title: Corticosteroids treatment.
abstract: Corticosteroids (Cs) are widely used for treatment of multiple sclerosis (MS) acute relapses because of the potent immunosuppressive and anti-inflammatory properties. As for patients with relapsing-remitting (RR) MS, short-term administrations of Cs markedly less severity of symptoms and promote faster recovery of clinical attacks. Chronic administrations of Cs significantly diminish the formation of T1 hypointense lesions and the progression of brain atrophy. As for patients with secondary progressive MS treatment with Cs delays the time to onset of sustained disability. Finally the association between methylprednisolone and interferon beta (IFNbeta) leads the recovery of active lesions at greater extent and reduces the formation of neutralizing antibodies (NABs) against IFNbeta in patients with RRMS.
authors.affiliation: Department of Neurological Sciences, La Sapienza University, V.le Università 30, 00185 Rome, Italy. carlo.pozzilli@uniromal.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Pozzilli
authors.forename: Fabiana
authors.initials: F
authors.lastname: Marinelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Romano
authors.forename: Francesca
authors.initials: F
authors.lastname: Bagnato
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000906:Antibodies / Q000187:drug effects / Q000276:immunology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D016899:Interferon-beta / Q000276:immunology / Q000494:pharmacology; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D009410:Nerve Degeneration / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D055502:Secondary Prevention
chemical_list: D000305:Adrenal Cortex Hormones; D000906:Antibodies; D007166:Immunosuppressive Agents; D016899:Interferon-beta