title: Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice.
abstract: The effect of corosolic acid (CA) on blood glucose was studied in KK-Ay mice, an animal model of type 2 diabetes. CA (10 mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4 h after single oral administration when compared with the control group. However, CA did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density microsomal membrane to plasma membrane was significantly increased in the orally CA-treated mice when compared with that of the controls (p<0.05). These results suggest that the hypoglycemic effect of CA is derived, at least in part, from an increase in GLUT4 translocation in muscle. Therefore, it may be that CA has beneficial effects on hyperglycemia in type 2 diabetes.
authors.affiliation: Department of Clinical Nutrition, Suzuka University Medical Science, Mie, Japan. miura@suzuka-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Miura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Itoh
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kaneko
authors.forename: Naoya
authors.initials: N
authors.lastname: Ueda
authors.forename: Torao
authors.initials: T
authors.lastname: Ishida
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Fukushima
authors.forename: Futoshi
authors.initials: F
authors.lastname: Matsuyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000235:genetics*; D004195:Disease Models, Animal; D051275:Glucose Transporter Type 4; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D009004:Monosaccharide Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics* / Q000378:metabolism*; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D051275:Glucose Transporter Type 4; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495693:Slc2a4 protein, mouse; D014315:Triterpenes; C113861:corosolic acid