Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains.
When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.
Yang
Seung-Ju
SJ
Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea.
Lee
Jong Eun
JE
Lee
Kwan Ho
KH
Huh
Jae-Wan
JW
Choi
Soo Young
SY
Cho
Sung-Woo
SW
D000818:Animals; D017209:Apoptosis; D015153:Blotting, Western / Q000379:methods; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology*; D053454:Caspase 12; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D004347:Drug Interactions; D051100:Glial Cell Line-Derived Neurotrophic Factor; D020287:In Situ Nick-End Labeling / Q000379:methods; D008297:Male; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011753:Pyrones / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D019208:Brain-Derived Neurotrophic Factor; C495041:Gdnf protein, rat; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009942:Organometallic Compounds; D011753:Pyrones; C067527:aluminum maltolate; C506443:Casp12 protein, rat; C505410:Casp3 protein, rat; D053454:Caspase 12; D053148:Caspase 3; D020169:Caspases