Simulating genetic networks made easy: network construction with simple building blocks.
We present SIM-plex, a genetic network simulator with a very intuitive interface in which a user can easily specify interactions as simple 'if-then' statements. The simulator is based on the mathematical model of Piecewise Linear Differential Equations (PLDEs). With PLDEs, genetic interactions are approximated as acting in a switch-like manner.


BACKGROUND
The Java program, examples and a tutorial are available at http://www.psb.ugent.be/cbd/


BACKGROUND
{stcru,makui}@psb.ugent.be
Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University Technologiepark 927, B-9052, Gent, Belgium.
Steven
S
Vercruysse
Martin
M
Kuiper
D000465:Algorithms; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D020407:Internet; D008957:Models, Genetic; D011381:Programming Languages; D015398:Signal Transduction / Q000502:physiology*; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*; D014584:User-Computer Interface
D014157:Transcription Factors