PMEA coating of pump circuit and oxygenator may attenuate the early systemic inflammatory response in cardiopulmonary bypass surgery.
We investigated the effects of coating a cardiopulmonary bypass (CPB) circuit and oxygenator with poly-2-methoxy-ethyl acrylate (PMEA) on the systemic inflammatory response during and after CPB. Thirty patients undergoing elective cardiac surgery were randomized into three groups (each group n = 10): noncoated (group N), heparin coated (group H), and PMEA coated circuit and oxygenator (group X). Bradykinin (BK), complement 3 activation (C3a) and interleukin-6 (IL-6) levels were measured as early phase indicators of inflammatory response, as were maximum C reactive proteins (CRP) and white blood cell (WBC) levels. The alveolar-arterial oxygen gradient (A-a DO2) was measured as a parameter of respiratory function. IL-6 levels after CPB were significantly higher in group N than in groups H and X (p < 0.05). Serum BK and C3a levels showed similar patterns in all groups. A-a DO2 was lower at the end of and 3 hours after CPB in groups H and X than in group N (p < 0.05). Maximum CRP levels were lower in group X than in groups N (p < 0.05). This prospective study suggests that PMEA coated CPB may improve respiratory function and decrease systemic inflammatory response after cardiac surgery, possibly because this circuit is as biocompatible as heparin coated CPB circuit.
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-Ku, Kyoto, Japan.
K
K
Ueyama
K
K
Nishimura
T
T
Nishina
T
T
Nakamura
T
T
Ikeda
M
M
Komeda
D000179:Acrylates; D000328:Adult; D000368:Aged; D001158:Arteries; D001920:Bradykinin / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible; D015926:Complement C3a / Q000378:metabolism; D005112:Extracorporeal Circulation; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D011108:Polymers; D011184:Postoperative Period; D011446:Prospective Studies; D011650:Pulmonary Alveoli; D012119:Respiration; D018746:Systemic Inflammatory Response Syndrome / Q000517:prevention & control*; D013997:Time Factors
D000179:Acrylates; D020099:Coated Materials, Biocompatible; D015850:Interleukin-6; D011108:Polymers; C413485:poly(2-methoxyethylacrylate); D015926:Complement C3a; D002097:C-Reactive Protein; D010100:Oxygen; D001920:Bradykinin