Increased bone marrow angiogenesis in children with severe chronic neutropenia treated with granulocyte colony-stimulating factor.
Severe chronic neutropenia (SCN) is a heterogeneous group of conditions characterized by chronically low neutrophil counts and recurrent infections. Granulocyte colony-stimulating factor (G-CSF) is the mainstay of treatment, and evidence exists that G-CSF may promote angiogenesis. To evaluate the effects of G-CSF on angiogenesis in children with SCN, the authors assessed microvessel density in bone marrow biopsies from nine children with SCN before starting G-CSF treatment and while receiving G-CSF. In all patients, microvessel density was greater in the on-treatment biopsy. Increased angiogenesis may result from a direct effect of G-CSF on endothelial cells or may be an indirect effect from increased neutrophils.
Cotter
Melanie
M
Department of Hematology, Children's University Hospital, Temple Street, Dublin, Ireland. melanie.cotter@tsch.ie
Gulmann
Christian
C
Jeffers
Michael
M
Smith
Owen P
OP
D001853:Bone Marrow / Q000098:blood supply* / Q000473:pathology; D002648:Child; D002908:Chronic Disease; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000209:etiology*; D009503:Neutropenia / Q000628:therapy*
D016179:Granulocyte Colony-Stimulating Factor