Construction of maximum-entropy density maps, and their use in phase determination and extension.
Methods for constructing everywhere-positive electron-density maps with Fourier amplitudes matching those for arbitrarily large sets of observed data, utilizing dual-function methods for maximization of entropy, are described. Possible strategies for utilizing these maps for the determination and extension of phases in macromolecular structure determination are suggested, and problems are discussed.
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Materials Science and Engineering Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.