Kinetics of immune parameters in a patient with sepsis caused by Streptococcus pyogenes treated with activated protein C.
We report a case of streptococcal sepsis treated with recombinant human activated protein C (rhAPC). High plasma IL-6 and cortisol levels at baseline significantly decreased 24 h following the infusion of rhAPC. This decrease was accompanied by a rise of circulating lymphocyte subsets. Our observation may be due to immunomodulatory properties of rhAPC.
Holub
Michal
M
Third Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague, Czech Republic. michal.holub@fnb.cz
Helcl
Miroslav
M
Beran
Ondrej
O
Hnyková
Jarmila
J
Príhodová
Jana
J
D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007700:Kinetics; D008875:Middle Aged; D011486:Protein C / Q000008:administration & dosage / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology* / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000276:immunology* / Q000382:microbiology; D013297:Streptococcus pyogenes; D016896:Treatment Outcome
D015850:Interleukin-6; D011486:Protein C; D011994:Recombinant Proteins; D006854:Hydrocortisone