[Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine].
The paper presents a review of the scientific publications on Rhodiola rosea L. known for its adaptogenic characteristics. Biologically active substances salidroside, rosin, rosavin, rosarin and tyrosol, which are mainly found in plant rhizomes, demonstrate therapeutic effect. These active components effect the central nervous system by increasing the ability to concentrate, the mental and physical power; they are efficient in the asthenic states and improve general resistance of the cells and the organism against the harmful outer influence. They also prevent the heart system from stress and arrhythmias, and posses some antioxidant activity. Some data confirm that the Rhodiola rosea L. preparations stop the growth of the malignant tumors and metastases in the liver. Some preclinical and clinical data of the golden root preparations are discussed in the survey. The interaction of the herb with other medicines, its usage and effect, recommended doses, and its side effects are also reviewed in the paper.
Kucinskaite
Agne
A
Department of Pharmaceutical Technology and Pharmacy Organization, Kaunas University of Medicine, A. Mickeviciaus 9, 44307 Kaunas, Lithuania. agnute.ku@delfi.lt
Briedis
Vitalis
V
Savickas
Arūnas
A
D000222:Adaptation, Physiological / Q000187:drug effects; D000328:Adult; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000975:Antioxidants; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002490:Central Nervous System / Q000187:drug effects; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008195:Lymnaea / Q000187:drug effects; D008519:Medicine, Traditional; D005222:Mental Fatigue / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012116:Resins, Plant; D029771:Rhodiola
D000889:Anti-Arrhythmia Agents; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; D028321:Plant Preparations; D012116:Resins, Plant; C011867:4-hydroxyphenylethanol; C013893:rosin; C009172:rhodioloside; D010626:Phenylethyl Alcohol