Extramedullary relapse confirmed by fluorescence in situ hybridization study of an ear mass in acute promyelocytic leukemia.
A 40-year-old man with acute promyelocytic leukemia (APL) achieved complete remission after induction chemotherapy combined with all-trans-retinoic acid. A mass developed in the left ear 24 months later. Relapse of APL was suspected at morphologic examination of the biopsy specimen of the ear mass, but t(15;17) and PML/RAR alpha rearrangement were not detected by chromosomal, fluorescence in situ hybridization (FISH), or reverse transcription polymerase chain reaction analysis of bone marrow samples. FISH performed on the ear mass revealed t(15;17). To our knowledge, this case is the first reported case of extramedullary relapse of APL confirmed by FISH study of a biopsy specimen of extramedullary tissue.
Lee
Keun-Wook
KW
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Yi
Jongyoun
J
Yun
Tak
T
Kim
Dae-Young
DY
Lee
Dong Soon
DS
Park
Sung Sup
SS
Cho
Han Ik
HI
Yoon
Sung-Soo
SS
Park
Seonyang
S
Kim
Byoung Kook
BK
Kim
Noe Kyeong
NK
D000328:Adult; D001706:Biopsy; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15; D004428:Ear Neoplasms / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction