The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease.
luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod (Ixodes scapularis) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick transmitted to uninfected mice, and elicited histopathology in mice indistinguishable from that induced by wild-type B. burgdorferi.
Blevins
Jon S
JS
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, 75390, USA.
Revel
Andrew T
AT
Caimano
Melissa J
MJ
Yang
Xiaofeng F
XF
Richardson
James A
JA
Hagman
Kayla E
KE
Norgard
Michael V
MV
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D001733:Bites and Stings; D025065:Borrelia burgdorferi / Q000254:growth & development* / Q000472:pathogenicity* / Q000502:physiology; D013437:Carbon-Sulfur Lyases; D005260:Female; D018884:Ixodes / Q000382:microbiology*; D008193:Lyme Disease / Q000382:microbiology / Q000473:pathology / Q000635:transmission*; D051379:Mice; D008809:Mice, Inbred C3H; D009154:Mutation
D001426:Bacterial Proteins; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria