The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies.
Cerebral glucose metabolic mapping using positron emission tomography (PET) and 2-[18F]fluoro-2-deoxyglucose (FDG) has been extensively studied in the epilepsies. Regions of interictal glucose hypometabolism are highly associated with cerebral sites of seizure generation-propagation in focal epilepsies. The volume of reduced glucose metabolism is often widespread and even bilateral in focal epilepsies, although ictal onset zones typically are located at the sites of most severe hypometabolism within a larger volume of hypometabolism.
Department of Neurology, Emory University School of Medicine, Woodruff Memorial Building, Suite 6000, PO Drawer V, 1639 Pierce Drive, Atlanta, GA 30322, USA. thenr01@emory.edu
Thomas R
TR
Henry
John R
JR
Votaw
D001921:Brain / Q000000981:diagnostic imaging*; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging*; D004829:Epilepsy, Generalized / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18