Challenging diagnosis--icterus associated with a single perforating duodenal ulcer after long-term nonsteroidal antiinflammatory drug administration in a dog.
A dog developed icterus, vomiting, and anorexia 2 wk after orthopedic surgery and treatment with meloxicam for approximately 1 y. Exploratory laparotomy revealed a single perforated duodenal ulcer. The most likely cause of the hyperbilirubinemia was intrahepatic cholestasis resulting from peritonitis associated with the perforation.
Duerr
Felix M
FM
University of Saskatchewan, Veterinary Teaching Hospital, Western College of Veterinary Medicine, Department of Small Animal Clinical Sciences, 52 Campus Drive, Saskatoon, Saskatchewan. felix.duerr@usask.ca
Carr
Anthony P
AP
Bebchuk
Trevor N
TN
Pople
Neil C
NC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D007565:Jaundice / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008297:Male; D000077239:Meloxicam; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000662:veterinary; D010439:Peptic Ulcer Perforation / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D013843:Thiazines / Q000009:adverse effects* / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam