Characterisation of a type 2 bovine viral diarrhoea virus isolated from cattle in the UK.
Two genotypes of bovine viral diarrhoea virus (BVDV) are recognised. Type 2 was first recognised when virulent strains caused significant losses among cattle in North America. Subsequently, BVDV type 2 has been found in many other countries, but recent studies have shown that only type 1 BVDV is circulating in the UK herds (sheep and cattle) with type 1a predominating. During routine genotyping of UK BVDV isolates, a type 2 isolate was identified. Phylogenetic analysis of the 5'-untranslated region of the viral genome showed it to be a BVDV type 2a, most similar to a low virulent US strain of BVDV type 2. Antigenic typing with a panel of monoclonal antibodies verified this classification. This is the first confirmed isolation of BVDV type 2 found circulating in the UK.
Wakeley
P R
PR
Veterinary Laboratories Agency-Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK. p.wakeley@vla.defra.gsi.gov.uk
Turner
J L E
JL
Ibata
G
G
King
D P
DP
Sandvik
T
T
Howard
P
P
Drew
T W
TW
D020121:5' Untranslated Regions / Q000737:chemistry / Q000235:genetics; D000818:Animals; D000940:Antigenic Variation / Q000235:genetics; D001483:Base Sequence; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology / Q000821:virology*; D002353:Carrier State / Q000662:veterinary; D002417:Cattle; D030242:Diarrhea Virus 2, Bovine Viral / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D006113:United Kingdom
D020121:5' Untranslated Regions; D012367:RNA, Viral