Effects of edaravone on reperfusion injury in patients with acute myocardial infarction.
This clinical pilot study was a randomized, controlled, open-label study in 80 patients with acute myocardial infarction and was designed to examine the effects of a novel free radical scavenger, edaravone. Administration of edaravone before myocardial reperfusion was associated with smaller enzymatic infarcts and better clinical outcome.
Department of Cardiology, Fukuoka Tokushukai Medical Center, 4-5 Sugu-kita, Kasuga City, Fukuoka 816-0864, Japan.
Kenichi
K
Tsujita
Hideki
H
Shimomura
Hiroaki
H
Kawano
Jun
J
Hokamaki
Masaya
M
Fukuda
Takuro
T
Yamashita
Satoru
S
Hida
Yoshinori
Y
Nakamura
Yasuhiro
Y
Nagayoshi
Tomohiro
T
Sakamoto
Michihiro
M
Yoshimura
Hidekazu
H
Arai
Hisao
H
Ogawa
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000983:Antipyrine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D000077553:Edaravone; D005260:Female; D016166:Free Radical Scavengers / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis / Q000517:prevention & control*; D010865:Pilot Projects; D015607:Stents; D015912:Thrombolytic Therapy; D016896:Treatment Outcome
D016166:Free Radical Scavengers; D007527:Isoenzymes; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D000077553:Edaravone; D000983:Antipyrine