Brunner's gland adenoma of duodenum: a case report and literature review.
OBJECTIVE
To analyze the clinicopathological features of Brunner's gland adenoma of the duodenum.


METHODS
A rare case of Brunner's gland adenoma of the duodenum was described and related literature was reviewed.


RESULTS
Brunner's gland adenoma of the duodenum appeared to be nodular hyperplasia of the normal Brunner's gland with an unusual admixture of normal tissues, including ducts, adipose tissue and lymphoid tissue. We suggested that it might be designated as a duodenal hamartoma rather than a true neoplasm.


CONCLUSIONS
The most common location of the lesion is the posterior wall of the duodenum near the junction of its first and second portions. It can result in gastrointestinal hemorrhage and duodenal obstruction. Endoscopic polypectomy is a worthy treatment for benign Brunner's gland adenomas, as malignant changes in these tumors have never been proven.
Department of Pathology, Affiliated Renji Hospital, Shanghai Second Medical University, 145 Shandong (c) Road, Shanghai 200001, China. jzmgyp@online.sh.cn
Yu-Ping
YP
Gao
Jian-Shan
JS
Zhu
Wen-Jun
WJ
Zheng
D000236:Adenoma; D000328:Adult; D002011:Brunner Glands / Q000473:pathology*; D004378:Duodenal Diseases / Q000473:pathology*; D004386:Duodenum / Q000473:pathology*; D006222:Hamartoma / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D008297:Male