title: A comparison of rotation- and blob-based system models for 3D SPECT with depth-dependent detector response.
abstract: We compare two different implementations of a 3D SPECT system model for iterative reconstruction, both of which compensate for non-uniform photon attenuation and depth-dependent system response. One implementation performs fast rotation of images represented using a basis of rectangular voxels, whereas the other represents images using a basis of rotationally symmetric volume elements. In our simulations the blob-based approach was found to slightly outperform the rotation-based one in terms of the bias-variance tradeoff in the reconstructed images. Their difference can be significant, however, in terms of computational load. The rotation-based method is faster for many typical SPECT reconstruction problems, but the blob-based one can be better-suited to cases where the reconstruction algorithm needs to process one volume element at a time.
authors.affiliation: Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA. nastazia@eecs.umich.edu
authors.forename: A
authors.initials: A
authors.lastname: Yendiki
authors.forename: J A
authors.initials: JA
authors.lastname: Fessler
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D019544:Equipment Failure Analysis / Q000379:methods; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D008954:Models, Biological; D015233:Models, Statistical; D009716:Numerical Analysis, Computer-Assisted; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012399:Rotation; D012680:Sensitivity and Specificity; D013909:Thorax / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods*; D014159:Transducers