Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma.
BACKGROUND
Valosin-containing protein (VCP) is associated with anti-apoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. In the present study, association of VCP expression with prognosis of gingival squamous cell carcinoma (GSCC) was examined.


METHODS
VCP expression in 74 patients with GSCC (34 males and 40 females) with ages ranging from 42 to 85 (median 66) years was evaluated by immunohistochemistry, in which staining intensity in tumor cells was categorized as either weaker (level 1) or equal to/stronger (level 2) than that in the endothelial cells.


RESULTS
Twenty-four (32.4%) cases showed level 1 and 50 (67.6%) level 2 VCP expression. Patients with level 1 GSCC showed a significantly better 5-year survival rate than those with level 2 GSCC (5-year overall survival: 100% versus 84.9%, P < 0.05). Multivariate analysis revealed VCP expression level, lymph node metastasis and pT(TNM) to be independent factors for overall survival. Patients with GSCC at stages I and II showed favorable prognosis regardless of VCP expression status, whereas at stages III and IV, patients with level 1 VCP expression showed better survival rates than those with level 2 expression.


CONCLUSIONS
Prognostic significance of VCP expression level in GSCC was demonstrated.
Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
S
S
Yamamoto
Y
Y
Tomita
Y
Y
Hoshida
S
S
Toyosawa
H
H
Inohara
M
M
Kishino
M
M
Kogo
M
M
Nakazawa
S
S
Murakami
N
N
Iizuka
S
S
Kidogami
M
M
Monden
T
T
Kubo
N
N
Ijuhin
K
K
Aozasa
D000251:Adenosine Triphosphatases; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D018797:Cell Cycle Proteins / Q000032:analysis*; D005260:Female; D005887:Gingival Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D000074405:Valosin Containing Protein
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D000251:Adenosine Triphosphatases; C000614178:VCP protein, human; D000074405:Valosin Containing Protein