The Mortimer M. Bortin Lecture: to destroy by the reaction of immunity: the search for separation of graft-versus-leukemia and graft-versus-host.
The graft-versus-leukemia effect of allogeneic blood or marrow transplantation is a dramatic example of the power of the immune system to eradicate malignant disease. In this personal essay, adapted from the inaugural Mortimer M. Bortin Lecture presented at the 2004 Tandem BMT Meetings, the author recounts early efforts by Bortin and others to manipulate the graft-versus-leukemia effect and separate it from the potentially fatal complications of graft-versus-host disease.
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. rtruitt@mcw.edu
Robert L
RL
Truitt
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000628:therapy; D006087:Graft vs Host Reaction; D020544:Graft vs Leukemia Effect; D020350:Graft vs Tumor Effect / Q000276:immunology; D006801:Humans; D016219:Immunotherapy, Adoptive; D007938:Leukemia / Q000628:therapy; D051379:Mice; D008806:Mice, Inbred AKR; D018448:Models, Immunological; D036102:Peripheral Blood Stem Cell Transplantation; D011832:Radiation Injuries / Q000150:complications / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014181:Transplantation Immunology / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology