Evaluation of Xenostrip-Tv, a rapid diagnostic test for Trichomonas vaginalis infection.
An immunochromatographic strip test, Xenostrip-Tv, was compared to wet mount and PCR for the diagnosis of Trichomonas vaginalis infection in women. Of 428 specimens tested, 54 (12.6%) were positive by an "expanded gold standard," defined as either a positive wet mount and PCR test with primers TVK3 and TVK7 and/or a positive PCR test confirmed by a second PCR assay with primers TVA5-1 and TVA6; 26 (6%) were positive by wet mount, and 36 (8.4%) were positive by Xenostrip-Tv test. Since the Xenostrip-Tv test is rapid and easy to perform and proved to be more sensitive than wet mount, it should be considered as an alternative to wet mount for point-of-care diagnosis of trichomoniasis, especially in settings where microscopy is impractical.
Pillay
A
A
Sexually Transmitted Infections Branch, Division of Sexually Transmitted Diseases Prevention, NCHSTP, Centers for Disease Control and Prevention, 1600 Clifton Rd., MS-G39, Atlanta, GA 30333, USA. Apillay@cdc.gov
Lewis
J
J
Ballard
R C
RC
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D011237:Predictive Value of Tests; D011934:Reagent Strips; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014245:Trichomonas Infections / Q000175:diagnosis*; D014246:Trichomonas vaginalis / Q000302:isolation & purification*
D017931:DNA Primers; D011934:Reagent Strips