Effect of sildenafil citrate on penile erection of rhesus macaques.
OBJECTIVE
To examine the effect of sildenafil citrate on penile erection of male rhesus macaque.


METHODS
Twenty Macaca mulatta were divided into the sildenafil treated and the control groups of 10 animals each. The penile size, the corpus cavernosal electromyogram (EMG) and the intra-corpus cavernosal pressure (ICP) were determined.


RESULTS
The diameter of penis and the ICP were significantly increased and the corpus cavernosal EMG significantly reduced in the sildenafil group.


CONCLUSIONS
Sildenafil citrate increases the penile size and ICP and reduces the corpus cavernosal EMG in male rhesus macaque.
Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, Wuhan 430030, China. huangxb@mails.tjmu.edu.cn
Xun-Bin
XB
Huang
Cheng-Liang
CL
Xiong
Cheng-Gao
CG
Yu
Jie-Ling
JL
Zhou
Ji-Yun
JY
Shen
D000818:Animals; D004576:Electromyography; D008253:Macaca mulatta; D008297:Male; D010410:Penile Erection / Q000187:drug effects* / Q000502:physiology; D010413:Penis / Q000033:anatomy & histology / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000494:pharmacology*
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate