title: The role of adenosine-related genes variants in susceptibility to essential hypertension.
abstract: OBJECTIVE
  To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH).
  
  
  METHODS
  Case-control association study investigating gene variants for the ADORA1, ADORA2a and ADA genes.
  
  
  METHODS
  The study used a cohort of 249 unrelated hypertensive individuals who were diagnosed with hypertension, and an age, sex and ethnically matched group of 249 normotensive controls.
  
  
  RESULTS
  The association analysis indicated that both allele and genotype frequencies did not differ significantly between the case and control groups (P > 0.05) for any of the markers tested.
  
  
  CONCLUSIONS
  The adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives. However, involvement of these genes and the adenosine system cannot be conclusively excluded from essential hypertension pathogenesis as other gene variants may still be involved.
authors.affiliation: Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia.
authors.forename: Kirsty
authors.initials: K
authors.lastname: Wright
authors.forename: Lotti
authors.initials: L
authors.lastname: Tajouri
authors.forename: Rod A
authors.initials: RA
authors.lastname: Lea
authors.forename: Micky
authors.initials: M
authors.lastname: Ovcaric
authors.forename: Stephanie
authors.initials: S
authors.lastname: Heux
authors.forename: Fabien
authors.initials: F
authors.lastname: Morin
authors.forename: Wallid
authors.initials: W
authors.lastname: Bey
authors.forename: John P
authors.initials: JP
authors.lastname: Headrick
authors.forename: Lyn R
authors.initials: LR
authors.lastname: Griffiths
mesh_terms: D000241:Adenosine / Q000235:genetics; D000243:Adenosine Deaminase / Q000235:genetics*; D000368:Aged; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D043682:Receptor, Adenosine A1 / Q000235:genetics*; D043705:Receptor, Adenosine A2A / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D043682:Receptor, Adenosine A1; D043705:Receptor, Adenosine A2A; D000243:Adenosine Deaminase; D000241:Adenosine