Small RNAs shed some light.
Small regulatory RNAs can act by pairing with their target messages, targeting themselves and the mRNA for degradation; Lenz et al. (this issue of Cell) now report that multiple small RNAs are essential regulators of the quorum-sensing systems of Vibrio species, including the regulation of virulence in V. cholerae.
Gottesman
Susan
S
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D017930:Genes, Reporter; D008163:Luminescent Measurements; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010766:Phosphorylation; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism; D014733:Vibrio / Q000235:genetics / Q000502:physiology*; D014734:Vibrio cholerae / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D014774:Virulence
D035683:MicroRNAs; D015534:Trans-Activators