Stachyose extract from Rehmannia glutinosa Libosch. to lower plasma glucose in normal and diabetic rats by oral administration.
The hypoglycemic effects of water extract and stachyose extract (Part III) from Rehmannia glutinosa Libosch. were investigated in this paper by oral administration to normal, glucose- and adrenaline-induced hyperglycemic and alloxan-induced diabetic rats. The results showed that Part III had the effect of lowering fasted plasma glucose level and partially preventing hyperglycemia induced by glucose (2.5 g x kg(-1), i.p.) and adrenaline (300 microg x kg(-1), i.p.), respectively, but no obvious dose-dependent effect was found when it was administered at the doses of 100, 200 and 400 mg x kg(-1) for 6 days, i.g. In alloxan-induced diabetic rats, Part III (200 mg x kg(-1) for 15 days, i.g.) gave a significant decrease in blood glucose level. The results suggested that Part III, which is mainly composed of stachyose from Rehmannia glutinosa Libosch., had a significant hypoglycemic effect in glucose- and adrenaline-induced hyperglycemic and alloxan-induced diabetic rats.
Zhang
R X
RX
Department of Pharmacy, Lanzhou General Hospital of PLA, Lanzhou, PR China. Empriqqq@public.lz.gs.cn
Jia
Z P
ZP
Kong
L Y
LY
Ma
H P
HP
Ren
J
J
Li
M X
MX
Ge
X
X
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D004837:Epinephrine; D005260:Female; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D009844:Oligosaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D032267:Rehmannia / Q000737:chemistry*; D014867:Water
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009844:Oligosaccharides; D010936:Plant Extracts; D014867:Water; C005695:stachyose; D004837:Epinephrine