[Hematopoietic steam cell transplantation in the management of systemic lupus erythematosus resistant to treatment].
Recently stem cell transplantation has been suggested like novel treatment in some severe auto-immune diseases, specifically in severe and refractory to conventional treatment in systemic lupus erythematosus patients. Autologus hematopoietic steam cell transplantation has been used in systemic lupus erythematosus, because it does not represent risk of development in graft versus host disease, which is the most common and severe complication in alogenic transplant. This type of transplant is poorly used because of the difficulty to get donors and laboratory background. Patients under this type of treatment received high dosage of chemotherapy, followed by alogenic hematopoietic steam cell transplantation with or without T cell depletion. Most of cases have successes in treatment and some patients get clinical and serological remission even for 34 months. However, a longer following is necessary to obtain concluding results. This paper reviews those treatments in clinical cases reported in the literature.
Rojas Ramos
Enrique
E
Departamento de inmunología clínica, alergia y reumatología, Hospital 1 de Octubre, ISSSTE, México, DF. drenriquerojas@correo.unam.mx
Martínez Jiménez
Norma E
NE
Reyes Salina
Alfredo
A
D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000628:therapy*