The discrepancy between electrophoretic and nephelometric determinations of serum gamma-globulin level.
We studied the significance of discrepancies in correlation between serum gamma-globulin levels electrophoretically estimated and immunoglobulin levels nephelometrically determined. Discrepancies appeared in cases with IgA myeloma, macroglobulinemia, and rare types of dysgammaglobulinemia frequently overlooked in serum electrophoresis, IgD myeloma and gamma-heavy chain disease. It is suggested that comparison of the gamma-globulin levels by the different methods is a simple and useful method of detecting these dysgammaglobulinemias.
Central Clinical Laboratory, Nara Medical University Hospital, Kashihara, Japan.
Keiko
K
Morita
Yasuyuki
Y
Okamoto
D004406:Dysgammaglobulinemia / Q000175:diagnosis; D004588:Electrophoresis, Cellulose Acetate / Q000379:methods*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D009194:Myeloma Proteins; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D015203:Reproducibility of Results; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis; D005719:gamma-Globulins / Q000032:analysis*
D007136:Immunoglobulins; D009194:Myeloma Proteins; D005719:gamma-Globulins; C017551:myeloma immunoglobulins