Rodent models of experimental autoimmune uveitis.
The model of experimental autoimmune uveitis (EAU) in mice and in rats is described. EAU targets immunologically privileged retinal antigens and serves as a model of autoimmune uveitis in humans as well as a model for autoimmunity in a more general sense. EAU is a well-characterized, robust, and reproducible model that is easily followed and quantitated. It is inducible with synthetic peptides derived from retinal autoantigens in commonly available strains of rats and mice. The ability to induce EAU in various gene-manipulated, including HLA-transgenic, mouse strains makes the EAU model suitable for the study of basic mechanisms as well as in clinically relevant interventions.
Agarwal
Rajeev K
RK
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Caspi
Rachel R
RR
D019264:Adoptive Transfer; D000595:Amino Acid Sequence; D000818:Animals; D019393:Arrestin / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D001324:Autoantigens / Q000008:administration & dosage / Q000235:genetics; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D002417:Cattle; D004195:Disease Models, Animal; D005136:Eye Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D012177:Retinol-Binding Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014605:Uveitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D014611:Vaccination; D000099214:Retinol-Binding Proteins, Interstitial
D019393:Arrestin; D001324:Autoantigens; D005136:Eye Proteins; D010446:Peptide Fragments; D012177:Retinol-Binding Proteins; D000099214:Retinol-Binding Proteins, Interstitial