EMSY links breast cancer gene 2 to the 'Royal Family'.
Although the role of the breast cancer gene 2 (BRCA2) tumor suppressor gene is well established in inherited breast and ovarian carcinomas, its involvement in sporadic disease is still uncertain. The recent identification of a novel BRCA2 binding protein, EMSY, as a putative oncogene implicates the BRCA2 pathway in sporadic tumors. Furthermore, EMSY's binding to members of the 'Royal Family' of chromatin remodeling proteins may lead to a better understanding of the physiological function of BRCA2 and its role in chromatin remodeling.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Jun
J
Yao
Kornelia
K
Polyak
D001943:Breast Neoplasms / Q000235:genetics*; D024522:Genes, BRCA2; D006801:Humans; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins / Q000235:genetics*
C480344:EMSY protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins