[Eosinophil apoptosis in nasal polyposis tissue after bleomycin A5 local injection].
OBJECTIVE
To study the expression of eosinophil in nasal polyposis tissue after Bleomycin A5 local injection.


METHODS
Nineteen cases nasal polyposis specimen obtained before and after treatment with Bleomycin A5 were studied with terminal deoxynucleotidyl transferasemediated dUTP nick endlabeling (TUNEL).


RESULTS
The number of eosinophil in nasal polyposis specimen before treatment is significantly higher than that after treatment (P<0.01) and so to normal inferior turbinate concha mucosa (P<0.01). The apoptosis index (AI) of eosinophil after treatment is significantly higher than that before treatment (P<0.01).


CONCLUSIONS
Eosinophil is the main infiltration cell in nasal polyposis tissue. Bleomycin A5 could cure nasal polyposis by promoting eosinophil apoptosis.
Zhang
Xianghong
X
Department of Otorhinolaryngology, Second Hospital, Xi'an Jiaotong University, Xi'an, 710004, China.
Zou
Jidong
J
Li
Baoshu
B
Ren
Xiaoyong
X
Shi
Ji
J
D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects*; D001761:Bleomycin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D004804:Eosinophils / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000473:pathology*
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C025703:bleomycetin