[Inhibition of river clam extract LX01 on human lung epithelial carcinoma cell line A549].
OBJECTIVE
To explore the inhibition effect of river clam extract LX01 on human lung epithelial carcinoma (A549) in mice.


METHODS
The inhibition ratio of LX01 on A549 was detected by MTT method. A549 was inoculated into BALB/c mice, and 2 days later, LX01 (50, 100, 200 mg/kg.d) or cytoxan (0.02 mg/kg.d) were administrated for 15 days. Tumor weight, survival time and leukocyte count were measured.


RESULTS
Tumor growth was markedly inhibited by LX01 in a dose- dependent manner. LX01 could significantly extend the survival time compared with the control group (P<0.01), but LX01 did not reduce leukocyte count of mice transplanted with A549.


CONCLUSIONS
LX01 could efficiently inhibit the growth of A549 transplanted into mice and maintain the normal immunological function.
Wang
Shun-guan
SG
Department of Oncology, Second People's Hospital of Guangdong Province, Guangzhou 510317, China.
Li
Lin
L
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D049872:Bivalvia / Q000737:chemistry*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014020:Tissue Extracts / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014020:Tissue Extracts