Unusual muscle disease in HIV infected patients.
Two patients presented with proximal muscle weakness, a normal or minor elevation of creatine phosphokinase (CPK) and normal findings on electromyography. Muscle biopsy in one patient revealed CD8+ polymyositis, and in the other showed ddI induced myopathy. These cases illustrate the importance of muscle biopsy in identifying the underlying pathology in HIV infected patients with muscle weakness and little or no abnormality in laboratory investigations.
Patrick Manson Unit, University College London Hospitals, London WC1E 6AU, UK.
S
S
Roedling
D
D
Pearl
H
H
Manji
M G
MG
Hanna
J L
JL
Holton
R F
RF
Miller
D019380:Anti-HIV Agents / Q000009:adverse effects; D001706:Biopsy; D018414:CD8-Positive T-Lymphocytes; D003402:Creatine Kinase / Q000378:metabolism; D003937:Diagnosis, Differential; D016049:Didanosine / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D008218:Lymphocytosis / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000201:enzymology / Q000473:pathology* / Q000821:virology; D018482:Muscle, Skeletal / Q000473:pathology*; D017285:Polymyositis / Q000150:complications / Q000175:diagnosis
D019380:Anti-HIV Agents; D003402:Creatine Kinase; D016049:Didanosine