[Effects of home pulmonary rehabilitation in patients with chronic respiratory failure and nutritional depletion].
BACKGROUND
The IRAD2 trial is evaluating a 3-month home intervention which includes education, oral supplements, exercise and androgenic steroids in undernourished patients with chronic respiratory failure. The main objective is to increase the six-minute walking distance by more than 50 m with an improvement in health-related quality-of-life. Secondary end-points include a reduction in exacerbation rates by 25%, a reduction in health-related costs and an increase in survival during the year following intervention.


METHODS
This interventional, multi-centre, prospective, two-armed parallel, controlled trial is being conducted in 200 patients. In both groups, "Control" and "Rehabilitation", 7 home visits are scheduled during the 3-month intervention for education purpose. In the "Rehabilitation" group, patients will receive 160 mg/d of oral testosterone undecanoate in men, 80 mg/d in women, oral dietary supplements (563 kcal/d) and exercises on an ergometric bicycle 3 to 5 times a week.


RESULTS
In the event of significant responses to intervention, this trial would validate a comprehensive and global home-care for undernourished patients with chronic respiratory failure combining therapeutic education, oral supplements, androgenic substitution and physical activity.
Département de Médecine Aiguë Spécialisée, Hôpital Michallon, CHU Grenoble, Université Joseph Fourier, France. CPison@chu-grenoble.fr
C
C
Pison
N
N
Cano
C
C
Chérion
H
H
Roth
C
C
Pichard
D000328:Adult; D005260:Female; D006699:Home Care Services; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000534:rehabilitation*; D011446:Prospective Studies; D012131:Respiratory Insufficiency / Q000150:complications / Q000534:rehabilitation*