Graves' disease accompanied by anti-myeloperoxidase antibody-related nephropathy and autoimmune hepatitis.
A 17-year-old woman was admitted because of proteinuria, microhematuria and liver dysfunction with increased antinuclear antibody and anti-myeloperoxidase antibody (MPO-ANCA). Fourteen months' previously, urinalysis and liver function showed normal range. At that time she suffered from tachycardia and weight reduction, diagnosed as Graves' disease, she was given propylthiouracil for treatment of her Graves' disease. The histological finding of renal biopsy was compatible with minor glomerular abnormalities. Liver biopsy finding was compatible with autoimmune hepatitis. After we had administered prednisolone, liver function returned to normal range and urine protein became negative. Then we performed subtotal thyroidectomy, and she was not given propylthiouracil. MPO-ANCA decreased gradually.
Department of Internal Medicine, Public Tomioka General Hospital, Tomioka.
Takashi
T
Nagai
Makoto
M
Imamura
Yuji
Y
Kamiya
Masatomo
M
Mori
D000293:Adolescent; D013956:Antithyroid Agents / Q000009:adverse effects; D001323:Autoantibodies / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D019693:Hepatitis, Autoimmune / Q000276:immunology*; D006801:Humans; D009393:Nephritis / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D009195:Peroxidase / Q000276:immunology*; D011441:Propylthiouracil / Q000009:adverse effects; D016896:Treatment Outcome
D013956:Antithyroid Agents; D001323:Autoantibodies; D011441:Propylthiouracil; D009195:Peroxidase