Antioxidant phenolic and quinonemethide triterpenes from Cheiloclinium cognatum.
The triterpenes, 22beta-hydroxypristimerin and cognatine, were isolated together with the known compounds pristimerin, maytenin, 20alpha-hydroxymaytenin, 22beta-hydroxymaytenin, netzahualcoyol, netzahualcoyondiol and netzahualcoyone from root bark of Cheiloclinium cognatum. The structures of the isolated compounds were elucidated by interpretation of their spectral data, including gHMQC and gHMBC experiments. The isolates were investigated for their radical scavenging abilities through a spectrophotometric assay involving reduction of 2,2-diphenyl-picryl hydrazyl (DPPH).
Departamento de Química, Universidade Estadual de Mato Grosso do Sul, CP 351, 79804-970 Dourados, MS, Brazil.
Alex Haroldo
AH
Jeller
Dulce Helena Siqueira
DH
Silva
Luciano Morais
LM
Lião
Vanderlan da Silva
Vda S
Bolzani
Maysa
M
Furlan
D000975:Antioxidants / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D016166:Free Radical Scavengers / Q000737:chemistry; D031320:Hippocrateaceae / Q000737:chemistry* / Q000145:classification; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
C494170:22 beta-hydroxypristimerin; D000975:Antioxidants; D016166:Free Radical Scavengers; D014315:Triterpenes; C494167:cognatine