Improvement in biocompatibility of ZrO2-Al2O3 nano-composite by addition of HA.
The biocompatibility of zirconia-alumina (ZA) nano-composites in load-bearing applications such as dental/orthopedic implants was significantly enhanced by the addition of bioactive HA. The ZA matrix was composed of nano-composite powder obtained from the Pechini process and had higher flexural strength than conventionally mixed zirconia-alumina composite. Because the ZA nano-composite powder effectively decreased the contact area between HA and zirconia for their reaction during the sintering process, the HA-added ZA nano-composites contained biphasic calcium phosphates (BCP) of HA/TCP and had higher flexural strength than conventionally mixed ZA-HA composite. From the in vitro test with osteoblastic cell-lines, the proliferation and the differentiation (as expressed by the alkaline phosphatase activity) of the cellular response on the HA-added ZA nano-composites gradually increased as the amount of HA added increased. From the mechanical and biological evaluations of the HA-added ZA nano-composites, 30HA (30 vol% HA + 70 vol% ZA) was found to be the optimal composition for load-bearing biological applications.
School of Materials Science and Engineering, Seoul National University, Seoul 151-744, South Korea.
Young-Min
YM
Kong
Chang-Jun
CJ
Bae
Su-Hee
SH
Lee
Hae-Won
HW
Kim
Hyoun-Ee
HE
Kim
D000469:Alkaline Phosphatase / Q000032:analysis; D000537:Aluminum Oxide / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001859:Bone Neoplasms / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D017886:Durapatite / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D009363:Neoplasm Proteins / Q000032:analysis; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D012516:Osteosarcoma / Q000473:pathology; D011208:Powders; D016474:Weight-Bearing; D015040:Zirconium / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity
D001672:Biocompatible Materials; D009363:Neoplasm Proteins; D011208:Powders; D017886:Durapatite; D015040:Zirconium; D000469:Alkaline Phosphatase; D000537:Aluminum Oxide; C028541:zirconium oxide