Relationship between changes in rat behavior and integral biochemical indexes determined by laser correlation spectroscopy after photothrombosis of the prefrontal cortex.
Experiments on rats showed that Noopept improved retention and retrieval of conditioned passive avoidance response after phototrombosis of the prefrontal cortex (a procedure impairing retention of memory traces). The impairment of mnesic functions was accompanied by changes in integral biochemical indexes of the plasma determined by laser correlation spectroscopy. Treatment of behavioral disorders with Noopepet normalized biochemical indexes.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
G A
GA
Romanova
F M
FM
Shakova
O I
OI
Kovaleva
V V
VV
Pivovarov
N N
NN
Khlebnikova
M Yu
MY
Karganov
D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D004151:Dipeptides / Q000494:pharmacology; D020767:Intracranial Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D007834:Lasers; D008297:Male; D009043:Motor Activity; D018462:Photobiology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000293:injuries* / Q000503:physiopathology; D051381:Rats; D013057:Spectrum Analysis
D004151:Dipeptides; C103871:ethyl phenylacetyl-Pro-Gly