title: Electrogastrography differentiates reflux disease with or without dyspeptic symptoms.
abstract: Many patients with gastroesophgeal reflux disease (GERD) may also have overlapping symptoms of dyspepsia. This study was to examine if GERD patients could be separated into meaningful groups based on their gastric myoelectrical characteristics. The study included 20 GERD patients with dyspeptc symptoms (GERD+) and 17 patients with GERD. Gastric myoelectrical activity was assessed using cutaneous electrodes to record electrogastrograms (EGGs). The GERD+ patients ingested smaller volumes of water compared to patients with GERD (P < 0.05). At baseline, the percentage of gastric myoelectrical power in the normal 3-cpm range was significantly less in patients with GERD+ compared with the GERD subjects (P = 0.01). Power in the bradygastria range was significantly greater in patients with GERD+ (P = 0.005). The GERD+ group had a significant increase in the percentage of power in the tachygastria range later after ingesting the water load (P < 0.01). In conclusion, this study has shown that more gastric dysrhythmias were detected in the GERD+ patients accompanied with altered perception of stomach fullness.
authors.affiliation: Department of Medicine, Buddhist Tzu Chi General Hospital and University School of Medicine, Hualien 970, Taiwan. clchen@tzuchi.org.tw
authors.forename: Chien-Lin
authors.initials: CL
authors.lastname: Chen
authors.forename: Hsien-Hong
authors.initials: HH
authors.lastname: Lin
authors.forename: Lu-Chin
authors.initials: LC
authors.lastname: Huang
authors.forename: Shih-Che
authors.initials: SC
authors.lastname: Huang
authors.forename: Tso-Tsai
authors.initials: TT
authors.lastname: Liu
mesh_terms: D000328:Adult; D004415:Dyspepsia / Q000150:complications / Q000503:physiopathology*; D004576:Electromyography / Q000379:methods*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D013270:Stomach / Q000503:physiopathology*