Helicobacter pylori in children and adolescents.
There is now considerable evidence that suggests that the H. pylori organism isa human pathogen. The strong association between H. pylori and gastroduodenal disease is well documented. A number of hypotheses have been suggested for the pathogenic mechanisms of H. pylori-induced gastroduodenal disease, including the presence of bacterial virulence factors, the production of inflammatory mediators, disregulation of acid secretion, and the host immune response. At the present time, treatment with a combination of a proton pump inhibitor and antimicrobial agents continues to be recommended for the treatment of H. pylori-associated peptic ulcer disease.
Department of Pediatrics, Division of Gastroenterology, Rainbow Babies & Children's Hospital, Case Western Reserve University, Hospital 11100 Euclid Avenue, Cleveland, OH 44106, USA. gisela.chelimsky@uhhs.com
Gisela
G
Chelimsky
Samra S
SS
Blanchard
Steven J
SJ
Czinn
D000293:Adolescent; D016497:Adolescent Health Services; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D002648:Child; D002669:Child Welfare; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005756:Gastritis / Q000175:diagnosis* / Q000628:therapy*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000628:therapy*; D016480:Helicobacter pylori; D006801:Humans
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents