[Experimental study on preventive effect of Radix Paeoniae Rubra to restenosis after carotid balloon injury in high fat-diet rabbits].
OBJECTIVE
To observe the preventive effect of Radix Paeoniae Rubra (RPR) to restenosis after carotid balloon injury in rabbits.


METHODS
The rabbit model of carotid balloon injury was established adopting Clowes method, and treated with extract of RPR. Component of new genesic intima and expression of proliferating cell nuclear antigen (PCNA) and macrophage was determined by immunochemical stain. The collagen of type I was detected by special staining for blood vessels and the area of new genesic intima was measured by image assay system.


RESULTS
RPR could remarkably decreased the PCNA positive expression and inhibit the proliferation of collagen type I and reduce the generating of new intima.


CONCLUSIONS
RPR has significant preventive effect on the restenosis after carotid ballon injury in high fat-diet induced atherosclerotic rabbits.
Zhu
Hui-min
HM
Chengdu University of TCM, Chengdu (610075). atbao@sina.com
Zhu
Bi-de
BD
D000800:Angioplasty, Balloon / Q000009:adverse effects*; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology / Q000628:therapy; D020212:Carotid Artery Injuries / Q000209:etiology; D017536:Carotid Artery, Common / Q000473:pathology; D016893:Carotid Stenosis / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000150:complications; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D029596:Paeonia; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011817:Rabbits; D055502:Secondary Prevention
D004365:Drugs, Chinese Herbal; D018809:Proliferating Cell Nuclear Antigen