cdc2-related protein kinases and cell cycle control in trypanosomatids.
The molecular mechanisms that control the cell cycle have been studied extensively in yeast and higher eukaryotes. Investigations have centred on the cyclin-dependent kinase family of serine/threonine protein kinases, the best characterized of which is cdc2, a key regulatory element in the control of mitosis. Cell cycle control plays an important role in trypanosomes and Leishmania, not only in cellular proliferation, but also in the developmental system that controls the transfer of the parasite between hosts. In this review, Jeremy Mottram compares the family of trypanosome cdc2-related kinases with that of yeast and the higher eukaryotes.
Wellcome Unit of Molecular Parasitology, Institute of Genetics, University of Glasgow, Church Street, Glasgow, UK GII 5JS.
J C
JC
Mottram