Searching for transcription factor binding site clusters: how true are true positives?
The computational detection of functional transcription factor binding sites in genomic sequence is one of the challenges of the post-genomic era. Several groups have approached this problem from different directions and have demonstrated considerable success. The purpose of this communication, however, is to point out an imperfection in the way computational results are commonly reported that may lead to a distorted picture of the performance of existing algorithms.
Krivan
William
W
ZymoGenetics, Inc., 1201 Eastlake Avenue East, Seattle, Washington 98102, USA. krivan@zgi.com
D000465:Algorithms; D001665:Binding Sites; D016000:Cluster Analysis; D005188:False Negative Reactions; D005189:False Positive Reactions; D011485:Protein Binding; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA / Q000379:methods*; D014157:Transcription Factors / Q000235:genetics*
D014157:Transcription Factors