Syntheses and GABA uptake properties of 6-ether- and 6-enol ether-substituted nipecotic acids.
6-aralkylether- and 6-arylenol-ether-substituted nipecotic acids were synthesized. These analogues are poor GABA uptake inhibitors. The electronegative region concept developed in the N-substituted nipecotic acid series cannot be transferred on the side chain of this series of 6-substituted analogues.
N'Goka
Victor
V
Laboratoire de pharmacochimie de la communication cellulaire UMR7081 du CNRS, faculté de pharmacie, 74 route du Rhin, 67401 Illkirch, France.
Bissantz
Caterina
C
Bisel
Philippe
P
Stenbøl
Tine B
TB
Krogsgaard-Larsen
Povl
P
Schlewer
Gilbert
G
D004987:Ethers; D009557:Nipecotic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000493:pharmacokinetics*
D004987:Ethers; D009557:Nipecotic Acids; D005680:gamma-Aminobutyric Acid