title: Aptamer-based sensor arrays for the detection and quantitation of proteins.
abstract: Aptamer biosensors have been immobilized on beads, introduced into micromachined chips on the electronic tongue sensor array, and used for the detection and quantitation of proteins. Aptamer chips could detect proteins in both capture and sandwich assay formats. Unlike most protein-based arrays, the aptamer chips could be stripped and reused multiple times. The aptamer chips proved to be useful for screening aptamers from in vitro selection experiments and for sensitively quantitating the biothreat agent ricin.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Romy
authors.initials: R
authors.lastname: Kirby
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Cho
authors.forename: Brian
authors.initials: B
authors.lastname: Gehrke
authors.forename: Travis
authors.initials: T
authors.lastname: Bayer
authors.forename: Yoon Sok
authors.initials: YS
authors.lastname: Park
authors.forename: Dean P
authors.initials: DP
authors.lastname: Neikirk
authors.forename: John T
authors.initials: JT
authors.lastname: McDevitt
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Ellington
mesh_terms: D001483:Base Sequence; D015374:Biosensing Techniques; D008969:Molecular Sequence Data; D009113:Muramidase / Q000378:metabolism; D009841:Oligonucleotides / Q000737:chemistry*; D040081:Protein Array Analysis / Q000379:methods*; D011506:Proteins / Q000032:analysis*; D012276:Ricin / Q000378:metabolism
chemical_list: D009841:Oligonucleotides; D011506:Proteins; D012276:Ricin; D009113:Muramidase