Development through the eyes of functional genomics.
In many of the model organisms used to study development, it is becoming relatively routine to carry out global analyses of gene function. These analyses take many forms, from microarray analyses to the construction of physical interaction maps to the systematic analyses of loss-of-function phenotypes. Such large-scale datasets can be integrated to generate complex gene networks, and we explore how these gene networks can contribute to an understanding of developmental pathways. In particular, we examine how combining large-scale expression experiments and gene networks may move us towards a molecular description of the events of development, embodied in a succession of stage-specific subnetworks sampled from an organism's overall gene network.
Fraser
Andrew G
AG
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. agf@sanger.ac.uk
Marcotte
Edward M
EM
D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D047108:Embryonic Development / Q000235:genetics* / Q000502:physiology; D015870:Gene Expression; D023281:Genomics / Q000379:methods*; D011506:Proteins / Q000378:metabolism*
D011506:Proteins