Natural medicaments in endodontics -- a comparative study of the anti-inflammatory action.
The objective of this study was to evaluate the irritant potential of propolis, Casearia sylvestris, Otosporin and saline solution (control). Twenty-eight male Wistar rats were selected, anesthetized and four experimental sites were designed on their backs. Injections of 2% Evans blue were intravenously administered in the lateral caudal vein and 0.1 ml of the tested solutions was injected intradermally into the experimental sites. The animals were killed 1/2, 1, 3 and 6 hours after the injection of the solutions. Each piece of skin containing the lesion was immersed in formamide and incubated at 45 masculine C for 72 h. After filtration, optical density was measured in a spectrophotometer. Data were statistically analyzed by a 2-way non-parametric test. The highest values of extracted dye were observed at 3 hours characterizing a peak in the inflammatory process. Propolis was the least irritant solution. The natural medicaments tested in this study may be a valuable alternative for endodontic treatment.
Center of Biological Sciences and Professions of Health, University of Sacred Heart, Bauru.
Fabiane Bortoluci da
FB
Silva
Juliano Milanezi de
JM
Almeida
Simone Maria Galvão de
SM
Sousa
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002199:Capillary Permeability; D037821:Casearia; D004396:Coloring Agents / Q000493:pharmacokinetics; D003786:Dental Pulp Cavity / Q000187:drug effects*; D004338:Drug Combinations; D005070:Evans Blue / Q000493:pharmacokinetics; D006854:Hydrocortisone / Q000493:pharmacokinetics; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D009355:Neomycin / Q000493:pharmacokinetics; D008517:Phytotherapy; D011112:Polymyxin B / Q000493:pharmacokinetics; D011429:Propolis / Q000009:adverse effects* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D004396:Coloring Agents; D004338:Drug Combinations; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D012965:Sodium Chloride; D005070:Evans Blue; D011429:Propolis; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone