IL-5 links adaptive and natural immunity in reducing atherosclerotic disease.
Oxidized LDL induces changes in several facets of the immune system, although the relationships between these facets and their contributions to atherogenesis have yet to be fully elucidated. A report in this issue of the JCI provides a novel demonstration of the adaptive immune system influencing the production of natural antibodies. The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC. Atherosclerotic lesion size in LDL receptor-deficient mice is reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the link between the adaptive and natural immune systems.
Daugherty
Alan
A
Gill Heart Institute, University of Kentucky, Lexington, Kentucky 40536-0200, USA. Alan.Daugherty@uky.edu
Rateri
Debra L
DL
King
Victoria L
VL
D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D001057:Apolipoproteins E / Q000172:deficiency; D001161:Arteriosclerosis / Q000517:prevention & control*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D015848:Interleukin-5 / Q000235:genetics / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000276:immunology; D008315:Malondialdehyde / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D011973:Receptors, LDL / Q000172:deficiency; D018418:Th2 Cells / Q000276:immunology
D001057:Apolipoproteins E; D015848:Interleukin-5; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde