The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages.
Autism is a neurodevelopmental disorder characterized by impairments in reciprocal social interaction, deficits in verbal and nonverbal communication, and a restricted repertoire of activities or interests. We performed a magnetic resonance imaging study to better define the neuropathology of autistic spectrum disorders. Here we report findings on the amygdala and the hippocampal formation. Borders of the amygdala, hippocampus, and cerebrum were defined, and their volumes were measured in male children (7.5-18.5 years of age) in four diagnostic groups: autism with mental retardation, autism without mental retardation, Asperger syndrome, and age-matched typically developing controls. Although there were no differences between groups in terms of total cerebral volume, children with autism (7.5-12.5 years of age) had larger right and left amygdala volumes than control children. There were no differences in amygdala volume between the adolescent groups (12.75-18.5 years of age). Interestingly, the amygdala in typically developing children increases substantially in volume from 7.5 to 18.5 years of age. Thus, the amygdala in children with autism is initially larger, but does not undergo the age-related increase observed in typically developing children. Children with autism, with and without mental retardation, also had a larger right hippocampal volume than typically developing controls, even after controlling for total cerebral volume. Children with autism but without mental retardation also had a larger left hippocampal volume relative to controls. These cross-sectional findings indicate an abnormal program of early amygdala development in autism and an abnormal pattern of hippocampal development that persists through adolescence. The cause of amygdala and hippocampal abnormalities in autism is currently unknown.
Schumann
Cynthia Mills
CM
Department of Psychiatry and Behavioral Sciences, Center for Neuroscience and the M.I.N.D. (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Sacramento, California 95817, USA.
Hamstra
Julia
J
Goodlin-Jones
Beth L
BL
Lotspeich
Linda J
LJ
Kwon
Hower
H
Buonocore
Michael H
MH
Lammers
Cathy R
CR
Reiss
Allan L
AL
Amaral
David G
DG
D000293:Adolescent; D000367:Age Factors; D000679:Amygdala / Q000473:pathology*; D001321:Autistic Disorder / Q000150:complications / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002648:Child; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D008607:Intellectual Disability / Q000150:complications / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size