Protein kinase C and beyond.
Protein kinase C molecules regulate both positive and negative signal transduction pathways essential for the initiation and homeostasis of immune responses. There are multiple isoforms of protein kinase C that are activated differently by calcium and diacylglycerol, and these are activated mainly by antigen receptors in T cells, B cells and mast cells. Additionally, mammals express several other diacylglycerol binding proteins that are linked to a network of key signal transduction pathways that control lymphocyte biology. Diacylglycerol and protein kinase C regulate a broad range of gene transcription programs but also modulate integrins, chemokine responses and antigen receptors, thereby regulating lymphocyte adhesion, migration, differentiation and proliferation.
Spitaler
Martin
M
School of Life Sciences, Division of Cell Biology & Immunology, University of Dundee, MSI/WTB Complex, Dow Street, Dundee DD1 5EH, UK.
Cantrell
Doreen A
DA
D000818:Animals; D004075:Diglycerides / Q000276:immunology / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000187:drug effects / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D011493:Protein Kinase C / Q000187:drug effects / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*
D004075:Diglycerides; D007527:Isoenzymes; D011493:Protein Kinase C