[Effect of chemical toxicants in a wide range of concentrations on the characteristics of lipids of mouse blood erythrocytes].
The lipid composition of blood erythrocytes of mice at days 7 and 31 after a single per os administration of oily hexane-ester extracts with different contents of benzapyrene and polychlorobiphenyls in a wide concentration range was analyzed. It was shown that the parameters of the lipid metabolism in mouse blood erythrocytes depend on the dose of the extract in a nonlinear manner. The administration of extract 3 with a higher content of polychlorobiphenyls at a dose of 5.3 mg/kg and of extract M with a higher content of benzapyrene at the lowest dose of 5.3 x 10(-5) mg/kg had a more pronounced effect on the phospholipid composition of blood erythrocytes. It was shown that the magnitude and direction of changes in the structural state of erythrocyte membranes and the capacity of lipids for oxidation depend on the time elapsed after exposure, the chemical nature of the toxicants, and the dose of the extract.
Urnysheva
V V
VV
Shishkina
L N
LN
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D008055:Lipids / Q000097:blood*; D051379:Mice; D010084:Oxidation-Reduction; D011078:Polychlorinated Biphenyls / Q000633:toxicity*
D008055:Lipids; D001564:Benzo(a)pyrene; D011078:Polychlorinated Biphenyls