Long-term control of hypercalcaemia in an infant with williams-Beuren syndrome after a single infusion of biphosphonate (Pamidronate).
OBJECTIVE
To report the efficacy of Pamidronate to treat hypercalcaemia in a patient with Williams-Beuren syndrome (WBS).


RESULTS
We report a 14-mo-old male infant presenting hypercalcaemia, elfin face and other dysmorphological features of WBS, confirmed by the FISH fluorescent test. Due to the marked symptomatic hypercalcaemia, 13.0 mg/dl intravenous Pamidronate was administered in a single dose of 1 mg/kg. Two days later, serum calcium diminished to normal levels, and remained within normal range during 12 mo follow-up.


CONCLUSIONS
Pamidronate appears to be effective in paediatric patients with WBS and hypercalcaemia.
Sección Osteopatías Médicas, Hospital de Clínicas, Argentina. osteologia@ciudad.com.ar
B
B
Oliveri
S R
SR
Mastaglia
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C
Mautalen
J C
JC
Gravano
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L
Pardo Argerich
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D004164:Diphosphonates / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000188:drug therapy*; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D000077268:Pamidronate; D013997:Time Factors; D018980:Williams Syndrome / Q000150:complications*
D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000077268:Pamidronate; D002118:Calcium