High-density lipoprotein subfractions and risk of coronary artery disease.
Numerous studies have shown that levels of high-density lipoprotein (HDL) cholesterol are inversely related to coronary artery disease risk. The HDL subfractions, however, seem to differ in their capacity to confer protection, with the large HDL2 subfraction appearing to be more important than the small HDL3 subfraction. Lipid-modifying drugs differ in their HDL-raising efficacy, and they also differ in how they affect HDL subfractions. Clinical trials show that raising total HDL cholesterol improves clinical and angiographic outcomes. It remains to be determined, however, whether a shift in distribution of HDL particles provides greater benefit than just an increase in total HDL.
Sidney Kimmel Laboratory for Preventive Cardiology, Thomas Jefferson University--Jefferson Heart Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA. john.morgan@jefferson.edu
John
J
Morgan
Christina
C
Carey
Anne
A
Lincoff
David
D
Capuzzi
D016632:Apolipoprotein A-I / Q000378:metabolism; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000150:complications / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000097:blood / Q000145:classification / Q000378:metabolism*; D017063:Outcome Assessment, Health Care; D012306:Risk
D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL