Suppressor T cells in human diseases.
Although central and peripheral tolerance are important for the regulation of human immune responses to self- and microbial antigens, an important role of suppressor CD4(+) CD25(+) T cells is suggested from the recent investigations of human autoimmune diseases and HIV. These new data provide increasing evidence that altered function of CD4(+) CD25(+) T cells may be an important factor in a wide range of human inflammatory and infectious diseases.
Harvard Medical School, 77 Ave. Louis Pasteur, Boston, MA 02115, USA. callan@rics.bwh.harvard.edu
Clare
C
Baecher-Allan
David A
DA
Hafler
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015704:CD4 Antigens / Q000032:analysis*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D015704:CD4 Antigens; D015375:Receptors, Interleukin-2