Hepatoprotective activity of Haridradi ghrita on carbon tetrachloride-induced liver damage in rats.
Haridradi ghrita, a ghee based polyherbal formulation, (50, 100, 200 and 300 mg/kg) significantly lowered marker enzymes (SGPT, SGOT, ALP) and bilirubin in serum and liver peroxide, superoxide dismutase and catalase in liver homogenate following CCl4 (0.7 ml/kg, ip) toxicity. The protective effect was further supported by reversal of CCl4 induced histological changes. The results demonstrate significant hepatoprotective action of H. ghrita in CCl4 damaged rats.
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur 440 010, India.
P M
PM
Satturwar
S V
SV
Fulzele
S B
SB
Joshi
A K
AK
Dorle
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004041:Dietary Fats / Q000032:analysis*; D015227:Lipid Peroxidation; D008099:Liver / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D004041:Dietary Fats; D002251:Carbon Tetrachloride