Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens.
Two recombinant Taenia solium oncosphere antigens, designated TSOL18 and TSOL45-1A, were investigated as vaccines to prevent transmission of the zoonotic disease cysticercosis through pigs. Both antigens were effective in inducing very high levels of protection (up to 100%) in three independent vaccine trials in pigs against experimental challenge infection with T. solium eggs, which were undertaken in Mexico and Cameroon. This is the highest level of protection that has been achieved against T. solium infection in pigs by vaccination with a defined antigen. TSOL18 and TSOL45-1A provide the basis for development of a highly effective practical vaccine that could assist in the control and, potentially, the eradication of human neurocysticercosis.
Flisser
Ana
A
Direccion de Investigación, Hospital General Dr. Manuel Gea Gonzalez, SSA, Mexico, DF.
Gauci
Charles G
CG
Zoli
André
A
Martinez-Ocaña
Joel
J
Garza-Rodriguez
Adriana
A
Dominguez-Alpizar
Jose Luis
JL
Maravilla
Pablo
P
Rodriguez-Canul
Rossana
R
Avila
Guillermina
G
Aguilar-Vega
Laura
L
Kyngdon
Craig
C
Geerts
Stanny
S
Lightowlers
Marshall W
MW
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D003551:Cysticercosis / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary; D014612:Vaccines; D014614:Vaccines, Synthetic / Q000008:administration & dosage* / Q000276:immunology
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; C113407:TSOL-18 antigen; D014612:Vaccines; D014614:Vaccines, Synthetic