Signal transduction mechanisms in Trypanosoma cruzi.
Trypanosoma cruzi, the etiological agent of Chagas disease, is an adequate model for studies on the evolution of signal transduction pathways. These pathways involve molecular entities such as membrane receptors, transduction G proteins, protein kinases and second messengers (Ca(2+), cyclic AMP, cyclic GMP, nitric oxide). In this article, Mirtha M. Flawiá, María T. Téllez-Iñón and Héctor N. Torres describe the studies performed on T. cruzi transduction pathways and their role in the control of metacyclogenesis and cell motility.
Instituto de investigaciones en Ingenieria Genética y Biología Molecular (CONICET and Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires), Vuelta de Obligado 2490. 1428 Buenos Aires, Argentina.
M M
MM
Flawiá
M T
MT
Téllez-Iñón
H N
HN
Torres