[Schistosomal portal hypertension: influence of the portal blood flow in serum levels of hepatic enzymes].
OBJECTIVE
To evaluate relation between the portal blood flow and the laboratory hepatic screening in patients with schistosomal portal hypertension.


METHODS
Sixty-four patients with schistosomal portal hypertension had studied, being 19 not operated, 23 submitted to esophagogastric devascularization with splenectomy and 22 submitted to distal splenorenal shunt. Evaluated the laboratory hepatic screening through the dosage of albumin, aspartate aminotransferase, alanine aminotransferase, direct bilirubin and indirect bilirubin, alkaline phosphatase, gamma-glutamil transferase and prothrombin time. The portal flow was evaluated for Doppler. The results have been analyzed through linear regression, Pearson correlation coefficient, chi-square and one-way analysis of variance with Tukey's test.


RESULTS
It was proven that only gamma-glutamil transferase had significant correlation with the portal flow. In compare of the quartiles, also only gamma-glutamil transferase showed resulted significant, it was evidenced that the fourth quartile, that is bigger portal flow and formed in its majority for patients not operated, also was bigger average of gamma-glutamil transferase and significantly bigger value than first and the third quartiles.


CONCLUSIONS
1. The portal blood flow was bigger in patients that the serum level of GGT was bigger; 2. the gamma-glutamil transferase is the variable of the hepatic screening evaluation more representative of the portal flow influence in hepatic functional activity in patients with hepatosplenic schistosomiasis, and 3. probably, the different surgeries through hemodynamics modifications, are beneficial in to diminish the degree of cholestasis or in decrease the microssomal induction.
Alves
Antonio
A
Departamento de Medicina, Universidade Federal de Sergipe, Aracaju, SE. aalves@infonet.com.br
Fontes
Dercílio Alves
DA
de Melo
Valdinaldo Aragão
VA
Machado
Marcel Cerqueira C
MC
Cruz
Josilda Ferreira
JF
Santos
Egmond Alves Silva
EA
D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood / Q000201:enzymology* / Q000209:etiology; D008099:Liver / Q000098:blood supply / Q000201:enzymology*; D008875:Middle Aged; D011169:Portal Vein / Q000502:physiology*; D012039:Regional Blood Flow; D012189:Retrospective Studies; D012555:Schistosomiasis mansoni / Q000097:blood / Q000150:complications / Q000201:enzymology*; D005723:gamma-Glutamyltransferase / Q000097:blood* / Q000378:metabolism
D005723:gamma-Glutamyltransferase