Linkage mapping of the locus responsible for male pseudohermaphroditism (mp) on rat chromosome 7.
TF is a mutant rat strain showing male pseudohermaphroditism controlled by an autosomal single recessive gene (mp). The affected rats show lack of Leydig cells and androgen deficiency. In this study, we performed linkage analysis using F(2) progeny of crosses between TF and BN strains to determine the chromosomal localization of the mp locus. The mp locus was mapped in a 4 cM region of the distal region of rat chromosome 7 between D7Rat3 and D7Rat115 or D7Rat94. Comparison of the linkage map with corresponding regions of the published rat genome sequence revealed several candidate genes for the mp mutation, including the Dhh, Tegt, Gdp3, and Amhr2 genes.
Graduate School of Natural Science and Technology, Okayama University, Japan.
Yasuhiro
Y
Kawai
Yuriko
Y
Takeno
Eiji
E
Kobayashi
Motokazu
M
Tachibana
Yasumasa
Y
Wakafuji
Junko
J
Noguchi
Tetsuo
T
Kunieda
D000818:Animals; D002874:Chromosome Mapping; D012734:Disorders of Sex Development / Q000235:genetics*; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains