Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations.
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P=.0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.
Fang
Guowei
G
Wadsworth Center, NY State Department of Health, Albany, New York 12208, USA.
Kuiken
Carla
C
Weiser
Barbara
B
Rowland-Jones
Sarah
S
Plummer
Francis
F
Chen
Chih-Hsiung
CH
Kaul
Rupert
R
Anzala
Aggrey Omu
AO
Bwayo
Job
J
Kimani
Joshua
J
Philpott
Sean M
SM
Kitchen
Christina
C
Sinsheimer
Janet S
JS
Gaschen
Brian
B
Lang
Dorothy
D
Shi
Binshan
B
Kemal
Kimdar Sherefa
KS
Rostron
Tim
T
Brunner
Cheryl
C
Beddows
Simon
S
Sattenau
Quentin
Q
Paxinos
Ellen
E
Oyugi
Julius
J
Burger
Harold
H
D000328:Adult; D000483:Alleles; D018932:Chemokine CCL2 / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000472:pathogenicity; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008969:Molecular Sequence Data; D009784:Occupational Diseases / Q000453:epidemiology*; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000097:blood / Q000235:genetics*; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000235:genetics; D011477:Sex Work
C515334:CCR2 protein, human; D018932:Chemokine CCL2; D006680:HLA Antigens; D012367:RNA, Viral; D054390:Receptors, CCR2; D019707:Receptors, Chemokine