Combinatorial control of gene expression.
Revealing the molecular principles of eukaryotic transcription factor assembly on specific DNA sites is pivotal to understanding how genes are differentially expressed. By analyzing structures of transcription factor complexes bound to specific DNA elements we demonstrate how protein and DNA regulators manage gene expression in a combinatorial fashion.
Reményi
Attila
A
Gene Expression Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. remenyi@itsa.ucsf.edu
Schöler
Hans R
HR
Wilmanns
Matthias
M
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D019281:Dimerization; D005786:Gene Expression Regulation; D024002:HMGB Proteins; D006801:Humans; D008957:Models, Genetic; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000378:metabolism; D050811:Octamer Transcription Factor-1; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism
D004268:DNA-Binding Proteins; D024002:HMGB Proteins; D009687:Nuclear Proteins; D050811:Octamer Transcription Factor-1; C494165:POU2F1 protein, human; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors; D004247:DNA