CD8+ T cells reduce in vitro interferon-gamma production in Theiler's murine encephalomyelitis virus-induced demyelinating disease model.
In the Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease model for multiple sclerosis, regulatory CD8+ T cells prevent demyelinating disease and reduce in vivo interferon (IFN)-gamma production by anti-TMEV CD4+ blast cells in BALB/c mice. We describe here that regulatory CD8+ T cells reduce in vitro IFN-gamma production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-beta or tumour necrosis factor-alpha production.
Denton
Paul W
PW
Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203-9037, USA.
Tello
Christina M
CM
Melvold
Roger W
RW
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D018188:Cardiovirus Infections / Q000150:complications*; D016207:Cytokines / Q000096:biosynthesis; D003711:Demyelinating Diseases / Q000378:metabolism* / Q000821:virology*; D004195:Disease Models, Animal; D005260:Female; D007371:Interferon-gamma / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D009103:Multiple Sclerosis; D017945:Theilovirus
D016207:Cytokines; D007371:Interferon-gamma