Block of T -Type Ca(2+) Channels Is an Important Action of Succinimide Antiabsence Drugs.
The role of calcium channel blockade in the antiepileptic action of ethosuximide is controversial, especially regarding the potency and efficacy of block. However, recent evidence obtained from transgenic animals and heterologous expression systems supports a major role of T-type calcium channels in both the generation of absence seizures and the action of ethosuximide in human absence epilepsy.
Huguenard
John R.
JR
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.