Evaluation of immunological effects of hochu-ekki-to (TJ-41) prophylactic administration in mice.
We evaluated the immunological effects of a Kampo (Chinese) prescription Hochuekki-to (TJ-41) for 32 weeks and 1 week prophylactically in mice, The splenic natural killer cells (NK) of C57BL/6N mice prophylactically treated with TJ-41 for 32 weeks showed little enhanced cytotoxicity against NK-sensitive YAC-1 targets, but mice treated for 1 week showed significantly enhanced cytotoxicity. TJ-41 administration for 32 weeks increased the splenic NK cell population and CD4/CD8 significantly, but TJ-41 for 1 week was not affected. Further, there were no adverse effects of TJ-41 administration for 32 weeks. Whether or not that duration of administration can have the same beneficial effects on humans await further studies.
Cho
Shigefumi
S
Department of Bioregulatory Function, Graduate School of Medicine The University of Tokyo, Tokyo 113-8655, Japan. cho-tky@umin.ac.jp
Hong
Tie
T
Kaneko
Akiyo
A
Yoshino
Gen
G
Sato
Noriyuki
N
Kikuchi
Kokichi
K
Aikawa
Yoshihiro
Y
Yasuno
Fumiko
F
Inoue
Kazumi
K
Cyong
Jong-Chol
JC
D000818:Animals; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D018929:Cell Culture Techniques; D004334:Drug Administration Schedule; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000276:immunology
D015704:CD4 Antigens; D016827:CD8 Antigens; D004365:Drugs, Chinese Herbal; C402943:bu-zhong-yi-qi-tang