Reduction in testosterone concentration and its effect on the reproductive output of chronic malaria-infected male mice.
An experimental host-parasite association involving BALB/c male mice infected with Plasmodium chabaudi chabaudi was used in order to investigate the influence of the parasite on the sexual physiology and behavior of infected hosts. Infected males displayed complete courtship behavior leading to ejaculation and sired litters on several occasions. A weekly assay of testosterone and corticosterone plasma concentrations revealed a twofold decrease in the testosterone level at 4 and 5 weeks post-injection, during recrudescence. This imbalance was accompanied by a decrease in the overall duration of the social investigation contacts occurring during courtship and by a reduction in the fertilization rate of the infected animals. These physiological perturbations can be regarded as an adaptive response of the host to the recrudescing parasites, which illustrates the rodents' capacity for regulating the testosterone profiles needed to balance the competing demands of immunity and reproduction.
Barthelemy
Mathieu
M
Laboratoire de Parasitologie Evolutive CNRS UMR 7103, Université Pierre et Marie Curie, 9 Quai Saint Bernard, Case 175, 75252, Paris Cedex 05, France. Mathieu.Barthelemy@snv.jussieu.fr
Gabrion
Claude
C
Petit
Gilles
G
D000818:Animals; D003345:Corticosterone / Q000097:blood; D006790:Host-Parasite Interactions / Q000502:physiology; D008288:Malaria / Q000097:blood / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016788:Plasmodium chabaudi; D012098:Reproduction / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology; D013739:Testosterone / Q000097:blood* / Q000502:physiology; D014828:Vocalization, Animal
D013739:Testosterone; D003345:Corticosterone