Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc.
Phosphoramidite ligands, based on ortho-substituted biphenols and a chiral amine, induce high enantioselectivities (ee's up to 99%) in the copper-catalyzed conjugate addition of dialkylzinc reagents to a variety of Michael acceptors. Particularly, the best reported ee's were obtained for acyclic nitroolefins.
Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, Genève 4, Switzerland CH-1211. alexandre.alexakis@chiorg.unige.ch
Alexandre
A
Alexakis
Damien
D
Polet
Stéphane
S
Rosset
Sébastien
S
March