Vitamin D receptor gene start codon polymorphism (FokI) is associated with forearm bone mineral density and calcaneal ultrasound in Finnish adolescent boys but not in girls.
We examined the association between vitamin D receptor (VDR) gene FokI polymorphism and bone mineral density and quantitative ultrasound parameters in Finnish adolescents. We assessed bone mineral density at the distal sites of radius and ulna, quantitative ultrasound of the calcaneus, serum concentration of 25-hydroxyvitamin D (25-OHD), calcium intake, physical activity, and BsmI and FokI polymorphisms of the vitamin D receptor gene in 86 girls and 38 boys aged 14 to 16 years. In girls, FokI polymorphism was not significantly associated with bone mineral density or quantitative ultrasound parameters. In adolescent boys, the Ff genotype was associated with higher forearm BMD and calcaneal ultrasound values, when adjusted for body and bone size, BsmI polymorphism, calcium intake, vitamin D status, smoking, and physical activity.
Calcium Research Unit, Department of Applied Chemistry and Microbiology, Division of Nutrition, University of Helsinki, P.O. Box 66, FIN-00014, Finland.
Marika M L
MM
Laaksonen
Merja U M
MU
Kärkkäinen
Terhi A
TA
Outila
Hannu J
HJ
Rita
Christel J E
CJ
Lamberg-Allardt
D000293:Adolescent; D015519:Bone Density / Q000187:drug effects / Q000235:genetics*; D002111:Calcaneus / Q000000981:diagnostic imaging*; D018387:Codon, Initiator; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005260:Female; D005387:Finland; D005542:Forearm / Q000502:physiology*; D005828:Genetics, Population; D006801:Humans; D008019:Life Style; D008297:Male; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D014463:Ultrasonography; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
D018387:Codon, Initiator; D018167:Receptors, Calcitriol; D014807:Vitamin D; C104450:25-hydroxyvitamin D; C053864:endodeoxyribonuclease BsmI; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific