Congenital anophthalmia: a circadian rhythm study.
A circadian rhythm of heart rate and respiratory rate was seen at 1, 8, and 12 months of age in an infant born without ocular tissue, which supports the possibility that the time cues were nonphotic. No melatonin circadian rhythm was detected at any age up to 9 years of age, and this is most likely associated with the anophthalmia and lack of photic input to the suprachiasmatic nucleus. Usually circadian organization is present after the neonatal period and approaches adult levels with development.
Department of Pediatrics, University Hospital, University of Valladolid, Spain. ardura@ped.uva.es
Julio
J
Ardura
Jesus
J
Andres
Maria P
MP
Aragon
Teresa
T
Agapito
D000328:Adult; D000853:Anophthalmos; D001683:Biological Clocks / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007223:Infant; D008550:Melatonin / Q000378:metabolism; D017440:Photoperiod; D012119:Respiration; D012463:Saliva / Q000737:chemistry
D008550:Melatonin