The role of spontaneous general movement assessment in the neurological outcome of cerebral lesions in preterm infants.
OBJECTIVE
To study the relationship among the quality, type, and trajectory of general movements in preterm infants and neonatal cranial ultrasonography findings and neurological outcome.


METHODS
Forty preterm newborn infants, with gestational ages under 35 weeks, had their general movements recorded through video-tape during the preterm, term (37th - 42nd postconceptional weeks of age) and post-term (49th - 56th postconceptional weeks of age) periods, and were prospectively followed up to one-year conceptional age.


RESULTS
Our results showed that the quality of general movements, particularly in the post-term period (p = 0.009), were related with the presence of severe cerebral lesions in the neonatal cranial ultrasonography and the neurological outcome. While the presence of severe ultrasonography lesions was associated with an adverse neurological outcome (p = 0.01), the finding of normal general movements patterns was associated with a normal neurological outcome, with negative predictive values of 100%, for the preterm, and 80%, for both term and post-term periods.


CONCLUSIONS
When concurrently used, these evaluation methods may increase the specificity and sensitivity in detecting the group of preterm infants at high risk for neurological disturbances in long-term follow-up.
Garcia
Juliana M
JM
Department of Neurology and Pediatrics, Hospital das Clínicas, School of Medicine, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Gherpelli
José Luiz D
JL
Leone
Cléa R
CR
D001927:Brain Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009068:Movement / Q000502:physiology; D009460:Neurologic Examination / Q000379:methods; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D014743:Videotape Recording