title: Lung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong.
abstract: OBJECTIVE
  To study the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese.
  
  
  METHODS
  229 consecutive incident patients with a histological diagnosis of lung cancer from a regional hospital and 197 healthy population-based controls were recruited for this study between July 1999 and June 2001. Genetic polymorphisms of GSTT1 and GSTM1 were determined using PCR-based technique.
  
  
  RESULTS
  The frequencies of GSTT1 and GSTM1 null genotypes were 51.8 and 59.4% in healthy controls and 63 and 54.7%, respectively, in lung cancer patients. GSTP1 Val105/Val105 genotype was found in only 1% of healthy controls. The risk for lung cancer with GSTT1 null genotype was significantly higher, adjusted odds ratio (OR) 1.69, 95% confidence interval (CI) 1.12-2.56, compared with those with the GSTT1 genotype; the increase in risk was found only in non-smokers. GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer.
  
  
  CONCLUSIONS
  GSTT1 null genotype is associated with an increased risk for lung cancer in non-smoking Chinese in Hong Kong.
authors.affiliation: Department of Medicine, Queen Mary Hospital, The University of Hong Kong, SAR, PR China. mmwchan@hkucc.hku.hk
authors.forename: Moira
authors.initials: M
authors.lastname: Chan-Yeung
authors.forename: Kian Cheng
authors.initials: KC
authors.lastname: Tan-Un
authors.forename: Mary Sau Man
authors.initials: MS
authors.lastname: Ip
authors.forename: Kenneth Wah Tak
authors.initials: KW
authors.lastname: Tsang
authors.forename: Siu Pang
authors.initials: SP
authors.lastname: Ho
authors.forename: James Chung Man
authors.initials: JC
authors.lastname: Ho
authors.forename: Henry
authors.initials: H
authors.lastname: Chan
authors.forename: Wah Kit
authors.initials: WK
authors.lastname: Lam
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011336:Probability; D011379:Prognosis; D018570:Risk Assessment; D012907:Smoking / Q000009:adverse effects
chemical_list: D005982:Glutathione Transferase