Experimental validation of an affinity energy distribution calculated with the expectation maximization method.
The difference between the average energies of the high-energy modes of the adsorption energy distributions of (S)-alprenolol and (R)-alprenolol on a chiral stationary phase calculated by the expectation maximization method agree well with the difference between the adsorption energies of these two compounds measured by isothermal titration calorimetry.
Götmar
Gustaf
G
Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996-1600, USA.
Guiochon
Georges
G