[Discovery of susceptibility gene for coronary heart disease].
Coronary heart disease (CHD) is a leading cause of death for adults in many countries. It is multifactorial in origin with both genetic and environmental factors contributing to its development. But the molecular basis of CHD pathogenesis remains obscure, which represents a major obstacle to the identification of CHD susceptibility genes. Knowledge of genetic factors contributing to the pathogenesis of CHD will undoubtedly advance efforts to identify CHD susceptibility genes. The benefits promised are great, but progress to gene identification in CHD has been rather disappointing so far. This review aims to discuss the current and future approaches to gene discovery in CHD. And these approaches can be applied equally to other multifactorial traits in the cardiovascular arena--stroke, peripheral arterial occlusive disease, hypertension, heart failure and beyond.
Shang
Hai-Hui
HH
Ruijin Hospital, SSMU, Shanghai 200025.
D003327:Coronary Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D020641:Polymorphism, Single Nucleotide