[Influence of seven absorption enhancers on nasal mucosa--assessment of toxicity].
OBJECTIVE
To study the influence of seven different absorption enhancers on nasal mucosa.


METHODS
By testing last time of ciliary movement, velocity of ciliary movement, ciliary structural and specific cellular changes of nasal mucosa  the influence of seven different absorption enhancers on nasal mucosa.


RESULTS
The effect on lasting time of ciliary movement was 1%SDS>1%SDC>1%Brij35>5%Tween80>0.1%EDTA>5%HP-beta-CD>1%lecithin the effect on velocity of ciliary movement 1%Brij35>1%SDC>1%SDS>0.1%EDTA>1%lecithin>5%Tween80>5%HP-beta-CD,and the effect on ciliary structural and specific cellular changes of nasal mucosa 1%SDS approximately 1%SDC approximately 1%Brij35>5%Tween80>0.1%EDTA approximately 5% HP-beta-CD approximately 1%lecithin.


CONCLUSIONS
The three methods have good correlation.
Department of Pharmaceutics, Peking University School of Pharmacy, Beijing 100083, China.
Ying
Y
Zhao
Da-wei
DW
Zhang
Ai-ping
AP
Zheng
Shao-yun
SY
Yu
Feng-lan
FL
Wu
D000042:Absorption / Q000187:drug effects; D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage* / Q000633:toxicity; D000281:Administration, Intranasal; D000818:Animals; D002023:Bufo bufo; D002923:Cilia / Q000187:drug effects* / Q000502:physiology; D003505:Cyclodextrins / Q000008:administration & dosage / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D054709:Lecithins / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D010455:Peptides / Q000008:administration & dosage / Q000633:toxicity; D011136:Polysorbates / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000633:toxicity
D000277:Adjuvants, Pharmaceutic; D003505:Cyclodextrins; D054709:Lecithins; D010455:Peptides; D011136:Polysorbates; D012967:Sodium Dodecyl Sulfate