Neutrophil function in the healing wound: adding insult to injury?
Cells of the innate immune system, including neutrophils and macrophages, are a highly visible component of normal wound healing in adult mammals. The role of inflammatory cells in the healing wound has been widely investigated, and evidence for both positive and negative influences exists. Several recent investigations support the emerging paradigm that robust inflammation is detrimental to wound closure. This developing information suggests that the functional role of inflammatory cells in wound healing must be reevaluated.
Dovi
Julia V
JV
Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Szpaderska
Anna M
AM
DiPietro
Luisa A
LA
D000818:Animals; D049109:Cell Proliferation; D004847:Epithelial Cells; D006801:Humans; D007107:Immune System / Q000502:physiology; D007249:Inflammation; D008264:Macrophages / Q000378:metabolism; D009504:Neutrophils / Q000502:physiology*; D014945:Wound Healing