title: Anemia prevalence and associated risk factors in a single-center ambulatory HIV clinical cohort.
abstract: The prevalence of anemia in HIV-infected persons has not been well characterized in the HAART era. In a single-center, retrospective study, anemia prevalence and risk factors, including use of HAART, were assessed in an ambulatory clinical cohort of 758 HIV-infected patients for the calendar year 2000. The relationships between anemia (hemoglobin level less than 12.5 g/dL) and demographic variables, antiretroviral treatment regimens, and disease markers were analyzed. Mean baseline patient characteristics were hemoglobin level, 13.7 +/- 1.9 g/dL; CD4+ cell count, 405 +/- 293/microL; and HIV RNA level, 77,841 +/- 148,394 copies/mL. Overall anemia prevalence was 30.3%. Multivariate logistic regression analysis demonstrated that anemia was associated with a CD4+ cell count below 50/microL, female sex, black race, a viral load above 100,000 copies/mL, zidovudine use, and older age. Severe anemia was less prevalent in this study population than in historical comparators; however, mild to moderate anemia rates remain high.
authors.affiliation: University of South Florida, Tampa, Florida, USA.
authors.forename: Todd S
authors.initials: TS
authors.lastname: Wills
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Nadler
authors.forename: Charurut
authors.initials: C
authors.lastname: Somboonwit
authors.forename: Albert
authors.initials: A
authors.lastname: Vincent
authors.forename: Gerhard
authors.initials: G
authors.lastname: Leitz
authors.forename: Kimberly
authors.initials: K
authors.lastname: Marino
authors.forename: Eknath
authors.initials: E
authors.lastname: Naik
authors.forename: Stacy
authors.initials: S
authors.lastname: Powers
authors.forename: Nadeem
authors.initials: N
authors.lastname: Khan
authors.forename: Brent
authors.initials: B
authors.lastname: Laartz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000740:Anemia / Q000150:complications / Q000453:epidemiology*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005431:Florida / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D019562:Viral Load