Consensus opinion from the antibody working group on the diagnosis, reporting, and risk assessment for antibody-mediated rejection and desensitization protocols.
During the past few decades, much of the experimental and clinical effort in solid-organ transplantation has been directed toward ameliorating or abrogating T-cell-mediated responses. As a result, universally understood and accepted nomenclature and diagnostic criteria have evolved. Humoral immunity in transplantation has yet to undergo a similar renaissance. Readers of transplant journals regularly find it difficult and often impossible to interpret data on the diagnosis and management of antibody-mediated rejection. The Antibody Working Group was assembled in an attempt to provide guidelines for the standardization of nomenclature, diagnostic criteria, reporting, antibody profiling, and risk assessment.
Department of Surgery, Division of Transplantation, Johns Hopkins University School of Medicine, Ross 765/720 Rutland Avenue, Baltimore, MD 21205, USA.
Robert A
RA
Montgomery
Mark A
MA
Hardy
Stanley C
SC
Jordan
Lorraine C
LC
Racusen
Lloyd E
LE
Ratner
Dolly B
DB
Tyan
Andrea A
AA
Zachary
D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007518:Isoantibodies / Q000276:immunology*; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*; D019172:Transplantation Conditioning / Q000379:methods
D007518:Isoantibodies