Chlamydia pneumoniae IgA seropositivity and sudden sensorineural hearing loss.
A prospective study was designed to evaluate a possible role of an endured infection with Chlamydia pneumoniae or Chlamydia trachomatis as a cause for sudden sensorineural hearing loss. For this in 60 patients with a first episode of a sensorineural hearing loss and-60 sex-matched and aged-matched controls, following a complete otoneurological diagnosis blood tests for IgA, IgM and IgG with regard to Chlamydia pneumoniae and trachomatis were evaluated. We found a statistically significant higher prevalence of IgA positivity of Chlamydia pneumoniae in patients with sudden sensorineural hearing loss (chi2-test, p < 0.017). For this, Chlamydia pneumoniae may be a possible cause for sudden sensorineural hearing loss. A targeted antibiotic therapy, as it has been discussed for myocardial infarction, might possibly open an additional treatment option for sudden sensorineural hearing loss.
Department of Otorhinolaryngology, Head and Neck Surgery, Philipps-University, Marburg.
Anja A
AA
Dünne
Anette
A
Wiegand
Helge
H
Prinz
W
W
Slenczka
Jochen A
JA
Werner
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002692:Chlamydia trachomatis / Q000276:immunology*; D023521:Chlamydophila Infections / Q000150:complications* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D005260:Female; D005858:Germany; D006319:Hearing Loss, Sensorineural / Q000382:microbiology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M