HLA class II and antibody responses to circumsporozoite protein repeats of P. vivax (VK210, VK247 and P. vivax-like) in individuals naturally exposed to malaria.
We studied the seroreactivity against the circumsporozoite protein (CSP) repeats of Plasmodium vivax variants in individuals living in malaria-endemic area of the Brazilian Amazon region (Candeias do Jamari - RO). The prevalence of IgG antibodies for at least one of the P. vivax CSP repeats was 49%. Among these positive individuals, 34.2% were positive for the standard repeat sequence VK210, 24% for the VK247 and 31.5% for the P. vivax-like sequence. HLA typing showed an association between antibody responses to the CS repeats of VK247 and the presence of HLA-DR16 and between HLA-DR7 and the absence of antibody responses to the CS repeats of VK210. We also investigated the potential relationship between HLA-DQB1 allele profile and antibody response to the CSP repeats of P. vivax but no segregation with responding profile was evidenced. The observed findings indicate that antibody responses to the CSP repeats of P. vivax variants appear to be modulated by HLA class II molecules in malaria naturally exposed individuals.
Laboratório de Pesquisas em Malária, Instituto Oswaldo Cruz - FIOCRUZ, Rio de Janeiro, Brazil. jferrei@rmy.emory.edu
Joseli
J
Oliveira-Ferreira
Lilian R
LR
Pratt-Riccio
Mercia
M
Arruda
Fátima
F
Santos
Cláudio Tadeu
CT
Daniel Ribeiro
Anna Carla
AC
Goldberg
Anna Carla
AC
Golberg
Dalma M
DM
Banic
D000328:Adult; D000818:Animals; D000906:Antibodies / Q000276:immunology; D001938:Brazil / Q000453:epidemiology; D019353:Endemic Diseases; D005802:Genes, MHC Class II / Q000235:genetics*; D005819:Genetic Markers; D006683:HLA-DQ Antigens / Q000276:immunology; D059866:HLA-DQ beta-Chains; D006801:Humans; D016780:Malaria, Vivax / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D008875:Middle Aged; D010966:Plasmodium vivax / Q000276:immunology*; D015800:Protozoan Proteins; D016036:Seroepidemiologic Studies
D000906:Antibodies; D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan