title: A new amidrazone derivative with antimycobacterial activity.
abstract: Of a series of pyridine-2-carboxamidrazone derivatives with activity against mycobacteria, the N(1)-[4-(1,1-dimethylpropyl)benzylidene] derivative reported here, C(18)H(22)N(4), is one of the most active. The predicted E isomer about the C11=N12 double bond is confirmed and intramolecular hydrogen bonding involving both amino H atoms helps to keep the molecule flat. The same donor and acceptor atoms also form intermolecular hydrogen bonds.
authors.affiliation: Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham B4 7ET, England.
authors.forename: D C
authors.initials: DC
authors.lastname: Billington
authors.forename: P R
authors.initials: PR
authors.lastname: Lowe
authors.forename: D L
authors.initials: DL
authors.lastname: Rathbone
authors.forename: C H
authors.initials: CH
authors.lastname: Schwalbe