Innovative approaches to lung volume reduction for emphysema.
The 10 years of resurgent interest in lung volume reduction surgery (LVRS) and recent National Emphysema Treatment Trial findings for emphysema have stimulated a range of innovative alternative ideas aimed at improving outcomes and reducing complications associated with current LVRS techniques. Concepts being actively investigated at this time include surgical resection with compression/banding devices, endobronchial blockers, sealants, obstructing devices and valves, and bronchial bypass methods. These novel approaches are reaching the stage of clinical trials at this time. Theory, design issues, methods, potential advantages and limitations, and available results are presented. Extensive research in the near future will help to determine the potential clinical applicability of these new approaches to the treatment of emphysema symptoms.
Brenner
Matt
M
Division of Pulmonary Medicine and Beckman Laser Institute, University of California Irvine Medical Center, Orange, 92868, USA. mbrenner@uci.edu
Hanna
Nevine Mikhail
NM
Mina-Araghi
Reza
R
Gelb
Arthur F
AF
McKenna
Robert J
RJ
Colt
Henri
H
D000818:Animals; D004646:Emphysema / Q000601:surgery*; D006801:Humans; D011013:Pneumonectomy / Q000295:instrumentation / Q000379:methods / Q000639:trends; D013525:Surgical Instruments; D016896:Treatment Outcome