Developmental biology: Notching the hindbrain.
One of the best-characterized lineage restrictions in developing vertebrates occurs between adjacent -rhombomeres of the hindbrain. It was recently shown that cells at the boundaries of zebrafish rhombomeres also differ from non-boundary cells in their migratory abilities, a difference driven by Notch signaling.
Blair
Seth S
SS
Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, Wisconsin 53706, USA. ssblair@wisc.edu
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000235:genetics / Q000502:physiology; D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D017351:N-Acetylglucosaminyltransferases / Q000378:metabolism; D051880:Receptors, Notch; D012249:Rhombencephalon / Q000196:embryology*; D015398:Signal Transduction / Q000502:physiology*; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics
D029721:Drosophila Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; D017351:N-Acetylglucosaminyltransferases; C090576:fng protein, Drosophila