title: Laparoscopic ovarian drilling as first line of treatment in infertile women with polycystic ovary syndrome.
abstract: Laparoscopic ovarian drilling (LOD) is used as a first line of treatment, as a second line of treatment after patients have proved resistant to clomiphene or as a third line of treatment after failed ovulation induction with gonadotropins. We present the postoperative pregnancy rates of 57 women to evaluate a potential optimal time of LOD together with the other treatment regimens of infertile women with polycystic ovary syndrome (PCOS). Data on the preoperative and operative treatment, and background data were evaluated for their influence on pregnancy rates. The pregnancy rate was 61% among women with PCOS who had LOD. No difference was found in the clinical data between the women who became pregnant and those who did not. Likewise, no difference was found between the women who had pre- and/or postoperative medical ovulation treatment and those who had none. The median time to pregnancy after LOD was 135 days. LOD alone resolves infertility within 4-6 months in 50-60% of couples. A strategy with diagnostic laparoscopy and LOD as the first line of treatment of infertility in women with PCOS will shorten the time to pregnancy for many women, reduce the need for medical ovulation induction and enable diagnosis of those women with anatomic infertility, who can achieve pregnancy only by in vitro fertilization treatment.
authors.affiliation: Department of Gynecology and Obstetrics, Holstebro Hospital, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Cleemann
authors.forename: F F
authors.initials: FF
authors.lastname: Lauszus
authors.forename: B
authors.initials: B
authors.lastname: Trolle
mesh_terms: D002996:Clomiphene / Q000008:administration & dosage; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000601:surgery*; D010535:Laparoscopy; D010053:Ovary / Q000601:surgery*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013997:Time Factors
chemical_list: D002996:Clomiphene; D005640:Follicle Stimulating Hormone