Genotyping of human giardiasis in relation to anti-Giardia secretory IgA and mucosal histopathology.
Comparative study between the prevalence of pathological grading and Giardia genotypes revealed that, in patients infected with Giardia group I and II, out of patients having Giardia genotype I the prevalence of grade 0 was 13.16%, grade I was 21.05%, grade II was 47.37%, grade III was 13.16% and grade IV was 2.26% in comparison to 0%, 30.77%, 46.15%, 7.69% and 15.38% in genotype II (13 patients) and 10%, 40%, 20%, 20% and 10% in group III (10 patients) also in relation to 25%, 43.75%, 18.75%, 6.25% and 6.25% in mixed genotype infections group (16 patients) and 25%, 25%, 35.71%, 10.71% and 3.57% in undetermined infection group (28 patients) for grade 0, I, II, III & IV pathology respectively. There was no statistically significant difference regarding the prevalence of pathological grading in different Giardia genotypes in Gs I & II (P > 0.05). The mean OD of anti-Giardia secretory IgA in relation to Giardia genotypes in patients infected with Giardia Gs I & II was significantly different in the mean OD values of anti-Giardia secretory IgA in patients with different Giardia genotypes which were 1.091 +/- 0.377, 1.079 +/- 0.474, 1.524 +/- 0.503, 1.292 +/- 0.472 & 1.004 +/- 0.31 groups of genotype I, II, III, mixed genotypes infection and undetermined infection group respecttively (P > 0.05), being more increased in patients infected with Giardia genotype III and in mixed genotype infection.
Department of Medicine, Faculty of Medicine, Mansoura University, Egypt.
Hassan
H
Risk
Atef M
AM
el-Shazly
Mohamad
M
Soliman
Anhar A
AA
Mohamad
Eman M A
EM
el-Sharkawy
Ayman T A
AT
Morsy
D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology / Q000378:metabolism; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics; D005260:Female; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D005838:Genotype; D016829:Giardia lamblia / Q000145:classification / Q000235:genetics*; D005873:Giardiasis / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D000913:Antibodies, Protozoan; D016054:DNA, Protozoan; D007071:Immunoglobulin A, Secretory