Cell surface molecules and truncal neural crest ontogeny: a perspective.
The neural crest cell is synonymous with vertebrates and can be viewed as a transitory, mobile vector that conveys neuroepithelial stem cells to a diverse number of remote locations in the embryo. Neural crest cells have been studied intensively over the past 30 years, and it is increasingly apparent that their fate is, at least in part, directed extrinsically by the environment to which they are exposed in vivo. The interface between the cell surface and the opposing environment is clearly an important compartment for the correct deployment of the neural crest. Here, we review some of the molecules present in this location and how they influence the fate of the neural crest and generate disease.
Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. robert.moore@fccc.edu
Robert
R
Moore
Lionel
L
Larue
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion; D019070:Cell Lineage; D002462:Cell Membrane / Q000378:metabolism*; D017630:Connexins / Q000378:metabolism; D004628:Embryonic Structures / Q000502:physiology; D036342:Ephrins / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D016023:Integrins / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism; D008954:Models, Biological; D009432:Neural Crest / Q000196:embryology* / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D013997:Time Factors
D015820:Cadherins; D017630:Connexins; D036342:Ephrins; D016023:Integrins; D011505:Protein-Tyrosine Kinases