Evaluation of additional amine fluoride/stannous fluoride-containing mouthrinse during supportive therapy in patients with generalized aggressive periodontitis. A randomized, crossover, double-blind, controlled trial.
OBJECTIVE
The objective of the present randomized controlled trial was to evaluate the efficacy of a mouthrinse containing a combination of AmF/SnF2 in controlling supragingival plaque accumulation and gingival inflammation during a 12-week period in patients affected by generalized aggressive periodontitis (GAP).


METHODS
Eighteen subjects, six males and 12 females, mean age: 32.2 years, were evaluated. One-half of the patients was either prescribed an AmF/SnF2-containing mouthrinse (test mouthrinse) or a control mouthrinse in addition to mechanical plaque control for 12 weeks. After a 2-week wash-out period, the patients received the alternative mouthrinse. Before and after treatment plaque index (PlI), gingival index (GI), angulated bleeding index (AngBI), tooth stain (GMSI), and tongue stain were recorded.


RESULTS
Test mouthrinse resulted in a statistically significant decrease in PlI (p = 0.029) and GI (p = 0.017). After treatment, PlI was significantly lower in test compared to control mouthrinse (p = 0.027). GMSI significantly increased post-treatment for both mouthrinse regimens (p < 0.001), a significantly higher score being observed for the test compared to control mouthrinse (p = 0.002).


CONCLUSIONS
The 12-week use of a AmF/SnF2-containing mouthrinse as an adjunct to conventional mechanical oral hygiene procedures in GAP patients was effective in controlling the amount of supragingival plaque deposits.
Guarnelli
Maria Elena
ME
Research Center for the Study of Periodontal Diseases, University of Ferrara, Ferrara, Italy.
Zangari
Francesca
F
Manfrini
Roberta
R
Scapoli
Chiara
C
Trombelli
Leonardo
L
D000328:Adult; D000704:Analysis of Variance; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005460:Fluorides, Topical / Q000009:adverse effects / Q000627:therapeutic use*; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D010512:Periodontal Index; D010518:Periodontitis / Q000628:therapy*; D018709:Statistics, Nonparametric; D014002:Tin Fluorides / Q000009:adverse effects / Q000627:therapeutic use*; D014075:Tooth Discoloration / Q000139:chemically induced
D004338:Drug Combinations; D005460:Fluorides, Topical; D009067:Mouthwashes; D014002:Tin Fluorides; C094808:amine fluoride solution