Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens.
Two recombinant Taenia solium oncosphere antigens, designated TSOL18 and TSOL45-1A, were investigated as vaccines to prevent transmission of the zoonotic disease cysticercosis through pigs. Both antigens were effective in inducing very high levels of protection (up to 100%) in three independent vaccine trials in pigs against experimental challenge infection with T. solium eggs, which were undertaken in Mexico and Cameroon. This is the highest level of protection that has been achieved against T. solium infection in pigs by vaccination with a defined antigen. TSOL18 and TSOL45-1A provide the basis for development of a highly effective practical vaccine that could assist in the control and, potentially, the eradication of human neurocysticercosis.
Direccion de Investigación, Hospital General Dr. Manuel Gea Gonzalez, SSA, Mexico, DF.
Ana
A
Flisser
Charles G
CG
Gauci
André
A
Zoli
Joel
J
Martinez-Ocaña
Adriana
A
Garza-Rodriguez
Jose Luis
JL
Dominguez-Alpizar
Pablo
P
Maravilla
Rossana
R
Rodriguez-Canul
Guillermina
G
Avila
Laura
L
Aguilar-Vega
Craig
C
Kyngdon
Stanny
S
Geerts
Marshall W
MW
Lightowlers
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D003551:Cysticercosis / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary; D014612:Vaccines; D014614:Vaccines, Synthetic / Q000008:administration & dosage* / Q000276:immunology
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; C113407:TSOL-18 antigen; D014612:Vaccines; D014614:Vaccines, Synthetic