Mortality in Parkinson's disease and its association with dementia and depression.
OBJECTIVE
To compare the mortality rate in Parkinson's disease (PD) with a control group without PD, and to assess the relationship between mortality and features of PD.


METHODS
Ninety PD patients and 50 controls, mortality ascertained at 11 years follow-up.


RESULTS
The hazard ratio (HR) for mortality in PD patients compared with controls was 1.64 (95% CI: 1.21-2.23). Multivariate analysis showed age, dementia and depression were independent predictors of mortality but age at onset of PD and severity of neurological symptoms were not. The HR for age was 1.09 (95% CI: 1.05-1.13), for dementia 1.94 (95% CI: 1.26-2.99), and for depression 2.66 (95% CI: 1.59-4.44).


CONCLUSIONS
Mortality in PD is increased compared with controls. Psychological variables are important predictors of mortality in PD.
Hughes
T A
TA
Academic Unit of Psychiatry and Behavioural Sciences, University of Leeds, Leeds, UK. tom.hughes@leedsmh.nhs.uk
Ross
H F
HF
Mindham
R H S
RH
Spokes
E G S
EG
D000368:Aged; D016022:Case-Control Studies; D003704:Dementia / Q000175:diagnosis / Q000209:etiology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000401:mortality* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D015996:Survival Rate