The complete genome sequence of Propionibacterium acnes, a commensal of human skin.
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.
Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Göttingen, Grisebachstrasse 8, 37077 Göttingen, Germany. hbruegg@pasteur.fr
Holger
H
Brüggemann
Anke
A
Henne
Frank
F
Hoster
Heiko
H
Liesegang
Arnim
A
Wiezer
Axel
A
Strittmatter
Sandra
S
Hujer
Peter
P
Dürre
Gerhard
G
Gottschalk
D000152:Acne Vulgaris / Q000276:immunology / Q000382:microbiology; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000737:chemistry / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D019295:Computational Biology; D004734:Energy Metabolism; D004950:Esterases / Q000235:genetics / Q000378:metabolism; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D006867:Hydrolases / Q000235:genetics / Q000378:metabolism; D008049:Lipase / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D010085:Oxidative Phosphorylation; D011425:Propionibacterium acnes / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D017422:Sequence Analysis, DNA; D012867:Skin / Q000382:microbiology*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; D006867:Hydrolases; D004950:Esterases; D008049:Lipase