title: Amount of DNA in plasma and cancer risk: a prospective study.
abstract: Levels of plasma DNA concentrations in cancer patients have been shown to be higher than the plasma DNA concentrations found in healthy subjects. The value of plasma DNA levels for development of neoplastic or pulmonary disease was evaluated in a large prospective study. Plasma samples (n = 1,184) were analyzed from 776 controls, 359 cases of cancer (lung, bladder, oral cavity, pharynx, larynx, leukemia) and 49 deaths from chronic obstructive pulmonary disease (COPD), including never smokers and ex-smokers, from 9 countries across Europe. The amount of plasma DNA was variable across the European Prospective Investigation into Cancer and Nutrition (EPIC) centers. High DNA concentrations in some centers might be due to the type of population recruited and/or the treatment of the samples. An elevated and statistically significant odds ratio (OR) was found for COPD deaths (OR = 2.53; 95% CI = 1.06-6.02), while nonsignificant increased ORs were present for oral cancers, cancers of the pharynx and larynx and leukemia. When the analyses were stratified by time since recruitment (below or above 36 months), the increased ORs were limited to the more recent period of recruitment, i.e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPD deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% CI = 1.20-4.67).
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Gormally
authors.forename: Pierre
authors.initials: P
authors.lastname: Hainaut
authors.forename: Elodie
authors.initials: E
authors.lastname: Caboux
authors.forename: Luisa
authors.initials: L
authors.lastname: Airoldi
authors.forename: Herman
authors.initials: H
authors.lastname: Autrup
authors.forename: Christian
authors.initials: C
authors.lastname: Malaveille
authors.forename: Alison
authors.initials: A
authors.lastname: Dunning
authors.forename: Seymour
authors.initials: S
authors.lastname: Garte
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Matullo
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Anne
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authors.lastname: Tjonneland
authors.forename: Francoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Petra H
authors.initials: PH
authors.lastname: Peeters
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Gonzalez
authors.forename: Carmen
authors.initials: C
authors.lastname: Martinez
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte
authors.forename: M Jose
authors.initials: MJ
authors.lastname: Tormo
authors.forename: J Ramón
authors.initials: JR
authors.lastname: Quiros
authors.forename: Goran
authors.initials: G
authors.lastname: Berglund
authors.forename: Goran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Day
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Key
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Veglia
authors.forename: Marco
authors.initials: M
authors.lastname: Peluso
authors.forename: Teresa
authors.initials: T
authors.lastname: Norat
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Saracci
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004247:DNA / Q000097:blood*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000235:genetics; D012307:Risk Factors
chemical_list: D004247:DNA