Using NMR for ligand discovery and optimization.
Several recent technology-driven advances in the area of NMR have rekindled an interest in the application of the technology to problems in drug discovery and development. A unique aspect of NMR is that it has applicability in broadly different areas of the drug discovery and optimization processes. NMR techniques for screening aimed at the discovery of novel ligands or low molecular weight structures for fragment-based build up procedures are being applied commonly in the industry. Application of NMR in structure-guided drug design and metabonomics are also becoming routine. We present an overview of some of the most recent NMR developments in these areas.
Triad Therapeutics, 9381 Judicial Dr., San Diego, California 92121, USA. hugo@altoris.com
Hugo O
HO
Villar
Jiangli
J
Yan
Mark R
MR
Hansen
D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008970:Molecular Weight
D008024:Ligands