Blood antioxidant parameters in patients with diabetic retinopathy.
It has been postulated that enhanced generation of reactive oxygen species (ROS) may take part in a pathogenesis of diabetic microvascular complication - retinopathy. There are two types of diabetic retinopathy, non-proliferative (simplex) and proliferative. ROS are anihilated by an intracelluar enzymatic system composed mainly of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT). Beta-carotene, tocopherols and ascorbic acid are major components of serum antioxidants. All serum antioxidants are usually measured together as total antioxidant status (TAS). Erythrocyte activities of GPx, SOD, CAT and TAS were measured in diabetic patients without retinopathy, with non-proliferative and proliferative retinopathy. Obtained results were correlated with a period of diabetic history and a period of insulin treatment. SOD was significantly elevated in diabetics with non-proliferative retinopathy compared to patients without retinopathy. TAS was significantly lower in patients with proliferative retinopathy than in diabetics not developing retinopathy. Only CAT was significantly negatively correlated with the period of insulin treatment. This significant negative correlation was also observed in a subgroup of patients with proliferative retinopathy.
Department of Experimental and Clinical Biochemistry, Silesian Medical Academy, 40-752 Katowice, Poland. ksiem@mp.pl
Krzysztof
K
Siemianowicz
Jan
J
Gminski
Alicja
A
Telega
Aneta
A
Wójcik
Barbara
B
Posielezna
Rozalia
R
Grabowska-Bochenek
Tomasz
T
Francuz
D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000201:enzymology; D003930:Diabetic Retinopathy / Q000097:blood* / Q000145:classification* / Q000201:enzymology / Q000473:pathology; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D007004:Hypoglycemic Agents; D007328:Insulin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase