Aptamers meet allostery.
Engineered RNAs have demonstrated remarkable properties of molecular recognition and allosteric function. Liu and colleagues now report the isolation and in vivo function of a ligand-dependent RNA-based transcription factor that opens wide the door for allosterically controllable aptamers.
Soukup
Garrett A
GA
Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska, 68178, USA.
D000494:Allosteric Regulation; D000495:Allosteric Site; D005818:Genetic Engineering; D006575:Heterocyclic Compounds, 3-Ring / Q000378:metabolism; D008024:Ligands; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D012235:Rhodamines; D015533:Transcriptional Activation / Q000235:genetics*
D006575:Heterocyclic Compounds, 3-Ring; D008024:Ligands; D012235:Rhodamines; C412715:tetramethylrosamine; D012313:RNA