Volatile anesthetics and succinylcholine in cardiac ryanodine receptor defects.
Familial polymorphic (catecholaminergic) ventricular tachycardia is an arrhythmogenic cardiac disorder caused by mutations of the myocardial isoform of the ryanodine receptor gene (RyR2). Mutations of the corresponding gene in the skeletal muscle (RyR1) predispose its carriers to malignant hyperthermia upon use of volatile anesthetics or succinylcholine, which further deteriorate the inherited intracellular calcium release disorder. We report a series of patients with cardiac RyR defects who underwent general anesthesia without complications. Succinylcholine and volatile anesthetics did not have a clinically significant effect on RyR2 defects.
Swan
Heikki
H
Department of Cardiology, Helsinki University Hospital, PL 340, Haartmaninkatu 4, FIN-00029 HUS, Helsinki, Finland. heikki.swan@helsinki.fi
Laitinen
Päivi J
PJ
Toivonen
Lauri
L
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006321:Heart / Q000187:drug effects*; D006579:Heterozygote; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000235:genetics; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009206:Myocardium / Q000378:metabolism; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects; D019837:Ryanodine Receptor Calcium Release Channel / Q000187:drug effects / Q000235:genetics*; D013390:Succinylcholine / Q000009:adverse effects; D017180:Tachycardia, Ventricular / Q000188:drug therapy / Q000235:genetics
D018685:Anesthetics, Inhalation; D009467:Neuromuscular Depolarizing Agents; D019837:Ryanodine Receptor Calcium Release Channel; D013390:Succinylcholine