Excision of the Shigella resistance locus pathogenicity island in Shigella flexneri is stimulated by a member of a new subgroup of recombination directionality factors.
Pathogenicity islands are capable of excision and insertion within bacterial chromosomes. We describe a protein, Rox, that stimulates excision of the Shigella resistance locus pathogenicity island in Shigella flexneri. Sequence analysis suggests that Rox belongs to a new subfamily of recombination directionality factors, which includes proteins from P4, enterohemorrhagic Escherichia coli, and Yersinia pestis.
Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton 3800, Australia.
Shelley N
SN
Luck
Sally A
SA
Turner
Kumar
K
Rajakumar
Ben
B
Adler
Harry
H
Sakellaris
D000595:Amino Acid Sequence; D001435:Bacteriophages / Q000235:genetics; D017124:Conserved Sequence; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D005798:Genes, Bacterial; D044404:Genomic Islands / Q000235:genetics*; D020071:Interspersed Repetitive Sequences; D016366:Open Reading Frames; D010802:Phylogeny; D011995:Recombination, Genetic; D016415:Sequence Alignment; D017385:Sequence Homology; D012763:Shigella flexneri / Q000235:genetics* / Q000472:pathogenicity; D015010:Yersinia pestis / Q000235:genetics
D004269:DNA, Bacterial