The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis.
A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important for virulence of M. tuberculosis.
Division of Mycobacterial Research, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
Cristiane C
CC
Frota
K G
KG
Papavinasasundaram
Elaine O
EO
Davis
M Joseph
MJ
Colston
D000818:Animals; D051777:AraC Transcription Factor; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001853:Bone Marrow / Q000382:microbiology; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008168:Lung / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*; D014774:Virulence
D051777:AraC Transcription Factor; D001426:Bacterial Proteins; D012097:Repressor Proteins; D014157:Transcription Factors