Finding and keeping your partner during meiosis.
HIM-3 is a meiosis-specific protein that localizes to the cores of chromosomes from the earliest stages of prophase I until the metaphase to anaphase I transition in Caenorhabditis elegans. him-3 mutations disrupt homolog alignment, synapsis, and recombination and we propose that the association of HIM-3 with chromosome axes is a critical event in meiotic chromosome morphogenesis that is required for the proper coordination of these processes. The presence of HIM-3-like proteins in other eukaryotes, some of which are known to be required for synapsis and recombination, suggests the existence of a conserved class of axis-associated proteins that function at the junction of essential meiotic processes.
Department of Biology, McGill University, Montreal, Quebec, Canada.
Florence
F
Couteau
Will
W
Goodyer
Monique
M
Zetka
D000595:Amino Acid Sequence; D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry; D006801:Humans; D008540:Meiosis / Q000502:physiology*; D008969:Molecular Sequence Data
D029742:Caenorhabditis elegans Proteins; C121599:HIM-3 protein, C elegans