Volume-independent mechanisms of hypertension in hemodialysis patients: clinical implications.
The renin-angiotensin and sympathetic nervous systems are often activated in hemodialysis (HD) patients; the pathogenesis of this condition is discussed. Medications aimed at reducing renin and sympathetic activity may improve the cardiovascular prognosis, independent of its effect on blood pressure. This knowledge has important implications for the choice of treatment in HD patients.
Blankestijn
Peter J
PJ
Department of Nephrology, University Medical Center, Utrecht, The Netherlands. P.J.Blankestijn@azu.nl
Ligtenberg
Gerry
G
D002395:Catecholamines / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000503:physiopathology; D006435:Renal Dialysis; D012084:Renin-Angiotensin System / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D002395:Catecholamines