Healing rate of EMR-induced ulcer in relation to the duration of treatment with omeprazole.
BACKGROUND
Although EMR-induced ulcers heal faster and recur less often than noniatrogenic gastric ulcers, there is no consensus regarding the duration of therapy for these ulcers. This study prospectively evaluated healing of EMR-induced ulcers according to the duration of omeprazole therapy.


METHODS
A total of 69 patients were randomly assigned, after EMR, to treatment with omeprazole (20 mg per day) for 7 days (1-week group) or with omeprazole (20 mg per day) for 28 days (4-week group). Four weeks after EMR, ulcer size and stage were compared with those of the initial EMR-induced ulcer. Each patient kept a daily diary of drugs consumed and ulcer-related symptoms during the 4-week period after EMR.


RESULTS
Thirty-four patients were randomized to the 4-week group, and 26 were randomized to the 1-week group. No significant differences were observed between the two groups at 4 weeks after EMR in terms of ulcer reduction ratio (p=0.29) or stage (p=0.11). In addition, no difference was observed between the two groups with respect to ulcer-related symptoms or use of additional gastric-coating medication (p=0.48).


CONCLUSIONS
For EMR-induced ulcer, treatment with omeprazole for 1 week is equivalent to treatment for 4 weeks. Short-term therapy with omeprazole can be considered for EMR-induced ulcer.
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea.
Sun-Young
SY
Lee
Jae J
JJ
Kim
Jun Haeng
JH
Lee
Young-Ho
YH
Kim
Poong-Lyul
PL
Rhee
Seung Woon
SW
Paik
Jong Chul
JC
Rhee
D000236:Adenoma / Q000601:surgery; D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage*; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000601:surgery; D013276:Stomach Ulcer / Q000188:drug therapy*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D000897:Anti-Ulcer Agents; D009853:Omeprazole