Alcohol, neural stem cells, and adult neurogenesis.
Recent research demonstrates that neural stem cells divide throughout life and give rise to new neurons, a process known as neurogenesis. This article addresses two principal questions concerning alcohol and adult neurogenesis: To what extent are neurogenesis in the adult brain and the risk for alcoholism governed by similar factors? And, to what extent and through what mechanisms do alcohol use and alcoholism affect adult neurogenesis? This article also discusses genetic and environmental influences on risk for alcoholism and on regulation of neurogenesis; the possibility that modulation of neurogenesis contributes to alcoholic pathology; and the evidence that alcohol disrupts neurogenesis in the adult brain, and the neurochemical processes by which this may occur.
Crews
Fulton T
FT
Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, University of North Carolina, Chapel Hill, USA.
Nixon
Kim
K
D000375:Aging / Q000502:physiology*; D000437:Alcoholism / Q000473:pathology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*
D000431:Ethanol