Neuro-Behcet disease with predominant involvement of the brainstem.
We report a patient with relapsing-remitting meningoencephalitis secondary to neuro-Behcet disease which resulted in recurrent brainstem encephalitis. MRI revealed increased signal intensity on the proton density and T2-weighted images and gadolinium enhancement during relapses. Autopsy revealed acute on chronic meningoencephalomyelitis involving the entire CNS, which was most marked in the brainstem.
Mirsattari
Seyed M
SM
Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada. smmirsat@uwo.ca
McGinn
Gregory J
GJ
Halliday
William C
WC
D000328:Adult; D001284:Atrophy; D020274:Autoimmune Diseases of the Nervous System / Q000209:etiology / Q000473:pathology; D001528:Behcet Syndrome / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D001921:Brain / Q000473:pathology; D001933:Brain Stem / Q000473:pathology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008590:Meningoencephalitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D013116:Spinal Cord / Q000473:pathology; D013290:Streptococcal Infections / Q000150:complications; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011241:Prednisone