[Contribution of D2 dopamine receptors of the rat dorsolateral caudate nucleus to immunomodulation].
The analysis of the immune response changes in Wistar rats under activation or blockade of D2 DA receptors has shown that electrolytic lesion of the dorsolateral caudate nucleus characterized by a high density of D2 DA receptors resulted in a decrease of the immune response to SRBC. At the same time, in rats with similar lesion stimulation of the immune reactions caused by a selective D2 agonist guinpirol (1.0 mg/kg) did not develop completely. Administration of haloperidol (2.0 mg/kg), the immune-inhibitory effect of which is associated with increasing serotoninergic system activity, to rats with impaired dorso-lateral caudate nucleus did not produce more expressed immunosuppression. However, the level of the immune response in sham-operated rats receiving haloperidol was significantly lower than that of animal with the destructed nucleus caudatus. Considering that qunmpirol-induced immunostimulation is related to the selective activation of the DA-ergic brain system, it is concluded that D2 DA receptors of the nucleus caudatus are involved in the mechanisms of immunostimulation, although D2 DA receptors of other brain structures may also impact this process.
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D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D065127:Dopamine D2 Receptor Antagonists; D004912:Erythrocytes / Q000276:immunology; D006220:Haloperidol / Q000494:pharmacology; D007114:Immunization / Q000379:methods; D008297:Male; D015213:Neuroimmunomodulation; D019257:Quinpirole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000502:physiology*; D012756:Sheep
D000276:Adjuvants, Immunologic; D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D006220:Haloperidol