Epstein-Barr virus-infected malignant T/NK-cell lymphoma in a patient with hypersensitivity to mosquito bites.
We report an autopsy case of Epstein-Barr virus (EBV)-infected malignant lymphoma in a young male who had hypersensitivity to mosquito bites. The autopsy revealed multiple confluent lymphoma lesions in the lungs, and on the right leg irregular-shaped skin ulcers were seen. The left pleural effusion also contained a large number of lymphoma cells. The lymphoma cells were determined as T/NK-cell type cells by immunohistochemistry. EBV DNA was detected most intensively in the lungs and EBV-encoded small RNAs-positive lymphoma cells were also observed in the lungs at a high frequency. EBV latent membrane protein-1 expression and a high Ki-67 labeling indices were noted in the lymphoma cells of the lung lesions. These findings indicate that the development of the malignant lymphoma was associated with the proliferation of EBV-infected lymphoma cells, and the cells that infiltrated the whole the body, especially the lungs, caused the patient's death.
Kase
Satoru
S
Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Yonago, Japan.
Adachi
Hironobu
H
Osaki
Mitsuhiko
M
Murakami
Masanao
M
Sairenji
Takeshi
T
Hashimoto
Kiyoshi
K
Teramoto
Hidemi
H
Yamamoto
Shisei
S
Makino
Haruhiko
H
Shimizu
Eiji
E
Watanabe
Tessin
T
Ohsawa
Tokuya
T
Hagari
Yoshitaka
Y
Mihara
Motoyuki
M
Ito
Hisao
H
D000293:Adolescent; D000818:Animals; D009033:Culicidae / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000473:pathology; D004854:Herpesvirus 4, Human; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007299:Insect Bites and Stings / Q000276:immunology*; D007694:Killer Cells, Natural; D008168:Lung / Q000473:pathology / Q000821:virology; D016399:Lymphoma, T-Cell / Q000821:virology*; D008297:Male; D016133:Polymerase Chain Reaction; D012867:Skin / Q000276:immunology / Q000473:pathology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000473:pathology
D004279:DNA, Viral