Usefulness of magnifying endoscopic evaluation of the terminal ileum for a patient with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
The gastrointestinal tract is one of the common targets of acute graft-versus-host disease (GVHD), but accurate diagnosis is difficult because of the nonspecific nature of complicated diseases and the lack of diagnostic findings by conventional endoscopy. Recently, a magnifying endoscope has been developed and used for examining microstructures of the mucosa. Herein, we report the first use of a magnifying endoscope for a patient with gastrointestinal (GI) GVHD. Magnified endoscopic findings of atrophic and coalescent villi of the terminal ileum reflect histological findings of GVHD. Magnifying endoscopy of the terminal ileum may be useful for early detection and follow-up of GI GVHD.
Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan. masahiro.onozawa@nifty.ne.jp
Masahiro
M
Onozawa
Masakatsu
M
Yonezumi
Mitsuru
M
Kawarazaki
Koh
K
Izumiyama
Kouji
K
Chiba
Takeshi
T
Kondo
Shuichi
S
Ota
Sumiko
S
Kobayashi
Mototsugu
M
Kato
Satoshi
S
Hashino
Junji
J
Tanaka
Masahiro
M
Imamura
Masahiro
M
Asaka
D000293:Adolescent; D016145:Endoscopy, Digestive System / Q000379:methods*; D006086:Graft vs Host Disease / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007077:Ileal Diseases / Q000473:pathology; D007082:Ileum / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D014184:Transplantation, Homologous