Chromosome damage and progression into and through mitosis in vertebrates.
How cells behave as they divide in the presence of chromosome (DNA) damage is only just beginning to be explored. It appears to depend on the cell type and organism, the stage of development, how extensive the damage is and when it occurs. The existing data support the conclusion that vertebrate somatic cells lack a conventional DNA damage checkpoint during mitosis, and that when damaged DNA does prolong mitosis it is mediated by the spindle assembly checkpoint. As a rule, in the presence of DNA damage cells ultimately undergo an aberrant mitosis and enter the ensuing G1. They then either die, via apoptosis or mitotic catastrophe, or survive with an altered genome. To avoid these outcomes, cells with DNA damage are normally prevented from entering mitosis by a number of G2 checkpoint control pathways.
Department of Biochemistry/NCBES, National University of Ireland-Galway, University Road, Galway, Ireland. ciaran.morrison@nuigalway.ie
Ciaran
C
Morrison
Conly L
CL
Rieder
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D002455:Cell Division; D002875:Chromosomes / Q000648:ultrastructure*; D004249:DNA Damage; D016193:G1 Phase; D016195:G2 Phase; D006801:Humans; D007834:Lasers; D008938:Mitosis; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D048051:p38 Mitogen-Activated Protein Kinases