[Immunosuppressive activity of exopolysaccharide from Paecilomyces gunnii].
OBJECTIVE
To investigate bioactivities of Paecilomyces gunnii exopolysaccharide (PGEP).


METHODS
The effects of PGEP on mice spleen lymphocytes proliferation, mice peritoneal macrophage (PMphi) phagocytosis and cytotoxin T lymphocytes (CTL) activity were studied by MTT method, neutral red colorimetry, respectively.


RESULTS
In vitro, mice spleen lymphocytes proliferation, mice peritoneal macrophage (PMphi) phagocytosis of neutral red and CTL activity were significant suppressed by PGEP, especially in 10 microg/ml.


CONCLUSIONS
PGEP had the immunosuppressive activities.
Key Lab. of Cell Engineering of Guizhou Province, the Affiliated Hospital of Zunyi Medical College, Zunyi 563003.
Jianhui
J
Xiao
Ning
N
Fang
Yu
Y
Xiao
Ying
Y
Qi
Jinwei
J
Liu
Zongqi
Z
Liang
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010143:Paecilomyces / Q000737:chemistry*; D010587:Phagocytosis / Q000187:drug effects*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects
D007166:Immunosuppressive Agents; D011134:Polysaccharides