Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese.
We determined the occurrence of the single nucleotide polymorphisms (SNPs) -403A/G and -28C/G in the promoter region of RANTES in 1082 Chinese blood donors from northern and southern China and 249 HIV patients from southern China. Compared to healthy adults, Chinese AIDS patients had a significantly higher frequency of the -403G allele and haplotype I, -403G/-28C (P < 0.05), and a lower frequency of the -403A/A genotype (P < 0.01). Symptomatic patients had a higher frequency of the -28G allele and a lower frequency of the -28C/C genotype (P < or = 0.01). The plasma RANTES level was significantly lower in blood donors homozygous for haplotype I than in those who were homozygous for haplotypes II and III (P < 0.05). The frequency of the -403G allele was found to be higher in Chinese than in indigenous Africans, but lower than in Caucasians, Hispanics, and African Americans. The frequency of the -28G allele was comparable in Chinese and Japanese; this allele is rare in other ethnic groups. Results suggest that -403G may be associated with increased susceptibility to HIV infection, while -28G may be associated with advanced disease progression. The impact of SNPs on HIV infection appears to be unique in Chinese.
Zhao
X-Y
XY
Department of Microbiology, the University of Hong Kong, Hong Kong SAR, China.
Lee
S S
SS
Wong
K H
KH
Chan
K C W
KC
Ma
S
S
Yam
W-C
WC
Yuen
K Y
KY
Ng
M H
MH
Zheng
B J
BJ
D018946:Chemokine CCL5 / Q000097:blood / Q000235:genetics*; D002681:China; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006678:HIV / Q000378:metabolism; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
D018946:Chemokine CCL5