Parkinson's disease-like presentation of multiple system atrophy with poor response to STN stimulation: a clinicopathological case report.
We report on a clinicopathological case of multiple system atrophy with good response to levodopa and subsequent development of motor complications. Because the subject complied with all the inclusion criteria (Core Assessment Program for Surgical Interventional Therapies in Parkinson's Disease), bilateral subthalamic nucleus deep brain stimulation electrodes were implanted.
Service of Neurology, Hospital of Cruces, Neurosciences Department, University of the Basque Country, Spain.
Elena
E
Lezcano
Juan C
JC
Gómez-Esteban
Juan J
JJ
Zarranz
Rafael
R
Alcaraz
Begoña
B
Atarés
Gaizka
G
Bilbao
Jesús
J
Garibi
Imanol
I
Lambarri
D000978:Antiparkinson Agents / Q000627:therapeutic use; D001549:Benzamides / Q000493:pharmacokinetics; D018492:Dopamine Antagonists / Q000493:pharmacokinetics; D004599:Electric Stimulation Therapy; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications* / Q000000981:diagnostic imaging; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D011759:Pyrrolidines / Q000493:pharmacokinetics; D012189:Retrospective Studies; D013194:Staining and Labeling; D020531:Subthalamic Nucleus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D051843:Synucleins; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D000978:Antiparkinson Agents; D001549:Benzamides; D018492:Dopamine Antagonists; D009419:Nerve Tissue Proteins; D011759:Pyrrolidines; D051843:Synucleins; D007980:Levodopa; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide