Going the distance, or not, with neurotrophin signals.
NGF and NT-3 both signal through TrkA receptors on the axons of developing sympathetic neurons, but while NGF supports survival and differentiation, NT-3 does not. In this issue of Cell, the difference is explained as the ability of NGF, but not NT-3, to induce internalization and retrograde transport of activated TrkA.
Reichardt
Louis F
LF
Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, 1550 Fourth Street, Room 284A, San Francisco, CA 94143, USA.
Mobley
William C
WC
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism*; D009420:Nervous System / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D020933:Neurotrophin 3 / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding / Q000502:physiology; D020917:Receptor, trkA; D015398:Signal Transduction / Q000502:physiology
D002352:Carrier Proteins; D008565:Membrane Proteins; D020933:Neurotrophin 3; D020932:Nerve Growth Factor; D020917:Receptor, trkA