Determination of tackiness of chitosan film-coated pellets exploiting minimum fluidization velocity.
The tackiness of aqueous chitosan film coatings and effects of anti-sticking agents on sticking tendency, were evaluated. A novel rapid method exploiting minimum fluidization velocity to determine tackiness was introduced and tested. The pressure difference over the miniaturized fluidized-bed was precisely recorded as a function of velocity of fluidization air. High molecular weight chitosan plasticized with glycerol was used as a film-forming agent. Magnesium stearate, titanium dioxide, colloidal silicon dioxide and glyceryl-1-monostearate (GMS) were studied as anti-sticking agents. Film coatings were performed in a miniaturized top-spray coater. The incorporation of anti-sticking agents led to a clear decrease in tackiness of the chitosan films, and magnesium stearate and GMS were shown the most effective. Film-coated pellets containing magnesium stearate and GMS as an anti-sticking agent were very easily fluidized (showing very low values of minimum fluidization velocity) and were thus classified as the best flowing and the least sticking samples. Both these additives were found anti-sticking agents of choice for aqueous chitosan film coatings. Determination of the experimental minimum fluidization velocity in a fluidized bed, is a useful and sensitive method of measuring the tackiness tendency of film-coated pellets.
Institute of Pharmacy and Food, University of Havana, Cuba.
M
M
Fernández Cervera
J
J
Heinämäki
E
E
Räsänen
O
O
Antikainen
O M
OM
Nieto
A
A
Iraizoz Colarte
J
J
Yliruusi
D000268:Adhesiveness; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D048271:Chitosan / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D003692:Delayed-Action Preparations; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005989:Glycerides / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
D003692:Delayed-Action Preparations; D005989:Glycerides; D013229:Stearic Acids; C009495:titanium dioxide; C048159:glyceryl monostearate; C031183:stearic acid; D012822:Silicon Dioxide; D002482:Cellulose; D048271:Chitosan; D014025:Titanium; D005990:Glycerol