The dynamics of acute inflammation.
When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as sepsis and can culminate in organ failure and death. We consider a three-dimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and parameters. We analyze the various bifurcations between the different outcomes when key parameters are changed and suggest various therapeutic strategies. We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach.
Departments of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Rukmini
R
Kumar
Gilles
G
Clermont
Yoram
Y
Vodovotz
Carson C
CC
Chow
D000208:Acute Disease; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D007108:Immune Tolerance; D018448:Models, Immunological; D012008:Recurrence; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology*
D000893:Anti-Inflammatory Agents