Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin.
Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) influencing whole blood serotonin in 567 members of a single large pedigree, using a novel association-based mapping approach. We identified an association between the beta3 integrin (ITGB3) Leu33Pro polymorphism on 17q21 and whole blood serotonin levels (P-value = 9.8 x 10(-5)). This variant explained the evidence for linkage in this region when included as a covariate in the linkage analysis (change in LOD from 1.87 to 0.16), indicating that ITGB3 may be an important serotonin QTL.
Weiss
Lauren A
LA
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Veenstra-Vanderweele
Jeremy
J
Newman
Dina L
DL
Kim
Soo-Jeong
SJ
Dytch
Harvey
H
McPeek
Mary Sara
MS
Cheng
Suzanne
S
Ober
Carole
C
Cook
Edwin H
EH
Abney
Mark
M
D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D040641:Quantitative Trait Loci; D012701:Serotonin / Q000097:blood*
C061248:ITGB3 protein, human; D039661:Integrin beta3; D012701:Serotonin