Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia.
Most antipsychotic drugs act on the forebrain by blocking dopamine receptors. In rodents, the M5 muscarinic receptor (CHRM5) is important for prolonged dopamine release. We typed polymorphisms in CHRM5 and alpha7-nicotinic receptor (CHRNA7) genes on 15q13 in 82 Canadian families having at least 1 schizophrenic patient. Using the Family-Based Association Test, we performed haplotype analysis of the 2 loci and found biased transmission in schizophrenia (z = -2.651, p = 0.008). In the families tested, the 2 cholinergic genes interacted to affect schizophrenia in combination, while neither was sufficiently alone to confer susceptibility. Our present study provided the first line of direct evidence suggesting that the CHRM5 gene combined with the CHRNA7 gene may be linked to schizophrenia.
De Luca
Vincenzo
V
Department of Psychiatry, Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont., Canada.
Wang
Haoran
H
Squassina
Alessio
A
Wong
Greg W H
GW
Yeomans
John
J
Kennedy
James L
JL
D000483:Alleles; D002170:Canada / Q000453:epidemiology; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004912:Erythrocytes / Q000737:chemistry; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D043642:Receptor, Muscarinic M5 / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000235:genetics*; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D064569:alpha7 Nicotinic Acetylcholine Receptor
C579167:Chrna7 protein, human; D043642:Receptor, Muscarinic M5; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor; D004247:DNA