Lack of association of a 9 bp insertion/deletion polymorphism within the bradykinin 2 receptor gene with myocardial infarction.
The BK (bradykinin) B2 receptor is the major cellular mediator of the effects of BK. A 9 bp deletion in the promoter of the receptor gene represents an allelic variant that is associated with enhanced mRNA expression levels. We tested whether this polymorphism is associated with the prevalence of MI (myocardial infarction) or with echocardiographically determined left ventricular function in post-MI patients. Patients with documented MI (n=484), matched controls and controls without evidence of coronary heart disease (n=1363) constituted cases and controls. MI patients and controls were carefully matched for age, gender and cardiovascular risk factors. Genotype distributions of the 9 bp insertion/deletion polymorphism were similar across the groups: -9/-9, -9/+9 and +9/+9 were 22.1, 49.5 and 28.5% in MI patients, and 23.0, 44.6 and 32.5% in matched control subjects respectively. The lack of association was also observed in selected subgroups, stratified by age, gender and cardiovascular risk factors. Furthermore, there was no relation between this polymorphism and left ventricular systolic function in post-MI patients. These findings indicate that the 9 bp insertion/deletion polymorphism of the BK B2 receptor gene is neither related to the prevalence of MI nor to left ventricular function after MI.
Fischer
Marcus
M
Clinic for Internal Medicine 2, University of Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany.
Lieb
Wolfgang
W
Marold
Daniel
D
Berthold
Matthias
M
Baessler
Andrea
A
Lowel
Hannelore
H
Hense
Hans-Werner
HW
Hengstenberg
Christian
C
Holmer
Stephan
S
Schunkert
Heribert
H
Erdmann
Jeanette
J
D000328:Adult; D000368:Aged; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D043782:Receptor, Bradykinin B2 / Q000235:genetics*; D016277:Ventricular Function, Left / Q000235:genetics
D043782:Receptor, Bradykinin B2