Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy.
The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.
Cerminara
Caterina
C
Department of Developmental Neurology and Psychiatry, Division of Neurosciences, Tor Vergata University, Rome, Italy.
Montanaro
Maria Lucia
ML
Curatolo
Paolo
P
Seri
Stefano
S
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography; D019305:Epilepsy, Rolandic / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D009207:Myoclonus / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced*; D020919:Sleep Disorders, Intrinsic / Q000188:drug therapy / Q000503:physiopathology; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine