title: The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease.
abstract: Immunohistochemical techniques revealed a significant increase of poly(ADP-ribose) polymerase (PARP)-containing nuclei in the dopaminergic neurons of the substantia nigra (SN) in Parkinson disease and in diffuse Lewy body disease as compared with a group of patients with other neurodegenerative diseases and normal controls. The nuclear translocation of nuclear factor kappa B (NF-kappa B) was also noted in the same cells. The over-activation of PARP and the transcriptional activation of NF-kappa B can contribute to the pathomechanism of the disease specific lesion of the neurons in the SN. However, in another subgroup of dopaminergic cells of the SN an increased parvalbumin content was detected reflecting a natural protective mechanism against the putative increase of intracellular calcium caused by excitotoxic injury and oxidative stress.
authors.affiliation: Department of Neurology, University of Szeged, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Soós
authors.forename: József I
authors.initials: JI
authors.lastname: Engelhardt
authors.forename: László
authors.initials: L
authors.lastname: Siklós
authors.forename: László
authors.initials: L
authors.lastname: Havas
authors.forename: Katalin
authors.initials: K
authors.lastname: Majtényi
mesh_terms: D006801:Humans; D016328:NF-kappa B / Q000032:analysis / Q000096:biosynthesis*; D010300:Parkinson Disease / Q000201:enzymology* / Q000378:metabolism; D010320:Parvalbumins / Q000032:analysis / Q000096:biosynthesis*; D011065:Poly(ADP-ribose) Polymerases / Q000032:analysis / Q000096:biosynthesis*; D013378:Substantia Nigra / Q000737:chemistry / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D016328:NF-kappa B; D010320:Parvalbumins; D011065:Poly(ADP-ribose) Polymerases