Pyridylthiocarbazide complexes of rhenium with potential radiopharmaceutical applications.
Attachment of a thioamide tethering group provides a modification of the well-known pyridylhydrazine based route to radiolabelling of biomolecules (the HYNIC system) and gives a proligand which gives stable, well-defined chelated derivatives with both Re(v) oxo and Re(III) diazenide cores. Both display previously unknown bonding modes for the pyridylthiocarbazide ligands.
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.
Carole
C
Clarke
Andrew R
AR
Cowley
Jonathan R
JR
Dilworth
Paul S
PS
Donnelly
D018360:Crystallography, X-Ray; D006834:Hydrazines / Q000737:chemistry*; D007202:Indicators and Reagents; D007553:Isotope Labeling; D008958:Models, Molecular; D011868:Radioisotopes; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*
D006834:Hydrazines; D007202:Indicators and Reagents; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium