Repeated stress-induced stimulation of catecholamine response is not followed by altered immune cell redistribution.
Stress response is considered an important factor in the modulation of immune function. Neuroendocrine hormones, including catecholamines, affect the process of immune cell redistribution, important for cell-mediated immunity. This longitudinal investigation was aimed at evaluating the effect of repeated stress-induced elevation of catecholamines on immune cell redistribution and expression of adhesive molecules. We assessed the responses of epinephrine (EPI), norepinephrine (NE), cortisol, changes in lymphocytes subpopulations, and percentages of CD11a+, CD11b+, and CD62L+ lymphocytes to a 20-min treadmill exercise of an intensity equal to 80% of the individual's Vo(2)max. The exercise was performed before and after 6 weeks of endurance training consisting of a 1-h run 4 times a week (ET) and after 5 days of bed rest (HDBR) in 10 healthy males. We did not observe any significant changes in the basal levels of EPI, NE, and cortisol in the plasma, nor in the immune parameters after ET and HDBR. The exercise test led to a significant (P <.001) elevation of EPI and NE levels after both ET and HDBR, a significant elevation (P <.01) of cortisol after HDBR, an increase in the absolute numbers of leukocytes, granulocytes, monocytes, CD3+, CD4+, CD8+, CD16+, CD19+ lymphocytes, percentage of CD11a+ and CD11b+ lymphocytes, and to a decrease of CD62L1 before, after ET, and after HDBR. We found comparable changes in all measured immune parameters after ET and HDBR. In conclusion, repeated stress-induced elevation of EPI and NE was not associated with an alteration in immune cell redistribution found in response to the single bout of exercise.
Imrich
Richard
R
Institute of Experimental Endocrinology, SAS, Vlarska 3, 833 06 Bratislava, Slovakia. richard.imrich@savba.sk
Tibenska
Elena
E
Koska
Juraj
J
Ksinantova
Lucia
L
Kvetnansky
Richard
R
Bergendiova-Sedlackova
Katarina
K
Blazicek
Pavol
P
Vigas
Milan
M
D000328:Adult; D015703:Antigens, CD / Q000276:immunology; D002395:Catecholamines / Q000378:metabolism*; D006801:Humans; D016130:Immunophenotyping; D016131:Lymphocyte Subsets; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D013312:Stress, Physiological / Q000276:immunology / Q000378:metabolism*
D015703:Antigens, CD; D002395:Catecholamines