Characteristics of BDE dependent on 10B concentration for accelerator-based BNCT using near-threshold 7Li(p,n)7Be direct neutrons.
The characteristics boron-dose enhancer (BDE) was evaluated as to the dependence on the (10)B concentration for BNCT using near-threshold (7)Li(p,n)(7)Be direct neutrons. The treatable protocol depth (TPD) was utilized as an evaluation index. MCNP-4B calculations were performed for near-threshold (7)Li(p,n)(7)Be at a proton energy of 1.900MeV and for a polyethylene BDE. Consequently, the TPD was increased by increasing T/N ratio, i.e., the ratio of the (10)B concentration in the tumor ((10)B(Tumor)) to that in the normal tissue ((10)B(Normal)), and by increasing (10)B(Tumor) and (10)B(Normal) for constant T/N ratio. It has been found that the BDE becomes unnecessary from the viewpoint of increasing the TPD, when (10)B(Tumor) is over a certain level.
Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553, Japan. tanakake@hiroshima-u.ac.jp
K
K
Tanaka
T
T
Kobayashi
G
G
Bengua
Y
Y
Nakagawa
S
S
Endo
M
M
Hoshi
D001608:Beryllium / Q000627:therapeutic use; D001895:Boron / Q000008:administration & dosage*; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D005214:Fast Neutrons / Q000627:therapeutic use; D006801:Humans; D007564:Japan; D008094:Lithium / Q000627:therapeutic use; D009369:Neoplasms / Q000532:radiotherapy; D019047:Phantoms, Imaging; D011868:Radioisotopes / Q000627:therapeutic use; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data
D011868:Radioisotopes; D008094:Lithium; D001895:Boron; D001608:Beryllium