title: Human demineralised bone matrix as a bone substitute for reconstruction of cystic defects of the lower jaw.
abstract: In a retrospective study validated by a standardized clinical and radiological examination, the bone regeneration in 90 patients with cystic mandibular defects was examined. In 50 patients bony defect reconstructions with human demineralised bone matrix (HDBM) were carried out, while in a comparable group of 40 patients the hollow pockets were left to regenerate bone spontaneously. The bone regeneration after the implantation of human demineralised bone matrix (HDBM) was subjected to a comparative validation. Osteoinductive proteins present in HDBM (bone morphogenetic proteins) can diffuse into the implant seat and induce new bone formation (osteoinduction). A markedly faster and more thorough bone regeneration was demonstrated after the surgical therapy of cystic mandibular lesions with HDBM than without. HDBM also proved to be exceptionally biocompatible.
authors.affiliation: University Hospital Charité, Campus Virchow-Klinikum, Medical Faculty of the Humboldt University of Berlin, Department of Oral and Maxillofacial Surgery/Plastic Surgery, Uhlandstrasse 111, Berlin, D-10717, Germany(IvettaKuhls@web.de)
authors.forename: R
authors.initials: R
authors.lastname: Kuhls
authors.forename: M
authors.initials: M
authors.lastname: Werner-Rustner
authors.forename: I
authors.initials: I
authors.lastname: Küchler
authors.forename: F
authors.initials: F
authors.lastname: Soost