Acute generalized exanthematous pustulosis caused by celecoxib.
Acute generalized exanthematous pustulosis (AGEP) is a rapidly evolving, febrile, widespread, non-follicular pustular eruption mainly provoked by drugs. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor containing a sulfonamide substitute, is now clinically widely used due to its advantage of lower rate of gastrointestinal irritation. We report a case of AGEP in a 61-year-old woman who presented with fever, widespread maculopapules, vesicles, bullae, tiny pustules and leukocytosis soon after the ingestion of celecoxib. The condition resolved rapidly within 10 days. AGEP was diagnosed based on clinical and histopathological findings. Skin patch testing showed positive reaction to 1% celecoxib without cross-reactivity to 1% sulfamethoxazole-trimethoprim.
Department of Dermatology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chao-Chun
CC
Yang
Julia Yu-Yun
JY
Lee
Wen-Chieh
WC
Chen
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000068579:Celecoxib; D003875:Drug Eruptions / Q000209:etiology*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011720:Pyrazoles; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D013449:Sulfonamides / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib