Concise synthesis of isoquinoline via the Ugi and Heck reactions.
[reaction: see text] Two types of isoquinoline scaffolds were successfully constructed in a combinatorial format via the Ugi four-component reaction and the Pd-catalyzed intramolecular Heck reaction, starting from readily available starting materials.
Xiang
Zheng
Z
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing, 100871, China.
Luo
Tuoping
T
Lu
Kui
K
Cui
Jiayue
J
Shi
Xiaomeng
X
Fathi
Reza
R
Chen
Jiahua
J
Yang
Zhen
Z
D020650:Combinatorial Chemistry Techniques; D007546:Isoquinolines / Q000138:chemical synthesis*; D015394:Molecular Structure
D007546:Isoquinolines