Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4.
The capacity of antigen presenting cells to induce anergy in T helper cells and elicit the generation of T suppressor cells is regulated by a variety of positive and negative signals. Antigen-specific CD8(+)CD28(-) and CD4(+)CD25(+) T suppressor/regulatory cells induce the upregulation of inhibitory receptors expressed by antigen-presenting cells (APC) belonging to the family of immunoglobulin-like transcripts (ILTs) and downregulation of costimulatory molecules in APC. Immunoglobulin-like immune inhibitory receptor (ILT4), one of the inhibitory receptors expressed by tolerogenic APC, interacts with human leukocyte antigen A, B, and G molecules and transmits negative signals that interfere with the activation of monocytes and dendritic cells. Reported is the identification of two single nucleotide polymorphisms within domain 1 (IgD1) of ILT4 at positions 113 and 144. Domain 1 is part of the distal membrane portion of ILT4, which is engaged in protein-protein interactions between APC and T cells.
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Nikolaos A
NA
Papanikolaou
Elena R
ER
Vasilescu
Nicole
N
Suciu-Foca
D000483:Alleles; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D005091:Exons / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D017422:Sequence Analysis, DNA
D018076:DNA, Complementary; C491341:LILRB2 protein, human; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D004247:DNA