The C-glycoside analogue of the immunostimulant alpha-galactosylceramide (KRN7000): synthesis and striking enhancement of activity.
Yang
Guangli
G
Department of Chemistry, Hunter College of CUNY, New York, NY 10021, USA.
Schmieg
John
J
Tsuji
Moriya
M
Franck
Richard W
RW
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D003602:Cytotoxicity, Immunologic; D004305:Dose-Response Relationship, Drug; D005699:Galactosylceramides / Q000138:chemical synthesis* / Q000276:immunology / Q000627:therapeutic use; D006027:Glycosides; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D009005:Monosaccharides / Q000138:chemical synthesis*; D034101:Sporozoites / Q000187:drug effects / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; C438934:C-glycoside; D005699:Galactosylceramides; D006027:Glycosides; D009005:Monosaccharides; C103873:KRN 7000