A systematic review of brachytherapy. Is it an effective and safe treatment for localised prostate cancer?
BACKGROUND
Brachytherapy is a promising treatment for prostate cancer as it may have reduced rates of impotence and incontinence.


OBJECTIVE
General practitioners can influence the treatment patients receive by their referral patterns, so it is important they understand the effectiveness and safety of treatment. We reviewed the primary literature on brachytherapy as sole therapy for localised prostate cancer.


CONCLUSIONS
Although there have been many studies on the safety and effectiveness of brachytherapy, there have been no trials of brachytherapy versus other treatments that would control for factors such as tumour stage, grade, or initial prostate specific antigen levels. Brachytherapy for localised prostate cancer appears to have equivalent survival rates to surgery and lower rates of impotence and urinary incontinence.
Doust
Jenny
J
Centre for General Practice, University of Queensland. j.doust@sph.uq.edu.au
Miller
Emma
E
Duchesne
Gillian
G
Kitchener
Michael
M
Weller
David
D
D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D007172:Erectile Dysfunction / Q000209:etiology; D005194:Family Practice / Q000379:methods; D006801:Humans; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome; D014525:Urethral Stricture / Q000209:etiology; D014549:Urinary Incontinence / Q000209:etiology; D016055:Urinary Retention / Q000209:etiology