title: Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris.
abstract: A polysaccharide from the water extract of cultured Cordyceps militaris was isolated through ethanol precipitation, deproteination and gel-filtration chromatography. Their molecular weight was determined using gel-filtration chromatography. The structure of polysaccharide CPS-1 was elucidated by sugar analysis, Smith degradation, IR and 13C-NMR spectroscopy. CPS-1 was shown to possess a significant antiinflammatory activity and suppressed the humoral immunity in mice but had no significant effects on the cellular immunity and the non-specific immunity.
authors.affiliation: Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 510632, Guangzhou, China. rongminyu99@hotmail.com
authors.forename: Rongmin
authors.initials: R
authors.lastname: Yu
authors.forename: Liyan
authors.initials: L
authors.lastname: Song
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Wen
authors.initials: W
authors.lastname: Bin
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Yihang
authors.initials: Y
authors.lastname: Wu
authors.forename: Wencai
authors.initials: W
authors.lastname: Ye
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
mesh_terms: D019342:Acetic Acid; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects*; D032661:Cordyceps; D003436:Croton Oil; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006461:Hemolysis; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010587:Phagocytosis / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D011134:Polysaccharides; D003436:Croton Oil; D019342:Acetic Acid