Mapping key elements of a protein motif.
In this issue of Chemistry & Biology, Weiss and colleagues use phage display to map residues in the engrailed homeodomain that influence DNA recognition. Their shotgun scanning data provides surprising new insights into the importance of regions outside the recognition helix and N-terminal arm for DNA binding.
Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Scot A
SA
Wolfe
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D004247:DNA / Q000378:metabolism; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D011506:Proteins; D004247:DNA