Cortical networks generating movement-related EEG rhythms in Alzheimer's disease: an EEG coherence study.
Patients with mild Alzheimer's disease (AD) present with abnormally strong values of frontal and ipsilateral central sensorimotor rhythms. The authors tested 2 working hypotheses of the related electroencephalographic (EEG) coherence: disconnection, defined as a sign of a reduced coordination within the frontoparietal and interhemispheric networks, and cooperation, defined as a reflection of the reorganization of the brain sensorimotor networks. Results showed that, compared with healthy controls, patients with mild AD had an unreactive and abnormally low interhemispheric EEG coherence and an unreactive and abnormally high frontoparietal EEG coherence. These findings support the hypothesis of an impaired mechanism of sensorimotor cortical coupling (disconnection) in mild AD.
Dipartimento Fisiologia Umana e Farmacologia, Università degli Studi di Roma "La Sapienza', Rome, Italy. claudio.babiloni@uniroma1.it
Claudio
C
Babiloni
Carlo
C
Miniussi
Davide V
DV
Moretti
Fabrizio
F
Vecchio
Serenella
S
Salinari
Giovanni
G
Frisoni
Paolo Maria
PM
Rossini
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D012815:Signal Processing, Computer-Assisted