Sucrose ingestion elicits reduced Fos expression in the nucleus accumbens of anhedonic rats.
Chronic mild stress (CMS), an animal model of depression associated with anhedonia, was used to examine nucleus accumbens (NAc) activation associated with a rewarding stimulus. Following 4 weeks of CMS in rats, NAc Fos-immunoreactivity was measured after ingestion of a fixed volume of sucrose. Fewer Fos-positive neurons were observed in the NAc in CMS versus control rats. These findings have implications for the mechanisms underlying reduced responding to pleasurable stimuli associated with depression.
Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, 11 Seashore Hall E, Iowa City, IA 52242-1407, USA.
Angela J
AJ
Grippo
Elisa S
ES
Na
Ralph F
RF
Johnson
Terry G
TG
Beltz
Alan Kim
AK
Johnson
D000818:Animals; D003863:Depression / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D016762:Genes, fos / Q000187:drug effects / Q000502:physiology; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000037:antagonists & inhibitors* / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000008:administration & dosage*
D016760:Proto-Oncogene Proteins c-fos; D013395:Sucrose