[Morphofunctional characteristics of secretion-producing structures of the gastric and duodenal mucosa in liquidators of aftermaths of the Chernobyl accident with peptic ulcer of the duodenum].
With the aid of the comparative structural analysis of 145 biopsy specimens of the gastric and duodenal mucosa obtained from two groups of patients with peptic ulcer of the duodenum (liquidators of effects of the Chernobyl power plant accident and those subjects comprizing the control group), particular morphological features were revealed in the liquidators. These included the following: significant decline in parameters for parietal cells (mostly nuclei), striking alterable changes in their cytoplasma; transformation of the process of glycosylation of glycoproteins in the course of mucus production with disturbances of formation, excertion of the secretion and cytoprotective properties of the mucus; increase in the proliferative activity of the epithelium with insufficiency of cytodifferentiation and functional inadequacy.
Dehtiar'ova
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Kozlova
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D001706:Biopsy; D004381:Duodenal Ulcer / Q000473:pathology*; D004386:Duodenum / Q000648:ultrastructure*; D005753:Gastric Mucosa / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000648:ultrastructure; D009784:Occupational Diseases / Q000473:pathology*; D018788:Radioactive Hazard Release; D014455:Ukraine