5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations.
Sustainable observations suggest that suicidal behaviour by itself may have biological correlates, among which those related to the serotonergic synapse hold the key position. Based on the association of suicide and serotonergic dysfunction, it was proposed that genetic mechanisms affecting suicidal behaviour could be related to the alterations of the genes encoding the elements of 5HT synapse. The present study tested the association of the polymorphism in the serotonin 2C (5HT-2C) receptor coding region (Cys23Ser) with suicide commitment. Study was based on two independent samples, one of German (284 suicide victims versus 297 controls) and other of Slavic/Croatian (118 suicide victims versus 275 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated. Results did not provide supporting evidence for the potential involvement of the investigated variants of 5HT-2C receptor in the susceptibility to suicide.
Stefulj
Jasminka
J
Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
Büttner
Andreas
A
Kubat
Milovan
M
Zill
Peter
P
Balija
Melita
M
Eisenmenger
Wolfgang
W
Bondy
Brigitta
B
Jernej
Branimir
B
D000328:Adult; D003545:Cysteine / Q000235:genetics; D003710:Demography; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012694:Serine / Q000235:genetics; D013405:Suicide / Q000208:ethnology*; D044465:White People / Q000208:ethnology* / Q000235:genetics
D012333:RNA, Messenger; D044405:Receptor, Serotonin, 5-HT2C; D012694:Serine; D003545:Cysteine