Spliced leader RNA trans-splicing in metazoa.
Spliced leader trans-splicing is a form of RNA processing originally described and studied in parasitic kinetoplastida. This mechanism of gene expression also occurs in parasitic and free-living metazoa. In this review, Dick Davis describes current knowledge of the distribution, substrates, specificity and functional significance of trans-splicing in metazoa.
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Department of Biological Sciences, Fordham University, New York Bronx, NY 10458, USA. rdavis@murray.fordham.edu