The essence of total synthesis.
For the past century, the total synthesis of natural products has served as the flagship of chemical synthesis and the principal driving force for discovering new chemical reactivity, evaluating physical organic theories, testing the power of existing synthetic methods, and enabling biology and medicine. This perspective article seeks to examine this time-honored and highly demanding art, distilling its essence in an effort to ascertain its power and future potential.
Nicolaou
K C
KC
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. kcn@scripps.edu
Snyder
Scott A
SA
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000266:history; D002625:Chemistry, Organic / Q000266:history; D002626:Chemistry, Pharmaceutical / Q000266:history; D049673:History, 20th Century; D015394:Molecular Structure
D001688:Biological Products