Grafting copolymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) onto pre-irradiated cellulose films.
Grafting of 2-methacryloyloxyethyl phosphorylcholine (MPC) and poly(ethylene glycol mathacrylate) (PEGMA) onto cellulose films was performed using the pre-irradiation grafting method. The effects of monomer concentration, solvent system and co-solvent composition, and reaction time on the degree of grafting were determined. The grafted samples were confirmed by FT-IR-ATR spectra. The blood compatibilities of the grafted cellulose were evaluated by platelet-rich plasma contact studies and viewed by scanning electron microscopy; non-grafted cellulose film sample was used as references. As a result, MPC and MPC/PEGMA were grafted on the surface of cellulose films. It was found that fewer platelets adhered to the MPC-grafted surfaces and that they showed less shape variation than the ungrafted references.
Chen
Jie
J
Department of Chemical Engineering and Technology, Shanghai University (Jiadiang Campus), Jiading, Shanghai, China. chenjjd@online.sh.cn
Nho
Young Chang
YC
Hoffman
Allan S
AS
D001672:Biocompatible Materials; D001792:Blood Platelets / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D006648:Histocompatibility; D006801:Humans; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry*; D010949:Plasma / Q000737:chemistry*; D010973:Platelet Adhesiveness; D011108:Polymers / Q000737:chemistry; D011827:Radiation; D012997:Solvents; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D008689:Methacrylates; D011108:Polymers; D012997:Solvents; D014867:Water; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine; D002482:Cellulose