A mechanical basis for chromosome function.
We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. kleckner@fas.harvard.edu
Nancy
N
Kleckner
Denise
D
Zickler
Gareth H
GH
Jones
Job
J
Dekker
Ruth
R
Padmore
Jim
J
Henle
John
J
Hutchinson
D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D002875:Chromosomes / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D018744:DNA, Plant / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D008540:Meiosis; D008938:Mitosis; D008954:Models, Biological; D009690:Nucleic Acid Conformation; D013314:Stress, Mechanical; D013997:Time Factors
D002843:Chromatin; D018744:DNA, Plant