Proton spectroscopy detected myoinositol in children with traumatic brain injury.
Previous studies have shown that proton magnetic resonance spectroscopy (MRS) is useful in predicting neurologic prognosis in children with traumatic brain injury (TBI). Reductions in N-acetyl derived metabolites and presence of lactate have been predictive of poor outcomes. We examined another spectroscopy metabolite, myoinositol (mI), to determine whether it is altered after TBI. Found primarily in astrocytes, mI functions as an osmolyte and is involved in hormone response pathways and protein-kinase C activation. Myoinositol is elevated in the newborn brain and is increased in a variety of diseases. We studied 38 children (mean age 11 y; range 1.6-17 y) with TBI using quantitative short echo time occipital gray and parietal white matter proton MRS at a mean of 7 d (range 1-17 d) after injury. We found that occipital gray matter mI levels were increased in children with TBI (4.30 +/- 0.73) compared with controls (3.53 +/- 0.48; p = 0.003). We also found that patients with poor outcomes 6-12 mo after injury had higher mI levels (4.78 +/- 0.68) than patients with good outcomes (4.15 +/- 0.69; p < 0.05). Myoinositol is elevated after pediatric TBI and is associated with a poor neurologic outcome. The reasons for its elevation remain unclear but may be due to astrogliosis or to a disturbance in osmotic function.
Division of Child Neurology, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA. sashwal@ahs.llumc.edu
Stephen
S
Ashwal
Barbara
B
Holshouser
Karen
K
Tong
Teresa
T
Serna
Renatta
R
Osterdock
Matthew
M
Gross
Daniel
D
Kido
D000293:Adolescent; D015415:Biomarkers; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005911:Gliosis / Q000378:metabolism / Q000473:pathology; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007223:Infant; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013057:Spectrum Analysis
D015415:Biomarkers; D005973:Glutamine; D018698:Glutamic Acid; D007294:Inositol