Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria.
Heme oxygenase (HO) is thought to be induced in severe malaria, but the pathophysiologic consequences have not been examined. It is induced by hemolysis, oxidative stress, and inflammation. It degrades heme, producing carbon monoxide (CO), which causes elevated levels of carboxyhemoglobin (COHb). In a prospective study of 1,520 children admitted to a Kenyan district hospital, COHb levels were no higher in children with malaria than with other infections. The COHb levels in children with severe malarial anemia were higher than in other children with malaria, but significantly lower than in children with other causes of severe anemia such as sickle cell disease. Levels of COHb were not significantly higher in children with cerebral malaria or in those dying of malaria. These results do not support a systemic increase in HO activity in malaria compared with other infectious diseases, but the roles of HO and CO in malaria require further study.
Cunnington
Aubrey J
AJ
Department of Paediatrics, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom. acunning@doctors.org.uk
Kendrick
Stuart F W
SF
Wamola
Betty
B
Lowe
Brett
B
Newton
Charles R J C
CR
D000740:Anemia / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D002263:Carboxyhemoglobin / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007630:Kenya / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000150:complications / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011446:Prospective Studies
D002263:Carboxyhemoglobin