title: Differential spatio-temporal expression of alpha-dystrobrevin-1 during mouse development.
abstract: Dystrobrevins are a family of dystrophin-related and dystrophin-associated proteins. alpha-dystrobrevin-1 knockout mice suffer from skeletal and cardiac myopathies. It has been suggested that the pathology is caused by the loss of signalling functions but the exact role of dystrobrevins is largely unknown. We have analysed the spatial and temporal expression of alpha-dystrobrevin-1 during mouse embryogenesis and found striking developmental regulation and distribution patterns. During development this protein was expressed not only in muscle but also in the CNS, sensory organs, epithelia and skeleton. Particularly interesting was the correlation of alpha-dystrobrevin-1 expression with the induction of various differentiation processes in the developing eye, inner ear, pituitary, blood-brain barrier, stomach epithelium and areas of the brain, dorsal root ganglia and spinal cord. In contrast, this specific expression at the induction phase decreased/disappeared at later stages of development.
authors.affiliation: Molecular Medicine Group, Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.
authors.forename: Chun Fu
authors.initials: CF
authors.lastname: Lien
authors.forename: Christina
authors.initials: C
authors.lastname: Vlachouli
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Blake
authors.forename: J Paul
authors.initials: JP
authors.lastname: Simons
authors.forename: Dariusz C
authors.initials: DC
authors.lastname: Górecki
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002490:Central Nervous System / Q000378:metabolism; D049029:Dystrophin-Associated Proteins / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D007150:Immunohistochemistry; D051379:Mice / Q000196:embryology* / Q000378:metabolism; D012679:Sense Organs / Q000378:metabolism
chemical_list: D049029:Dystrophin-Associated Proteins; C098885:dystrobrevin