Application of the poly-N-acetyl glucosamine-derived rapid deployment hemostat trauma dressing in severe/lethal Swine hemorrhage trauma models.
BACKGROUND
The Rapid Deployment Hemostat (RDH) Bandage was developed for the rapid control of bleeding caused by trauma.


METHODS
An extremity wound involving skin, muscle, bone, and femoral arterial injury and a 1-cm vertical incision in the abdominal aorta in swine were studied to compare the RDH Bandage, a fibrin sealant dressing and gauze to restore hemostasis. The total blood loss was determined and the survival of animals was measured.


RESULTS
In the extremity injury model, the RDH Bandage reduced blood loss by 63% compared with the gauze control. In the aorta arterial incision model, the RDH Bandage required a significantly lower compression time to control bleeding compared with gauze and TachoComb. The RDH Bandage was able to stop bleeding from this injury in 100% of the tests.


CONCLUSIONS
The RDH Bandage was superior to a commercially available fibrin bandage in controlling hemorrhage, decreasing blood loss, and increasing survival.
Department of Surgery, New England Medical Center, Boston, Massachusetts 02111, USA. rconnolly@tufts-nemc.org
Raymond J
RJ
Connolly
D000117:Acetylglucosamine / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001012:Aorta, Abdominal / Q000293:injuries; D007611:Aprotinin / Q000627:therapeutic use; D001458:Bandages / Q000592:standards*; D001772:Blood Cell Count; D001810:Blood Volume; D002626:Chemistry, Pharmaceutical; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005263:Femoral Artery / Q000293:injuries; D005340:Fibrinogen / Q000627:therapeutic use; D006470:Hemorrhage / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D006489:Hemostatic Techniques / Q000592:standards*; D006490:Hemostatics / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008887:Military Medicine / Q000379:methods; D010976:Platelet Count; D015996:Survival Rate; D013552:Swine; D013917:Thrombin / Q000627:therapeutic use; D013997:Time Factors; D014950:Wounds, Penetrating / Q000150:complications
D004338:Drug Combinations; D006490:Hemostatics; C113831:poly-N-acetyl glucosamine; C093991:tachocomb; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin; D000117:Acetylglucosamine