The effect of brachytherapy on antioxidant status and lipid peroxidation in patients with cancer of the uterine cervix.
The aim of this study was to investigate the effect of brachytherapy on lipid peroxidation and antioxidant status in patients with uterine cervix cancer. The study was conducted on 84 uterine cervix cancer patients from the Brachytherapy Department of the Regional Centre of Oncology in Bydgoszcz. Patients with uterine cervix cancer were found to have elevated levels of lipid peroxidation and antioxidant defence system impairment relative to healthy females. The results of the study indicate that brachytherapy has no direct effect on the antioxidant system of patients with uterine cervical carcinoma. However, the normalisation of catalase and glutathione peroxidase activity and erythrocyte TBARS level observed six months after the end of therapy may be due to the arrest of the progression of the disease.
Department of Medical Biology, Ludwik Rydygier Medical University, Karłowicza 24, PL-85-092 Bydgoszcz, Poland. celestyna@go2.pl
Celestyna
C
Mila-Kierzenkowska
Kornelia
K
Kedziora-Kornatowska
Alina
A
Woźniak
Tomasz
T
Drewa
Bartosz
B
Woźniak
Sylwia
S
Drewa
Ewa
E
Krzyzyńska-Malinowska
Roman
R
Makarewicz
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000528:radiation effects*; D001918:Brachytherapy / Q000379:methods*; D002374:Catalase / Q000097:blood / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008875:Middle Aged; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000532:radiotherapy*
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D005979:Glutathione Peroxidase