Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. A(vy)/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr x VYWffC3Hf/Nctr-A(vy)/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet x genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes.
Kaput
Jim
J
University of California at Davis, Davis, California 95616, USA. jkaput@ucdavis.edu
Klein
Karin G
KG
Reyes
Eric J
EJ
Kibbe
Warren A
WA
Cooney
Craig A
CA
Jovanovic
Borko
B
Visek
Willard J
WJ
Wolff
George L
GL
D000818:Animals; D001947:Breeding; D031204:Caloric Restriction / Q000379:methods*; D002874:Chromosome Mapping / Q000379:methods; D004032:Diet; D002149:Energy Intake / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D005796:Genes / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics; D015430:Weight Gain / Q000235:genetics
D005819:Genetic Markers