A concise total synthesis of (+)-okaramine C.
The first total synthesis of (+)-okaramine C is described. Our previously described selenocyclisation-oxidative deselenation sequence was used to establish a 3a-hydroxy-pyrrolo[2,3-b]indole core, which was modified by selective epimerisation to the common pyrrolo[2,3-b]indole of the okaramines.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
Peter R
PR
Hewitt
Ed
E
Cleator
Steven V
SV
Ley
D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation
D026121:Indole Alkaloids; C501539:okaramine C; C501540:okaramine J