Hypopituitarism presenting as a mixed hyperlipidaemia.
A case report is presented of a 37-year-old man who, largely by chance, was found to have a marked mixed hyperlipidaemia. As a teenager he had been treated for apparent idiopathic growth hormone deficiency, but had also never developed secondary sexual characteristics. Pituitary hormone measurement was now consistent with hypopituitarism and magnetic resonance imaging showed hypoplasia of his pituitary stalk as the likely cause. His hyperlipidaemia improved after appropriate hormone replacement. He thus appears to have had a mixed hyperlipidaemia secondary to hypopituitarism, which was secondary to a pituitary stalk abnormality, which in turn may have been associated to the trauma surrounding his normal breech delivery.
Department of Clinical Biochemistry, Hull Royal Infirmary, Hull HU3 2JZ, UK.
Eric S
ES
Kilpatrick
Jane E
JE
Patmore
Christopher
C
Rowland-Hill
Stephen L
SL
Atkin
D000328:Adult; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000175:diagnosis* / Q000209:etiology*; D007018:Hypopituitarism / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000473:pathology; D010907:Pituitary Hormones / Q000097:blood; D013739:Testosterone / Q000627:therapeutic use
D010907:Pituitary Hormones; D013739:Testosterone; D006854:Hydrocortisone