Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity.
Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.
Loyola
Luis A
LA
Laboratorio de Productos Naturales, Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Camino a Coloso S/N, Antofagasta, Chile. aloyola@uantof.cl
Bórquez
Jorge
J
Morales
Glauco
G
San-Martín
Aurelio
A
Darias
Jose
J
Flores
Ninoska
N
Giménez
Alberto
A
D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010962:Plasmodium berghei / Q000187:drug effects / Q000254:growth & development
C494164:13,14-dihydroxymulin-11-en-20-oic acid; C494162:20-hydroxymulin-11,13-dienyl acetate; D004224:Diterpenes