Sibutramine use in pregnancy: report of two cases.
BACKGROUND
Sibutramine is a drug used for the medical treatment of obesity. No data are available on sibutramine use in pregnancy. We report the fetal outcomes of two pregnant women exposed to sibutramine.


METHODS
The first woman was exposed to 10 mg/day of sibutramine during gestational weeks 4-6. The second woman was exposed to 10 mg/day of sibutramine during gestational weeks 5-8. At weeks 37 and 39, they delivered healthy infants.


CONCLUSIONS
To our knowledge, this is the first report of sibutramine exposure in pregnancy. These cases may contribute to the knowledge about sibutramine use during pregnancy.
Department of Pharmacology, School of Medicine, Karadeniz Technical University, TR-61187 Trabzon, Turkey. mkadioglu@meds.ktu.edu.tr
Mine
M
Kadioglu
Cunay
C
Ulku
Fusun
F
Yaris
Murat
M
Kesim
Nuri Ihsan
NI
Kalyoncu
Ersin
E
Yaris
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003503:Cyclobutanes / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000523:psychology*; D012016:Reference Values
D000928:Antidepressive Agents; D003503:Cyclobutanes; C058254:sibutramine