[Atherogenesis as an immunoinflammatory process].
The paper contains findings, obtained at the laboratory of atherosclerosis of Anichkov's Research Institute of Experimental Medicine, Russia's Academy of Medical Sciences, during the last decade with the above research results being compared with published data. Atherogenesis is discussed from the standpoint of the development of immune inflammation in the arterial wall. The mechanisms and factors triggering the chain of immunoinflammatory reactions, which provoke and keep up the inflammatory process, are also under discussion. The results are indicative of that the atherosclerosis pathogenesis is equally related both with mLDL and with the reaction developing in the vascular wall.
Nagornev
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VA
Voskan'iants
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AN
D001011:Aorta / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D001055:Apolipoproteins B / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology; D002339:Carotid Arteries / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D003324:Coronary Artery Disease / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008075:Lipoproteins, HDL / Q000276:immunology
D001055:Apolipoproteins B; D001323:Autoantibodies; D008075:Lipoproteins, HDL; C026277:very high density lipoproteins