Overview on the mechanisms of drug-induced liver cell death.
Drug-induced hepatotoxicity is a significant and still unresolved clinical problem. The limitation in current knowledge regarding mechanisms of hepatic toxicity renders most of the preclinical review process failing and most of drug-induced hepatic injury remains unpredictable. Current knowledge on the mechanisms of drug-induced liver cell death is reviewed here. The intervention of both intra- and extracellular factors in determining the appearance of drug-induced cell apoptosis or necrosis is also discussed. Finally, the role of both mitochondria and non parenchymal cells are reviewed with respect to approaches useful to manage drug-induced liver injury.
Grattagliano
Ignazio
I
Department of Internal Medicine and Public Medicine (DIMIMP), University Medical School, Bari, Italy. igratta@tin.it
Portincasa
Piero
P
Palmieri
Vincenzo O
VO
Palasciano
Giuseppe
G
D017209:Apoptosis / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D008930:Mitochondria, Liver / Q000473:pathology; D009336:Necrosis