Reproductive performance of couples discordant for hepatitis B and C following IVF treatment.
OBJECTIVE
To examine the reproductive performance of hepatitis B (HBV) and C (HCV) discordant couples following IVF-ET.


METHODS
A retrospective cohort study of 25 IVF-ET cycles in HBV and HCV discordant couples was performed. Thirteen patients in the study cohort were discordant for HBV (10 males and 3 females), and 12 (9 males and 3 females) for HCV. Twenty-seven consecutive age matched patients comprised the control group. All patients underwent controlled ovarian hyperstimulation using the long downregulation protocol followed by IVF or ICSI.


RESULTS
Patients in the three groups (HBV, HCV, and controls) had similar ages, and day 3 FSH concentrations. Despite comparable response to COH, and similar fertilization, and cleavage rates in the three groups, couples discordant for HBV or HCV had significantly poorer implantation and pregnancy rates (7.7%, 0% respectively) compared with controls (41%).


CONCLUSIONS
Despite comparable response to COH, HBV and HCV positive discordant couples, have significantly lower implantation and pregnancy rates compared with age-matched controls.
Department of Obstetrics and Gynecology, McGill Reproductive Center, McGill University, Montreal, Canada. imran.pirwany@mail.mcgill.ca
Imran R
IR
Pirwany
Simon
S
Phillips
Simon
S
Kelly
William
W
Buckett
Seang Lin
SL
Tan
D000328:Adult; D015331:Cohort Studies; D010064:Embryo Implantation; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis; D006509:Hepatitis B / Q000235:genetics*; D006526:Hepatitis C / Q000235:genetics*; D006801:Humans; D007246:Infertility / Q000628:therapy / Q000821:virology*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D016896:Treatment Outcome
D005640:Follicle Stimulating Hormone