Toll-like receptors and microbes take aim at each other.
Toll-like receptors (TLRs) are key components of effective innate immunity. As such, pathogenic microorganisms must evade recognition by TLRs, manipulate the consequences of TLR activation, or contend with the inflammatory consequences of TLR activation. Recent studies have improved our understanding of the various mechanisms by which pathogenic organisms manipulate the TLR recognition system.
Underhill
David M
DM
Institute for Systems Biology, 1441 N. 34th St, Seattle, Washington 98103, USA. dunderhill@systemsbiology.org
D000818:Animals; D001419:Bacteria / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D001426:Bacterial Proteins / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology*; D005656:Fungal Proteins / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D011956:Receptors, Cell Surface / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors
D001426:Bacterial Proteins; D005656:Fungal Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors