Post-irradiation dietary vitamin E does not affect the development of radiation-induced lung damage in rats.
The purpose of this study was to investigate whether application of post-irradiation vitamin E, an anti-oxidant, could prevent the development of radiation induced lung damage. Wistar rats were given vitamin E enriched or vitamin E deprived food starting from 4 weeks after 18Gy single dose irradiation of the right thorax. Neither breathing frequencies nor CT density measurements revealed differences between the groups. It is concluded that post-irradiation vitamin E does not influence radiation-induced fibrosis to the lung.
Wiegman
Erwin M
EM
Department of Radiation Oncology, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
van Gameren
Mieke M
MM
Kampinga
Harm H
HH
Szabó
Ben G
BG
Coppes
Rob P
RP
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D017564:Radiation Pneumonitis / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013909:Thorax; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D000975:Antioxidants; D014810:Vitamin E