Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques.
Some monocytes normally take up residence in tissues as sessile macrophages, but others differentiate into migratory cells resembling dendritic cells that emigrate to lymph nodes. In an in vitro model of a vessel wall, lipid mediators lysophosphatidic acid and platelet-activating factor, whose signals are implicated in promoting atherosclerosis, blocked conversion of monocytes into migratory cells and favored their retention in the subendothelium. In vivo studies revealed trafficking of monocyte-derived cells from atherosclerotic plaques during lesion regression, but little emigration was detected from progressive plaques. Thus, progression of atherosclerotic plaques may result not only from robust monocyte recruitment into arterial walls but also from reduced emigration of these cells from lesions.
Llodrá
Jaime
J
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Angeli
Véronique
V
Liu
Jianhua
J
Trogan
Eugene
E
Fisher
Edward A
EA
Randolph
Gwendalyn J
GJ
D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology / Q000637:transplantation; D001057:Apolipoproteins E / Q000235:genetics; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology*; D002465:Cell Movement; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D007700:Kinetics; D008055:Lipids / Q000494:pharmacology; D008246:Lysophospholipids / Q000494:pharmacology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009000:Monocytes / Q000473:pathology* / Q000502:physiology; D010972:Platelet Activating Factor / Q000494:pharmacology; D014184:Transplantation, Homologous
D001057:Apolipoproteins E; D008055:Lipids; D008246:Lysophospholipids; D010972:Platelet Activating Factor; C032881:lysophosphatidic acid