Perspectives in chronic lymphocytic leukemia biology and management.
Considerable progress has been achieved in the comprehension of the pathogenesis, prognosis, assessment, and treatment of chronic lymphocytic leukemia. However, this progress also has introduced new enigmas in the fields of biology, prognosis, and treatment. This article discusses some unanswered questions in these different topics.
Dighiero
Guillaume
G
Unité d'Immuno-Hématologie et d'Immunopathologie, Institut Pasteur, 28 rue du Dr Roux F-75724 Paris cedex 15, France. dighiero@pasteur.fr
D005803:Genes, Immunoglobulin; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D011379:Prognosis