Clinical value of the ultrasound Doppler index in determination of ovarian tumor malignancy.
OBJECTIVE
Clinical evaluation of the newly created Doppler index (DS) in preoperative early differentiation of ovarian tumor malignancy.


METHODS
The study involved data concerning 464 ovarian tumor examinations of women treated between 1994 and 2002. One hundred and sixty-five woman had malignant ovarian tumors, and the other 299 tumors were benign on histopathology. Menopausal status of the studied women was also considered. Created ROC curves compare the diagnostic value of the suggested index. The number of vessels, their location and arrangement, shape of velocity waves as well as presence of the protodiastolic notch in the arterial vessels of the tumor were analyzed. Each of the mentioned features could acquire a point-value of 0 or 1.


RESULTS
A cut-off point for the suggested Doppler index was determined at the level of 4 for the following prognostic values: sensitivity, specificity and accuracy which amounted to 86.7%; 93.3% and 90.9%, respectively. In the group of 101 postmenopausal women accuracy was higher--94.1%, specificity and positive predictive value (PPV) was estimated as 100%.


CONCLUSIONS
The suggested Doppler index enables a precise prognosis of ovarian tumor malignancy and as a half-amount analysis helps in the decision making of the most effective therapeutic treatment.
Division of Gynecological Surgery, Department of Gynecology and Obstetrics, Karol Marcinkowski University of Medical Sciences, Poznan, Poland.
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D
Szpurek
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Moszyńiki
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Sajdak
D000328:Adult; D000367:Age Factors; D000368:Aged; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010049:Ovarian Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy / Q000379:methods; D017698:Postmenopause; D011237:Predictive Value of Tests; D017697:Premenopause; D011300:Preoperative Care; D011336:Probability; D011379:Prognosis; D012372:ROC Curve; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018615:Ultrasonography, Doppler, Color / Q000379:methods*