[Clinical observation on treatment of diabetic nephropathy with compound fructus arctii mixture].
OBJECTIVE
To observe the effect of Compound Fructus Arctii Mixture (FAM, consisted of Fructus Arctii and ethanol extract of Radix Astragalus membranaceus) in treating diabetic nephropathy.


METHODS
Using FAM to treat 31 patients with diabetic nephropathy and controlled by 23 patients treated with Losartan, the therapeutic course was 3 months for both groups, changes of clinical symptoms, blood glucose, lipid metabolism and urinary albumin were observed and compared.


RESULTS
The total effective rate in the treated group was 80.6% while in the control group 65.2%. The symptoms, urinary protein and albumin as well as lipid metabolism in the treated group all significantly improved after treatment (P<0.05), but in the control group improvement only showed in urinary albumin level (P<0.05).


CONCLUSIONS
FAM has the effects of reducing urinary protein in 24 hrs, lowering urinary albumin, improving blood glucose after meal and lipid metabolism.
Wang
Hai-ying
HY
Shanghai University of TCM, Shanghai 201203. wanghaiying_7@hotmail.com
Chen
Yi-ping
YP
D000328:Adult; D000419:Albuminuria / Q000188:drug therapy; D027885:Astragalus propinquus; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D005663:Furans / Q000627:therapeutic use; D005960:Glucosides / Q000627:therapeutic use; D006801:Humans; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; D005663:Furans; D005960:Glucosides; D019808:Losartan; C077992:arctiin