Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol.
Cardioprotective effect of ethanolic extract of Terminalia chebula fruits (500 mg/kg body wt) was examined in isoproterenol (200 mg/kg body wt) induced myocardial damage in rats. In isoproterenol administered rats, the level of lipid peroxides increased significantly in the serum and heart. A significant decrease was observed in the activity of the myocardial marker enzymes with a concomitant increase in their activity in serum. Histopathological examination was carried out to confirm the myocardial necrosis. T. chebula extract pretreatment was found to ameliorate the effect of isoproterenol on lipid peroxide formation and retained the activities of the diagnostic marker enzymes.
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.
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Suchalatha
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Shyamala Devi
D000318:Adrenergic beta-Agonists / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D005638:Fruit / Q000737:chemistry; D006321:Heart / Q000187:drug effects / Q000502:physiology; D007545:Isoproterenol / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D009203:Myocardial Infarction / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D009336:Necrosis; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D029766:Terminalia / Q000737:chemistry*
D000318:Adrenergic beta-Agonists; D008054:Lipid Peroxides; D010936:Plant Extracts; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007545:Isoproterenol