The precorneal tear film in horses: its importance and disorders.
The precorneal tear film (PTF) is of critical importance in the physiologic and pathologic findings of the cornea. Clinicians should recall that quantitative and qualitative disorders of the PTF can be a cause of corneal diseases as well as a clinical sign of ocular surface diseases. It is also important to consider that some systemic and topical treatments may affect the PTF volume and composition. Not all interactions are known at this time. There is a continued need for basic research into PTF components in healthy and diseased equine eyes, because much remains unknown. Until additional basic information about the biochemical composition and pH of the PTF as well as the interactions between equine corneal pathogens and specific PTF deficits becomes available, it will not be possible to define the cause and effect relations precisely between the various ocular surface diseases and deficiencies,excesses, and imbalances of PTF components. It is quite possible that a number of equine corneal diseases may be manifestations of qualitative PTF disorders.
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, FL 32610, USA. ollivierf@mail.vetmed.ufl.edu
Franck J
FJ
Ollivier
D000818:Animals; D003315:Cornea / Q000473:pathology / Q000502:physiology*; D003316:Corneal Diseases / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology / Q000503:physiopathology*; D006736:Horses; D007765:Lacrimal Apparatus / Q000502:physiology*; D007766:Lacrimal Apparatus Diseases / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary; D013666:Tears / Q000378:metabolism* / Q000502:physiology; D014985:Xerophthalmia / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary