Studies on a novel safety-catch linker cleaved by Pummerer rearrangement.
We describe the use of a sulfide linkage as a safety-catch linker. This linker is significantly stable to acidic as well as basic conditions and allows transformations to be carried out on solid supports. Moreover, its cleavage is facile by applying Pummerer rearrangement after transforming it to sulfoxide.
Tai
Chih-Ho
CH
Department of Chemistry, National Central University, Chung-Li, Taiwan, 32054.
Wu
Hsiao-Ching
HC
Li
Wen-Ren
WR