Nondiabetic ketoacidosis caused by severe hyperthyroidism.
Severe hyperthyroidism is not included in the traditional differential diagnosis of ketoacidosis. However, thyroid hormone has well-documented lipolytic effects on adipocytes and may also promote hepatic beta-oxidation. We present a case in which a woman with severe hyperthyroidism developed otherwise unexplained ketoacidosis during the acute phase of her illness. We propose that thyrotoxicosis was a significant contributor to ketoacidosis in this patient and that severe hyperthyroidism should be added to the differential diagnosis of ketoacidosis.
Department of Medicine, Division of Endocrinology and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, USA.
Emily T
ET
Wood
William B
WB
Kinlaw
D000138:Acidosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D016883:Diabetic Ketoacidosis / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D007659:Ketones / Q000097:blood*; D012720:Severity of Illness Index
D007659:Ketones