Regulatory effect of dosiinpartner on high-fat diet-induced obesity in C57BL/6J mice.
Dosiinpartner (DSP) is a newly developed dietary functional food to help control weight. The aim of this study was to evaluate whether DSP combined with a high-fat (HF) diet could influence body weight, fat accumulation, and plasma glucose levels. Mice were fed for 8 weeks with normal diet, HF diet, and HF+10% or 20% DSP diet. Body weight was recorded at 1 week, and plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and glucose were analyzed at the end of the study. Weight increases in the 10% or 20% DSP group were significantly less than in the HF diet group (p<0.05). Plasma total cholesterol and LDL cholesterol levels decreased by 48.3% and 26.8% in the 10% DSP group and by 42.9% and 34.9% in the 20% DSP group, respectively. However, the HDL cholesterol level was unchanged. Glucose levels also decreased by 80.6% in the 10% DSP group but was almost the same in the HF and 20% DSP groups. Our findings indicate that DSP may be beneficial in the regulation of high-fat diet-induced overweight and other complications such as circulatory disorders and diabetes mellitus.
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.
Hyo-Jin
HJ
An
Hwan-Suck
HS
Chung
Nyeon-Hyoung
NH
An
Rae-Kil
RK
Park
Sung-Hoon
SH
Kim
Cheorl-Ho
CH
Kim
Yun-Kyung
YK
Kim
Hyung-Min
HM
Kim
Seung-Heon
SH
Hong
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D005502:Food; D008111:Liver Function Tests; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000517:prevention & control*
D001786:Blood Glucose; D004041:Dietary Fats; D002784:Cholesterol