[Validation of the Diagnostic Interview for Genetic Studies (DIGS) in Colombia].
An interview tool, Diagnostic Interview for Genetic Studies (DIGS 3.0), was translated into Spanish for application in studies of psychiatric disorders in Colombia. Two Spanish translations of the original English version of DIGS were prepared and back-translated into English. A review committee verified the linguistic and cultural equivalence of the translations. The evaluator and test-retest reliability were assessed calculating Cohen's kappa for samples of 65 and 91 patients respectively. DIGS proved valid in both appearance and content. The confidence interval (C.I.) was excellent for schizophrenia (kappa = 0.81, C.I. 95% = 0.68-0.93), bipolar disorder (kappa = 0.87, C.I. 95% = 0.75-0.99), major depressive disorder (kappa = 0.86, C.I. 95% = 0.70-1.00), and for a normal diagnosis (kappa = 0.65, C.I. 95% = 0.41-0.89); it was good for other psychiatric diagnosis (kappa = 0.65, C.I. 95% = 0.41-0.89) and poor for schizoaffective disorder (kappa = 0.37, C.I. 95% = -0.02-0.76). Test-retest reliability was excellent for all diagnoses (kappa > 0.8), except for "other psychiatric diagnoses" (kappa = 0.64, C.I. 95% = 0.31-0.96). The Spanish translation of the DIGS was comprehensible, with face and content validity, and good test-retest and evaluator reliability. This translation will be a useful tool for genetic studies of psychiatric disorders in Latin America, particularly where schizophrenia and affective disorders are involved.
Palacio
Carlos Alberto
CA
Programa de Investigación en Psiquiatría Genética, Departamento de Psiquiatría y Laboratorio de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
García
Jenny
J
Arbeláez
María Patricia
MP
Sánchez
Ricardo
R
Aguirre
Beatriz
B
Garcés
Isabel Cristina
IC
Montoya
Gabriel Jaime
GJ
Gómez
Juliana
J
Agudelo
Angela
A
López
Carlos Alberto
CA
Calle
Jorge Julián
JJ
Cardeño
Carlos Alberto
CA
Cano
Juan Fernando
JF
López
María Cecilia
MC
Montoya
Patricia
P
Herrera
Claudia Patricia
CP
González
Natalia
N
González
Alejandro
A
Bedoya
Gabriel
G
Ruiz
Andrés
A
Ospina
Jorge
J
D003105:Colombia; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D007802:Language; D001523:Mental Disorders / Q000175:diagnosis* / Q000235:genetics; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D015203:Reproducibility of Results; D014175:Translating