Pharmacokinetic study on lovastatin sustained-release tablet and sustained-release capsule in Beagal dogs.
This study pharmacokinetically examined the lovastatin sustained-release tablet and sustained-release capsule in Beagle dogs. An reversed-phase HPLC method was established for the determination of lovastatin in Beagle dog plasma. Pharmacokinetic findings were compared among three preparation(lovastatin sustained-release tablet, Tp; sustained-release capsule, TJ and conventional capsule). Our results showed that the pharmacokinetic parameters in 6 dogs after single-dose oral administration of three perparations were calculated. Tmax, Cmax and MRT revealed significant difference (P<0.05). Relative bioavailability was 111.5 +/- 16.9% (Tp) and 110.4% +/- 9.6% (Tj). The pharmacokinetic parameters in the 6 dogs after multiple-dose oral administration of three perparations, Tmax, Cmax MRT and DF had significant difference (P < 0.05); Cav, Cmin and AUC0-24 h displayed no significant difference (P>0.05). It is concluded that the lovastatin sustained-release tablet and sustained-release capsule are able to maintain a sustained-release for 24 h.
Department of Pharmacology, Tongji Medical College, of Huazhong University of Science and Technology, Wuhan 430030, China.
Lin
L
Fu
Zongshun
Z
Dai
Shuxian
S
Hou
Yuansheng
Y
Wan
D000818:Animals; D000924:Anticholesteremic Agents / Q000493:pharmacokinetics*; D002214:Capsules; D003692:Delayed-Action Preparations; D004285:Dogs; D005260:Female; D008148:Lovastatin / Q000493:pharmacokinetics*; D008297:Male; D013607:Tablets
D000924:Anticholesteremic Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D013607:Tablets; D008148:Lovastatin