Mutactimycin PR, a new anthracycline antibiotic from Saccharothrix sp. SA 103. II. Physico-chemical properties and structure elucidation.
A new antibiotic termed mutactimycin PR (1) was isolated along with the known mutactimycin C (2) from the fermentation broth of Saccharothrix sp. SA 103. The two compounds belong to the anthracycline group. The structure of these antibiotics was elucidated with the aid of NMR and mass spectrometric investigations. The novel compound mutactimycin PR was characterized as 5,12 Naphtacenedione, 7-[(6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy]-4-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9 methyl.
Ecole Nationale Supérieure d'Agronomie de Toulouse, INPT, Laboratoire de Génie Chimique, UMR 5503 (CNRS/INPT/UPS), 1, avenue de l'Agrobiopôle, B.P. 107, F-31 326 Castanet-Tolosan Cedex, France.
Abdelghani
A
Zitouni
Florence
F
Mathieu
Yannick
Y
Coppel
Frederic
F
Pont
Nasserdine
N
Sabaou
Ahmed
A
Lebrihi
D039903:Actinobacteria / Q000737:chemistry* / Q000378:metabolism; D018943:Anthracyclines / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; C489302:mutactimycin PR