Intercontinental spread of pyrimethamine-resistant malaria.
Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.
Roper
Cally
C
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. cally.roper@lshtm.ac.uk
Pearce
Richard
R
Nair
Shalini
S
Sharp
Brian
B
Nosten
François
F
Anderson
Tim
T
D000349:Africa; D000483:Alleles; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D001210:Asia, Southeastern; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance / Q000235:genetics; D004359:Drug Therapy, Combination; D019143:Evolution, Molecular; D017125:Genes, Protozoan; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology* / Q000517:prevention & control; D018895:Microsatellite Repeats; D009154:Mutation; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D011739:Pyrimethamine / Q000494:pharmacology* / Q000627:therapeutic use; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*
D000962:Antimalarials; D002738:Chloroquine; D013762:Tetrahydrofolate Dehydrogenase; D011739:Pyrimethamine