Human papillomavirus genotypes in cervical cancers in Mozambique.
The distribution of human papillomavirus (HPV) types in cervical cancers is essential for design and evaluation of HPV type-specific vaccines. To follow up on a previous report that HPV types 35 and 58 were the dominant HPV types in cervical neoplasia in Mozambique, the HPV types in a consecutive case series of 74 invasive cervical cancers in Mozambique were determined. The most common worldwide major oncogenic HPV types 16 and 18 were present in 69 % of cervical cancers, suggesting that a vaccine targeting HPV-16 and -18 would have a substantial impact on cervical cancer also in Mozambique.
Naucler
Pontus
P
Department of Medical Microbiology, University of Lund, S-20502 Malmö, Sweden.
da Costa
Flora Mabota
FM
Department of Gynaecology and Obstetrics, Central Hospital of Maputo, Mozambique.
Ljungberg
Otto
O
Department of Pathology, Malmö University Hospital, Sweden.
Bugalho
Antonio
A
Department of Gynaecology and Obstetrics, Central Hospital of Maputo, Mozambique.
Dillner
Joakim
J
Department of Medical Microbiology, University of Lund, S-20502 Malmö, Sweden.
D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000821:virology*