Multifocal acquired demyelinating sensory and motor neuropathy: report of a case and review of the literature.
Multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy is characterized by an asymmetric multifocal pattern of motor and sensory loss, and conduction block and other features of demyelination in nerve conduction studies. MADSAM neuropathy needs to be differentiated from chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). In classic CIDP, there are symmetric proximal and distal weakness, sensory deficit in both upper and lower extremities and reduced deep tendon reflex. In MMN, limb weakness without sensory loss is asymmetric in the distribution of individual peripheral nerves and the weakness typically begins in the distal upper extremities. We report one patient with chronic progression of asymmetric numbness and weakness in four extremities. MADSAM neuropathy was diagnosed after extensive clinical and laboratory evaluations. It is very important to distinguish between CIDP, MADSAM neuropathy, and MMN by clinical, laboratory, and histological features because of different effective therapeutic strategies.
Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
Yu-Wan
YW
Yang
Chung-Hsiang
CH
Liu
Chon-Haw
CH
Tsai
Cheng-Chun
CC
Lee
Shuo-Bin
SB
Jou
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000473:pathology*; D003937:Diagnosis, Differential; D004558:Electric Stimulation; D004594:Electrophysiology; D006801:Humans; D008297:Male; D018908:Muscle Weakness / Q000188:drug therapy / Q000209:etiology; D009431:Neural Conduction; D011115:Polyneuropathies / Q000188:drug therapy / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D012018:Reflex / Q000502:physiology; D012678:Sensation Disorders / Q000209:etiology; D013624:Taiwan
D000893:Anti-Inflammatory Agents; D011239:Prednisolone