Adverse drug reactions in the orofacial region.
A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.
Scully
C
C
Eastman Dental Institute for Oral Health Care Sciences, University College, University of London, 256 Gray's Inn Road, London WC1X 8LD, UK. scully.c@eastman.ucl.ac.uk
Bagan
J-V
JV
D064420:Drug-Related Side Effects and Adverse Reactions; D005157:Facial Pain / Q000139:chemically induced; D005881:Gingiva / Q000187:drug effects*; D006801:Humans; D009059:Mouth Diseases / Q000139:chemically induced*; D009061:Mouth Mucosa / Q000187:drug effects*; D013651:Taste Disorders / Q000139:chemically induced; D014075:Tooth Discoloration / Q000139:chemically induced; D020433:Trigeminal Nerve Diseases / Q000139:chemically induced