[Influence of Shenshuai Capsule on renal tissue apoptosis of rats with chronic renal failure].
OBJECTIVE
To explore the influence of Shenshuai Capsule on renal tissue apoptosis of Wistar rats with chronic renal failure.


METHODS
Wistar rats were fed with adenine to establish chronic renal failure model, and then they were divided into three groups separately fed with Shenshuai capsule (high or low dosage) and Niaoduqing. RIA, immunohistochemical method and electron microscopy were used.


RESULTS
The parameters of renal function between the treatment group (high dosage) and the Niaoduqing group were significantly different respectively. Shenshuai capsule could inhibit tubular epicyte apoptosis and Fas genetic expression, and improve Bcl-2 genetic expression.


CONCLUSIONS
Shenshuai capsule could inhibit epicyte apoptosis, and adjust Fas genetic expression. Bcl-2 genetic expression indicated that this may be one of the mechanism to postpone the renal failure by Shunshuai capsule.
No. 465 Hospital of PLA, Jilin 132013.
Shaohua
S
Wang
Jing
J
Chen
Qiang
Q
Fu
D000225:Adenine; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D019014:fas Receptor / Q000378:metabolism
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor; D000225:Adenine