Surfactant protein A and D (SP-A, AP-D) levels in patients with septic ARDS.
The levels of surfactant protein-A (SP-A) and surfactant protein-D (SP-D) in the serum of patients with septic acute respiratory distress syndrome (ARDS) were determined. Patients with sepsis without ARDS were examined as controls. The mean serum SP-A level in the former group was 37.6 +/- 16.2 ng/ml and in the latter group was 31.8 +/- 9.6 ng/ml. The difference between the two groups was not statistically significant. The maximum serum SP-D level was 83.0 +/- 33.9 ng/ml in the control group of patients without ARDS, and 476.3 +/- 391.2 ng/ml in the patients with ARDS. The level in the latter population was significantly higher than that in the former population. No significant correlation was observed between the SP-A and SP-D levels. These results suggest that the serum SP-D levels may serve as a good diagnostic indicator of ARDS in patients with sepsis.
Endo
Shigeatsu
S
Department of Critical Care Medicine, Iwate Medical University, 19-1 Uchimaru, Morioaka 0202-8505, Japan. sendo@iwate-med.ac.jp
Sato
Nobuhiro
N
Nakae
Hajime
H
Yamada
Yasuhiko
Y
Makabe
Hideyuki
H
Abe
Hajimu
H
Imai
Satoko
S
Wakabayashi
Go
G
Inada
Katsuya
K
Sato
Shigehiro
S
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D037662:Pulmonary Surfactant-Associated Protein A / Q000378:metabolism*; D037663:Pulmonary Surfactant-Associated Protein D / Q000378:metabolism*; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000378:metabolism*; D018805:Sepsis / Q000150:complications / Q000378:metabolism*
D015415:Biomarkers; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D