Glycosylation reaction of unprotected sugars with hydroxyalkylthymine.
Under mild conditions (Lewis acid/solvent/room temperature), the reaction of unprotected glucose, deoxyribose or xylose with hydroxylalkylthymine gives selectively nucleoside analogs with a spacer arm between sugar and base moiety. Experimental conditions (Lewis acid, solvent) for this new strategy leading to nucleoside analogs synthesis are discussed.
Zerrouki
Rachida
R
Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Université de Limoges, Limoges, France.
Billard
Luc
L
Granet
Robert
R
Krausz
Pierre
P
D002241:Carbohydrates / Q000737:chemistry*; D006031:Glycosylation; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry*
D002241:Carbohydrates; D011741:Pyrimidine Nucleosides; D013941:Thymine