title: Palmar fasciitis and arthritis syndrome associated with metastatic ovarian carcinoma: a report of four cases.
abstract: Palmar fasciitis and polyarthritis syndrome (PFPAS) is an uncommon paraneoplastic syndrome associated with several malignant neoplasms. We identified 4 patients with PFPAS and ovarian carcinoma. Palmar fasciitis, at times severe, and inflammatory polyarthritis dominated the clinical presentation in all 4 patients. In 3 of our 4 patients the presentation of palmar fasciitis and inflammatory polyarthritis preceded the diagnosis of ovarian carcinoma. Magnetic resonance scanning and biopsy examination of palmar nodules in one patient revealed findings of inflammation and fibrosis. A literature review found 10 other cases of PFPAS associated with ovarian carcinoma. Improvement in palmar fasciitis and inflammatory arthritis often occurs after successful treatment of the ovarian carcinoma. Digital contractures, however, can persist. We recommend a gynecologic examination in any woman presenting with the sudden onset of unexplained hand pain, palmar inflammatory fasciitis, palmar fibromatosis, and digital contractures.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
authors.forename: Edgar A
authors.initials: EA
authors.lastname: Martorell
authors.forename: Peter M
authors.initials: PM
authors.lastname: Murray
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Peterson
authors.forename: David M
authors.initials: DM
authors.lastname: Menke
authors.forename: Kenneth T
authors.initials: KT
authors.lastname: Calamia
mesh_terms: D000368:Aged; D001168:Arthritis / Q000209:etiology*; D003286:Contracture / Q000209:etiology*; D018292:Cystadenoma, Papillary / Q000473:pathology* / Q000628:therapy; D005208:Fasciitis / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006225:Hand; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors