Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula.
Two new cyclic peptides, cyclo-(glycyl-L-seryl-L-prolyl-L-glutamyl) and cyclo-(glycyl-L-prolyl-L-glutamyl), have been isolated from the cell extract of a Ruegeria strain associated with cell cultures of Suberites domuncula. Three other cyclopeptides have been isolated for the first time from a natural source. Additionally, a new diastereoisomer of a known compound is reported. The structures of isolated compounds have been elucidated by means of spectroscopic data (1D-, 2D-NMR, HRESIMS) and chiral HPLC analysis. The new cyclopeptides exhibited moderate antimicrobial activity against Bacillus subtilis.
Mitova
Maya
M
Istituto di Chimica Biomolecole CNR, via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy.
Popov
Simeon
S
De Rosa
Salvatore
S
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012623:Seawater; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D012336:RNA, Ribosomal, 16S; C489191:cyclo-(glycyl-L-prolyl-L-glutamyl); C489190:cyclo-(glycyl-L-seryl-L-prolyl-L-glutamyl)