Enhanced blood boron concentration estimation for BPA-F mediated BNCT.
The blood boron concentration regulates directly the BNCT irradiation time in which the prescribed dose to the patient is delivered. Therefore a proper estimation of the blood boron concentration for the treatment field based on the measured blood samples before irradiation is required. The bi-exponential model fit using Levenberg-Marquardt method was implemented for this purpose to provide the blood boron concentration estimates directly to the treatment data flow during the BNCT procedure. The harmonic mean bi-exponential decay half-lives of the studied patient data (n=28) were 15+/-8 and 320+/-70 min for the faster and slower half-life. The model uncertainty (n=28) was reasonably low, 0.7+/-0.1 microg/g (about 5%). The implemented algorithm provides a robust method for temporal blood boron concentration estimation for BPA-F mediated BNCT. Utilization of the infusion data improves the reliability of the estimate. The overall data flow during the treatment fulfills the practical requirements concerning the BNCT procedure.
Kortesniemi
M
M
HUS Helsinki Medical Imaging Center, University of Helsinki, POB 340, FIN-00029 HUS, Finland. mika.kortesniemi@hus.fi
Seppälä
T
T
Auterinen
I
I
Savolainen
S
S
D000465:Algorithms; D001895:Boron / Q000097:blood*; D001896:Boron Compounds / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods / Q000706:statistics & numerical data; D005387:Finland; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000097:blood / Q000532:radiotherapy
C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D005632:Fructose; D001895:Boron