Pharmacogenomic considerations of the insertion/deletion gene polymorphism of the angiotensin I-converting enzyme and coronary artery disease.
Gene polymorphisms of components of the renin-angiotensin system, angiotensinogen, angiotensin I-converting enzyme (ACE) and angiotensin II type 1 receptor (AT-1), have been considered to contribute to inherited predisposition towards coronary artery disease (CAD). The best analyzed is the insertion/deletion (I/D) gene polymorphism of the ACE gene. Several studies suggest that the ACE D allele is associated with the occurrence of CAD and myocardial infarction. Moreover, the I/D polymorphism of the ACE gene has been thought to be related to diverse responses to drugs. Modern gene technologies may therefore provide the information, which may help to identify disease-associated genes and determine the responsiveness to a given drug.
Institute of Histology and Embryology, Medical Faculty University of Ljubljana Korytkova 2 SI-1105 Ljubljana, Slovenia. daniel.petrovic@mf.uni-lj.si
Danijel
D
Petrovic
Borut
B
Peterlin
D050197:Atherosclerosis / Q000209:etiology; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000235:genetics*; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000502:physiology; D020521:Stroke / Q000235:genetics
D007703:Peptidyl-Dipeptidase A