[Baseline clinical features of 483 children and adolescents with primary vesicoureteral reflux: a retrospective study].
OBJECTIVE
To evaluate the clinical/radiological features of patients with primary vesicoureteral reflux (VUR) admitted to a single institution from 1969 to 1999.


METHODS
At admission, after the institution of chemoprophylaxis, patients were investigated by CUM, DMSA, and US. The children were managed with periodical clinical and laboratory evaluations. Analyses were performed with the data obtained at admission.


RESULTS
A total of 483 patients were enrolled in the protocol. There was a predominance of females (70%) and caucasian race (70%). Mean age at VUR diagnosis was 26 months and 92.5% of the patients had urinary infection before admission. A total of 710 refluxing units were analyzed. The distribution of reflux grade was: grade I (49; 7%); II (254; 36%); III (190; 26%); IV (161; 23%) e V (56; 8%). Approximately one half of the units analyzed were from patients presenting renal damage at admission. The distribution of the severity of renal damage was as follows: mild (36%), moderate (34%), and severe (30%). There was a significant risk of severe renal damage for the males (OR = 1.74, 95% CI = 1.2 - 2.5, p = 0.002).


CONCLUSIONS
There was a predominance of VUR among females and most presented a mild or moderate degree. However, there was a high percentage of renal damage at admission and a tendency to greater morbidity for the males.
Silva
José Maria Penido
JM
Unidade de Nefrologia, Hospital das Clínicas, Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG.
Diniz
José Silvério S
JS
Oliveira
Eduardo A
EA
Marino
Viviane S P
VS
Pimenta
Mariana R
MR
Matos
Carolina C
CC
Vieira
Samana B
SB
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000175:diagnosis*