[RNA localization in the cytoplasm].
RNA localization in subcytoplasmic areas is a process known for more than twenty years, and more than a hundred RNAs have now been shown to be spatially regulated. In most cases, RNA localization is involved in cell polarity, either by reading spatial clues and translating them into a spatial regulation of gene expression, or more directly by controlling cytoskeletal polarity. In this review, the various functions of RNA localization will be presented, and by analyzing two examples, Ash1 mRNA in yeast and retroviral genomic RNAs in mammals, the reader will be taken step by step into the detailed mechanisms of this fascinating process.
IGMM-CNRS UMR 5535, Université Montpellier II, IFR 122, 1919, route de Mende, 34293 Montpellier Cedex 5, France.
Eugenia
E
Basyuk
Brigitte
B
Lavoie
Rémy
R
Bordonné
Edouard
E
Bertrand
D000818:Animals; D003593:Cytoplasm / Q000235:genetics* / Q000648:ultrastructure*; D004268:DNA-Binding Proteins / Q000235:genetics; D012313:RNA; D012333:RNA, Messenger; D012367:RNA, Viral; D012097:Repressor Proteins / Q000235:genetics; D012190:Retroviridae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics
C098733:ASH1 protein, S cerevisiae; D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D012367:RNA, Viral; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D012313:RNA