The Maillard reaction inhibitors and their biological and therapeutic significance.
The formation of AGE crosslinks as a result of the Maillard reaction is reduced by several drugs (aminoguanidine, OPB-9195, tenilsetam, aspirin), substances of natural origin (carnosine, homocarnosine) and antioxidants. These compounds are the Maillard reaction inhibitors, but do not seem to break AGE-derived protein crosslinks, which have already formed and therefore will not be effective in patients with a long history of the disease. The first in a new class of compounds that have been shown the ability to chemically reverse the Maillard reaction is PTB. This compound breaks the carbon-carbon bond between two carbonyls of glucose-derived protein crosslinks.
Sztanke
Krzysztof
K
Department of Synthesis and Technology of Drugs, Medical University of Lublin.
Pasternak
Kazimierz
K
D000375:Aging / Q000378:metabolism; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000096:biosynthesis*; D006801:Humans; D015416:Maillard Reaction / Q000187:drug effects*; D013844:Thiazoles / Q000494:pharmacology*
D017127:Glycation End Products, Advanced; D013844:Thiazoles