Store-operated calcium channels: how do we measure them, and why do we care?
A major mechanism whereby calcium entry into cells is regulated is the store-operated or capacitative calcium entry pathway. In this article, two basic issues are discussed: (i) the methods investigators use to measure store-operated entry, and (ii) the role played by the store-operated pathway in responses to hormones and neurotransmitters under physiological conditions. The two topics are considered together because they are closely interrelated; as we begin to ask questions about calcium movements at low concentrations of agonists, the technology to measure these movements becomes increasing challenging.
Putney
James W
JW
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Post Office Box 12233, Research Triangle Park, NC 27709, USA. putney@niehs.nih.gov
D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D018408:Patch-Clamp Techniques / Q000379:methods*
D015220:Calcium Channels