Genetic variability in cytochrome P450 3A5 and in vivo cytochrome P450 3A activity: some answers but still questions.
Wilkinson
Grant R
GR
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn 37232-6602, USA . grant.wilkinson@vanderbilt.edu
D001682:Biological Availability; D001711:Biotransformation; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics / Q000378:metabolism; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008874:Midazolam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011336:Probability; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D019389:Cytochrome P-450 CYP2D6; D008874:Midazolam