title: The effect of fusafungine on post-operative pain and wound healing after pediatric tonsillectomy.
abstract: OBJECTIVE
  To investigate the effect of fusafungine spray on pain and healing process after pediatric tonsillectomy.
  
  
  METHODS
  Sixty children with ages between 4 and 14 years underwent tonsillectomy or adenotonsillectomy. The patients were randomly divided into three groups and each group consisted of 20 patients. Group 1 was treated with antibiotic (amoxicillin-clavulanic acid) plus analgesic (acetaminophen), group 2 was treated with fusafungine plus analgesic (acetaminophen) and group 3 was treated with only fusafungine. The average ages were 7.8 + 3.4, 6.6 + 2.9, and 8.2 + 3.7 for groups 1, 2, and 3, respectively. Clinical evaluations were made after the operation on the 1st (T1), 3rd (T3), 7th (T7), 10th (T10), and 14th days (T14).
  
  
  RESULTS
  There was no significant difference in post-operative pain between study groups on the post-operative 1st, 3rd, and 7th days (P > 0.05), a statistically significant difference was present between groups 1 and 3, and groups 1 and 2 on the post-operative 10th and 14th day (P = 0.018 and 0.037, respectively). Pain was less in groups 2 and 3 than in group 1 on the 10th and 14th day. Also there was a significant difference in healing time of the tonsillary beds between groups 1 and 2, and groups 1 and 3 on the 10th and 14th post-operative day (P = 0.031 and 0.001, respectively). Healing was better in groups 2 and 3 than in group 1 on the 10th and 14th day.
  
  
  CONCLUSIONS
  Fusafungine administration after tonsillectomy was found to be beneficial on post-operative pain and wound healing of tonsillary beds in pediatric population.
authors.affiliation: Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey. yakbas@superonline.com
authors.forename: Yucel
authors.initials: Y
authors.lastname: Akbas
authors.forename: Yavuz Selim
authors.initials: YS
authors.lastname: Pata
authors.forename: Murat
authors.initials: M
authors.lastname: Unal
authors.forename: Kemal
authors.initials: K
authors.lastname: Gorur
authors.forename: Deniz
authors.initials: D
authors.lastname: Micozkadioglu
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000293:Adolescent; D000336:Aerosols / Q000494:pharmacology / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D047630:Depsipeptides; D004359:Drug Therapy, Combination; D005260:Female; D005670:Fusarium; D006801:Humans; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D014068:Tonsillectomy / Q000009:adverse effects*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000336:Aerosols; D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D000082:Acetaminophen; C014001:fusafungin; D019980:Amoxicillin-Potassium Clavulanate Combination