Sonography in the diagnosis of cervical recurrence in patients with differentiated thyroid carcinoma.
OBJECTIVE
To determine the sensitivity of thyroglobulin (Tg), iodine scanning, and sonography in the diagnosis of cervical recurrence of thyroid cancer.


METHODS
This prospective study assessed 81 patients with cervical metastases or extrathyroid invasion at first appearance who underwent clinical examination, scanning, measurement of Tg after thyroxine withdrawal, and sonography about 8 months after thyroidectomy followed by radioiodine treatment. Only patients without distant metastases and without anti-Tg antibodies were included.


RESULTS
Fifty patients showed persistence of the disease in the cervical region, with only 16% of them having had a suspicion on clinical examination, 33 with Tg levels of 2 ng/mL or greater (66% sensitivity), and 29 with positive scan findings (58% sensitivity). A combination of the 2 methods detected disease in 40 (80%) of 50 patients but failed to show 20% of cases that were identified by sonography and confirmed by fine-needle aspiration. Sonography had sensitivity of 96%. Specificity values for Tg, iodine scanning, and sonography were 80.6%, 90.3%, and 87%, respectively.


CONCLUSIONS
Classic follow-up methods may not detect cervical disease in some patients with differentiated thyroid carcinoma, and sonography is necessary even in patients apparently free of the disease.
Department of Thyroid, Endocrinology and Metabolism Service of Santa Casa de Belo Horizonte, Minas Gerais, Brazil. cepcem.bhz@terra.com.br
Pedro Weslley Souza
PW
do Rosário
Tales Alvarenga
TA
Fagundes
Frederico Fernandes Ribeiro
FF
Maia
Ana Cristina Horta Messias
AC
Franco
Manoela Bertozzi
MB
Figueiredo
Saulo
S
Purisch
D018263:Adenocarcinoma, Follicular / Q000097:blood / Q000000981:diagnostic imaging*; D018249:Adenoma, Oxyphilic / Q000097:blood / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D002291:Carcinoma, Papillary / Q000097:blood / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging*; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood / Q000000981:diagnostic imaging*; D013965:Thyroidectomy; D014463:Ultrasonography
D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes; D013954:Thyroglobulin