Cost-effectiveness of nevirapine to prevent mother-to-child HIV transmission in eight African countries.
BACKGROUND
A comprehensive approach to preventing HIV infection in infants has been recommended, including: (a) preventing HIV in young women, (b) reducing unintended pregnancies among HIV-infected women, (c) preventing vertical transmission (PMTCT), and (d) providing care, treatment, and support to HIV-infected women and their families. Most attention has been given to preventing vertical transmission based on analysis showing nevirapine to be inexpensive and cost-effective.


METHODS
The following were determined using data from eight African countries: national program costs and impact on infant infections; reductions in adult HIV prevalence and unintended pregnancies among HIV-infected women that would have equivalent impact on infant HIV infections averted as the nevirapine intervention; and the cost threshold for drugs with greater efficacy than nevirapine yielding an equivalent cost per DALY saved.


RESULTS
Average national annual program cost was 4.8 million dollars. There was, per country, an average of 1898 averted infant HIV infections (2517 US dollars per HIV infection and 84 US dollars per DALY averted). Lowering HIV prevalence among women by 1.25% or reducing unintended pregnancy among HIV-infected women by 16% yielded an equivalent reduction in infant cases. An antiretroviral drug with 70% efficacy could cost 152 US dollars and have the same cost per DALY averted as nevirapine at 47% efficacy.


CONCLUSIONS
Cost-effectiveness of nevirapine prophylaxis is influenced by health system costs, low client uptake, and poor effectiveness of nevirapine. Small reductions in maternal HIV prevalence or unintended pregnancy by HIV-infected women have equivalent impacts on infant HIV incidence and should be part of an overall strategy to lessen numbers of infant infections.
Sweat
Michael D
MD
Department of International Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA.
O'Reilly
Kevin R
KR
Schmid
George P
GP
Denison
Julie
J
de Zoysa
Isabelle
I
D000328:Adult; D019380:Anti-HIV Agents / Q000191:economics / Q000627:therapeutic use*; D001902:Botswana / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D007560:Cote d'Ivoire / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000191:economics / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000191:economics / Q000517:prevention & control*; D007630:Kenya / Q000453:epidemiology; D019829:Nevirapine / Q000191:economics / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000191:economics / Q000517:prevention & control; D015995:Prevalence; D012432:Rwanda / Q000453:epidemiology; D013636:Tanzania / Q000453:epidemiology; D014454:Uganda / Q000453:epidemiology; D015024:Zambia / Q000453:epidemiology; D015030:Zimbabwe / Q000453:epidemiology
D019380:Anti-HIV Agents; D019829:Nevirapine