Role of oxidative stress enzymes in open-angle glaucoma.
OBJECTIVE
To investigate the role of oxidative stress and lipid peroxidation in the pathogenesis of primary open-angle glaucoma (POAG).


METHODS
The activities of myeloperoxidase (MPO), catalase (CAT), and the levels of plasma malondialdehyde (MDA) were measured in 40 (15 men and 25 women) patients with POAG and 60 (30 men and 30 women) healthy controls.


RESULTS
There was no significant difference in the activities of CAT and MPO between the POAG patients and the controls. However, the plasma MDA level was significantly higher in patients than the controls.


CONCLUSIONS
The results of this preliminary study suggest that the possible alterations of plasma MDA levels may be associated with the pathogenesis of POAG, but further research is needed to understand the role of oxidative damage in this important disorder of aging.
Department of Ophthalmology, Mersin University, Faculty of Medicine, Mersin, Turkey. dryildirimoz@hotmail.com
O
O
Yildirim
N A
NA
Ateş
B
B
Ercan
N
N
Muşlu
A
A
Unlü
L
L
Tamer
U
U
Atik
A
A
Kanik
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood
D015415:Biomarkers; D008315:Malondialdehyde; D002374:Catalase; D009195:Peroxidase