Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major.
The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.
Santiago
Helton da Costa
HC
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
Oliveira
Carolina Ferreira
CF
Santiago
Luciana
L
Ferraz
Fernanda Oliveira
FO
de Souza
Daniele da Glória
D G
de-Freitas
Luiz Antônio Rodrigues
LA
Afonso
Luís Carlos Crocco
LC
Teixeira
Mauro Martins
MM
Gazzinelli
Ricardo Tostes
RT
Vieira
Leda Quercia
LQ
D000818:Animals; D018946:Chemokine CCL5 / Q000378:metabolism*; D018320:Leishmania major; D016773:Leishmaniasis, Cutaneous / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
D018946:Chemokine CCL5