Ocular penetration of grepafloxacin after intravitreal administration in albino and pigmented rabbits.
Ocular penetration of grepafloxacin into several ocular tissues was determined in albino and pigmented rabbits following a single intravitreal administration. After administration, grepafloxacin was detected in all ocular tissues studied in both breeds of rabbits. The superior mean penetration ratios were found in the chorioretina and lens of albino rabbits, and in the chorioretina, iris and lens of pigmented rabbits. A significantly greater penetration of grepafloxacin was found in the chorioretina and iris of the pigmented rabbits than in those of the albino rabbits. As a final conclusion, grepafloxacin detected in different ocular structures could attain therapeutic concentrations against a variety of ocular conditions.
Department of Pharmacology and Physiology, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain.
C
C
Solans
M A
MA
Bregante
M A
MA
Garcia
S
S
Perez
D000417:Albinism / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D005123:Eye / Q000737:chemistry / Q000378:metabolism*; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007498:Iris / Q000378:metabolism; D010879:Piperazines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D012160:Retina / Q000378:metabolism; D012590:Sclera / Q000378:metabolism
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D010879:Piperazines; C075375:grepafloxacin