title: High in-plane resolution T2-weighted magnetic resonance imaging of acute myocardial ischemia in pigs using the intravascular contrast agent NC100150 injection.
abstract: OBJECTIVE
  The intravascular contrast agent NC100150 injection was tested for its ability to demarcate nonperfused myocardium in a porcine model of coronary occlusion.
  
  
  METHODS
  A T2-weighted fast spin echo sequence was acquired ex vivo and in vivo during first pass and steady-state circulation of the contrast agent in 2 dosages (2 and 5 mg Fe/kg bw) or saline.
  
  
  RESULTS
  Ex vivo, in the high-dose group, the volume of nonperfused myocardium determined from T2-weighted images was 99% of that determined from photographs where perfused myocardium stained with fluorescein. A significantly higher contrast to noise ratio between perfused and nonperfused myocardium was found (both ex and in vivo in steady state) compared with the control group. During first pass, a significant reduction in signal intensity (74 +/- 18%) was found in perfused myocardium after contrast injection.
  
  
  CONCLUSIONS
  NC100150 injection, combined with T2-weighted turbo spin echo imaging, allowed detailed visualization of non-perfused myocardium in the steady state, which corresponded to the area at risk as determined by fluorescein.
authors.affiliation: Department of Radiology, University Hospital, Uppsala, Sweden. Tomas.Bjerner@radiol.uu.se
authors.forename: Tomas
authors.initials: T
authors.lastname: Bjerner
authors.forename: Gerhard
authors.initials: G
authors.lastname: Wikström
authors.forename: Lars
authors.initials: L
authors.lastname: Johansson
authors.forename: Håkan
authors.initials: H
authors.lastname: Ahlström
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D003326:Coronary Circulation; D003911:Dextrans; D052203:Ferrosoferric Oxide; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D010087:Oxides / Q000008:administration & dosage; D013552:Swine
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide