The potential of lipid emulsion for ocular delivery of lipophilic drugs.
For nearly a decade, oil-in-water lipid emulsions containing either anionic or cationic droplets have been recognized as an interesting and promising ocular topical delivery vehicle for lipophilic drugs. The aim of this review is to present the potential of lipid emulsions for ocular delivery of lipophilic drugs. The review covers an update on the state of the art of incorporating the lipophilic drugs, a brief description concerning the components and the classification of lipid emulsions. The ocular fate following topical instillation, safety evaluation experiments and the applications of lipid emulsions are thoroughly discussed.
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Punjab, India.
Shunmugaperumal
S
Tamilvanan
Simon
S
Benita
D000818:Animals; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000009:adverse effects / Q000737:chemistry*; D009883:Ophthalmic Solutions / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D014867:Water / Q000737:chemistry
D004655:Emulsions; D005079:Excipients; D008055:Lipids; D009883:Ophthalmic Solutions; D004364:Pharmaceutical Preparations; D014867:Water