Presence of luteinizing hormone/human chorionic gonadotropin receptors in male breast tissues.
Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders.
Department of Medicine, Stony Brook University, Stony Brook, New York 11794-8154, USA. hcarlson@notes.cc.sunysb.edu
Harold E
HE
Carlson
Philip
P
Kane
Z M
ZM
Lei
X
X
Li
C V
CV
Rao
D000328:Adult; D000368:Aged; D001940:Breast / Q000378:metabolism*; D018567:Breast Neoplasms, Male / Q000378:metabolism*; D016022:Case-Control Studies; D006177:Gynecomastia / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D011974:Receptors, LH / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D011974:Receptors, LH