A convergent, versatile route to two synthetic conjugate anti-toxin malaria vaccines.
The synthesis of two glycosylphosphatidyl inositol (GPI) glycans that constitute the malaria toxin and promising anti-toxin vaccine constructs using a scalable route is described.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. seeberger@org.chem.ethz.ch
Peter H
PH
Seeberger
Regina L
RL
Soucy
Yong-Uk
YU
Kwon
Daniel A
DA
Snyder
Takuya
T
Kanemitsu
D000818:Animals; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis* / Q000737:chemistry; D017780:Malaria Vaccines / Q000138:chemical synthesis* / Q000737:chemistry; D010961:Plasmodium / Q000276:immunology
D017261:Glycosylphosphatidylinositols; D017780:Malaria Vaccines