The effect of cysteine analogues on the excretion of urinary sulphate in the rat following cysteine administration.
A major pathway for the production of sulphate within the mammalian body is known to be via the oxidative degradation of the sulphur moiety within the amino acid, L-cysteine. The ability of two structurally similar sulphur-containing drugs, the anti-rheumatic agent, D-penicillamine, and the mucoactive compound, S-carboxymethyl-L-cysteine, to interfere with this sulphate production was investigated. Co-administration to the male rat of D-penicillamine (p.o.) and S-carboxymethyl-L-cysteine (p.o.) with [35S]-L-cysteine (i.p.) led to a significant decrease in the subsequent urinary elimination of inorganic sulphate whilst having no measurable effect on organic sulphate excretion. The co-administration of L-valine, an amino acid not containing sulphur, had no effect. It is not known where, within the complex sequence of events surrounding the degradation of cysteine to sulphate, that D-penicillamine or S-carboxymethyl-L-cysteine may interact.
Section of Biological Chemistry, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, UK.
E S
ES
Roopnarinsingh
G B
GB
Steventon
R M
RM
Harris
R H
RH
Waring
S C
SC
Mitchell
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000737:chemistry; D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000737:chemistry; D002233:Carbocysteine / Q000008:administration & dosage* / Q000737:chemistry; D003545:Cysteine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008297:Male; D008956:Models, Chemical; D010396:Penicillamine / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013431:Sulfates / Q000652:urine*; D014633:Valine / Q000008:administration & dosage / Q000737:chemistry
D000891:Anti-Infective Agents, Local; D018501:Antirheumatic Agents; D013431:Sulfates; D002233:Carbocysteine; D010396:Penicillamine; D014633:Valine; D003545:Cysteine