Structure-based design, synthesis, and in vitro evaluation of nonpeptidic neprilysin inhibitors.
Sahli
Stefan
S
Laboratorium für Organische Chemie, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
Stump
Bernhard
B
Welti
Tobias
T
Blum-Kaelin
Denise
D
Aebi
Johannes D
JD
Oefner
Christian
C
Böhm
Hans-Joachim
HJ
Diederich
François
F
D015195:Drug Design; D004341:Drug Evaluation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007093:Imidazoles / Q000737:chemistry; D066298:In Vitro Techniques; D008958:Models, Molecular; D015260:Neprilysin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D007093:Imidazoles; D015260:Neprilysin