Controlled photochemical release of nitric oxide from O2-substituted diazeniumdiolates.
Diazeniumdiolates are a well-established class of nitric oxide (NO) donors that have been employed in a wide variety of biochemical and pharmacological investigations. To provide a means of targeting NO release, photosensitive precursors to diazeniumdiolates have been developed and are reviewed here. After a brief description of diazeniumdiolate chemistry and the potential uses of photosensitive precursors to NO, three different classes of phototriggered diazeniumdiolates are discussed: 2-nitrobenzyl derivatives, meta-substituted benzyl derivatives, and naphthylmethyl and naphthylallyl derivatives. In addition, the photochemistry of diazeniumdiolate salts themselves is covered.
Pavlos
Christopher M
CM
Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Xu
Hua
H
Toscano
John P
JP
D000818:Animals; D001391:Azo Compounds / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism*; D009578:Nitrobenzenes / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry*; D010777:Photochemistry / Q000379:methods; D017319:Photosensitizing Agents / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry
D001391:Azo Compounds; D009578:Nitrobenzenes; D017319:Photosensitizing Agents; D011355:Prodrugs; C452539:diazeniumdiolate; D009569:Nitric Oxide; D010100:Oxygen