Aspirin and indomethacin for the prevention of experimental port-site metastases.
BACKGROUND
Nonsteroidal antiinflammatory drugs have been shown to have antitumor and chemopreventative effects. We investigated the potential of these drugs to inhibit port-site and intraperitoneal metastases.


METHODS
The antiproliferative effect of aspirin and indomethacin on tumor cells was measured in vitro and in vivo. The in vivo experiments used DA rats to measure the effects of aspirin and indomethacin on the development of port-site metastases and the proliferation of intraperitoneal tumor cells after laparoscopy.


RESULTS
In vitro, aspirin and indomethacin had an antiproliferative effect on tumor cells, inhibiting cell division and killing cells in a concentration and time-dependent manner. Orally administered aspirin and indomethacin, at the maximum tolerated dose, did not reduce the rate of intraperitoneal tumor cell division and had no effect on peritoneal metastases, or the number or size of port-site metastases.


CONCLUSIONS
Despite promising in vitro studies, this study does not suggest there will be any clinical therapeutic value associated the use of aspirin or indomethacin for the prevention of the spread of tumor following the spillage of cells into the peritoneal cavity at laparoscopic surgery.
Department of Digestive and General Surgery, Shimane Medical University, 693-8501, Izumo, Japan.
S
S
Kinugasa
E
E
Smith
P A
PA
Drew
D I
DI
Watson
G G
GG
Jamieson
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D049109:Cell Proliferation / Q000187:drug effects; D007213:Indomethacin / Q000008:administration & dosage*; D010535:Laparoscopy / Q000009:adverse effects; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control* / Q000556:secondary; D011292:Premedication; D011677:Punctures / Q000009:adverse effects; D011897:Random Allocation; D051381:Rats; D020303:Rats, Inbred Dahl; D014407:Tumor Cells, Cultured
D001241:Aspirin; D007213:Indomethacin