[Melt granulation with glyceryl palmitostearate to obtain taste-masked acetaminophen].
A melt granulation process designed to obtain a taste-masked acetaminophen using glyceryl palmitostearte (Precirol Ato 5) is described. Melting this lipid material in a high-smear mixer gives granules which can be directly compressed after blending with the required excipients. The phase diagram shows the absence of interaction between the phases of the two components and no effect on acetaminophen polymorphism. A water dispersible tablet formulation is proposed for oral administration of cristallized acetominophen (500 mg) devoid of bitterness of which 90% dissolves within 15 minutes.
Duru
C
C
Laboratoire de Pharmacie galénique, pharmacotechnie et biopharmacie, Université Montpellier I.
Boudeville
Ph
P
Delalonde
M
M
Farah
N
N
D000082:Acetaminophen / Q000008:administration & dosage* / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000009:adverse effects; D004339:Drug Compounding; D005079:Excipients; D005989:Glycerides; D006801:Humans; D010168:Palmitates; D011208:Powders; D013607:Tablets; D013649:Taste
D018712:Analgesics, Non-Narcotic; D005079:Excipients; D005989:Glycerides; D010168:Palmitates; D011208:Powders; D013607:Tablets; C048159:glyceryl monostearate; D000082:Acetaminophen