Acute effects of sildenafil on Humphrey visual field and intraocular pressure.
OBJECTIVE
To evaluate the effects of sildenafil on visual field and intraocular pressure in a group of healthy subjects.


METHODS
Twenty-eight healthy male volunteers with normal eyes were included in the study. Visual field examinations were performed using FASTPAC 30-2 program (white-on-white and blue-on-yellow) with the Humphrey field analyzer before and one hour after receiving oral 50 and 100 mg sildenafil citrate.


RESULTS
The mean age was 51.1 +/- 8.9 years. Mean deviation, pattern standard deviation, short-term fluctuation and corrected pattern standard deviation did not differ significantly among tests both in white-on-white and blue-on-yellow visual field examinations. Changes in intraocular pressure were not statistically significant.


CONCLUSIONS
No significant effect of sildenafil was seen on visual field and intraocular pressure in healthy subjects.
Department of Ophthalmology, School of Medicine, University of Afyon Kocatepe, Afyon, Turkey. sametermis@hotmail.com
Sitki Samet
SS
Ermis
Umit Ubeyt
UU
Inan
Murat
M
Samli
Faruk
F
Ozturk
D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000328:Adult; D000368:Aged; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014065:Tonometry, Ocular; D058609:Visual Field Tests; D014794:Visual Fields / Q000187:drug effects*
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D015106:3',5'-Cyclic-GMP Phosphodiesterases