[Herpes simplex 1 virus Mollaret meningitis].
Mollaret meningitis is a rare disease characterized by recurrent and self-limited episodes of aseptic meningitis. It is considered a disease with benign etiology and it has been related to viral infections: Epstein-Barr virus and herpes simplex virus (HSV), type 2 most frequently. Herpes simplex 1 virus has been rarely isolated in the cerebrospinal fluid in patients with Mollaret meningitis; to this end culture, expansion with PCR, and inmunoblot has been utilized. In this article a case of Mollaret meningitis related to type 1 HSV is described. The interest is the demonstration of the herpes simplex virus type 1 within the cytoplasm of the Mollaret cells with a immunohistochemical technique (ABC-peroxidase method) using monoclonal antibodies anti HSV-1 in order to support the diagnosis, being this the first case described in the literature.
Unidad de Enfermedades Infecciosas, Hospital Universitario Dr. Peset, Valencia.
J
J
Carmena Carmena
M
M
Macià Soler
A
A
Cremades Mira
M J
MJ
Alcaraz Soriano
D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D006561:Herpes Simplex / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000821:virology*; D008875:Middle Aged
D000998:Antiviral Agents; D000212:Acyclovir