[HLA-Cw alleles polymorphism and haplotypes in Guangdong Han population].
OBJECTIVE
To analyze the polymorphism and haplotypes of HLA-Cw and detect HLA-A, B, Cw and DRB1 allele frequencies in Guangdong Han population.


METHODS
An auto semi-quantitative PCR with reverse sequence-specific oligonucleo- tide was adopted to explore the HLA-A, B, Cw and DRB1 genotypes of 185 bone marrow donors.


RESULTS
Eleven HLA-Cw alleles were obtained in which Cw*03 (0.2580), 07 (0.1887), 01 (0.1732), and 08 (0.1071) had much higher allele frequencies. A total of 7 HLA-Cw-A, 20 HLA-Cw-B and 10 HLA-Cw-DRB1 haplotypes were found.


CONCLUSIONS
HLA-Cw alleles have richer polymorphisms and their linkage disequilibrium with HLA-A, B, DRB1 exhibits geographic genetic characteristics.
Ma
Hong-jing
HJ
Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Xiao
Lu-lu
LL
Yin
Xiao-lin
XL
Guo
Kun-yuan
KY
Ye
Xin
X
D000483:Alleles; D002681:China / Q000208:ethnology; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D015236:HLA-C Antigens