QT dispersion and electrical heart field morphology in patients treated with dosulepin.
The aim of the study was to detect the changes of QT dispersion (QTd) due to cardiotoxicity of tricyclic antidepressant dosulepin. Electrocardiographic and vectorcardiographic recordings were obtained using Cardiag 112.2 diagnostic system from 28 psychiatric outpatients treated with prophylactic doses of dosulepin and compared to those obtained from 37 healthy volunteers. From these recordings following parameters were evaluated: QTd, spatial QRS-STT angle and amplitude of T-wave. The acquired data were correlated with the dosulepin plasma levels using Spearman's rank order correlation test. The average QTd (+/-S.D.) in the dosulepin group was significantly higher (70+/-21 ms) than that in the control group (34+/-12 ms) (P<0.001). Moreover, the correlation between QTd and the dosulepin plasma levels was highly significant (r = 0.7871, P<0.001). Similar results were obtained when QTc dispersion was used. On the contrary, the QRS-STT space angle did not correlate with the dosulepin plasma levels. Furthermore, the T-wave amplitude was not significantly correlated to the QT-interval. Thus we can conclude that the QT dispersion could be used as a simple marker of the dosulepin effect on the myocardium.
Institute of Physiology, First Medical Faculty, Charles University, Albertov 5, 128 00 Prague 2, Czech Republic. okittnar@lf1.cuni.cz
O
O
Kittnar
I
I
Paclt
M
M
Mlcek
J
J
Slavícek
A
A
Dohnalová
S
S
Havránek
E
E
Brizman
E
E
Kitzlerová
K
K
Pisvejcová
D000328:Adult; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy; D004308:Dothiepin / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008133:Long QT Syndrome / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D004308:Dothiepin