Chron's disease, rare association with selective IgA immunodeficiency, and development of life-threatening bacterial infections.
Life-threatening necrotizing fasciitis and relapsing Lemierre syndrome associated with Fusobacterium necrophorum septicaemia occurred in young adults with a moderate Chron's disease and a missed profound IgA deficiency. This unexpected association of a chronic bowel inflammatory syndrome with prominent IgA abnormalities and severe bacterial infection deserves careful attention by physicians faced with young patients with Chron's disease.
Manfredi
Roberto
R
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna 'Alma Mater Studiorum', S. Orsola Hospital, Bologna, Italy. manfredi@med.unibo.it
Coronado
Olga V
OV
Marinacci
Ginevra
G
Righi
Mauro
M
Calza
Leonardo
L
D000328:Adult; D003424:Crohn Disease / Q000150:complications*; D019115:Fasciitis, Necrotizing / Q000382:microbiology*; D005674:Fusobacterium Infections / Q000382:microbiology*; D005675:Fusobacterium necrophorum / Q000472:pathogenicity; D006801:Humans; D017098:IgA Deficiency / Q000150:complications*; D008297:Male; D000039:Peritonsillar Abscess / Q000382:microbiology; D018805:Sepsis / Q000382:microbiology*; D013577:Syndrome; D020246:Venous Thrombosis / Q000382:microbiology