What can one learn from experiments about the elusive transition state?
We present the results of an exact analysis of a model energy landscape of a protein to clarify the idea of the transition state and the physical meaning of the phi values determined in protein engineering experiments. We benchmark our findings to various theoretical approaches proposed in the literature for the identification and characterization of the transition state.
Department of Physics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Iksoo
I
Chang
Marek
M
Cieplak
Jayanth R
JR
Banavar
Amos
A
Maritan
D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011336:Probability; D011487:Protein Conformation; D015202:Protein Engineering / Q000379:methods; D017510:Protein Folding; D017433:Protein Structure, Secondary
D010455:Peptides