Repetitive propofol administration in dogs and cats.
A bolus of propofol was administered to 10 dogs (6 mg/kg intravenously [IV]) and 10 cats (10 mg/kg IV) on three consecutive days. The occurrence of apnea, heart and respiratory rates, blood pressure, time to movement, and changes in a complete blood count and biochemical profile were recorded. Apnea was not seen in the dogs but was seen in three cats. Slight increases in the number of Heinz bodies were seen in six cats, but the increases were not considered clinically significant. No apparent cumulative adverse effects were seen from a bolus of bisulfite-containing propofol, administered on three consecutive days.
Matthews
Nora S
NS
Departments of Small Animal Medicine and Surgery, Texas A & M University, College Station, Texas 77843-4474, USA.
Brown
Raquel M
RM
Barling
Kerry S
KS
Lovering
Sandra L
SL
Herrig
Brent W
BW
D000771:Anesthesia, Intravenous / Q000379:methods / Q000662:veterinary*; D018686:Anesthetics, Intravenous / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D001049:Apnea / Q000453:epidemiology / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D002371:Cat Diseases / Q000139:chemically induced / Q000453:epidemiology; D002415:Cats / Q000502:physiology*; D004283:Dog Diseases / Q000139:chemically induced / Q000453:epidemiology; D004285:Dogs / Q000502:physiology*; D005260:Female; D006366:Heinz Bodies / Q000187:drug effects; D007262:Infusions, Intravenous / Q000662:veterinary; D008297:Male; D015742:Propofol / Q000009:adverse effects / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects
D018686:Anesthetics, Intravenous; D015742:Propofol