Enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester in dispersed aqueous reaction system induced by chiral cyclodextrin.
The enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester to the optically active (S)-ketoprofen was carried out in a dispersed aqueous lipase reaction system induced by the inclusion of chiral cyclodextrins for complexation of the substrate. Hydroxypropyl-beta-cyclodextrin was the most effective chiral selector and disperser giving an enantiomeric excess and conversion yield of 0.99 and 0.49, respectively.
Kim
Sun-Hwa
SH
Department of Genetic Engineering, College of Natural Sciences, Kyungpook National University, Daegu 702-701, South Korea.
Kim
Tae-Kwon
TK
Shin
Gab-Sang
GS
Lee
Kwang-Woo
KW
Shin
Hyun-Dong
HD
Lee
Yong-Hyun
YH
D003505:Cyclodextrins / Q000737:chemistry*; D004789:Enzyme Activation; D004952:Esters; D006868:Hydrolysis; D007660:Ketoprofen / Q000031:analogs & derivatives / Q000737:chemistry*; D008049:Lipase; D012995:Solubility; D013237:Stereoisomerism; D013379:Substrate Specificity; D014867:Water / Q000737:chemistry*
D003505:Cyclodextrins; D004952:Esters; D014867:Water; D007660:Ketoprofen; D008049:Lipase