Biphasic modulation of behavioral nociceptive responses by morphine in adult mice after amputation.
Amputation of a segment of the tail produced long-lasting changes in nociception and morphine-induced antinociception. Plastic changes in nociceptive transmission may occur at the spinal cord as well as supraspinal structures after tail amputation. Acute hyperalgesia is detected at the remaining part of the tail as well as hindpaw. Morphine induced facilitation of the hot-plate (HP) response at a low dose and a greater dose of morphine is required to produce complete inhibition of the HP response. Since these effects happen at five weeks after the surgery, tail amputation may serve as a mouse model for studying long-term plastic changes in central nervous system after amputation.
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King's College Circle, University of Toronto, Toronto, Canada, M5S 1A8.
Susan
S
J  Kim
Min
M
Zhuo
D000671:Amputation, Surgical / Q000009:adverse effects; D000818:Animals; D006930:Hyperalgesia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology*; D013623:Tail
D009292:Narcotic Antagonists; D009020:Morphine