Combination therapy using sodium antimony gluconate in stearylamine-bearing liposomes against established and chronic Leishmania donovani infection in BALB/c Mice.
In this work we report the activity seen with combination therapy using sodium antimony gluconate in liposomes composed of egg phosphatidyl choline and stearylamine for elimination of Leishmania donovani parasites from the liver and spleen of BALB/c mice with established and chronic infections.
Infectious Diseases Group, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Rd., Calcutta 700032, India.
Swati
S
Pal
Rajesh
R
Ravindran
Nahid
N
Ali
D000818:Animals; D000967:Antimony Sodium Gluconate / Q000008:administration & dosage / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004337:Drug Carriers; D004351:Drug Resistance; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology; D008081:Liposomes; D008099:Liver / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010713:Phosphatidylcholines; D013154:Spleen / Q000469:parasitology
D000981:Antiprotozoal Agents; D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; D000967:Antimony Sodium Gluconate