Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats.
Effect of methanolic extract of P. Pinnata roots (PPRM) was studied against various experimental gastric ulcer models and offensive and defensive gastric mucosal factors in rats. An initial dose-response study using 12.5-50 mg/kg P. Pinnata root extract, when given orally in two divided dose for 4 days + 5th full dose on the day of experiment 60 min before the experiment, indicated 25 mg/kg as an optimal regimen and was used for further study. PPRM showed significant protection against aspirin and 4 hr PL, but not against ethanol-induced gastric ulceration. It showed tendency to decrease acetic acid-induced ulcer after 10 days treatment. Ulcer protective effect of PPRM was due to augmentation of mucosal defensive factors like mucin secretion, life span of mucosal cells, mucosal cell glycoproteins, cell proliferation and prevention of lipid per oxidation rather than on the offensive acid-pepsin secretion.
Prabha
T
T
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.
Dora Babu
M
M
Priyambada
S
S
Agrawal
V K
VK
Goel
R K
RK
D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001241:Aspirin / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects*; D006023:Glycoproteins / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D033641:Millettia / Q000737:chemistry*; D009077:Mucins / Q000378:metabolism; D010434:Pepsin A / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000891:Anti-Infective Agents, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D005609:Free Radicals; D006023:Glycoproteins; D009077:Mucins; D010936:Plant Extracts; D000431:Ethanol; D010434:Pepsin A; D019342:Acetic Acid; D001241:Aspirin