Complementary peptide epitopes and anti-idiotypic antibodies in autoimmunity.
Application of complementary B and T cell epitopes in inducing anti-idiotypic and anti-clonotypic antibodies capable of regulating or suppressing the autoimmune responses in experimental autoimmune myasthenia gravis (EAMG), allergic neuritis (EAN) and allergic encephalomyelitis (EAE) has been the stimulus of many research efforts. Studies on the idiotypic/anti-idiotypic network of anti-La/SSB positive sera from patients with Sjogren's Syndrome (SS) and Systemic Lupus Erythematosus (SLE) and on animals immunized with the complementary epitopes are presented.
Sakarellos-Daitsiotis
Maria
M
Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
Cung
Manh-Thong
MT
Sakarellos
Constantinos
C
El Hilali
Zouhair
Z
Kosmopoulou
Aggeliki
A
Voitharou
Chryssa
C
D000595:Amino Acid Sequence; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009157:Myasthenia Gravis / Q000276:immunology; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology; D010455:Peptides / Q000737:chemistry / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000276:immunology; D021241:Spectrometry, Mass, Electrospray Ionization; D020349:Surface Plasmon Resonance; D013601:T-Lymphocytes / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D010455:Peptides