Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS.
There are significant associations between possession of certain HLA class I alleles and rate of progression to AIDS. Immunological data provide an explanatory mechanism for this relationship. Patients with HLA types associated with rapid disease progression recognize a significantly smaller fraction of their known repertoire of viral epitopes than do patients with HLA types associated with slow progression. Population frequency of HLA types (or supertypes) and their capacity to elicit cytotoxic T lymphocyte responses are also negatively correlated. These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV.
Zoology Department, Oxford University, South Parks Road, Oxford OX1 3PS, United Kingdom.
Almut
A
Scherer
John
J
Frater
Annette
A
Oxenius
Juliet
J
Agudelo
David A
DA
Price
Huldrych F
HF
Günthard
Martin
M
Barnardo
Luc
L
Perrin
Bernard
B
Hirschel
Rodney E
RE
Phillips
Angela R
AR
McLean
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000235:genetics / Q000276:immunology*; D000328:Adult; D000368:Aged; D000483:Alleles; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018448:Models, Immunological; D013030:Spain; D013557:Switzerland; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006680:HLA Antigens