USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome.
The upstream stimulatory factor (USF) proteins are ubiquitously expressed and, as such, represent unusual candidates for involvement in disorders of carbohydrate and lipid metabolism. Nonetheless, a recent study has reported an association between specific alleles of USF1 and familial combined hyperlipidaemia, a common disorder that substantially increases the risk of premature atherosclerotic cardiovascular disease. USF1 might, therefore, also contribute to the metabolic syndrome. The use of chromatin immunoprecipitation methodologies combined with promoter microarray assays will help to define the transcriptional networks that underlie whole-body glucose and lipid homeostasis.
MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. carol.shoulders@csc.mrc.ac.uk
Carol C
CC
Shoulders
Rossi P
RP
Naoumova
D004268:DNA-Binding Proteins / Q000502:physiology*; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000209:etiology* / Q000378:metabolism; D016350:Leucine Zippers; D050356:Lipid Metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology* / Q000378:metabolism; D010375:Pedigree; D014157:Transcription Factors / Q000502:physiology*; D051720:Upstream Stimulatory Factors
D004268:DNA-Binding Proteins; D014157:Transcription Factors; C497181:USF1 protein, human; D051720:Upstream Stimulatory Factors