[Synthesis and antibacterial activity of 2-(3-pyridyl)-5-([(5-aryl-1,3,4-oxadiazol-2-yl) methylene]thio)-1,3,4-oxadiazoles].
OBJECTIVE
Studies on synthesis and antibacterial activity of new heterocycles.


METHODS
The cyclocondensation of [(3-pyridyl)-1,3,4-oxadiazol-2-yl] thio acetic acid with various aroyl hydrazines in the presence of POCl3 and xylene gave the corresponding titled compounds, and the in vitro antibacterial activity was primarily evaluated by the method of cupplate diffusion solution.


RESULTS
Sixteen novel titled compounds were synthesized, their structures were confirmed by IR, 1HNMR, MS and elemental analysis. Biological screening results demonstrated that most of the compounds prepared displayed potential antibacterial activity.


CONCLUSIONS
Oxadiazoles incorporting pyridyl oxadiazole ring may be usefully antibacterial candidate drugs.
Hu
Guo-qiang
GQ
Medical College of Henan University, Kaifeng 475004, China. hgqxy@sina.com.cn
Xu
Qiu-ju
QJ
Liu
Bao
B
Zhang
Zhong-quan
ZQ
Chen
Bai-quan
BQ
Xu
Qi-tai
QT
Huang
Wen-long
WL
Zhang
Hui-bin
HB
Huang
Sheng-tang
ST
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011514:Proteus vulgaris / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010069:Oxadiazoles