title: Infertility among male UK veterans of the 1990-1 Gulf war: reproductive cohort study.
abstract: OBJECTIVE
  To examine the hypothesis that, theoretically at least, exposure to toxicants of the type present in the Gulf war could affect spermatogenesis, which might be observed as increased levels of infertility.
  
  
  METHODS
  Retrospective reproductive cohort analysis.
  
  
  METHODS
  Male UK Gulf war veterans and matched comparison group of non-deployed servicemen, surveyed by postal questionnaire.
  
  
  METHODS
  42,818 completed questionnaires were returned, representing response rates of 53% for Gulf veterans and 42% for non-Gulf veterans; 10,465 Gulf veterans and 7376 non-Gulf veterans reported fathering or trying to father pregnancies after the Gulf war.
  
  
  METHODS
  Failure to achieve conceptions (type I infertility) or live births (type II infertility) after the Gulf war, having tried for at least a year and consulted a doctor; time to conception among pregnancies fathered by men not reporting fertility problems.
  
  
  RESULTS
  Risk of reported infertility was higher among Gulf war veterans than among non-Gulf veterans (odds ratio for type I infertility 1.41, 95% confidence interval 1.05 to 1.89; type II 1.50, 1.18 to 1.89). This small effect was constant over time since the war and was observed whether or not the men had fathered pregnancies before the war. Results were similar when analyses were restricted to clinically confirmed diagnoses. Pregnancies fathered by Gulf veterans not reporting fertility problems also took longer to conceive (odds ratio for > 1 year 1.18, 1.04 to 1.34).
  
  
  CONCLUSIONS
  We found some evidence of an association between Gulf war service and reported infertility. Pregnancies fathered by Gulf veterans with no fertility problems also reportedly took longer to conceive.
authors.affiliation: Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, University of London, London WC1E 7HT. noreen.maconochie@lshtm.ac.uk
authors.forename: Noreen
authors.initials: N
authors.lastname: Maconochie
authors.forename: Pat
authors.initials: P
authors.lastname: Doyle
authors.forename: Claire
authors.initials: C
authors.lastname: Carson
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D008889:Military Personnel / Q000706:statistics & numerical data*; D016017:Odds Ratio; D018923:Persian Gulf Syndrome / Q000453:epidemiology*; D011247:Pregnancy / Q000706:statistics & numerical data*; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D006113:United Kingdom / Q000453:epidemiology