Pyridylthiocarbazide complexes of rhenium with potential radiopharmaceutical applications.
Attachment of a thioamide tethering group provides a modification of the well-known pyridylhydrazine based route to radiolabelling of biomolecules (the HYNIC system) and gives a proligand which gives stable, well-defined chelated derivatives with both Re(v) oxo and Re(III) diazenide cores. Both display previously unknown bonding modes for the pyridylthiocarbazide ligands.
Clarke
Carole
C
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.
Cowley
Andrew R
AR
Dilworth
Jonathan R
JR
Donnelly
Paul S
PS
D018360:Crystallography, X-Ray; D006834:Hydrazines / Q000737:chemistry*; D007202:Indicators and Reagents; D007553:Isotope Labeling; D008958:Models, Molecular; D011868:Radioisotopes; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*
D006834:Hydrazines; D007202:Indicators and Reagents; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium