Diagnostic accuracy of Fischer Senoscan Digital Mammography versus screen-film mammography in a diagnostic mammography population.
OBJECTIVE
To compare the diagnostic accuracy of the Fischer Senoscan Digital Mammography System with that of standard screen-film mammography in a population of women presenting for screening or diagnostic mammography.


METHODS
Enrollment of patients took place at six different breast-imaging centers between 1997 and 1999. A total of 247 cases were selected for inclusion in the final reader study. All known cancer cases were included (111) from all six participating sites representing 45% of the total cases. The remaining 136 cases (55%) were randomly selected from all available benign or negative cases from three of the six sites. A complete case consisted of both a (unilateral or bilateral) digital and screen-film mammogram of the same patient. Eight radiologists interpreted the cases in laser-printed digital and screen-film hardcopy formats. The study was designed to detect differences of 0.05 in the ROC area under the curve (AUC) between digital and screen-film radiologist interpretation performance.


RESULTS
The average AUC for the Senoscan digital was 0.715 for the 8 readers. The average AUC for screen-film was 0.765. The difference AUC of -0.05 falls within the 95% confidence interval (-0.101, 0.002). The average sensitivity was 66% and specificity 67% for SenoScan full-field digital mammography. The average screen-film mammography sensitivity and specificity were 74% and 60%, respectively.


CONCLUSIONS
No statistically significant difference in diagnostic accuracy between the Fischer Senoscan and screen-film mammography was detected in this study.
Cole
Elodia
E
Department of Radiology, University of North Carolina at Chapel Hill 106 Mason Farm Road, Chapel Hill, NC 27599-7510, USA. ecole@med.unc.edu
Pisano
Etta D
ED
Brown
Mary
M
Kuzmiak
Cherie
C
Braeuning
M Patricia
MP
Kim
Hak Hee
HH
Jong
Roberta
R
Walsh
Ruth
R
D000328:Adult; D019540:Area Under Curve; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008327:Mammography / Q000379:methods*; D008403:Mass Screening; D012372:ROC Curve; D011856:Radiographic Image Enhancement / Q000379:methods*; D012680:Sensitivity and Specificity; D014963:X-Ray Intensifying Screens