title: Dose-ranging studies of the safety and immunogenicity of human papillomavirus Type 11 and Type 16 virus-like particle candidate vaccines in young healthy women.
abstract: Two candidate vaccines to prevent infection with human papillomavirus (HPV) Types 11 and 16 were studied in similar double-blind, placebo-controlled, dose-escalation trials. L1 virus-like particle (VLP) vaccines were made from recombinant L1 capsid protein of HPV11 or HPV16. Participants received 10, 20, 50, or 100 microg of HPV11 L1 VLPs, 10, 40, or 80 microg of HPV16 L1 VLPs, or placebo at Months 0, 2, and 6. Serum geometric mean antibody levels at Month 7 were 258, 644, 647, and 1112 milli-Merck units (mMU)/ml for the 10, 20, 50, and 100 microg doses of the HPV11 L1 VLP vaccine, respectively, and 479, 808, and 732 mMU/ml for the 10, 40, and 80 microg doses of the HPV16 L1 VLP vaccine, respectively. Antibody to HPV11 and 16 was still present at Month 36 in 96.8 and 93.5% of vaccinees, respectively. Both vaccines were well tolerated and were associated with only mild to moderate injection-site reactions.
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Fife
authors.forename: Cosette M
authors.initials: CM
authors.lastname: Wheeler
authors.forename: Laura A
authors.initials: LA
authors.lastname: Koutsky
authors.forename: Eliav
authors.initials: E
authors.lastname: Barr
authors.forename: Darron R
authors.initials: DR
authors.lastname: Brown
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Schiff
authors.forename: Nancy B
authors.initials: NB
authors.lastname: Kiviat
authors.forename: Kathrin U
authors.initials: KU
authors.lastname: Jansen
authors.forename: Harriet
authors.initials: H
authors.lastname: Barber
authors.forename: Judith F
authors.initials: JF
authors.lastname: Smith
authors.forename: Amha
authors.initials: A
authors.lastname: Tadesse
authors.forename: Katherine
authors.initials: K
authors.lastname: Giacoletti
authors.forename: Paula R
authors.initials: PR
authors.lastname: Smith
authors.forename: Gretchen
authors.initials: G
authors.lastname: Suhr
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Johnson
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D036022:Capsid Proteins / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004311:Double-Blind Method; D023381:Endpoint Determination; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D027383:Papillomaviridae / Q000276:immunology*; D053918:Papillomavirus Vaccines; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D036022:Capsid Proteins; D053918:Papillomavirus Vaccines; D014765:Viral Vaccines