Activities of synthetic peptides against human pathogenic bacteria.
The increasing problem of antibiotic resistance among pathogenic bacteria requires development of new antimicrobial agents. Synthesis and experimental application of the hybrids peptides may be one of the interesting possibilities in antimicrobial treatment. The aim of the present investigation is to determinate in vitro activities of two synthetic peptide amides: cecropin-melittin hybrid peptide (CAMEL) and protegrin analogue (IB-367) against control strains and multi-resistant clinical isolates. Antimicrobial activities were measured by MIC and MBC. The tested strains were susceptible to the peptides at concentrations in the range of 1 to 32 microg ml(-1).
Department of Bacteriology, Provincial Hospital of Gdańsk, Poland.
Krystyna
K
Bogucka
Aleksandra
A
Królicka
Wojciech
W
Kamysz
Tadeusz
T
Ossowski
Jerzy
J
Lukasiak
Ewa
E
Lojkowska
D000595:Amino Acid Sequence; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008555:Melitten / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010455:Peptides; D011506:Proteins / Q000494:pharmacology*
D023181:Antimicrobial Cationic Peptides; D010455:Peptides; D011506:Proteins; D008555:Melitten; C031161:cecropin A; C119872:antimicrobial peptide IB-367