Pyridoxine as a template for the design of antiplatelet agents.
The B(6) vitamers have been shown to display beneficial therapeutic effects in cardiovascular related disorders. The design of novel antiplatelet agents using pyridoxine as a template has led to the discovery of a class of novel cardio- and cerebro-protective agents. The present study describes the synthesis of several of these derivatives along with the antiplatelet and antiischemic activity of derivative 16.
Zhang
Wenlian
W
Canam Bioresearch Inc., 6-1200 Waverley Street, Winnipeg, MB, Canada R3T 0P4.
Yao
John
J
Pham
Vinh
V
Whitney
Tara
T
Froese
Doug
D
Friesen
Albert
A
Stang
Linda
L
Xu
Chen
C
Shuaib
Ashfaq
A
Diakur
James M
JM
Haque
Wasim
W
D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D006801:Humans; D066298:In Vitro Techniques; D020767:Intracranial Thrombosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011736:Pyridoxine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013552:Swine
D010975:Platelet Aggregation Inhibitors; D011736:Pyridoxine