Poor immune responses to influenza vaccination in infants.
Twenty-two and 37 infants and young children received two doses of influenza HA vaccine before the 2001-2002 influenza season and before the 2002-2003 season, respectively. Two or three serial specimens were obtained, before and 1 month after the first vaccination as well as 1 month after the second vaccination. Infants showed a significantly poor HI antibody rise and lymphocyte response compared with young children aged > or =12 months. Time kinetics of the lymphoproliferative responses to influenza antigen among young children varied whereas their activities in infants were typically negative before immunization and increased after vaccination. Infants responded poorly to HA influenza vaccine compared with young children.
Kumagai
Takuji
T
Pediatric Allergy and Infectious Diseases Society of Sapporo, Kumagai Pediatric Clinic, W-6, Momijidai, Atsubetsu-Ku, Sapporo 004-0013, Japan. tkuma@mb.infosnow.ne.jp
Nagai
Kazushige
K
Okui
Toyo
T
Tsutsumi
Hiroyuki
H
Nagata
Nobuo
N
Yano
Shoki
S
Nakayama
Tetsuo
T
Okuno
Yoshinobu
Y
Kamiya
Hitoshi
H
D000328:Adult; D000375:Aging / Q000276:immunology*; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D000918:Antibody Specificity; D002675:Child, Preschool; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology* / Q000502:physiology; D007115:Immunization Schedule; D007223:Infant; D007252:Influenza Vaccines / Q000276:immunology*; D007564:Japan; D007700:Kinetics; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology; D008297:Male
D000914:Antibodies, Viral; D007252:Influenza Vaccines