[Analysis of etiological factors of pseudo-epitheliomatous granuloma after cutaneous wound healing: a report of 11 cases of patients with this lesion].
OBJECTIVE
To explore the pathogenetic mechanism, clinical and pathological characteristics, and prevention and treatment of pseudo-epitheliomatous granuloma after skin wound healing.


METHODS
The clinical information and the treatment results of pseudo-epitheliomatous granuloma occurring in 11 patients (age 1-67 years) were reviewed and analyzed, their tissue specimens were used for microbial examination and histological observation.


RESULTS
Some bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus hemolyticus B, and Streptococcus faecalis could be found in the culture of pseudo-epitheliomatous granuloma. The maJority of these bacteria was tolerant to celbenin but sensitive to vancomycin. The lesions were excised, and the wounds were covered with skin grafting or skin flap, supplemented by local of vancomycin to prevent recurrence of the lesion. Histological examination revealed in pseudo-epitheliomatous granuloma with long epithelial peduncle encapsulating granulation tissue like honeycomb, in which there were many capillaries, macrophages, lymphocytes and mast cells, with only a small amount of extracellular matrix.


CONCLUSIONS
The main pathogenesis of pseudo-epitheliomatous granuloma formation might be improper treatment of wound in earlier period and infection of drug resistant bacteria. Surgical debridement followed by skin coverage and local inJection of vancomycin could be effective and curative.
Taizhou Institute of Wound and Surgery Plastic, Taizhou Fourth People's Hospital, Taizhou 225300, Jiangsu, China. jdybs@163.com
Du-yin
DY
Jiang
Xiao-bing
XB
Fu
Zhi-yong
ZY
Sheng
Wei
W
Chen
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003646:Debridement; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012867:Skin / Q000293:injuries* / Q000473:pathology; D016038:Skin Transplantation; D014640:Vancomycin / Q000627:therapeutic use; D014945:Wound Healing; D014946:Wound Infection / Q000150:complications; D055815:Young Adult
D000900:Anti-Bacterial Agents; D014640:Vancomycin