Effect of mercuric chloride on circulating hormones in adult albino rats.
The effect of mercuric chloride at two different doses, 0.5 mg/kg body weight (low dose), 1 mg/kg body weight (high dose), for 30 days, was seen on the circulating hormones in the mature male albino rats. Testosterone level was markedly decreased in the low dose (P < 0.01) and high dose (P < 0.001) treated animals. The level of luteinizing hormone (LH) was also reduced in the low dose (P < 0.01) as well as in the high dose (P < 0.001) treated animals. However, follicle stimulating hormone (FSH) and prolactin (PRL) levels were found to be decreased only in the high dose (P < 0. 05) treated animals and no change was observed in the low dose treated animals. The changes in the hormone levels caused by the mercuric chloride treatment suggest the dysfunction of pituitary-testicular axis.
Ramalingam
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Department of Zoology, Bharathidasan Government College for Women, Pondicherry-605 003, India. ramalingamv18@yahoo.com
Vimaladevi
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Rajeswary
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Suryavathi
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D000818:Animals; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D008627:Mercuric Chloride; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone