Ivermectin resistant and susceptible third-stage larvae of Haemonchus contortus: cholinesterase and phosphatase activities.
Cholinesterase and acid phosphatase (AP), but not alkaline phosphatase activities, were detected in cytosolic and membrane-bound fractions of ivermectin resistant and susceptible Haemonchus contortus infective-stage larvae. Some differences in acetylcholinesterase activity of cytosolic fractions and in the AP activity of these fractions as well as in the response to AP inhibitors by membrane-bound fractions were detected. Data are discussed.
Giménez-Pardo
Consuelo
C
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá, Ctra, Madrid-Barcelona km 33, 28871 Alcalá de Henares, Madrid, España. consuelo.gimenez@uah.es
Martínez-Grueiro
Maria Mercedes
MM
Gómez-Barrio
Alicia
A
Rodríguez-Caabeiro
Filomena
F
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D002802:Cholinesterases / Q000378:metabolism*; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D004351:Drug Resistance; D006189:Haemonchus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D007559:Ivermectin / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000201:enzymology
D000871:Anthelmintics; D002800:Cholinesterase Inhibitors; D007559:Ivermectin; D002802:Cholinesterases; D000135:Acid Phosphatase