Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseases.
Coenzyme Q10 (Q10) is available as an over-the-counter dietary supplement in the United States. While its use could be considered a form of alternative therapy, the medical profession has embraced the use of Q10 in specific disease states, including a series of neurologic and muscular diseases. Clinical laboratory monitoring is available for measurement of total Q10 in plasma and tissue and for measurement of redox status, ie, the ratio of reduced and oxidized forms of Q10. Many published studies have been anecdotal, in part owing to the rarity of some diseases involved. Unfortunately, many studies do not report Q10 levels, and, thus, the relationship of clinical response to Q10 concentration in plasma frequently is not discernible. Consistent laboratory monitoring of patients treated with this compound would help ease interpretation of the results of the treatment, especially because so many formulations of Q10 exist in the marketplace, each with its own bioavailability characteristics. Q10 has an enviable safety profile and, thus, is ideal to study as an adjunct to more conventional therapy. Defining patient subpopulations and characteristics that predict benefit from exogenous Q10 and defining therapeutic ranges for those particular applications are major challenges in this field.
Steele
Paul E
PE
Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati 45229-3039, USA.
Tang
Peter H
PH
DeGrauw
Antonius J
AJ
Miles
Michael V
MV
D003067:Coenzymes; D004831:Epilepsies, Myoclonic / Q000097:blood; D005621:Friedreich Ataxia / Q000097:blood; D006801:Humans; D006816:Huntington Disease / Q000097:blood; D007625:Kearns-Sayre Syndrome / Q000097:blood; D017237:Mitochondrial Encephalomyopathies / Q000097:blood; D009135:Muscular Diseases / Q000097:blood*; D009422:Nervous System Diseases / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood* / Q000172:deficiency
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10