title: Fine-needle aspiration biopsy: use in diagnosis and management of pediatric thyroid diseases.
abstract: Fine-needle aspiration (FNA) biopsy of the thyroid is a reliable, safe, cost-effective, and widely used test. Its introduction and application have had a significant impact in the management of nodular thyroid diseases in adults. However, its utility in pediatric practice is not recognized or emphasized. During the last 12 years we performed 10,971 FNAs; 57 (0.5%) were in patients younger than age 17 years. Among 47 of these biopsies, 66% were benign, 15% were malignant, 6% were suspicious for malignancy and 13% were nondiagnostic. Biopsy was most often (96%) performed for the evaluation of diffuse or nodular goiter. The most common benign cytologic diagnosis was colloid goiter in 17 of 31 patients (55%) and Hashimoto's thyroiditis in 9 of 31 patients (29%). There were no false-positive results and there was one false-negative cytologic result. Among patients who had malignancy proved histologically, nine patients (75%) had papillary thyroid cancer. In this study, FNA biopsy was crucial in deferring surgery in 28 of 47 patients (60%). It is clear that the application of FNA biopsy prevents unnecessary surgery and improves surgical selection of patients with thyroid malignancy. On the basis of our extensive experience, we recommend FNA biopsy as the first diagnostic test for pediatric patients with nodular thyroid lesions.
authors.affiliation: The Division of Endocrinology, Metabolism, and Internal Medicine, Department of Pediatrics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
authors.forename: H
authors.initials: H
authors.lastname: Gharib
authors.forename: D
authors.initials: D
authors.lastname: Zimmerman
authors.forename: J R
authors.initials: JR
authors.lastname: Goellner
authors.forename: S M
authors.initials: SM
authors.lastname: Bridley
authors.forename: S M
authors.initials: SM
authors.lastname: LeBlanc