The PIK3CA gene is mutated with high frequency in human breast cancers.
The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation. It has recently been reported that somatic mutations within the PI3K subunit p110alpha (PIK3CA) are present in human colorectal and other cancers. Here we show that thirteen of fifty-three breast cancers (25%) contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain. These results demonstrate that PIK3CA is the most mutated oncogene in breast cancer and support a role for PIK3CA in epithelial carcinogenesis.
Bachman
Kurtis E
KE
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Department of Oncology, Baltimore, Maryland 21231, USA. kbachman1@yahoo.com
Argani
Pedram
P
Samuels
Yardena
Y
Silliman
Natalie
N
Ptak
Janine
J
Szabo
Steve
S
Konishi
Hiroyuki
H
Karakas
Bedri
B
Blair
Brian G
BG
Lin
Clarence
C
Peters
Brock A
BA
Velculescu
Victor E
VE
Park
Ben Ho
BH
D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D058534:Class I Phosphatidylinositol 3-Kinases; D005091:Exons / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D020125:Mutation, Missense; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D019869:Phosphatidylinositol 3-Kinases; D058534:Class I Phosphatidylinositol 3-Kinases; C484760:PIK3CA protein, human