Cytotoxic furanosesterterpenes from a marine sponge Psammocinia sp.
Three new (1-3) and seven known (4-10) cytotoxic furanosesterterpenes were isolated from a marine sponge Psammocinia sp. by bioactivity-guided fractionation. The structures were established on the basis of NMR and MS analyses. The geometry and absolute configuration were determined on the basis of optical rotation, NMR, and CD data. These compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines, and most of the compounds showed toxicity to SK-MEL-2. The mixture of compounds 7 and 8 displayed significant inhibition of DNA replication and moderate antioxidant profile.
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Kyutaek
K
Choi
Jongki
J
Hong
Chong-O
CO
Lee
Dong-Kyoo
DK
Kim
Chung Ja
CJ
Sim
Kwang Sik
KS
Im
Jee H
JH
Jung
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004261:DNA Replication / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005663:Furans; D054830:Sesterterpenes; D013729:Terpenes; C489195:psammocinin A1; C489196:psammocinin A2; C489201:psammocinin B