Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats.
The electroencephalographic (EEG) effects of two choline pivaloyl esters, [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium iodide (1) and [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium 2,2-dimethylpropionate (2), were evaluated in scopolamine-treated or nucleus basalis magnocellularis (NBM) lesioned rats. In scopolamine-treated animals, Compounds 1 and 2 prevented or reduced EEG effects, such as increased amplitude of total spectra and high-voltage spindle (HVS) activity as well. Furthermore, choline esters showed a noticeable effectiveness in reversing the EEG changes produced in rats by AMPA-induced lesion of NBM. Indeed, Compounds 1 and 2 were able to induce EEG desynchronisation, a significant decrease in the total EEG power (0.25-16 Hz) and in the lower frequency delta and theta bands (0.25-3 and 3-6 Hz, respectively). The EEG effects produced by Compounds 1 and 2 were well comparable with that evoked by Tacrine, used as a reference compound. The results of the present work allow us to put forward the hypothesis that the EEG effects observed are most likely mediated through the stimulation of the cholinergic neurotransmission ensuing from enhanced cerebral levels of acetylcholine (ACh) consequent upon acetylcholinesterase (AChE) inhibition by choline pivaloyl esters.
Department of Pharmacobiological Sciences, University of Catanzaro, "Magna Graecia", Complesso "Ninì Barbieri", I-88021 Roccelletta di Borgia (CZ), Italy. rispoli@unicz.it
Vincenzo
V
Rispoli
Domenicantonio
D
Rotiroti
Vincenzo
V
Carelli
Felice
F
Liberatore
Luigi
L
Scipione
Rosario
R
Marra
Silvano
S
Tortorella
Barbara
B
Di Rienzo
D000818:Animals; D020532:Basal Nucleus of Meynert / Q000033:anatomy & histology / Q000187:drug effects*; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004952:Esters / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D010296:Parietal Lobe / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000494:pharmacology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
C484885:(2-(2,2-dimethylpropionyloxy)ethyl)trimethylammonium; D004952:Esters; D010276:Parasympatholytics; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D012601:Scopolamine; D002795:Choline O-Acetyltransferase; D002794:Choline