Safe and efficacious prolonged use of an olive oil-based lipid emulsion (ClinOleic) in chronic intestinal failure.
OBJECTIVE
Injectable lipid emulsion is an important component of parenteral nutrition. ClinOleic is a lipid emulsion composed of olive oil (80%) and soybean oil (20%). This study evaluated the efficacy and safety of ClinOleic in adults already receiving parenteral nutrition, comparing it to their usual lipid (soybean-oil-based).


METHODS
Thirteen adults dependent on home parenteral nutrition were recruited from a single hospital. ClinOleic was administered for 6 months. Two-monthly assessments were made. In addition, clinical and adverse events were recorded for 6-month periods before, during and after the study.


RESULTS
Total numbers of important complications for the 6 months before, during and after the study were 13, 9 and 9, respectively. There were, respectively, 5, 3 and 2 line infections, and 2, 0 and 5 thrombotic episodes in the 3 periods. The numbers of unplanned admissions were, respectively, 8, 5 and 7, with in-patient days accounting for 3.4%, 1.5%, and 2.6% of feeding days, respectively. One patient died (pneumonia). One new case of cholecystolithiasis appeared.


CONCLUSIONS
ClinOleic may be used as a safe alternative to standard soybean-oil-based lipid emulsions.
Thomas-Gibson
Siwan
S
St. Mark's Hospital, Watford Road, Harrow HA1 3UJ, UK.
Jawhari
Aida
A
Atlan
Philippe
P
Brun
A L Alexia Le
AL
Farthing
Michael
M
Forbes
Alastair
A
D000328:Adult; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D016331:Parenteral Nutrition, Home / Q000009:adverse effects / Q000379:methods*; D010938:Plant Oils; D011446:Prospective Studies; D012189:Retrospective Studies; D012449:Safety; D016896:Treatment Outcome
D005217:Fat Emulsions, Intravenous; D000069463:Olive Oil; D010938:Plant Oils