New medication treatment options for bipolar disorders.
OBJECTIVE
To assess new treatment options for bipolar disorders.


METHODS
Controlled studies of new treatments for bipolar disorders were identified by computerized searches and reviews of scientific meeting proceedings, and were compiled by drug category.


RESULTS
Two main categories of medications, newer anticonvulsants and newer antipsychotics, are yielding emerging new treatment options for bipolar disorders. Newer anticonvulsants have diverse psychotropic profiles, and although not generally effective for acute mania, may have utility for other aspects of bipolar disorders (e.g. lamotrigine for maintenance or acute bipolar depression), or for comorbid conditions (e.g. gabapentin for anxiety or pain, topiramate for obesity, bulimia, alcohol dependence, or migraine, and zonisamide for obesity). In contrast, newer antipsychotics generally appear effective for acute mania, and some may ultimately prove effective in acute depression (e.g. olanzapine combined with fluoxetine, quetiapine) and maintenance (e.g. olanzapine).


CONCLUSIONS
Emerging research is yielding new treatment options for bipolar disorders and comorbid conditions.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA. tketter@stanford.edu
T A
TA
Ketter
P W
PW
Wang
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Nowakowska
W K
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Marsh
D000927:Anticonvulsants / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D004361:Drug Tolerance; D006801:Humans
D000927:Anticonvulsants; D014150:Antipsychotic Agents