The end in sight.
The HP1 heterochromatic protein has become an archetypical example of a chromatin protein recruited by binding a specific histone modification. Surprisingly, recent work in Drosophila reveals that the essential function of HP1 is accomplished by another mode of binding.
Ahmad
Kami
K
Department of BCMP, Harvard Medical School, 240 Longwood Ave, C1-204, Boston, MA 02115, USA.
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004260:DNA Repair; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics; D011485:Protein Binding; D016615:Telomere / Q000378:metabolism*
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D029721:Drosophila Proteins; C452193:heterochromatin protein 1, Drosophila