Glycogen autophagy.
Glycogen autophagy, which includes the sequestration and degradation of cell glycogen in the autophagic vacuoles, is a selective process under conditions of demand for the massive hepatic production of glucose, as in the postnatal period. It represents a link between autophagy and glycogen metabolism. The formation of autophagic vacuoles in the hepatocytes of newborn animals is spatially and biochemically related to the degradation of cell glycogen. Many molecular elements and signaling pathways including the cyclic AMP/cyclic AMP-dependent protein kinase and the phosphoinositides/TOR pathways are implicated in the control of this process. These two pathways may converge on the same target to regulate glycogen autophagy.
Department of Anatomy, Histology and Embryology, Medical School, University of Ioannina, Ioannina 451 10, Greece. othonkot@otenet.gr
Othon B
OB
Kotoulas
Stefanos A
SA
Kalamidas
Dimitrios J
DJ
Kondomerkos
D000818:Animals; D000831:Animals, Newborn; D001343:Autophagy; D005260:Female; D022781:Hepatocytes / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051381:Rats; D014617:Vacuoles / Q000502:physiology / Q000648:ultrastructure
D008112:Liver Glycogen