Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex.
The effect of Gly-Pro-Glu (GPE) on the somatostatinergic system of the temporal cortex in amyloid beta-peptide (Abeta) treated rats was investigated. Intracerebroventricular Abeta25-35 administration for 14 days (300 pmol/day) to ovariectomized rats produced a marked reduction in somatostatin (SRIF) content, SRIF receptor density and reduced the inhibitory effect of SRIF on adenylyl cyclase activity. I.p. injection of three doses (300 microg) of GPE on days 0, 6 and 12 resulted in a partial recovery of the parameters affected by Abeta25-35 administration. These results indicate that GPE may have an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult.
Department of Endocrinology and Research Laboratory Hospital Infantil Universitario Niño Jesús, Universidad Autónoma, E-28009 Madrid, Spain.
David
D
Aguado-Llera
Mercedes
M
Martín-Martínez
María Teresa
MT
García-López
Eduardo
E
Arilla-Ferreiro
Vicente
V
Barrios
D000262:Adenylyl Cyclases / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001665:Binding Sites; D015153:Blotting, Western / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010052:Ovariectomy / Q000379:methods; D010446:Peptide Fragments / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D017481:Receptors, Somatostatin / Q000378:metabolism; D013004:Somatostatin / Q000172:deficiency / Q000187:drug effects*; D013702:Temporal Lobe / Q000187:drug effects* / Q000378:metabolism*; D013997:Time Factors
D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D009842:Oligopeptides; D010446:Peptide Fragments; D017481:Receptors, Somatostatin; D013004:Somatostatin; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D000262:Adenylyl Cyclases; C062053:glycyl-prolyl-glutamic acid