Homologous recombination-mediated double-strand break repair.
Exchange of DNA strands between homologous DNA molecules via recombination ensures accurate genome duplication and preservation of genome integrity. Biochemical studies have provided insights into the molecular mechanisms by which homologous recombination proteins perform these essential tasks. More recent cell biological experiments are addressing the behavior of homologous recombination proteins in cells. The challenge ahead is to uncover the relationship between the individual biochemical activities of homologous recombination proteins and their coordinated action in the context of the living cell.
Wyman
Claire
C
Department of Cell Biology & Genetics, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands. c.wyman@erasmusmc.nl
Ristic
Dejan
D
Kanaar
Roland
R
D000818:Animals; D004247:DNA / Q000235:genetics; D004249:DNA Damage; D004260:DNA Repair; D045566:DNA, Cruciform; D004926:Escherichia coli / Q000235:genetics; D016678:Genome; D006801:Humans; D011995:Recombination, Genetic
D045566:DNA, Cruciform; D004247:DNA