[Phosphotyrosine phosphatase SHP-1, somatostatin and prostate cancer].
We review the mechanisms involved in prostatic growth based on androgens and product of neuroendocrine secretion, with special reference to the role of somatostatin (SS) in the inhibition of neoplastic growth. Our contributions in the field confirm the antiproliferative effect of SS on the prostate is mediated by phosphotyrosine phosphatase SHP-1, that is present in human prostate. This enzyme plays a role in the control of prostatic cell proliferation and in the progression of prostate cancer. Besides, we consider its presence may determine the therapeutic potential of SS in the control of prostate cancer.
Zapata
P D
PD
Departamento de Bioquímica, Universidad de Alcalá, Servicio de Urología, Hospital Príncipe de Asturias, Alcalá de Henares, Madrid.
Colas
B
B
López-Ruiz
P
P
Ropero
R M
RM
Martín
R M
RM
Rodríguez
F J
FJ
González
F J
FJ
López
J I
JI
Angulo
J C
JC
D035843:Biomedical Research; D002455:Cell Division; D018450:Disease Progression; D005544:Forecasting; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009490:Neurosecretory Systems / Q000166:cytology; D011467:Prostate / Q000254:growth & development; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000473:pathology; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000502:physiology*; D013004:Somatostatin / Q000502:physiology*
D047908:Intracellular Signaling Peptides and Proteins; D013004:Somatostatin; C509249:PTPN6 protein, human; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases