[Pharmacological study on "zishen huayu fang" on treatment of mesangial proliferative glomerulonephritis in rats].
OBJECTIVE
To explore the effects and the mechanisms of "zishen huayu fang" (ZSHYF) on treatment of mesangial proliferative glomerulonephritis (MPG) in rats.


METHODS
The rat model of MPG was induced by injecting anti-thymocyte serum (ATS) through caudal vein. The effects of ZSHYF on renal function and morphology were studied.


RESULTS
ZSHYF can remarkably reduce urine protein, urine red blood cell and serum levels of BUN and Scr, increase serum albumin content, decrease immune complex IgG and C3 under epithelial cells of glomerulus capillary and alleviate the pathological injury in MPG rats.


CONCLUSIONS
ZSHYF can lessen pathological changes of glomerulus and stramo in MPG rats, stabilize and ameliorate their renal function.
Xiaohua
Wang
W
Guangzhou Medical College, Guangzhou 510182.
Qingfeng
Jiang
J
Hongzhu
Deng
D
Wei
Xiao
X
D000818:Animals; D001806:Blood Urea Nitrogen; D001809:Blood Viscosity / Q000187:drug effects; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D011507:Proteinuria / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012709:Serum Albumin