Fetal exposure to PCBs and their hydroxylated metabolites in a Dutch cohort.
Polychlorinated biphenyls (PCBs) are still the most abundant pollutants in wildlife and humans. Hydroxylated PCB metabolites (OH-PCBs) are known to be formed in humans and wildlife. Studies in animals show that these metabolites cause endocrine-related toxicity. The health effects in humans have not yet been evaluated, especially the effect on the fetus and newborn. The aim of this study is to measure the levels of PCBs and OH-PCBs in maternal and cord blood samples in a population with background levels of PCBs. We analyzed 51 maternal and corresponding cord blood samples in the northern part of the Netherlands. The PCB concentrations in maternal plasma ranged from 2 to 293 ng/g lipid, and OH-PCB concentrations from nondetectable (ND) to 0.62 ng/g fresh weight. In cord plasma, PCB concentrations were 1-277 ng/g lipid, and OH-PCB concentrations, ND to 0.47 ng/g fresh weight. The cord versus maternal blood calculated ratio was 1.28 +/- 0.56 for PCBs and 2.11 +/- 1.33 for OH-PCBs, expressed per gram of lipid. When expressed per gram fresh weight, the ratios are 0.32 +/- 0.15 and 0.53 +/- 0.23 for PCBs and OH-PCBs, respectively. A significant correlation between the respective maternal and cord levels for both PCBs and OH-PCBs was found. Our results indicate that OH-PCBs and PCBs are transferred across the placenta to the fetus in concentrations resulting in levels of approximately 50 and 30%, respectively, of those in maternal plasma. More research in humans is needed to evaluate potential negative effects of these endocrine disruptors on the fetus.
University Hospital Groningen, Department of Paediatrics/Beatrix Children's Hospital, PO Box 30.001, 9700 RB Groningen, the Netherlands. norshan@home.nl
Shalini Devi
SD
Soechitram
Maria
M
Athanasiadou
Lotta
L
Hovander
Ake
A
Bergman
Pieter Jan Jacob
PJ
Sauer
D000328:Adult; D015331:Cohort Studies; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006900:Hydroxylation; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009426:Netherlands / Q000453:epidemiology; D010920:Placenta; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D011247:Pregnancy; D012016:Reference Values
D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls