Histological changes of white rat kidney after experimental administration of ethanol and cephalexin.
The experiment was carried out on Wistar rat males weighing about 200 g. Animals from the control group received water and standard granulated fodder ad libitum. Animals from control group II received 20% ethanol ad libitum instead of water. Animals from experimental group I received cephalexin in the single dose of 42 mg/24h, Animals from experimental group II received cephalexin in the dose of 42 mg/24h and 20% ethanol ad libitum. After 10 days animals were decapitated. Histological examinations (H+E staining and PAS reaction) were made on 7 micro thick paraffin slices. It was stated that ethanol causes hyperemia of the renal parenchyma and cephalexin stimulates diuresis. However, concomitant administration of ethanol and cephalexin causes functional changes (inhibition of diuresis) and degenerative changes in capillary loops of some renal corpuscles apart from hyperemia.
Department and Institute of Histology and Embryology with the Laboratory for Experimental Cytology, Medical University of Lublin, Lublin, Poland.
Mirosław
M
Lańcut
Alicja
A
Zarebska
Joanna
J
Sekita-Krzak
Krystyna
K
Czerny
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D002506:Cephalexin / Q000633:toxicity*; D004231:Diuresis / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; D000431:Ethanol; D002506:Cephalexin