Protective effect of total flavones from Elsholtzia blanda (TFEB) on myocardial ischemia induced by coronary occlusion in canines.
This study was undertaken to determine the effect of total flavones from Elsholtzia blanda (Benth.) Benth. (TFEB), a traditional Chinese medicine, on myocardial ischemia induced by coronary occlusion in Beagle dogs. Infarct size of left ventricle, serum activity of creatine kinase-MB (CK-MB) and malondialdehyde (MDA), hemorrheologic variables and homodynamic parameters including mean arterial pressure (MAP), coronary blood flow (CBF), coronary vascular resistance (CVR), end-diastolic pressure of left ventricle (LVEDP), rate of rise and decline of left ventricular pressure (+/-dp/dtmax) were measured in this study. Administration with TFEB produced a dose-dependent reduction in infarct size. TFEB 100 mg/kg exerted notable inhibition in the elevation of serum CK-MB and MDA activity. TFEB significantly reduced MAP and CVR. The decrease in CBF also tended to be smaller in treated dogs. TFEB improved the recovery of myocardial function by depressing the degree of reduction in +/-dp/dtmax and LVEDP. TFEB also showed a capacity to resist ischemic damage through lowering blood viscosity. The results indicated that TFEB kept heart from ischemic damage due to coronary occlusion in Beagle dogs.
Haiyun
Ling
L
Department of Pharmacology and Toxicology, Zhejiang University, Hangzhou 310031, PR China.
Yijia
Lou
L
Honggang
Lou
L
Honghai
Wu
W
D000818:Animals; D003327:Coronary Disease / Q000150:complications*; D003402:Creatine Kinase / Q000097:blood; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D047309:Flavones / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D018056:Hemorheology / Q000187:drug effects; D019686:Lamiaceae; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D017202:Myocardial Ischemia / Q000209:etiology / Q000517:prevention & control*; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; D047309:Flavones; D008315:Malondialdehyde; D003402:Creatine Kinase