Evaluation of a new method for calculation of cumulative doses in the rectum wall using repeat CT scans.
The rectum wall is an important organ at risk during irradiation of the prostate, the bladder and other organs in the pelvis. It is therefore of great interest to be able reliably to predict normal tissue complication probabilities (NTCPs) for this organ. Because the rectum wall is a hollow organ capable of large deformations between fractions, dose estimates from a single CT are unreliable, and thereby also NTCP estimates. In this study two methods for calculations of cumulative dose distributions from repetitive CT scans are compared. The first is a method presented in this article that uses tracking of volume elements for a direct summation of the doses delivered in the treatment fractions. The other, presented earlier (1), is based on information from dose-volume histograms. The comparisons were made in terms of equivalent uniform doses (EUDs) and NTCPs. The methods were also compared with mean values of EUD and NTCP values from individual CT scans. The study showed that with the relatively symmetric beam arrangements normally used for treatment of prostate and bladder cancer, it is not necessary to use the more laborious method of element tracking. However, an introduction of artificial lateral rectum movements revealed that element tracking is necessary in less symmetric situations.
Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway. ykvi@helse-bergen.no
Yngve
Y
Kvinnsland
Ludvig Paul
LP
Muren
Olav
O
Dahl
D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000532:radiotherapy; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy; D011832:Radiation Injuries / Q000517:prevention & control; D011834:Radiation Monitoring / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods; D012007:Rectum / Q000000981:diagnostic imaging* / Q000528:radiation effects*; D018570:Risk Assessment; D012494:Sampling Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000532:radiotherapy