Association between duration of tirofiban therapy before percutaneous intervention and tissue level perfusion (a TACTICS-TIMI 18 substudy).
In the setting of acute coronary syndromes, thrombotic embolization and activation of platelets with release of vasoconstrictors into the downstream microvasculature may occur before cardiac catheterization. In the Treat Angina with tirofiban and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18 (TACTICS-TIMI 18) trial angiographic substudy, a shorter duration of tirofiban infusion before percutaneous coronary intervention was associated with impaired myocardial perfusion before and after intervention.
Department of Medicine, Brigham & Women's Hospital, 350 Longwood Avenue, Boston, MA 02115, USA. mgibson@timi.org
C Michael
CM
Gibson
Kanwar P
KP
Singh
Sabina A
SA
Murphy
Peter M
PM
DiBattiste
Laura A
LA
Demopoulos
Christopher P
CP
Cannon
Eugene
E
Braunwald
D000368:Aged; D000789:Angina, Unstable / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000191:economics; D015906:Angioplasty, Balloon, Coronary / Q000191:economics; D006328:Cardiac Catheterization / Q000191:economics; D017023:Coronary Angiography / Q000191:economics; D003362:Cost-Benefit Analysis; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000191:economics; D015428:Myocardial Reperfusion Injury / Q000000981:diagnostic imaging / Q000191:economics / Q000517:prevention & control; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D011292:Premedication / Q000191:economics; D015912:Thrombolytic Therapy / Q000191:economics; D000077466:Tirofiban; D016896:Treatment Outcome; D014443:Tyrosine / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000191:economics
D010975:Platelet Aggregation Inhibitors; D014443:Tyrosine; D000077466:Tirofiban