Behavioral and physiological adaptation to repeated chair restraint in rhesus macaques.
Physical restraint is a commonly used procedure when working closely with nonhuman primates. Nonhuman primates show rapid behavioral changes when learning the restraint procedure, and these changes have been taken to reflect behavioral and physiological habituation to the procedure. This study examined the behavioral and adrenocortical responses to repeated physical restraint in a large sample of adult male rhesus monkeys. Subjects showed a decline in behavioral agitation and cortisol concentrations across seven consecutive days of restraint. The changes in adrenocortical responsiveness were also coincident with an increased sensitivity to dexamethasone and a change in early morning basal cortisol secretion. The subjects were restrained for a single session 6 months later, and while the reduction in behavioral agitation was still present, the majority of changes in adrenocortical responsiveness were no longer present. These data show that behavior is not necessarily an indicator of underlying physiological processes and that the reduction of hypothalamic-pituitary-adrenal (HPA) activity with repeated restraint is due to physiological adaptation to high glucocorticoid concentrations and not to psychological habituation to the restraint procedures.
Ruys
J D
JD
Animal Behavior Graduate Group, California National Primate Research Center, Department of Psychology, University of California, One Shields Avenue, Davis 95616, USA.
Mendoza
S P
SP
Capitanio
J P
JP
Mason
W A
WA
D000222:Adaptation, Physiological; D000223:Adaptation, Psychological / Q000187:drug effects / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D005500:Follow-Up Studies; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology*; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D008253:Macaca mulatta / Q000502:physiology* / Q000523:psychology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology; D012149:Restraint, Physical / Q000502:physiology* / Q000523:psychology*; D013268:Stimulation, Chemical; D013315:Stress, Psychological / Q000097:blood*; D013997:Time Factors
D003907:Dexamethasone; D006854:Hydrocortisone