Myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty.
There is substantial evidence indicating that endogenous opioid peptides are involved in the pathophysiology of myocardial ischemia and reperfusion. We measured the myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty. The results indicate that in patients with coronary artery disease, there was an augmented myocardial concentration of beta-endorphin. Moreover, there was an increased peripheral concentration of beta-endorphin following myocardial ischemia and reperfusion. The data support the previous notion that endogenous opioid peptides are involved in the pathophysiology of ischemic heart disease.
Chang
Michael Chich-Kuang
MC
Division of Cardiology, Jen Ai Hospital, Tali, Taichung. Taiwan, ROC.
Lee
Andrew Ying-Siu
AY
Lin
Wen-Ye
WY
Chen
Tien-Jen
TJ
Shyu
Miin-Yaw
MY
Chang
Wen-Fung
WF
D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D001794:Blood Pressure; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006339:Heart Rate; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000503:physiopathology; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000737:chemistry*; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D001615:beta-Endorphin / Q000032:analysis / Q000097:blood*
D007527:Isoenzymes; D019344:Lactic Acid; D001615:beta-Endorphin; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form