Parameters of the attenuated schistosome vaccine evaluated in the olive baboon.
Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.
Kariuki
Thomas M
TM
Institute of Primate Research, Karen, Nairobi, Kenya.
Farah
Idle O
IO
Yole
Dorcas S
DS
Mwenda
Jason M
JM
Van Dam
Govert J
GJ
Deelder
André M
AM
Wilson
R Alan
RA
Coulson
Patricia S
PS
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D006801:Humans; D010215:Papio; D010270:Parasite Egg Count; D012547:Schistosoma / Q000276:immunology* / Q000302:isolation & purification; D012552:Schistosomiasis / Q000276:immunology / Q000469:parasitology* / Q000517:prevention & control*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000276:immunology*
D000909:Antibodies, Helminth; D014613:Vaccines, Attenuated