Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats.
We studied the involvement of hippocampal protein synthesis-, PKA-, and MAP kinase-dependent processes in short- (STM) and long-term memory (LTM) for inhibitory avoidance task. Fifteen minutes before or immediately after training rats received intrahippocampal infusions of vehicle, the protein synthesis inhibitor anisomycin, the PKA inhibitor Rp-cAMPs or the MAPKK inhibitor PD098059. The results show that STM recruits PKA and MAPK, whereas, LTM depends on PKA activity and protein synthesis during the early post-training period.
Laboratório de Neurotoxicologia, Universidade do Extremo Sul Catarinense, Av. Universitaria 1105, Criciúma 88806-000, SC, Brazil. quevedo1@terra.com.br
João
J
Quevedo
Mônica R M
MR
Vianna
Márcio Rodrigo
MR
Martins
Tatiana
T
Barichello
Jorge H
JH
Medina
Rafael
R
Roesler
Ivan
I
Izquierdo
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008568:Memory / Q000145:classification* / Q000187:drug effects / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D018709:Statistics, Nonparametric; D013997:Time Factors
D004791:Enzyme Inhibitors; D011506:Proteins; D017868:Cyclic AMP-Dependent Protein Kinases; D020928:Mitogen-Activated Protein Kinases