Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder.
BACKGROUND
This study aims to replicate the sensitivity and specificity of the Mood Disorder Questionnaire (MDQ) for bipolar disorder and assess the impact of insight on the MDQ's sensitivity. Unlike prior telephone-based validation, this is the first clinical study to assess the validity of the MDQ.


METHODS
37 consecutive patients with bipolar spectrum illness received the MDQ, as well as 36 consecutive patients with unipolar depression. MDQ diagnoses were compared to DSM-IV-based SCID diagnoses. A total of 16 bipolar patients also received the Scale to Assess Unawareness of Mental Disorder (SUMD) to measure insight.


RESULTS
Overall sensitivity for the MDQ was 0.58, higher in bipolar I disorder (0.69) than in bipolar II/NOS (0.30, P=0.06). The sample was highly insightful, but the two patients with lowest insight both had false negative screens. Patients' low ratings of severity of mania (question 3 of the MDQ) explained almost half of all false negative results. Specificity was 0.67.


CONCLUSIONS
The MDQ demonstrates good sensitivity in insightful patients with bipolar I disorder, but may be less useful in patients with impaired insight or milder bipolar spectrum conditions.
Miller
Christopher J
CJ
Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA.
Klugman
Jeffry
J
Berv
Douglas A
DA
Rosenquist
Klara J
KJ
Ghaemi
S Nassir
SN
D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D003951:Diagnostic Errors; D005188:False Negative Reactions; D006801:Humans; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D011594:Psychometrics; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires