Clonal evolution as pathogenetic mechanism in relapse of primary CNS lymphoma.
Comparative investigation of immunoglobulin (Ig) heavy chain gene rearrangements and DNA sequence analyses of a primary lymphoma of the CNS (PCNSL) and its recurrence revealed that both tumors used the same Ig gene segment. In addition to shared somatic mutations, the primary and the recurrent PCNSLs harbored somatic mutations unique to each tumor. Clonal evolution rather than subclone selection appears to underlie the development of tumor recurrence in this case.
Pels
H
H
Department of Neurology, University of Bonn, Germany.
Montesinos-Rongen
M
M
Schaller
C
C
Van Roost
D
D
Schlegel
U
U
Wiestler
O D
OD
Deckert
M
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology*; D001483:Base Sequence; D001943:Breast Neoplasms / Q000601:surgery; D002999:Clone Cells / Q000473:pathology*; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D004273:DNA, Neoplasm / Q000235:genetics; D054278:Embryonal Carcinoma Stem Cells; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D005803:Genes, Immunoglobulin; D018858:Germinal Center / Q000473:pathology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage; D008969:Molecular Sequence Data; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000601:surgery; D014411:Neoplastic Stem Cells / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology; D012074:Remission Induction; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D015173:Supratentorial Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013702:Temporal Lobe / Q000473:pathology* / Q000601:surgery
D004273:DNA, Neoplasm; D003561:Cytarabine; D008727:Methotrexate