Virus subversion of protective immunity.
The major histocompatibility (MHC) class I antigen presentation pathway plays a pivotal role in immunity to viruses. MHC class I molecules are expressed on the cell surface of all nucleated cells and present peptides derived from intracellular proteins to cytotoxic T lymphocytes (CTLs), which then eliminate virally infected cells. However, many viruses have evolved proteins to inhibit the MHC class I pathway, thus enabling virally infected cells to escape CTL lysis. In this review, we summarize recent findings about viral inhibition of the MHC class I pathway.
School of Biochemistry and Microbiology, University of Leeds, Leeds, LS2 9JT, UK. e.w.hewitt@leeds.ac.uk
Eric W
EW
Hewitt
Gillian E
GE
Dugan
D003587:Cytomegalovirus / Q000276:immunology; D015497:HIV-1 / Q000276:immunology; D016174:Hepacivirus / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*; D027383:Papillomaviridae / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014780:Viruses / Q000276:immunology*