Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein.
Herpetic stromal keratitis (HSK) is a T cell-orchestrated, immunoinflammatory lesion that results from corneal Herpes simplex virus infection. Previous reports indicate an essential role for proinflammatory cytokine interleukin (IL)-1 in HSK pathogenesis. The present study evaluates the efficacy of IL-1 receptor antagonist (IL-1 ra) protein in the management of HSK. Mice receiving IL-1 ra had diminished disease severity. The administration of IL-1 ra was shown to reduce the influx into the cornea of cells of the innate and adaptive immune response. In addition, the treatment diminished corneal vascular endothelial growth factor levels, resulting in reduced angiogenic response. Our results show the importance of targeting early proinflammatory molecules such as IL-1 to counteract HSK and advocate IL-1 ra as an effective agent to achieve this.
Biswas
Partha Sarathi
PS
Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Banerjee
Kaustuv
K
Zheng
Mei
M
Rouse
Barry T
BT
D000818:Animals; D016510:Corneal Neovascularization / Q000517:prevention & control; D003319:Corneal Stroma / Q000276:immunology*; D005260:Female; D018259:Herpesvirus 1, Human / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000378:metabolism; D016849:Keratitis, Herpetic / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012795:Sialoglycoproteins / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
C507763:IL1RN protein, human; C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D042461:Vascular Endothelial Growth Factor A