[A new procedure in making reliable experimental models of gastroesophageal reflux].
OBJECTIVE
To provide a reliable experimental model for gastroesophageal reflux (GER) study.


METHODS
Twenty Japan 5-month-old male rabbits were randomly divided into two groups: group cardiomyotomy (n=10), group partial cardiomyectomy (n=10). The operations of cardiomyotomy and parital cardiomyectomy were performed in 2 groups respectively. All the animals underwent intraesophageal pH detection 1 week before operation and 4 weeks after operation. The mean changes of reflux ratios were compared between before operation and after operation.


RESULTS
In gastroesophageal reflux ratio between before operation and after operation, there was no significant difference in group cardiomyotomy (1.98%+/-1.52% and 4.32%+/-2.39%, P>0.05) and there was significant difference in group partial cardiomyectomy (1.56%+/-1.57% and 13.56%+/-3.27%, P<0.05).


CONCLUSIONS
The reliable experimental model of GER can be made with procedure of partial cardiomyectomy. It can be used in estimating the operative procedure of anti-reflux and is conducive to dynamic observation and study of esophagitis.
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China.
Zhicheng
Z
Xu
Tingze
T
Hu
Wenying
W
Liu
D000818:Animals; D004195:Disease Models, Animal; D004941:Esophagitis / Q000209:etiology; D005764:Gastroesophageal Reflux / Q000150:complications; D008297:Male; D011817:Rabbits; D011897:Random Allocation