A sheer pharmacologic approach to compare the contractile effects of PGF2alpha, DL-cloprostenol and D-cloprostenol on isolated uterine, tracheal, ileal and arterial smooth muscle preparations.
The contractile effects of PGF2alpha and its cloprostenol analogs (D-enantiomer and racemate) were examined on isolated smooth muscle preparations (uterine, tracheal, ileal and arterial) from rat, guinea-pig and horse. DL- and D-cloprostenol were potent contractors of myometrium, but had negligible secondary effects on other types of smooth muscle, except artery whose response to the D-enantiomer may give rise to some concern.
Beretta
C
C
Department of Clinical Veterinary Sciences, University of Milan, Via Celoria 10, Milan 20133, Italy.
Cavalli
M
M
D000818:Animals; D001158:Arteries; D002217:Carbachol / Q000494:pharmacology; D003008:Cloprostenol / Q000494:pharmacology*; D015237:Dinoprost / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006736:Horses; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects / Q000502:physiology; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D010656:Phenylephrine; D012701:Serotonin; D003008:Cloprostenol; D002217:Carbachol; D015237:Dinoprost