White monkey syndrome in infant baboons (Papio species).
Over 23 months, zinc toxicosis was diagnosed in 35 baboons aged 5-12 months in one galvanized metal and concrete cage complex with conditions that led to excessive exposure to environmental zinc. Clinical signs included reduced pigmentation of hair, skin, and mucous membranes (whiteness), alopecia, dehydration, emaciation, cachexia, dermatitis, diarrhea and, in six cases, severe gangrenous dermatitis of extremities. The syndrome was characterized by pancytopenia, elevated zinc and low copper serum concentrations, low vitamin D and bone-specific alkaline phosphatase levels, and atypical myelomonocytic proliferation of bone marrow. This syndrome emphasizes the importance of proper husbandry and cage design and indicates the potential of infant baboons as a model to study the effects of excessive zinc on development. This is the first report describing the epidemiologic and clinical presentation of zinc toxicosis in infant baboons in captivity.
Department of Comparative Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA.
P A
PA
Frost
G B
GB
Hubbard
M J
MJ
Dammann
C L
CL
Snider
C M
CM
Moore
V L
VL
Hodara
L D
LD
Giavedoni
R
R
Rohwer
M C
MC
Mahaney
T M
TM
Butler
L B
LB
Cummins
T J
TJ
McDonald
P W
PW
Nathanielsz
N E
NE
Schlabritz-Loutsevitch
D000505:Alopecia / Q000209:etiology / Q000662:veterinary; D000704:Analysis of Variance; D000740:Anemia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D003300:Copper / Q000097:blood / Q000172:deficiency; D004268:DNA-Binding Proteins / Q000097:blood; D003872:Dermatitis / Q000209:etiology / Q000662:veterinary; D003967:Diarrhea / Q000209:etiology / Q000662:veterinary; D004781:Environmental Exposure; D005434:Flow Cytometry / Q000662:veterinary; D006799:Housing, Animal; D007621:Karyotyping / Q000662:veterinary; D008027:Light; D008992:Monkey Diseases / Q000473:pathology*; D051757:PAX5 Transcription Factor; D010215:Papio; D010858:Pigmentation / Q000187:drug effects; D011859:Radiography; D011863:Radioimmunoassay / Q000662:veterinary; D013577:Syndrome; D014157:Transcription Factors / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D015032:Zinc / Q000097:blood / Q000506:poisoning*
D004268:DNA-Binding Proteins; D051757:PAX5 Transcription Factor; D014157:Transcription Factors; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D003300:Copper; D015032:Zinc