Intranuclear trafficking: organization and assembly of regulatory machinery for combinatorial biological control.
The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA.
Sayyed K
SK
Zaidi
Daniel W
DW
Young
Je-Yong
JY
Choi
Jitesh
J
Pratap
Amjad
A
Javed
Martin
M
Montecino
Janet L
JL
Stein
Jane B
JB
Lian
Andre J
AJ
van Wijnen
Gary S
GS
Stein
D002467:Cell Nucleus / Q000235:genetics / Q000502:physiology; D002468:Cell Physiological Phenomena; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015870:Gene Expression; D006706:Homeostasis; D008954:Models, Biological; D011506:Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
D011506:Proteins; D004247:DNA