L-arginine metabolism during interaction of Trypanosoma cruzi with host cells.
Trypanosoma cruzi invades a diversity of nucleated cells in the mammalian host. Macrophages are among the first cells to be parasitized and, after activation by inflammatory stimuli, they participate in the control of infection. However, some parasites manage to evade the immune response and establish a chronic infection in differentiated cells. L-arginine is located at the crossroads of divergent routes that produce metabolites, including nitric oxide and polyamines, which influence the outcome (i.e. resolution or progression) of infection. This article discusses the fate and actions of L-arginine-derived biomolecules formed both in the host and in the parasite during T. cruzi-host-cell interactions.
Peluffo
Gonzalo
G
Department of Biochemistry and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Avda. General Flores 2125, 11800 Montevideo, Uruguay.
Piacenza
Lucía
L
Irigoín
Florencia
F
Alvarez
María Noel
MN
Radi
Rafael
R
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D015317:Biogenic Polyamines / Q000378:metabolism; D014355:Chagas Disease / Q000378:metabolism* / Q000469:parasitology; D006790:Host-Parasite Interactions / Q000502:physiology; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000469:parasitology; D009569:Nitric Oxide / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000378:metabolism* / Q000469:parasitology
D015317:Biogenic Polyamines; D009569:Nitric Oxide; D001120:Arginine