title: Half-inhibition concentrations of new cholinesterase inhibitors.
abstract: The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer's disease treatment--rivastigmine and galanthamine.
authors.affiliation: Faculty of Chemical Technology, University of Pardubice, Department of Physical Chemistry, Pardubice, Czech Republic. ZdrazilovaP@atlas.cz
authors.forename: Pavla
authors.initials: P
authors.lastname: Zdrazilová
authors.forename: Sárka
authors.initials: S
authors.lastname: Stepánková
authors.forename: Karel
authors.initials: K
authors.lastname: Komers
authors.forename: Karel
authors.initials: K
authors.lastname: Ventura
authors.forename: Alexander
authors.initials: A
authors.lastname: Cegan
mesh_terms: D000818:Animals; D002091:Butyrylcholinesterase / Q000097:blood / Q000378:metabolism*; D002219:Carbamates; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006736:Horses; D007700:Kinetics
chemical_list: D002219:Carbamates; D002800:Cholinesterase Inhibitors; D002091:Butyrylcholinesterase