title: Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil.
abstract: BACKGROUND
  Helicobacter pylori eradication has become the standard treatment for peptic ulcer disease. Triple therapy with omeprazole plus two antibiotics has been used. Due to the lack of ideal treatment and the high rates of primary resistance to nitroimidazoles, the use of clarithromycin has been adopted.
  
  
  OBJECTIVE
  To determine the Helicobacter pylori eradication rates using lansoprazole, amoxicillin and clarithromycin for seven days, in patients with peptic ulcer disease in a well developed urban area in Brazil.
  
  
  METHODS
  This was a retrospective, open-label study carried out at the School of Medicine of the Fundação ABC. It included 130 patients with peptic ulcer disease (upper endoscopy) who had been tested positive for Helicobacter pylori infection (urease test, histology or breath test), without previous treatment. Patients were treated with lansoprazole 30 mg, amoxicillin 1,000 mg and clarithromycin 500 mg b.i.d., for seven days. Eradication was verified after 90 days.
  
  
  RESULTS
  Follow-up data were available for 94 patients. Their mean age was 52.23 years; 51.54% were woman, 84.31% white, 37.69% smokers, 20.77% using nonsteroidal anti-inflammatory drugs and 8.46% alcoholics. Upper endoscopy revealed that 78.46% had duodenal ulcers and 21.53% had gastric ulcers (a 4:1 DU:GU ratio). The eradication rates were 85.11% per protocol and 61.54% by intention to treat; 97% had no adverse effects.
  
  
  CONCLUSIONS
  Triple therapy using lansoprazole, amoxicillin and clarithromycin is well tolerated with high eradication rates and forms a good alternative for developing countries.
authors.affiliation: Department of Clinical Gastroenterology, Faculdade de Medicina da Fundação ABC, Santo André, São Paulo, Brazil.
authors.forename: Patrick
authors.initials: P
authors.lastname: Bellelis
authors.forename: Eliana Sueco Tibana
authors.initials: ES
authors.lastname: Samano
authors.forename: Ricardo Cruz
authors.initials: RC
authors.lastname: Nunes
authors.forename: Lia de Melo
authors.initials: Lde M
authors.lastname: Ribeiro
authors.forename: Ethel Zimberg
authors.initials: EZ
authors.lastname: Chehter
authors.forename: Wilson Roberto
authors.initials: WR
authors.lastname: Catapani
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001938:Brazil; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy; D012189:Retrospective Studies; D016896:Treatment Outcome; D014505:Urban Population
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents