Model-based inference of haplotype block variation.
The haplotype block structure of SNP variation in human DNA has been demonstrated by several recent studies. The presence of haplotype blocks can be used to dramatically increase the statistical power of genetic mapping. Several criteria have already been proposed for identifying these blocks, all of which require haplotypes as input. We propose a comprehensive statistical model of haplotype block variation and show how the parameters of this model can be learned from haplotypes and/or unphased genotype data. Using real-world SNP data, we demonstrate that our approach can be used to resolve genotypes into their constituent haplotypes with greater accuracy than previously known methods.
Computer Science Department, Technion, Haifa 32000, Israel. gdg@cs.technion.ac.il
Gideon
G
Greenspan
Dan
D
Geiger
D000465:Algorithms; D001499:Bayes Theorem; D019295:Computational Biology / Q000379:methods* / Q000706:statistics & numerical data; D006239:Haplotypes; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D011995:Recombination, Genetic