Low-level gonosomal mosaicism in women undergoing ICSI cycles.
OBJECTIVE
Females with low-level gonosomal mosaicism (LLGM) scheduled for ICSI were retrospectively analyzed and compared to control groups. The prevalence of this mosaicism as well as its impact for an ICSI treatment were evaluated.


METHODS
Routine cytogenetic analysis was done in 891 females scheduled for ICSI treatment. For comparison 294 females with recurrent abortions and 104 women with clinical or cytogenetical affected children, who also had routine chromosome analysis, were acquired.


RESULTS
In the ICSI group the incidence of LLGM was significantly lower compared to the group of females with recurrent abortions (3.9% vs. 8.5%, p < 0.01). The incidence was similar between the groups of ICSI females and females with cytogenetical or clinically affected children (5.8%, p = 0.43). Neither anamnestic factors nor outcome parameters were different between females with and without LLGM undergoing ICSI.


CONCLUSIONS
There is no higher incidence of LLGM in females undergoing ICSI. In those who show LLGM, fertility capacity is not reduced.
Voigt
R
R
Department of Human Genetics, University Clinic of Schleswig Holstein, Campus Lübeck, Germany.
Schröder
A K
AK
Hinrichs
E
E
Diedrich
K
K
Schwinger
E
E
Ludwig
M
M
D000026:Abortion, Habitual / Q000235:genetics; D000328:Adult; D002869:Chromosome Aberrations; D015331:Cohort Studies; D020732:Cytogenetic Analysis; D003582:Cytogenetics / Q000379:methods; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007247:Infertility, Female / Q000628:therapy*; D007621:Karyotyping; D009030:Mosaicism; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome