[Evaluation of telomerase activation in laryngeal mucosa adjacent to carcinoma].
OBJECTIVE
To investigate telomerase activity in laryngeal nonmalignant mucosa adjacent to carcinoma and discuss its effect on extension and recurrence of laryngeal carcinoma.


METHODS
Telomerase repeat amplification protocol was used and combined with histological examination.


RESULTS
The positive percentage of telomerase activation was even higher in laryngeal nonmalignant mucosa distant toward surgically negative margin of carcinoma than in laryngeal carcinomas themselves (P<0.05).


CONCLUSIONS
Telomerase activation occurred probably before the morphologic alteration, which may imply expansion of the cells with potential of malignant transformation.
Department of Otolaryngology, Second Affiliated Hospital of Medical School, Zhejiang University, Hangzhou, 310009, China.
Ming
M
Chen
Beibei
B
Yang
Xing
X
Zhang
D000328:Adult; D000368:Aged; D006801:Humans; D007820:Laryngeal Mucosa / Q000201:enzymology*; D007822:Laryngeal Neoplasms / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D019098:Telomerase / Q000378:metabolism*
D019098:Telomerase