[Neuromediatorial mechanisms of analgesia during general anesthesia].
Neuromediatorial analysis with an evaluation of the EEG total bioelectric activity of the cortical and subcortical brain structures was performed in rabbits at general anesthesia variants. Naloxone, mu-opioid antagonist, johimbine, alpha2-adrenoceptor antagonist, metisergide, serotoninergic blocker were made use of. The leading role of adrenergic, a less important one of serotoninergic and a minimal one of opioid mechanisms are under discussion within the analgesia status during somatosensory nociception. The adrenergic mechanism is considered to be more important in the development of analgetic effects during visceral nociception versus the opioid or serotoninergic ones.
Zhenilo
M V
MV
Zhenilo
V M
VM
Bychkov
A A
AA
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000698:Analgesia; D000768:Anesthesia, General; D000818:Animals; D004569:Electroencephalography; D005260:Female; D008297:Male; D009292:Narcotic Antagonists / Q000494:pharmacology*; D017288:Pain Threshold / Q000187:drug effects; D011817:Rabbits; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors; D012702:Serotonin Antagonists / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D009292:Narcotic Antagonists; D017981:Receptors, Neurotransmitter; D012702:Serotonin Antagonists