P-glycoproteins in nematodes.
The P-glycoprotein (Pgp), a member of a group of integral membrane proteins that contain the ATP-binding cassette, is widely represented in the animal kingdom. A family of Pgp homologues has recently been described in nematodes. Pgps have been implicated in drug resistance in Plasmodium and in other parasitic protozoa, so the interest of porasitologists now focuses on whether or not they are involved in anthelmintic resistance. Their role in normal cellular functions is also discussed in this article by Nick Songster.
Department of Veterinary Pathology, University of Sydney, New South Wales, 2006, Australia.
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Sangster