Antiproliferative constituents in plants 14. Coumarins and acridone alkaloids from Boenninghausenia japonica NAKAI.
The MeOH extracts of the ground part and the root of Boenninghausenia japonica NAKAI showed inhibitory activity against tumor cell growth. Fractionation of the extracts has resulted in isolation of 1,3-dihydroxy-4-(2'-hydroxy-3'-hydroxymethyl-3',4'-epoxy-butyl)-N-methylacridone, 1,3-dihydroxy-4-[(Z)-3'-hydroxy-3'-methyl-buten-1'-yl]-N-methylacridone, 3-(1',1'-dimethylallyl)-7-hydroxy-8-methoxy-2H-1-benzopyran-2-one, casegravol, cis-casegravol, and edgeworin in addition to 9 compounds reported from B. japonica and B. albiflora. The isolates from this plant and some related compounds were tested for antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.
Chaya
Norihito
N
Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Terauchi
Kazuko
K
Yamagata
Yuriko
Y
Kinjo
Junei
J
Okabe
Hikaru
H
D000166:Acridines / Q000302:isolation & purification / Q000494:pharmacology*; D054831:Acridones; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D010944:Plants / Q000737:chemistry*
D000166:Acridines; D054831:Acridones; D000470:Alkaloids; D003374:Coumarins; C041300:acridone