A limited role for DJ1 in Parkinson disease susceptibility.
An association study of four common polymorphisms in the DJ1 gene and Parkinson disease (PD) was conducted. PD probands were compared with their unaffected siblings matched by gender and closest age at study (416 vs 416) and with unrelated control subjects (691 vs 190). None of the four haplotype tagging single-nucleotide polymorphisms (SNPs) was associated with PD overall, but SNP1 (position 4,345 bp) and SNP3 (position 16,491 bp) were associated with PD in women (p = 0.03 and p = 0.002).
Department of Neurology, Mayo Clinic Rochester, MN 55905, USA. dmaraganore@mayo.edu
D M
DM
Maraganore
K
K
Wilkes
T G
TG
Lesnick
K J
KJ
Strain
M
M
de Andrade
W A
WA
Rocca
J H
JH
Bower
J E
JE
Ahlskog
S
S
Lincoln
M J
MJ
Farrer
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006114:Great Lakes Region / Q000453:epidemiology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D000071617:Protein Deglycase DJ-1; D011944:Receptors, Androgen / Q000378:metabolism; D012727:Sex Characteristics; D035781:Siblings
D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; D011944:Receptors, Androgen; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1