[Single-lung transplantation and contralateral lung volume reduction for emphysema].
OBJECTIVE
To report the operation technique, patient selection and curative effect of single-lung transplantation with contralateral lung volume reduction for a patient with end-stage emphysema.


METHODS
A 47-year-old male patient who was dependent on mechanical ventilation because of end-stage emphysema received left-lung transplantation on 20 June, 2003. The surgical technique used was similar to that mentioned in the literature. The donor lung was perfused by low-potassium dextran solutions (LPD) with a cold ischemic time of 390 minutes. The patient received contralateral lung volume reduction because of subacute native lung hyperinflation on the 7th day after operation. He was received tracheostomy on 15th day after operation and was weaned from ventilator on the 26th day post-operation. Immunosuppression included cyclosporine, mycophenolate mofetil and corticosteroid. The acute rejection occurred on the 9th and 15th days after operation and was cured successfully.


RESULTS
The lung function was improved significantly and the patient was discharged from hospital 71 days after operation.


CONCLUSIONS
Single-lung transplantation combined with contralateral lung volume reduction for end-stage emphysema is an effective measure for subacute native lung hyperinflation. Further follow-up is required to assess the long term results of this procedure.
Department of Thoracic Surgery, Fifth People's Hospital of Wuxi, Affiliated Hospital of Jiangnan University, Wuxi 214073, China.
Jing-yu
JY
Chen
Ming-feng
MF
Zheng
Yi-jun
YJ
He
Da-wei
DW
Zhu
Qian-kun
QK
Zhu
Ruo
R
Chen
Zheng-xing
ZX
Su
Shu-gao
SG
Ye
Feng
F
Liu
D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000601:surgery; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging / Q000601:surgery*; D014019:Tissue Donors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome