BNCT of 3 cases of spontaneous head and neck cancer in feline patients.
Having demonstrated BPA-BNCT induced control of experimental squamous cell carcinomas (SCC) of the hamster cheek pouch mucosa with no damage to normal tissue we explored the feasibility and safety of treating spontaneous head and neck tumors, with particular focus on SCC, of terminal feline patients with low dose BPA-BNCT employing the thermal beam of the RA-1 Reactor within a preclinical context. The biodistribution studies showed that, in all three cases evaluated, BPA delivered absolute boron values to tumor in the range that proved therapeutically useful in the experimental model of SCC. BPA-BNCT studies showed no radiotoxic effects, partial tumor control in terms of impaired growth and partial necrosis, an improvement in clinical condition and prolonged survival beyond the terminal condition of the feline patients at the time of recruitment.
Rao
Mónica
M
Veterinary Oncology Center, Avenida del Libertador 15013, (1642) Acassuso, Prov. Buenos Aires, Argentina.
Trivillin
Verónica A
VA
Heber
Elisa M
EM
Cantarelli
María de los Angeles
Mde L
Itoiz
María E
ME
Nigg
David W
DW
Rebagliati
Raúl Jiménez
RJ
Batistoni
Daniel
D
Schwint
Amanda E
AE
D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000662:veterinary*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D002371:Cat Diseases / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D002415:Cats; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution
C436045:4-dihydroxyborylphenylalanine; D001896:Boron Compounds; D010649:Phenylalanine