Neuronal activity in macaque SEF and ACC during performance of tasks involving conflict.
It has been suggested on the basis of previous studies involving functional MRI (fMRI) and single-neuron recording that neurons of the supplementary eye field (SEF) and anterior cingulate cortex (ACC) monitor conflict. To test this idea, we carried out microelectrode recording in monkeys performing a color-conditional eye movement task in which red and green cues instructed leftward and rightward saccades, respectively. In a variant inducing conflict by spatial incompatibility, the cue was presented either at the location of the target (no conflict) or opposite the location of the target (conflict). In a variant inducing conflict by reversal, the foveal cue either remained one color (no conflict) or reversed color after 100 ms (conflict), with the monkey required to follow the instruction conveyed by the second color. In both tasks, conflict was evident in behavioral measures (reduced percent correct and slowed reaction time) and in physiological measures (reduced strength of directional activity among direction-selective neurons). In the SEF, there was a tendency for neurons to fire more strongly on trials involving conflict, but this effect took the form of modulation of task-related activity among direction-selective neurons, not of a pure conflict-monitoring signal. In the ACC, there was no conflict-related enhancement. These results are incompatible with the idea that the SEF and ACC contain populations of neurons specialized for monitoring conflict.
Nakamura
Kae
K
Center for the Neural Basis of Cognition, Mellon Institute, Pittsburgh, PA 15213-2683, USA.
Roesch
Matthew R
MR
Olson
Carl R
CR
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003220:Conflict, Psychological; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D009046:Motor Neurons / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*