Use of antibacterial agents in renal failure.
This article provides background information on the pharmacokinetics of antibacterial agents in patients with normal and impaired renal function. Tables are provided to allow quick determination of appropriate dosages for varying degrees of renal failure. The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.
Department of Medicine, Drexel University College of Medicine, 2900 W. Queen Lane, Philadelphia, PA 19129, USA. santorow@mlhs.org
Lawrence L
LL
Livornese
Dorothy
D
Slavin
Brett
B
Gilbert
Paul
P
Robbins
Jerome
J
Santoro
D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D003956:Dialysis; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D051437:Renal Insufficiency / Q000150:complications / Q000503:physiopathology*
D000900:Anti-Bacterial Agents