Low serum triiodothyronine in acute myocardial infarction indicates major heart injury.
OBJECTIVE
In patients with acute myocardial infarction (MI), low serum triiodothyronine (T3) concentration is commonly associated with a severe clinical course. The aim of this prospective study was to investigate whether a severe clinical course in patients with low T3 is related to the magnitude of myocardial injury assessed by echocardiography.


RESULTS
Out of 635 patients with MI we enrolled 100 consecutive patients. They were divided in two subgroups: group A, 81 patients without clinical hard events (death, resuscitation following ventricular tachycardia/vertricular fibrillation, new MI) and group B, 19 patients in whom at least one of the above hard events occurred during hospital stay. Thyroid function tests were performed on day 1, 4 and 7, echocardiographic examinations measuring asynergic area (AA), and wall motion score index (WMSI) between day 1 and 5 (median 3). A negative correlation was found between plasma free triiodothyronine (FT3), concentration and AA (p<0.001), FT3 and WMSI (p<0.001) values at all time points. FT3 concentration was lower in group B than group A at all time points (p<0.001).


CONCLUSIONS
In patients with acute MI, low FT3 state is related to the extent of myocardial damage.
Ceremuzyński
Leszek
L
Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.
Górecki
Aleksander
A
Czerwosz
Leszek
L
Chamiec
Tomasz
T
Bartoszewicz
Zbigniew
Z
Herbaczyńska-Cedro
Krystyna
K
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D013961:Thyroid Gland / Q000503:physiopathology*; D014284:Triiodothyronine / Q000097:blood*
D015415:Biomarkers; D014284:Triiodothyronine