Chromosome condensation: DNA compaction in real time.
Mitotic chromosomes must be organised into a highly ordered and compacted form to allow proper segregation of DNA during each round of cell division. Two new studies report observations of DNA compaction by eukaryotic and bacterial condensin molecules in real time using magnetic and optical trapping micromanipulation techniques.
Division of Gene Regulation and Expression, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
Iain M
IM
Porter
Guennadi A
GA
Khoudoli
Jason R
JR
Swedlow
D000251:Adenosine Triphosphatases / Q000378:metabolism / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology; D002875:Chromosomes / Q000378:metabolism / Q000502:physiology*; D004247:DNA / Q000378:metabolism / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D008846:Micromanipulation; D008863:Microspheres; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D046912:Multiprotein Complexes; D009690:Nucleic Acid Conformation
D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; C108312:condensin complexes; D000255:Adenosine Triphosphate; D004247:DNA; D000251:Adenosine Triphosphatases