[Xenon - noble gas with organprotective properties].
Besides it's anaesthetic properties, xenon may induce biological effects that may protect various organs from ischaemia-reperfusion injury. Xenon is an antagonist of the NMDA-receptor and reduces the neuronal injury mediated via these receptors. In contrast to other NMDA-receptor antagonists, xenon has no neurotoxic side effects. Xenon also protects the heart in ischaemia-reperfusion situations. Xenon reduces the post-ischaemic reperfusion injury and offers cardioprotection by inducing pharmacological preconditioning. These organ protective properties of xenon might be useful in special clinical situations.
Klinik für Anästhesiologie, Universitätsklinikum Düsseldorf. preckel@med.uni-duesseldorf.de
B
B
Preckel
N
N
Weber
W
W
Schlack
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D018696:Neuroprotective Agents; D020011:Protective Agents; D014978:Xenon / Q000494:pharmacology*
D018685:Anesthetics, Inhalation; D018696:Neuroprotective Agents; D020011:Protective Agents; D014978:Xenon