Amino acid composition of Nephrophyt, a new complex plant preparation and its possible role in correction of mercuric chloride-induced acute renal failure in rats.
Amino acid composition of a new Russian nephroprotective drug Nephrophyt (a complex mixture of dry plant extracts) was studied for the first time in order to validate its pharmacological effects in rats with mercuric chloride-induced nephropathy. The concentration of pyrrolidone amino acids and serine in this preparation was extremely high, which is uncommon for plant raw material. These data are in good correlation with pronounced nephroprotective effect and agree with published reports on pharmacological effects of individual amino acids and their metabolites. The prospects of the use of this preparation based on the data on its amino acid composition are discussed.
Markaryan
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AA
I. M. Setchenov Moscow Medical Academy, Moscow. markaria@rol.ru
Alyautdin
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RN
Mondodoev
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AG
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy*; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005260:Female; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D012694:Serine / Q000032:analysis
D000596:Amino Acids; D028321:Plant Preparations; D012694:Serine; D008627:Mercuric Chloride