Severity of focal microgyria and associated rapid auditory processing deficits.
Data from rodent models of induced microgyria suggest that bilateral damage leads to more severe rapid auditory processing deficits than unilateral damage. It is unclear whether this reflects the degree, or bilateral/unilateral nature, of damage. The current study evaluates the effects of microgyric severity by assessing rats with single- vs double-pair bilateral focal microgyric lesions, using auditory discrimination and MGN measures. Behavioral data show a significant auditory processing deficit on rapid processing tasks for microgyric as compared to control subjects, and also reveal more severe deficits for double- than for single-pair bilateral microgyrics. Greater disruptions are also seen in the MGN of double-pair compared to single-pair bilateral microgyric subjects.
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, 3107 Horse Barn Hill Rd. U-4154, Storrs, CT 06269-4154, USA.
Ann M
AM
Peiffer
Melissa M
MM
McClure
Steven W
SW
Threlkeld
Glenn D
GD
Rosen
R Holly
RH
Fitch
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001308:Auditory Perceptual Disorders / Q000503:physiopathology*; D001522:Behavior, Animal; D001921:Brain; D001927:Brain Diseases / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000293:injuries / Q000473:pathology* / Q000503:physiopathology*; D016009:Chi-Square Distribution; D003216:Conditioning, Operant; D007839:Functional Laterality / Q000502:physiology; D005829:Geniculate Bodies / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000502:physiology