title: Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia.
abstract: We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL.
authors.forename: Davide
authors.initials: D
authors.lastname: Soligo
authors.forename: Marina
authors.initials: M
authors.lastname: Motta
authors.forename: Chiara
authors.initials: C
authors.lastname: Borsotti
authors.forename: Adalberto
authors.initials: A
authors.lastname: Ibatici
authors.forename: Agostino
authors.initials: A
authors.lastname: Cortelezzi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Lambertenghi Deliliers
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous