Antiinflammatory and antiulcer activities of phytic acid in rats.
Maximum antiinflammatory activity of phytic acid (PA) was seen at an oral dose of 150 mg/kg in the carrageenan induced rat paw edema model. Although PA showed ability to prevent denaturation of proteins, it showed less antiinflammatory activity than ibuprofen. Ability of PA to bring down thermal denaturation of proteins might be a contributing factor in the mechanism of action against inflammation. PA, at all the doses tested, showed significant protection from ulcers induced by ibuprofen, ethanol and cold stress, with a maximum activity at 150 mg/kg. There was a significant increase in gastric tissue malondialdehyde levels in ethanol treated rats but these levels decreased following PA pretreatment. Moreover, pretreatment with PA significantly inhibited various effects of ethanol on gastric mucosa, such as, reduction in the concentration of nonprotein sulfhydryl groups, necrosis, erosions, congestion and hemorrhage. These results suggested that gastro-protective effect of PA could be mediated by its antioxidant activity and cytoprotection of gastric mucosa.
Sudheer Kumar
M
M
Department of Pharmacology, College of Pharmaceutical Sciences, Manipal 576 119, India.
Sridhar Reddy
B
B
Kiran Babu
S
S
Bhilegaonkar
P M
PM
Shirwaikar
A
A
Unnikrishnan
M K
MK
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use* / Q000633:toxicity; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D003080:Cold Temperature; D000431:Ethanol / Q000633:toxicity; D015738:Famotidine / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects*; D006470:Hemorrhage; D007052:Ibuprofen / Q000633:toxicity; D008315:Malondialdehyde / Q000378:metabolism; D009336:Necrosis; D010833:Phytic Acid / Q000627:therapeutic use*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D013312:Stress, Physiological; D013438:Sulfhydryl Compounds / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D013438:Sulfhydryl Compounds; D000431:Ethanol; D008315:Malondialdehyde; D015738:Famotidine; D010833:Phytic Acid; D007052:Ibuprofen