title: Screening for trisomy 21 in Flanders: a 10 years review of 40.490 pregnancies screened by maternal serum.
abstract: OBJECTIVE
  To evaluate maternal serum screening for trisomy 21 (MSS) in Flanders between 1992 and 2002.
  
  
  METHODS
  Data of a large database on the results of MSS, nuchal translucency (NT) and pregnancy outcome were analysed retrospectively.
  
  
  RESULTS
  Despite an excellent performance of second trimester MSS at a maternal age > or = 35 years (94.4% detection rate (DR) of trisomy 21 at a false positive rate (FPR) of 22.4%), the proportion of patients above 35 years of age in the study population was significantly lower than in the Flemish general pregnant population (5.5% versus 8.9%, P < 0.001). In the population screened by MSS and NT, the DR of second trimester MSS at a 5% FPR was 44.4%, which was lower than 66.6% in the population screened by MSS without NT. When nine trisomy 21-affected pregnancies were compared to 3265 normal pregnancies, the mean NT-MoM values were not significantly different (1.16 +/- 0.89 versus 1.00 +/- 0.46, P > 0.05). Both the findings comply to a sequential screening practice where second trimester MSS is only performed after a normal measurement of NT in the first trimester.
  
  
  CONCLUSIONS
  In Flanders, the uptake of second trimester maternal serum screening is low in women aged 35 years or more. Its screening performance decreased after the introduction of sequential screening.
authors.affiliation: Department of Obstetrics and Gynaecology, Ziekenhuis Oost Limburg, Genk B-3600, Belgium. wilfried.gyselaers@zol.be
authors.forename: Wilfried J A
authors.initials: WJ
authors.lastname: Gyselaers
authors.forename: Annie J
authors.initials: AJ
authors.lastname: Vereecken
authors.forename: Eric J H
authors.initials: EJ
authors.lastname: Van Herck
authors.forename: Dany P L
authors.initials: DP
authors.lastname: Straetmans
authors.forename: Guy E I
authors.initials: GE
authors.lastname: Martens
authors.forename: Eric T M
authors.initials: ET
authors.lastname: de Jonge
authors.forename: Willem U A M
authors.initials: WU
authors.lastname: Ombelet
authors.forename: Jan G
authors.initials: JG
authors.lastname: Nijhuis
mesh_terms: D000328:Adult; D001530:Belgium; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D009426:Netherlands; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal