Increased cystatin C concentration in urine of nephrotic children.
The aim of this study was to evaluate changes in urine and plasma concentrations of cystatin C in children with a relapse of the idiopathic nephrotic syndrome(INS). The study group comprised 12 children with INS with proteinuria and 12 children in an 8-week remission,both treated with steroids. Twelve healthy children served as controls. Cystatin C was detectable in the urine of children with proteinuria. The study suggests that massive proteinuria may influence renal cystatin C handling.
Department of Nephrology and Dialysis, Polish Mother's Memorial Hospital Research Institute, Łódź, Poland. mtkaczyk@uni.lodz.pl
Marcin
M
Tkaczyk
Michał
M
Nowicki
Jolanta
J
Lukamowicz
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D055316:Cystatin C; D015891:Cystatins / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood* / Q000150:complications / Q000652:urine*; D011507:Proteinuria / Q000097:blood / Q000209:etiology / Q000652:urine; D012008:Recurrence
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins