[An attempt for standardization of serum CA19-9 levels, in order to dissolve the gap between three different methods].
It is well known that serious method-related differences exist in results of serum CA19-9, and the necessity of standardization has been pointed out. In this study, differences of serum tumor marker CA19-9 levels obtained by various immunoassay kits (CLEIA, FEIA, LPIA and RIA) were evaluated in sixty-seven clinical samples and five calibrators and the possibility to improve the inter-methodological differences were observed not only for clinical samples but also for calibrators. We supposed an assumed standard material using by a calibrator. We calculated the serum levels of CA19-9 when using the assumed standard material for three different measurement methods. We approximate the CA19-9 values using by this method. It is suggested that the obtained CA19-9 values could be approximated by recalculation with the assumed standard material would be able to correct between-method and between-laboratory discrepancies in particular systematic errors.
Hayashi
Kuniki
K
The Department of Laboratory Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo 173-8610.
Hoshino
Tadashi
T
Yanai
Mitsuru
M
Tsuchiya
Tatsuyuki
T
Kumasaka
Kazunari
K
Kawano
Kinya
K
D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D002138:Calibration; D006801:Humans; D011863:Radioimmunoassay; D011933:Reagent Kits, Diagnostic / Q000592:standards*; D012016:Reference Values
D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D011933:Reagent Kits, Diagnostic