Statistical mechanics model for the interaction between the neurotransmitter gamma-aminobutyric acid and GABAA receptors.
Interactions between the neurotransmitter gamma-aminobutyric acid (GABA) and GABAA receptor ion channels play an important role in the central nervous system. A statistical mechanics model is proposed for the interaction between GABA and GABAA receptors. The model provides good fits to the electrophysiology data as well as an estimation of receptor activation energies, and predicts the temperature dependence consistent with measurements. In addition, the model provides insights into single channel conductance measurements. This model is also applicable to other ligand-gated ion channels with similar pentameric structures.
IBM T. J. Watson Research Center, Yorktown Heights, New York 10598, USA.
Sufi
S
Zafar
Nina C
NC
Saxena
Kevin A
KA
Conrad
Arif
A
Hussain
D055592:Biophysical Phenomena; D001703:Biophysics; D015640:Ion Channel Gating / Q000502:physiology; D008024:Ligands; D008956:Models, Chemical; D015233:Models, Statistical; D011963:Receptors, GABA-A / Q000737:chemistry* / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000737:chemistry* / Q000378:metabolism*
D008024:Ligands; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid