Engineering of non-natural receptors.
Rational design, usually guided by computational prediction, and selection from libraries of variants of natural proteins have been used with success in the engineering of novel non-natural receptors. Many of these engineered protein binders will find use in biotechnological, diagnostic and medical applications, sometimes in the place of natural antibodies.
Laboratoire de Biochimie Physique et des Biopolymères, Institut des Sciences de la Vie, place Louis Pasteur 1, B1348 Louvain-la-Neuve, Belgium.
Pascale
P
Mathonet
Jacques
J
Fastrez
D001665:Binding Sites; D015374:Biosensing Techniques; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D017076:Computer-Aided Design; D008958:Models, Molecular; D015202:Protein Engineering / Q000379:methods*; D013329:Structure-Activity Relationship
D002352:Carrier Proteins