Chronic administration of caffeine: effect on the activities of hepatic antioxidant enzymes of Ehrlich ascites tumor-bearing mice.
Chronic ingestion (for 22-30 consecutive days) of caffeine (20 mg/kg/day, p.o.) increased the activities of the hepatic enzymes- catalase (CAT) and superoxide dismutase (SOD) and decreased its lipid peroxidation (LP) in mice. Development of Ehrlich ascites carcinoma (EAC) cell decreased the activities of hepatic CAT and SOD and increased LP. But pretreatment of caffeine for 12 consecutive days and continuation of its treatment during the course of development of EAC cells restored the EAC cell-induced changes in liver CAT, SOD and LP to their corresponding control values. Thus, the present results by confirming the results of others previously published, suggest that caffeine is an antioxidant and may act as an anticarcinogen.
Mukhopadhyay
Sutapa
S
Department of Biochemistry, University College of Science, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 700 019, India.
Mondal
Anup
A
Poddar
Mrinal K
MK
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology* / Q000473:pathology; D002374:Catalase / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D013482:Superoxide Dismutase / Q000378:metabolism*
D000975:Antioxidants; D000697:Central Nervous System Stimulants; D016166:Free Radical Scavengers; D002110:Caffeine; D002374:Catalase; D013482:Superoxide Dismutase