A unidirectional crosslinking strategy for HIV-1 protease dimerization inhibitors.
A novel strategy to identify potent HIV-1 protease dimerization inhibitors was developed using 12-aminododecanoic acid as a tether to crosslink interfacial peptides. The directionality of the southern peptide was changed from N-->C to C-->N as compared to previously reported inhibitors. The terminal amine of the southern peptide and side chains were further diversified to find essential functional groups for dimerization inhibition of HIV-1 protease.
Hwang
You Seok
YS
Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA.
Chmielewski
Jean
J
D003432:Cross-Linking Reagents / Q000737:chemistry*; D019281:Dimerization; D016333:HIV Protease / Q000187:drug effects*; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology
D003432:Cross-Linking Reagents; D017320:HIV Protease Inhibitors; D016333:HIV Protease