Description of a novel HLA-DRB1 allele found in a candidate for bone marrow transplantation.
We report the identification of a new DRB1* allele in a Spanish Caucasoid family during a search for a histocompatible bone marrow donor. This novel allele, designated as DRB1*1145, differs from DRB1*1123 in one nucleotide at position 199 in exon 2 (A replacing T), leading to one amino acid change from phenylalanine (Phe) to isoleucine (Ile) at codon 67. The propositus's father had identical class II alleles but showed a minor mismatch at locus B (B*4403 by B*4402) and a C-locus mismatch (Cw*1502 by Cw*0501). We discuss the criteria of selecting a non-related bone marrow donor with a minor mismatch on the DRB1* allele or the related father having a minor mismatch at B locus and a C-locus mismatch.
Mas
V
V
Servei d' Immunologia, Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.
Arias
M T
MT
Fabregat
V
V
Nomdedeu
B
B
Serrapagès
C
C
Vives
J
J
Martorell
J
J
Carreras
E
E
Ercilla
M G
MG
D000483:Alleles; D000595:Amino Acid Sequence; D016026:Bone Marrow Transplantation; D005190:Family; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C497143:HLA-DRB1*11:45 antigen