Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population.
We conducted a case-control association study of the monocyte chemoattractant protein-1 (MCP1) gene -2518 polymorphism in 90 patients with major depressive disorder. Genotyping was performed by polymerase chain reaction methods. We found significant differences in genotype and allele frequencies. The present study suggests that this polymorphism may confer a susceptibility to major depressive disorder in the Korean population.
Pae
Chi-Un
CU
Department of Psychiatry, Kangnam St. Mary's Hospital, Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Republic of Korea.
Yu
Hye-Sook
HS
Kim
Tae-Suk
TS
Lee
Chang-Uk
CU
Lee
Soo-Jung
SJ
Jun
Tae-Youn
TY
Lee
Chul
C
Serretti
Alessandro
A
Paik
In-Ho
IH
D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*
D018932:Chemokine CCL2; D017931:DNA Primers