Childhood sickle cell crises: clinical severity, inflammatory markers and the role of interleukin-8.
There is emerging consensus that a pro-inflammatory condition contributes to the vaso-occlusive complications of sickle cell disease (SCD). We evaluated the potential value of inflammatory mediators as early markers of severity of painful vaso-occlusive crises (VOC) in SCD. We assayed the plasma levels of cytokines, soluble vascular cell adhesion molecule-1, acute phase proteins, secretory phospholipase and standard hematologic indices.
Etienne-Julan
Maryse
M
Belloy
Marie-Sylvaine
MS
Decastel
Monique
M
Dougaparsad
Samuel
S
Ravion
Sylvie
S
Hardy-Dessources
Marie-Dominique
MD
D000755:Anemia, Sickle Cell / Q000097:blood*; D016207:Cytokines / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood* / Q000502:physiology; D012720:Severity of Illness Index; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D016207:Cytokines; D018836:Inflammation Mediators; D016209:Interleukin-8; D019010:Vascular Cell Adhesion Molecule-1