Motor execution and imagination networks in post-stroke dystonia.
Reorganization of motor execution and imagination networks was studied in six patients with unilateral dystonia secondary to a subcortical stroke and compared with seven control subjects using fMRI. Patients performed imagined and real auditory-cued hand movements. Movements of the dystonic hand resulted in overactivity in bilateral motor, premotor, and prefrontal cortex, insula, precuneus, and cerebellum, in parietal areas and the striatum contralateral to the lesion. Movements of the unaffected hand resulted in overactivity in bilateral preSMA, prefrontal, and parietal areas, insula and cerebellum, the ipsilateral premotor cortex and the contralateral striatum to the lesion. Mental representation of movements with each hand resulted in overactivity in bilateral parietal, premotor and prefrontal areas. These results suggest that execution and mental representation of movement are altered in these patients.
Lehéricy
Stéphane
S
Service Hospitalier Frédéric Joliot, CEA, Orsay, France. stephane.lehericy@psl.ap-hop-paris.fr
Gerardin
Emmanuel
E
Poline
Jean-Baptiste
JB
Meunier
Sabine
S
Van de Moortele
Pierre-Francois
PF
Le Bihan
Denis
D
Vidailhet
Marie
M
D000328:Adult; D000368:Aged; D001931:Brain Mapping; D016022:Case-Control Studies; D004421:Dystonia / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006225:Hand / Q000503:physiopathology; D006801:Humans; D007092:Imagination / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011340:Problem Solving / Q000502:physiology*; D020521:Stroke / Q000150:complications
D010100:Oxygen