Ligand binding with continuous modification of binding sites.
Simultaneous formulation binding and structure modification of the binding site leads to binding process that can be analyzed within the framework of the non-linear theory of dynamic systems. Such an approach allows us to obtain several properties of the binding center: plurality of stationary (stable and unstable) states at binding, recognition of bistable and hysteretic binding modes. It is also shown that adsorption centre deformation leads to a S-shaped adsorption curve.
Yerevan Physics Institute, Alikhanian Brothers Str.2, Yerevan, 375036 Armenia. arakelv@uniphi.yerphi.am
V B
VB
Arakelyan
S G
SG
Haroutiunian
H H
HH
Abgaryan
A V
AV
Arakelyan
T S
TS
Haroutunyan
D000327:Adsorption; D001665:Binding Sites; D008024:Ligands; D046911:Macromolecular Substances / Q000737:chemistry* / Q000378:metabolism*; D008968:Molecular Conformation; D013816:Thermodynamics
D008024:Ligands; D046911:Macromolecular Substances