title: Regio- and stereospecific syntheses of syn- and anti-1,2-imidazolylpropylamines from the reaction of 1,1'-carbonyldiimidazole with syn- and anti-1,2-amino alcohols.
abstract: The regio- and stereospecific conversion of syn- and anti-1,2-amino alcohols to their respective syn- and anti-1,2-imidazolylpropylamines via treatment with 1,1'-carbonyldiimidazole is described. The rationale behind the regio- and stereospecific nature as well as the generality of the reaction is discussed.
authors.affiliation: OSI Pharmaceuticals, Inc., Broadhollow Bioscience Park, 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. mark.mulvihill@osip.com
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mulvihill
authors.forename: Cara
authors.initials: C
authors.lastname: Cesario
authors.forename: Vanessa
authors.initials: V
authors.lastname: Smith
authors.forename: Patricia
authors.initials: P
authors.lastname: Beck
authors.forename: Anthony
authors.initials: A
authors.lastname: Nigro
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D006632:Histamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D007093:Imidazoles; C047962:imidazolyl-4-propylamine; C006900:N,N-carbonyldiimidazole; D006632:Histamine