Effect of chemotherapy on segmental bone healing enhanced by rhBMP-2.
Segmental bone defects are challenging clinical problems, and current surgical solutions are associated with high complication rates. In oncologic reconstructive surgery, bone healing will occur coincidently with the administration of chemotherapy to treat the underlying disease. Effective methods of graft modification or bone graft alternatives can be of great help clinically. A series of osteoinductive proteins (bone morphogenetic proteins or BMPs) has been described and shown to enhance bone formation in animal models. This study was designed to evaluate the effect of chemotherapy on bone healing enhanced by rhBMP-2. We used a critical-sized bone-defect rabbit model. Histological and radiological analysis showed that chemotherapy affects both the quantity and the quality of the bone enhanced by the addition of rhBMP-2. These results suggest that the effect of chemotherapy on bone formation could be related to inhibition in a specific pathway stimulated by the rhBMP-2.
Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. jose-morcuende@uiowa.edu
Jose A
JA
Morcuende
Pablo
P
Gomez
Jeffrey
J
Stack
George
G
Oji
James
J
Martin
Douglas C
DC
Fredericks
Joseph A
JA
Buckwalter
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000502:physiology*; D001859:Bone Neoplasms / Q000188:drug therapy*; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D002945:Cisplatin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D011817:Rabbits; D016212:Transforming Growth Factor beta
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta; D004317:Doxorubicin; D002945:Cisplatin