Epstein-Barr virus-infected malignant T/NK-cell lymphoma in a patient with hypersensitivity to mosquito bites.
We report an autopsy case of Epstein-Barr virus (EBV)-infected malignant lymphoma in a young male who had hypersensitivity to mosquito bites. The autopsy revealed multiple confluent lymphoma lesions in the lungs, and on the right leg irregular-shaped skin ulcers were seen. The left pleural effusion also contained a large number of lymphoma cells. The lymphoma cells were determined as T/NK-cell type cells by immunohistochemistry. EBV DNA was detected most intensively in the lungs and EBV-encoded small RNAs-positive lymphoma cells were also observed in the lungs at a high frequency. EBV latent membrane protein-1 expression and a high Ki-67 labeling indices were noted in the lymphoma cells of the lung lesions. These findings indicate that the development of the malignant lymphoma was associated with the proliferation of EBV-infected lymphoma cells, and the cells that infiltrated the whole the body, especially the lungs, caused the patient's death.
Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Yonago, Japan.
Satoru
S
Kase
Hironobu
H
Adachi
Mitsuhiko
M
Osaki
Masanao
M
Murakami
Takeshi
T
Sairenji
Kiyoshi
K
Hashimoto
Hidemi
H
Teramoto
Shisei
S
Yamamoto
Haruhiko
H
Makino
Eiji
E
Shimizu
Tessin
T
Watanabe
Tokuya
T
Ohsawa
Yoshitaka
Y
Hagari
Motoyuki
M
Mihara
Hisao
H
Ito
D000293:Adolescent; D000818:Animals; D009033:Culicidae / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000473:pathology; D004854:Herpesvirus 4, Human; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007299:Insect Bites and Stings / Q000276:immunology*; D007694:Killer Cells, Natural; D008168:Lung / Q000473:pathology / Q000821:virology; D016399:Lymphoma, T-Cell / Q000821:virology*; D008297:Male; D016133:Polymerase Chain Reaction; D012867:Skin / Q000276:immunology / Q000473:pathology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000473:pathology
D004279:DNA, Viral