Antioxidant phenolic and quinonemethide triterpenes from Cheiloclinium cognatum.
The triterpenes, 22beta-hydroxypristimerin and cognatine, were isolated together with the known compounds pristimerin, maytenin, 20alpha-hydroxymaytenin, 22beta-hydroxymaytenin, netzahualcoyol, netzahualcoyondiol and netzahualcoyone from root bark of Cheiloclinium cognatum. The structures of the isolated compounds were elucidated by interpretation of their spectral data, including gHMQC and gHMBC experiments. The isolates were investigated for their radical scavenging abilities through a spectrophotometric assay involving reduction of 2,2-diphenyl-picryl hydrazyl (DPPH).
Jeller
Alex Haroldo
AH
Departamento de Química, Universidade Estadual de Mato Grosso do Sul, CP 351, 79804-970 Dourados, MS, Brazil.
Silva
Dulce Helena Siqueira
DH
Lião
Luciano Morais
LM
Bolzani
Vanderlan da Silva
Vda S
Furlan
Maysa
M
D000975:Antioxidants / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D016166:Free Radical Scavengers / Q000737:chemistry; D031320:Hippocrateaceae / Q000737:chemistry* / Q000145:classification; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
C494170:22 beta-hydroxypristimerin; D000975:Antioxidants; D016166:Free Radical Scavengers; D014315:Triterpenes; C494167:cognatine