Modulation of adaptive immune responses by sphingosine-1-phosphate.
Sphingosine-1-phosphate (S1P) has long been recognized as a mediator of a variety of cell functions. A growing body of evidence has accumulated demonstrating its role in cell migration and as a mediator of growth factor-induced events. In recent years, it has become apparent that S1P also mediates many cytokine and chemokine functions. Cells of the immune system function and migrate in response to a complex network of cytokines and chemokines, and the outcome is determined by the interplay of the effects of these molecules on the target cell. S1P may be a bona fide component of these networks and influence the responses of cells to these immune modulators.
Payne
Shawn G
SG
Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond 23298, USA.
Milstien
Sheldon
S
Barbour
Suzanne E
SE
Spiegel
Sarah
S
D000818:Animals; D016207:Cytokines / Q000502:physiology; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007107:Immune System / Q000276:immunology*; D008246:Lysophospholipids / Q000276:immunology / Q000502:physiology*; D011409:Propylene Glycols / Q000494:pharmacology; D049349:Receptors, Lysosphingolipid / Q000819:agonists / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000276:immunology / Q000502:physiology*
D016207:Cytokines; D008246:Lysophospholipids; D011409:Propylene Glycols; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine