Disseminated toxoplasmosis after bone marrow transplantation: high-resolution CT appearance.
A 16-year-old female patient, who had undergone bone marrow transplantation 35 days earlier, presented with dry cough, dyspnea, and fever for 4 days. Chest radiography showed poorly-defined bilateral opacities. High-resolution CT revealed bilateral ground glass opacities with superimposed septal thickening and intralobular linear opacities. Laboratory results were nonspecific and empiric treatment with multiple drugs was initiated. The patient had no response to therapy and died 12 days after the admission. At autopsy the patient had disseminated toxoplasmosis with involvement of the central nervous system, myocardium, bone marrow, and lungs.
Escuissato
Dante L
DL
Department of Diagnostic Radiology, University of Paraná, Brazil.
de Aguiar
Rodrigo O C
RO
Gasparetto
Emerson L
EL
Müller
Nestor L
NL
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008174:Lung Diseases, Parasitic / Q000000981:diagnostic imaging* / Q000473:pathology; D009894:Opportunistic Infections / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014123:Toxoplasmosis / Q000000981:diagnostic imaging* / Q000473:pathology