Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival.
Oral Squamous Cell Carcinoma (OSCC) is a common malignancy. Treatment failure is mainly due to loco-regional disease recurrence. KAI1 is a newly discovered metastasis suppressor gene. Fifty-seven patients with primary OSCC underwent surgery alone or surgery and adjuvant radiotherapy. Immunohistochemical evaluation of KAI1/CD82 and p53 proteins was carried out on specimen obtained at surgery. Within neoplastic fields, KAI1/CD82 expression was downregulated and negative in 42/57 (73.7%) cases. p53 expression was positive in 26/57 (45.6%) cases. No correlation was noted between KAI1/CD82 and p53 expression or clinicopathological parameters. Univariate and multivariate Cox proportional hazard models showed a correlation between KAI1/CD82 expression with disease free survival (P = 0.01, P = 0.009) and overall survival (P = 0.04, P = 0.053) respectively.
Department of Otolaryngology Surgery, Prince of Wales Hospital, UNSW, Randwick 2031, Sydney NSW, Australia. rostam74@yahoo.com.au
Ross D
RD
Farhadieh
Robert
R
Smee
Kim
K
Ow
Jia Lin
JL
Yang
Pamela J
PJ
Russell
Roger
R
Crouch
Paul
P
Jackson
Ian V
IV
Jacobson
D000368:Aged; D015703:Antigens, CD; D000954:Antigens, Surface; D002277:Carcinoma / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D015331:Cohort Studies; D018572:Disease-Free Survival; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051861:Kangai-1 Protein; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D011518:Proto-Oncogene Proteins; D018714:Radiotherapy, Adjuvant
D015703:Antigens, CD; D000954:Antigens, Surface; C497688:CD82 protein, human; D051861:Kangai-1 Protein; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins