Elevated angiogenin levels in the peritoneal fluid of women with endometriosis correlate with the extent of the disorder.
OBJECTIVE
To assess the release of angiogenin into peritoneal fluid in women with and without endometriosis by measuring its concentration with reference to disease stage, presence of red lesions, and phase of the menstrual cycle.


METHODS
Retrospective study.


METHODS
Nagoya City University Hospital.


METHODS
Sixty-four women with endometriosis (n = 38) and cystadenomas (n = 26) for whom surgery was scheduled in the proliferative or secretory phase of the menstrual cycle.


METHODS
Peritoneal fluid samples were obtained at laparotomy or laparoscopy.


METHODS
Angiogenin concentrations in the peritoneal fluid, as measured by ELISA.


RESULTS
Angiogenin concentration in the peritoneal fluid was markedly elevated in the endometriosis patients (median 515 ng/mL, interquartile range 151-1763 ng/mL) compared with the cystadenoma (control) patients (195 ng/mL, 98-324 ng/mL), with values correlating with the extent of the disease. No significant differences between the proliferative phase and the secretory phase were observed in either the controls or the endometriosis patients.


CONCLUSIONS
The inflammation associated with endometriosis, through increasing levels of peritoneal fluid angiogenin, might promote angiogenesis for progression of the disease and correlate with the extent of the disorder.
Suzumori
Nobuhiro
N
Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medicine, Nagoya, Japan. og.n.suz@med.nagoya-cu.ac.jp
Zhao
Xaio Xi
XX
Suzumori
Kaoru
K
D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D001202:Ascitic Fluid / Q000378:metabolism*; D015331:Cohort Studies; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D010535:Laparoscopy; D007813:Laparotomy; D008597:Menstrual Cycle; D008875:Middle Aged; D009994:Osmolar Concentration; D012189:Retrospective Studies; D012259:Ribonuclease, Pancreatic / Q000378:metabolism*; D012720:Severity of Illness Index
D043925:Angiogenesis Inducing Agents; C046366:angiogenin; D012259:Ribonuclease, Pancreatic