Experimental study of the rat for the assessment of barium coating on the gastric mucosa: efficacy of ranitidine and acetylcysteine administration.
OBJECTIVE
In order to improve the preparation method for barium examination of the stomach by ranitidine and acetylcysteine use, the effect on the rat gastric mucosa caused by the administration of ranitidine and acetylcysteine was studied.


METHODS
Rat stomach that had been treated with ranitidine or acetylcysteine at different intervals and examined in vivo was excised and coated with a barium suspension. A radiograph was subsequently taken and evaluated in regard to the removal of gastric mucus and imaging of the areae gastricae (AG). The removal of mucus was assessed by six blind observers. The imaging of AG was estimated as a percentage of the imaged AG area per total gastric corpus.


RESULTS
No change was seen on the radiograph with ranitidine preparation, while the mucus was distinctly removed and AG well-imaged in the group studied 15 minutes after the peroral administration of acetylcysteine.


CONCLUSIONS
Proper preparation for barium study of the stomach should involve treatment with a mucolytic agent about 15 minutes before the examination. H2-blockers must be used supplementally in the short term.
Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Yoshinori
Y
Sugino
Wolfhard
W
Semmler
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D001466:Barium Sulfate; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000000981:diagnostic imaging / Q000187:drug effects*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D011859:Radiography; D011899:Ranitidine / Q000494:pharmacology*; D051381:Rats; D013272:Stomach Diseases / Q000175:diagnosis
D016166:Free Radical Scavengers; D006635:Histamine H2 Antagonists; D001466:Barium Sulfate; D011899:Ranitidine; D000111:Acetylcysteine