Mitochondrial redox control of matrix metalloproteinases.
Reactive oxygen species (ROS) are constantly generated in aerobic organisms during normal metabolism and in response to both internal and external stimuli. Imbalances in the production and removal of ROS have been hypothesized to play a causative role in numerous disease pathologies such as cancer, ischemia/reperfusion injury, and degenerative diseases such as photoaging, atherosclerosis, arthritis, and neurodegeneration. A feature often associated with these diseases is a malfunctioning of the connective tissue remodeling process due to increased activity of extracellular matrix-degrading metalloproteinases (MMPs). This review summarizes the evidence that implicates ROS as key regulators of MMP production and the importance of these interactions in disease pathologies.
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Kristin K
KK
Nelson
J Andres
JA
Melendez
D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003238:Connective Tissue / Q000473:pathology; D004789:Enzyme Activation; D005109:Extracellular Matrix / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008027:Light; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000473:pathology; D010084:Oxidation-Reduction; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D015427:Reperfusion Injury; D015398:Signal Transduction; D012867:Skin / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D000099156:Superoxide Dismutase 2
D000975:Antioxidants; D020781:Matrix Metalloproteinase 1; D020782:Matrix Metalloproteinases; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2