Vascular endothelial growth factor in esophageal cancer.
Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis of many solid malignancies. The influence of angiogenesis and VEGF expression on progression and recurrence of esophageal cancer has been investigated over the last years. This article reviews the prognostic significance of VEGF expression, microvessel density (MVD), and lymphangiogenic factors in squamous cell carcinoma (SCC), Barrett's dysplasia, and adenocarcinoma (AC) of the esophagus, their predictive value for treatment response to chemo-radiotherapy and new anti-angiogenic treatment strategies.
Department of Surgery, Klinikum Grosshadern, Ludwig-Maximilian-University, Munich, Germany. axelkleespies@aol.com
Axel
A
Kleespies
Markus
M
Guba
Karl-Walter
KW
Jauch
Christiane J
CJ
Bruns
D000230:Adenocarcinoma / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001471:Barrett Esophagus / Q000378:metabolism; D000068258:Bevacizumab; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D042583:Lymphangiogenesis; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D000078183:Oxindoles; D011379:Prognosis; D011422:Propionates; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011758:Pyrroles / Q000627:therapeutic use; D016337:RNA, Catalytic / Q000627:therapeutic use; D012333:RNA, Messenger / Q000096:biosynthesis; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
C121301:Angiozyme; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007211:Indoles; D000078183:Oxindoles; D011422:Propionates; D011758:Pyrroles; D016337:RNA, Catalytic; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab; C412603:orantinib; D011505:Protein-Tyrosine Kinases