Novel antimalarial compounds isolated in a survey of self-medicative behavior of wild chimpanzees in Uganda.
Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-directed fractionation provided two new limonoids, trichirubines A and B. A greater understanding of the role of secondary compounds in the primate diet may be helpful in recovering naturally occurring compounds of medicinal significance for human medicine.
Krief
Sabrina
S
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France.
Martin
Marie-Thérèse
MT
Grellier
Philippe
P
Kasenene
John
J
Sévenet
Thierry
T
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001522:Behavior, Animal / Q000502:physiology*; D001681:Biological Assay; D002852:Chromatography, Ion Exchange; D003625:Data Collection; D004032:Diet; D004351:Drug Resistance; D036701:Limonins / Q000494:pharmacology*; D029582:Meliaceae; D002679:Pan troglodytes / Q000502:physiology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D012651:Self Medication / Q000523:psychology*; D014454:Uganda
D000962:Antimalarials; D036701:Limonins; D010936:Plant Extracts; C490940:trichirubine A; C490941:trichirubine B