Tcl1 as a model for lymphomagenesis.
Mature leukemias and lymphomas are a heterogeneous group of lymphoproliferative neoplasias characterized by the accumulation of mature lymphocytes in lymph nodes, other lymphoid tissues, and peripheral blood. In this article we discuss molecular mechanisms leading to the pathogenesis of two major types of mature leukemias and lymphomas: mature T-cell leukemia and chronic lymphocytic leukemia.
Pekarsky
Yuri
Y
Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, BLSB 1050, Philadelphia, PA 19107, USA.
Zanesi
Nicola
N
Aqeilan
Rami
R
Croce
Carlo M
CM
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics; D051379:Mice; D023421:Models, Animal; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016415:Sequence Alignment
D011518:Proto-Oncogene Proteins; C090851:TCL1A protein, human