Trypanosomiasis and trypanotolerance in cattle: a role for congopain?
A Trypanosoma congolense cysteine protease (congopain) elicits a high IgG response in trypanotolerant but not in trypanosusceptible cattle during primary infections. As discussed here by Edith Authié, this observation suggests that congopain, like other parasite cysteine proteases, may play a role in pathogenicity and that more efficient immune responses to congopain may contribute to trypanotolerance.
Authié
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International Laboratory for Research on Animal Diseases, PO Box 30709, Nairobi, Kenya.