Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer.
BACKGROUND
The RNASEL G1385A variant was recently found to be implicated in the development of prostate cancer. Considering the function of RNase L and the pleiotropic effects of mutations associated with cancer, we sought to investigate whether the RNASEL G1385A variant is a risk factor for breast cancer.


METHODS
A total of 453 breast cancer patients and 382 age- and sex-matched controls from Greece and Turkey were analyzed. Genotyping for the RNASEL G1385A variant was performed using an Amplification Refractory Mutation System (ARMS).


RESULTS
Statistical evaluation of the RNASEL G1385A genotype distribution among breast cancer patients and controls revealed no significant association between the presence of the risk genotype and the occurrence of breast cancer.


CONCLUSIONS
Although an increasing number of studies report an association between the RNASEL G1385A variant and prostate cancer risk; this variant does not appear to be implicated in the development of breast cancer.
Sevinç
Akin
A
Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.
Yannoukakos
Drakoulis
D
Konstantopoulou
Irene
I
Manguoglu
Esra
E
Lüleci
Güven
G
Colak
Taner
T
Akyerli
Cemaliye
C
Colakoglu
Gülsen
G
Tez
Mesut
M
Sayek
Iskender
I
Gerassimos
Voutsinas
V
Nasioulas
George
G
Papadopoulou
Eirene
E
Florentin
Lina
L
Kontogianni
Elena
E
Bozkurt
Betül
B
Kocabas
Neslihan Aygün
NA
Karakaya
Ali Esat
AE
Yulug
Isik G
IG
Ozçelik
Tayfun
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001943:Breast Neoplasms / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics; D004722:Endoribonucleases / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors
D004273:DNA, Neoplasm; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease