[Relationship between the contents of serum HDL subclasses and the extent of coronary stenosis in coronary heart disease patients].
OBJECTIVE
To explore the relationship between the contents of serum HDL subclasses and the extent of coronary stenosis in coronary heart disease (CHD) patients.


METHODS
The contents of serum HDL subclasses in CHD patients (n = 51) and healthy controls (n = 56) were determined by two dimensional gel electrophoresis associated with immunodetection method. CHD patients were divided into three groups by average coronary severity score (CSS). Data were analyzed using linear regression and correlation method and multiple stepwise regression method.


RESULTS
It was found that as the extent of coronary stenosis increases, the levels of pre beta1-HDL, HDL3b increase, meanwhile the level of HDL2b decreases (P < 0.001). There were significant positive correlations between CSS and pre beta1-HDL (P < 0.01), HDL3a (P < 0.05), HDL3b (P < 0.01), and significant negative correlation was observed between CSS and HDL2b (P < 0.01). apoB100, HDL2b, TG, HDL-C, TC/HDL-C, apoAI are all independent risk factors of CHD.


CONCLUSIONS
The extent of coronary stenosis is highly correlated with the subclasses of HDL.
Biochemistry Research Laboratory, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Yong-xia
YX
Xu
Ming-de
MD
Fu
Yan-hua
YH
Xu
Lu-chuan
LC
Yang
D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000473:pathology; D016632:Apolipoprotein A-I / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000473:pathology; D023921:Coronary Stenosis / Q000097:blood / Q000473:pathology*; D005260:Female; D053442:High-Density Lipoproteins, Pre-beta; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000145:classification; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology
D016632:Apolipoprotein A-I; D053442:High-Density Lipoproteins, Pre-beta; D008075:Lipoproteins, HDL