Update on zona pellucida glycoproteins based contraceptive vaccine.
Zona pellucida (ZP) glycoproteins, due to their critical role in mammalian fertilization, have been proposed as candidate immunogens for development of a contraceptive vaccine. Active immunization studies in a variety of animal species, employing either native or recombinant zona proteins, has established their contraceptive potential. Hence, ZP glycoprotein-based contraceptive vaccines have a very good potential for controlling wild life population. To make it a realistic proposition, additional research inputs are required to develop new potent adjuvants and novel practical strategies for vaccine delivery. The observed ovarian dysfunction, often associated with immunization by ZP glycoproteins, is one of the major obstacles for their application in the control of human population. Ongoing studies to delineate epitopes of ZP glycoproteins that will generate an immune response capable of inhibiting fertility without any untoward effects on ovarian functions will help in determining their feasibility for human use.
Gupta
S K
SK
Gamete Antigen Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 1100 67, India. skgupta@nii.res.in
Srivastava
Neelu
N
Choudhury
Sangeeta
S
Rath
Archana
A
Sivapurapu
Neela
N
Gahlay
G K
GK
Batra
Deepika
D
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D003269:Contraception, Immunologic / Q000009:adverse effects; D004527:Egg Proteins / Q000276:immunology* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects / Q000276:immunology; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology / Q000494:pharmacology; D022642:Vaccines, Contraceptive / Q000009:adverse effects / Q000276:immunology*; D000072216:Zona Pellucida Glycoproteins
D000276:Adjuvants, Immunologic; D004527:Egg Proteins; D008562:Membrane Glycoproteins; D010455:Peptides; D011956:Receptors, Cell Surface; D011994:Recombinant Proteins; D022642:Vaccines, Contraceptive; D000072216:Zona Pellucida Glycoproteins