Experimental validation of an affinity energy distribution calculated with the expectation maximization method.
The difference between the average energies of the high-energy modes of the adsorption energy distributions of (S)-alprenolol and (R)-alprenolol on a chiral stationary phase calculated by the expectation maximization method agree well with the difference between the adsorption energies of these two compounds measured by isothermal titration calorimetry.
Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996-1600, USA.
Gustaf
G
Götmar
Georges
G
Guiochon