Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil.
We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma.
Cruz
Márcio R
MR
Instituto de Biologia, Universidade de Brasília, Brasília, DF, 70919-900, Brasil.
Cerqueira
Daniela M
DM
Cruz
Waldenor B
WB
Camara
Geni N L
GN
Brígido
Marcelo M
MM
Silva
Evandro O
EO
Carvalho
Luciano G S
LG
Martins
Cláudia R F
CR
D000595:Amino Acid Sequence; D001938:Brazil / Q000453:epidemiology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012720:Severity of Illness Index; D002577:Uterine Cervical Diseases / Q000453:epidemiology / Q000821:virology*