Amino acid N-carboxyanhydrides: activated peptide monomers behaving as phosphate-activating agents in aqueous solution.
The hydrolysis of valine N-carboxyanhydride (NCA) in aqueous phosphate buffers was shown to proceed through nucleophilic catalysis via an aminoacyl phosphate intermediate that displays phosphorylating capabilities through a potentially prebiotic process that simulates modern biochemical metabolic pathways.
Biron
Jean-Philippe
JP
Organisation Moléculaire Evolution et Matériaux Fluorés UMR 5073 - CC 017, Département de Chimie, Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France.
Pascal
Robert
R
D000596:Amino Acids / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D010755:Organophosphates / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry
D000596:Amino Acids; D000812:Anhydrides; D010755:Organophosphates; D012996:Solutions; D014867:Water