CRF1 receptor antagonist CP-154,526 reduces cardiovascular responses during acute psychological stress in rabbits.
We examined the effect of CP-154,526 on cardiovascular changes elicited in conscious rabbits by stressful stimuli (loud sound, cage move, pinprick, formaldehyde vapour and air-jet stress). CP-154,526 substantially reduced pressor and heart rate responses to these stimuli (both vagally and sympathetically mediated), and reduced QT shortening during air-jet stress. Blocking of central CRF1 receptors attenuates cardiovascular responses to environmental stimuli, presumably by affecting brain centres that control cardiovascular functions.
Nalivaiko
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Department of Physiology, Centre for Neuroscience, Flinders University, Australia. eugene.nalivaiko@flinders.edu.au
Blessing
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D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004569:Electroencephalography / Q000379:methods; D006339:Heart Rate / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D011817:Rabbits; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology*
D000319:Adrenergic beta-Antagonists; C101628:CP 154526; D011743:Pyrimidines; D011758:Pyrroles; D018019:Receptors, Corticotropin-Releasing Hormone; D011433:Propranolol