title: Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity.
abstract: A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.
authors.affiliation: Dipartimento di Tossicologia, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy. tcocco@unica.it
authors.forename: Maria T
authors.initials: MT
authors.lastname: Cocco
authors.forename: Cenzo
authors.initials: C
authors.lastname: Congiu
authors.forename: Valentina
authors.initials: V
authors.lastname: Onnis
authors.forename: Micaela
authors.initials: M
authors.lastname: Morelli
authors.forename: Vicente
authors.initials: V
authors.lastname: Felipo
authors.forename: Omar
authors.initials: O
authors.lastname: Cauli
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008297:Male; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects*; D011725:Pyridines / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D002264:Carboxylic Acids; D009539:Nicotinic Acids; D011725:Pyridines; C407065:trifluoromethylpyridine