Chemical constituents of Millettia taiwaniana: structure elucidation of five new isoflavonoids and their cancer chemopreventive activity.
We describe the isolation and identification of five new isoflavonoids, millewanins A (1), B (2), C (3), D (4), and E (5), together with six known isoflavonoids and three rotenoids, from the stems of Millettia taiwaniana collected in Japan. The major component, auriculasin (6), exhibited significant inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that 6 might be a valuable antitumor promoter.
Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
Chihiro
C
Ito
Masataka
M
Itoigawa
Naoki
N
Kojima
Harukuni
H
Tokuda
Tetsurou
T
Hirata
Hoyoku
H
Nishino
Hiroshi
H
Furukawa
D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D051379:Mice; D033641:Millettia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012867:Skin / Q000187:drug effects
D016588:Anticarcinogenic Agents; D007529:Isoflavones