Novel N-aryl and N-heteroaryl sulfamide synthesis via palladium cross coupling.
A novel and efficient synthesis of N-aryl and N-heteroaryl sulfamides via an intermolecular palladium-catalyzed coupling process has been developed. The reactions proceeded with good to excellent yields and were tolerant of a wide range of functional groups. [reaction: see text]
Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, LE11 5RH, United Kingdom. lilian.alcaraz@astrazeneca.com
Lilian
L
Alcaraz
Colin
C
Bennion
James
J
Morris
Premji
P
Meghani
Stephen M
SM
Thom