Pharmacogenetics.
This article provides an introduction to the discipline of pharmacogenetics and discusses the implications of pharmacogenetics research for primary care practice. Examples are given of how genetic information can predict and inform; drug interactions influencing drug efficacy, metabolism, dosing, and toxicity. Caveats on the need for vigilance in the interpretation of pharmacogenetics studies are discussed briefly, together with the need for a convergence of biomolecular research, translational research, education,and policy to promote evidence-based genetic medicine.
David
Sean P
SP
Department of Family Medicine, Brown Medical School, Brown University Center for Primary Care and Prevention, Primary Care Genetics Laboratory, Translational Research Center, Memorial Hospital of Rhode Island USA. Sean_David@brown.edu
D015195:Drug Design; D004347:Drug Interactions; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011320:Primary Health Care; D009626:Terminology as Topic; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000235:genetics