Multicenter evaluation of a new screening test that detects Clostridium difficile in fecal specimens.
Clostridium difficile causes approximately 25% of nosocomial antibiotic-associated diarrheas and most cases of pseudomembranous colitis. We evaluated C. DIFF CHEK, a new screening test that detects glutamate dehydrogenase of C. difficile. Our results showed that this test was comparable to PCR in sensitivity and specificity and outperformed bacterial culture.
Zheng
L
L
TechLab, Inc., 2001 Kraft Dr., Blacksburg, VA 24061, USA. zhengl@techlab.com
Keller
S F
SF
Lyerly
D M
DM
Carman
R J
RJ
Genheimer
C W
CW
Gleaves
C A
CA
Kohlhepp
S J
SJ
Young
S
S
Perez
S
S
Ye
K
K
D015415:Biomarkers / Q000032:analysis; D016360:Clostridioides difficile / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D003428:Cross Infection / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control; D003967:Diarrhea / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis* / Q000517:prevention & control; D005243:Feces / Q000382:microbiology*; D005969:Glutamate Dehydrogenase / Q000032:analysis*; D006801:Humans; D008403:Mass Screening / Q000379:methods; D016133:Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity
D015415:Biomarkers; D005969:Glutamate Dehydrogenase