Paraneoplastic cholestasis associated with prostate carcinoma.
Paraneoplastic syndromes associated with prostate carcinoma are very rare. We report a patient with prostate carcinoma and cholestatic jaundice without biliary obstruction, hepatic involvement or infectious etiology. In the literature, only one case of idiopathic cholestatic jaundice with prostate carcinoma has been reported and a paraneoplastic etiology was suggested. In our case, cholestasis rapidly regressed with chemotherapy and the patient is well at six months of follow-up. Paraneoplastic cholestasis should be kept in mind in the absence of biliary tract obstruction, hepatic involvement or infectious etiology.
Koruk
Mehmet
M
Department of Gastroenterology, Medical Faculty, Gaziantep University, Gaziantep, Turkey. mkoruk@gantep.edu.tr
Büyükberber
Mehmet
M
Savaş
Cemil
C
Kadayifçi
Abdurrahman
A
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use; D001707:Biopsy, Needle; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy / Q000473:pathology*; D004359:Drug Therapy, Combination; D006801:Humans; D007150:Immunohistochemistry; D041781:Jaundice, Obstructive / Q000188:drug therapy / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000473:pathology*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D018570:Risk Assessment; D016896:Treatment Outcome
D000726:Androgen Antagonists