Severe metabolic acidosis and renal failure in an HIV-1 patient receiving tenofovir.
A 55-y-old male developed severe metabolic acidosis and renal failure during tenofovir therapy. Increased tenofovir exposure due to low body weight and chronic stable renal insufficiency could have enhanced the risk of nephrotoxicity, and creatinine clearance should be estimated before initiation of tenofovir.
Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Denmark. rh11788@rh.dk
Ann-Brit Eg
AB
Hansen
Sofie
S
Mathiesen
Jan
J
Gerstoft
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D000225:Adenine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D011379:Prognosis; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index; D000068698:Tenofovir
D063065:Organophosphonates; D009943:Organophosphorus Compounds; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; D000225:Adenine