The administration of a multivitamin/mineral fortified dairy product improves folate status and reduces plasma homocysteine concentration in women of reproductive age.
OBJECTIVE
Folate deficiency during the periconceptional period is related to the occurrence and recurrence of neural tube defects. The aim of the study was to assess whether the administration of folic acid and other vitamins and minerals as a fortified dairy product (400 microg per day of folic acid) improves the folate status in women of reproductive age.


METHODS
Plasma and red blood cell folate, plasma vitamin E, B12, total plasma homocysteine, plasma lipid profile, and serum ferritin and transferrin levels were investigated in 31 healthy nonpregnant women receiving 500 mL/day of the fortified dairy product for eight weeks.


RESULTS
The women showed a significant increase in plasma levels of folate and vitamin B12 concentrations after four and eight weeks of supplementation. Moreover, we observed an increase in red blood cell folate concentration during the period of the study. Simultaneously, total plasma homocysteine levels decreased significantly during the intervention period.


CONCLUSIONS
The regular consumption of a folic acid and other vitamins (mainly vitamins B6 and B12) and minerals in a fortified dairy product improves folate status and reduces total plasma homocysteine concentration in healthy women of childbearing age.
Baró
Luis
L
PULEVA BIOTECH S.A., Camino de Purchil 66, 18004-Granada, Spain.
Martínez-Férez
Antonio
A
Rodríguez
Carlos
C
Valero
Antonio
A
Fonollá
Juristo
J
Lucena
Antonio
A
Jiménez
Jesús
J
Boza
Julio José
JJ
López-Huertas
Eduardo
E
D000328:Adult; D003611:Dairy Products; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood*; D005527:Food, Fortified; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008903:Minerals / Q000008:administration & dosage*; D010349:Patient Compliance; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000097:blood; D014815:Vitamins / Q000008:administration & dosage*
D008903:Minerals; D014815:Vitamins; D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12