Mixed connective tissue disease with interstitial pneumonia in HTLV-1 carrier: case report and review of the literature.
We report on a carrier of human T-lymphotropic virus type 1 (HTLV-1) who developed mixed connective tissue disease (MCTD). This patient suddenly manifested clinical symptoms and interstitial pneumonia ascribable to MCTD following long-term infection with HTLV-1. After initiation of oral prednisolone all manifestations quickly improved in parallel with a decrease in inflammatory reactions. In this patient HTLV-1 infection might have played an important role in the pathogenesis of MCTD. Since HTLV-1 can cause adult T-cell leukemia and HTLV-1-associated myelopathy, and also collagen diseases including MCTD, careful observation is necessary even in a carrier, particularly when autoantibodies are detectable in serum.
Division of Rheumatology, Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621 Matsumoto, Japan.
Yasuhiro
Y
Shimojima
Wataru
W
Ishii
Akiyo
A
Hineno
Kanji
K
Yamamoto
Masayuki
M
Matsuda
Shu-ichi
S
Ikeda
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002353:Carrier State / Q000276:immunology; D005260:Female; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D008947:Mixed Connective Tissue Disease / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D011239:Prednisolone