New approaches to managing congenital diaphragmatic hernia.
A number of new techniques have been studied for managing newborns with congenital diaphragmatic hernia and respiratory insufficiency. Among these have been the techniques of delayed approach to the repair of the diaphragmatic hernia; permissive hypercapnia; nitric oxide and surfactant administration; intratracheal pulmonary ventilation; liquid ventilation; perfluorocarbon-induced lung growth; and lung transplantation. These interventions are at various stages of development and evaluation of effectiveness. All, however, are being explored in the hopes of improving outcome in patients with congenital diaphragmatic hernia who continue to have significant morbidity and mortality in the newborn period.
Ivascu
Felicia A
FA
Department of Surgery, University of Michigan, Ann Arbor 48109-0245, USA.
Hirschl
Ronald B
RB
D015199:Extracorporeal Membrane Oxygenation; D006548:Hernia, Diaphragmatic / Q000628:therapy*; D065630:Hernias, Diaphragmatic, Congenital; D006612:High-Frequency Ventilation; D006801:Humans; D006935:Hypercapnia / Q000473:pathology; D007231:Infant, Newborn; D021061:Liquid Ventilation; D009569:Nitric Oxide / Q000008:administration & dosage; D011663:Pulmonary Surfactants; D012131:Respiratory Insufficiency / Q000151:congenital* / Q000628:therapy*
D011663:Pulmonary Surfactants; D009569:Nitric Oxide