[Expression of adrenomedullin and adrenomedullin receptor in the epiretinal membranes of proliferative vitreoretinopathy].
OBJECTIVE
To investigate the expression of adrenomedullin (ADM) and ADM receptor (ADMR) in epiretinal membranes (ERM) of proliferative vitreoretinopathy (PVR).


METHODS
The expression of ADM and ADMR in 10 ERM were studied by in situ hybridization analysis (ISH).


RESULTS
ADM and ADMR mRNAs were expressed in 7 of 10 specimens. The positive signals were distributed unevenly in positive cells. Some cells expressed mainly in the cytoplasm and the others expressed mainly in the nucleus.


CONCLUSIONS
ADM and ADMR are expressed in the ERM of PVR, indicating that ADM and ADMR may play a role in the pathogenesis of PVR.
Institute of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Wei
W
Huang
Lin
L
Wang
Ming
M
Yuan
Ji-xian
JX
Ma
Yan-nian
YN
Hui
D053607:Adrenomedullin / Q000378:metabolism*; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis; D058265:Receptors, Adrenomedullin; D018000:Receptors, Peptide / Q000096:biosynthesis* / Q000235:genetics; D012160:Retina / Q000378:metabolism* / Q000473:pathology; D018630:Vitreoretinopathy, Proliferative / Q000378:metabolism* / Q000473:pathology
D012333:RNA, Messenger; D058265:Receptors, Adrenomedullin; D018000:Receptors, Peptide; D053607:Adrenomedullin