Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
A binary complex of dihydropteridine reductase and NADH crystallizes in the space group C2, with a = 222.2, b = 46.5, c = 95.3 A and beta = 101.1 degrees. There are two dimers in the asymmetric unit. The structure was solved by molecular-replacement techniques and refined with 2.6 A data to a crystallographic R factor of 16.8%. Each dimer has twofold non-crystallographic symmetry and the four individual monomers in the asymmetric unit have the same overall molecular conformation.
Su
Y
Y
Department of Chemistry, University of California, San Diego, La Jolla 92093-0317, USA.
Skinner
M M
MM
Xuong
N H
NH
Matthews
D A
DA
Whiteley
J M
JM
Varughese
K I
KI