Physiology of GDF9 and BMP15 signalling molecules.
Two related oocyte-derived members of the transforming growth factor-beta (TGF-beta) superfamily, namely growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15, also known as GDF9B), have recently been shown to be essential for ovarian follicular growth. In addition, both proteins have been shown to regulate ovulation rate in sheep, and although it is evident that these growth factors interact both with one another and with other intra- and extra-ovarian factors, the precise mechanisms by which they influence follicular growth and ovulation rate have not been thoroughly elucidated.
Juengel
J L
JL
AgResearch, Wallaceville Animal Research Centre, Ward Street, P.O. Box 40063, Upper Hutt, New Zealand. jenny.juengel@agresearch.co.nz
Bodensteiner
K J
KJ
Heath
D A
DA
Hudson
N L
NL
Moeller
C L
CL
Smith
P
P
Galloway
S M
SM
Davis
G H
GH
Sawyer
H R
HR
McNatty
K P
KP
D000818:Animals; D055430:Bone Morphogenetic Protein 15; D005260:Female; D005298:Fertility; D006107:Granulosa Cells / Q000187:drug effects / Q000502:physiology; D055429:Growth Differentiation Factor 9; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009865:Oocytes / Q000378:metabolism*; D006080:Ovarian Follicle / Q000187:drug effects / Q000254:growth & development; D010060:Ovulation / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D012756:Sheep / Q000235:genetics; D013799:Theca Cells / Q000187:drug effects / Q000502:physiology
C525902:Bmp15 protein, mouse; D055430:Bone Morphogenetic Protein 15; C525898:Gdf9 protein, mouse; D055429:Growth Differentiation Factor 9; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger