A new amidrazone derivative with antimycobacterial activity.
Of a series of pyridine-2-carboxamidrazone derivatives with activity against mycobacteria, the N(1)-[4-(1,1-dimethylpropyl)benzylidene] derivative reported here, C(18)H(22)N(4), is one of the most active. The predicted E isomer about the C11=N12 double bond is confirmed and intramolecular hydrogen bonding involving both amino H atoms helps to keep the molecule flat. The same donor and acceptor atoms also form intermolecular hydrogen bonds.
Billington
D C
DC
Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham B4 7ET, England.
Lowe
P R
PR
Rathbone
D L
DL
Schwalbe
C H
CH