title: New World cutaneous leishmaniasis in returned travellers: treatment failures using intravenous sodium stibogluconate.
abstract: Treatment outcome was determined among a cohort of travellers who returned to the UK between February 2000 and February 2001 with New World cutaneous leishmaniasis caused by species of the Leishmania (Viannia) subgenus. Among 18 patients who completed treatment with 20 mg/kg/d of i.v. sodium stibogluconate (NaSb) for 20 d, early relapse of disease occurred in 2 patients with regional dissemination in 1 and mucocutaneous involvement in the other. Drug susceptibility testing in vitro of the clinical isolate from 1 of these patients confirmed tolerance to high concentrations of NaSb.
authors.affiliation: Hospital for Tropical Diseases, Mortimer Market Centre, Capper Street, London WC1E 6AU, UK. stevelawn@yahoo.co.uk
authors.forename: S D
authors.initials: SD
authors.lastname: Lawn
authors.forename: V
authors.initials: V
authors.lastname: Yardley
authors.forename: F
authors.initials: F
authors.lastname: Vega-Lopez
authors.forename: J
authors.initials: J
authors.lastname: Watson
authors.forename: D N
authors.initials: DN
authors.lastname: Lockwood
mesh_terms: D000328:Adult; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008297:Male; D021261:Parasitic Sensitivity Tests; D012189:Retrospective Studies; D014195:Travel; D017211:Treatment Failure
chemical_list: D000981:Antiprotozoal Agents; D000967:Antimony Sodium Gluconate