title: Assessing acute middle cerebral artery ischemic stroke by quantitative electric tomography.
abstract: This paper focuses on the application of quantitative electric tomography (qEEGT) to map changes in EEG generators for detection of early signs of ischemia in patients with acute middle cerebral artery stroke. Thirty-two patients were studied with the diagnosis of acute ischemic stroke of the left middle cerebral artery territory, within the first 24 hours of their clinical evolution. Variable Resolution Electrical Tomography was used for estimating EEG source generators. High resolution source Z-spectra and 3- dimensional images of Z values for all the sources at each frequency were obtained for all cases. To estimate statistically significant increments and decrements of brain electric activity within the frequency spectra, the t-Student vs. Zero test was performed. A significant increment of delta activity was observed on the affected vascular territory, and a more extensive increment of theta activity was detected. A significant alpha decrement was found in the parieto-occipital region of the affected cerebral hemisphere (left), and in the medial and posterior region of the right hemisphere. These findings suggest that qEEGT Z delta images are probably related to the main ischemic core within the affected arterial territory; penumbra, diaschisis, edema, might explain those observed theta and alpha abnormalities. It was concluded that qEEGT is useful for the detection of early signs of ischemia in acute ischemic stroke.
authors.affiliation: Institute of Neurology and Neurosurgery, Havana, Cuba. braind@infomed.sld.cu
authors.forename: Calixto
authors.initials: C
authors.lastname: Machado
authors.forename: Elena
authors.initials: E
authors.lastname: Cuspineda
authors.forename: Pedro
authors.initials: P
authors.lastname: Valdés
authors.forename: Trinidad
authors.initials: T
authors.lastname: Virues
authors.forename: Francis
authors.initials: F
authors.lastname: Llopis
authors.forename: Jorge
authors.initials: J
authors.lastname: Bosch
authors.forename: Eduardo
authors.initials: E
authors.lastname: Aubert
authors.forename: Eraida
authors.initials: E
authors.lastname: Hernández
authors.forename: Alejandro
authors.initials: A
authors.lastname: Pando
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Alvarez
authors.forename: Esperanza
authors.initials: E
authors.lastname: Barroso
authors.forename: Lídice
authors.initials: L
authors.lastname: Galán
authors.forename: Yoel
authors.initials: Y
authors.lastname: Avila
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000513:Alpha Rhythm; D001929:Brain Edema / Q000473:pathology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013826:Theta Rhythm