Current status of fluorescent in-situ hybridisation.
Several modifications have taken place in fluorescent in-situ hybridisation (FISH) techniques, including comparative genomic hybridisation, primed in-situ labelling, interphase FISH, multicolour FISH and in combination with peptide nucleic acid technology. FISH can also be combined with microarrays. Selected innovative technologies are described. The most clinically important applications are in cytogenetics and oncology.
Jain PharmaBiotech, Basel, Switzerland. jain@pharmabiotech.ch
K K
KK
Jain
D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism*; D020223:Chromosome Painting / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D015342:DNA Probes; D004867:Equipment Design; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D013673:Technology Assessment, Biomedical
D014408:Biomarkers, Tumor; D015342:DNA Probes