Neurofibromatosis type 1 associated with central nervous system lymphoma.
OBJECTIVE
To report the occurrence of central nervous system (CNS) lymphoma in a patients with neurofibromatosis type 1 (NF1).


METHODS
Interventional case report.


METHODS
A 47-year-old male with a parieto-occipital lobe lesion was referred for ocular evaluation. Skin, brain, and vitreous biopsies were performed.


RESULTS
The discovery of Lisch nodules of the iris prompted a physical examination that revealed cutaneous stigmata of NF1. Biopsy of the CNS lesion revealed diffuse large B-cell lymphoma. Biopsy of papules on the back and abdomen were compatible with neurofibroma. No malignant cells were found in the vitreous specimen. A clinical diagnosis of NF1 was made.


CONCLUSIONS
This is the first report of CNS lymphoma in a patient with NF1. Additional reports may shed more light on the possible association between the two conditions.
Zein
Ghassan
G
Ocular Immunology & Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.
Yu
Ellen
E
Tawansy
Khaled
K
Berta
András
A
Foster
C Stephen
CS
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
D000970:Antineoplastic Agents; D008727:Methotrexate