Minimum effective dose of dexamethasone after tonsillectomy.
BACKGROUND
The minimum effective dose of dexamethasone in conjunction with 50 microg x kg(-1) ondansetron was evaluated in the treatment for vomiting after elective tonsillectomy or adenotonsillectomy.


METHODS
A total of 102 healthy children between 2 and 12 years of age participated in this prospective, randomized, double-blind study. A single intravenous (i.v.) dose of dexamethasone (50, 100, 150 microg x kg(-1), maximum dose 8 mg) with ondansetron (50 microg x kg(-1)) was administered just before the end of surgery. Equal volumes of normal saline were given to the control group. General anaesthesia was induced and maintained by inhalation of N2O/O2 and sevoflurane. All other preoperative and postoperative medications (including a supplementary dose of antiemetics if necessary), anaesthesia and surgical techniques were standardized.


RESULTS
No significant differences were observed between groups in postoperative vomiting on the day of surgery and the next day, or in the need for postoperative pain medication and supplementary doses of antiemetics (P > 0.05).


CONCLUSIONS
These results indicate that surgical technique and anaesthetic management used in this study could be the cause of the lower incidence of nausea and vomiting. Assessment of nausea and vomiting in a prospective study with larger groups of patients may reflect different results.
Department of Anaesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Varol
V
Celiker
Nalan
N
Celebi
Ozgür
O
Canbay
Elif
E
Başgül
Ulkü
U
Aypar
D000704:Analysis of Variance; D000768:Anesthesia, General / Q000379:methods; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D017294:Ondansetron / Q000627:therapeutic use; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors; D014068:Tonsillectomy / Q000379:methods*
D014151:Anti-Anxiety Agents; D000893:Anti-Inflammatory Agents; D012965:Sodium Chloride; D017294:Ondansetron; D003907:Dexamethasone