Phenotype and natural killer cell sensitivity of a radiation-induced acute T-cell leukaemia (Roser leukaemia) in PVG rats.
A radiation-induced T-cell leukaemia [Roser leukaemia (RL)] in the rat was conditioned for growth in vitro by repeated in vivo-in vitro passages. This in vitro cell line, termed RL-T, maintained its leukaemia-inducing property when transferred to syngeneic PVG rats. It expresses several T-cell markers and the T-cell alpha/beta receptor-CD3 complex. RL-T, furthermore, expresses major histocompatibility complex (MHC) I antigens, both classical (RT1.A) and nonclassical (RT1.C), which makes it susceptible to killing by alloreactive natural killer cells in vitro.
Nestvold
J
J
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, NO-0317 Oslo, Norway.
Stokland
A
A
Naper
C
C
Rolstad
B
B
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005434:Flow Cytometry; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology*; D007953:Leukemia, Radiation-Induced / Q000276:immunology*; D015458:Leukemia, T-Cell / Q000276:immunology*; D008297:Male; D051381:Rats; D014407:Tumor Cells, Cultured
D015395:Histocompatibility Antigens Class I