Homologous recombination: down to the wire.
Exchange of strands between homologous DNA molecules is catalyzed by evolutionarily conserved recombinases. These proteins can occur in different quaternary arrangements: rings or helical filaments. Recent results reveal that recombinase function follows from the filamentous form.
Wyman
Claire
C
Department of Cell Biology & Genetics, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands. c.wyman@erasmusmc.nl
Kanaar
Roland
R
D000255:Adenosine Triphosphate / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D008956:Models, Chemical; D011487:Protein Conformation; D011938:Rec A Recombinases / Q000737:chemistry / Q000378:metabolism*; D011995:Recombination, Genetic
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D000255:Adenosine Triphosphate; D004247:DNA; D011938:Rec A Recombinases