Rheumatoid arthritis increases the risk of coronary heart disease via vascular endothelial injuries.
Patients with rheumatoid arthritis (RA) have an increased prevalence of coronary heart disease and a high cardiovascular mortality rate. The causes of increased coronary heart disease in RA patients are poorly understood. Conventional cardiovascular risk factors, such as inactivity, overweight or dyslipidemia may play a role, but they do not seem to be wholly responsible for the increased cardiovascular risk. RA is associated with a high incidence of inflammation and vascular endothelial injuries. Endothelial dysfunction is one of the key steps in the pathogenesis of atherosclerosis in non-RA patients. Therefore, we hypothesized that inflammation-induced vascular endothelial injuries may be responsible for the increased risk of coronary heart disease and high rates of cardiovascular mortality in patients with RA.
School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia. lwang@csu.edu.au
Lexin
L
Wang
Guoqin
G
Feng
D001172:Arthritis, Rheumatoid / Q000453:epidemiology* / Q000276:immunology*; D015984:Causality; D002986:Clinical Trials as Topic; D015897:Comorbidity; D003327:Coronary Disease / Q000453:epidemiology* / Q000276:immunology*; D004198:Disease Susceptibility / Q000453:epidemiology / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology* / Q000293:injuries; D006801:Humans; D008955:Models, Cardiovascular; D018448:Models, Immunological; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014657:Vasculitis / Q000453:epidemiology* / Q000276:immunology*