Exploiting tolerance processes in transplantation.
The full potential of organ transplantation has not yet been realized because of the hazards associated with the long-term use of immunosuppressive drugs. Modern research into mechanisms of immune tolerance offers the promise of reprogramming the immune system, so as to harness the body's natural tolerance mechanisms in the service of graft acceptance. This would allow the minimization of immunosuppressive treatment and offers the prospect of eventually weaning transplant recipients off their drugs.
Waldmann
Herman
H
Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK. herman.waldmann@path.ox.ac.uk
Cobbold
Stephen
S
D000818:Animals; D015415:Biomarkers; D016026:Bone Marrow Transplantation; D006082:Graft Enhancement, Immunologic; D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology; D018183:Transplantation Chimera; D019172:Transplantation Conditioning; D014181:Transplantation Immunology; D023001:Transplantation Tolerance
D015415:Biomarkers; D007166:Immunosuppressive Agents