title: In vivo proton magnetic resonance spectroscopy in the evaluation of the endometrium.
abstract: BACKGROUND
  The purposes of this study were to compare proton magnetic resonance (MR) spectroscopic evaluation of the endometrium with histology obtained by endometrial biopsy in women undergoing diagnostic curettage and to determine whether screening with MR spectroscopy (MRS) might be useful in the evaluation of the endometrium.
  
  
  METHODS
  Twenty-three consecutive women who were scheduled for endometrial biopsy were included in the study. The women were evaluated by MRS, performed immediately before the endometrial biopsy. The MRS results were compared with the histological findings obtained from the endometrial biopsy.
  
  
  RESULTS
  All of the cases were proven by pathological examination, and their diagnoses were secretory endometrium (11 cases), proliferative endometrium (seven cases) and disordered proliferative endometrium (five cases). The characteristically obtained signals of choline (Cho) and lipid were detected in all subjects in the secretory endometrium group. In the same group, eight patients showed lactate signals and six showed creatine (Cr) signals. In the disordered proliferative endometrium group, four patients showed lipid plus Cho signals. Two patients in the same group demonstrated both lactate and Cr signals. All patients in the proliferative endometrium group showed Cho signals, two patients demonstrated lactate plus Cho signals, and none of the patients in this group showed lipid and Cr signals.
  
  
  CONCLUSIONS
  Proton magnetic resonance spectra can register certain metabolic differences in human endometrium in its different stages.
authors.affiliation: Department of Radiology, Inonu University, School of Medicine, Malatya, Turkey.
authors.forename: Kaya
authors.initials: K
authors.lastname: Sarac
authors.forename: Onder
authors.initials: O
authors.lastname: Celik
authors.forename: Seyma
authors.initials: S
authors.lastname: Hascalik
authors.forename: Alpay
authors.initials: A
authors.lastname: Alkan
authors.forename: Bulent
authors.initials: B
authors.lastname: Mizrak
mesh_terms: D000328:Adult; D003475:Curettage; D004714:Endometrial Hyperplasia / Q000473:pathology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011237:Predictive Value of Tests