YM-215343, a novel antifungal compound from Phoma sp. QN04621.
Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with MIC values of 2 to approximately 16 microg/ml. It also showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 microg/ml.
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8 Azusawa, Itabashi-ku, Tokyo 174-8511, Japan. shibazak@yamanouchi.co.jp
Mitsuyoshi
M
Shibazaki
Masatoshi
M
Taniguchi
Takako
T
Yokoi
Koji
K
Nagai
Masato
M
Watanabe
Kenichi
K
Suzuki
Tomoko
T
Yamamoto
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002850:Chromatography, Gel; D005285:Fermentation; D006367:HeLa Cells; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry / Q000378:metabolism*; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010944:Plants / Q000382:microbiology; D011728:Pyridones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000935:Antifungal Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D009281:Naphthalenes; D011728:Pyridones; C489306:YM-215343