[Semisolid theophylline matrices containing polyethyleneglycols. 2. Determination of molecular mass of the binary PEG].
Previous work on the kinetics of theophylline release from semi-solid matrices based on PEG demonstrated that binary PEG mixes enable significant dissolution associated with strong viscosity. The present work was aimed to explain this singular property and indicated that the "virtual" mass of binary PEG is close to 2500-3000 and that theophylline release from semi-solid matrices based on PEG is not associated with vehicle mass, i.e. PEG, but rather with another independent latent variable.
Laboratoire de Pharmacie Galénique, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, 15, avenue Charles-Flahault, BP 14491, F34093 Montpellier Cedex 5.
C A
CA
Ortigosa
Y J
YJ
Lasserre
D001993:Bronchodilator Agents / Q000737:chemistry*; D005079:Excipients; D016014:Linear Models; D008970:Molecular Weight; D011092:Polyethylene Glycols; D012995:Solubility; D013806:Theophylline / Q000737:chemistry*
D001993:Bronchodilator Agents; D005079:Excipients; D011092:Polyethylene Glycols; D013806:Theophylline