HLA class I and class II genotyping in patients with Behcet's disease: a regional study of eastern part of Turkey.
Class I human leucocyte antigen (HLA)-B51 is well known to be associated with Behcet's disease in many ethnic groups. However, there has been no published paper with respect to its association with HLA class I and class II among the Turkish people who live in the eastern region of Turkey. Moreover, as it is known that B51 antigen is encoded by 21 alleles, B*5101-5121, HLA-B51 allele typing was performed, as well as HLA class I and class II genotyping of 75 patients with the disease and the 54 individuals in the matched control group. The result shows that the HLA-B51 frequency was significantly higher (58.66%) in the patient group, compared to that in the control group (18.51%) (OR = 6.245). In the subtyping of B51 alleles, 44 B51-positive patients possessed B*5101 (45.5%), B*5108 (25%), B*5105 (9.1%) and B*5104 (4.5%). There was no significant difference in the HLA-B51 allelic distribution between the patient group and the control group. However, homozygous carriers of HLA-B51 showed considerably high risk (OR = 2.647) in the patient group, compared to that in the control group. In the genotyping of class II HLA alleles, while HLA-DRB1*04 (45.3%) and HLA-DRB1*07 (24%) were the predominant alleles in the patient group, DRB1*11 (50%) appeared to be more common in the control group.
Ataturk University, Medical School, Department of Medical Biology, 25240-Erzurum, Turkey. ipirim@hotmail.com
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I
Pirim
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Atasoy
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M
Ikbal
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Erdem
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Aliagaoglu
D001528:Behcet Syndrome / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II