Hypospadias.
Hypospadias results from abnormal development of the penis that leaves the urethral meatus proximal to its normal glanular position anywhere along the penile shaft,scrotum, or perineum. Hypospadiology is an evolving and expanding discipline that remains at the forefront of pediatric surgical innovation. Although modern experiments have begun to yield a deeper understanding of the genetic, hormonal, and environmental basis of hypospadias, the quest for a surgical procedure that consistently results in a straight penis with a normally placed glanular meatus has challenged surgeons for over two centuries. This article focuses on the advances in the understanding of the etiology of hypospadias and the current approaches to the correction of hypospadias.
Division of Urology, The Children's Hospital of Philadelphia, 3rd Floor, Wood Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104-4399, USA.
Aseem R
AR
Shukla
Rakesh P
RP
Patel
Douglas A
DA
Canning
D017577:Cutaneous Fistula / Q000209:etiology; D006801:Humans; D007021:Hypospadias / Q000601:surgery*; D008297:Male; D010413:Penis / Q000601:surgery; D014521:Urethra / Q000601:surgery; D014522:Urethral Diseases / Q000209:etiology; D014548:Urinary Fistula / Q000209:etiology; D013521:Urologic Surgical Procedures, Male / Q000009:adverse effects / Q000379:methods