Effects of norepinephrine depletion in rats during cerebral post-ischemic reperfusion.
The present paper reports the effects of norepinephrine depletion in rats, after treatment with N-(2-chloroethyl)-N-ethyl 2-bromobenzylamine (DSP-4) neurotoxin, on partial cerebral ischemia and reperfusion. Histological observations made under experimental conditions of noradrenergic (NA)-depletion demonstrated that neuronal lesions were not exacerbated; in fact, in DSP-4-treated ischemic animals, a minor number of neurons appeared damaged. Our results suggest that neuronal recovery after post-ischemic reperfusion is not affected by NA-depletion. DSP-4 neurotoxin does not induce 5-hydroxy-triptamine (5-HT) depletion.
Department of Anatomy, Diagnostic Pathology, Legal Medicine and Public Health (G. Ingrassia 1510-1589 Anatomist), Faculty of Medicine, University of Catania, Via S. Sofia 87 (Comparto 10), 95123 Catania, Italy.
G
G
Martinez
C
C
Di Giacomo
V
V
Sorrenti
M L
ML
Carnazza
V
V
Bisceglie
A
A
Vanella
D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D001930:Brain Injuries / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D004396:Coloring Agents; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000473:pathology; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology*; D012701:Serotonin / Q000378:metabolism; D016622:Silver Staining
D001596:Benzylamines; D004396:Coloring Agents; D012701:Serotonin; D019344:Lactic Acid; C012102:DSP 4; D009638:Norepinephrine