Hydroxyurea-associated squamous dysplasia.
We report 2 cases of squamous dysplasia associated with long-term hydroxyurea therapy. The association between hydroxyurea and multiple aggressive squamous cell carcinomas, Bowen's disease, and multiple actinic keratoses in sun-exposed areas after a variable latency period has been increasingly reported. On reviewing the literature, 17 cases were identified and are reviewed, with emphasis on possible pathogenetic mechanisms of carcinogenicity. Squamous dysplasia, a precursor state to a more aggressive condition of multiple squamous cell carcinomas in photoexposed areas, should be added to the well-known cutaneous toxicities of hydroxyurea therapy.
Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Carla
C
Sanchez-Palacios
Joan
J
Guitart
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage / Q000009:adverse effects*; D007642:Keratosis / Q000139:chemically induced; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced; D012871:Skin Diseases / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000139:chemically induced; D012883:Skin Ulcer / Q000139:chemically induced
D006918:Hydroxyurea