Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major.
The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
Helton da Costa
HC
Santiago
Carolina Ferreira
CF
Oliveira
Luciana
L
Santiago
Fernanda Oliveira
FO
Ferraz
Daniele da Glória
D G
de Souza
Luiz Antônio Rodrigues
LA
de-Freitas
Luís Carlos Crocco
LC
Afonso
Mauro Martins
MM
Teixeira
Ricardo Tostes
RT
Gazzinelli
Leda Quercia
LQ
Vieira
D000818:Animals; D018946:Chemokine CCL5 / Q000378:metabolism*; D018320:Leishmania major; D016773:Leishmaniasis, Cutaneous / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
D018946:Chemokine CCL5