Successful retrograde transport of fluorescent latex nanospheres in the cerebral cortex of the macaque monkey.
Retrograde axonal transport of latex nanospheres offers a means of delivering chemical agents to a targeted region of the central nervous system (CNS). In this study we performed microinjections of latex nanospheres into the cerebral cortex of cynomolgus monkeys and observed successful retrograde labeling of neurons in the contralateral region. Our data indicate the successful use of this delivery system, reported in studies using other animals, may also be achievable with primates as well.
Sato
Yuki
Y
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa-shi, Chiba, Japan.
Koketsu
Daisuke
D
Ageyama
Naohide
N
Ono
Fumiko
F
Miyamoto
Yusei
Y
Hisatsune
Tatsuhiro
T
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D007840:Latex; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D008845:Microinjections; D043942:Nanotubes
D007840:Latex