Endothelial cell function in patients with Down's syndrome.
Patients with Down's syndrome show an increased pulmonary vascular reactivity that could be due to an impaired vascular endothelial function, which is possibly related to increased oxidative stress. In 8 patients with Down's syndrome and 9 euploid patients of similar age, endothelium-dependent and -independent vasodilation was studied, measuring brachial flow velocity with an intravascular Doppler flow wire. Patients with Down's syndrome showed a significant impairment of endothelial function versus controls. In presence of the antioxidant vitamin C, endothelium-dependent vasodilation in the patients with Down's syndrome was only slightly, but not significantly, improved.
Cappelli-Bigazzi
Maurizio
M
Division of Pediatric Cardiology, 2nd University of Medicine, Monaldi Hospital, Naples, Italy. mcappelli@tin.it
Santoro
Giuseppe
G
Battaglia
Carmine
C
Palladino
Maria Teresa
MT
Carrozza
Marianna
M
Russo
Maria Giovanna
MG
Pacileo
Giuseppe
G
Calabrò
Raffaele
R
D000109:Acetylcholine / Q000008:administration & dosage; D000704:Analysis of Variance; D001205:Ascorbic Acid / Q000008:administration & dosage; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D042783:Endothelial Cells; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage; D018384:Oxidative Stress / Q000502:physiology*; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D018617:Ultrasonography, Doppler, Pulsed; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D005996:Nitroglycerin; D000109:Acetylcholine; D001205:Ascorbic Acid