Intrabodies as therapeutic agents.
In the past decade, a large number of intracellular antibodies (intrabodies) have been developed for potential use as therapeutic agents. As antibodies can be generated against virtually any target antigen, the applications of intrabodies span a wide range including tumour therapy, infectious diseases, transplantation, and other diseases associated with protein overexpression or mutagenesis. This article summarises the development of intrabodies and their applications as therapeutic agents.
Kontermann
Roland E
RE
Vectron therapeutics AG, Rudolf-Breitscheid-Str. 24, 35037 Marburg, Germany. kontermann@vectron-ag.com
D000818:Animals; D000890:Anti-Infective Agents / Q000276:immunology / Q000627:therapeutic use; D000906:Antibodies / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000276:immunology / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007424:Intracellular Fluid / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism
D000890:Anti-Infective Agents; D000906:Antibodies; D000970:Antineoplastic Agents