The role of profilin complexes in cell motility and other cellular processes.
Profilins are small actin-binding proteins that are essential in all organisms that have been examined to date. In vitro, profilins regulate the dynamics of actin polymerization, which is their key role in vivo during cell motility. However, there is growing evidence that, apart from actin binding, profilins function as hubs that control a complex network of molecular interactions. Profilins interact with a plethora of proteins and the importance of this aspect of their function is just beginning to be understood. In this article, I will summarize recent findings in mammalian cells and mice, and discuss the evidence of a role for profilins in cellular processes such as membrane trafficking, small-GTPase signaling and nuclear activities, in addition to neurological diseases and tumor formation.
Witke
Walter
W
EMBL, Program for Mouse Biology, Campus Adriano Buzzati-Traverso, 00016 Monterotondo, Italy. witke@embl-monterotondo.it
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D003285:Contractile Proteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008024:Ligands; D008840:Microfilament Proteins / Q000737:chemistry / Q000502:physiology*; D051304:Profilins; D011485:Protein Binding / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D003285:Contractile Proteins; D008024:Ligands; D008840:Microfilament Proteins; C495738:PFN1 protein, human; C495745:Pfn4 protein, mouse; D051304:Profilins