Daptomycin structure and mechanism of action revealed.
Daptomycin kills otherwise antibiotic-resistant gram-positive pathogens and is the first lipopeptide antibiotic to reach the clinic. Elucidation of its 3D structure and mechanism of action, reported in this issue of Chemistry & Biology, will facilitate the design and engineering of new, potentially life-saving antibiotics.
Micklefield
Jason
J
Department of Chemistry, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, United Kingdom.
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D017576:Daptomycin / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D017576:Daptomycin