LD1 amplifications in Leishmania.
The genome of Leishmania is quite plastic. Chromosomal rearrangements and DNA amplifications are common events in all the species of the genus. Gene amplification occurs both as a mechanism of drug resistance and in the absence of drug pressure. The best known spontaneous amplification in Leishmania is the so-called LD1 family of amplicons. In the past few years there have been great advances in our knowledge of LD1 elements; here, Manuel Segovia and Ginés Ortiz review all the available data.
Segovia
M
M
Departamento de Genética y Microbiología, Facultad de Medicina, Universidad de Murcia, Spain. msegovia@fcu.um.es
Ortiz
G
G