The sensitivity and specificity of the OralCDx technique: evaluation of 103 cases.
In this study, we compared 103 OralCDx results with the histological findings of 96 clinical sites in 80 patients (33 females; 64.3+/-13.7 years and 47 males; 53.2+/-11.5 years). The histological findings were classified as follows: compatible with oral leukoplakia (OL; n = 60) or oral lichen planus (OLP; n = 17), both without dysplasia; dysplasia in OL or OLP (n = 9); and oral squamous cell carcinoma (OSCC; n = 17). There were seven (6.8%) specimens with an inadequate cell count. Overall, the sensitivity of the OralCDx technique to detect dysplasia and OSCC was 92.3% (95% CI: 74.9-99.1%), and the specificity was 94.3% (95% CI: 86.0-98.4%). The positive likelihood ratio (LR+) was 16.2 (95% CI: 6.2-42.1) and the negative likelihood ratio (LR-) was 0.08 (95% CI: 0.02-0.31). In conclusion, these figures are in agreement with previously published data and support the use of OralCDx as a screening tool of oral lesions, but further trials are still necessary.
Department of Oral Surgery and Dental Radiology, Zentrum für Zahnmedizin, Campus Virchow, Charité--Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. christian.scheifele@charite.de
Christian
C
Scheifele
Andrea-Maria
AM
Schmidt-Westhausen
Thomas
T
Dietrich
Peter A
PA
Reichart
D001706:Biopsy / Q000379:methods; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000175:diagnosis / Q000473:pathology*; D017676:Lichen Planus, Oral / Q000175:diagnosis / Q000473:pathology; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology; D012680:Sensitivity and Specificity