Parameters of the attenuated schistosome vaccine evaluated in the olive baboon.
Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.
Institute of Primate Research, Karen, Nairobi, Kenya.
Thomas M
TM
Kariuki
Idle O
IO
Farah
Dorcas S
DS
Yole
Jason M
JM
Mwenda
Govert J
GJ
Van Dam
André M
AM
Deelder
R Alan
RA
Wilson
Patricia S
PS
Coulson
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D006801:Humans; D010215:Papio; D010270:Parasite Egg Count; D012547:Schistosoma / Q000276:immunology* / Q000302:isolation & purification; D012552:Schistosomiasis / Q000276:immunology / Q000469:parasitology* / Q000517:prevention & control*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000276:immunology*
D000909:Antibodies, Helminth; D014613:Vaccines, Attenuated