Apoptosis in osteoarthritis.
Many studies have shown that apoptotic cell death occurs at an increased rate in osteoarthritic cartilage. Whichever type of cell death takes places in articular cartilage, it is important to prevent, because it is detrimental to articular cartilage maintenance. Thus, it is important to characterize events going on during cellular degeneration in more detail. Overall, physicians have reached a reasonable level of understanding of the extent of cell death occurring in the disease process, but they are still at an early stage in the understanding of the mechanisms underlying this process and the means of intervening in this facet of cartilage destruction.
Aigner
Thomas
T
Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstrasse 8-10, 91054 Erlangen, Germany. thomas.aigner@patho.imed.uni-erlangen.de
Kim
Hyun A
HA
Roach
Helmtrud I
HI
D017209:Apoptosis; D002358:Cartilage, Articular / Q000473:pathology; D006801:Humans; D010003:Osteoarthritis / Q000473:pathology*