Analytical study of the effect of recombination on evolution via DNA shuffling.
DNA shuffling is an evolutionary protocol wherein cycles of selection, recombination, mutation, and amplification are employed to evolve proteins and DNA sequences. Experiments have shown its superiority to traditional protocols which do not employ recombination. Motivated by DNA shuffling, we investigate a multilocus evolutionary model that incorporates selection, recombination, and point mutations. Due to simplicity of the model, for the case of an infinite population we can obtain a full analytical treatment of both its dynamical and equilibrium properties, and study the benefit of recombination explicitly and quantitatively. We also briefly discuss finite-population size corrections.
Peng
Weiqun
W
Center for Theoretical Biological Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Levine
Herbert
H
Hwa
Terence
T
Kessler
David A
DA
D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D019143:Evolution, Molecular; D015233:Models, Statistical; D009154:Mutation; D010641:Phenotype; D017354:Point Mutation; D011995:Recombination, Genetic; D013997:Time Factors
D004247:DNA