Prognostic factors for survival of dogs with inguinal and perineal mast cell tumors treated surgically with or without adjunctive treatment: 68 cases (1994-2002).
OBJECTIVE
To determine the prognostic factors for survival and tumor recurrence in dogs with cutaneous mast cell tumors (MCTs) in the perineal and inguinal regions treated surgically with or without adjunctive radiation therapy, chemotherapy, or both.


METHODS
Retrospective study.


METHODS
68 dogs.


METHODS
Medical records of dogs with histologically confirmed MCTs in the perineal region, inguinal region, or both treated surgically with or without adjunctive radiation therapy, chemotherapy, or both were reviewed.


RESULTS
Mean tumor-free interval was 1,635 days (median not reached), and 1- and 2-year tumor-free rates were 79% and 71%, respectively. Median survival time was 1,111 days (mean, 1,223 days), and 1- and 2-year survival rates were 79% and 61%, respectively. Factors that negatively influenced survival time were age at diagnosis, tumor recurrence, and treatment with lomustine.


CONCLUSIONS
Results indicated that dogs with MCTs in the inguinal and perineal regions, if appropriately treated, may have survival times and tumor-free intervals similar to dogs with MCTs in other locations.
Harrington Oncology Program, Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
Alane Kosanovich
AK
Cahalane
Sarah
S
Payne
Lisa G
LG
Barber
Lillian E
LE
Duda
Carolyn J
CJ
Henry
Glenna E
GE
Mauldin
Angela E
AE
Frimberger
Susan M
SM
Cotter
Antony S
AS
Moore
D000818:Animals; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000401:mortality* / Q000601:surgery; D004285:Dogs; D005260:Female; D006119:Groin; D008297:Male; D012515:Mast-Cell Sarcoma / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D010502:Perineum; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000662:veterinary; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D013997:Time Factors; D016896:Treatment Outcome