[Interactions between foodstuffs and statins].
The existence of interactions between different drugs or between drugs and the diet is becoming better and better known. Statins are medicines currently in widespread use for the treatment of hyperlipidaemias. Diet has a great influence on the prevention and/or treatment of these pathologies as the therapeutic strategy used comprises appropriate diet and, if this does not succeed, pharmacological therapy is begun in combination with dietary advice. For this reason it is necessary to be aware of the potential interactions between this kind of medication and foodstuffs in order to avoid alterations in the therapeutic benefits and even the onset of adverse side effects. All of the statins are absorbed orally, so the impact of food intake on administration is extremely important to achieve an appropriate therapeutic effect. Many of the interactions of statins lie in their metabolism through cytochrome P-450 (except for pravastatin), thus making them candidates for interaction with certain foodstuffs or compounds contained in them, such as in the case of grapefruit juice. This paper reviews the drug-nutrient interactions with special attention to the interactions specific to statins and the mechanism of these interactions is described so as to contribute to their avoidance and thus improve this form of treatment in individuals with hyperlipidaemia.
Servicio de Farmacia, Hospital Severo Ochoa, Leganés. eduperedaca2@mi.madritel.es
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Lucena
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D000042:Absorption; D001628:Beverages; D032083:Citrus paradisi; D000431:Ethanol / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology; D018565:Food-Drug Interactions; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000378:metabolism*
D005227:Fatty Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000431:Ethanol