Arginine methylation regulates the cytokine response.
The recent identification of the NFAT-interacting protein NIP45 as a methylated protein by marks a new role for protein arginine methylation in lymphocyte signaling and cytokine gene activation.
Boisvert
François-Michel
FM
Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Departments of Oncology and Medicine, McGill University, Montréal, Québec, Canada H3T 1E2.
Richard
Stéphane
S
D001120:Arginine / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D047908:Intracellular Signaling Peptides and Proteins; D008745:Methylation; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins / Q000378:metabolism; D011484:Protein-Arginine N-Methyltransferases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation
D002352:Carrier Proteins; D016207:Cytokines; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D050778:NFATC Transcription Factors; C102566:Nfatc2ip protein, mouse; D009687:Nuclear Proteins; D014157:Transcription Factors; D001120:Arginine; D011484:Protein-Arginine N-Methyltransferases