[A new approach to assessment of biological consequences of exposure to low-dose radiation].
A high sensitivity of characteristics of the lipid metabolism in erythrocytes to exposure to low doses of gamma- and X-rays was found; the changes in lipid peroxidation (LPO) of blood components were persistent, which substantially influenced the development of biological consequences of low doses of radiation. The effect of low doses of radiation on the interrelation between the LPO intensity in blood plasma and the lymphocyte DNA structural integrity or the cell-free DNA content in animal blood plasma was found. Different sensitivity of the examined parameters (neither normalization nor linear dependence on a dose rate was found) implies the transition of the LPO regulatory system to another level of functioning due to scale changes of interrelations between the examined parameters under influence of low doses of radiation. These findings make possible to assess biological consequences of radiation factor for animal groups by the scale changes of interrelations between the examined characteristics in blood plasma.
Shishkina
L N
LN
Kushnireva
E V
EV
Smotriaeva
M A
MA
D000818:Animals; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D011834:Radiation Monitoring / Q000379:methods*; D012044:Regression Analysis
D010743:Phospholipids; D004247:DNA