Genetic analysis of synaptic target recognition and assembly.
Formation of synapses by neurons onto specific targets is essential to the function of a nervous system. The isolation and analysis of Caenorhabditis elegans and Drosophila mutants with synaptogenesis defects has provided insight into the functions of evolutionarily conserved molecules at single-synapse resolution. Importantly, such studies have uncovered novel molecules and signaling mechanisms. Here, recent progress on synaptic target recognition and synaptic assembly are reviewed.
Department of Molecular, Cell and Developmental Biology, Howard Hughes Medical Institute, University of California, Santa Cruz, CA 95064, USA.
Brian D
BD
Ackley
Yishi
Y
Jin
D000818:Animals; D017173:Caenorhabditis elegans; D002450:Cell Communication / Q000235:genetics*; D004330:Drosophila; D008959:Models, Neurological; D008967:Molecular Biology / Q000379:methods; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D013569:Synapses / Q000235:genetics*; D009435:Synaptic Transmission / Q000235:genetics*; D025801:Ubiquitin / Q000502:physiology
D011956:Receptors, Cell Surface; D025801:Ubiquitin