Cytochrome P450 1A1 polymorphism and childhood leukemia: an analysis of matched pairs case-control genotype data.
The association between the genotypic frequencies of the cytochrome P450 1A1 polymorphism and the risk of childhood leukemia is explored with the data from a matched case-control study. The data are displayed in a 3 x 3 case-control array, and the discordant pair counts are assessed for quasi-independence, homogeneity, and symmetry. This statistical approach is contrasted to the more typical analysis of matched data based on a conditional logistic model and estimated odds ratios. The statistical analysis of 175 matched pairs (part of a large study of potential environmental/genetic influences on the risk of childhood leukemia) showed no evidence of an association between cytochrome P450 1A1 genotype frequencies and case-control status.
School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA. selvin@stat.berkeley.edu
Steve
S
Selvin
D017677:Age Distribution; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D017678:Sex Distribution
D019363:Cytochrome P-450 CYP1A1