BCG (Bacille Calmette-Guérin) HspCs (heat-shock protein-peptide complexes) induce T-helper 1 responses and protect against live challenge in a murine aerosol challenge model of pulmonary tuberculosis.
The need for an effective TB (tuberculosis) vaccine remains acute, with tuberculosis still one of the major killers worldwide and 3 million new infections annually. We report here on the immune responses elicited by HspCs (heat-shock protein-peptide complexes) isolated from BCG (Bacille Calmette-Guérin) vaccine. These HspCs elicit both the appropriate cellular and protective immune responses required to merit their further development as TB vaccine candidates.
ImmunoBiology Limited, Babraham BioIncubator, Babraham, Cambridge CB2 4AT, UK. Camilo.Colaco@immunobiology.co.uk
C A L S
CA
Colaco
C R
CR
Bailey
J
J
Keeble
K B
KB
Walker
D000336:Aerosols; D000818:Animals; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000378:metabolism*
D000336:Aerosols; D006360:Heat-Shock Proteins