Presynaptic induction and expression of NMDA-dependent LTP.
It is almost axiomatic in neuroscience that postsynaptically induced NMDA-dependent long-term potentiation (LTP) is a cellular substrate of memory. As a result, memory impairments caused by experimental reductions of NMDA currents are often interpreted as evidence that this form of plasticity is involved in memory formation. However, a recent Nature study indicates that not all NMDA-dependent LTP is induced postsynaptically.
Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Avenue, Newark, NJ 07102, USA. pare@axon.rutgers.edu
Denis
D
Paré
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology*; D008568:Memory / Q000502:physiology; D016202:N-Methylaspartate / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
D016202:N-Methylaspartate