Effect of leptin on LH and FSH release in ovariectomized rats.
We compared the estradiol/progesterone-induced luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release between normally fed and leptin-supplemented starved ovariectomized female rats and studied also the effect of hyper-leptinaemia on the steroid-induced hormonal release in normally fed ovariectomized rats. Three days' starvation completely abolished steroid-induced LH and FSH release. Significant recovery of the hormonal release was shown in the leptin-supplemented starved group. The magnitudes of LH and FSH release in the normally fed animals with a higher dose of leptin were statistically the same as those in the normally fed group without leptin. These observations indicate that physiological concentrations of circulating leptin exert a stimulatory effect on steroid-induced LH and FSH release.
Department of Physiology, Faculty of Medicine, University of Tanta, Tanta, Egypt.
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Shebl
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D020738:Leptin / Q000494:pharmacology* / Q000502:physiology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D009478:Neuropeptide Y / Q000187:drug effects / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D010052:Ovariectomy; D051381:Rats; D018456:Reproductive Medicine; D013217:Starvation / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors
D020738:Leptin; D009478:Neuropeptide Y; D009569:Nitric Oxide; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone