[Comparison of the effectiveness of a mixture of 10% L-arginine and HCl combined with 0.5% Timoptol and with 2% Trusopt: and the individual components on intraocular pressure in an experiment on rabbits].
The presented experimental work is focused to examine effectivity of the amino acid 10% L-arginine x HCl mixture with antiglaucomatic--2% Trusopt (carbonic anhydrase inhibitor) and with 0.5% Timoptol (non-selective beta-blocker) and of the each single compound on intraocular pressure (IOP). In the group of 5 rabbits (New Zealander White) with physiological levels of IOP already the single amino acid L-arginine x HCl decreased the IOP (for 18.4% compared with 0.5% Timoptol and for 9.7% with 2% Trusopt). In case of mixture with the mentioned antiglaucomatics the L-arginine x HCl significantly increases their activity. The showed results indicate the presence of the free amino acids and their interaction with the adequate antiglaucomatic is required for correct action. Based on this interaction a new bio-active metabolite is created (possibly called as "bio-antiglaucomatic").
Veselovský
J
J
Katedra fyziológie a etológie zivocíchov PrF UK, Bratislava.
Oláh
Z
Z
Veselá
A
A
Gressnerová
S
S
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology*; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*
D000959:Antihypertensive Agents; D002257:Carbonic Anhydrase Inhibitors; D004338:Drug Combinations; D013449:Sulfonamides; D013876:Thiophenes; D013999:Timolol; D001120:Arginine; C062765:dorzolamide