The significance of placenta growth factor in angiogenesis and clinical outcome of human gastric cancer.
Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of proangiogenic factors and its overexpression has been linked to pathological angiogenesis. We studied the relationship between the expression of PlGF and VEGF in human gastric cancer tissues and microvessel density (MVD), as well as clinical outcome in 79 patients with gastric cancer by using an enzyme immunoassay for PlGF and VEGF expression levels in gastric cancers and surrounding non-cancerous mucosa. PlGF protein levels were significantly higher in tumor than in the corresponding non-tumorous mucosa (median value 48.5 vs 9.8 pg/mg, P < 0.001). In contrast, VEGF protein levels were not (66.7 vs 80.7 pg/mg, P = 0.522). VEGF expression level was not significantly correlated with MVD, patient survival, and clinicopathological factors except Lauren classification in this study. PlGF may be an important angiogenic factor in human gastric cancer, and PlGF expression level was significantly correlated with serosal invasion, positive lymph node metastases, tumor stages, and patient survival.
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Chiung-Nien
CN
Chen
Fon-Jou
FJ
Hsieh
Yunn-Ming
YM
Cheng
Wen-Fan
WF
Cheng
Yi-Ning
YN
Su
King-Jen
KJ
Chang
Po-Huang
PH
Lee
D014408:Biomarkers, Tumor / Q000032:analysis*; D005753:Gastric Mucosa; D006133:Growth Substances; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D009389:Neovascularization, Pathologic; D010920:Placenta; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000032:analysis / Q000096:biosynthesis*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology*; D016019:Survival Analysis; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D006133:Growth Substances; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor