title: Regulation of Bcl-2 proteins during anoikis and amorphosis.
abstract: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Numerous signaling pathways converge to affect the levels and posttranslational modifications of Bcl-2 family proteins. Recent work has defined specific roles for different Bcl-2 proteins in the disruption of mitochondrial function that leads to cell death. Using this understanding of Bcl-2 protein function as a framework, we will consider the molecular mechanisms of apoptosis induced by integrin detachment (anoikis) and cell death stimulated by the loss of cytoskeletal architecture (amorphosis).
authors.affiliation: Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur-NRB 356, Boston, MA 02115, USA. smartin@genetics.med.harvard.edu
authors.forename: Stuart S
authors.initials: SS
authors.lastname: Martin
authors.forename: Kristiina
authors.initials: K
authors.lastname: Vuori
mesh_terms: D000818:Animals; D023102:Anoikis / Q000502:physiology*; D051023:BH3 Interacting Domain Death Agonist Protein; D002352:Carrier Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000502:physiology*; D004789:Enzyme Activation; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D053219:Receptors, Tumor Necrosis Factor, Member 25; D051028:bcl-2-Associated X Protein
chemical_list: D051023:BH3 Interacting Domain Death Agonist Protein; C494814:BID protein, human; D002352:Carrier Proteins; D016023:Integrins; D019253:Proto-Oncogene Proteins c-bcl-2; D018124:Receptors, Tumor Necrosis Factor; D053219:Receptors, Tumor Necrosis Factor, Member 25; C506033:TNFRSF25 protein, human; D051028:bcl-2-Associated X Protein