Improving catalyst scope: use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization.
[reaction: see text] Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization-trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.
Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA. jtakacs1@unl.edu
James M
JM
Takacs
Jianxin
J
Han
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000475:Alkenes; D000814:Aniline Compounds; D010165:Palladium