Polymorphism of Prodynorphin promoter is associated with schizophrenia in Chinese population.
OBJECTIVE
To investigate the correlation between single nucleotide polymorphisms (SNPs) of functional candidate gene Prodynorphin (PDYN) and schizophrenia.


METHODS
SNPs in the promoter and exon regions of PDYN were screened and genotyped for association study in a cohort of Chinese Han schizophrenia cases and controls.


RESULTS
Two SNPs PDYN-1576C>T and PDYN-946C>G were identified in the promoter region but PDYN-946C>G showed significant differences of allele distribution (x2=6.15, P=0.013) and genotype distribution (x2=6.87, P=0.032) between schizophrenic and control subjects.


CONCLUSIONS
PDYN-946C>G polymorphism demonstrated an association with population susceptibility to schizophrenia.
Zhang
Chang-Shun
CS
Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China.
Tan
Zheng
Z
Lu
Lan
L
Wu
Sheng-Nan
SN
He
Ying
Y
Gu
Niu-Fan
NF
Feng
Guo-Yin
GY
He
Lin
L
D000328:Adult; D044466:Asian People; D004745:Enkephalins / Q000235:genetics*; D005091:Exons; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011498:Protein Precursors / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D004745:Enkephalins; D011498:Protein Precursors; C033660:preproenkephalin