Pyrrole syntheses based on titanium-catalyzed hydroamination of diynes.
Titanium-catalyzed hydroamination of 1,4- and 1,5-diynes by primary amines leads to imino-alkynes that undergo in situ 5-endo dig and 5-exo dig cyclization reactions, respectively. The products are 1,2,5-trisubsituted pyrroles accessed directly from readily available diyne starting materials.
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Balasubramanian
B
Ramanathan
Adam J
AJ
Keith
Douglas
D
Armstrong
Aaron L
AL
Odom