title: Protective effects of mutant ubiquitin in transgenic mice.
abstract: The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and it is not unreasonable to expect that such benefits will include diseases of aging.
authors.affiliation: Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada. dgray@ohri.ca
authors.forename: D A
authors.initials: DA
authors.lastname: Gray
authors.forename: M
authors.initials: M
authors.lastname: Tsirigotis
authors.forename: J
authors.initials: J
authors.lastname: Brun
authors.forename: M
authors.initials: M
authors.lastname: Tang
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Beyers
authors.forename: J
authors.initials: J
authors.lastname: Woulfe
mesh_terms: D000375:Aging; D000818:Animals; D001831:Body Temperature; D001835:Body Weight; D002945:Cisplatin / Q000494:pharmacology; D003546:Cysteine Endopeptidases / Q000378:metabolism; D004249:DNA Damage; D051379:Mice; D008822:Mice, Transgenic; D009097:Multienzyme Complexes / Q000378:metabolism; D009154:Mutation; D046988:Proteasome Endopeptidase Complex; D012190:Retroviridae / Q000235:genetics; D013997:Time Factors; D025801:Ubiquitin / Q000235:genetics* / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D025801:Ubiquitin; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D002945:Cisplatin