Biofilm formation in vitro and virulence in vivo of mutants of Klebsiella pneumoniae.
One of the early stages of Klebsiella pneumoniae airway infections may involve biofilm formation. Bacterial biofilm formation is frequently investigated using in vitro techniques that facilitate identification and analysis of individual genes. We investigated the correlation between K. pneumoniae biofilm formation in vitro and ability to cause infection in vivo following construction of a bank of mini-Tn5 mutants.
Lavender
Heather F
HF
Department of Microbiology, College of Medicine, University of Iowa, Iowa City, 52242, USA.
Jagnow
Jennifer R
JR
Clegg
Steven
S
D000818:Animals; D018441:Biofilms / Q000254:growth & development*; D004251:DNA Transposable Elements; D004195:Disease Models, Animal; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology / Q000503:physiopathology; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D051379:Mice; D016254:Mutagenesis, Insertional; D009154:Mutation; D014774:Virulence
D004251:DNA Transposable Elements