title: Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors.
abstract: Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.
authors.affiliation: Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy. mantovani@marionegri.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Paola
authors.initials: P
authors.lastname: Allavena
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
authors.forename: Annunciata
authors.initials: A
authors.lastname: Vecchi
authors.forename: Massimo
authors.initials: M
authors.lastname: Locati
authors.forename: Antonio
authors.initials: A
authors.lastname: Sica
mesh_terms: D018925:Chemokines / Q000502:physiology*; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D018925:Chemokines