title: Clinical, haematological and histomorphological profile of adult myelodysplastic syndrome. Study of 96 cases in a single institute.
abstract: Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell disorders characterised by ineffective and dyspoietic haematopoiesis. The natural history of these disorders is variable and ranges from a chronic to a rapid course towards leukaemic progression. Certain shortcomings have been encountered in the French-American-British (FAB) classification over the years, and therefore there is a need for an alternative method of classification. In 1999, the WHO published a revised classification of MDS. In the present study, we have analysed the clinical, haematological and histomorphological features in 96 cases of primary MDS seen in the department of haematology at the All India Institute of Medical Sciences (AIIMS) over a 6-yr period (1996-2001). Both FAB and WHO classifications have been incorporated and the Bournemouth scoring system applied in each case at presentation. The Bournemouth scoring system, in the absence of a cytogenetic study, offers a good prognostication and long-term survival estimate.
authors.affiliation: Department of Haematology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: T
authors.initials: T
authors.lastname: Chatterjee
authors.forename: A
authors.initials: A
authors.lastname: Dixit
authors.forename: M
authors.initials: M
authors.lastname: Mohapatra
authors.forename: S
authors.initials: S
authors.lastname: Tyagi
authors.forename: P K
authors.initials: PK
authors.lastname: Gupta
authors.forename: P
authors.initials: P
authors.lastname: Mishra
authors.forename: M
authors.initials: M
authors.lastname: Bhattacharya
authors.forename: A S
authors.initials: AS
authors.lastname: Karan
authors.forename: H P
authors.initials: HP
authors.lastname: Pati
authors.forename: R
authors.initials: R
authors.lastname: Saxena
authors.forename: V P
authors.initials: VP
authors.lastname: Choudhry
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001773:Blood Cells / Q000473:pathology; D001856:Bone Marrow Examination; D002965:Classification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D012720:Severity of Illness Index; D016019:Survival Analysis