Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown.
Mihalik
R
R
Imre
G
G
Petak
I
I
Szende
B
B
Kopper
L
L
D000590:Amino Acid Chloromethyl Ketones / Q000493:pharmacokinetics; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D002401:Cathepsin B / Q000187:drug effects* / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004150:Dipeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism; D009336:Necrosis / Q000139:chemically induced* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D019311:Staurosporine / Q000494:pharmacology
D000590:Amino Acid Chloromethyl Ketones; C400541:CA 074 methyl ester; D061945:Caspase Inhibitors; D004151:Dipeptides; D004791:Enzyme Inhibitors; C476093:z-Val-Ala-Asp(Ome)-fluoromethylketone; D004150:Dipeptidases; D020169:Caspases; D002401:Cathepsin B; D019311:Staurosporine