Genetic analysis of synaptic target recognition and assembly.
Formation of synapses by neurons onto specific targets is essential to the function of a nervous system. The isolation and analysis of Caenorhabditis elegans and Drosophila mutants with synaptogenesis defects has provided insight into the functions of evolutionarily conserved molecules at single-synapse resolution. Importantly, such studies have uncovered novel molecules and signaling mechanisms. Here, recent progress on synaptic target recognition and synaptic assembly are reviewed.
Ackley
Brian D
BD
Department of Molecular, Cell and Developmental Biology, Howard Hughes Medical Institute, University of California, Santa Cruz, CA 95064, USA.
Jin
Yishi
Y
D000818:Animals; D017173:Caenorhabditis elegans; D002450:Cell Communication / Q000235:genetics*; D004330:Drosophila; D008959:Models, Neurological; D008967:Molecular Biology / Q000379:methods; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D013569:Synapses / Q000235:genetics*; D009435:Synaptic Transmission / Q000235:genetics*; D025801:Ubiquitin / Q000502:physiology
D011956:Receptors, Cell Surface; D025801:Ubiquitin