Role of cytomegalovirus, Epstein-Barr virus, and human herpes virus-8 in benign lymphoepithelial cysts of the parotid gland.
OBJECTIVE
To provide background and evaluate the role of herpesviruses in benign lymphoepithelial cysts (BLC) of the parotid gland.


METHODS
Case series derived from review of pathology specimens.


METHODS
Radiolabeled polymerase chain reaction (PCR) analysis was used to detect for the presence of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpes virus 8 (HHV-8) DNA sequences in 14 paraffin embedded specimens and 1 freshly aspirated BLC specimen. Thirteen normal parotid tissue specimens obtained from paraffin embedded blocks were used as a control group.


RESULTS
CMV was detected with nearly equal frequency between the two groups (23% of normal vs. 20% in BLC). HHV-8 was found in 13% of the BLC group and in none of the normal group (P =.4841). There was significant difference in EBV detection between the normal (0%) and the BLC (33%) groups (P =.0437).


CONCLUSIONS
CMV and HHV-8 does not appear to be associated with BLCs. Although EBV is found more frequently in BLC than in normal parotid controls, further studies are needed to elucidate the role of this virus in BLC pathogenesis.
Yen
Thomas L
TL
Department of Otolaryngology--Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143-0342, USA.
Murr
Andrew H
AH
Rabin
Joseph
J
Mhatre
Anand N
AN
Lalwani
Anil K
AK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003560:Cysts / Q000150:complications / Q000821:virology*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000150:complications / Q000821:virology*; D010306:Parotid Gland / Q000821:virology; D016133:Polymerase Chain Reaction
D004279:DNA, Viral