Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto beta-boswellic acid (KBA), acetyl beta-boswellic acid and beta-boswellic acid has been evaluated for antianaphylactic and mast cell stabilizing activity using passive paw anaphylaxis and compound 48/80 induced degranulation of mast cell methods. The extract inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner (20, 40 and 80 mg/kg, po). However, the standard dexamethasone (0.27 mg/kg, po) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependant manner (20, 40 and 80 mg/kg, po) was observed thus showing mast cell stabilizing activity. The standard disodium cromoglycate (50 mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA. The results suggest promising antianaphylactic and mast cell stabilizing activity of the extract.
Pungle
Pratibha
P
C. U. Shah College of Pharmacy, Sir Vithaldas Vidya Vihar, SNDT Women's University, Juhu, Santacruz (W), Mumbai 400 049, India.
Banavalikar
M
M
Suthar
A
A
Biyani
M
M
Mengi
S
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000707:Anaphylaxis / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D029743:Boswellia / Q000737:chemistry*; D015550:Cell Degranulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D014315:Triterpenes; C054625:boswellic acid