A palladium-catalyzed enantioselective alkylative desymmetrization of meso-succinic anhydrides.
Monoalkylation of cyclic anhydrides provides an opportunity to couple a carbon-carbon bond-forming event with the control of backbone stereochemistry. We have developed a palladium-JOSIPHOS catalyst system that desymmetrizes meso-succinic anhydrides using organozinc reagents as nucleophiles, and have found that, in many cases, this reaction proceeds at ambient temperature.
Bercot
Eric A
EA
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Rovis
Tomislav
T