[Studies on antitussive, antiasthmatic and expectorant action of chenodeoxycholine acid].
OBJECTIVE
In this paper, antitussive, antiasthmatic and expectorant action of chenodeoxycholine acid (CDCA) were studied.


METHODS
The method of strong aqua ammoniae induced cough and sulfur dioxide induced cough, the method of tracheal volume and tracheal spiral line, and phenolsulfonphthalein excretion test.


RESULTS
CDCA was able to prolong cough latent period and decrease cough rate significantly in mice resulted from strong aqua ammoniae and sulfur doxide, and inhibit contraction of whole-body or extracorpored tracheal smooth muscle in guinea pig resulted from histamine phosphate. Besides, CDCA can increase phenolsulfonphthalein excretion quantity of trachea in mice, singnificantly.


CONCLUSIONS
CDCA has antitussive, antiasthmatic, expectorant actions.
Guan
Hong
H
The College of Animal Science and Medicine, Inner Mongolia Agricultural University, Huhehot, 010018.
Li
Peifeng
P
Zhao
Hongxia
H
D000641:Ammonia; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D000996:Antitussive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002635:Chenodeoxycholic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D005100:Expectorants / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008419:Materia Medica / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013458:Sulfur Dioxide; D014132:Trachea / Q000187:drug effects
D018927:Anti-Asthmatic Agents; D000996:Antitussive Agents; D005100:Expectorants; D008419:Materia Medica; D002635:Chenodeoxycholic Acid; D013458:Sulfur Dioxide; D000641:Ammonia