Adverse drug reactions in the orofacial region.
A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.
Eastman Dental Institute for Oral Health Care Sciences, University College, University of London, 256 Gray's Inn Road, London WC1X 8LD, UK. scully.c@eastman.ucl.ac.uk
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Scully
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JV
Bagan
D064420:Drug-Related Side Effects and Adverse Reactions; D005157:Facial Pain / Q000139:chemically induced; D005881:Gingiva / Q000187:drug effects*; D006801:Humans; D009059:Mouth Diseases / Q000139:chemically induced*; D009061:Mouth Mucosa / Q000187:drug effects*; D013651:Taste Disorders / Q000139:chemically induced; D014075:Tooth Discoloration / Q000139:chemically induced; D020433:Trigeminal Nerve Diseases / Q000139:chemically induced