Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2.
Allelic definition within the killer cell immunoglobulin-like receptor gene, KIR3DL2, has been achieved through a sequence-specific oligonucleotide probe methodology, designed around the specific amplification of the D0 and D1 domains and a section of the cytoplasmic tail of this gene. The system has been applied to a healthy Northern Irish control group, establishing frequencies for this Caucasian population. Additionally, the KIR3DL2 allele status of cell line DNA and Centre d'Etude du Polymorphisme Humain (CEPH) families, both from the 13th International Histocompatibility Workshop, has been established. A high level of KIR3DL2 allelic polymorphism has been identified.
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, UK.
A
A
Meenagh
F
F
Williams
C
C
Sleator
I A
IA
Halfpenny
D
D
Middleton
D014644:Genetic Variation; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000276:immunology*; D011971:Receptors, Immunologic / Q000235:genetics* / Q000276:immunology; D054340:Receptors, KIR; D054347:Receptors, KIR3DL2; D044465:White People / Q000235:genetics
C515084:KIR3DL2 protein, human; D015345:Oligonucleotide Probes; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054347:Receptors, KIR3DL2