Induction of NO-synthase and acetaldehyde dehydrogenase in neurons of human cerebellar cortex during chronic alcohol intoxication.
Induction of NO-synthase and acetaldehyde dehydrogenase in Purkinje cells, basket-like neurons, and microvascular endothelium of human cerebellar cortex was detected in patients with chronic alcohol intoxication. It was hypothesized that the neuromodulating effect of NO is associated with mechanisms protecting neurons from toxic effects of ethanol and acetaldehyde.
Konovko
O O
OO
Department of Histology, Vladivostok State Medical University, Moscow. konovko@mail.primorye.ru
Morozov
Yu E
YE
Kalinichenko
S G
SG
Dyuzen
I V
IV
Motavkin
P A
PA
D000328:Adult; D000437:Alcoholism / Q000201:enzymology*; D000445:Aldehyde Oxidoreductases / Q000096:biosynthesis*; D002525:Cerebellar Cortex / Q000201:enzymology*; D004730:Endothelium, Vascular / Q000201:enzymology; D004790:Enzyme Induction; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009252:NADPH Dehydrogenase / Q000096:biosynthesis; D009474:Neurons / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D011689:Purkinje Cells / Q000201:enzymology
D019001:Nitric Oxide Synthase; D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+); D009252:NADPH Dehydrogenase