Interleukin-2 and its soluble receptor in selected drug-induced cutaneous reactions.
Plasma concentrations of interleukin-2 (IL-2) and its soluble receptor (sIL-2R) were examined in 126 patients with drug-induced skin reactions: maculopapular eruptions (ME), erythema multiforme (EM), erythema multiforme coexisting with erythema nodosum (EMN), drug-induced urticaria (DU), hyperergic vasculitis (HV), Stevens-Johnsson syndrome and toxic epidermal necrolysis (SJS/TEN). The activity of both proteins were measured using immunoenzymatic ELISA method: a) in the acute stage of disease, before treatment was administered, and b) after clearing of skin symptoms, after treatment. In the acute stage of disease highly elevated mean concentrations of IL-2 and sIL-2R in all 6 groups of patients were found (p<0.001) in comparison with the control. After clearing of skin lesions IL-2 mean concentrations were lowered to the level not different significantly from the control (p>0.05), but slL-2R mean plasma concentrations, despite the deep decrease, were still highly significantly elevated in comparison with control values (p<0.001).
Chair and Department of Dermatology, Medical University of Lublin.
Grazyna
G
Chodorowska
Dorota
D
Czelej
Marta
M
Niewiedzioł
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D003875:Drug Eruptions / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay; D004817:Epidermis / Q000276:immunology*; D004892:Erythema Multiforme / Q000139:chemically induced; D004893:Erythema Nodosum / Q000139:chemically induced; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010267:Parapsoriasis / Q000139:chemically induced; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012867:Skin / Q000187:drug effects*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000209:etiology; D013997:Time Factors; D014581:Urticaria / Q000139:chemically induced; D014657:Vasculitis / Q000139:chemically induced
D007376:Interleukin-2; D015375:Receptors, Interleukin-2