Computational studies of membrane channels.
The determination of the structure of several members of the K+ channel and aquaporin family represents a unique opportunity to explain the mechanism of these biomolecular systems. With their ability to go beyond static structures, molecular dynamics simulations offer a unique route for relating functional properties to membrane channel structure. The recent progress in this area is reviewed.
Roux
Benoit
B
Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA. benoit.roux@med.cornell.edu
Schulten
Klaus
K
D000818:Animals; D020346:Aquaporins / Q000737:chemistry*; D006801:Humans; D007473:Ion Channels / Q000737:chemistry*; D008968:Molecular Conformation; D012984:Software; D013598:Systems Theory
D020346:Aquaporins; D007473:Ion Channels