Retinoic acid signalling specifies intermediate character in the developing telencephalon.
The organisation of the telencephalon into its major structures depends on its early regionalisation along the dorsoventral axis. Previous studies have provided evidence that sonic hedgehog (SHH) is required for the generation of telencephalic cells of ventral character, and that sequential WNT and fibroblast growth factor (FGF) signalling specifies cells of dorsal telencephalic character. However, the signalling mechanisms that specify telencephalic cells of an intermediate character remain to be defined. We provide evidence here that retinoic acid has a crucial role in specifying telencephalic progenitor cells of intermediate character.
Marklund
Matthew
M
Umeå Center for Molecular Medicine, Building 6M, 4th floor, Umeå University, S-901 87 Umeå, Sweden.
Sjödal
My
M
Beehler
Blake C
BC
Jessell
Thomas M
TM
Edlund
Thomas
T
Gunhaga
Lena
L
D000818:Animals; D002455:Cell Division; D002642:Chick Embryo; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D051379:Mice; D008954:Models, Biological; D009924:Organ Culture Techniques; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D013687:Telencephalon / Q000196:embryology* / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors; D015533:Transcriptional Activation; D014212:Tretinoin / Q000378:metabolism*; D000099260:Empty Spiracles Homeobox Proteins
D018076:DNA, Complementary; D005346:Fibroblast Growth Factors; D018398:Homeodomain Proteins; D014157:Transcription Factors; D014212:Tretinoin; D000099260:Empty Spiracles Homeobox Proteins; C102641:Mrg1 protein, mouse