Effect of clopidogrel pretreatment on periprocedural rise in C-reactive protein after percutaneous coronary intervention.
This study sought to determine the effect of clopidogrel pretreatment on the increase in C-reactive protein (CRP) after percutaneous coronary intervention. Clopidogrel pretreatment attenuated the periprocedural increase in CRP by 65% and was independently associated with an attenuation in the CRP increase in a multivariate model.
Vivekananthan
Deepak P
DP
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA.
Bhatt
Deepak L
DL
Chew
Derek P
DP
Zidar
Frank J
FJ
Chan
Albert W
AW
Moliterno
David J
DJ
Ellis
Stephen G
SG
Topol
Eric J
EJ
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D002097:C-Reactive Protein / Q000032:analysis / Q000187:drug effects*; D016022:Case-Control Studies; D000077144:Clopidogrel; D015331:Cohort Studies; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D023903:Coronary Restenosis / Q000517:prevention & control*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D013988:Ticlopidine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D016896:Treatment Outcome
D010975:Platelet Aggregation Inhibitors; D002097:C-Reactive Protein; D000077144:Clopidogrel; D013988:Ticlopidine