Neutron capture autoradiographic study of the biodistribution of 10B in tumor-bearing mice.
For the study on boron neutron capture therapy, the whole-body sections of tumor-bearing mice infused with 10B attached to CR-39 plastic track detectors were exposed to thermal and cold neutron beams. Neutron capture autoradiographic images obtained by the cold neutron irradiation were extremely superior in quality to those of the thermal neutron beams. From the autoradiographic images, the 10B reaction dose of the neutron-induced particles was estimated using the differential LET distribution.
Ogura
K
K
High Technology Research Center, College of Industrial Technology, Nihon University, 1-2-1, Izumi-cho, Narashino, Chiba 275-0005, Japan. ogura@mmm.cit.nihon-u.ac.jp
Yanagie
H
H
Eriguchi
M
M
Lehmann
E H
EH
Kühne
G
G
Bayon
G
G
Kobayashi
H
H
D000818:Animals; D001345:Autoradiography / Q000379:methods; D001822:Body Burden; D001895:Boron / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000532:radiotherapy; D007554:Isotopes; D008571:Men; D051379:Mice; D009502:Neutrons / Q000627:therapeutic use; D009928:Organ Specificity; D011874:Radiometry / Q000379:methods*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods
D007554:Isotopes; D019275:Radiopharmaceuticals; D001895:Boron