Nuclear factor kappa B--molecular biomedicine: the next generation.
Nuclear factor kappa B (NFkappaB) as a transcription factor plays an important integrating role in the intracellular regulation of immune response, inflammation and cell cycle regulation. Nouvelle insights into the structure and regulation of activation of NFkappaB have brought a detailed picture of the function of this transcription factor. In this review the findings of interactions of NFkappaB with its inhibitors, tumour necrosis factor alpha and glucocorticoids are presented. The results from the latest in vivo studies show the capability of specific NFkappaB inhibitors in the clinical use. This article summarizes the most important facts regarding NFkappaB participation in the pathogenesis of diseases and its potential as a target of pharmacological agents.
Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia. petercelec@hotmail.com
Peter
P
Celec
D000818:Animals; D005938:Glucocorticoids / Q000502:physiology; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D005938:Glucocorticoids; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha