[HIV-infection and its implications on allergic diseases].
BACKGROUND
In 1980 AIDS appeared in the USA in the homosexual community. CHARACTERISTICS OF THE VIRUS: A particle of HIV is formed by two identical RNA chains that are packed within a center of viral proteins, and surrounded by a double layer of fosfolipids derived from the cellular membrane of the host.


METHODS
It starts with a severe infection, evolving in a progressive chronic infection reaching a final phase with a T CD4+ cellular count under 200 cells per mm3, with incident infections, neoplasias, consumption syndrome, renal dysfunction, and degeneration of the central system. CONSEQUENCES IN ALLERGIC REACTION: Reactions to the use of drugs are the most frequent form of hypersensitivity caused by HIV compared to the general population. In this condition, a profile of TH2 cytocines are produced and they induce the synthesis of IgE against the drugs. IgE levels have been related to the progression of this condition.


CONCLUSIONS
The increase of IgE is a risk factor to allergic reactions against these medications, as well as a severity index.
Montero Mora
Patricia
P
Servicio de alergia e inmunología clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, col. Doctores, CP 06720, México, DF.
Suárez Núñez
Francisco
F
Tinajero Castañeda
Olga Adriana
OA
González Pérez
María del Carmen
Mdel C
Guidos Fogelbach
Guillermo Arturo
GA
D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology