title: Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia.
abstract: Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD). These dyslipidemias share many phenotypic features, suggesting a partially overlapping molecular pathogenesis. This was supported by our previous pooled data analysis of the genome scans for low HDL-C and FCHL, which identified three shared chromosomal regions for a qualitative HDL-C trait on 8q23.1, 16q23.3, and 20q13.32. This study further investigates these regions as well as two other loci we identified earlier for premature CHD on 2q31 and Xq24 and a locus for high serum triglycerides (TGs) on 10q11. We analyzed 67 microsatellite markers in an extended study sample of 1,109 individuals from 92 low HDL-C or FCHL families using both qualitative and quantitative lipid phenotypes. These analyses provided evidence for linkage (a logarithm of odds score of 3.2) on 10q11 using a quantitative HDL-C trait. Importantly, this region, previously linked to TGs, body mass index, and obesity, provided evidence for association for quantitative TGs (P = 0.0006) and for a combined trait of HDL-C and TGs (P = 0.008) with marker D10S546. Suggestive evidence for linkage also emerged for HDL-C on 2q31 and for TGs on 20q13.32. Finnish families ascertained for dyslipidemias thus suggest that 10q11, 2q31, and 20q13.32 harbor loci for HDL-C and TGs.
authors.affiliation: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland.
authors.forename: Heidi E
authors.initials: HE
authors.lastname: Lilja
authors.forename: Elina
authors.initials: E
authors.lastname: Suviolahti
authors.forename: Aino
authors.initials: A
authors.lastname: Soro-Paavonen
authors.forename: Tero
authors.initials: T
authors.lastname: Hiekkalinna
authors.forename: Aaron
authors.initials: A
authors.lastname: Day
authors.forename: Kenneth
authors.initials: K
authors.lastname: Lange
authors.forename: Eric
authors.initials: E
authors.lastname: Sobel
authors.forename: Marja-Riitta
authors.initials: MR
authors.lastname: Taskinen
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
authors.forename: Markus
authors.initials: M
authors.lastname: Perola
authors.forename: Päivi
authors.initials: P
authors.lastname: Pajukanta
mesh_terms: D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000235:genetics*; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D002889:Chromosomes, Human, Pair 2; D002890:Chromosomes, Human, Pair 20; D005192:Family Health; D005387:Finland / Q000453:epidemiology; D008040:Genetic Linkage; D006801:Humans; D006949:Hyperlipidemias / Q000145:classification / Q000209:etiology / Q000235:genetics*; D018895:Microsatellite Repeats; D008875:Middle Aged; D017720:Molecular Epidemiology
chemical_list: D008076:Cholesterol, HDL