Comparative genomics: prediction of the ciliary and basal body proteome.
Defects in mammalian cilia lead to a range of diseases, but our understanding of the composition of these organelles and of the basal bodies from which they arise is limited. Two recent studies used comparative genomics to predict the ciliary and basal body proteomes, providing datasets that are rich sources of human disease gene candidates.
Pazour
Gregory J
GJ
Program in Molecular Medicine, University of Massachusetts Medical School, Biotech II, Suite 213, 373 Plantation St., Worcester, Massachusetts 01605, USA. gregory.pazour@umassmed.edu
D000818:Animals; D001419:Bacteria / Q000235:genetics; D020788:Bardet-Biedl Syndrome / Q000235:genetics; D002923:Cilia / Q000235:genetics* / Q000502:physiology*; D030541:Databases, Genetic; D056890:Eukaryota / Q000235:genetics; D005407:Flagella / Q000235:genetics / Q000502:physiology; D023281:Genomics; D006801:Humans; D010802:Phylogeny; D010944:Plants / Q000235:genetics; D020543:Proteome / Q000235:genetics*; D012107:Research Design
D020543:Proteome