Russell body gastritis: an unusual, tumor-like lesion of the gastric mucosa.
The case of an 80-year-old woman who presented with epigastric symptoms is reported. Upper gastrointestinal endoscopy displayed Candida esophagitis and a localized swelling of the fundic mucosa. Histologic examination of the gastric biopsy showed a distinctive accumulation of numerous uniform plasma cells filled with so-called Russell bodies. On low-power view, the lesion resembled a neoplastic process due to the marked expansion of the lamina propria with distension of fundic glands. However, immunohistochemistry confirmed a polyclonal pattern of the plasma cells. This unusual reactive lesion of the gastric mucosa has only rarely been described and has been termed Russell body gastritis.
Erbersdobler
Andreas
A
Department of Pathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. erbersdobler@uke.uni-hamburg.de
Petri
Susan
S
Lock
Guntram
G
D000368:Aged; D000369:Aged, 80 and over; D002177:Candidiasis / Q000150:complications; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis; D003937:Diagnosis, Differential; D004941:Esophagitis / Q000150:complications / Q000382:microbiology; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D005756:Gastritis / Q000150:complications / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis; D010950:Plasma Cells / Q000473:pathology*; D013274:Stomach Neoplasms / Q000175:diagnosis