Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).
OBJECTIVE
To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.


METHODS
Four cases of essential hypertension patients (1 male and 3 females) were observed through process of therapy with indapamide and laboratory investigations.


RESULTS
After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses. After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.


CONCLUSIONS
Therapy with indapamide may induce diabetes in essential hypertension patients. After stopping indapamide, glucose tolerance impairing may be reversed.
Jian-Liang
Zhang
Z
Department of Cardiovasology, Changhai Hospital (J.L.Z., Y.W.Q., X.Z, J.L.Q., J.C., R.L.X.), 174 Changhai Road, Shanghai 200433, PR China. zhangjl2002@citiz.net
Yong-Wen
Qin
Q
Xing
Zheng
Z
Jian-Li
Qiu
Q
Jiang
Cao
C
Rong-Liang
Xu
X
D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D005260:Female; D017328:Fosinopril / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000959:Antihypertensive Agents; D001786:Blood Glucose; D007190:Indapamide; D017328:Fosinopril