Palladium-catalyzed reaction of 2-hydroxy-2-methylpropiophenone with aryl bromides: a unique multiple arylation via successive C-C and C-H bond cleavages.
2-Hydroxy-2-methylpropiophenone undergoes a unique multiple arylation via C-C and C-H bond cleavages upon treatment with excess aryl bromides in the presence of a palladium catalyst to give 1,1,2,2-tetraarylethanes and 4,4-diaryl-1-phenylisochroman-3-ones.
Wakui
Hiroyuki
H
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Kawasaki
Satoshi
S
Satoh
Tetsuya
T
Miura
Masahiro
M
Nomura
Masakatsu
M
D000478:Alkylation; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011427:Propiophenones / Q000138:chemical synthesis / Q000737:chemistry*
D006842:Hydrocarbons, Brominated; D011427:Propiophenones; D010165:Palladium; D002244:Carbon; C492094:2-hydroxy-2-methylpropiophenone