[Effect of propranolol in silent myocardial ischemia induced by anthracyclines].
Effect of propranolol on pain-free myocardial ischemia induced by exposure to anthracyclinic antibiotics were assessed by findings from Holter ECG monitoring in 36 patients with acute lymphoblast leukemia against the background of a complete clinical-and-hematological remission. In those patients having received small cumulative doses of anthracyclines (less than 550 mg/m2) in whom depression of ST-segment had an apparent tachydependent character the severity of pain-free ischemia was shown to be alleviated by a 3-week intake of propranolol. Remarkably, those patients with "silent" myocardial ischemia having received high cumulative doses of cytostatics (more than 550 mg/m2) did not derive much benefit from beta-adrenoblocker, which fact might be associated with the presence in this case of ischemic episodes unrelated to tachycardia.
Vatutin
N T
NT
Keting
E V
EV
Kalinkina
N V
NV
Dunaeva
O A
OA
Kardashevskaia
L I
LI
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D018943:Anthracyclines / Q000009:adverse effects* / Q000627:therapeutic use; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D018943:Anthracyclines; D011433:Propranolol