Milestones of neuronal development in the adult hippocampus.
Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.
VolkswagenStiftung Research Group, Department of Experimental Neurology, Charité University Medicine Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany. gerd.kempermann@mdc-berlin.de
Gerd
G
Kempermann
Sebastian
S
Jessberger
Barbara
B
Steiner
Golo
G
Kronenberg
D000328:Adult; D000818:Animals; D015415:Biomarkers; D064032:Calbindin 2; D002455:Cell Division; D006624:Hippocampus / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008959:Models, Neurological; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013234:Stem Cells / Q000145:classification / Q000166:cytology* / Q000378:metabolism
D015415:Biomarkers; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G