Diffusion measurements free of motion artifacts using intermolecular dipole-dipole interactions.
Diffusion encoding, or diffusion weighting, is commonly achieved by applying a pair of balanced pulsed-field gradients during spin evolution. An alternative way to obtain diffusion measurements is to select dipolar correlation distances using the distant dipolar field (DDF) in systems with abundant spin density, such as water in tissues. Diffusion weighting using this effect is unique in that the refocusing "gradient" is carried within the sample, and thus the macroscopic motion of the sample is not expected to interfere with signal formation. The experiments presented here demonstrate that in moving phantoms, the phase shift of the signal due to linear motion is minimal in diffusion-weighted (DW) DDF measurements, and that motion artifacts in images of moving phantoms and the abdomen of live mice are small compared to standard pulsed-field-gradient methods. The technique may facilitate the use of DWI in typically motion-prone regions such as the abdomen, lungs, and heart.
Kennedy
Scott D
SD
Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York 14642, USA. scott_kennedy@urmc.rochester.edu
Zhong
Jianhui
J
D000005:Abdomen / Q000033:anatomy & histology*; D000818:Animals; D016477:Artifacts; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D019047:Phantoms, Imaging