A novel antifungal pyrrole derivative from Datura metel leaves.
Phytochemical investigation of the leaves of Datura metel Linn. led to the isolation of a new pyrrole derivative 1 which was characterised as 2beta-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1'-methylethyl pentanoate on the basis of spectral data analyses and chemical reactions. Compound 1 was endowed with antifungal activity and its MIC was found to be 87.5 microg/ml. Two proteins having molecular weights of 42 and 58 kD of Aspergillus fumigatus are potential targets for compound 1.
Institute of Genomics and Integrative Biology (CSIR), Delhi University Campus, Delhi, India.
R
R
Dabur
M
M
Ali
H
H
Singh
J
J
Gupta
G L
GL
Sharma
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D032302:Datura / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D005656:Fungal Proteins / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014631:Valerates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
C488953:2beta-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1'-methylethyl pentanoate; D000935:Antifungal Agents; D005656:Fungal Proteins; D007202:Indicators and Reagents; D010936:Plant Extracts; D011758:Pyrroles; D012997:Solvents; D014631:Valerates