title: Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection.
abstract: Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection and were correlated with HSV load. It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection.
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kawada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ando
authors.forename: Naoko
authors.initials: N
authors.lastname: Tanaka-Kitajima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nunoi
authors.forename: Fumio
authors.initials: F
authors.lastname: Endo
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Morishima
mesh_terms: D017209:Apoptosis; D000068800:Etanercept; D006561:Herpes Simplex / Q000276:immunology* / Q000401:mortality / Q000503:physiopathology* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000276:immunology / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D015850:Interleukin-6 / Q000097:blood; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D018139:Simplexvirus / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D019562:Viral Load
chemical_list: D007074:Immunoglobulin G; D015850:Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D000068800:Etanercept