Association between lenticulostriate vasculopathy (LSV) and neonatal intraventricular hemorrhage (IVH).
OBJECTIVE
To determine whether there is an unconfounded association between neonatal intraventricular hemorrhage (IVH) and lenticulostriate vasculopathy (LSV (also known as thalamostriate or mineralizing vasculopathy)).


METHODS
During the conduct of the Magnesium and Neurologic Endpoints Trial (MagNET), a randomized controlled trial involving maternal, hence fetal, exposure to antenatal magnesium sulfate in the context of preterm labor, head ultrasounds were obtained for each of the surviving neonates. Because of our previous experience in the diagnosis of LSV, when ascertaining the presence of IVH, as called for by the research protocol of our study, the presence or absence of LSV was also determined.


RESULTS
We found LSV to be relatively prevalent (10% (14 of 140) among surviving babies). More importantly, it was significantly associated with the occurrence of neonatal IVH, even when controlled for possible confounding (adjusted OR 9.8, 95% confidence interval 1.3 to 73.1; p=0.03).


CONCLUSIONS
Given the known relationships between IVH and neonatal morbidity and mortality, the finding of a statistically significant association between neonatal IVH and LSV may suggest more substantial implications for the latter than previously believed.
Mittendorf
Robert
R
Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL 60153, USA.
Covert
Robert
R
Pryde
Peter G
PG
Lee
Kwang-Sun
KS
Ben-Ami
Tamar
T
Yousefzadeh
David
D
D020144:Basal Ganglia Cerebrovascular Disease / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn