Pericarditis and polyserositis as a side effect of clozapine in an adolescent girl.
A case report describes an adolescent girl with a treatment-resistant bipolar disorder, who developed pericarditis and polyserositis while being treated with clozapine. The sparse literature about this rare, severe side effect of clozapine is discussed. Clinical recommendations with regard to monitoring are given. If myocarditis/polyserositis occurs, clozapine has to be discontinued immediately.
Branik
Emil
E
Klinik Sonnenhof, Kinder- und Jugendpsychiatrisches Zentrum, CH-9608 Ganterschwil SG, Switzerland. emil.branik@kjpz.ch
Nitschke
Meike
M
D000293:Adolescent; D000380:Agranulocytosis / Q000139:chemically induced / Q000150:complications; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010493:Pericarditis / Q000139:chemically induced* / Q000150:complications; D011569:Psychiatric Status Rating Scales; D012700:Serositis / Q000139:chemically induced* / Q000150:complications
D014150:Antipsychotic Agents; D003024:Clozapine