The potential role of community-based registries to complement the limited applicability of clinical trial results to the community setting: heart failure as an example.
BACKGROUND
Clinical trials do not represent community settings, making widespread implementation of evidence-based medicine problematic. New heart failure treatments are an example, as results comparable to those of clinical trials have not been observed in the community. Alternatives to clinical trials could provide useful complementary information.


OBJECTIVE
To review the clinical trials and community experiences in heart failure management by searching Pubmed with key words "observational studies," "clinical trials," and "heart failure," to present the preliminary results of a community-based heart failure registry as a complementary database, and to assess the potential value and limitations of the registry approach.


RESULTS
Recent advances in the treatment of heart failure led to guidelines using clinical trial evidence as the rationale for transferring newer therapeutic technologies to the community practice setting. Implementation of such guidelines is slow, reflecting concerns over applicability of clinical trial results to the community setting. A community-based registry of beta-blocker treatment for heart failure showed outcomes comparable to those of clinical trials, despite significant differences between physicians and their patients in these settings.


CONCLUSIONS
Registries can complement clinical trials to expedite technology transfer to the community setting.
Franciosa
Joseph A
JA
Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10024, USA. josephafranciosa@aol.com
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003153:Community Health Services / Q000458:organization & administration*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D012042:Registries; D014481:United States
D000319:Adrenergic beta-Antagonists