Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia.
The present study evaluated the potential effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent, against the delayed neuronal death (DND) of hippocampal neurons an otherwise lethal ischemic insult. Pretreatment with single oral GGA (800 mg/kg, 2 days before ischemia) significantly attenuated DND in gerbil hippocampus. These effects of GGA were prevented by the coinjection of MK801, a noncompetitive N-methyl-d-aspartate glutamate receptor antagonist, which indicates that the protection was indeed glutamate receptor activation mediated.
Fujiki
Minoru
M
Department of Neurosurgery, School of Medicine, Oita University, 1-1, Idaigaoka, Hasama-machi, Oita 879-5593, Japan. fujiki@med.oita-u.ac.jp
Kobayashi
Hidenori
H
Inoue
Ryo
R
Tatsuya
Abe
A
Ishii
Keisuke
K
D000284:Administration, Oral; D000818:Animals; D016923:Cell Death / Q000187:drug effects*; D004224:Diterpenes / Q000008:administration & dosage*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004334:Drug Administration Schedule; D004336:Drug Antagonism; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D013997:Time Factors
D004224:Diterpenes; D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; C031049:geranylgeranylacetone