Predicting synthetic accessibility: application in drug discovery and development.
The estimation and use of synthetic accessibility in the drug discovery process is discussed. A distinction is drawn between synthetic feasibility and accessibility and the practical uses of an accessibility score are examined. Various techniques used in the estimation of accessibility are described and their utility and potential accuracy compared.
SignalGene Inc., 335 Laird Road - Unit 2, Guelph, Ontario, N1G 4P7 Canada. jcbaber@quoth.co.uk
J C
JC
Baber
M
M
Feher
D003198:Computer Simulation; D015195:Drug Design; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry
D004364:Pharmaceutical Preparations