A lipid-peptide microbicide inactivates herpes simplex virus.
A microbicide combining the lipid-ether 1-0-octyl-sn-glycerol (OG; 3 mM) and peptide D2A21 (9 microM) reduced herpes simplex virus type 1 (HSV-1) and HSV-2 titers by at least 1,000-fold, more than the sum of the inactivations produced by OG and D2A21 alone. OG plus D2A21 reduced HSV-1 and HSV-2 titers by > or =1,000-fold in < or =10 and < or =20 min, respectively, whereas OG and D2A21 used alone produced almost no virus inactivation during these times.
New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Biochemistry, Staten Island, New York 10314, USA. chisi@cunyvm.cuny.edu
Charles E
CE
Isaacs
Jun Hua
JH
Jia
Weimin
W
Xu
D023181:Antimicrobial Cationic Peptides; D000998:Antiviral Agents / Q000494:pharmacology*; D004338:Drug Combinations; D005995:Glyceryl Ethers / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D010455:Peptides / Q000494:pharmacology*
C490932:1-O-octyl-sn-glycerol; D023181:Antimicrobial Cationic Peptides; D000998:Antiviral Agents; C430264:D2A21; D004338:Drug Combinations; D005995:Glyceryl Ethers; D010455:Peptides