Significance of primary hyperparathyroidism in the management of osteoporosis.
Primary hyperparathyroidism (HPT) has catabolic effects on cortical bone and anabolic effects on cancellous bone with overall deleterious effects on skeleton. Primary HPT is associated with increased fracture risk both at the cancellous bone-enriched spine and the cortical bone-enriched distal one third of the radius. This risk is reversed by parathyroidectomy.
Saleem
Tipu Faiz M
TF
The Reading Hospital and Medical Center, PA, USA. saleemt@readinghospital.org
Horwith
Melvin
M
Stack
Brendan C
BC
D015519:Bone Density; D001842:Bone and Bones / Q000503:physiopathology; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology* / Q000628:therapy; D010024:Osteoporosis / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000502:physiology; D016105:Parathyroidectomy; D012307:Risk Factors
D010281:Parathyroid Hormone