Breast cancer incidence and use of antihypertensive medication in women.
OBJECTIVE
Breast cancer is the most common cancer in women worldwide. We attempted to investigate the association between the risk of breast cancer and use of captopril and other antihypertensive medication.


METHODS
We performed a cohort study with a nested case-control analysis using the General Practitioner Research Database (GPRD) from the UK. We obtained adjusted estimates by fitting logistic regression models.


RESULTS
The incidence rate of breast cancer in our cohort of women aged 30-79 years was 156 per 100,000 person-years. Overall, incidence of breast cancer among users of antihypertensive drugs was no different from the one among non-users (odds ratio (OR): 1.0; 95% confidence interval (CI): 0.9-1.1). Captopril was not associated with a reduced risk of breast cancer (OR: 0.9; 95%CI: 0.6-1.3).


CONCLUSIONS
We did not find any clear association between antihypertensive drugs and risk of breast cancer. Similarly, captopril was not associated with a reduced risk of breast cancer risk.
González-Pérez
Antonio
A
Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain. agonzalez@ceife.es
Ronquist
Gunnar
G
García Rodríguez
Luis Alberto
LA
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D002216:Captopril / Q000009:adverse effects; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D012042:Registries; D006113:United Kingdom / Q000453:epidemiology
D000959:Antihypertensive Agents; D002216:Captopril