MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma.
Manganese superoxide dismutase (SOD2) and myeloperoxidase (MPO) are polymorphic enzymes involved in reactive oxidative species metabolism. In this case-control study (830 non-small cell lung carcinoma (NSCLC) patients; 1119 controls) we evaluated whether the MPO -G463A polymorphism (associated with a novel estrogen receptor binding site) modifies the association between the SOD2 Ala16Val polymorphism and NSCLC risk differently by gender. For women carrying the MPO variant genotypes, the adjusted odds ratio of the SOD2 polymorphism (Val/Val vs. Ala/Ala) was 3.26 (95% CI, 1.55-6.83). No associations were found in men or in women carrying the MPO GG wildtype genotype.
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
Geoffrey
G
Liu
Wei
W
Zhou
Lisa I
LI
Wang
Sohee
S
Park
David P
DP
Miller
Li Lian
LL
Xu
John C
JC
Wain
Thomas J
TJ
Lynch
Li
L
Su
David C
DC
Christiani
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors; D013482:Superoxide Dismutase / Q000235:genetics*
D009195:Peroxidase; D013482:Superoxide Dismutase