Evaluation of zinc against salinomycin toxicity in broilers.
Salinomycin was studied for its toxicity and zinc (80 mg/kg) was assessed for prophylactic and therapeutic management in broiler chicks. Male broiler chicks were randomly divided into 7 groups consisting of 6 chicks in each. Group 1, 2 and 3 were maintained as control, therapeutic dose control (60 mg/kg feed) and toxic dose control (120 mg/kg feed), respectively. Group 4 was fed on feed containing salinomycin therapeutic dose and zinc. Group 5 received feed containing toxic dose of salinomycin. Group 6 and 7 were fed on feed containing toxic dose of salinomycin for the first 4 weeks for induction of ionophore toxicity and for the subsequent 2 weeks, group 6 received zinc and group 7 was fed on feed containing toxic dose of salinomycin along with zinc. Weekly body weights revealed a significant (P<0.01) decrease in toxic controls as compared to group 1, 2, 4 and 5. The activity of glutathione peroxidase, glutathione reductase and catalase, and the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total proteins, total cholesterol, triglycerides, low density lipoproteins (LDL), urea, creatinine and blood urea nitrogen (BUN) were significantly (P<0.01) elevated in toxic controls, whereas glutathione (GSH) and high density lipoproteins (HDL) were significantly (P<0.01) lowered as compared to group 1, 2, 4 and 5. Following toxicity, zinc supplementation in group 6 and 7, all serobiochemical parameters were revived to normal. Thus, it is enunciated that salinomycin toxicity is due to oxidative damage and use of zinc in feed tends to cure and avoid any accidental toxicity.
Kamashi
K
K
Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad--500 030.
Reddy
A Gopala
AG
Reddy
K S
KS
Reddy
V R
VR
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001835:Body Weight; D002374:Catalase / Q000097:blood; D002645:Chickens / Q000502:physiology*; D003049:Coccidiostats / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D007677:Kidney Function Tests; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D011506:Proteins / Q000378:metabolism; D011714:Pyrans / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D015032:Zinc / Q000627:therapeutic use*; D000095662:Polyether Polyketides
D000975:Antioxidants; D002374:Catalase; D003049:Coccidiostats; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D008055:Lipids; D011506:Proteins; D011714:Pyrans; D015032:Zinc; C010327:salinomycin; D000095662:Polyether Polyketides