[Immunopathogenesis of diabetes mellitus I].
The pathogenesis of diabetes mellitus I is multifactorial. Both genetic predisposition and environmental factors are involved in the deregulation of immune system with subsequent breakage of self-tolerance. Autoantibodies against numerous autoantigens are raised during this long-term process but the principal pathogenic mechanism is cytotoxic killing of beta cells of pancreas mediated predominantly by T cells. There could be the chance to interrupt this pathogenetic process by manipulation with immune system to achieve induction of tolerance. Such clinical trials are now under progress.
Krejsek
J
J
Ustav klinické imunologie a alergologie Lékarské fakulty UK a FN, Hradec Králové.
Novosad
J
J
Kopecký
O
O
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D020022:Genetic Predisposition to Disease; D006801:Humans