Generation of the cortical area map; emx2 strikes back.
The recent identification of molecular cues involved in the generation of the cortical area map, such as the patterning molecule FGF8 and transcription factors such as Emx2, represents an important breakthrough. In this issue of Neuron, Hamasaki et al. use a genetic approach to explore how these signals interact and propose that Emx2 plays a direct, largely FGF8-independent role in the control of the relative size and position that each area occupies within the cortex.
Neuroscience Center, Department of Pharmacology, University of North Carolina, 105 Mason Farm Road, NRB 8109C, Chapel Hill, NC 27599, USA.
Franck
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Polleux
D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D014157:Transcription Factors; D000099260:Empty Spiracles Homeobox Proteins
D018398:Homeodomain Proteins; D014157:Transcription Factors; D000099260:Empty Spiracles Homeobox Proteins