Identification of two new HLA-DRB1 alleles: HLA-DRB1*1350 and DRB1*140502.
Two new HLA-DRB1 alleles have been found by using high-resolution sequence-based typing. The two sequences have been officially named DRB1*1350 (HWS10001327-AY048687) and DRB1*140502 (HWS10001790-AY129430). DRB1*1350 differs from DRB1*110101 by two amino acids at positions 37 (Y-->N) and 58 (A-->E). This allele may arise from gene conversion between DRB1*110101 and DRB1*130201 or DRB1*030101, which are commonly found in Taiwan populations. The other allele, DRB1*140502, obtained from a patient with rheumatoid arthritis, differs from DRB1*140501 at codon 58 (GCC-->GCT). However, it causes no change in amino acid sequence and would therefore not have direct clinical implications.
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
Z X
ZX
Chen
S G
SG
Tsan
C W
CW
Dang
C C
CC
Chu
M
M
Lin
Y J
YJ
Lee
D000483:Alleles; D000595:Amino Acid Sequence; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D013624:Taiwan
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen; C497141:HLA-DRB1*13:50 antigen; C497142:HLA-DRB1*14:05:02 antigen