Prevalence of drug-induced electrocardiographic pattern of the Brugada syndrome in a healthy population.
To determine the prevalence of drug-induced Brugada's syndrome (BrS) electrocardiograms (ECGs) in a healthy population, a sodium channel blockade challenge was performed in previously identified subjects with BrS-compatible (BrC) ECGs. These subjects were detected in 1,000 normal patients in whom first ECGs were systematically recorded. Because of the intermittent nature of electrocardiographic modifications in BrS, second ECGs were also recorded in a representative sample of the population presenting with first ECGs with normal results. The prevalence of typical drug-induced BrS ECGs was 5 of the 1,000 patients. This value was fivefold greater than the reported prevalence of spontaneous BrS ECGs in the healthy population.
Hermida
Jean-Sylvain
JS
Département de Cardiologie, Amiens, France. hermida.jean-sylvain@chu-amiens.fr
Jandaud
Serge
S
Lemoine
Jean-Luc
JL
Rodriguez-Lafrasse
Claire
C
Delonca
Jean
J
Bertrand
Cathy
C
Jarry
Geneviève
G
Rochette
Jacques
J
Rey
Jean-Luc
JL
D000328:Adult; D000404:Ajmaline / Q000494:pharmacology; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D002037:Bundle-Branch Block / Q000453:epidemiology* / Q000235:genetics; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D062554:NAV1.5 Voltage-Gated Sodium Channel; D018807:Polymorphism, Single-Stranded Conformational; D011446:Prospective Studies; D015222:Sodium Channels / Q000187:drug effects / Q000235:genetics; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000453:epidemiology* / Q000235:genetics
D000889:Anti-Arrhythmia Agents; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels; D000404:Ajmaline