title: [Usefulness of serum markers in renal cell carcinoma].
abstract: OBJECTIVE
  To select a group of useful serum markers in renal cell carcinoma (RCC) with investigational purpose in future.
  
  
  METHODS
  Periodic determination in serum of 21 RCC patients of the following markers: EGR, RPC, hemogram and leucocyte differential count (LDC), standard biochemist parameters, beta-2 microglobuline, CEA, CA 12.5, CA 50, CA 15.3, ferritin, interleukin-6, serum interleukin-2 receptor, TNF-alpha and TPSA.
  
  
  RESULTS
  Different elements within the LDC had relations with the presence of symptoms/signs, tumour size, pathological stage and disease progression. There was a significant increase of beta-2 microglobuline and sIL-2 receptor when disease progressed, as well as a similar statistical trend with RPC and alkaline phosphatases. Beta-2 microglobuline and sIL-2 receptor also decreased after treatment of the disease progression.
  
  
  CONCLUSIONS
  We will keep analysing hemogram, LDC and standard byochemics, RPC, ferritin, beta-2 microglobuline and sIL-2 receptor only with investigational purposes, obviating the determination of the rest of the tested markers.
authors.affiliation: Servicio Urología, Instituto Valenciano de Oncología, Valencia.
authors.forename: J
authors.initials: J
authors.lastname: Rubio Briones
authors.forename: I
authors.initials: I
authors.lastname: Iborra Juan
authors.forename: E
authors.initials: E
authors.lastname: Aznar
authors.forename: M A
authors.initials: MA
authors.lastname: Climent
authors.forename: J A
authors.initials: JA
authors.lastname: López-Guerrero
authors.forename: J
authors.initials: J
authors.lastname: Maíquez
authors.forename: J L
authors.initials: JL
authors.lastname: Monrós Lliso
authors.forename: J
authors.initials: J
authors.lastname: Casanova Ramón-Borja
authors.forename: R
authors.initials: R
authors.lastname: Dumont Martínez
authors.forename: J V
authors.initials: JV
authors.lastname: Ricós Torrent
authors.forename: E
authors.initials: E
authors.lastname: Solsona Narbón
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor