Computational studies of membrane channels.
The determination of the structure of several members of the K+ channel and aquaporin family represents a unique opportunity to explain the mechanism of these biomolecular systems. With their ability to go beyond static structures, molecular dynamics simulations offer a unique route for relating functional properties to membrane channel structure. The recent progress in this area is reviewed.
Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA. benoit.roux@med.cornell.edu
Benoit
B
Roux
Klaus
K
Schulten
D000818:Animals; D020346:Aquaporins / Q000737:chemistry*; D006801:Humans; D007473:Ion Channels / Q000737:chemistry*; D008968:Molecular Conformation; D012984:Software; D013598:Systems Theory
D020346:Aquaporins; D007473:Ion Channels