Cumulative ongoing pregnancy rate in intracytoplasmic sperm injection cycles.
OBJECTIVE
We investigated the cumulative probability of ongoing pregnancy in intracytoplasmic sperm injection (ICSI) cycles.


METHODS
During a period of 6 years, 519 ICSI cycles were performed in 260 infertile couples at the Seoul National University Hospital. The cumulative rate of ongoing pregnancy (> or =12 weeks of gestation) was estimated by the Kaplan-Meier method.


RESULTS
The cumulative ongoing pregnancy rate was 54.9% after six consecutive cycles of ICSI. The age of the female had a significant impact; after five consecutive cycles, cumulative ongoing pregnancy rate was 61.8% in < or =30 years of age, 51.7% in 31-35, and 15.3% in > or =36. There was no significant difference in the cumulative ongoing pregnancy rate between groups with severe male factor and previous unexplained low fertilization rate (< or =20%). Among the severe male factor group, cumulative ongoing pregnancy rate was not different according to the methods of sperm retrieval (surgically retrieved or ejaculated).


CONCLUSIONS
Intracytoplasmic sperm injection could be applied successfully both to severe male factor and patients with previous unexplained low fertilization rate. The origin of spermatozoa does not affect ICSI outcome in terms of cumulative probability of ongoing pregnancy.
Department of Obstetrics and Gynecology, College of Medicine, and Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul 110-744, Korea.
Byung Chul
BC
Jee
Seung Yup
SY
Ku
Chang Suk
CS
Suh
Young Min
YM
Choi
Jung Gu
JG
Kim
Shin Yong
SY
Moon
Seok Hyun
SH
Kim
D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D018873:Pregnancy Rate; D011336:Probability; D020554:Sperm Injections, Intracytoplasmic