A novel crosslinkable polymer as drug-loaded coating for biomedical device.
A novel copolymer has been synthesized by the radical polymerization of poly (ethylene oxide) methacrylate, stearyl methacrylate, hydroxypropyl methacrylate and trimethoxysilylpropyl methacrylate. The polymer was characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy and gel permeation chromatography. The crosslinkable coating was prepared by dip-coating 5mg/ml solution in tetrahydrofuran onto glass substrate. A stable crosslinked coating was obtained after curing the coating at 70 degrees C for 9 h. Contact angle results indicated the possible reorganization of the surface amphiphilic molecule which interpreted the excellent biocompatibility revealed by the results of the platelet adhesion and plasma recalcification time. Rhodamine S and Cibacron Blue were used as model drugs to prepare drug-containing coating at the same conditions. Drug-releasing curves indicated that the mechanism of the release is approximately Fickian release.
Xu
Jian-Ping
JP
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. jianji@mail.hz.zj.cn
Ji
Jian
J
Chen
Wei-Dong
WD
Zhao
Hui-Fang
HF
Shen
Jia-Cong
JC
Fan
De-Zeng
DZ
Sun
Yu-Fu
YF
D001777:Blood Coagulation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology*; D003432:Cross-Linking Reagents; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010973:Platelet Adhesiveness / Q000187:drug effects / Q000502:physiology*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013608:Tablets, Enteric-Coated / Q000737:chemistry / Q000494:pharmacology
D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D013608:Tablets, Enteric-Coated