Plasma activity of interleukin-10 in drug-induced cutaneous reactions.
Plasma concentrations of interleukin-10 (IL-10) were examined in 126 patients with drug-induced cutaneous reactions: maculopapular eruptions (ME), erythema multiforme (EM), erythema multiforme coexisting with erythema nodosum (EMN), drug-induced urticaria (DU), hyperergic vasculitis (HV), Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). Activity of the cytokine was measured using the immunoenzymatic ELISA method: a) in the acute stage of disease before treatment was administered, and b) after clearing of skin lesions, after treatment. In the acute stage of disease highly elevated mean concentrations of IL-10 in all 6 groups of patients were found (p<0.001) in comparison with the control. After clearing of clinical symptoms IL-10 concentrations were decreased highly significantly (ME, EM, DU, HV) or significantly (EMN, SJS/TEN) in comparison with the values before treatment, but remained still considerably elevated (p<0.001; p<0.01) when compared with the healthy control. Results of this study indicate that the compensatory antiinflammatory response, expressed as elevated IL-10 activity, is induced as early as in the acute stage of skin lesions and lasts longer than clinical symptoms of drug-induced cutaneous reactions.
Department of Dermatology, Medical University of Lublin.
Grazyna
G
Chodorowska
Dorota
D
Czelej
Dorota
D
Krasowska
Aldona
A
Pietrzak
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004892:Erythema Multiforme / Q000139:chemically induced / Q000276:immunology; D004893:Erythema Nodosum / Q000139:chemically induced / Q000276:immunology; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010267:Parapsoriasis / Q000139:chemically induced / Q000276:immunology; D012871:Skin Diseases / Q000139:chemically induced* / Q000276:immunology*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000276:immunology; D014581:Urticaria / Q000139:chemically induced / Q000276:immunology; D014657:Vasculitis / Q000139:chemically induced / Q000276:immunology
D016753:Interleukin-10