Wheel running use in dopamine D2L receptor knockout mice.
The present study investigated the role of dopamine and the opioid system in the acquisition and maintenance of wheel running use (WR), employing D2L receptor-deficient (D2L-/-) mice as a model system. The daily administration of 1mg/kg of naloxone virtually abolished the acquisition of WR in D2L-/-, but did not modify the number of wheel turns after the consolidation of this behavior. These findings imply that both dopamine and opioid reward systems are necessary for WR consolidation, and they also suggest that reward systems in WR could vary according to the motivational stage of the animal.
Departamento de Neurobiología Conductual y Cognitiva, Facultad de Medicina, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Apartado postal 1-1141, Querétaro, Qro. 76001 México, Mexico. vargas@calli.inb.unam.mx
Héctor
H
Vargas-Pérez
Emiliana
E
Borrelli
José-Luis
JL
Díaz
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D065127:Dopamine D2 Receptor Antagonists; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009270:Naloxone / Q000494:pharmacology; D018847:Opioid Peptides / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000502:physiology*; D012054:Reinforcement, Psychology
D065127:Dopamine D2 Receptor Antagonists; D018847:Opioid Peptides; D017448:Receptors, Dopamine D2; C113776:dopamine D2L receptor; D009270:Naloxone