Free radical processes in the liver of adult and old rats during stress.
We measured the content of free radical lipid peroxidation products, intensity of induced lipid peroxidation, and concentration of carbonylated proteins in the liver of adult (10-12 months) and old rats (22-25 months) subjected to 30-min immobilization. Changes in the intensity of induced lipid peroxidation in homogenates and accumulation of carbonylated proteins in subcellular liver fractions indicate that immobilization stimulates free radical generation in the liver of both adult and old rats. The intensity of this process in old rats surpassed that in adult animals.
Laboratory of Age-Specific Endocrinology and Metabolism, Institute for Child and Adolescent Welfare, Academy of Medical Sciences, Kharkov, Russia.
V V
VV
Davydov
I V
IV
Zakharchenko
V G
VG
Ovsyannikov
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005609:Free Radicals / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism*; D018384:Oxidative Stress; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D005609:Free Radicals; D011506:Proteins