Null type of glutathione S-transferase M1 polymorphism is associated with early onset pterygium.
OBJECTIVE
To investigate the association of glutathione S-transferase M1 (GSTM1) null genotype with pterygium.


METHODS
One hundred and twenty seven pterygium patients and 102 volunteers without pterygium were enrolled in this study. Polymerase chain reaction based analysis was used to resolve the GSTM1 null and positive genotypes.


RESULTS
There was no significant difference between total pterygium and the control group. When stratified by the age, there was a significantly higher frequency of the GSTM1 null genotype in younger patients. The difference was not significant between patients and controls older than 60 years old.


CONCLUSIONS
These results indicate GSTM1 null genotype is associated with early onset pterygium, but not associated with late onset pterygium.
Department of Ophthalmology, China Medical University Hospital and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Yi-Yu
YY
Tsai
Huei
H
Lee
Sung-Huei
SH
Tseng
Ya-Wen
YW
Cheng
Chang-Hai
CH
Tsai
Yu-Hsiao
YH
Wu
Fuu-Jen
FJ
Tsai
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D004247:DNA / Q000032:analysis; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011625:Pterygium / Q000235:genetics*
D019363:Cytochrome P-450 CYP1A1; D004247:DNA; D005982:Glutathione Transferase; D007527:Isoenzymes