Progressive epidermotropic CD8+/CD4- primary cutaneous CD30+ lymphoproliferative disorder in a patient with sarcoidosis.
We describe a patient with a CD8+/CD4- primary cutaneous CD30(+) lymphoproliferative disorder with striking epidermotropic histology and coincident cutaneous and systemic sarcoidosis. This patient illustrates the spectrum of clinical and histologic features of CD30+ lymphoproliferative disorders and the need for adequate staging in such cases. This patient's CD30/CD8 coexpression is rare and has clinical and prognostic implications, including mucosally and acrally accentuated lesions and a potentially more aggressive course. Primary cutaneous CD30+ lymphoproliferative disorders have an excellent prognosis; therefore multiagent chemotherapy modalities are generally not indicated. The combination of T-cell lymphoma and sarcoidosis is also rare and may limit treatment options.
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia 19102, USA.
Joel M
JM
Gelfand
Mariusz A
MA
Wasik
Carmela
C
Vittorio
Alain
A
Rook
Jacqueline M
JM
Junkins-Hopkins
D000328:Adult; D001706:Biopsy; D016516:CD4-CD8 Ratio; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology* / Q000473:pathology*; D008297:Male; D012507:Sarcoidosis / Q000150:complications*
D017730:Ki-1 Antigen