Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging.
Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.
Nagae-Poetscher
Lidia M
LM
Kennedy Krieger Institute, Baltimore, Maryland, USA.
McMahon
Michael
M
Braverman
Nancy
N
Lawrie
William T
WT
Fatemi
Ali
A
Degaonkar
Mahaveer
M
Horská
Alena
A
Pomper
Martin G
MG
Chacko
Vaddapuram P
VP
Barker
Peter B
PB
D000328:Adult; D002552:Cerebral Ventricles / Q000378:metabolism*; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D002648:Child; D003067:Coenzymes / Q000172:deficiency; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008667:Metalloproteins / Q000172:deficiency; D000090006:Molybdenum Cofactors; D011522:Protons; D011621:Pteridines; D012640:Seizures / Q000175:diagnosis
D003067:Coenzymes; D008667:Metalloproteins; D000090006:Molybdenum Cofactors; D011522:Protons; D011621:Pteridines; C022261:molybdopterin