Kinetics of virus-specific CD8+ T cells and the control of human immunodeficiency virus infection.
Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be unable to prevent human immunodeficiency virus infection but may have a long-term benefit in controlling viral replication and delaying disease progression. Here we show that analysis of the kinetics of antigen-specific CD8+ T-cell expansion suggests a delay in activation following infection that allows unimpeded early viral replication. Viral kinetics do not differ between controls and vaccinees during this delay phase. An increase in virus-specific CD8+ T-cell numbers around day 10 postinfection coincides with a slowing in viral replication in vaccinees and reduces peak viral loads by around 1 log. However, this response is too little too late to prevent establishment of persistent infection.
Department of Haematology, Prince of Wales Hospital, Kensington, New South Wales, Australia.
Miles P
MP
Davenport
Ruy M
RM
Ribeiro
Alan S
AS
Perelson
D016915:AIDS Vaccines / Q000494:pharmacology; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015683:Gene Products, gag / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D006801:Humans; D016056:Immunodominant Epitopes; D007700:Kinetics; D008253:Macaca mulatta; D018449:SAIDS Vaccines / Q000494:pharmacology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000502:physiology; D013997:Time Factors; D014779:Virus Replication
D016915:AIDS Vaccines; D015683:Gene Products, gag; D016056:Immunodominant Epitopes; D018449:SAIDS Vaccines