The prostate as a reservoir for HIV-1.
As the prostate can harbor bacterial and fungal pathogens, it was investigated as a reservoir for HIV. Nine men chronically infected with HIV participated in a crossover trial in which weekly semen samples were collected with and without previous prostate massage (PM). Six of the nine participants had undetectable seminal plasma(SP) HIV RNA in all samples without previous PM, but had detectable SP HIV RNA (> 25 copies/ml) in one to three samples collected after PM.
Smith
Davey M
DM
Department of Medicine, University of California, San Diego, CA, USA.
Kingery
Julie D
JD
Wong
Joseph K
JK
Ignacio
Caroline C
CC
Richman
Douglas D
DD
Little
Susan J
SJ
D018592:Cross-Over Studies; D004197:Disease Reservoirs; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015497:HIV-1; D006801:Humans; D008297:Male; D010808:Physical Examination; D011467:Prostate / Q000821:virology*; D011469:Prostatic Diseases / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D012661:Semen / Q000737:chemistry / Q000821:virology
D012367:RNA, Viral