Mitochondrial alterations in muscle biopsies of patients on statin therapy.
Clinical and biopsy study of nine patients on statin therapy suffering from various myopathic syndromes is reported. Biopsy findings showed non specific myopathic signs and mitochondrial changes, such as subsarcolemmal accumulation, morphological alterations, lipid increase and Cox-negative fibers. These findings confirm that statins may cause muscle damage and impair oxidative metabolism.
Department of Neurological and Behavioural Sciences, University of Siena, Siena, Italy.
S
S
Gambelli
M T
MT
Dotti
A
A
Malandrini
M
M
Mondelli
M L
ML
Stromillo
C
C
Gaudiano
A
A
Federico
D000328:Adult; D000368:Aged; D001706:Biopsy; D004594:Electrophysiology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000648:ultrastructure; D018485:Muscle Fibers, Skeletal / Q000187:drug effects* / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012508:Sarcolemma / Q000187:drug effects / Q000648:ultrastructure
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors