Octopamine modulates the axons of modulatory projection neurons.
Octopamine increases the cycle frequency of the pyloric rhythm in the crab Cancer borealis by acting at multiple sites within the stomatogastric nervous system. The junction between the stomatogastric nerve (stn) and the superior esophageal nerve (son) shows synaptic structures. When applied only to the stn-son junction, octopamine induced action potentials in the axons of the modulatory commissural neuron 5 (MCN5) that project from the commissural ganglia to the stomatogastric ganglion (STG). The activation of the MCN5 neurons was correlated with an increase in the pyloric rhythm frequency. Additionally, octopamine had direct effects on the STG, including the activation of the pyloric dilator and pyloric neurons, an increase in the pyloric frequency, and a change in the phase relationships of the pyloric neurons. Thus, the same modulator can influence the pyloric rhythm by acting at multiple sites, including the axons of identified modulatory neurons that project to the STG. These data demonstrate that axonal propagation may be influenced locally by neuromodulators acting on axonal receptors, therefore altering the conduction of information from different command and integrating centers.
Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02454, USA.
Jean-Marc
JM
Goaillard
David J
DJ
Schulz
Valerie L
VL
Kilman
Eve
E
Marder
D000200:Action Potentials; D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000502:physiology; D003386:Brachyura; D004064:Digestive System / Q000294:innervation; D004525:Efferent Pathways / Q000166:cytology / Q000502:physiology / Q000648:ultrastructure; D017952:Ganglia, Invertebrate / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D009424:Nervous System Physiological Phenomena / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D009655:Octopamine / Q000494:pharmacology* / Q000502:physiology; D010507:Periodicity
D009655:Octopamine