Fungal biofilm formation on cochlear implant hardware after antibiotic-induced fungal overgrowth within the middle ear.
Cochlear implantation in patients with chronic suppurative otitis media is managed with perioperative antibiotics; however, fungal overgrowth can occur. We present a child who received oral cefdinir and topical ofloxacin (Floxin). After 6 weeks, a fungal (Candida) biofilm was demonstrated on the implant surface. In this clinical setting, an antimicrobial strategy using an oral antifungal to prevent fungal overgrowth is a possibility.
Department of Otolaryngology and Communication Sciences, University of Wisconsin, Milwaukee, Milwaukee, WI 53226-3596, USA.
Ricardo
R
Cristobal
Charles E
CE
Edmiston
Christina L
CL
Runge-Samuelson
Heather A
HA
Owen
Jill B
JB
Firszt
P Ashley
PA
Wackym
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001506:Beckwith-Wiedemann Syndrome; D018441:Biofilms; D002175:Candida / Q000254:growth & development*; D000077525:Cefdinir; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use; D003054:Cochlear Implants / Q000009:adverse effects* / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use; D010033:Otitis Media / Q000150:complications / Q000188:drug therapy*
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D002511:Cephalosporins; D015242:Ofloxacin; D000077525:Cefdinir