The concentration of lipids, lipoproteins and apolipoproteins in cord blood serum of newborns in the course of intrauterine period.
The period of foetal life as the first stage in the individual development is very important for every man. This is a period in which the greatest dynamics of developmental changes and particularly great susceptibility to the influence of negative factors are observed. The exponent of the correct prenatal life of the foetus is the birth weight of a newborn, which defines the degree of biological maturity of the child and its ability to live in the course of the subsequent stages of individual life. Therefore, the aim of the present study was to check the influence of foetal life on some of the parameters of lipids metabolism in the cord blood serum in healthy newborns as well as the evaluation of the concentration of lipids, lipoproteins and apolipoproteins with relation to the birth weight and also the gestational age of the studied newborns. The study was carried out on 137 healthy newborns (63 boys and 74 girls). In all of the studied newborns concentration of triglycerides, total cholesterol, LDL-cholesterol, VLDL-cholesterol and HDL-cholesterol as well as of apolipoproteins (apo-Al, apo-B) in the cord blood serum sampled soon after birth was studied. In the cord blood serum of the LBW newborns higher values of triglycerides, total cholesterol, cholesterol in fraction VLDL and apolipoprotein B were confirmed as well as the tendency towards lower values of HDL-cholesterol, which is an unfavourable phenomenon from the point of the risk of arteriosclerosis. No statistically significant differences in the level of lipids, lipoproteins and apolipoproteins in cord blood serum of the studied newborns depending on their gestational age were confirmed. The results may suggest that the risk factors of cardiovascular disease may to great extent depend on the intrauterine development and low birth weight.
Department of Paediatric Propedeutics, Medical University of Lublin.
Elzbieta
E
Pac-Kozuchowska
D001053:Apolipoproteins / Q000097:blood*; D001724:Birth Weight; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D012016:Reference Values; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides