Hepatitis after sevoflurane exposure in an infant suffering from primary hyperoxaluria type 1.
An 11-mo-old child with primary hyperoxaluria was scheduled for a nephroureteromia procedure. Anesthesia was induced and maintained with sevoflurane. Two days after the operation, a hepatomegaly was diagnosed, and a considerable increase in liver enzymes was observed. These pathologic findings disappeared without treatment within 7 days. In a subsequent operation 2 wk later, general anesthesia was performed (sevoflurane was avoided). After the second operation, no pathologic findings could be detected. Nothing in this patient's disease or the conduct of the anesthesia suggested a cause for the injury other than an idiosyncratic response to sevoflurane.
Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Münster, Albert Schweitzer-Strasse 33, D-48129 Münster, Germany. reich@anit.uni-muenster.de
Alexander
A
Reich
Anne Schulze
AS
Everding
Monika
M
Bulla
Olaf Anselm
OA
Brinkmann
Hugo
H
Van Aken
D000768:Anesthesia, General / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D015415:Biomarkers; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D006529:Hepatomegaly / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000150:complications*; D007223:Infant; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D015415:Biomarkers; D008738:Methyl Ethers; D000077149:Sevoflurane