Amides from Streptomyces hygroscopicus and their antimicrobial activity [corrected].
Three amides, N-salicyloyl-2-aminopropan-1,3-diol (1) and 1-acetyl-N-salicyloyl-2-aminopropan-3-ol (2) including a natural product, N-salicyloyl-2-aminopropan-1-ol (3) were isolated from an ethyl acetate extract of the culture filtrate of Streptomyces hygroscopicus [corrected] The structures of these compounds were unambiguously established by interpretation of their spectral data including, a series of 1D and 2D-NMR and MS analyses. Compounds 1-3 showed significant antibacterial activity against a wide range of Gram positive and Gram negative bacteria.
Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
M Shamim
MS
Hossain
M Aslam
MA
Hossain
M Mukhlesur
MM
Rahman
M A Mojid
MA
Mondol
M S A
MS
Bhuiyan
Alexander I
AI
Gray
Maria E
ME
Flores
Mohammad A
MA
Rashid
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009904:Optical Rotation; D013302:Streptomyces / Q000737:chemistry*
D000577:Amides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents