Bow ties, metabolism and disease.
Highly organized, universal structures underlying biological and technological networks mediate effective trade-offs among efficiency, robustness and evolvability, with predictable fragilities that can be used to understand disease pathogenesis. The aims of this article are to describe the features of one common organizational architecture in biology, the bow tie. Large-scale organizational frameworks such as the bow tie are necessary starting points for higher-resolution modeling of complex biologic processes
Csete
Marie
M
Emory Anesthiology Research Labs, 1462 Clifton Rd NE, Room 420, Atlanta GA 30322, USA. doyle@caltech.edu
Doyle
John
J
D019295:Computational Biology; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism; D004194:Disease / Q000209:etiology*; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D008660:Metabolism / Q000502:physiology*; D008954:Models, Biological; D009747:Nutritional Physiological Phenomena / Q000502:physiology; D049490:Systems Biology
D005947:Glucose