Variability of natural killer activity during immunotherapy.
In patients with multiple sclerosis, chronic active hepatitis B, and relapsing genital herpes integral parameters of variability in natural killer activity were higher than in donors. In the dynamics of immunotherapy with IFN preparations (chronic active hepatitis B) and IFN inductor ridostine (relapsing genital herpes) these parameters decreased and approached the normal values. The possibility of using variability of natural killer activity for evaluation of cell function and prediction of the efficiency of immunotherapy is discussed.
Laboratory of Cell-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia. cheknev@riem.ru
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D000293:Adolescent; D000328:Adult; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000628:therapy; D006558:Herpes Genitalis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007369:Interferon Inducers / Q000627:therapeutic use; D007372:Interferons / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology / Q000628:therapy
D007369:Interferon Inducers; D007372:Interferons