A soluble-polymer system for the asymmetric transfer hydrogenation of ketones.
The appropriate combination of methacrylate polymers permits the synthesis of a soluble polymer for use in ruthenium(II)-catalyzed asymmetric transfer hydrogenation reactions. Using a 7:3 copolymer of a poly(ethylene glycol) ester and a hydroxyethyl ester, a derived ruthenium(II)/norephedrine complex catalyses reduction of acetophenone in up to 95% yield and 81% ee.
Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Stephanie
S
Bastin
Richard J
RJ
Eaves
Christopher W
CW
Edwards
Osamu
O
Ichihara
Mark
M
Whittaker
Martin
M
Wills