Probucol, a hypocholesterolemic agent, prevents the development of uterine adenomyosis induced by pituitary grafting in mice.
This in vivo experimental study was designed to investigate the effects of probucol, a hypocholesterolemic agent, on uterine adenomyosis which is frequently induced by pituitary grafting in mice. SHN mice, which are known to develop uterine adenomyosis spontaneously, and much sooner after pituitary grafting, were used and histopathological study on the uteri in pituitary gland-implanted mice with or without probucol treatment was performed. Four out of 10 pituitary gland-implanted mice developed uterine adenomyosis with dilated blood vessels, but none of the probucol-treated mice. There were no differences between pituitary-grafted mice with or without probucol treatment in body weight and wet weights of uterus, ovaries, kidney and liver except spleen. Probucol markedly reduced the serum levels of total cholesterol, free cholesterol, free fatty acids, phospholipids and triglycerides and, thus, this agent inhibited the incidence of uterine adenomyosis induced by pituitary grafting in mice.
Department of Obstetrics and Gynecology, The First School of Clinical Medicine, Beijing University, China.
Ying-Fang
YF
Zhou
Takao
T
Mori
Hiroshi
H
Nagasawa
Tohru
T
Nakayama
Toshiro
T
Kubota
Shinobu
S
Sakamoto
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004715:Endometriosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D007150:Immunohistochemistry; D008055:Lipids / Q000097:blood; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000637:transplantation*; D011341:Probucol / Q000494:pharmacology*; D014591:Uterine Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
D000924:Anticholesteremic Agents; D008055:Lipids; D014841:von Willebrand Factor; D011341:Probucol