The prognostic value of both neuron-specific enolase (NSE) and Cyfra21-1 in small cell lung cancer.
OBJECTIVE
The aim of this study was to verify the prognostic significance of multiple tumour markers in small cell lung cancer (SCLC).


METHODS
We examined seven tumour markers [carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA 19-9), squamous cell carcinoma antigen (SCC), neuron-specific enolase (NSE), cancer antigen 125 (CA125), cytokeratin 19 fragment (Cyfra21-1) and ProGastrin-releasing peptide (ProGRP)] in 57 small cell lung cancer (SCLC) patients.


RESULTS
Univariate analysis showed that NSE and Cyfra21-1 were independent negative prognostic factors along with gender, therapy and lactate dehydrogenase (LDH). Multivariate analysis showed that both NSE and Cyfra21-1 retained their significance as prognostic factors along with therapy and the respective hazard ratios were 3.918 (p=0.0122) and 2.617 (p=0.0318) among the seven tumour markers. The group with both NSE and Cyfra21-1 positive had a worse prognosis than the only NSE-positive group, with the respective hazard ratios being 10.245 (p=0.0004) and 3.913 (p=0.0123).


CONCLUSIONS
The group with both of the markers NSE and Cyfra21-1 positive had a worse prognosis than the only NSE-positive group.
Division of Thoracic Diseases, Chiba Cancer Center, Chuoh-ku Chiba 260-8717, Japan. sando@chiba-cc.jp
Soichiro
S
Ando
Makoto
M
Suzuki
Naoyoshi
N
Yamamoto
Tomohiko
T
Iida
Hideki
H
Kimura
D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000201:enzymology; D005260:Female; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D008175:Lung Neoplasms / Q000097:blood* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D015843:Serpins / Q000097:blood
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D053539:Keratin-19; D015843:Serpins; C102012:antigen CYFRA21.1; C051072:squamous cell carcinoma-related antigen; D007633:Keratins; D010751:Phosphopyruvate Hydratase