title: Fourier components of inhomogeneously broadened water resonances in breast: a new source of MRI contrast.
abstract: High spectral and spatial resolution (HiSS) MR data were acquired at 1.5 T using echo-planar spectroscopic imaging from patients with suspicious breast lesions. The water resonances in small voxels are inhomogenously broadened and often have distinct components. Images were calculated with intensity proportional to the Fourier components of the water resonance in each voxel at different offsets from the peak frequency. The results demonstrate that in breast the off-peak Fourier component images of water are qualitatively different from those derived from the peak height of the water resonance. These differences most likely reflect underlying anatomy or physiology. In conventional images, the superposition of the various Fourier components of the water signal may cause loss of detail. The synthesis of water Fourier component images from high spectral and spatial resolution data may provide a new form of contrast, and increase sensitivity to subvoxel physiology and anatomy.
authors.affiliation: Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Milica
authors.initials: M
authors.lastname: Medved
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Newstead
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fan
authors.forename: Weiliang
authors.initials: W
authors.lastname: Du
authors.forename: Yiping P
authors.initials: YP
authors.lastname: Du
authors.forename: Peter M
authors.initials: PM
authors.lastname: MacEneaney
authors.forename: Rita M
authors.initials: RM
authors.lastname: Culp
authors.forename: Frederick
authors.initials: F
authors.lastname: Kelcz
authors.forename: Olufunmilayo I
authors.initials: OI
authors.lastname: Olopade
authors.forename: Marta A
authors.initials: MA
authors.lastname: Zamora
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Karczmar
mesh_terms: D001834:Body Water; D001941:Breast Diseases / Q000175:diagnosis*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*