MT1-MMP: an enzyme with multidimensional regulation.
The activity of membrane-type 1 matrix metalloproteinase (MT1-MMP) is a double-edged sword--it is crucial for both physiological processes and disease progression. MT1-MMP modifies various cellular functions and it is, sthus, regulated precisely as a proteinase and as a membrane protein. Recent studies have further revealed that the function of MT1-MMP is modified and regulated by O-glycosylation, interaction with CD44, internalization and recycling. Such multidimensional mechanisms enable MT1-MMP to be regulated spatially and temporally, and are essential for its proper functioning on the cell surface.
Itoh
Yoshifumi
Y
Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, UK.
Seiki
Motoharu
M
D002462:Cell Membrane / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D018960:Hyaluronan Receptors / Q000502:physiology; D053504:Matrix Metalloproteinases, Membrane-Associated; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism*
D018960:Hyaluronan Receptors; D008565:Membrane Proteins; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases