[Successful treatment of 5-FU intraarterial infusion on the third postoperative day for a patient with multiple liver metastases from colon cancer and high risk of liver failure].
A 68-year-old man with multiple liver metastases from stage 4 advanced descending colon cancer who underwent partial resection of the colon and simultaneous catheter insertion into the gastroduodenal artery for arterial infusion chemotherapy. On postoperative day 3, the multiple liver metastases had enlarged so rapidly that there was high risk of liver failure. Intraarterial infusion of 5-FU 600 mg/m2 (1,000 mg/body) for 6 hours weekly and intravenous administration of methylpredonisolone 125 mg were started for emergency chemotherapy on the third postoperative day. Only 1 course was sufficient for the patient be rid of oncologic emergencies and liver failure. After 3 courses, liver metastases showed significant reduction.
Dept. of Surgery, Misawa Municipal Hospital.
Tatsuya
T
Mori
Masaki
M
Munakata
Masaharu
M
Kasai
Tsuyoshi
T
Nozaki
Setsuko
S
Kawamura
Noriko
N
Sawamura
Hiroto
H
Hiraga
Yuh
Y
Sakata
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage; D003082:Colectomy; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D017093:Liver Failure; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D011184:Postoperative Period; D012306:Risk
D000964:Antimetabolites, Antineoplastic; D001562:Benzimidazoles; C483319:methylproamine; D005472:Fluorouracil