title: [Paroxysmal nocturnal hemoglobinuria revealed by hepatic vein thrombosis (Budd-Chiari syndrome) during Infliximab therapy].
abstract: We report the case of a 41-Year-old man presenting with hepatic vein thrombosis (Budd-Chiari syndrome) during Infliximab therapy for ankylosing spondylitis. The systematic work-up revealed paroxysmal nocturnal hemoglobinuria. One Year later the patient was receiving anticoagulation therapy and was in good condition. The role of Infliximab in the development of thrombosis in this patient with rare underlying thrombophilia is discussed.
authors.affiliation: Service d'Hépatogastroentérologie, Hôpital Trousseau, CHRU de Tours, 37044 Tours Cedex.
authors.forename: Enam
authors.initials: E
authors.lastname: Sobkeng Goufack
authors.forename: Saloua
authors.initials: S
authors.lastname: Mammou
authors.forename: Béatrice
authors.initials: B
authors.lastname: Scotto
authors.forename: Anne
authors.initials: A
authors.lastname: De Muret
authors.forename: Abdallah
authors.initials: A
authors.lastname: Maakaroun
authors.forename: Gérard
authors.initials: G
authors.lastname: Socie
authors.forename: Yannick
authors.initials: Y
authors.lastname: Bacq
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D006502:Budd-Chiari Syndrome / Q000139:chemically induced* / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D006457:Hemoglobinuria, Paroxysmal / Q000209:etiology*; D006801:Humans; D000069285:Infliximab; D008297:Male; D013167:Spondylitis, Ankylosing / Q000188:drug therapy
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab