Absorption and digestion of phagocytized objects by mononuclear phagocytes during rheumatoid arthritis.
Radioisotope study of mononuclear phagocytes from patients with rheumatoid arthritis showed impaired ingestion of bacteria in the presence of pronounced digestive activity. Excessive accumulation methylumbelliferyl phosphate beta-glucuronide (product of hydrolysis catalyzed by glucuronidase released from cells) into the incubation medium was observed. This was probably related to the predominance of extracellular digestion.
State Medical Academy, Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Sciences, Kazan, Russia. bren@dionis.kfti.knc.ru
M I
MI
Arleevskaya
A I
AI
Zabotin
D G
DG
Khaliullina
A P
AP
Tsibulkin
D001172:Arthritis, Rheumatoid / Q000201:enzymology / Q000503:physiopathology*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008247:Lysosomes / Q000201:enzymology; D010586:Phagocytes / Q000201:enzymology / Q000502:physiology; D010587:Phagocytosis
D005966:Glucuronidase