title: Dipeptide binding in water by a de novo designed guanidiniocarbonylpyrrole receptor.
abstract: A new dipeptide receptor 9, which was designed de novo based on theoretical calculations, efficiently binds dipeptides in water with Kass > 104 M-1 by a combination of ion pairing and hydrogen bonds as can be shown by UV-titration and NMR experiments.
authors.affiliation: Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Wuerzburg, Germany. schmuck@chemie.uni-wuerzburg.de
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
authors.forename: Lars
authors.initials: L
authors.lastname: Geiger
mesh_terms: D004151:Dipeptides / Q000737:chemistry*; D019791:Guanidine / Q000031:analogs & derivatives* / Q000737:chemistry; D007700:Kinetics; D008958:Models, Molecular; D011485:Protein Binding; D011758:Pyrroles / Q000737:chemistry*; D018000:Receptors, Peptide / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D004151:Dipeptides; D011758:Pyrroles; D018000:Receptors, Peptide; D014867:Water; D019791:Guanidine