title: [Prognostic value of lymphatic vessel and neural invasion in colorectal carcinoma].
abstract: OBJECTIVE
  The paradoxical evolution of approximately one third of patients with colorectal cancer cataloged in Dukes stages B and C demonstrates the necessity of make useful other prognostic criteria. The presence of neural and lymphatic invasion of tumor cells was correlated with the prognosis of patients submitted to radical operation.
  
  
  METHODS
  We performed a retrospective study on 320 patients with colo-rectal carcinoma, with mean age 58 years and 199 (62.2%) females. Neural invasion was assessed as positive if cancer cells infiltration into the perineurium or neural fasciculus was detected at the leading point. Lymphatic invasion was defined by cancer cells infiltration into a space limited by endothelium without muscular or elastic fibers. Those variable were associated to the original classification of Dukes.
  
  
  RESULTS
  Lymphatic and neural invasion was demonstrated in 14.1% and 15% of 320 operation specimens respectively. The most frequent site of lymphatic and neural invasion was the rectum. The overall survival was 25% in the presence of neural invasion and 64% without neural invasion (p<.01). At the presence of lymphatic invasion, the overall survivals were 26.7% and 63.3%, respectively (p <0.01). The overall survival was always worse in the presence of the invasion neural, independently of the compromising or not of the lymphonodes. In patients of free lymphonodes, the lymphatic invasion identified sub-groups of sick with worse prognosis. The presence of these variable it identified in patients with tumors Dukes B, sub-group of worse prognosis.
  
  
  CONCLUSIONS
  Neural and lymphatic invasion are important ways of spread of colorectal cancer and the presence of both is associated with worse prognosis.
authors.affiliation: Pós-graduação em Gastroenterologia Cirúrgica do Instituto de Assistência Médica ao Servidor Público Estadual e no Serviço de Gastroenterologia Cirúrgica do Hospital do Servidor Público Estadual de São Paulo-Francisco Morato de Oliveira, São Paulo, SP.
authors.forename: Antonio Paulo
authors.initials: AP
authors.lastname: Durante
authors.forename: Sansom Henrique
authors.initials: SH
authors.lastname: Bromberg
authors.forename: Elci
authors.initials: E
authors.lastname: Barreto
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cappellano
authors.forename: Antonio Claudio
authors.initials: AC
authors.lastname: de Godoy
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D042601:Lymphatic Vessels / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010502:Perineum / Q000294:innervation / Q000473:pathology; D012189:Retrospective Studies; D016019:Survival Analysis