Renal effects of norepinephrine in septic and nonseptic patients.
OBJECTIVE
To assess the effects of a norepinephrine-induced vasoconstriction on renal function in septic and nonseptic patients.


METHODS
Open-label prospective study.


METHODS
Medical-surgical ICU in an urban teaching hospital.


METHODS
Fourteen patients with septic shock and 12 uninfected patients with head trauma (Glasgow coma score, < 8).


METHODS
Patients received norepinephrine infusion to increase systemic vascular resistance index (SVRI), and to raise mean arterial BP (MAP) to > 70 mm Hg in the septic group and cerebral perfusion pressure (CPP) to > 70 mm Hg in the head trauma group.


RESULTS
MAP and SVRI increased in both groups (p < 0.001), and CPP significantly increased in the head trauma group (p < 0.001). The cardiac index was not modified in either group. Norepinephrine infusion reestablished urine flow in 12 of the 14 septic patients (p < 0.001), with a decrease in serum creatinine levels (p < 0.001) and an increase in creatinine clearance rate (p < 0.001) after 24 h. Urine parameters were not affected in the head trauma group.


CONCLUSIONS
Within the limitation of the present study, norepinephrine administration induces a marked vasoconstriction in septic and nonseptic patients. Norepinephrine has positive effects on renal function in septic patients but has no significant effect on the same urinary parameters when administered to uninfected patients with normal renal function.
Department of Anesthesiology and Intensive Care Medicine and Trauma Center, Marseilles University Hospital System, Marseilles School of Medicine, France.
Jacques
J
Albanèse
Marc
M
Leone
Franck
F
Garnier
Aurélie
A
Bourgoin
François
F
Antonini
Claude
C
Martin
D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D006259:Craniocerebral Trauma / Q000503:physiopathology; D003401:Creatine / Q000097:blood; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies; D012772:Shock, Septic / Q000503:physiopathology*; D014563:Urodynamics / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D003401:Creatine; D009638:Norepinephrine