A novel platinum reagent [chloro(2,2':6',2"-terpyridine)platinum(II) chloride] for use in heavy-atom derivatization of protein crystals.
A platinum chromophore, chloro(2,2':6',2"-terpyridine)platinum(II) chloride, previously used in labelling active-site histidines of serine proteases, proves to be a useful reagent in heavy-atom derivatization of protein crystals for X-ray crystallographic phase determination.
Department of Chemistry, University of York, Heslington, England.
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Lawson