[Cerebral vascular pathology in systemic sclerosis].
Thirty patients with systemic sclerosis (SS), aged 20-55 years, illness duration 1-10 years, were observed. Vasospastic syndrome of different expression predominated in the clinical picture of the disease. Among neurological signs, prevalent were peripheral nervous system lesion--isolated (20% of the cases) or in combination with chronic insufficiency of brain circulation (80%). Vascular pathology was distinctly determined by ophthalmoscopy: angiopathy was found in 42% of the patients, angiospasm--in 25%, angiosclerosis--in 17%. The following types of disorders characterized brain blood flow: distonic (42%), dyscirculatory (33%), normotonic (17%), hypotonic (8%). Besides, 83% of the patients had hemispheric asymmetry of blood flow and difficulties with venous outflow. In some cases, the signs of inner, external and combined hydrocephalia were determined by CT and MRI; more than a half of the patients had dilatation or deformation of brain ventricular system with intracranial hypertension. The data obtained suggest that extra- and intracranial blood flow pathology in SS may, to a large extent, determine both organic brain lesion development in general and the genesis of many symptoms (headaches, vestibular disorders, etc).
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D000328:Adult; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000473:pathology; D006331:Heart Diseases / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000473:pathology; D012595:Scleroderma, Systemic / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed