title: Safety and efficacy of transurethral resection of prostate glands up to 150 ml: a prospective comparative study with 1 year of followup.
abstract: OBJECTIVE
  We investigated the safety and efficacy of transurethral resection of the prostate (TURP) for prostate glands between 70 and 150 ml.
  
  
  METHODS
  We prospectively evaluated 113 patients treated with TURP for benign prostatic hyperplasia. A total of 57 patients with a prostate volume of less than 70 ml were assigned to group 1, while 56 with a prostate volume of between 70 and 150 ml were assigned to group 2. Preoperative parameters considered in each patient were prostate volume, International Prostate Symptom Score (I-PSS), urinary flow rate measurement (Qmax) and post-void residual urine volume (PVR). Operative time, resected tissue weight and all complications were recorded. All patients were evaluated 3 months and 1 year postoperatively. Preoperative, perioperative and postoperative data on the 2 groups were compared.
  
  
  RESULTS
  Each group achieved significant improvement in I-PSS, Qmax and PVR. Operative time was significantly longer in group 2 but the complication rate was similar in the 2 groups. Group 2 resulted in better improvements in Qmax and I-PSS. At 1 year of followup PVR was significantly lower in group 1 than in group 2. Multivariate analysis revealed that only age was a significant independent predictor of complications, and only age and initial Qmax were independent predictive variables of outcome.
  
  
  CONCLUSIONS
  TURP for large prostate glands is a safe procedure without showing a different complication rate compared with TURP for recommended volumes. Patients with a baseline prostate volume of greater than 70 ml seem to achieve better improvement in obstruction and symptoms.
authors.affiliation: Department of Urology and Division of Urology, A. O. Umberto I-Torrette, Polytechnic University of the Marche Region, Ancona, Italy. g.munnonigro@univpm.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Muzzonigro
authors.forename: Giulio
authors.initials: G
authors.lastname: Milanese
authors.forename: Daniele
authors.initials: D
authors.lastname: Minardi
authors.forename: Mammoud
authors.initials: M
authors.lastname: Yehia
authors.forename: Andrea Benedetto
authors.initials: AB
authors.lastname: Galosi
authors.forename: Marco
authors.initials: M
authors.lastname: Dellabella
mesh_terms: D000368:Aged; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000601:surgery*; D020728:Transurethral Resection of Prostate; D016896:Treatment Outcome