Lupus arthropathy: historical evolution from deforming arthritis to rhupus.
Systemic lupus erythematosus is an autoimmune and inflammatory disease with multiple clinical manifestations, including arthropathy. The clinical presentation of articular involvement is variable, ranging from arthralgia without erosions or deformity to an erosive arthropathy and severe functional disability. A subset of patients with this articular involvement have Jaccoud's arthropathy, and others have an arthropathy with clinical findings similar to rheumatoid arthritis that has been called "rhupus." In this paper we review the historical evolution of concepts of lupus arthropathy, from deforming arthritis to rhupus, and conclude that rhupus is not a combination of rheumatoid arthritis and lupus. Instead, rhupus arthropathy should be regarded as a variant of the arthropathy of systemic lupus erythematosus.
Department of Internal Medicine, Rheumatology Unit, Universidad Nacional de Colombia, Bogota, Colombia.
Andrés
A
Fernández
Gerardo
G
Quintana
Eric L
EL
Matteson
José Félix
JF
Restrepo
Federico
F
Rondón
Alvaro
A
Sánchez
Antonio
A
Iglesias
D001168:Arthritis / Q000209:etiology / Q000266:history*; D018450:Disease Progression; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000266:history*