Synthesis and identification of two potential oxidation degradants of oxymetazoline.
Two potential oxidation degradants of oxymetazoline have been isolated by liquid chromatography and monitored by electrospray single quadrupole mass spectrometry. The structures of the products are shown to be oxymetazoline N-oxide and hydroxyamine by multiple-stage fragmentation ion trap mass spectrometry. The product ion spectra were installed in a library database and the library was used to examine an aged commercial product; one of the degradants was detected, but at a level of less than 0.1% of the parent.
Leader
Ian P
IP
Royal Holloway, Egham TW20 0EX, UK. leader.i@pg.com
Halket
John
J
Finch
Paul
P
D000996:Antitussive Agents / Q000737:chemistry; D002853:Chromatography, Liquid / Q000379:methods; D003915:Dextromethorphan / Q000737:chemistry; D004355:Drug Stability; D014663:Nasal Decongestants / Q000737:chemistry*; D004366:Nonprescription Drugs / Q000737:chemistry*; D010084:Oxidation-Reduction; D010109:Oxymetazoline / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
D000996:Antitussive Agents; D014663:Nasal Decongestants; D004366:Nonprescription Drugs; D003915:Dextromethorphan; D010109:Oxymetazoline