Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome.
Taub
Jeffrey W
JW
Mundschau
Gina
G
Ge
Yubin
Y
Poulik
Janet M
JM
Qureshi
Faisal
F
Jensen
Tanya
T
James
S Jill
SJ
Matherly
Larry H
LH
Wechsler
Joshua
J
Crispino
John D
JD
D004268:DNA-Binding Proteins / Q000235:genetics*; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics*; D050981:Erythroid-Specific DNA-Binding Factors; D050982:GATA1 Transcription Factor; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications* / Q000235:genetics*; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human; D014157:Transcription Factors