title: Genetic pathways and new progression markers for prostate cancer defined by microsatellite allelotyping.
abstract: A prospective study was carried out on a large cohort of males undergoing radical retropubic prostatectomy in order to identify genetic marker regions significantly associated with tumor formation. By comprehensive allotyping of chromosomes known to be associated with prostate carcinogenesis, an algorithm could be formulated for the genetic pathway and a method of discrimination between aggressive and less aggressive forms could be identified.
authors.affiliation: Department of Urology, Philipps-University Marburg Medical School, Marburg/Lahn, Germany. Rolf.von-Knobloch@med.uni-marburg.de
authors.forename: Rolf
authors.initials: R
authors.lastname: von Knobloch
authors.forename: Lutz
authors.initials: L
authors.lastname: Konrad
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Barth
authors.forename: Heidrun
authors.initials: H
authors.lastname: Brandt
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wille
authors.forename: Axel
authors.initials: A
authors.lastname: Heidenreich
authors.forename: Roland
authors.initials: R
authors.lastname: Moll
authors.forename: Rainer
authors.initials: R
authors.lastname: Hofmann
mesh_terms: D000483:Alleles; D022981:Allelic Imbalance; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002874:Chromosome Mapping; D015331:Cohort Studies; D018450:Disease Progression; D006580:Genetic Carrier Screening; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D016160:Retinoblastoma Protein / Q000235:genetics
chemical_list: D005819:Genetic Markers; D016160:Retinoblastoma Protein