Treatment of eosinophilic meningitis with a combination of albendazole and corticosteroid.
To study the efficacy of the combination of albendazole and prednisolone for the treatment of eosinophilic meningitis, we conducted a pilot study among Thai patients with eosinophilic meningitis. Patients were given a 2-week course of prednisolone, 60 mg/day and albendazole, 15 mg/kg/ day. The primary observation parameter was the number of patients who still had headache after the 2-week course of treatment. Twenty-six patients were enrolled in the study. There were 3 (11.5%) patients who still had headache after the 2-week course of treatment and the median length of time until complete disappearance of headache was 4 days. Serious side effects were not detected. Treatment for 2 weeks with the combination regimen of albendazole and prednisolone is safe and effective for the treatment of eosinophilic meningitis.
Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Verajit
V
Chotmongkol
Chatchawan
C
Wongjitrat
Kookwan
K
Sawadpanit
Kittisak
K
Sawanyawisuth
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D015766:Albendazole / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D013785:Thailand; D016896:Treatment Outcome
D011239:Prednisolone; D015766:Albendazole