A decade of living lobar lung transplantation: perioperative complications after 253 donor lobectomies.
Living lobar lung transplantation places two donors at risk for each recipient. We examined the perioperative outcomes associated with the 253 donor lobectomies performed at our institution during our first decade of living lobar lung transplantation. There have been no perioperative or long-term deaths. 80.2% of donors (n = 203) had no perioperative complications, while fifty (19.8%) had one or more complication. The incidence of intraoperative complications was 3.6%. Complications requiring reoperation occurred in 3.2% of donors. 15.0% of donors had other perioperative complications; the most serious were two donors who developed pulmonary artery thrombosis, while the most common was the need for an additional thoracostomy tube or a thoracostomy tube for >/=14 d for persistent air leaks and/or drainage. Right-sided donors were more likely to have a perioperative complication than left-sided donors (odd ratio 2.02, p = 0.04), probably secondary to right lower and middle lobe anatomy. This experience has shown donor lobectomy to be associated with a relatively low morbidity and no mortality, and is important if this procedure is to be considered an option at more pulmonary transplant centers, given continued organ shortages and differences in philosophical and ethical acceptance of live
Department of Cardiothoracic Surgery, University of Southern California Keck School of Medicine and Childrens Hospital Los Angeles, Los Angeles, CA, USA.
Michael E
ME
Bowdish
Mark L
ML
Barr
Felicia A
FA
Schenkel
Marlyn S
MS
Woo
Ross M
RM
Bremner
Monica V
MV
Horn
Craig J
CJ
Baker
Richard G
RG
Barbers
Winfield J
WJ
Wells
Vaughn A
VA
Starnes
D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D019520:Living Donors; D008168:Lung / Q000473:pathology*; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009926:Organ Preservation / Q000379:methods; D011013:Pneumonectomy / Q000379:methods; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012306:Risk; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome