Interferon-gamma and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children.
A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-gamma and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-gamma, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.
Abzug
Mark J
MJ
University of Colorado School of Medicine and The Children's Hospital (Pediatric Infectious Diseases, Department of Pediatrics), Denver, CO 80218, USA. abzug.mark@tchden.org
Walsh
Thomas J
TJ
D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D025141:Drug Resistance, Fungal; D004359:Drug Therapy, Combination; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D009089:Mucor / Q000472:pathogenicity; D009091:Mucormycosis / Q000188:drug therapy* / Q000473:pathology; D008271:Mycetoma / Q000188:drug therapy* / Q000473:pathology; D021681:Scedosporium / Q000472:pathogenicity; D016896:Treatment Outcome
D000998:Antiviral Agents; D016179:Granulocyte Colony-Stimulating Factor; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor