Evaluation of Fas gene promoter polymorphism in cervical cancer patients.
Transduction of signalling through Fas receptor has been implicated in physiological regulation of apoptosis process as well as pathogenesis of various human diseases. The gene encoding Fas receptor contains single nucleotide polymorphism at -670 position, which influences the expression by different transcriptional efficiency of this gene. The aim of this study was to determine the distribution of -670 A/G Fas gene promoter polymorphism in cervical cancer patients and healthy control group in Poland in order to evaluate the potential association between Fas genotype and cervical carcinogenesis. Our results do not confirm the hypothesis that AA genotype in Fas gene promoter may be engaged in the development of cervical neoplasia.
Department of Biotechnology, Intercollegiate Faculty of Biotechnology, 80-822 Gdansk, Poland. dybikows@biotech.univ.gda.pl
Aleksandra
A
Dybikowska
Wojciech
W
Sliwinski
Janusz
J
Emerich
Anna J
AJ
Podhajska
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000378:metabolism; D004279:DNA, Viral / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005843:Geography; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D019014:fas Receptor / Q000235:genetics*
D004273:DNA, Neoplasm; D004279:DNA, Viral; D019014:fas Receptor