[A case of brain metastasis of small cell lung cancer improved with nogitecan hydrochloride (topotecan) after prophylactic irradiation].
A 55-year old woman was treated with chemoradiotherapy for limited type small cell lung cancer. She was then treated with prophylactic cranial irradiation. However, local recurrence and metastatic brain tumors were detected after a year. Three courses of chemotherapy with nogitecan (topotecan) ameliorated the size and numbers of the tumors pronouncedly. Nogitecan (topotecan) is suggested to be an effective therapeutic agent for brain metastasis of small cell lung cancer after prophylactic cranial irradiation.
Dept. of Respiratory Medicine, Kyoto First Red Cross Hospital.
Ryoji
R
Yamada
Chieko
C
Takumi
Noriya
N
Hiraoka
Seiko
S
Ohno
Masahiko
M
Nakayama
Toshikazu
T
Yoshikawa
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000517:prevention & control / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000556:secondary*; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D019772:Topotecan / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D019772:Topotecan