[Botulinum toxin injection-treatment of upper lid retraction in thyroid eye disease].
OBJECTIVE
Upper lid retraction associated with thyroid eye disease may result in conjunctival and corneal exposure as well as in an esthetic problem. We evaluated the effect of botulinum toxin injections in order to lower the upper lid.


METHODS
This prospective study included 19 eyes of 13 female patients presenting with scleral exposure aged 28-50 years. We injected 5-15 IE botulinum toxin A (Botox) transconjunctivally into the levator muscle. Lid position, negative side effects, and patient satisfaction were evaluated.


RESULTS
Lid retraction improved from 2.4 mm (+/-1.4 mm) prior to injection to 0.5 mm (+/-2.3 mm) 4 weeks after injection. In 11 of 19 eyes 4 weeks after injection and in 8 of 14 eyes 12 weeks after injection scleral exposure had resolved. Diplopia did not occur and tear production was not influenced. Two eyes had transient ptosis. Lid lag increased from 0.34 (+/-0.6 mm) to 0.84 mm (+/-0.9 mm). Of 13 patients, 8 were satisfied with the result.


CONCLUSIONS
Botulinum toxin A injection provides effective treatment especially in mild lid retraction and as a temporary solution for patients with unstable thyroid disease.
Augenklinik, Universität, Würzburg. TannjaDintelmann@gmx.de
T
T
Dintelmann
J
J
Sold
F
F
Grehn
D000328:Adult; D001763:Blepharoptosis / Q000139:chemically induced / Q000175:diagnosis; D001905:Botulinum Toxins / Q000008:administration & dosage* / Q000009:adverse effects; D003228:Conjunctiva; D004483:Ectropion / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012008:Recurrence; D016896:Treatment Outcome
D001905:Botulinum Toxins