[Epidemiological study of nasopharyngeal carcinoma risk in relatives of high-risk families in Guangdong].
OBJECTIVE
Familial clustering of NPC has been widely observed, however, related investigations were mainly involved in individual reports for high-risk families or case-control study with small sample size, so no quantitive evaluation for NPC risk in relatives of high-risk families documented in high-risk area until now. The purpose of the study was to estimate NPC risk among relatives of high-risk pedigrees in Guangong province, so as to provide information for genetic epidemiology and clinical genetic consultation.


METHODS
One hundred and thirteen high-risk pedigrees were collected in the Cancer Center of Sun Yat-sen University, and standardized incidence ratio (SIR) was used to estimate NPC risk of first degree relatives (FDR).


RESULTS
NPC risk was significantly higher in first degree relatives that in general population, and SIR was 37.55; in addition, SIRs were 50.72, 79.64, 7.12, and 33.58 in their brothers, sisters, fathers, and mothers respectively.


CONCLUSIONS
NPC risk of relatives in familial NPC pedigrees elevates 7.12 to 79.64 times in high-risk families.
Jia
Wei-Hua
WH
Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China.
Xu
Zong-Li
ZL
Feng
Bing-Jian
BJ
Huang
Li-Xi
LX
Yu
Xing-Juan
XJ
Feng
Qi-Sheng
QS
Zhang
Feng
F
Zeng
Yi-Xin
YX
D002681:China / Q000453:epidemiology; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors