Antioxidant properties of flavone-6(4')-carboxaldehyde oxime ether derivatives.
The in vitro antioxidant properties of some flavone-6(4)-carboxaldehyde oxime ether derivatives (Ia-f, IIa-f) were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels by measuring the formation of 2-thiobarbituric acid reactive substances. The free radical scavenging properties of the compounds were also examined in vitro by determining their capacity to scavenge superoxide anions and interact with the stable free radical 2, 2-diphenyl-1-picrylhydrazyl (DPPH). The most active compounds, IIb (Flavone-4'-carboxaldehyde-O-ethyl oxime) and Id (Flavone-6-carboxaldehyde-O-[2-(1-pyrolidino) ethyl] oxime), caused 98 and 79% inhibition of superoxide anion production and DPPH stable free radical at 10(-3) M, respectively.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandoğan-Ankara, Turkey. kilcigil@pharmacy.ankara.edu.tr
Gülgün
G
Ayhan-Kilcigil
Tülay
T
Coban
Meral
M
Tunçbilek
Benay
B
Can-Eke
Oya
O
Bozdağ-Dündar
Rahmiye
R
Ertan
Mümtaz
M
Iscan
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D010851:Picrates / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism; D013858:Thiobarbiturates / Q000378:metabolism
D000975:Antioxidants; D001713:Biphenyl Compounds; D047309:Flavones; D016166:Free Radical Scavengers; D005609:Free Radicals; D010851:Picrates; D013858:Thiobarbiturates; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl; C029684:thiobarbituric acid