Occurrence of t(8;22)(q24.1;q11.2) involving the MYC locus in a case of pediatric acute lymphoblastic leukemia with a precursor B cell immunophenotype.
The authors describe a child with clinical presentation of acute leukemia and an immunophenotype consistent with precursor B-cell acute lymphoblastic leukemia. However, the lymphoblasts had atypical L3 features and the chromosome rearrangement t(8;22)(q24.1;q11.2) involving the MYC locus. The cytogenetic features in this patient were characteristic of mature B/Burkitt leukemia and led to modulation of therapy. This case highlights the need for timely cytogenetic and molecular studies in the diagnosis of acute leukemia.
Gupta
Abha A
AA
Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada. abha.gupta@sickkids.ca
Grant
Ronald
R
Shago
Mary
M
Abdelhaleem
Mohamed
M
D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002648:Child; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D014178:Translocation, Genetic