title: Effect of amaranth leaves on dimethylhydrazine-induced changes in multicomponent antioxidant system of rat liver.
abstract: Effect of prefeeding dehydrated amaranth (A. gangeticus) leaves at 10 and 20% levels on a chemical toxicant, dimethylhydrazine (DMH)-induced free radical stress in rat liver was evaluated. DMH-induced rise in hepatic malondialdehyde (MDA), was diminished by AL. AL intake resulted in a significant increase in hepatic glutathione (GSH). The feeding of AL at 10% level increased the hepatic glucose-6-phosphate dehydrogenase (G-6-PDH) activity, while that at 20% level increased the hepatic glutathione reductase (GSSGR) as well, in addition to G-6-PDH. Amaranth leaves at 10 and 20% levels of feeding diminished the hepatic superoxide dismutase and glutathione peroxidase (GSH-Px) activities. DMH influenced adversely the hepatic antioxidant enzyme activities. Simultaneous administration of DMH and feeding of AL enhanced the DMH-induced decrease in hepatic GSH-Px. DMH enhanced formation of micronuclei was reverted significantly by AL intake. Hence, it was concluded that the consumption of AL at 20% level reduced DMH-induced impaired antioxidant status in rat liver.
authors.affiliation: Biochemistry and Nutrition Discipline, Defence Food Research Laboratory, Mysore 570 011, India. dfoodlab@sancharnet.in
authors.forename: K R
authors.initials: KR
authors.lastname: Anilakumar
authors.forename: Farhath
authors.initials: F
authors.lastname: Khanum
authors.forename: K R
authors.initials: KR
authors.lastname: Sudarshanakrishna
authors.forename: K
authors.initials: K
authors.lastname: Santhanam
mesh_terms: D027721:Amaranthus / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001835:Body Weight; D001853:Bone Marrow / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D004127:Dimethylhydrazines / Q000494:pharmacology*; D005609:Free Radicals; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000494:pharmacology; D048629:Micronuclei, Chromosome-Defective / Q000378:metabolism; D009929:Organ Size; D018384:Oxidative Stress; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004127:Dimethylhydrazines; D005609:Free Radicals; D010936:Plant Extracts; D008315:Malondialdehyde; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione