Milestones of neuronal development in the adult hippocampus.
Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.
Kempermann
Gerd
G
VolkswagenStiftung Research Group, Department of Experimental Neurology, Charité University Medicine Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany. gerd.kempermann@mdc-berlin.de
Jessberger
Sebastian
S
Steiner
Barbara
B
Kronenberg
Golo
G
D000328:Adult; D000818:Animals; D015415:Biomarkers; D064032:Calbindin 2; D002455:Cell Division; D006624:Hippocampus / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008959:Models, Neurological; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013234:Stem Cells / Q000145:classification / Q000166:cytology* / Q000378:metabolism
D015415:Biomarkers; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G