Dietary prevention of allergic diseases in infants and small children. Part III: Critical review of published peer-reviewed observational and interventional studies and final recommendations.
The role of primary prevention of allergic diseases has been a matter of debate for the last 40 years. In order to shed some light on this issue, a group of experts of the Section of Pediatrics EAACI reviewed critically the existing literature on the subject. An analysis of published peer-reviewed observational and interventional studies was performed following the statements of evidence as defined by WHO. The results of the analysis indicate that breastfeeding is highly recommended for all infants irrespective of atopic heredity. A dietary regimen is unequivocally effective in the prevention of allergic diseases in high-risk children. In these patients breastfeeding combined with avoidance of solid food and cow's milk for at least 4-6 months is the most effective preventive regimen. In the absence of breast milk, formulas with documented reduced allergenicity for at least 4-6 months should be used.
Department of Pediatrics, University of Padua, Padua, Italy. muraro@pediatria.unipd.it
Antonella
A
Muraro
Sten
S
Dreborg
Susanne
S
Halken
Arne
A
Høst
Bodo
B
Niggemann
Rob
R
Aalberse
Syed H
SH
Arshad
Andrea von
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Berg Av
Kai-Håkon
KH
Carlsen
Karel
K
Duschén
Philippe
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Eigenmann
David
D
Hill
Catherine
C
Jones
Michael
M
Mellon
Göran
G
Oldeus
Arnold
A
Oranje
Cristina
C
Pascual
Susan
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Prescott
Hugh
H
Sampson
Magnus
M
Svartengren
Yvan
Y
Vandenplas
Ulrich
U
Wahn
Jill A
JA
Warner
John O
JO
Warner
Magnus
M
Wickman
Robert S
RS
Zeiger
D001942:Breast Feeding; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004032:Diet; D006801:Humans; D006967:Hypersensitivity / Q000517:prevention & control*; D007223:Infant; D016269:Milk Hypersensitivity / Q000517:prevention & control