[The condition of the oxidant-antioxidant system of plasma and of blood erythrocytes in patients with severe renal insufficiency, anuria stage, due to compression trauma].
The lipid peroxidation processes as well as the activity of the antioxidant system of plasma and of blood erythrocytes were analyzed in severe renal insufficiency due to acute compression trauma. The levels of diene conjugates, malonic dialdehyde and shiff bases were found to be reliably higher in plasma in the anuria stage; as for erythrocytes, only the level of the final peroxidation products, i.e. shiff bases, turned out to be higher in their case. The antioxidant system reaction was as follows: a reliable decrease of the ceruplasmin level was registered in blood plasma, and a reduced activity of superoxide dismutase was detected in erythrocytes. No changed catalase activity was registered either in plasma or erythrocytes versus the controls. The occurred lipid-peroxidation activation had, in the erythrocyte membranes, a negative effect on the protein-lipid contact zones. According to the obtained results, it is necessary to use antioxidants and activation of the non-enzyme system within the complex therapy for the purpose of preventing the secondary damage to cellular membranes.
A V
AV
Tarakanov
L V
LV
Klimov
N N
NN
Usalev
D058186:Acute Kidney Injury / Q000097:blood* / Q000209:etiology; D000975:Antioxidants / Q000378:metabolism*; D001002:Anuria / Q000097:blood* / Q000209:etiology; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000378:metabolism; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D016877:Oxidants / Q000097:blood; D010084:Oxidation-Reduction; D014947:Wounds and Injuries / Q000150:complications*
D000975:Antioxidants; D016877:Oxidants