Adaptation of cardiac myocyte contractile properties to exercise training.
Recent work suggests that chronic exercise induces alterations in the contractile properties of cardiac myocytes. These alterations include increased sensitivity to activation by Ca, changes in the force-length relationship, and increased power output. A recently observed shift in expression of myosin light chain 1 subunit isoforms induced by training may provide a molecular mechanism for these contractile alterations.
Diffee
Gary M
GM
Department of Kinesiology, University of Wisconsin, Madison, WI 53706, USA. diffee@education.wisc.edu
D000222:Adaptation, Physiological; D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D048429:Cell Size / Q000187:drug effects; D006321:Heart / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats
D002118:Calcium