Mechanical evaluation of effect of grape seed proanthocyanidins extract on debilitated mandibles in rats.
Grape seed proanthocyanidins extract (GSPE), whose principal ingredient is proanthocyanidins, shows many activities such as cholesterol lowering effects, antioxidant effects, anti-tumor effects, cardioprotective effects, and protection against ultraviolet rays. However, reports of the effects of GSPE on bone are rare. We performed a mechanical analysis of the effect of GSPE on the interior structure of rat mandibular bone in the growth period, using three-dimensional peripheral quantitative computed tomography (pQCT). A low-calcium/high-calcium diet with supplementary GSPE was compared to a low-calcium/high-calcium diet in rats with debilitated mandibular bones. The group who received added GSPE showed a significant increase in cortical bone density, cross-sectional area, and trabecular bone mineral content (p<0.05). A significant increase was also seen in the results of a non-invasive stress strain index (SSI) (p<0.01) in the added GSPE. Our findings suggest that GSPE can increase bone quality and bone strength of rat mandibles in the growth period.
Department of Pediatric Dentistry, Kyushu Dental College, Manazuru, Kokurakita, Kitakyushu, Japan.
Masaru
M
Gunjima
Iwan
I
Tofani
Yukimi
Y
Kojima
Kenshi
K
Maki
Mitsutaka
M
Kimura
D016301:Alveolar Bone Loss / Q000188:drug therapy*; D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002136:Calcium, Dietary; D003799:Dental Stress Analysis; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D044945:Proanthocyanidins / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D014057:Tomography, X-Ray Computed / Q000379:methods; D027843:Vitis
D002136:Calcium, Dietary; D010936:Plant Extracts; D044945:Proanthocyanidins