Minimal change nephrotic syndrome after allogenic hematopoietic stem cell transplantation.
We describe a 24-year-old man who developed minimal change nephrotic syndrome after allogenic hematopoietic stem cell transplantation (HSCT). One year after undergoing allogenic peripheral blood stem cell transplantation (PBSCT), this patient presented with proteinuria. He also presented with skin and lip lesions considered to be chronic graft-versus host disease. Observation of renal biopsy specimens by light microscopy revealed minor glomerular abnormalities. However, electron microscopy disclosed focal mesangial interposition, irregular thickening of the glomerular basement membrane and subendothelial loosening. Two years after HSCT, the patient developed nephrotic syndrome. Long use of cyclosporine improved the proteinuria and hypoalbuminemia within 12 months.
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Miyazaki.
Yuji
Y
Sato
Seiichiro
S
Hara
Shouichi
S
Fujimoto
Kazuhiro
K
Yamada
Hisashi
H
Sakamaki
Tanenao
T
Eto
D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009402:Nephrosis, Lipoid / Q000188:drug therapy / Q000209:etiology*; D014184:Transplantation, Homologous / Q000009:adverse effects; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine