title: Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex.
abstract: We developed a highly enantioselective separation system for the optically active compounds, (S)-ibuprofen and l-phenylalanine, from their racemic mixtures by employing a supported liquid membrane (SLM) encapsulating a surfactant-lipase complex (or a surfactant-alpha-chymotrypsin complex). In the present system, enzymes encapsulated in the liquid-membrane phase effectively drove the enantioselective transport of optically active compounds through the SLM. This novel SLM allowed high enantioselectivity (ee over 91%) in the optical resolution of racemic ibuprofen and phenylalanine.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, PRESTO, JST, Fukuoka 812-8581, Japan.
authors.forename: Eijiro
authors.initials: E
authors.lastname: Miyako
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Maruyama
authors.forename: Noriho
authors.initials: N
authors.lastname: Kamiya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Goto
mesh_terms: D002384:Catalysis; D002918:Chymotrypsin / Q000737:chemistry; D004798:Enzymes / Q000737:chemistry*; D004800:Enzymes, Immobilized / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry; D008049:Lipase / Q000737:chemistry; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D010649:Phenylalanine / Q000737:chemistry; D013237:Stereoisomerism; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D004798:Enzymes; D004800:Enzymes, Immobilized; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D013501:Surface-Active Agents; D010649:Phenylalanine; D008049:Lipase; D002918:Chymotrypsin; D007052:Ibuprofen