Treatment of eosinophilic meningitis with a combination of albendazole and corticosteroid.
To study the efficacy of the combination of albendazole and prednisolone for the treatment of eosinophilic meningitis, we conducted a pilot study among Thai patients with eosinophilic meningitis. Patients were given a 2-week course of prednisolone, 60 mg/day and albendazole, 15 mg/kg/ day. The primary observation parameter was the number of patients who still had headache after the 2-week course of treatment. Twenty-six patients were enrolled in the study. There were 3 (11.5%) patients who still had headache after the 2-week course of treatment and the median length of time until complete disappearance of headache was 4 days. Serious side effects were not detected. Treatment for 2 weeks with the combination regimen of albendazole and prednisolone is safe and effective for the treatment of eosinophilic meningitis.
Chotmongkol
Verajit
V
Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Wongjitrat
Chatchawan
C
Sawadpanit
Kookwan
K
Sawanyawisuth
Kittisak
K
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D015766:Albendazole / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D013785:Thailand; D016896:Treatment Outcome
D011239:Prednisolone; D015766:Albendazole