Musculoskeletal parameters of muscles crossing the shoulder and elbow and the effect of sarcomere length sample size on estimation of optimal muscle length.
BACKGROUND
Knowledge of musculoskeletal parameters is essential to understanding and modeling a muscle's force generating capability. A study of musculoskeletal parameters was conducted in two parts: (I) Empirical measurement of upper extremity musculoskeletal parameters. (II) Computational bootstrap simulation to examine statistical power of detecting optimal muscle length as a function of sarcomere length sample size and effect size.


METHODS
Parameters were determined with a cadaver model. Sarcomere lengths were measured for 120 samples per muscle using laser diffraction and the mean sarcomere length used to estimate optimal muscle length. A bootstrap computational simulation was conducted to estimate variance in mean sarcomere length as a function of sample size. Statistical power for detecting optimal muscle length as a function of sample size and effect size was then determined.


RESULTS
Parameters are reported in tabular format. Power is 80% at approximately 85, 50, 40 and 25 samples for effect sizes of 0.5, 0.75, 1.0 and 1.5 mm respectively.


CONCLUSIONS
Musculoskeletal parameters for predicting muscle forces can be adequately measured in a cadaver model. Measurement of 40-60 sarcomere lengths per muscle is sufficient to calculate mean sarcomere length for estimating optimal muscle length with power of 80% for an effect size of 0.75-1.0 mm.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-0436, USA.
Joseph
J
Langenderfer
Seth A
SA
Jerabek
Vijay B
VB
Thangamani
John E
JE
Kuhn
Richard E
RE
Hughes
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D002102:Cadaver; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D004550:Elbow / Q000502:physiology; D005260:Female; D006801:Humans; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology*; D012518:Sarcomeres / Q000502:physiology*; D012782:Shoulder / Q000502:physiology