Anti-diabetic activity of Eugenia jambolana seed kernels on streptozotocin-induced diabetic rats.
The present study evaluated the hypoglycemic activity of different parts of Eugenia jambolana seeds such as whole seed, kernel, and seed coat on streptozotocin-induced diabetic rats. Administration of the ethanolic extract of kernel at a concentration of 100 mg/kg of body weight significantly decreased the levels of blood glucose, blood urea, and cholesterol, increased glucose tolerance and levels of total proteins and liver glycogen, and decreased the activities of glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in experimental diabetic rats. Whole seed showed a moderate hypoglycemic effect, and seed coat did not show any hypoglycemic effect. The hypoglycemic efficacy was compared with that of glibenclamide, a standard hypoglycemic drug.
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India.
K
K
Ravi
K
K
Sivagnanam
S
S
Subramanian
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000032:analysis; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008099:Liver / Q000737:chemistry; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D028321:Plant Preparations / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D027842:Syzygium; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D028321:Plant Preparations; D014508:Urea; D006003:Glycogen; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase