Cyclosporine A-induced ocular opsoclonus and reversible leukoencephalopathy after orthotopic liver transplantation: brief report.
Ocular opsoclonus is a rare neurologic condition that occurs in patients with brain stem encephalitis, neoplasm of the mesencephalon, paraneoplastic syndrome or intoxication. Neurotoxicity is a well-known complication of cyclosporine-A (CSA) therapy. We report a case of a 17-year-old patient, a Caucasian female, who underwent an orthotopic liver transplantation (OLT) for immunologic cirrhosis and chronic cellular rejection respectively. The ocular symptoms occurred 8 days after the OLT. She also developed reversible posterior leukoencephalopathy. The serum level of CSA was 412 ng/mL. The ocular symptoms improved 21 days after the reduction of the CSA level.
Marchiori
Paulo Eurípedes
PE
Neurologic Clinic, Department of Neurology, São Paulo University School of Medicine, São Paulo, Brazil. div.neuro@hcnet.usp.br
Mies
Sergio
S
Scaff
Milberto
M
D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced*; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000601:surgery*; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods; D015835:Ocular Motility Disorders / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D016572:Cyclosporine