Gastric and duodenal mucosal protein fractional synthesis and growth factor expression in patients with H. pylori-associated gastritis before and after eradication of the organism.
Our purpose was to study the effect of Helicobacter pylori (HP) on mucosal protein fractional synthesis (MPFS) and growth factor expression. 14C-leucine incorporation, and TGF-alpha, beta-FGF, and EGF-receptor levels were assessed in gastric and duodenal mucosa in 20 patients with HP-associated gastritis and repeated after treatment of the gastritis, with or without eradication of the organism. At entry, MPFS in the fundus, antrum, and duodenum was 43.1, 38.2, and 28.3%/day, respectively. Following HP eradication, fundal and antral rates fell to 28.1 and 21.4%/day (P < 0.05), whereas the duodenum was unchanged. MPFS in the patient subset not eradicated remained similar to entry values (35.9, 31.6, and 25.4%/day). Expression of TGF-alpha, beta-FGF, and EGF receptors was unchanged. Eradication of HP results in reduction of gastric, but not duodenal, MPFS and has no effect on the growth factors measured. Increased MPFS associated with HP gastritis may relate to the potential for neoplastic transformation.
Winter
Trevor A
TA
Gastrointestinal Clinic, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa. winter@uky.edu
Kidd
Mark
M
Kaye
Philip
P
Marks
I N Solly
IN
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002908:Chronic Disease; D004386:Duodenum / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000188:drug therapy / Q000378:metabolism*; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D007930:Leucine / Q000493:pharmacokinetics; D011849:Radioactive Tracers; D016211:Transforming Growth Factor alpha / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D011849:Radioactive Tracers; D016211:Transforming Growth Factor alpha; D005346:Fibroblast Growth Factors; D066246:ErbB Receptors; D007930:Leucine