Nondiabetic ketoacidosis caused by severe hyperthyroidism.
Severe hyperthyroidism is not included in the traditional differential diagnosis of ketoacidosis. However, thyroid hormone has well-documented lipolytic effects on adipocytes and may also promote hepatic beta-oxidation. We present a case in which a woman with severe hyperthyroidism developed otherwise unexplained ketoacidosis during the acute phase of her illness. We propose that thyrotoxicosis was a significant contributor to ketoacidosis in this patient and that severe hyperthyroidism should be added to the differential diagnosis of ketoacidosis.
Wood
Emily T
ET
Department of Medicine, Division of Endocrinology and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, USA.
Kinlaw
William B
WB
D000138:Acidosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D016883:Diabetic Ketoacidosis / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D007659:Ketones / Q000097:blood*; D012720:Severity of Illness Index
D007659:Ketones