Arsenic toxicity in mice and its possible amelioration.
Oral administration of arsenic trioxide (3 and 6 mg/kg body weight/d) for 30 d caused, as compared with vehicle control, dose-dependent significant reductions in body weight, absolute weight, protein, glycogen, as well as, total, dehydro and reduced ascorbic acid contents both in the liver and kidney of arsenic-treated mice. Succinic dehydrogenase (SDH) and phosphorylase only in the liver activities were significantly reduced in a dose-dependent manner. Acid phosphatase activity was significantly decreased in the liver of low dose arsenic-treated animals; however, significant rise in its activity was observed in high dose group. As compared with vehicle control, treatment also caused significant dose-dependent reductions in SDH, alkaline phosphatase and acid phosphatase activities in the kidney of mice. Vitamin E cotreatment as well as, 30 d withdrawal of arsenic trioxide treatment with or without vitamin E caused significant amelioration in arsenic-induced toxicity in mice. Administration of vitamin E during withdrawal of treatment also caused significant amelioration as compared from only withdrawal of the treatment. It is concluded that vitamin E ameliorates arsenic-induced toxicities in the liver and kidney of mice.
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India. ramtejverma2000@yahoo.com
R J
RJ
Verma
Archana
A
Vasu
Abdul Alim
AA
Saiyed
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001151:Arsenic / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D008297:Male; D051379:Mice; D006005:Phosphorylases / Q000494:pharmacology; D013385:Succinate Dehydrogenase / Q000494:pharmacology; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D013385:Succinate Dehydrogenase; D006005:Phosphorylases; D001151:Arsenic