Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so.
While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human V gamma 9/V delta 2 T cells.
Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. matthias.eberl@biochemie.med.uni-giessen.de
Matthias
M
Eberl
Martin
M
Hintz
Zandraa
Z
Jamba
Ewald
E
Beck
Hassan
H
Jomaa
Gunna
G
Christiansen
D000818:Animals; D011756:Diphosphates / Q000276:immunology* / Q000378:metabolism; D004896:Erythritol / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D009174:Mycoplasma / Q000276:immunology / Q000378:metabolism; D018661:Mycoplasma penetrans / Q000235:genetics / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D013403:Sugar Phosphates / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D013729:Terpenes / Q000378:metabolism
C114232:2-C-methylerythritol 4-phosphate; C443995:4-hydroxy-3-methylbut-2-enyl pyrophosphate; D011756:Diphosphates; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013403:Sugar Phosphates; D013729:Terpenes; D004896:Erythritol