title: Correlation of neuron-specific enolase and S100B with histological cerebral damage in fetal sheep after severe asphyxia.
abstract: Experimental brain damage was induced in 16 fetal sheep by umbilical cord occlusion, and the correlation of neuron-specific enolase (NSE) or S100B with the damage grade was investigated in seven fetuses. Significant correlations of damage degree with NSE (p = 0.016) and S100B (p = 0.018) in serum 2 h after insult were shown by Spearman's test. These findings suggest that they represent potentially useful markers for detecting brain damage at early stage after ischemic insult.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Japan. fujii-e@ncchd.go.jp
authors.forename: Eriko Y
authors.initials: EY
authors.lastname: Fujii
authors.forename: Masatomo
authors.initials: M
authors.lastname: Kozuki
authors.forename: Junwu
authors.initials: J
authors.lastname: Mu
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ino
authors.forename: Norichika
authors.initials: N
authors.lastname: Ushioda
authors.forename: Takuya
authors.initials: T
authors.lastname: Tomimatsu
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Fukuda
authors.forename: Toru
authors.initials: T
authors.lastname: Kanzaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakayama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murata
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D001921:Brain / Q000196:embryology / Q000378:metabolism* / Q000473:pathology; D003251:Constriction, Pathologic; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000502:physiology; D005311:Fetal Hypoxia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D005333:Fetus; D002534:Hypoxia, Brain / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D015588:Observer Variation; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D015203:Reproducibility of Results; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism*; D012756:Sheep; D014470:Umbilical Cord / Q000503:physiopathology; D015854:Up-Regulation / Q000502:physiology
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase