title: Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation.
abstract: Both acute and chronic inflammatory states are associated with decreased levels of high-density lipoprotein (HDL) cholesterol, yet the underlying mechanism is poorly understood. Endothelial lipase (EL), a recently described member of the triglyceride lipase family, has been shown to be a key enzyme in HDL metabolism. Expression of EL by endothelial cells is upregulated by proinflammatory cytokines and is associated with increased EL-specific triglyceride and phospholipase activity in vitro. Thus, EL may play an important role in lipid metabolism and energy homeostasis in states of acute and chronic inflammation.
authors.affiliation: School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Uli C
authors.initials: UC
authors.lastname: Broedl
authors.forename: Weijun
authors.initials: W
authors.lastname: Jin
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rader
mesh_terms: D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008049:Lipase / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*
chemical_list: D008074:Lipoproteins; C410382:LIPG protein, human; D008049:Lipase