[Effect of niupo zhibao pellet on transforming growth factor-beta1 and its receptor's expression in endotoxic shock rats with lung injury].
OBJECTIVE
To observe the influence of Niupo Zhibao pellet (NZP) on transforming growth factor-beta1 (TGF-beta1) and its receptor's expression.


METHODS
Endotoxic shock model was established by intravenous injection of lipopolysaccharide (LPS) 1.5 mg/kg and intraperitoneal injection of D-galactosamine 100 mg/kg, and intervened by NZP, TGF-beta1 and its receptor's expression in lung tissue were detected by immunohistochemical method.


RESULTS
NZP could enhance the TGF-beta1 and its receptor's expression in endotoxic shock lung tissue, and reduce the injury of lung.


CONCLUSIONS
The mechanism of NZP in reducing endotoxic shock lung injury is possibly related with its effect in enhancing the TGF-beta1 and its receptor's expression in lung tissue.
Du
Shao-hui
SH
Department of Internal Medicine, Shenzhen Hospital Affiliated to Guangzhou TCM University, Guangdong 518033. dushaohui@163.net
Xu
Zhi-wei
ZW
Chen
Dong-feng
DF
Li
Hui
H
Li
Yiwei
Y
Liao
Xin
X
Wei
Zhijun
Z
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005688:Galactosamine; D008070:Lipopolysaccharides; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018125:Receptors, Transforming Growth Factor beta / Q000096:biosynthesis*; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000378:metabolism*; D012772:Shock, Septic / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*; D053773:Transforming Growth Factor beta1
D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D018125:Receptors, Transforming Growth Factor beta; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D005688:Galactosamine