Plasma quality after whole-blood filtration depends on storage temperature and filter type.
The study evaluated the quality of plasma obtained after whole-blood filtration with four different polyester filters and one polyurethane filter. The activities of coagulation factors and proteinase inhibitors were not or only negligibly affected by filtration, in all experiments. Filtration did not increase markers of clotting and fibrinolysis. Only a strong neutrophil and complement activation was observed, which depended on the type of filter and whole-blood storage conditions. However, as neutrophil elastase-specific degradation products did not increase and the complement-derived anaphylatoxin C3a was found in its inactivated form, C3a-desArg, these filtration-dependent changes apparently have little impact on the therapeutic quality of whole-blood-filtered fresh frozen plasma for transfusion.
Paul-Ehrlich-Institut, Langen, Germany. heima@pei.de
M
M
Heiden
U
U
Salge
R
R
Henschler
H-U
HU
Pfeiffer
P
P
Volkers
J
J
Hesse
W
W
Sireis
R
R
Seitz
D000991:Antithrombins / Q000032:analysis; D001771:Blood Banks / Q000592:standards*; D016913:Blood Component Transfusion / Q000592:standards*; D001798:Blood Proteins / Q000032:analysis; D005337:Fibrin / Q000032:analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005374:Filtration; D006801:Humans; D010949:Plasma; D011091:Polyesters; D011140:Polyurethanes; D018709:Statistics, Nonparametric; D013696:Temperature; D014361:Trypsin Inhibitors / Q000032:analysis; D000979:alpha-2-Antiplasmin / Q000032:analysis
D000991:Antithrombins; D001798:Blood Proteins; D005338:Fibrin Fibrinogen Degradation Products; D011091:Polyesters; D011140:Polyurethanes; D014361:Trypsin Inhibitors; D000979:alpha-2-Antiplasmin; C036309:fibrin fragment D; D005337:Fibrin