Dizocilpine blocks the effects of delta sleep-inducing peptide-induced suppression of c-fos gene expression in the paraventricular nucleus of the hypothalamus in rats.
The characteristics of the actions of the non-competitive blocker of NMDA receptors dizocilpine on the expression of the early c-fos gene in the paraventricular nuclei of the hypothalamus were studied in rats with different predicted susceptibilities to emotional stress in conditions of treatment with delta sleep-inducing peptide. The results showed that prior treatment with dizocilpine blocked reductions in c-fos expression induced by delta sleep peptide.
P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, 11/4 Mokhovaya Street, 103009 Moscow, Russia.
P E
PE
Umryukhin
K V
KV
Anokhin
K S
KS
Raevskii
D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology / Q000502:physiology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism
D016760:Proto-Oncogene Proteins c-fos; D016194:Receptors, N-Methyl-D-Aspartate; D003701:Delta Sleep-Inducing Peptide; D016291:Dizocilpine Maleate