Obsessive-compulsive symptoms in parents of Tourette syndrome probands and autism spectrum disorder probands.
Obsessive-compulsive symptoms (OCS) frequently occur in patients with Tourette syndrome (TS) and autism spectrum disorders (ASD). It has been suggested that genetic factors play a role in the transmission of both TS and ASD and that obsessive-compulsive disorder (OCD) may have some genetic relationship with these disorders. The objective of this study was to explore whether the OCS associated with TS and ASD were found in the parents of TS and ASD probands by comparing them with normal controls. The subjects were parents of 13 TS and 16 ASD probands. All parents underwent an examination for tic symptoms and OCD, and completed the Maudsley Obsessional Compulsive Inventory (MOCI) and State-Trait Anxiety Inventory (STAI). No significant differences were observed in the MOCI and STAI scores among all three groups. However, the MOCI total score was higher in fathers of ASD probands than in male normal controls with a marginal significance. There was a significant tendency for the mean cleaning score of MOCI in fathers of ASD probands to be higher than that in male normal controls, and the mean checking score in fathers of ASD probands was fourfold higher than that in male normal controls, although there was no significant difference. No significant relationship was observed between OCS in TS or ASD probands and OCS of their parents. Further studies on OCD and OCS including a dimensional approach within ASD families are needed.
Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan. yukiko-k@kitasato-u.ac.jp
Yukiko
Y
Kano
Masataka
M
Ohta
Yoko
Y
Nagai
David L
DL
Pauls
James F
JF
Leckman
D000328:Adult; D001321:Autistic Disorder / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000235:genetics*; D010290:Parents / Q000523:psychology*; D010555:Personality Inventory / Q000706:statistics & numerical data; D010641:Phenotype; D011594:Psychometrics; D012306:Risk; D012737:Sex Factors; D005879:Tourette Syndrome / Q000175:diagnosis / Q000235:genetics*