[Cytochemical activity of mitochondrial enzymes in Parkinson's disease].
Using cytochemical computerized morphometric method, activity of the key enzymes of energetic metabolism (succinate dehydrogenase, alpha-glycerophosphate dehydrogenase, malate dehydrogenase, glutamate dehydrogenase and lactate dehydrogenase) was studied in blood lymphocytes of 75 patients with Parkinson's disease and 15 healthy controls. The signs of systemic mitochondrial insufficiency, which correlated with the disease duration and severity, were found in all the patients, including those with juvenile parkinsonism. These data may provide a basis for introducing cytochemical monitoring as well as for administration of modern "mitochondrial" drugs (yantavit, coenzyme Q10, L-carnitine, etc).
Polevaia
E V
EV
Ivanova-Smolenskaia
I A
IA
Illarioshkin
S N
SN
Sukhorukov
V S
VS
Markova
E D
ED
D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D028361:Mitochondrial Diseases / Q000150:complications*; D010300:Parkinson Disease / Q000150:complications* / Q000473:pathology*