Expression of costimulatory molecules B7/CD28 in systemic lupus erythematosus.
The expression of the costimulatory molecules B7/CD28 in peripheral blood mononuclear cells (PBMC) of the patients with systemic lupus erythematosus (SLE) and its relation to the pathogenesis of SLE were studied. The expression of the costimulatory molecules in PBMC in 30 patients with active SLE and 20 cases of healthy controls was detected by using the techniques of immunofluorescence and flow cytometer. The result showed that the expression percentage of CD28+, CD4+ CD28+ in T cells of PBMC from the patients with SLE decreased significantly as compared with that in healthy control group, while the expression percentage of CD80+, CD19+ CD80+ in B cells was significantly increased than that in healthy control group (P<0.01). It suggested that the abnormal expression of costimulatory molecules B7/CD28 played a role in the pathogenesis of SLE.
Department of Rheumatology, Institute of Molecular Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Shaoxian
S
Hu
Deding
D
Tao
Peigen
P
He
D000293:Adolescent; D000328:Adult; D018122:B7-1 Antigen / Q000096:biosynthesis* / Q000235:genetics; D018106:CD28 Antigens / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000209:etiology / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged
D018122:B7-1 Antigen; D018106:CD28 Antigens