Nitric oxide, oxidative stress, and progression of chronic renal failure.
Cellular injury or organ dysfunction from oxidative stress occurs when reactive oxygen species (ROS) accumulate in excess of the host defense mechanisms. The deleterious effect of ROS occurs from 2 principal actions. First, ROS can inactivate mitochondrial enzymes, damage DNA, or lead to apoptosis or cellular hypertrophy. Second, nitric oxide (NO), which is a principal endothelial-derived relaxing factor, reacts with superoxide anion (O2-) to yield peroxynitrite (ONOO-), which is a powerful oxidant and nitrosating agent. The inactivation of NO by O2- creates NO deficiency. Oxidative stress can promote the production of vasoconstrictor molecules and primary salt retention by the kidney. Several hypertensive animal models showed increased activity of nicotine adenine dinucleotide phosphate (NADPH) oxidase, which is the chief source of O2- in the vessel wall and kidneys. NO regulates renal blood flow, tubuloglomerular feedback (TGF), and pressure natriuresis. Animal models of NO deficiency develop hypertension, proteinuria, and glomerulosclerosis. Evidence is presented that chronic renal failure (CRF) is a state of NO deficiency secondary to decreased kidney NO production and/or increased bioinactivation of NO by O2-. Patients with CRF show decreased endothelium-dependent vasodilatation to acetylcholine, have increased markers of oxidative stress, and diminished antioxidant activity. Therapy for oxidative stress has focused on antioxidants and agents that modify the renin-angiotensin system. The effects of such treatments are more compelling in animal models than in human studies.
Modlinger
Paul S
PS
Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20007, USA.
Wilcox
Christopher S
CS
Aslam
Shakil
S
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D004195:Disease Models, Animal; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology* / Q000503:physiopathology* / Q000628:therapy; D007677:Kidney Function Tests; D009569:Nitric Oxide / Q000378:metabolism*; D018384:Oxidative Stress; D011379:Prognosis; D006435:Renal Dialysis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D000975:Antioxidants; D009569:Nitric Oxide