New cytotoxic alkyl phloroglucinols from Protorhus thouvenotii.
Two new cytotoxic alkylene phloroglucinols and one known compound were isolated through chromatographic separation from the methanolic extract of the dried fruits of Protorhus thouvenotii (Anacardiaceae). The compounds showed marginal in vitro cytotoxicity in the A2780 ovarian cancer cell line assay with an IC50 of 11 microg/mL.
Department of Chemistry M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Shugeng
S
Cao
Jennifer K
JK
Schilling
Armand
A
Randrianasolo
Rabodo
R
Andriantsiferana
Vincent E
VE
Rasamison
David G I
DG
Kingston
D027926:Anacardiaceae; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D005638:Fruit; D006801:Humans; D020128:Inhibitory Concentration 50; D010696:Phloroglucinol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D010696:Phloroglucinol