Improving catalyst scope: use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization.
[reaction: see text] Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization-trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.
Takacs
James M
JM
Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA. jtakacs1@unl.edu
Han
Jianxin
J
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000475:Alkenes; D000814:Aniline Compounds; D010165:Palladium