Measurement of polynuclear aromatic hydrocarbons in canine lung after alkaline decomposition.
An alkaline decomposition method employing a KOH/alcohol solution was studied, and polynuclear aromatic hydrocarbons (PAHs) contained in particles remaining in canine lung were measured. As a result, BaA, BkF, BaP, and BghiP were found. By this method, PAHs extracted from the lungs of 32 dogs were 13.0-166.0 ng (mean, 63.0 ng) for BaA, 6.6-90.2 ng (mean, 27.4 ng) for BkF, 9.8-167.4 ng (mean 47.2 ng) for BaP, and 10.8-206.0 ng (mean, 61.8 ng) for BghiP. The results showed no correlation between the age and the concentration of PAHs in the lung, but some correlation was found between the age and the lung weight (p<0.01). There were significant correlations among the concentrations of the compounds in the lung (p<0.01). These results suggest that dogs, like humans, are affected by automobile exhaust and other common generation sources of such substances.
Department of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
Yukihiko
Y
Takagi
Kazutoshi
K
Sugita
Makoto
M
Muto
Yukio
Y
Kato
Ken-ichi
K
Kohzaki
Osamu
O
Endo
Sumio
S
Goto
D000367:Age Factors; D000393:Air Pollutants; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004285:Dogs; D004784:Environmental Monitoring; D006878:Hydroxides / Q000494:pharmacology; D008168:Lung / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis* / Q000302:isolation & purification; D017680:Potassium Compounds / Q000494:pharmacology; D001335:Vehicle Emissions / Q000633:toxicity
D000393:Air Pollutants; D006878:Hydroxides; D011084:Polycyclic Aromatic Hydrocarbons; D017680:Potassium Compounds; D001335:Vehicle Emissions; C029943:potassium hydroxide