Keratosis follicularis of the oral mucosa with oral squamous cell carcinoma.
Darier's disease or keratosis follicularis is a genodermatosis which may involve the oral mucosa. Malignant degeneration is rare. We report the first case of the combined manifestation of oral keratosis follicularis and oral squamous cell carcinoma and discuss the possible involvement of ATP2A2 (located in 12q23-24.1) which encodes the sarco/endoplasmic reticulum Ca(2+)-ATP isoform 2 (SERCA2), in the pathogenesis.
Dolci
Marco
M
Maxillofacial Surgery Section, University of Chieti, Italy.
Favia
Gianfranco
G
Scully
Crispian
C
Di Alberti
Luca
L
D000252:Calcium-Transporting ATPases / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D007644:Darier Disease / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000150:complications*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases
D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; C506946:ATP2A2 protein, human; D000252:Calcium-Transporting ATPases