Transgenic mice as an in vivo model of lymphomagenesis.
This review covers multiple data obtained on genetically modified mice that help to elucidate various intricate molecular mechanisms of lymphomagenesis in humans. We are in a "golden age" of mouse genetics. The mouse is by far the most accessible mammalian system physiologically similar to humans. Transgenic mouse models have illuminated how different genes contribute to human lymphomagenesis. Multiple experiments with transgenic mice have not only confirmed the data obtained for human lymphomas but also gave additional evidence for the role of some genes and cooperative participation of their products in the development of human lymphomas. Genes and gene networks detected on transgenic mice can successfully serve as molecular targets for tumor therapy. This review demonstrates the extraordinary possibilities of transgenic technology, which is presently one of the readily available, efficient, and accurate tools to solve the problem of cancer.
Tarantul
V Z
VZ
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia.
D000818:Animals; D047390:Casein Kinase II; D016207:Cytokines / Q000235:genetics; D004260:DNA Repair; D004195:Disease Models, Animal; D016147:Genes, Tumor Suppressor; D005814:Genes, Viral; D018816:Genes, cdc; D016259:Genes, myc; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009857:Oncogenes; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D019076:Transgenes
D016207:Cytokines; D011956:Receptors, Cell Surface; D014157:Transcription Factors; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases