An expanding appreciation of the role chemokine receptors play in cancer progression.
The contribution of small molecular weight chemoattractant cytokines (chemokines) and their receptors in the trafficking of tumor, immune and vascular cells pertaining to the development and progression of cancer has begun to be investigated. The current literature indicates that interactions between the immune network, angiogenic and cell survival cascades are important for the trafficking and progression of human cancer and that chemokines and chemokine receptors play a central role in these complex inter-related pathways. Several therapeutic approaches have been reviewed and suggest that the most promising arise from the development of combinations of chemokine receptor antagonists.
National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, NCI-Frederick, Frederick, MD 21702, USA. howardz@mail.ncifcrf.gov
O M Zack
OM
Howard
Carole L
CL
Galligan
D002470:Cell Survival; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D008024:Ligands; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D010455:Peptides / Q000627:therapeutic use; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000502:physiology*
D018925:Chemokines; D008024:Ligands; D010455:Peptides; D019707:Receptors, Chemokine