Comparison of parameters from rhythmometric models with multiple components on hybrid data.
Population multiple components is a statistical tool useful for the analysis of time-dependent hybrid data. With a small number of parameters, it is possible to model and to predict the periodic behavior of a population. In this article, we propose two methods to compare among populations rhythmometric parameters obtained by multiple component analysis. The first is a parametric method based in the usual statistical techniques for comparison of mean vectors in multivariate normal populations. The method, through MANOVA analysis, allows comparison of the MESOR and amplitude-acrophase pair of each component among two or more populations. The second is a nonparametric method, based in bootstrap techniques, to compare parameters from two populations. This test allows one to compare the MESOR, the amplitude, and the acrophase of each fitted component, as well as the global amplitude, orthophase, and bathyphase estimated when all fitted components are harmonics of a fundamental period. The idea is to calculate a confidence interval for the difference of the parameters of interest. If this interval does not contain zero, it can be concluded that the parameters from the two models are different with high probability. An estimation of p-value for the corresponding test can also be calculated. Both methods are illustrated with an example, based on clinical data. The nonparametric test can also be applied to paired data, a special situation of great interest in practice. By the use of similar bootstrap techniques, we illustrate how to construct confidence intervals for any rhythmometric parameter estimated from population multiple components models, including the orthophase, bathyphase, and global amplitude. These tests for comparison of parameters among populations are a needed tool when modeling the nonsinusoidal rhythmic behavior of hybrid data by population multiple component analysis.
Fernández
José R
JR
Bioengineering and Chronobiology Labs, ETSI Telecomunicación, University of Vigo, Campus Universitario, Vigo, Spain. jramon@tsc.uvigo.es
Mojón
Artemio
A
Hermida
Ramón C
RC
D002909:Chronobiology Phenomena; D002940:Circadian Rhythm / Q000502:physiology; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D018709:Statistics, Nonparametric; D013599:Systole / Q000502:physiology