Coronary artery disease and prevention of heart failure.
Coronary artery disease is a major contributor to the progression of left ventricular systolic dysfunction and heart failure (HF). Recognizing that coronary artery disease is a leading cause of HF in the United States is critical to reducing mortality resulting from this condition. Although some patients may be candidates for mechanical revascularization to improve left ventricular function, all patients are candidates for aggressive secondary prevention strategies. This review discusses the prevalence of coronary artery disease, prognostic significance and pathophysiology, risk factor modifications, pharmacologic treatments, and the role of revascularization.
Klein
Liviu
L
Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. lklein@northwestern.edu
Gheorghiade
Mihai
M
D017677:Age Distribution; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control; D016757:Death, Sudden, Cardiac / Q000209:etiology; D048909:Diabetes Complications; D018450:Disease Progression; D006333:Heart Failure / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D009017:Morbidity; D009204:Myocardial Revascularization; D009765:Obesity / Q000150:complications; D017410:Practice Guidelines as Topic; D015995:Prevalence; D011322:Primary Prevention / Q000379:methods*; D011379:Prognosis; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012907:Smoking / Q000009:adverse effects; D014481:United States; D018487:Ventricular Dysfunction, Left / Q000209:etiology; D020257:Ventricular Remodeling
D002317:Cardiovascular Agents