MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels.
MCP-1 levels are increased in CSF of patients with Alzheimer's disease (AD) compared with controls, suggesting a role in the development of dementia. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. The distribution of the A-2518G SNP was determined in 269 AD patients and in 203 healthy age matched controls, showing no differences between the two groups. On the contrary, a significant increase of MCP-1 serum levels in AD patients carrying at least one G mutated allele was observed. Moreover, the highest peaks of MCP-1 serum levels were present in patients carrying two G alleles. Stratifying by ApoE genotype, gender or age at onset, no differences in both allele frequency and MCP-1 serum concentration were observed. The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD.
Fenoglio
Chiara
C
Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.
Galimberti
Daniela
D
Lovati
Carlo
C
Guidi
Ilaria
I
Gatti
Alberto
A
Fogliarino
Sergio
S
Tiriticco
Marco
M
Mariani
Claudio
C
Forloni
Gianluigi
G
Pettenati
Carla
C
Baron
Pierluigi
P
Conti
Giancarlo
G
Bresolin
Nereo
N
Scarpini
Elio
E
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics* / Q000276:immunology; D018932:Chemokine CCL2 / Q000097:blood / Q000235:genetics*; D018925:Chemokines / Q000276:immunology; D002634:Chemotaxis, Leukocyte / Q000235:genetics* / Q000276:immunology; D004252:DNA Mutational Analysis; D004660:Encephalitis / Q000097:blood / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D015854:Up-Regulation / Q000235:genetics / Q000276:immunology
D018932:Chemokine CCL2; D018925:Chemokines