[TT virus and hepatitis G virus in different risk groups in Afyon].
The main transmission route of TT virus (Transfusion-Transmitted Virus, TTV) and hepatitis G virus (HGV) is by parenteral route of blood and blood-products. Since they form the same risk group, some of TTV or HGV positive patients may also be infected by hepatitis B virus (HBV) and/or hepatitis C virus (HCV). In this study, the presence of TTV and HGV has been investigated by reverse transcriptase-polymerase chain reaction (RT-PCR, GeneAmp 5700 Sequence Detection System, AB), in 40 hepatitis B, 30 hepatitis C and 5 hepatitis B and C co-infected patients, 50 HBV and HCV negative hemodialysis patients, and 50 randomly selected healthy blood donors. As a result, 37 (21.1%) TTV and 11 (6.3%) HGV positivity were detected, out of a total 175 cases. The positivity rates for TTV and HGV were found as 40% and 5% in HBV-positive, 23.3% and 20% in HCV-positive, 20% and 20% in HBV+HCV co-infected patients, 20% and 4% in hemodialysis patients, and 6% and 0% in healthy blood donors, respectively. In conclusion, as the positivity rates were not low for these viruses, their role on the hepatitis pathogenesis should be further investigated by detailed studies.
Altindiş
Mustafa
M
Afyon Kocatepe Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Afyon.
Aktepe
Orhan Cem
OC
Cetinkaya
Zafer
Z
Ozdemir
Müjgan
M
D000328:Adult; D001782:Blood Donors; D018173:Circoviridae Infections / Q000150:complications / Q000453:epidemiology*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D029407:GB virus C / Q000235:genetics / Q000302:isolation & purification*; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology*; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification*; D065227:Transfusion Reaction; D014421:Turkey / Q000453:epidemiology
D004279:DNA, Viral; D012367:RNA, Viral