Medical and surgical outcome of tricuspid regurgitation caused by flail leaflets.
OBJECTIVE
We sought to evaluate the medical and surgical outcome of tricuspid regurgitation caused by flail leaflets.


METHODS
We analyzed the cause, clinical presentation, outcome, and natural history of 60 patients with tricuspid regurgitation caused by flail leaflets, a cause of mostly severe and organic tricuspid regurgitation, diagnosed by means of echocardiography between 1980 and 2000.


RESULTS
The main cause was traumatic (62%). Clinical presentation was often severe: 57% were symptomatic, 33% had a history of congestive heart failure, and 40% had a history of atrial fibrillation. Compared with expected survival of the US matched population, excess mortality (39% +/- 10% at 10 years or 4.5% yearly, P <.01) was observed. Even patients asymptomatic at presentation experienced high tricuspid-related event rates (at 10 years, 75% +/- 15% had symptoms or heart failure, atrial fibrillation, surgical intervention, or death). In those patients severe enlargement of right-sided chambers was predictive of poor outcome (at 5 years: 86% +/- 9% vs 39% +/- 11%, P <.01) independent of cause (P =.31). The poor medical outcome was further confirmed by high event rates (69% +/- 9% at 15 years) in the natural history beginning from the flail's occurrence. Tricuspid operations were performed in 33 patients (55% +/- 7% at 5 years), with valve repair in 82%, low mortality (3%), and, despite frequently refractory atrial fibrillation, symptomatic improvement in 88%.


CONCLUSIONS
Tricuspid regurgitation caused by flail leaflets is a serious disease associated with excess mortality and high morbidity. Tricuspid valve repair can often be performed with low risk, allowing symptomatic improvement. These results suggest that surgical intervention should be considered early in the course of the disease before the occurrence of irreversible consequences.
Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.
David
D
Messika-Zeitoun
Helen
H
Thomson
Michael
M
Bellamy
Christopher
C
Scott
Christophe
C
Tribouilloy
Joseph
J
Dearani
A Jamil
AJ
Tajik
Hartzell
H
Schaff
Maurice
M
Enriquez-Sarano
D005260:Female; D006349:Heart Valve Diseases / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome; D014261:Tricuspid Valve; D014262:Tricuspid Valve Insufficiency / Q000209:etiology* / Q000401:mortality / Q000601:surgery*