Effect of Noolit, a novel lithium preparation, on electrophysiological activity of rat cerebral cortex.
The effects of lithium carbonate and Noolit, a novel lithium enterosorbent, on electrophysiological activity of cerebral cortex in rats were compared. Both agents potentiated the theta-, alpha-, and beta-rhythms and modified the response to rhythmic flash stimulation from potentiation to inhibition of cerebral rhythms. Moreover, these drugs increased dispersion of all rhythms. By contrast to lithium carbonate, the effect of Noolit was milder and developed more slowly.
Institute of Pharmacology, Tomsk Research Center; Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
N I
NI
Suslov
A A
AA
Fedorov
O V
OV
Pershina
Yu I
YI
Borodin
L N
LN
Rachkovskaya
D000513:Alpha Rhythm / Q000187:drug effects; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001611:Beta Rhythm / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology*; D003700:Delta Rhythm / Q000187:drug effects; D004594:Electrophysiology; D008094:Lithium / Q000494:pharmacology*; D016651:Lithium Carbonate / Q000494:pharmacology; D008297:Male; D051381:Rats
D000928:Antidepressive Agents; C449664:noolith; D016651:Lithium Carbonate; D008094:Lithium