Indinavir increases glucose production in healthy HIV-negative men.
In the absence of HIV infection, changes in adipose tissue and lipid levels, HIV protease inhibitor therapy increases fasting glucose levels,suggestive of hepatic insulin resistance. After 4 weeks of indinavir treatment in nine HIV-negative healthy men, fasting glucose production and glycogenolysis were significantly increased. During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production. Therefore, indinavir worsens hepatic insulin sensitivity, increasing endogenous glucose production.
Department of Medicine, University of California, San Francisco, CA, USA.
Jean-Marc
JM
Schwarz
Grace A
GA
Lee
Seongsoo
S
Park
Mustafa A
MA
Noor
Jeongae
J
Lee
Michael
M
Wen
Joan C
JC
Lo
Kathleen
K
Mulligan
Morris
M
Schambelan
Carl
C
Grunfeld
D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D005215:Fasting / Q000097:blood; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D006801:Humans; D019469:Indinavir / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D008297:Male
D001786:Blood Glucose; D017320:HIV Protease Inhibitors; D007328:Insulin; D019469:Indinavir