The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C.
BACKGROUND
A recent report showed that heat shock protein (HSP)-27 expression was related to histological grade and survival of patients with hepatocellular carcinoma (HCC).


OBJECTIVE
The aim of this study was to examine the effect of expression of HSP-27 on clinicopathological variables in Japanese patients with HCC.


METHODS
An immunohistochemical study for HSP-27 was performed on 60 HCC cases using a monoclonal anti-HSP-27 antibody. We divided 60 patients into two groups, patients with a low expression of HSP-27 (n = 34) and those with a high expression of HSP-27 (n = 26). Forty patients tested positive for the hepatitis C virus (HCV) antibody and 20 tested positive for the hepatitis B surface antigen.


RESULTS
There appeared to be no relationship between HSP expression and clinicopathologic factors and no differences were observed between the high expression group and the low expression group. In the hepatitis B virus (HBV) group (n = 20), HSP-27 expression correlated significantly with prognosis, disease-free survival (DFS) and overall survival. High expression was significantly associated with poor prognosis in the HBV group. In contrast, patients with a high expression tended to have a good prognosis in the HCV group (n = 40): DFS and overall survival.


CONCLUSIONS
This study showed the possibility that HSP-27 plays different roles in HBV- and HCV-associated HCCs.
Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan. harimoto@surg2.med.kyushu-u.ac.jp
Norifumi
N
Harimoto
Mitsuo
M
Shimada
Shin-ichi
S
Aishima
Dai
D
Kitagawa
Shinji
S
Itoh
Eiji
E
Tsujita
Shin-ichiro
S
Maehara
Akinobu
A
Taketomi
Shinji
S
Tanaka
Ken
K
Shirabe
Yoshihiko
Y
Maehara
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000401:mortality* / Q000821:virology; D018572:Disease-Free Survival; D005260:Female; D055551:HSP27 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000378:metabolism*; D019694:Hepatitis B, Chronic / Q000378:metabolism / Q000401:mortality*; D019698:Hepatitis C, Chronic / Q000378:metabolism / Q000401:mortality*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000821:virology; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D009363:Neoplasm Proteins / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis
D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins