title: Pulmonary gas distribution during ventilation with different inspiratory flow patterns in experimental lung injury -- a computed tomography study.
abstract: BACKGROUND
  There is still controversy about the optimal inspiratory flow pattern for ventilation of patients with acute lung injury. The aim of this study was to compare the effects of pressure-controlled ventilation (PCV) with a decelerating inspiratory flow with volume-controlled ventilation (VCV) with constant inspiratory flow on pulmonary gas distribution (PGD) in experimentally induced ARDS.
  
  
  METHODS
  Sixteen adult sheep were randomized to be ventilated with PCV or VCV after surfactant depletion by repeated bronchoalveolar lavage. Positive end-expiratory pressure (PEEP) was increased in a stepwise manner from zero end-expiratory pressure (ZEEP) to 7, 14 and 21 cm H(2)O in hourly intervals. Respiratory rate, inspiration-to-expiration ratio and tidal volume were kept constant. Central hemodynamics, gas exchange and airway pressures were measured. Electron beam computed tomographic (EBCT) scans of the entire lungs were performed at baseline (preinjury) and each level of end-expiratory pressure during an inspiratory and expiratory hold maneuver. The lungs were three-dimensionally reconstructed and volumetric assessments were made separating the lungs into four subvolumes classified as overinflated, normally aerated, poorly aerated and nonaerated.
  
  
  RESULTS
  Pressure-controlled ventilation led to a decrease in peak airway pressure and an increase in mean airway pressure. No differences between groups were found regarding plateau pressures, hemodynamics and gas exchange. Recruitment, defined as a decrease in expiratory lung volume classified as nonaerated, was similar in both groups and predominantly associated with PEEP. Overinflated lung volumes were increased with PCV.
  
  
  CONCLUSIONS
  In this model of acute lung injury, ventilation with decelerating inspiratory flow had no beneficial effects on PGD when compared with ventilation with constant inspiratory flow, while the increase in overinflated lung volumes may raise concerns regarding potential ventilator-associated lung injury.
authors.affiliation: Department of Anesthesiology and Critical Care, University Hospital of Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Heidelberg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Roth
authors.forename: T
authors.initials: T
authors.lastname: Luecke
authors.forename: B
authors.initials: B
authors.lastname: Deventer
authors.forename: A
authors.initials: A
authors.lastname: Joachim
authors.forename: P
authors.initials: P
authors.lastname: Herrmann
authors.forename: M
authors.initials: M
authors.lastname: Quintel
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D012756:Sheep; D014057:Tomography, X-Ray Computed