title: Synthesis of novel substituted tetrazoles having antifungal activity.
abstract: In an effort to find potent antifungal agents, a variety of triazole derivatives with a 5-substituted tetrazole structure 6, 7, 12 and 14 were prepared and evaluated for antifungal activity against Candida spp., Cryptococcus neoformans, and Aspergillus spp. in vitro. The location of the methyl group at the C-3 of compounds 12 and 14 has been demonstrated to be a key structural element of antifungal potency.
authors.affiliation: Medicinal Chemistry Division, New Chemical Entity Research, Lupin Research Park, 46/47 A, At Village Nande, Taluka Mulshi, Pune 411 042, Maharashtra, India.
authors.forename: Ram Shankar
authors.initials: RS
authors.lastname: Upadhayaya
authors.forename: Sanjay
authors.initials: S
authors.lastname: Jain
authors.forename: Neelima
authors.initials: N
authors.lastname: Sinha
authors.forename: Nawal
authors.initials: N
authors.lastname: Kishore
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chandra
authors.forename: Sudershan K
authors.initials: SK
authors.lastname: Arora
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D013777:Tetrazoles