Hyalinizing spindle cell tumor with giant rosettes with pulmonary metastasis after a long hiatus: a case report.
Hyalinizing spindle cell tumor with giant rosettes (HSCTGR) is a recently described tumor, which is regarded as an unusual variant of low-grade fibromyxoid sarcoma. Proof of a metastatic potential was lacking. The patient in the report was a 35-yr-old woman who showed multiple bilateral pulmonary nodules with massive pleural effusion in the right side. She had a history of a mass excision in the right thigh 11 yrs ago at another hospital, which was reported as a "leiomyoma". Two years before this presentation, the patient received a routine chest radiograph which demonstrated bilateral multiple pulmonary nodules. A lobectomy of the left upper lung was performed. The histological findings revealed a well-circumscribed nodule that was characterized by a spindle-shaped fibrous to hyalinized stroma with criss-crossing short fascicles and giant collagen rosettes surrounded by a rim of spindle-shaped cells. Electron microscopy confirmed the fibroblastic nature of the tumor. This case, in addition to at least two other cases reported in the literature, demonstrates that the HSCTGR is a malignant neoplasm with the capacity to metastasize after a long hiatus.
Department of Clinical Pathology, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Eundeok
E
Chang
Anhi
A
Lee
Eunjung
E
Lee
Okran
O
Shin
Changsuk
C
Kang
Joon Mee
JM
Kim
Young Chae
YC
Chu
D000328:Adult; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D007723:Korea; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary* / Q000648:ultrastructure; D009362:Neoplasm Metastasis; D010996:Pleural Effusion / Q000473:pathology; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D013848:Thigh / Q000473:pathology; D013997:Time Factors