Transcervical polidocanol as a nonsurgical method of female sterilization: a pilot study.
We have studied the effects of transcervically administered polidocanol on uterine and fallopian tube morphology in Wistar rats and Rhesus monkeys. Polidocanol is a synthetic, long-chain fatty acid that is widely used as a sclerosing agent in Europe. The goal of the study was to determine whether polidocanol would safely cause tubal occlusion in an animal model. Twenty female Wistar rats and three female Rhesus monkeys underwent transcervical injection of polidocanol or physiological saline. The animals were followed for 30 days and then a lower laparotomy was performed, with excision of the entire upper reproductive tract. Specimens were subsequently examined for macroscopic and microscopic changes. Only cyclic changes were observed in the control animals of both species. Fifteen macroscopic and 37 microscopic changes were observed in the uterine horns of the 10 rats treated with polidocanol. There was no observed effect in the monkey fallopian tube. These results suggest that species differences that exist between rodents and primates may influence the effects of transcervical polidocanol. Experiments using a primate model are needed as proof of concept prior to human studies of candidate agents for transcervical tubal sterilization.
Division of Reproductive Sciences, Oregon Regional Primate Research Center, Department of Obstetrics and Gynecology Oregon Health and Science University, Portland, OR, USA. jensenje@ohsu.edu
J T
JT
Jensen
M I
MI
Rodriguez
J
J
Liechtenstein-Zábrák
S
S
Zalanyi
D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects*; D005260:Female; D007267:Injections; D008253:Macaca mulatta; D023421:Models, Animal; D010865:Pilot Projects; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013245:Sterilization, Reproductive / Q000379:methods*
D000077423:Polidocanol; D011092:Polyethylene Glycols