Organization of diencephalic projections from the spinal trigeminal nucleus oralis: an anterograde tracing study in the rat.
The organization of the efferent projections from the spinal trigeminal nucleus oralis (Sp5O) to the diencephalon was studied in the rat using the anterograde tracer Phaseolus vulgaris leucoagglutinin. The present study confirms the existence of trigemino-thalamic pathways originating from the Sp5O and details their distribution. The main diencephalic targets of the Sp5O are the ventral posteromedial thalamic nucleus (VPM), the posterior thalamic nuclei (Po) and the ventral part of the zona incerta (ZIv), contralaterally, and the parvicellular part of the ventral posterior thalamic nucleus (VPpc), bilaterally. The distribution of these projections varies according to the dorso-ventral location of the injection sites: the dorsal part of the Sp5O projects to the medial part of the VPM and the Po, and to the caudal part of the ZIv, as well as to the VPpc. The ventral part of the Sp5O projects to the lateral part of the VPM and the Po and to the rostral part of the ZIv. These results suggest that the trigemino-diencephalic pathways originating from the Sp5O are involved in the processing of gustatory and somatosensory information.
INSERM E 0216, Neurobiologie de La Douleur Trigéminale, Faculté de Chirurgie Dentaire, 11 Bd Charles de Gaulle, 63000 Clermont-Ferrand, France.
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D000818:Animals; D004027:Diencephalon / Q000737:chemistry* / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000737:chemistry / Q000502:physiology; D027805:Phaseolus / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling / Q000379:methods; D014279:Trigeminal Nucleus, Spinal / Q000737:chemistry* / Q000502:physiology*