Doxorubicin-poly(acrylic acid) complexes: interaction with liposomes.
Complexation of antitumor drug, doxorubicin (DOX), with poly(acrylic acid) (PAA) in buffer solutions was examined. The DOX-to-PAA binding was governed by electrostatic and stacking interactions resulting in a complex of characteristic composition with a PAA/DOX = 1.6 molar ratio. Sizes of the complex particles were found to lie in 600-900-nm range. However, the particles were able to interact with small neutral egg yolk lecithin liposomes (80-100 nm in diameter), a ternary DOX/PAA/liposome complex being formed. The observations and conclusions we made may be useful for interpreting biological effects of polymer-based bioactive constructs.
Kitaeva
M V
MV
School of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119899, Leninskie Gory, Russian Federation.
Melik-Nubarov
N S
NS
Menger
F M
FM
Yaroslavov
A A
AA
D000180:Acrylic Resins / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D004530:Egg Yolk / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D055672:Static Electricity; D013499:Surface Properties
D000180:Acrylic Resins; D008081:Liposomes; D010713:Phosphatidylcholines; C006903:carbopol 940; D004317:Doxorubicin