Local mechanisms underlying the regulatory effect of Kropanol on hemopoiesis during paradoxical sleep deprivation.
We studied the effect of Kropanol on local regulatory mechanisms of hemopoiesis during paradoxical sleep deprivation. The regulatory effect of Kropanol on granulomonocytopoiesis was determined by increased binding capacity of stromal cells in relation to granulocyte-macrophage precursors and increased formation of mixed hemopoietic islets leading to accelerated maturation of granulocyte-macrophage precursors and hyperplasia of the granulomonocytic hemopoietic stem. Stimulation of erythropoiesis with Kropanol was associated with increased formation of erythroid hemopoietic islets, accelerated differentiation of erythroid precursors, and high content of erythroid cells in the bone marrow. Kropanol increased proliferative activity of erythroid precursors. Stimulation of these processes depended on enhanced production of short-distance humoral regulators of erythro- and granulomonocytopoiesis.
Provalova
N V
NV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
Skurikhin
E G
EG
Pershina
O V
OV
Minakova
M Yu
MY
Suslov
N I
NI
Dygai
A M
AM
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D038042:Myelopoiesis / Q000187:drug effects; D012892:Sleep Deprivation / Q000188:drug therapy / Q000473:pathology*
D001685:Biological Factors; C404022:pantohematogen