Homoleptic ruthenium (II) complexes containing asymmetric tridentate 2-(benzimidazole-2-yl)-1,10-phenanthroline likes ligands: syntheses, characterization and DNA binding.
Two novel homoleptic ruthenium (II) complexes containing asymmetric tridentate ligands, 2-(benzimidazole-2-yl)-1,10-phenanthroline (PHBI) and 2-(naphtho[2,3-d]imidazole-2-yl)-1,10-phenanthroline (PHNI) have been synthesized and characterized by elemental analysis, mass spectra, (1)H NMR, and electronic spectroscopy. The DNA-binding properties of the complexes have been investigated by spectroscopic methods and viscosity measurements. The results indicate that the two complexes interact with DNA via electrostatic interaction, and the mechanisms of DNA binding with the complexes have also been discussed.
Institute of Chinese Materia Medica, School of Pharmacy, Guangxi Traditional Chinese Medical University 48, 179 Mingxiudong Road, Nanning Guangxi 530001, PR China. cwjiang@gxtcmu.edu.cn
Cai-Wu
CW
Jiang
D000818:Animals; D002417:Cattle; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D017975:Ruthenium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D014783:Viscosity
D007364:Intercalating Agents; D008024:Ligands; D010618:Phenanthrolines; D017975:Ruthenium Compounds; D003300:Copper; D004247:DNA; C025205:1,10-phenanthroline