Signaling mucins in the (S)limelight.
Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes & Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.
Clevers
Hans
H
Hubrecht Laboratory, Center for Biomedical Genetics, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands.
D000818:Animals; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D020935:MAP Kinase Signaling System; D051379:Mice; D009077:Mucins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D015398:Signal Transduction
D005656:Fungal Proteins; D020690:GTPase-Activating Proteins; D047908:Intracellular Signaling Peptides and Proteins; C076360:MSB2 protein, S cerevisiae; D009077:Mucins; D011108:Polymers; D029701:Saccharomyces cerevisiae Proteins