Comparison of aortic dissection in patients with and without Marfan's syndrome (results from the International Registry of Aortic Dissection).
Among 1,049 patients diagnosed with aortic dissection in a multinational registry, patients with Marfan's syndrome were typically younger and had unique presentations. Despite their younger age at presentation, patients with Marfan's syndrome and aortic dissection had a high mortality rate, similar to patients without Marfan's syndrome, an older patient cohort. Our data support the importance of aneurysm surveillance and prophylactic surgical intervention for patients with Marfan's syndrome to potentially reduce the risk of mortality.
Thoracic Aorta Center and Cardiology Division, Massachusetts General Hospital, Boston, 02114, USA. jjanuzzi@partners.org
James L
JL
Januzzi
Firas
F
Marayati
Rajendra H
RH
Mehta
Jeanna V
JV
Cooper
Patrick T
PT
O'Gara
Udo
U
Sechtem
Eduardo
E
Bossone
Arturo
A
Evangelista
Jae K
JK
Oh
Christoph A
CA
Nienaber
Kim A
KA
Eagle
Eric M
EM
Isselbacher
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000784:Aortic Dissection / Q000175:diagnosis / Q000453:epidemiology*; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007391:International Cooperation; D008297:Male; D008382:Marfan Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D011336:Probability; D012016:Reference Values; D012042:Registries; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis