The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba.
OBJECTIVE
To assess the safety and efficacy of the 308-nm excimer laser in pigment correction of hypopigmented scars and striae alba.


METHODS
Institutional review board-approved randomized controlled trial.


METHODS
Private research center.


METHODS
Volunteer sample of 31 adult subjects with hypopigmented scars or striae alba distributed on the face, torso, or extremities.


METHODS
Lesions were randomized to receive treatment or not, with site-matched normal control areas. Treatments were initiated with a minimal erythema dose minus 50 mJ/cm(2) to affected areas. Subsequent treatments were performed biweekly until 50% to 75% pigment correction, then every 2 weeks thereafter until a maximum of 10 treatments, 75% increase in colorimetric measurements, or 100% visual pigment correction.


METHODS
Pigment correction by visual and colorimetric assessments compared with untreated control lesions and site-matched normal skin before each treatment and at 1-, 2-, 4-, and 6-month follow-up intervals. Occurrence of erythema, blistering, dyspigmentation, or other adverse effects was monitored.


RESULTS
The percentage pigment correction by both assessments increased in direct proportion to the number of treatments. The mean percentage pigment correction by visual assessment relative to control of 61% (95% confidence interval [CI], 55%-67%) for scars and 68% (95% CI, 62%-74%) for striae was achieved after 9 treatments. The mean percentage pigmentation by colorimetric measurements relative to control of 101% (95% CI, 99%-103%) for scars and 102% (95% CI, 99%-104%) for striae was achieved after 9 treatments. Both sets of values gradually declined toward baseline levels during the 6-month follow-up. No blistering or dyspigmentation occurred.


CONCLUSIONS
Therapy with the 308-nm excimer laser is safe and effective in pigment correction of hypopigmented scars and striae alba. Mean final pigment correction rates relative to control sites of approximately 60% to 70% by visual assessment and 100% by colorimetric analysis were observed after 9 treatments administered biweekly. Maintenance treatment every 1 to 4 months is required to sustain the cosmetic benefit.
Alexiades-Armenakas
Macrene R
MR
Laser & Skin Surgery Center of New York, NY, USA. dralexiades@nyderm.org
Bernstein
Leonard J
LJ
Friedman
Paul M
PM
Geronemus
Roy G
RG
D000005:Abdomen; D000328:Adult; D002921:Cicatrix / Q000473:pathology / Q000532:radiotherapy*; D005121:Extremities; D005145:Face; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000473:pathology / Q000532:radiotherapy*; D028022:Low-Level Light Therapy; D008297:Male; D013909:Thorax; D016896:Treatment Outcome