[Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines].
OBJECTIVE
To observe the synergistic effect of Qilian decoction (QLD) with corresponding hypoglycemic agents on insulin sensitivity in patients with diabetes mellitus type 2 and its influence on related inflammatory cytokines.


METHODS
Sixty-two patients with diabetes mellitus type 2 were selected and randomly divided into two groups, they were treated with hypoglycemic agent in routine, and QLD was given orally, one dose taken in twice a day. Parameters as fasting blood glucose, insulin, peptide C, tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), interleukin 6 (IL-6) were measured before and after treatment, and insulin sensitive index (ISI) was also calculated.


RESULTS
The level of fasting blood glucose lowered after treatment in both groups (P<0.01); levels of fasting insulin, peptide C, ISI, TNF-alpha, IL-6 and CRP significantly lowered after treatment (P<0.05 or P<0.01), and the effect was better than that in the control group (P<0.05 or P<0.01).


CONCLUSIONS
QLD could improve the insulin resistance and lower the levels of related inflammatory cytokines.
TCM Department, People's Hospital of Putuo District of Shanghai, Shanghai 200060.
Shu-rong
SR
Gao
Jian-hong
JH
Bu
Liang-zheng
LZ
Zhu
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood; D008517:Phytotherapy; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D007328:Insulin; D015850:Interleukin-6; D010455:Peptides; D014409:Tumor Necrosis Factor-alpha; C050632:polypeptide C; D002097:C-Reactive Protein