title: [Early diagnosis of leukaemia in the trisomic child. Congolese experience based on two cases].
abstract: We are reporting here two cases of acute leukemia in Congolese children with Down syndrome. They were aged 27 and 30 months. The two cases were revealed by anemia, hyperthermia with enlargement of the liver and the spleen. Clinical course was unfavorable. Therefore, the early diagnosis of leukemia remains very important in patient with Down syndrome presenting hyperthermia with hepatosplenomegaly.
authors.affiliation: Service de pédiatrie Nourrissons, CHU, Brazzaville, BP32, République du Congo.
authors.forename: A
authors.initials: A
authors.lastname: Mouko
authors.forename: F
authors.initials: F
authors.lastname: Nkanta-Etokabeka
authors.forename: P
authors.initials: P
authors.lastname: Senga
mesh_terms: D000740:Anemia / Q000209:etiology; D001797:Blood Protein Electrophoresis; D001856:Bone Marrow Examination; D002675:Child, Preschool; D003223:Congo; D004314:Down Syndrome / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D005334:Fever / Q000209:etiology; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D007964:Leukocytosis / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D011379:Prognosis; D012307:Risk Factors; D013163:Splenomegaly / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology; D013997:Time Factors