Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: case study and review of the literature.
Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain GBM. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic GBM. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.
Armanios
Mary Y
MY
Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA. marmani1@jhmi.edu
Grossman
Stuart A
SA
Yang
Stephen C
SC
White
Barbara
B
Perry
Arie
A
Burger
Peter C
PC
Orens
Jonathan B
JB
D000328:Adult; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects* / Q000473:pathology*; D008297:Male; D014019:Tissue Donors