Chlamydia pneumoniae IgA seropositivity and sudden sensorineural hearing loss.
A prospective study was designed to evaluate a possible role of an endured infection with Chlamydia pneumoniae or Chlamydia trachomatis as a cause for sudden sensorineural hearing loss. For this in 60 patients with a first episode of a sensorineural hearing loss and-60 sex-matched and aged-matched controls, following a complete otoneurological diagnosis blood tests for IgA, IgM and IgG with regard to Chlamydia pneumoniae and trachomatis were evaluated. We found a statistically significant higher prevalence of IgA positivity of Chlamydia pneumoniae in patients with sudden sensorineural hearing loss (chi2-test, p < 0.017). For this, Chlamydia pneumoniae may be a possible cause for sudden sensorineural hearing loss. A targeted antibiotic therapy, as it has been discussed for myocardial infarction, might possibly open an additional treatment option for sudden sensorineural hearing loss.
Dünne
Anja A
AA
Department of Otorhinolaryngology, Head and Neck Surgery, Philipps-University, Marburg.
Wiegand
Anette
A
Prinz
Helge
H
Slenczka
W
W
Werner
Jochen A
JA
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002692:Chlamydia trachomatis / Q000276:immunology*; D023521:Chlamydophila Infections / Q000150:complications* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D005260:Female; D005858:Germany; D006319:Hearing Loss, Sensorineural / Q000382:microbiology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M