Human caliciviruses as a cause of severe gastroenteritis in Peruvian children.
To define the role of human caliciviruses (HuCVs) in severe childhood gastroenteritis, fecal and paired serum samples from 233 Peruvian children hospitalized with gastroenteritis (case patients) and fecal samples from 248 control subjects were evaluated. Overall, 128 case patients (55%) demonstrated HuCV infection by either fecal (n=81 [35%]) or serological (n=96 [41%]) testing. HuCVs were more prevalent in fecal samples from case patients than those from control subjects (35% vs. 13%; P<.001). HuCV infection was more prevalent among case patients without another pathogen than in those who had a coinfecting pathogen (77% [40/52] vs. 49% [88/181]; P<.001). HuCVs appear to be an important cause of gastroenteritis in Peruvian children.
Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. uap2@cdc.gov
Umesh D
UD
Parashar
Jin-Fen
JF
Li
Rosa
R
Cama
Mark
M
DeZalia
Stephan S
SS
Monroe
David N
DN
Taylor
Dante
D
Figueroa
Robert H
RH
Gilman
Roger I
RI
Glass
D000914:Antibodies, Viral / Q000097:blood; D002139:Caliciviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D017250:Caliciviridae Infections / Q000821:virology*; D016022:Case-Control Studies; D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000821:virology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010568:Peru; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D044967:Serum / Q000821:virology
D000914:Antibodies, Viral; D012367:RNA, Viral