Proteolytic activity in Serratia marcescens clinical isolates.
Exoproteinase production was demonstrated in 64 clinical isolates of S. marcescens. A significant relationship was found between the site of origin (autopsy material, hemocultures, various other sources), proteinase activity, and LD50 of the analyzed isolates. The number of exoproteinases varied during a 14-h incubation in batch cultures; the most frequently found was a 57.5-kDa proteinase which was observed in all analyzed strains. The exoproteinase production was shown to be related to strain virulence.
Coria-Jiménez
R
R
Laboratory of Experimental Bacteriology, National Institute of Pediatrics, México City, 04530 México. rafaelcoria@yahoo.com
Zárate-Aquino
C
C
Ponce-Ponce
O
O
D020689:Exopeptidases / Q000378:metabolism*; D006801:Humans; D012706:Serratia marcescens / Q000201:enzymology* / Q000472:pathogenicity* / Q000502:physiology; D014774:Virulence
D020689:Exopeptidases