Decrease of blue cone sensitivity in acute idiopathic blind spot enlargement syndrome.
OBJECTIVE
To determine the sensitivity of the blue cone system by static perimetry in patients with unilateral acute idiopathic blind spot enlargement (AIBSE) syndrome.


METHODS
Observational case series.


METHODS
Four patients with AIBSE syndrome, aged 16 to 30 years, were studied. Diagnosis of the AIBSE syndrome was based on clinical findings including an enlarged blind spot without corresponding ophthalmoscopic changes of the ocular fundus and with depressed multifocal electoretinograms. The visual sensitivity and mean deviations (MD) were measured by white-on-white (W/W) and blue-on-yellow (B/Y) automated perimetry.


RESULTS
The average difference in the MD between the affected and unaffected eyes was 4.87 +/- 1.51 dB and 13.65 +/- 4.19 dB for W/W and B/Y perimetries, respectively. The difference between the two groups of eyes was significantly greater for B/Y perimetry than that for W/W perimetry (P =.01).


CONCLUSIONS
Our results suggest that the decrease of blue cone sensitivity is diffusely present over the retina in eyes with AIBSE syndrome. We recommend B/Y perimetry as a sensitive measure to detect retinal dysfunction that is not detected by W/W perimetry.
Department of Ophthalmology, Iwate Medical University School of Medicine, Morioka, Iwate, Japan. smachid@clubAA.com
Shigeki
S
Machida
Marie
M
Haga-Sano
Tadashi
T
Ishibe
Junya
J
Kizawa
Yutaka
Y
Tazawa
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000503:physiopathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000503:physiopathology*; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000503:physiopathology*; D012677:Sensation; D013577:Syndrome; D058609:Visual Field Tests; D014794:Visual Fields