Perceptual illusion of "paradoxical heat" engages the insular cortex.
Paradoxical heat (PH), the illusion of skin heat, accompanies many neurological disorders. Using the technique of percept-related functional MRI, we found a region of the right insular cortex specifically activated when subjects perceive a heat sensation in their right hand even though their skin temperature is cool or at neutral. This region was suppressed during mild skin cooling. We propose that this differential response is a manifestation of the role of the insula in signaling temperature perceptions regardless of the actual temperature of the skin. These findings suggest that a region within the insula has a complex role in heat perception, perhaps contributing to a specific, rather than general, thermosensory perception. These data provide insight to our basic understanding of normal and pathological thermosensory perceptions.
Toronto Western Hospital, MP14-306, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada. kdavis@uhnres.utoronto.ca
K D
KD
Davis
G E
GE
Pope
A P
AP
Crawley
D J
DJ
Mikulis
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D006225:Hand / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D007088:Illusions / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012677:Sensation / Q000502:physiology; D012881:Skin Temperature; D013697:Thermosensing / Q000502:physiology*