Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition.
1. The characteristics of semicarbazide-sensitive amine oxidase (SSAO) are reviewed and the unknown physiological or pathological role of this enzyme emphasized. 2. The various mechanisms of action proposed for the vasodilator drug hydralazine are considered. In particular, the inhibitory action on various enzymes, related or not to cardiovascular function, are discussed. 3. Studies linking inhibition of SSAO to hydralazine hypotension are reviewed and a general hypothesis relating both actions is presented. The hypothesis postulates that (a). vascular SSAO is involved in the regulation of vascular tone, and (b). hydralazine vasodilation is the consequence of vascular SSAO inhibition. 4. Evidence supporting these postulates is presented and vascular SSAO inhibition is proposed as a novel mechanism of vasodilation.
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Department of Pharmacology, School of Medicine, Universidad Nacional Autonoma de México, Apartado Postal 70297, 04510 México, D F, México.
D006631:Amine Oxidase (Copper-Containing) / Q000502:physiology*; D000818:Animals; D006801:Humans; D006830:Hydralazine / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D007022:Hypotension / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D006830:Hydralazine; D006631:Amine Oxidase (Copper-Containing)