Intralesional bleomycin injections for the palliation of epistaxis in hereditary hemorrhagic telangiectasia.
Epistaxis is a common complication in patients with hereditary hemorrhagic telangiectasia. Its treatment is generally aimed at controlling the frequency and severity of nasal hemorrhage and involves surgery, transcatheter embolization, topical treatment, or a combination. Despite this multitude of treatment methods, the long-term prognosis for many patients remains poor. We describe a patient in whom direct intralesional injections of bleomycin successfully palliated severe recurrent epistaxis for almost 2 years without the need for adjuvant therapy.
Duncan
Ian C
IC
Unitas Interventional Unit, Centurion, South Africa.
Van Der Nest
Leon
L
D000768:Anesthesia, General; D015901:Angiography, Digital Subtraction; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004844:Epistaxis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000098:blood supply; D019233:Retreatment; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000000981:diagnostic imaging / Q000188:drug therapy*
D000964:Antimetabolites, Antineoplastic; D001761:Bleomycin