Enhanced blood boron concentration estimation for BPA-F mediated BNCT.
The blood boron concentration regulates directly the BNCT irradiation time in which the prescribed dose to the patient is delivered. Therefore a proper estimation of the blood boron concentration for the treatment field based on the measured blood samples before irradiation is required. The bi-exponential model fit using Levenberg-Marquardt method was implemented for this purpose to provide the blood boron concentration estimates directly to the treatment data flow during the BNCT procedure. The harmonic mean bi-exponential decay half-lives of the studied patient data (n=28) were 15+/-8 and 320+/-70 min for the faster and slower half-life. The model uncertainty (n=28) was reasonably low, 0.7+/-0.1 microg/g (about 5%). The implemented algorithm provides a robust method for temporal blood boron concentration estimation for BPA-F mediated BNCT. Utilization of the infusion data improves the reliability of the estimate. The overall data flow during the treatment fulfills the practical requirements concerning the BNCT procedure.
HUS Helsinki Medical Imaging Center, University of Helsinki, POB 340, FIN-00029 HUS, Finland. mika.kortesniemi@hus.fi
M
M
Kortesniemi
T
T
Seppälä
I
I
Auterinen
S
S
Savolainen
D000465:Algorithms; D001895:Boron / Q000097:blood*; D001896:Boron Compounds / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods / Q000706:statistics & numerical data; D005387:Finland; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000097:blood / Q000532:radiotherapy
C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D005632:Fructose; D001895:Boron