[Mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy].
OBJECTIVE
To observe the effects of mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy.


METHODS
A total of 102 cases of tubal ectopic pregnancy diagnosed at early stage were enrolled to receive oral mefepristone at the dose of 75 mg twice daily for 3 d and intramuscular injection with calcium leucovorin at 0.1 mg/kg 24 h after a single dose of methotrexate injection (1 mg/kg.b.w.). In the control group consisting of 86 similar cases, intramuscular injection with calcium leucovorin at 0.1 mg/kg was given 24 h after a single dose of methotrexate (1 mg/kg.b.w.).


RESULTS
Ninety-four of the 102 cases ( 92.20%) receiving oral mifepristone combined with calcium leucovorin and methotrexate were cured, a curative rate significantly higher than that in the control group, where 70 cases (81.4%) were cured (P<0.05).


CONCLUSIONS
Mefepristone combined with methotrexate is safe and effective in the treatment of tubal ectopic pregnancy, without obvious side effects.
Li
Zhuo-hua
ZH
Department of Obstetrics and Gynecology, Second People's Hospital of Shantou, Shantou 515011, China.
Quan
Song
S
D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D015735:Mifepristone / Q000008:administration & dosage*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*
D015735:Mifepristone; D008727:Methotrexate