Effectiveness of sirolimus-eluting stent implantation for treatment of in-stent restenosis after brachytherapy failure.
The impact of the use of sirolimus-eluting stents (SESs) in the treatment of in-stent restenosis in previously irradiated sites has not been adequately evaluated. Fifteen consecutive patients who underwent percutaneous coronary interventions using SESs in lesion sites previously intervened with intracoronary radiation therapy were identified. All stents were implanted successfully, and there were no major in-hospital complications. At 30-day follow-up, there was 1 case of subacute thrombosis that led to target lesion revascularization (TLR). At 6 months, 2 patients underwent TLR because of recurrent angina with angiographic restenosis, and 1 patient underwent target vessel revascularization distally to the SES site; no other major adverse cardiac events occurred at long-term follow-up (mean 17 +/- 8 months).
EMO Centro Cuore Columbus, Milan, Italy.
Ioannis
I
Iakovou
Giuseppe M
GM
Sangiorgi
Goran
G
Stankovic
Nicola
N
Corvaja
Iassen
I
Michev
Alaide
A
Chieffo
Renata
R
Rogacka
Giancarlo
G
Vitrella
Flavio
F
Airoldi
Antonio
A
Colombo
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation* / Q000379:methods; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000628:therapy; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents / Q000009:adverse effects*; D017211:Treatment Failure; D016896:Treatment Outcome
D020123:Sirolimus