[Enhancement of efficiency in the chemotherapy of ovarian cancer].
As many as 308 patients with stage IV ovarian carcinoma (OC) were examined to assess effectiveness of employing platinum drugs (CP and CAP)-based chemotherapy regimens depending on the degree of differentiation of tumor cells, on the extent to which the process has been disseminated, and on the cytostatics regimens adopted. Standard chemotherapy regimens permitting maintaining the standard "intensity" of the cytostatic dose have been shown to improve OC treatment results, especially in those patients presenting with medium and high-grade (poorly differentiated) tumors. Patients with low-grade tumors derive benefit when placed on the above chemotherapy at 4 weeks intervals whereas those with medium- and high-grade tumors benefit from treatments on a 3-week interval schedule.
A S
AS
Dudnichenko
T P
TP
Iakimova
S M
SM
Kartashov
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D018572:Disease-Free Survival; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology