Stereoselective synthesis of (+)-boronolide and its 8-epimer.
Starting from readily available carbohydrates the synthesis of 8-epi-(+)-boronolide 19 and (+)-boronolide was achieved with diastereoselective propargylation of alpha-oxygenated aldehyde as a key step.
Hu
Shou-Gang
SG
State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, 200032, China.
Hu
Tai-Shan
TS
Wu
Yu-Lin
YL
D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D019686:Lamiaceae / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D007783:Lactones; C469612:boronolide