title: Recovery from lung injury in survivors of acute respiratory distress syndrome: difference between pulmonary and extrapulmonary subtypes.
abstract: OBJECTIVE
  To determine whether long-term outcome differs between acute respiratory distress syndrome (ARDS) resulting from pulmonary (ARDSp) and extrapulmonary (ARDSexp) causes.
  
  
  METHODS
  Observational study.
  
  
  METHODS
  Medical intensive care unit of a university hospital.
  
  
  METHODS
  Twenty-nine ARDS patients (16 ARDSp and 13 ARDSexp) who survived over 6 months after diagnosis.
  
  
  RESULTS
  The two groups did not differ according to demographic data and severity indices on admission. The duration of ICU stay (median 21 days [interquartile range, 12-43 days] vs 12 [6.5-20] days, p=0.097) tended to be longer and total ventilation time (360 [96-700] h vs 144 [42.5-216] h, p=0.045) were longer in the patients with ARDSp. The ARDSp patients showed more severe abnormalities on thin-section computed tomography (CT), including ground-glass opacity (GGO; 6 [3-16] vs 0 [0-2.5], p=0.002), reticular density (12 [8-14] vs 5 [2-9], p=0.033) and the sum of all four patterns of lesion (20 [11-27] vs 5 [2-12], p=0.006). There were no between-group differences in Spitzer's Quality of Life index and the Chronic Respiratory Questionnaire.
  
  
  CONCLUSIONS
  These results suggest that ARDSp would leave more severe lung sequelae than ARDSexp, but the clinical relevance of their difference is questionable.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 138-736 Songpa-gu, Seoul, Korea.
authors.forename: Sun Jong
authors.initials: SJ
authors.lastname: Kim
authors.forename: Bum Jin
authors.initials: BJ
authors.lastname: Oh
authors.forename: Jin Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Chae-Man
authors.initials: CM
authors.lastname: Lim
authors.forename: Tae Sun
authors.initials: TS
authors.lastname: Shim
authors.forename: Sang Do
authors.initials: SD
authors.lastname: Lee
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Kim
authors.forename: Dong Soon
authors.initials: DS
authors.lastname: Kim
authors.forename: Won Dong
authors.initials: WD
authors.lastname: Kim
authors.forename: Younsuck
authors.initials: Y
authors.lastname: Koh
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D006801:Humans; D007362:Intensive Care Units; D017063:Outcome Assessment, Health Care; D011788:Quality of Life; D012128:Respiratory Distress Syndrome / Q000145:classification / Q000209:etiology* / Q000503:physiopathology*; D012129:Respiratory Function Tests; D016019:Survival Analysis; D017741:Survivors; D013997:Time Factors; D014057:Tomography, X-Ray Computed