[Effect of endoscopic sinus surgery on asthmatic patients with chronic sinusitis and nasal polyps].
OBJECTIVE
To explore the effect of endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis and asthma.


METHODS
Forty-two patients with asthma who underwent ESS and control group were investigated. Interleukin-4 (IL-4), interferon-gamma (IFN-gamma), soluble interleukin-2 receptor (sIL-2R) and soluble CD23 (sCD23) levels in culture supernatant of peripheral blood mononuclear cell (PBMC) were determined by enzyme-linked immunosorbent assay (ELISA).


RESULTS
Of these 42 patients 32 (76%), their asthma was relieved greatly after ESS comparing with that before ESS. 14 of 21 patients (67%) taken regular medication for asthma before ESS reported that less medicine was used after operation.


CONCLUSIONS
This study demonstrates that ESS has a favorable effect on asthma in patients with symptomatic chronic sinusitis.
Hong
Su-ling
SL
Department of Otorhinolaryngology, The First Hospital, Chongqing Medical University, Chongqing 400016, China. yangyucheng74@hotmail.com
Huang
Jiang-ju
JJ
Yang
Yu-cheng
YC
Kang
Hou-yong
HY
Wang
Yi-qin
YQ
Sun
Rong
R
Qian
Di
D
Dong
Xiao-qin
XQ
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood / Q000150:complications / Q000601:surgery*; D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000601:surgery*; D015375:Receptors, Interleukin-2 / Q000097:blood; D012852:Sinusitis / Q000150:complications / Q000601:surgery*
D015375:Receptors, Interleukin-2; D015847:Interleukin-4; D007371:Interferon-gamma