Vanadyl sulfate ameliorates insulin resistance and restores plasma dehydroepiandrosterone-sulfate levels in fructose-fed, insulin-resistant rats.
OBJECTIVE
To elucidate whether vanadyl sulfate ameliorates the decreased dehydroepiandrosterone sulfate (DHEAS) in hyperinsulinemic rats, we evaluated plasma DHEAS, insulin and triglyceride (TG) levels in fructose-induced, insulin-resistant rats.


METHODS
Animals were divided into three groups: control (C), fructose fed (F-F), and vanadyl-treated fructose fed (F-T). Control animals were fed with standard chow; F-F and F-T groups fed with 66% fructose diet. F-F and C groups received tap water; F-T group received water supplemented with 0.2 mg/ml vanadyl sulfate.


RESULTS
Fasting plasma glucose levels of three groups were comparable. Vanadyl treatment prevented the increase in plasma insulin and TG in the F-T group (P < 0.001) compared with the F-F group. Fructose feeding led to a decrease in plasma DHEAS in the F-F group (P < 0.001) compared with the C group. Vanadyl treatment prevented the decrease in plasma DHEAS in the F-T group (P < 0.001) compared with the F-F group.


CONCLUSIONS
Our results indicated that the hyperinsulinemia in fructose-fed, insulin-resistant rats is associated with low levels of DHEAS. Vanadyl sulfate probably restores plasma DHEAS, due to the improved insulin action.
Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. mharati@medinews.com
Mehdi
M
Harati
Mohsen
M
Ani
D000818:Animals; D001786:Blood Glucose / Q000096:biosynthesis; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005632:Fructose / Q000378:metabolism*; D006946:Hyperinsulinism / Q000378:metabolism; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D015233:Models, Statistical; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism; D017968:Vanadium Compounds / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D014280:Triglycerides; D017968:Vanadium Compounds; D005632:Fructose; D019314:Dehydroepiandrosterone Sulfate; C034028:vanadyl sulfate