Successful retrograde transport of fluorescent latex nanospheres in the cerebral cortex of the macaque monkey.
Retrograde axonal transport of latex nanospheres offers a means of delivering chemical agents to a targeted region of the central nervous system (CNS). In this study we performed microinjections of latex nanospheres into the cerebral cortex of cynomolgus monkeys and observed successful retrograde labeling of neurons in the contralateral region. Our data indicate the successful use of this delivery system, reported in studies using other animals, may also be achievable with primates as well.
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa-shi, Chiba, Japan.
Yuki
Y
Sato
Daisuke
D
Koketsu
Naohide
N
Ageyama
Fumiko
F
Ono
Yusei
Y
Miyamoto
Tatsuhiro
T
Hisatsune
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D007840:Latex; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D008845:Microinjections; D043942:Nanotubes
D007840:Latex