Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides.
The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.
Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy. anconacmi@interfree.it
Andrea
A
Giacometti
Oscar
O
Cirioni
Roberto
R
Ghiselli
Fiorenza
F
Orlando
Giuseppina
G
D'Amato
Wojciech
W
Kamysz
Federico
F
Mocchegiani
Valerio
V
Sisti
Carmela
C
Silvestri
Jerzy
J
Łukasiak
Marco
M
Rocchi
Vittorio
V
Saba
Giorgio
G
Scalise
D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides; D001807:Blood Vessel Prosthesis; D015169:Colony Count, Microbial; D024881:Drug Resistance, Bacterial; D004357:Drug Synergism; D006020:Glycopeptides / Q000494:pharmacology*; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000008:administration & dosage / Q000627:therapeutic use*; D019999:Pharmaceutical Solutions; D011093:Polyethylene Terephthalates; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D011506:Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D013212:Staphylococcus epidermidis
D000081:Acetamides; D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D006020:Glycopeptides; D023303:Oxazolidinones; D019999:Pharmaceutical Solutions; D011093:Polyethylene Terephthalates; D011506:Proteins; C104501:temporin; D000069349:Linezolid