Increased lymphocyte dopamine beta-hydroxylase immunoreactivity in Alzheimer's disease: compensatory response to cholinergic deficit?
There is growing interest in the characterization of peripheral blood lymphocytes (PBL) as a biological tool with which to investigate changes in the neurotransmitter-receptor system in neurodegenerative disorders. Here we show a slight decrease in acetylcholinesterase (AChE) and a significant increase in dopamine beta-hydroxylase (DBH) immunoreactivity in the PBL of patients with probable Alzheimer's disease (AD). Therapy with AChE inhibitors completely reversed the increase in DBH immunoreactivity. We hypothesize that the increase in DBH immunoreactivity may represent a compensatory response to cholinergic impairment. Our findings suggest that neurochemical interactions between the noradrenergic and cholinergic systems may be measured at a peripheral level in AD.
Giubilei
Franco
F
Dipartimento di Scienze Neurologiche, Università di Roma La Sapienza, Roma, Italia. franco.giubilei@uniroma1.it
Calderaro
Caterina
C
Antonini
Giovanni
G
Sepe-Monti
Micaela
M
Tisei
Paolo
P
Brunetti
Ercole
E
Marchione
Francesca
F
Caronti
Brunella
B
Pontieri
Francesco E
FE
D000110:Acetylcholinesterase / Q000172:deficiency*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology* / Q000276:immunology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D004299:Dopamine beta-Hydroxylase / Q000276:immunology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014446:Tyrosine 3-Monooxygenase / Q000172:deficiency
D002800:Cholinesterase Inhibitors; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D000110:Acetylcholinesterase