Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study.
Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study.
Li
Yonghong
Y
Celera Diagnostics, Alameda, CA, USA.
Tacey
Kristina
K
Doil
Lisa
L
van Luchene
Ryan
R
Garcia
Veronica
V
Rowland
Charles
C
Schrodi
Steve
S
Leong
Diane
D
Lau
Kit
K
Catanese
Joe
J
Sninsky
John
J
Nowotny
Petra
P
Holmans
Peter
P
Hardy
John
J
Powell
John
J
Lovestone
Simon
S
Thal
Leon
L
Owen
Michael
M
Williams
Julie
J
Goate
Alison
A
Grupe
Andrew
A
D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D012333:RNA, Messenger