Executive functions following traumatic brain injury in young children: a preliminary analysis.
To examine executive processes in young children with traumatic brain injury (TBI), we evaluated performance of 44 children who sustained moderate-to-severe TBI prior to age 6 and to 39 comparison children on delayed response (DR), stationary boxes, and spatial reversal (SR) tasks. The tasks have different requirements for holding mental representations in working memory (WM) over a delay, inhibiting prepotent responses, and shifting response set. Age at the time of testing was divided into 10- to 35- and 36- to 85-month ranges. In relation to the community comparison group, children with moderate-to-severe TBI scored significantly lower on indexes of WM/inhibitory control (IC) on DR and stationary boxes tasks. On the latter task, the Age x Group interaction indicated that performance efficiency was significantly reduced in the older children with TBI relative to the older comparison group; performance was similar in younger children irrespective of injury status. The TBI and comparison groups did not differ on the SR task, suggesting that shifting response set was not significantly altered by TBI. In both the TBI and comparison groups, performance improved with age on the DR and stationary boxes tasks. Age at testing was not significantly related to scores on the SR task. The rate of acquisition of working memory (WM) and IC increases steeply during preschool years, but the abilities involved in shifting response set show less increase across age groups (Espy, Kaufmann, & Glisky, 2001; Luciana & Nelson, 1998). The findings of our study are consistent with the rapid development hypothesis, which predicts that skills in a rapid stage of development will be vulnerable to disruption by brain injury.
Ewing-Cobbs
Linda
L
Department of Pediatrics, University of Texas Health Science Center, 7000 Fannin, Suite 2401, Houston, TX 77030, USA. linda.ewing-cobbs@uth.tmc.edu
Prasad
Mary R
MR
Landry
Susan H
SH
Kramer
Larry
L
DeLeon
Rosario
R
D001288:Attention / Q000502:physiology*; D020208:Brain Injury, Chronic / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007266:Inhibition, Psychological; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D009949:Orientation / Q000502:physiology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D011340:Problem Solving / Q000502:physiology*; D011594:Psychometrics; D012718:Set, Psychology