title: Clindamycin-resistant Streptococcus pyogenes: report of a case.
abstract: A sentinel isolate of clindamycin-resistant Streptococcus pyogenes from a case of mixed aerobic-anaerobic necrotizing fasciitis prompted our clinical laboratory to change its protocol and subsequently perform routine susceptibility testing on all S. pyogenes isolated from blood and soft tissue specimens. Emerging clindamycin resistance may have serious implications in the treatment of severe S. pyogenes infections.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. swalsh@partners.org
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Walsh
authors.forename: Mary Jane
authors.initials: MJ
authors.lastname: Ferraro
authors.forename: Marlene L
authors.initials: ML
authors.lastname: Durand
mesh_terms: D000328:Adult; D002981:Clindamycin / Q000008:administration & dosage* / Q000494:pharmacology; D017719:Diabetic Foot / Q000188:drug therapy / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D019115:Fasciitis, Necrotizing / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008826:Microbial Sensitivity Tests; D018570:Risk Assessment; D012720:Severity of Illness Index; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000302:isolation & purification; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D002981:Clindamycin