Treatment of vancomycin-intermediate Staphylcoccus aureus endocarditis with linezolid.
We report a case of infective endocarditis due to vancomycin-intermediate Staphylococcus aureus that developed after repeated courses of vancomycin. The patient had underlying end stage renal disease and dissecting aortic aneurysm with aortic graft and prosthetic aortic valve replacement. He responded to prolonged combination therapy with linezolid and amikacin without undergoing surgical intervention.
Leung
K T
KT
Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong, China.
Tong
M K H
MK
Siu
Y P
YP
Lam
C S
CS
Ng
H L
HL
Lee
H K
HK
D000081:Acetamides / Q000627:therapeutic use*; D000583:Amikacin / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D016896:Treatment Outcome; D014640:Vancomycin / Q000494:pharmacology*
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000583:Amikacin; D000069349:Linezolid