The hippocampal role in spatial memory and the familiarity--recollection distinction: a case study.
Memory for object locations and for events (comprising the receipt of an object) was tested in a case of developmental amnesia with focal hippocampal damage. Tests used virtual reality environments and forced-choice recognition with foils chosen to equalize the performance of control participants across conditions. Memory for the objects received was unimpaired, but the context of their receipt was forgotten. Memory for short lists of object locations was unimpaired when tested from the same viewpoint as presentation but impaired when tested from a shifted viewpoint. Same-view performance was disrupted by changing the background scene. These results are consistent with Jon having preserved matching to fixed sensory-bound representations but impaired reconstructed or manipulable representations underlying shifted-viewpoint recognition and episodic recollection.
University College London, London, United Kingdom.
John A
JA
King
Iris
I
Trinkler
Tom
T
Hartley
Faraneh
F
Vargha-Khadem
Neil
N
Burgess
D000328:Adult; D000647:Amnesia / Q000503:physiopathology; D001238:Asphyxia Neonatorum; D001245:Association Learning / Q000502:physiology; D001925:Brain Damage, Chronic / Q000503:physiopathology; D003463:Cues; D004193:Discrimination Learning / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology; D012153:Retention, Psychology / Q000502:physiology*; D012931:Social Environment; D013028:Space Perception / Q000502:physiology*; D014163:Transfer, Psychology; D014584:User-Computer Interface