The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.
The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of TIM family, TIM-3 is selectively expressed on the surface of differentiated Th1 cells. TIM-3 might have an important role in the induction of autoimmune diseases by regulating macrophage activation and interacts with TIM-3 ligand to regulate Th1 responses. In the present study, we analyzed the association of the genotype and allele frequencies between rheumatoid arthritis (RA) patients and the controls without RA using large samples size at the -1516G>T, -574T>G and 4259G>T polymorphic sites of human Tim-3 gene. We further investigated the relationships between the genotypes of each single nucleotide polymorphisms (SNPs) and C-reactive protein (CRP) or rheumatoid factor (RF) levels in RA patients. The genotype and allele frequencies of the -574T>G (P = 0.001 and 0.001, respectively) as well as the 4259G>T (P = 0.001 ands 0.003, respectively) between RA patients and non-RA controls were significantly different. These results strongly suggest that -574T>G and 4259G>T polymorphism of the Tim-3 might be associated with susceptibility to RA.
Genome Research Center for Immune Disorders, Wonkwang University School of Medicine, Iksan, Chonbuk 570-749, Korea.
Soo-Cheon
SC
Chae
Young-Ran
YR
Park
Seung-Cheol
SC
Shim
Kyung-Sik
KS
Yoon
Hun-Taeg
HT
Chung
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D001483:Base Sequence; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D000072597:Hepatitis A Virus Cellular Receptor 2; D006801:Humans; D007723:Korea; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011991:Receptors, Virus; D012217:Rheumatoid Factor / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology
C448908:HAVCR2 protein, human; D000072597:Hepatitis A Virus Cellular Receptor 2; D008565:Membrane Proteins; D011991:Receptors, Virus; D002097:C-Reactive Protein; D012217:Rheumatoid Factor