Chemical biology of multi-host/pathogen interactions: chemical perception and metabolic complementation.
The xenognostic mechanisms of two multi-host pathogens, the causative agent of crown gall tumors Agrobacterium tumefaciens and the parasitic plant Striga asiatica, are compared. Both organisms are general plant pathogens and require similar information prior to host commitment. Two mechanistic strategies, chemical perception and metabolic complementation, are used to ensure successful host commitment. The critical reactions at host-parasite contact are proton and electron transfer events. Such strategies may be common among multi-host pathogens.
Palmer
Andrew G
AG
Center for Fundamental and Applied Molecular Evolution, Departments of Chemistry and Biology, Emory University, Atlanta, Georgia 30322, USA.
Gao
Rong
R
Maresh
Justin
J
Erbil
W Kaya
WK
Lynn
David G
DG
D016960:Agrobacterium tumefaciens / Q000502:physiology*; D000818:Animals; D006790:Host-Parasite Interactions; D010941:Plant Tumors / Q000469:parasitology; D010944:Plants / Q000469:parasitology*; D034362:Striga / Q000502:physiology*