Interferon induced Autoimmune Thyroid Disease (AITD): a model for human autoimmunity.
Interferon (IFN) alpha treatment for various conditions has been associated with thyroid autoimmunity. The incidence of interferon induced thyroid autoimmunity has been reported to range from 2.5% to 42%, possibly depending upon dose and duration of medical therapy and patient characteristics. It is not known whether IFN-alpha initiates autoimmune thyroid disease (AITD) or simply exacerbates AITD in individuals with subclinical AITD.
Oppenheim
Yael
Y
Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, P.O. Box 1055, One Gustave L. Levy Place, New York, NY 10029, USA.
Ban
Yoshiyuki
Y
Tomer
Yaron
Y
D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects*; D004195:Disease Models, Animal; D006801:Humans; D007372:Interferons / Q000009:adverse effects*; D012307:Risk Factors; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced* / Q000276:immunology
D000998:Antiviral Agents; D007372:Interferons