Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity.
We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 > or = CD10 > or = CD10 x CD3F1 > CD10 x B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 x B6F1 animals and dominant in CD10 x CD3F1 animals.
California Institute for Medical Research, and Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, 95128, USA. clemons@cimr.org
Karl V
KV
Clemons
Jimmy L
JL
Spearow
Rachana
R
Parmar
Marife
M
Espiritu
David A
DA
Stevens
D000818:Animals; D002176:Candida albicans / Q000472:pathogenicity*; D002181:Candidiasis, Vulvovaginal / Q000235:genetics* / Q000382:microbiology / Q000503:physiopathology*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D020022:Genetic Predisposition to Disease; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains
D004967:Estrogens