Indomethacin attenuates hyperthermia produced by anterior coronal lateral hypothalamic knife cuts.
Electrolytic lesions of the lateral hypothalamus (LH) and coronal knife cuts of fibers anterior to the LH produce an elevation in core body temperature, or hyperthermia. Prostaglandin has been shown to mediate hyperthermia produced by electrolytic LH lesions. The present study characterizes the time course and the role of prostaglandin in mediating knife-cut-induced hyperthermia. Results show that the prostaglandin synthesis inhibitor indomethacin significantly attenuates hyperthermia produced by the knife cuts, suggesting that prostaglandin is involved in mediating this temperature increase. A disruption of axonal fibers that project from the LH to the preoptic area is postulated to be responsible for the temperature increase. There was no effect of knife cuts on food intake and body weight loss, which were also measured, suggesting that this fiber system is not involved in feeding behavior.
Department of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095-1563, USA. vrau@ucla.edu
Vinuta
V
Rau
Carlos V
CV
Grijalva
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects; D001930:Brain Injuries / Q000150:complications*; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D007026:Hypothalamic Area, Lateral / Q000293:injuries* / Q000503:physiopathology; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin