Characterization and expression of the human WNT4; lack of associated germline mutations in high--to moderate--risk breast and ovarian cancer.
Wnt4 is needed for correct development of several tissues in the mouse, and WNT4 is found here to be expressed in a temporal manner in human embryonic tissues. In addition, WNT4 mRNA is seen in several adult tissues. The 1.5 kb transcript is dominant in adult tissues, whereas the 2.4 kb transcript is the major one in embryonic tissues. The involvement of WNT4 in normal mammary gland and ovary development suggests that WNT4 germline mutations may be associated with the human cancer predisposition. Their absence in cancer families, however, implies lack of involvement of WNT4 mutations in the etiology of hereditary susceptibility to breast and ovarian cancer. Finally, the chromosomal location of WNT4 is narrowed to 1p36.12.
Peltoketo
Hellevi
H
Department of Biochemistry and Biocenter Oulu, Faculties of Science and Medicine, University of Oulu, Linnanmaa, P.O. Box 3000, FIN-90014, Oulu, Finland.
Allinen
Minna
M
Vuosku
Jaana
J
Kujala
Sonja
S
Lundan
Tuija
T
Salminen
Annamari
A
Winqvist
Robert
R
Vainio
Seppo
S
D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics*; D010375:Pedigree; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000096:biosynthesis*; D051153:Wnt Proteins; D060528:Wnt4 Protein
D011518:Proto-Oncogene Proteins; C555581:WNT4 protein, human; D051153:Wnt Proteins; D060528:Wnt4 Protein; C555582:Wnt4 protein, mouse