A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.
In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.
Braida
Laura
L
Dipartimento di Scienze delle Riproduzione e dello Sviluppo, University of Trieste, Italy.
Boniotto
Michele
M
Pontillo
Alessandra
A
Tovo
Pier Angelo
PA
Amoroso
Antonio
A
Crovella
Sergio
S
D002648:Child; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D023083:beta-Defensins / Q000235:genetics*
C406407:DEFB1 protein, human; D023083:beta-Defensins