Zoledronate-induced remission of acute panmyelosis with myelofibrosis.
Acute panmyelosis with myelofibrosis is a rare and aggressive form of acute myeloid leukemia. We describe a new case with a huge proliferation of megakaryocytes, blast cells and reticulin fibers. The patient was treated with zoledronate, a third-generation bisphosphonate, and a gradual recovery from pancytopenia was observed. A new bone marrow biopsy performed 4 months later showed a surprising disappearance of the leukemic infiltration. Ten months after the diagnosis, the patient is still in healthy condition. This may support the recently described anti-tumor activity of zoledronate.
Español
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Servicio de Oncología, Hospital General de l'Hospitalet, Barcelona, Spain. iem28602@worldonline.es
Romagosa
V
V
Berlanga
J
J
Domingo
A
A
Losa
F
F
Heras
L
L
Janáriz
J
J
D000208:Acute Disease; D000368:Aged; D001772:Blood Cell Count; D001803:Blood Transfusion; D001856:Bone Marrow Examination; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D055728:Primary Myelofibrosis / Q000188:drug therapy*; D012074:Remission Induction / Q000379:methods; D000077211:Zoledronic Acid
D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid