Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures.
Various studies have shown that brain-derived neurotrophic factor (BDNF) increased neuronal excitability. We tested that BDNF might be involved in the etiology of febrile seizures (FSs). A total of 186 Taiwanese children were divided into two groups: (1) FSs (n = 104); (2) normal control subjects (n = 83). A single base pair polymorphism SNP6265 (Val66Met) at position 196 was analyzed. Our findings suggest that the BDNF polymorphisms were not candidate genetic markers.
Chou
I-Ching
IC
Departments of Pediatrics, China Medical University Hospital, Taichung, Taiwan.
Tsai
Chang-Hai
CH
Lee
Cheng-Chun
CC
Lin
Sheng-Shing
SS
Tsai
Fuu-Jen
FJ
D000483:Alleles; D044466:Asian People / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008715:Methionine; D020641:Polymorphism, Single Nucleotide; D003294:Seizures, Febrile / Q000235:genetics*; D013624:Taiwan; D014633:Valine
D019208:Brain-Derived Neurotrophic Factor; D005819:Genetic Markers; D008715:Methionine; D014633:Valine