The effects of dietary bioflavonoid (rutin, quercetin, and naringin) supplementation on physiological changes in molar crestal alveolar bone-cemento-enamel junction distance in young rats.
The objective of this study was to evaluate the influence of dietary bioflavonoid (rutin [R], quercetin [Q], and naringin [N]) supplementation on physiological molar crestal alveolar bone(CAB)-cemento-enamel junction (CEJ) distances in young male albino rats. The effects of diets supplemented with 0.57% R, Q, or N, at the expense of dextrose, were tested on 40 young rats, divided into four groups, for a period of 42 days. Rat skulls were defleshed, and CAB-CEJ distance was scored according to the modified method of Keyes and Gold (Oral Surg Oral Med Oral Pathol 1955;8:492). Data were analyzed using one-way analysis of variance, post hoc Tukey's test, and Spearman's (R(2)) correlation. P <.05 was used to reject the null hypothesis. The N group demonstrated the lowest CAB-CEJ distance, followed by the R and Q groups (P <.001-.05), except in the mandibular lingual region, where the Q group had a lower CAB-CEJ distance than the N and R groups (P <.05). The control group showed the largest CAB-CEJ distances. Dietary bioflavonoid supplementation was shown to significantly reduce molar CAB-CEJ distance (P <.001-.05) during alveolar development in male young rats.
Wood
Nelson
N
Department of Periodontics and Preventive Sciences, University of Mississippi School of Dentistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, U.S.A. nwood@sod.umsmed.edu
D000818:Animals; D019587:Dietary Supplements; D044950:Flavanones / Q000008:administration & dosage*; D008334:Mandible / Q000033:anatomy & histology* / Q000187:drug effects / Q000254:growth & development; D008437:Maxilla / Q000033:anatomy & histology* / Q000187:drug effects / Q000254:growth & development; D011794:Quercetin / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012431:Rutin / Q000008:administration & dosage*; D019237:Tooth Cervix / Q000033:anatomy & histology* / Q000254:growth & development
D044950:Flavanones; D012431:Rutin; D011794:Quercetin; C005274:naringin