Vascular hemichorea/hemiballism and topiramate.
Although vascular hemichorea/hemiballism (HC/HB) has been reported to be self-limited, in some cases, it can be irreversible and severely disabling. The standard treatment includes typical and atypical neuroleptics and GABA-mimetic drugs. Topiramate is a new antiepileptic drug possessing a complex mechanism of action, including the enhancement of GABA-mediated inhibition. We describe a 71-year-old patient with HC/HB who markedly improved after topiramate treatment.
Gatto
Emilia Mabel
EM
Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
Uribe Roca
Claudia
C
Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
Raina
Gabriela
G
Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
Gorja
Marcelo
M
Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
Folgar
Silvia
S
Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
Micheli
Federico E
FE
Parkinson's Disease and Movement Disorders Program, Department of Neurosciences, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D001479:Basal Ganglia / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D002819:Chorea / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D020820:Dyskinesias / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020521:Stroke / Q000473:pathology / Q000503:physiopathology; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose