Feeding induces expression of heat shock proteins that reduce oxidative stress.
Heat shock proteins (Hsps) are induced in response to various kinds of environmental and physiological stresses. However, it is unclear whether Hsps play roles in protecting cells in the digestive organs against xenobiotic chemicals. Here, we found that feeding induces expression of a set of Hsps specifically in the mouse liver and intestine by activating heat shock transcription factor 1 (HSF1). In the liver, HSF1 is required to suppress toxic effects of electrophiles, which are xenobiotic chemicals causing oxidative stress. We found that overexpression of Hsp27, which elevates cellular glutathione level, promotes survival of culture cells exposed to electrophiles. These results suggest a novel mechanism of cell protection against xenobiotic chemicals in the food.
Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube 775-8505, Japan.
Kensaku
K
Katsuki
Mitsuaki
M
Fujimoto
Xiu-Ying
XY
Zhang
Hanae
H
Izu
Eiichi
E
Takaki
Yukio
Y
Tanizawa
Sachiye
S
Inouye
Akira
A
Nakai
D000821:Animal Feed; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D004435:Eating / Q000502:physiology*; D005978:Glutathione / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006367:HeLa Cells; D000076249:Heat Shock Transcription Factors; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009928:Organ Specificity; D018384:Oxidative Stress / Q000502:physiology*; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C000619706:HSF1 protein, human; D018840:HSP70 Heat-Shock Proteins; D000076249:Heat Shock Transcription Factors; D006360:Heat-Shock Proteins; D014157:Transcription Factors; D005978:Glutathione