Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence.
Myocardial hypertrophy is a response of cardiac muscle to altered conditions of haemodynamic overload caused by a large number of physiological and pathological conditions. Traditionally, it has been considered a beneficial mechanism. However, sustained hypertrophy has been associated with a significant increase in the risk of cardiovascular disease and mortality. Actually, many researchers are trying to understand whether left ventricular hypertrophy is a 'good' mechanism to stimulate or a 'bad' process to prevent. In this review we investigate the most common biochemical signaling pathways involved in the hypertrophic response to identify the precise role, either 'adaptive' or 'maladaptive', of each molecular pathway. Delinealing intracellular signaling pathways involved in the different aspects of cardiac hypertrophy will permit future improvements in the signaling that controls beneficial growth.
Selvetella
Giulio
G
Department of Angiocardioneurology, I.R.C.C.S. "Neuromed", "La Sapienza" University of Rome, 86077 Pozzilli (IS), Italy.
Hirsch
Emilio
E
Notte
Antonella
A
Tarone
Guido
G
Lembo
Giuseppe
G
D000222:Adaptation, Physiological; D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D020257:Ventricular Remodeling
D019869:Phosphatidylinositol 3-Kinases; D019703:Calcineurin