The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer.
The relationship between tumour stage, T-lymphocyte subset infiltration and survival was examined in patients with prostate cancer (n=80). On multivariate analysis PSA (HR 2.47, 95% CI 1.27-4.83, P=0.008) and CD4+ T-lymphocyte count (HR 2.29, 95% CI 1.25-4.22, P=0.008) had independent significance. Increased CD4+ T-lymphocyte infiltration within the tumour was stage independent and associated with poor outcome in patients with prostate cancer.
McArdle
P A
PA
University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK.
Canna
K
K
McMillan
D C
DC
McNicol
A-M
AM
Campbell
R
R
Underwood
M A
MA
D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011446:Prospective Studies; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000473:pathology* / Q000601:surgery; D016019:Survival Analysis; D013601:T-Lymphocytes / Q000502:physiology*