Insulinogenic index at 15 min as a marker of stable eating behavior in bulimia nervosa.
OBJECTIVE
The aim of this study was to determine the relationship between insulinogenic index at 15 min (II15 min), body weight maintenance, and the presence of vomiting in patients with bulimia nervosa.


METHODS
Forty-eight bulimic inpatients and 14 controls underwent an oral glucose tolerance test on the seventh hospital day. We calculated II15 min and other biological markers, including serum amylase concentrations. During the first week after admission, we monitored the frequency of vomiting and calculated changes in body weight. Patients were divided into 4 subgroups according to the presence of vomiting and weight loss.


RESULTS
Two-factor analysis of variance of the II15 min value revealed significant main effects of vomiting and body weight change (P < 0.001 for both). The II15 min values for controls and bulimic patients with weight loss and no vomiting were lower than those of other bulimic groups. The II15 min values were positively correlated with serum amylase concentrations (r = 0.37, P < 0.01), body weight change (r = 0.35, P < 0.05), and frequencies of vomiting (r = 0.49, P < 0.05).


CONCLUSIONS
These findings suggest that II15 min values may be a useful marker for assessing the stability of eating behavior in patients with bulimia nervosa.
Division of Behavioral Medicine, Department of Social and Behavioral Medicine, Course for Health Science, Kagoshima University Graduate School of Medicine and Dental Science, 8-35-1 Sakuragaoka, Kagoshima-City 890-8520, Japan.
Daisuke
D
Yasuhara
Yoshiki
Y
Tatebe
Takashi
T
Nakayama
Tetsuro
T
Muranaga
Shin-Ichi
S
Nozoe
Tetsuro
T
Naruo
D000328:Adult; D000681:Amylases / Q000097:blood; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000502:physiology*; D002032:Bulimia / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D005163:Factor Analysis, Statistical; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D014839:Vomiting / Q000097:blood / Q000503:physiopathology*
D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D000681:Amylases