Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2=salicylic acid).
[Ag(2)(NH(3))(2)(salH)(2)] (salH(2)=salicylic acid) was synthesised from salicylic acid and Ag(2)O in concentrated aqueous NH(3) and the dimeric Ag(I) complex was characterised using X-ray crystallography. The complex is centrosymmetric with each metal coordinated to a salicylate carboxylate oxygen and to an ammonia nitrogen atom in an almost linear fashion. The two [Ag(NH(3))(salH)] units in the complex are linked by an Ag-Ag bond. Whilst metal-free salH(2) did not prevent the growth of the fungal pathogen Candida albicans [Ag(2)(NH(3))(2)(salH)(2)], [Ag(2)(salH)(2)] and some simple Ag(I) salts greatly inhibited cell reproduction. SalH(2), [Ag(2)(NH(3))(2)(salH)(2)] [Ag(2)(salH)(2)] and AgClO(4) produced a dose-dependent cytotoxic response against the three human derived cancer cell lines, Cal-27, Hep-G2 and A-498, with the Ag(I)-containing reagents being the most effective.
Chemistry Department, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
Barry
B
Coyle
Malachy
M
McCann
Kevin
K
Kavanagh
Michael
M
Devereux
Vickie
V
McKee
Nijhuma
N
Kayal
Denise
D
Egan
Carol
C
Deegan
Gregory J
GJ
Finn
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D002176:Candida albicans / Q000378:metabolism; D002177:Candidiasis / Q000188:drug therapy; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use; D020156:Salicylic Acid / Q000737:chemistry / Q000627:therapeutic use; D018030:Silver Compounds / Q000737:chemistry / Q000627:therapeutic use
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D018030:Silver Compounds; D020156:Salicylic Acid