Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain.
The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.
Schmidt
Boris
B
Institute for Organic Chemistry and Biochemistry, Darmstadt Technical University, Petersenstr. 22, D-64287 Darmstadt, Germany. schmibo@oc.chemie.tu-darmstadt.edu
Jiricek
Jan
J
Titz
Alexander
A
Ye
Guofeng
G
Parang
Keykavous
K
D003300:Copper / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D010848:Picolinic Acids / Q000737:chemistry / Q000378:metabolism*; D018909:src Homology Domains
D008024:Ligands; D010455:Peptides; D010848:Picolinic Acids; D003300:Copper; C004860:dipicolinic acid