Sphingolipid synthesis via olefin cross metathesis: preparation of a differentially protected building block and application to the synthesis of D-erythro-ceramide.
The sphingolipid backbone is readily assembled by E-selective olefin cross metathesis of a suitable building block.
Rai
Anand Narain
AN
Chemistry Department, Brown University Box H, Providence, Rhode Island 02912, USA.
Basu
Amit
A
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D002518:Ceramides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013107:Sphingolipids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000475:Alkenes; D002518:Ceramides; D013107:Sphingolipids