Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis.
The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms in the susceptibility to psoriatic arthritis. MnSOD gene polymorphisms were determined by polymerase chain reaction/restriction fragment length polymorphisms method in fifty-two patients with psoriatic arthritis and 90 healthy controls.The genotype frequency of MnSOD 1183C/T was significantly higher in patients with psoriatic arthritis than in controls. In contrast, the frequency of MnSOD 1183T/T was significantly decreased in patients with psoriatic arthritis. The phenotype frequency of MnSOD 1183C was significantly increased in patients with psoriatics arthritis in comparison to healthy controls.Therefore, MnSOD 1183C polymorphisms may be a precipitating factor for the development of psoriatic arthritis.
Yen
Jeng-Hsien
JH
Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. jehsye@kmu.edu.tw
Tsai
Wen-Chun
WC
Lin
Chia-Hui
CH
Ou
Tsan-Teng
TT
Hu
Chaur-Jong
CJ
Liu
Hong-Wen
HW
D015535:Arthritis, Psoriatic / Q000201:enzymology* / Q000235:genetics; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*
D013482:Superoxide Dismutase