Homocysteine and cardiovascular disease: a 17-year follow-up study in Busselton.
OBJECTIVE
Prospective assessment of serum homocysteine level in relation to risk of coronary heart disease (CHD) and stroke.


METHODS
Case-cohort study with 17 years follow up.


METHODS
Homocysteine was measured from stored serum. Proportional hazards regression models were used to obtain adjusted hazard ratios.


RESULTS
There was no significant overall relationship between homocysteine and cardiovascular disease after controlling for known confounders. For women, removal of creatinine from the multivariate model resulted in a significant relationship.


CONCLUSIONS
These results provide little support for a significant independent relationship between level of homocysteine and risk of CHD or stroke in men and women with no evidence of pre-existing cardiovascular disease.
School of Population Health, University of Western Australia, Crawley, Western Australia.
Colleen M
CM
O'Leary
Matthew W
MW
Knuiman
Mark L
ML
Divitini
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D016022:Case-Control Studies; D015986:Confounding Factors, Epidemiologic; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000097:blood / Q000453:epidemiology
D015415:Biomarkers; D006710:Homocysteine; D003404:Creatinine