Variability of thyroid blood flow Doppler parameters in healthy women.
The purpose of this study was to estimate variability of flow Doppler parameters in the superior thyroid artery (STHA) during the menstrual cycle in young women and to explore the influence of endogenous 17-b-estradiol (E2) and progesterone (PRG) on the velocity waveform. The plasma concentration of these hormones was correlated with flow velocities, pulsatility index (PUI), resistance index (RI) and acceleration index (accI) and time (accT), which were measured with color-coded duplex sonography 8 times during the cycle in 14 healthy women (age range: 23 to 25 years). Coefficient of variation (CV), interclass correlation (ICC), repeatability (repC) and pooled Pearson correlation (r) coefficients were used to estimate the variability of the parameters. The highest variability was found for accI and accT: CV = 48% and 31%; ICC = 0.51 and 0.45; repC = 2.8 and 95; r = 0.37 and 0.4, respectively. The CV for flow velocities varied from 25% to 26%, ICC from 0.53 to 0.56, repC from 8 to 17 and r has a value of 0.46. The respective values for RI and PUI were: 11%, 18%; 0.48, 0.55; 0.15, 0.48; and 0.46, 0.48. The diastolic blood pressure decreased significantly by 7 mmHg (p < 0.01) in the luteal phase, whereas other physiological variables were stable during the cycle. Although the fluctuations of the flow parameters during the cycle were not statistically significant, a weak linear correlation between flow velocities and concentration of E2 was found; for mean velocity r = 0.16, p < 0.05. Impedance indices showed an increasing trend in the luteal phase, along with increase of the pulse pressure index (PPI). The results showed that variability of the flow parameters in the STHA is substantial and that higher flow velocities are associated with increase of plasma concentration of 17-b-estradiol during the menstrual cycle in young women.
Department of Radiology, Bialystok University School of Medicine, Bialystok, Poland. Jaroslaw.krejza@uphs.upenn.edu
Jaroslaw
J
Krejza
Agnieszka
A
Nowacka
Agnieszka
A
Szylak
Michel
M
Bilello
Lina Y
LY
Melhem
D000328:Adult; D000704:Analysis of Variance; D001158:Arteries; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood / Q000502:physiology*; D011374:Progesterone / Q000097:blood; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D013599:Systole; D013961:Thyroid Gland / Q000098:blood supply / Q000000981:diagnostic imaging*; D018616:Ultrasonography, Doppler, Duplex; D014655:Vascular Resistance
D004967:Estrogens; D011374:Progesterone