Reanalysis of genotype distributions published in "Neurology" between 1999 and 2002.
The authors tested 123 genotypes described in 54 papers published in the journal Neurology between 1999 and 2002 to ascertain whether these genotype distributions deviated from Hardy-Weinberg equilibrium (HWE). Unreported deviations from HWE in 19 genotype distributions described in 11 of the papers were discovered. The authors also report additional information that could have been extracted after calculating HWE and conclude that HWE values should be mandatory in population genetic studies published in Neurology.
Kocsis
István
I
First Department of Pediatrics, Semmelweis University, Budapest, Hungary. kopist@gyer1.sote.hu
Vásárhelyi
Barna
B
Györffy
András
A
Györffy
Balázs
B
D000465:Algorithms; D000483:Alleles; D015706:Bibliometrics; D016022:Case-Control Studies; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D008957:Models, Genetic; D009462:Neurology; D011643:Publishing / Q000592:standards