Highly efficient dendrimer-based mimic of glutathione peroxidase.
In this communication, we report the synthesis of the three generations of Fréchet-type poly(aryl ether) dendrimers with a diselenide core that demonstrate generation-dependent glutathione peroxidase (GPx) activity with initial reduction rates as high as 2431.20 muM min-1 for the third-generation product, around 1400 times faster than Ebselen. It represents a successful example of using a dendrimer as a model for a GPx mimic.
Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. xi@mail.tsinghua.edu.cn
Xi
X
Zhang
Huaping
H
Xu
Zeyuan
Z
Dong
Yapei
Y
Wang
Junqiu
J
Liu
Jiacong
J
Shen
D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
D001555:Benzene Derivatives; D004987:Ethers; D011108:Polymers; D005979:Glutathione Peroxidase