title: Plasma cell granuloma of the thyroid and Hashimoto thyroiditis.
abstract: Plasma cell granuloma of the thyroid is a rare tumor-like lesion formed by a localized proliferation of inflammatory cells, supported by a stroma of fibrous tissue. Few cases have been previously reported in the medical literature. We report a new case of a 41-year-old man presenting a goiter with primary hypothyroidism (thyroid-stimulating hormone, 70 mIU/L; free thyroxine, < 0.01 pmol/L; triiodothyronine, 0.66 nmol/L) and elevation of thyroid antibodies. Several fine-needle aspiration biopsies of the thyroid were fruitless and total thyroidectomy was performed. Histologic and immunohistochemical study demonstrated the polyclonal nature of the cells and yielded a diagnosis of plasma cell granuloma. Histologic findings of Hashimoto thyroiditis were present too.
authors.affiliation: Department of Endocrinology and Nutrition, University Hospital La Fe, Valencia, Spain. ferrer_jc@hotmail.com
authors.forename: J C
authors.initials: JC
authors.lastname: Ferrer-García
authors.forename: P
authors.initials: P
authors.lastname: Costa-Talens
authors.forename: J F
authors.initials: JF
authors.lastname: Merino-Torres
authors.forename: M
authors.initials: M
authors.lastname: Prieto-Rodríguez
authors.forename: J F
authors.initials: JF
authors.lastname: Vera-Sempere
authors.forename: F
authors.initials: F
authors.lastname: Piñón-Sellés
mesh_terms: D000328:Adult; D006104:Granuloma, Plasma Cell / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013959:Thyroid Diseases / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology*