title: Conversion from tacrolimus to cyclosporine for a non-dose-dependent tacrolimus-induced toxicity, a pediatric kidney transplant recipient case report.
abstract: Tacrolimus-induced toxicity is considered a dose-related side effect largely due to a direct action of this potent calcineurin inhibitor on its targets including the kidney and the pancreas. This paper describes a case of tacrolimus systemic toxicity that appeared in a pediatric kidney transplant recipient who received a low drug dose. The kidney biopsy was a crucial aid toward the correct diagnosis, which reversed upon conversion to cyclosporine-based immunosuppression. A review of the literature suggests a chance of systemic toxicity even when the patient is maintained on therapeutic levels of tacrolimus. Because idiosyncratic reactions to the drug have not yet been postulated, we conclude that this suspicion may be addressed by a safe conversion to cyclosporine in pediatric patients.
authors.affiliation: Division of Paediatric Nephrology, Istituti Clinici di Perfezionamento, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ghio
authors.forename: M
authors.initials: M
authors.lastname: Ferraresso
authors.forename: M
authors.initials: M
authors.lastname: Giani
authors.forename: M
authors.initials: M
authors.lastname: Mihatsch
authors.forename: A
authors.initials: A
authors.lastname: Edefonti
mesh_terms: D000293:Adolescent; D016572:Cyclosporine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004655:Emulsions; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D016559:Tacrolimus / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D004655:Emulsions; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus