Hypolipidemic effects of modified psyllium preparations.
The hypolipidemic effects of two solid-state enzymatically modified psyllium preparations were compared to that of the original psyllium husks in hamsters. Hamsters were ad libitum fed 0.2 wt % cholesterol diets formulated to contain 12% cellulose or 5% cellulose plus 7% raw or enzymatically modified psyllium preparations. Psyllium additions to the diet did not significantly alter food consumption or the weekly mean hamster weight over the 5 weeks of feeding. However, the total weight gained over 35 days of feeding of modified psyllium Y-26-4, one of the modified psyllium preparations, was significantly lower, 48, 47, and 32% than that for the cellulose, raw psyllium, and modified psyllium Y-24-3 groups, respectively. At 35 days, psyllium feeding significantly reduced plasma total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol by 50-100% in comparison to cellulose feeding, with no significant differences between the psyllium preparations. Fecal dry weight was unaffected by dietary treatment. At days 29-31, fecal bile acid excretion was significantly increased by 30-70% with all three psyllium diets, with no significant differences between psyllium preparations. These results suggest that improving the functional properties of psyllium by solid-state enzymatic procedures, such that its incorporation into food products is feasible, does not alter psyllium-mediated hypolipidemic effects.
Allen
Kenneth G D
KG
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, Colorado 80523-1571, USA. allen@cahs.colostate.edu
Bristow
Sandee J
SJ
Yu
Liangli
L
D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D006224:Cricetinae; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D008647:Mesocricetus; D011620:Psyllium / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects
D001647:Bile Acids and Salts; D000960:Hypolipidemic Agents; D008055:Lipids; D011620:Psyllium