title: Effects of intestinal electrical stimulation on intestinal dysrhythmia and symptoms in dogs.
abstract: The aim of this study was to investigate the effect of intestinal electrical stimulation on small intestinal dysrhythmia and motion sickness-like symptoms induced by vasopressin. Female dogs chronically implanted with two pairs of electrodes on jejunum serosa were used in a four-session study. Saline and vasopressin were infused in sessions 1 and 2, respectively. Sessions 3 and 4 were the same as session 2, except a long- or short-pulse intestinal electrical stimulation was applied on the proximal pair of electrodes. Intestinal slow waves and motion sickness-like symptoms were recorded in each session. Results were as follows. (1) Vasopressin induced intestinal dysrhythmia, uncoupling of slow waves, and vomiting and motion sickness-like symptoms (P < 0.05, ANOVA). (2) Intestinal electrical stimulation with long pulses, but not short pulses, was capable of preventing vasopressin-induced intestinal dysrhythmia. (3) Intestinal electrical stimulation with short pulses, but not long pulses, prevented vomiting and the motion sickness-like symptoms. It is concluded that vasopressin induces intestinal dysrhythmia. Long-pulse intestinal stimulation normalizes vasopressin-induced intestinal slow-wave abnormalities with no improvement in symptoms. Short-pulse stimulation prevents emetic symptoms induced by vasopressin but has no effect on slow waves. These data suggest different mechanisms involved with different methods of intestinal stimulation.
authors.affiliation: Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas 77555-0632, USA.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
authors.forename: Lijie
authors.initials: L
authors.lastname: Wang
authors.forename: J D Z
authors.initials: JD
authors.lastname: Chen
mesh_terms: D000818:Animals; D004285:Dogs; D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D005260:Female; D007410:Intestinal Diseases / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy; D009041:Motion Sickness / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy*; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000009:adverse effects*; D014667:Vasopressins / Q000009:adverse effects*
chemical_list: D014662:Vasoconstrictor Agents; D014667:Vasopressins