Histologic behavior of the inflammatory process in autologous fat implantation in rabbit vocal folds.
Fat implantation in the vocal fold is described as a method of repairing vocal fold histostructural lesions that correlate with mucosal wave abnormalities. The aim of this study was to evaluate the histologic behavior of autologous fat implants. A fat block was implanted in pockets surgically created in the vocal folds of rabbits, and the inflammatory process induced was compared to the status of the contralateral vocal fold. Twenty-four rabbits were allocated into 3 groups to be sacrificed 1 week, 3 weeks, and 3 months after the implantation. The fat autograft did not cause any unexpected fibrosis, and we consider it a relatively safe material for implantation, with a low tendency to induce epithelial reaction and the ability to repair the histostructure of the vocal fold.
Duprat
André de Campos
Ade C
Department of Otorhinolaryngology, Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, Brazil.
Costa
Henrique Olival
HO
Lancelotti
Carmem
C
Ribeiro de Almeida
Roberta
R
Caron
Renata
R
D000273:Adipose Tissue / Q000637:transplantation*; D000818:Animals; D005355:Fibrosis; D007249:Inflammation / Q000473:pathology*; D008297:Male; D009336:Necrosis; D009389:Neovascularization, Pathologic; D011817:Rabbits; D014182:Transplantation, Autologous; D014827:Vocal Cords / Q000473:pathology* / Q000601:surgery*