Expansion of wild type allele rather than back mutation in pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi.
Mita
Toshihiro
T
Department of International Affairs and Tropical Medicine, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. hiro-tm@research.twmu.ac.jp
Kaneko
Akira
A
Lum
Jeffery K
JK
Zungu
Innocent L
IL
Tsukahara
Takahiro
T
Eto
Hideaki
H
Kobayakawa
Takatoshi
T
Björkman
Anders
A
Tanabe
Kazuyuki
K
D018528:ATP-Binding Cassette Transporters; D019943:Amino Acid Substitution; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D016054:DNA, Protozoan / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D017125:Genes, Protozoan; D005838:Genotype; D006239:Haplotypes; D008295:Malawi; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology*; D026901:Membrane Transport Proteins; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics*; D011157:Population Dynamics; D015800:Protozoan Proteins / Q000235:genetics / Q000502:physiology; D017422:Sequence Analysis, DNA
D018528:ATP-Binding Cassette Transporters; D000962:Antimalarials; D016054:DNA, Protozoan; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C416369:PfCRT protein, Plasmodium falciparum; D015800:Protozoan Proteins; C059987:mdr gene protein, Plasmodium; D002738:Chloroquine; D004262:DNA Restriction Enzymes