Multicenter evaluation of a new screening test that detects Clostridium difficile in fecal specimens.
Clostridium difficile causes approximately 25% of nosocomial antibiotic-associated diarrheas and most cases of pseudomembranous colitis. We evaluated C. DIFF CHEK, a new screening test that detects glutamate dehydrogenase of C. difficile. Our results showed that this test was comparable to PCR in sensitivity and specificity and outperformed bacterial culture.
TechLab, Inc., 2001 Kraft Dr., Blacksburg, VA 24061, USA. zhengl@techlab.com
L
L
Zheng
S F
SF
Keller
D M
DM
Lyerly
R J
RJ
Carman
C W
CW
Genheimer
C A
CA
Gleaves
S J
SJ
Kohlhepp
S
S
Young
S
S
Perez
K
K
Ye
D015415:Biomarkers / Q000032:analysis; D016360:Clostridioides difficile / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D003428:Cross Infection / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control; D003967:Diarrhea / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis* / Q000517:prevention & control; D005243:Feces / Q000382:microbiology*; D005969:Glutamate Dehydrogenase / Q000032:analysis*; D006801:Humans; D008403:Mass Screening / Q000379:methods; D016133:Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity
D015415:Biomarkers; D005969:Glutamate Dehydrogenase