[Expression of proliferating cell nuclear antigen/bcl-2 in gray gingival tissue].
OBJECTIVE
To study the expression of PCNA/bcl-2 protein in gray and normal gingival tissue, and to investigate the biological effect of procelain-fused-to-metals (PFM).


METHODS
Gray gingival tissue animal model was established by PFM prosthesis and immunohistochemistry S-P method was used to detect the PCNA/bcl-2 protein expression in gingival tissue after 3 months, 6 months in PFM groups and control group.


RESULTS
The expression of PCNA had significant difference between the 3th month group and the control group (P < 0.05); no significant difference was found between the 6th month group and the control group (P > 0.05). The expression of bcl-2 had no significant difference between the 6th month group and the control group (P > 0.05).


CONCLUSIONS
There were a correlation between the expression of PCNA and inflammation of the gray gingival tissue; The expression of PCNA and bcl-2 protein does not indicate that gray gingival tissue had dysplasia change.
Chen
Lin
L
Dept. of Prosthodontics, Stomatological Hospital of Zunyi Medical College, Zunyi 563003, China.
Zhu
Guo-wei
GW
Yang
Xiao-hong
XH
Liu
Hua-qing
HQ
D000818:Animals; D003442:Crowns; D005881:Gingiva / Q000378:metabolism* / Q000473:pathology; D016876:Metal Ceramic Alloys; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D011817:Rabbits
D016876:Metal Ceramic Alloys; D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2