MT1-MMP: an enzyme with multidimensional regulation.
The activity of membrane-type 1 matrix metalloproteinase (MT1-MMP) is a double-edged sword--it is crucial for both physiological processes and disease progression. MT1-MMP modifies various cellular functions and it is, sthus, regulated precisely as a proteinase and as a membrane protein. Recent studies have further revealed that the function of MT1-MMP is modified and regulated by O-glycosylation, interaction with CD44, internalization and recycling. Such multidimensional mechanisms enable MT1-MMP to be regulated spatially and temporally, and are essential for its proper functioning on the cell surface.
Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, UK.
Yoshifumi
Y
Itoh
Motoharu
M
Seiki
D002462:Cell Membrane / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D018960:Hyaluronan Receptors / Q000502:physiology; D053504:Matrix Metalloproteinases, Membrane-Associated; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism*
D018960:Hyaluronan Receptors; D008565:Membrane Proteins; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases