Refined three-dimensional structure of cat-muscle (M1) pyruvate kinase at a resolution of 2.6 A.
The three-dimensional structure of cat-muscle pyoruvate kinase has been refined at a resolution of 2.6 A. The details of the structure permit interpretation of the original heavy-atom studies and give insight into the importance of conserved residues in pyruvate kinases and the allosteric behaviour of the enzyme. There are a small number of essential residues which determine the relative orientations of domains and the precise nature of intersubunit contacts. Arginine residues are particularly important.
Allen
S C
SC
Department of Biochemistry and Molecular Recognition Centre, School of Medical Sciences, University of Bristol.
Muirhead
H
H