Prevalence and clinical significance of solitary pulmonary sub-segmental microembolism.
BACKGROUND
Solitary pulmonary microembolism is rarely discussed as a distinct diagnostic entity. The purpose of this investigation was to determine the prevalence and clinical significance of embolism limited to subsegmental branches in a group of patients discharged from hospital on anticoagulants with a diagnosis of pulmonary embolism based on ventilation-perfusion imaging followed by selective angiography.


METHODS
Of 29 consecutive patients with classic signs of pulmonary embolism at angiography, we identified a subgroup of 5 patients with sub-segmental embolism, which was solitary in all cases.


RESULTS
Clinical presentation included chest pain (2/5), shortness of breath (2/5, or hypoxemia (1/5). Chest X-rays were normal (2/5), or showed pulmonary oedema (1/5) or atelectasis with (1/5), or without (1/5) pleural effusion. VQ imaging patterns included small subsegmental mismatch (1/5), one segment mismatch (1/5), single (1/5) or triple (2/5) match. The site and size of the microemboli found at angiography were incompatible with the location and severity of symptoms in 4/5 (80%) patients, and with location and extent of Chest X-ray findings and with VQ patterns in all patients. VQ abnormalities were either either disproportionably larger or were non congruent with the vascular territory compromised by the subsegmental embolus.


CONCLUSIONS
Sub-segmental pulmonary micro-emboli were always solitary, and not uncommon, comprising 17% of all patients with pulmonary embolism. The location and size of the emboli were inconsistent with clinical, Chest X-ray and scintigraphic findings, suggesting that isolated microemboli are a serendipitous finding, of no clinical significance.
Department of Nuclear Medicine, Maisonneuve-Rosemont Hospital Center, Montreal, QC, Canada. jlette@lette.com
Jean
J
Lette
Michel
M
Cerino
Marie-Claire
MC
Eybalin
André
A
Levasseur
D000328:Adult; D000368:Aged; D002170:Canada / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011859:Radiography; D011877:Radionuclide Imaging; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012720:Severity of Illness Index