In vitro killing of Mycobacterium ulcerans by acidified nitrite.
Mycobacterium ulcerans, which causes Buruli ulcer, was exposed to acidified nitrite or to acid alone for 10 or 20 min. Killing was rapid, and viable counts were reduced below detectable limits within 10 min of exposure to 40 mM acidified nitrite. M. ulcerans is highly susceptible to acidified nitrite in vitro.
Phillips
R
R
Komfo Anokye Teaching Hospital, Kumasi, Ghana. rphillip@sghms.ac.uk
Kuijper
S
S
Benjamin
N
N
Wansbrough-Jones
M
M
Wilks
M
M
Kolk
A H J
AH
D000143:Acids / Q000494:pharmacology; D015169:Colony Count, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009164:Mycobacterium Infections / Q000382:microbiology; D019911:Mycobacterium ulcerans / Q000187:drug effects*; D009573:Nitrites / Q000494:pharmacology*; D009589:Nitrogen Oxides / Q000494:pharmacology
D000143:Acids; D009573:Nitrites; D009589:Nitrogen Oxides