Lipase catalysed Michael addition of secondary amines to acrylonitrile.
A new enzymatic process is described. Different preparations of lipase B from Candida antarctica are able to catalyse Michael-type addition of secondary amines to acrylonitrile. This new reaction widens the applicability of these biocatalysts in organic synthesis.
Torre
Oliver
O
Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, C/Julián Claveria, 8, E-33071 Oviedo, Spain.
Alfonso
Ignacio
I
Gotor
Vicente
V
D000181:Acrylonitrile / Q000737:chemistry* / Q000378:metabolism; D000588:Amines / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism
D000588:Amines; D008049:Lipase; D000181:Acrylonitrile