A novel antifungal pyrrole derivative from Datura metel leaves.
Phytochemical investigation of the leaves of Datura metel Linn. led to the isolation of a new pyrrole derivative 1 which was characterised as 2beta-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1'-methylethyl pentanoate on the basis of spectral data analyses and chemical reactions. Compound 1 was endowed with antifungal activity and its MIC was found to be 87.5 microg/ml. Two proteins having molecular weights of 42 and 58 kD of Aspergillus fumigatus are potential targets for compound 1.
Dabur
R
R
Institute of Genomics and Integrative Biology (CSIR), Delhi University Campus, Delhi, India.
Ali
M
M
Singh
H
H
Gupta
J
J
Sharma
G L
GL
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D032302:Datura / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D005656:Fungal Proteins / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014631:Valerates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
C488953:2beta-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1'-methylethyl pentanoate; D000935:Antifungal Agents; D005656:Fungal Proteins; D007202:Indicators and Reagents; D010936:Plant Extracts; D011758:Pyrroles; D012997:Solvents; D014631:Valerates