Clenbuterol induced changes in cholesterol and triglyceride levels of gastrocnemius, pectoralis and heart of rat under work induced stress.
Work induced stress led to decreased cholesterol and fluctuating triglyceride levels in gastrocnemius and pectoralis muscles in rats. But the drug (clenbuterol, 2 mg kg(-1) day(-1)) treatment increased cholesterol and triglyceride levels in both the muscles. However, heart showed decreased cholesterol and increased triglyceride level in the animals under work stress, but at the same time drug treatment led to a significant increase in levels of the two lipid fractions, inferring towards deleterious effect of the drug on heart.
Sharma
Sushma
S
Department of Bio-Sciences, Himachal Pradesh University, Shimla 171 005, India. sushma_bio_sci@rediffmail.com
Garg
Asha
A
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D002976:Clenbuterol / Q000494:pharmacology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
D014280:Triglycerides; D002784:Cholesterol; D002976:Clenbuterol