No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions.
[reaction: see text] The concentration of organolithium, organomagnesium halide, and lithium diisopropylamide solutions can be reliably determined using No-D NMR spectroscopy by integration against the added internal standard 1,5-cyclooctadiene (COD) (or cyclooctene). In addition, common impurities and degradation products can be assessed.
Hoye
Thomas R
TR
Department of Chemistry, 207 Pleasant Street, SE, University of Minnesota, Minneapolis, Minnesota 55455, USA. hoye@chem.umn.edu
Eklov
Brian M
BM
Voloshin
Mikhail
M
D008094:Lithium / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
D009942:Organometallic Compounds; D008094:Lithium; D008274:Magnesium