[Efficacy of combined paclitaxel and oxaliplatin therapy in patients with pretreated advanced non-small cell lung cancer].
OBJECTIVE
No chemotherapeutic regimen and agent are effective for patients with pretreated advanced non-small cell lung cancer (NSCLC). This study was designed to evaluate the efficacy and toxicity of the combination of paclitaxel and oxaliplatin in this subset of patients.


METHODS
Twenty-two patients who had been pretreated with platinum-based chemotherapy were enrolled into this study. All received paclitaxel (135 mg/m2, intravenous infusion over 3 hours on day 1) and oxaliplatin (130 mg/m2, intravenous infusion over 2 hours on day 1) every 28 days. The whole course of treatment consisted at least 2 cycles.


RESULTS
Of 22 patients, 5 achieved partial response with the overall response rate of 22.7%. Nearly all lesions shrank or remained stable after the first 2 cycles, except for those of 3 patients who showed progressive diseases. Median progression-free duration time was 4 months, and median survival time was 8 months. Commonly encountered toxicities included nausea and vomiting, myalgia/arthralgta, peripheral neuropathy, and myelosuppression.


CONCLUSIONS
Paclitaxel plus oxaliplatin combination was a safe and active regimen for patients with pretreated advanced NSCLC and deserves further evaluation.
Xie
Cong-Ying
CY
Department of Oncology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, PR China.
Wu
Shi-Xiu
SX
Zhang
Ping
P
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000556:secondary; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D017239:Paclitaxel / Q000008:administration & dosage; D016896:Treatment Outcome
D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D017239:Paclitaxel