Biology of LPA in health and disease.
The functions of lysophosphatidic acid (LPA) can be broadly divided into two classes: (1) physiological and (2) pathological roles. The role of LPA in embryonic development can be seen as early as oocyte formation. It continues in postnatal homeostasis, through its ability to impart a level of protection from both stress and local injury, by regulating cellular proliferation, apoptosis, and the reorganization of cytoskeletal fibers. LPA may function as a double-edged sword. While it helps maintain homeostasis against stress and insult, it may also augment the development and spread of pathological processes, including cancers.
Sengupta
Saubhik
S
Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Wang
Zeneng
Z
Tipps
Russell
R
Xu
Yan
Y
D001943:Breast Neoplasms / Q000378:metabolism; D002320:Cardiovascular Physiological Phenomena; D005260:Female; D041981:Gastrointestinal Tract / Q000502:physiology; D005835:Genitalia / Q000502:physiology; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D008297:Male; D009424:Nervous System Physiological Phenomena; D011471:Prostatic Neoplasms / Q000378:metabolism
D008246:Lysophospholipids; C032881:lysophosphatidic acid