Adverse effects of mercuric chloride on thyroid of mice, Musculus albinus and pattern of recovery of the damaged activity.
The protective role of "essentiale phospholipids" (EPL) on mercury induced thyroid dysfunction with special reference to cholesterol, thyroid peroxidase and thyroxine activity in mice were investigated. The animals were treated with 0.5 ml/day of 0.5 ppm aqueous mercuric chloride for a period of 7, 14 and 21 days. For the recovery 175 mg of EPL was given to mice (already treated with HgCl2) for a period of 7, 14 and 21 days. Daily treatment of HgCl2 for 7, 14 and 21 days decreased serum cholesterol, TPO and T4 activity. Simultaneous administration of EPL (25 mg/mice) restored thyroid function in mice by maintaining serum thyroid hormone concentration almost normal. It increased serum cholesterol, TPO and T4 activity. It appears that the protective effect of EPL against HgCl2 induced thyroid dysfunction is mediated through its antioxidative action.
Endocrinology and Physiology Unit, School of Studies in Zoology, Vikram University, Ujjain-456 010, MP, India.
Vishwas
V
Tiwari
Lata
L
Bhattacharya
D000818:Animals; D002784:Cholesterol / Q000097:blood; D007453:Iodide Peroxidase / Q000097:blood; D008627:Mercuric Chloride / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D010743:Phospholipids / Q000008:administration & dosage / Q000378:metabolism; D020127:Recovery of Function / Q000502:physiology*; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013963:Thyroid Hormones / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
D010743:Phospholipids; D013963:Thyroid Hormones; D008627:Mercuric Chloride; D002784:Cholesterol; D007453:Iodide Peroxidase; D013974:Thyroxine