Effect of defibrillation pulses of different shapes on biomembranes: experimental study.
We studied the effects of high-voltage single, double unipolar, and double bipolar electric pulses of exponential or sine shape on erythrocyte membranes. Either single or double (mono- or bipolar) pulses were used. All pulses electroporated the membranes, and the electroporation threshold did not depend on the pulse shape. Two successive pulses decreased erythrocyte number in a nonadditive way. Similar to defibrillation of the whole heart, the effect of two bipolar pulses on erythrocytes was more pronounced than the effect of two unipolar pulses.
Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow, Russia.
V V
VV
Moroz
M S
MS
Bogushevich
A M
AM
Chernysh
E K
EK
Kozlova
A S
AS
Sharakshane
D004554:Electric Countershock / Q000009:adverse effects* / Q000379:methods; D004594:Electrophysiology; D018274:Electroporation; D004910:Erythrocyte Membrane / Q000502:physiology*; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics