Neuro-Behcet disease with predominant involvement of the brainstem.
We report a patient with relapsing-remitting meningoencephalitis secondary to neuro-Behcet disease which resulted in recurrent brainstem encephalitis. MRI revealed increased signal intensity on the proton density and T2-weighted images and gadolinium enhancement during relapses. Autopsy revealed acute on chronic meningoencephalomyelitis involving the entire CNS, which was most marked in the brainstem.
Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada. smmirsat@uwo.ca
Seyed M
SM
Mirsattari
Gregory J
GJ
McGinn
William C
WC
Halliday
D000328:Adult; D001284:Atrophy; D020274:Autoimmune Diseases of the Nervous System / Q000209:etiology / Q000473:pathology; D001528:Behcet Syndrome / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D001921:Brain / Q000473:pathology; D001933:Brain Stem / Q000473:pathology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008590:Meningoencephalitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D013116:Spinal Cord / Q000473:pathology; D013290:Streptococcal Infections / Q000150:complications; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011241:Prednisone