The STATs in cell stress-type responses.
In the early 1990's, a new cell signaling pathway was described. This new paradigm, now known as the JAK/STAT pathway, has been extensively investigated in immune-type cells in response to interferons and interleukins. However, recent evidence suggests that the JAK/STAT pathway also mediates diverse cellular responses to various forms of biological stress including hypoxia/reperfusion, endotoxin, ultraviolet light, and hyperosmolarity. The current literature describing the JAK/STAT pathway's role in cellular stress responses has been reviewed herein, but it is clear that our knowledge in this area is far from complete.
The Department of Medicine, St, Vincent's Hospital, The University of Melbourne, Melbourne, Australia. drew@medstv.unimelb.edu.au
Andrew C
AC
Dudley
David
D
Thomas
James
J
Best
Alicia
A
Jenkins