Polysulfane antitumor agents from o-benzyne. An odd-even alternation found in the stability of products o-C6H4Sx (x = 1-8).
Benzyne is shown to add elemental sulfur and give rise to a series of polysulfane compounds. A computational and experimental study is presented. Odd-membered o-C6H4Sx rings (x = 1-8), except x = 1, which suffers from ring strain, have enhanced stability compared to even-membered rings. The acquisition of "odd-even" data may shed new light, revealing patterns on polysulfane stability and structure.
Department of Chemistry, Graduate School and University Center & The City University of New York (CUNY), Brooklyn College, Brooklyn, New York 11210, USA.
Edyta M
EM
Brzostowska
Alexander
A
Greer
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000737:chemistry*; D003500:Cyclization; D008962:Models, Theoretical; D008968:Molecular Conformation; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013457:Sulfur Compounds / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D013457:Sulfur Compounds