A remarkably efficient coupling of acid chlorides with alkynes in water.
[reaction: see text] A highly effective direct coupling of acid chloride with terminal alkynes catalyzed by PdCl(2)(PPh(3))(2)/CuI together with a catalytic amount of sodium lauryl sulfate as the surfactant and K(2)CO(3) as the base provided ynones in high yields in water.
Chen
Liang
L
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
Li
Chao-Jun
CJ