Description of a new HLA-DRB1 allele, DRB1*1150.
We report the identification of a novel HLA-DRB1*11 using sequence-based typing. This new allele, officially named DRB1*1150, was detected while performing HLA-DRB1 high-resolution typing of a candidate for bone marrow transplantation. DRB1*1150 is identical to DRB1*1143 except at nucleotides 200 and 227, where a T is substituted by a C and a T by an A, respectively. These differences give rise to two amino acid substitutions at codons 38 (Val-->Ala) and 47 (Phe-->Tyr).
Dipartimento di Medicina Trasfusionale e di Riferimento per i Trapianti di Organi e Tessuti -- Unità Operativa per il Prelievo e la Conservazione di Organi e Tessuti, Ospedale Maggiore Policlinico IRCCS, Milan, Italy.
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Crespiatico
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Frison
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Andreini
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Ferrioli
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Rossi
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Poli
D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D016026:Bone Marrow Transplantation; D005091:Exons; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C497140:HLA-DRB1*11:50 antigen