Crystallographic and thermodynamic comparison of structurally diverse molecules binding to streptavidin.
Crystallographic structures and thermodynamic binding parameters are compared for three structural classes of streptavidin ligand including d-biotin, 2-[(4'-hydroxyphenyl)-azo] benzoate and the peptide NH(2)-Phe-Ser-His-Pro-Gln-Asn-Thr-COOH. Descriptions of these structural and thermodynamic observations emphasize the diversity of potential strategies for improving ligand affinity.
The DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0228, USA.
P C
PC
Weber
M W
MW
Pantoliano
F R
FR
Salemme