Operative revision of non-functioning filtering blebs with 5-fluorouracil to regain intraocular pressure control.
OBJECTIVE
To determine the efficacy of extensive microsurgical needling revision of failed filtering blebs followed by serial 5-fluorouracil subconjunctival injections.


METHODS
Thirty-six eyes of 34 consecutive patients with progressive open-angle glaucoma refractory to topical therapy submitted to needling revision as a major procedure. All patients required multiple antiglaucoma medications preoperatively, and had completely flat or densely encapsulated filtering blebs. All patients underwent elaborate needling revision (limbus to superior rectus >8 mm diameter, >3 mm elevation, entry-site sutured with 8-0 vicryl and bleb reformed via paracentesis with viscoelastic) in the operating room, followed by serial 5-fluorouracil. The patients were followed for up to 6 months postoperatively. The main outcome measures were intraocular pressure (IOP) and the number of antiglaucoma medications used.


RESULTS
Thirty-one eyes (86%) maintained mean IOP below 15 mmHg postneedling without medication. Overall the mean IOP postneedling was >9 mmHg lower than medicated preoperative levels (P < 0.0001). IOP reduction in encapsulated blebs was marginally superior to that in flat blebs.


CONCLUSIONS
Extensive needling revision in the operating room is safe, straightforward, and produces reproducible restoration of filtering function.
Department of Ophthalmology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA.
Gianmarco
G
Paris
Ming
M
Zhao
William E
WE
Sponsel
D000328:Adult; D000368:Aged; D000963:Antimetabolites / Q000008:administration & dosage*; D003228:Conjunctiva / Q000187:drug effects* / Q000601:surgery*; D005260:Female; D018463:Filtering Surgery / Q000379:methods*; D005472:Fluorouracil / Q000008:administration & dosage*; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009339:Needles; D012086:Reoperation
D000963:Antimetabolites; D005472:Fluorouracil