Subependymal giant cell astrocytoma with cranial and spinal metastases in a patient with tuberous sclerosis. Case report.
This 17-year-old male patient with tuberous sclerosis developed increased headaches and lethargy. Magnetic resonance imaging of the brain revealed increased ventricle size and increased size of a subependymal giant cell astrocytoma at the foramen of Monro, as well as spinal cord metastases of giant cell tumors. Decompressive surgery of the foramen of Monro lesion resulted in temporary resolution of the hydrocephalus. Increased Ki-67 labeling of tumor as well as rare spinal enhancement both possibly indicated malignant features for this entity.
Department of Pathology, Division of Neurosurgery, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA. Telfeian@email.chop.edu
Albert E
AE
Telfeian
Alex
A
Judkins
Donald
D
Younkin
Avrum N
AN
Pollock
Peter
P
Crino
D000293:Adolescent; D001254:Astrocytoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D019299:Decompression, Surgical; D017809:Fatal Outcome; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D013120:Spinal Cord Neoplasms / Q000556:secondary*; D014402:Tuberous Sclerosis / Q000150:complications*