Imaging correlates of molecular signatures in oligodendrogliomas.
Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T(1) images and mixed intensity signal on T(1) and T(2). Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.
Megyesi
Joseph F
JF
Department of Clinical Neurological Sciences, University of Western Ontario and London Regional Cancer Centre, London, Ontario, Canada.
Kachur
Edward
E
Lee
Donald H
DH
Zlatescu
Magdalena C
MC
Betensky
Rebecca A
RA
Forsyth
Peter A
PA
Okada
Yoshifumi
Y
Sasaki
Hikaru
H
Mizoguchi
Masahiro
M
Louis
David N
DN
Cairncross
J Gregory
JG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D015398:Signal Transduction