Procarbacine radiolysis and experiments in vitro.
Steady-state radiolysis of aqueous procarbazine (PC) was studied in air-free, aerated and solutions saturated with N2O. The corresponding Gi(-PC)-values obtained at pH=7.4 were: 2.85, 5.60 and 3.45, respectively. The investigations in vitro, using E. coli (AB 1157) as a model for living systems, demonstrated that PC acts as a cytostatic in air-free as well as in aerated media. However, it shows radiation protecting ability in the presence of N2O, where OH-radicals are the predominant reactants. Similar results were observed at pH=6.2. The experimental data contribute to a better understanding of the many-sided and frequently contradictory behavior of PC.
Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, c/o The University of Vienna, UZA II, A-1090 Wien, Austria.
Alexandra
A
Delipetar-Grudl
Nikola
N
Getoff
D000388:Air; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D009609:Nitrous Oxide / Q000737:chemistry; D011344:Procarbazine / Q000737:chemistry* / Q000494:pharmacology; D011675:Pulse Radiolysis; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D012996:Solutions
D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents; D012996:Solutions; D011344:Procarbazine; D009609:Nitrous Oxide