Transient spleen enlargement in peripheral blood progenitor cell donors given G-CSF.
The administration of granulocyte colony-stimulating factor (G-CSF) to peripheral blood progenitor cell (PBPC) donors causes spleen length to increase, but the duration of enlargement is not known. Eighteen healthy subjects were given 10 microg/kg of G-CSF for 5 days and a PBSC concentrate was collected by apheresis. Ultrasound scans were used to assess craniocaudal spleen length before and after G-CSF administration. Mean spleen length increased from a baseline length of 10.7 +/- 1.3 cm to 12.1 +/- 1.2 cm on the apheresis day (p < 0.001). Ten days after apheresis, spleen length fell to 10.5 +/- 1.2 cm and did not differ from baseline levels (p = 0.57), but in 3 subjects remained 0.5 cm greater than baseline length. Increases in spleen length in PBPC donors are transient and reversible.
Department of Transfusion Medicine, Warren G, Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. dstroncek@cc.nih.gov
David F
DF
Stroncek
Kristin
K
Dittmar
Thomas
T
Shawker
Angela
A
Heatherman
Susan F
SF
Leitman