Resistin levels in patients with obstructive sleep apnoea syndrome--the link to subclinical inflammation?
BACKGROUND
The role of resistin, a "new" white adipose tissue hormone, still needs to be established. Its linkage to insulin sensitivity and body mass was controversial in previous studies.


METHODS
Twenty obese patients (BMI: 32.1+/-6.9 kg/m2 ) with obstructive sleep apnoea syndrome (OSAS) (Apnoea-Hypopnoea Index: 48.6+/-19.1, underwent measurements of resistin, interleukin-6 (IL-6), intracellular adhesion molecule-1 (ICAM-1), CRP and the insulin sensitivity index (ISI) by hyperinsulinaemic euglycaemic clamp before, 2 days and 2 months after onset of CPAP treatment.


RESULTS
Resistin remained unchanged during CPAP-therapy and was negatively correlated to ISI (r=-0.359; p=0.006), the latter was significantly improved by CPAP (p<0.001). In a correlation matrix, IL-6 and ICAM-1 were significantly (p=0.001) correlated to resistin (p=0.614 and 0.427). Changes of inflammatory markers under CPAP treatment were related to AHI, as well as resistin changes.


CONCLUSIONS
In agreement with previous investigations, we could only demonstrate a weak linkage between ISI and resistin. However, at least in obese patients with OSAS, there is a close relation to subclinical inflammation (IL-6) and endothelial activation (ICAM-1).
Division of Respiratory Medicine, Medical Department I, Friedrich-Alexander University of Erlangen-Nuremberg, D-91054 Erlangen, Germany. igor.harsch@med1.imed.uni-erlangen.de
Igor Alexander
IA
Harsch
Corinna
C
Koebnick
Henri
H
Wallaschofski
Simin Pour
SP
Schahin
Eckhart Georg
EG
Hahn
Joachim Hans
JH
Ficker
Tobias
T
Lohmann
Peter Christopher
PC
Konturek
D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D045422:Continuous Positive Airway Pressure; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism; D010349:Patient Compliance; D017286:Polysomnography; D052243:Resistin; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D013223:Statistics as Topic
D006729:Hormones, Ectopic; D015850:Interleukin-6; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein