In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat.
Cyclic fatty acid monomers (CFAM), which occur from the intramolecular cyclisation of linoleic and linolenic acids, are subsequently present in some edible oils and are suspected to induce metabolic disorders. One may suggest that the presence of a ring would alter the ability of the organism to oxidise these molecules. In order to test this hypothesis, we assessed the oxidative metabolism of CFAM in rats. For this purpose, rats were force-fed from 1.5 to 2.6 MBq of [1-(14)C]-linoleic acid, [1-(14)C]-linolenic acid, [1-(14)C]-CFAM-18:2 or [1-(14)C]-CFAM-18:3, and 14CO2 production was monitored for 24 h. The animals were then sacrificed and the radioactivity was determined in different tissues. No significant differences in 14CO2 production were found 24 h after the administration of CFAM and their respective precursors. Our data clearly demonstrate that, at least for the first beta-oxidation cycle, CFAM are oxidised in a similar way as both essential fatty acids.
Joffre
Florent
F
Institut National de la Recherche Agronomique, Unité de Nutrition Lipidique, Dijon, France.
Roy
Alexandre
A
Bretillon
Lionel
L
Pasquis
Bruno
B
Sergiel
Jean-Pierre
JP
Loreau
Olivier
O
Chardigny
Jean-Michel
JM
Sébédio
Jean-Louis
JL
D000284:Administration, Oral; D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis; D002250:Carbon Radioisotopes; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D019787:Linoleic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*
D002250:Carbon Radioisotopes; D005231:Fatty Acids, Unsaturated; D017962:alpha-Linolenic Acid; D002245:Carbon Dioxide; D019787:Linoleic Acid