Neutrophil degranulation: therapeutic targets in [NTP]O mediated neutrophil degranulation.
Extracellular nucleotide-induced stimulation and activation of peripheral blood neutrophil and subsequent degranulation plays a critical role in immediate type hypersensitivity reaction and other inflammatory diseases. The extracellular nucleotides stimulate a P2Y receptor(s) on human PMN with the pharmacological profile similar to that of the P2Y2 receptor. Based on a recent proposal on the molecular mechanism of [NTP]O-induced neutrophil degranulation, a scheme identifying the therapeutic targets, is suggested with potential avenues for attenuating PMN degranulation.
Kannan
Subburaj
S
Department of Physiology, School of Medicine, Temple University, Philadelphia, PA 19140, USA. skannan22@hotmail.com
D015550:Cell Degranulation / Q000502:physiology*; D015195:Drug Design; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D009504:Neutrophils / Q000502:physiology*; D009711:Nucleotides / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000378:metabolism
D009711:Nucleotides; D018048:Receptors, Purinergic P2