title: Three-chamber priapism in a patient with primary epithelioid hemangioendothelioma of penis.
abstract: A 58-year-old man presented with a 6-month history of painful progressive penile firmness, initially diagnosed as Peyronie's disease. Penile fibrosis involved the entire corpora cavernosa and spongiosum, making it consistent with three-chamber priapism. Cavernosal biopsies revealed epithelioid hemangioendothelioma, and the metastatic workup found hepatic and pulmonary lesions. The patient was treated with paclitaxel, but eventually died of cancer progression. Early infiltrative vascular malignancies of the penis may be indistinguishable from Peyronie's disease. A review of published reports revealed that penile masses associated with progressive growth, obstructive urinary symptoms, dysuria, or painful erections might warrant further evaluation with biopsies.
authors.affiliation: Department of Urology, Boston University, Boston, Massachusetts, USA.
authors.forename: C Charles
authors.initials: CC
authors.lastname: Wen
authors.forename: Ricardo
authors.initials: R
authors.lastname: Munarriz
authors.forename: Irwin
authors.initials: I
authors.lastname: Goldstein
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001706:Biopsy; D003951:Diagnostic Errors; D005188:False Negative Reactions; D017809:Fatal Outcome; D018323:Hemangioendothelioma, Epithelioid / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use; D010411:Penile Induration / Q000175:diagnosis; D010412:Penile Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D011317:Priapism / Q000209:etiology*; D014555:Urination Disorders / Q000209:etiology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel