Inflammation and autoimmunity as a central theme in neurodegenerative disorders: fact or fiction?
Irrespective of the initiating stimuli, neurodegenerative disorders including multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease and stroke share many characteristics of inflammation and autoimmunity. This review summarizes and correlates the information relating to the role of cytokines and chemokines in initiating and propagating the inflammatory/immune response in these pathologies. For example, in MS there is a continuous realignment in the inflammatory and immune response. However, due to the redundancy in the cytokine/chemokine response, it is extremely unlikely that any one therapy will be successful in treating neurodegenerative diseases. This review attempts to highlight specific targets for therapeutic intervention.
Clarkson
Andrew N
AN
University of Otago, Department of Pharmacology and Toxicology, Dunedin, New Zealand.
Rahman
Rosanna
R
Appleton
Ian
I
D015551:Autoimmunity / Q000276:immunology*; D001921:Brain / Q000276:immunology; D018925:Chemokines / Q000145:classification / Q000276:immunology; D016207:Cytokines / Q000145:classification / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D019636:Neurodegenerative Diseases / Q000276:immunology*
D018925:Chemokines; D016207:Cytokines