Cystic kidney diseases: all roads lead to the cilium.
Cystic kidney disorders are one of the leading causes of end-stage renal disease. Numerous experimental animal models have been used to understand the disease pathogenesis. Recent advancements in this field have provided a surprising finding: that many of the proteins associated with cystic kidney disease localize to a nearly forgotten organelle, the primary cilium.
Zhang
Qihong
Q
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Taulman
Patrick D
PD
Yoder
Bradley K
BK
D000818:Animals; D002923:Cilia / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007684:Kidney Tubules / Q000473:pathology* / Q000648:ultrastructure; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics / Q000473:pathology*