Insulin resistance and insulin secretion in chronic hepatitis C virus infection.
OBJECTIVE
Diabetes mellitus (DM) is frequently observed in patients with chronic hepatitis caused by hepatitis C virus infection (CHC). The present study was designed to determine the pathogenic factors responsible for glucose intolerance in CHC patients.


METHODS
A total of 131 patients with CHC were enrolled in this study. Insulin resistance and beta-cell function were determined after 75 g oral glucose tolerance tests.


RESULTS
Glucose intolerance was detected in 27.5% (36/131) of CHC patients; 10 had DM and 26 impaired glucose tolerance. HOMA-R [insulin 0xglucose 0/22.5] was greater in patients with both impaired glucose tolerance and DM than in those with normal glucose tolerance (P<0.01). Matsuda index [10(4)/ (square root) (mean insulinxmean glucosexglucose 0xinsulin 0)] was lower in diabetic patients than in those with normal glucose tolerance (P<0.05). The insulinogenic index [Deltainsulin 30-0/Deltaglucose 30-0] and DeltaC-peptide 30 [DeltaC-peptide 30-0/Deltaglucose 30-0] were significantly lower even in patients with impaired glucose tolerance than in patients with normal glucose tolerance (P<0.01).


CONCLUSIONS
Both insulin resistance and beta-cell dysfunction contribute to glucose intolerance in CHC patients.
Narita
Ryoichi
R
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Abe
Shintaro
S
Kihara
Yasuyuki
Y
Akiyama
Toshiharu
T
Tabaru
Akinari
A
Otsuki
Makoto
M
D000328:Adult; D002096:C-Peptide / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000378:metabolism* / Q000473:pathology; D005951:Glucose Tolerance Test; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D015995:Prevalence
D002096:C-Peptide; D007328:Insulin