Outcome of uterine embolization and hysterectomy for leiomyomas: results of a multicenter study.
OBJECTIVE
The purpose of this study was to estimate the outcomes of uterine embolization and hysterectomy for uterine leiomyomas. Study design This was a multicenter prospective study of patients who were treated with embolization (n=102 patients) and hysterectomy (n=50 patients) for leiomyomas. Changes in symptoms, complications, and quality of life were measured. The data analysis included linear and logistic regression, the Student t and paired t test, Fisher's exact test, and chi-squared test.


RESULTS
For patients who underwent embolization, there were marked reductions in blood loss scores (P <.001) and menorrhagia questionnaire scores (P <.001) compared with baseline. At 12 months, a larger proportion of the patients who had undergone hysterectomy experienced improved pelvic pain (P=.021). Both groups had marked improvement in other symptoms and quality of life scores, with no difference between groups. Complications were more frequent in patients who underwent hysterectomy (50% vs 27.5%; P=.01).


CONCLUSIONS
Both procedures substantially improved symptoms for most patients, with an advantage for hysterectomy at 12 months for pelvic pain. Serious complications were infrequent in both groups.
Spies
James B
JB
Georgetown University Hospital, Washington DC, USA. spiesj@gunet.georgetown.edu
Cooper
Jay M
JM
Worthington-Kirsch
Robert
R
Lipman
John C
JC
Mills
Benjie B
BB
Benenati
James F
JF
D000328:Adult; D001158:Arteries; D004621:Embolization, Therapeutic / Q000009:adverse effects; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D007889:Leiomyoma / Q000098:blood supply / Q000601:surgery / Q000628:therapy*; D016015:Logistic Models; D008863:Microspheres; D008875:Middle Aged; D011788:Quality of Life; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000098:blood supply / Q000601:surgery / Q000628:therapy*; D014599:Uterus / Q000098:blood supply