[The role of IL-18 in allergic rhinitis].
OBJECTIVE
To investigate the roles of IL-18 in the perennial allergic rhinitis (PAR).


METHODS
We measured IL-18 concentration in sera of 30 PAR patients and 20 health control subjects with enzyme-linked immunosorbent assay (ELISA).


RESULTS
The concentration of IL-18 in PAR patients [(424.12 +/- 60. 47) ng/L] was significantly higher compared to health control subjects [(210.71 +/- 57. 37) ng/L](P<0.01) and the concentration of L-18 in PAR patients with asthma [(591.19 +/- 46.54) ng/L] was significantly higher than those without asthma [(352.52 +/- 64.25) ng/L](P<0.05).


CONCLUSIONS
The IL-18 is high in PAR patients and the persistence of elevated IL-18 concentration suggests its role in the expression of persistence and exacerbation of allergic inflammation.
Zhang
Ming
M
Department of Otorhinolaryngology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Liu
Lisi
L
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000150:complications / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood / Q000502:physiology*; D008297:Male; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*
D020382:Interleukin-18