Studies on catalytic asymmetric Nozaki-Hiyama propargylation.
Catalytic asymmetric Nozaki-Hiyama propargylation with ligand 1c proceeds with good to excellent enantioselectivity. Tuning of ligand 1 dramatically changes the enantioselectivity, and we propose models A and B to explain the change and outcome of the enantioselectivity.
Inoue
Masahiro
M
Department of Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Nakada
Masahisa
M