Heparin-induced thrombocytopenia presenting with thrombosis of multiple saphenous vein grafts and myocardial infarction.
We report herein a patient with coronary artery disease that developed heparin-induced thrombocytopenia after coronary artery bypass graft with resulting thrombosis of multiple saphenous vein grafts and myocardial infarction after heparin exposure. The patient required lepirudin and a cardiac catheterization with placement of stents.
Division of Hematology/Oncology, University of Miami School of Medicine/Jackson Memorial Hospital and Veterans Affairs Medical Center, Miami, Florida, USA. ayalae@moffitt.usf.edu
Ernesto
E
Ayala
Manuel F
MF
Rosado
Daniel
D
Morgensztern
Mohamed A
MA
Kharfan-Dabaja
John J
JJ
Byrnes
D000787:Angina Pectoris / Q000601:surgery; D000800:Angioplasty, Balloon; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000276:immunology; D006328:Cardiac Catheterization; D001026:Coronary Artery Bypass / Q000379:methods; D023903:Coronary Restenosis / Q000150:complications / Q000628:therapy; D004359:Drug Therapy, Combination; D000077542:Eptifibatide; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006629:Hirudins / Q000031:analogs & derivatives; D006801:Humans; D007387:Internal Mammary-Coronary Artery Anastomosis; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use; D010978:Platelet Factor 4 / Q000276:immunology; D011183:Postoperative Complications / Q000209:etiology*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D012501:Saphenous Vein / Q000637:transplantation; D015607:Stents; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D013927:Thrombosis / Q000209:etiology*
D000925:Anticoagulants; D001323:Autoantibodies; D001324:Autoantigens; D006495:Heparin, Low-Molecular-Weight; D006629:Hirudins; D010455:Peptides; D011994:Recombinant Proteins; D010978:Platelet Factor 4; D000077542:Eptifibatide; C083544:lepirudin