Genomic segmental polymorphisms in inbred mouse strains.
By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.
Li
Jiangzhen
J
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Jiang
Tao
T
Mao
Jian-Hua
JH
Balmain
Allan
A
Peterson
Leif
L
Harris
Charles
C
Rao
Pulivarthi H
PH
Havlak
Paul
P
Gibbs
Richard
R
Cai
Wei-Wen
WW
D000818:Animals; D001483:Base Sequence; D022202:Chromosomes, Artificial, Bacterial; D018628:Gene Dosage; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011110:Polymorphism, Genetic