Lack of activity of orally administered clofazimine against intracellular Mycobacterium tuberculosis in whole-blood culture.
The activity of oral clofazimine against intracellular Mycobacterium tuberculosis was compared to that of ofloxacin in healthy volunteers by the use of whole-blood cultures. Clofazimine was inactive whether it was tested alone or combined with other drugs that are used to treat multidrug-resistant tuberculosis, despite a total dose of 2 g. Kanamycin was the most active drug tested.
University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA.
Ernestas
E
Janulionis
Carolina
C
Sofer
Ho-Yeon
HY
Song
Robert S
RS
Wallis
D000890:Anti-Infective Agents / Q000494:pharmacology; D000995:Antitubercular Agents; D019540:Area Under Curve; D001769:Blood / Q000382:microbiology; D002478:Cells, Cultured; D002991:Clofazimine / Q000097:blood / Q000494:pharmacology*; D015169:Colony Count, Microbial; D024901:Drug Resistance, Multiple, Bacterial; D004977:Ethambutol / Q000494:pharmacology; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D015242:Ofloxacin / Q000494:pharmacology; D011718:Pyrazinamide / Q000494:pharmacology; D015610:Serum Bactericidal Test
D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D015242:Ofloxacin; D002991:Clofazimine