Estimation of the end of ejection in aortic stenosis: an unreported source of error in the invasive assessment of severity.
BACKGROUND
All indices of aortic stenosis (AS) rely on measurements of mean transvalvular pressure gradient (DeltaP) and flow rate. Because the gradient is reversed during late ejection, the late systolic left ventricular (LV)-aortic pressure crossover may be an erroneous landmark of end-ejection. The aortic incisura should be a better reference to calculate indices of AS invasively.


RESULTS
The accuracy of the pressure crossover and the incisura to define end-ejection was assessed in a chronic AS experimental model (9 dogs) with the use of an implantable flowmeter and Doppler echocardiography as reference. In 288 hemodynamic recordings analyzed (aortic valve area [AVA]: 0.74+/-0.46 cm2), ejection ended 37+/-29 ms after the pressure crossover but almost simultaneously with the incisura (2+/-17 ms). Pressure crossover error accounted for significant errors in the measurement of DeltaP (95% limits of agreement, +0 to +7 mm Hg) and AVA (-0.1 to +0.2 cm2). These errors were reduced to less than half with the use of the incisura to define end-ejection. Additionally, the agreement with Doppler-derived AS indices was best with use of the incisura. Pressure crossover error was maximal in situations of higher output, moderate orifice narrowing, higher arterial compliance, and lower vascular resistance. In 32 consecutive patients undergoing cardiac catheterization for AS, the pressure crossover induced a clinically important overestimation of the DeltaP from +22 to +50%. Errors in AVA estimation were considerably smaller (-2% to +6%) because of simultaneous and offsetting errors in the measurements of DeltaP and flow.


CONCLUSIONS
The aortic incisura and not the second pressure crossover should be used to obtain invasive indices of AS.
Bermejo
Javier
J
Laboratory of Echocardiography, Department of Cardiology, Hospital General Universitario Gregorio Marañón, Dr Esquerdo 46, 28007 Madrid, Spain. javbermejo@jet.es
Rojo-Alvarez
José Luis
JL
Antoranz
J Carlos
JC
Abel
Monica
M
Burwash
Ian G
IG
Yotti
Raquel
R
Moreno
Mar
M
García-Fernández
Miguel A
MA
Lehmann
Kenneth G
KG
Otto
Catherine M
CM
D000465:Algorithms; D000818:Animals; D001011:Aorta; D001021:Aortic Valve / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D006328:Cardiac Catheterization; D002302:Cardiac Output; D003951:Diagnostic Errors; D004280:Dobutamine; D004285:Dogs; D015150:Echocardiography, Doppler; D006352:Heart Ventricles; D006801:Humans; D011312:Pressure; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted; D013318:Stroke Volume
D004280:Dobutamine