Immune evasion by gamma-herpesviruses.
Persistent viruses, such as herpesviruses, transmit infection by evading cytotoxic T cells during lytic replication. The gamma-herpesviruses additionally evade T cells during the proliferation of latently infected lymphocytes to establish a persistent viral reservoir. Lytic gene expression in sites of lymphoproliferation appears to make a vital contribution to this latent immune evasion. Lytic antigens may therefore be a key immune target. Investigations into a murine gamma-herpesvirus have now provided evidence that vaccination with apathogenic, latency-deficient mutants can largely protect against subsequent wild-type gamma-herpesvirus latency establishment.
Stevenson
Philip G
PG
University of Cambridge, Division of Virology, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK. pgs27@mole.bio.cam.ac.uk
D018142:Gammaherpesvirinae / Q000276:immunology* / Q000502:physiology; D015967:Gene Expression Regulation, Viral / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology; D017735:Virus Latency / Q000276:immunology*; D014779:Virus Replication / Q000276:immunology*
D014765:Viral Vaccines