Effect of sildenafil citrate on retinal functions: preliminary report on Humphrey visual field analysis.
OBJECTIVE
To assess the effect of sildenafil citrate treatment on visual field analysis (VFA) in patients using sildenafil citrate for erectile dysfunction.


METHODS
In this prospective study on 18 male volunteers with erectile dysfunction, bilateral VFA was performed using the Humphrey 30-2 central standard threshold test. White-on-white (W/W) and blue-on-yellow (B/Y) protocols were used prior to treatment (baseline VFA) and after treatment (repeat VFA) with sildenafil citrate. W/W and B/Y baseline VFA and repeat VFA mean deviations (MD) were compared.


RESULTS
The baseline MD for W/W and B/Y protocols were -1.34 +/- 1.8 and -2.59 +/- 2.1 dB, respectively, whereas the mean repeat MD for W/W and B/Y protocols were -1.79 +/- 2.21 and -2.83 +/- 3.31 dB, respectively. There was no statistically significant difference between W/W and B/Y baseline and repeat VFA with respect to MD (p > 0.05).


CONCLUSIONS
Sildenafil citrate causes no significant changes in Humphrey VFA in patients with erectile dysfunction.
Oner
Hakan F
HF
Department of Ophthalmology, Dokuz Eylül University School of Medicine, Izmir, Turkey.
Aslan
Güven
G
Kurtulan
Erkan
E
Uçar
Tolga
T
Saatçi
Osman A
OA
Esen
Adil A
AA
D000328:Adult; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use; D011446:Prospective Studies; D011687:Purines; D012160:Retina / Q000187:drug effects*; D000068677:Sildenafil Citrate; D013450:Sulfones; D014787:Vision Tests / Q000379:methods; D014794:Visual Fields / Q000187:drug effects
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate