[The prevalence of patent foramen ovale in patients with migraine].
OBJECTIVE
Migraine is a common neurologic disorder whose etiology remains unknown. Migraine has been reported as a possible risk factor for ischemic stroke, especially in young women. The relationship between migraine and stroke is stronger in patients suffering from migraine with aura compared to those with common migraine. Coexistence of migraine and patent foramen ovale (PFO) should be also considered. The aim of our study was to evaluate the frequency of PFO in patients with migraine with aura (MA) and compare it with the prevalence of PFO in migraine patients without aura (M) and in a healthy age-matched control group.


METHODS
We assessed 62 patients (48 females) suffering from migraine with aura, 60 without aura (53 females) and 65 normal controls (51 females). In order to detect PFO the contrast transcranial Doppler was performed during Valsalva maneuver.


RESULTS
The presence of PFO was found in 33/62 (53%) patients with MA compared to 15/60 (25%) without aura, and in 16/65 (25%) control subjects. The difference in PFO prevalence between MA patients and M patients and the difference between MA patients and the control group was statistically significant (p<0.05).


CONCLUSIONS
Our findings suggest that at least some attacks of migraine with aura may be associated with paradoxical embolism.
Domitrz
Izabela
I
Klinika Neurologii, Akademia Medyczna w Warszawie. domitrz@amwaw.edu.pl
Mieszkowski
Jerzy
J
Kwieciński
Hubert
H
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000209:etiology*; D015995:Prevalence; D020521:Stroke / Q000209:etiology*; D017585:Ultrasonography, Doppler, Transcranial; D014636:Valsalva Maneuver