Immunity and vaccine control of Echinococcus granulosus infection in animal intermediate hosts.
Much progress has been made with characterisation of the EG95 vaccine which can be used to prevent hydatid infection in animal intermediate hosts of Echinococcus granulosus. The vaccine comprises a single recombinant oncosphere antigen and the adjuvant Quil A. It induces complement-fixing antibodies that kill the invading oncosphere early in an infection. In the majority of vaccinated animals, no hydatid cysts occur following a challenge infection. However, a small number of viable cysts may occur in some vaccinated animals. The vaccine has proved effective in vaccine trials carried out in sheep in New Zealand, Australia, Argentina, Chile and China as well as in goats and cattle. Investigations of the genetic diversity of the gene encoding EG95 have identified no unequivocal variation within the G1 strain parasites; however DNA sequence diversity within the EG95 family of genes has been found in G6/G7 parasites. GMP production scale-up of the vaccine has been undertaken in New Zealand and China and it is expected that the vaccine will be become available through these sources for implementation as part of hydatid control programs worldwide.
Veterinary Clinical Centre, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia. marshall@unimelb.edu.au
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D000818:Animals; D000940:Antigenic Variation; D000947:Antigens, Helminth / Q000235:genetics / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D002986:Clinical Trials as Topic / Q000662:veterinary; D004443:Echinococcosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D004446:Echinococcus / Q000235:genetics / Q000276:immunology*; D014943:Global Health; D015511:Goat Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D006041:Goats; D015801:Helminth Proteins / Q000235:genetics / Q000276:immunology; D007115:Immunization Schedule; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary*; D014612:Vaccines / Q000276:immunology*
D000947:Antigens, Helminth; C446034:EG95 protein, Echinococcus granulosus; D015801:Helminth Proteins; D014612:Vaccines