Erythrocyte hyper-aggregation in a patient undergoing orthotopic transplantation for primary sclerosing cholangitis complicated by biliary stricture.
We report on the hemorheological profile of a 16 year old school girl in whom liver transplant was performed due to primary sclerosing cholangitis complicated by biliary stricture. This patient turned out to be of particular hemorheological interest, displaying pre-transplant grossly increased hematocrit-standardized (45%) blood viscosity due to hyperaggregation and elevated plasma viscosity, which is a reflection of elevated immunoglobulins (IgG, IgA and IgM) and alpha-2-macroglobulin. Post-transplant values of rheological parameters were within the normal range for healthy controls.
Department of Neurology, Friedrich-Schiller-University, Philosophenweg 3, 07743 Jena, Germany.
M Akhtar
MA
Anwar
Michael W
MW
Rampling
D000293:Adolescent; D001659:Biliary Tract / Q000473:pathology*; D001809:Blood Viscosity; D015209:Cholangitis, Sclerosing / Q000097:blood* / Q000150:complications / Q000628:therapy; D003251:Constriction, Pathologic; D004903:Erythrocyte Aggregation; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D016031:Liver Transplantation; D000511:alpha-Macroglobulins / Q000032:analysis
D007136:Immunoglobulins; D000511:alpha-Macroglobulins