Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases.
Although intractable epilepsy associated with hypothalamic hamartoma (HH) can be controlled by microsurgical resection of the lesion, excision of deep-seated lesions is often associated with morbidity and mortality. Endoscopic disconnection is less invasive and seems to be well suited for this indication. The authors discuss the role of endoscopic-assisted surgery in the management of HH-induced seizures. Four patients with HH-related intractable gelastic seizure underwent endoscopic disconnection surgery. Postoperatively, all patients exhibited improvement. Two patients became seizure free immediately after endoscopic disconnection surgery, one patient with a widespread seizure focus involving the motor strip continued to experience rare complex partial seizures but gelastic seizures ceased, and one experienced a reduced frequency of seizures but persistence of some generalized seizures. Three patients suffered postoperative disconnection-like syndrome, which continued 3 to 7 days and spontaneously disappeared. The authors advocate the endoscopic disconnection surgery as a safe and effective treatment for HH-related epilepsy by blocking the spread of epileptic discharges from the lesion.
Department of Neurosurgery and Neurology, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Joong-Uhn
JU
Choi
Kook-Hee
KH
Yang
Tae-Gon
TG
Kim
Jong Hee
JH
Chang
Jin Woo
JW
Chang
Byung-In
BI
Lee
Dong-Seok
DS
Kim
D002648:Child; D004569:Electroencephalography; D004724:Endoscopy; D004828:Epilepsies, Partial / Q000209:etiology / Q000601:surgery*; D005260:Female; D006222:Hamartoma / Q000150:complications / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications / Q000601:surgery*; D007031:Hypothalamus / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon