Legionella micdadei pneumonia diagnosed by culture isolation and DNA-dNA hybridization from bronchial lavage fluid.
An 80-year-old man was admitted because of dyspnea on effort. We suspected an acute exacerbation of chronic heart failure and idiopathic interstitial pneumonia caused by right-sided pneumonia. A nodular shadow in right upper lobe spread and consolidated into the airspace, and it failed to improve despite administration of meropenem trihydrate, vancomycin hydrochloride and clindamycin. A definitive diagnosis of Legionella micdadei pneumonia was made on the basis of this organism being isolated in culture from bronchial lavage fluid and subsequent identification of Legionella micdadei using DNA-DNA hybridization. The airspace consolidation gradually improved following treatment with intravenous erythromycin and minocycline hydrochloride.
Department of Respiratory Disease, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima.
Yoshihiro
Y
Kitahara
Ryohei
R
Nishino
Tadahiro
T
Kohara
Haruko
H
Daga
Yasuyuki
Y
Taooka
Nobuyuki
N
Ohashi
Ken-Ichi
K
Arita
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001431:Bacteriological Techniques / Q000379:methods; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology*; D004269:DNA, Bacterial / Q000302:isolation & purification*; D004917:Erythromycin / Q000627:therapeutic use; D006801:Humans; D007875:Legionella / Q000302:isolation & purification*; D007876:Legionellosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008911:Minocycline / Q000627:therapeutic use; D009693:Nucleic Acid Hybridization / Q000379:methods; D011014:Pneumonia / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004917:Erythromycin; D008911:Minocycline