Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.
Tschöp
M
M
Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA. tschoemh@ucmail.uc.edu
Castañeda
T R
TR
Joost
H G
HG
Thöne-Reineke
C
C
Ortmann
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Klaus
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Hagan
M M
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Chandler
P C
PC
Oswald
K D
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Benoit
S C
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Seeley
R J
RJ
Kinzig
K P
KP
Moran
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Beck-sickinger
A G
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Koglin
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Rodgers
R J
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Blundell
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Ishii
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Beattie
A H
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Holch
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Allison
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Raun
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Madsen
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Wulff
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Stidsen
C E
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Birringer
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Kreuzer
O J
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Schindler
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Arndt
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Rudolf
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Mark
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Deng
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Whitcomb
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Taylor
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Dong
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Datta
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Culler
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Craney
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Flora
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Smiley
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Heiman
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Withcomb
D C
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D000818:Animals; D017849:Animals, Inbred Strains; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D001067:Appetite Depressants / Q000494:pharmacology* / Q000627:therapeutic use; D001069:Appetite Regulation / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004777:Environment; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D015201:Meta-Analysis as Topic; D051379:Mice; D009765:Obesity / Q000188:drug therapy; D010446:Peptide Fragments; D019894:Peptide YY / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D015203:Reproducibility of Results; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology
D001067:Appetite Depressants; D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36)