Gemcitabine-associated scleroderma-like changes of the lower extremities.
Gemcitabine is a nucleosid analog approved for use in the treatment of metastatic urothelial carcinoma of the bladder. We describe an unusual case of scleroderma-like changes of the lower extremities after treatment by gemcitabine for metastatic carcinoma of the bladder. The patient developed initial inflammatory edema (3 kg) restricted to the lower extremities and subsequent scleroderma-like changes after 2 cycles of gemcitabine. Cutaneous biopsy specimen revealed diffuse sclerosis without involvment of the fascia or muscle. Discontinuation of gemcitabine resulted in dramatic removal of the edema, softening of the skin, and partial reversibility of the fibrotic process. This is the first case report of a scleroderma-like reaction associated with gemcitabine. This antineoplastic agent must be added to the very limited number of cytostatic agents capable of giving rise to scleroderma-like features.
Bessis
Didier
D
Department of Dermatology-Phlébology, Centre Hospitalier et Universitaire de Montpellier, Hôpital Saint-Eloi, Montpellier, France. d-bessis@chu-montpellier.fr
Guillot
Bernard
B
Legouffe
Eric
E
Guilhou
Jean-Jacques
JJ
D000082:Acetaminophen / Q000008:administration & dosage; D000639:Amitriptyline / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001706:Biopsy; D001859:Bone Neoplasms / Q000556:secondary; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D002998:Clonazepam / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D020405:Dermis / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage; D004487:Edema / Q000139:chemically induced; D006801:Humans; D007262:Infusions, Intravenous; D007866:Leg; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D045743:Scleroderma, Diffuse / Q000139:chemically induced* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000639:Amitriptyline; D000082:Acetaminophen; D002998:Clonazepam; D014747:Vinblastine; D009020:Morphine; D004317:Doxorubicin; D002945:Cisplatin; D008727:Methotrexate; D000093542:Gemcitabine