Aberrant serum adiponectin levels in women with uterine leiomyomas.
BACKGROUND
Adiponectin is an adipocyte-secreted hormone. Serum adiponectin levels are inversely correlated with insulin resistance, and low plasma adiponectin levels have been demonstrated in type 2 diabetic patients. However, information on serum adiponectin levels in gynecological disorders is mostly lacking. In this study, we analyzed the possible correlation between serum adiponectin levels and uterine leiomyomas.


METHODS
Serum adiponectin levels, determined by radioimmunoassay, were compared in women with uterine leiomyomas (n = 47) and normal controls (n = 46).


RESULTS
Serum adiponectin levels in women with uterine leiomyomas (16.4 +/- 0.9 microg/ml) were significantly lower (p < 0.05) than those in the normal controls (19.5 +/- 1.0 microg/ml). Furthermore, there was an inverse correlation between serum adiponectin levels and body mass index, in both women with leiomyomas and normal controls.


CONCLUSIONS
Serum adiponectin levels are significantly decreased in myomatous patients.
Chen
Hung-Sheng
HS
Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC.
Chan
Te-Fu
TF
Chung
Yueh-Fang
YF
Su
Jinu-Huang
JH
Yuan
Shyng-Shiou F
SS
D052242:Adiponectin; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007044:Hysterectomy; D007333:Insulin Resistance / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007889:Leiomyoma / Q000097:blood* / Q000601:surgery; D016014:Linear Models; D011863:Radioimmunoassay; D014594:Uterine Neoplasms / Q000097:blood* / Q000601:surgery
D052242:Adiponectin; D006454:Hemoglobins; D036341:Intercellular Signaling Peptides and Proteins