Comparison of serologic responses between Kaposi's sarcoma-positive and -negative men who were seropositive for both human herpesvirus 8 and human immunodeficiency virus.
Although the introduction of HAART decreased substantially the incidence of Kaposi's sarcoma (KS), KS remains the most common cancer among individuals infected with human immunodeficiency virus (HIV). To define markers for progression to KS from the asymptomatic infection of human herpesvirus 8 (HHV-8), serologic responses against HHV-8 were compared between KS-negative and -positive men who were seropositive for both HIV and HHV-8. There was no difference in prevalence of detectable neutralizing antibodies between the two groups. The prevalence of anti-ORF73 antibodies among the dual seropositive patients increased in proportion to their risk of KS. In specimens obtained from 11 HIV+ patients at different intervals over a period of 4-12 years, increase of anti-ORF73 antibody titers was observed in the patients who developed KS but not in the patients who did not develop KS. These results suggest that there is a difference in serologic response against ORF73 between the HIV patients with and without KS.
Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan. ninoue@nih.go.jp
Naoki
N
Inoue
Thomas
T
Spira
Lee
L
Lam
Jose L
JL
Corchero
Wei
W
Luo
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015497:HIV-1; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D009500:Neutralization Tests; D009687:Nuclear Proteins / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000150:complications / Q000276:immunology / Q000503:physiopathology* / Q000821:virology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007074:Immunoglobulin G; D009687:Nuclear Proteins; C109540:latency-associated nuclear antigen