title: Relation of an elevated white blood cell count after percutaneous coronary intervention to long-term mortality.
abstract: Increased inflammatory markers are associated with a poor prognosis after percutaneous coronary intervention. Leukocytes play a key role in inflammation, and an increase in white blood cell (WBC) counts is a nonspecific marker of inflammation. In patients undergoing percutaneous coronary intervention, baseline WBC counts independently predict long-term mortality. In a pooled cohort of patients from the Evaluation of c7E3 for the Prevention of Ischemic Complications (EPIC), the Evaluation in PTCA to Improve Long-term Outcome with abciximab Glycoprotein IIb/IIIa blockade (EPILOG), and Evaluation of Platelet IIb/IIIa inhibitor for STENTing (EPISTENT) trials, postprocedural WBC counts were also found to be an independent predictor of long-term mortality.
authors.affiliation: The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Rajagopal
authors.forename: Hitinder S
authors.initials: HS
authors.lastname: Gurm
authors.forename: Deepak L
authors.initials: DL
authors.lastname: Bhatt
authors.forename: A Michael
authors.initials: AM
authors.lastname: Lincoff
authors.forename: James E
authors.initials: JE
authors.lastname: Tcheng
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Kereiakes
authors.forename: Neal S
authors.initials: NS
authors.lastname: Kleiman
authors.forename: Gang
authors.initials: G
authors.lastname: Jia
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Topol
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000401:mortality* / Q000628:therapy*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015999:Multivariate Analysis; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D016019:Survival Analysis