Mechanical characterization of native and tissue-engineered cartilage.
Cartilage functions as a low-friction, wear-resistant, load-bearing tissue. During a normal gait cycle, one cartilage surface rolls and slides against another, all the while being loaded and unloaded. The durability of the tissue also makes for an impressive material to study. However, when cartilage is damaged or diseased, the tissue has little capacity to repair itself. The goal of cell-based repair strategies to replace damaged or diseased tissue requires that the functional biomechanical properties of normal (developing or mature), diseased, and repair cartilage be restored. This chapter addresses some of the major methods used to assess the biomechanical properties of native and tissue-engineered cartilage. First, the traditional methods of testing by compression, tension, shear, and indentation are reviewed. Next, additional methods to evaluate interfacial mechanics and lubrication are described. Thus, a variety of mechanical tests may be used to assess functional properties for normal, diseased, and tissue-engineered cartilage.
Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA, USA.
Albert C
AC
Chen
Stephen M
SM
Klisch
Won C
WC
Bae
Michele M
MM
Temple
Kevin B
KB
McGowan
Kenneth R
KR
Gratz
Barbara L
BL
Schumacher
Robert L
RL
Sah
D000818:Animals; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000737:chemistry* / Q000378:metabolism; D002417:Cattle; D017276:Friction; D006801:Humans; D013314:Stress, Mechanical; D000267:Tissue Adhesions; D023822:Tissue Engineering