Microdistributions of prospective BNCT-compound CuTCPH in tissue sections with a heavy ion microbeam.
Microdistributions of the prospective BNCT-compound CuTCPH, a carborane-containing tetraphenylporphyrin with one Cu atom in its molecular structure, have been obtained in tissue sections of different organs of tumor-bearing and normal Syrian hamsters injected with the boron compound by employing a heavy ion microbeam. High resolution X-ray spectroscopy following micro-PIXE (Particle Induced X-ray Emission with micrometer-sized beams) with a focused (16)O ion beam was used. Focusing was performed with a heavy-ion scanning high-precision magnetic quadrupole triplet microprobe. Squamous Cell Carcinomas were induced on the right Cheek Pouch of Syrian Hamsters (HCP), sampled, cryo-sectioned and freeze-dried. Two-dimensional maps of elemental concentration were obtained by scanning the beam over the samples. Very non-uniform Cu concentrations were found in all sections.
Departamento de Física, Argentine Atomic Energy Commission, CNEA, Av. Gral. Paz 1499, CP 1650, Bienos Aires, Villa Martelli, Argentina.
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P
Stoliar
A J
AJ
Kreiner
M E
ME
Debray
M E
ME
Caraballo
A A
AA
Valda
J
J
Davidson
M
M
Davidson
J M
JM
Kesque
H
H
Somacal
H
H
DiPaolo
A A
AA
Burlon
M J
MJ
Ozafrán
M E
ME
Vázquez
D
D
Minsky
E M
EM
Heber
V A
VA
Trivillin
A E
AE
Schwint
D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000532:radiotherapy; D002610:Cheek; D006224:Cricetinae; D008647:Mesocricetus; D008665:Metalloporphyrins / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D009062:Mouth Neoplasms / Q000378:metabolism / Q000532:radiotherapy; D013052:Spectrometry, X-Ray Emission; D014018:Tissue Distribution
D008665:Metalloporphyrins; C491007:copper tetracarboranyltetraphenylporphyrin