Antimicrobial susceptibility and macrolide resistance genes in Streptococcus pyogenes collected in Austria and Hungary.
A total of 341 clinical isolates of Streptococcus pyogenes from Vienna, Austria and three Hungarian cities were tested for susceptibility to four macrolides and 12 other antibiotics. All isolates were fully susceptible to penicillin and the other beta-lactams tested. A high level of tetracycline resistance was found in Austria (26.7%) and in Hungary (30.5%). The rate of resistance to erythromycin, clarithromycin and azithromycin was 4.7% in Vienna and 3.7% in the Hungarian communities. In both countries, the MIC(90) values of erythromycin and clarithromycin were 0.12 mg/L and the MIC(90) of josamycin was 0.5mg/L. The M phenotype of resistance conferred by the mefA genes was predominant (n = 9) among the macrolide-resistant isolates (n = 14).
Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy, Vienna General Hospital, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Rainer
R
Gattringer
Robert
R
Sauermann
Heimo
H
Lagler
Karin
K
Stich
Astrid
A
Buxbaum
Wolfgang
W
Graninger
Apostolos
A
Georgopoulos
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001317:Austria; D017963:Azithromycin / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D017291:Clarithromycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D006814:Hungary; D015570:Josamycin / Q000494:pharmacology; D018942:Macrolides / Q000494:pharmacology*; D008565:Membrane Proteins / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010612:Pharyngitis / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D012867:Skin / Q000382:microbiology; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013753:Tetracycline Resistance; D014069:Tonsillitis / Q000382:microbiology; D014621:Vagina / Q000382:microbiology; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018942:Macrolides; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D047090:beta-Lactams; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin; D015570:Josamycin