Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine.
Feeding stemmadenine to Catharanthus roseus cell suspension culture resulted in the accumulation of catharanthine, tabersonine and condylocarpine. Condylocarpine is not an intermediate in the pathway to catharanthine or tabersonine when it is fed to the cultures. The results support the hypothesis that stemmadenine is an intermediate in the pathway to catharanthine and tabersonine.
Department of Pharmacognosy, Section of Metabolomics, Institute of Biology Leiden, Leiden University, The Netherlands.
Magdi
M
El-Sayed
Young H
YH
Choi
M
M
Frédérich
Sittiruk
S
Roytrakul
Rob
R
Verpoorte
D000470:Alkaloids / Q000096:biosynthesis*; D030008:Catharanthus / Q000378:metabolism*; D002478:Cells, Cultured; D026121:Indole Alkaloids / Q000493:pharmacokinetics*
D000470:Alkaloids; D026121:Indole Alkaloids; C046117:stemmadenine