Diffuse optical tomography with physiological and spatial a priori constraints.
Diffuse optical tomography is a typical inverse problem plagued by ill-condition. To overcome this drawback, regularization or constraining techniques are incorporated in the inverse formulation. In this work, we investigate the enhancement in recovering functional parameters by using physiological and spatial a priori constraints. More accurate recovery of the two main functional parameters that are the blood volume and the relative saturation is demonstrated through simulations by using our method compared to actual techniques.
Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. xintes@art.ca
Xavier
X
Intes
Clemence
C
Maloux
Murat
M
Guven
Birzen
B
Yazici
Britton
B
Chance
D000465:Algorithms; D004058:Diffusion; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D013055:Spectrophotometry, Infrared / Q000295:instrumentation / Q000379:methods*; D013382:Subtraction Technique; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*