Modulation of the arachidonic cascade with omega3 fatty acids or analogues: potential therapeutic benefits.
Increasing interest in the role of omega3 fatty acids has arisen in these latest years since evidence of their implication in the cardioprotective fish based diet of the Inuit has been demonstrated. Furthermore, several in vitro, in vivo and epidemiological studies support the benefit of this fatty acids intake in various pathological states such as in the cardiovascular, cancer, inflammation, psychiatric, paediatric, pulmonary, dermatological and ophthalmologic fields. This review will focus on metabolism and pharmacological implication of omega3 fatty acids intake as well as its interest in the prevention or treatment of the above-mentioned pathologies.
Roland
Isabelle
I
Laboratory of Pharmaceutical Technology, Institute of Pharmacy, University of Liège, avenue de l'Hôpital, 1, B36, Sart Tilman, B- 4000 Liège, Belgium. iroland@ulg.ac.be
De Leval
Xavier
X
Evrard
Brigitte
B
Pirotte
Bernard
B
Dogné
Jean-Michel
JM
Delattre
Luc
L
D016718:Arachidonic Acid / Q000737:chemistry / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D015777:Eicosanoids / Q000096:biosynthesis; D005128:Eye Diseases / Q000517:prevention & control; D015525:Fatty Acids, Omega-3 / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D008084:Lipoxygenase / Q000378:metabolism; D008171:Lung Diseases / Q000517:prevention & control; D009422:Nervous System Diseases / Q000517:prevention & control; D011247:Pregnancy; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D015398:Signal Transduction; D012871:Skin Diseases / Q000517:prevention & control
D015777:Eicosanoids; D015525:Fatty Acids, Omega-3; D016718:Arachidonic Acid; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases