title: Treatment planning dosimetric parameters for 192Ir seed at short distances: effects of air channels and neighboring seeds based on Monte Carlo study.
abstract: The dose distributions around two different arrangements of a single radioactive 192Ir seed in water, (1) with air channels at the ends, and (2) surrounded by two nonactive ("dummy") seeds on both longitudinal ends, were calculated using MCNP4C Monte Carlo simulations at distances up to 1 cm. The contributions from beta particles and electrons emitted by 192Ir were included in the calculations. The effects of (a) the air channels at the seed ends and (b) the interference effect of the dummy seeds on the dose distribution were quantified and compared. It was found that the dummy seeds do not cause significant dose reduction for radial distances beyond 0.05 cm from the seed center. It is decided to report the dose rate values and the dosimetric parameters in TG43 format for a single seed with air channels for use in treatment planning computer systems. The dose rate constant (at 1 cm) of 192Ir seed, lambda, is 1.108 cGyU(-1) h(-1). The values of radial dose function, g(r), are within 1% from the TG43 recommended polynomial fit, except for distances within 0.08 cm. The anisotropy function, F(r, theta), attains large values near the seed ends and shallow angles (up to 8), as well as many values greater than 2 at the 20 degrees polar angle. Treatment planning systems involving intravascular brachytherapy do not compromise the accuracy for dosimetry of multiple seed trains by summing single seed values in water.
authors.affiliation: Beth Israel Medical Center, New York, New York 10003, USA.
authors.forename: Neil S
authors.initials: NS
authors.lastname: Patel
authors.forename: Sou-Tung
authors.initials: ST
authors.lastname: Chiu-Tsao
authors.forename: J Allen
authors.initials: JA
authors.lastname: Shih
authors.forename: Yunsil
authors.initials: Y
authors.lastname: Ho
authors.forename: Hung-Sheng
authors.initials: HS
authors.lastname: Tsao
authors.forename: Louis B
authors.initials: LB
authors.lastname: Harrison
mesh_terms: D000388:Air; D055592:Biophysical Phenomena; D001703:Biophysics; D001808:Blood Vessels / Q000528:radiation effects; D001918:Brachytherapy / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data
chemical_list: D007496:Iridium Radioisotopes