Preparation and characterization of enrofloxacin/carbopol complex in aqueous solution.
Since the bitter taste of enrofloxacin apparently limit the patient compliance in the oral formulations of the antibacterial agent, the masking of the taste is essential for the improvement of the therapeutic effectiveness. Therefore, this study was carried out to examine the feasibility of taste masking of enrofloxacin by the retardation of its dissolution rate using the formation of complex between the drug and Carbopol. The complexation between Carbopol and enrofloxacin was confirmed by turbidity, UV spectrophotometry, wide angle X-ray diffraction, and differential scanning calorimetry. The enrofloxacin content in the complexes was 34% (Carbo-enrofloxacin complex I) and 57% (Carbo-enrofloxacin complex II) depending on the preparation method. The dissolution rate of enrofloxacin from the complex increased as the pH was reduced. The dissolution rate of enrofloxacin from the Carbo-enrofloxacin complex I was significantly lower than that of the enrofloxacin powder. Therefore, these observations suggest that Carbo-enrofloxacin complex I can be used to mask the taste of enrofloxacin.
College of Pharmacy, Chosun University, Gwangju 501-759, Korea.
Myung-Kwan
MK
Chun
Hoo-Kyun
HK
Choi
D000180:Acrylic Resins; D000890:Anti-Infective Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D019999:Pharmaceutical Solutions; D011145:Polyvinyls / Q000737:chemistry*; D011208:Powders; D015363:Quinolones / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D014867:Water; D014961:X-Ray Diffraction
D000180:Acrylic Resins; D000890:Anti-Infective Agents; D004337:Drug Carriers; D024841:Fluoroquinolones; D019999:Pharmaceutical Solutions; D011145:Polyvinyls; D011208:Powders; D015363:Quinolones; D014867:Water; C006912:carboxypolymethylene; D000077422:Enrofloxacin