Reactogenicity of acellular pertussis vaccine in 4-year-olds in The Netherlands.
OBJECTIVE
To observe reactogenicity of a three-component acellular pertussis (aP) vaccine simultaneously given with dT-IPV vaccine at the age of 4 years.


RESULTS
Of 813 subjects 36% had no adverse events. At the first day the score for pain was 47-55% (aP versus dT-IPV), for redness 3-4% and for swelling 5-6%. Irritability and loss of appetite had a score of 20%. In 3% of the children fever was present. Most symptoms disappeared within 3 days.


CONCLUSIONS
Boostervaccination with an aP vaccine simultaneously given with dT-IPV vaccine at the age of 4 years is well tolerated.
Keijzer-Veen
Mandy G
MG
Erasmus MC-Sophia Children's Hospital, Room SP 2456, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands.
Holty-van der Wekken
Lianne
L
Juttmann
Rikard E
RE
de Groot
Ronald
R
Rümke
Hans C
HC
D002675:Child, Preschool; D003625:Data Collection; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000009:adverse effects / Q000276:immunology; D004487:Edema / Q000453:epidemiology / Q000209:etiology; D004890:Erythema / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects; D007273:Injections, Intramuscular / Q000009:adverse effects; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010146:Pain / Q000453:epidemiology / Q000209:etiology; D010567:Pertussis Vaccine / Q000009:adverse effects* / Q000276:immunology; D011795:Surveys and Questionnaires; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control
D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D010567:Pertussis Vaccine