Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma.
Oxidative stress is believed to initiate and aggravate many diseases including peptic ulcers and gastric carcinoma. We observed an increase in rat gastric mucosal lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in cold restraint stress-induced gastric ulceration while, in clinical peptic ulceration and gastric carcinoma patients, an increase in serum LPO and a tendency to decrease in SOD and CAT levels were observed. The result thus, indicated a positive correlation between free radical-induced oxidative stress both in gastric and duodenal ulcers and gastric carcinoma.
Tandon
R
R
Division of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi--221 005.
Khanna
H D
HD
Dorababu
M
M
Goel
R K
RK
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D003080:Cold Temperature; D004381:Duodenal Ulcer / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D010437:Peptic Ulcer / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D012149:Restraint, Physical; D013274:Stomach Neoplasms / Q000378:metabolism*; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase