[Effects of two trypanosomicide drugs, gention violet and WR6026, on platelet concentrates preservation].
In order to verify the viability of platelet concentrate during its preservation period when added with two trypanosomicidal chemical substances, gentian violet and quinoline WR6026, we tested these concentrates and verified the following parameters: number of platelets, pH and platelet aggregation test with a pair of agonists. Significant alterations were observed in the platelet concentrate treated with gentian violet suggesting important damage to the platelet viability. With WR6026 similar values to the controls were observed, opening new perspectives for the utilization of this salt for the chemoprophylaxis of transfusional Chagas' disease in highly endemic regions.
Faculdade de Medicina do Triângulo Mineiro e Hemocentro Regional de Uberaba, Uberaba, MG. hemocentro@met.com.br
Sheila
S
Soares
Hélio
H
Moraes-Souza
Maria Aparecida Vieira
MA
Tostes
Dayse Maria
DM
Lourenço
D000634:Aminoquinolines / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D001793:Blood Preservation / Q000379:methods*; D005840:Gentian Violet / Q000494:pharmacology*; D006801:Humans; D010976:Platelet Count; D013997:Time Factors; D014344:Trypanocidal Agents / Q000494:pharmacology*
D000634:Aminoquinolines; D014344:Trypanocidal Agents; D005840:Gentian Violet; C080436:8-aminoquinoline