[Analysis of anti-microbial resistance of Escherichia coli that caused infection in urogenital system].
OBJECTIVE
To study the anti-microbial resistance of Escherichia coli (E.coli) that caused infection in urogenital system.


METHODS
Anti-microbial susceptibility tests for 148 strains of E.coli were conducted by disc diffusion technique.


RESULTS
In 28 commonly used antibiotics, the resistance rates of E. coli to beta-lactam and quinolones were high (73.6%-86.4%). High resistance rates to the first- and the second-generation cephalosporin (cefradime, cephazolin and cefaclor) were also observed (44%). Resistance rate to ceftazidime is the lowest (10.1%) in the third-generation cephalosporin. The resistance rates of E. coli to piperacillin, pefoperazone and ampicillin were 84.5%, 44.6% and 83.0% respectively. Combined antibiotic and beta-lactam inhibitor gave lower resistance rates than antibiotic alone (piperacillin/tazobactam, cefoporazone/sulbactam and ampicillin/sulbactam were 4.1%, 10.8% and 52.0% respectively, P<0.01). Of 148 E. coli isolates, 38 strains were capable of yielding extended-spectrum beta-lactamases (ESBLs) (25.7%), 110 strains were not able to produce ESBLs (74.3%) and the resistance rates of isolates with ESBLs to 28 antibiotics were significantly lower than those of isolates without ESBLs.


CONCLUSIONS
Antibiotic/beta-lactam inhibitor and nitrofurantoin are effective for urogenital infections caused by E. coli.
Cui
Wei-li
WL
Guangzhou Army Command Hospital, Guangzhou 510010, China.
Xu
De-xing
DX
Li
Wen-ling
WL
Wang
Lu-xia
LX
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000382:microbiology*; D018440:beta-Lactam Resistance; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D015363:Quinolones; D047090:beta-Lactams