title: Low-intensity indocyanine-green laser phototherapy of acne vulgaris: pilot study.
abstract: Near infrared (NIR) diode laser low-intensity (soft) phototherapy with the topical application of indocyanine green (ICG) has been suggested for treatment of acne vulgaris. Twelve volunteers with acne lesions on their faces and/or backs were enrolled in the experiment. Skin areas of the subjects that were 4 x 5 cm2 were stained with ICG solution for 5 min before laser irradiation (803 nm) at a power density up to 50 mW/cm2 for 5 to 10 min. For 75% of the subjects, a single treatment was provided and for the other 25%, eight sequential treatments over a period of a month were carried out. Observations a month after the completion of the treatment showed that only the multiple treatments with a combination of ICG and NIR irradiation reduced inflammation and improved the state of the skin for a month without any side effects. A month after treatment, the improvement was about 80% for the group receiving multiple treatments. Single treatments did not have a prolonged effect.
authors.affiliation: Saratov State University, Optics Department, Astrakhanskaya 83, Saratov 410026, Russia. eagenina@optics.sgu.ru
authors.forename: Elina A
authors.initials: EA
authors.lastname: Genina
authors.forename: Alexey N
authors.initials: AN
authors.lastname: Bashkatov
authors.forename: Georgy V
authors.initials: GV
authors.lastname: Simonenko
authors.forename: Olga D
authors.initials: OD
authors.lastname: Odoevskaya
authors.forename: Valery V
authors.initials: VV
authors.lastname: Tuchin
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Altshuler
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage*; D007259:Infrared Rays / Q000627:therapeutic use*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D007208:Indocyanine Green