High prevalence of extended-spectrum beta-lactamase-producing strains among blood isolates of Enterobacter spp. collected in a tertiary hospital during an 8-year period and their antimicrobial susceptibility patterns.
Of 72 blood isolates of Enterobacter spp. collected over an 8-year period, 50% (36 of 72) were derepressed or partially derepressed AmpC mutants. The extended-spectrum beta-lactamase (ESBL) production rate was 43% (31 of 72 isolates), and 67.3% (31 of 46) of extended-spectrum cephalosporin-resistant strains produced ESBLs. Thus, a confirmatory test for ESBL production is necessary for extended-spectrum cephalosporin-resistant Enterobacter spp.
Division of Infectious Disease, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. paihj@hanyang.ac.kr
Hyunjoo
H
Pai
Jung Yun
JY
Hong
Jeong-Hum
JH
Byeon
Yun-Kyung
YK
Kim
Hoan-Jong
HJ
Lee
D000890:Anti-Infective Agents / Q000494:pharmacology*; D000077723:Cefepime; D018550:Cephalosporin Resistance / Q000235:genetics; D002511:Cephalosporins / Q000494:pharmacology; D003428:Cross Infection / Q000097:blood / Q000382:microbiology*; D004754:Enterobacter / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000097:blood / Q000382:microbiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005787:Gene Frequency; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D000890:Anti-Infective Agents; D002511:Cephalosporins; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D000077723:Cefepime; D001618:beta-Lactamases