8-Hydroxydaidzein, an aldose reductase inhibitor from okara fermented with Aspergillus sp. HK-388.
The aldose reductase (AR) inhibitor, 8-hydroxydaidzein, was isolated and identified from a methanolic extract of okara (soybean pulp) fermented with the fungal strain, Aspergillus sp. HK-388. 8-Hydroxydaidzein showed non-competitive inhibition of human recombinant AR with respect to DL-glyceraldehyde, its Ki value being evaluated as 7.0 microM.
Fujita
Tomoyuki
T
Division of Applied Biological Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan. fujita@biochem.osakafu-u.ac.jp
Funako
Tomoyoshi
T
Hayashi
Hideo
H
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D001230:Aspergillus / Q000201:enzymology*; D005985:Glyceraldehyde / Q000378:metabolism; D006801:Humans; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012988:Soil Microbiology; D013025:Glycine max / Q000737:chemistry
C498104:8-hydroxydaidzein; D007529:Isoflavones; D005985:Glyceraldehyde; D000449:Aldehyde Reductase