Effect of pH on the production of the antitumor antibiotic retamycin by Streptomyces olindensis.
The effect of pH on cell growth and retamycin production in batch bioreactor cultures of Streptomyces olindensis ICB20 was investigated. In fermentations pH-controlled over the range 6.0-8.0, the highest retamycin production was achieved at pH 7.0, and the maximum concentration of retamycin, about 1.36 A (absorbance) units, was about 43, 58 and 232% higher than the values obtained at pH 7.5, 6.0 and 8.0 respectively.
Guimarães
Luciana M
LM
Departamento de Engenharia Química, Escola Politécnica da Universidade de São Paulo, P.O. Box 61548, CEP 05424-970, São Paulo, SP, Brazil.
Furlan
Renata L de Araújo
RL
Garrido
Leandro M
LM
Ventura
Armando
A
Padilla
Gabriel
G
Facciotti
Maria Cândida R
MC
D018943:Anthracyclines / Q000378:metabolism*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D019149:Bioreactors / Q000382:microbiology*; D018929:Cell Culture Techniques / Q000379:methods*; D049109:Cell Proliferation; D006863:Hydrogen-Ion Concentration; D013302:Streptomyces / Q000737:chemistry / Q000254:growth & development* / Q000378:metabolism*
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C002920:retamycin