[Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults].
We collected 6 case-reports of symptomatric non removable low grade fibrillary astrocytoma of adults treated with a procarbazine-CCNU-vincristine chemotherapy regimen. All patients had drug-resistant epilepsy but brain imaging was stable. Total gross resection was rejected because of Volume or tumor location. After 4 to 7 cycles of chemotherapy, 2 patients had partial response and one minor response on brain MRI. All of them were seizure-free. Progression free survival was not reached at 5 Years. Up-front chemotherapy for low-grade astrocytomas may be useful and has to be prospectively evaluated.
Lebrun
C
C
Service de Neurologie, Hôpital Pasteur, Nice, France. lebrun.c@chu-nice.fr
Fontaine
D
D
Vandenbos
F
F
Chanalet
S
S
Bourg
V
V
Frénay
M
M
Alchaar
H
H
Bleuse
A
A
Bondiau
P Y
PY
Brunetto
J L
JL
Chatel
M
M
Courdi
A
A
Darcourt
J
J
Fauchon
F
F
Guibert
F
F
Grellier
P
P
Lanteri-Minet
M
M
Lonjon
M
M
Michiels
J F
JF
Paquis
P
P
Paquis
V
V
Ramaioli
A
A
Rasendrarijao
D
D
D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001254:Astrocytoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D018450:Disease Progression; D004351:Drug Resistance; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011344:Procarbazine / Q000008:administration & dosage / Q000009:adverse effects; D014750:Vincristine / Q000008:administration & dosage
D000972:Antineoplastic Agents, Phytogenic; D011344:Procarbazine; D014750:Vincristine; D008130:Lomustine