A method to quantify the uptake rate of 2-[18F]fluoro-2-deoxy-D-glucose in tissues.
A two-compartment model is used to derive the tissue time-activity curve of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG). At the later phase of the 18F-FDG activity in the tissue, the model leads to a method which allows the assessment of the 18F-FDG uptake rate constant. The proposed method is both compared with the standard uptake value (SUV) method and with Patlak's graphical analysis.
Laffon
Eric
E
Service de Médecine Nucléaire, Hôpital du Haut_Lévêque, Centre Hospitalo_Universitaire de Bordeaux, Bordeaux, France. elaffon@u_bordeaux2.fr
Allard
Michèle
M
Marthan
Roger
R
Ducassou
Dominique
D
D000465:Algorithms; D000818:Animals; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D011865:Radioisotope Dilution Technique; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18