Hitting the target with bifunctional phage.
Peptide libraries are rich sources of cell-targeting peptides. In this issue of Chemistry & Biology, Pasqualini and coworkers have developed a chimeric cell-targeting phage system that can easily be modified to delivery of a variety of reagents without need for chemical conjugation.
Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Kathlynn C
KC
Brown
D000818:Animals; D001435:Bacteriophages / Q000235:genetics*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008024:Ligands; D019151:Peptide Library; D015202:Protein Engineering; D011993:Recombinant Fusion Proteins / Q000235:genetics* / Q000378:metabolism*
D008024:Ligands; D019151:Peptide Library; D011993:Recombinant Fusion Proteins