title: A multicentre report from the Mexican Retinoblastoma Group.
abstract: BACKGROUND
  Retinoblastoma (RB) is a relatively uncommon tumour in childhood. The incidence of retinoblastoma in Mexico is probably higher than the incidence reported worldwide, however there is not enough information about the characteristics of this illness in Mexico. This report aims to present the results of a multicentre clinical survey of RB in Mexico.
  
  
  METHODS
  A retrospective study was carried out on all RB cases treated in 16 institutions during the last six years. The variables analysed were age at diagnosis, sex, affected eyes, treatment modalities, and pathological staging. Overall survival was obtained.
  
  
  RESULTS
  The authors analysed 500 cases; age range was 0-182 months. There were 364 unilateral cases (72.8%). Enucleation was performed in 84.9% of the patients. The St Jude's staging was: 7.4% stage I, 52.8% stage II, 18.0% stage III, 11.4% stage IV, 7.2% not evaluated, and 3.2% missing data. Chemotherapy was used in 74.4% of the patients. Disease free survival was 89% at 73 months follow up.
  
  
  CONCLUSIONS
  The paper presents a great number of cases and pioneers multicentre studies in paediatric ophthalmology and oncology in this country. Given the great number of patients in advanced stages and the variability on treatment schemes, it is evident that it is mandatory to work in a cooperative group and develop a national early detection programme as well as a treatment protocol which include all specialists involved in the care of patients with RB.
authors.affiliation: Instituto Nacional de Pediatría, DF, Mexico. drcarlosaleal@msn.com
authors.forename: C
authors.initials: C
authors.lastname: Leal-Leal
authors.forename: M
authors.initials: M
authors.lastname: Flores-Rojo
authors.forename: A
authors.initials: A
authors.lastname: Medina-Sansón
authors.forename: F
authors.initials: F
authors.lastname: Cerecedo-Díaz
authors.forename: S
authors.initials: S
authors.lastname: Sánchez-Félix
authors.forename: O
authors.initials: O
authors.lastname: González-Ramella
authors.forename: F
authors.initials: F
authors.lastname: Pérez-Pérez
authors.forename: R
authors.initials: R
authors.lastname: Gómez-Martínez
authors.forename: A
authors.initials: A
authors.lastname: Quero-Hernández
authors.forename: E
authors.initials: E
authors.lastname: Altamirano-Alvarez
authors.forename: F
authors.initials: F
authors.lastname: Alejo-González
authors.forename: J
authors.initials: J
authors.lastname: Figueroa-Carbajal
authors.forename: A
authors.initials: A
authors.lastname: Ellis-Irigoyen
authors.forename: I
authors.initials: I
authors.lastname: Tejocote-Romero
authors.forename: R
authors.initials: R
authors.lastname: Cervantes-Paz
authors.forename: F
authors.initials: F
authors.lastname: Pantoja-Guillén
authors.forename: L
authors.initials: L
authors.lastname: Vega-Vega
authors.forename: F
authors.initials: F
authors.lastname: Carrete-Ramírez
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009367:Neoplasm Staging; D019572:Retinal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D012175:Retinoblastoma / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D017678:Sex Distribution