Acute and chronic ethanol does not affect incisional pain in neonatal rats.
We have previously found that in post-natal day 7 rats withdrawal from acute and chronic ethanol (EtOH) exposure lowers mechanical thresholds during withdrawal and exacerbates spontaneous pain responses to an inflammatory injury 4 days post-withdrawal. These findings suggested alterations in somatosensory pathways following EtOH exposure during the third trimester developmental equivalent. In this study we wanted to determine whether EtOH exposure during the third trimester equivalent exacerbates mechanical allodynia and thermal hyperalgesia produced by an incisional model of post-operative pain at post-natal day 21. The extent and duration of mechanical allodynia and thermal hyperalgesia following incision was measured and found to be unaffected by prior EtOH exposure.
Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jennifer A
JA
Shumilla
Sarah M
SM
Sweitzer
Joan J
JJ
Kendig
D000818:Animals; D000831:Animals, Newborn; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006930:Hyperalgesia / Q000503:physiopathology; D010147:Pain Measurement / Q000187:drug effects*; D010149:Postoperative Pain / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D002492:Central Nervous System Depressants; D000431:Ethanol