Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.
Liver-intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade (P = 0.015), lymphatic invasion (P = 0.033), lymph node metastasis (P = 0.015), and an advanced pTNM stage (P = 0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.
Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Masaaki
M
Takamura
Takafumi
T
Ichida
Yasunobu
Y
Matsuda
Masaaki
M
Kobayashi
Satoshi
S
Yamagiwa
Takuya
T
Genda
Kazuhiko
K
Shioji
Satoru
S
Hashimoto
Minoru
M
Nomoto
Katsuyoshi
K
Hatakeyama
Yoichi
Y
Ajioka
Michiie
M
Sakamoto
Setsuo
S
Hirohashi
Yutaka
Y
Aoyagi
D000368:Aged; D000911:Antibodies, Monoclonal; D015820:Cadherins; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000096:biosynthesis*; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D026901:Membrane Transport Proteins; D008875:Middle Aged; D010641:Phenotype
D000911:Antibodies, Monoclonal; C490584:CDH17 protein, human; D015820:Cadherins; D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C067802:intestinal peptide-proton cotransporter