Advances in the early detection of Alzheimer's disease.
The combination of an aging population and the promise, possibly in the near future, of disease-modifying therapies have made the characterization of the early stages of Alzheimer's disease (AD) a topic of major research interest. In this article we review recent progress in our understanding of the evolution of early AD with particular reference to the symptomatic pre-dementia stage designated 'mild cognitive impairment', emphasizing work on the early cognitive profile and associated neuroimaging studies.
Nestor
Peter J
PJ
University Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.
Scheltens
Philip
P
Hodges
John R
JR
D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D015415:Biomarkers; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology; D003704:Dementia / Q000209:etiology / Q000473:pathology; D003952:Diagnostic Imaging; D018450:Disease Progression; D042241:Early Diagnosis; D006801:Humans; D009483:Neuropsychological Tests
D015415:Biomarkers