[Meningococcal purpura fulminans in children].
In France, the incidence of meningococcal infections is increasing and the most severe presentation, called purpura fulminans, has still a death rate of 20-25%. Diagnosis of invasive meningococcal infection must be evoked in any child presenting with febrile purpura (vasculitic rash not disappearing with "tumbler test"); a fulminating form must be suspected in the presence of only one ecchymosis and signs of infection, remembering that recognition of shock is difficult in children. The Health Authority recommend to administer a third generation cephalosporin promptly for any child with signs of infection and an ecchymotic purpura (>3 mm of diameter), and then to refer the patient to the hospital. Children with purpura fulminans should be referred to a paediatric intensive care unit. Management includes antibiotics, steroids, fluid resuscitation and catecholamines (be aware of hypoglycaemia, particularly in infants, and hypocalcaemia). Treatment of cutaneous necrosis and distal ischemia is difficult and still controversial: antithrombin, protein C, tissue plasminogen activator and vasodilator infusion have no proved efficacy. Cases must be rapidly notified to the Public Health Service who will institute chemoprophylaxis for close contacts. Given the predominance of serogroup B in France, we hope that an efficient vaccine will soon become available.
Réanimation pédiatrique, hôpital Jeanne de Flandre, CHU de Lille, 59037 Lille Cedex. fleclerc@chru-lille.fr
Francis
F
Leclerc
Alexandra
A
Binoche
François
F
Dubos
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D007223:Infant; D008589:Meningococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000628:therapy