Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: cluster randomised controlled trial.
BACKGROUND
Non-compliance attenuates the efficacy of treatments for physical and mental disorders.


OBJECTIVE
To assess the effectiveness of a medication management training package for community mental health nurses (CMHNs) in improving compliance and clinical outcomes in patients with schizophrenia.


METHODS
Pragmatic randomised controlled trial. Sixty CMHNs in geographical clusters were assigned randomly to medication management training or treatment as usual. Each CMHN identified two patients on their case-load who were assessed at baseline and again after 6 months by a research worker. The primary efficacy outcome of interest was psychopathology, measured using the Positive and Negative Syndrome Scale (PANSS).


RESULTS
Nurses who had received medication management training produced a significantly greater reduction in patients'overall psychopathology compared with treatment as usual at the end of the 6-month study period (change in PANSS total scores: medication management -16.62, treatment as usual 1.17; difference -17.79; 95% CI -24.12 to -11.45; P<0.001).


CONCLUSIONS
Medication management training for CMHNs is effective in improving clinical outcomes in patients with schizophrenia.
Gray
Richard
R
PO 30, Health Services Research Department, Institute of Psychiatry, De Crespigny Park, London SE5 8AF. R.Gray@iop.kcl.ac.uk
Wykes
Til
T
Edmonds
Melisa
M
Leese
Morven
M
Gournay
Kevin
K
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016000:Cluster Analysis; D003152:Community Health Nursing / Q000193:education*; D004509:Education, Nursing, Continuing; D006801:Humans; D007318:Inservice Training; D008131:London; D010349:Patient Compliance; D012559:Schizophrenia / Q000188:drug therapy / Q000451:nursing*; D016037:Single-Blind Method; D016896:Treatment Outcome
D014150:Antipsychotic Agents