[Stress and drug dependence (animal studies)].
This review describes a role of stress in formation of the primary drug-taking behaviour and the effects of stress on a drug-seeking behaviour after withdrawal of drugs. The psychophysiological and neurochemical mechanisms of the rewarding and aversive states during a drug taking and after its withdrawal are considered. A role of separate neurotransmitters and their interactions in formation of drug dependence and the effects of stress on neuroadaptive changes in these neurotransmitter systems are described. A review of the structures involved in mediation of the stress effects and a drug-seeking behaviour is also discussed.
G A
GA
Grigor'ian
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000679:Amygdala / Q000187:drug effects; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000187:drug effects; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D000882:Haplorhini; D009294:Narcotics / Q000008:administration & dosage / Q000009:adverse effects*; D009638:Norepinephrine / Q000378:metabolism; D009714:Nucleus Accumbens / Q000187:drug effects; D051381:Rats; D012646:Self Administration; D013315:Stress, Psychological / Q000150:complications*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D019966:Substance-Related Disorders / Q000150:complications*
D009294:Narcotics; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D004298:Dopamine; D009638:Norepinephrine