[A randomized study of efficacy of regimes of large-fraction irradiation for metastatic lesions to the skeleton. (I) Single factor analysis].
A randomized study included 167 patients with metastases to the bone (breast cancer--73%). 117 patients received distance radiotherapy on an area-by-area basis: 2 areas--30, and 3 or more areas--20. Radiotherapy was not used until chemo-hormonal proved useless. The following four regimes were used (1) 4 fractions of 6.5 Gy each (overall dosage--26 Gy) (2 fractions per week); (2) 5 fractions of 6.5 Gy each (overall dosage--32.5 Gy) (2 fractions per week); (3) 4 daily fractions of 6.5 Gy each (overall dosage--26 Gy), and (4) 23 fractions (overall dosage--46 Gy) (5 weekly fractions). Overall efficacy was 96.7% (complete response--66.7%; pain syndrome in the exposed area--4.2%). No differences between large-fraction irradiation regimes were reported. Late-onset radiation-induced lesions (soft-tissue fibrosis stage II-III) were significantly more frequent after standard low-dosage fractionated irradiation (28.6+/-17.0%).
Khelevskiĭ
E V
EV
Panyshin
G A
GA
D001859:Bone Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011829:Radiation Dosage