Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms.
The present study was undertaken to evaluate the cardioprotective potential of Curcuma longa (Turmeric) in the ischemia-reperfusion (I/R) model of myocardial infarction (MI). Wistar rats were divided into three groups and received saline orally (sham, control I/R group) and Curcuma longa 100 mg/kg (CL-100 treated group) respectively for one month. On the 31st day, rats of the control I/R and Cl treated groups were subjected to 45 min of occlusion of the LAD coronary artery and were thereafter reperfused for 1 h. I/R resulted in significant cardiac necrosis, depression in left ventricular function, decline in antioxidant status and elevation in lipid perodixation in the control I/R group as compared to sham control. Myocardial infarction produced after I/R was significantly reduced in the Cl treated group. Cl treatment resulted in restoration of the myocardial antioxidant status and altered hemodynamic parameters as compared to control I/R. Furthermore, I/R-induced lipid peroxidation was significantly inhibited by Cl treatment. The beneficial cardioprotective effects also translated into the functional recovery of the heart. Cardioprotective effect of Cl likely results from the suppression of oxidative stress and correlates with the improved ventricular function. Histopathological examination further confirmed the protective effects of Cl on the heart.
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029.
Ipseeta
I
Mohanty
Dharamvir
D
Singh Arya
Amit
A
Dinda
Sujata
S
Joshi
Keval Kishan
KK
Talwar
Suresh Kumar
SK
Gupta
D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001794:Blood Pressure; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D030024:Curcuma / Q000737:chemistry*; D004195:Disease Models, Animal; D006339:Heart Rate; D006652:Histological Techniques; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology
D000975:Antioxidants; D002316:Cardiotonic Agents; D010936:Plant Extracts