Practical considerations in the administration of intravenous vasoactive drugs in the critical care setting. Part II--how safe is our practice?
BACKGROUND
Vasoactive drugs (e.g. inotropes), namely adrenaline and noradrenaline, are frequently used in critical care to maintain cardiovascular function. This is achieved by ensuring that a continuous infusion of the vasoactive drug is administered so that when one infusion is about to finish another infusion is commenced. This is known as "double pumping" or "piggy backing". Failure to administer these drugs appropriately may result in haemodynamic instability (hypotension and hypertension) and in extreme cases death.


OBJECTIVE
The aim of this study was to evaluate current practice and identify the safest method for inotrope administration.


METHODS
A series of three consecutive audits were undertaken to determine which 'Method' and 'Syringe Driver' were associated with the least adverse effects to patient blood pressure.


RESULTS
The findings suggest that Modified Method 2, when used in conjunction with a high-risk syringe driver and guidelines, proved to be the safest method for 'double pumping' inotrope drugs. Modified Method 2 instructed nurses to: 'Run both syringe drivers together until a rise in systolic blood pressure is seen (>5 mmHg), then turn the near empty infusion off'.


CONCLUSIONS
As a direct result of these audits, and the development of guidelines, inotrope administration practice on the unit has improved.
Morrice
Amanda
A
General Critical Care, St Georges Healthcare NHS Trust, St Georges Hospital, London SW17 0QT, UK. amanda.morrice@stgeorges.nhs.uk
Jackson
Emma
E
Farnell
Sarah
S
D002316:Cardiotonic Agents / Q000008:administration & dosage*; D006439:Hemodynamics; D006801:Humans; D007262:Infusions, Intravenous / Q000295:instrumentation / Q000379:methods* / Q000451:nursing; D009731:Nursing Audit; D017410:Practice Guidelines as Topic; D017751:Safety Management; D013594:Syringes; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
D002316:Cardiotonic Agents; D014662:Vasoconstrictor Agents