Experience with granulocytapheresis in Crohn's disease.
OBJECTIVE
To describe our experience with granulocyte apheresis to induce remission in patients with active Crohn's disease refractory to conventional treatment. We summarize the results previously obtained with this technique.


CONCLUSIONS
Granulocyte apheresis is a safe and well tolerated therapeutic modality that can be a valid therapeutic alternative in the induction of remission in inflammatory bowel disease, although controlled clinical trials must be conducted to define long-term efficacy, as well as to establish "optimal patient" selection, re-treatment interval, and number of sessions.
Cuenca
F
F
Service of Digestive Diseases, IBD Unit, Hospital Clínico San Carlos. Madrid, Spain. cuencaalarcon@yahoo.com
García Paredes
J
J
Mendoza
J L
JL
Cruz
D M
DM
Herrero
A
A
Díaz-Rubio
M
M
D000328:Adult; D003424:Crohn Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D008875:Middle Aged; D018579:Patient Selection; D019233:Retreatment; D016896:Treatment Outcome