Safety for preoperative use of steroids for transsternal thymectomy in myasthenia gravis.
OBJECTIVE
Effects of preoperative steroids on morbidity and mortality after transsternal thymectomy are analyzed.


METHODS
There were 620 transsternal thymectomies for myasthenia gravis performed in the period 1973-2002. There were 547 patients with nonthymomatous myasthenia, including 17 patients submitted to repeated thymectomy (rethymectomy) and 46 patients with thymoma. There were 522 upper median sternotomies performed in the period 1973-1997 and 98 complete median sternotomies performed in the period 1998-2002 (74 patients without thymoma, 7 thymomas and 17 rethymectomies). One hundred and seventeen of these 620 patients were taking steroids preoperatively. The impact of steroids use on postoperative respiratory insufficiency (ventilator), need for tracheostomy, superficial wound dehiscence, superficial wound suppuration, sternal dehiscence and mortality was analyzed.


RESULTS
The rate of morbidity and mortality in the steroids and the no-steroids groups included respiratory insufficiency necessitating the use of a ventilator in 46/503 patients from the no-steroids group (9.1%) and 8/117 patients from the steroids group (6.8%; P = 0.4260), need for tracheostomy in 14/503 patients from the no-steroids group (2.8%) and 3/117 patients from the steroids group (2.6%; P = 9054). Complications with wound healing (including sternal dehiscence, superficial wound dehiscence and superficial wound suppuration) occurred in 47/503 (9.3%) patients from the no-steroids group and in 1/117 (0.9%) patient from the steroids group (P = 0.0023) The overall complications rate was 30.6% (154/503) in the no-steroids group and 11.1% (13/117) in the steroids group (P = 0.0001). Mortality rate in the no-steroids group was 0.4% (2/503 patients) and none in the steroids group. Morbidity in patients with complete sternotomy was low, respiratory insufficiency in three patients (3.1%), and superficial wound suppuration in one patient (1.0%), no other morbidity and no mortality. Changing morbidity in periods 1973-1980, 1981-1990 and 1991-2002 is analyzed.


CONCLUSIONS
Preoperative use of steroids for transsternal thymectomy in patients with myasthenia gravis had no negative impact on morbidity and mortality, conversely, the results in patients taking steroids were better, with significant difference of results regarding the overall complication rates and the overall complication rates of wound healing.
Department of Thoracic Surgery, Pulmonary Hospital, Zakopane, ul. Gładkie 1, 34-500 Zakopane, Poland. marcinz@mp.pl
Marcin
M
Zieliński
Jarosław
J
Kuzdzał
Bartłomiej
B
Staniec
Maria
M
Harazda
Tomasz
T
Nabiałek
Juliusz
J
Pankowski
Artur
A
Szlubowski
Jerzy
J
Medoń
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009017:Morbidity; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000401:mortality; D011241:Prednisone / Q000009:adverse effects; D011300:Preoperative Care / Q000009:adverse effects / Q000379:methods*; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012189:Retrospective Studies; D013249:Sternum / Q000601:surgery; D013256:Steroids / Q000009:adverse effects*; D013529:Surgical Wound Dehiscence / Q000139:chemically induced; D013934:Thymectomy / Q000379:methods*; D013945:Thymoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D013953:Thymus Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D014139:Tracheostomy
D013256:Steroids; D011241:Prednisone