Mechanisms of neuroprotective action of vitamin D(3).
This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D(3) and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D(3), in the nervous system.
Center of Physiology and Biochemical Research, Kiev 01042, Ukraine. cpbr@mail.ru
A V
AV
Kalueff
K O
KO
Eremin
P
P
Tuohimaa
D000818:Animals; D002117:Calcitriol / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D002762:Cholecalciferol / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D009420:Nervous System / Q000378:metabolism*; D009424:Nervous System Physiological Phenomena; D018167:Receptors, Calcitriol / Q000378:metabolism / Q000502:physiology
D018167:Receptors, Calcitriol; D002762:Cholecalciferol; D002117:Calcitriol