Citrinadin A, a novel pentacyclic alkaloid from marine-derived fungus Penicillium citrinum.
[structure: see text] A novel pentacyclic alkaloid, citrinadin A (1), was isolated from the cultured broth of the fungus Penicillium citrinum, which was separated from a marine red alga, and the structure was elucidated by spectroscopic data. The relative stereochemistry of the pentacyclic core was assigned on the basis of NOESY data and (1)H-(1)H coupling constants, and the presence of an N,N-dimethyl-L-valine residue in 1 was determined by chiral HPLC analysis of the hydrolysate.
Tsuda
Masashi
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Kasai
Yuu
Y
Komatsu
Kazusei
K
Sone
Teruo
T
Tanaka
Michiko
M
Mikami
Yuzuru
Y
Kobayashi
Jun'ichi
J
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D026121:Indole Alkaloids; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D011807:Quinolizines / Q000737:chemistry* / Q000302:isolation & purification*; D000461:Rhodophyta; D014633:Valine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification
D000470:Alkaloids; D026121:Indole Alkaloids; D011807:Quinolizines; C503673:citrinadin A; D014633:Valine