Antiproliferative constituents in plants 14. Coumarins and acridone alkaloids from Boenninghausenia japonica NAKAI.
The MeOH extracts of the ground part and the root of Boenninghausenia japonica NAKAI showed inhibitory activity against tumor cell growth. Fractionation of the extracts has resulted in isolation of 1,3-dihydroxy-4-(2'-hydroxy-3'-hydroxymethyl-3',4'-epoxy-butyl)-N-methylacridone, 1,3-dihydroxy-4-[(Z)-3'-hydroxy-3'-methyl-buten-1'-yl]-N-methylacridone, 3-(1',1'-dimethylallyl)-7-hydroxy-8-methoxy-2H-1-benzopyran-2-one, casegravol, cis-casegravol, and edgeworin in addition to 9 compounds reported from B. japonica and B. albiflora. The isolates from this plant and some related compounds were tested for antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.
Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Norihito
N
Chaya
Kazuko
K
Terauchi
Yuriko
Y
Yamagata
Junei
J
Kinjo
Hikaru
H
Okabe
D000166:Acridines / Q000302:isolation & purification / Q000494:pharmacology*; D054831:Acridones; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D010944:Plants / Q000737:chemistry*
D000166:Acridines; D054831:Acridones; D000470:Alkaloids; D003374:Coumarins; C041300:acridone