Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging.
Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.
Kennedy Krieger Institute, Baltimore, Maryland, USA.
Lidia M
LM
Nagae-Poetscher
Michael
M
McMahon
Nancy
N
Braverman
William T
WT
Lawrie
Ali
A
Fatemi
Mahaveer
M
Degaonkar
Alena
A
Horská
Martin G
MG
Pomper
Vaddapuram P
VP
Chacko
Peter B
PB
Barker
D000328:Adult; D002552:Cerebral Ventricles / Q000378:metabolism*; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D002648:Child; D003067:Coenzymes / Q000172:deficiency; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008667:Metalloproteins / Q000172:deficiency; D000090006:Molybdenum Cofactors; D011522:Protons; D011621:Pteridines; D012640:Seizures / Q000175:diagnosis
D003067:Coenzymes; D008667:Metalloproteins; D000090006:Molybdenum Cofactors; D011522:Protons; D011621:Pteridines; C022261:molybdopterin