Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides.
Novel pyrazolo[3,4-b]indole nucleoside analogs were synthesized from the corresponding 3-formyl-2-chloroindole and 3-cyano-2-chloroindole nucleosides by treatment with hydrazine. Very few examples of pyrazolo[3,4-b]indole heterocycles have been published in the literature and this is the first synthesis of nucleoside analogs containing this heterocycle. These new pyrazolo[3,4-b]indole nucleosides were active against human cytomegalovirus and herpes simplex virus type 1, but this activity was not well separated from cytotoxicity.
Department of Medicinal Chemistry, College of Pharmacy University of Michigan, Ann Arbor, Michigan 48109-1078, USA.
John D
JD
Williams
John C
JC
Drach
Leroy B
LB
Townsend
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D007211:Indoles; D009705:Nucleosides; D011720:Pyrazoles