[Agonists and antagonists of mineralocorticoids. The relation between structure and activity].
The mechanism of action of aldosterone and its links with the mineralocorticoids receptor (MR) are described. The physiologic importance of the MR structure is emphasized, in relation with the preferential activation of the receptor by aldosterone.
Fagart
J
J
Inserm 478, faculté de médecine Xavier-Bichat, 16, rue Henri-Huchard, 75780 Paris cedex 18, France.
Pinon
G M
GM
Rafestin-Oblin
M E
ME
D000450:Aldosterone / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D008901:Mineralocorticoids / Q000494:pharmacology*; D018161:Receptors, Mineralocorticoid / Q000502:physiology*; D013329:Structure-Activity Relationship
D008024:Ligands; D008901:Mineralocorticoids; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone