Development of a varicella virus vaccine stabilizer containing no animal-derived component.
Various stabilizers containing no animal-derived components were assessed for their efficacy in stabilizing live attenuated varicella virus under various storage temperatures. Stabilizers containing carrageenan, soy protein hydrolysates, or sucrose had a satisfactory performance to maintain infectivity of the cell-free virus when compared to control stabilizer containing animal-derived gelatin/gelatin hydrolysate.
College of Life and Environmental Sciences, Korea University, Anam-dong 5-1, Sungbuk-gu, Seoul 136-701.
Bok-Hwan
BH
Chun
Yong Kwon
YK
Lee
Byung Cheon
BC
Lee
Namhyun
N
Chung
D000818:Animals; D018929:Cell Culture Techniques; D002460:Cell Line; D002474:Cell-Free System; D019433:Chickenpox Vaccine / Q000096:biosynthesis* / Q000737:chemistry*; D004355:Drug Stability; D005347:Fibroblasts / Q000821:virology*; D005780:Gelatin / Q000737:chemistry / Q000494:pharmacology; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D010940:Plant Proteins / Q000737:chemistry / Q000494:pharmacology*
D019433:Chickenpox Vaccine; D010940:Plant Proteins; D005780:Gelatin