Reinforcing and subjective effects of methylphenidate: dose and time in bed.
So that reinforcing and subjective effects of methylphenidate as a function of dose and level of sleepiness could be evaluated, 21 volunteers received methylphenidate (5, 10, or 20 mg) or placebo on 2 sampling days. After 4 and 8 hr time in bed (TIB), they chose their preferred capsule on 5 days. Methylphenidate was chosen more frequently after 4 hr TIB (60%) than it was after 8 hr TIB (33%). The strongest preference (68%) was seen in the 10-mg group. At 10 and 20 mg, stimulant-like subjective effects were reported. The 10-mg group was more adversely affected by the restricted bedtime and showed more pronounced drug effects with methylphenidate. These results indicate that sleepiness modulates the reinforcing and subjective effects of methylphenidate.
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA. TARoehrs@aol.com
Timothy
T
Roehrs
Chris Ellyn
CE
Johanson
Renata
R
Meixner
Lauren
L
Turner
Thomas
T
Roth
D000328:Adult; D001143:Arousal / Q000187:drug effects; D001513:Beds; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D002755:Choice Behavior / Q000187:drug effects; D003710:Demography; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage*; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010147:Pain Measurement / Q000379:methods; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D000697:Central Nervous System Stimulants; D008774:Methylphenidate