The antioxidative effect of the bacteria Dienococcus radiophilus against LDL lipid peroxidation.
BACKGROUND
Lipid peroxidation is an important process in the development of atherosclerosis. Thus agents with antioxidant properties may play an important role in the inhibition of atherosclerosis.


OBJECTIVE
In this study we aimed to show that the lipid extract of the bacteria Deinococcus radiophilus (leDR) has antioxidant properties against LDL oxidation.


RESULTS
This antioxidant effect was shown in both transition metal ion and free radical generating systems. We also showed that leDR can protect LDL from UV light-induced oxidative damage. The antioxidative capacity of leDR is partly due to copper ion chelation.


CONCLUSIONS
We conclude that some specific bacteria constituent has the ability to inhibit LDL oxidation and, thus, to attenuate atherogenesis.
The Lipid Research Laboratory, Technion Faculty of Medicine The Rappaport Family Institute for Research in the Medical Sciences, and Gastroenterology Bnai Zion Medical Center, Haifa, Israel. lavya@netvision.net.il
A
A
Lavy
Y
Y
Neeman
B
B
Fuhrman
D050197:Atherosclerosis / Q000517:prevention & control*; D002614:Chelating Agents / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers; D005609:Free Radicals; D006094:Gram-Positive Bacteria / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008077:Lipoproteins, LDL / Q000097:blood; D010084:Oxidation-Reduction; D014466:Ultraviolet Rays / Q000009:adverse effects*
D002614:Chelating Agents; D016166:Free Radical Scavengers; D005609:Free Radicals; D008077:Lipoproteins, LDL; D003300:Copper