[Clinical and neurophysiologic aspects of surgical treatment of pharmacoresistant forms of epilepsy].
Surgical treatment of pharmacoresistant forms of epilepsy under neurophysiological monitoring is a key problem studied in A.L. Polenov Russian Neurosurgical Institute (Saint-Petersburg). A summary of long-term studies and main stages of surgical treatment development are presented. The indications and contra-indications, along with basic neurophysiologic strategic and tactic arguments of open and stereotaxic treatment of focal and generalized epilepsy based on neurophysiologic model which determines a role of epileptic focus, epileptic and inhibiting brain systems in spreading and arresting of seizure discharge at each disease stage are formulated. A program of clinico-neurophysiologic monitoring of temporal epilepsy in pre- and intraoperative periods is considered.
V P
VP
Bersnev
T S
TS
Stepanova
Iu V
IuV
Zotov
R D
RD
Kasumov
S L
SL
Iatsuk
K V
KV
Grachev
D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D004351:Drug Resistance; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods*; D011300:Preoperative Care
D000927:Anticonvulsants