Human caliciviruses as a cause of severe gastroenteritis in Peruvian children.
To define the role of human caliciviruses (HuCVs) in severe childhood gastroenteritis, fecal and paired serum samples from 233 Peruvian children hospitalized with gastroenteritis (case patients) and fecal samples from 248 control subjects were evaluated. Overall, 128 case patients (55%) demonstrated HuCV infection by either fecal (n=81 [35%]) or serological (n=96 [41%]) testing. HuCVs were more prevalent in fecal samples from case patients than those from control subjects (35% vs. 13%; P<.001). HuCV infection was more prevalent among case patients without another pathogen than in those who had a coinfecting pathogen (77% [40/52] vs. 49% [88/181]; P<.001). HuCVs appear to be an important cause of gastroenteritis in Peruvian children.
Parashar
Umesh D
UD
Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. uap2@cdc.gov
Li
Jin-Fen
JF
Cama
Rosa
R
DeZalia
Mark
M
Monroe
Stephan S
SS
Taylor
David N
DN
Figueroa
Dante
D
Gilman
Robert H
RH
Glass
Roger I
RI
D000914:Antibodies, Viral / Q000097:blood; D002139:Caliciviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D017250:Caliciviridae Infections / Q000821:virology*; D016022:Case-Control Studies; D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000821:virology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010568:Peru; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D044967:Serum / Q000821:virology
D000914:Antibodies, Viral; D012367:RNA, Viral