Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis.
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.
Monzote Fidalgo
Lianet
L
Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de la Habana, Cuba. monzote@ipk.sld.cu
Montalvo Alvarez
Ana Margarita
AM
Geigel
Lisset Fonseca
LF
Pérez Pineiro
Rolando
R
Suárez Navarro
Margarita
M
Rodríguez Cabrera
Hortensia
H
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007892:Leishmania braziliensis / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D021261:Parasitic Sensitivity Tests; D013829:Thiadiazines / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D013829:Thiadiazines