[A study of structural rearrangements of chromatin fibrils using the intercalation of ethidium bromide and chloroquine diphosphate].
Structural rearrangements of chromatin resulting from changes in axial twisting of internucleosomal linkers were studied using the intercalators of ethidium bromide and chloroquine diphosphate. It was determined how the modifications of the primary structure affect the compactization of chromatin fibrils. The data obtained suggest that changes in the relative angle of rotation between nucleosomes result in changes in the spatial organization of chromatin fibrils. In this case, the modification of terminal domains can substantially affect the course of this process.
Kraevskiĭ
V A
VA
Lagar'kova
M A
MA
Ausio
H
H
D002738:Chloroquine / Q000737:chemistry*; D002843:Chromatin / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D004587:Electrophoresis, Agar Gel; D004996:Ethidium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells
D002843:Chromatin; D002738:Chloroquine; D004247:DNA; D004996:Ethidium