Both expansion of regulatory GR1+ CD11b+ myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis.
Oral infection with Toxoplasma gondii leads to transient systemic hyporesponsiveness. In this report, we characterized the presence in the lungs of GR1(+) CD11b(+) myeloid cells that have potent nitric oxide-dependent immunoregulatory properties. We also demonstrated the interleukin 2-reversible anergy of both pulmonary CD8(+) and CD4(+) activated T lymphocytes with infection.
UMR Université-INRA 483 Immunologie Parasitaire et Vaccinologie, UFR des Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France.
Mathieu-Benoît
MB
Voisin
Dominique
D
Buzoni-Gatel
Daniel
D
Bout
Florence
F
Velge-Roussel
D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D039481:CD11b Antigen / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000166:cytology / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D023461:Myeloid Progenitor Cells / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014122:Toxoplasma / Q000276:immunology / Q000472:pathogenicity*; D014124:Toxoplasmosis, Animal / Q000276:immunology* / Q000469:parasitology
D039481:CD11b Antigen