Metabolic compartmentation in African trypanosomes.
Differences between host and parasite energy metabolism are eagerly sought after as potential targets for antiparasite chemotherapy. In Kinetoplastia, the first seven steps of glycolysis are compartmented inside glycosomes, organelles that are related to the peroxisomes of higher eukaryotes. This arrangement is unique in the living world. In this review, Christine Clayton and Paul Michels discuss the implications of this unusual metabolic compartmentation for the regulation of trypanosome energy metabolism, and describe how an adequate supply of energy is maintained in different species and life cycle stages.
Zentrum für Molekulare Biologie, Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. cclayton@sun0.urz.uni-heidelberg.de
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