Effects of bushen huoxue decoction on nitric oxide (NO) in serum, articular cartilage and synovium in rabbits of knee osteoarthritis.
Forty-eight New Zealand rabbits were divided into normal group (n=18), control group (n=18) and Chinese herbs treatment group (n=12) randomly. The rabbits in the normal group received sham-operation, and the OA model was established by Hulth's method. All the rabbits in the treatment group were given bushen huoxue decoction from the 6th week after the operation. At 6th, 8th and 12th week after the operation, the NO concentrations of the serum, joint cartilage and synovium were examined.


RESULTS
Indicated that the NO concentrations of the serum, joint cartilage and synovium in the control group were all significantly higher than those in the normal group, with the joint cartilage more obvious (P<0.05). In the Chinese herbs treatment group the NO concentrations in all the parts obviously decreased as compared with the control group (P<0.05). It is suggested that bushen huoxue decoction decrease the levels of NO in the serum, synovium and joint cartilage in the OA rabbit.
Department of Orthopedics Surgery, Second Hospital, Xi'an Jiaotong Uneversity, Xi'an 710061.
Pinglin
P
Yang
Xijing
X
He
Zhi
Z
Yang
Deyu
D
Liu
Haopeng
H
Li
Dong
D
Wang
D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007719:Knee Joint / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D020370:Osteoarthritis, Knee / Q000378:metabolism*; D011817:Rabbits; D011897:Random Allocation; D013583:Synovial Membrane / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide