Does random X-inactivation in mammals reflect a random choice between two X chromosomes?
Inactivation of the maternal or paternal X chromosome in a mammalian embryonic XX cell is believed to involve random choice between the two X's. We propose two alternative models. One suggests that choice is not random, while the other is consistent with random choice, but not one between two X's.
Williams
Benjamin R
BR
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Wu
Chao-Ting
CT
D000818:Animals; D004303:Dosage Compensation, Genetic; D008322:Mammals / Q000235:genetics*; D008954:Models, Biological; D013269:Stochastic Processes; D014960:X Chromosome / Q000235:genetics*