Bombyx mori prothoracicostatic peptide inhibits ecdysteroidogenesis in vivo.
Bombyx prothoracicostatic peptide (Bom-PTSP) is a brain neuropeptide that has recently been reported to have in vitro inhibitory activity to prothoracicotropic hormone (PTTH)-stimulated ecdysteroid biosynthesis in the prothoracic gland of the silkworm, Bombyx mori. In the present report, Bom-PTSP has been shown to significantly decrease hemolymph ecdysteroid titer in the fifth instar larvae when Bom-PTSP was injected into the fifth instar day 8 silkworm larvae, resulting in significant delay in spinning behavior. This is the first evidence that Bom-PTSP inhibits in vivo ecdysteroidogenesis in the silkworm.
Institute of Nuclear-Agricultural Science, Zhejiang University, Zhejiang, China.
Xin
X
Liu
Yoshiaki
Y
Tanaka
Qisheng
Q
Song
Bujin
B
Xu
Yuejin
Y
Hua
D000818:Animals; D012831:Bombyx / Q000254:growth & development / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D026461:Ecdysteroids / Q000096:biosynthesis*; D006458:Hemolymph / Q000502:physiology; D007814:Larva; D008297:Male; D008675:Metamorphosis, Biological; D009479:Neuropeptides / Q000494:pharmacology / Q000502:physiology*; D013997:Time Factors
D026461:Ecdysteroids; D009479:Neuropeptides; C400522:alanyl-tryptophyl-glutaminyl-aspartyl-leucyl-asparagyl-seryl-alanyl-tryptophanamide