[Clinical study on the severe hepatitis with nosocomial fungal infections and risk factors].
OBJECTIVE
To study the nosocomial fungal infections in the patient with severe hepatitis and analyze of risk factor.


METHODS
All 115 severe hepatitis with fungal infections inpatients was studied prospectively.


RESULTS
We identified 115 cases with fungal infections, the mean age of patients was 37.2+/-21.5 years, male: 49 cases, female 66 cases. Infection of abdominal cavity accounted for 40.9%, infectious rate in respiratory tract and digestive tract were 26.9%, 21.8%, respectively. Candida albicans accounted for 67.6%. Use of broad-spectrum antibiotic and corticosteroids, neutropenia, severity of liver disease, improper medical manipulations as significant risk factors for fungal infection. Death rate of study group and control group was 59.1%, 34.8%, respectively (x2=36.0). In multivariate analysis, neutropenia, disseminated infection and severity of liver diseases were independent prognostic factors.


CONCLUSIONS
Identification of risk factors and predictors of a poor outcome in patients with severe hepatitis with fungal infections, it suggested that implications in prophylaxis of fungal infection, early diagnosis and appropriate therapy would be important for these patients.
Ji'ning Infectious Diseases Hospital, Ji'ning 272031, China.
Xue-Hai
XH
Zhang
Guang-Hai
GH
Zhang
Chang-Jun
CJ
Man
Fang-Ming
FM
He
D000328:Adult; D002177:Candidiasis / Q000175:diagnosis / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D003428:Cross Infection / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index