A trial of a new regimen with clomiphene citrate administration to reduce the antiestrogenic effects on reproductive end organs.
OBJECTIVE
To determine the endocrinological and clinical outcomes of a 3-day clomiphene citrate (CC) regimen and compare it with the classical 5-day clomiphene citrate regimen.


METHODS
59 patients, diagnosed with Class II ovulatory deficiency according to the criteria defined by WHO, were randomized into two groups. Patients in Group I received 50mg per day of CC for 3 days starting on the first day of the cycle during 72 cycles. Group II received 50mg per day of CC for 5 days starting on the fifth day during 64 cycles.


RESULTS
The ovulation rate was significantly higher in Group II (78.11%) compared to Group I (63.88%) (P < 0.05). However, the implantation rate was higher in Group I than Group II.


CONCLUSIONS
We observed that starting CC on the first day of the cycle for 3 days would lead to higher implantation rates compared to the classical 5-day CC therapy.
Kelekçi
S
S
Department of Obstetrics and Gynecology, Ankara State Hospital, Ankara, Turkey.
Saygili-Yilmaz
E
E
Inan
I
I
Eminsoy
G
G
D000328:Adult; D000858:Anovulation / Q000150:complications / Q000188:drug therapy; D002996:Clomiphene / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D020847:Estrogen Receptor Modulators / Q000008:administration & dosage*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005836:Genitalia, Female / Q000187:drug effects*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
D020847:Estrogen Receptor Modulators; D005300:Fertility Agents, Female; D002996:Clomiphene