Self-assembly using dynamic combinatorial chemistry.
The principles of an evolution-selection approach to the synthesis of systems capable of molecular recognition are described. Using this dynamic combinatorial self-assembly concept in bulk solution, a variety of successful synthetic receptors have been prepared. The reversible chemistries employed include metalloporphyrin-ligand coordination, hydrazone exchange and disulfide exchange. The prospects for extension of the approach to surfaces are briefly considered.
University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK. jkms@cam.ac.uk
Jeremy K M
JK
Sanders