A probabilistic estimation of fluoride intake by infants up to the age of 4 months from infant formula reconstituted with tap water in the fluoridated regions of Ireland.
Two probabilistic models were developed to estimate the acute and chronic exposure to fluoride of exclusively formula-fed infants aged 0-4 months as a result of the consumption of infant formula reconstituted with fluoridated tap water in Ireland. The estimates were based on calculated infant formula consumption and accepted body weight standards, together with reported concentrations of fluoride in infant formula powder and measured values for the fluoride content of water in Ireland. The mean acute exposure of infants to fluoride on any single day in areas served by 387 fluoridated water supplies was estimated to be between 0.11 and 0.14 mg/kg body weight depending on age group (95th percentiles 0.2 and 0.26 mg/kg b.w., respectively). These predicted intakes were well below the intake of fluoride associated with acute toxic effects, which is considered to be 5 mg fluoride (F(-))/kg body weight. The mean chronic exposure of infants to fluoride was estimated to be between 0.106 and 0.170 mg/kg b.w./day depending on body weight (95th percentiles 0.108 and 0.172 mg/kg b.w./day, respectively). This estimate described the average daily fluoride intake of infants during the first 4 months of life residing in the areas served by 226 water supplies that achieved an average yearly fluoride concentration below 1.03 mg/l. Dental fluorosis may be considered to be the only risk at these low doses and from our work it is estimated that there is a very low risk of moderate dental fluorosis of the permanent dentition in infants exposed to fluoride at these levels.
Food Safety Authority of Ireland, Lower Abbey Street, Dublin, Ireland. wanderson@fsai.ie
W A
WA
Anderson
I
I
Pratt
M R
MR
Ryan
A
A
Flynn
D000367:Age Factors; D001835:Body Weight; D002327:Cariostatic Agents / Q000032:analysis / Q000493:pharmacokinetics*; D004781:Environmental Exposure; D005457:Fluoridation; D005459:Fluorides / Q000032:analysis / Q000493:pharmacokinetics*; D009050:Fluorosis, Dental / Q000209:etiology; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry; D007231:Infant, Newborn; D007494:Ireland; D015233:Models, Statistical; D011336:Probability; D012307:Risk Factors; D014867:Water / Q000737:chemistry; D014881:Water Supply / Q000032:analysis
D002327:Cariostatic Agents; D014867:Water; D005459:Fluorides