Nipple core biopsy for the deformed or scaling nipple.
The key to diagnosis for deformed or scaling nipple is cytology or histology. While scrape cytology and punch biopsy do not provide underlying breast tissue for histology wedge excision requires more time and resource. We present the technique of nipple core biopsy (NCB) in 40 patients with deformed or scaling nipple done as a part of triple assessment yielding both skin and breast tissue for histological examination. Histological diagnosis confirmed eczema in 24, Paget's disease of nipple in 9 and chronic inflammation in 2. Among 5 remaining patients with normal skin histology, underlying breast invasive ductal carcinoma was seen in 3, ductal carcinoma in situ (DCIS) in 1 and adenoma in 1. NCB identified 5(55%) significant breast pathologies in Paget's disease and detected a further 2 invasive cancers in the absence of a palpable mass. The technique also provides additional information in the form of oestrogen receptor, which can have direct impact on patient management.
Department of Surgery, New Cross Hospital, Royal Woverhampton NHS Trust, Woverhampton WV 10 0QP, UK.
K R
KR
Aryal
A J
AJ
Lengyel
N
N
Purser
N
N
Harrison
N
N
Aluwihare
B
B
Isgar
D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D001943:Breast Neoplasms / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis*; D004485:Eczema / Q000175:diagnosis*; D005260:Female; D006801:Humans; D009558:Nipples / Q000473:pathology*; D010144:Paget's Disease, Mammary / Q000175:diagnosis*; D011960:Receptors, Estrogen / Q000032:analysis
D011960:Receptors, Estrogen