Targeting cytotoxic T lymphocytes for cancer immunotherapy.
In light of their preeminent role in cellular immunity, there is considerable interest in targeting of cytotoxic T-lymphocytes to cancer. This review summarises the active and passive immunotherapeutic approaches under development to achieve this goal, emphasising how recent advances in tumour immunology and gene transfer have impacted upon this field.
Maher
J
J
Cancer Research UK Breast Cancer Biology Group, Division of Cancer Studies, Guy's King's and St Thomas's School of Medicine, Guy's Hospital, St Thomas Street, London SE1 9RT, UK.
Davies
E T
ET
D018014:Gene Transfer Techniques; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*