The influence of 5-year therapy with tibolone on the lipid profile in postmenopausal women with mild hypercholesterolemia.
Our objective was to investigate the effects of 5-year therapy with tibolone on the lipid profile in postmenopausal women with mild hypercholesterolemia (total cholesterol, 241 +/- 7 mg/dl; LDL cholesterol, 153 +/- 9 mg/dl). Eighty-two patients were divided into two groups. Group A (53 women) received 2.5 mg of tibolone per day. Group B (29 women) received no tibolone. Total, low- and high-density lipoprotein cholesterol and lipoprotein(a) were found to be decreased in the tibolone group, by 17.7%, 32%, 15.5% and 12%, respectively (p < 0.01) throughout the 5-year treatment, while triglycerides showed no significant change. The lipid profile in the control group remained at its initial values. Menopausal symptoms disappeared in the treatment group within the first 5 months, whereas they deteriorated in the control group during the first 2 years. Although a few unwanted side-effects on hormone-dependent tissues were observed (including vaginal spotting in 11.3% and febrile hemorrhagic cystic mastopathy in 3.8%) long-term therapy with tibolone seemed to be well tolerated, and appeared to have a beneficial effect on the levels of serum lipids.
IASO Woman's Hospital, Athens, Greece.
S
S
Kalogeropoulos
C
C
Petrogiannopoulos
S
S
Gagos
N
N
Kampas
G
G
Kalogeropoulos
D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D020847:Estrogen Receptor Modulators / Q000627:therapeutic use*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008137:Longitudinal Studies; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use*; D017698:Postmenopause; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D020847:Estrogen Receptor Modulators; D008055:Lipids; D017270:Lipoprotein(a); D009652:Norpregnenes; D014280:Triglycerides; D002784:Cholesterol; C027385:tibolone