New aspects on the role of blood pressure and arterial stiffness in mechanical assistance by intra-aortic balloon pump: in-vitro data and their application in clinical practice.
Despite the well-known beneficial effects of the intra-aortic balloon pump (IABP) generally, there are still some clinical conditions accompanied by IABP ineffectiveness. The aim of this study was the investigation of the independent effects of arterial stiffness and blood pressure on acute IABP effectiveness. For this purpose, a mock circulatory system and 20 patients with cardiogenic shock due to acute myocardial infarction, were employed. It was shown that IABP acute efficiency was determined primarily by arterial compliance (AC) rather than blood pressure alone. IABP induced low hemodynamic effects in patients with systolic blood pressure > 80 mm Hg but with increased AC, whereas IABP resulted in greater hemodynamic effectiveness in cases with systolic pressure < 70 mm Hg but lower AC. The present study provides evidence concerning the hemodynamic conditions, which might lead to optimization of IABP or to the prediction of its acute hemodynamic performance, based on both measurements of AC and blood pressure.
Laboratory of Biofluid Mechanics and Biomedical Technology, Fluids Section, School of Mechanical Engineering, National Technical University of Athens, Athens, Greece. theopap@mail.ntua.gr
Theodoros G
TG
Papaioannou
Dimitrios S
DS
Mathioulakis
Kimon S
KS
Stamatelopoulos
Elias J
EJ
Gialafos
John P
JP
Lekakis
John
J
Nanas
Stamatios F
SF
Stamatelopoulos
Sokratis G
SG
Tsangaris
D000368:Aged; D001158:Arteries / Q000502:physiology / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D003187:Compliance; D004868:Equipment Failure; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000150:complications; D012770:Shock, Cardiogenic / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*