title: [Validation of the Diagnostic Interview for Genetic Studies (DIGS) in Colombia].
abstract: An interview tool, Diagnostic Interview for Genetic Studies (DIGS 3.0), was translated into Spanish for application in studies of psychiatric disorders in Colombia. Two Spanish translations of the original English version of DIGS were prepared and back-translated into English. A review committee verified the linguistic and cultural equivalence of the translations. The evaluator and test-retest reliability were assessed calculating Cohen's kappa for samples of 65 and 91 patients respectively. DIGS proved valid in both appearance and content. The confidence interval (C.I.) was excellent for schizophrenia (kappa = 0.81, C.I. 95% = 0.68-0.93), bipolar disorder (kappa = 0.87, C.I. 95% = 0.75-0.99), major depressive disorder (kappa = 0.86, C.I. 95% = 0.70-1.00), and for a normal diagnosis (kappa = 0.65, C.I. 95% = 0.41-0.89); it was good for other psychiatric diagnosis (kappa = 0.65, C.I. 95% = 0.41-0.89) and poor for schizoaffective disorder (kappa = 0.37, C.I. 95% = -0.02-0.76). Test-retest reliability was excellent for all diagnoses (kappa > 0.8), except for "other psychiatric diagnoses" (kappa = 0.64, C.I. 95% = 0.31-0.96). The Spanish translation of the DIGS was comprehensible, with face and content validity, and good test-retest and evaluator reliability. This translation will be a useful tool for genetic studies of psychiatric disorders in Latin America, particularly where schizophrenia and affective disorders are involved.
authors.affiliation: Programa de Investigación en Psiquiatría Genética, Departamento de Psiquiatría y Laboratorio de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Palacio
authors.forename: Jenny
authors.initials: J
authors.lastname: García
authors.forename: María Patricia
authors.initials: MP
authors.lastname: Arbeláez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sánchez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Aguirre
authors.forename: Isabel Cristina
authors.initials: IC
authors.lastname: Garcés
authors.forename: Gabriel Jaime
authors.initials: GJ
authors.lastname: Montoya
authors.forename: Juliana
authors.initials: J
authors.lastname: Gómez
authors.forename: Angela
authors.initials: A
authors.lastname: Agudelo
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: López
authors.forename: Jorge Julián
authors.initials: JJ
authors.lastname: Calle
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Cardeño
authors.forename: Juan Fernando
authors.initials: JF
authors.lastname: Cano
authors.forename: María Cecilia
authors.initials: MC
authors.lastname: López
authors.forename: Patricia
authors.initials: P
authors.lastname: Montoya
authors.forename: Claudia Patricia
authors.initials: CP
authors.lastname: Herrera
authors.forename: Natalia
authors.initials: N
authors.lastname: González
authors.forename: Alejandro
authors.initials: A
authors.lastname: González
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bedoya
authors.forename: Andrés
authors.initials: A
authors.lastname: Ruiz
authors.forename: Jorge
authors.initials: J
authors.lastname: Ospina
mesh_terms: D003105:Colombia; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D007802:Language; D001523:Mental Disorders / Q000175:diagnosis* / Q000235:genetics; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D015203:Reproducibility of Results; D014175:Translating