Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient.
We describe here a severe flare of hepatitis caused by lamivudine-resistant hepatitis B virus(HBV) in an HIV/HBV co-infected individual.Lamivudine-resistant HBV was detected 6 months before the development of severe hepatitis. Sequencing of the HBV genome isolated from the patients' serum did not identify compensatory mutations in the HBV polymerase that may have restored viral replication. However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis.
Gouskos
Theo
T
Department of Medicine (RMH), University of Melbourne, Melbourne, Australia.
Wightman
Fiona
F
Chang
Judy
J
Earnest-Silveira
Linda
L
Sasadeusz
Joseph
J
Lewin
Sharon R
SR
Torresi
Joseph
J
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001483:Base Sequence; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004279:DNA, Viral / Q000032:analysis; D024882:Drug Resistance, Viral; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000150:complications / Q000235:genetics / Q000276:immunology*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D009154:Mutation; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D014779:Virus Replication / Q000235:genetics / Q000276:immunology
D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine