Cerebellar paraganglioma.
Paragangliomas arising as primary neoplasms in the intracranial portion of the central nervous system are relatively uncommon and only have been rarely reported. We report a case of apparent primary paraganglioma arising in the left cerebellar hemisphere in an 11-year-old girl who presented with a 6-month history of headaches. The tumor was marked by a nested architectural pattern (zellballen), delimited by S-100-positive sustentacular cells. Morphologic and immunohistochemical features of the neoplasm are discussed and literature is reviewed regarding involvement of the central nervous system by paraganglioma.
Prayson
Richard A
RA
Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA.
Chahlavi
Ali
A
Luciano
Mark
M
D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D010235:Paraganglioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery