The effectiveness of rhBMP-2 in replacing autograft: an integrated analysis of three human spine studies.
In anterior lumbar spinal fusion, patients treated with rhBMP-2 on a collagen sponge carrier had statistically superior outcomes compared to patients treated with autogenous bone graft. A collagen sponge carrier should replace autogenous bone graft for this patient population.
Burkus
J Kenneth
JK
The Hughston Clinic, Columbus, GA, USA.
Heim
Stephen E
SE
Gornet
Matthew F
MF
Zdeblick
Thomas A
TA
D016063:Blood Loss, Surgical; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D016025:Bone Transplantation; D006305:Health Status Indicators; D006801:Humans; D007085:Ilium / Q000601:surgery; D007902:Length of Stay; D010147:Pain Measurement; D013123:Spinal Fusion / Q000379:methods*; D016212:Transforming Growth Factor beta; D014182:Transplantation, Autologous
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta