title: Prevalence of congenital hypothyroidism in Isfahan, Iran: results of a survey on 20,000 neonates.
abstract: OBJECTIVE
  To evaluate the prevalence of congenital hypothyroidism (CH) in a screening program performed for the first time in Isfahan, Iran.
  
  
  METHODS
  From May 2002 to December 2002, T4 and TSH serum concentrations of 20,000 3- to 7-day-old newborns, born in all 17 hospitals of the city, were measured by radioimmunoassay and immunoradiometric assay, respectively. The newborns with abnormal screening results (TSH >20 mIU/l, T4 <6.5 microg/dl and based on the weight) were re-examined.
  
  
  RESULTS
  Of 531 recalled subjects (recall rate 2.6%), 54 were confirmed to be hypothyroid, showing a prevalence of 1:370 for CH.
  
  
  CONCLUSIONS
  Considering the high frequency of CH, the necessity of implementing a routine screening program in the healthcare system of Isfahan Province is emphasized.
authors.affiliation: Isfahan Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences & Health Services, Isfahan, Iran. emrc@mui.ac.ir
authors.forename: Mahin
authors.initials: M
authors.lastname: Hashemipour
authors.forename: Massoud
authors.initials: M
authors.lastname: Amini
authors.forename: Ramin
authors.initials: R
authors.lastname: Iranpour
authors.forename: Gholam Hossein
authors.initials: GH
authors.lastname: Sadri
authors.forename: Narges
authors.initials: N
authors.lastname: Javaheri
authors.forename: Sassan
authors.initials: S
authors.lastname: Haghighi
authors.forename: Silva
authors.initials: S
authors.lastname: Hovsepian
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Javadi
authors.forename: Mahdi
authors.initials: M
authors.lastname: Nematbakhsh
authors.forename: Goshtasb
authors.initials: G
authors.lastname: Sattari
mesh_terms: D003409:Congenital Hypothyroidism; D003241:Consanguinity; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology*; D007231:Infant, Newborn; D007492:Iran / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D015995:Prevalence; D011795:Surveys and Questionnaires; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D013972:Thyrotropin; D013974:Thyroxine