Age-related changes in treatment strategies for acute myocardial infarction: a population-based study.
OBJECTIVE
To compare across four age groups (<65, 65-74, 75-84, > or =85) the determinants of coronary reperfusion therapy (CRT) use in ST-segment elevation acute myocardial infarction (STE-AMI).


METHODS
Population-based, observational study.


METHODS
Performed in the health district of Florence, Italy, where percutaneous coronary intervention (PCI) is the preferred CRT.


METHODS
Nine hundred thirty patients with STE-AMI prospectively enrolled in the Florence AMI registry.


METHODS
Use of CRT, clinical factors associated with CRT use.


RESULTS
CRT use was reduced from 71% at younger than 65 to 31% at aged 85 and older (P<.001). After adjusting for chronic comorbidity, Killip class, admission hospital category, hospitalization delay, and AMI location, CRT use was 29% (P=.17) lower at age 75 to 84 and 63% (P<.001) lower at age 85 and older than at younger than 65. Within each age group, the probability of receiving CRT was three to five times greater in patients directly admitted to the hospital with PCI facilities. Acute cardiac failure and chronic comorbidity were associated with lower CRT use only in patients aged 65 and older. Patients aged less than 85 years who received reperfusive therapy had a significantly lower risk of death (-44%, P=.045) at 1 year, whereas it was less evident and nonsignificant (-27%, P=.27) in patients aged 85 and older.


CONCLUSIONS
Results confirm that, although they might substantially benefit from CRT during STE-AMI, older patients are excluded from CRT even when eligible. This further indicates that clinicians are not yet completely prepared to manage most efficiently frail elderly with AMI, a task requiring a specific interdisciplinary training program in geriatric cardiology.
Barchielli
Alessandro
A
Epidemiology Unit, Azienda Sanitaria di Firenze, Florence, Italy. alessandro.barchielli@asf.toscana.it
Buiatti
Eva
E
Balzi
Daniela
D
Santoro
Giovanni M
GM
Carrabba
Nazario
N
Fabiani
Plinio
P
Maci
Marcella
M
Margheri
Massimo
M
Mangani
Irene
I
Monami
Matteo
M
Marchionni
Niccolò
N
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000628:therapy*; D015425:Myocardial Reperfusion