Chiral benzyl centers through asymmetric catalysis. a three-step synthesis of (R)-(-)-alpha-curcumene via asymmetric hydrovinylation.
[reaction: see text] A three-step, two-pot procedure involving asymmetric hydrovinylation followed by Suzuki-Miyaura reaction represents by far the shortest synthesis of this popular bisabolane. Other applications for the synthesis of similar compounds with chiral benzyl centers can be easily envisioned.
Zhang
Aibin
A
Department of Chemistry, 100 West 18th Avenue, The Ohio State University, Columbus, Ohio 43210, USA.
RajanBabu
T V
TV
D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003474:Curcumin / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis; D007202:Indicators and Reagents; D015394:Molecular Structure; D012717:Sesquiterpenes; D013237:Stereoisomerism
D001555:Benzene Derivatives; D007202:Indicators and Reagents; D012717:Sesquiterpenes; C086829:alpha-curcumene; D003474:Curcumin