RNA transport (partly) revealed!
Specific mRNAs are transported to dendrites where their translation may modify synaptic plasticity. In this issue of Neuron, Kanai et al. use affinity chromatography and mass spectrometry to identify a large number of new factors that associate with kinesin, a molecular motor, and employ siRNA technology to demonstrate their importance for RNA transport in neurons.
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Joel D
JD
Richter
D000818:Animals; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D034443:RNA Transport / Q000502:physiology*
D016547:Kinesins