Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis.
BACKGROUND
KC 11458, a motilin agonist without antibiotic properties, accelerates gastric emptying in animals and healthy humans.


OBJECTIVE
To evaluate the acute effects of KC 11458 on gastric emptying in diabetic gastroparesis.


METHODS
Twenty-nine patients (6 type 1 and 23 type 2) with gastroparesis underwent assessments of: (i) gastric emptying of a solid/liquid meal using scintigraphy, (ii) glycaemic control (blood glucose at 0, 30, 60, 90 and 120 min during the gastric emptying measurement) and (iii) upper gastrointestinal and 'meal-related' symptoms (questionnaire), at baseline and after treatment with KC 11458 in a dose of 8 mg t.d.s., or placebo for 8 days.


RESULTS
KC 11458 had no statistically significant or clinically relevant effect on gastric emptying of either the solid intragastric retention at 100 min (T100) (P = 0.87) or liquid 50% emptying time (T50) (P = 0.17) components of the meal. KC 11458 slightly worsened (P = 0.04) upper gastrointestinal symptoms when compared with placebo. The magnitude of the change in solid gastric emptying correlated with the change in the blood glucose concentration (r = 0.49; P < 0.05).


CONCLUSIONS
KC 11458, in a dose of 8 mg t.d.s. for 8 days, does not accelerate gastric emptying in patients with diabetic gastroparesis. The absence of efficacy may relate to an effect of hyperglycaemia.
Department of Medicine, Royal Adelaide Hospital, University of Adelaide, Australia.
A
A
Russo
J E
JE
Stevens
N
N
Giles
G
G
Krause
D G
DG
O'Donovan
M
M
Horowitz
K L
KL
Jones
D001342:Autonomic Nervous System Diseases / Q000097:blood / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000097:blood / Q000503:physiopathology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D018589:Gastroparesis / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000037:antagonists & inhibitors*
D001786:Blood Glucose; C493967:KC 11458; D009037:Motilin; D004917:Erythromycin