Major hypertriglyceridemia in HIV-infected patients on antiretroviral therapy: a role of the personal and family history.
BACKGROUND
Our aim was to identify factors predisposing HIV-infected patients on long-term antiretroviral therapy (ART) to major hypertriglyceridemia (HTG).


METHODS
We conducted a retrospective, case-control study involving 76 HIV-infected patients with HTG, defined by 12-hour fasting plasma triglyceride (TG) > 4.5 mmol/l on at least one occasion, and 150 HIV-infected matched control patients with TG consistently below 1.8 mmol/l.


RESULTS
Patients coinfected by the hepatitis C virus appeared to be protected from HTG. In addition to known predisposing factors for HTG in HIV-infected patients (ART and immune/viral status), patients with a history of excess body weight were twice as likely to have HTG (odds ratio [OR] 2.8, 95% confidence interval [CI]: 1.1-6.9); HTG was also more frequent in patients who had a first-degree relative with cardiovascular disease (CVD) or a major risk factor for CVD (OR = 3.6, CI: 1.3-9.9).


CONCLUSIONS
By identifying subgroups of highly predisposed patients, appropriate lifestyle and dietary measures could be recommended on ART initiation.
Bollens
D
D
Infectious Diseases Unit, Saint Antoine Hospital, 184 rue du Faubourg, Saint-Antoine, 75571, Paris Cedex 12, France.
Guiguet
M
M
Tangre
P
P
Rollinat
L
L
Rachline
A
A
Meynard
J L
JL
Girard
P M
PM
Benlian
P
P
Meyohas
M C
MC
D000328:Adult; D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D015992:Body Mass Index; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000209:etiology; D008019:Life Style; D008297:Male; D008487:Medical History Taking; D010375:Pedigree; D012189:Retrospective Studies; D012307:Risk Factors
D044966:Anti-Retroviral Agents