title: Malassezia furfur meningitis associated with total parenteral nutrition subdural effusion.
abstract: We present a case of Malassezia furfur meningitis arising in a very low birth weight infant with chronic lung disease, necrotizing enterocolitis, and intraventricular hemorrhage. M. furfur meningitis was probably acquired late following successful treatment for earlier systemic central line-associated M. furfur infection. M. furfur meningitis has only once been previously reported. Unlike the previous case where meningitis was secondary to widespread blood-borne dissemination, infection was limited to the leptomeninges and arose in association with extravasation of total parenteral nutrition (TPN) and intralipid fluid into subarachnoid space via peripheral scalp catheter.
authors.affiliation: Department of Pathology, Truman Medical Center, 2301 Holmes Street, Kansas City, MO 64108, USA.
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Rosales
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Jackson
authors.forename: David
authors.initials: D
authors.lastname: Zwick
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002404:Catheterization / Q000009:adverse effects; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002543:Cerebral Hemorrhage / Q000150:complications; D002908:Chronic Disease; D020345:Enterocolitis, Necrotizing / Q000150:complications; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects; D017809:Fatal Outcome; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008171:Lung Diseases / Q000150:complications; D008290:Malassezia; D008297:Male; D016921:Meningitis, Fungal / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects* / Q000295:instrumentation; D013353:Subdural Effusion / Q000209:etiology* / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D005217:Fat Emulsions, Intravenous; D000666:Amphotericin B