[Indirect relation between intimo-medial thickness of the carotid artery and vasodilation of the popliteal artery].
BACKGROUND
Intima-media thickness of the common carotid artery (IMT ACC) and flow-mediated vasodilatation (FMD) of the brachial artery is considered an early marker of atherosclerosis. This study was undertaken to elucidate whether endothelial dysfunction in the popliteal artery, pronoun to atherosclerosis, is related to IMT ACC.


RESULTS
Twenty-nine control subjects, 29 asymptomatic patients with hyperlipoproteinemia (without therapy) and 26 patients with coronary artery disease were examined. Using ultrasound with a linear-array probe (7.5 MHz), we measured IMT ACC and diameter of the popliteal artery (PA) at rest and during reactive hyperaemia after release of 5-minute arterial occlusion. In control subjects we found thicker IMT ACC and greater FMD than did the patients (p<0.001, ANOVA test). A significant negative correlation between the IMT ACC and percent FMD was found in all of the subjects (p<0.001). On multiple regression analysis, percent FMD showed a significant negative correlation with the IMT ACC, total cholesterol, triacylglyceroles, body mass index, age, and diastolic blood pressure.


CONCLUSIONS
We found significant negative correlation between IMT common carotid artery and FMD popliteal artery.
III. interní klinika 1, lékarské fakulty Univerzity Karlovy a Vseobecné fakultní nemocnice v Praze.
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D000328:Adult; D001161:Arteriosclerosis / Q000473:pathology / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000033:anatomy & histology / Q000473:pathology*; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006951:Hyperlipoproteinemias / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D011150:Popliteal Artery / Q000502:physiology / Q000503:physiopathology*; D017539:Tunica Intima / Q000033:anatomy & histology / Q000473:pathology; D017540:Tunica Media / Q000033:anatomy & histology / Q000473:pathology; D014664:Vasodilation