Sonochemically fabricated microelectrode arrays for biosensors offering widespread applicability: Part I.
A novel and patented procedure is described for the sonochemical fabrication of a new class of microelectrode array based sensor with electrode element populations of up to 2 x 10(5) cm(-2). For some years it has been accepted that microelectrode arrays offer an attractive route for lowering minimum limits of detection and imparting stir (convectional mass transport) independence to sensor responses; despite this no commercial biosensors, to date, have employed microelectrode arrays, largely due to the cost of conventional fabrication routes that have not proved commercially viable for disposable devices. Biosensors formed by our sonochemical approach offer unrivalled sensitivity and impart stir independence to sensor responses. This format lends itself for mass fabrication due to the simplicity and inexpensiveness of the approach; in the first instance impedimetric and amperometric sensors are reported for glucose as model systems. Sensors already developed for ethanol, oxalate and a number of pesticide determinations will be reported in subsequent publications.
Barton
Andrew C
AC
Institute of Bioscience and Technology, Cranfield University at Silsoe, Cranfield Centre for Analytical Science Silsoe, Cranfield, Bedfordshire MK45 4DT, UK.
Collyer
Stuart D
SD
Davis
Frank
F
Gornall
Davinia D
DD
Law
Karen A
KA
Lawrence
Emma C D
EC
Mills
Daniel W
DW
Myler
Suzy
S
Pritchard
Jeanette A
JA
Thompson
Mark
M
Higson
Seamus P J
SP
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004800:Enzymes, Immobilized / Q000032:analysis / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005947:Glucose / Q000032:analysis* / Q000737:chemistry*; D005949:Glucose Oxidase / Q000032:analysis / Q000737:chemistry*; D008420:Manufactured Materials; D008839:Microelectrodes; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013010:Sonication
D020099:Coated Materials, Biocompatible; D004800:Enzymes, Immobilized; D005949:Glucose Oxidase; D005947:Glucose