Protective effects of prostaglandin I2 analogues on CPK release in rat's heart-lung preparation.
The effects of prostaglandin I(2) analogues (PGI(2)-a: op-41483 and op-2507) on oxygen toxicity during hyperoxic perfusion were evaluated in an experiment on isolated rat heart lung preparation, with the release of creatine phosphokinase (CPK) in the perfusate blood. There were no significant differences in heart rate and right atrial pressure between PGI(2)-a treated and untreated hearts. The CPK release from the heart with oxygen was significantly higher than that of the air ( P < 0.001). However, the CPK release from the PGI(2)-a treated hearts was significantly less than that from the untreated hearts ( P < 0.05). These results indicate that PGI(2)-a may prevent cell damage which was induced by hyperoxia.
Kashimoto
S
S
Department of Anesthesia, Kohfu City Hospital, Yamanashi, Japan.
Nakamura
T
T
Oguchi
T
T
Kume
M
M
Kumazawa
T
T