[Adverse events of inhaled steroids in childhood].
The adverse events of the inhaled steroids on growth and bone mineralization concern the pediatricians. From the available current data, we exposed the following conclusions: 1) Inhaled steroids must be preferred to oral steroids; 2) Short, middle and long-term adverse effects of inhaled steroids have to be differentiated. Only the long-term effects reflect possible sequela; 3) The adverse effects are specific from the considered inhaled steroids, the most recent available drugs having less adverse effects on bone and growth; 4) Recent data did not show consequences on the adult height and bone mineralization; 5) Recommendations in the use of inhaled steroids must be known by the practitioners in order to limit the adverse events of these drugs. Growth need to be surveyed in children with inhaled steroids and more studies are still necessary. In addition, we enhanced that local adverse effects should be sought by the physicians. Cough after inhalation was frequent and might be a negative factor of compliance.
Unité de pneumologie et allergologie pédiatrique, hôpital Charles-Nicolle, CHU, 76031 Rouen cedex, France. christophe.marguet@chu-rouen.fr
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D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy; D001842:Bone and Bones / Q000187:drug effects; D002648:Child; D003371:Cough / Q000209:etiology; D006128:Growth / Q000187:drug effects; D006801:Humans
D000305:Adrenal Cortex Hormones