title: Antioxidant tolerance of kidney after irradiation.
abstract: Different doses of irradiation were performed in which group 1 (non-irradiated), group 2 (8 Gy/single dose/whole body) and group 3 (15 Gy/single dose/whole body) were formed of guinea pigs. After 24 hr of radiation exposure the levels of lipid peroxidation product, malondialdehyde, (MDA), glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in the whole kidney. The MDA content increased in animals irradiated with 8 and 15 Gy. And group 3 showed an increase the level of MDA. GSH contents of kidney in group 2 and 3 increased. The activity of SOD decreased markedly in group 3 when compared with control group. The activity of GSH-Px decreased significantly in group 2 and group 3 in comparison to controls. It may be concluded that a high dose of ionizing irradiation cause excessive oxidative stress in kidney.
authors.affiliation: Department of Biochemistry, Medical Faculty, Gazi University, Ankara, Turkey. nbukan@yahoo.com
authors.forename: Neslihan
authors.initials: N
authors.lastname: Bukan
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Güney
authors.forename: Ayşe
authors.initials: A
authors.lastname: Hiçsönmez
authors.forename: Ayşe
authors.initials: A
authors.lastname: Bilgihan
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects / Q000528:radiation effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D008315:Malondialdehyde / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D005978:Glutathione