title: Development of biodegradable aluminium carboxymethylcellulose matrices for mosquito larvicides.
abstract: The use of ecofriendly biodegradable controlled-release formulations of mosquito larvicides could reduce the frequency of application and losses due to degradation of the insecticide compared with conventional formulations. Among the 20 matrices developed by entrapping the organophosphorus mosquito larvicide, fenthion, in carboxymethylcellulose ionotropically cross-linked with aluminium ions which were studied for release profiles, two matrices, CRF3b and CRF5b, were found to be stable for 16 and 14 weeks under simulated field conditions. The average concentration of fenthion released per week ranged from 0.06 to 3.5 mg litre(-1) for CRF3b and 0.09 to 2.72 mg litre(-1) for CRF5b. Of these two formulations, CRF3b was the more stable, maintaining the concentration of the active ingredient at the level required to effect mosquito control. The cumulative release of fenthion per pellet was 80% from CRF3b and 72% from CRF5b. Based on the study with fenthion, two similar matrices for triflumuron, a benzoylphenylurea insect growth regulator, STAR3b and STAR5b were developed. These matrices were stable up to 16 weeks with the average concentration of triflumuron released per week ranging from 0.05 to 3.44 mg litre(-1) for STAR3b and 0.07 to 2.71 mg litre(-1) for STARSb. The cumulative release of triflumuron per pellet was 75% from STAR3b and 76% from STAR5b. From the results of this study under simulated conditions, it is estimated that the application of four pellets of either fenthion or triflumuron per square metre of the breeding surface may play a useful role in controlling Culex quinquefasciatus Say in larval habitats for about 4 months.
authors.affiliation: Vector Control Research Centre (ICMR) Pondicherry 605 006, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Mathew
authors.forename: Muthuswami
authors.initials: M
authors.lastname: Kalyanasundaram
mesh_terms: D000535:Aluminum / Q000378:metabolism*; D000818:Animals; D001673:Biodegradation, Environmental; D002266:Carboxymethylcellulose Sodium / Q000378:metabolism*; D009033:Culicidae / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity*; D007814:Larva / Q000187:drug effects*; D009032:Mosquito Control / Q000379:methods
chemical_list: D007306:Insecticides; D000535:Aluminum; D002266:Carboxymethylcellulose Sodium