Complete amino acid sequence and phylogenetic analysis of a long-chain neurotoxin from the venom of the African banded water cobra, Boulengerina annulata.
The sequence of a long-chain neurotoxin (71 amino acid residues, 10 half-cystines) from the venom of the African banded water cobra (Boulengerina annulata) was determined by Edman degradation. It exhibits high sequence similarity with long-chain neurotoxins from the venoms of four species of African cobras (genus Naja), which are collectively more similar to the Boulengerina toxin than to those of Asian Naja species. These results are discussed in the light of phylogenetic hypotheses on the relationships of African cobras.
Institute of Medicinal Chemistry, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Yuko
Y
Ogawa
Ryohei
R
Yanoshita
Ulrich
U
Kuch
Yuji
Y
Samejima
Dietrich
D
Mebs
D000595:Amino Acid Sequence; D000818:Animals; D016000:Cluster Analysis; D003039:Cobra Neurotoxin Proteins / Q000737:chemistry / Q000235:genetics*; D017815:Elapidae / Q000235:genetics*; D007928:Lethal Dose 50; D008969:Molecular Sequence Data; D009943:Organophosphorus Compounds; D010802:Phylogeny; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein
C043517:2-(4-isothiocyanatophenoxy)-1,3,2-dioxaphosphinene 2-oxide; D003039:Cobra Neurotoxin Proteins; D009943:Organophosphorus Compounds