Personal view: rationale and proposed algorithms for symptom-based proton pump inhibitor therapy for gastro-oesophageal reflux disease.
Gastro-oesophageal reflux disease and non-erosive reflux disease are chronic, highly prevalent conditions requiring long-term treatment that is both effective and practical. On-demand therapy with a proton pump inhibitor may meet that need. It is becoming a mainstay of long-term treatment because it reduces the risk of over- and under-treatment, is cost-effective and user friendly. Epidemiological and clinical observations speak also in its favour. However, for the anticipated benefits of on-demand therapy to accrue in clinical practice, on-demand treatment algorithms are required. These algorithms must specify the initial evaluation and treatment of candidates, and follow-up protocols for an on-demand strategy. Our group has developed such algorithms, which are presented here.
Bytzer
P
P
Department of Medical Gastroenterology, Glostrup University Hospital, Glostrup, Denmark. peter.bytzer@dadlnet.dk
Blum
A L
AL
D000465:Algorithms; D003362:Cost-Benefit Analysis; D003657:Decision Making; D003663:Decision Trees; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000191:economics; D006801:Humans; D008487:Medical History Taking; D010342:Patient Acceptance of Health Care; D054328:Proton Pump Inhibitors; D012307:Risk Factors; D016896:Treatment Outcome
D054328:Proton Pump Inhibitors