Spectral karyotyping indicates complex rearrangements in lung adenocarcinoma of nonsmokers.
Adenocarcinoma (AdC) of the lung represents a common histologic subtype of non-small cell lung cancer. While there is a rising incidence of AdC in nonsmoking women, information on the cytogenetic changes involved has been minimal to date. In the present study, spectral karyotyping analysis uncovered the genome-wide chromosomal aberrations in two AdC tumors derived from women who were lifelong nonsmokers. Simple and complex structural rearrangements were indicated. A ploidy status of hypertetraploidy was suggested in both cases, with recurring derivative translocations involving chromosome arms 3q, 8q, 12q, 15q, 22q, and Xq.
Department of Clinical Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., SAR Hong Kong, China.
Shirley Ming-Hui
SM
Sy
Boli
B
Fan
Tak-Wai
TW
Lee
Tony S-K
TS
Mok
Elizabeth
E
Pang
Anthony
A
Yim
Nathalie
N
Wong
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D000782:Aneuploidy; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D032681:Spectral Karyotyping; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured / Q000648:ultrastructure