Activated platelets in transient global amnesia and TIA.
To assess whether platelets are activated in transient global amnesia (TGA) and TIA, blood samples were analyzed by fluorescence-activated cytoscan using antibodies specific for platelet fibrinogen receptor (PAC1) and P-selectin (CD62P). Samples from TIA contained high levels of CD62P compared with age-matched control subjects, whereas those from TGA did not. The authors suggest that activated platelets are involved in brain ischemia, whereas ischemia appears not to be associated with most TGA.
Department of Neurology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259-1193, Japan. hhirabay@is.icc.u-tokai.ac.jp
Hisayuki
H
Hirabayashi
Mie
M
Shimizu
Saori
S
Kohara
Yukito
Y
Shinohara
D000368:Aged; D000647:Amnesia / Q000097:blood*; D001792:Blood Platelets / Q000737:chemistry; D002544:Cerebral Infarction / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D006973:Hypertension / Q000097:blood; D002546:Ischemic Attack, Transient / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000032:analysis; D015539:Platelet Activation; D039341:Receptors, Fibrinogen / Q000032:analysis; D012307:Risk Factors; D012907:Smoking / Q000097:blood
D019007:P-Selectin; D039341:Receptors, Fibrinogen