title: Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study.
abstract: OBJECTIVE
  The REVEAL study is a randomized, controlled study of the psychological and behavioral impact of APOE disclosure in a risk assessment protocol provided to first degree relatives of patients with Alzheimer's disease. The protocol presents risk information as cumulative incidence curves. This article describes how these curves were estimated.
  
  
  METHODS
  Curves were calculated using Bayes' rule to compute the posterior survival curves incorporating APOE information.
  
  
  RESULTS
  A combination of survival data from the MIRAGE study and gender- and age-specific APOE odds ratios were used to create risk curves for males and females within each of the 6 APOE genotypes.
  
  
  CONCLUSIONS
  Utilizing comparative genotype relative risk information and survival data from family studies, estimates of gender-, age-, and genotype-specific risk can be generated for use in a risk assessment research study that features genotype disclosure.
authors.affiliation: Departments of Biostatistics and Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA.
authors.forename: L Adrienne
authors.initials: LA
authors.lastname: Cupples
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Farrer
authors.forename: A Dessa
authors.initials: AD
authors.lastname: Sadovnick
authors.forename: Norman
authors.initials: N
authors.lastname: Relkin
authors.forename: Peter
authors.initials: P
authors.lastname: Whitehouse
authors.forename: Robert C
authors.initials: RC
authors.lastname: Green
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D005192:Family Health; D005817:Genetic Counseling; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012306:Risk
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E