Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population.
We conducted a case-control association study of the monocyte chemoattractant protein-1 (MCP1) gene -2518 polymorphism in 90 patients with major depressive disorder. Genotyping was performed by polymerase chain reaction methods. We found significant differences in genotype and allele frequencies. The present study suggests that this polymorphism may confer a susceptibility to major depressive disorder in the Korean population.
Department of Psychiatry, Kangnam St. Mary's Hospital, Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Republic of Korea.
Chi-Un
CU
Pae
Hye-Sook
HS
Yu
Tae-Suk
TS
Kim
Chang-Uk
CU
Lee
Soo-Jung
SJ
Lee
Tae-Youn
TY
Jun
Chul
C
Lee
Alessandro
A
Serretti
In-Ho
IH
Paik
D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*
D018932:Chemokine CCL2; D017931:DNA Primers