Chiral benzyl centers through asymmetric catalysis. a three-step synthesis of (R)-(-)-alpha-curcumene via asymmetric hydrovinylation.
[reaction: see text] A three-step, two-pot procedure involving asymmetric hydrovinylation followed by Suzuki-Miyaura reaction represents by far the shortest synthesis of this popular bisabolane. Other applications for the synthesis of similar compounds with chiral benzyl centers can be easily envisioned.
Department of Chemistry, 100 West 18th Avenue, The Ohio State University, Columbus, Ohio 43210, USA.
Aibin
A
Zhang
T V
TV
RajanBabu
D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003474:Curcumin / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis; D007202:Indicators and Reagents; D015394:Molecular Structure; D012717:Sesquiterpenes; D013237:Stereoisomerism
D001555:Benzene Derivatives; D007202:Indicators and Reagents; D012717:Sesquiterpenes; C086829:alpha-curcumene; D003474:Curcumin