Effect of atorvastatin on the expression of CD40 ligand and P-selectin on platelets in patients with hypercholesterolemia.
The effects of atorvastatin on levels of the CD40 ligand (CD40L or CD154) and P-selectin on platelets were investigated in patients with hypercholesterolemia. The major finding was that short-term atorvastatin treatment (8 weeks) in a group of hypercholesterolemic patients resulted in significant suppression of CD40L and P-selectin expression. Moreover, there was a significant correlation between the magnitude of CD40L downregulation and that of very low-density lipoprotein cholesterol, the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol, and triglycerides. In hypercholesterolemic patients, in addition to its effects on decreasing cholesterol, atorvastatin can intervene in the interaction of CD40-CD40L and the expression of P-selectin on platelets. Thus, interference of CD40-CD40L can be recognized as an integral part of the anti-inflammatory activity of atorvastatin in hypercholesterolemia.
Hwang
Yeo-Shin
YS
Division of Cardiology, Department of Medicine, Kaohsiung Medical University, Taiwan. yshwangr@ms19.hinet.net
Tsai
Wen-Chan
WC
Lu
Ye-Hsu
YH
Lin
Chin-Chen
CC
Chen
Yin-Fu
YF
D000328:Adult; D000069059:Atorvastatin; D015415:Biomarkers / Q000032:analysis; D023201:CD40 Ligand / Q000032:analysis / Q000187:drug effects*; D016022:Case-Control Studies; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D004334:Drug Administration Schedule; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage*; D006801:Humans; D006937:Hypercholesterolemia / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000032:analysis / Q000187:drug effects*; D011336:Probability; D011379:Prognosis; D011758:Pyrroles / Q000008:administration & dosage*; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D015415:Biomarkers; D006538:Heptanoic Acids; D019007:P-Selectin; D011758:Pyrroles; D023201:CD40 Ligand; D000069059:Atorvastatin