title: Evaluation of a novel poly(epsilon-caprolactone)-organosiloxane hybrid material for the potential application as a bioactive and degradable bone substitute.
abstract: A novel poly(epsilon-caprolactone)-organosiloxane hybrid material containing calcium salt (Si-O-PCL) was prepared and evaluated as a bioactive and degradable bone substitute material. The Si-O-PCL hybrid was synthesized by the end-capping of 3-isocyanatopropyl triethoxysilane with alpha,omega-hydroxyl PCL following sol-gel reaction with calcium nitrate tetrahydrate. Its tensile mechanical properties were evaluated, and additional specimens were exposed to simulated body fluid (SBF) for the time range from 3 h to 7 days. The SBF exposure led to the deposition of a layer of apatite crystals on the surface of the Si-O-PCL hybrid within 9 h of soaking. The tensile strength was around 18 MPa, Young's modulus was around 200 MPa, and the strain at break was around 290%. This material is likely to have a potential application as a bioactive and degradable bone substitute because of its apatite forming ability, biodegradability, and mechanical properties comparable to those of human cancellous bone.
authors.affiliation: Department of Dental Materials Science and Dental Research Institute, College of Dentistry, Seoul National University, Seoul 110-749, Korea. rhee1213@snu.ac.kr
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Rhee
authors.forename: Yong-Keun
authors.initials: YK
authors.lastname: Lee
authors.forename: Bum-Soon
authors.initials: BS
authors.lastname: Lim
authors.forename: Jeong Joon
authors.initials: JJ
authors.lastname: Yoo
authors.forename: Hee Joong
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D015394:Molecular Structure; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D012833:Siloxanes / Q000138:chemical synthesis / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; D012833:Siloxanes; C016240:polycaprolactone; D002118:Calcium