Use of the caudolateral curvilinear osteophyte as an early marker for future development of osteoarthritis associated with hip dysplasia in dogs.
OBJECTIVE
To determine the relationship between the caudolateral curvilinear osteophyte (CCO) and osteoarthritis associated with hip dysplasia in dogs.


METHODS
Longitudinal cohort study.


METHODS
48 Labrador Retrievers from 7 litters.


METHODS
In each of 24 sex- and size-matched pairs fed the same diet, a restricted-fed dog was fed 25% less than a control dog for life. The dogs' hips were evaluated in the standard ventrodorsal hip-extended radiographic projection at 16, 30, and 52 weeks of age and then yearly for life. Histologic examination of hip joint tissues was performed on 45 dogs.


RESULTS
Median age at death was 11.2 years. Adjusting for feeding group, dogs with a CCO were 3.7 times as likely to develop radiographic signs of osteoarthritis than those without a CCO. Stratified by diet, 100% of the control dogs with a CCO developed radiographic signs of osteoarthritis and 55% of restricted-fed dogs with a CCO developed radiographic signs of osteoarthritis. The CCO was the first radiographic change seen in 22 of 29 (76%) dogs with osteoarthritis. Overall, 35 of 37 (95%) dogs with a CCO had histopathologic lesions of osteoarthritis.


CONCLUSIONS
Results indicate a relationship between a CCO on the femoral neck and subsequent development of radiographic signs of osteoarthritis in Labrador Retrievers evaluated over their life span. A CCO is an important early radiographic indication of osteoarthritis associated with canine hip dysplasia.
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
Michelle Y
MY
Powers
Daryl N
DN
Biery
Dennis E
DE
Lawler
Richard H
RH
Evans
Frances S
FS
Shofer
Philipp
P
Mayhew
Thomas P
TP
Gregor
Richard D
RD
Kealy
Gail K
GK
Smith
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D015415:Biomarkers; D001835:Body Weight / Q000502:physiology*; D015331:Cohort Studies; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D004285:Dogs; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D005508:Food Deprivation / Q000502:physiology*; D006619:Hip Dysplasia, Canine / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000662:veterinary; D008137:Longitudinal Studies; D008297:Male; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D011859:Radiography; D011897:Random Allocation; D012307:Risk Factors
D015415:Biomarkers