Effect of hypothalamic electrolytic lesions in White Leghorn and broiler male cockerels.
1. This study compared the effect of bilateral electrolytic lesions of the basomedial hypothalamus (HL) in broiler and White Leghorn (WL) males. 2. Hypothalamic lesions were placed in WL at 10 weeks of age (body weight 1.1 kg) and in broilers, either at 6 weeks (body weight 1.5kg) or at 10 weeks of age (body weight 3.4kg). They were fed ad libitum until autopsy at 16 and 17 weeks of age for broilers and WL, respectively. 3. Hypothalamic lesions caused obesity (high percentage weight of abdominal adipose tissue) in both strains. Obese fowls with unimpaired reproductive systems were classified as OB and those with functional castration as FC (functionally castrated) or FCLC (functionally castrated with large comb). 4. All post-HL syndromes-OB, FC and FCLC-were present in WL, whereas all obese broilers (which are immature at this age) were classified as OB. 5. The percentage weight of abdominal adipose tissue in OB broilers was lower than in OB WL (3% vs 5%, respectively). 6. Daily food intake of OB broilers was higher than control at 12 to 15 weeks of age, regardless of time of placement of HL, whereas daily food intake of OB WL was significantly higher than that of control WL only during the first 2 weeks following HL. 7. Body weight of OB broilers at autopsy was 20% higher than control broilers, whereas body weight of OB WL was not significantly affected. 8. An additional group of broilers was reared to sexual maturity under food restriction until 28 weeks of age. HL were placed at 10 weeks of age (body weight 1.7 kg). Autopsy was performed after a 4-week period of ad libitum feeding. 9. There were OB as well as FC and FCLC among the HL, food-restricted broilers. Percentage weight of testes and spleen were reduced in OB fowls of both strains, but more so in OB WL. 10. Hyperphagia and weight gain were not observed during the ad libitum feeding period of those obese broilers after HL, indicating that hyperphagia and weight gain are secondary to obesity.
Arnon
E
E
Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel.
Snapir
N
N
Robinzon
B
B
Heiblum
R
R
D000005:Abdomen; D000273:Adipose Tissue; D000818:Animals; D001823:Body Composition; D001835:Body Weight; D002645:Chickens; D004435:Eating; D004598:Electrosurgery; D005508:Food Deprivation; D007027:Hypothalamic Diseases / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*; D007033:Hypothalamus, Middle; D008297:Male; D009765:Obesity / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D009919:Orchiectomy / Q000662:veterinary; D009929:Organ Size; D011201:Poultry Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D012098:Reproduction; D013154:Spleen / Q000473:pathology; D013737:Testis / Q000473:pathology