Inherited interstitial lung disease.
This article focuses on recent advances in the identification of genes and genetic polymorphisms that have been implicated in the development of human interstitial lung diseases. It focuses on the inherited mendelian diseases in which pulmonary fibrosis is part of the clinical phenotype and the genetics of familial idiopathic pulmonary fibrosis and other rare inherited interstitial lung diseases. The article also reviews the association studies that have been published to date regarding the genetics of sporadic idiopathic pulmonary fibrosis. The reader is directed to recent reviews on human genetic predisposition of sarcoidosis, environmental-related, drug-related, connective tissue related pulmonary fibrosis, and genetic predisposition of fibrosis in animal models.
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Building NB10.210A, Mail Code 8591, Dallas, TX 75390, USA. Christine.Garcia@UTSouthwestern.edu
Christine Kim
CK
Garcia
Ganesh
G
Raghu
D015897:Comorbidity; D020022:Genetic Predisposition to Disease; D022861:Hermanski-Pudlak Syndrome / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis / Q000235:genetics; D011658:Pulmonary Fibrosis / Q000453:epidemiology / Q000235:genetics