Augmented inhibition of Candida albicans growth by murine neutrophils in the presence of a tryptophan metabolite, picolinic acid.
The effects of picolinic acid (PLA), a product of tryptophan catabolism, on anti- Candida activity of neutrophils were studied. Casein-induced peritoneal neutrophils of C3H/He mice partially inhibited mycelial growth of Candida albicans when cultured with C. albicans for 16 h in vitro. The growth inhibition of Candida was augmented by a combination of neutrophils and more than 4 mM picolinic acid. Especially in the presence of 200 U/ml murine interferon-gamma (IFN-gamma), 2 mM picolinic acid augmented the anti- Candida activity of neutrophils. The physiological significance of the augmenting effects of picolinic acid is discussed.
Teikyo University Institute of Medical Mycology, 359 Ohtsuka, Hachioji, 192-0395, Tokyo, Japan. sabe@main.teikyo-u.ac.jp
Shigeru
S
Abe
Weimin
W
Hu
Hiroko
H
Ishibashi
Keiji
K
Hasumi
Hideyo
H
Yamaguchi
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D004357:Drug Synergism; D007371:Interferon-gamma / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D009504:Neutrophils / Q000382:microbiology*; D010848:Picolinic Acids / Q000008:administration & dosage / Q000494:pharmacology*
D000935:Antifungal Agents; D010848:Picolinic Acids; D007371:Interferon-gamma; C030614:picolinic acid