Persistence of a strain of Mycobacterium tuberculosis in a prison system.
METHODS
A prison system with an average year-end census of 9084 inmates.


OBJECTIVE
To determine transmission dynamics of tuberculosis over a long period; to establish whether Mycobacterium tuberculosis strains responsible for disease in a prison system persist; and to determine whether patients in a community whose isolates cluster with those in a prison system are linked.


METHODS
Retrospective epidemiologic analysis was performed on tuberculosis cases reported in a prison system over a 9-year period. In addition, IS6110 RFLP patterns of M. tuberculosis isolates obtained from prisoners were compared with those of other cases from the state at large. The results of the RFLP analysis and the epidemiologic investigation were compared.


RESULTS
Approximately 80% of tuberculosis cases in the prison system were clustered. Over 9 years, a single strain of M. tuberculosis accounted for more than 50% of cases. Patients from the community at large who were infected with the same strain were linked to the prison system.


CONCLUSIONS
In spite of intensive tuberculosis control efforts, a single strain of M. tuberculosis has persisted in the prison system. Its persistence is accounted for by activation of latent infection in patients who, prior to being diagnosed and treated, infected other patients, who then sustained the transmission chain.
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
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Ijaz
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Yang
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Templeton
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Stead
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D000328:Adult; D001131:Arkansas / Q000453:epidemiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D012150:Polymorphism, Restriction Fragment Length; D011329:Prisoners; D012189:Retrospective Studies; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission*