Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL.
We studied the potential role of the Duffy antigen and glycophorin A as receptors for rodent malaria parasite invasion of erythrocytes. Parasitemia increased exponentially after infection with Plasmodium berghei NK65, P. chabaudi, and P. vinckei in Duffy antigen knockout, glycophorin A knockout, and wild-type mice, indicating that the Duffy antigen and glycophorin A are not essential for these malaria parasites. However, parasitemia of the Duffy antigen knockout mice infected with P. yoelii 17XL remained constant from day 5 to 14 after infection, and then decreased, resulting in autotherapy. The treatment of P. yoelii 17XL-infected Duffy antigen knockout mice with anti-CD4 antibody increased the parasitemia 15 days after infection and the mice eventually died, indicating that CD-4-positive cells play an important role in the clearance of P. yoelii 17XL at the late stage of the infection.
Akimitsu
Nobuyoshi
N
Laboratory of Developmental Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 3-1, 7-Chome, Hongo, Bunkyo-ku, 113-0033, Japan.
Kim
Hye-Sook
HS
Hamamoto
Hiroshi
H
Kamura
Koushirou
K
Fukuma
Nobuko
N
Arimitsu
Nagisa
N
Ono
Kanako
K
Wataya
Yusuke
Y
Torii
Motomi
M
Sekimizu
Kazuhisa
K
D000818:Animals; D051379:Mice; D000953:Antigens, Protozoan / Q000502:physiology; D000961:Antilymphocyte Serum / Q000008:administration & dosage; D001789:Blood Group Antigens; D015704:CD4 Antigens / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004375:Duffy Blood-Group System / Q000235:genetics / Q000502:physiology; D004912:Erythrocytes / Q000276:immunology / Q000469:parasitology; D006021:Glycophorins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D008288:Malaria / Q000235:genetics / Q000276:immunology / Q000469:parasitology; D018345:Mice, Knockout; D010962:Plasmodium berghei / Q000472:pathogenicity; D016788:Plasmodium chabaudi / Q000472:pathogenicity; D010967:Plasmodium yoelii / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D015800:Protozoan Proteins / Q000502:physiology; D011956:Receptors, Cell Surface / Q000172:deficiency / Q000235:genetics / Q000502:physiology
D000953:Antigens, Protozoan; D000961:Antilymphocyte Serum; D001789:Blood Group Antigens; D015704:CD4 Antigens; C066001:Duffy antigen binding protein, Plasmodium; D004375:Duffy Blood-Group System; D006021:Glycophorins; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface; C483025:Ackr1 protein mouse