Dehydroepiandrosterone sulfate increases hepatic ubiquinone-9 in male F-344 rats.
Administration of dehydroepiandrosterone sulfate (DHEAS) for 14 days caused a significant increase in the total ubiquinone-9 level in the hepatic tissue of male F-344 rats (p < 0.05). Hepatic ubiquinone-10 level of DHEAS-treated rats however, was found not to be statistically different from control animals. These findings suggest that peroxisome proliferator DHEAS displays typical hepatic response in increasing ubiquinone concentration in the rat.
Khan
S A
SA
Department of Pharmacology and Toxicology, Brody School of Medicine, East Pharmacol-Carolina University, Greenville, NC, USA. sak13@psu.edu
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D013268:Stimulation, Chemical; D014451:Ubiquinone / Q000378:metabolism*
D000975:Antioxidants; D014451:Ubiquinone; D019314:Dehydroepiandrosterone Sulfate; C030571:ubiquinone 9