Electrocardiographic predictors of arrhythmic death and total mortality in the multicenter unsustained tachycardia trial.
BACKGROUND
Stratifiers of sudden and total mortality risk are needed to optimally target preventive therapies in patients with coronary artery disease and impaired ventricular function. We assessed the prognostic significance of ECG markers of conduction abnormalities and left ventricular hypertrophy in the Multicenter Unsustained Tachycardia Trial (MUSTT).


RESULTS
We analyzed the ECGs of 1638 patients from MUSTT who did not receive antiarrhythmic therapy (antiarrhythmic medication or implantable cardioverter-defibrillator). After adjustment for other significant factors, left bundle-branch block and intraventricular conduction delay were associated with a 50% increase in the risk of both arrhythmic and total mortality. Right bundle-branch block was not associated with arrhythmic or total mortality. Left ventricular hypertrophy was the only ECG predictor of arrhythmic (hazard ratio, 1.35; 95% CI, 1.08 to 1.69) but not total mortality.


CONCLUSIONS
In patients with coronary artery disease, depressed left ventricular function, and nonsustained ventricular tachycardia, QRS prolongation resulting from left bundle-branch block or intraventricular conduction delay but not right bundle-branch block provided prognostic information about the risk of arrhythmic and total mortality independently of electrophysiological evaluation and ejection fraction. Left ventricular hypertrophy was associated with increased arrhythmic but not total mortality.
Zimetbaum
Peter J
PJ
Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Boston, Mass 02215, USA. pzimetba@BIDMC.harvard.edu
Buxton
Alfred E
AE
Batsford
William
W
Fisher
John D
JD
Hafley
Gail E
GE
Lee
Kerry L
KL
O'Toole
Michael F
MF
Page
Richard L
RL
Reynolds
Matthew
M
Josephson
Mark E
ME
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000401:mortality* / Q000503:physiopathology; D002037:Bundle-Branch Block / Q000453:epidemiology / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D002423:Cause of Death; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D006323:Heart Arrest / Q000453:epidemiology / Q000209:etiology; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000401:mortality / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012306:Risk; D016037:Single-Blind Method; D013610:Tachycardia / Q000401:mortality / Q000503:physiopathology; D014481:United States / Q000453:epidemiology