title: Expanded use of transplantation techniques: abdominal wall transplantation and intestinal autotransplantation.
abstract: Surgical principles and techniques derived from organ transplantation surgery can provide novel applications in general surgery. We present an update on our 5-year experience with intestinal autotransplantation and abdominal wall transplantation. Nine patients underwent intestinal or multivisceral transplantation with the addition of 10 abdominal wall grafts to cover the large open areas from previous surgeries. Seven patients underwent near-total abdominal evisceration, ex vivo resection of masses at the base of the mesentery, followed by intestinal autotransplantation; 44% of the abdominal wall graft recipients are alive, but none of the fatalities were related to the graft itself. In two cases the graft had to be removed due to venous thrombosis. Of patients with intestinal autotransplants, 71% are alive with two mortalities due to recurrent metastatic malignancy. In only one case, the intestinal autograft had to be removed because of venous thrombosis. All surviving patients but one are on a regular diet; two are on supplemental enteral feeds. These results show that anastomotic and resection techniques derived from the experience in solid organ transplant can be utilized in complex wound closure, as is the case of abdominal wall transplantation, or resection of large retroperitoneal tumors with intestinal autotransplantation.
authors.affiliation: Division of Liver and GI Transplantation, University of Miami, Miami, Florida, USA.
authors.forename: G
authors.initials: G
authors.lastname: Selvaggi
authors.forename: D M
authors.initials: DM
authors.lastname: Levi
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: J
authors.initials: J
authors.lastname: Madariaga
authors.forename: J
authors.initials: J
authors.lastname: Moon
authors.forename: S
authors.initials: S
authors.lastname: Nishida
authors.forename: A G
authors.initials: AG
authors.lastname: Tzakis
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002779:Cholestasis / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007422:Intestines / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011169:Portal Vein / Q000601:surgery; D012189:Retrospective Studies; D012778:Short Bowel Syndrome / Q000601:surgery; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000601:surgery