Moderated 252Cf neutron energy spectra in brain tissue and calculated boron neutron capture dose.
While there is significant clinical experience using both low- and high-dose (252)Cf brachytherapy, combination therapy using (10)B for neutron capture therapy-enhanced (252)Cf brachytherapy has not been performed. Monte Carlo calculations were performed in a brain phantom (ICRU 44 brain tissue) to evaluate the dose enhancement predicted for a range of (10)B concentrations over a range of distances from a clinical (252)Cf source. These results were compared to experimental measurements and calculations published in the literature. For (10)B concentrations </=50 microg/g, the (10)B neutron capture dose enhancement was small in comparison to the (252)Cf fast neutron dose.
Department of Radiation Oncology, Tufts-New England Medical Center #246, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA. mrivard@tufts-nemc.org
Mark J
MJ
Rivard
Robert G
RG
Zamenhof
D016754:Boron Neutron Capture Therapy / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D001918:Brachytherapy / Q000379:methods* / Q000706:statistics & numerical data; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002142:Californium / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D019047:Phantoms, Imaging; D011874:Radiometry / Q000706:statistics & numerical data; D011879:Radiotherapy Dosage
D002142:Californium