Urgently needed: a filter for the HIV-1 vaccine pipeline.
Research groups worldwide are trying to make immunogens intended to elicit neutralizing antibody responses as part of a prophylactic vaccine to counter the spread of HIV-1. The relative merits of different designs can only be gauged properly through comparative studies, and particularly by evaluating human or animal antisera under identical, or comparable, conditions. Hence there is a need for assay standardization and for the creation of a centralized testing facility that could distribute consensus protocols and reagents.
Moore
John P
JP
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA. jpm2003@med.cornell.edu
Burton
Dennis R
DR
D016915:AIDS Vaccines; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D015195:Drug Design; D015483:HIV Antibodies / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D009500:Neutralization Tests / Q000379:methods*
D016915:AIDS Vaccines; D015483:HIV Antibodies