title: The inhibition of superoxide anion generation by neutrophils from Viscum articulactum.
abstract: Two new flavanones, (2S)-pinocembrin 7-O-[beta-D-apiosyl(1-->2)]-beta-D-glucoside (1), and (2S)-pinocembrin 7-O-[cinnamoyl(1-->5)-beta-D-apiosyl(1-->2)]-beta-D-glucoside (2) together with eighteen known compounds, which include five known flavanones, nine benzenoids, one inositol and three triterpenoids, were isolated and characterized from fresh Viscum articulactum. Structures of new compounds were determined by spectral analysis. Among them, oleanolic acid (18) showed a significant inhibition effect on superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taiwan. ylleu@mail.cgu.edu.tw
authors.forename: Yann-Lii
authors.initials: YL
authors.lastname: Leu
authors.forename: Shih-Ming
authors.initials: SM
authors.lastname: Kuo
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Shau-Ting
authors.initials: ST
authors.lastname: Chiu
mesh_terms: D000293:Adolescent; D000328:Adult; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D013481:Superoxides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D028181:Viscum
chemical_list: D010936:Plant Extracts; D013481:Superoxides