How in vitro techniques have increased our understanding of uveal melanoma cellular biology.
The past decade has seen a rapid increase in powerful in vitro techniques allowing for the specific study of the biologic properties of tumours. In this review we discuss the role of in vitro studies in providing insight into the biologic mechanisms involved in uveal melanoma. We also review the basis of these studies for the development of adjuvant therapies to aid in the treatment of systemic disease in patients with uveal melanoma.
Marshall
Jean-Claude A
JC
Henry C. Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Centre, Montreal, Que.
Caissie
Amanda L
AL
Burnier
Miguel N
MN
D001695:Biology; D017024:Chemotherapy, Adjuvant; D003584:Cytological Techniques; D006801:Humans; D066298:In Vitro Techniques; D008545:Melanoma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D025202:Molecular Diagnostic Techniques; D014407:Tumor Cells, Cultured; D014604:Uveal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy