Protein kinase C and beyond.
Protein kinase C molecules regulate both positive and negative signal transduction pathways essential for the initiation and homeostasis of immune responses. There are multiple isoforms of protein kinase C that are activated differently by calcium and diacylglycerol, and these are activated mainly by antigen receptors in T cells, B cells and mast cells. Additionally, mammals express several other diacylglycerol binding proteins that are linked to a network of key signal transduction pathways that control lymphocyte biology. Diacylglycerol and protein kinase C regulate a broad range of gene transcription programs but also modulate integrins, chemokine responses and antigen receptors, thereby regulating lymphocyte adhesion, migration, differentiation and proliferation.
School of Life Sciences, Division of Cell Biology & Immunology, University of Dundee, MSI/WTB Complex, Dow Street, Dundee DD1 5EH, UK.
Martin
M
Spitaler
Doreen A
DA
Cantrell
D000818:Animals; D004075:Diglycerides / Q000276:immunology / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000187:drug effects / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D011493:Protein Kinase C / Q000187:drug effects / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*
D004075:Diglycerides; D007527:Isoenzymes; D011493:Protein Kinase C