Corticosteroids treatment.
Corticosteroids (Cs) are widely used for treatment of multiple sclerosis (MS) acute relapses because of the potent immunosuppressive and anti-inflammatory properties. As for patients with relapsing-remitting (RR) MS, short-term administrations of Cs markedly less severity of symptoms and promote faster recovery of clinical attacks. Chronic administrations of Cs significantly diminish the formation of T1 hypointense lesions and the progression of brain atrophy. As for patients with secondary progressive MS treatment with Cs delays the time to onset of sustained disability. Finally the association between methylprednisolone and interferon beta (IFNbeta) leads the recovery of active lesions at greater extent and reduces the formation of neutralizing antibodies (NABs) against IFNbeta in patients with RRMS.
Pozzilli
Carlo
C
Department of Neurological Sciences, La Sapienza University, V.le Università 30, 00185 Rome, Italy. carlo.pozzilli@uniromal.it
Marinelli
Fabiana
F
Romano
Silvia
S
Bagnato
Francesca
F
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000906:Antibodies / Q000187:drug effects / Q000276:immunology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D016899:Interferon-beta / Q000276:immunology / Q000494:pharmacology; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D009410:Nerve Degeneration / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D055502:Secondary Prevention
D000305:Adrenal Cortex Hormones; D000906:Antibodies; D007166:Immunosuppressive Agents; D016899:Interferon-beta