Biotransformation of 3alpha,4alpha-dihydroxy-dihydro-beta-agarofuran by Rhizopus nigricans.
3alpha,4alpha-Dihydroxy-dihydro-beta-agarofuran (1), prepared from (+)-dihydrocarvone by a traditional synthetic method, the Robinson annelation, was biotransformed by R. nigricans to afford a new metabolite characterized as 1alpha,3alpha,4alpha-trihydroxy-dihydro-beta-agarofuran (2) by spectroscopic method. An acetylated derivative was prepared.
Alarcón
Julio
J
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad del Bío-Bío, Chillán Chile. jalarcon@pehuen.chillan.ubiobio.cl
Aguila
Sergio
S
D001711:Biotransformation; D029753:Celastraceae / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D012233:Rhizopus / Q000378:metabolism*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000378:metabolism*
C489951:3,4-dihydroxydihydro-beta-agarofuran; D012717:Sesquiterpenes