Synthesis of novel substituted tetrazoles having antifungal activity.
In an effort to find potent antifungal agents, a variety of triazole derivatives with a 5-substituted tetrazole structure 6, 7, 12 and 14 were prepared and evaluated for antifungal activity against Candida spp., Cryptococcus neoformans, and Aspergillus spp. in vitro. The location of the methyl group at the C-3 of compounds 12 and 14 has been demonstrated to be a key structural element of antifungal potency.
Upadhayaya
Ram Shankar
RS
Medicinal Chemistry Division, New Chemical Entity Research, Lupin Research Park, 46/47 A, At Village Nande, Taluka Mulshi, Pune 411 042, Maharashtra, India.
Jain
Sanjay
S
Sinha
Neelima
N
Kishore
Nawal
N
Chandra
Ramesh
R
Arora
Sudershan K
SK
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D013777:Tetrazoles