First total synthesis of the antitumor compound (-)-kazusamycin A and absolute structure determination.
The first total synthesis of kazusamycin A, a potent antitumor compound from an actinomycete, has been achieved, and its absolute structure was determined. Paterson's stereoselective aldol reaction was successfully applied to construct the contiguous chiral centers by using an originally designed optically active 2-acyl-1,3-propanediol derivative.
Creation and Function of New Molecules and Molecular Assemblies, Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.
Noriyoshi
N
Arai
Noriko
N
Chikaraishi
Satoshi
S
Omura
Isao
I
Kuwajima
D039903:Actinobacteria / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D002384:Catalysis; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; C042541:kazusamycin A