title: Treatment plan optimization incorporating respiratory motion.
abstract: Similar to conventional conformal radiotherapy, during lung tomotherapy, a motion margin has to be set for respiratory motion. Consequently, large volume of normal tissue is irradiated by intensive radiation. To solve this problem, we have developed a new motion mitigation method by incorporating target motion into treatment optimization. In this method, the delivery-breathing correlation is determined prior to treatment plan optimization. Beamlets are calculated by using the CT images at the corresponding breathing phases from a dynamic (four-dimensional) image sequence. With the displacement vector fields at different breathing phases, a set of deformed beamlets is obtained by mapping the dose to the primary phase. Optimization incorporating motion is then performed by using the deformed beamlets obtained by dose mapping. During treatment delivery, the same breathing-delivery correlation can be reproduced by instructing the patient to breathe following a visually displayed guiding cycle. This method was tested using a computer-simulated deformable phantom and a real lung case. Results show that treatment optimization incorporating motion achieved similar high dose conformality on a mobile target compared with static delivery. The residual motion effects due to imperfect breathing tracking were also analyzed.
authors.affiliation: Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53706, USA. tiezhizhang@wisc.edu
authors.forename: Tiezhi
authors.initials: T
authors.lastname: Zhang
authors.forename: Robert
authors.initials: R
authors.lastname: Jeraj
authors.forename: Harry
authors.initials: H
authors.lastname: Keller
authors.forename: Weiguo
authors.initials: W
authors.lastname: Lu
authors.forename: Gustavo H
authors.initials: GH
authors.lastname: Olivera
authors.forename: Todd R
authors.initials: TR
authors.lastname: McNutt
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Mackie
authors.forename: Bhudatt
authors.initials: B
authors.lastname: Paliwal
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology / Q000532:radiotherapy; D008954:Models, Biological; D009068:Movement; D019047:Phantoms, Imaging; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D020266:Radiotherapy, Conformal / Q000379:methods* / Q000706:statistics & numerical data; D015656:Respiratory Mechanics