Antimicrobial activities of hydrophobic 2-arylbenzofurans and an isoflavone against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus.
Eight 2-arylbenzofurans and an isoflavone isolated from medicinal plants were tested for their antimicrobial activities against vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Among these compounds, six hydrophobic 2-arylbenzofurans (log P = 4.4-8.7) exhibited considerable antibacterial activity against five VRE strains(VanA-, VanB-, and VanC-phenotypes) (MICs = 3.13-6.25 microg/mL). Five compounds also showed antibacterial activity against ten MRSA strains (MIC80 = 3.13 microg/mL).
Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funaba-shi, Chiba 274-8510, Japan. fukai@phar.toho-u.ac.jp
Toshio
T
Fukai
Yukio
Y
Oku
Yoshio
Y
Hano
Sumio
S
Terada
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001572:Benzofurans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016983:Enterococcus / Q000187:drug effects*; D029882:Glycyrrhiza uralensis; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance
D000890:Anti-Infective Agents; D001572:Benzofurans; D007529:Isoflavones; D010936:Plant Extracts; C105430:benzofuran