A new class of chiral pyrrolidine-pyridine conjugate base catalysts for use in asymmetric Michael addition reactions.
Direct catalytic asymmetric Michael addition reactions of ketones to nitroolefins using newly developed chiral pyrrolidine-pyridine conjugate bases as catalysts are described. The desired 1,4-adducts are obtained in excellent yields with high enantio- and diastereoselectivities.
Laboratory of Natural Products Synthesis, Faculty of Science, Kochi University, Akebono-cho, Kochi 780-8520, Japan.
Takaaki
T
Ishii
Shingo
S
Fujioka
Yusuke
Y
Sekiguchi
Hiyoshizo
H
Kotsuki