PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways.
The phosphoinositide 3-kinase related kinases (PIKKs) comprise a family of high molecular mass signaling proteins that play central roles in the control of cell growth, gene expression, and genome surveillance and repair in eukaryotic cells. Mammalian cells express six PIKK family members, five of which-ATM, ATR, mTOR, DNA-PK, and hSMG-1-function as protein serine-threosine kinases. This overview provides some general insights into the pharmacology, biochemistry, and function of this nonconventional group of protein kinases.
Abraham
Robert T
RT
Program in Signal Transduction Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92130, USA. abraham@burnham.org
D020816:Amino Acid Motifs; D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins; D006801:Humans; D008957:Models, Genetic; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000502:physiology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins
D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human