Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so.
While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human V gamma 9/V delta 2 T cells.
Eberl
Matthias
M
Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. matthias.eberl@biochemie.med.uni-giessen.de
Hintz
Martin
M
Jamba
Zandraa
Z
Beck
Ewald
E
Jomaa
Hassan
H
Christiansen
Gunna
G
D000818:Animals; D011756:Diphosphates / Q000276:immunology* / Q000378:metabolism; D004896:Erythritol / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D009174:Mycoplasma / Q000276:immunology / Q000378:metabolism; D018661:Mycoplasma penetrans / Q000235:genetics / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D013403:Sugar Phosphates / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D013729:Terpenes / Q000378:metabolism
C114232:2-C-methylerythritol 4-phosphate; C443995:4-hydroxy-3-methylbut-2-enyl pyrophosphate; D011756:Diphosphates; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013403:Sugar Phosphates; D013729:Terpenes; D004896:Erythritol