Intranuclear trafficking: organization and assembly of regulatory machinery for combinatorial biological control.
The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.
Zaidi
Sayyed K
SK
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA.
Young
Daniel W
DW
Choi
Je-Yong
JY
Pratap
Jitesh
J
Javed
Amjad
A
Montecino
Martin
M
Stein
Janet L
JL
Lian
Jane B
JB
van Wijnen
Andre J
AJ
Stein
Gary S
GS
D002467:Cell Nucleus / Q000235:genetics / Q000502:physiology; D002468:Cell Physiological Phenomena; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015870:Gene Expression; D006706:Homeostasis; D008954:Models, Biological; D011506:Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
D011506:Proteins; D004247:DNA