Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia.
Schizophrenia is characterized by thought disorders, hallucinations and delusions. Genetic studies have shown a high linkage at chromosome 6q16-21. Among the genes located in this region is the glutamate receptor ionotropic kainate 2 gene (GRIK2 or GLUR6), a functional candidate for susceptibility to schizophrenia. In this study, transmission of GRIK2 was evaluated in 356 schizophrenic patients from three different clinical centers. Whereas paternal transmission shows equilibrium, we observed maternal transmission disequilibrium of GRIK2 in the largest population (p=0.03), which was still significant when all populations were added (p=0.05). These results are similar to the maternal GRIK2 transmission disequilibrium previously reported for autism, and support the presence of a susceptibility gene for schizophrenia at 6q16.
Human Genetics and Cognitive Functions, Universite Paris 7, Institut Pasteur, 25, rue du docteur Roux, 75724 Paris Cedex 15, France.
J
J
Bah
H
H
Quach
R P
RP
Ebstein
R H
RH
Segman
J
J
Melke
S
S
Jamain
M
M
Rietschel
I
I
Modai
K
K
Kanas
O
O
Karni
B
B
Lerer
D
D
Gourion
M O
MO
Krebs
B
B
Etain
F
F
Schürhoff
A
A
Szöke
M
M
Leboyer
T
T
Bourgeron
D000483:Alleles; D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D004198:Disease Susceptibility; D005260:Female; D023281:Genomics; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009035:Mothers; D020641:Polymorphism, Single Nucleotide; D018092:Kainic Acid Receptors / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D000097806:GluK2 Kainate Receptor
D018092:Kainic Acid Receptors; D000097806:GluK2 Kainate Receptor