APOE-epsilon4 predicts dementia but not other psychiatric disorders after traumatic brain injury.
The authors studied the association between APOE-epsilon4 genotype and axis I and II psychiatric disorders an average of 30 years after traumatic brain injury. Sixty patients were dichotomized into subjects with and without APOE-epsilon4 allele. Dementia and subclinical dementia were significantly more common with the presence of APOE-epsilon4. The occurrence of other psychiatric disorders did not differ between patients with and without APOE-epsilon4 allele.
Department of Psychiatry, Turku University Hospital, PL 52, FIN-20521 Turku, Finland. salla.koponen@utu.fi
S
S
Koponen
T
T
Taiminen
V
V
Kairisto
R
R
Portin
H
H
Isoniemi
S
S
Hinkka
O
O
Tenovuo
D000368:Aged; D000483:Alleles; D000647:Amnesia / Q000453:epidemiology / Q000209:etiology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001930:Brain Injuries / Q000150:complications* / Q000453:epidemiology; D003704:Dementia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors; D013997:Time Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E