title: Iridium complex-catalyzed highly enantio- and diastereoselective [2+2+2] cycloaddition for the synthesis of axially chiral teraryl compounds.
abstract: An asymmetric [2+2+2] cycloaddition of an alpha,omega-diyne, possessing ortho-substituted aryl groups on its terminus, and a monoalkyne with oxygen functionalities gave various axially chiral teraryl compounds. The coupling proceeded with extremely high enantio- (>99.5% ee) and diastereoselectivities (dl/meso = >95/5) when catalyzed by an iridium-chiral phosphine complex. As the products were readily transformed into diol compounds by deprotection without racemization, the present procedure provides access to a new chiral pool of diol compounds with C2 symmetry.
authors.affiliation: Department of Chemistry, School of Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555, Japan. tshibata@waseda.jp
authors.forename: Takanori
authors.initials: T
authors.lastname: Shibata
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Yokota
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takagi