High-throughput characterization and quality control of small-molecule combinatorial libraries.
To fully realize the potential of combinatorial synthesis and high-throughput screening for increasing the efficiency of the drug discovery and development process, issues related to compound purity must be addressed. Impurities, often present after synthesis, can lead to ambiguous screening results and inhibit the development of quality structure-activity relationships. The demand for high-throughput analytical characterization of combinatorial libraries has prompted the development of more rapid methods to keep pace with compound production. Recent progress has focused upon the development of parallel separation methods, multiplexed detector interfaces, and synergistic combinations of different detectors possessing complementary selectivities.
CombiSep, Inc, 2711 South Loop Drive, Ames, Iowa 50010, USA. jeremy.kenseth@combisep.com
Jeremy R
JR
Kenseth
Shelley J
SJ
Coldiron
D020650:Combinatorial Chemistry Techniques / Q000379:methods / Q000592:standards*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000592:standards*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008970:Molecular Weight; D011786:Quality Control; D013329:Structure-Activity Relationship; D013997:Time Factors