Nucleoplasmin: a nuclear chaperone.
In this article, we briefly review the structural and functional information currently available on nucleoplasmin. Special emphasis is placed on the discussion of the molecular mechanism involved in the sperm chromatin remodelling activity of this protein. A model is proposed based on current crystallographic data, recent biophysical and functional studies, as well as in the previously available information.
Unidad de Biofísica (CSIC-UPV/EHU), Bilbao, Spain. gbpprrua@lg.ehu.es
Adelina
A
Prado
Isbaal
I
Ramos
Lindsay J
LJ
Frehlick
Arturo
A
Muga
Juan
J
Ausió
D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D018360:Crystallography, X-Ray; D004330:Drosophila; D029721:Drosophila Proteins; D006801:Humans; D008297:Male; D008954:Models, Biological; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D056489:Nucleoplasmins; D010750:Phosphoproteins / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D011487:Protein Conformation; D013094:Spermatozoa / Q000378:metabolism; D014981:Xenopus
D002843:Chromatin; D029721:Drosophila Proteins; D018832:Molecular Chaperones; C533549:Nlp protein, Drosophila; D009687:Nuclear Proteins; D056489:Nucleoplasmins; D010750:Phosphoproteins