Red cell glucose-6-phosphate dehydrogenase phenotypes in Iraq.
We attempted to characterize biochemically glucose-6-phosphate dehydrogenase (G6PD) variants in Iraqi individuals. Thus 758 healthy Iraqi males aged 18-60 years were randomly selected and 46 (6.1%) were G6PD deficient. Although the predominant non-deficient G6PD phenotype was G6PD B (92.6%), G6PD A+ was found in polymorphic frequency (1.3%). In the deficient group, 31 cases were fully characterized, including 17 cases with features consistent with G6PD Mediterranean variant, while 12 had other biochemical features and were labelled as non-Mediterranean variant. The remaining two deficient cases were characterized as G6PD A- variant. The presence of a significant number of non-Mediterranean variant was unexpected and may be related to the more heterogeneous background of the Iraqi people.
Hilmi
F A
FA
Department of Pathology, College of Medicine, University of Baghdad, Baghdad, Iraq.
Al-Allawi
N A
NA
Rassam
M
M
Al-Shamma
G
G
Al-Hashimi
A
A
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004588:Electrophoresis, Cellulose Acetate; D004912:Erythrocytes / Q000201:enzymology; D005236:Favism / Q000453:epidemiology / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics*; D018740:Genetic Heterogeneity; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics*; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D007493:Iraq / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D014504:Urban Health / Q000706:statistics & numerical data
D005954:Glucosephosphate Dehydrogenase; C482910:glucose-6-phosphate dehydrogenase A-