Reversal of dialysis-dependent renal failure in light-chain deposition disease by autologous peripheral blood stem cell transplantation.
Specific treatment of light-chain deposition disease has been reported as ineffective in altering the course of the severe or end-stage renal failure it causes. The authors describe a case of biopsy-proven primary light-chain deposition disease of the kidney, severe renal failure, and incipient dialysis dependency, treated by autologous peripheral blood stem cell transplantation, that led to reversal of dialysis dependency and sustained improvement in renal function.
Firkin
Frank
F
Department of Clinical Hematology, University of Melbourne, Melbourne, Australia.
Hill
Prudence A
PA
Dwyer
Karen
K
Gock
Hilton
H
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D006801:Humans; D007147:Immunoglobulin Light Chains; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000628:therapy*; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications*; D036102:Peripheral Blood Stem Cell Transplantation; D012074:Remission Induction; D006435:Renal Dialysis; D014182:Transplantation, Autologous
D018906:Antineoplastic Agents, Alkylating; D007147:Immunoglobulin Light Chains; D008558:Melphalan