Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides.
The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.
Giacometti
Andrea
A
Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy. anconacmi@interfree.it
Cirioni
Oscar
O
Ghiselli
Roberto
R
Orlando
Fiorenza
F
D'Amato
Giuseppina
G
Kamysz
Wojciech
W
Mocchegiani
Federico
F
Sisti
Valerio
V
Silvestri
Carmela
C
Łukasiak
Jerzy
J
Rocchi
Marco
M
Saba
Vittorio
V
Scalise
Giorgio
G
D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides; D001807:Blood Vessel Prosthesis; D015169:Colony Count, Microbial; D024881:Drug Resistance, Bacterial; D004357:Drug Synergism; D006020:Glycopeptides / Q000494:pharmacology*; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000008:administration & dosage / Q000627:therapeutic use*; D019999:Pharmaceutical Solutions; D011093:Polyethylene Terephthalates; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D011506:Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D013212:Staphylococcus epidermidis
D000081:Acetamides; D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D006020:Glycopeptides; D023303:Oxazolidinones; D019999:Pharmaceutical Solutions; D011093:Polyethylene Terephthalates; D011506:Proteins; C104501:temporin; D000069349:Linezolid