Independent lesions of fixed drug eruption caused by trimethoprim-sulfamethoxazole and tenoxicam in the same patient: a rare case of polysensitivity.
Polysensitivity in fixed drug eruption is a rare finding that occurs because of chemically unrelated drugs. In cases of polysensitivity, the lesions may occur on identical or separate sites, the latter indicating the role of antigen-specific mechanisms in the site-specificity of fixed drug eruption. I herein report a patient with separate site involvement induced by trimethoprim-sulfamethoxazole and tenoxicam, a drug combination that has not been reported before. Reactivation of old trimethoprim-sulfamethoxazole-specific lesions after a long resting period was another striking feature.
Department of Dermatology, Istanbul University, Istanbul Medical Faculty, Turkey. bayazit@turk.net
Esen
E
Ozkaya-Bayazit
D002081:Buttocks; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D005528:Foot; D006225:Hand; D006261:Headache / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D010894:Piroxicam / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D012882:Skin Tests; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000009:adverse effects*
D010894:Piroxicam; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; C032801:tenoxicam