Elimination of linezolid by an in vitro extracorporeal circuit model.
Linezolid is an oxazolidinone antibiotic with activity against important grampositive aerobic bacteria, including nosocomial pathogens. It is not known whether dosage adjustments are necessary in patients treated with continuous renal replacement therapies. This in vitro study was conducted to investigate the elimination of linezolid in an in vitro continuous hemo(dia)filtration model using different filter materials (polysulfone, polyacrylonitrile, polyamide), surface areas, and different modes of renal replacement therapies. Linezolid was measured using HPLC with UV-detection. No adsorption of linezolid to any of the tested membranes was detected. Recovery of linezolid in the ultrafiltrate was 98.2 +/- 10.5% in the filtration mode. During dialysis, recovery was significantly less (87.6 +/- 16.1%; p = 0.02). Linezolid elimination was not altered by filter size, when polysulfone filters with surface areas of 0.7 m2 and 1.3 m2 were tested. In conclusion, the dosage recommendations for linezolid are independent of the filter materials. However, the elimination is significantly higher during hemofiltration compared to dialysis.
Department of Anesthesiology and Intensive Care Medicine, Tuebingen University Hospital, Tuebingen, Germany. torsten.schroeder@uni-tuebingen.de
T H
TH
Schroeder
M
M
Hansen
M
M
Stephan
E
E
Hoffmann
K
K
Unertl
W A
WA
Krueger
D000081:Acetamides / Q000493:pharmacokinetics*; D000180:Acrylic Resins; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001672:Biocompatible Materials; D005112:Extracorporeal Circulation; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D000069349:Linezolid; D008567:Membranes, Artificial; D008954:Models, Biological; D009757:Nylons; D023303:Oxazolidinones / Q000493:pharmacokinetics*; D011108:Polymers; D051437:Renal Insufficiency / Q000628:therapy; D013450:Sulfones; D013499:Surface Properties
D000081:Acetamides; D000180:Acrylic Resins; D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D009757:Nylons; D023303:Oxazolidinones; D011108:Polymers; D013450:Sulfones; C010504:polyacrylonitrile; C017662:polysulfone P 1700; D000069349:Linezolid