Palladium(II) diamine complex induces reduction of glutathione disulfide.
Reaction of [Pd(1R,2R-diaminocyclohexane)Cl(2)] with the oxidised form of the tripeptide glutathione ([gamma]-l-glutamyl-l-cysteinyl-glycine) in aqueous solution leads to reductive cleavage of the disulfide bond.
Munk
Vivienne P
VP
School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh, UK.
Sadler
Peter J
PJ
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D003959:Diamines / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry; D005978:Glutathione / Q000031:analogs & derivatives* / Q000737:chemistry*; D019803:Glutathione Disulfide / Q000737:chemistry*; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D003959:Diamines; D004220:Disulfides; D009842:Oligopeptides; D010165:Palladium; D005978:Glutathione; D019803:Glutathione Disulfide