Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.
Karran
P
P
Department of Medical Chemistry, University of Gothenburg, Sweden.
Lindahl
T
T
Griffin
B
B
D000222:Adaptation, Physiological / Q000187:drug effects*; D000478:Alkylation / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D004269:DNA, Bacterial / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism*; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation / Q000235:genetics; D019853:O(6)-Methylguanine-DNA Methyltransferase; D014157:Transcription Factors
D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D009153:Mutagens; D014157:Transcription Factors; D008769:Methylnitronitrosoguanidine; D006147:Guanine; C008449:O-(6)-methylguanine; C045675:Ada protein, E coli; D019853:O(6)-Methylguanine-DNA Methyltransferase