Peroxisome proliferator-activated receptor gamma; Its role in atherosclerosis and restenosis.
Cellular proliferation and migration are fundamental processes that contribute to the injury response in major blood vessels. The resultant pathologies are atherosclerosis and restenosis. As we begin to understand the cellular changes associated with vascular injury, it is critical to determine whether the inhibition of growth and movement of cells in the vasculature could serve as a novel therapeutic strategy to prevent atherosclerosis and restenosis.
Cardiovascular Research Institute, Washington Hospital Center, 110 Irving Street, NW, Suite 4B-1, Washington, DC 20010, USA.
Rajbabu
R
Pakala
Seung-Woon
SW
Rha
Pramod Kumar
PK
Kuchulakanti
Edouard
E
Cheneau
Richard
R
Baffour
Ron
R
Waksman
D000818:Animals; D015415:Biomarkers / Q000097:blood; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000517:prevention & control; D023903:Coronary Restenosis / Q000517:prevention & control*; D023921:Coronary Stenosis / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D047492:Peroxisome Proliferator-Activated Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D015415:Biomarkers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D047492:Peroxisome Proliferator-Activated Receptors