Polytriazoles as copper(I)-stabilizing ligands in catalysis.
Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.
Timothy R
TR
Chan
Robert
R
Hilgraf
K Barry
KB
Sharpless
Valery V
VV
Fokin
D000588:Amines / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
D000588:Amines; D008024:Ligands; D011108:Polymers; D014230:Triazoles; D003300:Copper