title: Elevated resistive index in the hepatic artery as a predictor of fulminant hepatic failure in patients with acute viral hepatitis: a prospective study using Doppler ultrasound.
abstract: To assess the sensitivity and specificity of the resistive index of the hepatic artery, which is related to the vascular resistance of the artery, for the prediction of fulminant hepatic failure, we performed Doppler ultrasonography examinations on the hepatic arteries of 72 patients with acute viral hepatitis (25 of whom developed fulminant hepatic failure and 47 of whom recovered without developing fulminant hepatic failure) as well as the hepatic arteries of age- and sex-matched controls. The mean resistive index of the hepatic arteries in patients who developed fulminant hepatic failure was significantly larger than that of patients who recovered without developing fulminant hepatic failure (P < 0.01). When a resistive index cutoff level of 0.74 was used, an 84% sensitivity and a 94% specificity were obtained for the prediction of fulminant hepatic failure. An elevated resistive index of the hepatic artery may be useful for predicting the patient's clinical outcome and determining the need for a liver transplantation in patients with acute viral hepatitis.
authors.affiliation: Gastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, Japan. k_tanaka@urahp.yokohama-cu.ac.jp
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kazushi
authors.initials: K
authors.lastname: Numata
authors.forename: Manabu
authors.initials: M
authors.lastname: Morimoto
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Shirato
authors.forename: Satoru
authors.initials: S
authors.lastname: Saito
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
authors.forename: Shinju
authors.initials: S
authors.lastname: Arata
authors.forename: Mitsugi
authors.initials: M
authors.lastname: Sugiyama
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D017093:Liver Failure / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance / Q000502:physiology