In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis.
The minimum inhibitory concentrations (MIC, microg ml-1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC-2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC-0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125-1 and 0.06-0.5 microg ml-1 for A. niger (22 strains), 0.06-0.25 and 0.06-0.125 microg ml-1 for A. flavus (10 strains), 0.125 and 0.125-0.5 microg ml-1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.
Karaarslan
A
A
Department of Microbiology and Clinical Microbiology, Ankara University Medical School, Ankara, Turkey. karaars@medicine.ankara.edu.tr
Arikan
S
S
Ozcan
M
M
Ozcan
K M
KM
D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D004424:Ear Canal / Q000382:microbiology*; D004427:Ear Diseases / Q000382:microbiology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology*; D009281:Naphthalenes / Q000494:pharmacology*; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D000077291:Terbinafine