Expansion of wild type allele rather than back mutation in pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi.
Department of International Affairs and Tropical Medicine, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. hiro-tm@research.twmu.ac.jp
Toshihiro
T
Mita
Akira
A
Kaneko
Jeffery K
JK
Lum
Innocent L
IL
Zungu
Takahiro
T
Tsukahara
Hideaki
H
Eto
Takatoshi
T
Kobayakawa
Anders
A
Björkman
Kazuyuki
K
Tanabe
D018528:ATP-Binding Cassette Transporters; D019943:Amino Acid Substitution; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D016054:DNA, Protozoan / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D017125:Genes, Protozoan; D005838:Genotype; D006239:Haplotypes; D008295:Malawi; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology*; D026901:Membrane Transport Proteins; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics*; D011157:Population Dynamics; D015800:Protozoan Proteins / Q000235:genetics / Q000502:physiology; D017422:Sequence Analysis, DNA
D018528:ATP-Binding Cassette Transporters; D000962:Antimalarials; D016054:DNA, Protozoan; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C416369:PfCRT protein, Plasmodium falciparum; D015800:Protozoan Proteins; C059987:mdr gene protein, Plasmodium; D002738:Chloroquine; D004262:DNA Restriction Enzymes