Diabetes mellitus in itself is not a risk factor for antibiotic resistance in Escherichia coli isolated from patients with bacteriuria.
OBJECTIVE
To investigate whether diabetes mellitus is a risk factor for resistance in Escherichia coli isolated from patients with bacteriuria.


METHODS
Data were obtained from a multicentre study. A clean-voided midstream urine culture was collected from 636 women with diabetes, who were between 18 and 75-years-old, attended an out-patient department and had no symptoms of a urinary tract infection. The resistance of E. coli was determined for different antimicrobials. The results were compared with resistance data from routine isolates of E. coli, obtained from women in the same age category, time period and location.


RESULTS
A total of 135 E. coli were isolated from women with diabetes mellitus (mean age 57 +/- 14 years) and compared with 5907 routine isolates of E. coli obtained from female patients visiting an out-patient department (mean age 52 +/- 17 years). The resistance rates of E. coli isolated from diabetic patients and the routine isolates of E. coli to trimethoprim-sulfamethoxazole were 19% and 23%, respectively, to amoxicillin 16% and 32%, to nitrofurantoin 1% and 3%, to ciprofloxacin 0% and 4%, to ofloxacin 0% and 5%, and to norfloxacin 1% and 4%.


CONCLUSIONS
The resistance of uropathogenic E. coli in non-hospitalized women with diabetes mellitus is not higher than that seen in routine isolates of E. coli. This suggests that diabetes in itself is not a risk factor for resistance.
Department of Acute Medicine & Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands.
R
R
Meiland
S E
SE
Geerlings
A J
AJ
De Neeling
A I M
AI
Hoepelman
D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001437:Bacteriuria / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000627:therapeutic use; D048909:Diabetes Complications; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009582:Nitrofurantoin / Q000627:therapeutic use; D009643:Norfloxacin / Q000627:therapeutic use; D015242:Ofloxacin / Q000627:therapeutic use; D012307:Risk Factors; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009582:Nitrofurantoin; D015242:Ofloxacin; D009643:Norfloxacin