The response of the apical turn of cochlea modeled with a tuned amplifier with negative feedback.
In an earlier study [Hear. Res. 149 (2000) 55] velocity amplitudes of the outer Hensen's cell (HC) and basilar membrane (BM) were measured before, and at different times, after, sacrificing the animal. The velocity amplitude changed in a way that was characteristic of a negative feedback amplifier. A simple negative feedback amplifier model was proposed to explain the magnitude of the HC and BM velocity changes at CF. In the experiment tuning changed as well, both at the HC and BM. The model has now been extended to include tuning changes. The model response is compared with the experimental observations. The model is able to account quantitatively for the following experimental observations: (i) At the HC the tuning broadens and velocity decreases slowly after sacrifice. (ii) At the BM tuning sharpens and velocity increases at a faster rate. (iii) The velocity increase at BM is much larger than the decrease at HC.
Department of Otolaryngology and Head and Neck Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. smk3@columbia.edu
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Khanna
D000818:Animals; D001489:Basilar Membrane / Q000502:physiology; D003051:Cochlea / Q000166:cytology / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D006801:Humans; D008432:Mathematical Computing; D008954:Models, Biological; D009925:Organ of Corti / Q000502:physiology; D014732:Vibration