Hair analysis differentiates chronic from acute carbamazepine intoxication.
This is a report of a 12-year-old epileptic child undergoing chronic treatment with carbamazepine who was found comatose. He was considered to have acute severe drug toxicity. Measurement of carbamazepine concentration in the patient's hair segments together with the carbamazepine blood levels were both important in determining the chronic nature of the patient's intoxication.
Mantzouranis
Evangelia C
EC
Department of Pediatrics, University Hospital of Heraklion, Heraklion, Crete, Greece.
Bertsias
George K
GK
Pallis
Eleftherios G
EG
Tsatsakis
Aristidis M
AM
D000208:Acute Disease; D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D002220:Carbamazepine / Q000097:blood / Q000506:poisoning*; D002648:Child; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans
D000927:Anticonvulsants; D002220:Carbamazepine