Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.
Biel
Markus
M
University of Leipzig, Institute of Organic Chemistry, Johannisallee 29, 04103 Leipzig, Germany.
Kretsovali
Androniki
A
Karatzali
Efthymia
E
Papamatheakis
Joseph
J
Giannis
Athanassios
A
D015107:4-Butyrolactone / Q000737:chemistry / Q000494:pharmacology; D000123:Acetyltransferases / Q000037:antagonists & inhibitors* / Q000235:genetics*; D000818:Animals; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism; D051548:Histone Acetyltransferases; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic
D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D015107:4-Butyrolactone