Effect of prostaglandin and antiprostaglandin on midcycle myometrial contractions.
To prospectively determine the effects of prostaglandin E(2) and an antiprostaglandin, ibuprofen, on midcycle myometrial contractions, 20 healthy women underwent endovaginal ultrasound to record contractions after receiving these medications. Prostaglandin E(2) stimulated, while ibuprofen inhibited contractions, revealing the important role prostaglandins have on midcycle contractions.
Kenny D
KD
Maslow
Edward A
EA
Lyons
D000293:Adolescent; D000328:Adult; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D009215:Myometrium / Q000187:drug effects / Q000502:physiology*; D018579:Patient Selection; D012016:Reference Values
D016861:Cyclooxygenase Inhibitors; D015232:Dinoprostone; D007052:Ibuprofen