Late-onset depression with mild cognitive deficits: electrophysiological evidences for a preclinical dementia syndrome.
Mild cognitive impairment (MCI) is present in up to 60% of patients with late-onset depression and constitutes a major diagnostic problem in geriatric psychiatry. Searching for sensitive markers for the detection of early brain changes suggestive of dementia, we compared this depressive risk population with mildly to moderately demented patients and cognitively unimpaired depressed patients using EEG power and coherence. We found a considerable similarity between Alzheimer's disease patients and cognitively impaired depressed patients regarding the cognitive profile and EEG pattern. Changes in EEG power and coherence at frontotemporal leads in depressive patients with MCI thereby allowed discrimination from cognitively unimpaired patients with a sensitivity of 88% and a specifity of 81%.
NeuroImage Nord, Department of Psychiatry, University of Hamburg, Hamburg, Germany. sbrassen@uke.uni-hamburg.de
Stefanie
S
Brassen
Dieter F
DF
Braus
Wolfgang
W
Weber-Fahr
Heike
H
Tost
Steffen
S
Moritz
Georg
G
Adler
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D004562:Electrocardiography; D004569:Electroencephalography; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D015995:Prevalence; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed