Combined quinacrine and chlorpromazine therapy in fatal familial insomnia.
Prion diseases are invariably fatal. Recently, quinacrine and chlorpromazine have been suggested as immediate candidates for the treatment of Creutzfeldt-Jakob disease and other prion diseases. The objective of this paper was to report on 2 fatal familial insomnia patients whose overall condition worsened despite quinacrine and chlorpromazine treatment.
Service of Neurology, Móstoles General Hospital, Móstoles, Madrid, Spain. jbenitol@meditex.es
Julián
J
Benito-León
D000328:Adult; D002746:Chlorpromazine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D034062:Insomnia, Fatal Familial / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011796:Quinacrine / Q000627:therapeutic use*; D012189:Retrospective Studies; D017211:Treatment Failure
D004791:Enzyme Inhibitors; C054028:chlorproethazine; D011796:Quinacrine; D002746:Chlorpromazine