The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits.
Iron deficiency (ID) is among the most common nutritional diseases, causing deleterious effects that include decreases in cognitive function and weight loss. The ID also induces a reduction in the number and affinity of dopaminergic D2 receptors. The new finding that ID induces an increase in the pancreas cells, leads to the hypothesis that cholecystokinin-8 (CCK-8) is involved in the ID effects. The level of CCK-8 was higher among ID rats, compared with normal rats. The ID rats in our study were anorectic and performed poorly in learning tests (Morris water maze and passive avoidance learning). Essential fatty acids (EFA) mediate dopamine activity and have been found to rehabilitate learning deficits. Treatment with a fatty acid compound blocked both the learning deficits and the anorexia, while a CCK-8 antagonist was successful only against the anorectic effects.
Psychopharmacology Laboratory, Department of Psychology and Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel. yehudas@mail.biu.ac.il
Shlomo
S
Yehuda
David I
DI
Mostofsky
D000821:Animal Feed; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000097:blood; D002149:Energy Intake; D006727:Hormone Antagonists / Q000494:pharmacology; D000090463:Iron Deficiencies; D007515:Islets of Langerhans / Q000033:anatomy & histology / Q000187:drug effects; D019787:Linoleic Acid / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010446:Peptide Fragments / Q000037:antagonists & inhibitors* / Q000097:blood; D011377:Proglumide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D013550:Swimming; D015430:Weight Gain
D006727:Hormone Antagonists; D010446:Peptide Fragments; C410885:cholecystokinin 8; C053737:loxiglumide; D002766:Cholecystokinin; D019787:Linoleic Acid; D011377:Proglumide