Granulocyte colony-stimulating factor induces disease flare in patients with antineutrophil cytoplasmic antibody-associated vasculitis.
Recombinant human granulocyte colony-stimulating factor (rhuG-CSF) is frequently given to patients with leukopenia or neutropenia caused by various underlying diseases. The treatment with rhuG-CSF is apparently safe, although cutaneous vasculitis and flares in patients with autoimmune diseases are described. We describe 2 patients with histologically proven antineutrophil cytoplasmic antibody-associated systemic vasculitis with disease flares after administration of rhuG-CSF, given to improve collection of stem cells prior to autologous stem cell transplantation.
Center for Rheumatology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany. iking-konert@med.uni-duesseldorf.de
Christof
C
Iking-Konert
Benedikt
B
Ostendorf
Mark
M
Foede
Rebecca
R
Fischer-Betz
Gregor
G
Jung
Maria G
MG
Haensch
Matthias
M
Schneider
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000000981:diagnostic imaging / Q000187:drug effects; D013902:Radiography, Thoracic; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D036542:Tomography, Spiral Computed; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000000981:diagnostic imaging / Q000276:immunology / Q000503:physiopathology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor