[Preparation of lymphatic targeting dosage form: pingyangmycin absorbed on activated carbon nanoparticles].
OBJECTIVE
To prepare anticancer nanoparticles for targeting therapy for oral cancer lymph node metastasis.


METHODS
The activated carbon nanoparticles (CH-NP) were prepared for drug carrier. Pingyangmycin (PYM), a high sensitive anticancer drug for oral squamous cell carcinoma, were selected as model drug. The activated carbon nanoparticles and PYM were mixed with saline and shaken 20 minutes so that PYM was absorbed on activated carbon enough, resulting in a new formulation of PYM (PYM-CH-NP). The absorbency of PYM on activated carbon nanoparticles was evaluated.


RESULTS
The diameter distribution for CH-NP ranged form 136 nm, to 540 nm, the average diameter was 176 nm. The proportion of CH-NP to PYM was increased and more absorbency of PYM on activated carbon nanoparticles was achieved.


CONCLUSIONS
The activated carbon nanoparticles has high absorbency of PYM. The new formulation PYM-CH-NP can be used as targeting therapy of cervical lymph node metastasis by peri-cancer submucosal injection.
Dept. of Stomatology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Ming-lei
ML
Sun
Yu-ming
YM
Wen
Chang-mei
CM
Wang
Long-jiang
LJ
Li
Xiao-yi
XY
Wang
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D002244:Carbon / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary; D006801:Humans; D007272:Injections, Intralymphatic; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology*; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology; D053758:Nanoparticles; D009333:Neck
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C025703:bleomycetin; D002244:Carbon