Further membranolide diterpenes from the antarctic sponge dendrilla membranosa.
Chemical investigation of the Antarctic sponge Dendrilla membranosa collected from the vicinity of Palmer Station on Anvers Island, Antarctica, yielded three new diterpenes, membranolides B-D (2-4), as well as three previously reported sponge metabolites. Membranolides C and D (3, 4), bearing carboxylic acid functional groups, display Gram-negative antibiotic and antifungal activities.
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue SCA400, Tampa, FL 33620, USA.
Sridevi
S
Ankisetty
Charles D
CD
Amsler
James B
JB
McClintock
Bill J
BJ
Baker
D000818:Animals; D000864:Antarctic Regions; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004224:Diterpenes; C489100:membranolide B; C489101:membranolide C; C489102:membranolide D