title: Endemic, epidemic clone of Salmonella enterica serovar typhi harboring a single multidrug-resistant plasmid in Vietnam between 1995 and 2002.
abstract: Salmonella enterica serovar Typhi strains resistant to ampicillin, chloramphenicol, tetracyclines, streptomycin, and cotrimoxazole, isolated from sporadic cases and minor outbreaks in Vietnam between 1995 and 2002, were typed and compared. Plasmid fingerprinting, Vi bacteriophage typing, XbaI pulsed-field gel electrophoresis, and PstI ribotyping showed that endemic, epidemic multidrug-resistant typhoid fever was due, for at least 74.1% of the isolates, to one or two clones of serovar Typhi harboring a single resistance plasmid. PstI ribotyping was used as a basic technique to ensure that a serovar Typhi expansion was clonal.
authors.affiliation: Laboratoire d'Epidemiologie de la Résistance Bactérienne, Institut d'Hygiène et d'Epidémiologie, Paris, France.
authors.forename: Thi Anh Hong
authors.initials: TA
authors.lastname: Le
authors.forename: Monique
authors.initials: M
authors.lastname: Lejay-Collin
authors.forename: Patrick A D
authors.initials: PA
authors.lastname: Grimont
authors.forename: Thuy Long
authors.initials: TL
authors.lastname: Hoang
authors.forename: Thi Vinh
authors.initials: TV
authors.lastname: Nguyen
authors.forename: Francine
authors.initials: F
authors.lastname: Grimont
authors.forename: Maurice R
authors.initials: MR
authors.lastname: Scavizzi
mesh_terms: D003227:Conjugation, Genetic; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D010957:Plasmids; D012485:Salmonella typhi / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D013997:Time Factors; D014435:Typhoid Fever / Q000453:epidemiology; D014744:Vietnam / Q000453:epidemiology