[Immunopathogenesis of diabetes mellitus I].
The pathogenesis of diabetes mellitus I is multifactorial. Both genetic predisposition and environmental factors are involved in the deregulation of immune system with subsequent breakage of self-tolerance. Autoantibodies against numerous autoantigens are raised during this long-term process but the principal pathogenic mechanism is cytotoxic killing of beta cells of pancreas mediated predominantly by T cells. There could be the chance to interrupt this pathogenetic process by manipulation with immune system to achieve induction of tolerance. Such clinical trials are now under progress.
Ustav klinické imunologie a alergologie Lékarské fakulty UK a FN, Hradec Králové.
J
J
Krejsek
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J
Novosad
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O
Kopecký
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D020022:Genetic Predisposition to Disease; D006801:Humans