Hemorrheologic changes induced by aqueous extract of Ligaria cuneifolia: treatment by two different administration routes.
Ligaria cuneifolia (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. This work focuses on the hemorrheologic parameters in the treatment with an aqueous extract of Ligaria cuneifolia (Lc) by two different administration routes: intraperitoneal (i.p.) and intravenous (i.v.). Adult male Wistar rats were injected by via i.p. or by via i.v. with: saline solution; 2.5 mg/100 g body weight of Lc and 5.5 mg/100 g body weight of Lc. The relative viscosity of blood (eta r)(45/Hct) was measured showing that Lc-treatment by via i.p. produced an increase of about 69% while Lc by via i.v. enhanced the parameter about 47%. All of Lc-treated animals showed a significant increase in the rigidity index (RI). The mean corpuscular hemoglobin concentration (MCHC) exhibited an increase of about 15% in all the treated groups. Lc-treatment by via i.p. produced a diminution of plasma cholesterol level associated with RI augmentation which induced an increase of (eta r)(45/Hct). By via i.v. Lc produces both RI and (eta r)(45/Hct) augmentation by increasing MCHC but without modifying plasma cholesterol level, indicating a direct Lc-action on the internal viscosity of the erythrocyte.
Cát. Biofísica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Alicia
A
Dominighini
Mariana
M
Ferrero
Guillermo
G
Mengarelli
María Teresa
MT
Ronco
María
M
de Luján Alvarez
Marcelo
M
Wagner
Alberto
A
Gurni
Cristina
C
Carnovale
Alejandra
A
Luquita
D000818:Animals; D001118:Argentina; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001809:Blood Viscosity / Q000187:drug effects; D002756:Cholagogues and Choleretics / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D004353:Drug Evaluation, Preclinical; D004909:Erythrocyte Indices / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D018056:Hemorheology / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects; D028183:Loranthaceae / Q000737:chemistry*; D008297:Male; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014867:Water
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D010936:Plant Extracts; D014867:Water; D002784:Cholesterol