Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin.
Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) influencing whole blood serotonin in 567 members of a single large pedigree, using a novel association-based mapping approach. We identified an association between the beta3 integrin (ITGB3) Leu33Pro polymorphism on 17q21 and whole blood serotonin levels (P-value = 9.8 x 10(-5)). This variant explained the evidence for linkage in this region when included as a covariate in the linkage analysis (change in LOD from 1.87 to 0.16), indicating that ITGB3 may be an important serotonin QTL.
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Lauren A
LA
Weiss
Jeremy
J
Veenstra-Vanderweele
Dina L
DL
Newman
Soo-Jeong
SJ
Kim
Harvey
H
Dytch
Mary Sara
MS
McPeek
Suzanne
S
Cheng
Carole
C
Ober
Edwin H
EH
Cook
Mark
M
Abney
D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D040641:Quantitative Trait Loci; D012701:Serotonin / Q000097:blood*
C061248:ITGB3 protein, human; D039661:Integrin beta3; D012701:Serotonin