title: Relationship between cohesive energy density and hydrophobicity.
abstract: It has been recently claimed that the large cohesive energy density of water is the ultimate cause of the poor solubility of nonpolar compounds in water. In order to test the validity of this idea, we analyze the difference in solubility between light water and heavy water of several nonpolar compounds. Even though the cohesive energy density of D(2)O is larger than that of H(2)O, nonpolar compounds are slightly more soluble in D(2)O than H(2)O. In such case experimental data do not support the correctness of the large cohesive energy density as the ultimate cause of hydrophobicity. We show that D(2)O is a slightly better solvent than H(2)O for nonpolar compounds because it is slightly less costly to create a cavity in the former liquid. This is because there is slightly more void volume in heavy water than in light water.
authors.affiliation: Dipartimento di Scienze Biologiche ed Ambientali, Universita del Sannio, Via Port'Arsa, 11-82100 Benevento, Italy. graziano@unisannio.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Graziano