Host response to a dam mutant of Salmonella enterica serovar enteritidis with a temperature-sensitive phenotype.
The temperature-sensitive dam mutant strain of Salmonella enterica serovar Enteritidis SD1 is highly attenuated and induces innate and protective immunity in mice. SD1 activates NF-kappaB and induces gamma interferon secretion. Early interaction of the SD1 mutant with intestinal epithelial cells was associated with ruffling of enterocytes. Invading bacteria were found inside Peyer's patches after inoculation.
Centro de Estudios Farmacológicos y Botánicoas (CEFYBO-CONICET), Buenos Aires, Argentina.
Mónica N
MN
Giacomodonato
Sebastián H
SH
Sarnacki
Roberto L
RL
Caccuri
Daniel O
DO
Sordelli
M Cristina
MC
Cerquetti
D000818:Animals; D006801:Humans; D007082:Ileum / Q000382:microbiology; D007113:Immunity, Innate; D007413:Intestinal Mucosa / Q000382:microbiology; D051379:Mice; D009154:Mutation; D010581:Peyer's Patches / Q000382:microbiology; D010641:Phenotype; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000382:microbiology; D012477:Salmonella enteritidis / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000235:genetics* / Q000378:metabolism; D013696:Temperature
C058693:Dam methyltransferase; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)