Cognitive, but not mood dysfunction develops in multiple sclerosis during 7 years of follow-up.
Long-term development of psychological deficits in disability-free early multiple sclerosis (MS) was evaluated in 27 female patients over a period of 7 years and compared with healthy controls. Physical and cognitive parameters deteriorated significantly but not depression scores. In particular, the self-assessed somatic complaints remained non-similar between patients and controls. This indicates that although depression is clinically relevant and frequent in MS, in contrast to cognition it is not related to physical disease progression.
Haase
C G
CG
Department of Neurology, University Hospital Essen, Essen. scj.haase@t-online.de
Tinnefeld
M
M
Daum
I
I
Ganz
R E
RE
Haupts
M
M
Faustmann
P M
PM
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology*; D003710:Demography; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019964:Mood Disorders / Q000209:etiology*; D009103:Multiple Sclerosis / Q000150:complications*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales