title: Immunohistochemical localisation of 3beta-hydroxysteroid dehydrogenase in Sarcocystis spp.
abstract: 3Beta-hydroxysteroid-dehydrogenase (3beta-HSD) is an isoenzyme that catalyses an essential step in the synthesis of all classes of active steroid hormones. The presence of steroid hormones of the vertebrate type in invertebrates is acknowledged in addition to a group of steroid-like hormones called ecdysteroids that were present in arthropods and helminths. In the present study, 3beta-HSD was detected in the bradyzoites enclosed in sarcocysts of Sarcocystis spp. with immunohistochemistry. The results suggest that self-originating steroid hormones may play important roles in the development of Sarcocystis spp., and possibly in the regulation of the reciprocal immune interaction between the host and these parasites.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, University of Kirikkale, Yahsihan, Turkey. myarim@omu.edu.tr
authors.forename: Murat
authors.initials: M
authors.lastname: Yarim
authors.forename: Kader
authors.initials: K
authors.lastname: Yildiz
authors.forename: Nalan
authors.initials: N
authors.lastname: Kabakci
authors.forename: Siyami
authors.initials: S
authors.lastname: Karahan
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D007150:Immunohistochemistry; D018482:Muscle, Skeletal / Q000469:parasitology; D012522:Sarcocystis / Q000201:enzymology* / Q000254:growth & development / Q000472:pathogenicity; D012523:Sarcocystosis / Q000469:parasitology / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology
chemical_list: D015096:3-Hydroxysteroid Dehydrogenases