[Study on morphological change in intestinal mucosa from injury to repair after hemorrhagic shock].
OBJECTIVE
To study on morphological changes in mucosa of the small and large intestine mucosa after resuscitation of hemorrhagic shock.


METHODS
The morphological changes in intestinal mucosa were observed under light and electron microscope, including the histology of intestinal mucosa, determination of height of villi and evaluation of mucosa damage index in the different phases after traumatic-hemorrhagic shock.


RESULTS
Mucosa epithelial injury was obvious in small intestine were even at 0 hour, becoming more serious in 1 hour up to 3 hours. The tissue repair began after 3 hours, though the injury was still serious. Most of the inJured mucosa began to repair after 6 hours, and completed in 24 hours. The condition of the large intestine was similar to that of the small intestine, but the injury was less severe. The mucosal thickness and the height of villi were diminished after 1 hour of shock, but there was no obvious change in the colon.


CONCLUSIONS
In the early phase after hemorrhagic shock, intestinal mucosal barrier are subJected to damage, but it could repair and recover in a short time. Compare with small intestine, large intestine have stronger potentiality against injury.
Chang
Jian-xing
JX
The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, China.
Chen
Shuang
S
Fu
Yu-ru
YR
Chang
Rui-ming
RM
Chen
Jian-wen
JW
Huang
Zi-tong
ZT
D000818:Animals; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000098:blood supply / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology*; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000473:pathology* / Q000628:therapy