Evaluation of immunological effects of hochu-ekki-to (TJ-41) prophylactic administration in mice.
We evaluated the immunological effects of a Kampo (Chinese) prescription Hochuekki-to (TJ-41) for 32 weeks and 1 week prophylactically in mice, The splenic natural killer cells (NK) of C57BL/6N mice prophylactically treated with TJ-41 for 32 weeks showed little enhanced cytotoxicity against NK-sensitive YAC-1 targets, but mice treated for 1 week showed significantly enhanced cytotoxicity. TJ-41 administration for 32 weeks increased the splenic NK cell population and CD4/CD8 significantly, but TJ-41 for 1 week was not affected. Further, there were no adverse effects of TJ-41 administration for 32 weeks. Whether or not that duration of administration can have the same beneficial effects on humans await further studies.
Department of Bioregulatory Function, Graduate School of Medicine The University of Tokyo, Tokyo 113-8655, Japan. cho-tky@umin.ac.jp
Shigefumi
S
Cho
Tie
T
Hong
Akiyo
A
Kaneko
Gen
G
Yoshino
Noriyuki
N
Sato
Kokichi
K
Kikuchi
Yoshihiro
Y
Aikawa
Fumiko
F
Yasuno
Kazumi
K
Inoue
Jong-Chol
JC
Cyong
D000818:Animals; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D018929:Cell Culture Techniques; D004334:Drug Administration Schedule; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000276:immunology
D015704:CD4 Antigens; D016827:CD8 Antigens; D004365:Drugs, Chinese Herbal; C402943:bu-zhong-yi-qi-tang