Severe hepatitis C infection in a renal transplant recipient following hepatitis C genotype mismatch transplant.
We report a case of a 32-year-old female with histologically and clinically inactive chronic hepatic C infection, who received a cadaveric renal transplant from a hepatitis C-positive donor with a different genotype. The genotype mismatch (genotype 1 to genotype 2) and change to tacrolimus-based immunosuppression resulted in severe hepatitis C infection characterized by a 10-fold increase in transaminase levels and grade 3 inflammation histologically. Our report highlights the risk of genotype-mismatch transplants in solid organ transplantation.
Section of Hepatology, Ochsner Clinic Foundation, New Orleans, LA, USA.
Thomas
T
Schussler
Catherine
C
Staffeld-Coit
James
J
Eason
Satheesh
S
Nair
D000328:Adult; D001706:Biopsy; D005260:Female; D005838:Genotype; D006084:Graft Rejection; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000209:etiology* / Q000235:genetics* / Q000628:therapy; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016030:Kidney Transplantation / Q000379:methods*; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation / Q000379:methods*; D016133:Polymerase Chain Reaction; D016559:Tacrolimus / Q000494:pharmacology; D013997:Time Factors; D000637:Transaminases / Q000378:metabolism; D014184:Transplantation, Homologous / Q000379:methods; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D000637:Transaminases; D016559:Tacrolimus