Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.
We studied one to four doses of meningococcal polysaccharides A and C conjugated to diphtheria toxoid (Men D) versus A/C polysaccharide (Men PS) vaccine in 618 infants in Niger. Men PS at 24 months permitted evaluating memory. Two Men D doses (at 3 and 9 months) induced higher serum bactericidal activity (SBA) than other regimens. SBA titers after Men PS at 24 months were higher in those given Men D in infancy versus Men PS. While responses were lower for serogroup C, hyporesponsiveness was not evident. Men D was well-tolerated. A single Men D dose in infancy appeared to induce memory.
CERMES, B.P. 10887, Niamey, Niger. chippaux@ird.sn
J-P
JP
Chippaux
A
A
Garba
C
C
Ethevenaux
G
G
Campagne
F
F
de Chabalier
S
S
Djibo
P
P
Nicolas
H
H
Ali
M
M
Charrondière
R
R
Ryall
M
M
Bybel
A
A
Schuchat
D001770:Blood Bactericidal Activity; D004168:Diphtheria Toxoid / Q000009:adverse effects / Q000276:immunology*; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007156:Immunologic Memory / Q000276:immunology*; D007223:Infant; D008297:Male; D008585:Meningitis, Meningococcal / Q000453:epidemiology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000009:adverse effects / Q000276:immunology*; D009305:Nasopharynx / Q000276:immunology; D009548:Niger / Q000453:epidemiology; D017778:Vaccines, Combined / Q000276:immunology; D018074:Vaccines, Conjugate / Q000009:adverse effects / Q000276:immunology
D004168:Diphtheria Toxoid; D022401:Meningococcal Vaccines; D017778:Vaccines, Combined; D018074:Vaccines, Conjugate