Airway eicosanoids in acute severe respiratory syncytial virus bronchiolitis.
We prospectively studied the levels of eicosanoids in intubated patients with severe bronchiolitis and compared them to electively intubated non-infected infants. LeukotrieneE(4) (LTE(4)), leukotrieneB(4) (LTB(4)), and prostaglandinE(2) (PGE(2)) levels were significantly increased (P <.01) from endotracheal (ET) aspirates of infants with bronchiolitis compared with controls, as were urinary LTE(4) levels (P <.001). We conclude that eicosanoids are increased in the tracheal aspirates and urine of children with bronchiolitis.
Sznajer
Yves
Y
Pediatric Intensive Care Unit, Sainte-Justine Hospital, University of Montreal, Quebec, Canada.
Westcott
Jay Y
JY
Wenzel
Sally E
SE
Mazer
Bruce
B
Tucci
Marisa
M
Toledano
Baruch Joseph
BJ
D000208:Acute Disease; D001990:Bronchiolitis, Viral / Q000378:metabolism*; D016022:Case-Control Studies; D002675:Child, Preschool; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007442:Intubation, Intratracheal; D007975:Leukotriene B4 / Q000378:metabolism*; D017999:Leukotriene E4 / Q000378:metabolism*; D008297:Male; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000378:metabolism*
D007975:Leukotriene B4; D017999:Leukotriene E4; D015232:Dinoprostone