Triadin: a multi-protein family for which purpose?
Triadin is a protein first identified as a member of the muscle calcium release complex, involved in calcium release for muscle contraction. However, its precise function in this complex is still undefined. Recently, triadin has been shown to be a multi-protein family, with different distribution of the various splice variants within the sarcoplasmic reticulum, raising the possibility of multiple functions for this family of polypeptides. Such functions may include involvement in excitation-contraction coupling, in triad targeting, in structural function or in muscle differentiation. The putative role(s) of triadin(s) will be discussed here.
Marty
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INSERM 607, CIS, DRDC/CEA Grenoble, 17 rue des Martyrs, 38054, Grenoble cedex 9, France. imarty@cea.fr
D000818:Animals; D002118:Calcium / Q000502:physiology; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D005810:Multigene Family; D009124:Muscle Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009928:Organ Specificity; D020033:Protein Isoforms / Q000235:genetics / Q000502:physiology
D002352:Carrier Proteins; D009124:Muscle Proteins; D020033:Protein Isoforms; C498269:TRDN protein, human; C070048:triadin; D002118:Calcium