Seroepidemiology of group C rotavirus infection in England and Wales.
A total of 3199 serum samples collected in 1993--1994 from two population cohorts from England and Wales were tested for the prevalence of IgG antibodies specifically directed against group C rotavirus VP6. Seroprevalence was 39% (95% confidence intervals: 37.0-40.4%). Seroprevalence was highest (46.0%) in the oldest age group (61-70 years of age). Infection with group C rotaviruses occurred at an earlier age and with higher incidence in rural than in urban populations. These results may suggest transmission from animals to humans, however further work is required to identify the reservoir of group C rotavirus for human infection.
Enteric Virus Unit, Enteric, Respiratory and Neurological Virus Laboratory, Health Protection Agency, London. Miren.Iturriza@hpa.org.uk
Miren
M
Iturriza-Gómara
Ian
I
Clarke
Ulrich
U
Desselberger
David
D
Brown
Daniel
D
Thomas
Jim
J
Gray
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity; D036022:Capsid Proteins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003710:Demography; D004739:England / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012401:Rotavirus / Q000145:classification / Q000276:immunology*; D012400:Rotavirus Infections / Q000453:epidemiology*; D016036:Seroepidemiologic Studies; D014852:Wales / Q000453:epidemiology
D000914:Antibodies, Viral; D036022:Capsid Proteins; D007074:Immunoglobulin G