title: [Clinical study on effect of chuankezhi injection in treating children with bronchial asthma].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of chuankezhi injection to children with bronchial asthma.
  
  
  METHODS
  Sixty-eight children suffered from asthma and/or asthma complicated with allergic rhinitis were randomly divided into the treated group and the control group, who received treatment of chuankezhi injection and Ginkgo injection respectively. Clinical observation on daily-symptom scores, and lung functions as peak expiratory flow (PEF), and forced expiratory volume in one second (FEV1) were conducted.
  
  
  RESULTS
  After treatment the median of symptomatic scores in the treated group was 6.0 (M25-M75: 4.9-21.5) and that in the control group was 10.0 (M25-M75: 6.19-27.5), showing significant difference between groups; significant improvement was shown in the treated group, in which the PEF variance rate was reduced to 4.3 +/- 5.1%, while in the control group, it was 5.9 +/- 6.7%, the difference between the two groups was significant. Similar result also showed in comparison of FEV1 rate.
  
  
  CONCLUSIONS
  Chuankezhi is helpful in improving clinical symptoms, reducing PEF variance rate and enhancing lung function in children with bronchial asthma, so as to be benefit to the long-term stable alleviation of asthma.
authors.affiliation: Pediatric Department, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai (200025). lele750216@163.com
authors.forename: Jian-qin
authors.initials: JQ
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Shao
authors.forename: Wen-wei
authors.initials: WW
authors.lastname: Zhong
mesh_terms: D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D008517:Phytotherapy; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000188:drug therapy
chemical_list: D018927:Anti-Asthmatic Agents; D004365:Drugs, Chinese Herbal