title: Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism.
abstract: We investigated possible associations between subclinical hypothyroidism and atherosclerotic diseases (ischemic heart disease and cerebrovascular disease) and mortality. Of 2856 participants (mean age 58.5 yr) in a thyroid disease screening between 1984 and 1987, 257 subjects with subclinical hypothyroidism (TSH > 5.0 mU/liter) and 2293 control subjects (TSH range 0.6-5.0 mU/liter) were analyzed. In the baseline cross-sectional analysis, subclinical hypothyroidism was associated with ischemic heart disease independent of age, systolic blood pressure, body mass index, cholesterol, smoking, erythrocyte sedimentation rate, or presence of diabetes mellitus [odds ratio (OR), 2.5; 95% confidence interval (95% CI), 1.1-5.4 in total subjects and OR, 4.0; 95% CI, 1.4-11.5 in men] but not in women. However, there was no association with cerebrovascular disease (OR, 0.9; 95% CI, 0.4-2.4). We were unable to detect an influence of thyroid antibody presence on the association between subclinical hypothyroidism and ischemic heart disease. In a 10-yr follow-up study until 1998, increased mortalities from all causes in yr 3-6 after baseline measurement were apparent in men with subclinical hypothyroidism (hazard ratio, 1.9-2.1) but not in women, although specific causes of death were not determined. Our results indicate that subclinical hypothyroidism is associated with ischemic heart disease and might affect all-cause mortality in men.
authors.affiliation: Department of Clinical Studies, Radiation Effects Research Foundation, 1-8-6 Nakagawa, Nagasaki 850-0013, Japan. misaima@rerf.or.jp
authors.forename: Misa
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Masazumi
authors.initials: M
authors.lastname: Akahoshi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ichimaru
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakashima
authors.forename: Ayumi
authors.initials: A
authors.lastname: Hida
authors.forename: Midori
authors.initials: M
authors.lastname: Soda
authors.forename: Toshiro
authors.initials: T
authors.lastname: Usa
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Ashizawa
authors.forename: Naokata
authors.initials: N
authors.lastname: Yokoyama
authors.forename: Renju
authors.initials: R
authors.lastname: Maeda
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Nagataki
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology*; D015995:Prevalence; D016016:Proportional Hazards Models; D018570:Risk Assessment; D017678:Sex Distribution; D013961:Thyroid Gland / Q000276:immunology
chemical_list: D001323:Autoantibodies