Synthesis of a mimic for the heterogeneous surface of core 2 sialoglycan-linked glycoprotein.
[structure: see text] An O-glycosylated peptide carrying two core 2 sialopentasaccharides of different glycoform was synthesized as a model of the heterogeneous surface of mucin glycoprotein. Solid-phase synthesis and the subsequent enzymatic sialylation gave two segments, which were coupled by selective thioester activation to produce the title compound.
Takano
Yutaka
Y
Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa, 259-1292, Japan.
Hojo
Hironobu
H
Kojima
Naoya
N
Nakahara
Yoshiaki
Y
D015703:Antigens, CD / Q000737:chemistry; D002384:Catalysis; D006023:Glycoproteins / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D007202:Indicators and Reagents; D051917:Leukosialin; D018716:Molecular Mimicry; D015394:Molecular Structure; D010446:Peptide Fragments / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D012795:Sialoglycoproteins / Q000138:chemical synthesis* / Q000737:chemistry; D012799:Sialyltransferases / Q000378:metabolism
D015703:Antigens, CD; D006023:Glycoproteins; D007202:Indicators and Reagents; D051917:Leukosialin; D010446:Peptide Fragments; C465014:SPN protein, human; D012795:Sialoglycoproteins; D012799:Sialyltransferases