[Diagnostic value of interleukin-10 and interleukin-6 in the vitreous of intraocular malignant lymphoma patients].
OBJECTIVE
Recent data suggest that the concentration of interleukin-10 (IL-10) is higher than that of interleukin-6 (IL-6) in the vitreous of eyes of patients with non-Hodgkin's lymphoma. In this study, we evaluated the utility of measuring intravitreal IL-10 and IL-6 concentrations in the diagnosis of intraocular lymphoma.


METHODS
Specimens of undiluted vitreous were collected at the time of pars plana vitrectomy and IL-10 and IL-6 concentrations were determined. Vitreous specimens were obtained from 5 patients with suspected intraocular lymphoma and 10 patients with uveitis presumed to be unrelated to a neoplasm.


RESULTS
In all 5 patients eventually diagnosed with intraocular lymphoma, the vitreous IL-10 concentration ranged from 3,040 to 11,200 pg/ml, and was higher than the vitreous IL-6 concentration in all cases. In 9 of the 10 patients with uveitis, the vitreous IL-10 concentrations ranged from less than 2 to 97 pg/ml, with an IL-10/IL-6 ratio of less than 0.11. However, in the remaining case diagnosed as uveitis of unknown etiology, the vitreous IL-10/IL-6 ratio was greater than 1.


CONCLUSIONS
Our data suggest that the measurement of vitreous IL-10 concentrations would aid in the diagnosis of intraocular lymphoma.
Hirakata
Akito
A
Department of Ophthalmology, Kyorin University School of Medicine, Mitaka, Japan.
Inami
Tatsuya
T
Saito
Maki
M
Okada
Annabelle A
AA
Hida
Tetsuo
T
Ishida
Susumu
S
Shinoda
Kei
K
Homori
Masashi
M
Kawano
Koichi
K
Suzuki
Saburosuke
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014822:Vitreous Body / Q000737:chemistry* / Q000473:pathology
D014408:Biomarkers, Tumor; D015850:Interleukin-6; D016753:Interleukin-10