Respiratory distress after intrathecal baclofen withdrawal.
We present the case of a 19-yr-old woman with a history of generalized dystonia who developed sudden onset of adductor spasms of the vocal cords and increased dystonia after the interruption or intrathecal baclofen therapy. Her symptoms resolved after intrathecal baclofen was restored. In patients with dystonia receiving intrathecal baclofen therapy, the onset of dyspnea associated with increased muscle tone should prompt the investigation of baclofen withdrawal.
Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Juan
J
Santiago-Palma
E Daniela
ED
Hord
Ricardo
R
Vallejo
Jason
J
Trella
Shihab U
SU
Ahmed
D000328:Adult; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects*; D003422:Critical Care; D004417:Dyspnea / Q000150:complications; D004421:Dystonia / Q000150:complications; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007278:Injections, Spinal; D007826:Laryngismus / Q000503:physiopathology; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000009:adverse effects*; D009129:Muscle Tonus / Q000187:drug effects; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000503:physiopathology; D012135:Respiratory Sounds / Q000503:physiopathology; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D014827:Vocal Cords / Q000503:physiopathology
D009125:Muscle Relaxants, Central; D001418:Baclofen