Chromosomal translocations and non-B DNA structures in the human genome.
The mechanisms of chromosomal translocations in mammalian cells have been largely undefined. Recent progress on the most common translocation in human cancer, t(14;18), highlights interesting issues in DNA structure and in the enzymes involved in the cutting and joining phases of the process.
Raghavan
Sathees C
SC
Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA.
Lieber
Michael R
MR
D000818:Animals; D004247:DNA / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D009690:Nucleic Acid Conformation; D014178:Translocation, Genetic / Q000235:genetics*
D004273:DNA, Neoplasm; D004247:DNA