Radiation-induced atypical meningioma with rapid growth in a 13-year-old girl. Case report.
This case illustrates the potential growth rate of an atypical meningioma in a pediatric patient, emphasizes one of the potential risks after therapeutic radiation, and underscores the importance of clinical evaluation and follow up of the symptomatic patient after tumor resection and radiation therapy. The authors report a case of a radiation-induced atypical meningioma of the olfactory groove in a 13-year-old girl who received 36 Gy of radiation to the craniospinal axis and 72 Gy to the primary site of a primitive neuroectodermal epithelial tumor of the left parietooccipital lobe when she was 4 years of age. This tumor was not present on routine magnetic resonance imaging performed 13 months prior to the discovery of this lesion or on computerized tomography scanning obtained 6 months prior to the discovery of this tumor. At the time of its discovery, the tumor was 5 x 5 x 4 cm. This tumor was resected and the patient's symptoms improved. This case illustrates the importance of continued close follow up after cranial irradiation in the pediatric population.
Department of Neurological Surgery (Division of Pediatric Neurosurgery and Brain Tumor Research Center), University of California, San Francisco Medical Center, San Francisco, California 94143-0112, USA. warem@neurosurg.ucsf.edu
Marcus L
ML
Ware
Soonmee
S
Cha
Nalin
N
Gupta
Victor L
VL
Perry
D000293:Adolescent; D001932:Brain Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000209:etiology* / Q000601:surgery; D008579:Meningioma / Q000209:etiology* / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000601:surgery; D018242:Neuroectodermal Tumors, Primitive / Q000532:radiotherapy*