GIFT domains: linking eukaryotic intraflagellar transport and glycosylation to bacterial gliding.
We describe GIFT [for GldG, intraflagellar transport (IFT)] domains in the flavobacterial gliding protein GldG and eukaryotic IFT-52. In eukaryotes, domain homologues are also found in the eukaryotic oligosaccharyltransferase complex and in subtilisin kexin isozyme-1 (SKI-1 or S1P). A distant evolutionary relationship to periplasmic-binding proteins hints that GIFT domains might possess oligosaccharide-binding functions.
Microbial Genomics Group, Institute for Biomedical Research, Division of Immunity and Infection, Medical School, University of Birmingham, Birmingham, UK B15 2TT.
Scott
S
Beatson
Chris P
CP
Ponting
D020418:Algal Proteins / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D005075:Biological Evolution; D005057:Eukaryotic Cells / Q000502:physiology*; D005407:Flagella / Q000737:chemistry* / Q000502:physiology*; D005417:Flavobacterium / Q000502:physiology; D006031:Glycosylation; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000378:metabolism; D043484:Proprotein Convertases / Q000502:physiology; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D015800:Protozoan Proteins / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D017386:Sequence Homology, Amino Acid
D020418:Algal Proteins; D001426:Bacterial Proteins; D009844:Oligosaccharides; D015800:Protozoan Proteins; D029701:Saccharomyces cerevisiae Proteins; D043484:Proprotein Convertases; C058751:KEX2 protein, S cerevisiae