Benzoic acid inhibitors of influenza virus neuraminidase.
A strategy was developed to design non-carbohydrate inhibitors of influenza virus neuraminidase. Using an iterative cycle of modeling, synthesis, biological testing and X-ray crystallography structure determination, a series of inhibitors based on benzoic acid were produced. The refined structures of three compounds complexed with neuraminidase are reported. The results demonstrate the success of this structure-based drug-design strategy.
Center for Macromolecular Crystallography, Department of Microbiology, University of Alabama at Birmingham, 35294, USA.
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M
Luo
M J
MJ
Jedrzejas
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S
Singh
C L
CL
White
W J
WJ
Brouillette
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Air
W G
WG
Laver