Isotopomeric polymorphism.
The complex formed between 4-methylpyridine and pentachlorophenol (4MPPCP) crystallizes in a triclinic space group. If the same complex is synthesized from deuterated pentachlorophenol (4MPPCP-d1), it crystallizes in an entirely different monoclinic polymorph. Solid-state NMR of samples synthesized with a full range of deuteration levels, crystallized from solution or the melt, and in the presence or absence of seeds confirms that the isotopomers indeed have different thermodynamically stable crystal structures. The phenomenon is apparently due to very different hydrogen bond strengths between the two polymorphs.
Zhou
Jun
J
Department of Chemistry, University of Nebraska at Lincoln, Lincoln, Nebraska 68588, USA.
Kye
Young-Sik
YS
Harbison
Gerard S
GS
D003903:Deuterium; D006860:Hydrogen Bonding; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010416:Pentachlorophenol / Q000031:analogs & derivatives* / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D013816:Thermodynamics
D011725:Pyridines; D003903:Deuterium; D010416:Pentachlorophenol