Structures of four methyltetrazole-containing antiviral compounds in human rhinovirus serotype 14.
Four novel antiviral WIN compounds, that contain a methyl tetrazole ring as well as isoxazole, pyridazine or acetylfuran rings, have had their structures determined in human rhinovirus serotype 14 at 2.9 A resolution. These compounds bind in the VP1 hydrophobic pocket, but are shifted significantly towards the pocket pore when compared to previously examined WIN compounds. A putative water network at the pocket pore is positioned to hydrogen bond with these four WIN compounds, and this network can account for potency differences seen in structurally similar WIN compounds.
Sterling Winthrop Pharmaceuticals Research Division, Collegeville, PA 19426-0900, USA.
V L
VL
Giranda
G R
GR
Russo
P J
PJ
Felock
T R
TR
Bailey
T
T
Draper
D J
DJ
Aldous
J
J
Guiles
F J
FJ
Dutko
G D
GD
Diana
D C
DC
Pevear
M
M
McMillan