No association of TAP2 polymorphisms in Korean patients with schizophrenia.
OBJECTIVE
Polymorphisms of transporters associated with antigen-processing (TAP) genes might influence the susceptibility to schizophrenia by altering the antigen-processing pathway. The aim of this study was to verify the relationship between schizophrenia and the polymorphisms of TAP2 genes.


METHODS
Two hundred and fifty-seven Korean patients diagnosed with schizophrenia according to DSM-IV and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction single-strand conformation polymorphism.


RESULTS
Distribution of the alleles and genotypes in patients with schizophrenia was not significantly different from those of controls.


CONCLUSIONS
This study did not show the association of the TAP2 gene with schizophrenia in the Korean population.
Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Tae-Youn
TY
Jun
Kyoung-Uk
KU
Lee
Chi-Un
CU
Pae
Jeong-Ho
JH
Chae
Won-Myong
WM
Bahk
Kwang-Soo
KS
Kim
Tae-Yul
TY
Lew
D044466:Asian People / Q000235:genetics; D003062:Codon / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D011506:Proteins / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*
D003062:Codon; D011506:Proteins