Fomepizole alone for severe infant ethylene glycol poisoning.
OBJECTIVE
To report a case of a massive ingestion of ethylene glycol in an infant successfully treated by fomepizole without hemodialysis.


METHODS
Descriptive case report.


METHODS
Pediatric intensive care unit.


METHODS
A 5-mo-old boy who ingested 200 mL of an antifreeze solution.


METHODS
Antidotal therapy with a total of seven doses of fomepizole administered intravenously with an interval of 12 hrs (15 mg/kg as loading dose, then 10 mg/kg). Hemodialysis was not performed.


RESULTS
Iterative determination of ethylene glycol concentration was obtained in blood and urine. Kinetics were calculated for ethylene glycol and fomepizole elimination. The infant made a complete recovery with no change in renal function.


CONCLUSIONS
Although not yet approved for this indication in the child, fomepizole seemed safe and effective in a case of severe ethylene glycol poisoning, without the need for hemodialysis.
Pediatric Intensive Care Unit, St-Luc Hospital, Université catholique de Louvain, Brussels, Belgium.
Thierry
T
Detaille
Pierre
P
Wallemacq
Stephan
S
Clément de Cléty
Roger
R
Vanbinst
Guy
G
Dembour
Philippe
P
Hantson
D000061:Accidents, Home; D000931:Antidotes / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004638:Emergency Treatment; D019855:Ethylene Glycol / Q000506:poisoning*; D005500:Follow-Up Studies; D000077604:Fomepizole; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008297:Male; D011041:Poisoning / Q000188:drug therapy* / Q000209:etiology; D011720:Pyrazoles / Q000008:administration & dosage*; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000931:Antidotes; D011720:Pyrazoles; D000077604:Fomepizole; D019855:Ethylene Glycol