Global gene expression profiling of human endometrial receptivity.
Scientific knowledge on the molecular changes that occur during the window of implantation is fundamental for the understanding of human reproduction. To gain a global molecular understanding of human endometrial receptivity, we have compared gene expression profiles of pre-receptive (day LH + 2) versus receptive (LH + 7) in well characterized human endometrial biopsies. The samples were analyzed using the Affymetrix HG-95A array, a high density oligonucleotide microarray comprising more than 12,000 genes. In this work, we present part of our results and a comparison with similar works published in the literature. Identified genes include not only genes previously documented to be involved in implantation but also genes for which a role in endometrial receptivity, or even endometrial expression, has not been previously described. Collectively, these studies identify new candidate markers that may be used to diagnose unequivocally the receptive endometrium.
Instituto Valenciano de Infertilidad (IVI), Plaza de la Policía Local, 3, 46015 Valencia, Spain.
José A
JA
Horcajadas
Anne
A
Riesewijk
Julio
J
Martín
Ana
A
Cervero
Sietse
S
Mosselman
Antonio
A
Pellicer
Carlos
C
Simón
D004717:Endometrium / Q000502:physiology*; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D017403:In Situ Hybridization; D008597:Menstrual Cycle / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D025341:Principal Component Analysis