The roles of MAPK cascades in synaptic plasticity and memory in Aplysia: facilitatory effects and inhibitory constraints.
Synaptic plasticity is thought to contribute to memory formation. Serotonin-induced facilitation of sensory-motor (SN-MN) synapses in Aplysia is an extensively studied cellular analog of memory for sensitization. Serotonin, a modulatory neurotransmitter, is released in the CNS during sensitization training, and induces three temporally and mechanistically distinct phases of SN-MN synaptic facilitation. The role of protein kinase A and protein kinase C in SN-MN synaptic facilitation is well documented. Recently, it has become clear that mitogen-activated protein kinase (MAPK) cascades also play a critical role in SN-MN plasticity. Here, we summarize the roles of MAPK cascades in synaptic plasticity and memory for sensitization in Aplysia.
Sharma
Shiv K
SK
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697, USA.
Carew
Thomas J
TJ
D000818:Animals; D001048:Aplysia / Q000201:enzymology*; D001245:Association Learning / Q000502:physiology; D003213:Conditioning, Psychological / Q000502:physiology; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009046:Motor Neurons / Q000201:enzymology; D009473:Neuronal Plasticity / Q000502:physiology*; D009475:Neurons, Afferent / Q000201:enzymology; D012701:Serotonin / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000201:enzymology*
D012701:Serotonin; D020928:Mitogen-Activated Protein Kinases