title: Syntheses and GABA uptake properties of 6-ether- and 6-enol ether-substituted nipecotic acids.
abstract: 6-aralkylether- and 6-arylenol-ether-substituted nipecotic acids were synthesized. These analogues are poor GABA uptake inhibitors. The electronegative region concept developed in the N-substituted nipecotic acid series cannot be transferred on the side chain of this series of 6-substituted analogues.
authors.affiliation: Laboratoire de pharmacochimie de la communication cellulaire UMR7081 du CNRS, faculté de pharmacie, 74 route du Rhin, 67401 Illkirch, France.
authors.forename: Victor
authors.initials: V
authors.lastname: N'Goka
authors.forename: Caterina
authors.initials: C
authors.lastname: Bissantz
authors.forename: Philippe
authors.initials: P
authors.lastname: Bisel
authors.forename: Tine B
authors.initials: TB
authors.lastname: Stenbøl
authors.forename: Povl
authors.initials: P
authors.lastname: Krogsgaard-Larsen
authors.forename: Gilbert
authors.initials: G
authors.lastname: Schlewer
mesh_terms: D004987:Ethers; D009557:Nipecotic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000493:pharmacokinetics*
chemical_list: D004987:Ethers; D009557:Nipecotic Acids; D005680:gamma-Aminobutyric Acid