title: Evolution of dilated cardiomyopathy (DCM) from idiopathic hypertrophic cardiomyopathy (IHCM) vs. inflammatory dilated cardiomyopathy (DCMi): a rare case of sudden death in an 8-year-old boy.
abstract: In rare cases, the diagnosis of hypertrophic and dilated cardiomyopathy (DCM) in children was established postmortem. Our case report deals with the sudden and unexpected death of an 8-year-old boy. The postmortem examination revealed non-obstructive hypertrophy with irregular arrangement of muscular fibers, dilatation of the ventricles, endocardial fibrosis, microfocal vacuolization with enlarged hyperchromatic nuclei, and signs of inflammation with interstitial fibrosis. We present an evolution from idiopathic cardiomyopathy to DCM. To some extent, there were morphologic signs of an inflammatory process that first led us to suspect a specific inflammatory DCM.
authors.affiliation: Department of Forensic Medicine, University of Bonn, Stiftsplatz 12, Bonn D-53111, Germany. rdettmey@uni-bonn.de
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dettmeyer
authors.forename: Peter
authors.initials: P
authors.lastname: Schmidt
authors.forename: Reinhard
authors.initials: R
authors.lastname: Kandolf
authors.forename: Burkhard
authors.initials: B
authors.lastname: Madea
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000378:metabolism / Q000473:pathology*; D002312:Cardiomyopathy, Hypertrophic / Q000378:metabolism / Q000473:pathology*; D002648:Child; D016757:Death, Sudden, Cardiac / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology*; D008297:Male; D032342:Muscle Cells / Q000473:pathology