Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients.
MICA and MICB, as members of the major histocompatibility complex (MHC) class I-chain-related genes (MIC), encode stress-inducible glycoproteins that act as activating ligands for NKG2D and gammadelta T-cell receptor-bearing cells. We here describe the identification of eight novel MICB variants, including a null allele, which were identified in peripheral blood leukocytes of gastric MALT lymphoma patients. Only two of the novel alleles are characterized by point mutations, whereas the other variants display a recombination of known exonic MICB sequences that may be best explained by intragenic conversions. The novel MICB null allele is characterized by a Cytosin (C) deletion in a stretch of four Cs beginning from nucleotide 135 of exon 2 that leads to a premature stop codon (TGA) at codon 66.
Department of Transfusion Medicine, Hannover Medical School, Hannover, Germany.
M
M
Schroeder
H-A
HA
Elsner
T D
TD
Kim
R
R
Blasczyk
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D017353:Gene Deletion; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D017354:Point Mutation; D013274:Stomach Neoplasms / Q000235:genetics* / Q000276:immunology / Q000382:microbiology
D015395:Histocompatibility Antigens Class I; C098080:MICB antigen