[Clinical comparison of isoflurane and sevoflurane anaesthesia in the gerbil (Meriones unguiculatus)].
The objective of this study was a comparison of the volatile anaesthetics isoflurane and sevoflurane in terms of their clinical effects in gerbils (Meriones unguiculatus) (n=12 each). Induction of anaesthesia was performed in a body chamber with an anaesthetic concentration of 4.0 Vol.% at an oxygen flow of 500 ml/min for isoflurane and 8.0 Vol.% at an oxygen flow of 1000 ml/min for sevoflurane, respectively. Anaesthesia was maintained via nose cone with an anaesthetic concentration of 2.8 to 3.2 Vol.% at an oxygen flow of 200 ml/min for isoflurane and 5.0 to 5.2 Vol.% at an oxygen flow of 400 ml/min for sevoflurane. Those anaesthetic concentrations ensured reflex status conform with surgical tolerance. In spite of its higher blood-gas coefficient induction time was slightly faster for isoflurane. Recovery time was significantly longer in the isoflurane group than it was in the sevoflurane group. Both inhalants caused respiratory depression. Respiratory rate was lower in sevoflurane animals compared to isoflurane. The animals were positioned on a heating pad immediately after induction, thus a decrease of the body temperature could be prevented. Both inhalants can be recommended for usage in gerbils. Sevoflurane showed no clinical benefit compared to isoflurane.
Henke
Julia
J
Institut für Experimentelle Onkologie und Therapieforschung, Technische Universität München. julia.henke@lrz.tum.de
Strack
Tanja
T
Erhardt
Wolf
W
D000769:Anesthesia, Inhalation / Q000379:methods / Q000662:veterinary*; D018685:Anesthetics, Inhalation; D000818:Animals; D005260:Female; D005849:Gerbillinae / Q000502:physiology*; D007530:Isoflurane; D008297:Male; D008738:Methyl Ethers; D011897:Random Allocation; D000077149:Sevoflurane; D016896:Treatment Outcome
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane