Treatment strategies for perianal rhabdomyosarcoma: report of two cases.
Intensive chemotherapy and high-dose radiation with complete excision of the tumor are the treatment of choice for rhabdomyosarcoma (RMS). However, because there are so few reports of perianal RMS, a mainstream treatment has not been established. We report two cases of perianal RMS and review 13 cases documented in Japan since 1990. Case 1 was a 7-year-old boy first treated by tumor excision followed by chemotherapy and external irradiation. He has since been tumor-free but suffered severe perianal erosion and ulceration. Case 2 was a 17-year-old girl first treated by preoperative chemotherapy to reduce the tumor size, after which the tumor was completely excised with anatomical guidance using three-dimensional computed tomography via the posterior sagittal approach, followed by open intraoperative irradiation. She has since been tumor-free with preserved anal function. These case reports show the importance of cogitated treatments for preservation of anal function and optimal therapeutic outcome in patients with perianal RMS.
Watanabe
Yoshio
Y
Department of Surgery, Ogaki Municipal Hospital, Ogaki, Japan.
Yamaguchi
Akihiro
A
Isogai
Masatoshi
M
Kaneoka
Yuji
Y
Suzuki
Masahiko
M
Ando
Hisami
H
Horibe
Keizo
K
D000293:Adolescent; D001005:Anus Neoplasms / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D011182:Postoperative Care; D011300:Preoperative Care; D018232:Rhabdomyosarcoma, Alveolar / Q000453:epidemiology / Q000628:therapy*; D018233:Rhabdomyosarcoma, Embryonal / Q000453:epidemiology / Q000628:therapy*