title: Cytotoxic-antineoplastic activity of acetyl derivatives of prenylnaphthohydroquinone.
abstract: Several acetyl derivatives of prenylnaphthohydroquinone have been synthetized and evaluated for their cytotoxicity against A-549 human lung carcinoma and H-116 human colon carcinoma neoplastic cells. The IC50 values against A-549 are compared with those observed for previously reported unsubstituted derivatives.
authors.affiliation: Instituto de Química, Pontificia Universidad Católica de Valparaíso, Avenida Brazil 2950, Casilla 4059 Valparaíso, Chile. amolinar@ucv.cl
authors.forename: Aurora
authors.initials: A
authors.lastname: Molinari
authors.forename: Alfonso
authors.initials: A
authors.lastname: Oliva
authors.forename: José María Miguel
authors.initials: JM
authors.lastname: del Corral
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Castro
authors.forename: Claudia
authors.initials: C
authors.lastname: Araya
authors.forename: María Dolores
authors.initials: MD
authors.lastname: García-Grávalos
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D006873:Hydroquinones; D009285:Naphthoquinones; C493261:prenylnaphthohydroquinone