Is leptin associated with serum lipid profile or any other parameters of blood biochemistry in post-menopausal women with osteoporosis?
We investigated the relationship between serum leptin concentration, serum lipid profile and other blood biochemistry parameters in healthy post-menopausal women. Blood samples for analysis of serum leptin concentration, blood biochemistry and hormonal status, and urine samples for calcium measurement were taken from 122 women. No significant correlation was found between serum leptin concentration and serum lipid profile. The concentration of serum leptin was significantly associated with body mass index (BMI), luteinizing hormone (LH) and alanine transaminase (ALT). BMI was found to be a statistically significant independent factor for serum leptin concentration. We conclude that leptin was not associated with serum lipids and lipoproteins in post-menopausal women. Leptin was associated with BMI, ALT and LH, however, with BMI being an independent predictor of leptin concentration. There was a relationship between LH and serum leptin concentration even after menopause, and ALT correlated with serum leptin concentration through BMI.
Oguz
S
S
Department of Obstetrics and Gynecology, Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Aytan
H
H
Tapisiz
O L
OL
Günyeli
I
I
Erdem
S
S
Tuncay
G
G
Mollamahmutoglu
L
L
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D015992:Body Mass Index; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D020738:Leptin / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood*; D017698:Postmenopause; D012044:Regression Analysis; D013997:Time Factors
D020738:Leptin; D008055:Lipids; D007986:Luteinizing Hormone; D000410:Alanine Transaminase; D002118:Calcium