Challenging diagnosis--icterus associated with a single perforating duodenal ulcer after long-term nonsteroidal antiinflammatory drug administration in a dog.
A dog developed icterus, vomiting, and anorexia 2 wk after orthopedic surgery and treatment with meloxicam for approximately 1 y. Exploratory laparotomy revealed a single perforated duodenal ulcer. The most likely cause of the hyperbilirubinemia was intrahepatic cholestasis resulting from peritonitis associated with the perforation.
University of Saskatchewan, Veterinary Teaching Hospital, Western College of Veterinary Medicine, Department of Small Animal Clinical Sciences, 52 Campus Drive, Saskatoon, Saskatchewan. felix.duerr@usask.ca
Felix M
FM
Duerr
Anthony P
AP
Carr
Trevor N
TN
Bebchuk
Neil C
NC
Pople
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D007565:Jaundice / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008297:Male; D000077239:Meloxicam; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000662:veterinary; D010439:Peptic Ulcer Perforation / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D013843:Thiazines / Q000009:adverse effects* / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam