title: Clinical features of patients with chronic pancreatitis complicated by bile duct strictures.
abstract: OBJECTIVE
  Distal bile duct stenosis is relatively rare in patients with non-alcoholic chronic pancreatitis.
  
  
  METHODS
  The clinical features of eight patients who had chronic pancreatitis complicated by bile duct strictures who underwent surgical treatments were reviewed.
  
  
  RESULTS
  Ages ranged from 38 to 80 years, with a mean of 53.4 years. All but one patient were male. Six patients had moderate or slight epigastric pain. Five patients had obstructive jaundice and underwent biliary drainage. All patients had liver dysfunction due to biliary obstruction. Although four of the eight patients were heavy or moderate drinkers, none of the patients had a history of chronic pancreatitis. Stricture shapes of the common bile ducts were smooth and tapering in five patients, funnel-shaped in two, and rat-tail in one. Four patients underwent a pancreatoduodenectomy and one patient underwent a pylorus-preserving pancreatoduodenectomy for clinically suspected pancreatic malignancy that was later proven histopathologically to be chronic pancreatitis. The other three patients underwent a choledochoduodenostomy. There were no postoperative complications or deaths. During the follow-up period, all patients were asymptomatic.
  
  
  CONCLUSIONS
  In conclusion, bile duct stricture potentially occurs not only in patients with alcoholic chronic pancreatitis but also in patients with nonalcoholic chronic pancreatitis. Furthermore, in some cases, it is impossible to differentiate chronic pancreatitis from pancreatic or periampullary malignancy.
authors.affiliation: Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan. kimura-f@umin.ac.jp
authors.forename: Fumio
authors.initials: F
authors.lastname: Kimura
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Suwa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sugiura
authors.forename: Tokuzou
authors.initials: T
authors.lastname: Shinoda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood; D002758:Cholangiography; D002768:Choledochostomy; D002908:Chronic Disease; D003137:Common Bile Duct Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology* / Q000601:surgery; D003251:Constriction, Pathologic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging; D016577:Pancreaticoduodenectomy; D010195:Pancreatitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D019512:Pancreatitis, Alcoholic / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D051381:Rats; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor