Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism.
We investigated possible associations between subclinical hypothyroidism and atherosclerotic diseases (ischemic heart disease and cerebrovascular disease) and mortality. Of 2856 participants (mean age 58.5 yr) in a thyroid disease screening between 1984 and 1987, 257 subjects with subclinical hypothyroidism (TSH > 5.0 mU/liter) and 2293 control subjects (TSH range 0.6-5.0 mU/liter) were analyzed. In the baseline cross-sectional analysis, subclinical hypothyroidism was associated with ischemic heart disease independent of age, systolic blood pressure, body mass index, cholesterol, smoking, erythrocyte sedimentation rate, or presence of diabetes mellitus [odds ratio (OR), 2.5; 95% confidence interval (95% CI), 1.1-5.4 in total subjects and OR, 4.0; 95% CI, 1.4-11.5 in men] but not in women. However, there was no association with cerebrovascular disease (OR, 0.9; 95% CI, 0.4-2.4). We were unable to detect an influence of thyroid antibody presence on the association between subclinical hypothyroidism and ischemic heart disease. In a 10-yr follow-up study until 1998, increased mortalities from all causes in yr 3-6 after baseline measurement were apparent in men with subclinical hypothyroidism (hazard ratio, 1.9-2.1) but not in women, although specific causes of death were not determined. Our results indicate that subclinical hypothyroidism is associated with ischemic heart disease and might affect all-cause mortality in men.
Imaizumi
Misa
M
Department of Clinical Studies, Radiation Effects Research Foundation, 1-8-6 Nakagawa, Nagasaki 850-0013, Japan. misaima@rerf.or.jp
Akahoshi
Masazumi
M
Ichimaru
Shinichiro
S
Nakashima
Eiji
E
Hida
Ayumi
A
Soda
Midori
M
Usa
Toshiro
T
Ashizawa
Kiyoto
K
Yokoyama
Naokata
N
Maeda
Renju
R
Nagataki
Shigenobu
S
Eguchi
Katsumi
K
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology*; D015995:Prevalence; D016016:Proportional Hazards Models; D018570:Risk Assessment; D017678:Sex Distribution; D013961:Thyroid Gland / Q000276:immunology
D001323:Autoantibodies