EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies.
Nasopharyngeal carcinoma is a human malignancy consistently associated with the Epstein-Barr virus. Exposure to non-viral carcinogens and genetic predisposition are other crucial etiologic factors. Tumor development appears to require the expression of a small subset of transforming viral RNAs and proteins with concomitant silencing of most other viral genes. Impairment of the interactions of viral proteins with cellular partners or disruption of viral latency might prove to be useful for novel therapeutic strategies.
Busson
Pierre
P
UMR 8126, CNRS and Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France. pbusson@igr.fr
Keryer
Cécile
C
Ooka
Tadamassa
T
Corbex
Marilys
M
D006566:Herpesviridae Infections / Q000150:complications* / Q000453:epidemiology; D004854:Herpesvirus 4, Human; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000821:virology*