C-reactive protein and white blood cell count increases in the first 24 hours after acute stroke.
Levels of C-reactive protein (CRP) and white blood cell count (WBC) in acute stroke may reflect the stroke lesion itself or pre-existing factors such as infections, smoking or atherosclerosis. The aim of this study was to investigate the relation between CRP and WBC levels and time from onset of stroke, stroke severity and outcome.


METHODS
The analyses were based on 719 patients in whom WBC test material was obtained within 9 h of stroke onset and CRP test material within 24 h of stroke onset. Stroke severity was assessed by the Scandinavian Stroke Scale Score on admission and outcome by death 7 days, 3 months and 1 year after symptom onset as well as modified Rankin Scale 3 months after stroke onset.


RESULTS
CRP and WBC levels correlated significantly with time from symptom onset as well as with stroke severity and outcome. Levels of CRP and WBC were higher in later determinations in severe stroke. In multivariate logistic regression analysis, CRP(+10 mg/l) was independently related to 1-year mortality (OR 1.1, 95% CI 1.02-1.2).


CONCLUSIONS
Levels of WBC and CRP increase within the first 24 h in patients with severe stroke. CRP but not WBC is related to long-term mortality possibly by reflecting the vascular risk profile.
Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. hc04@bbh.hosp.dk
Hanne
H
Christensen
Gudrun
G
Boysen
D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D016015:Logistic Models; D015999:Multivariate Analysis; D011446:Prospective Studies; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000503:physiopathology; D016019:Survival Analysis; D013997:Time Factors
D002097:C-Reactive Protein