The role of adenosine-related genes variants in susceptibility to essential hypertension.
OBJECTIVE
To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH).


METHODS
Case-control association study investigating gene variants for the ADORA1, ADORA2a and ADA genes.


METHODS
The study used a cohort of 249 unrelated hypertensive individuals who were diagnosed with hypertension, and an age, sex and ethnically matched group of 249 normotensive controls.


RESULTS
The association analysis indicated that both allele and genotype frequencies did not differ significantly between the case and control groups (P > 0.05) for any of the markers tested.


CONCLUSIONS
The adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives. However, involvement of these genes and the adenosine system cannot be conclusively excluded from essential hypertension pathogenesis as other gene variants may still be involved.
Wright
Kirsty
K
Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia.
Tajouri
Lotti
L
Lea
Rod A
RA
Ovcaric
Micky
M
Heux
Stephanie
S
Morin
Fabien
F
Bey
Wallid
W
Headrick
John P
JP
Griffiths
Lyn R
LR
D000241:Adenosine / Q000235:genetics; D000243:Adenosine Deaminase / Q000235:genetics*; D000368:Aged; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D043682:Receptor, Adenosine A1 / Q000235:genetics*; D043705:Receptor, Adenosine A2A / Q000235:genetics*
D005819:Genetic Markers; D043682:Receptor, Adenosine A1; D043705:Receptor, Adenosine A2A; D000243:Adenosine Deaminase; D000241:Adenosine