New cytotoxic cembranes from the sea pen Gyrophyllum sibogae.
Two new cembrane-type diterpenoids have been isolated from the 2-propanol extract of the sea pen Gyrophyllum sibogae collected in South Africa: 7,8-dihydroflabellatene A (1) and 7,8-dihydroflabellatene B (2). Their structures were determined on the basis of detailed spectroscopic analysis and by single-crystal X-ray analysis of the major metabolite 1, which showed strong in vitro cytotoxicity against a panel of 13 tumor cell lines.
Drug Discovery Department, PharmaMar S.A., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. jfreyes@pharmamar.com
Fernando
F
Reyes
Ana
A
Ardá
Rocío
R
Martín
Rogelio
R
Fernández
Ana
A
Rueda
David
D
Montalvo
Cristina
C
Gómez
Carlos
C
Jiménez
Jaime
J
Rodríguez
José Maria
JM
Sánchez-Puelles
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008270:Madagascar; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014407:Tumor Cells, Cultured
C488778:7,8-dihydroflabellatene A; C488779:7,8-dihydroflabellatene B; D000970:Antineoplastic Agents; D004224:Diterpenes