[Animal test of nHA-PA66 used in root canal filling].
OBJECTIVE
To assess the dogs' tissue reaction to nHA-PA66 which is prepared to be used as a new root canal filling sealer.


METHODS
The experimental apical periodontitis of dogs was induced first, then nHA-PA66 was used in the test groups while CCQ was used in the control group. The reactions of periapical tissues were measured by histological means.


RESULTS
One month after nHA-PA66 was used in root canal filling, the dogs' periapical tissues showed mild to moderate inflammatory reactions, the X-ray films showed decreased radiolucent area as compared with the previous film. Three months later, tissue repairs occurred, which exhibited even more decreased radiolucent area on X-ray films. nHA-PA66 caused weak inflammatory reaction while the reparative reaction happened early.


CONCLUSIONS
nHA-PA66 has good tissue compatibility and is a potential sealer for root filling in clinical use.
West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Ling
L
Ye
Qin
Q
Su
Xue-dong
XD
Zhou
Hong
H
Tan
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D004285:Dogs; D036103:Nanotechnology; D009757:Nylons / Q000633:toxicity; D010485:Periapical Periodontitis / Q000139:chemically induced; D010486:Periapical Tissue / Q000187:drug effects*; D012387:Root Canal Filling Materials / Q000633:toxicity*; D012390:Root Canal Therapy / Q000379:methods
D001672:Biocompatible Materials; D009757:Nylons; D012387:Root Canal Filling Materials