[Neuroprotective effects of topiramate].
Topiramate (TPM) is a new anti-convulsant drug, prescribed in epileptic seizure. Pharmacological actions of TPM are: a) a positive modulation of GABA receptors; b) inhibition of the kainite and aminohydroxymethylisoxazole propionic acid (AMPA) glutamate receptor sub-types; c) a use-dependent Na+ channel blocker. Recent studies suggest that TPM can have anti-excitotoxic properties, because it protects against motor neuron degeneration. Moreover, TPM enhances neuroprotection and reduces hemorrhagic incidence in focal cerebral ischemia.
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Sezione Sclerosi Multipla e Malattie Demielinizzanti, Università di Catania, Italia. pange.bel@virgilio.it
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D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015222:Sodium Channels / Q000187:drug effects; D000077236:Topiramate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000037:antagonists & inhibitors
D000927:Anticonvulsants; D018696:Neuroprotective Agents; D015222:Sodium Channels; D000077236:Topiramate; D005632:Fructose; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid