Autoimmune manifestations in common variable immunodeficiency.
Common variable immunodeficiency (CVID) is a disorder characterized by decreased serum immunoglobulin concentrations and increased incidence of recurrent infections. Interestingly 20-25% of patients with CVID develop clinical features suggestive of an autoimmune disease. Although this association is well established, the immunodeficiency background of CVID patients manifesting autoimmune disorders is often overlooked. This study describes three CVID patients displaying a variety of autoimmune manifestations. The pathophysiologic mechanisms of autoimmunity in CVID are also reviewed.
Giannouli
Stavroula
S
Department of Pathophysiology, Medical School, National University of Athens, M. Asias 75, Goudi, 11527, Greece.
Anagnostou
Dimitra
D
Soliotis
Fotini
F
Voulgarelis
Michalis
M
D000328:Adult; D015551:Autoimmunity / Q000276:immunology*; D017074:Common Variable Immunodeficiency / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D011239:Prednisolone