Very delayed neuronal loss occurs in the glomerular layer of the main olfactory bulb following transient ischemia in gerbils.
Olfactory dysfunction could happen following various insults such as ischemic-hypoxic state. Neurons of the main olfactory bulb (MOB) are resistant to ischemic damage. In the present study, we investigated the ischemia-related changes of neurons and glial cells in the glomerular layer (GL) of the gerbil MOB after transient ischemia. The number of NeuN-immunoreactive neurons became to decrease from 10 days after ischemic insult. Fifteen days after ischemic insult, astrocytes and microglia were increased in number. By 60 days after ischemia, NeuN-immunoreactive neurons were significantly decreased by 42% per glomerulus. At this time period, astrocytes and microglia were pronouncedly increased. This result indicates that neuronal loss must be much delayed in the GL following transient ischemia.
Department of Anatomy, College of Medicine, Hallym University, 1 Okchon-dong, Chunchon 200-702, South Korea.
In Koo
IK
Hwang
Jae Chul
JC
Lee
Jun Hwi
JH
Cho
Ki-Yeon
KY
Yoo
Duk Soo
DS
Kim
Young Sam
YS
Nam
Won-Ki
WK
Kim
In Se
IS
Lee
Tae-Cheon
TC
Kang
Moo Ho
MH
Won
D000818:Animals; D039481:CD11b Antigen / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D016923:Cell Death; D005849:Gerbillinae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009410:Nerve Degeneration; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000473:pathology*; D009830:Olfactory Bulb / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D013997:Time Factors
D039481:CD11b Antigen; D005904:Glial Fibrillary Acidic Protein; D010751:Phosphopyruvate Hydratase