In vivo acquisition of high-level resistance to imipenem in Escherichia coli.
Four clonally related Escherichia coli strains were isolated successively from bile duct of a girl suffering from sclerosing cholangitis. One of them, selected after an imipenem-containing regimen, was resistant to carbapenems and to broad-spectrum cephalosporins due to a plasmid-mediated cephalosporinase, CMY-2, and the lack of outer membrane proteins OmpF and OmpC.
Poirel
Laurent
L
Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 Rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France.
Héritier
Claire
C
Spicq
Colette
C
Nordmann
Patrice
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods
D000900:Anti-Bacterial Agents; D017931:DNA Primers; D015378:Imipenem