Characterization of adenylate cyclase-hemolysin gene duplication in a Bordetella pertussis isolate.
We describe a clinical isolate of Bordetella pertussis, the agent responsible for whooping cough, composed of at least two clones harboring one or two copies of the cya locus encoding one of the major toxins, adenylate cyclase-hemolysin. No difference was observed between the two clones in murine and cellular models, probably due to the high instability of the cya locus duplication.
Dalet
Karine
K
Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
Weber
Christian
C
Guillemot
Laurent
L
Njamkepo
Elisabeth
E
Guiso
Nicole
N
D037361:Adenylate Cyclase Toxin / Q000235:genetics* / Q000633:toxicity*; D000818:Animals; D001886:Bordetella pertussis / Q000235:genetics / Q000472:pathogenicity*; D002460:Cell Line; D004195:Disease Models, Animal; D020440:Gene Duplication; D006801:Humans; D008264:Macrophages; D051379:Mice; D014132:Trachea / Q000382:microbiology; D014917:Whooping Cough / Q000382:microbiology*
D037361:Adenylate Cyclase Toxin