Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation.
Insulin-like growth factor 1 (IGF-1) has been shown to rescue the aging-related or inactivity-induced loss of muscle mass through the activation of satellite cells. However, the signalling pathways and the mechanism by which IGF-1 affects satellite cells have not been not completely identified. The purpose of the present review is to provide current understanding of the cellular and molecular events underlying IGF-1 induced proliferation of satellite cells.
Machida
Shuichi
S
Department of Biomedical Sciences, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA.
Booth
Frank W
FW
D000375:Aging / Q000502:physiology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology / Q000502:physiology*; D018482:Muscle, Skeletal / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D032496:Satellite Cells, Skeletal Muscle / Q000187:drug effects / Q000502:physiology*
D007334:Insulin-Like Growth Factor I