Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives.
Novel 4"-alkoxy avermectin derivatives were synthesized via rhodium carbenoid mediated O-H insertion reaction and tested for antiparasite activity against Artemia salina and Caenorhabditis elegans.
Nagai
Kenichiro
K
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Shiomi
Kazuro
K
Sunazuka
Toshiaki
T
Harder
Achim
A
Turberg
Andreas
A
Omura
Satoshi
S
D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects; D003445:Crustacea / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D007559:Ivermectin; C019264:avermectin