Pulmonary fibrosis: thinking outside of the lung.
Pulmonary fibrosis is a devastating condition that leads to progressive lung destruction and scarring. Previous mechanistic research has focused on the local fibroproliferative process in the lung. However, emerging evidence suggests that circulating cells of hematopoietic origin play a crucial role in the pathogenesis of this disease.
Garantziotis
Stavros
S
Department of Medicine at Duke University Medical Center, Durham, North Carolina 27710, USA.
Steele
Mark P
MP
Schwartz
David A
DA
D000818:Animals; D001761:Bleomycin / Q000633:toxicity; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury; D008954:Models, Biological; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D014945:Wound Healing
D001761:Bleomycin