title: Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.
abstract: The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.
authors.affiliation: Department of Neuroscience, Kuopio University Hospital and University of Kuopio, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Helisalmi
authors.forename: B
authors.initials: B
authors.lastname: Dermaut
authors.forename: M
authors.initials: M
authors.lastname: Hiltunen
authors.forename: A
authors.initials: A
authors.lastname: Mannermaa
authors.forename: M
authors.initials: M
authors.lastname: Van den Broeck
authors.forename: M
authors.initials: M
authors.lastname: Lehtovirta
authors.forename: A M
authors.initials: AM
authors.lastname: Koivisto
authors.forename: S
authors.initials: S
authors.lastname: Iivonen
authors.forename: M
authors.initials: M
authors.lastname: Cruts
authors.forename: H
authors.initials: H
authors.lastname: Soininen
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053829:Amyloid Precursor Protein Secretases; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005387:Finland / Q000453:epidemiology; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D053764:Presenilin-1; D053766:Presenilin-2
chemical_list: D001057:Apolipoproteins E; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; C413604:nicastrin protein; D053829:Amyloid Precursor Protein Secretases