title: Effects of a new injectable short-term release deslorelin in foal-heat mares.
abstract: Mares treated with subcutaneous deslorelin implants on the first postpartum estrus early in the breeding season had significant reductions in the number of large follicles at early pregnancy examinations and delayed return to estrus (in mares that failed to become pregnant); these adverse effects were attributed to a prolonged release of the drug from the implant. In 2003, an injectable short-term release (<24 h) deslorelin product became available. The objective of this study was to determine if this product would hasten ovulation in early foaling first postpartum estrus mares without reducing the number of large follicles at early pregnancy examination (14-15 days postovulation). Beginning 5-6 days postpartum, first postpartum estrus (foal-heat) mares were teased daily and examined thrice weekly (Tuesday, Thursday and Saturday) by transrectal ultrasonography. Mares in estrus with a follicle > or = 34 mm diameter on Tuesdays or Thursdays were alternately assigned to: Treatment 1, n = 17; 1.5 mg injectable short-term release deslorelin, or Treatment 2, n = 16; Control (no treatment). The schedule allowed accurate determination of the number of mares ovulating within 2 days of treatment (i.e., ovulations detected on Thursday or Saturday). Mares were mated on the day of treatment and at 2-day intervals until either ovulation was confirmed or until behavioral estrus ceased. Transrectal ultrasonography was done 14-15 days after ovulation to assess ovarian follicles and pregnancy status. Fewer covers were required and more mares ovulated within 2 days of treatment in deslorelin-treated versus Control mares (P < 0.01). Pregnancy rates were normal (69%) in deslorelin-treated mares. The number of large follicles 14-15 days after ovulation did not differ between deslorelin-treated and Control mares (P > 0.10), suggesting follicular suppression did not occur with this formulation of deslorelin.
authors.affiliation: Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4475, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Stich
authors.forename: K M
authors.initials: KM
authors.lastname: Wendt
authors.forename: T L
authors.initials: TL
authors.lastname: Blanchard
authors.forename: S P
authors.initials: SP
authors.lastname: Brinsko
mesh_terms: D000818:Animals; D001947:Breeding; D004343:Drug Implants; D004971:Estrus / Q000187:drug effects; D005260:Female; D006736:Horses / Q000502:physiology*; D007267:Injections; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000187:drug effects; D010062:Ovulation Induction / Q000662:veterinary; D049590:Postpartum Period; D011247:Pregnancy; D017329:Triptorelin Pamoate / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D014463:Ultrasonography / Q000662:veterinary
chemical_list: D004343:Drug Implants; D017329:Triptorelin Pamoate; C066438:deslorelin