Evaluation of a mucoactive herbal drug, Radix Ophiopogonis, in a pathogenic quail model.
We investigated the effect of Radix Ophiopogonis on airway mucociliary clearance and mucus secretion in anesthetized quails. The oral administration of 10 g/kg of Radix Ophiopogonis significantly increased tracheal mucociliary transport velocity (MTV). Moreover, either 10 g/kg or 3 g/kg of Radix Ophiopogonis markedly attenuated the human neutrophil elastase (HNE)-induced decrease in MTV. Furthermore, we found that 10 g/kg of Radix Ophiopogonis significantly abolished the HNE-induced increases in fucose and protein contents of tracheal lavage, whereas Radix Ophiopogonis at the same dose only significantly decreased the protein content in the control group. These results suggest that Radix Ophiopogonis improves airway mucociliary clearance and that the improvement may, at least in part, be ascribed to the amelioration of airway mucus secretion.
173 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Shusheng
S
Tai
Feng
F
Sun
Darryl W
DW
O'Brien
Megan S
MS
Lee
J Gustavo
JG
Zayas
Malcolm
M
King