Testosterone action on the Sertoli cell membrane: a KIR6.x channel related effect.
This review focuses on the fast testosterone actions on the cell membrane principally on the Sertoli cells, its predominant effect, i.e. an increase in [Ca+]i and the possibility of its actions being mediated by KIR (ATP) channels. The regulation of the K+ATP channels by phosphatidylinositol-4,5-bisphosphate depletion on the cell membrane as a result of the action of testosterone, its putative receptors, and the phospholipase C--phosphatidylinositol-4,5-bisphosphate pathway are discussed. The electrostatic interaction between anionic and cationic charges on the K+ATP modulation is also considered, in the light of testosterone's effect on phospholipase C--phosphatidylinositol-4,5-bisphosphate hydrolysis. Thus, the interaction of testosterone with its putative receptors, phospholipase C, phosphatidylinositol-4,5-bisphosphate, and K+ATP channels (or other KIR channels) in the membrane may be one of the mechanism of rapid testosterone's physiological action on some classes of cells.
Wassermann
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Departamento de Fisiologia-ICBS-UFRGS, Rua Sarmento Leite, 500, CEP 90050-170 Porto Alegre, RS, Brasil. gwass@ufrgs.br
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D018528:ATP-Binding Cassette Transporters; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects*; D006801:Humans; D054086:KATP Channels; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000502:physiology; D015221:Potassium Channels / Q000187:drug effects; D024661:Potassium Channels, Inwardly Rectifying / Q000187:drug effects*; D012708:Sertoli Cells / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*
D018528:ATP-Binding Cassette Transporters; D054086:KATP Channels; D010716:Phosphatidylinositols; D010743:Phospholipids; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; C092520:uK-ATP-1 potassium channel; D013739:Testosterone