Simulating complex intracellular processes using object-oriented computational modelling.
The aim of this paper is to give an overview of computer modelling and simulation in cellular biology, in particular as applied to complex biochemical processes within the cell. This is illustrated by the use of the techniques of object-oriented modelling, where the computer is used to construct abstractions of objects in the domain being modelled, and these objects then interact within the computer to simulate the system and allow emergent properties to be observed. The paper also discusses the role of computer simulation in understanding complexity in biological systems, and the kinds of information which can be obtained about biology via simulation.
Johnson
Colin G
CG
Computing Laboratory, University of Kent, Canterbury, CT2 7NF, UK. c.g.johnson@kent.ac.uk
Goldman
Jacki P
JP
Gullick
William J
WJ
D000818:Animals; D002468:Cell Physiological Phenomena; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D042541:Intracellular Space / Q000502:physiology; D008660:Metabolism / Q000502:physiology*; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism; D011381:Programming Languages; D015398:Signal Transduction / Q000502:physiology*
D009097:Multienzyme Complexes