title: Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain.
abstract: The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.
authors.affiliation: Institute for Organic Chemistry and Biochemistry, Darmstadt Technical University, Petersenstr. 22, D-64287 Darmstadt, Germany. schmibo@oc.chemie.tu-darmstadt.edu
authors.forename: Boris
authors.initials: B
authors.lastname: Schmidt
authors.forename: Jan
authors.initials: J
authors.lastname: Jiricek
authors.forename: Alexander
authors.initials: A
authors.lastname: Titz
authors.forename: Guofeng
authors.initials: G
authors.lastname: Ye
authors.forename: Keykavous
authors.initials: K
authors.lastname: Parang
mesh_terms: D003300:Copper / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D010848:Picolinic Acids / Q000737:chemistry / Q000378:metabolism*; D018909:src Homology Domains
chemical_list: D008024:Ligands; D010455:Peptides; D010848:Picolinic Acids; D003300:Copper; C004860:dipicolinic acid