Language-related brain function during word repetition in post-stroke aphasics.
We compared fMRI findings (using SPM99) obtained with repetition task in normal subjects with those of two patients with Broca's and Wernicke's aphasia who received speech therapy and showed complete recovery. Both aphasic patients with left hemisphere damage who showed complete recovery exhibited activation of only the compensatory area in the right hemisphere during the repetition task. Recovery from Broca's aphasia involves reorganization and neuromodulation between the external temporopolar area and the anterior superior temporal area of the superior temporal gyrus, putamen and the inferior frontal gyrus, while that from Wernicke's aphasia involves reorganization and neuromodulation between the superior temporal gyrus of the temporal region, the posterior supramarginal gyrus and inferior parietal lobule of the parietal region.
Department of Rehabilitation Medicine, Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. abo@jikei.ac.jp
Masahiro
M
Abo
Atushi
A
Senoo
Shu
S
Watanabe
Satoshi
S
Miyano
Keiko
K
Doseki
Nobuyuki
N
Sasaki
Kazushige
K
Kobayashi
Yoshiaki
Y
Kikuchi
Kyozo
K
Yonemoto
D000328:Adult; D001039:Aphasia, Broca / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D007802:Language; D007807:Language Tests; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013070:Speech Therapy / Q000379:methods; D020521:Stroke / Q000150:complications / Q000628:therapy; D014705:Verbal Behavior / Q000502:physiology*