Genetics for targeting disease prevention: diabetes.
This article provides an overview of current thinking regarding genetics and diabetes (type 1, type 2, and gestational diabetes mellitus),including a selective look at a few implicated gene variants. This article explores how this information might be applied in current and future clinical practice to (1) predict who is at risk for diabetes and its complications, (2) identify and intervene to prevent or delay the development of diabetes in persons at risk, (3) identify patients with diabetes in an early stage and intervene to prevent later complications,and (4) individualize therapy for patients with diabetes to improve outcomes. The article concludes with some general thoughts about genetics and diabetes prevention in the future.
Oregon State Genetics Program, Oregon Department of Human Services, 800 NE Oregon Street, Suite 825, Portland, OR 97232, USA. astrid.newell@comcast.net
Astrid M
AM
Newell
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000517:prevention & control* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000517:prevention & control* / Q000628:therapy; D016640:Diabetes, Gestational / Q000235:genetics / Q000517:prevention & control; D018450:Disease Progression; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D011320:Primary Health Care; D018570:Risk Assessment