Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats.
Five fractions (F1-F5) isolated from the methanolic leaf extract of Cissampelos mucronata A. Rich were investigated for antiulcer activity. At the dose of 450 mg/kg, they showed varying degree of protection against ulcer induced by indomethacin; the order of protection being F1>F4>F5>F2>F3. The antiulcer potency of F1 and F2 is comparable with that of cimetidine (100 mg/kg, i.p.). Inhibition of gastric mucosal damage may partly contribute to the antiulcer activity of the fractions.
Nwafor
S V
SV
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. svnwafor@hotmail.com
Akah
P A
PA
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D031606:Cissampelos / Q000737:chemistry; D005260:Female; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D000432:Methanol / Q000737:chemistry / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D007213:Indomethacin; D000432:Methanol