Second-generation antimalarial endoperoxides.
Artemisinin, derived from a Chinese herbal remedy, is a potent peroxide-containing antimalarial. New types of peroxides, derived from this structure, as well as other naturally occurring antimalarial peroxides, have been synthesized and found to have potent antimalarial activities. Studies on the activities, modes of action, and toxicities of these compounds are discussed here by Steven Meshnick and colleagues.
Meshnick
S R
SR
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. Meshnick@umich.edu
Jefford
C W
CW
Posner
G H
GH
Avery
M A
MA
Peters
W
W