Beta-lactam antibiotic-induced pseudoporphyria.
A case of beta-lactam antibiotic-induced pseudoporphyria is presented. A 24-year-old African American woman with systemic lupus erythematosus and end-stage renal disease on hemodialysis developed tense bullae on her forehead and cheeks after exposure to ampicillin-sulbactam and cefepime. Histologically, the lesions were similar to porphyria cutanea tarda, but without the associated porphyrin abnormalities. The lesions resolved spontaneously on cessation of the antibiotics.
Phung
Thuy L
TL
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. tphung@bidmc.harvard.edu
Pipkin
Clare A
CA
Tahan
Steven R
SR
Chiu
Diane S
DS
D018784:Abdominal Abscess / Q000150:complications / Q000188:drug therapy; D000667:Ampicillin / Q000009:adverse effects*; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D001706:Biopsy; D005184:Fallopian Tube Diseases / Q000150:complications / Q000188:drug therapy; D005260:Female; D005546:Forehead; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008875:Middle Aged; D010049:Ovarian Diseases / Q000150:complications / Q000188:drug therapy; D011537:Pruritus / Q000139:chemically induced; D006435:Renal Dialysis; D012805:Sickle Cell Trait / Q000150:complications; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D013407:Sulbactam / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000150:complications
D000900:Anti-Bacterial Agents; C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam