Tracheostomy timing and the duration of weaning in patients with acute respiratory failure.
BACKGROUND
The effect of various airway management strategies, such as the timing of tracheostomy, on liberation from mechanical ventilation (MV) is uncertain. We tested the hypothesis that tracheostomy, when performed prior to active weaning, does not influence the duration of weaning or of MV in comparison with a more selective use of tracheostomy.


METHODS
In this observational prospective cohort study, surgical patients requiring >or= 72 hours of MV were followed prospectively. Patients undergoing tracheostomy prior to any active weaning attempts (early tracheostomy [ET]) were compared with patients in whom initial weaning attempts were made with the endotracheal tube in place (selective tracheostomy [ST]).


RESULTS
We compared the duration of weaning, the total duration of MV and the frequency of fatigue and pneumonia. Seventy-four patients met inclusion criteria. Twenty-one patients in the ET group were compared with 53 patients in the ST group (47% of whom ultimately underwent tracheostomy). The median duration of weaning was shorter (3 days versus 6 days, P = 0.05) in patients in the ET group than in the ST group, but the duration of MV was not (median [interquartile range], 11 days [9-26 days] in the ET group versus 13 days [8-21 days] in the ST group). The frequencies of fatigue and pneumonia were lower in the ET group patients.


CONCLUSIONS
Determining the ideal timing of tracheostomy in critically ill patients has been difficult and often subjective. To standardize this process, it is important to identify objective criteria to identify patients most likely to benefit from the procedure. Our data suggest that in surgical patients with resolving respiratory failure, a patient who meets typical criteria for a trial of spontaneous breathing but is not successfully extubated within 24 hours may benefit from a tracheostomy. Our data provide a framework for the conduct of a clinical trial in which tracheostomy timing can be assessed for its impact on the duration of weaning.


CONCLUSIONS
Tracheostomy prior to active weaning may hasten liberation from ventilation and reduce complications. However, this does not reduce the overall duration of MV.
Boynton
Jackie H
JH
Department of Respiratory Care, Parkland Health and Hospital Systems, Dallas, Texas, USA.
Hawkins
Kenneth
K
Eastridge
Brian J
BJ
O'Keefe
Grant E
GE
D000208:Acute Disease; D000328:Adult; D000368:Aged; D003422:Critical Care / Q000379:methods*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000295:instrumentation* / Q000706:statistics & numerical data; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D015996:Survival Rate; D013997:Time Factors; D014139:Tracheostomy; D015300:Ventilator Weaning