Development tracks for cancer prevention markers.
We provide a general framework for describing various roles for biomarkers in cancer prevention research (early detection, surrogate endpoint, and cohort identification for primary prevention) and the phases in their evaluation.
Baker
Stuart G
SG
Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892-7354, USA. sb16i@nih.gov
Kramer
Barnett S
BS
Prorok
Philip C
PC
D014408:Biomarkers, Tumor / Q000032:analysis*; D015331:Cohort Studies; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*
D014408:Biomarkers, Tumor