Markedly asymmetrical parkinsonism as a leading feature of adult-onset Huntington's disease.
We report on a 28-year-old man who presented with right hand tremor, bradykinesia, and rigidity of his right side extremities. Our case report emphasizes that markedly asymmetrical parkinsonism can be an initial presentation of adult-onset Huntington's disease (HD), and different clinical presentations can be observed in members of an individual HD family with the same CAG repeat length.
Wang
Shih-Ching
SC
Second Department of Neurology, Chang Gung Memorial Hospital, LinKou Medical Center, Taipei, Taiwan.
Lee-Chen
Guey-Jen
GJ
Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.
Wang
Cheng-Kung
CK
Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.|Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.
Chen
Chiung-Mei
CM
Second Department of Neurology, Chang Gung Memorial Hospital, LinKou Medical Center, Taipei, Taiwan.
Tang
Lok-Ming
LM
Second Department of Neurology, Chang Gung Memorial Hospital, LinKou Medical Center, Taipei, Taiwan.
Wu
Yih-Ru
YR
Second Department of Neurology, Chang Gung Memorial Hospital, LinKou Medical Center, Taipei, Taiwan.
D000328:Adult; D000483:Alleles; D000978:Antiparkinson Agents / Q000627:therapeutic use; D002230:Carbidopa / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D004338:Drug Combinations; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000188:drug therapy; D010375:Pedigree; D012720:Severity of Illness Index
D000978:Antiparkinson Agents; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa