TCR signaling: another Abl-bodied kinase joins the cascade.
Protein tyrosine kinases have long been recognized as the most proximal actors in T-cell antigen receptor (TCR) signaling. Three non-receptor tyrosine kinase families (Src, ZAP-70 and Tec) are known to be critical, but a new study now shows that room needs to be made in this pathway for yet another protein tyrosine kinase family - Abl/Arg.
Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Gerontology Research Center, Baltimore, Maryland 21224-6825, USA. WangeR@grc.nia.nih.gov
Ronald L
RL
Wange
D048868:Adaptor Proteins, Signal Transducing; D001549:Benzamides; D002352:Carrier Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D000068877:Imatinib Mesylate; D008213:Lymphocyte Activation / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D010879:Piperazines / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D051746:ZAP-70 Protein-Tyrosine Kinase
D048868:Adaptor Proteins, Signal Transducing; D001549:Benzamides; D002352:Carrier Proteins; C110810:LAT protein, human; D008565:Membrane Proteins; D010750:Phosphoproteins; D010879:Piperazines; D011743:Pyrimidines; D011948:Receptors, Antigen, T-Cell; C092947:SLP-76 signal Transducing adaptor proteins; D000068877:Imatinib Mesylate; C426236:ARG tyrosine kinase; D011505:Protein-Tyrosine Kinases; D051746:ZAP-70 Protein-Tyrosine Kinase; C497261:ZAP70 protein, human