The association between environmental lead exposure and bone density in children.
Osteoporosis is a decrease in bone mineral density (BMD) that predisposes individuals to fractures. Although an elderly affliction, a predisposition may develop during adolescence if a sufficient peak BMD is not achieved. Rat studies have found that lead exposure is associated with decreased BMD. However, human studies are limited. We hypothesized that the BMD of children with high lead exposure would be lower than the BMD of children with low lead exposure. We collected data on 35 subjects; 16 had low cumulative lead exposure (mean, 6.5 microg/dL), and 19 had high exposure (mean, 23.6 micro g/dL). All were African American; there was no difference between the groups by sex, age, body mass index, socioeconomic status, physical activity, or calcium intake. Significant differences in BMD between low and high cumulative lead exposure were noted in the head (1.589 vs. 1.721 g/cm2), third lumbar vertebra (0.761 vs. 0.819 g/cm2), and fourth lumbar vertebra (0.712 vs. 0.789 g/cm2). Contrary to our hypothesis, subjects with high lead exposure had a significantly higher BMD than did subjects with low lead exposure. This may reflect a true phenomenon because lead exposure has been reported to accelerate bony maturation by inhibiting the effects of parathyroid hormone-related peptide. Accelerated maturation of bone may ultimately result in a lower peak BMD being achieved in young adulthood, thus predisposing to osteoporosis in later life. Future studies need to investigate this proposed model.
Department of Pediatrics, University of Rochester Medical Center, and Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA. James.Campbell@ViaHealth.org
James R
JR
Campbell
Randy N
RN
Rosier
Leonore
L
Novotny
J Edward
JE
Puzas
D001741:Black or African American; D015519:Bone Density; D001846:Bone Development / Q000187:drug effects; D016022:Case-Control Studies; D002648:Child; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000150:complications*; D008297:Male; D010024:Osteoporosis / Q000209:etiology*; D044162:Parathyroid Hormone-Related Protein / Q000494:pharmacology; D012307:Risk Factors
D044162:Parathyroid Hormone-Related Protein; D007854:Lead