Soybean isoflavones eliminate nifedipine-induced flushing of tail skin in ovariectomized mice.
Hot flushes are one of the most frequent symptoms in menopausal women. We investigated effect of soybean isoflavones (Soyaflavone HG) on nifedipine-induced flushing in ovariectomized mice. Ovariectomy markedly aggravated nifedipine-induced increase in tail skin temperature. Soyaflavone HG (10 mg/kg, p.o., once a day for 5 days) inhibited nifedipine-induced flushing in ovariectomized mice. The inhibitory effect of Soyaflavone HG was significantly reversed by an estrogen-receptor antagonist, ICI 182,780, suggesting that Soyaflavone HG prevents nifedipine-induced flushing partially through estrogen receptors. We presented the experimental evidence suggesting that soybean isoflavones including Soyaflavone HG have the benefits for menopausal hot flushes.
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Mamiko
M
Kai
Atsushi
A
Yamauchi
Koji
K
Tominaga
Ayako
A
Koga
Hisashi
H
Kai
Yasufumi
Y
Kataoka
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D000077267:Fulvestrant; D019584:Hot Flashes / Q000139:chemically induced / Q000517:prevention & control*; D007529:Isoflavones / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008813:Mice, Inbred ICR; D009543:Nifedipine; D010052:Ovariectomy; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D012881:Skin Temperature / Q000187:drug effects; D013025:Glycine max; D013623:Tail / Q000503:physiopathology; D014665:Vasodilator Agents
D004965:Estrogen Antagonists; D007529:Isoflavones; D010936:Plant Extracts; D014665:Vasodilator Agents; D000077267:Fulvestrant; D004958:Estradiol; D009543:Nifedipine