[Effect of light deprivation on homeostasis, life span and development of spontaneous tumors in HER-2/neu transgenic mice].
Twenty five female HER-2/neu transgenic mice (FVB/N), aged 2 months, were surgically deprived of lighting; 30 intact transgenic mice, kept under standard conditions, were in control. Light deprivation was followed by inhibited intake of feed, decreased body mass and delayed age-associated estral disorders, as compared with control. Mean survival rate among experimental mice was higher by 13.5% than in control (p 0.001). Mean life span among the last surviving 10% of the experimental mice was longer than in control by 21.5% while maximum life span--by 21%. Although the number of tumor bearers under 7 months in the study group was twice that in control (p<0.05), they had almost equalized by the end of the experiment. The number of multiple malignancies and the size of tumor and metastases to the lung increased too.
Baturin
D A
DA
Alimova
I N
IN
Popovich
I G
IG
Zabezhinskiĭ
M A
MA
Semenchenko
A V
AV
Iashin
A I
AI
Anisimov
V N
VN
D000818:Animals; D018734:Genes, erbB-2; D006706:Homeostasis; D008027:Light; D051379:Mice; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000473:pathology