MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels.
MCP-1 levels are increased in CSF of patients with Alzheimer's disease (AD) compared with controls, suggesting a role in the development of dementia. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. The distribution of the A-2518G SNP was determined in 269 AD patients and in 203 healthy age matched controls, showing no differences between the two groups. On the contrary, a significant increase of MCP-1 serum levels in AD patients carrying at least one G mutated allele was observed. Moreover, the highest peaks of MCP-1 serum levels were present in patients carrying two G alleles. Stratifying by ApoE genotype, gender or age at onset, no differences in both allele frequency and MCP-1 serum concentration were observed. The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD.
Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.
Chiara
C
Fenoglio
Daniela
D
Galimberti
Carlo
C
Lovati
Ilaria
I
Guidi
Alberto
A
Gatti
Sergio
S
Fogliarino
Marco
M
Tiriticco
Claudio
C
Mariani
Gianluigi
G
Forloni
Carla
C
Pettenati
Pierluigi
P
Baron
Giancarlo
G
Conti
Nereo
N
Bresolin
Elio
E
Scarpini
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics* / Q000276:immunology; D018932:Chemokine CCL2 / Q000097:blood / Q000235:genetics*; D018925:Chemokines / Q000276:immunology; D002634:Chemotaxis, Leukocyte / Q000235:genetics* / Q000276:immunology; D004252:DNA Mutational Analysis; D004660:Encephalitis / Q000097:blood / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D015854:Up-Regulation / Q000235:genetics / Q000276:immunology
D018932:Chemokine CCL2; D018925:Chemokines