title: Accuracy of objective ambulatory accelerometry in detecting motor complications in patients with Parkinson disease.
abstract: Shortcomings of existing assessment methods in Parkinson disease (PD) have led to the development of continuous ambulatory multichannel accelerometry for the assessment of the core features of PD. Although measures for hypokinesia, bradykinesia, and tremor have been validated in groups of patients with PD, it is unclear whether this method is able to detect "on" with or without dyskinesias, and "off" in individual PD patients. This study therefore addressed the accuracy of objective ambulatory accelerometry in detecting motor complications in 15 PD patients, using a self-assessment scale as gold standard. Measures for hypokinesia, bradykinesia, and tremor showed limited sensitivity (0.60-0.71) and specificity (0.66-0.76) for motor complications in individual PD patients. In the group of PD patients, comparing the "on" with the "off" state yielded statistically significant differences for tremor only. Objective dyskinesia measures correlated with time spent with dyskinesias (r = 0.89). Although validated for the measurement of hypokinesia, bradykinesia, and tremor, continuous ambulatory multichannel accelerometry currently cannot detect "on" and "off" in individual PD patients.
authors.affiliation: Department of Neurology, Leiden University Medical Center, The Netherlands.
authors.forename: J I
authors.initials: JI
authors.lastname: Hoff
authors.forename: V
authors.initials: V
authors.lastname: van der Meer
authors.forename: J J
authors.initials: JJ
authors.lastname: van Hilten
mesh_terms: D000368:Aged; D005260:Female; D005684:Gait; D006801:Humans; D018476:Hypokinesia / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation / Q000379:methods*; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity