Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors.
Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.
Mantovani
Alberto
A
Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy. mantovani@marionegri.it
Allavena
Paola
P
Sozzani
Silvano
S
Vecchi
Annunciata
A
Locati
Massimo
M
Sica
Antonio
A
D018925:Chemokines / Q000502:physiology*; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism*
D018925:Chemokines