Molecular biology: what ubiquitin can do for transcription.
Ubiquitin, the peptide 'tag' that targets eukaryotic proteins for degradation by the proteasome, has also been implicated in transcriptional activation. The mechanism of gene activation might include recruitment of a transcriptional elongation factor by ubiquitinated activators.
Herrera
Francisco J
FJ
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, USA.
Triezenberg
Steven J
SJ
D008954:Models, Biological; D042925:Positive Transcriptional Elongation Factor B / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism* / Q000502:physiology
D025801:Ubiquitin; D042925:Positive Transcriptional Elongation Factor B; D012319:RNA Polymerase II