Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cells.
After interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This secretion is dependent on the expression of adenylate cyclase-hemolysin by the bacterium but not on the expression of other characterized bacterial toxins or adhesins. This finding confirms the important role of adenylate cyclase-hemolysin in the pathogenicity of the bacterium.
Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France.
Laurence
L
Bassinet
Catherine
C
Fitting
Bruno
B
Housset
Jean-Marc
JM
Cavaillon
Nicole
N
Guiso
D037361:Adenylate Cyclase Toxin / Q000276:immunology*; D001886:Bordetella pertussis / Q000201:enzymology / Q000472:pathogenicity*; D002460:Cell Line; D004847:Epithelial Cells / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D014132:Trachea / Q000166:cytology / Q000276:immunology* / Q000382:microbiology
D037361:Adenylate Cyclase Toxin; D015850:Interleukin-6