Impact of retained embryos on the outcome of assisted reproductive technologies.
OBJECTIVE
To assess the impact of embryo retention in the embryo transfer catheter followed by "immediate" retransfer on pregnancy outcome in women undergoing assisted reproduction.


METHODS
Retrospective analysis of embryo transfer following in vitro fertilization.


METHODS
Assisted reproductive technology practice in a university in vitro fertilization program.


METHODS
In vitro fertilization charts for 1,812 embryo transfer cycles representing 1,139 patients between January 1997 and March 2002 were reviewed.


METHODS
None.


METHODS
Pregnancy rate, implantation rate, delivery rate.


RESULTS
Three embryo transfer cycles were excluded from analysis because of missing data, leaving 1,364 embryo transfers during oocyte recovery cycles and 445 embryo transfer cycles using thawed embryos. Seventy-one embryo transfers (3.9% of all transfers) were complicated by finding retained embryos after the initial embryo transfer-all retained embryos were immediately retransferred. There was no difference in the frequency of retained embryos during oocyte retrieval versus thawed embryo cycles. The pregnancy, implantation, and delivery rates per embryo transfer were not negatively affected by embryo(s) retained in the transfer catheter. Age, fresh versus frozen embryo, use of ultrasound during the procedure, or transferring physician did not influence pregnancy outcome.


CONCLUSIONS
Immediate retransfer of embryos retained in the catheter following the initial transfer attempt did not have an adverse effect on pregnancy outcome.
Lee
Hye-Chun
HC
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, UMDNJ-Robert Wood Johnson Medical School, 303 George Street, New Brunswick, NJ 08901, USA.
Seifer
David B
DB
Shelden
Robert M
RM
D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D036861:Delivery, Obstetric; D004624:Embryo Transfer / Q000706:statistics & numerical data*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D013997:Time Factors
D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human