Effect of parenteral and enteral nutrition combined with octreotide on pancreatic exocrine secretion of patients with pancreatic fistula.
OBJECTIVE
To evaluate the effect of parenteral and enteral nutrition combined with octreotide on pancreatic exocrine secretion of the patients with pancreatic fistula.


METHODS
Pancreatic juice, drained directly from the pancreatic fistula, was collected, and the volume, protein, amylase, HCO(3)(-), K(+), Na(+) and Cl(-) were determined on d 1, 4 and 7 before and after 7-d treatment with octreotide, respectively.


RESULTS
No differences in exocrine pancreatic secretion were observed during the enteral and parenteral nutrition period (t = 2.03, P > 0.05); there were significant decreases in pancreatic juice secretion volume, protein, amylase, HCO(3)(-), K(+), Na(+) and Cl(-) after parenteral and enteral nutrition combined with octreotide compared with octreotide pretreatment (t = 4.14, P < 0.05).


CONCLUSIONS
There is no stimulatory effect on the pancreatic secretion by intrajejunal nutrition and parenteral nutrition. Octreotide is effective on the reduction of pancreatic fistula output.
Department of Surgery, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China. jiaqc@online.sh.cn
Huan-Long
HL
Qin
Zhen-Dong
ZD
Su
Yang
Y
Zou
You-Ben
YB
Fan
D000328:Adult; D000368:Aged; D000681:Amylases / Q000032:analysis; D001639:Bicarbonates / Q000032:analysis; D002712:Chlorides / Q000032:analysis; D003131:Combined Modality Therapy; D004750:Enteral Nutrition; D005260:Female; D005402:Fistula / Q000503:physiopathology / Q000628:therapy*; D005768:Gastrointestinal Hormones / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010182:Pancreatic Diseases / Q000503:physiopathology / Q000628:therapy*; D010189:Pancreatic Juice / Q000378:metabolism; D010288:Parenteral Nutrition; D011188:Potassium / Q000032:analysis; D012964:Sodium / Q000032:analysis
D001639:Bicarbonates; D002712:Chlorides; D005768:Gastrointestinal Hormones; D012964:Sodium; D000681:Amylases; D015282:Octreotide; D011188:Potassium