title: Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness.
abstract: Excessive daytime sleepiness, hallucinations and REM sleep behavior disorder are symptoms reported in both dementia with Lewy bodies (DLB) and narcolepsy. Considering the demonstration of low hypocretin-1/orexin A levels in the cerebrospinal fluid (CSF) of most patients with narcolepsy, we hypothesized the presence of a deficient hypocretinergic transmission in DLB. Hypocretin-1 was tested in the CSF of 10 DLB patients. Levels were found to be in the normal range (mean 521 pg/ml, range 382-667) when compared to controls (n = 20, mean 497 pg/ml, range 350-603) and Alzheimer's disease patients (n = 7, mean 474 pg/ml, range 333-564). In DLB, excessive daytime sleepiness, hallucinations and REM sleep behavior may occur in the absence of a detectable hypocretin deficiency.
authors.affiliation: Neurology Department, University Hospital, Zurich, Switzerland.
authors.forename: Christian R
authors.initials: CR
authors.lastname: Baumann
authors.forename: Yves
authors.initials: Y
authors.lastname: Dauvilliers
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mignot
authors.forename: Claudio L
authors.initials: CL
authors.lastname: Bassetti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006970:Disorders of Excessive Somnolence / Q000134:cerebrospinal fluid* / Q000150:complications; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D020961:Lewy Body Disease / Q000134:cerebrospinal fluid* / Q000150:complications; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D017286:Polysomnography / Q000379:methods; D011863:Radioimmunoassay / Q000379:methods
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins