Comparison of protein carbonyl and total plasma thiol concentrations in patients with complete hydatidiform mole with those in healthy pregnant women.
BACKGROUND
Normal pregnant women are known to have increased oxidative stress and lipid peroxidation (which can be estimated by protein carbonyl concentration) but offsetting antioxidant protection (of which plasma thiols are an important component).


OBJECTIVE
This study set out to compare levels of these markers in normal pregnant women and patients with complete hydatidiform mole (CHM).


METHODS
Blood was taken from 41 healthy pregnant women and 39 patients with CHM attending a university hospital, and protein carbonyl and thiol levels determined spectrophotometrically on plasma. Statistical analysis of the results was performed using Student's t-test and Pearson's correlation.


RESULTS
Patients with CHM were found to have significantly higher levels of protein carbonyls and lower (but non-significant) levels of thiols.


CONCLUSIONS
The results may indicate oxidative stress as a feature of CHM.
Harma
Mehmet
M
Department of Obstetrics and Gynecology, University of Harran Medical School, Sanliurfa, Turkey. mehmetharma@superonline.com
Harma
Muge
M
Kocyigit
Abdurrahim
A
D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000175:diagnosis*; D015227:Lipid Peroxidation / Q000502:physiology*; D018384:Oxidative Stress; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood / Q000175:diagnosis*; D011336:Probability; D011379:Prognosis; D011506:Proteins / Q000378:metabolism*; D012016:Reference Values; D018570:Risk Assessment; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000097:blood* / Q000378:metabolism; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D011506:Proteins; D013438:Sulfhydryl Compounds