Vanadyl sulfate ameliorates insulin resistance and restores plasma dehydroepiandrosterone-sulfate levels in fructose-fed, insulin-resistant rats.
OBJECTIVE
To elucidate whether vanadyl sulfate ameliorates the decreased dehydroepiandrosterone sulfate (DHEAS) in hyperinsulinemic rats, we evaluated plasma DHEAS, insulin and triglyceride (TG) levels in fructose-induced, insulin-resistant rats.


METHODS
Animals were divided into three groups: control (C), fructose fed (F-F), and vanadyl-treated fructose fed (F-T). Control animals were fed with standard chow; F-F and F-T groups fed with 66% fructose diet. F-F and C groups received tap water; F-T group received water supplemented with 0.2 mg/ml vanadyl sulfate.


RESULTS
Fasting plasma glucose levels of three groups were comparable. Vanadyl treatment prevented the increase in plasma insulin and TG in the F-T group (P < 0.001) compared with the F-F group. Fructose feeding led to a decrease in plasma DHEAS in the F-F group (P < 0.001) compared with the C group. Vanadyl treatment prevented the decrease in plasma DHEAS in the F-T group (P < 0.001) compared with the F-F group.


CONCLUSIONS
Our results indicated that the hyperinsulinemia in fructose-fed, insulin-resistant rats is associated with low levels of DHEAS. Vanadyl sulfate probably restores plasma DHEAS, due to the improved insulin action.
Harati
Mehdi
M
Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. mharati@medinews.com
Ani
Mohsen
M
D000818:Animals; D001786:Blood Glucose / Q000096:biosynthesis; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005632:Fructose / Q000378:metabolism*; D006946:Hyperinsulinism / Q000378:metabolism; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D015233:Models, Statistical; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism; D017968:Vanadium Compounds / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D014280:Triglycerides; D017968:Vanadium Compounds; D005632:Fructose; D019314:Dehydroepiandrosterone Sulfate; C034028:vanadyl sulfate