Decreases of blood oxygenation level--dependent signal in the activated motor cortex during functional recovery after resection of a glioma.
The present case demonstrates that the blood oxygenation level-dependent (BOLD) signal intensity can decrease in the activated motor cortex on the lesion side (left) of a patient with a left frontal glioma during functional recovery after surgery. Near-infrared spectroscopy revealed that the decrease of BOLD signal was associated with increases of cerebral blood volume and deoxyhemoglobin concentrations in the cerebral vessels. This implies that the interpretation of results obtained by functional MR imaging in patients with brain disorders must take into consideration such atypically evoked cerebral blood oxygenation changes, which do not increase the BOLD signals.
Department of Neurosurgery, Nihon University School of Medicine, Tokyo, Japan.
Yoshihiro
Y
Murata
Kaoru
K
Sakatani
Yoichi
Y
Katayama
Norio
N
Fujiwara
Tatsuya
T
Hoshino
Chikashi
C
Fukaya
Takamitsu
T
Yamamoto
D000328:Adult; D001132:Arm / Q000294:innervation; D001254:Astrocytoma / Q000473:pathology / Q000601:surgery*; D001810:Blood Volume / Q000502:physiology; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005145:Face / Q000294:innervation; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D006429:Hemiplegia / Q000503:physiopathology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D009361:Neoplasm Invasiveness / Q000473:pathology; D010100:Oxygen / Q000097:blood*; D011183:Postoperative Complications / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared
D006454:Hemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen