Sonochemically fabricated microelectrode arrays for biosensors--part II. Modification with a polysiloxane coating.
A polymer-modified sonochemically fabricated glucose oxidase microelectrode array with microelectrode population densities of up to 2.5 x 10(5) microelectrodes per square centimetres is reported. These microelectrode sensors were formed by first depositing an insulating film on commercial screen printed electrodes which was subsequently sonicated to form cavities of regular sizes in the film. Electropolymerisation of aniline at the microelectrode cavities formed polyaniline protrusions containing entrapped glucose oxidase. Chemical deposition of polysiloxane from dichlorodimethysilane was used to deposit a thin protective and diffusion mass transport controlling coating over the electrodes. The physical and electrochemical properties of these films were studied. The performance of the final glucose oxidase based microelectrode sensor array is reported.
Manchester Materials Science Centre, University of Manchester, UMIST Grosvenor St, Manchester M1 7HS, UK.
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S
Myler
F
F
Davis
S D
SD
Collyer
S P J
SP
Higson
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004800:Enzymes, Immobilized / Q000032:analysis / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005947:Glucose / Q000032:analysis* / Q000737:chemistry*; D005949:Glucose Oxidase / Q000032:analysis / Q000737:chemistry*; D008420:Manufactured Materials; D008839:Microelectrodes; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012833:Siloxanes / Q000737:chemistry*; D013010:Sonication
D020099:Coated Materials, Biocompatible; D004800:Enzymes, Immobilized; D012833:Siloxanes; D005949:Glucose Oxidase; D005947:Glucose