Immune reconstitution inflammatory syndrome associated with HIV and leprosy.
BACKGROUND
Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction to an opportunistic infection that occurs in human immunodeficiency virus (HIV)-positive patients with profound immunosuppression during the reconstitution of the immune system in the initial months of highly active antiretroviral treatment.


METHODS
We describe 3 cases of leprosy occurring in patients treated with a combination of 3 antiretroviral drugs who fulfilled the criteria for IRIS. A reactional state occurred in all 3 cases. Two of the 3 patients presented an unusual ulcerous progression of the lesions not generally observed in cases of leprosy. The outcome was favorable in all 3 cases. The frequency of IRIS associated with leprosy in French Guiana and Martinique is estimated at 3 cases per 1000 HIV-positive patients receiving highly active antiretroviral treatment.


CONCLUSIONS
Leprosy should be recognized as an IRIS-associated infection with possibility of atypical presentation.
Institut Guyanais de Dermatologie Tropicale, Service de Dermatologie, Centre d'Information et de Soins de l'Immunodéficience Humaine de Guyane, Centre Hospitalier de Cayenne, French Guiana. couppie.pierre@voila.fr
Pierre
P
Couppié
Sylvie
S
Abel
Hélène
H
Voinchet
Morgane
M
Roussel
Raymond
R
Hélénon
Michel
M
Huerre
Dominique
D
Sainte-Marie
André
A
Cabié
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage; D007918:Leprosy / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged
D019380:Anti-HIV Agents; D007917:Leprostatic Agents