A lipid-peptide microbicide inactivates herpes simplex virus.
A microbicide combining the lipid-ether 1-0-octyl-sn-glycerol (OG; 3 mM) and peptide D2A21 (9 microM) reduced herpes simplex virus type 1 (HSV-1) and HSV-2 titers by at least 1,000-fold, more than the sum of the inactivations produced by OG and D2A21 alone. OG plus D2A21 reduced HSV-1 and HSV-2 titers by > or =1,000-fold in < or =10 and < or =20 min, respectively, whereas OG and D2A21 used alone produced almost no virus inactivation during these times.
Isaacs
Charles E
CE
New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Biochemistry, Staten Island, New York 10314, USA. chisi@cunyvm.cuny.edu
Jia
Jun Hua
JH
Xu
Weimin
W
D023181:Antimicrobial Cationic Peptides; D000998:Antiviral Agents / Q000494:pharmacology*; D004338:Drug Combinations; D005995:Glyceryl Ethers / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D010455:Peptides / Q000494:pharmacology*
C490932:1-O-octyl-sn-glycerol; D023181:Antimicrobial Cationic Peptides; D000998:Antiviral Agents; C430264:D2A21; D004338:Drug Combinations; D005995:Glyceryl Ethers; D010455:Peptides