Design of an inversion center between two helical segments.
A new strategy is proposed to control the relative orientation of two folded helical oligomers in such a way that they diverge from an aromatic linker and have opposite helical handedness. Mutual steric exclusion between the two helices results from the fact that they cannot be at the same time folded and on the same side of the linker. The concept is validated using the helical conformations of oligoamides of 8-amino-2-quinolinecarboxylic acid, but it should be applicable to many families of oligomers and leads to the first designed meso-helices.
Maurizot
Victor
V
Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France.
Dolain
Christel
C
Leydet
Yoann
Y
Léger
Jean-Michel
JM
Guionneau
Philippe
P
Huc
Ivan
I
D040761:Biomimetic Materials / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009757:Nylons / Q000737:chemistry*; D017433:Protein Structure, Secondary; D011804:Quinolines / Q000737:chemistry*; D012996:Solutions
D002264:Carboxylic Acids; D009757:Nylons; D011804:Quinolines; D012996:Solutions