FISH--a new noninvasive method for the diagnosis of urinary bladder carcinomas.
Urinary bladder carcinoma is one of the most frequent malignant tumour diseases. The frequency increases with advancing age. The knowledge increase about genetic changes in tumour cells opens the possibility of a new noninvasive diagnosis with the help of fluorescence in situ hybridization (FISH). Comparable data are obtained by application of different diagnostic methods (fluorescence in situ hybridization, urinary bladder cancer ELISA, urinary cytology, histopathology) at different times from 6 coincidentally selected patients (preoperation, biopsy material and postoperation). The FISH test proved to be a sensitive method and correlated with the histopathological data.
Institute of Pathology, Carl-Thiem Clinic, Cottbus, Germany.
Lieselotte
L
Lübbe
Rudolf
R
Nowack
Matthias
M
May
Kerstin
K
Ullmann
Sven
S
Gunia
Olaf
O
Kaufmann
Oliver
O
Hakenberg
Joachim
J
Muche
Bernd
B
Hoschke
D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014556:Urine / Q000166:cytology