Long-term alcohol exposure prior to conception results in lower fetal body weights.
BACKGROUND
It is well known that alcohol consumption during pregnancy can result in lower birth weight babies but many women stop consuming alcohol prior to conception as a part of pregnancy planning. The purpose of this study was to determine whether alcohol consumption prior to conception may also have an effect on fetal development.


METHODS
Male and female C57BL/6J mice at 4, 6, or 8 weeks of age received either a single administration of alcohol (3.0 g/kg) via intragastric gavage (IG) each day for at least 60 days, or an isovolumetric IG administration of sterile water. After 60 treatment days, males and females within each age and treatment group were mated overnight. Females continued to receive daily alcohol treatments until conception. Males continued to receive treatments until all females were successfully mated. At conception, females were isolated and left undisturbed. On embryonic day 14, fetus number, size, and weight was determined.


RESULTS
Maternal food consumption, body weight at conception, and delay to conception onset did not differ between the two treatment groups or among the three age groups. Fetal body weights did not differ among the three age groups. Fetuses from females treated with alcohol had lower body weights compared to those treated with water. Male treatments did not seem to affect fetal body weight.


CONCLUSIONS
Fetal growth and development can be affected by alcohol consumption prior to the time of conception. Alcohol consumption prior to conception is a potential risk factor to fetal outcome and an important consideration for those females planning to have children.
Division of Anatomy, University of Alberta, Edmonton, Alberta, Canada. dlivy@ualberta.ca
Daniel J
DJ
Livy
Susan E
SE
Maier
James R
JR
West
D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D001835:Body Weight; D005260:Female; D020567:Fetal Weight / Q000187:drug effects*; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D008810:Mice, Inbred C57BL; D018812:Paternal Exposure; D047489:Preconception Injuries; D011247:Pregnancy; D012307:Risk Factors; D013997:Time Factors