Inhibitory effect of capsaicin evoked trigeminal pain on warmth sensation and warmth evoked potentials.
The aim of the study was to evaluate the effect of tonic pain evoked by topical application of capsaicin on the somatosensory sensation of warmth. The warmth pathways were studied in ten healthy subjects by recording the scalp potentials evoked by non-painful warm laser stimuli delivered on both the right and left perioral region (warmth C-fiber related laser-evoked potentials (C-LEPs)). Tonic pain was induced by topical capsaicin application above the lateral part of the right upper lip. The area of primary and secondary hyperalgesia were mapped. C-LEPs were obtained from 31 scalp electrodes before, during, and after capsaicin application. C-LEPs from the right perioral region were evoked by laser stimuli delivered to the area of secondary hyperalgesia during capsaicin application and on both the areas of primary and secondary hyperalgesia after capsaicin removal. While the lateralized N1/P1 component (around 185 ms of latency) was not affected by the capsaicin, the amplitudes of the later vertex C-LEPs (around 260 and 410 ms of latency for the N2a and P2 potentials, respectively) evoked from the secondary hyperalgesic area on the right side and from a symmetrical non-hyperalgesic area on the left perioral region were significantly decreased during capsaicin application and after capsaicin removal, as compared with the baseline recordings. At the same times, the rating of the laser-evoked warmth sensation was reduced significantly. This inhibitory effect can occur at brainstem level and is possibly due to: 1) trigemino-cortico-trigeminal circuits, similar to those mediating the classical diffuse noxious inhibitory control, or 2) an increased background activity of the capsaicin-insensitive A-fibers, which mediate the secondary hyperalgesia. Probably due to a peripheral inhibitory mechanism, neither reliable C-LEP components nor warmth sensation were evoked by laser pulses delivered to the primary hyperalgesic area. This is the first neurophysiological evidence in humans of an inhibitory effect of pain on warmth sensation.
Divisione di Neurologia, Ospedale Pediatrico Bambino Gesů, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. m.valeriani@tiscali.it
Massimiliano
M
Valeriani
Michele
M
Tinazzi
Domenica
D
Le Pera
Domenico
D
Restuccia
Liala
L
De Armas
Toni
T
Maiese
Pietro
P
Tonali
Lars
L
Arendt-Nielsen
D000328:Adult; D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000502:physiology; D002211:Capsaicin; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D036421:Nerve Fibers, Unmyelinated / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013697:Thermosensing / Q000502:physiology*; D014276:Trigeminal Nerve / Q000187:drug effects / Q000502:physiology*
D002211:Capsaicin