A direct, efficient method for the preparation of n6-protected 15n-labeled adenosines.
N6-Protected adenosines have been prepared from inosines by activation of the C6 position and Pd-catalyzed coupling with amides. An efficient route to [6-15NH2]-N6-benzoyladenosine and [1-15N,6-15NH2]-N6-benzoyladenosine has been achieved.
Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, 08028 Barcelona, Spain.
Montserrat
M
Terrazas
Xavier
X
Ariza
Jaume
J
Farràs
José M
JM
Guisado-Yang
Jaume
J
Vilarrasa
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D007288:Inosine / Q000737:chemistry*; D009587:Nitrogen Isotopes; D010165:Palladium / Q000737:chemistry*
D000577:Amides; D007202:Indicators and Reagents; D009587:Nitrogen Isotopes; D007288:Inosine; D010165:Palladium; D000241:Adenosine