title: Early-life programming of aging and longevity: the idea of high initial damage load (the HIDL hypothesis).
abstract: In this study, we test the predictions of the high initial damage load (HIDL) hypothesis, a scientific idea that early development of living organisms produces an exceptionally high load of initial damage, which is comparable with the amount of subsequent aging-related deterioration accumulating during the rest of the entire adult life. This hypothesis predicts that even small progress in optimizing the early-developmental processes can potentially result in a remarkable prevention of many diseases in later life, postponement of aging-related morbidity and mortality, and significant extension of healthy life span.
authors.affiliation: Center on Aging, National Opinion Research Center and University of Chicago, IL 60637-2745, USA. gavrilov@longevity-science.org
authors.forename: Leonid A
authors.initials: LA
authors.lastname: Gavrilov
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Gavrilova
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging; D005260:Female; D006801:Humans; D008017:Life Expectancy; D008136:Longevity; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010331:Paternal Age; D013997:Time Factors