The effect of different dialysis membranes on oxidative stress and selenium status.
BACKGROUND
Oxidative stress is an important risk factor for the development and progression of several complications in hemodialysis patients. The aim of this study was to evaluate the effects of two different dialysis membranes on oxidative stress and selenium status.


METHODS
Forty long-term dialysis patients and 20 age-matched healthy controls were enrolled into our study. Serum malondialdehyde (MDA) and selenium (Se) concentrations, and glutathione peroxidase (GSH-Px) activities were determined before and after hemodialysis (HD) using a hemophan (H) or a polysulfone (PS) membrane.


RESULTS
MDA levels in the HD patients were significantly higher than those in the control group (p < 0.001). GSH-Px activity and selenium concentrations were significantly lower in HD patients compared to the control group (p < 0.001). MDA levels were significantly increased (p < 0.05); GSH-Px activity and selenium concentrations were significantly reduced (p < 0.001) in the PS membrane group compared to H membrane group after HD.


CONCLUSIONS
Comparing with H membrane, PS membrane caused more oxidative stress and lower levels of Se in HD patients.
Yavuz
Ozlem
O
Department of Medical Biochemistry, Duzce School of Medicine, Abant Izzet Baysal University, 81620 Konuralp-Duzce, Turkey. o_yavuz@yahoo.com
Bicik
Zerrin
Z
Cinar
Yelda
Y
Guney
Yildiz
Y
Guler
Selver
S
D000328:Adult; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D035061:Control Groups; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008566:Membranes / Q000737:chemistry* / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D011108:Polymers / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D012643:Selenium / Q000097:blood*; D013450:Sulfones / Q000737:chemistry
D011108:Polymers; D017382:Reactive Oxygen Species; D013450:Sulfones; C054645:Hemophan; C017662:polysulfone P 1700; D008315:Malondialdehyde; D002482:Cellulose; D005979:Glutathione Peroxidase; D012643:Selenium