Linear furanocoumarin protects rat myocardium against lipidperoxidation and membrane damage during experimental myocardial injury.
The antioxidant activity and the membrane effects of linear furanocoumarin marmesinin isolated from Aegle marmelose was evaluated during experimental myocardial injury. Isoproterenol (150 mg kg(-1) intraperitonially twice at an interval of 24 h) caused increase in the levels of serum marker enzymes via creatinekinase (CK), creatinekinase-MB (CK-MB) isoenzyme, lactatedehydrogenase (LDH) and lactatedehydrogenase isoenzyme (LDH1). It also produced electrocardiographic changes such as increased heart rate, reduced R amplitude and ST elevation. Marmesinin at a dose of 200 mg kg(-1), when administered orally, demonstrated a decrease in serum enzyme levels and restored the electrocardiographic changes towards normalcy. Myocardial injury was accompanied by the disintegration of lipidperoxides and the impairment of natural scavengers. Marmesinin oral treatment for 2 days before and during isoproterenol administration decreased the effect of lipidperoxidation. It was also shown to have a membrane stabilizing action by inhibiting the release of beta-glucuronidase from the subcellular fractions. Thus, linear furanocoumarin marmesinin could have the protective effect against the damage caused by experimental myocardial injury.
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India. veereshwar_v@yahoo.com
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D045471:Aegle; D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D003374:Coumarins / Q000494:pharmacology*; D003402:Creatine Kinase / Q000378:metabolism; D004562:Electrocardiography; D005663:Furans / Q000494:pharmacology*; D007527:Isoenzymes / Q000378:metabolism; D007545:Isoproterenol; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
D003374:Coumarins; D005663:Furans; D007527:Isoenzymes; C495190:marmesinin; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D007545:Isoproterenol