Chipping away at 'stemness'.
Global gene-expression analyses of human embryonic stem cells confirm the involvement of some known genes in stem-cell function and identify some new candidate regulators of stem-cell growth. Support remains elusive, however, for the concept of 'stemness'--a pattern of expression of genes that is common to all stem cells.
Germ Cell and Stem Cell Group, Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. pjdonovan@jhmi.edu
April D
AD
Pyle
Peter J
PJ
Donovan
Leslie F
LF
Lock
D002454:Cell Differentiation / Q000235:genetics*; D004622:Embryo, Mammalian / Q000166:cytology* / Q000378:metabolism*; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics*