Inhibition of nitric oxide synthase exacerbates group B streptococcus sepsis and arthritis in mice.
The role of nitric oxide in group B Streptococcus (GBS) infection was evaluated by inhibiting its production with aminoguanidine (AG). AG-treated mice displayed higher mortality rates and more frequent and severe arthritis than controls. Worsening of arthritis correlated with a higher number of GBS cells in the joints and local interleukin-1 beta production.
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
Manuela
M
Puliti
Christina
C
von Hunolstein
Francesco
F
Bistoni
Graziella
G
Orefici
Luciana
L
Tissi
D000818:Animals; D021461:Animals, Outbred Strains; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality / Q000503:physiopathology*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000502:physiology* / Q000652:urine; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II; D018805:Sepsis / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology*; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality / Q000503:physiopathology*; D013292:Streptococcus agalactiae / Q000472:pathogenicity*
D004791:Enzyme Inhibitors; D006146:Guanidines; D009569:Nitric Oxide; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; C004479:pimagedine