Beta-glucuronidase in physiology and disease.
beta-glucoronidase (EC 3.2.1.31) is a lysosomal enzyme catylysing the decomposition of beta-D-glucoronides--compounds arising as a result of the combination of beta-D-glucoronic acid and a number of compounds both exo- and endogenous, containing hydroxylic, carboxylic, amine, imine or thiol groups. The most common test evaluating the activity of the enzyme is that using phenolphtalein glucoronide as a biosynthetic substrate. The freed aglycons are colorimetrically assayed. The activity of beta-glucoronidase increases in many pathological conditions: liver infammations, cirrhosis of the liver, inflammations of other organs, cholestatic jaundice, tuberculosis, sarcoidosis and also in neoplasms. Many authors point to beta-glucoronidase as a sensitive indicator signalling cell damage.
Department of Biochemistry and Molecular Biology, Medical University of Lublin.
Agnieszka
A
Basińska
Bolesław
B
Floriańczyk
D015415:Biomarkers / Q000032:analysis; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology; D012507:Sarcoidosis / Q000201:enzymology; D014376:Tuberculosis / Q000201:enzymology
D015415:Biomarkers; D005966:Glucuronidase