Is the common carotid artery intima-media thickness associated with functional outcome after acute ischaemic stroke?
BACKGROUND
Common carotid artery intima-media thickness (CCA-IMT) is an independent and early marker of generalised atherosclerosis. Brain affected by atherosclerosis may be more vulnerable to an ischaemic insult.


OBJECTIVE
To investigate the association between CCA-IMT and functional outcome after an acute ischaemic stroke.


METHODS
Prospective cohort analysis.


METHODS
284 consecutive patients (mean (SD) age, 68.7 (12.7) years, 126 (44%) female) with an acute ischaemic stroke had carotid ultrasonography, carried out by a single operator. Demographic data, vascular risk factors, initial stroke severity, and brain imaging findings were recorded. Outcome was assessed at seven days from stroke onset, at discharge from hospital, and at one year post-stroke.


RESULTS
CCA-IMT was not significantly associated with adverse short or long term functional outcome in univariate analysis, or after adjustment in a multivariate logistic regression analysis for demographic data, initial stroke severity, conventional vascular risk factors, and the characteristics of the ischaemic lesion. Age and initial stroke severity were the only independent predictors of outcome.


CONCLUSIONS
CCA-IMT was not associated with adverse functional outcome after an ischaemic stroke. Adding CCA-IMT in a prediction model for stroke outcome would probably not improve the power of the model.
Ellul
J
J
Department of Neurology, University of Patras, Greece. ellul@otenet.gr
Talelli
P
P
Terzis
G
G
Chrysanthopoulou
A
A
Gioldasis
G
G
Papapetropoulos
T
T
D000208:Acute Disease; D017668:Age of Onset; D000368:Aged; D002545:Brain Ischemia / Q000473:pathology*; D017536:Carotid Artery, Common / Q000033:anatomy & histology* / Q000473:pathology*; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D020521:Stroke / Q000473:pathology*; D017539:Tunica Intima / Q000033:anatomy & histology* / Q000473:pathology*; D017540:Tunica Media / Q000033:anatomy & histology* / Q000473:pathology*