Self-supported heterogeneous catalysts for enantioselective hydrogenation.
"Self-supported" catalysts were prepared by the reaction of bis-MonoPhos ligand with rhodium(I) metallic ion on the basis of molecular assembling through coordination. These polymeric metal-organic assemblies are insoluble in common organic solvents and, as a result, provide an excellent opportunity for running asymmetric catalysis heterogeneously. The application of the self-supported Rh(II) catalysts in the asymmetric hydrogenation of olefin derivatives afforded a variety of enantioenriched amino acid and amine derivatives with high yields and enantioselectivities. This strategy might provide a new direction in asymmetric catalysis, particularly for the development of practical heterogeneous asymmetric synthesis of optically active compounds.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China.
Xingwang
X
Wang
Kuiling
K
Ding