title: Shedding of human herpesvirus 8 in oral and genital secretions from HIV-1-seropositive and -seronegative Kenyan women.
abstract: Polymerase chain reaction was used to determine the prevalence and correlates of human herpesvirus 8 (HHV8) in saliva, mouth, cervical, vaginal, plasma, and peripheral-blood mononuclear cell (PBMC) samples from 174 HHV8-seropositive female prostitutes in Mombasa, Kenya. The prevalence of detection of HHV8 was 32% in saliva samples, 28% in mouth swabs, 4% in cervical swabs, 2.3% in vaginal swabs, 9% in plasma samples, and 18% in PBMC samples. Human immunodeficiency virus type 1 (HIV-1) seropositivity was associated with detection of HHV8 from any mucosal surface (odds ratio, 2.1 [95% confidence interval, 1.1-4.0]). In HIV-1-seropositive women, there was no association between detection of HHV8 and either CD4 count or HIV-1 viral load.
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington, USA. metaylor@dhs.co.la.ca.us
authors.forename: Melanie M
authors.initials: MM
authors.lastname: Taylor
authors.forename: Bhavna
authors.initials: B
authors.lastname: Chohan
authors.forename: Ludo
authors.initials: L
authors.lastname: Lavreys
authors.forename: Wisal
authors.initials: W
authors.lastname: Hassan
authors.forename: Meei-Li
authors.initials: ML
authors.lastname: Huang
authors.forename: Larry
authors.initials: L
authors.lastname: Corey
authors.forename: Rhoda
authors.initials: R
authors.lastname: Ashley Morrow
authors.forename: Barbra A
authors.initials: BA
authors.lastname: Richardson
authors.forename: Kishorchandra
authors.initials: K
authors.lastname: Mandaliya
authors.forename: Jeckoniah
authors.initials: J
authors.lastname: Ndinya-Achola
authors.forename: Job
authors.initials: J
authors.lastname: Bwayo
authors.forename: Joan
authors.initials: J
authors.lastname: Kreiss
mesh_terms: D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000821:virology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000097:blood; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism / Q000821:virology*; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D007963:Leukocytes, Mononuclear / Q000821:virology; D009055:Mouth / Q000378:metabolism / Q000821:virology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012463:Saliva / Q000821:virology; D012514:Sarcoma, Kaposi / Q000150:complications / Q000821:virology; D011477:Sex Work; D014621:Vagina / Q000821:virology; D017201:Virus Shedding
chemical_list: D004279:DNA, Viral