Oral tandospirone and clonidine provide similar relief of preoperative anxiety.
OBJECTIVE
To compare oral tandospirone with oral clonidine in terms of preoperative anxiolysis.


METHODS
Preoperative anxiety was measured using the Spielberger state-trait anxiety inventory (STAI-state). Pretreatment evaluation was performed on the day before surgery and post-treatment examination immediately after entry into the operating room. In a double-blind, randomized design, three groups of 40 patients received one of the following oral medications 90 min before entry into the operating room: 1) tandospirone 10 mg (T group); 2) clonidine 3 microg.kg(-1) (C group); or 3) placebo (P group).


RESULTS
Following premedication, the STAI-state decreased in the T group (P < 0.05) while exhibiting no significant changes in the C group. As far as the changes in the STAI-state were concerned, however, the P-group was different from each of the other groups (P < 0.05 vs T group and vs C group).


CONCLUSIONS
Oral tandospirone was equivalent to oral clonidine in terms of reduction in preoperative anxiety.
Department of Anesthesiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan.
Aya
A
Iizawa
Tsutomu
T
Oshima
Yoshiko
Y
Kasuya
Shuji
S
Dohi
D000284:Administration, Oral; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001007:Anxiety / Q000517:prevention & control*; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D054833:Isoindoles; D008297:Male; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010555:Personality Inventory; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011229:Preanesthetic Medication / Q000379:methods; D011300:Preoperative Care / Q000379:methods*; D011597:Psychomotor Performance; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*
D000700:Analgesics; D014151:Anti-Anxiety Agents; D054833:Isoindoles; D010879:Piperazines; D011743:Pyrimidines; C055267:tandospirone; D003000:Clonidine