title: Annexin-actin interactions.
abstract: The actin cytoskeleton is a malleable framework of polymerised actin monomers that may be rapidly restructured to enable diverse cellular activities such as motility, endocytosis and cytokinesis. The regulation of actin dynamics involves the coordinated activity of numerous proteins, among which members of the annexin family of Ca2+- and phospholipid-binding proteins play an important role. Although the roles of annexins in actin dynamics are not understood at a mechanistic level, annexins have the requisite properties to integrate Ca2+-signaling with actin dynamics at membrane contact sites. In this review we discuss the current state of knowledge on this topic, and consider how and where annexins may fit into the complex molecular machinery that regulates the actin cytoskeleton.
authors.affiliation: Division of Cell Biology, Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hayes
authors.forename: Ursula
authors.initials: U
authors.lastname: Rescher
authors.forename: Volker
authors.initials: V
authors.lastname: Gerke
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Moss
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D017302:Annexins / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular
chemical_list: D000199:Actins; D017302:Annexins