Intermittent hyperammonemic encephalopathy in a child with ornithine transcarbamylase deficiency.
Ornithine transcarbamylase (OTC) deficiency is an X-linked disorder and the most common inherited cause of hyperammonemia. Clinical manifestations are more severe in hemizygous males who often present in neonatal period. Heterozygous females may be asymptomatic until juvenile or adulthood. Fluctuating concentration of ammonia, glutamine and other excitotoxic amino acids result in a chronic or episodically recurring encephalopathy. The authors report a heterozygous female with OTC deficiency who presented with recurrent encephalopathy.
Gulati
Sheffali
S
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. sheffalig@yahoo.com
Menon
Shaji
S
Kabra
Madhulika
M
Kalra
Veena
V
D001928:Brain Diseases, Metabolic / Q000178:diet therapy / Q000209:etiology*; D002675:Child, Preschool; D018753:Diet, Protein-Restricted; D005260:Female; D006801:Humans; D022124:Hyperammonemia / Q000178:diet therapy / Q000209:etiology*; D020163:Ornithine Carbamoyltransferase Deficiency Disease / Q000150:complications*