Radiation-induced glioblastoma multiforme in two adult baboons (Papio cynocephalus anubis).
A diagnosis of glioblastoma multiforme (GBM) was made for cerebral masses found at necropsy in two baboons (Papio cynocephalus anubis). Case 1 was an adult (6.18 years old) male baboon that suddenly died during a physical examination as part of a clinical evaluation for a leg lameness. Case 2 was an adult (5.95 years old) female baboon that stopped breathing during anesthesia for an magnetic resonance imaging to evaluate lethargy, weight loss, inappetence, and dilated pupils. Both animals had undergone total body irradiation with cobalt during a research protocol. The incidence of spontaneous brain tumors in nonhuman primates is low, but radiation-induced GBM lesions in rhesus macaques (Macaca mulatta) have been reported. A definitive diagnosis was made in these cases, using histopathologic criteria of cellular pleomorphism, high mitotic rate, regions of coagulation necrosis, and endothelial proliferation.
Schielke
Jo Ellen
JE
Washington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Kiem
Hans-Peter
HP
Liggitt
Denny
D
Bielefeldt-Ohmann
Helle
H
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005909:Glioblastoma / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D007794:Lameness, Animal; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000662:veterinary*; D010215:Papio; D018419:Primate Diseases / Q000473:pathology*; D015303:Simian T-lymphotropic virus 1 / Q000276:immunology / Q000302:isolation & purification
D000914:Antibodies, Viral