title: Poly methacrylic acid-alginate semi-IPN microparticles for oral delivery of insulin: a preliminary investigation.
abstract: Microparticles of Poly methacrylic acid (P1) and novel semi-interpenetrating network composed of Poly methacrylic acid-alginate (P2) were prepared and their application in oral insulin delivery was evaluated. The microparticles were characterized by scanning electron microscopy (SEM) for morphological studies. Insulin loading onto the microparticles was performed by the diffusion filling method and insulin encapsulated microparticles were subjected to in vitro release study in buffer solution of pH 1.2 and 7.4. The release kinetics at pH 7.4 exhibited sustained release of insulin for more than 5 h in case of PMAA microparticles whereas burst release of insulin (90% of total insulin loaded) within 1 h of study was observed in the case of PMAA-alginate microparticles. At pH 1.2, around 30% of insulin loaded was released from both microparticles within 2 h of study.
authors.affiliation: Division of Biosurface Technology, Bio Medical Technology Wing, Sree Chitra Tirunal Institute of Medical Science and Technology, Trivandrum-695 012, India.
authors.forename: S
authors.initials: S
authors.lastname: Sajeesh
authors.forename: Chandra P
authors.initials: CP
authors.lastname: Sharma
mesh_terms: D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D007328:Insulin; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D020723:Glucuronic Acid