Diterpenes from the brown algae Dictyota dichotoma and Dictyota linearis.
Nineteen secondary metabolites of the brown alga Dictyota dichotoma (Huds.) Lam. and fifteen metabolites of the brown alga D. linearis (Ag.) Grev. were isolated and their chemical structures were elucidated on the basis of their NMR and mass spectral data. The diterpenes isopachydictyolal (1) from D. dichotoma and 4alpha-acetyldictyodial (2) from D. linearis are new natural products. The antiviral activity of metabolites isolated in adequate amounts was evaluated in laboratory assays against Herpes simplex virus I (HSV I) and Poliomyelitis Virus I, using Vero cells as hosts.
Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Athens, Panepistimioupolis Zografou, 157 71 Athens, Greece.
Panayiota
P
Siamopoulou
Antonis
A
Bimplakis
Dimitra
D
Iliopoulou
Constantinos
C
Vagias
Paul
P
Cos
Dirk
D
Vanden Berghe
Vassilios
V
Roussis
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*
D000998:Antiviral Agents; D004224:Diterpenes