T594M mutation of the epithelial sodium channel beta-subunit gene in pre-eclampsia and eclampsia in Black South African women.
The possible role of the beta-subunit of the epithelial sodium channel T594M polymorphism in hypertensive disorders of pregnancy has not been examined. This study compared Black South African women with pre-eclampsia (n= 204), early onset pre-eclampsia (n= 67), eclampsia (n= 120) and gestational hypertension (n= 78) with 338 women from the same ethnic group who had full-term normotensive pregnancies, for the presence of the T594M polymorphism. The variant allele was detected in 1.7% to 3.8% of the various patient groups and in 3.6% of the control group reflecting no significant difference. These results suggest that the T594M polymorphism in the sodium channel beta-subunit is not associated with the pathogenesis of pre-eclampsia or gestational hypertension.
Department of Chemical Pathology, Nelson R. Mandela School of Medicine, University of Natal, Congella 4013, Durban, South Africa.
R J
RJ
Pegoraro
C B
CB
Roberts
L
L
Rom
J
J
Moodley
D044383:Black People / Q000235:genetics*; D004461:Eclampsia / Q000235:genetics*; D005260:Female; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic / Q000235:genetics; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy; D021122:Protein Subunits / Q000235:genetics*; D015222:Sodium Channels / Q000235:genetics*; D013019:South Africa; D062548:Voltage-Gated Sodium Channel beta-2 Subunit
D009419:Nerve Tissue Proteins; D021122:Protein Subunits; C117620:SCN2B protein, human; D015222:Sodium Channels; D062548:Voltage-Gated Sodium Channel beta-2 Subunit