A soluble-polymer system for the asymmetric transfer hydrogenation of ketones.
The appropriate combination of methacrylate polymers permits the synthesis of a soluble polymer for use in ruthenium(II)-catalyzed asymmetric transfer hydrogenation reactions. Using a 7:3 copolymer of a poly(ethylene glycol) ester and a hydroxyethyl ester, a derived ruthenium(II)/norephedrine complex catalyses reduction of acetophenone in up to 95% yield and 81% ee.
Bastin
Stephanie
S
Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Eaves
Richard J
RJ
Edwards
Christopher W
CW
Ichihara
Osamu
O
Whittaker
Mark
M
Wills
Martin
M