Granular cell tumor of colon: report of a case and review of literature.
Granular cell tumor (GCT) is uncommon in the colon and rectum. Here we report a case of GCT in the transverse colon. A 48-year-old male patient underwent a screening colonoscopy. A yellowish sessile lesion, about 4 mm in diameter, was found in the transverse colon. An endoscopic snare resection was performed without complication. Histological examination revealed the tumor consisted of plump neoplastic cells with abundant granular eosinophilic cytoplasm containing acidophilic periodic acid Schiff-positive, diastase-resistant granules. Immunohistochemical analysis showed the tumor cells expressed S-100 protein and neuron-specific enolase. Thus, the resected tumor was diagnosed as a GCT. Since GCTs are usually benign, endoscopic resection constitutes an easy and safe treatment. Colonoscopists should consider the possibility of GCT in the differential diagnosis of submucosal tumors of the colon.
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang, Gyeonggi 411-769, Korea.
Dae-Kyung
DK
Sohn
Hyo-Seong
HS
Choi
Yeon-Soo
YS
Chang
Jin-Myeong
JM
Huh
Dae-Hyun
DH
Kim
Dae-Yong
DY
Kim
Young-Hoon
YH
Kim
Hee-Jin
HJ
Chang
Kyung-Hae
KH
Jung
Seung-Yong
SY
Jeong
D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged