Deoxystreptamine dimers bind to RNA hairpin loops.
RNA is known to have multiple roles in critical cellular functions. Thus, there is great potential for RNA-binding small molecules as both therapeutic agents and cellular probes. Unfortunately, the multiple secondary structures that RNA can adopt have caused difficulty in the development of a general paradigm for RNA-small molecule binding. In particular, the standard RNA-binding compounds such as aminoglycosides do not generally bind RNA hairpin loops, a widespread and vitally important secondary structural motif. In this manuscript we report that dimers of deoxystreptamine bind to RNA hairpin loops with affinities rivaling that of RNA-aminoglycoside interactions.
Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA.
Xianjun
X
Liu
Jason R
JR
Thomas
Paul J
PJ
Hergenrother
D001483:Base Sequence; D019281:Dimerization; D006595:Hexosamines / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry / Q000378:metabolism*
D006595:Hexosamines; D012313:RNA; C007265:2-deoxystreptamine