Comparative mapping in farm animals.
This paper summarises the current status of comparative mapping in farm animals. For most of the major farm animal species, a wide range of genomic tools are now available to create high-resolution genetic and physical maps of the genome. For many farm animals, the use of radiation hybrid panels and sequence data from expressed sequence tag (EST) projects has accelerated the development of high-resolution comparative maps, with human--the model species for farm animals. These tools and comparative maps are being used to map and identify the genes at the loci for simple and complex traits. The development of detailed physical maps in farm animals based on radiation hybrid panels and bacterial artificial chromosome (BAC) contigs provides a direct link between the 'information-poor' maps of farm animals and the 'information-rich' genomes of human and other model organisms.
Burt
David W
DW
UK Centre for Functional Genomics in Farm Animanls, Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Midlothian, UK. Dave.Burt@bbsrc.ac.uk
D000818:Animals; D000829:Animals, Domestic / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D019295:Computational Biology; D019143:Evolution, Molecular; D020224:Expressed Sequence Tags; D016678:Genome; D023421:Models, Animal; D009626:Terminology as Topic