Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya.
Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4983, USA. moorms@cwru.edu
A M
AM
Moormann
P E
PE
Embury
J
J
Opondo
O P
OP
Sumba
J H
JH
Ouma
J W
JW
Kazura
C C
CC
John
D000293:Adolescent; D000328:Adult; D000368:Aged; D000531:Altitude; D002648:Child; D002675:Child, Preschool; D019353:Endemic Diseases; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology* / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007630:Kenya / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000453:epidemiology* / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D012111:Residence Characteristics; D012805:Sickle Cell Trait / Q000453:epidemiology* / Q000235:genetics
D006451:Hemoglobin, Sickle; C028671:hemoglobin AS