Mild and effective N-phthaloylation of amino acids.
In the present work various free amino acids, including tryptophan and tyrosine, were effectively N-phthaloylated under reduced pressure and at lower temperature. Moreover, under these conditions, the presence of phthalic acid in phthalic anhydride did not hinder the N-phthaloylation of amino acids. This simple process is economic, environmentally friendly, and suitable for large-scale production.
Zeng
Q
Q
Institute of Pharmacy, Chengdu Di'ao Pharmaceutical Group, Chengdu, China. qinglezeng@yahoo.com
Liu
Z
Z
Li
B
B
Wang
F
F
D000596:Amino Acids / Q000737:chemistry*; D002621:Chemistry / Q000379:methods*; D008956:Models, Chemical; D010766:Phosphorylation; D010796:Phthalic Anhydrides / Q000737:chemistry / Q000494:pharmacology*; D013696:Temperature; D013997:Time Factors
D000596:Amino Acids; D010796:Phthalic Anhydrides; C043103:phthalic anhydride