[Early-stage changes of caliber and blood flow of cat pial microvessels following craniocerebral missile wound].
OBJECTIVE
To investigate the early-stage changes of cerebral microcirculation after craniocerebral missile wound (CMW) in cats.


METHODS
Twelve mongrel cats of either sex were used for measuring the caliber (D), velocity (V) and blood flow (Q) of the pial microvessels and observing the vital signs 10 min before CMW and from 5 min to 5 h after CMW. The pathological changes of the brain tissue were also examined.


RESULTS
After CMW, the D, V and Q of the pial arteriole decreased within the initial 5 to 20 min, followed by elevation of Da and Qa at 90 min. No significant changes were noted in the Dv of the pial venule but its Vv and Qv remained at low levels.


CONCLUSIONS
After CMW, the Q of microvessels may increase progressively in the areas of concussion, contusion and laceration injuries to induce reperfusion injury following ischemia and hypoxia of the brain tissue resulting from microcirculation disorder caused by the wound.
Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, China. wangfant@sohu.com
Fan
F
Wang
Chang-cai
CC
Chen
Bo-yong
BY
Mao
Chao
C
You
Ru-xiang
RX
Xu
D000818:Animals; D001783:Blood Flow Velocity; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002196:Capillaries / Q000473:pathology / Q000502:physiology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D008297:Male; D010841:Pia Mater / Q000098:blood supply*; D014948:Wounds, Gunshot / Q000473:pathology / Q000503:physiopathology*