title: Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias.
abstract: Overexpression of thymosin beta-10 (TB10) has been shown in rat thyroid transformed cell lines, and in human thyroid carcinoma tissues and cell lines. To investigate whether TB10 detection could be a valid tool in the diagnosis of human thyroid neoplasias, we extended the analysis of TB10 expression to a large number of thyroid hyperproliferative and neoplastic tissues using an immunohistochemical assay. Our analyses showed a TB10 positive staining in all human thyroid carcinomas particularly in the anaplastic histotypes, whereas no TB10 immunostaining was observed in normal thyroid, in adenomas and the majority of the goiters. These results suggest that the evaluation of TB10 gene expression may be considered a promising means of diagnosis of human thyroid hyperproliferative disorders.
authors.affiliation: Istituto dei Tumori di Napoli, Napoli, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Chiappetta
authors.forename: Francesca
authors.initials: F
authors.lastname: Pentimalli
authors.forename: Mario
authors.initials: M
authors.lastname: Monaco
authors.forename: Monica
authors.initials: M
authors.lastname: Fedele
authors.forename: Rosa
authors.initials: R
authors.lastname: Pasquinelli
authors.forename: Giovanna Maria
authors.initials: GM
authors.lastname: Pierantoni
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Ribecco
authors.forename: Giovanni
authors.initials: G
authors.lastname: Santelli
authors.forename: Daniela
authors.initials: D
authors.lastname: Califano
authors.forename: Luciano
authors.initials: L
authors.lastname: Pezzullo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fusco
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D013947:Thymosin / Q000096:biosynthesis* / Q000235:genetics; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
chemical_list: D013947:Thymosin; C039302:thymosin beta(10)