S-nitroso human serum albumin improves oxygen metabolism during reperfusion after severe myocardial ischemia.
Nitric oxide (NO) supplementation may modify myocardial oxygen consumption and vascular function after ischemia. We investigated the effects of the NO donor, S-nitroso human serum albumin (S-NO-HSA), on cardiac oxygen metabolism during controlled reperfusion on normothermic cardiopulmonary bypass after severe myocardial ischemia. Pigs randomly received either S-NO-HSA or human serum albumin prior to and throughout global myocardial ischemia. Myocardial oxygen utilization is impaired at the onset of reperfusion, which is not amenable to S-NO-HSA. However, NO supplementation during ongoing supply dependency of oxygen consumption eventually leads to greater myocardial oxygen delivery and consumption. In conjunction with a better washout of lactate, this indicates an improved capillary perfusion in the S-NO-HSA group during reperfusion, which results in a better contractile function post bypass.
Division of Cardiothoracic Anesthesia and Intensive Care, University Hospital Vienna, Vienna, Austria. martin.dworschak@univie.ac.at
Martin
M
Dworschak
Maximilian
M
Franz
Seth
S
Hallström
Severin
S
Semsroth
Harald
H
Gasser
Markus
M
Haisjackl
Bruno K
BK
Podesser
Tadeusz
T
Malinski
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D017202:Myocardial Ischemia / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D009603:Nitroso Compounds; D010101:Oxygen Consumption / Q000187:drug effects; D011446:Prospective Studies; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D013552:Swine
D020030:Nitric Oxide Donors; D009603:Nitroso Compounds; C091665:S-nitrosoalbumin; D012710:Serum Albumin, Bovine; D009569:Nitric Oxide