Acute infection of swine by various Salmonella serovars.
The objective of this study was to evaluate the ability of various serovars of Salmonella enterica subsp. enterica to infect alimentary and nonalimentary tissues of swine within 3 h of inoculation. Fourteen wild-type S. enterica serovars (4,12:imonophasic, 6,7 nonmotile, Agona, Brandenburg, Bredeney, Derby, Heidelberg, Infantis, Muenchen, Thompson, Typhimurium, Typhimurium variant Copenhagen, untypeable, and Worthington), two known virulent S. enterica serovars (Choleraesuis strain SC-38 and Typhimurium strain chi4232), and two avirulent S. enterica Choleraesuis vaccine strains (Argus and SC-54) were inoculated intranasally (approximately 5 x 10(9) cells) into swine (four animals per Salmonella isolate). Three hours after inoculation, animals were euthanized, and both alimentary tissues (tonsil, colon contents, and cecum contents) and nonalimentary tissues (mandibular lymph node, thymus, lung, liver, spleen, ileocecal lymph node, and blood) were collected for Salmonella isolation. All Salmonella serovars evaluated except Salmonella Choleraesuis SC-54 acutely infected both alimentary and nonalimentary tissues. These results indicate that Salmonella isolates commonly found in swine are capable of acutely infecting both alimentary and nonalimentary tissues in a time frame consistent with that in which animals are transported and held in lairage prior to slaughter.
Department of Veterinary Microbiology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA. bosshog@iastate.edu
A T
AT
Loynachan
J M
JM
Nugent
M M
MM
Erdman
D L
DL
Harris
D000208:Acute Disease; D000281:Administration, Intranasal; D000818:Animals; D004197:Disease Reservoirs / Q000662:veterinary; D005506:Food Contamination; D005516:Food Microbiology; D011897:Random Allocation; D012481:Salmonella Infections, Animal / Q000382:microbiology* / Q000473:pathology; D019779:Salmonella enterica / Q000472:pathogenicity*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology* / Q000473:pathology; D013997:Time Factors; D014186:Transportation