Effects of surface processing of lactose carrier particles on dry powder inhalation properties of salbutamol sulfate.
The effects of the surface processing of lactose carrier particles on the dry powder inhalation properties of salbutamol sulfate were investigated. Lactose carrier particles were processed using a high-speed elliptical-rotor-type powder mixer (Theta-Composer). In the present study, drug/carrier powder mixtures were prepared, consisting of micronized salbutamol sulfate and coarse lactose carriers with various particle surface conditions prepared by surface processing. These powder mixtures were aerosolized by a Jethaler, and the in vitro inhalation properties of salbutamol sulfate were evaluated with a twin impinger. Compared with those of the powder mixed with unprocessed lactose carriers, the in vitro inhalation properties of the powder mixture prepared using the surface processed lactose carriers were significantly different, showing that the in vitro inhalation properties of salbutamol sulfate were improved. The in vitro inhalation properties increased with the rotor rotation rate. Using this surface processing system would thus be valuable for increasing the inhalation properties of dry powder inhalation with lactose carrier particles.
Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan. iida@ccmfs.meijo-u.ac.jp
Kotaro
K
Iida
Yukari
Y
Inagaki
Hiroaki
H
Todo
Hirokazu
H
Okamoto
Kazumi
K
Danjo
Hans
H
Luenberger
D000280:Administration, Inhalation; D000420:Albuterol / Q000008:administration & dosage / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D007785:Lactose / Q000008:administration & dosage / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature; D014961:X-Ray Diffraction
D001993:Bronchodilator Agents; D004337:Drug Carriers; D011208:Powders; D007785:Lactose; D000420:Albuterol