Acute vanishing bile duct syndrome after ibuprofen therapy in a child.
We report the case of a 10 year-old girl who had Stevens-Johnson syndrome and cholestasis after ibuprofen therapy. Liver histology was compatible with vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver tests normalized within 7 months. This report confirms that ibuprofen may induce acute vanishing bile duct syndrome.
Pediatric Unit, Vesoul Hospital, Vesoul, France.
M
M
Taghian
T A
TA
Tran
S
S
Bresson-Hadni
A
A
Menget
S
S
Felix
E
E
Jacquemin
D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001649:Bile Duct Diseases / Q000139:chemically induced* / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D002648:Child; D002779:Cholestasis / Q000139:chemically induced; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced; D013577:Syndrome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen