[Neurological criteria for drug-resistance in epilepsy].
Drug-resistance is widely considered as a prerequisite for any surgical treatment in epilepsy. It is however noteworthy that an international consensus regarding the definition of this pharmacological concept, or, at least, detailing the criteria required for the diagnosis, is lacking. Based on a systematic review of the literature, we discuss the proposed definitions in expert's position papers or used in controlled or multicentric studies. A check-list for the diagnosis of drug-resistant epilepsy is proposed.
EFSN, Département de Neurologie, CHU Grenoble, BP 217X-38043 Grenoble cedex, France. LVercueil@chu-grenoble.fr
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D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D009462:Neurology; D012008:Recurrence
D000927:Anticonvulsants