Physical transformation of niclosamide solvates in pharmaceutical suspensions determined by DSC and TG analysis.
This study reports the preparation of four niclosamide solvates and the determination of the stability of the crystal forms in different suspension vehicles by DSC and TG analysis. Thermal analysis showed that the niclosamide solvates were extremely unstable in a PVP-vehicle and rapidly changed to monohydrated crystals. A suspension in propylene glycol was more stable and TG analysis showed that crystal transformation was less rapid. In this vehicle, the crystals transformed to the anhydrate, rather than the monohydrate, since the vehicle was non-aqueous. The TEG-hemisolvate was the most stable in suspension and offered the best possibility of commercial exploitation.
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 71209, USA. devilliers@ulm.edu
M M
MM
de Villiers
M D
MD
Mahlatji
S F
SF
Malan
E C
EC
van Tonder
W
W
Liebenberg
D000465:Algorithms; D000871:Anthelmintics / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D018360:Crystallography, X-Ray; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D004355:Drug Stability; D007700:Kinetics; D009534:Niclosamide / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012996:Solutions; D012997:Solvents; D013535:Suspensions; D013818:Thermogravimetry
D000871:Anthelmintics; D012996:Solutions; D012997:Solvents; D013535:Suspensions; C028914:triethylene glycol; D011092:Polyethylene Glycols; D004126:Dimethylformamide; D009534:Niclosamide; D004121:Dimethyl Sulfoxide