Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations.
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P=.0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.
Wadsworth Center, NY State Department of Health, Albany, New York 12208, USA.
Guowei
G
Fang
Carla
C
Kuiken
Barbara
B
Weiser
Sarah
S
Rowland-Jones
Francis
F
Plummer
Chih-Hsiung
CH
Chen
Rupert
R
Kaul
Aggrey Omu
AO
Anzala
Job
J
Bwayo
Joshua
J
Kimani
Sean M
SM
Philpott
Christina
C
Kitchen
Janet S
JS
Sinsheimer
Brian
B
Gaschen
Dorothy
D
Lang
Binshan
B
Shi
Kimdar Sherefa
KS
Kemal
Tim
T
Rostron
Cheryl
C
Brunner
Simon
S
Beddows
Quentin
Q
Sattenau
Ellen
E
Paxinos
Julius
J
Oyugi
Harold
H
Burger
D000328:Adult; D000483:Alleles; D018932:Chemokine CCL2 / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000472:pathogenicity; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008969:Molecular Sequence Data; D009784:Occupational Diseases / Q000453:epidemiology*; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000097:blood / Q000235:genetics*; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000235:genetics; D011477:Sex Work
C515334:CCR2 protein, human; D018932:Chemokine CCL2; D006680:HLA Antigens; D012367:RNA, Viral; D054390:Receptors, CCR2; D019707:Receptors, Chemokine