Histological findings in a human autogenous pasteurized bone graft.
BACKGROUND
Autogenous bone graft after pasteurization is one of the most valuable procedures for reconstruction of large bone defects following excision of malignant musculoskeletal tumors. To date, there have been no documented histological reports on pasteurized bone grafts, apart from short-term histological results.


METHODS
We treated a 27-year-old male with a periosteal chondrosarcoma of the tibia by wide excision and reimplantation of the large pasteurized bone. Biopsy specimens harvested from the pasteurized bone over 3 years after reimplantation were evaluated histologically. The graft cortices remained totally necrotic with empty osseous lacuna, whereas the architecture of the acellular cortical bones was still maintained without microfractures. Deposited seams of woven bone existed focally on the surface of the acellular trabeculae.


CONCLUSIONS
Our medium-term histological outcome suggests the limitations of incorporating a pasteurized hone graft, but also advocates its role as a useful temporary material for the reconstruction of massive bone defects.
Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan. kubot@hiroshima-u.ac.jp
Tadahiko
T
Kubo
Takashi
T
Sugita
Shoji
S
Shimose
Koji
K
Arihiro
Haruyuki
H
Tanaka
Hiroo
H
Nobuto
Kumi
K
Tanaka
Mitsuo
M
Ochi
D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods / Q000473:pathology*; D002813:Chondrosarcoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D013242:Sterilization; D013977:Tibia / Q000473:pathology / Q000601:surgery; D014182:Transplantation, Autologous / Q000379:methods / Q000473:pathology