Prenatal and postnatal steroid therapy and child neurodevelopment.
In recent years, scientific evidence has accumulated on the potential neuro-toxic effects of perinatal steroid therapy on the incompletely developed brain; therefore, much effort has been directed toward finding the optimal regimen that may reduce lung disease without incurring significant brain injury in fetuses and preterm infants. Current recommendations of the NIH endorse a single course of prenatal steroids in cases of imminent preterm delivery. Postnatal steroid therapy should be limited, according to the American Association of Pediatrics Guide-lines, to selected clinical cases after the first week of life. These cautions aim to decrease possible harmful effects that could affect short- and long-term neuro-developmental outcome in this high-risk population.
Friedman
Smadar
S
Department of Neonatology, Kaplan Medical Center, PO Box 1, Rehovot 76100, Israel. smadar_e@clalit.org.il
Shinwell
Eric S
ES
D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000517:prevention & control*; D009422:Nervous System Diseases / Q000139:chemically induced*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D012307:Risk Factors
D000305:Adrenal Cortex Hormones