Characterization of adenylate cyclase-hemolysin gene duplication in a Bordetella pertussis isolate.
We describe a clinical isolate of Bordetella pertussis, the agent responsible for whooping cough, composed of at least two clones harboring one or two copies of the cya locus encoding one of the major toxins, adenylate cyclase-hemolysin. No difference was observed between the two clones in murine and cellular models, probably due to the high instability of the cya locus duplication.
Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
Karine
K
Dalet
Christian
C
Weber
Laurent
L
Guillemot
Elisabeth
E
Njamkepo
Nicole
N
Guiso
D037361:Adenylate Cyclase Toxin / Q000235:genetics* / Q000633:toxicity*; D000818:Animals; D001886:Bordetella pertussis / Q000235:genetics / Q000472:pathogenicity*; D002460:Cell Line; D004195:Disease Models, Animal; D020440:Gene Duplication; D006801:Humans; D008264:Macrophages; D051379:Mice; D014132:Trachea / Q000382:microbiology; D014917:Whooping Cough / Q000382:microbiology*
D037361:Adenylate Cyclase Toxin