[Penicillium expansum, a resident fungal strain of the orbital complex Mir, producing xanthocillin X and questiomycin A].
It was demonstrated that the fungus Penicillium expansum 2-7, a resident strain of the orbital complex Mir, which became dominating at the end of a long-term space flight, formed biologically active secondary metabolites (antibiotics). Using physicochemical methods, these metabolites were identified as xanthocyllin X and questiomycin A. Time courses of their biosyntheses during growth and development of the producer culture were studied. Addition of zinc to the culture medium affected both the growth of the culture and the biosyntheses of the antibiotics. The concentrations of zinc in the medium, optimum for xanthocyllin X and questiomycin A production, amount to 0.3 and 3.0 mg/l, respectively.
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia.
A G
AG
Kozlovskiĭ
V P
VP
Zhelifonova
T V
TV
Antipova
V M
VM
Adanin
N D
ND
Novikova
E A
EA
Deshevaia
B
B
Schlegel
H M
HM
Dahse
F A
FA
Gollmick
U
U
Grafe
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000378:metabolism*; D002070:Butadienes / Q000737:chemistry / Q000378:metabolism*; D003470:Culture Media; D010078:Oxazines / Q000737:chemistry / Q000378:metabolism*; D010407:Penicillium / Q000254:growth & development / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry / Q000378:metabolism*; D018531:Spacecraft; D013997:Time Factors; D015032:Zinc
D000900:Anti-Bacterial Agents; D002070:Butadienes; D003470:Culture Media; D010078:Oxazines; D010636:Phenols; C493153:xantocillin; C005512:3-aminophenoxazone; D015032:Zinc