[Fixed drug eruption induced by sulfaguanidine].
BACKGROUND
Fixed drug eruption is a lesion induced by drugs. The family of drugs usually incriminated are sulfonamides, tetracyclines and pyrazols. We describe nine cases of fixed drug eruption induced by sulfaguanidine, a sulfonamide with local action.


METHODS
All the patients presented one or more fixed drug eruption reactivation lesions induced by sulfaguanidine as self-medication for diarrhea. The number of lesions increased in 7 cases after reactivation. The delay in occurrence of the fixed drug eruption decreased during the different episodes. The lesions predominated on the hands in 8 cases of 9.


CONCLUSIONS
The sulfaguanidine must be added to the list of drug-induced fixed drug eruptions with limited absorption from the gastrointestinal tract.
Kastalli
S
S
Centre National de Pharmacovigilance, Hôpital Charles Nicolle, Boulevard du 9 avril 1938, Tunis 1006, Tunisie.
El Aidli
S
S
Daghfous
R
R
Trabelsi
S
S
Lakhal
M
M
Loueslati
M-H
MH
Belkahia
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004890:Erythema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013414:Sulfaguanidine / Q000009:adverse effects*
D000890:Anti-Infective Agents; D013414:Sulfaguanidine