Peptide damage under Fenton conditions is sequence-dependent.
Peptides with two or more acidic amino acids are damaged to a greater extent than other peptides under Fenton conditions as revealed by treating a 29791 membered one-bead-one-compound peptide library with FeCl(3), sodium ascorbate and hydrogen peroxide.
Nold
Matthias
M
Department of Chemistry, University of Basel, St. Johanns Ring 19, 4056 Basel, Switzerland.
Wennemers
Helma
H
D000595:Amino Acid Sequence; D024342:Amino Acids, Acidic / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry; D002712:Chlorides; D005290:Ferric Compounds / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry*; D019151:Peptide Library; D013050:Spectrometry, Fluorescence
D024342:Amino Acids, Acidic; D002712:Chlorides; D005290:Ferric Compounds; D010446:Peptide Fragments; D019151:Peptide Library; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid; C024555:ferric chloride