The chicken genome and the developmental biologist.
Recently the initial draft sequence of the chicken genome was released. The reasons for sequencing the chicken were to boost research and applications in agriculture and medicine, through its use as a model of vertebrate development. In addition, the sequence of the chicken would provide an important anchor species in the phylogenetic study of genome evolution. The chicken genome project has its roots in a decade of map building by genetic and physical mapping methods. Chicken genetic markers for map building have generally depended on labour intensive screening procedures. In recent years this has all changed with the availability of over 450,000 EST sequences, a draft sequence of the entire chicken genome and a map of over 1 million SNPs. Clearly, the future for the chicken genome and developmental biology is an exciting one. Through the integration of these resources, it will be possible to solve challenging scientific questions exploiting the power of a chicken model. In this paper we review progress in chicken genomics and discuss how the new tools and information on the chicken genome can help the developmental biologists now and in the future.
Department of Genomics and Bioinformatics, Roslin Institute (Edinburgh), Midlothian EH25 9PS, UK. dave.burt@bbsrc.ac.uk
David W
DW
Burt
D000818:Animals; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics*; D018076:DNA, Complementary; D015509:Developmental Biology; D019143:Evolution, Molecular; D020224:Expressed Sequence Tags; D016678:Genome; D007621:Karyotyping
D018076:DNA, Complementary