title: Three-dimensional proton spectroscopy of deep gray matter nuclei in relapsing-remitting MS.
abstract: The metabolic changes in the deep gray matter (GM) nuclei, thalamus, and basal ganglia of patients with relapsing-remitting multiple sclerosis were investigated with quantitative, multivoxel, three-dimensional proton MR spectroscopy. This technique facilitated the study of several bilateral structures in a single session at sub-cubic centimeter spatial resolution. Compared with 9 matched control subjects, the deep GM nuclei of 11 patients showed 7% lower N-acetylaspartate and 14% higher choline levels (p = 0.02 for both).
authors.affiliation: Department of Radiology, New York University School of Medicine, New York 10016, USA.
authors.forename: M
authors.initials: M
authors.lastname: Inglese
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: J S
authors.initials: JS
authors.lastname: Babb
authors.forename: L J
authors.initials: LJ
authors.lastname: Mannon
authors.forename: R I
authors.initials: RI
authors.lastname: Grossman
authors.forename: O
authors.initials: O
authors.lastname: Gonen
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D001479:Basal Ganglia / Q000737:chemistry / Q000473:pathology*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000378:metabolism / Q000473:pathology*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D013787:Thalamic Nuclei / Q000737:chemistry / Q000473:pathology*
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline