Effects of cholinoblockers on acetylcholine content in rat striatum in neuroleptic-induced parkinsonism.
Correction of neuroleptic-induced parkinsonism in rats with two central cholinoblockers atropine and pentifine (acetylene aminoalcohol synthesized at Institute of Toxicology) were studied by measuring the content of acetylcholine in the striatum. The content of the transmitter secretion was estimated from the content of bound acetylcholine fraction in homogenates of the above-mentioned compartment of the brain. The results indicate that atropine and pentifine in doses equally effectively preventing catalepsy in rats had different effects on acetylcholine secretion in the striatum. Hence, cholinolytics with different pharmacological selective effects differently interact with central muscarine receptor subtypes.
Dagaev
S G
SG
Institute of Toxicology, Ministry of Health of Russian Federation, St. Petersburg, Russia. dsg@admiral.ru
Kosmachev
A B
AB
Soloveva
N E
NE
Filko
O A
OA
Sanotskii
V I
VI
Dolgo-Saburov
V B
VB
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity*; D001285:Atropine / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D051381:Rats; D011976:Receptors, Muscarinic / Q000145:classification / Q000187:drug effects / Q000378:metabolism
D014150:Antipsychotic Agents; D018680:Cholinergic Antagonists; D011976:Receptors, Muscarinic; D001285:Atropine; D000109:Acetylcholine