Conjunctival hyperemia associated with bimatoprost use: a histopathologic study.
OBJECTIVE
To evaluate histopathologic signs of conjunctival inflammation in patients with conjunctival hyperemia induced by bimatoprost treatment.


METHODS
Prospective interventional study.


METHODS
The study included 15 eyes of 15 patients scheduled for cataract surgery. Patients in the treatment group (n = 9) exhibited trace to moderate conjunctival hyperemia when treated with bimatoprost 0.03% every day for 15 to 30 days before surgery. The control group (n = 6) included untreated patients with no ocular disease other than cataract. Conjunctival biopsies were obtained for histologic evaluation with light microscopy.


RESULTS
Vascular congestion was observed in biopsies from 7 patients (78%) in the bimatoprost group and 5 patients (83%) in the control group. Signs of inflammation were found in biopsies from 2 patients (22%) in the bimatoprost group and 2 patients (33%) in the control group.


CONCLUSIONS
Histopathologic signs of inflammation were no more frequent in conjunctival specimens from bimatoprost-treated patients with trace to moderate hyperemia than in those from untreated control subjects.
Department of Ophthalmology, Glaucoma Service, University of São Paulo, São Paulo, Brazil.
Bruno C
BC
Leal
Felipe A
FA
Medeiros
Fabrício W
FW
Medeiros
Ruth M
RM
Santo
Remo
R
Susanna
D000577:Amides; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000069580:Bimatoprost; D002387:Cataract Extraction; D003008:Cloprostenol / Q000031:analogs & derivatives; D003228:Conjunctiva / Q000098:blood supply / Q000473:pathology; D003231:Conjunctivitis / Q000139:chemically induced* / Q000473:pathology; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced* / Q000473:pathology; D007429:Intraocular Pressure / Q000187:drug effects; D008055:Lipids / Q000009:adverse effects* / Q000627:therapeutic use; D011446:Prospective Studies
D000577:Amides; D000959:Antihypertensive Agents; D008055:Lipids; D003008:Cloprostenol; D000069580:Bimatoprost