Amplification of T-cell responses by neutrophils: relevance to allograft immunity.
Because rejection of allografts is primarily caused by T and B lymphocyte responses to allogenic histocompatibility molecules, the role of innate immunity in organ transplant rejection is often overlooked. However, the very first damages to vascularized organ allografts are caused by ischemia-reperfusion, an inflammatory reaction involving activation of vascular endothelial cells and release of neutrophil chemoattractants. Herein, we review experimental observations suggesting that the early neutrophil influx in organ transplants favors T cell-mediated rejection.
Buonocore
Sofia
S
Department of Immunology, Institute for Medical Immunology and Hôpital Erasme, Université Libre de Bruxelles, 808 route de Lennik, B-1070 Brussels, Belgium.
Surquin
Muriel
M
Le Moine
Alain
A
Abramowicz
Daniel
D
Flamand
Véronique
V
Goldman
Michel
M
D002454:Cell Differentiation / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014184:Transplantation, Homologous