Triterpenoid total synthesis. Synthesis and absolute configuration of mispyric acid.
The first synthesis of mispyric acid (1), an inhibitor of DNA polymerase beta with a novel triterpene skeleton, was achieved by starting from isoprene (2), geraniol (6) and 1,5-dimethoxy-1,4-cyclohexadiene (14). The absolute configuration of the naturally occurring 1 was determined as 2S,4S.
Department of Biosystems Science, Graduate School of Science and Technology, Kobe University, Rokkodai 1-1, Nada-ku, Kobe 657-8501, Japan.
Yusuke
Y
Imamura
Hirosato
H
Takikawa
Mitsuru
M
Sasaki
Kenji
K
Mori