[Influence of liver lesions and vitamin K1 on bleeding after liver biopsy in patients with chronic renal failure].
OBJECTIVE
To investigate the influence of liver lesions and vitamin K1 on bleeding after liver biopsy in patients with chronic renal failure and hepatitis virus infection.


METHODS
Ninety-two renal transplant recipients on hemodialysis with hepatitis B or C virus infection received percutaneous liver biopsy. The severities of liver inflammation and fibrosis were evaluated by semi-quantitative technique. Thirty-four patients were given intramuscular injection of vitamin K1 before liver biopsy at the dose of 10 mg twice daily for 3 days.


RESULTS
The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.


CONCLUSIONS
Bleeding occurred with a relatively high incidence after liver biopsy in patients with chronic renal failure and hepatitis virus B or C infection; vitamin K1 before liver biopsy could not reduce the incidence of bleeding, which is not correlated with the degree of liver lesions.
Yang
Xiao-bing
XB
Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515 China. yxb7829@hotmail.com
Jiang
Jian-ping
JP
Zhang
Xun
X
D001706:Biopsy / Q000009:adverse effects*; D006470:Hemorrhage / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D010837:Vitamin K 1 / Q000627:therapeutic use*
D010837:Vitamin K 1