Metabolic substrates of neuronal aging.
One mechanism proposed to explain age-dependent changes has been the "Ca(2+) hypothesis" of aging. Data indicate that most changes in the Ca(2+) homeostasis of the cerebellar granule neurons appear only when the aged neurons are exposed to higher levels of stimulation and that these changes are secondary to metabolic limitations imposed by altered mitochondrial function.
Toescu
E C
EC
Department of Physiology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. e.c.toescu@bham.ac.uk
Xiong
J
J
D000375:Aging; D000818:Animals; D001921:Brain / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors
D002118:Calcium