Serum cytokine concentrations in alcohol-dependent individuals without liver disease.
In the current study, our aim was to evaluate and investigate the influence of heavy alcohol intake on serum interleukin (IL)-6, IL-8, IL-10, IL-12, and tumor necrosis factor-alpha (TNF-alpha) concentrations. The selection of cytokines was based on their presumptive role in the pathophysiology of alcohol dependence. On admission to the Drug-Free Substance Addiction Detoxification clinic ("ATHENA"), blood samples were obtained from study participants, and serum cytokine concentrations were measured by using a commercial sandwich enzyme-linked immunosorbent assay technique. Alcohol dependence, as diagnosed according to DSM-IV [Diagnostic and Statistical Manual of Mental Disorders (4th ed.)] criteria for alcohol dependence and estimated by using the Composite International Diagnostic Interview (CIDI), was characterized by increased serum IL-6 concentration. Interleukin-8, IL-10, IL-12, and TNF-alpha concentrations were comparable to those found in control subjects (P>.05). These results indicate that in alcohol-dependent individuals there is a significant increase in the serum IL-6 concentration (P <.05).
Athens Medical School-Aeginition Hospital, Department of Biopathology, Vass Sophias av. 72-74, 115 28 Athens, Greece.
Chryssoula
C
Nicolaou
Stylianos
S
Chatzipanagiotou
Dimitrios
D
Tzivos
Elias Odusseas
EO
Tzavellas
Fotini
F
Boufidou
Ioannis Alexandros
IA
Liappas
D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008108:Liver Diseases, Alcoholic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D016207:Cytokines; D015850:Interleukin-6