Role of flagellum and motility in pathogenesis of Vibrio vulnificus.
To assess the role of the flagellum which was detected by immunoscreening of surface proteins of Vibrio vulnificus, an flgE-deleted mutant was constructed and tested for its pathogenicity. The ability of this nonmotile mutant to adhere to INT-407 cells and its role in biofilm were decreased, as was its lethality to mice.
Department of Parasitology and Institute of Tropical Medicine, BK21 Project for Medical Science, Yonsei University, Seoul 120-752, Korea.
Jong-Ho
JH
Lee
Jong Bok
JB
Rho
Kyung-Je
KJ
Park
Chang Beom
CB
Kim
Yang-Soo
YS
Han
Sang Ho
SH
Choi
Kyu-Ho
KH
Lee
Soon-Jung
SJ
Park
D000818:Animals; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development; D002460:Cell Line; D005260:Female; D005407:Flagella / Q000502:physiology*; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D009068:Movement; D009154:Mutation; D014735:Vibrio Infections / Q000382:microbiology / Q000401:mortality; D041261:Vibrio vulnificus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology
D001426:Bacterial Proteins; C097681:FlgE protein, Bacteria