Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer.
OBJECTIVE
Investigation of possible effects of aqueous extract of Urtica dioica leaves on adenosine deaminase activity in prostate tissue from patients with prostate cancer.


METHODS
Ten prostate tissues from patients with pathologically proven localized prostate cancer (Gleason scores 4 to 7) were used in the study. In the tissues, ADA activities with and without preincubation with different amounts of Urtica dioica extracts were performed.


RESULTS
Aqueous extract of Urtica dioica results in significant inhibition on adenosine deaminase (ADA) activity of prostate tissue.


CONCLUSIONS
ADA inhibition by Urtica dioica extract might be one of the mechanisms in the observed beneficial effect of Urtica dioica in prostate cancer.
Durak
Ilker
I
Ankara University, School of Medicine, Department of Biochemistry, Ankara, Turkey. ilker_durak@yahoo.com
Biri
Hasan
H
Devrim
Erdinç
E
Sözen
Sinan
S
Avci
Aslihan
A
D000243:Adenosine Deaminase / Q000187:drug effects* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000201:enzymology*; D014407:Tumor Cells, Cultured; D026982:Urtica dioica / Q000737:chemistry*
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D004247:DNA; D000243:Adenosine Deaminase