New lignans from the roots of Valeriana prionophylla with antioxidative and vasorelaxant activities.
Two new 7,9':7',9-diepoxylignan glycosides have been isolated from the roots of Valeriana prionophylla. Their structures have been established on the basis of 1D and 2D NMR experiments as prinsepiol-4-O-beta-D-glucopyranoside (1) and fraxiresinol-4'-O-beta-D-glucopyranoside (2). In addition, 8-hydroxypinoresinol-4'-O-beta-d-glucopyranoside (3), 8-hydroxypinoresinol (4), prinsepiol (5), and chlorogenic acid were isolated. Compounds 1, 3, 4, and 5 were evaluated for their antioxidative properties in Trolox equivalent antioxidant activity (TEAC) and chemiluminescence (CL) assays. The same compounds were tested for their vascular activity in rat aorta rings. The aglycones 4 and 5 displayed powerful antioxidant activity; in addition, aglycone 4 showed a higher vasorelaxant activity than compounds 1, 3, and 5.
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy.
Anna Lisa
AL
Piccinelli
Swizly
S
Arana
Armando
A
Caceres
Roberta d'Emmanuele
Rd
di Villa Bianca
Raffaella
R
Sorrentino
Luca
L
Rastrelli
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006166:Guatemala; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014632:Valerian / Q000737:chemistry*; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000975:Antioxidants; D005960:Glucosides; D017705:Lignans; D014665:Vasodilator Agents; C488653:fraxiresinol-4'-O-beta-D-glucopyranoside; C488652:prinsepiol-4-O-beta-D-glucopyranoside