Effects of acupuncture on myelogenic osteoclastogenesis and IL-6 mRNA expression.
The effect of acupuncture and moxibustion on myelogenic osteoclastogenesis and IL-6 mRNA expression is investigated. The result turns to be that the number of myelogenic osteoclasts in the model group is obviously bigger than in the sham operation group (P<0.01), and that in the acupuncture group is markedly smaller than in the model group (P<0.01). The IL-6 mRNA expression in the marrow cells of the model group is significantly elevated, as compared with that in the sham operation group (P<0.01), while the its elevation is lower in the acupuncture group than in the model group (P<0.01). It is therefore concluded that 1) acupuncture effectively modulates the secretion of and then to reduces IL-6 mRNA expression and 2) acupuncture decreases the number of myelogenic osteoclasts.
Fujian TCM College, Fuzhou, 350003.
Xianxiang
X
Liu
Lin
L
Shen
Mingxia
M
Wu
Binghuang
B
Wu
Lan
L
Gao
Wensheng
W
Hu
Anzhen
A
Zhang
D026881:Acupuncture; D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism; D001862:Bone Resorption; D005260:Female; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D009071:Moxibustion; D010010:Osteoclasts / Q000473:pathology* / Q000502:physiology; D010012:Osteogenesis; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D010052:Ovariectomy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D015850:Interleukin-6; D012333:RNA, Messenger