Fish oils--adjuvant therapy in chronic heart failure?
Despite advances in medical management and device therapy, chronic heart failure (CHF) remains a condition of high mortality and poor quality of life. Patients with CHF endure frequent admissions to hospital, with exacerbations of breathlessness or recurrent acute myocardial infarction and have a high incidence of sudden death. A high intake of marine polyunsaturated fatty acids (PUFAs) is associated with lower cardiovascular mortality in the general population, and diabetics, and can reduce cardiovascular deaths post-infarction. Many of the effects of PUFAs could be of benefit in CHF patients. They can improve endothelial function, reduce vascular tone, reduce platelet aggregability, improve myocardial relaxation, stabilize myocardial cells by prolonging the refractory period, and lead to increased appetite and weight gain. They also have potentially important immune-modulating effects, reducing cytokine production and release and altering prostaglandin metabolism. In this review article we discuss the potential benefits of PUFA supplementation in CHF patients using data from clinical trials and in vitro experiments.
Castle Hill Hospital, Castle Road, Cottingham, Hull, UK. klauswitte@hotmial.com
Klaus K A
KK
Witte
Andrew L
AL
Clark
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D002100:Cachexia / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D002908:Chronic Disease; D005227:Fatty Acids / Q000378:metabolism / Q000627:therapeutic use; D005395:Fish Oils / Q000378:metabolism / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D017202:Myocardial Ischemia / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D005227:Fatty Acids; D005395:Fish Oils; D007155:Immunologic Factors