Antimicrobial activities of diterpene dialdehydes, constituents from myoga (Zingiber mioga Roscoe), and their quantitative analysis.
The antimicrobial activities of the three diterpene dialdehydes, miogadial, galanal A and galanal B, isolated from flower buds of the myoga (Zingiber mioga Roscoe) plant were investigated with some strains of bacteria, yeasts and molds. Among the three compounds, miogadial exhibited relatively greater antimicrobial activity than the others against Gram-positive bacteria and yeasts. Galanals A and B also behaved as antimicrobial agents against Gram-positive bacteria and yeasts. The content of miogadial in the flower buds was much higher than that in the leaves, whereas galanals A and B were contained at high levels in the leaves and rhizomes.
Department of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki 370-0033, Japan.
Masako
M
Abe
Yoshio
Y
Ozawa
Yasushi
Y
Uda
Fuminori
F
Yamada
Yasujiro
Y
Morimitsu
Yoshimasa
Y
Nakamura
Toshihiko
T
Osawa
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D035264:Flowers / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D030521:Zingiberaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts; C476263:miogadial; C476264:galanal A; C476265:galanal B