[Paroxysmal nocturnal hemoglobinuria revealed by hepatic vein thrombosis (Budd-Chiari syndrome) during Infliximab therapy].
We report the case of a 41-Year-old man presenting with hepatic vein thrombosis (Budd-Chiari syndrome) during Infliximab therapy for ankylosing spondylitis. The systematic work-up revealed paroxysmal nocturnal hemoglobinuria. One Year later the patient was receiving anticoagulation therapy and was in good condition. The role of Infliximab in the development of thrombosis in this patient with rare underlying thrombophilia is discussed.
Sobkeng Goufack
Enam
E
Service d'Hépatogastroentérologie, Hôpital Trousseau, CHRU de Tours, 37044 Tours Cedex.
Mammou
Saloua
S
Scotto
Béatrice
B
De Muret
Anne
A
Maakaroun
Abdallah
A
Socie
Gérard
G
Bacq
Yannick
Y
D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D006502:Budd-Chiari Syndrome / Q000139:chemically induced* / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D006457:Hemoglobinuria, Paroxysmal / Q000209:etiology*; D006801:Humans; D000069285:Infliximab; D008297:Male; D013167:Spondylitis, Ankylosing / Q000188:drug therapy
D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab