Animal model for the pathogenesis of reactive amyloidosis.
The pathogenesis of amyloidosis is not well understood. Here, Zafer Ali-Khan, Weihua Li and Sic L. Chan present a metazoan parasite mouse model of reactive amyloidosis, review the relationship between chronic inflammation and multiorgan AA amyloidosis and postulate how ubiquitin might function in the processing of serum amyloid A and in AA amyloid formation in the endosomes-lysosomes of activated murine reticuloendothetial cells.
Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, Canada. AD13@MUISICA.MCGILL.CA
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