Peroxisome proliferator-activated receptor gamma; Its role in atherosclerosis and restenosis.
Cellular proliferation and migration are fundamental processes that contribute to the injury response in major blood vessels. The resultant pathologies are atherosclerosis and restenosis. As we begin to understand the cellular changes associated with vascular injury, it is critical to determine whether the inhibition of growth and movement of cells in the vasculature could serve as a novel therapeutic strategy to prevent atherosclerosis and restenosis.
Pakala
Rajbabu
R
Cardiovascular Research Institute, Washington Hospital Center, 110 Irving Street, NW, Suite 4B-1, Washington, DC 20010, USA.
Rha
Seung-Woon
SW
Kuchulakanti
Pramod Kumar
PK
Cheneau
Edouard
E
Baffour
Richard
R
Waksman
Ron
R
D000818:Animals; D015415:Biomarkers / Q000097:blood; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000517:prevention & control; D023903:Coronary Restenosis / Q000517:prevention & control*; D023921:Coronary Stenosis / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D047492:Peroxisome Proliferator-Activated Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D015415:Biomarkers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D047492:Peroxisome Proliferator-Activated Receptors