[Spectrum of cytokines produced by blood leukocytes in infection of herpes simplex virus, type 1].
Three types of reaction of human blood leucocytes to herpes simplex virus 1 (HSV-1) were detected. The first reaction type, i.e. production of IFN-alpha, IFN-gamma, IL-1beta, IL-6 and TNFalpha but not of IL-2 or IL-4, denotes the primary body reaction to an infectious agent. The second reaction type is related with infection of activated HSV-1 leucocytes and is accompanied by an inhibited production of IFN-gamma, IL-6 and IL-8, which is targeted at suppressing the antivirus cell mechanisms. The third reaction type is associated with production of IFN-alpha, IFN-gamma, IL-beta, IL-6 and TNFalpha by blood leucocytes affected by HSV-1-infected leucocytes.
Shcheglovitova
O N
ON
Maksianina
E V
EV
D000818:Animals; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D018920:Coculture Techniques; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis*; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D007372:Interferons / Q000032:analysis / Q000096:biosynthesis; D007378:Interleukins / Q000032:analysis / Q000096:biosynthesis; D007962:Leukocytes / Q000276:immunology* / Q000821:virology; D008213:Lymphocyte Activation; D013997:Time Factors; D014709:Vero Cells
D016207:Cytokines; D007378:Interleukins; D007372:Interferons