Hydrofluoroalkane-beclomethasone versus chlorofluorocarbon-beclomethasone delivery in neonatal models.
Dose delivery of hydrofluoroalkane-beclomethasone and chlorofluorocarbon-beclomethasone was compared during in vitro neonatal simulations: mechanical ventilation with 40% and 100% relative humidity + Neonatal Chamber-Ventilator System/endotracheal tube; manual ventilation + Neonatal Chamber/endotracheal tube; "spontaneous breathing" + Neonatal Chamber/face mask without/with manual assistance. The delivery of hydrofluoroalkane-beclomethasone was significantly greater in each simulation.
The Floating Hospital for Children, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA. ccole@bidmc.harvard.edu
C H
CH
Cole
J P
JP
Mitchell
M P
MP
Foley
M W
MW
Nagel
D000280:Administration, Inhalation; D000335:Aerosol Propellants / Q000008:administration & dosage*; D000336:Aerosols; D001507:Beclomethasone / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D017402:Chlorofluorocarbons / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000008:administration & dosage*; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D008397:Masks; D009330:Nebulizers and Vaporizers; D012121:Respiration, Artificial; D005466:Fluorocarbons
D000335:Aerosol Propellants; D000336:Aerosols; D001507:Beclomethasone; D017402:Chlorofluorocarbons; D005938:Glucocorticoids; D006845:Hydrocarbons, Fluorinated; C094049:apaflurane; D005466:Fluorocarbons