Chitosan adsorbents carrying amino acids for selective removal of low density lipoprotein.
Chitosan beads carrying various amino acids (a total of 12 kinds) were synthesized through quite simple procedures for selective removal of low density lipoprotein (LDL). Macroporous chitosan beads were prepared by the phase-inversion method, to which the amino acids were then coupled respectively, via either ethyleneglycol diglycidylether (EGDE) or epichlorohydrin (ECH). Among the amino acids used, in vitro tests proved L-Trp to be the best ligand for binding LDL. The adsorbent, which was prepared by coupling L-Trp to the chitosan beads via EGDE, demonstrated satisfactory adsorption performance for selective removal of LDL in human plasma.
Fu
Guoqi
G
Institute of Polymer Chemistry, The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Nankai University, Tianjin, China. guoqi_fu@sohu.com
Yu
Haofeng
H
Yuan
Zhi
Z
Liu
Bin
B
Shen
Bin
B
He
Binglin
B
D000327:Adsorption; D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism; D048271:Chitosan; D004811:Epichlorohydrin / Q000737:chemistry; D004853:Epoxy Resins / Q000737:chemistry; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D013997:Time Factors
D000596:Amino Acids; D004853:Epoxy Resins; D008077:Lipoproteins, LDL; D004811:Epichlorohydrin; D002686:Chitin; C035364:Quetol 651; D048271:Chitosan