Efficacy and side effect profile of varying doses of intrathecal fentanyl added to bupivacaine for labor analgesia.
The purpose of this randomized, double blinded and controlled study was to determine the optimal dose of intrathecal fentanyl when combined with bupivacaine 2.5 mg for initiation of labor analgesia. Parous parturients with cervical dilation between 3 and 5 cm were randomized to receive intrathecal fentanyl 0 (control), 5, 10, 15, 20 or 25 micrograms, combined with bupivacaine 2.5 mg, followed by a lidocaine/epinephrine epidural test dose. Visual analog pain scores (VAPS) and the presence of side effects were determined every 15 min until the parturient requested additional analgesia. Fetal heart rate (FHR) tracings were compared between groups. All parturients who received fentanyl >/= 15 micrograms had VAPS < 20 mm and duration of analgesia > 15 min, but this was not true for all parturients with fentanyl doses < 15 micrograms. Duration of analgesia was shorter for fentanyl groups 0, 5 and 10 micrograms, compared to groups 15, 20 and 25 micrograms, but there was no difference between the 15, 20 and 25 micrograms groups. There was no difference in the incidence of nausea and vomiting, or in FHR tracing changes. The incidence of pruritus was greater in all fentanyl groups compared to control. These data suggest that, when combined with intrathecal bupivacaine 2.5 mg, fentanyl 15 micrograms provides satisfactory analgesia to all parturients. Higher fentanyl doses produced no additional benefit in duration or quality of analgesia.
Department of Anesthesiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. c-wong2@northwestern.edu
C A
CA
Wong
B M
BM
Scavone
J P
JP
Slavenas
M I
MI
Vidovich
A M
AM
Peaceman
J N
JN
Ganchiff
T
T
Strauss-Hoder
R J
RJ
McCarthy
D000328:Adult; D016362:Analgesia, Obstetrical; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D000779:Anesthetics, Local; D002045:Bupivacaine; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007278:Injections, Spinal; D010121:Oxytocin / Q000627:therapeutic use; D010147:Pain Measurement; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology; D011247:Pregnancy; D011537:Pruritus / Q000453:epidemiology
D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D010121:Oxytocin; D005283:Fentanyl; D002045:Bupivacaine