Synthesis of polycyclic aromatic iodides via ICl-induced intramolecular cyclization.
The reaction of 2-(arylethynyl)biphenyls with ICl at -78 degrees C affords substituted polycyclic aromatic iodides in good to excellent yields. The aryl substituents can be either electron-donating or electron-withdrawing groups such as OMe, Me, CHO, CO(2)Et or NO(2) groups. This chemistry has been successfully extended to systems containing a variety of polycyclic and heterocyclic rings. [reaction: see text]
Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
Tuanli
T
Yao
Marino A
MA
Campo
Richard C
RC
Larock