Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema.
The extracts obtained from 14 plants of the Mexican medicinal flora were assessed for anti-inflammatory activity by carrageenan-induced rat paw edema model. The i.p. administration of the extracts at a dose of 400 mg/kg produced a high reduction of edema with 70% of the plant extracts. Oenothera rosea methanol extract, Sphaeralcea angustifolia chloroform extract, Acaciafarnesiana, Larrea tridentata and Rubus coriifolius methanol extracts as well as the aqueous extract of Chamaedora tepejilote were demonstrated to be particularly active against the induced hind-paw edema. Moderate inhibition of edema formation was also demonstrated with the methanol extracts of Astianthus viminalis, Brickellia paniculata, C. tepejilote and Justicia spicigera.
Unidad de Investigación Medica en Farmacologia de Productos Naturales, Centro Medico Nacional Siglo XXI, IMSS., Av Cuauhtémoc 330, Col. Doctores, México DF, Mexico. meck7707@prodigy.net.mx
M
M
Meckes
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David-Rivera
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V
Nava-Aguilar
A
A
Jimenez
D000045:Acacia; D000818:Animals; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D032442:Larrea; D008297:Male; D008519:Medicine, Traditional; D008800:Mexico; D031664:Oenothera; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013098:Xylariales
D010936:Plant Extracts; D002351:Carrageenan