Cytomegalovirus and lung transplantation.
Cytomegalovirus (CMV) infection remains a serious problem in lung transplant recipients. Development of potent oral antiviral agents, molecular techniques for the detection of infection and its response to therapy and the emergence of isolates with antiviral resistance have had significant impacts on the approach to CMV in these patients. This article discusses the following issues as part of a comprehensive CMV management strategy in lung transplant recipients: (1) Prevention strategies in the era of potent oral antiviral agents, (2) the role of new diagnostic techniques in the management of CMV, (3) treatment regimens for established CMV infection or disease, (4) the potential impact of treatment of CMV on the indirect effects on long-term allograft function, and (5) the incidence, risk factors for and impact of ganciclovir resistance following lung transplantation.
Division of Pulmonary Sciences and Critical Care Medicine, and the Lung Transplant Program, University of Colorado Health Sciences Center, Denver, CO, USA. Marty.Zamora@uchsc.edu
Martin R
MR
Zamora
D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000517:prevention & control*; D004351:Drug Resistance; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008168:Lung / Q000821:virology*; D016040:Lung Transplantation / Q000379:methods*; D016377:Organ Transplantation / Q000009:adverse effects*; D016133:Polymerase Chain Reaction; D013997:Time Factors
D000998:Antiviral Agents; D007136:Immunoglobulins; D015774:Ganciclovir