The pH of the secretory pathway: measurement, determinants, and regulation.
The luminal pH of the secretory pathway plays a critical role in the posttranslational modification and sorting of proteins and lipids. The pH of each one of the organelles that constitute the pathway is unique, becoming more acidic as the biosynthetic cargo approaches its destination. The methods used for measurement of pH in the secretory pathway, its determinants, and its regulation are the subjects of this review.
Paroutis
Paul
P
Cell Biology Program, Hospital for Sick Children, Toronto M5G 1X8 Ontario, Canada.
Touret
Nicolas
N
Grinstein
Sergio
S
D000136:Acid-Base Equilibrium / Q000502:physiology*; D000818:Animals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D022142:Secretory Vesicles / Q000502:physiology*; D022161:Transport Vesicles / Q000502:physiology*