title: Clonal stability of initial leukemia in a child with central nervous system relapse 7.4 years after bone marrow relapse of common acute lymphoblastic leukemic.
abstract: Second central nervous system (CNS) relapses represent about 7.3% of subsequent recurrences of childhood acute lymphoblastic leukemia (ALL). In most children these subsequent CNS relapses occur during the first 18 months after diagnosis of the first relapse (mean 1.42 +/- 0.73 years). We present a patient who suffered a second ALL relapse in the CNS more than seven years after diagnosis of his first relapse. The leukemic clone was completely stable over more than ten years as shown by minimal residual disease techniques. Possible reasons for the recurrence of the leukemic clone after this very long period of dormancy (e.g. role of the disease site, immune system dysfunction) are discussed.
authors.affiliation: Charité Medical Centre, Campus Virchow-Klinikum, Department of Pediatric Oncology and Hematology, Berlin, Germany. cornelia.eckert@charite.de
authors.forename: Cornelia
authors.initials: C
authors.lastname: Eckert
authors.forename: Hagen Graf
authors.initials: HG
authors.lastname: Einsiedel
authors.forename: Reinhard
authors.initials: R
authors.lastname: Hartmann
authors.forename: Arend
authors.initials: A
authors.lastname: von Stackelberg
authors.forename: Sigrid
authors.initials: S
authors.lastname: Völpel
authors.forename: Andreas
authors.initials: A
authors.lastname: Guggemos
authors.forename: Nikola
authors.initials: N
authors.lastname: Hanzsch
authors.forename: Lars
authors.initials: L
authors.lastname: Kawan
authors.forename: Karl
authors.initials: K
authors.lastname: Seeger
authors.forename: Günter
authors.initials: G
authors.lastname: Henze
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019046:Bone Marrow Neoplasms / Q000235:genetics / Q000473:pathology*; D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000473:pathology*; D002648:Child; D016371:Cranial Irradiation; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology*; D055502:Secondary Prevention; D013997:Time Factors