Toll-like receptor pathways in the immune responses to mycobacteria.
The control of Mycobacterium tuberculosis infection depends on recognition of the pathogen and the activation of both the innate and adaptive immune responses. Toll-like receptors (TLR) were shown to play a critical role in the recognition of several pathogens. Mycobacterial antigens recognise distinct TLR resulting in rapid activation of cells of the innate immune system. Recent evidence from in vitro and in vivo investigations, summarised in this review demonstrates TLR-dependent activation of innate immune response, while the induction of adaptive immunity to mycobacteria may be TLR independent.
CNRS, IEM2815, Institut Transgenose, 3B, rue de la Ferollerie, 45071 Orleans, France.
Valerie
V
Quesniaux
Cecile
C
Fremond
Muazzam
M
Jacobs
Shreemanta
S
Parida
Delphine
D
Nicolle
Vladimir
V
Yeremeev
Franck
F
Bihl
Francois
F
Erard
Tania
T
Botha
Michael
M
Drennan
Marie-Noelle
MN
Soler
Marc
M
Le Bert
Bruno
B
Schnyder
Bernhard
B
Ryffel
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology
D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; C050016:lipoarabinomannan