Total serum cholesterol and suicidality in anorexia nervosa.
OBJECTIVE
No published study has evaluated the relationship between serum cholesterol and suicidality in anorexia nervosa (AN).


OBJECTIVE
To assess psychiatric and nutritional correlates of serum cholesterol in a sample of AN patients.


METHODS
Serum cholesterol and nutritional status were evaluated in a sample of 74 AN patients, before starting any type of refeeding. All subjects underwent a structured clinical interview and completed the Hopkins Symptom Checklist.


RESULTS
Subjects who reported previous suicide attempts, impulsive self-injurious behavior, or current suicidal ideation showed significantly lower cholesterol levels than subjects without suicidality. Cholesterol levels were negatively correlated with the severity of depressive symptoms in all the patients with the exception of those with recurrent binge eating. A multivariate analysis showed that the relationships between cholesterol levels and suicidal behavior and ideation do not seem to be affected by the nutritional and metabolic factors considered in the study.


CONCLUSIONS
Notwithstanding the influence of important metabolic factors affecting cholesterolemia in AN, our research tends to confirm previous studies that have found an association between low cholesterol levels and suicidality.
Department of Neuroscience, University of Padua, Padua, Italy.
Angela
A
Favaro
Lorenza
L
Caregaro
Lorenza
L
Di Pascoli
Francesca
F
Brambilla
Paolo
P
Santonastaso
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000175:diagnosis / Q000523:psychology*; D015992:Body Mass Index; D002032:Bulimia / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D002784:Cholesterol / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009752:Nutritional Status; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D016728:Self-Injurious Behavior / Q000453:epidemiology; D012720:Severity of Illness Index; D013405:Suicide / Q000523:psychology*; D013406:Suicide, Attempted / Q000706:statistics & numerical data
D002784:Cholesterol