Genetic influences in the aetiology of tears of the rotator cuff. Sibling risk of a full-thickness tear.
From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.
Harvie
P
P
Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Headington, England.
Ostlere
S J
SJ
Teh
J
J
McNally
E G
EG
Clipsham
K
K
Burston
B J
BJ
Pollard
T C B
TC
Carr
A J
AJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D000070636:Rotator Cuff Injuries; D012421:Rupture / Q000235:genetics; D035781:Siblings