[Proposal for a discriminant level of BNP in very elderly persons with heart failure].
A diagnosis of heart failure (HF) in elderly patient can be difficult. The purpose of this study is to evaluate the cut-off of brain natriuretic peptide (BNP) Triage Assay (Biosite) in the diagnosis of HF in this population : 250 very older patients with age <or= 75 years (mean 82.7 years) were included in this study; 180 patients were diagnosed with HF based on clinical and echocardiographic findings. The sensibility is of 95% at 100 ng/L versus 83% at 300 ng/L. The specificity is of 21% versus 50% at 300 ng/L. The positive predictive value is of 17% at 100 ng/L versus 23% at 300 ng/L. The negative predictive value is of 96% at 100 ng/L versus 95% at 300 pg/L. The cut-off set at 300 ng/L is more suitable as HF marker in the very old population.
Laboratoire de biologie, Claude Bernard. redha ababsa@ch-pontoise.fr
R
R
Abadsa
P
P
Jourdain
N
N
Sadeg
P
P
Deschamps
C
C
Jacoly
F
F
Funck
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002845:Chromatography; D017023:Coronary Angiography; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D004417:Dyspnea / Q000209:etiology; D004452:Echocardiography; D004638:Emergency Treatment / Q000379:methods / Q000592:standards; D005260:Female; D005455:Fluorescent Antibody Technique; D005602:France / Q000453:epidemiology; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods / Q000592:standards; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D015995:Prevalence; D012372:ROC Curve; D012016:Reference Values
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain