Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro.
This study was conducted to investigate the anti-proliferative activities of medicinal mushroom Ganoderma lucidum (Rei-shi or Mannentake). We have identified an alcohol extract from the spore of Ganoderma lucidum that inhibits the in vitro proliferation of human umbilical vein endothelial cells and MDA-MB231 human breast cancer cells. Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines in a dose-dependent manner from 2 to 40 micro g/ml. Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities.
Department of Medicine, Center for Human Nutrition, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Qing-Yi
QY
Lu
Maryam R
MR
Sartippour
Mai N
MN
Brooks
Qifeng
Q
Zhang
Mary
M
Hardy
Vay Liang
VL
Go
Frederick P
FP
Li
David
D
Heber
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002845:Chromatography; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D042783:Endothelial Cells / Q000166:cytology; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010936:Plant Extracts / Q000627:therapeutic use*; D020940:Reishi / Q000378:metabolism*; D013172:Spores, Fungal / Q000378:metabolism; D014471:Umbilical Veins / Q000166:cytology
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D000431:Ethanol