[Medical and medico-social case management of drug-resistant partial epilepsy. Specific implementation of long-term antiepileptic treatment in the adult].
Medical treatment of refractory localisation-related epilepsies in adults should always be considered with regard to surgical possibilities. When long-term therapy with antiepileptic drugs is necessary, the treatment tries to achieve maximal efficacy with the lowest unavoidable toxicity. Until an evidence-based choice can be made, the management is currently based on empirical knowledge. In this article, the available literature on effectiveness and monitoring of long term antiepileptic therapy is reviewed.
Service de Neurologie, Neuropsychologie et Explorations fonctionnelles des épilepsies, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France. chassagnon.serge@wanadoo.fr
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D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D019090:Case Management; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D015897:Comorbidity; D000529:Complementary Therapies; D016527:Drug Costs; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology / Q000628:therapy; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008607:Intellectual Disability / Q000453:epidemiology; D008297:Male; D019635:Neurosurgical Procedures; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D012959:Socioeconomic Factors; D016896:Treatment Outcome
D000927:Anticonvulsants