Caspase activation, inhibition, and reactivation: a mechanistic view.
Caspases, a unique family of cysteine proteases, execute programmed cell death (apoptosis). Caspases exist as inactive zymogens in cells and undergo a cascade of catalytic activation at the onset of apoptosis. The activated caspases are subject to inhibition by the inhibitor-of-apoptosis (IAP) family of proteins. This inhibition can be effectively removed by diverse proteins that share an IAP-binding tetrapeptide motif. Recent structural and biochemical studies have revealed the underlying molecular mechanisms for these processes in mammals and in Drosophila. This paper reviews these latest advances.
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA. yshi@molbio.princeton.edu
Yigong
Y
Shi
D020816:Amino Acid Motifs; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000737:chemistry* / Q000378:metabolism*; D004330:Drosophila / Q000378:metabolism; D004789:Enzyme Activation / Q000502:physiology; D004793:Enzyme Reactivators / Q000378:metabolism; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008322:Mammals / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
D004793:Enzyme Reactivators; D051034:Inhibitor of Apoptosis Proteins; D011506:Proteins; D020169:Caspases