Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris.
A polysaccharide from the water extract of cultured Cordyceps militaris was isolated through ethanol precipitation, deproteination and gel-filtration chromatography. Their molecular weight was determined using gel-filtration chromatography. The structure of polysaccharide CPS-1 was elucidated by sugar analysis, Smith degradation, IR and 13C-NMR spectroscopy. CPS-1 was shown to possess a significant antiinflammatory activity and suppressed the humoral immunity in mice but had no significant effects on the cellular immunity and the non-specific immunity.
Yu
Rongmin
R
Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 510632, Guangzhou, China. rongminyu99@hotmail.com
Song
Liyan
L
Zhao
Yu
Y
Bin
Wen
W
Wang
Lei
L
Zhang
Hui
H
Wu
Yihang
Y
Ye
Wencai
W
Yao
Xinsheng
X
D019342:Acetic Acid; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects*; D032661:Cordyceps; D003436:Croton Oil; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006461:Hemolysis; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010587:Phagocytosis / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D011134:Polysaccharides; D003436:Croton Oil; D019342:Acetic Acid