Activities of dicationic compounds against Trichomonas vaginalis.
We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 microM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Services, U.S. Department of Health and Human Services, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724, USA.
Andrea L
AL
Crowell
Chad E
CE
Stephens
Arvind
A
Kumar
David W
DW
Boykin
W Evan
WE
Secor
D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D000994:Antitrichomonal Agents / Q000494:pharmacology*; D002412:Cations / Q000494:pharmacology*; D016054:DNA, Protozoan / Q000187:drug effects / Q000378:metabolism; D025141:Drug Resistance, Fungal; D009682:Magnetic Resonance Spectroscopy; D008795:Metronidazole / Q000494:pharmacology; D009593:Nitroimidazoles / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000994:Antitrichomonal Agents; D002412:Cations; D016054:DNA, Protozoan; D009593:Nitroimidazoles; D008795:Metronidazole