Allergenicity evaluation of Bioban CS-1135 in experimental animals.
An industrial preservative, Bioban CS-1135, was evaluated for its contact allergenicity by means of multiple-dose guinea-pig maximization test and non-radioactive murine local lymph node assay. In the guinea-pig test, an induction dose of 0.5% Bioban CS-1135 sensitized all animals of the group. The dose-response study of the elicitation phase determined a minimum elicitation dose of 5% for positive skin reactions. In the murine assay, Bioban CS-1135 at doses of 10% and more exerted significant effects on lymphoid cell proliferation. Although the data clearly designated Bioban CS-1135 as a skin sensitizer, its relative potency was ranked lowest among skin-sensitizing biocides previously evaluated in this laboratory.
Yamano
Tetsuo
T
Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan. tetsuo.yamano@iphes.city.osaka.jp
Shimizu
Mitsuru
M
Noda
Tsutomu
T
D000485:Allergens; D000818:Animals; D000890:Anti-Infective Agents / Q000276:immunology*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology; D004306:Dose-Response Relationship, Immunologic; D004338:Drug Combinations; D005260:Female; D006168:Guinea Pigs; D023441:Local Lymph Node Assay; D051379:Mice; D008807:Mice, Inbred BALB C; D010080:Oxazoles / Q000276:immunology*
C083031:4,4-Dimethyl-1,3-oxazolidine, 3,4,4-trimethyl-1,3-oxazolidine drug combination; D000485:Allergens; D000890:Anti-Infective Agents; D004338:Drug Combinations; D010080:Oxazoles