Whatever happened to cassette-dosing pharmacokinetics?
Cassette dosing is a procedure that is used for rapidly assessing the pharmacokinetics of a series of discovery drug candidates by dosing a mixture of compounds rather than a single compound. Cassette dosing has advantages and disadvantages associated with its use, which leads to controversy about how and if it should be used. To assess the current practices of the pharmaceutical industry regarding cassette dosing, a survey of several pharmaceutical companies was conducted. Analysis of the survey revealed that opinion on this subject is divided within the pharmaceutical industry. In addition, it was determined that approximately only a half of those companies that perform in vivo pharmacokinetic screening use cassette dosing for this purpose.
Manitpisitkul
Prasarn
P
Johnson & Johnson, Pharmaceutical Research & Development LLC, 920 US Route 202, Raritan, NJ, USA.
White
Ronald E
RE
D000818:Animals; D016503:Drug Delivery Systems; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004345:Drug Industry / Q000706:statistics & numerical data*; D010599:Pharmacokinetics