BCG (Bacille Calmette-Guérin) HspCs (heat-shock protein-peptide complexes) induce T-helper 1 responses and protect against live challenge in a murine aerosol challenge model of pulmonary tuberculosis.
The need for an effective TB (tuberculosis) vaccine remains acute, with tuberculosis still one of the major killers worldwide and 3 million new infections annually. We report here on the immune responses elicited by HspCs (heat-shock protein-peptide complexes) isolated from BCG (Bacille Calmette-Guérin) vaccine. These HspCs elicit both the appropriate cellular and protective immune responses required to merit their further development as TB vaccine candidates.
Colaco
C A L S
CA
ImmunoBiology Limited, Babraham BioIncubator, Babraham, Cambridge CB2 4AT, UK. Camilo.Colaco@immunobiology.co.uk
Bailey
C R
CR
Keeble
J
J
Walker
K B
KB
D000336:Aerosols; D000818:Animals; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000378:metabolism*
D000336:Aerosols; D006360:Heat-Shock Proteins