Genetic pathways and new progression markers for prostate cancer defined by microsatellite allelotyping.
A prospective study was carried out on a large cohort of males undergoing radical retropubic prostatectomy in order to identify genetic marker regions significantly associated with tumor formation. By comprehensive allotyping of chromosomes known to be associated with prostate carcinogenesis, an algorithm could be formulated for the genetic pathway and a method of discrimination between aggressive and less aggressive forms could be identified.
von Knobloch
Rolf
R
Department of Urology, Philipps-University Marburg Medical School, Marburg/Lahn, Germany. Rolf.von-Knobloch@med.uni-marburg.de
Konrad
Lutz
L
Barth
Peter J
PJ
Brandt
Heidrun
H
Wille
Sebastian
S
Heidenreich
Axel
A
Moll
Roland
R
Hofmann
Rainer
R
D000483:Alleles; D022981:Allelic Imbalance; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002874:Chromosome Mapping; D015331:Cohort Studies; D018450:Disease Progression; D006580:Genetic Carrier Screening; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D016160:Retinoblastoma Protein / Q000235:genetics
D005819:Genetic Markers; D016160:Retinoblastoma Protein