Unusual compulsive motor activity during treatment with clothiapine in a mentally retarded adolescent.
Atypical antipsychotic agents, specifically those with a high hyposerotonergic activity such as clozapine and clothiapine, have been associated with de novo obsessive-compulsive symptoms. We report the case of a 16-year-old adolescent male with severe mental impairment and disruptive behaviour who developed a compulsive head and body turning disorder on clothiapine. Such a symptom had to be distinguished from epileptic partial seizures; it promptly disappeared with the drug discontinuation.
Clinic of Child Neuropsychiatry, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. giangennaro.coppola@unina2.it
Giangennaro
G
Coppola
Eduardo
E
Morelli
Carmela
C
Bravaccio
Rosario
R
Federico
Antonella
A
Gritti
D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000188:drug therapy* / Q000209:etiology; D003192:Compulsive Behavior / Q000139:chemically induced* / Q000503:physiopathology; D003937:Diagnosis, Differential; D003987:Dibenzothiazepines / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D020938:Epilepsy, Partial, Motor / Q000175:diagnosis; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced* / Q000503:physiopathology; D008607:Intellectual Disability / Q000150:complications* / Q000523:psychology; D008297:Male
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D006220:Haloperidol; C084602:clothiapine