title: Ca2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing.
abstract: Normal brain ageing is associated with a degree of functional impairment of neuronal activity that results in a reduction in memory and cognitive functions. One mechanism proposed to explain the age-dependent changes was the "Ca(2+) hypothesis of ageing" but data accumulated in the last decade revealed a number of inconsistencies. Two important questions were raised: (a) which are, if any, the most reliable age-associated change in neuronal Ca(2+) homeostasis and (b) are these changes primary, and thus determinant of the ageing phenotype, or are they secondary to other changes in the physiology of the aged neurones. After a brief review of the evidence accumulated for the age-induced changes in synaptic plasticity, we assess the proposal that these changes are, ultimately, determined by changes in the metabolic state of the aged neurones, that are manifest particularly after neuronal stimulation. In this context, it appears that the changes in mitochondrial status and function are of primary importance.
authors.affiliation: Dept. Physiology, Division of Medical Sciences, The University of Birmingham, Edgbaston, B15 2TT, United Kingdom. e.c.toescu@bham.ac.uk
authors.forename: E C
authors.initials: EC
authors.lastname: Toescu
authors.forename: A
authors.initials: A
authors.lastname: Verkhratsky
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D009473:Neuronal Plasticity; D013569:Synapses / Q000502:physiology*
chemical_list: D002118:Calcium