The upregulation of cognate and inducible heat shock proteins in the anoxic turtle brain.
Because heat shock proteins (HSPs) have an important protective function against ischemia/anoxia in mammalian brain, the authors investigated the expression of Hsp72 and Hsc73 in the anoxia-surviving turtle brain. Unlike the mammalian brain, high levels of Hsp72 were found in the normoxic turtle brain. Hsp72 levels were significantly increased by 4 hours of anoxia, remained constant until 8 hours, and then decreased to baseline at 12 hours. By contrast, Hsc73 was progressively increased throughout 12 hours of anoxia. This differential expression suggests different protective roles: Hsp72 in the initial downregulatory transition phase, and Hsc73 in maintaining neural network integrity during the long-term hypometabolic phase.
Prentice
Howard M
HM
Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA. hprentic@fau.edu
Milton
Sarah L
SL
Scheurle
Daniela
D
Lutz
Peter L
PL
D000818:Animals; D001923:Brain Chemistry; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000032:analysis*; D000860:Hypoxia / Q000378:metabolism*; D013997:Time Factors; D014426:Turtles
D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins