The hand in metastatic disease and acral manifestations of paraneoplastic syndromes.
Metastatic tumors to the hand and wrist are rare, accounting for approximately 0.1% of all metastatic lesions to the skeleton. The biochemically mediated pathways of bone metastases, the location of the hand at the distal extremity, and the small amount of marrow in the bones of the hand and wrist account for the low prevalence of acrometastases. More rarely, hand dermatologic and soft tissue changes of paraneoplastic syndromes herald an occult malignancy.
Division of Hand, Elbow, and Microsurgery, Department of Orthopaedic Surgery, University of Michigan Medical Center, 2098 South Main Street, Ann Arbor, MI 48103, USA. rhayden@umich.edu
Radford J
RJ
Hayden
Lawrence G
LG
Sullivan
Peter J L
PJ
Jebson
D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000556:secondary* / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology; D003475:Curettage; D005385:Fingers; D006225:Hand; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging; D010257:Paraneoplastic Syndromes; D010808:Physical Examination; D011379:Prognosis; D014057:Tomography, X-Ray Computed