Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis.
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.
Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de la Habana, Cuba. monzote@ipk.sld.cu
Lianet
L
Monzote Fidalgo
Ana Margarita
AM
Montalvo Alvarez
Lisset Fonseca
LF
Geigel
Rolando
R
Pérez Pineiro
Margarita
M
Suárez Navarro
Hortensia
H
Rodríguez Cabrera
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007892:Leishmania braziliensis / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D021261:Parasitic Sensitivity Tests; D013829:Thiadiazines / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D013829:Thiadiazines