Interferon-gamma and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children.
A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-gamma and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-gamma, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.
University of Colorado School of Medicine and The Children's Hospital (Pediatric Infectious Diseases, Department of Pediatrics), Denver, CO 80218, USA. abzug.mark@tchden.org
Mark J
MJ
Abzug
Thomas J
TJ
Walsh
D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D025141:Drug Resistance, Fungal; D004359:Drug Therapy, Combination; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D009089:Mucor / Q000472:pathogenicity; D009091:Mucormycosis / Q000188:drug therapy* / Q000473:pathology; D008271:Mycetoma / Q000188:drug therapy* / Q000473:pathology; D021681:Scedosporium / Q000472:pathogenicity; D016896:Treatment Outcome
D000998:Antiviral Agents; D016179:Granulocyte Colony-Stimulating Factor; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor