[Course and therapy of an invasive aspergilloma of the skull base in a non-immunocompromised patient].
Fulminant-invasive sinus aspergillosis affects immunocompromised patients and is usually lethal because of intracranial complications. Chronic-invasive and non-invasive types occur in non-immunocompromised patients. In these cases, intracranial extension is possible and life-threatening. The effective management of sinus aspergillosis requires early diagnosis by CT and histological classification, surgery, and if necessary, chemotherapy or steroids in case of allergy. Here we report a successfully treated case in a 29-year-old non-immunocompromised patient with chronic-invasive sinus aspergillosis. He presented a recurrent sphenoid sinus aspergillosis with destruction of the clivus and ophthalmoplegia. Diagnostic and therapeutic procedures are described.
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde des Universitätsklinikum Hamburg-Eppendorf. swenzel@uke.uni-hamburg.de
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S
Wenzel
C
C
Sagowski
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W
Kehrl
F U
FU
Metternich
D000284:Administration, Oral; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020953:Neuroaspergillosis / Q000175:diagnosis* / Q000601:surgery; D009886:Ophthalmoplegia / Q000175:diagnosis / Q000601:surgery; D019291:Skull Base / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D013101:Sphenoid Sinus / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D015524:Sphenoid Sinusitis / Q000175:diagnosis* / Q000601:surgery; D007507:Therapeutic Irrigation; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D000666:Amphotericin B