Synthesis of chiral 13C,77Se-labeled selones.
Stable isotope-labeled N-acyl selones have been constructed in fewer than four steps from readily available starting materials. Site-specific labeling was achieved using the following synthons: bromo[2-(13)C]acetic acid, [(13)C]formic acid, and elemental (77)Se. These labeled selones have been found to provide unique insights into enolate structure and may be useful in the detection and quantitation of remotely disposed chiral centers in compounds in short supply.
Ollivault-Shiflett
Morgane
M
Los Alamos National Laboratory, Bioscience Division, the Biotechnology, Spectroscopy, and Isotope Chemistry group (B-SIC), NIH National Stable Isotope Resource, MS E529, Los Alamos, NM 87545, USA. pete-silks@lanl.gov
Kimball
David B
DB
Silks
L A Pete
LA
D002247:Carbon Isotopes; D007554:Isotopes; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018036:Selenium Compounds / Q000737:chemistry*
D002247:Carbon Isotopes; D007554:Isotopes; D018036:Selenium Compounds