Chk1 activation and the nuclear/cytoplasmic ratio.
ATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of Developmental Cell, Conn et al. shed a novel light on the molecular mechanism of Chk1 activation and raise the possibility of a developmental checkpoint that regulates Chk1 in response to the nuclear/cytoplasmic ratio.
Ben May Institute for Cancer Research, Committee on Cancer Biology, University of Chicago, 924 East 57th Street, IL 60637 USA.
Jennifer
J
Pogoriler
Wei
W
Du
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D000071877:Checkpoint Kinase 1; D003593:Cytoplasm / Q000378:metabolism*; D004789:Enzyme Activation; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D020687:cdc25 Phosphatases / Q000378:metabolism
D018797:Cell Cycle Proteins; D011494:Protein Kinases; D000071877:Checkpoint Kinase 1; D017346:Protein Serine-Threonine Kinases; D020687:cdc25 Phosphatases