The biomechanical study of bone of adult rats after application of cisplatine and alpha-aescin.
The experiment proved that cisplatine reduces the mechanical strength of bone by 8.2% as compared to the control group. No significant difference in the increase of bone strength were observed in the group of animals which received alpha-aescin as compared to a control group. Such an increase of bone strength was not confirmed in the case of administration of both cisplatine and alpha-aescin.
Nadulska
Anna
A
Chair and Department of Human Physiology, Medical University of Lublin.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000187:drug effects* / Q000502:physiology; D002945:Cisplatin / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D004928:Escin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000970:Antineoplastic Agents; D004928:Escin; D002945:Cisplatin