The histologic spectrum of nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) represents a range of histologic lesions in the liver that occur in individuals who do not consume alcohol in quantities that generally are considered to be harmful. The histologic spectrum of NAFLD includes isolated predominantly macrovesicular steatosis alone at one end and steatohepatitis at the other. Nonalcoholic steatohepatitis can progress to cirrhosis and now also is considered to be a precursor of cryptogenic cirrhosis. This article provides an understanding of the histologic features of NAFLD and the potential pitfalls in the histologic assessment of this condition.
Contos
Melissa J
MJ
Department of Pathology, Virginia Commonwealth University, Box 980662, Richmond, VA 23298, USA. mcontos@hsc.vcu.edu
Choudhury
Jayanta
J
Mills
A Scott
AS
Sanyal
Arun J
AJ
D000410:Alanine Transaminase / Q000097:blood; D001706:Biopsy; D005234:Fatty Liver / Q000201:enzymology / Q000473:pathology*; D022781:Hepatocytes / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008103:Liver Cirrhosis / Q000201:enzymology / Q000473:pathology
D000410:Alanine Transaminase