GSTT1 gene deletion is associated with lung cancer in Mexican patients.
Glutathione S-transferase (GST) is a dimeric detoxifying isoenzyme, involved in the deactivation of carcinogens, several tobacco-derived carcinogens, and xenobiotics. It catalyzes the reduction of glutathione to its thioester; thus, deficiency in GST activity due to homozygous deletion of the GSTT1 gene (null genotype) may play a role in the induction of lung cancer by smoking. We studied the distribution of GSTT1 gene deletion in peripheral blood DNA samples from 178 healthy controls (41 nonsmokers, 63 passive smokers and 74 smokers) and 52 lung cancer patients. Comparisons between groups showed that there was an increased lung cancer risk for individuals with the GSTT1 null genotype. Cancer patients showed significant differences when compared with controls: nonsmokers, passive smokers, and smokers. Twenty-one percent of lung cancer patients carried the deletion versus 2% among nonsmokers not exposed to passive smoking, 6% among passive smokers, and 5% among smokers. Thus, there is a significant association between this genotype and the possibility to risk of developing lung cancer.
Gallegos-Arreola
M P
MP
División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Guadalajara Jalisco, México.
Gómez-Meda
B C
BC
Morgan-Villela
G
G
Arechavaleta-Granell
M R
MR
Arnaud-López
L
L
Beltrán-Jaramillo
T J
TJ
Gaxiola
R
R
Zúñiga-González
G
G
D017353:Gene Deletion; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008800:Mexico
C491107:GSTT2 protein, human; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase