Synthesis of pyrido[2,1-c][1,2,4]triazine,1,2,4 triazolo[4,3-a] pyridine and 2-(substituted-pyrazolyl)nicotinonitrile and their effect on Biomphalaria alexandrina snail enzymes.
The reaction of 2-hydrazino-4-(4-methoxyphenyl)-6-pheny-nicotinonitrile 3 with halo compounds yielded 4a-c,5,6. Heating 3 with carbon disulphide gave 7-(4-methoxyphenyl)-5-phenyl-3-thioxo-2,3-dihydro [1,2,4-] triazolo [4,3-a] pyridine-8-carboxylic amide 7. The behaviour of 3 towards some alpha,beta-unsaturated nitriles ,ethoxymethylene and ketene dithioacetal derivatives has been investigated, affording 9a-c,11a-c,13a-c,16a,b respectively. The activity of compounds 4a,5,6 and 7 have been investigated as molluscicidal.
Zaki
M E A
ME
Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt.
Fathalla
O A
OA
Swelam
S A
SA
Aly
H F
HF
D000818:Animals; D001700:Biomphalaria / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000633:toxicity*; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008975:Molluscacides / Q000138:chemical synthesis* / Q000633:toxicity*; D009538:Nicotine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000633:toxicity*; D011725:Pyridines / Q000138:chemical synthesis* / Q000633:toxicity*; D013055:Spectrophotometry, Infrared; D014227:Triazines / Q000138:chemical synthesis* / Q000633:toxicity*; D014230:Triazoles / Q000138:chemical synthesis* / Q000633:toxicity*
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D008975:Molluscacides; D011725:Pyridines; D014227:Triazines; D014230:Triazoles; C489331:pyrido(2,1-c)(1,2,4)triazine,1,2,4 triazolo(4,3-a) pyridine; D009538:Nicotine