Molecular characterization of the porcine TYK2 gene on SSC 2q1.3-->q2.1.
TYK2 is a member of the janus protein kinase family and plays an important role in the signal transduction of various cytokines including interferon alpha/beta. Cloning and characterization of the porcine TYK2 gene revealed a conserved organization with respect to other mammalian TYK2 orthologs. The porcine gene consists of 25 exons spanning approximately 26 kb and encoding a 5.3-kb mRNA. It is located in a GC-rich and gene-rich chromosome region and contains several CpG islands. The predicted 132-kDa TYK2 protein consists of 1,184 amino acids and shows 85% identity to the human TYK2 protein. The porcine TYK2 gene was localized by FISH and RH-mapping on SSC 2q1.3-->q2.1, which is in good agreement with established human-mouse-pig comparative maps.
Leeb
T
T
Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Hannover, Germany. Tosso.Leeb@tiho-hannover.de
Martins-Wess
F
F
Kuiper
H
H
Lassnig
C
C
Distl
O
O
Müller
M
M
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods; D033481:Chromosomes, Mammalian / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons / Q000235:genetics; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods; D013552:Swine / Q000235:genetics*
D018076:DNA, Complementary; D011505:Protein-Tyrosine Kinases