title: Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of 2-azaanthraquinones.
abstract: As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the standard redox potentials of some 2-azaanthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the 2-azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has been further shown that the correlation can be enhanced by introducing an electronic properties, i.e. the atomic charges at the C5 and O12 atoms in the quinone skeleton ring and the HOMO energy as additional parameters.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658-8558, Japan. j-koyama@kobepharma-u.ac.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Koyama
authors.forename: Izumi
authors.initials: I
authors.lastname: Morita
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Osakai
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hotta
authors.forename: Junko
authors.initials: J
authors.lastname: Takayasu
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
mesh_terms: D000880:Anthraquinones / Q000494:pharmacology*; D000956:Antigens, Viral / Q000494:pharmacology*; D004594:Electrophysiology; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
chemical_list: D000880:Anthraquinones; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen