HIV infection and antiphospholipid antibody: literature review and link to the antiphospholipid syndrome.
There is a high incidence of antiphospholipid antibodies, detected by assays for anticardiolipin or lupus-like anticoagulant, in HIV disease. However, a link to the antiphospholipid syndrome, with clinical thrombosis, is tenuous. We report a case of a 25-year-old man with undetermined risk factors for HIV presenting with possible antiphospholipid syndrome manifesting as necrotic skin lesions as the initial clinical presentation for HIV. We also review the literature exploring the association between HIV and antiphospholipid syndrome.
Long Island Jewish Medical Center, Division of Infectious Diseases, New Hyde Park, New York, USA. ali_hasoun@yahoo.com
Ali
A
Hassoun
Zaid
Z
Al-Kadhimi
Joseph
J
Cervia
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000096:biosynthesis; D017152:Antibodies, Antiphospholipid / Q000096:biosynthesis*; D016736:Antiphospholipid Syndrome / Q000821:virology*; D015658:HIV Infections / Q000150:complications* / Q000276:immunology*; D006801:Humans; D008297:Male; D009336:Necrosis; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology; D013927:Thrombosis / Q000276:immunology / Q000473:pathology / Q000821:virology
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid