Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy.
This study assessed the impact of coronary vascular adaptive remodeling and coronary vascular reactivity on myocardial ischemia in patients with hypertension and left ventricular hypertrophy. Myocardial ischemia is associated with impaired endothelium-independent vasodilation of resistance coronary arteries and increased minimal coronary resistance. These changes may occur in association with lumen reduction caused by attenuated adaptive remodeling in response to plaque accumulation.
Kataoka
Tetsuro
T
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Hamasaki
Shuichi
S
Ishida
Sanemasa
S
Saihara
Keishi
K
Okui
Hideki
H
Fukudome
Tsuyoshi
T
Shinsato
Takurou
T
Mizoguchi
Etsuko
E
Ninomiya
Yuichi
Y
Otsuji
Yutaka
Y
Minagoe
Shinichi
S
Tei
Chuwa
C
D000109:Acetylcholine; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D002306:Cardiac Volume / Q000502:physiology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D015902:Gamma Cameras; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*; D005996:Nitroglycerin; D010208:Papaverine; D013223:Statistics as Topic; D013794:Thallium Radioisotopes; D018084:Ultrasonography, Interventional; D014655:Vascular Resistance / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology; D014665:Vasodilator Agents; D020257:Ventricular Remodeling / Q000502:physiology*
D013794:Thallium Radioisotopes; D014665:Vasodilator Agents; D010208:Papaverine; D005996:Nitroglycerin; D000109:Acetylcholine