Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes.
Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.
Bicknell
Katrina A
KA
Cardiovascular Research Group, School of Pharmacy, The University of Reading, P.O. Box 228, Whiteknights, Reading, Berkshire RG6 6AJ, UK.
Coxon
Carmen H
CH
Brooks
Gavin
G
D000818:Animals; D016203:CDC2 Protein Kinase / Q000502:physiology*; D049109:Cell Proliferation; D019926:Cyclin B / Q000502:physiology*; D056744:Cyclin B1; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D008297:Male; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar
C534701:Ccnb1 protein, rat; D019926:Cyclin B; D056744:Cyclin B1; D016203:CDC2 Protein Kinase