Estimating the location and time course of synaptic input from multi-site potential recordings.
A method is introduced that permits accurate and robust extraction of the location and time course of synaptic conductance from potentials recorded on either side of, and perhaps at some distance from, the synapse in question. It is shown that such data permits one to fully overcome the problems typically associated with lack of spaceclamp. The method does not presume anything about the nature of the time course and yet is applicable to branched, active cells receiving simultaneous input from a number of synapses.
Cox
Steven J
SJ
Department of Computational and Applied Mathematics, Rice University, 6100 Main St., Houston, TX 77005, USA. cox@rice.edu
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003712:Dendrites / Q000502:physiology; D004553:Electric Conductivity; D007473:Ion Channels / Q000502:physiology; D008959:Models, Neurological; D009431:Neural Conduction / Q000502:physiology; D017711:Nonlinear Dynamics; D018408:Patch-Clamp Techniques / Q000379:methods; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D013997:Time Factors
D007473:Ion Channels