title: Semaphorins guide PerPlexeD endothelial cells.
abstract: Abrogation of the endothelial cell-specific semaphorin receptor PlexinD1 in zebrafish and mouse reveals semaphorin functions selectively affecting the cardiovascular system. Neuropilins team up with PlexinD1 to form a novel endothelial receptor complex for class 3 semaphorins.
authors.affiliation: Theodor-Kocher-Institute, University of Berne, Freiestrasse 1, 3012 Berne, Switzerland.
authors.forename: Urban
authors.initials: U
authors.lastname: Deutsch
mesh_terms: D000818:Animals; D018376:Cardiovascular Abnormalities / Q000235:genetics / Q000378:metabolism; D002319:Cardiovascular System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000002:abnormalities* / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000172:deficiency* / Q000235:genetics; D023421:Models, Animal; D009419:Nerve Tissue Proteins / Q000172:deficiency* / Q000235:genetics; D039921:Neuropilins / Q000378:metabolism; D039961:Semaphorins / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D039921:Neuropilins; C473552:Plxnd1 protein, mouse; D039961:Semaphorins