title: P4 cap modified tetrapeptidyl alpha-ketoamides as potent HCV NS3 protease inhibitors.
abstract: We describe herein the design, syntheses, and biological evaluation of new series of P4 tetrazole and adipic acid, ester, amide capped tetrapeptidyl alpha-ketoamide based HCV protease inhibitors.
authors.affiliation: Lilly Research Laboratory, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
authors.forename: David X
authors.initials: DX
authors.lastname: Sun
authors.forename: Lifei
authors.initials: L
authors.lastname: Liu
authors.forename: Beverly
authors.initials: B
authors.lastname: Heinz
authors.forename: Alexander
authors.initials: A
authors.lastname: Kolykhalov
authors.forename: Jason
authors.initials: J
authors.lastname: Lamar
authors.forename: Robert B
authors.initials: RB
authors.lastname: Johnson
authors.forename: Q May
authors.initials: QM
authors.lastname: Wang
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Yip
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000577:Amides; D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases