Low fasting low high-density lipoprotein and postprandial lipemia.
BACKGROUND
Low levels of high density lipoprotein (HDL) cholesterol and disturbed postprandial lipemia are associated with coronary heart disease. In the present study, we evaluated the variation of triglyceride (TG) postprandially in respect to serum HDL cholesterol levels.


RESULTS
Fifty two Greek men were divided into 2 main groups: a) the low HDL group (HDL < 40 mg/dl), and b) the control group. Both groups were further matched according to fasting TG (matched-low HDL, and matched-control groups). The fasting TG concentrations were higher in the low HDL group compared to controls (p = 0.002). The low HDL group had significantly higher TG at 4, 6 and 8 h postprandially compared to the controls (p = 0.006, p = 0.002, and p < 0.001, respectively). The matched-low HDL group revealed higher TG only at 8 h postprandially (p = 0.017) compared to the matched-control group. ROC analysis showed that fasting TG > or = 121 mg/dl have 100% sensitivity and 81% specificity for an abnormal TG response (auc = 0.962, p < 0.001).


CONCLUSIONS
The delayed TG clearance postprandially seems to result in low HDL cholesterol even in subjects with low fasting TG. The fasting TG > 121 mg/dl are predictable for abnormal response to fatty meal.
Kolovou
Genovefa D
GD
1st Cardiology Department, Onassis Cardiac Surgery Center, 17674, Athens, Greece. genkolovou@mail.gr
Anagnostopoulou
Katherine K
KK
Pilatis
Nektarios
N
Kafaltis
Nikolaos
N
Sorodila
Konstandina
K
Psarros
Eleftherios
E
Cokkinos
Dennis V
DV