Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.
Fura
Aberra
A
Bristol Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08534, USA. aberra.fura@bms.com
Shu
Yue-Zhong
YZ
Zhu
Mingshe
M
Hanson
Ronald L
RL
Roongta
Vikram
V
Humphreys
W Griffith
WG
D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System