Effects of coasting on the outcome of intracytoplasmic sperm injection-embryo transfer cycles.
OBJECTIVE
To determine the effects of 'coasting' on the outcome of controlled ovarian hyperstimulation (COH) and intracytoplasmic sperm injection-embryo transfer (ICSI-ET).


METHODS
Retrospective study.


METHODS
IVF Centre, Ozel Ege Tup Bebek Merkezi, Izmir, Turkey.


METHODS
Twenty-six coasted and 52 non-coasted COH and ICSI-ET patients were enrolled in this retrospective study.


METHODS
Coasted patients were enrolled consecutively during the study period, and two non-coasted controls were selected from our database for each coasted patient. Coasting was decided when serum oestradiol level was > or = 4000 pg/mL. Groups were compared using chi2 and Mann-Whitney U-tests for statistical analysis.


METHODS
Number of oocytes collected, metaphase II (MII) oocytes and cleaving embryos, the fertilisation rate and clinical pregnancy rate were the main outcome measures.


RESULTS
Number of oocytes collected, number of MII oocytes, number of cleaving embryos, fertilisation rate and clinical pregnancy rate for the coasted and non-coasted groups were 15.5 +/- 5.2 and 14.0 +/- 7.1, 9.7 +/- 4.8 and 9.3 +/- 3.9, 6.8 +/- 3.9 and 5.8 +/- 3.1, 0.85 +/- 0.18 and 0.78 +/- 0.18, 13/26 and 24/52, respectively; these differences were not statistically significant. None of the patients in the coasted group were hospitalised for signs or findings of severe ovarian hyperstimulation syndrome.


CONCLUSIONS
Coasting does not adversely affect the number and the function of mature oocytes and the clinical pregnancy rate.
IVF Department, Ozel Ege Tup Bebek Merkezi, Izmir, Turkey. sebnem.aktan@deu.edu.tr
Erdal
E
Aktan
Kaan
K
Bozkurt
Dilek
D
Ozer
Sait
S
Yucebilgin
Nedim
N
Karadadas
Onur
O
Bilgin
D004624:Embryo Transfer; D005260:Female; D006728:Hormones / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D009865:Oocytes / Q000378:metabolism; D016471:Ovarian Hyperstimulation Syndrome / Q000628:therapy*; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D016896:Treatment Outcome; D014421:Turkey
D006728:Hormones