[Clinical evaluation of IL-1beta and TNF-alpha in prostatic secretions for chronic prostatitis].
OBJECTIVE
To determine the clinical significance of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha( TNF-alpha) in expressed prostatic secretions(EPS) for chronic prostatitis.


METHODS
Prostatic secretions IL-1beta and TNF-alpha were evaluated for 34 patients with chronic prostatitis, 10 with asymptomatic inflammatory prostatitis, 12 with benign prostatic hyperplasia (BPH) and 8 health controls by enzyme-linked immunosorbent assay (ELISA).


RESULTS
IL-1beta and TNF-alpha levels in EPS in the patients of chronic prostatitis with WBC > or = 10/HP and asymptomatic inflammatory prostatitis were obviously higher than those of chronic prostatitis with WBC < 10/HP, BPH and health controls, (P < 0.05 and P < 0.02). There was a correlation between IL-1beta and TNF-alpha (P < 0.003) but none between WBC and IL-1beta or TNF-alpha.


CONCLUSIONS
Cytokines are frequently elevated in EPS in men of chronic prostatitis with high WBC and asymptomatic inflammatory prostatitis, which provides a novel means different from traditional methods based on WBC for the identification of men with chronic prostatitis.
Yang
Jinyi
J
Department of Urology, Friendship Hospital of Dalian, Dalian, Liaoning 116001, China. lishao89@hotmail.com
Ye
Lin
L
Jiang
Hongbo
H
Zhou
Jie
J
Hou
Xu
X
Deng
Xin
X
D000368:Aged; D002908:Chronic Disease; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000737:chemistry / Q000378:metabolism*; D011472:Prostatitis / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha