Chronological changes of incidence and prognosis of children with asymptomatic congenital cytomegalovirus infection in Sapporo, Japan.
BACKGROUND
Chronological changes of the incidence of congenital cytomegalovirus (CMV) infection and the longitudinal prognosis in children with asymptomatic congenital infection were investigated.


METHODS
Congenital CMV infection, as demonstrated by isolation of the virus within the first week of life, was diagnosed in infants born in Sapporo, Japan, during the 26-year period between 1977 and 2002.


RESULTS
Congenital infection was diagnosed in 37 (0.31%) of 11,938 infants. Thirty-two infants were (86.5%) asymptomatic and 5 (13.5%) were symptomatic at birth.


CONCLUSIONS
Although a decrease in the total incidence of congenital CMV infection has been seen in recent years, screening of congenital infection at birth seems to be necessary to detect late-onset neurodevelopmental sequelae.
Numazaki
Kei
K
Department of Pediatrics, Sapporo Medical University School of Medicine Sapporo, 060-8543, Japan. numazaki@sapmed.ac.jp
Fujikawa
Tomoko
T
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D002657:Child Development; D002675:Child, Preschool; D016207:Cytokines / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital* / Q000453:epidemiology*; D016057:Evoked Potentials, Auditory, Brain Stem; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007361:Intelligence Tests; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D011379:Prognosis; D014556:Urine / Q000821:virology
D016207:Cytokines