Spatial patterns of gene expression in the olfactory bulb.
How olfactory sensory neurons converge on spatially invariant glomeruli in the olfactory bulb is largely unknown. In one model, olfactory sensory neurons interact with spatially restricted guidance cues in the bulb that orient and guide them to their target. Identifying differentially expressed molecules in the olfactory bulb has been extremely difficult, however, hindering a molecular analysis of convergence. Here, we describe several such genes that have been identified in a screen that compiled microarray data to create a three-dimensional model of gene expression within the mouse olfactory bulb. The expression patterns of these identified genes form the basis of a nascent spatial map of differential gene expression in the bulb.
Lin
David M
DM
Department of Molecular and Cell Biology, Functional Genomics Laboratory, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
Yang
Yee Hwa
YH
Scolnick
Jonathan A
JA
Brunet
Lisa J
LJ
Marsh
Heather
H
Peng
Vivian
V
Okazaki
Yasushi
Y
Hayashizaki
Yoshihide
Y
Speed
Terence P
TP
Ngai
John
J
D000818:Animals; D001931:Brain Mapping; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D017403:In Situ Hybridization; D051379:Mice; D009475:Neurons, Afferent / Q000166:cytology / Q000378:metabolism; D009830:Olfactory Bulb / Q000033:anatomy & histology / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D015203:Reproducibility of Results; D012903:Smell / Q000502:physiology*