[Significance of current bio- and molecular-markers in urological cancers].
In order to reconfirm their diagnostic and predictive significance, bio- and molecular-markers of urological cancers (prostate, urothelial, kidney, and testicular cancer) are reviewed. In prostate cancer, although prostatic specific antigen (PSA) is a gold standard marker for its screening and monitoring, recent studies have revealed that PSA-related markers have additional information for patients with a gray zone PSA score. Prostate-specific membrane antigen (PSMA) may provide new applications for detection of high-grade cancer or microscopic circulating prostate cancer cells in the blood. In urothelial cancers, several urinary markers are available and may be helpful in the diagnosis of lower-grade urothelial cancers, which have a low sensitivity of urinary cytology. In testicular cancer, lactate dehydrogenase (LDH), alpha-fetoprotein (AFP), and human chorionic gonadotropin (hCG) are essential markers not only to determine the tumor stage but also the prognosis of the patient. In renal cell carcinoma (RCC), unfortunately, no definitive biomarker is available for its diagnosis and monitoring. Thus, we must find new specific bio- and molecular-markers that reflect the biological activity of RCC.
Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.
Toru
T
Shimazui
Hideyuki
H
Akaza
D000954:Antigens, Surface / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood; D043425:Glutamate Carboxypeptidase II / Q000097:blood; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D019859:Proto-Oncogene Proteins c-met / Q000097:blood; D013736:Testicular Neoplasms / Q000175:diagnosis; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*; D014571:Urologic Neoplasms / Q000175:diagnosis*; D000509:alpha-Fetoproteins / Q000032:analysis
D000954:Antigens, Surface; D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D009363:Neoplasm Proteins; D000509:alpha-Fetoproteins; C030193:immunosuppressive acidic protein; D007770:L-Lactate Dehydrogenase; D019859:Proto-Oncogene Proteins c-met; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II; D017430:Prostate-Specific Antigen