Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in patients with chronic active EBV infection.
To clarify the pathogenesis of chronic active Epstein-Barr virus (EBV) infection, EBV-specific CD8+ T cells were enumerated, by use of human leukocyte antigen (HLA)-A*2402-restricted tetramers, in 8 patients with chronic active EBV infection, 10 patients with infectious mononucleosis, and 16 EBV-seropositive healthy control subjects. In most of the patients with chronic active EBV infection, EBV-specific CD8+ T cells were not detected. Of note, latent membrane protein 2-specific CD8+ T cells were not detectable in any patients with chronic active EBV infection. In contrast, EBV-specific CD8+ T cells were detected in patients with infectious mononucleosis and in healthy control subjects. Low frequencies of EBV-specific CD8+ T cells may be one of the immunological features of chronic active EBV infection.
Department of Pediatrics, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Japan.
Naomi
N
Sugaya
Hiroshi
H
Kimura
Shinya
S
Hara
Yo
Y
Hoshino
Seiji
S
Kojima
Tsuneo
T
Morishima
Tatsuya
T
Tsurumi
Kiyotaka
K
Kuzushima
D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D002908:Chronic Disease; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000821:virology; D015234:HLA-A Antigens / Q000737:chemistry / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology* / Q000821:virology; D008213:Lymphocyte Activation
D015234:HLA-A Antigens