[Expression of factors inducing apoptosis of peripheral blood lymphocytes in oral cavity cancers].
One of possible immunosuppression mechanisms during cancer disease is apoptotic death of immunology system cells. Factor FAS and xi chain of TCR-CD3 complex take part in induction of apoptosis of lymphocyte which infiltrate neoplasm as well as lymphocytes of peripheral blood (PBL). Expression of the two factors was estimated in PBL of patients with cancer of bottom of oral cavity and granuloma fissuratum (control group). During cancer disease higher level of FAS factor in PBL was observed in comparison to control group. Lymphocytes of peripheral blood in cases of cancer disease shown lower expression of TCR-xi.
Nowaczyk
Marian T
MT
Klinika Chirurgii Szczekowo-Twarzowej AM w Poznaniu.
Sikora
Jan
J
D000328:Adult; D017209:Apoptosis / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood; D053222:Fas Ligand Protein; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006099:Granuloma / Q000276:immunology; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D009059:Mouth Diseases / Q000276:immunology; D009062:Mouth Neoplasms / Q000276:immunology*; D011044:Poland; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000097:blood*; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology*
D014408:Biomarkers, Tumor; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D017260:Receptor-CD3 Complex, Antigen, T-Cell