Experimental models of uveal melanoma.
Over the past several decades, considerable effort has been directed toward developing suitable experimental models for the study of uveal melanoma. Animal models of uveal melanoma have undergone many improvements, leading to the development of experimental systems that better represent the disease in human beings. A major advance has come from the use of human uveal melanoma cell lines capable of inducing tumour growth and metastatic disease in immunodeficient hosts. Knowledge gained from the use of experimental models will ultimately be translated into better diagnostic and therapeutic strategies for patients with uveal melanoma. In this review the authors describe the current state-of-the-art designs of experimental models of uveal melanoma, highlighting the advantages and disadvantages of the available models. Novel findings from a rabbit model of uveal melanoma are also presented.
Blanco
Paula L
PL
Henry C. Witelson Ophthalmic Pathology Laboratory and Registry, McGill University, Montreal, Que. paublanco@hotmail.com
Caissie
Amanda L
AL
Burnier
Miguel N
MN
D000818:Animals; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D023421:Models, Animal; D014604:Uveal Neoplasms / Q000473:pathology*