[Neonatal lupus: different clinical neonatal expression in siblings].
Neonatal Lupus Syndrome is a rare disease caused by placental passage of maternal autoantibodies. Pathogenesis is partially unknown and many clinical manifestations are possible. We report on newborn siblings who presented with different symptoms of Neonatal Lupus Syndrome. One patient presented with congenital heart block and another with hepatic and haematologic involvement. Cases of Neonatal Lupus among siblings are very rare, because of the high risk of pregnancy in affected women. Various clinical expressions may be explained by a different specificity of Anti-Ro autoantibodies among siblings. The reported cases are commented with regard to recent literature, trying to explain their pathogenesis.
Institut de pédiatrie, division de néonatologie, université catholique du Sacré-Coeur, 8, Largo A. Gemelli, 00168 Rome, Italie. zuppaaa@rm.unicatt.it
A A
AA
Zuppa
A B
AB
Delogu
G
G
De Rosa
D
D
De Luca
F
F
Visintini
F
F
Cota
G
G
Tortorolo
D000022:Abortion, Spontaneous / Q000209:etiology; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006327:Heart Block / Q000151:congenital / Q000175:diagnosis; D006402:Hematologic Diseases / Q000151:congenital; D006801:Humans; D007231:Infant, Newborn; D008107:Liver Diseases / Q000151:congenital; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008431:Maternal-Fetal Exchange; D010375:Pedigree; D018743:Perinatal Care; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011295:Prenatal Care; D012261:Ribonucleoproteins / Q000276:immunology; D000097585:SS-B Antigen; D000099207:SS-A Antigen
D001323:Autoantibodies; D001324:Autoantigens; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen