Do surface-active lipids in food increase the intestinal permeability to toxic substances and allergenic agents?
The incidence of many common diseases has increased during the last decades. High fat intake is a risk factor for many diseases. We propose that some of the negative effects of fat are caused by lipid-induced damage of the gastrointestinal epithelium, thus compromising the epithelial function as a barrier for passage of toxic substances and allergenic agents to the circulatory system. Monoglycerides (MGs), phospholipids and fatty acids (FAs) are surface-active molecules that in pharmaceutical studies act as permeability enhancers for hydrophilic drugs with low absorption. Three possible mechanisms were proposed: (a) lipid-induced alterations in intracellular events may cause destabilization of tight junctions between the GI epithelial cells, (b) lipids may destabilize cell membranes, (c) lipids cause intestinal cell damage, which increase the permeability of the GI epithelium. These "side effects" of lipids may partly explain the association between fat intake and disease observed in epidemiological studies.
Toxicology Division, National Food Administration, P.O. Box 622, S-751 26, Uppsala, Sweden. nils-gunnar.ilback@slv.se
N-G
NG
Ilbäck
M
M
Nyblom
J
J
Carlfors
B
B
Fagerlund-Aspenström
S
S
Tavelin
A W
AW
Glynn
D000284:Administration, Oral; D000485:Allergens / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects* / Q000502:physiology*; D002986:Clinical Trials as Topic; D004041:Dietary Fats / Q000009:adverse effects; D019317:Evidence-Based Medicine; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D008055:Lipids / Q000008:administration & dosage*; D008954:Models, Biological; D011042:Poisons / Q000493:pharmacokinetics* / Q000633:toxicity; D013501:Surface-Active Agents / Q000008:administration & dosage*
D000485:Allergens; D004041:Dietary Fats; D008055:Lipids; D011042:Poisons; D013501:Surface-Active Agents