Genomic segmental polymorphisms in inbred mouse strains.
By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Jiangzhen
J
Li
Tao
T
Jiang
Jian-Hua
JH
Mao
Allan
A
Balmain
Leif
L
Peterson
Charles
C
Harris
Pulivarthi H
PH
Rao
Paul
P
Havlak
Richard
R
Gibbs
Wei-Wen
WW
Cai
D000818:Animals; D001483:Base Sequence; D022202:Chromosomes, Artificial, Bacterial; D018628:Gene Dosage; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011110:Polymorphism, Genetic