[Role of NO-mediated mechanisms in post-irradiation changes of neurohormonal regulation of the heart function].
Investigations on isolated Langendorff-perfused rat heart have shown that after the impact of ionizing radiation in 1 Gy dose the myocardial contractility and relaxation are decreased. The inhibition of NO synthesis attenuates chrono- and inotropic responses of the heart and reaction of coronary vessels to norepinephrine (NE), increases negative inotropic and vasoconstrictor effects of carbamylcholine (CCh). In the irradiated animals the reaction of isolated heart to NE and CCh is decreased. The post-irradiation changes in adreno- and cholinoreactivity caused not only by changes in receptor sensitivity and density, but also by impairment of NO-mediated regulation of coronary flow and biomechanical heart function.
L M
LM
Lobanok
T A
TA
Suvorova
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects; D006321:Heart / Q000187:drug effects / Q000528:radiation effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects / Q000528:radiation effects; D009206:Myocardium / Q000378:metabolism*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats
D000316:Adrenergic alpha-Agonists; D018679:Cholinergic Agonists; D004791:Enzyme Inhibitors; D018377:Neurotransmitter Agents; D009569:Nitric Oxide; D002217:Carbachol; D019331:NG-Nitroarginine Methyl Ester; D009638:Norepinephrine