[The effects of PL-derived growth factor on osteogenesis and skeletal reconstruction].
Platelet-derived growth factor (PDGF) plays an important role in osteogenesis and skeletal reconstruction. PDGF participates in the process of osteogenesis and bone absorption simultaneously. It stimulates the marrow stromal mesenchymal cell to proliferate and differentiate, accelerates the calcium aggradation into extracellular matrix, and stimulates chondrocytes proliferation and differentiation. Furthermore, PDGF can act on osteoclasts directly or indirectly to promote bone absorption. The dual-effects of PDGF facilitate osteogenesis and skeletal reconstruction.
Department of Oral and Maxillofacial Surgery, Peking University, School of Stomatology, Beijing 100081, China.
Quan-Feng
QF
Luo
Xing
X
Wang
D016723:Bone Remodeling; D006801:Humans; D010006:Osteoblasts; D010010:Osteoclasts; D010012:Osteogenesis; D010982:Platelet-Derived Growth Factor / Q000502:physiology*
D010982:Platelet-Derived Growth Factor