Glycosylation reaction of unprotected sugars with hydroxyalkylthymine.
Under mild conditions (Lewis acid/solvent/room temperature), the reaction of unprotected glucose, deoxyribose or xylose with hydroxylalkylthymine gives selectively nucleoside analogs with a spacer arm between sugar and base moiety. Experimental conditions (Lewis acid, solvent) for this new strategy leading to nucleoside analogs synthesis are discussed.
Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Université de Limoges, Limoges, France.
Rachida
R
Zerrouki
Luc
L
Billard
Robert
R
Granet
Pierre
P
Krausz
D002241:Carbohydrates / Q000737:chemistry*; D006031:Glycosylation; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry*
D002241:Carbohydrates; D011741:Pyrimidine Nucleosides; D013941:Thymine