Expression of connexin 26 in the ganglionic eminence of preterm infants after bleedings.
The ganglionic eminence being a prominent part of the telencephalic proliferative zone is the most common site of bleedings in preterm infants. This immunohistochemical study demonstrates that connexin 26 involved in forming intercellular gap junctions is expressed in ganglionic eminence cells up to 500 microm from the bleeding. In controls, no positive cells are present. It is discussed that an increase of gap junctional communication may result in spreading of the primary injury.
Ulfig
Norbert
N
Neuroembryonic Research Laboratory, Department of Anatomy, Faculty of Medicine, University of Rostock, Gertrudenstr. 9, D-18055 Rostock, Germany. norbert.ulfig@med.uni-rostock.de
D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology; D002450:Cell Communication; D002454:Cell Differentiation / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000378:metabolism* / Q000473:pathology; D000072259:Connexin 26; D017630:Connexins / Q000096:biosynthesis*; D005260:Female; D005333:Fetus; D017629:Gap Junctions / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D020547:Lateral Ventricles / Q000196:embryology; D009410:Nerve Degeneration / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D007752:Obstetric Labor, Premature / Q000150:complications*; D011247:Pregnancy; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D013687:Telencephalon / Q000196:embryology* / Q000378:metabolism* / Q000473:pathology
D017630:Connexins; D000072259:Connexin 26