Heat shock protein 27 protects the heart against myocardial infarction.
Heat shock proteins (hsp) represent a group of chaperones which protects the cells against a diversity of stresses. It has been demonstrated that hsp27 is constitutively present in cells where it plays an important role in different cytoprotective processes which ultimately inhibit cell death. We investigated the response of the isolated perfused mouse heart over expressing hsp27 to the ischaemia/reperfusion injury using infarct size as an end point. Our results show for the first time that mice over expressing hsp27 (verified by Western blotting analysis) were found to be protected from lethal ischaemia/reperfusion injury compared to their negative littermates.
The Hatter Institute and Centre for Cardiology, Universitiy College London Hospitals and Medical School London, Grafton Way, London WC1E 6DB, UK.
Christopher A
CA
Efthymiou
Mihaela M
MM
Mocanu
Jackie
J
de Belleroche
Dominic J
DJ
Wells
David S
DS
Latchmann
Derek M
DM
Yellon
D000818:Animals; D005260:Female; D015870:Gene Expression; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology*; D015428:Myocardial Reperfusion Injury
D006360:Heat-Shock Proteins