Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy.
This study assessed the impact of coronary vascular adaptive remodeling and coronary vascular reactivity on myocardial ischemia in patients with hypertension and left ventricular hypertrophy. Myocardial ischemia is associated with impaired endothelium-independent vasodilation of resistance coronary arteries and increased minimal coronary resistance. These changes may occur in association with lumen reduction caused by attenuated adaptive remodeling in response to plaque accumulation.
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Tetsuro
T
Kataoka
Shuichi
S
Hamasaki
Sanemasa
S
Ishida
Keishi
K
Saihara
Hideki
H
Okui
Tsuyoshi
T
Fukudome
Takurou
T
Shinsato
Etsuko
E
Mizoguchi
Yuichi
Y
Ninomiya
Yutaka
Y
Otsuji
Shinichi
S
Minagoe
Chuwa
C
Tei
D000109:Acetylcholine; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D002306:Cardiac Volume / Q000502:physiology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D015902:Gamma Cameras; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*; D005996:Nitroglycerin; D010208:Papaverine; D013223:Statistics as Topic; D013794:Thallium Radioisotopes; D018084:Ultrasonography, Interventional; D014655:Vascular Resistance / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology; D014665:Vasodilator Agents; D020257:Ventricular Remodeling / Q000502:physiology*
D013794:Thallium Radioisotopes; D014665:Vasodilator Agents; D010208:Papaverine; D005996:Nitroglycerin; D000109:Acetylcholine