A comparative prospective study of two available solutions for kidney and liver preservation.
BACKGROUND
Viaspan (University of Wisconsin [UW]) solution is the gold standard for abdominal organ preservation. Celsior (CEL) is an extracellular-type, low-potassium, low-viscosity solution, initially used for heart and lung preservation. We have performed a prospective multicenter study to compare the role of these cold-storage solutions on kidney and liver recovery after transplantation.


METHODS
From March 15, 2000 to December 31, 2001, 441 (172 CEL and 269 UW) renal transplants (RT) and 175 (79 CEL and 96 UW) liver transplants (LT) were included in the study.


RESULTS
Perfusate volume used was significantly lower in the UW group, being 4,732 +/- 796 mL versus 5,826 + 834 mL in the CEL group (P < 0.001). In LT, median total bilirubin serum levels were significantly higher at 5 and 7 posttransplant days in the UW group (90.6 and 92.3 micromol/L, respectively) as compared with CEL (51.3 and 63.4 micromol/L, respectively). After LT, primary nonfunction (PNF) rates in the CEL and UW groups were 3.8% and 4.2% (P = NS) respectively, with 1-year graft and patient survival being 83.3% versus 85.4% (P = NS) and 89.9% versus 90.6% (P = NS). After RT, delayed graft function (DGF) rates were 23.2% and 22.7% (P = NS), respectively; PNF rates were 1.9% and 1.7% (P = NS) respectively, with 1-year graft and patient survival being 92.3% versus 94.2% (P = NS) and 99.4% versus 97.7% (P = NS).


CONCLUSIONS
CEL solution was shown to be as effective as UW in both liver and kidney preservation. In LT patients, biliary function recovery is significantly better in the CEL group. CEL solution represents an efficacious option in multiorgan harvesting.
Pedotti
Paola
P
Genetic and Molecular Epidemiology Unit-IRCCS Ospedale Maggiore, Milano, Italy.
Cardillo
Massimo
M
Rigotti
Paolo
P
Gerunda
Giorgio
G
Merenda
Roberto
R
Cillo
Umberto
U
Zanus
Giacomo
G
Baccarani
Umberto
U
Berardinelli
Maria Luisa
ML
Boschiero
Luigi
L
Caccamo
Lucio
L
Calconi
Gilberto
G
Chiaramonte
Stefano
S
Dal Canton
Antonio
A
De Carlis
Luciano
L
Di Carlo
Valerio
V
Donati
Donato
D
Montanaro
Domenico
D
Pulvirenti
Andrea
A
Remuzzi
Giuseppe
G
Sandrini
Silvio
S
Valente
Umberto
U
Scalamogna
Mario
M
D000241:Adenosine; D000328:Adult; D000493:Allopurinol; D001663:Bilirubin / Q000097:blood; D015331:Cohort Studies; D015925:Cryopreservation; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D005978:Glutathione; D006085:Graft Survival; D006639:Histidine; D006801:Humans; D007328:Insulin; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation; D008099:Liver / Q000503:physiopathology; D016031:Liver Transplantation; D008353:Mannitol; D008875:Middle Aged; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011446:Prospective Studies; D011887:Raffinose; D016019:Survival Analysis
C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose; D001663:Bilirubin