The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones.
Based on epothilones as powerful natural product leads several promising new anticancer agents have emerged through concerted efforts in chemistry and biology.
Altmann
Karl-Heinz
KH
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich.
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001685:Biological Factors / Q000138:chemical synthesis*; D035843:Biomedical Research / Q000639:trends*; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends*; D034261:Epothilones / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans
D000970:Antineoplastic Agents; D001685:Biological Factors; D034261:Epothilones