Extensive proteinuria in rats after single dose of adriamycin--etiology.
The purpose of the present studies was to find the cause of proteinuria, which is displayed in rats after one dose of adriamycin. The results show electrostatic (decreased amount of negative charges in glomerulus) and morphological damage of kidney filtration barriers, which causes increased permeability of basal membranes for proteins. An important part in etiology seems to played by free radicals, which arise in the process of adriamycin transformation.
Department and Institute of Histology and Embryology with the Laboratory for Experimental Cytology, Medical University of Lublin.
Agnieszka
A
Pedrycz
Krystyna
K
Czerny
Marcin
M
Wieczorski
Joanna
J
Sekita-Krzak
Beata
B
Cichacz
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology* / Q000648:ultrastructure; D011507:Proteinuria / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin