Supplementation of fenugreek leaves lower lipid profile in streptozotocin-induced diabetic rats.
The present study was undertaken to evaluate the lipid-lowering effect of fenugreek leaves in diabetes mellitus. Albino Wistar rats were randomly divided into six groups: normal untreated rats; streptozotocin (STZ)-induced diabetic rats; STZ-induced rats + fenugreek leaves (0.5 g/kg of body weight); STZ-induced rats + fenugreek leaves (1 g/kg of body weight); STZ-induced rats + glibenclamide (600 microg/kg of body weight); and STZ-induced rats + insulin (6 units/kg of body weight). Rats were made diabetic by STZ (40 mg/kg) injected intraperitoneally. Fenugreek leaves were supplemented in the diet daily to diabetic rats for 45 days, and food intake was recorded daily. Blood glucose, total cholesterol, triglycerides, and free fatty acids were determined in serum, liver, heart, and kidney. Our results show that blood glucose and serum and tissue lipids were elevated in STZ-induced diabetic rats. Supplementation of fenugreek leaves lowered the lipid profile in STZ-induced diabetic rats.
Department of Biochemistry, Annamalai University, Annamalai Nagar-608 002, Tamil Nadu, India.
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Annida
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Stanely Mainzen Prince
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000032:analysis / Q000097:blood; D005260:Female; D005905:Glyburide / Q000008:administration & dosage; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D000960:Hypolipidemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D007668:Kidney / Q000737:chemistry; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000737:chemistry; D009206:Myocardium / Q000737:chemistry; D008517:Phytotherapy; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000032:analysis / Q000097:blood; D029910:Trigonella / Q000737:chemistry
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D005905:Glyburide