title: Is there a relation between duration of cyclosporine usage and right and left ventricular function in renal transplant patients? Tissue Doppler Echocardiography study.
abstract: BACKGROUND
  Our aim was to investigate the effect of cyclosporine (CsA), which is commonly used in renal transplant patients and causes myocardial fibrosis and elevated arterial tension, on cardiac function.
  
  
  METHODS
  Sixty-six renal transplant patients (RTPs) and 25 healthy controls were included in the study. Renal transplantation patients were divided according to time of CsA exposure: group 1 (0 to 36 months); group 2 (36 to 72 months) and group 3 (> 72 months). Systolic peak velocity (Sm, mitral; St, tricuspid) and mitral early (e)/late (a) (Me/a) and tricuspid e/a (Te/a) waves of the right and the left ventricles were measured by pulse-wave (PW) Doppler used for tissue Doppler imaging of both ventricles as well as the ventricle free wall near to the lateral tricuspid and the posterior mitral leaflets. The measurements included conventional diastolic early (E) and late (A) waves and deceleration time (DT) of the E wave, isovolumetric relaxation time (IVRT) of both ventricles, as well as left ventricular systolic ejection fraction (EF).
  
  
  RESULTS
  There were no statistically significant differences between the groups with regard to demographic, clinical, and most biochemical characteristics. Left ventricular EF was normal in all groups; there were no statistically significant differences. IVRT and DT of left ventricle and right ventricle DT values were similar among RTPs. On the other hand, values were found to be increased in RTP groups compared with the control group. E/A ratio, Me/a Te/a of both ventricles were similar among RTPs. However, these values were found to be decreased in RTP groups compared with the control group.
  
  
  CONCLUSIONS
  Although left ventricular systolic functions were normal in all groups, there were statistically significant impairments of biventricular diastolic function parameters among renal transplant recipients compared with the control group.
authors.affiliation: Department of Cardiology, Capa, Istanbul.
authors.forename: H
authors.initials: H
authors.lastname: Oflaz
authors.forename: A
authors.initials: A
authors.lastname: Turkmen
authors.forename: O
authors.initials: O
authors.lastname: Kocaman
authors.forename: D
authors.initials: D
authors.lastname: Erdogan
authors.forename: M
authors.initials: M
authors.lastname: Meric
authors.forename: A
authors.initials: A
authors.lastname: Oncul
authors.forename: N
authors.initials: N
authors.lastname: Koylan
authors.forename: E
authors.initials: E
authors.lastname: Yilmaz
authors.forename: C
authors.initials: C
authors.lastname: Yilmaz
authors.forename: F
authors.initials: F
authors.lastname: Selcukbiricik
authors.forename: E
authors.initials: E
authors.lastname: Kasikcioglu
authors.forename: M S
authors.initials: MS
authors.lastname: Sever
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use*; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D008297:Male; D012016:Reference Values; D013997:Time Factors; D014511:Uremia / Q000000981:diagnostic imaging; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D002784:Cholesterol