Enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester in dispersed aqueous reaction system induced by chiral cyclodextrin.
The enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester to the optically active (S)-ketoprofen was carried out in a dispersed aqueous lipase reaction system induced by the inclusion of chiral cyclodextrins for complexation of the substrate. Hydroxypropyl-beta-cyclodextrin was the most effective chiral selector and disperser giving an enantiomeric excess and conversion yield of 0.99 and 0.49, respectively.
Department of Genetic Engineering, College of Natural Sciences, Kyungpook National University, Daegu 702-701, South Korea.
Sun-Hwa
SH
Kim
Tae-Kwon
TK
Kim
Gab-Sang
GS
Shin
Kwang-Woo
KW
Lee
Hyun-Dong
HD
Shin
Yong-Hyun
YH
Lee
D003505:Cyclodextrins / Q000737:chemistry*; D004789:Enzyme Activation; D004952:Esters; D006868:Hydrolysis; D007660:Ketoprofen / Q000031:analogs & derivatives / Q000737:chemistry*; D008049:Lipase; D012995:Solubility; D013237:Stereoisomerism; D013379:Substrate Specificity; D014867:Water / Q000737:chemistry*
D003505:Cyclodextrins; D004952:Esters; D014867:Water; D007660:Ketoprofen; D008049:Lipase