Effect of posture on regional gas exchange in pigs.
Although recent high-resolution studies demonstrate the importance of nongravitational determinants for both pulmonary blood flow and ventilation distributions, posture has a clear impact on whole lung gas exchange. Deterioration in arterial oxygenation with repositioning from prone to supine posture is caused by increased heterogeneity in the distribution of ventilation-to-perfusion ratios. This can result from increased heterogeneity in regional blood flow distribution, increased heterogeneity in regional ventilation distribution, decreased correlation between regional blood flow and ventilation, or some combination of the above (Wilson TA and Beck KC, J Appl Physiol 72: 2298-2304, 1992). We hypothesize that, although repositioning from prone to supine has relatively small effects on overall blood flow and ventilation distributions, regional changes are poorly correlated, resulting in regional ventilation-perfusion mismatch and reduction in alveolar oxygen tension. We report ventilation and perfusion distributions in seven anesthetized, mechanically ventilated pigs measured with aerosolized and injected microspheres. Total contributions of pulmonary structure and posture on ventilation and perfusion heterogeneities were quantified by using analysis of variance. Regional gradients of posture-mediated change in ventilation, perfusion, and calculated alveolar oxygen tension were examined in the caudocranial and ventrodorsal directions. We found that pulmonary structure was responsible for 74.0 +/- 4.7% of total ventilation heterogeneity and 63.3 +/- 4.2% of total blood flow heterogeneity. Posture-mediated redistribution was primarily oriented along the caudocranial axis for ventilation and along the ventrodorsal axis for blood flow. These mismatched changes reduced alveolar oxygen tension primarily in the dorsocaudal lung region.
Department of Medicine, Division of Pulmonary & Critical Care Medicine, University of Washington, Seattle, WA 98195-6522, USA. billa@u.washington.edu
William A
WA
Altemeier
Steve
S
McKinney
Melissa
M
Krueger
Robb W
RW
Glenny
D000818:Animals; D003964:Diaphragm / Q000502:physiology; D005260:Female; D006112:Gravitation; D008297:Male; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure; D011187:Posture / Q000502:physiology*; D016684:Prone Position / Q000502:physiology; D011650:Pulmonary Alveoli / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*; D013047:Specific Pathogen-Free Organisms; D016683:Supine Position / Q000502:physiology; D013552:Swine
D010100:Oxygen