Inhibitory effect of topical applications of nondenatured soymilk on the formation and growth of UVB-induced skin tumors.
Treatment of female SKH-1 hairless mice with ultraviolet B light twice a week for 20 weeks resulted in a population of tumor-free mice with a high risk of developing skin tumors during the next several months in the absence of additional UVB treatment (high-risk mice). Topical applications of nondenatured soymilk but not heat-denatured soymilk once a day, 5 days a week to these high-risk mice inhibited the formation and growth of skin tumors. Similar topical applications of soybean trypsin inhibitor or Bowman-Birk inhibitor also inhibited the formation and growth of skin tumors, but these agents were less active than nondenatured soymilk. Treatment of miniswine skin with nondenatured soymilk once a day for 5 days prior to UVB irradiation reduced or completely eliminated UVB-induced formation of thymine dimers and apoptotic cells in the epidermis. These data suggest that nondenatured soymilk could be applied to humans to prevent sunlight-induced skin damage and to reduce the risk of skin tumor formation and progression.
Huang
Mou-Tuan
MT
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.
Xie
Jian-Guo
JG
Lin
Connie B
CB
Kizoulis
Menas
M
Seiberg
Miri
M
Shapiro
Stanley
S
Conney
Allan H
AH
D000287:Administration, Topical; D000818:Animals; D017209:Apoptosis; D004249:DNA Damage; D005260:Female; D006358:Hot Temperature; D051379:Mice; D008812:Mice, Hairless; D009374:Neoplasms, Experimental; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology* / Q000517:prevention & control* / Q000662:veterinary; D041942:Soy Milk / Q000008:administration & dosage* / Q000494:pharmacology*; D013552:Swine; D014466:Ultraviolet Rays / Q000009:adverse effects