Mechanisms of obesity-related hypertension.
Obesity has become an epidemic problem in western societies, contributing to metabolic diseases, hypertension and cardiovascular disease. Although the importance of obesity as a cause of hypertension is well established, the molecular basis of the relationship between obesity and increased blood pressure remains poorly understood. This brief review examines the association between obesity and hypertension along with the mechanisms proposed to explain this association, while presenting evidence of a direct causal effect of adipose tissue in the development of hypertension through the involvement of the adrenal cortex.
Lamounier-Zepter
V
V
Department of Endocrinology, University Medical Center, Heinrich Heine University, Düsseldorf, Germany. Valeria.Lamounier-Zepter@uni-duesseldorf.de
Bornstein
S R
SR
Ehrhart-Bornstein
M
M
D000273:Adipose Tissue / Q000503:physiopathology*; D000311:Adrenal Glands / Q000503:physiopathology*; D000450:Aldosterone / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007031:Hypothalamus / Q000503:physiopathology*; D008099:Liver / Q000503:physiopathology; D008901:Mineralocorticoids / Q000502:physiology; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D005227:Fatty Acids; D008901:Mineralocorticoids; D000450:Aldosterone