[Benefit of assessment of cytokines in inflammatory postoperative complications (review)].
Systemic inflammatory response syndrome and the resulting complications continue to be important causes of morbidity in surgical patients. A favourable prognosis of patients with postoperative inflammatory intraabdominal complications is limited by forwardness if diagnosis of this severe complication. Cytokines play a significant role not only in regulating pathogenic mechanisms, during the rising of SIRS, but can themselves directly lead to tissue damage. Increased concentrations of inflammatory cytokines observed in the initial phase of postoperative complications have great significance in the early diagnosis of systemic complications. Procalcitonin, alongside to cytokines, appears as a significant parameter. Despite lots of its pathophysiological points are unclear it is a highly selective and specific indicator of systemic bacterial inflammation. Leptin is not only a hormone of adipocytes but also a member of inflammatory network of cytokines and acute phase reactants. Leptin is possibly a necessary factor for adequate course of acute phase reaction. Proinflammatory cytokines as interleukin-1 or tumour necrosis factor-alpha are the main regulatory factors of leptin in this period.
I. chirurgická klinika 1, lékarské fakulty Univerzity Karlovy a Vseobecné fakultní nemocnice. ichachkhiani@hotmail.com
Ivane
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Chachkhiani
D000209:Acute-Phase Proteins / Q000502:physiology; D002116:Calcitonin / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000502:physiology; D011183:Postoperative Complications; D011498:Protein Precursors / Q000502:physiology; D013514:Surgical Procedures, Operative; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology*
D000209:Acute-Phase Proteins; C000606589:CALCA protein, human; D016207:Cytokines; D020738:Leptin; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide