Stem cell transplantation for autoimmune disorders. Rheumatoid arthritis.
Haematopoietic stem cell transplantation (HSCT) is now being investigated as a potential therapy for patients with severe refractory rheumatoid arthritis unresponsive to conventional therapies, including tumour necrosis factor-alpha blockade. Pilot studies and an analysis of worldwide cases included in the European Group for Blood and Marrow Transplantation/Autologous Blood and Marrow Transplant Registry registry have enabled the progression of the technique. HSCT is well tolerated in patients with rheumatoid arthritis, and there has been no transplant-related mortality. Although HSCT is not a cure, an improved response to previously ineffective therapies is often seen. Further research is, however, required, and this procedure is still considered appropriate only for those patients for whom there is no reasonable therapeutic alternative. This paper reviews all the previous data relating to HSCT in rheumatoid arthritis, outlines the current stand and discusses future protocol options and research.
Rheumatology Research Unit, Leeds General Infirmary, Old Nurses Home, Great George Street, Leeds LS1 3EX, UK. s.bingham@leeds.ac.uk
S J
SJ
Bingham
J J
JJ
Moore
D001172:Arthritis, Rheumatoid / Q000628:therapy*; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous; D016896:Treatment Outcome