Effect of rescue or adjunctive percutaneous coronary intervention of the culprit artery after fibrinolytic administration on epicardial flow in nonculprit arteries.
We hypothesized that blood flow in noninfarct arteries would improve after percutaneous coronary intervention of the culprit artery in the setting of ST-elevation myocardial infarction (STEMI). The corrected Thrombolysis In Myocardial Infarction (TIMI) frame count was measured in 94 patients (102 arteries) enrolled in the INTEGRITI, ENTIRE, and FASTER trials of reduced dose fibrinolytic and glycoprotein IIb/IIIa inhibition. The corrected TIMI frame count in nonculprit arteries improved by 3.4 +/- 13.4 frames after percutaneous coronary intervention but remained significantly slower than flow in normal arteries.
Gardner
Graham S
GS
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Frisch
Daniel R
DR
Murphy
Sabina A
SA
Kirtane
Ajay J
AJ
Giugliano
Robert P
RP
Antman
Elliott M
EM
Braunwald
Eugene
E
Gibson
C Michael
CM
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000502:physiology; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D012039:Regional Blood Flow; D000077785:Tenecteplase; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase