The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS.
Institute of Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford, United Kingdom.
Andrew E
AE
Timms
Alison M
AM
Crane
Anne-Marie
AM
Sims
Heather J
HJ
Cordell
Linda A
LA
Bradbury
Aaron
A
Abbott
Mark R E
MR
Coyne
Owen
O
Beynon
Ibi
I
Herzberg
Gordon W
GW
Duff
Andrei
A
Calin
Lon R
LR
Cardon
B Paul
BP
Wordsworth
Matthew A
MA
Brown
D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D004252:DNA Mutational Analysis; D017931:DNA Primers; D004587:Electrophoresis, Agar Gel; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015796:HLA-B27 Antigen / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D007375:Interleukin-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D006113:United Kingdom
D017931:DNA Primers; D015796:HLA-B27 Antigen; D007375:Interleukin-1