An immunogenic process leading to cancer in the context of immunodeficiency.
Colorectal MSI tumors are associated with an increased immune response. On the other hand, immunodeficient patients are more prone to lymphomas with the MSI phenotype. These facts are of wide interest in understanding the complex link between immunity and cancer, particularly of the MSI phenotype. Specific attention to the host immune system should thus be considered in the treatment of patients with MSI tumors.
INSERM U434, Paris, France. richard.hamelin@cephb.fr
Richard
R
Hamelin
Claire
C
Borie
Martine
M
Raphaël
Alex
A
Duval
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000235:genetics / Q000276:immunology; D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology; D002277:Carcinoma / Q000235:genetics / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology*; D043171:Chromosomal Instability / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D018895:Microsatellite Repeats / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*
D000951:Antigens, Neoplasm