The chromosomal passenger complex takes center stage during mitosis.
The chromosomal passenger complex plays important roles in key mitotic events, including chromosome bi-orientation, the spindle assembly checkpoint, and cytokinesis. Two groups now report the identification of a novel component of the Incenp/survivin/auroraB complex (Gassmann et al., 2004; Sampath et al., 2004) and show that different subcomplexes may exist during mitosis. Exciting data support the involvement of the passenger complex in yet another key event, the assembly of the mitotic spindle.
Vernos
Isabelle
I
EMBL, Cell Biology and Biophysics Program, Heidelberg 69 117, Germany.
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D002503:Centromere / Q000648:ultrastructure; D002875:Chromosomes / Q000648:ultrastructure*; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000648:ultrastructure; D008938:Mitosis; D008954:Models, Biological; D010766:Phosphorylation; D008941:Spindle Apparatus / Q000378:metabolism