A cholesterol biosynthesis inhibitor from Rhizopus oryzae.
A bile acid derivative, methyl cholate (1), was isolated from EtOAc extract of the fungus Rhizopus oryzae as a cholesterol biosynthesis inhibitor. It showed moderate inhibitory activity on cholesterol biosynthesis in human Chang liver cells. Compound 1 exhibited inhibitory effect on the later step of cholesterol biosynthesis, indicating that its action mode is different from that of statins that act on the HMG-CoA reductase.
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
Hyun Jung
HJ
Kim
Soon-Ho
SH
Yim
Ik-Soo
IS
Lee
D000924:Anticholesteremic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D020355:Cholates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002784:Cholesterol / Q000096:biosynthesis*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012233:Rhizopus / Q000737:chemistry*
D000924:Anticholesteremic Agents; D020355:Cholates; D010936:Plant Extracts; D002784:Cholesterol; C037034:methyl cholate