Water exercise prevents femur density loss associated with ovariectomy in the retired breeder rat.
The effect of non-weight-bearing exercise on skeletal bone remains controversial. The objective of this pilot study was to examine the effects of water exercise training on femur density and serum alkaline phosphatase activity in ovariectomized and sham-operated (ovaries left intact) retired breeder rats. Exercised animals swam at progressively increasing duration from 5 minutes to 75 min.d(-1), 5 d.wk(-1), for a 6-week conditioning period. Exercised rats had greater (p < 0.02) soleus muscle citrate synthase activity than sedentary rats, confirming an aerobic training effect. Femur density (g.cm(-3)) was greater (p < 0.0007) for exercised rats than sedentary rats but lower (p < 0.01) for ovariectomized rats compared to sham rats. Serum alkaline phosphatase activity tended (p < 0.06) to be greater for exercised rats compared to sedentary rats. These results indicate that dynamic water-flotation exercise prevents the femur bone loss associated with ovariectomy in rats. We conclude that this form of exercise could be beneficial in maintaining bone density in hormone-deficient postmenopausal women, especially the elderly who may not be able to perform weight-bearing activities.
Melton
Sheri A
SA
Department of Kinesiology, School of Health Sciences, West Chester University, Pennsylvania 19383, USA. smelton@wcupa.edu
Hegsted
Maren
M
Keenan
Michael J
MJ
Morris
G Stephen
GS
O'Neil
Carol E
CE
Zablah-Pimentel
Erika M
EM
D000818:Animals; D015519:Bone Density; D002950:Citrate (si)-Synthase / Q000378:metabolism; D004195:Disease Models, Animal; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005269:Femur / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000201:enzymology; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D010052:Ovariectomy / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013550:Swimming
D002950:Citrate (si)-Synthase