Brain activation patterns during a verbal fluency test-a functional MRI study in healthy volunteers and patients with schizophrenia.
FMRI was used to study cortical activation patterns in nine healthy male subjects and nine high-functioning male schizophrenia patients during a letter verbal fluency task. Both groups showed similar patterns of activation, however, in controls the activation was primarily in the left broca area, while for schizophrenia patients, it was more bilateral. These data indicate that high-functioning schizophrenia patients show a reduced language lateralization of the frontal cortex compared to healthy controls.
Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck, Austria. elisabeth.weiss@uibk.ac.at
Elisabeth M
EM
Weiss
Alex
A
Hofer
Stefan
S
Golaszewski
Christian
C
Siedentopf
Claudia
C
Brinkhoff
Christian
C
Kremser
Stefan
S
Felber
W Wolfgang
WW
Fleischhacker
D000328:Adult; D005625:Frontal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000378:metabolism* / Q000503:physiopathology*; D014705:Verbal Behavior; D014825:Vocabulary