Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya.
Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.
Moormann
A M
AM
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4983, USA. moorms@cwru.edu
Embury
P E
PE
Opondo
J
J
Sumba
O P
OP
Ouma
J H
JH
Kazura
J W
JW
John
C C
CC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000531:Altitude; D002648:Child; D002675:Child, Preschool; D019353:Endemic Diseases; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology* / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007630:Kenya / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000453:epidemiology* / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D012111:Residence Characteristics; D012805:Sickle Cell Trait / Q000453:epidemiology* / Q000235:genetics
D006451:Hemoglobin, Sickle; C028671:hemoglobin AS