Long-term effects of immunization with recombinant lipoprotein outer surface protein a on serologic test for lyme disease.
Immunization with recombinant lipoprotein outer surface protein A vaccine is known to interfere with some serologic tests for Lyme disease. We tested sera from 152 vaccine recipients by using in-house and commercial Western blot assays and found that vaccination caused interference in up to 25% of recipients and can persist for over 6 years.
Fawcett
Paul T
PT
Immunology Laboratory, Department of Research, A. I. duPont Hospital for Children, Wilmington, Delaware 19803, USA. pfawcett@nemours.org
Rose
Carlos D
CD
Maduskuie
Victoria
V
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001428:Bacterial Vaccines; D015153:Blotting, Western; D025065:Borrelia burgdorferi / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008074:Lipoproteins / Q000276:immunology*; D008193:Lyme Disease / Q000175:diagnosis*; D011994:Recombinant Proteins / Q000276:immunology; D012698:Serologic Tests / Q000592:standards*; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects*
D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D008074:Lipoproteins; C072045:OspA protein; D011994:Recombinant Proteins