Soybean isoflavones eliminate nifedipine-induced flushing of tail skin in ovariectomized mice.
Hot flushes are one of the most frequent symptoms in menopausal women. We investigated effect of soybean isoflavones (Soyaflavone HG) on nifedipine-induced flushing in ovariectomized mice. Ovariectomy markedly aggravated nifedipine-induced increase in tail skin temperature. Soyaflavone HG (10 mg/kg, p.o., once a day for 5 days) inhibited nifedipine-induced flushing in ovariectomized mice. The inhibitory effect of Soyaflavone HG was significantly reversed by an estrogen-receptor antagonist, ICI 182,780, suggesting that Soyaflavone HG prevents nifedipine-induced flushing partially through estrogen receptors. We presented the experimental evidence suggesting that soybean isoflavones including Soyaflavone HG have the benefits for menopausal hot flushes.
Kai
Mamiko
M
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Yamauchi
Atsushi
A
Tominaga
Koji
K
Koga
Ayako
A
Kai
Hisashi
H
Kataoka
Yasufumi
Y
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D000077267:Fulvestrant; D019584:Hot Flashes / Q000139:chemically induced / Q000517:prevention & control*; D007529:Isoflavones / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008813:Mice, Inbred ICR; D009543:Nifedipine; D010052:Ovariectomy; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D012881:Skin Temperature / Q000187:drug effects; D013025:Glycine max; D013623:Tail / Q000503:physiopathology; D014665:Vasodilator Agents
D004965:Estrogen Antagonists; D007529:Isoflavones; D010936:Plant Extracts; D014665:Vasodilator Agents; D000077267:Fulvestrant; D004958:Estradiol; D009543:Nifedipine