Axon guidance: mice and men need Rig and Robo.
For many growing axons, navigating across the midline of the nervous system is a crucial stage of their development. New studies on mice and humans show that the axon guidance receptor Robo3/Rig1 is indispensable for axons to accomplish this task.
MRC Centre for Developmental Neurobiology, 4th Floor New Hunt's House, King's College, London SE1 1UL, UK. sarah.guthrie@kcl.ac.uk
Sarah
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Guthrie
D000818:Animals; D001369:Axons / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002490:Central Nervous System / Q000196:embryology*; D006801:Humans; D051379:Mice; D009414:Nerve Growth Factors / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*; D009421:Nervous System Malformations / Q000503:physiopathology; D000075388:Netrin-1; D011971:Receptors, Immunologic / Q000378:metabolism / Q000502:physiology*; D025521:Tumor Suppressor Proteins; D000097905:Roundabout Proteins
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D000075388:Netrin-1; D011971:Receptors, Immunologic; D025521:Tumor Suppressor Proteins; D000097905:Roundabout Proteins; C492289:SLIT1 protein, human; C120010:Slit1 protein, mouse