Effects of Central Kalimantan plant extracts on intraerythrocytic Babesia gibsoni in culture.
The inhibitory effects of 45 plant extracts selected from Central Kalimantan, Indonesia on Babesia gibsoni in vitro and their acute toxicity to mice were evaluated. Of these plant extracts studied, Arcangelisia flava, Curcuma zedoaria, Garcinia benthamiana, Lansium domesticum and Peronema canescens were found to have appreciable antibabesial activity with IC50 values from 5.3 to 49.3 microg/ml without acute toxicity in mice at the intraperitoneal dose of 0.7 g/kg of body weight.
Subeki
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Matsuura
Hideyuki
H
Yamasaki
Masahiro
M
Yamato
Osamu
O
Maede
Yoshimitsu
Y
Katakura
Ken
K
Suzuki
Mamoru
M
Trimurningsih
Chairul
Yoshihara
Teruhiko
T
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001403:Babesia / Q000187:drug effects*; D007214:Indonesia; D020128:Inhibitory Concentration 50; D007274:Injections, Intraperitoneal / Q000662:veterinary; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D018517:Plant Roots; D018547:Plant Stems; D027343:Rhizome
D000981:Antiprotozoal Agents; D010936:Plant Extracts