Early pregnancy outcomes after chemotherapy for gestational trophoblastic tumor.
OBJECTIVE
To analyze the outcome of the first pregnancy following chemotherapy for gestational trophoblastic tumor (GTT).


METHODS
A total of 393 patients with GTT (87 with high-risk and 306 with low-risk GTT) underwent chemotherapy at Chiba University Hospital between 1974 and 2000. Of them, 137 (19 with high-risk and 118 with low-risk GTT) who achieved primary remission and had at least 1 conception following chemotherapy were included in the study.


RESULTS
The overall outcomes of the first subsequent pregnancies in the 137 women treated with chemotherapy were comparable to those in the general Japanese population. However, the incidence of abnormal pregnancies (spontaneous abortion, stillbirth, repeat mole) was significantly higher in women who conceived within 6 months of completing chemotherapy (6 of 16, 37.5%) than in those who conceived after the recommended waiting period, > 12 months (11 of 99, 10.5%) (P=.014).


CONCLUSIONS
Patients who achieved primary remission with various kinds of chemotherapy may anticipate a normal future reproductive outcome. As pregnancies occurring within 6 months following remission are at risk of abnormality, a waiting period of at least 6 months after chemotherapy for GTT is recommended.
Matsui
Hideo
H
Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. hmatsui@med.m.chiba-u.ac.jp
Iitsuka
Yoshinori
Y
Suzuka
Kiyomi
K
Yamazawa
Koji
K
Tanaka
Naotake
N
Mitsuhashi
Akira
A
Sekiya
Souei
S
D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D011256:Pregnancy Outcome; D013997:Time Factors; D014594:Uterine Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents