Comparative study on toxicokinetics of bisphenol A in F344 rats, monkeys (Macaca fascicularis), and chimpanzees (Pan troglodytes).
We compared the toxicokinetics of bisphenol A (BPA) among three animal species: rats, cynomolgus monkeys and chimpanzees. Rats and monkeys were administered BPA orally or subcutaneously at 10 or 100 mg/kg body weight, while chimpanzees were administered only 10 mg/kg of BPA. BPA in serum was measured by ELISA. In oral administration of BPA at 10 mg/kg, both C(max) and AUC were rats < chimpanzee < monkeys. In oral administration of BPA at 100 mg/kg, both C(max) and AUC were rats < monkeys. Subcutaneous BPA administrations also revealed similar results, although the values of toxicokinetic parameters in subcutaneous administration were higher than those in oral administration. These results suggest that orally or subcutaneously administered BPA in primates is more easily absorbed than that in rats. We conclude that there are considerable differences in distribution, metabolism, and excretion of BPA between rodents and primates.
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Takayuki
T
Negishi
Toshikazu
T
Tominaga
Yoshiyuki
Y
Ishii
Shigeru
S
Kyuwa
Ikuo
I
Hayasaka
Yoichiro
Y
Kuroda
Yasuhiro
Y
Yoshikawa
D000818:Animals; D001559:Benzhydryl Compounds; D005260:Female; D008252:Macaca fascicularis / Q000378:metabolism*; D002679:Pan troglodytes / Q000378:metabolism*; D010636:Phenols / Q000493:pharmacokinetics*; D051381:Rats / Q000378:metabolism*; D011916:Rats, Inbred F344; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds