title: Scleroderma and the taxanes. Is there really a link?
abstract: Scleroderma has been associated with exposure to many substances in the past ranging from vinyl chloride to silicon dioxide. In recent years there have been a number of case reports linking modern chemotherapy agents, such as the taxanes to the development of scleroderma like changes. We present a further case of scleroderma in association with chemotherapy but question the role of some of the agents previously implicated. A brief review of the current literature is included.
authors.affiliation: Department of Dermatology, St George's Hospital, The Royal Marsden Hospital, London, UK. drpaulfarrant@doctors.org.uk
authors.forename: P B J
authors.initials: PB
authors.lastname: Farrant
authors.forename: P S
authors.initials: PS
authors.lastname: Mortimer
authors.forename: M
authors.initials: M
authors.lastname: Gore
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel