Captopril-induced bilateral parotid and submandibular sialadenitis.
Two cases of sialadenitis following treatment with captopril are described. In case 1, an upper chest and facial erythema and dryness of the mouth accompanied the swelling of the salivary glands. In case 2, a conjunctival erythema accompanied the sialadenitis. None of the patients had previously used captopril, and, in both cases, the swelling occurred within the first hour after the drug intake; the patients had a complete recovery within a few hours after captopril was withdrawn. It is possible that the reported effect was caused by a type-B idiosyncratic adverse drug reaction.
Gislon Da Silva
Rafael Mariano
RM
Hospital São Vicente de Paulo, Faculdade de Medicina de Jundiaí, Jundiaí, São Paulo, Brazil. rafaelmarianogislon@hotmail.com
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D002216:Captopril / Q000009:adverse effects*; D005260:Female; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000139:chemically induced* / Q000473:pathology; D012793:Sialadenitis / Q000139:chemically induced* / Q000473:pathology; D013364:Submandibular Gland Diseases / Q000139:chemically induced* / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril