Granular cell tumor of colon: report of a case and review of literature.
Granular cell tumor (GCT) is uncommon in the colon and rectum. Here we report a case of GCT in the transverse colon. A 48-year-old male patient underwent a screening colonoscopy. A yellowish sessile lesion, about 4 mm in diameter, was found in the transverse colon. An endoscopic snare resection was performed without complication. Histological examination revealed the tumor consisted of plump neoplastic cells with abundant granular eosinophilic cytoplasm containing acidophilic periodic acid Schiff-positive, diastase-resistant granules. Immunohistochemical analysis showed the tumor cells expressed S-100 protein and neuron-specific enolase. Thus, the resected tumor was diagnosed as a GCT. Since GCTs are usually benign, endoscopic resection constitutes an easy and safe treatment. Colonoscopists should consider the possibility of GCT in the differential diagnosis of submucosal tumors of the colon.
Sohn
Dae-Kyung
DK
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang, Gyeonggi 411-769, Korea.
Choi
Hyo-Seong
HS
Chang
Yeon-Soo
YS
Huh
Jin-Myeong
JM
Kim
Dae-Hyun
DH
Kim
Dae-Yong
DY
Kim
Young-Hoon
YH
Chang
Hee-Jin
HJ
Jung
Kyung-Hae
KH
Jeong
Seung-Yong
SY
D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged