Chemokines in neoplastic progression.
Chemokines and their receptors have emerged as attractive targets regulating the migration of tumor cells in vivo, a process known as cancer metastasis. The control of metastasis is critical to the control of cancer progression. Two chemokine receptors and their ligands stand out as likely targets for therapeutics: CCR7/CCL21 for lymph node metastases, and CXCR4/CXCL12 for lung, liver, bone marrow, and brain metastases. The most widely expressed chemokine receptor among cancers is likely to be CXCR4.
Zlotnik
Albert
A
Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA. azlotnik@neurocrine.com
D018925:Chemokines / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D019707:Receptors, Chemokine / Q000378:metabolism
D018925:Chemokines; D019707:Receptors, Chemokine