Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know.
The field of vaccinology began in ignorance of how protection was instilled in vaccine recipients. Today, a greater knowledge of immunology allows us to better understand what is being stimulated by various vaccines that leads to their protective effects: that is, their correlates of protection. Here we describe what is known about the correlates of protection for existing vaccines against a range of different viral diseases and discuss the correlates of protection against disease during natural infection with HIV-1. We will also discuss why it is important to design phase 3 clinical trials of HIV vaccines to determine the correlates of protection for each individual vaccine.
Pantaleo
Giuseppe
G
Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland. giuseppe.pantaleo@chuv.hospvd.ch
Koup
Richard A
RA
D016915:AIDS Vaccines / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D015166:Monitoring, Immunologic / Q000379:methods; D014777:Virus Diseases / Q000276:immunology*
D016915:AIDS Vaccines