Network integration of the adrenergic system in cardiac hypertrophy.
Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered alpha and beta adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure.
Departments of Medicine, Cell Biology and Molecular Genetics, Duke University Medical Center, DUMC 3104 226 CARL Building, Research Drive, Durham, NC 27710, USA.
Liza
L
Barki-Harrington
Cinzia
C
Perrino
Howard A
HA
Rockman
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D011941:Receptors, Adrenergic; D019869:Phosphatidylinositol 3-Kinases; D019204:GTP-Binding Proteins