Effect of a single dose of sodium bicarbonate given during neonatal resuscitation at birth on the acid-base status on first day of life.
OBJECTIVE
To study the effect of a single dose of sodium bicarbonate given during neonatal resuscitation at birth on the acid-base status on the first day of life.


METHODS
Tertiary care Level III NICU.


METHODS
A total of 55 consecutively born asphyxiated neonates continuing to receive positive pressure ventilation at 5 minutes of life were randomized to receive either 4 ml/kg (1.8 meq/kg) of sodium bicarbonate or 5% dextrose.


RESULTS
The mean pH, base deficit and PaCO(2) were similar between the Base group and the Control group for the first 24 hours of life. The number of babies with persistent metabolic acidosis at 1, 6, 12 and 24 hours were comparable between the two groups.


CONCLUSIONS
Sodium bicarbonate given during neonatal resuscitation did not change the acid-base status in the first 24 hours of life.
Neonatal Unit, Department of Pediatrics, Advanced Pediatrics Center, PGIMER, Chandigarh, India.
Srinivas
S
Murki
Praveen
P
Kumar
Lokesh
L
Lingappa
Anil
A
Narang
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D001238:Asphyxia Neonatorum / Q000628:therapy*; D002245:Carbon Dioxide / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008991:Monitoring, Physiologic; D010313:Partial Pressure; D012151:Resuscitation / Q000379:methods*; D017693:Sodium Bicarbonate / Q000008:administration & dosage*
D002245:Carbon Dioxide; D017693:Sodium Bicarbonate