Hitting the target with bifunctional phage.
Peptide libraries are rich sources of cell-targeting peptides. In this issue of Chemistry & Biology, Pasqualini and coworkers have developed a chimeric cell-targeting phage system that can easily be modified to delivery of a variety of reagents without need for chemical conjugation.
Brown
Kathlynn C
KC
Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
D000818:Animals; D001435:Bacteriophages / Q000235:genetics*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008024:Ligands; D019151:Peptide Library; D015202:Protein Engineering; D011993:Recombinant Fusion Proteins / Q000235:genetics* / Q000378:metabolism*
D008024:Ligands; D019151:Peptide Library; D011993:Recombinant Fusion Proteins