Vascular disease/risk and late-life depression in a Korean community population.
BACKGROUND
Associations between vascular risk factors and late-life depression are controversial.


OBJECTIVE
To investigate the association between measures of vascular disease/risk and depression and confounding and effect modification by APOE genotype and cognitive function.


METHODS
In a Korean community population aged 65+ (n=732), diagnosis of depression (Geriatric Mental State Schedule) and information on vascular status, disability, APOE genotype and cognitive function were obtained.


RESULTS
Previous stroke and lower high-density lipoprotein cholesterol level (but neither hypertension nor diabetes) were significantly associated with depression (independently of disability and cognitive function). These associations were stronger in participants with borderline cognitive impairment, although not to a significant extent.


CONCLUSIONS
Except for previous stroke and an atherogenic lipid profile, associations between depression and other common risk factors for cerebrovascular disease were not evident.
Department of Psychiatry, Chonnam University Medical School, 5 Hak-dong, Dong-Ku, Kwangju, 501-757, Republic of Korea. jsyoon@chonnam.ac.kr
Jae-Min
JM
Kim
Robert
R
Stewart
Il-Seon
IS
Shin
Jin-Sang
JS
Yoon
D000368:Aged; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics; D003072:Cognition Disorders / Q000209:etiology; D003866:Depressive Disorder / Q000209:etiology* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D020521:Stroke / Q000235:genetics / Q000523:psychology; D014652:Vascular Diseases / Q000235:genetics / Q000523:psychology*
D001057:Apolipoproteins E