Fosinopril and amlodipine in the treatment of isolated systolic hypertension.
The aim of this study was to assess the therapeutic effects of fosinopril (F) and amlodipine (A) on regulation and circadian rhythm of blood pressure, and to evaluate left ventricle mass index (LVMI) in patients over 60 years of age with isolated systolic hypertension, after three months of administration period. After one-week placebo run-in period, 60 patients were randomized into two groups, each including 30 patients, to receive either fosinopril or amlodipine for three months. Clinical, echocardiographic examinations and 24 h ambulatory blood pressure measurements were performed at baseline, and after 3 months of therapy. The goal blood pressure was < or = 140/90 mmHg. It was accomplished in more than two thirds of cases (F 76.6%, and A 79.9%), with lower drug doses needed in the group treated with F. In 13 patients goal values were not accomplished, therefore the therapy was prolonged for one additional month, with combination of two drugs. In 10 of these patients (76.9%), adequate regulation of blood pressure was achieved. Both fosinopril and amlodipine efficiently control blood pressure by once-a-day administration, both significantly influencing its circadian rhythm and resulting in regression of myocardial hyperthrophy. Adequate control of blood pressure and beneficial effects on circadian rhythm of blood pressure are achieved with lower doses of fosinopril.
Katica
K
Pavlović
Dragan
D
Benc
Jasna
J
Kmezić-Grujin
Jadranka
J
Stojiljković
Nadica
N
Cemerlić-Adić
Tatjana
T
Miljković
Piroska
P
Mesaros
D017311:Amlodipine / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005260:Female; D017328:Fosinopril / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D017311:Amlodipine; D017328:Fosinopril