Current issues in the utility of 19F nuclear magnetic resonance methodologies for the assessment of tumour hypoxia.
It is now well established that uncontrolled proliferation of tumour cells together with the chaotic and poorly regulated blood supply of solid tumours result in tissue hypoxia, and that hypoxic regions of tumours are resistant to radiotherapy and chemotherapy. The development and application of non-invasive methods to rapidly determine the degree and extent of tumour hypoxia in an individual tumour would clearly enhance cancer treatment strategies. This review describes the current status of two (19)F nuclear magnetic resonance (NMR) methodologies that have been exploited to investigate tumour hypoxia, namely: (i) (19)F NMR oximetry following administration of perfluorocarbons, from which tumour p(O)(2) measurements can be made; and (ii) (19)F NMR measurements of the tumour retention of fluorinated 2-nitroimidazoles.
Robinson
Simon P
SP
Department of Basic Medical Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. s.robinson@sghms.ac.uk
Griffiths
John R
JR
D005461:Fluorine / Q000737:chemistry*; D005466:Fluorocarbons; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000175:diagnosis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009369:Neoplasms / Q000150:complications*; D009593:Nitroimidazoles / Q000737:chemistry; D010092:Oximetry
D005466:Fluorocarbons; D009593:Nitroimidazoles; D005461:Fluorine