title: Intentional partial coil occlusion followed by delayed clip application to wide-necked middle cerebral artery aneurysms in patients presenting with severe vasospasm. Report of two cases.
abstract: The treatment of ruptured cerebral aneurysms in patients presenting with vasospasm remains a particular challenge. The authors treated two patients harboring Hunt and Hess Grade 1 subarachnoid hemorrhages from middle cerebral artery (MCA) aneurysms associated with severe local angiographically demonstrated yet asymptomatic vasospasm on presentation. Because both aneurysms had wide necks and were located at the MCA bifurcation, they were believed to be anatomically suitable for microsurgical clip application. Severe M, vasospasm was believed to be a relative contraindication to open surgery, however. An intentionally staged endovascular and microsurgical treatment strategy was planned in each patient. Partial coil occlusion of the aneurysmal dome was performed to prevent the lesion from rebleeding and was followed by balloon angioplasty of the spastic vessel. Early treatment of the severe spasm appeared to prevent significant delayed neurological ischemic deficit. Following resolution of the vasospasm, definitive clipping of the aneurysms was performed on Day 13 post embolization. One patient had a good clinical recovery and was discharged without neurological deficit. The other patient's hospital course was complicated by the occurrence of a postoperative posterior temporal infarct requiring partial temporal lobectomy, although she eventually had a good recovery with only a small visual field deficit. Based on data obtained in these two patients, one can infer that ruptured wide-necked MCA aneurysms associated with severe local vasospasm may best be treated using a staged combined treatment plan. Delayed clip application might be performed more safely 4 to 6 weeks postocclusion, or later, than at 2 weeks.
authors.affiliation: Center for Endovascular Surgery, Department of Neurosurger, Hyman-Newman Institute for Neurology and Neurosurgery, Beth Israel Medical Center, New York, New York 10128, USA. JBrisman@chpnet.org
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Brisman
authors.forename: Chan
authors.initials: C
authors.lastname: Roonprapunt
authors.forename: Joon K
authors.initials: JK
authors.lastname: Song
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Niimi
authors.forename: Avi
authors.initials: A
authors.lastname: Setton
authors.forename: Alejandro
authors.initials: A
authors.lastname: Berenstein
authors.forename: Eugene S
authors.initials: ES
authors.lastname: Flamm
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000150:complications / Q000628:therapy*; D000800:Angioplasty, Balloon / Q000379:methods*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000628:therapy*; D008866:Microsurgery / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000628:therapy*