[Vulvar carcinoma. Diagnosis and therapy].
Vulvar cancer is a rare entity. It appears mostly in older women aged 70-79 years with a slow tendency to younger age. More than 90% of the tumors show a squamous differentiation. The correspondent preneoplasia is VIN 3. This lesion occurs in women mostly younger than 35 years. Experts assume vulvar cancer to appear in two different types:HPV-induced type in younger women and non-HPV-dependent type in older women. The preneoplasia VIN 3 already should be treated by resection or destruction. Invasive carcinomas stage I or II can be treated by wide local excision. The inguinofemoral lymph nodes should be resected if invasion exceeds 1 mm in depth. In larger primary tumors, vulvectomy with bilateral inguinofemoral node dissection is indicated. In advanced tumor stages, multimodal concepts are applied: primary radiotherapy or radiochemotherapy may precede a salvage operation.
Schnürch
H G
HG
Arbeitsgemeinschaft Gynäkologische Onkologie, Frauenklinik, Lukaskrankenhaus, Neuss. HGSchnuerch@lukasneuss.de
D000368:Aged; D001706:Biopsy; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy