BK virus subtype 1 infection associated with tubulointerstitial nephritis in a renal allograft recipient.
The BK polyomavirus (BKV) infects most of the human population, but clinically relevant infections are usually limited to individuals who are in an immunosuppressed state. The significance of BKV infection was investigated in a 50-year-old man who underwent cadaveric kidney transplantation and was treated with tacrolimus, mycophenolate mofetil and prednisolone. By staining renal biopsy specimens with a monoclonal antibody against BK large T antigen, we were able to observe the relationship between the appearance of the BKV antigen and the extent of immunosuppression in this patient. We also determined that BKV belonged to genotype I by analysis of viral DNA from the patient's urine.
Takayama
Tatsuya
T
Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3912, Japan. takayama@hama-med.ac.jp
Miura
Katsutoshi
K
Han
Guiping
G
Ushiyama
Tomomi
T
Suzuki
Kazuo
K
Fujita
Kimio
K
D001739:BK Virus / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D007564:Japan; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000821:virology*; D027601:Polyomavirus Infections / Q000175:diagnosis*; D014412:Tumor Virus Infections / Q000175:diagnosis*