[Inhibitive effect of Semen Cassiae on the weight gain in rats with nutritive obesity].
OBJECTIVE
To observe the effect of water extract of Semen Cassiae on the weight gain of nutritive obesity rat.


METHODS
Nutritive obesity model in rats was made by high nutritive diet. Various concentration water extracts of Semen Cassiae were drunk by the rats at physiological state. Weight, metabolism of glucose and lipids, and anti-lipid peroxidation of rats were observed.


RESULTS
6% concentration water extract of Semen Cassiae could significantly reduce the weight and Lee's index, lower the fasting serum levels of triglyceride, insulin and malondialdehyde (MDA).


CONCLUSIONS
Water extract of Semen Cassiae could significantly inhibit the weight gain of high-nutriment-fed rats. The mechanism might be related with its metabolism regulating actions on glucose and lipids.
Lanzhou Medical College, Lanzhou 730000.
Yan
Y
Junbao
Jin
J
Long
Wang
W
Jiangbi
Ding
D
Yonghui
Zheng
Z
Tianzhen
Qu
Q
Songyi
Li
L
Wei
D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology; D002366:Cassia / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D015430:Weight Gain / Q000187:drug effects*
D019440:Anti-Obesity Agents; D004365:Drugs, Chinese Herbal