title: Diaminopyrimidine and diaminopyridine 5-HT7 ligands.
abstract: The present studies have identified a series of diaminopyrimidines and diaminopyridines as novel 5-HT(7) receptor ligands. Three regiosiomeric classes of pyrimidines and four regioisomeric classes of pyridines were synthesized and analyzed for binding to the 5-HT(7) receptor. The 5-HT(7) binding affinities of different regioisomers show clearly the structure-activity relationship with position of ring nitrogens.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. derek.denhart@bms.com
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Denhart
authors.forename: Ashok V
authors.initials: AV
authors.lastname: Purandare
authors.forename: John D
authors.initials: JD
authors.lastname: Catt
authors.forename: H Dalton
authors.initials: HD
authors.lastname: King
authors.forename: Aiming
authors.initials: A
authors.lastname: Gao
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Deskus
authors.forename: Michael A
authors.initials: MA
authors.lastname: Poss
authors.forename: Arlene D
authors.initials: AD
authors.lastname: Stark
authors.forename: John R
authors.initials: JR
authors.lastname: Torrente
authors.forename: Graham
authors.initials: G
authors.lastname: Johnson
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Mattson
mesh_terms: D008024:Ligands; D011725:Pyridines / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D008024:Ligands; D011725:Pyridines; D011743:Pyrimidines; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor