Praziquantel: an urgent and exciting challenge.
The anthelmintic drug praziquantel has proved useful in the treatment of schistosomiasis. The precise mechanism by which praziquantel kills the parasites has yet to be elucidated. Here, John Kusel and colleagues review the current theories on praziquantel action and suggest future avenues for research, which becomes urgent in the light of some reports of drug resistance.
Davidson Building, Division of Biochemistry and Molecular Biology, Institute of Biological and Life Sciences, The University of Glasgow, Glasgow, UK.
C A
CA
Redman
A
A
Robertson
P G
PG
Fallon
J
J
Modha
J R
JR
Kusel
M J
MJ
Doenhoff
R J
RJ
Martin