[Serotonin transporter gene polymorphism in irritable bowel syndrome].
OBJECTIVE
To investigate the association of serotonin transporter (SERT) gene polymorphism with irritable bowel syndrome (IBS).


METHODS
The VNTRs and 5-HTTLPR polymorphism of SERT gene was assessed with polymerase chain reaction in 81 patients with IBS and 48 healthy subjects(HS).


RESULTS
Compared with HS, IBS patients have a greater frequency of STin2.12/10 genotype in VNTRs region and a smaller frequency of STin2.12/12 genotype, however no significant difference was found in polymorphism of this region among the patients with C-IBS, D-IBS and A-IBS. We also found that the 5-HTTLPR allele L/L genotype occurred with greater frequency in C-IBS patients than in other two subgroups, whereas the L/S genotype occurred with smaller frequency in C-IBS. The frequency of association between 12/12 genotype and L/L genotype (12/12-L/L) in C-IBS was significantly higher than those in A-IBS and HS.


CONCLUSIONS
The presence of STin2.12/10 genotype may be correlated with IBS. The presence of L/L genotype and 12/12-L/L genotype association in IBS patients carries an increased risk of C-IBS, whereas the presence of the L/S genotype carries an increased risk of D-IBS and A-IBS.
Wang
Bang-mao
BM
Department of Gastroenterology, Tianjin Medical University Hospital, Tianjin 300052, China. bmwang@mail.zlnet.com.cn
Wang
Yu-ming
YM
Zhang
Wei-ming
WM
Zhang
Qing-yu
QY
Liu
Wen-tian
WT
Jiang
Kui
K
Zhang
Jie
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000235:genetics*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins
D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins