Intercontinental spread of pyrimethamine-resistant malaria.
Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. cally.roper@lshtm.ac.uk
Cally
C
Roper
Richard
R
Pearce
Shalini
S
Nair
Brian
B
Sharp
François
F
Nosten
Tim
T
Anderson
D000349:Africa; D000483:Alleles; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D001210:Asia, Southeastern; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance / Q000235:genetics; D004359:Drug Therapy, Combination; D019143:Evolution, Molecular; D017125:Genes, Protozoan; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology* / Q000517:prevention & control; D018895:Microsatellite Repeats; D009154:Mutation; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D011739:Pyrimethamine / Q000494:pharmacology* / Q000627:therapeutic use; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*
D000962:Antimalarials; D002738:Chloroquine; D013762:Tetrahydrofolate Dehydrogenase; D011739:Pyrimethamine