title: Elevated angiogenin levels in the peritoneal fluid of women with endometriosis correlate with the extent of the disorder.
abstract: OBJECTIVE
  To assess the release of angiogenin into peritoneal fluid in women with and without endometriosis by measuring its concentration with reference to disease stage, presence of red lesions, and phase of the menstrual cycle.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Nagoya City University Hospital.
  
  
  METHODS
  Sixty-four women with endometriosis (n = 38) and cystadenomas (n = 26) for whom surgery was scheduled in the proliferative or secretory phase of the menstrual cycle.
  
  
  METHODS
  Peritoneal fluid samples were obtained at laparotomy or laparoscopy.
  
  
  METHODS
  Angiogenin concentrations in the peritoneal fluid, as measured by ELISA.
  
  
  RESULTS
  Angiogenin concentration in the peritoneal fluid was markedly elevated in the endometriosis patients (median 515 ng/mL, interquartile range 151-1763 ng/mL) compared with the cystadenoma (control) patients (195 ng/mL, 98-324 ng/mL), with values correlating with the extent of the disease. No significant differences between the proliferative phase and the secretory phase were observed in either the controls or the endometriosis patients.
  
  
  CONCLUSIONS
  The inflammation associated with endometriosis, through increasing levels of peritoneal fluid angiogenin, might promote angiogenesis for progression of the disease and correlate with the extent of the disorder.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medicine, Nagoya, Japan. og.n.suz@med.nagoya-cu.ac.jp
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzumori
authors.forename: Xaio Xi
authors.initials: XX
authors.lastname: Zhao
authors.forename: Kaoru
authors.initials: K
authors.lastname: Suzumori
mesh_terms: D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D001202:Ascitic Fluid / Q000378:metabolism*; D015331:Cohort Studies; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D010535:Laparoscopy; D007813:Laparotomy; D008597:Menstrual Cycle; D008875:Middle Aged; D009994:Osmolar Concentration; D012189:Retrospective Studies; D012259:Ribonuclease, Pancreatic / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D043925:Angiogenesis Inducing Agents; C046366:angiogenin; D012259:Ribonuclease, Pancreatic