Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice.
We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginine in NMRI mice. Atropine reduced, while hexamethonium completely abolished the arrhythmogenic effect of endothelin-1 during nitric oxide synthase inhibition. Atenolol potentiated arrhythmogenic activity of Nomega-nitro-L-arginine, but endothelin-1 had no effect on the incidence of arrhythmias under these conditions.
Lobanov
A V
AV
Laboratory of Biological Assays, Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia. lobanov_al@pisem.net
Rzhevskii
D I
DI
Korshunov
V A
VA
Murashev
A N
AN
D018674:Adrenergic Antagonists / Q000494:pharmacology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D001262:Atenolol / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D019332:Endothelin-1 / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D008297:Male; D051379:Mice; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis
D018674:Adrenergic Antagonists; D018680:Cholinergic Antagonists; D019332:Endothelin-1; D009569:Nitric Oxide; D018738:Hexamethonium; D001262:Atenolol; D001285:Atropine; D019331:NG-Nitroarginine Methyl Ester