[Gender difference in alcoholic liver injury].
Gender differences of alcoholic liver injury have been described previously, but mechanisms have only partially characterized. For example, it is known that females develop alcoholic liver injury more rapidly and to a greater extent than males. It now appears that estrogen participates in several aspects of this phenomenon. On the other hand, attention has been directed towards the effect of ethanol ingestion on Kupffer cell function, which is stimulated by gut-derived endotoxins via mechanisms dependent on increased gut permeability and the possible relationship between Kupffer cell and alcohol-induced liver injury.
Enomoto
Nobuyuki
N
Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Takei
Yoshiyuki
Y
Yamashina
Shunhei
S
Ikejima
Kenichi
K
Suzuki
Satoko
S
Kitamura
Tsuneo
T
Sato
Nobuhiro
N
D005260:Female; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000453:epidemiology*; D008297:Male; D012737:Sex Factors