title: Low serum triiodothyronine in acute myocardial infarction indicates major heart injury.
abstract: OBJECTIVE
  In patients with acute myocardial infarction (MI), low serum triiodothyronine (T3) concentration is commonly associated with a severe clinical course. The aim of this prospective study was to investigate whether a severe clinical course in patients with low T3 is related to the magnitude of myocardial injury assessed by echocardiography.
  
  
  RESULTS
  Out of 635 patients with MI we enrolled 100 consecutive patients. They were divided in two subgroups: group A, 81 patients without clinical hard events (death, resuscitation following ventricular tachycardia/vertricular fibrillation, new MI) and group B, 19 patients in whom at least one of the above hard events occurred during hospital stay. Thyroid function tests were performed on day 1, 4 and 7, echocardiographic examinations measuring asynergic area (AA), and wall motion score index (WMSI) between day 1 and 5 (median 3). A negative correlation was found between plasma free triiodothyronine (FT3), concentration and AA (p<0.001), FT3 and WMSI (p<0.001) values at all time points. FT3 concentration was lower in group B than group A at all time points (p<0.001).
  
  
  CONCLUSIONS
  In patients with acute MI, low FT3 state is related to the extent of myocardial damage.
authors.affiliation: Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Ceremuzyński
authors.forename: Aleksander
authors.initials: A
authors.lastname: Górecki
authors.forename: Leszek
authors.initials: L
authors.lastname: Czerwosz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Chamiec
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Bartoszewicz
authors.forename: Krystyna
authors.initials: K
authors.lastname: Herbaczyńska-Cedro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D013961:Thyroid Gland / Q000503:physiopathology*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D015415:Biomarkers; D014284:Triiodothyronine