title: A comparative study of barrier membranes as graft protectors in the treatment of localized bone defects. An experimental study in a canine model.
abstract: Guided bone regeneration is a predictable and well-documented surgical approach for the treatment of deficient alveolar ridges prior to endosseous implant placement. The purpose of this study was to compare a new resorbable membrane (GORE RESOLUT ADAPT Regenerative Membrane, i.e. 67% glycolide (PGA) : 33% trimethyline carbonate (TMC)) with Bio-Gide, a resorbable collagen membrane. Five canines were used in the study. Three saddle-type osseous defects were created bilaterally in edentulous areas of the mandible. The defects were filled with assayed, canine demineralized freeze-dried bone (DFDB) in a thermoplastic gelatin matrix. Using a randomized block design, four sites were covered with PGA : TMC membranes of four different porosities, one site was covered with a collagen membrane and one site consisted of DFDB alone (control). At 3 months, the animals were euthanized and the mandibles were removed en bloc for laboratory processing. A total of 30 sites were reviewed microradiographically and underwent histomorphometric analysis for bone regeneration, soft tissue presence and remaining graft material. All sites exhibited uneventful healing. A significantly higher percentage of bone regeneration was seen in the sites protected by the PGA : TMC membrane. A higher component of soft tissue was visible beneath the collagen membrane as compared with the PGA : TMC membrane. The control sites exhibited noticeable deformation of the regenerated bone secondary to collapse of the overlying periosteum. The authors conclude that the PGA : TMC membrane protected the DFDB-filled defect and allowed a greater amount of bone regeneration than the defect protected by the collagen membrane or the control.
authors.affiliation: Center for Implant Dentistry, Department of Oral & Maxillofacial Surgery & Diagnostic Sciences, College of Dentistry, University of Florida, FL, USA. fstavrop@dental.ufl.edu
authors.forename: Franci
authors.initials: F
authors.lastname: Stavropoulos
authors.forename: Christer
authors.initials: C
authors.lastname: Dahlin
authors.forename: James D
authors.initials: JD
authors.lastname: Ruskin
authors.forename: Carina
authors.initials: C
authors.lastname: Johansson
mesh_terms: D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D001861:Bone Regeneration; D016025:Bone Transplantation; D003094:Collagen; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D019344:Lactic Acid; D008297:Male; D008567:Membranes, Artificial; D008852:Microradiography; D023421:Models, Animal; D011098:Polyglactin 910; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers
chemical_list: C106416:Bio-Gide; D008567:Membranes, Artificial; D011108:Polymers; C094810:Resolut; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011098:Polyglactin 910; C046409:polyglyconate; D003094:Collagen