title: Spirastrellolide A: revised structure, progress toward the relative configuration, and inhibition of protein phosphatase 2A.
abstract: [structure: see text] The structure of spirastrellolide A, a novel macrolide isolated from the marine sponge Spirastrella coccinea, has been revised to accommodate new MS and chemical transformation data. Relative configurations of three major fragments of the molecule have been elucidated from ROESY and coupling constant data. Spirastrellolide A has been shown to be a potent and fairly selective inhibitor of protein phosphatase 2A.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada.
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
authors.forename: Marshall
authors.initials: M
authors.lastname: Lapawa
authors.forename: Xidong
authors.initials: X
authors.lastname: Feng
authors.forename: Tamsin
authors.initials: T
authors.lastname: Tarling
authors.forename: Michel
authors.initials: M
authors.lastname: Roberge
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D011161:Porifera / Q000737:chemistry*; D054648:Protein Phosphatase 2; D013141:Spiro Compounds
chemical_list: D004791:Enzyme Inhibitors; D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2