Effect of the estrous cycle on water maze acquisition depends on the temperature of the water.
The literature on the effects of ovarian hormones on rodent learning and memory is mixed. In this study, the authors examined the role of task stressfulness. Female hooded rats were tested during proestrus or estrus on the hidden-platform water maze in warm (33 degrees C) or cold (19 degrees C) water. There were no effects of cycle or temperature, but estrous phase interacted with temperature such that proestrous rats performed better overall under the warm condition and estrous rats performed better under the cold condition. Plasma corticosterone, measured after 4 trials, varied significantly with estrous phase. Water temperature, perhaps through stress, influences the effect of estrous phase on water maze performance.
Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA.
Marisa J
MJ
Rubinow
Linda M
LM
Arseneau
J Lee
JL
Beverly
Janice M
JM
Juraska
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D001831:Body Temperature / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D030762:Estrous Cycle / Q000502:physiology*; D005260:Female; D018782:Maze Learning / Q000502:physiology*; D011863:Radioimmunoassay; D051381:Rats; D020318:Rats, Long-Evans; D013696:Temperature; D014867:Water
D014867:Water; D003345:Corticosterone