[Inductively coupled plasma and clinical biology. Toxicological applications].
The multi-elementary quantitation method using inductively coupled plasma mass spectrometry has been widely developed for use with biological fluids. Many elements can be quantified simultaneously in biological fluids, including: Li, Be, B, Al, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Pd, Cd, Sn, Sb, Te, Ba, W, Pt, Hg, Tl, Pb, Bi, U. The validation procedure is described by the French Society of Clinical Biology. Results for urine are corrected after creatinine determination. We report applications in clinical toxicology and forensic toxicology. Advances in inductively coupled plasma mass spectrometry in the field of clinical biology are particularly important for toxicological analysis. This powerful tool is helpful for better patient care and for the search for cause of death.
Goullé
J-P
JP
Laboratoire de pharmacocinétique et de toxicologie cliniques, Groupe hospitalier du Havre, BP 24, F76083 Le Havre Cedex. jgoulle@ch-havre.fr
Mahieu
L
L
Lainé
G
G
Lacroix
C
C
Clarot
F
F
Vaz
E
E
Proust
B
B
D000328:Adult; D020261:Arsenic Poisoning / Q000175:diagnosis; D001826:Body Fluids / Q000737:chemistry*; D005260:Female; D005554:Forensic Medicine; D006801:Humans; D007855:Lead Poisoning / Q000175:diagnosis; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D013324:Strontium / Q000506:poisoning; D014116:Toxicology / Q000295:instrumentation*
D013324:Strontium