Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis.
The goal of systems biology is to define all of the elements present in a given system and to create an interaction network between these components so that the behavior of the system, as a whole and in parts, can be explained under specified conditions. The elements constituting the network that influences the development of atherosclerosis could be genes, pathways, transcript levels, proteins, or physiologic traits. In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks.
Ghazalpour
Anatole
A
Department of Human Genetics, Molecular Biology Institute, University of California-Los Angeles, Los Angeles, CA 90095-1679, USA.
Doss
Sudheer
S
Yang
Xia
X
Aten
Jason
J
Toomey
Edward M
EM
Van Nas
Atila
A
Wang
Susanna
S
Drake
Thomas A
TA
Lusis
Aldons J
AJ
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D015870:Gene Expression; D023281:Genomics / Q000379:methods; D006801:Humans; D040901:Proteomics / Q000379:methods; D049490:Systems Biology