The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research.
During recent years, a clear association between complicated courses of ulcerative colitis and the presence of cytomegalovirus (CMV) has been established. The exact pathogenic role of CMV in these patients remains unclear despite a great number of published reports. Therefore, we undertook a systematic review to appraise critically all available evidence in the literature on the role of CMV during inflammatory bowel disease. We identified and analyzed more than 30 case reports and 9 case series. Based on these results, we propose a model for viral replication during inflammation and provide recommendations for future research.
Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands. d.w.hommes@amc.uva.nl
Daniel W
DW
Hommes
Gerben
G
Sterringa
Sander J H
SJ
van Deventer
Guido N J
GN
Tytgat
Jan
J
Weel
D003093:Colitis, Ulcerative / Q000473:pathology / Q000821:virology*; D003106:Colon / Q000473:pathology / Q000821:virology; D003424:Crohn Disease / Q000473:pathology / Q000821:virology*; D003587:Cytomegalovirus / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000150:complications*; D019317:Evidence-Based Medicine; D006801:Humans