The emerging role of therapeutic botulinum toxin in the treatment of cerebral palsy.
Therapeutic injections of botulinum toxin have been used for the past decade to decrease muscle tone in children with cerebral palsy. Although this unique intervention has been shown to provide safe localized spasticity reduction, functional benefits have been more difficult to demonstrate. Appropriate selection of patients and clearly defined goals are key factors in the success of a treatment program. The therapeutic approach to treating children with cerebral palsy should include a variety of complementary interventions that address the effect of abnormal muscle tone on the abilities of these children as they grow and develop.
Kennedy Krieger Institute and Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA. pidcock@kennedyk-rieger.org
Frank S
FS
Pidcock
D000203:Activities of Daily Living; D018726:Anti-Dyskinesia Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D019274:Botulinum Toxins, Type A; D002547:Cerebral Palsy / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D019317:Evidence-Based Medicine; D006801:Humans; D007273:Injections, Intramuscular; D009128:Muscle Spasticity; D009937:Organizational Objectives; D010347:Patient Care Planning / Q000458:organization & administration; D018579:Patient Selection; D026741:Physical Therapy Modalities; D011788:Quality of Life; D016059:Range of Motion, Articular; D012449:Safety; D016896:Treatment Outcome
D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A