Identification and functional analysis of the Drosophila gene loco.
In contrast to vertebrates, the fruit fly Drosophila melanogaster contains only a small number of regulator of G-protein signaling (RGS) domain genes. This article reviews current knowledge on these genes. Although the fruit fly is particularly amenable to genetic analysis and manipulation, not much is known about the functions and mechanisms of action. The best-studied RGS gene in Drosophila is loco, a member of the D/R12 subfamily. The four different protein isoforms all contain RGS, GoLoco, and RBD domains. This article describes the identification and functional analyses of loco in the Drosophila system and discusses some mechanistic models that may underlie loco function.
International Graduate School in Genetics and Functional Genomics, University of Cologne, Köln, Germany.
Sebastian
S
Granderath
Christian
C
Klämbt
D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D016254:Mutagenesis, Insertional; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D020710:RGS Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D029721:Drosophila Proteins; D019476:Insect Proteins; C119015:LOCO protein, Drosophila; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D020710:RGS Proteins