[No improvement of lipodystrophy syndrome in an HIV-infected patient].
Lipodystrophy in patients with HIV-infection has been studied intensively to understand its epidemiology and pathophysiology. Recently its development was attributed to a dysregulation of TNF-alpha synthesis' homeostasis by HAART. A few years ago it was found that pentoxifylline decreases TNF-alpha production. We describe one HIV-infected patient, with lipodystrophy syndrome, treated with pentoxifylline without any improvement of lipodystrophic symptoms.
Lanzafame
Massimiliano
M
Divisione Clinicizzata di Malattie Infettive, Ospedale Civile Maggiore Borgo Trento, Verona. masino69@hotmail.com
Faggian
Federica
F
Lattuada
Emanuela
E
Antolini
Dario
D
Concia
Ercole
E
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015658:HIV Infections / Q000188:drug therapy*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008297:Male; D010431:Pentoxifylline / Q000627:therapeutic use*; D017211:Treatment Failure; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects* / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline