Two dimensional PNA/DNA arrays: estimating the helicity of unusual nucleic acid polymers.
We extend the generality of nucleic acid-based structural nanotechnology by incorporating non-natural nucleic acids into a DNA double crossover (DX) molecule; visualizing two-dimensional arrays of these DX molecules by Atomic Force Microscopy (AFM) enables us to measure the helical repeat of any heteroduplex sequence capable of forming the outer arms of a DX.
Lukeman
Philip S
PS
NYU Department of Chemistry, 31 Washington Place, New York, NY 10003, USA.
Mittal
Alexander C
AC
Seeman
Nadrian C
NC
D001483:Base Sequence; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D036103:Nanotechnology / Q000379:methods; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D020135:Peptide Nucleic Acids; D011108:Polymers; D004247:DNA