Usefulness of magnifying endoscopic evaluation of the terminal ileum for a patient with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
The gastrointestinal tract is one of the common targets of acute graft-versus-host disease (GVHD), but accurate diagnosis is difficult because of the nonspecific nature of complicated diseases and the lack of diagnostic findings by conventional endoscopy. Recently, a magnifying endoscope has been developed and used for examining microstructures of the mucosa. Herein, we report the first use of a magnifying endoscope for a patient with gastrointestinal (GI) GVHD. Magnified endoscopic findings of atrophic and coalescent villi of the terminal ileum reflect histological findings of GVHD. Magnifying endoscopy of the terminal ileum may be useful for early detection and follow-up of GI GVHD.
Onozawa
Masahiro
M
Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan. masahiro.onozawa@nifty.ne.jp
Yonezumi
Masakatsu
M
Kawarazaki
Mitsuru
M
Izumiyama
Koh
K
Chiba
Kouji
K
Kondo
Takeshi
T
Ota
Shuichi
S
Kobayashi
Sumiko
S
Kato
Mototsugu
M
Hashino
Satoshi
S
Tanaka
Junji
J
Imamura
Masahiro
M
Asaka
Masahiro
M
D000293:Adolescent; D016145:Endoscopy, Digestive System / Q000379:methods*; D006086:Graft vs Host Disease / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007077:Ileal Diseases / Q000473:pathology; D007082:Ileum / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D014184:Transplantation, Homologous