Cerebellar paraganglioma.
Paragangliomas arising as primary neoplasms in the intracranial portion of the central nervous system are relatively uncommon and only have been rarely reported. We report a case of apparent primary paraganglioma arising in the left cerebellar hemisphere in an 11-year-old girl who presented with a 6-month history of headaches. The tumor was marked by a nested architectural pattern (zellballen), delimited by S-100-positive sustentacular cells. Morphologic and immunohistochemical features of the neoplasm are discussed and literature is reviewed regarding involvement of the central nervous system by paraganglioma.
Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA.
Richard A
RA
Prayson
Ali
A
Chahlavi
Mark
M
Luciano
D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D010235:Paraganglioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery