title: Two complementary approaches toward 2-alkoxy carboxylic acid synthesis from 1,3-dioxolan-4-ones.
abstract: Two complementary approaches to prepare 2-alkoxy carboxylic acids have been developed. Reductive ring opening of various 1,3-dioxolan-4-ones using TiCl(4)/Et(3)SiH or (t)BuMgCl affords the desired 2-alkoxy carboxylic acid in moderate to excellent chemical yield without loss of optical purity.
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
authors.forename: Leonard L
authors.initials: LL
authors.lastname: Winneroski
authors.forename: Yanping
authors.initials: Y
authors.lastname: Xu