T cell replicative senescence: pleiotropic effects on human aging.
Long-term culture studies using CD8 T cells, the immune cells responsible for control of viral infection, have identified the major features of replicative senescence. Aging is associated with increased proportions of CD8 T cells with similar characteristics, such as absence of expression of the CD28 costimulatory molecule and reduced antiviral effector functions. Proinflammatory cytokines produced by senescent CD8 T cells also may exert pleiotropic suppressive effects on overall immune function and bone homeostasis. Thus, modulation of T cell replicative senescence may provide a comprehensive therapeutic strategy to prevent multiple age-associated pathologies.
Effros
Rita B
RB
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095-1732, USA. reffros@mednet.ucla.edu
D000375:Aging; D018106:CD28 Antigens / Q000096:biosynthesis; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D016922:Cellular Senescence; D006706:Homeostasis; D006801:Humans; D007107:Immune System; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology*
D018106:CD28 Antigens