The basic science of glomus jugulare tumors.
Glomus tumors are a fascinating group of lesions. It is a challenge for neurosurgeons and otolaryngologists to resect them completely with minimal morbidity. Laboratory researchers have discovered extremely interesting genetic and molecular biology factors involved in the development and growth of glomus tumors. In this article the author reviews the genetics, protein mutations, angiogenesis and apoptosis associated with tumor formation, and the secretion of vasoactive substances is discussed as well. It is hoped that with further research less invasive measures may be developed to treat these tumors.
Heth
Jason
J
Department of Neurosurgery, University of Michigan, Taubman Medical Center, Ann Arbor, Michigan 48109, USA. jheth@umich.edu
D017209:Apoptosis; D002395:Catecholamines / Q000096:biosynthesis / Q000378:metabolism; D015687:Cell Hypoxia; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D042963:Electron Transport Complex II / Q000235:genetics; D018392:Genomic Imprinting; D005925:Glomus Jugulare Tumor / Q000098:blood supply / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D009389:Neovascularization, Pathologic; D010673:Pheochromocytoma / Q000235:genetics; D021122:Protein Subunits / Q000235:genetics; D017481:Receptors, Somatostatin / Q000378:metabolism; D013385:Succinate Dehydrogenase
D002395:Catecholamines; D008565:Membrane Proteins; D021122:Protein Subunits; D017481:Receptors, Somatostatin; C491545:SDHD protein, human; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase