Antibiotic susceptibility patterns among respiratory isolates of Gram-negative bacilli in a Turkish university hospital.
BACKGROUND
Gram-negative bacteria cause most nosocomial respiratory infections. At the University of Cumhuriyet, we examined 328 respiratory isolates of Enterobacteriaceae and Acinetobacter baumanii organisms in Sivas, Turkey over 3 years. We used disk diffusion or standardized microdilution to test the isolates against 18 antibiotics.


RESULTS
We cultured organisms from sputum (54%), tracheal aspirate (25%), and bronchial lavage fluid (21%). The most common organisms were Klebsiella spp (35%), A. baumanii (27%), and Escherichia coli (15%). Imipenem was the most active agent, inhibiting 90% of Enterobacteriaceae and A. baumanii organisms. We considered approximately 12% of Klebsiella pneumoniae and 21% of E. coli isolates to be possible producers of extended-spectrum beta-lactamase. K. pneumoniae isolates of the extended-spectrum beta-lactamase phenotype were more resistant to imipenem, ciprofloxacin, and tetracycline in our study than they are in other regions of the world.


CONCLUSIONS
Our results suggest that imipenem resistance in our region is growing.
Gonlugur
Ugur
U
Department of Chest Diseases, Cumhuriyet University Medical School, 58140, Sivas, Turkey. gonlugur@e-kolay.net
Bakici
Mustafa Zahir
MZ
Akkurt
Ibrahim
I
Efeoglu
Tanseli
T
D000150:Acinetobacter / Q000187:drug effects / Q000302:isolation & purification; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000453:epidemiology; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000453:epidemiology; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000453:epidemiology; D006785:Hospitals, University / Q000639:trends*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D014421:Turkey / Q000453:epidemiology
D000900:Anti-Bacterial Agents