Immunohistochemical profile of intravenous leiomyomatosis.
To determine the immunohistochemical staining profile of intravenous leiomyomatosis (IVL), we analysed six IVLs and 12 ordinary leiomyomas (LM) for immunoreactivity with a panel of 11 antibodies. All IVLs and LMs reacted with antibodies to alpha-smooth muscle actin (alphasm), h caldesmon, vimentin and progesterone receptor (PR). Five of six IVLs and all LMs reacted with desmin. All IVLs were negative for CD-10. Only one LM exhibited focal CD-10 positivity. Three of six IVLs and nine of 12 LMs showed estrogen receptor expression. All IVLs and LMs showed immunnegativity with MIB-1 and inhibin. There were not any significant differences between immunoreactivity patterns of IVL and LM for asm, desmin, h caldesmon, CD-10, MIB-1 and PR. We conclude that, although they appear to be useful markers in differentiating IVL from ESS and LMS, a larger study also including ESS and LMS would be necessary to confirm their validity.
Department of Pathology, Zeynep Kamil Maternity Hospital, Istanbul, Turkey.
G
G
Kir
H
H
Cetiner
A
A
Gurbuz
S
S
Eren
D000328:Adult; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012494:Sampling Studies; D018203:Sarcoma, Endometrial Stromal / Q000473:pathology*; D012680:Sensitivity and Specificity; D014594:Uterine Neoplasms / Q000473:pathology*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone