[Synaptic vesicle proteins and psychiatric disorders].
Synaptic vesicle proteins modulate the release of neurotransmitters in the synaptic cleft via regulation of vesicle transport, membrane fusion and exocytosis. Due to their relevance for neural and synaptic plasticity, they represent an important object of molecular psychiatric research. There is increasing evidence that they play a significant role in the pathophysiology of several psychiatric disorders. Furthermore, psychotropic drugs differentially modify the expression of synaptic vesicle proteins; thus, this group of molecules is also of considerable interest from a therapeutic point of view.
Zentralinstitut für Seelische Gesundheit, Mannheim, Deutschland.
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Rapp
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Thome
D001921:Brain / Q000503:physiopathology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D001523:Mental Disorders / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D013572:Synaptic Vesicles / Q000502:physiology*
D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins