[Effect of Cepharanthin in preventing radiation induced normal tissue damage in prostate cancer].
A total of 97 patients with prostate cancer who underwent radiotherapy were retrospectively reviewed to analyze the protective efficacy of Cepharanthin for acute or late toxicity to the bladder/urethra and rectum. Cepharanthin administrations were divided into 3 groups: intravenous, oral, and non-administration. Acute urinary toxicity was significantly milder for the intravenous group than for the oral and non-administration groups. The protective efficacy of Cepharanthin was not approved for acute rectal toxicity, but late rectal toxicity was significantly milder for the intravenous group than for the oral group. Intravenous Cepharanthin administration may prevent acute or late toxicity by radiotherapy for prostate cancer.
Dept of Radiology, University of Occupational and Environmental Health.
Satoshi
S
Nomoto
Hajime
H
Imada
Takayuki
T
Ohguri
Katsuya
K
Yahara
Fumio
F
Kato
Tomoaki
T
Morioka
Yukunori
Y
Korogi
D000368:Aged; D000470:Alkaloids / Q000627:therapeutic use*; D044182:Benzylisoquinolines; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012007:Rectum / Q000528:radiation effects; D012189:Retrospective Studies; D014521:Urethra / Q000528:radiation effects; D001743:Urinary Bladder / Q000528:radiation effects; D052117:Benzodioxoles
D000470:Alkaloids; D044182:Benzylisoquinolines; D011837:Radiation-Protective Agents; C006947:cepharanthine; D052117:Benzodioxoles