[Synthesis of N1-(aryl)alkyloxyacyl-5-fluorouracil derivatives].
OBJECTIVE
To synthesize N1-(aryl)alkyloxyacyl-5-fluorouracil derivatives and investigate their antitumor activities.


METHODS
Title compounds (I) were prepared by 5-fluorouracil which was trimethylsilylated by hexamethyl-di-silazane, and then acylated. Hydrogenization of compounds (I) brought on compounds (II), which were esterified to produce title compounds (III) afterwards.


RESULTS
Twelve title compounds were synthesized.


CONCLUSIONS
These compounds were designed products confirmed by 1H-NMR, IR and MS spectral data.
Hai
Li
L
Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610061, China.
Wu
Lin-yan
LY
Huang
Juan
J
Cheng
Li
L
Wu
Yong
Y
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil