title: Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum.
abstract: Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl (3) extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC (50) value of 3.12 micro M.
authors.affiliation: Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-dong, Yusong-gu, Taejon 305-333, Korea.
authors.forename: Seung Woong
authors.initials: SW
authors.lastname: Lee
authors.forename: Mun-Chual
authors.initials: MC
authors.lastname: Rho
authors.forename: Jung Yeon
authors.initials: JY
authors.lastname: Nam
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Lim
authors.forename: Oh Eok
authors.initials: OE
authors.lastname: Kwon
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Hyun Sun
authors.initials: HS
authors.lastname: Lee
authors.forename: Young Kook
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000475:Alkenes; D000818:Animals; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D005638:Fruit; D006574:Heterocyclic Compounds, 2-Ring; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008517:Phytotherapy; D031701:Piper; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D000097587:Sterol O-Acyltransferase 2
chemical_list: D000475:Alkenes; D004791:Enzyme Inhibitors; D006574:Heterocyclic Compounds, 2-Ring; D010936:Plant Extracts; D002785:Sterol O-Acyltransferase; D000097587:Sterol O-Acyltransferase 2; C492480:guineensine