The influence of polarizing GIK mixture on the indicators of myocardial necrosis.
For the estimation of the role of GIK in diminishing post-infarction necrosis, the influence of GIK mixture on indicative enzymes (such as: CPK, CK-MB, ASPAT and ALAT) was checked. In a group of patients treated with GIK the increase of CPK and CK-MB activity after 24 hours was less pronounced, comparing to placebo group and differences between groups were at the borderline of statistical significance. Other parameters in both groups did not change in statistically significant way. A noted profitable change in CPK and CK-MB activity speaks in favour of GIK mixture and it is role in diminishing myocardial necrosis.
Department of Internal Medicine, Medical University of Lublin, Lublin, Poland.
Ewa
E
Rymarz
Jerzy
J
Mosiewicz
Janusz
J
Hanzlik
D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology*; D011188:Potassium / Q000494:pharmacology*; D016896:Treatment Outcome
D007328:Insulin; D007527:Isoenzymes; C030396:glucose-insulin-potassium cardioplegic solution; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D005947:Glucose; D011188:Potassium