Myosin assembly: the power of multiubiquitylation.
Ubiquitylation provides a means of targeting substrate proteins for degradation by the proteasome. Novel findings in C. elegans (Hoppe et al., 2004, this issue of Cell) establish that two ubiquitin-ligases team up to multiubiquitylate the myosin chaperone UNC-45, suggesting a novel link between regulated protein degradation and myosin assembly.
Gönczy
Pierre
P
ISREC (Swiss Institute for Experimental Cancer Research), 155, ch. des Boveresses, CH-1066 Epalinges/Lausanne.
D009218:Myosins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D025801:Ubiquitin; D009218:Myosins