Chewing the fat; regulating autophagy in Drosophila.
Autophagy is the major cellular process responsible for bulk cytoplasmic degradation. Two reports in this issue of Developmental Cell describe how both PI3 kinase and TOR signaling in Drosophila are critical for controlling autophagy in response to developmental and environmental cues.
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 USA.
Savraj S
SS
Grewal
Leslie J
LJ
Saucedo
D000818:Animals; D001343:Autophagy; D017173:Caenorhabditis elegans; D003593:Cytoplasm / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D007328:Insulin / Q000378:metabolism; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011494:Protein Kinases; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases; D013997:Time Factors
D029721:Drosophila Proteins; D007328:Insulin; D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D058570:TOR Serine-Threonine Kinases; C416303:target of rapamycin protein, Drosophila