Diagnostic correlation of CT-MRI and histopathology in 10 dogs with brain neoplasms.
Ten dogs with primary (n = 8) and metastatic (n = 2) brain tumours were studied in an attempt to evaluate the diagnostic sensitivity of computed tomography (CT) or magnetic resonance imaging (MRI). Of the clinical signs noticed, seizures (seven of 10), behavioural abnormalities and cognition dysfunction (seven of 10), compulsive walking and circling (six of 10), sensorimotor (five of 10) and neuro-opthalmological (two of 10) dysfunction were the most common. In all 10 animals that finally died of the disease or were killed, the histopathological diagnosis that followed necropsy was taken as a golden standard in the CT or MRI prediction of the histological type of brain neoplasms. In every instance, tumour detection, morphology and histological differentiation were possible with the aid of either CT (seven of 10) or MRI (three of 10) imaging especially after contrast enhancement. Only one CT-evaluated dog, diagnosed as meningioma, was found to be astrocytoma on histopathology. Interestingly, a rare case of cerebellar medulloblastoma was correctly identified in MRI scans.
Laboratory of Clinical Diagnosis and Clinical Pathology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Stavrou Voutyra 11, 546 27 Thessaloniki, Greece. poliz@vet.auth.gr
Z S
ZS
Polizopoulou
A F
AF
Koutinas
V D
VD
Souftas
E
E
Kaldrymidou
G
G
Kazakos
G
G
Papadopoulos
D000818:Animals; D001254:Astrocytoma / Q000150:complications / Q000175:diagnosis / Q000662:veterinary; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D004285:Dogs; D005260:Female; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008579:Meningioma / Q000150:complications / Q000175:diagnosis / Q000662:veterinary; D009362:Neoplasm Metastasis; D011237:Predictive Value of Tests; D012640:Seizures / Q000209:etiology / Q000662:veterinary; D014057:Tomography, X-Ray Computed / Q000662:veterinary*