Neuronal diseases: small heat shock proteins calm your nerves.
Mutations in HSPB1 and HSPB8, members of the small heat shock protein family, have recently been shown to cause some distal motor neuropathies. Their function in motor neurones is now under scrutiny.
School of Biological and Biomedical Science, South Road Science Site, The University, Durham DH1 3LE, UK.
Ming
M
Der Perng
Roy A
RA
Quinlan
D001692:Biological Transport / Q000502:physiology; D055551:HSP27 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D015417:Hereditary Sensory and Motor Neuropathy / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007382:Intermediate Filaments / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D018832:Molecular Chaperones; D009046:Motor Neurons / Q000378:metabolism*; D009154:Mutation / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism
D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; C413214:HSPB8 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; D017346:Protein Serine-Threonine Kinases