Estrogen replacement therapy: effects on the cognitive functioning and clinical course of women with Alzheimer's disease.
This study examined the effects of unopposed estrogen replacement therapy (ERT) on the cognition and clinical course of women who have been diagnosed with probable Alzheimer's disease. The records of 99 women diagnosed with probable Alzheimer's disease according to NINCDS-ADRDA criteria, and in some cases autopsy confirmed as well, were analyzed. Depression, education, and age were all considered in the analysis. Results suggest that after an average of four years after symptoms appeared, women on ERT at the time of their diagnoses had similar cognitive functioning compared to those who are not on ERT. There were, however, significant differences in the clinical course of the illness between the two groups, with the non-ERT group reporting more "non-memory" problems as initial symptoms in addition to a having greater degree of overall behavioral deficit in activities of daily living.
Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Room C8-747/NPI, Los Angeles, CA 90024-1759, USA. ajlevine@mednet.ucla.edu
Andrew J
AJ
Levine
Matthew
M
Battista
D000203:Activities of Daily Living / Q000145:classification / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D018450:Disease Progression; D015914:Estrogen Replacement Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D017063:Outcome Assessment, Health Care; D011594:Psychometrics; D012016:Reference Values