Beta-lactam antibiotic-induced pseudoporphyria.
A case of beta-lactam antibiotic-induced pseudoporphyria is presented. A 24-year-old African American woman with systemic lupus erythematosus and end-stage renal disease on hemodialysis developed tense bullae on her forehead and cheeks after exposure to ampicillin-sulbactam and cefepime. Histologically, the lesions were similar to porphyria cutanea tarda, but without the associated porphyrin abnormalities. The lesions resolved spontaneously on cessation of the antibiotics.
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. tphung@bidmc.harvard.edu
Thuy L
TL
Phung
Clare A
CA
Pipkin
Steven R
SR
Tahan
Diane S
DS
Chiu
D018784:Abdominal Abscess / Q000150:complications / Q000188:drug therapy; D000667:Ampicillin / Q000009:adverse effects*; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D001706:Biopsy; D005184:Fallopian Tube Diseases / Q000150:complications / Q000188:drug therapy; D005260:Female; D005546:Forehead; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008875:Middle Aged; D010049:Ovarian Diseases / Q000150:complications / Q000188:drug therapy; D011537:Pruritus / Q000139:chemically induced; D006435:Renal Dialysis; D012805:Sickle Cell Trait / Q000150:complications; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D013407:Sulbactam / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000150:complications
D000900:Anti-Bacterial Agents; C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam