[The specificity of expression of molecular biological markers in tumors of the mammary gland].
Data are described on a retrospective immunohistochemical study of the Ki-67, PCNA, Bcl-2, BAX, BclX and VEGF expression in tumors of two groups of patients with breast cancer (BC) and with the favorable and unfavorable clinical courses. A reliably high level of VEGF expression was detected in tumors of patients with an early BC relapse. Apart from VEGF, higher levels of the Ki-67 and PCNA expression were registered in tumors of the discussed patient's category. It can be suggested that the expression parameters of VEGF, Ki-67 and PCNA in the primary tumor can be made use of in evaluating the BD prognostications or describing the features of high-risk groups with a high probability of early disease relapses.
N E
NE
Kushlinskiĭ
M B
MB
Orinovskiĭ
L E
LE
Gurevich
I A
IA
Kazantseva
Sh Zh
ShZh
Talaeva
V D
VD
Ermilova
E K
EK
Dvorova
A S
AS
Ozherel'ev
V P
VP
Letiagin
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008875:Middle Aged; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D042442:Vascular Endothelial Growth Factors / Q000096:biosynthesis; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein
C494826:BAX protein, human; C494811:BCL2L1 protein, human; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D042442:Vascular Endothelial Growth Factors; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein