Influence of antiangiogenic fraction from Diogenes avarus (Heller) on fertility and implantation in mice.
The methanol extract isolated from hermit crab, D. avarus degenerated ovarion and uterine tissues in cyclic and pregnant mice, treated before and after the implantation. Immunohistochemical staining using CD31 and Factor VIII specific to endothelial cells showed reduction in microvessel density. The hormonal assay showed decrease in the progesterone secretion in all experimental mice.
Pathare
Sujala
S
Department Of Zoology, D G Ruparel College, Mahim, Mumbai 400 016, India.
Bhivgade
D A
DA
Indap
Madhavi
M
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D033381:Anomura; D010064:Embryo Implantation; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D005169:Factor VIII / Q000096:biosynthesis; D005260:Female; D005298:Fertility; D007150:Immunohistochemistry; D008297:Male; D000432:Methanol / Q000378:metabolism*; D051379:Mice; D008833:Microcirculation; D008854:Microscopy, Electron; D010053:Ovary / Q000378:metabolism; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000096:biosynthesis; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000097:blood / Q000378:metabolism; D013997:Time Factors; D014599:Uterus / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011374:Progesterone; D005169:Factor VIII; D000432:Methanol