Stem cell research: its relevance to reproductive biology.
Stem cells provide an excellent model system to understand the differentiation, development and functioning of gonads, and further use of these cells in transplantation or cell-based therapies. Embryonic germ cells present as a better source of pluripotent stem cells. The germ cells are specialized cells, which differentiate into sperm or oocytes. Spermatogonial stem cells are the only stem cells in the adult mammalian body that can be recognized and studied at cellular level with respect to proliferation and differentiation. In the present study, basic process of spermatogenesis, testicular niche and molecular regulation of spermatogenesis and density regulation has been discussed. Research on oogonial stem cells has recently been encouraged due to the demand for oocytes for various research purposes. Mechanism of regulation of follicle formation, oocyte attrition and follicle development and atresia are only partially understood. Hence, the stages of development, its interaction with the neighbouring somatic cells during each developmental stage and the molecular regulation underlying it has been reviewed. These studies will result in establishment of treatment of ovarian disorders, and in identifying cure for infertility that occurs due to ovarian pathophysiology. Indian scenario in terms of stem cell research and its benefits is also discussed.
Nandedkar
Tarala
T
National Institute for Research in Reproductive Health, (ICMR), Jehangir Merwanji Street, Parel, Mumbai 400 012, India. cellbioirr@hotmail.com
Narkar
Madhura
M
D000818:Animals; D035843:Biomedical Research; D005260:Female; D006801:Humans; D008297:Male; D012098:Reproduction / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*