Possible association between HPV16 E7 protein level and cytokeratin 19.
The mechanisms employed by human papillomaviruses (HPVs) to control the replication of the viral genome and the expression of the viral genes are extremely complex and further complicated by the fact that the viral life cycle is intricately tied to the differentiation program of its host epithelial tissue. Indeed, HPV-induced immortalization of keratinocytes and disruption of the normal cytokeratin (CK) expression pattern progress pari passu during the stepwise process that preludes to squamous cell carcinoma. In our study, we have analyzed the interaction occurring between HPV type 16 E7 mRNA and the intermediate cytokeratin filaments 7 and 19 and report data in favor of a possible association between HPV16 E7 protein level and CK19.
Favia
Gianfranco
G
Department of Odontostomatology and Surgery, University of Bari, Bari, Italy.
Kanduc
Darja
D
Lo Muzio
Lorenzo
L
Lucchese
Alberta
A
Serpico
Rosario
R
D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology / Q000821:virology*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053552:Keratin-7; D015603:Keratinocytes; D007633:Keratins / Q000096:biosynthesis*; D009856:Oncogene Proteins, Viral / Q000032:analysis / Q000096:biosynthesis*; D027383:Papillomaviridae / Q000235:genetics* / Q000502:physiology; D050725:Papillomavirus E7 Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology*; D016335:Zinc Fingers
C507497:KRT7 protein, human; D053552:Keratin-7; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C059731:oncogene protein E7, Human papillomavirus type 16; D007633:Keratins