Possible role of the phosphoinositide pathway for signal transduction in changes in the sensitivity of delta-opiate receptors during diabetes mellitus.
We studied the effects of selective delta-opiate receptor agonists and antagonists on the phosphoinositide pathway in lymphocytes from healthy donors and patients with diabetes mellitus. The test compounds probably play a role in changes in the sensitivity to pharmacological substances binding to delta-opiate receptors during diabetes mellitus.
M. Geratsi Erevan State Medical University; Institute of Molecular Biology, Armenian Academy of Sciences, Erevan. agajanov@freenet.am
M I
MI
Agadjanov
G S
GS
Vartanian
Yu V
YV
Tadevosyan
T B
TB
Batikyan
E M
EM
Agadjanova
D001597:Benzylidene Compounds / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000378:metabolism*; D004075:Diglycerides / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism*; D017465:Receptors, Opioid, delta / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
D001597:Benzylidene Compounds; D004075:Diglycerides; D009842:Oligopeptides; D010716:Phosphatidylinositols; D017465:Receptors, Opioid, delta; C068868:naltrindole benzofuran; C059567:deltorphin; C077358:7-benzylidenenaltrexone; D009271:Naltrexone