Comparison of aortic dissection in patients with and without Marfan's syndrome (results from the International Registry of Aortic Dissection).
Among 1,049 patients diagnosed with aortic dissection in a multinational registry, patients with Marfan's syndrome were typically younger and had unique presentations. Despite their younger age at presentation, patients with Marfan's syndrome and aortic dissection had a high mortality rate, similar to patients without Marfan's syndrome, an older patient cohort. Our data support the importance of aneurysm surveillance and prophylactic surgical intervention for patients with Marfan's syndrome to potentially reduce the risk of mortality.
Januzzi
James L
JL
Thoracic Aorta Center and Cardiology Division, Massachusetts General Hospital, Boston, 02114, USA. jjanuzzi@partners.org
Marayati
Firas
F
Mehta
Rajendra H
RH
Cooper
Jeanna V
JV
O'Gara
Patrick T
PT
Sechtem
Udo
U
Bossone
Eduardo
E
Evangelista
Arturo
A
Oh
Jae K
JK
Nienaber
Christoph A
CA
Eagle
Kim A
KA
Isselbacher
Eric M
EM
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000784:Aortic Dissection / Q000175:diagnosis / Q000453:epidemiology*; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007391:International Cooperation; D008297:Male; D008382:Marfan Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D011336:Probability; D012016:Reference Values; D012042:Registries; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis