Cancer immunotherapy with chemoattractant peptides.
The chemokine/chemokine receptor network is an essential part of an intricate system of immunosurveillance and homeostasis, it promotes or suppresses neovascularization, affects and regulates directly or indirectly growth and metastasis of malignant cells. Numerous studies have been conducted to harness this network as therapeutic agents for cancer to redress the chemokine balance and control angiogenesis and tumour growth and metastasis. Second generation of immunotherapeutics and chemoattractant-based vaccines use chemokines and chemoattractant peptides to elicit antitumor immunity by a specific targeting and modulating subsets of effector leukocytes, including professional antigen presenting cells.
Coscia
Marta
M
Laboratorio di Ematologia Oncologica, Divisione di Ematologia dell'Universita' di Torino, CeRMS, Azienda Ospedaliera San Giovanni Battista, Torino, Italy.
Biragyn
Arya
A
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000627:therapeutic use*; D002465:Cell Movement / Q000276:immunology; D018925:Chemokines / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D019707:Receptors, Chemokine / Q000378:metabolism
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D018925:Chemokines; D019707:Receptors, Chemokine