Dimensional complexity of the neuronal activity in a rat model of depression.
The Flinders sensitive line of rats is a widely accepted and validated model of depression. These rats demonstrate abnormalities in limbic dopamine neurotransmission, suggesting disturbed neuronal activity in the ventral tegmental area. Interspike interval time-series were recorded from the ventral tegmental area of control Sprague-Dawley and Flinder sensitive line rats. These data were analyzed using standard measures (mean firing rate, bursting activity and spectral analysis) as well as the pointwise correlation dimension, a nonlinear measurement characterizing the complexity degree of dynamic systems. Pointwise correlation dimension, but not standard analysis revealed a significant difference between the animal lines. Our results suggest that nonlinear analyses can detect dysregulation of the mesolimbic dopaminergic system and shed light on the pathophysiology of depression.
Dremencov
Eliyahu
E
Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Nahshoni
Eitan
E
Levy
Dino
D
Mintz
Matti
M
Overstreet
David H
DH
Weizman
Abraham
A
Yadid
Gal
G
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003863:Depression / Q000503:physiopathology*; D004195:Disease Models, Animal; D004594:Electrophysiology / Q000379:methods; D008297:Male; D009474:Neurons / Q000502:physiology*; D017711:Nonlinear Dynamics; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D013057:Spectrum Analysis; D017557:Ventral Tegmental Area / Q000473:pathology*