Phototoxic effects of topical azelaic acid, benzoyl peroxide and adapalene were not detected when applied immediately before UVB to normal skin.
The enhancing effects on UVB erythema of topical agents applied on sun exposed areas are important due to their increased sunburn risk. Since the lesions in acne vulgaris are seen primarily on the face, the effects of topical agents used in acne treatment on the erythemogenicity of UVB is important. The aim of the present study was to examine whether azelaic acid cream, benzoyl peroxide gel, adapalene gel have the enhancing effects on UVB erythema which are widely used in the topical treatment of acne vulgaris. The minimal erythema dose (MED) was determined with phototest in 30 volunteers and the test was repeated with thin (0.1 cc/25 cm(2)) and thick (0.3 cc/25 cm(2)) azelaic acid cream, benzoyl peroxide gel, adapalene gel. The effects of each agent on MED was determined after 24 hours. MEDs of UVB were unaffected by azelaic acid cream, benzoyl peroxide gel and adapalene gel when applied immediately before irradiation. According to our results azelaic acid, benzoyl peroxide and adapalene do not seem to have enhancing effects on UVB erythema and thus increased sunburn risk.
Dokuz Eylül Universitesi Tip Fakültesi Dermatoloji Anabilim Dali Inciraltý, 35340, Izmir, Türkiye.
Salih
S
Cetiner
Turna
T
Ilknur
Sebnem
S
Ozkan
D000152:Acne Vulgaris / Q000188:drug therapy; D000068816:Adapalene; D000279:Administration, Cutaneous; D001585:Benzoyl Peroxide / Q000494:pharmacology / Q000627:therapeutic use; D003998:Dicarboxylic Acids / Q000494:pharmacology / Q000627:therapeutic use; D004890:Erythema / Q000517:prevention & control; D006801:Humans; D007641:Keratolytic Agents / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology / Q000627:therapeutic use; D016037:Single-Blind Method; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D003998:Dicarboxylic Acids; D007641:Keratolytic Agents; D009281:Naphthalenes; D000068816:Adapalene; C010038:azelaic acid; D001585:Benzoyl Peroxide