Effects of Central Kalimantan plant extracts on intraerythrocytic Babesia gibsoni in culture.
The inhibitory effects of 45 plant extracts selected from Central Kalimantan, Indonesia on Babesia gibsoni in vitro and their acute toxicity to mice were evaluated. Of these plant extracts studied, Arcangelisia flava, Curcuma zedoaria, Garcinia benthamiana, Lansium domesticum and Peronema canescens were found to have appreciable antibabesial activity with IC50 values from 5.3 to 49.3 microg/ml without acute toxicity in mice at the intraperitoneal dose of 0.7 g/kg of body weight.
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Subeki
Hideyuki
H
Matsuura
Masahiro
M
Yamasaki
Osamu
O
Yamato
Yoshimitsu
Y
Maede
Ken
K
Katakura
Mamoru
M
Suzuki
Trimurningsih
Chairul
Teruhiko
T
Yoshihara
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001403:Babesia / Q000187:drug effects*; D007214:Indonesia; D020128:Inhibitory Concentration 50; D007274:Injections, Intraperitoneal / Q000662:veterinary; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D018517:Plant Roots; D018547:Plant Stems; D027343:Rhizome
D000981:Antiprotozoal Agents; D010936:Plant Extracts