MCNP study for epithermal neutron irradiation of an isolated liver at the Finnish BNCT facility.
A successful boron neutron capture treatment (BNCT) of a patient with multiple liver metastases has been first given in Italy, by placing the removed organ into the thermal neutron column of the Triga research reactor of the University of Pavia. In Finland, FiR 1 Triga reactor with an epithermal neutron beam well suited for BNCT has been extensively used to irradiate patients with brain tumors such as glioblastoma and recently also head and neck tumors. In this work we have studied by MCNP Monte Carlo simulations, whether it would be beneficial to treat an isolated liver with epithermal neutrons instead of thermal ones. The results show, that the epithermal field penetrates deeper into the liver and creates a build-up distribution of the boron dose. Our results strongly encourage further studying of irradiation arrangement of an isolated liver with epithermal neutron fields.
Kotiluoto
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VTT Technical Research Centre of Finland, P.O. Box 1608, FIN-02044 VTT, Finland. petri.kotilioto@vtt.fi
Auterinen
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D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000706:statistics & numerical data; D005214:Fast Neutrons / Q000627:therapeutic use; D005387:Finland; D006801:Humans; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D009010:Monte Carlo Method; D019047:Phantoms, Imaging / Q000706:statistics & numerical data; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data