[Association of HLA-DRB1*1501 polymorphism with the susceptibility to severe chronic periodontitis in Chinese Han nationality].
OBJECTIVE
To investigate the association of HLA-DRB1*1501 polymorphism with the susceptibility to severe chronic periodontitis (CP) in Chinese Han nationality.


METHODS
DNA samples were collected with buccal swabs from 134 subjects with severe chronic periodontitis and 81 periodontal healthy control. HLA-DRB1*1501 genotype was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotype distribution was statistically analyzed by chi2 test.


RESULTS
The allele frequencies of DRB1*1501 was detected more frequently in severe CP patients than in the controls [OR=3.874 (2.401-6.252), P<0.05]. The 1501/1501 genotype frequencies were significantly increased in patients compared with the reference population [OR=20.896 (4.866-89.726), P<0.05].


CONCLUSIONS
The results suggest that HLA-DRB1*1501 allele may be a risk indicator for the susceptibility to severe CP in Han nationality (P<0.05). The HLA-DRB1*1501 homozygote genotype was associated significantly with severe CP (P<0.05).
West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China.
Shao-Jun
SJ
Zhang
Ai-Ling
AL
Yang
Jin-Cai
JC
Zhang
Yun-Hui
YH
Zhang
Yan
Y
Tang
D000328:Adult; D044466:Asian People; D002681:China / Q000208:ethnology; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains