title: Endothelial dysfunction in rheumatoid arthritis: influence of HLA-DRB1 alleles.
abstract: Cardiovascular disease is the commonest cause of premature mortality in rheumatoid arthritis (RA) patients. Vascular endothelial injury is the primary event in atherosclerosis. It has been associated with endothelial dysfunction. We have recently observed that actively treated RA patients had endothelial dysfunction. HLA-DRB1 shared epitope alleles, in particular HLA-DRB1*0404, seem to be implicated in the development of endothelial dysfunction. These results underline the influence of genetic factors in the risk of atherosclerosis in RA patients.
authors.affiliation: Rheumatology Division, Hospital Xeral-Calde, Lugo 27004, Spain. miguelaggay@hotmail.com
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Gonzalez-Gay
authors.forename: Carlos
authors.initials: C
authors.lastname: Gonzalez-Juanatey
authors.forename: William E
authors.initials: WE
authors.lastname: Ollier
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D012307:Risk Factors; D014664:Vasodilation
chemical_list: D000939:Epitopes; D006684:HLA-DR Antigens