Design of an inversion center between two helical segments.
A new strategy is proposed to control the relative orientation of two folded helical oligomers in such a way that they diverge from an aromatic linker and have opposite helical handedness. Mutual steric exclusion between the two helices results from the fact that they cannot be at the same time folded and on the same side of the linker. The concept is validated using the helical conformations of oligoamides of 8-amino-2-quinolinecarboxylic acid, but it should be applicable to many families of oligomers and leads to the first designed meso-helices.
Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France.
Victor
V
Maurizot
Christel
C
Dolain
Yoann
Y
Leydet
Jean-Michel
JM
Léger
Philippe
P
Guionneau
Ivan
I
Huc
D040761:Biomimetic Materials / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009757:Nylons / Q000737:chemistry*; D017433:Protein Structure, Secondary; D011804:Quinolines / Q000737:chemistry*; D012996:Solutions
D002264:Carboxylic Acids; D009757:Nylons; D011804:Quinolines; D012996:Solutions