Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus.
The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s<0.1 microM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.
Di Grandi
Martin J
MJ
Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. digranm@wyeth.com
Curran
Kevin J
KJ
Feigelson
Gregg
G
Prashad
Amar
A
Ross
Adma A
AA
Visalli
Robert
R
Fairhurst
Jeanette
J
Feld
Boris
B
Bloom
Jonathan D
JD
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D013890:Thiourea