title: Evaluation of malignant mesothelioma in central Anatolia: a study of 67 cases.
abstract: BACKGROUND
  Malignant mesothelioma (MM) is a fatal neoplasm which frequently results from exposure to asbestos or erionite.
  
  
  METHODS
  Sixty-seven patients with MM were seen between 1990 and 2001. Their clinical and radiological features, as well as the therapy, were retrospectively evaluated.
  
  
  RESULTS
  In 51 patients (76.1%), the MM was confined to the pleura, in 14 patients it was exclusively peritoneal and in two patients, it involved both areas. Of the 67 cases, 35 (52.2%) were women. The mean (+/- SD) age for all cases was 57.6+/-11.5 years. Dyspnea (67.2%), cough (55.2%) and chest pain (50.7%) were the most frequent symptoms of onset. Pleural effusion (92.4%) was the most common chest x-ray finding, whereas pleural effusion (60.8%), pleural nodules (34.7%) and pleural thickening (34.7%) were the most common computed tomography findings in pleural MM patients. The histological subtypes of MM were determined as epithelial in 60 patients (89.5%), sarcomatous in four patients (5.9%) and mixed in three patients (4.4%). Although 50.7% and 25.4% of the cases were exposed to erionite and asbestos, respectively, 23.9% of the cases recalled no exposure to asbestos or erionite. Exposures were environmental as opposed to occupational. Thirty-five patients (52.2%) were administered chemotherapy, and follow-up data were available for 22 patients. For these patients, the two-year survival rate was 22% and the two-year progression-free interval was 15.7%. There were no differences between patients with asbestos and erionite exposure.
  
  
  CONCLUSIONS
  MM should be considered when exudative pleural effusion is detected in a patient who has been exposed to asbestos or erionite. MM is a major public health problem in parts of Turkey and compulsory environmental control of fibrous mineral should be considered.
authors.affiliation: Department of Pulmonary Medicine, Medical Faculty, Kayseri Erciyes University, Turkey.
authors.forename: Inci
authors.initials: I
authors.lastname: Gulmez
authors.forename: Levent
authors.initials: L
authors.lastname: Kart
authors.forename: Hakan
authors.initials: H
authors.lastname: Buyukoglan
authors.forename: Ozlem
authors.initials: O
authors.lastname: Er
authors.forename: Suleyman
authors.initials: S
authors.lastname: Balkanli
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozesmi
mesh_terms: D000328:Adult; D000368:Aged; D001194:Asbestos / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D010996:Pleural Effusion / Q000209:etiology; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D014057:Tomography, X-Ray Computed; D014421:Turkey / Q000453:epidemiology; D017641:Zeolites / Q000009:adverse effects
chemical_list: C083174:erionite; D017641:Zeolites; D001194:Asbestos