Bone marrow biopsy in Hodgkin's lymphoma.
In the study of patients with Hodgkin's lymphoma (HL) the evaluation of bone marrow biopsy (BMB) can be difficult. In this review we analyze the main diagnostic features and the clinical risk factors of BM involvement. Although the role of BMB is criticized by some authors, its value is irreplaceable in the staging of HL and in the diagnosis of primary medullary HL. The Ann Arbor staging committee criteria should be revised and updated in the light of the current immunohistochemical studies that give a fundamental help in the diagnostic process. A single BMB should be adequate for diagnosis in most instances. In cases of suspicious involvement a controlateral BMB could be performed.
Franco
Vito
V
Istituto di Anatomia e Istologia Patologica, Universita di Palermo, Italy. vfranco@unipa.it
Tripodo
Claudio
C
Rizzo
Aroldo
A
Stella
Mario
M
Florena
Ada Maria
AM
D001856:Bone Marrow Examination; D003937:Diagnosis, Differential; D006689:Hodgkin Disease / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D017410:Practice Guidelines as Topic