Homocysteine and antiphospholipid antibodies in a woman undergoing ovarian follicular stimulation: prospective clinical and laboratory evaluation.
This is the case of a 28-year-old woman in apparently good health, who had an ischemic stroke and significant proteinuria developed during her first attempt of in vitro fertilization. She was evaluated for inherited and acquired thrombophilia and tested positive for high titer of antiphospholipid antibodies and mild hyperhomocysteinemia. The potential thrombotic risks associated with in vitro fertilization will be discussed.
Grandone
Elvira
E
Unità di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, S. Giovanni R, Foggia, Italy. grandone@katamail.com
Vecchione
Gennaro
G
Colaizzo
Donatella
D
Cappucci
Filomena
F
Margaglione
Maurizio
M
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D017202:Myocardial Ischemia / Q000209:etiology*; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood* / Q000150:complications
D017152:Antibodies, Antiphospholipid; D006710:Homocysteine