Matrix metalloproteinase genes in Xenopus development.
Matrix metalloproteinases (MMPs) are a large family of proteins in vertebrates, consisting of over 24 genes in humans, only a few of which have been identified in Xenopus. Three genes coding for MMPs in Xenopus have been identified and their expression studied during development. The membrane-bound XMMP-14 and -15 (XMT1-MMP and XMT2-MMP) both showed restricted expression patterns, the former principally localising to cranial neural crest tissues and the latter to the epidermis of the embryo. XMMP-7 codes for an MMP that lacks the hemopexin-like domain. It is expressed exclusively in macrophages or other myeloid cell types from early in development.
School of Biological Sciences, University of East Anglia, Norwich, United Kingsom.
Michael
M
Harrison
Muhammad
M
Abu-Elmagd
Timothy
T
Grocott
Clara
C
Yates
Jelena
J
Gavrilovic
Grant N
GN
Wheeler
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular / Q000379:methods; D019295:Computational Biology; D004625:Embryo, Nonmammalian / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D014981:Xenopus / Q000196:embryology* / Q000235:genetics
D020782:Matrix Metalloproteinases