Novel mechanism for priming aromatic polyketide synthases.
In this issue of Chemistry & Biology, a novel priming mechanism is proposed for aromatic polyketide biosynthesis, with an iterative type I polyketide synthase generating a starter unit primed for a type II polyketide synthase. This novel priming system participates in hedamycin biosynthesis, a DNA alkylating agent.
Departamento de Biologia Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain.
José A
JA
Salas
D008958:Models, Molecular; D048630:Polyketide Synthases / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation
D048630:Polyketide Synthases