Pre-administration of beta-carotene protects tissue glutathione and lipid peroxidation status following exposure to gamma radiation.
The present study has been aimed to investigate the protective effect of beta-carotene against radiation-induced oxidative stress in mice tissues using lipid peroxidation and glutathione (GSH) as end points. Fourteen days oral priming administration of beta-carotene (35 mg/kg body weight) followed by an acute dose of gamma radiation (5 Gy) inhibited the augmented level of thiobarbituric acid reactive substance (TBARS) and a statistically significant protection against GSH depletion. Results evaluated from this study clearly indicate the antioxidative property of beta-carotene against gamma radiation, which is suggestive of free radical scavenging and singlet oxygen quenching.
Manda
K
K
Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur-302 004, India.
Bhatia
A L
AL
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D005720:Gamma Rays; D005978:Glutathione / Q000187:drug effects* / Q000528:radiation effects; D007668:Kidney / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D013154:Spleen / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D019207:beta Carotene / Q000494:pharmacology*
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D019207:beta Carotene; D005978:Glutathione