Short-term sound temporal envelope characteristics determine multisecond time patterns of activity in human auditory cortex as shown by fMRI.
Functional magnetic resonance imaging (fMRI) of human auditory cortex has demonstrated a striking range of temporal waveshapes in responses to sound. Prolonged (30 s) low-rate (2/s) noise burst trains elicit "sustained" responses, whereas high-rate (35/s) trains elicit "phasic" responses with peaks just after train onset and offset. As a step toward understanding the significance of these responses for auditory processing, the present fMRI study sought to resolve exactly which features of sound determine cortical response waveshape. The results indicate that sound temporal envelope characteristics, but not sound level or bandwidth, strongly influence response waveshapes, and thus the underlying time patterns of neural activity. The results show that sensitivity to sound temporal envelope holds in both primary and nonprimary cortical areas, but nonprimary areas show more pronounced phasic responses for some types of stimuli (higher-rate trains, continuous noise), indicating more prominent neural activity at sound onset and offset. It has been hypothesized that the neural activity underlying the onset and offset peaks reflects the beginning and end of auditory perceptual events. The present data support this idea because sound temporal envelope, the sound characteristic that most strongly influences whether fMRI responses are phasic, also strongly influences whether successive stimuli (e.g., the bursts of a train) are perceptually grouped into a single auditory event. Thus fMRI waveshape may provide a window onto neural activity patterns that reflect the segmentation of our auditory environment into distinct, meaningful events.
Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. mharms@alam.mit.edu
Michael P
MP
Harms
John J
JJ
Guinan
Irina S
IS
Sigalovsky
Jennifer R
JR
Melcher
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001303:Auditory Cortex / Q000098:blood supply / Q000502:physiology* / Q000528:radiation effects; D001307:Auditory Perception / Q000502:physiology* / Q000528:radiation effects; D001931:Brain Mapping; D004307:Dose-Response Relationship, Radiation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000097:blood; D011930:Reaction Time / Q000502:physiology; D013016:Sound; D013997:Time Factors
D010100:Oxygen