Acute myocardial infarction in hemoglobin SC disease.
Although there are reports of myocardial infarction (MI) in patients with sickle cell diseases, an antemortem diagnosis of acute MI in a patient with compound heterozygous hemoglobin SC disease has not been reported. Herein, we present a patient with hemoglobin SC who suffered an acute MI. She had typical chest pain for myocardial ischemia, associated with ST elevations on the electrocardiogram (EKG) and elevations of cardiac injury markers diagnostic of infarction. The patient was treated with conventional therapies for acute coronary syndrome and also emergent red blood cell exchange. Interestingly, coronary angiography was completely normal in this patient. Potential mechanisms and management for acute MI in patients with sickle cell disease are discussed.
Wang
Henry
H
Division of Hematology and Oncology, Department of Medicine, Davis School of Medicine, University of California Davis Cancer Center, Sacramento, CA 95817, USA.
Laslett
Lawrence J
LJ
Richman
Carol M
CM
Wun
Ted
T
D000328:Adult; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006450:Hemoglobin SC Disease / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology*