Mechanisms underlying the effect of E. coli endotoxin on contractile function of lymphatic vessels.
E. coli endotoxin decreased the amplitude and frequency of spontaneous phasic contractions in isolated bovine mesenteric lymphatic vessels. This substance in a concentration of 5 mg/liter blocked spontaneous contractions and reduced tonic tension of smooth muscle cells. The dilatory effect of endotoxin on lymphatic vessels was primarily realized via stimulation of synthesis of NO and prostacyclin by endotheliocytes.
Lobov
G I
GI
Department of Normal Physiology, I. I. Mechnikov Medical Academy, St. Petersburg, Russia. lobov@infran.ru
Kubyshkina
N A
NA
D000818:Animals; D002417:Cattle; D004731:Endotoxins / Q000633:toxicity*; D011464:Epoprostenol / Q000096:biosynthesis; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D042601:Lymphatic Vessels / Q000187:drug effects* / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis
D004731:Endotoxins; D009569:Nitric Oxide; C044101:endotoxin, Escherichia coli; D011464:Epoprostenol; D019331:NG-Nitroarginine Methyl Ester; D007213:Indomethacin