Associations between disease risk and eight polymorphisms adopted for genotype announcements at Nagoya University Hospital.
Genetic polymorphisms have the potential to predict disease susceptibility. This may be especially useful among individuals with a high-risk lifestyle, so that the genotyping could be adopted for disease prevention through modifications toward a lower-risk lifestyle. We started a program of free genotype announcements in a polymorphism study among health checkup examinees at the Nagoya University Hospital on June 9, 2003. Since such announcements remain controversial for fear of unexpected harmful effects and counseling system, the accumulated evidence on the association between disease risk and genotypes announcements in our study was reviewed in this article. The genotypes used were those of alcohol dehydrogenase 2 (ADH2) Arg47His, aldelhyde dehydlrogenase 2 (ALDH2) Glu487Lys, NAD(P)H: quinone oxidoreductase (NQO1) C609T, glutathlione S transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1), interleukin-1B (IL-1B) C-31T, and tumor necrosis factor A (TNF-A) T-1031C, angiotensin converting enzyme (ACE) Ins/Del. Since showed a potential for widespread use in health checkups, the information on the above polymorphisms seems worth documenting. Although there have been no complaints from the participants to date, careful treatments are requested.
Nishio
Kazuko
K
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan.
Nakamura
Sakurako
S
Sekido
Yoshitaka
Y
Niwa
Toshimitsu
T
Hamajima
Nobuyuki
N
D000426:Alcohol Dehydrogenase / Q000235:genetics; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D007564:Japan; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D010808:Physical Examination; D011110:Polymorphism, Genetic; D011808:Quinone Reductases / Q000235:genetics; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D005982:Glutathione Transferase; D007375:Interleukin-1; D016660:NAD(P)H Dehydrogenase (Quinone); D007703:Peptidyl-Dipeptidase A; D011808:Quinone Reductases; D014409:Tumor Necrosis Factor-alpha; C096127:ALDH2 protein, human; C041831:NADH dehydrogenase (quinone); C447479:NQO1 protein, human; C413545:glutathione S-transferase T1