Crescentic glomerulonephritis and dense deposit disease in a woman with breast carcinoma on immunosuppressive chemotherapy.
The authors describe an unusual case of acute renal failure in a 50-year-old woman with a history of breast carcinoma. The breast carcinoma was treated with 4 cycles of chemotherapy. After chemotherapy, she felt fatigued and noticed decreased urine output. Her serum creatinine level had risen from 0.8 to 10.1 mg/dL (71 to 893 micromol/L). Renal biopsy was done that showed a severe crescentic glomerulonephritis secondary to dense deposit disease. This case is extremely unusual in that: (1) Dense deposit disease developed in a 50-year-old woman, whereas it is primarily a disease of children and young adults, and (2) the patient was being treated with immunosuppressive chemotherapy for breast carcinoma when dense deposit disease developed, thus posing a therapeutic dilemma.
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. sanjeev-sethi@uiowa.edu
Sanjeev
S
Sethi
Mandeep
M
Sahani
Liem Som
LS
Oei
Radha
R
Rao
D058186:Acute Kidney Injury / Q000209:etiology*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged
D000970:Antineoplastic Agents