2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.
2-(Anilino)imidazolines were identified as novel human 5-HT(1D) receptor ligands, but offered no particular advantage over previously reported 2-(benzyl)imidazolines. Pharmacokinetic and functional data were obtained for selected 2-(benzyl)imidazoline derivatives.
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
Thomas
T
Prisinzano
Małgorzata
M
Dukat
Ho
H
Law
Abdelmalik
A
Slassi
Neil
N
MacLean
Inés
I
DeLannoy
Richard A
RA
Glennon
D000262:Adenylyl Cyclases / Q000378:metabolism; D000814:Aniline Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001593:Benzyl Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D048288:Imidazolines / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008024:Ligands; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D011869:Radioligand Assay; D051381:Rats; D044346:Receptor, Serotonin, 5-HT1D / Q000378:metabolism*; D012501:Saphenous Vein / Q000187:drug effects / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D001593:Benzyl Compounds; D048288:Imidazolines; D008024:Ligands; D044346:Receptor, Serotonin, 5-HT1D; D017366:Serotonin Receptor Agonists; D000262:Adenylyl Cyclases