Methylprednisolone sodium succinate in pediatric parenteral nutrition: influence of vehicle injection.
Many drugs can be administered in parenteral nutrient mixtures, but no work on the delivery of corticoids by such means is reported. We studied the influence of pediatric parenteral nutrient mixtures on the kinetic parameters of the corticoid methylprednisolone injected in an intravenous bolus in rabbits as its sodium succinate ester. Four groups of six male New Zealand rabbits were used. After extraction, the plasma drug concentrations were measured by high performance liquid chromatography. The distribution volume of the ester and the clearance rates of the two entities (ester and methylprednisolone) were lowered in the presence of a lipid emulsion. The description of these pharmacokinetic parameters provides a basis for a preclinical study of 24h administration of methylprednisolone in a parenteral nutrient mixture.
Clinical and Biotecnological Pharmacy Laboratory, Faculté de Médecine-Pharmacie, 28, place Henri-Dunant, 63003 Clermont-Ferrand cédex, France.
Christophe
C
Gellis
Valérie
V
Sautou-Miranda
Jean-François
JF
Jarrige
Anne
A
Grand-Boyer
Nathalie
N
Bleyzac
Jean
J
Chopineau
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004344:Drug Incompatibility; D004355:Drug Stability; D005938:Glucocorticoids / Q000493:pharmacokinetics*; D007263:Infusions, Parenteral / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate; D008776:Methylprednisolone Hemisuccinate / Q000493:pharmacokinetics*; D010288:Parenteral Nutrition / Q000379:methods; D011817:Rabbits
D004338:Drug Combinations; D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate