title: Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.
abstract: We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and anterior and posterior putamen (p < 0.0001) of PD patients compared to controls. Using the posterior putamen as the main region of interest resulted in the greatest accuracy (sensitivity 0.79, specificity 0.92). These findings show that TRODAT imaging can accurately differentiate early PD patients from controls and has the potential to improve the diagnosis of patients with early signs of PD.
authors.affiliation: Parkinson's Disease and Movement Disorders Center, University of Pennsylvania School of Medicine, Pennsylvania Hospital, 330 South Ninth Street, Philadelphia, PA 19107, USA. chouk@uphs.upenn.edu
authors.forename: K L
authors.initials: KL
authors.lastname: Chou
authors.forename: H I
authors.initials: HI
authors.lastname: Hurtig
authors.forename: M B
authors.initials: MB
authors.lastname: Stern
authors.forename: A
authors.initials: A
authors.lastname: Colcher
authors.forename: B
authors.initials: B
authors.lastname: Ravina
authors.forename: A
authors.initials: A
authors.lastname: Newberg
authors.forename: P D
authors.initials: PD
authors.lastname: Mozley
authors.forename: A
authors.initials: A
authors.lastname: Siderowf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000592:standards*; D014326:Tropanes
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1