Repeated sensory contact with aggressive mice rapidly leads to an anticipatory increase in core body temperature and physical activity that precedes the onset of aversive responding.
The present study investigated whether the 'psychological threat' induced by sensory contact with an aggressive conspecific would be a sufficient factor in inducing behavioural and physiological disturbances. Repeated sensory contact with an aggressive mouse (social threat) in a partitioned cage was compared with repeated exposure to a novel partitioned cage in male NMRI mice. We first examined parameters of stress responsiveness (body weight, plasma corticosterone levels, frequency of self-grooming and defecation). The temperature and physical activity responses to stress were also recorded during and after the 4 weeks of stress using radiotelemetry. Finally, cognitivo-emotional performance was assessed after acute stress and 2 and 4 weeks of stress by measuring decision making, sequential alternation performance and behaviour in the elevated T-maze. Social threat had a greater impact than novel cage exposure on most parameters of stress responsiveness, although mice did not habituate to either stressor. Social threat rapidly led to an anticipatory rise in core body temperature and physical activity before the scheduled stress sessions. Such anticipation developed within the first week and persisted for 9 days after ending the stress procedure. Some memory impairment in the sequential alternation test was found in stressed mice, independent of the stressor. After 4 weeks of stress, inhibitory avoidance in the elevated T-maze was enhanced in socially stressed mice and reduced in novel cage mice. The sustained anticipation of stress in the social threat group preceded aversive responding. It remains to be established whether anticipation contributes to the development of aversive responses.
Pardon
Marie-Christine
MC
Institute of Neuroscience, University of Nottingham Medical School, School of Biomedical Sciences, Queen's Medical Centre, Nottingham NG9 2UH, UK. marie.pardon@nottingham.ac.uk
Kendall
David A
DA
Pérez-Diaz
Fernando
F
Duxon
Mark S
MS
Marsden
Charles A
CA
D000374:Aggression / Q000502:physiology* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001831:Body Temperature / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D004924:Escape Reaction / Q000502:physiology; D006234:Handling, Psychological; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000502:physiology*; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology* / Q000523:psychology
D003345:Corticosterone