[The effect of intraperitoneal heparin on distribution of ACC-M in lung and liver].
OBJECTIVE
To investigate the effect of intraperitoneal heparin on the adhesion of highly lung metastasic adenoid cystic carcinoma cell line (ACC-M) in lung.


METHODS
3HTdR labeled ACC-M cells were injected by intravenous infusion after intraperitoneal injection with 200 units heparin. 4 mice of each group were killed at 2 h, 6 h and 18 h after infusion. The relative radioactivity (CPM) in lung and liver was detected.


RESULTS
3H-activity per gram in lung of heparin group was lower than control at the same time. There was significant difference between the two groups (P < 0.001). There was no difference between the two groups in liver (P > 0.05).


CONCLUSIONS
The results of this study suggest that the highly lung metastasis characteristic of ACC-M may be partially inhabited by the use of intraperitoneal heparin.
Wang
Xin-jun
XJ
Dept. of Oral and Maxillofacial Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China.
Chen
Wan-tao
WT
Zhou
Zheng-yan
ZY
Ma
Yan-qing
YQ
Zhou
Xiao-jian
XJ
D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D002448:Cell Adhesion / Q000187:drug effects*; D045744:Cell Line, Tumor; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011897:Random Allocation; D012468:Salivary Gland Neoplasms / Q000473:pathology*
D006493:Heparin