Mitochondrial dysfunction is a common phenotype in aging and cancer.
An interesting clue with regard to molecular mechanisms underlying age-associated cancers is the apparent defect in mitochondrial function. Recent studies demonstrate a progressive decline in mitochondrial function during aging. Studies have established that the decline in mitochondrial function is due to the accumulation of mutations in mitochondrial DNA. These observations suggest that the mitochondrial dysfunction that accompanies aging may exert a major influence on carcinogenesis.
Singh
Keshav K
KK
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA. keshav.singh@roswellpark.org
D000375:Aging; D000818:Animals; D017209:Apoptosis; D017173:Caenorhabditis elegans; D002467:Cell Nucleus / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000378:metabolism; D016678:Genome; D005838:Genotype; D006801:Humans; D008928:Mitochondria / Q000473:pathology*; D009154:Mutation; D009369:Neoplasms / Q000473:pathology*; D018384:Oxidative Stress; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D004272:DNA, Mitochondrial