Hematologic differences in heterophile-positive and heterophile-negative infectious mononucleosis.
Infectious mononucleosis (IM) due to all causes is characterized by atypical lymphocytosis. We sought to compare hematologic parameters of infectious mononucleosis due to Epstein-Barr virus (EBV) infection (heterophile antibody (HA) positive) with mononucleosis due to other causes. Mono-Latex Slide Agglutination Test results and complete blood counts (CBC) of 147 patients with mononucleosis were retrospectively analyzed. Leukocyte count, absolute lymphocyte count, and presence of atypical lymphocytes in EBV-positive and EBV-negative groups were statistically compared. We analyzed 68 EBV-positive and 79 EBV-negative cases. EBV-positive patients were significantly younger than EBV-negative patients were. Mean total WBC count and mean absolute lymphocyte count were significantly higher in EBV-positive patients. Absolute lymphocytosis, absolute leukocytosis, and atypical lymphocytosis were also significantly more frequent in EBV-positive patients. Leukopenia was more frequently seen in EBV-negative patients.
Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston 77555, USA.
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Ventura
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Hudnall
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000910:Antibodies, Heterophile / Q000097:blood*; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007244:Infectious Mononucleosis / Q000097:blood* / Q000145:classification / Q000276:immunology / Q000821:virology; D007841:Latex Fixation Tests; D007958:Leukocyte Count; D007970:Leukopenia / Q000209:etiology; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000473:pathology; D008218:Lymphocytosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D000910:Antibodies, Heterophile