[Radioprotective capacity of indralin in reducing radiation injury to salivary glands].
Radioprotective capacity of radioprotector indraline (alpha-1(B)-adrenoagonist) was studied by its effect on early displays of a local radiation injury to salivary glands in white rats after X-ray irradiation of an animal head with a dose of 18.7 Gy. Indraline was found to be capable to reduce a radiation injury to parotid glands registered by reduction of gland mass on 6th day after irradiation. In experiments on rats, radioprotective efficiency of indraline (100 mg/kg) in term of DRF is close to 1.5.
Vasin
M V
MV
Ushakov
I B
IB
Korovkina
E P
EP
Kovtun
V Iu
VIu
D000818:Animals; D005260:Female; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D010636:Phenols / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D012469:Salivary Glands / Q000528:radiation effects*
D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin