Parameters affecting the results in a program of artificial insemination with donor sperm. A 12-year retrospective review of more than 1800 cycles.
OBJECTIVE
We aimed to establish the influence of the parameters affecting artificial insemination (AI) results in order to describe the ideal situations to achieve the best results as well as to adequately counsel the patients undergoing these treatments about their pregnancy chances.


METHODS
We performed a controlled retrospective clinical study over more than one decade in a total of 1858 cycles in 710 patients. Clinical histories and computer registers were systematically reviewed between January 1990 and June 2002. We analyzed the influence of diverse factors affecting AI results such as patient's age, ovarian stimulation, and seminal characteristics to offer a detailed description of the technique.


RESULTS
Less than 35-years-old, smooth ovarian stimulation and 5 million of progressive motile sperm inseminated two consecutive days are the optimum conditions for achieving good results. Also, period of time that sperm remained frozen do not affect the result. Furthermore, we present the likely or expected outcomes of these treatments depending on the male and female etiologies.


CONCLUSIONS
We discourage AI in aged patients, and strongly recommend undergoing ovarian stimulation. Nonetheless, we must reach an adequate amount of sperm with good motility in order to inseminate with maximum guaranties of success.
Instituto Valenciano de Infertilidad, Spain. zuzu@ivi.es
J L
JL
Zuzuarregui
M
M
Meseguer
N
N
Garrido
C
C
Simón
A
A
Pellicer
J
J
Remohí
D000367:Age Factors; D015925:Cryopreservation / Q000592:standards; D005260:Female; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000379:methods* / Q000592:standards; D008297:Male; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012662:Semen Preservation; D013081:Sperm Motility / Q000502:physiology; D014019:Tissue Donors; D016896:Treatment Outcome