Serum transforming growth factor-beta1(TGF-beta1) in patients with cirrhosis, chronic hepatitis B and chronic hepatitis C [corrected].
Chronic liver disease and cirrhosis are two of the most important health problems according to current gastroenterology literature. Based on the recent developments in the field of immunology, advanced follow-up and treatment modalities have been introduced for these disorders. Immune defence against viral infections depends on effective cellular immune responses derived mainly from Th1-related cytokines. Th2 type immune responses can inhibit efficient immune function by secretion of several cytokines such as IL-10, TGF-beta1. In this particular study, we determined the serum levels of TGF-beta1, which plays a role in immune suppression and induction of tissue fibrosis. We evaluated the role of TGF-beta1 in the pathogenesis of chronic liver disease and cirrhosis. Fourteen chronic hepatitis B (CHB), 12 chronic hepatitis C (CHC) patients and 21 cirrhotic patients were enrolled in the study. The control group consisted of ten healthy people. Serum TGF-beta1 levels were higher in both cirrhosis and CHC group when compared to those in CHB and control groups (P < 0.05). Although serum TGF-beta1 levels in the cirrhosis group were higher than that in the CHC group, the difference was not statistically significant. In conclusion, elevated TGF-beta1 levels in patients with CHC and cirrhosis may have a role in the pathogenesis and chronicity of these diseases.
Celal Bayar University, Medical Faculty, Department of Internal Medicine, Division of Immunology, Manisa, Turkey. ckirmaz@mynet.com
Cengiz
C
Kirmaz
Ender
E
Terzioglu
Omer
O
Topalak
Papatya
P
Bayrak
Ozge
O
Yilmaz
Galip
G
Ersoz
Filiz
F
Sebik
D000328:Adult; D002908:Chronic Disease; D005260:Female; D016174:Hepacivirus / Q000276:immunology; D006509:Hepatitis B / Q000097:blood* / Q000276:immunology / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000276:immunology; D006526:Hepatitis C / Q000097:blood* / Q000276:immunology / Q000473:pathology / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D008103:Liver Cirrhosis / Q000097:blood* / Q000276:immunology / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D018417:Th1 Cells / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000097:blood* / Q000276:immunology
D016212:Transforming Growth Factor beta