Lipid peroxidation and inguinal hernia repair. Tension-free vs. Andrews technique.
OBJECTIVE
To evaluate the early effect of inguinal hernia repair by the tension-free method compared to the conventional Andrew's technique on lipid peroxidation.


METHODS
Thirty-four patients subjected to elective hernia repair were enrolled in the study divided in two groups. Group A (n=18) underwent hernia repair by the tension-free method using a polypropylene mesh. Group B (n=16) underwent hernia repair by the Andrew's technique (i.e. a modification of the Bassini's technique). Venous blood samples were drawn preoperatively and at 12, 24 and 48 h postoperatively. Malondialdehyde (MDA) was estimated by the thiobarbiturate assay.


RESULTS
Neutrophil counts were significantly higher in patients of group B compared to group A at 12 and 48 h postoperatively. Concentrations of fibrinogen were similar between the two groups. MDA was significantly higher in patients of group B hours compared to group A at 12, 24 and 48 h postoperatively. Positive correlation was found between neutrophil counts and MDA at 12 h (r: +0.43, P: 0.015) and 48 h (r: +0.496, P: 0.005) but not at 24 h. No correlation was found between serum fibrinogen and MDA.


CONCLUSIONS
Hernia repair by the Andrews's technique elicits a sustained triggering of lipid peroxidation, compared to the tension-free method.
Department of Surgery, Aristotle University of Thessaloniki, Medical School, Fanariou 17 Kalamaria, 55133 Thessaloniki, Greece.
Basilios
B
Papaziogas
Ioannis M
IM
Koutelidakis
Evangelos J
EJ
Giamarellos-Bourboulis
Charalambos
C
Lazaridis
Vassilios
V
Koussoulas
Ioannis
I
Galanis
Helen
H
Giamarellou
Konstantinos
K
Atmatzidis
D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006552:Hernia, Inguinal / Q000097:blood* / Q000628:therapy*; D006801:Humans; D007958:Leukocyte Count; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D011126:Polypropylenes
D011126:Polypropylenes; D008315:Malondialdehyde; D005340:Fibrinogen