Desymmetrizing hydroformylation with the aid of a planar chiral catalyst-directing group.
Desymmetrizing hydroformylation of bisalkenyl- and bisallylcarbinols could be achieved employing a chiral substrate-bound catalyst-directing group (o-DPPF) with excellent levels of diastereotopic alkene face and diastereotopic alkene group discrimination to give bifunctionalized chiral aldehydes in enantiomerically pure form.
Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Germany. bernhard.breit@organik.chemie.uni-freiburg.de
Bernhard
B
Breit
Daniel
D
Breuninger