Comparative immunopeptidomics of humans and their pathogens.
Major histocompatibility complex class I molecules present peptides of 8-10 residues to CD8+ T cells. We used 19 predicted proteomes to determine the influence of CD8+ T cell immune surveillance on protein evolution in humans and microbial pathogens by predicting immunopeptidomes, i.e., sets of class I binding peptides present in proteomes. We find that class I peptide binding specificities (i) have had little, if any, influence on the evolution of immunopeptidomes and (ii) do not take advantage of biases in amino acid distribution in proteins other than the concentration of hydrophobic residues in NH(2)-terminal leader sequences.
Celera Genomics, Rockville, MD 20850, USA. sorin.istrail@appliedbiosystems.com
Sorin
S
Istrail
Liliana
L
Florea
Bjarni V
BV
Halldórsson
Oliver
O
Kohlbacher
Russell S
RS
Schwartz
Von Bing
VB
Yap
Jonathan W
JW
Yewdell
Stephen L
SL
Hoffman
D000818:Animals; D005075:Biological Evolution; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D051379:Mice; D010446:Peptide Fragments / Q000276:immunology*; D020543:Proteome
D015395:Histocompatibility Antigens Class I; D008024:Ligands; D010446:Peptide Fragments; D020543:Proteome