[Factors influencing axon regeneration after CNS damage].
In contrast to peripheral nerves, damaged axons in the mature mammalian brain and spinal cord rarely regenerate, and always lead to permanent loss of function. There are many reasons that inhibit the axon regeneration in the central nerve system, including the formation of glial scar, the deficiency of neurotrophic factors and the expression of inhibitory molecules. Here several factors, their structures, distributions, contributions and possible mechanisms are briefly reviewed.
Zhao
Min
M
Department of Neurobiology, Institute of Basic Medical Science, Academy of Military Medical Science, Beijing 100850.
Liu
Shao-Jun
SJ
D000818:Animals; D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000293:injuries* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology*