Susceptibility of Chlamydia trachomatis to excipients commonly used in topical microbicide formulations.
Commonly used "inactive" pharmaceutical excipients were tested in a previously developed minimum cidal concentration assay to assess their ability to kill Chlamydia trachomatis topically. Sixteen excipients were evaluated in these studies under various conditions. A range of activities was found among the excipients that could be tested in our assay system.
Lampe
M F
MF
Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA. lampe@u.washington.edu
Rohan
L C
LC
Skinner
M C
MC
Stamm
W E
WE
D000891:Anti-Infective Agents, Local / Q000737:chemistry* / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D002692:Chlamydia trachomatis / Q000187:drug effects*; D005079:Excipients / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology
D000891:Anti-Infective Agents, Local; D005079:Excipients; D011310:Preservatives, Pharmaceutical