Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis.
It has been reported that excretory-secretory (ES) material from the parasitic nematode Nippostrongylus brasiliensis has potential modulatory effects on the host's immune system. We observed that intratracheal instillation of ES from the L3 stage of the parasite reduced neutrophil numbers in LPS-induced inflammation as assessed by bronchoalveolar lavage.
School of Life Sciences, Napier University, Edinburgh, UK.
P A
PA
Keir
D M
DM
Brown
A
A
Clouter-Baker
Y M
YM
Harcus
L
L
Proudfoot
D000818:Animals; D000947:Antigens, Helminth / Q000008:administration & dosage; D005260:Female; D006790:Host-Parasite Interactions / Q000276:immunology; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008168:Lung / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D009559:Nippostrongylus / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity*; D051381:Rats; D017208:Rats, Wistar; D017206:Strongylida Infections / Q000276:immunology
D000947:Antigens, Helminth; D008070:Lipopolysaccharides