title: Sarcoidosis after surgically induced remission of Cushing's disease.
abstract: OBJECTIVE
  To describe a rare case of sarcoidosis diagnosed after surgical resection of an adenoma in a patient with Cushing's disease.
  
  
  METHODS
  We present a case report and discuss the only other similar case identified from the published medical literature.
  
  
  RESULTS
  In a 33-year-old woman with symptoms of cortisol excess (including progressive weight gain, proximal muscle weakness, ecchymoses, and amenorrhea), laboratory studies showed serum cortisol values consistent with Cushing's syndrome. After inferior petrosal sinus sampling, the patient underwent surgical resection of an adenoma in the right aspect of the anterior pituitary gland. Maintenance corticosteroid therapy was implemented, and the signs and symptoms of Cushing's disease began to resolve. Five months postoperatively, multiple erythematous lesions developed on the patient's arms and legs. Skin biopsy specimens demonstrated noncaseating granulomas, and sarcoidosis was diagnosed. Two months later, the lesions resolved spontaneously without therapy other than continued corticosteroid replacement.
  
  
  CONCLUSIONS
  Physicians should be aware that unusual postoperative symptoms in a patient who has undergone successful treatment of Cushing's syndrome may be attributable to the emergence of another corticosteroid-responsive disease such as sarcoidosis.
authors.affiliation: Section of Endocrine Neoplasia and Hormonal Disorders, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: M
authors.initials: M
authors.lastname: Maldonado
authors.forename: P
authors.initials: P
authors.lastname: Orlander
authors.forename: S Y
authors.initials: SY
authors.lastname: Roshan
authors.forename: I E
authors.initials: IE
authors.lastname: McCutcheon
authors.forename: K R
authors.initials: KR
authors.lastname: Cleary
authors.forename: K E
authors.initials: KE
authors.lastname: Friend