Immune status: normal expression of MHC class I in the placenta and what is expected in clones.
Major histocompatibility complex (MHC) class I genes are highly polymorphic, widely expressed genes that play a vital role in immune responses. Because of their involvement in tissue transplant rejection there has been much interest in their expression during pregnancy. This review examines the evidence for their role in livestock reproduction, and speculates that the process of creating clones may modify their expression with deleterious results.
Ellis
Shirley A
SA
Institute for Animal Health, Compton, Newbury, United Kingdom. shirley.ellis@bbsrc.ac.uk
D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D019976:Cloning, Organism / Q000662:veterinary*; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology / Q000378:metabolism / Q000662:veterinary; D012098:Reproduction / Q000276:immunology*
D015395:Histocompatibility Antigens Class I