[Clinic significance of morphometric study on squamous cell carcinoma of floor of mouth].
OBJECTIVE
The purpose of this study was to investigate the role of cell morphometric factor (FC) and the average density of light in squamous cell carcinomas at the floor of mouth by immunohistochemical method (SABC).


METHODS
The slices made from the paraffin specimens of 28 patients with squamous cell carcinomas at the floor of mouth were stained by the immunohistochemical technique with monoclonal antibody CK10 and CK14. In these stained slices the FC parameters and the average density of light were measured by using an image analysis system.


RESULTS
In primitive tumors, the FC parameters and the average density of light were significantly different between positive and negative lymph nodes metastasis or between different pathological grades (P < 0.05 or < 0.001). The significance was not existed among clinical stages (P > 0.05). The difference of FC expressed in positive and negative lymph nodes metastasis were significant (P < 0.05 or < 0.001).


CONCLUSIONS
The cell morphometric factor (FC) parameters and the average density of light of CK10 and CK14 could be used as a biological guideline to evaluate the clinically infiltrative and metastasic potential of squamous cell carcinoma at the floor of mouth.
Zhao
Hong-wei
HW
Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Li
Long-jiang
LJ
Xie
Wen-yang
WY
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D009333:Neck
D014408:Biomarkers, Tumor