GeneNetwork: an interactive tool for reconstruction of genetic networks using microarray data.
Inferring genetic network architecture from time series data generated from high-throughput experimental technologies, such as cDNA microarray, can help us to understand the system behavior of living organisms. We have developed an interactive tool, GeneNetwork, which provides four reverse engineering models and three data interpolation approaches to infer relationships between genes. GeneNetwork enables a user to readily reconstruct genetic networks based on microarray data without having intimate knowledge of the mathematical models. A simple graphical user interface enables rapid, intuitive mapping and analysis of the reconstructed network allowing biologists to explore gene relationships at the system level.


BACKGROUND
Download from http://genenetwork.sbl.bc.sinica.edu.tw/.


BACKGROUND
Supplement documentation of algorithms for the four approaches is downloadable at the above location.
Wu
Chia-Chin
CC
Institute of Biological Chemistry and Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Huang
Hsuan-Cheng
HC
Juan
Hsueh-Fen
HF
Chen
Shui-Tein
ST
D000465:Algorithms; D003196:Computer Graphics; D003198:Computer Simulation; D020869:Gene Expression Profiling / Q000379:methods*; D008957:Models, Genetic; D009716:Numerical Analysis, Computer-Assisted; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology*; D012984:Software; D014584:User-Computer Interface