1) and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 microg ml(-1). All four compounds impeded the dimorphic transition of pathogen, Candida albicans.
authors.affiliation: Department of Microbiology, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Dong Gun
authors.initials: DG
authors.lastname: Lee
authors.forename: Yoonkyung
authors.initials: Y
authors.lastname: Park
authors.forename: Mi-Ran
authors.initials: MR
authors.lastname: Kim
authors.forename: Hyun Jun
authors.initials: HJ
authors.lastname: Jung
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Seu
authors.forename: Kyung-Soo
authors.initials: KS
authors.lastname: Hahm
authors.forename: Eun-Rhan
authors.initials: ER
authors.lastname: Woo
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001709:Biotechnology; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000378:metabolism; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis; D006801:Humans; D032305:Lycium / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009655:Octopamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D024301:Plant Bark / Q000378:metabolism*; D010936:Plant Extracts; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D014250:Trichosporon / Q000378:metabolism; D014439:Tyramine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D000935:Antifungal Agents; D002109:Caffeic Acids; D003373:Coumaric Acids; C498173:N-feruloyloctopamine; D010936:Plant Extracts; C472079:dihydro-N-caffeoyltyramine; D009655:Octopamine; C481438:N-caffeoyltyramine; D014439:Tyramine