Modified technique of ureteroureterostomy in rat kidney transplantation.
Different strain combinations of rats are available to study immunological and transplant-related problems in the models of kidney transplantation. Although numerous modifications of surgical techniques for ureteric reconstruction are evaluated in order to reduce complications and to extend long-term survival, ureteric complications still occur frequently, especially when the difference in diameter of both donor and host ureters is disproportionate. Instead of using the current nonsplinted ureteroureterostomy (method A), a versatile and rapid technical modification (method B) was developed to perform reconstruction of ureters with disproportionate diameters. The overall incidence of ureteric complications was 80% (8/10) using method A, whereas this rate was significantly reduced to 15% (3/20) using method B (P < 0.001). Our modification proves the feasibility of nonsplinted ureteroureterostomy in a technical, highly demanding rat model of kidney transplantation with an acceptable rate of ureteric complication, considering the disproportionate difference in diameter between the host and donor ureters.
Pietsch
Alexander
A
Division of Organ Transplantation, University of Wisconsin Hospital and Clinics, Madison, WI 53792-3236, USA.
Nett
Philipp C
PC
Sollinger
Hans W
HW
Hullett
Debra A
DA
D000714:Anastomosis, Surgical; D000818:Animals; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D023421:Models, Animal; D051381:Rats; D014513:Ureter / Q000601:surgery*; D014519:Ureterostomy / Q000379:methods*