Invasive Streptococcus pneumoniae in France: antimicrobial resistance, serotype, and molecular epidemiology findings from a monthly national study in 2000 to 2002.
A study of 257 French invasive pneumococci isolated between 2000 and 2002 showed high rates of nonsusceptibility to penicillin and macrolides (50%), contrasting with a low frequency of resistance to amoxicillin or levofloxacin (<1%) and tolerance to vancomycin (0%). The genetic homogeneity of some serogroups, including serogroup 1, enhanced the risk of epidemiological changes.
Centre Hospitalier de Versailles André Mignot, Service d'Hygiène Hospitalière, 177 rue de Versailles, 78157 Le Chesnay Cedex, France. JWDECOUSSER@ch-versailles.fr
Jean-Winoc
JW
Decousser
Patrick
P
Pina
Florent
F
Viguier
Franc
F
Picot
Patrice
P
Courvalin
Pierre
P
Allouch
D000328:Adult; D000658:Amoxicillin / Q000494:pharmacology; D002648:Child; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005602:France / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D011159:Population Surveillance; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
D000658:Amoxicillin