Morphologic and biomechanical changes of rat oesophagus in experimental diabetes.
OBJECTIVE
To study morphologic and biomechanical changes of oesophagus in diabetes rats.


METHODS
Diabetes was induced by a single injection of streptozotocin (STZ). The type of diabetes mellitus induced by parenteral STZ administration in rats was insulin-dependent (type I). The samples were excised and studied in vitro using a self-developed biomaterial test machine.


RESULTS
The body mass was decreased after 4 d with STZ treatment. The length of esophagus shortened after 4, 7, 14 d. The opening angle increased after 14 d. The shear, longitudinal and circumferential stiffness were obviously raised after 28 d of STZ treatment.


CONCLUSIONS
The changes of passive biomechanical properties reflect intra-structural alteration of tissue to a certain extent. This alteration will lead to some dysfunction of movement. For example, tension of esophageal wall will change due to some obstructive disease.
Forensic Medicine Department, Medical College, Shantou University, Shantou 515031, Guangdong Province, China. yjzeng@bjut.edu.cn
Yan-Jun
YJ
Zeng
Jian
J
Yang
Jing-Bo
JB
Zhao
Dong-Hua
DH
Liao
En-Ping
EP
Zhang
Hans
H
Gregersen
Xiao-Hu
XH
Xu
Hong
H
Xu
Chuan-Qing
CQ
Xu
D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D015154:Esophageal Motility Disorders / Q000209:etiology / Q000503:physiopathology*; D004947:Esophagus / Q000503:physiopathology*; D009092:Mucous Membrane / Q000503:physiopathology; D009130:Muscle, Smooth / Q000503:physiopathology; D051381:Rats; D013314:Stress, Mechanical