In vitro activities of ravuconazole and four other antifungal agents against fluconazole-resistant or -susceptible clinical yeast isolates.
The activities of ravuconazole and four other antifungal agents were tested against a collection of 1,796 clinical yeast isolates, including fluconazole-susceptible and -resistant strains. Ravuconazole was active against the majority of fluconazole-resistant isolates; but for 102 of 562 (18%) resistant isolates, mainly Candida tropicalis, Candida glabrata, and Cryptococcus neoformans, ravuconazole MICs were > or =1 microg/ml.
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain. mcuenca-estrella@isciii.es
Manuel
M
Cuenca-Estrella
Alicia
A
Gomez-Lopez
Emilia
E
Mellado
Guillermo
G
Garcia-Effron
Juan L
JL
Rodriguez-Tudela
D000935:Antifungal Agents / Q000494:pharmacology*; D002177:Candidiasis / Q000382:microbiology; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects*
D000935:Antifungal Agents; D013844:Thiazoles; D014230:Triazoles; D015725:Fluconazole; C104066:ER 30346