Engineering of non-natural receptors.
Rational design, usually guided by computational prediction, and selection from libraries of variants of natural proteins have been used with success in the engineering of novel non-natural receptors. Many of these engineered protein binders will find use in biotechnological, diagnostic and medical applications, sometimes in the place of natural antibodies.
Mathonet
Pascale
P
Laboratoire de Biochimie Physique et des Biopolymères, Institut des Sciences de la Vie, place Louis Pasteur 1, B1348 Louvain-la-Neuve, Belgium.
Fastrez
Jacques
J
D001665:Binding Sites; D015374:Biosensing Techniques; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D017076:Computer-Aided Design; D008958:Models, Molecular; D015202:Protein Engineering / Q000379:methods*; D013329:Structure-Activity Relationship
D002352:Carrier Proteins