Post-interval syndrome after carbon monoxide poisoning.
Carbon monoxide (CO) exposure and toxicity is a potentially lethal disorder with immediate and delayed side effects. A 24-y-old driver was admitted to the University-based emergency department with altered mental status. He was found unconscious in the driver's seat of his vehicle in an indoor garage the morning before. An estimated 7 h later, he was comatose and taken to a nearby village clinic. Oxygen was administered immediately. Later, he was transferred to the university hospital. At the 12th h after exposure, the Glasgow Coma Scale score was 12/15 (E3, M5, V4). Co-oximetry disclosed a carboxyhemoglobin concentration of 10.5%. Normobaric oxygen was administered. He recovered completely the 3rd d after exposure; however, on the 7th d disorientation and agitation was noted, and the interval form of CO poisoning and leukoencephelopaty were suspected, for which he was readmitted the 10th d after exposure. Analysis of cerebrospinal fluid and blood revealed no abnormalities. Magnetic resonance imaging on the 11th d after exposure demonstrated an ischemic area in the posterior temporoparietal area. The patient continued improvement to discharge at 7th d of the second admission. Close follow-up should be scheduled for CO-poisoned patients to rule out the post-interval syndrome for at least 1 mo. This should also include those with apparent clinical and laboratory recovery.
Department of Emergency Medicine, Ataturk University, School of Medicine, Erzurum, Turkey.
Sahin
S
Aslan
Ozgur
O
Karcioglu
Fatih
F
Bilge
Mehmet
M
Meral
Zulal
Z
Ozkurt
Mustafa
M
Uzkeser
D000328:Adult; D002249:Carbon Monoxide Poisoning / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004638:Emergency Treatment; D015600:Glasgow Coma Scale; D006801:Humans; D002534:Hypoxia, Brain / Q000209:etiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010102:Oxygen Inhalation Therapy; D014474:Unconsciousness / Q000209:etiology / Q000473:pathology