Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.
The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.
Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Research, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK. susan.pyne@strath.ac.uk
Susan
S
Pyne
Kok-Choi
KC
Kong
Peter I
PI
Darroch
D000818:Animals; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D010711:Phosphatidate Phosphatase / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism*
D008246:Lysophospholipids; D008565:Membrane Proteins; D043562:Receptors, G-Protein-Coupled; C060506:sphingosine 1-phosphate; C498527:SGPP1 protein, human; C112948:lipid phosphate phosphatase; C401298:sphingosine-1-phosphate phosphatase; D010744:Phosphoric Monoester Hydrolases; D010711:Phosphatidate Phosphatase; D013110:Sphingosine; C032881:lysophosphatidic acid