title: Ranitidine-enhanced 99mtechnetium pertechnetate imaging in children improves the sensitivity of identifying heterotopic gastric mucosa in Meckel's diverticulum.
abstract: Meckel's diverticulum is the most common congenital gastrointestinal anomaly. (99m )Technetium pertechnetate imaging (Meckel's scan) is the best noninvasive method used to diagnose this condition when heterotopic gastric mucosa (HGM) is present. Although cimetidine enhancement has been shown to improve sensitivity of the Meckel's scan, ranitidine enhancement has also been advocated; however, this recommendation is based on unpublished data. Thirty-seven children with confirmed Meckel's diverticulum were reviewed retrospectively. Of eight children with HGM in the Meckel's diverticulum who presented with profuse rectal bleeding and underwent the conventional Meckel's scan, three of them (37.5%) had a false negative study. Ranitidine, when administered either intravenously or orally for 24 h prior to the Meckel's scan, enhanced the sensitivity of this test to 87.5% in our patient cohort.
authors.affiliation: Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Melbourne, Flemington Road, 3052 Parkville, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Rerksuppaphol
authors.forename: J M
authors.initials: JM
authors.lastname: Hutson
authors.forename: M R
authors.initials: MR
authors.lastname: Oliver
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002828:Choristoma; D005260:Female; D005753:Gastric Mucosa; D006635:Histamine H2 Antagonists; D006801:Humans; D007077:Ileal Diseases / Q000000981:diagnostic imaging*; D007089:Image Enhancement; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008467:Meckel Diverticulum / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D011899:Ranitidine; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013670:Sodium Pertechnetate Tc 99m
chemical_list: D006635:Histamine H2 Antagonists; D019275:Radiopharmaceuticals; D011899:Ranitidine; D013670:Sodium Pertechnetate Tc 99m