The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease.
luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod (Ixodes scapularis) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick transmitted to uninfected mice, and elicited histopathology in mice indistinguishable from that induced by wild-type B. burgdorferi.
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, 75390, USA.
Jon S
JS
Blevins
Andrew T
AT
Revel
Melissa J
MJ
Caimano
Xiaofeng F
XF
Yang
James A
JA
Richardson
Kayla E
KE
Hagman
Michael V
MV
Norgard
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D001733:Bites and Stings; D025065:Borrelia burgdorferi / Q000254:growth & development* / Q000472:pathogenicity* / Q000502:physiology; D013437:Carbon-Sulfur Lyases; D005260:Female; D018884:Ixodes / Q000382:microbiology*; D008193:Lyme Disease / Q000382:microbiology / Q000473:pathology / Q000635:transmission*; D051379:Mice; D008809:Mice, Inbred C3H; D009154:Mutation
D001426:Bacterial Proteins; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria