Symptomatic antiepileptic drug associated vitamin D deficiency in noninstitutionalized patients: an under-diagnosed disorder.
Four noninstitutionalized patients, 4 months - 51 years old, presented out of 421 patients with epilepsy seen within a period of 2 years with serious symptoms of vitamin D deficiency secondary to chronic antiepileptic drug therapy. Presenting symptoms included exacerbation of seizure activity, status epilepticus, carpopedal spasms, fractures, osteomalacia, and rickets. All had low serum calcium and low vitamin D levels. Our experience supports the practice of screening patients on chronic antiepileptic drug therapy for vitamin D abnormalities.
Department of Pediatrics/Adult and Pediatric Epilepsy Program, American University of Beirut, 3 Dag Hammarskjold Plaza, 8th Floor, New York, NY 10017-2303, USA. mamikati@aub.edu.lb
Mohamad
M
Mikati
Rima Hanna
RH
Wakim
Michel
M
Fayad
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D014808:Vitamin D Deficiency / Q000139:chemically induced* / Q000175:diagnosis*
D000927:Anticonvulsants