title: A suspected case of ornithine transcarbamylase deficiency in a cat.
abstract: An 18 month-old, intact female American Shorthair cat was presented for evaluation of stunted growth and postprandial depression. Fasting serum ammonia and serum bile acid concentrations were above reference ranges at 396 microg/dl and 6.5 micromol/ l and their postprandial concentrations were 785 microg/dl and 9.5 micromol/l, respectively. The initial tentative diagnosis of a portosystemic shunt was excluded by mesenteric portography and histopathology of the liver. The cat was then suspected of a urea cycle enzyme deficiency and its urine was analyzed by gas chromatography-mass spectrometry. A presumptive diagnosis of ornithine transcarbamylase deficiency was made on the basis of the detection of orotic acid and uracil.
authors.affiliation: Department of Clinical Pathology, Nippon Veterinary and Animal Science University, Tokyo, Japan.
authors.forename: Tsukimi
authors.initials: T
authors.lastname: Washizu
authors.forename: Makoto
authors.initials: M
authors.lastname: Washizu
authors.forename: Chunhua
authors.initials: C
authors.lastname: Zhang
authors.forename: Isamu
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Masaki
authors.initials: M
authors.lastname: Sawamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood; D002371:Cat Diseases / Q000175:diagnosis / Q000201:enzymology*; D002415:Cats; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000662:veterinary; D022124:Hyperammonemia / Q000662:veterinary; D009954:Ornithine Carbamoyltransferase / Q000096:biosynthesis / Q000378:metabolism; D020163:Ornithine Carbamoyltransferase Deficiency Disease / Q000175:diagnosis / Q000662:veterinary*; D009963:Orotic Acid / Q000652:urine; D011170:Portasystemic Shunt, Surgical; D011172:Portography / Q000662:veterinary; D019518:Postprandial Period; D014498:Uracil / Q000652:urine; D014556:Urine / Q000737:chemistry
chemical_list: D001647:Bile Acids and Salts; D014498:Uracil; D009963:Orotic Acid; D009954:Ornithine Carbamoyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase