Phosphatases join kinases in DNA-damage response pathways.
An inappropriate imbalance of kinase and phosphatase activities could be deleterious to cellular processes such as proliferation. Cellular responses to DNA damage use signal-transduction pathways involving phosphorylation events, and such modifications must be reversible to make these responses transient, rather than permanent, events. Three recent articles describe roles for two phosphatases in signaling pathways that are activated after DNA damage.
Bakkenist
Christopher J
CJ
Department of Hematology and Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.
Kastan
Michael B
MB
D004249:DNA Damage / Q000502:physiology*; D008954:Models, Biological; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology*; D010770:Phosphotransferases / Q000502:physiology*; D012568:Schizosaccharomyces / Q000201:enzymology / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases