APOBEC-mediated editing of viral RNA.
Retroviral DNA can be subjected to cytosine-to-uracil editing through the action of members of the APOBEC family of cytidine deaminases. Here we demonstrate that APOBEC-mediated cytidine deamination of human immunodeficiency virus (HIV) virion RNA can also occur. We speculate that the natural substrates of the APOBEC enzymes may extend to RNA viruses that do not replicate through DNA intermediates. Thus, cytosine-to-uracil editing may contribute to the sequence diversification of many viruses.
Bishop
Kate N
KN
Department of Infectious Diseases, Guy's, King's and St. Thomas' School of Medicine, King's College London, London, SE1 9RT, UK.
Holmes
Rebecca K
RK
Sheehy
Ann M
AM
Malim
Michael H
MH
D000071479:APOBEC-1 Deaminase; D000071480:APOBEC-3G Deaminase; D000818:Animals; D002460:Cell Line; D003564:Cytidine Deaminase / Q000378:metabolism*; D018076:DNA, Complementary / Q000378:metabolism; D015754:Genes, nef; D014644:Genetic Variation; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009700:Nucleoside Deaminases; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000378:metabolism*; D017393:RNA Editing; D012367:RNA, Viral / Q000378:metabolism*; D051381:Rats; D012097:Repressor Proteins; D014162:Transfection
D018076:DNA, Complementary; D011506:Proteins; D012367:RNA, Viral; D012097:Repressor Proteins; D009700:Nucleoside Deaminases; D000071479:APOBEC-1 Deaminase; C000605089:APOBEC1 protein, human; C000605091:Apobec1 protein, rat; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase