Neural correlates of the precedence effect in the inferior colliculus of behaving cats.
Several auditory spatial illusions, collectively called the precedence effect (PE), occur when transient sounds are presented from two different spatial locations but separated in time by an interstimulus delay (ISD). For ISDs in the range of localization dominance (<10 ms), a single fused sound is typically located near the leading source location only, as if the location of the lagging source were suppressed. For longer ISDs, both the leading and lagging sources can be heard and localized, and the shortest ISD where this occurs is called the echo threshold. Previous physiological studies of the extracellular responses of single neurons in the inferior colliculus (IC) of anesthetized cats and unanesthetized rabbits with sounds known to elicit the PE have shown correlates of these phenomena though there were differences in the physiologically measured echo thresholds. Here we recorded in the IC of awake, behaving cats using stimuli that we have shown to evoke behavioral responses that are consistent with the precedence effect. For small ISDs, responses to the lag were reduced or eliminated consistent with psychophysical data showing that sound localization is based on the leading source. At longer ISDs, the responses to the lagging source recovered at ISDs comparable to psychophysically measured echo thresholds. Thus it appears that anesthesia, and not species differences, accounts for the discrepancies in the earlier studies.
Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA. tollin@physiology.wisc.edu
Daniel J
DJ
Tollin
Luis C
LC
Populin
Tom C T
TC
Yin
D018686:Anesthetics, Intravenous / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001522:Behavior, Animal / Q000502:physiology; D002415:Cats; D005260:Female; D007088:Illusions / Q000502:physiology*; D007245:Inferior Colliculi / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013017:Sound Localization / Q000502:physiology*; D013045:Species Specificity
D018686:Anesthetics, Intravenous; D001463:Barbiturates