Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT-08) in rodents.
A pharmacological assessment of the standardized extract (BNT-08) of Pfaffia glomerata roots was performed in young mice submitted to acute treatment with several doses (i.p.), in young and old mice submitted to chronic oral treatment for 150 days or with water (control groups) and in old mice at a dose of 100 mg/kg of extract. Acute tests involved an initial screening, spontaneous movements, rota-rod, barbiturate sleeping time and passive avoidance were carried out. The chronic test involved mortality assessment, body weight and learning and memory in a T-maze left/right discrimination test and in the passive avoidance model. Of the acute tests only the sleeping time test showed relevant differences between the groups. With the chronic treatment, a relevant decrease of the number of sessions necessary for learning in the group of old mice treated with the extract was evident. A partial reversal of the memory de fi cit induced by age in the old mice treated with the extract was found in the passive avoidance test. The results suggest that the standardized extract from Pfaffia glomerata roots promoted an increase in both learning and memory of old mice treated in the chronic test.
Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringá - Av. Colombo 5790, bloco K80, 87020-900, Maringá, Paraná, Brazil. lmarques@teracom.com.br
Luís Carlos
LC
Marques
Suzana Maria Pereira
SM
Galvão
Eduardo
E
Espínola
Rosângela Fernandes
RF
Dias
Rita
R
Mattei
Maria Gabriela Menezes
MG
Oliveira
Elisaldo Luiz
EL
De Araújo Carlini
D000284:Administration, Oral; D027703:Amaranthaceae; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts