Successful treatment for squamous cell carcinoma of the female urethra with combined radio- and chemotherapy.
We report on two cases of women with locally advanced squamous cell carcinoma of the urethra. Patient 1 also displayed regional lymph node metastasis. Treatment comprised combined radiotherapy to 60 Gy and chemotherapy with 5-fluorouracil and cisplatin. Complete response was obtained in both patients, including the inguinal lymph nodes of Patient 1. Patient 1 experienced recurrent inguinal lymph node metastasis on the contralateral side at 42 months after initial treatment, and the same treatment was performed followed by surgical excision. Both patients remain alive with no evidence of disease, at 12 months after recurrence in Patient 1, and at 27 months after treatment in Patient 2.
Division of Urology, Kobe University Graduate School of Medicine, Kobe 650-0071, Japan. hara@med.kobe-u.ac.jp
Isao
I
Hara
Satoko
S
Hikosaka
Hiroshi
H
Eto
Hideaki
H
Miyake
Yuji
Y
Yamada
Toshinori
T
Soejima
Kazuro
K
Sugimura
Sadao
S
Kamidono
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D014523:Urethral Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*
D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil