Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study).
We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
Gysèle S
GS
Bleumink
Ingrid
I
Rietveld
Joop A M J L
JA
Janssen
Elisabeth F C
EF
van Rossum
Jaap W
JW
Deckers
Albert
A
Hofman
Jacqueline C M
JC
Witteman
Cornelia M
CM
van Duijn
Bruno H Ch
BH
Stricker
D017677:Age Distribution; D000483:Alleles; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D020022:Genetic Predisposition to Disease; D006333:Heart Failure / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011379:Prognosis; D011401:Promoter Regions, Genetic; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D016019:Survival Analysis
D007334:Insulin-Like Growth Factor I