Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.
Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines. Chemical transformations performed on these compounds have yielded derivatives more potent and more selective that the parent compound. Most of the compounds maintained their cytotoxicity at the microM level. Distribution, biosynthesis, production, biotechnology, applications and synthesis have also been reviewed.
Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain. mliza@usal.es
M
M
Gordaliza
P A
PA
García
J M Miguel
JM
del Corral
M A
MA
Castro
M A
MA
Gómez-Zurita
D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology*; D005047:Etoposide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000145:classification; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology; D010947:Plants, Toxic / Q000737:chemistry*; D011034:Podophyllotoxin / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology*; D013713:Teniposide / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D003603:Cytotoxins; D017705:Lignans; D009943:Organophosphorus Compounds; C061400:etoposide phosphate; D005047:Etoposide; D013713:Teniposide; D011034:Podophyllotoxin