Epidemiology of multiple system atrophy: a prevalence and pilot risk factor study in Aquitaine, France.
We investigated the prevalence of multiple system atrophy (MSA) in Gironde, France, through a network of 120 public and private specialists and assessed the relationship between some environmental factors and MSA in a case-control study involving 50 MSA patients, 50 Parkinson's disease (PD) patients and 50 healthy controls. The occupational exposure to pesticides was evaluated through a job-exposure matrix. On prevalence day (November 1, 1998), the crude prevalence of MSA in Gironde was 1.94/100,000 inhabitants. We found no significant relationship between occupational exposure to pesticides and MSA. PD patients were significantly less frequently ever-smokers than controls and the same tendency was observed for MSA patients. We also described the clinical features that heralded the disease among this nonselected population.
Chrysostome
V
V
Federation of Neurology, Epidemiology and Biostatistics, Centre Hospitalo-Universitaire de Bordeaux, Bordeaux, France.
Tison
F
F
Yekhlef
F
F
Sourgen
C
C
Baldi
I
I
Dartigues
J F
JF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004777:Environment; D016021:Epidemiologic Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure; D010575:Pesticides / Q000506:poisoning*; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D010575:Pesticides