A low-dose radioisotope procedure for assessment of subcutaneous drug delivery systems used for slow intrathecal infusion of antispasmodic agents.
METHODS
Retrospective single centre study.


OBJECTIVE
To evaluate a low-dose radioisotope imaging procedure for assessment of implanted intrathecal drug delivery and to compare the radiation dose and diagnostic value of these studies with other reported studies using higher administered radiation dose.


METHODS
National Spinal Injuries Centre, Stoke Mandeville Hospital, UK.


METHODS
A total of 11 spinally injured patients with subcutaneous drug delivery systems and uncontrolled spasm were investigated for catheter failure using a low-dose radioisotope procedure with an administered dose of radioactivity of 40 MBq Technetium-99m.


RESULTS
Loss of catheter patency was demonstrated in six patients, enabling identification of the site of blockage. Catheter patency and subsequent perfusion of CSF (ie normal result) was demonstrated in five patients. Radiation effective dose was estimated at 1.3 mSv per patient study, with a low associated risk of deleterious effect of one in 13,000.


CONCLUSIONS
Radioisotope investigation using a reduced administered dose of 40 MBq Technetium-99m DTPA, formulated according to a strict radiopharmaceutical protocol, provides a safe test for assessment of intrathecal drug delivery systems.
Crawley
M T
MT
Radiology Department, Stoke Mandeville Hospital, Mandeville Road, Aylesbury, Buckinghamshire, UK.
Murphy
P
P
Jamous
A
A
Bodley
R
R
D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007278:Injections, Spinal; D007279:Injections, Subcutaneous; D010276:Parasympatholytics / Q000008:administration & dosage*; D011868:Radioisotopes / Q000008:administration & dosage; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000000981:diagnostic imaging*; D013667:Technetium / Q000008:administration & dosage*
D010276:Parasympatholytics; D011868:Radioisotopes; D013667:Technetium