Effect of a silicone intraocular lens with a sharp posterior optic edge on posterior capsule opacification.
OBJECTIVE
To compare the inhibiting effect on posterior capsule opacification (PCO) of a silicone intraocular lens (IOL) with a sharp posterior optic edge (ClariFlex OptiEdge, Advanced Medical Optics) and a silicone IOL with a round optic edge (PhacoFlex SI-40, Advanced Medical Optics).


METHODS
Department of Ophthalmology, University of Vienna, Vienna, Austria.


METHODS
This prospective randomized patient- and examiner-masked study comprised 104 eyes of 52 patients with bilateral age-related cataract. All patients had cataract surgery in both eyes and received a sharp-edged IOL in 1 eye and a round-edged IOL in the other eye. Postoperative examinations were at 1 week, 1 and 6 months, and 1 year. Digital slitlamp and retroillumination images were taken of each eye. The amount of PCO was assessed subjectively at the slitlamp and objectively using Automated Quantification of After-Cataract (AQUA) automated-image analysis software.


RESULTS
The sharp-edged IOL group had significantly less regeneratory and fibrotic PCO 1 month, 6 months, and 1 year after surgery. The mean AQUA PCO score (scale 0 to 10) was 0.71 in the sharp-edged IOL group and 1.40 in the round-edged IOL group (P<.001). The sharp-edged IOL group had less peripheral fibrotic PCO. There was no significant difference between the 2 IOL groups in patient reports of edge glare.


CONCLUSIONS
The sharp-edged design of the ClariFlex OptiEdge silicone IOL led to significantly less PCO than the round-edged PhacoFlex SI-40 IOL 1 year postoperatively.
Department of Ophthalmology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Wolf
W
Buehl
Rupert
R
Menapace
Stefan
S
Sacu
Katharina
K
Kriechbaum
Christina
C
Koeppl
Matthias
M
Wirtitsch
Michael
M
Georgopoulos
Oliver
O
Findl
D000368:Aged; D019923:Capsulorhexis; D002386:Cataract / Q000517:prevention & control*; D004311:Double-Blind Method; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D018918:Phacoemulsification; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011474:Prosthesis Design; D012826:Silicone Elastomers; D016896:Treatment Outcome; D014792:Visual Acuity
D012826:Silicone Elastomers