Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides.
Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of aryl- and heteroaryl chlorides with potassium aryl- and heteroaryltrifluoroborates have been accomplished with the supporting ligand S-Phos in good to excellent yield. Hindered biaryls and substrates containing a variety of functional groups can be prepared. Suzuki-Miyaura couplings of a 3-pyridyl boron-based nucleophile with aryl- and heteroaryl chlorides proceed in good to very good yield. [reaction: see text]
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Timothy E
TE
Barder
Stephen L
SL
Buchwald
D001881:Borates / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D008024:Ligands; D010165:Palladium / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry*
D001881:Borates; D006571:Heterocyclic Compounds; D006843:Hydrocarbons, Chlorinated; D008024:Ligands; D010165:Palladium; D011188:Potassium