The potential for Toll-like receptors to collaborate with other innate immune receptors.
Cells of the innate immune system express a large repertoire of germ-line encoded cell-surface glycoprotein receptors including Toll-like receptors (TLRs). TLRs recognize conserved motifs on microbes and induce inflammatory signals. Evidence suggests that individual members of the TLR family or other non-TLR surface antigens either physically or functionally interact with each other and cumulative effects of these interactions instruct the nature and outcome of the immune response to a particular pathogen.
Mukhopadhyay
Subhankar
S
Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.
Herre
Jurgen
J
Brown
Gordon D
GD
Gordon
Siamon
S
D006801:Humans; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017452:Receptors, IgG / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors; D000099181:Dectin-1
D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D018047:Receptors, Purinergic P1; D051193:Toll-Like Receptors; D000099181:Dectin-1