Studies on the synthesis and characterization of four trans-planaramineplatinum(II) complexes of the form trans-PtL(NH3)CL2 where L = 2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine.
Four trans-planaramineplatinum(II) complexes code named YH9, YH10, YH11 and YH12, each of the form trans-PtL(NH(3))Cl(2) where L = 2-hydroxypyridine and 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine for YH9, YH10, YH11 and YH12, respectively. All of the compounds have significant anticancer activity against human cancer cell lines. YH12 is found to be significantly more active than cisplatin against cisplatin-resistant ovary cell line A2780(cisR).
School of Biomedical Sciences, Cumberland Campus, C42, The University of Sydney, East Street, PO Box 170, Lidcombe, NSW 1825, Australia. f.huq@fhs.usyd.edu.au
Fazlul
F
Huq
Hassan
H
Daghriri
Jun Qing
JQ
Yu
Philip
P
Beale
Keith
K
Fisher
D045744:Cell Line, Tumor; D006801:Humans; D007093:Imidazoles / Q000032:analysis / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000032:analysis / Q000138:chemical synthesis*; D011725:Pyridines / Q000032:analysis / Q000138:chemical synthesis*; D011728:Pyridones / Q000032:analysis / Q000138:chemical synthesis*; D013059:Spectrum Analysis, Raman; D013941:Thymine / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis*
D007093:Imidazoles; D009944:Organoplatinum Compounds; C465244:Pt(MeNH(2))(2)(ChmT-N3); D011725:Pyridines; D011728:Pyridones; C023500:3-hydroxypyridine; C017679:2-hydroxypyridine; C029899:imidazole; C001439:imidazo(1,2-a)pyridine; D013941:Thymine