DD genotype of ACE gene is a risk factor for intracerebral hemorrhage.
Genetic factors may play a role in susceptibility to stroke. The angiotensin converting enzyme (ACE) gene is a candidate gene for two phenotypically different types of stroke affecting small perforating arteries: spontaneous intracerebral hemorrhage (SIH) and ischemic stroke due to small vessel disease (SVD). The authors report evidence that ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for SIH, and not for SVD stroke, in a Polish population.
Department of Neurology, Jagiellonian University, Medical College, 31-503 Krakow, Botaniczna 3, Poland. slowik@neuro.cm-uj.krakow.pl
A
A
Slowik
W
W
Turaj
T
T
Dziedzic
A
A
Haefele
J
J
Pera
M T
MT
Malecki
L
L
Glodzik-Sobanska
P
P
Szermer
D A
DA
Figlewicz
A
A
Szczudlik
D000328:Adult; D000368:Aged; D000483:Alleles; D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000235:genetics*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
D007703:Peptidyl-Dipeptidase A