Branches on the alpha-C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding.
Zhang
Yixin
Y
Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, 06120, Halle/Saale, Germany.
Baumgrass
Ria
R
Raumgrass
Ria
R
Schutkowski
Mike
M
Fischer
Gunter
G
D019703:Calcineurin / Q000378:metabolism; D065095:Calcineurin Inhibitors; D021983:Cyclophilins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016572:Cyclosporine / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding
D065095:Calcineurin Inhibitors; D016572:Cyclosporine; D019703:Calcineurin; D021983:Cyclophilins