Infectious and inflammatory mechanisms in preterm birth and cerebral palsy.
OBJECTIVE
In a thesis examine infectious and inflammatory mechanisms involved in preterm birth and cerebral palsy.


METHODS
Four cross-sectional studies and a case control study.


RESULTS
Microbial invasion of the amniotic cavity and inflammation in this population of Swedish women in preterm labor and preterm prelabor rupture of membranes was similar to that reported in data from populations with a higher incidence of preterm birth. Our data support an association between antenatal infection/inflammation and cerebral palsy.


CONCLUSIONS
Infectious and inflammatory mechanisms are involved in preterm birth and cerebral palsy in a population with low incidence of preterm birth.
Jacobsson
Bo
B
Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, The Sahlgrenska Academy at Göteborg University, SE-41685, Sweden. bo.jacobsson@obgyn.gu.se
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000276:immunology; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000276:immunology*; D002821:Chorioamnionitis / Q000276:immunology / Q000382:microbiology; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000032:analysis; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000276:immunology*; D007752:Obstetric Labor, Premature / Q000276:immunology / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000382:microbiology; D013548:Sweden
D016207:Cytokines