Benzoic acid inhibitors of influenza virus neuraminidase.
A strategy was developed to design non-carbohydrate inhibitors of influenza virus neuraminidase. Using an iterative cycle of modeling, synthesis, biological testing and X-ray crystallography structure determination, a series of inhibitors based on benzoic acid were produced. The refined structures of three compounds complexed with neuraminidase are reported. The results demonstrate the success of this structure-based drug-design strategy.
Luo
M
M
Center for Macromolecular Crystallography, Department of Microbiology, University of Alabama at Birmingham, 35294, USA.
Jedrzejas
M J
MJ
Singh
S
S
White
C L
CL
Brouillette
W J
WJ
Air
G M
GM
Laver
W G
WG