The use of polymers for dermal and transdermal delivery.
The use of polymers for skin preparations is manifold. Requirements of such polymers are dependent on the formulation types. The most applied polymers on skin belong to various classes, for example to cellulose derivatives, chitosan, carageenan, polyacrylates, polyvinylalcohol, polyvinylpyrrolidone and silicones. They are gelating agents, matrices in patches and wound dressings, anti-nucleants and penetration enhancers. Correlations between commercially available products and results of new scientific investigations are often difficult or not possible, because of the lack of comparative data especially for transdermal patches. Finally, two promising future trends of polymeric systems, gene delivery and tissue engineering, are discussed.
Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria. claudia.valenta@univie.ac.at
Claudia
C
Valenta
Barbara G
BG
Auner
D000277:Adjuvants, Pharmaceutic / Q000737:chemistry; D000279:Administration, Cutaneous; D000818:Animals; D001458:Bandages; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D006801:Humans; D009824:Ointments / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry*; D012869:Skin Absorption; D012871:Skin Diseases / Q000188:drug therapy
D000277:Adjuvants, Pharmaceutic; D004655:Emulsions; D005782:Gels; D009824:Ointments; D004364:Pharmaceutical Preparations; D011108:Polymers