The anemia of chronic renal failure revisited.
The mechanisms of the anemia of chronic renal failure are reviewed. Ineffective erythropoiesis is undoubtedly the major cause of this anemia. The contributions of inadequate erythropoietin secretion by the diseased kidneys, suppressive effects of uremic "toxins" on erythropoiesis and red cell survival, excess blood loss, and plasma concentrations of parathyroid hormone, calcium and phosphate are discussed.
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37914.
J R
JR
Easley