[Pathological observations of Fructus Schisandrae polysaccharide on anti-tumor effects in S180-bearing mice].
OBJECTIVE
To study the effects of Fructus Schisandrae Polysaccharide (FSP) on anti-tumor in S180-bearing mice.


METHODS
The transplantable carcinosarcoma model was established in S180-bearing mice by subcutaneous implantation. Tumor size and histopathological changes were observed under electron microscopy by HE staining after 8 days treatment.


RESULTS
Morphological changes showed that slight cataplasia and apoptosis were induced by high concentration FSP, as well as the numbers of inflammatory cells in tumor were increased and tumor cells in infiltration areas around tumor cataplasised partly. These suggested that high concentration FSP can inhibit tumor growth lightly. In addition, high concentration FSP combined with cyclophosphamide can promote the effect of anti-tumor.


CONCLUSIONS
FSP can inhibit tumor growth, this effect may be correlated with apoptosis and the activation of immunocytes, but not depend on killing tumor cells directly. In addition, high concentration FSP combined with cyclophosphamide can promote the capacity on anti-tumor in S180-bearing mice.
Fujian College of Traditional Chinese Medicine, Fuzhou 350003.
Ling
L
Huang
Ling
L
Chen
Zhenlin
Z
Zhang
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005638:Fruit / Q000737:chemistry; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010946:Plants, Medicinal / Q000737:chemistry*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000473:pathology*; D032141:Schisandra / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D011134:Polysaccharides; D003520:Cyclophosphamide