Block of Thalamic T-Type Ca(2+) Channels by Ethosuximide Is Not the Whole Story.
On the basis of more than a decade of studies on the cellular effects of ethosuximide, currently, the most prudent view is that together with a block of the low threshold, T-type Ca(2)(+) current, a reduction both of the noninactivating Na(+) current, and the Ca(2)(+)-activated K(+) current in thalamic and cortical neurones contribute to the overall therapeutic action of this antiabsence medicine.
School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom, and UMR CNR5 7102 Neurobiologie des Processus Adaptatifs, Université Pierre et Marie Curie, Paris, France.
Vincenzo
V
Crunelli
Nathalie
N
Leresche