Effect of nifedipine and amlodipine on wound healing in rats.
The wound healing effect of two calcium channel blockers, nifedipine and amlodipine was studied in rats using incision and excision wound models. In incision wound, two straight paravertebral skin thickness incision were made and on tenth day skin tensile strength was measured by using continuous water flow technique. In excision wound, circular piece of skin excised in its full thickness and wound contraction monitored by alternate day wound tracing and epithelisation period was monitored by noting the number of days required for escher to fall. Drugs enhanced the skin tensile strength in incision wound model. In excision wound model, wound contraction is increased on 4th and 16th day but epithlisation period was not significantly altered. In conclusion, calcium channel blockers can be used to enhance wound healing, especially if wound healing was suppressed by steroids.
Department of Pharmacology, Kasturba Medical College, Manipal--576 019.
H N
HN
Bhaskar
Saraswathi L
SL
Udupa
A Laxminarayana
AL
Udupa
D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012879:Skin Physiological Phenomena; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects*
D002121:Calcium Channel Blockers; D005938:Glucocorticoids; D017311:Amlodipine; D003907:Dexamethasone; D009543:Nifedipine