QTLs for height: results of a full genome scan in Dutch sibling pairs.
Height is a highly heritable, complex trait. At present, the genes responsible for the variation in height have not yet been identified. This paper summarizes the results of previous linkage studies and presents results of an additional linkage analysis. Using data from the Netherlands Twin Register, a sib-pair-based linkage analysis for adult height was conducted. For 513 sib-pairs from 174 families complete genome scans and adult height were available. The strongest evidence for linkage was found for a region on chromosome 6, near markers D6S1053 and D6S1031 (LOD = 2.32). This replicated previous findings in other data sets. LOD scores ranging from 1.53 to 2.04 were found for regions on chromosomes 1, 5, 8, 10, and 18. The region on chromosome 18 (LOD = 1.83) also corresponded with the results of previous studies. Several chromosomal regions are now implied in the variance in height, but further study is needed to draw definite conclusions with regard to the significance of these regions for adult height.
Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, Amsterdam 1081 BT, The Netherlands. ahm.willemsen@psy.vu.nl
Gonneke
G
Willemsen
Dorret I
DI
Boomsma
A Leo
AL
Beem
Jacqueline M
JM
Vink
P Eline
PE
Slagboom
Danielle
D
Posthuma
D001827:Body Height / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D009426:Netherlands; D040641:Quantitative Trait Loci / Q000235:genetics*; D035781:Siblings; D044465:White People