Unexpected conserved non-coding DNA blocks in mammals.
The significance of non-coding DNA is a longstanding riddle in the study of molecular evolution. Using a comparative genomics approach, Dermitzakis and colleagues have recently shown that at least some non-coding sequence, frequently ignored as meaningless noise, might bear the signature of natural selection. If functional, it could mark a turning point in the way we think about the evolution of the genome.
Gaffney
Daniel J
DJ
Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, United Kingdom. Daniel.Gaffney@ed.ac.uk
Keightley
Peter D
PD
D000818:Animals; D019295:Computational Biology; D017124:Conserved Sequence; D021901:DNA, Intergenic / Q000235:genetics*; D019143:Evolution, Molecular; D023281:Genomics; D006801:Humans; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods
D021901:DNA, Intergenic