Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures.
Various studies have shown that brain-derived neurotrophic factor (BDNF) increased neuronal excitability. We tested that BDNF might be involved in the etiology of febrile seizures (FSs). A total of 186 Taiwanese children were divided into two groups: (1) FSs (n = 104); (2) normal control subjects (n = 83). A single base pair polymorphism SNP6265 (Val66Met) at position 196 was analyzed. Our findings suggest that the BDNF polymorphisms were not candidate genetic markers.
Departments of Pediatrics, China Medical University Hospital, Taichung, Taiwan.
I-Ching
IC
Chou
Chang-Hai
CH
Tsai
Cheng-Chun
CC
Lee
Sheng-Shing
SS
Lin
Fuu-Jen
FJ
Tsai
D000483:Alleles; D044466:Asian People / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008715:Methionine; D020641:Polymorphism, Single Nucleotide; D003294:Seizures, Febrile / Q000235:genetics*; D013624:Taiwan; D014633:Valine
D019208:Brain-Derived Neurotrophic Factor; D005819:Genetic Markers; D008715:Methionine; D014633:Valine