Chiral resolution of some piperidine 2, 6-dione drugs by high performance liquid chromatography on Kromasil CHI-DMB column.
Kromasil CHI-DMB chiral stationary phase (CSP) is used to resolve some piperidine-2, 6-diones under normal mobile phase mode. Base-line separation was achieved using hexane and dioxane (90 : 10 v/v) for aminoglutethimide (AG), pyridoglutethimide (PG), cyclohexylaminoglutethimide (ChAG), thioglutethimide (TG), and N-acetyl aminoglutethimide (AAG). The chromatographic parameters are reported. The chiral recognition mechanisms between the analytes and the CSP depend primarily on hydrogen bonding and/or (pi-pi) interactions.
Aboul-Enein
Hassan Y
HY
Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Saudi Arabia. enein@kfshrc.edu.sa
D002851:Chromatography, High Pressure Liquid; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D010881:Piperidones / Q000737:chemistry* / Q000302:isolation & purification; D012997:Solvents; D013237:Stereoisomerism
D007202:Indicators and Reagents; D010881:Piperidones; D012997:Solvents