Symmetry, T cells and neurogenic arthritis.
Symmetry in clinical disease occurs more commonly than expected by chance and is unexplained. In this paper we focus on symmetry in arthritis and describe the neurogenic hypothesis. Neuropeptides are anatomically relevant to systemic arthritis and have been shown to have modulating effects on both the immune and circulatory systems. Neural networks project bilaterally and are involved in the development and propagation of inflammatory disease. These putative pathological neuro-feedback loops may derive from the existence of biologically protective symmetrical mechanisms.
Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, BA1 IRL, UK.
N G
NG
Shenker
D R
DR
Blake
C S
CS
McCabe
R
R
Haigh
P I
PI
Mapp
D001168:Arthritis / Q000276:immunology* / Q000503:physiopathology; D001177:Arthropathy, Neurogenic / Q000276:immunology* / Q000503:physiopathology; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology; D006801:Humans; D009415:Nerve Net / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000503:physiopathology; D013373:Substance P / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D013373:Substance P; D015740:Calcitonin Gene-Related Peptide