Chron's disease, rare association with selective IgA immunodeficiency, and development of life-threatening bacterial infections.
Life-threatening necrotizing fasciitis and relapsing Lemierre syndrome associated with Fusobacterium necrophorum septicaemia occurred in young adults with a moderate Chron's disease and a missed profound IgA deficiency. This unexpected association of a chronic bowel inflammatory syndrome with prominent IgA abnormalities and severe bacterial infection deserves careful attention by physicians faced with young patients with Chron's disease.
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna 'Alma Mater Studiorum', S. Orsola Hospital, Bologna, Italy. manfredi@med.unibo.it
Roberto
R
Manfredi
Olga V
OV
Coronado
Ginevra
G
Marinacci
Mauro
M
Righi
Leonardo
L
Calza
D000328:Adult; D003424:Crohn Disease / Q000150:complications*; D019115:Fasciitis, Necrotizing / Q000382:microbiology*; D005674:Fusobacterium Infections / Q000382:microbiology*; D005675:Fusobacterium necrophorum / Q000472:pathogenicity; D006801:Humans; D017098:IgA Deficiency / Q000150:complications*; D008297:Male; D000039:Peritonsillar Abscess / Q000382:microbiology; D018805:Sepsis / Q000382:microbiology*; D013577:Syndrome; D020246:Venous Thrombosis / Q000382:microbiology