Biphosphonate-induced radiographic changes in two pediatric patients with rheumatic diseases.
Biphosphonates are now being used experimentally in children to increase bone mass, but their long-term effects remain an issue of concern. We report two cases of biphosphonate-induced radiographic changes in children with rheumatic diseases. Our experience supports the view that clinical improvement and radiographic findings after biphosphonate therapy are related to increased bone mineral density, without effects on the inflammatory process itself. Biphosphonates seem to act in rheumatic diseases by reducing bone turnover instead of improving disease activity.
Magnetic Resonance Department, Hospital Santa Lucia, Brasilia DF, Brazil.
Joao L
JL
Fernandes
Sergio L
SL
Viana
Arthemizio L
AL
Rocha
Maria C
MC
Ribeiro
Luis C
LC
Castro
D019386:Alendronate / Q000494:pharmacology / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000000981:diagnostic imaging / Q000188:drug therapy*; D015519:Bone Density / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects; D002648:Child; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011859:Radiography; D016896:Treatment Outcome
D004164:Diphosphonates; D019386:Alendronate