[Bronchial changes in untreated asthma].
Persistent asthma is associated to airway remodeling, characterized by structural changes of the bronchi, poorly responsive to therapies. Remodeling may strongly contribute to the residual airway obstruction observed in asthmatic patients, both children and adults, and to the loss of reversibility of this obstruction. Remodeling has been demonstrated in paediatric asthma and is not limited to longstanding severe asthma. Numerous arguments indicate that this process begins early in the development of asthma. Some studies argue for a possible prevention - or limitation - of this process by an early treatment.
Centre hospitalier intercommunal, 40, avenue de Verdun, 94000 Créteil, France. christophe.delacourt@chicreteil.fr <christophe.delacourt@chicreteil.fr>
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D000402:Airway Obstruction / Q000517:prevention & control; D001249:Asthma / Q000473:pathology* / Q000503:physiopathology; D001980:Bronchi / Q000473:pathology*; D006801:Humans