Long-term acquisition of allergen-specific IgE and asthma following allogeneic bone marrow transplantation from allergic donors.
Adoptive transfer of allergen-specific immunoglobulin E (IgE) from atopic donors to nonatopic recipients occurs during the first year following bone marrow transplantation (BMT). Mature B- and T-cell clones with allergen-specific memory and hematopoietic progenitor cells are transferred through BMT. The objective of this study was to characterize the long-term rate of allergic sensitization and development of clinical allergic diseases following BMT from atopic donors. A long-term follow-up study was conducted in a cohort of donor and recipient pairs with moderate-to-severe allergic disease in the donor prior to BMT. Assessments of allergen-specific IgE, clinical rhinitis, and asthma were made in the donors prior to BMT and in the recipients with a mean follow-up of 15.5 years after BMT. From an initial cohort of 12 bone marrow transplant recipients who received marrow from allergic donors, 5 long-term survivors were identified. Allergen-specific IgE transferred from donor to recipient following BMT frequently persisted, and a high rate of de novo allergic sensitization was observed between 1 and 14 years after BMT. These events were associated with elevation in total IgE, and development of allergic rhinitis and asthma at long-term follow-up. We conclude that marrow-derived immune cells from allergic donors can transfer the predisposition to allergy and asthma.
Hallstrand
Teal S
TS
Department of Medicine, University of Washington, BB-1333 Health Sciences, Box 356523, 1959 NE Pacific St, Seattle, WA 98195-6523, USA.
Sprenger
Jay D
JD
Agosti
Jan M
JM
Longton
Gary M
GM
Witherspoon
Robert P
RP
Henderson
William R
WR
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D039981:Pyroglyphidae / Q000276:immunology; D012220:Rhinitis / Q000276:immunology; D014019:Tissue Donors; D014184:Transplantation, Homologous
D007073:Immunoglobulin E