Pathophysiology of functional dyspepsia.
Functional dyspepsia is a highly prevalent symptom complex and a heterogeneous disorder. Recent studies showed potential associations between specific pathophysiologic disturbances and dyspeptic symptoms. Delayed gastric emptying reported in about 30% of patients with functional dyspepsia is associated with the symptoms of postprandial fullness, nausea, and vomiting. Impaired gastric accommodation present in 40% of functional dyspepsia patients is found to be associated with early satiety. Hypersensitivity to gastric distension is observed in 37% of functional dyspepsia patients and associated with the symptoms of postprandial pain, belching, and weight loss. Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms.
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Kwang-Jae
KJ
Lee
S
S
Kindt
Jan
J
Tack
D004415:Dyspepsia / Q000503:physiopathology*; D017615:Enteric Nervous System / Q000503:physiopathology; D004884:Eructation / Q000503:physiopathology; D005744:Gastric Acid / Q000378:metabolism; D005746:Gastric Emptying / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology; D016481:Helicobacter Infections / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans; D050356:Lipid Metabolism; D009325:Nausea / Q000503:physiopathology; D012527:Satiation / Q000502:physiology; D014839:Vomiting / Q000503:physiopathology