GARField magnetic resonance profiling of the ingress of model skin-care product ingredients into human skin in vitro.
A preliminary study of the ingress of mineral oil, decanol, and glycerine into samples of human abdominal skin tissue in vitro made using magnetic resonance profiling with a GARField magnet is reported. Two layers, each circa 50 microm thick and attributed to stratum corneum and viable epidermis, are spatially resolved. Clear differences are observed in the magnetic resonance response of these layers arising from the application of the model skin-care product ingredients. In the case of decanol and glycerine, it is suggested that the profiles show evidence for the effects of moisturization, as distinct from hydration. In the case of glycerine, the effective ingress diffusion coefficient is calculated to be 1.3 +/- 0.5 x 10(-9) cm2s(-1).
School of Electronics and Physical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom.
L
L
Backhouse
M
M
Dias
J P
JP
Gorce
J
J
Hadgraft
P J
PJ
McDonald
J W
JW
Wiechers
D004817:Epidermis / Q000187:drug effects / Q000378:metabolism; D005990:Glycerol / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008280:Magnetics / Q000295:instrumentation; D008899:Mineral Oil / Q000008:administration & dosage / Q000493:pharmacokinetics; D008954:Models, Biological; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D017592:Skin Care / Q000379:methods
D008899:Mineral Oil; D005990:Glycerol