Inhibition of melanoma metastases by fenofibrate.
The effect of fenofibrate, a ligand of peroxisome proliferator-activated receptor (PPAR) alpha, on the growth and metastatic potential of Bomirski hamster melanoma s.c. tumors, pigmented line (BHM Ma) was investigated in vivo. RT-PCR and Western-blot analyses revealed the presence of mRNA and protein of PPAR alpha in BHM Ma cells. The animals treated orally with fenofibrate developed significantly fewer metastatic foci in the lungs, as compared to the control group; however, primary tumor growth remained unaltered. This observation is interesting in respect of the potential use of fenofibrate in melanoma chemoprevention.
Grabacka
Maja
M
Faculty of Biotechnology, Jagiellonian University, ul. Gronostajowa 7, Krakow, Poland. chwast@temple.edu
Placha
Wojciech
W
Plonka
Przemyslaw M
PM
Pajak
Stanislawa
S
Urbanska
Krystyna
K
Laidler
Piotr
P
Slominski
Andrzej
A
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001483:Base Sequence; D006224:Cricetinae; D005260:Female; D011345:Fenofibrate / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008024:Ligands; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control / Q000556:secondary; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000556:secondary; D008647:Mesocricetus; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
D000970:Antineoplastic Agents; D000960:Hypolipidemic Agents; D008024:Ligands; D047493:PPAR alpha; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011345:Fenofibrate