title: Interventions in aging and age-associated pathologies by means of nutritional approaches.
abstract: So-called antioxidant strategies have not been shown convincingly to be effective in increasing life spans of animals. Thus, the general consensus of experimental gerontology in the last century was that the only reproducible means of prolonging survivals of animals is the calorie restriction paradigm. As a challenge against this dogma, we attempted to examine the effect of two potent antioxidants, one tetrahydrocurcumin (a biotransformed metabolite of curcumin contained in turmeric of Indian curry) and the other green tea polyphenols.
authors.affiliation: National Institute for Longevity Sciences, 36-3 Gengo, Morioka-cho, Obu-shi, Aichi 474-8522, Japan. kitani@nils.go.jp
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kitani
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Osawa
mesh_terms: D000375:Aging; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000473:pathology; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry; D008136:Longevity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009747:Nutritional Physiological Phenomena; D010636:Phenols / Q000737:chemistry; D059808:Polyphenols; D013662:Tea
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; C096277:tetrahydrocurcumin; D003474:Curcumin