[A new systemic combination chemotherapy to be provided at home for patients with unresectable recurrent colorectal cancer].
We compared the effectiveness of 5-FU + l-LV with CDDP + 5-FU as a systemic chemotherapy for unresectable recurrence of colorectal cancer. The protocol we carried out in one group was as follows: (Group 1) 5-FU 2,000 mg mixed with l-LV 100-200 mg in the disposable balloon pump was administered continuously for 1 week. In the other group, (Group 2) we administered CDDP 5 mg/day every 5 days for a week and continuous 5-FU 500 mg/day for 3 weeks in the hospital, and in the outpatient clinic CDDP 5 mg/day every 2 days for a week with UFT-E 300-600 mg/day, orally, everyday. The response rate of Group 1 was 18.8% and that of Group 2 was 19.3%; the median survival time (MST) was 10.8 months for Group 1 and 8.4 months for Group 2. There were no significant differences between the 2 groups regarding these parameters. Hand foot syndrome (HFS) was observed in 43.8% of the patients, and stomatitis in 37.5% of all cases as adverse effect of systemic chemotherapy using 5-FU + l-LV. But the grade of the adverse effect was low and patients could continue with this systemic chemotherapy.
Takahashi
Keiichi
K
Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
Mori
Takeo
T
Yamaguchi
Tatsuro
T
Matsumoto
Hiroshi
H
Miyamoto
Hidenori
H
Arai
Kuniyoshi
K
Iwasaki
Yoshiaki
Y
Katayanagi
Sou
S
D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D018575:Home Care Services, Hospital-Based; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011379:Prognosis; D013280:Stomatitis / Q000139:chemically induced; D016019:Survival Analysis
D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil