Role of flagellum and motility in pathogenesis of Vibrio vulnificus.
To assess the role of the flagellum which was detected by immunoscreening of surface proteins of Vibrio vulnificus, an flgE-deleted mutant was constructed and tested for its pathogenicity. The ability of this nonmotile mutant to adhere to INT-407 cells and its role in biofilm were decreased, as was its lethality to mice.
Lee
Jong-Ho
JH
Department of Parasitology and Institute of Tropical Medicine, BK21 Project for Medical Science, Yonsei University, Seoul 120-752, Korea.
Rho
Jong Bok
JB
Park
Kyung-Je
KJ
Kim
Chang Beom
CB
Han
Yang-Soo
YS
Choi
Sang Ho
SH
Lee
Kyu-Ho
KH
Park
Soon-Jung
SJ
D000818:Animals; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development; D002460:Cell Line; D005260:Female; D005407:Flagella / Q000502:physiology*; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D009068:Movement; D009154:Mutation; D014735:Vibrio Infections / Q000382:microbiology / Q000401:mortality; D041261:Vibrio vulnificus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology
D001426:Bacterial Proteins; C097681:FlgE protein, Bacteria