Protective effects of mutant ubiquitin in transgenic mice.
The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and it is not unreasonable to expect that such benefits will include diseases of aging.
Gray
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DA
Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada. dgray@ohri.ca
Tsirigotis
M
M
Brun
J
J
Tang
M
M
Zhang
M
M
Beyers
M
M
Woulfe
J
J
D000375:Aging; D000818:Animals; D001831:Body Temperature; D001835:Body Weight; D002945:Cisplatin / Q000494:pharmacology; D003546:Cysteine Endopeptidases / Q000378:metabolism; D004249:DNA Damage; D051379:Mice; D008822:Mice, Transgenic; D009097:Multienzyme Complexes / Q000378:metabolism; D009154:Mutation; D046988:Proteasome Endopeptidase Complex; D012190:Retroviridae / Q000235:genetics; D013997:Time Factors; D025801:Ubiquitin / Q000235:genetics* / Q000378:metabolism
D009097:Multienzyme Complexes; D025801:Ubiquitin; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D002945:Cisplatin