A geometric model for evaluating the effects of inter-fraction rectal motion during prostate radiotherapy.
A geometric model is presented which allows calculation of the dosimetric consequences of rectal motion in prostate radiotherapy. Variations in the position of the rectum are measured by repeat CT scanning during the courses of treatment of five patients. Dose distributions are calculated by applying the same conformal treatment plan to each imaged fraction and rectal dose-surface histograms produced. The 2D model allows isotropic expansion and contraction in the plane of each CT slice. By summing the dose to specific volume elements tracked by the model, composite dose distributions are produced that explicitly include measured inter-fraction motion for each patient. These are then used to estimate effective dose-surface histograms (DSHs) for the entire treatment. Results are presented showing the magnitudes of the measured target and rectal motion and showing the effects of this motion on the integral dose to the rectum. The possibility of using such information to calculate normal tissue complication probabilities (NTCP) is demonstrated and discussed.
Department of Medical Physics, The German Cancer Research Centre, Heidelberg, Germany.
Luciana M
LM
Pavel-Mititean
Carl G
CG
Rowbottom
Charlotte L
CL
Hector
Mike
M
Partridge
Thomas
T
Bortfeld
Wolfgang
W
Schlegel
D000465:Algorithms; D006801:Humans; D008297:Male; D008954:Models, Biological; D009068:Movement; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D020266:Radiotherapy, Conformal / Q000379:methods; D012007:Rectum / Q000000981:diagnostic imaging* / Q000503:physiopathology