[Pulmonary thromboendarterectomy].
Chronic thromboembolic pulmonary hypertension with concomitant right heart failure may develop as a sequela of acute pulmonary embolism with organization instead of thrombolysis of intravascular clots. Medical therapy aims at prevention of recurrent embolism by anticoagulation and vascular remodelling using vasodilator therapy. Lung transplantation or combined heart-lung transplantation is associated with unsatisfactory long-term results and comorbidity and therefore remains justified only in selected patients. Pulmonary thromboendarterectomy allows specific treatment of intravascular obstruction. This closed endarterectomy of the pulmonary arteries requires deep hypothermic circulatory arrest and can be performed with a perioperative mortality of less than 10%. The procedure significantly decreases pulmonary vascular resistance and often normalizes pulmonary hemodynamics and gas exchange. Postoperatively the patients' clinical condition improves and the majority have normal exercise capacity and activity.
Abteilung für Thorax- und Herz-/Gefässchirurgie, Chirurgische Universitätsklinik, Homburg/Saar. henning.lausberg@uniklinik-saarland.de
H F
HF
Lausberg
D
D
Tscholl
H-J
HJ
Schäfers
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000601:surgery*; D004691:Endarterectomy; D006333:Heart Failure / Q000150:complications; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D011182:Postoperative Care; D011651:Pulmonary Artery / Q000601:surgery*