[Effects of home pulmonary rehabilitation in patients with chronic respiratory failure and nutritional depletion].
BACKGROUND
The IRAD2 trial is evaluating a 3-month home intervention which includes education, oral supplements, exercise and androgenic steroids in undernourished patients with chronic respiratory failure. The main objective is to increase the six-minute walking distance by more than 50 m with an improvement in health-related quality-of-life. Secondary end-points include a reduction in exacerbation rates by 25%, a reduction in health-related costs and an increase in survival during the year following intervention.


METHODS
This interventional, multi-centre, prospective, two-armed parallel, controlled trial is being conducted in 200 patients. In both groups, "Control" and "Rehabilitation", 7 home visits are scheduled during the 3-month intervention for education purpose. In the "Rehabilitation" group, patients will receive 160 mg/d of oral testosterone undecanoate in men, 80 mg/d in women, oral dietary supplements (563 kcal/d) and exercises on an ergometric bicycle 3 to 5 times a week.


RESULTS
In the event of significant responses to intervention, this trial would validate a comprehensive and global home-care for undernourished patients with chronic respiratory failure combining therapeutic education, oral supplements, androgenic substitution and physical activity.
Pison
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Département de Médecine Aiguë Spécialisée, Hôpital Michallon, CHU Grenoble, Université Joseph Fourier, France. CPison@chu-grenoble.fr
Cano
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N
Chérion
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Roth
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H
Pichard
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C
D000328:Adult; D005260:Female; D006699:Home Care Services; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000534:rehabilitation*; D011446:Prospective Studies; D012131:Respiratory Insufficiency / Q000150:complications / Q000534:rehabilitation*