Minor pyrano-isoflavones from Eriosema kraussianum: activity-, structure-, and chemical reaction studies.
The isolation and identification of two minor pyrano-isoflavones from Eriosema kraussianum is described. New studies on the original pyrano-isoflavones shows that: (i) kraussianone 2 (a major compound in the plant) can be cyclised under acid conditions, (ii) kraussianones 3 and 5 cause contraction (not relaxation as anticipated) of corpus cavernosum tissue and (iii) the structures proposed previously for 4 and 5 are confirmed by the data obtained from an X-ray study of 5.
School of Chemical and Physical Sciences (Chemistry), University of KwaZulu-Natal, Private Bag XO1, Scottsville, 3209 Pietermaritzburg, South Africa. drewes@nu.ac.za
Siegfried E
SE
Drewes
Marion M
MM
Horn
Fatima
F
Khan
Orde Q
OQ
Munro
Jabu T B
JT
Dhlamini
Christopher
C
Rakuambo
J J Marion
JJ
Meyer
D018360:Crystallography, X-Ray; D007529:Isoflavones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D007529:Isoflavones; C465002:kraussianone 1