Geminin: a major DNA replication safeguard in higher eukaryotes.
Eukaryotes have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. These mechanisms prevent relicensing of origins of replication after initiation of DNA replication in S phase until the end of mitosis. Most of our knowledge of mechanisms controlling prereplication complex (preRC) formation are based on studies from yeast and Xenopus, while much less is known for mammalian cells. Here we discuss our recent data demonstrating that Geminin is required for preventing rereplication in human normal and cancer cells.
European Institute of Oncology, Department of Experimental Oncology, Milan, Italy.
Marina
M
Melixetian
Kristian
K
Helin
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D005057:Eukaryotic Cells / Q000737:chemistry / Q000378:metabolism; D064248:Geminin; D006801:Humans; D029867:Xenopus Proteins
D018797:Cell Cycle Proteins; C577998:GMNN protein, Xenopus; C577995:GMNN protein, human; D064248:Geminin; D029867:Xenopus Proteins