[The dynamics of antioxidant enzyme activity and contents of lipid peroxides in walls of animal blood vessels during hyperadrenalinemia].
The alterations in activity of some antioxidant enzymes and the content of intermediate and final lipids per oxidation (LPO) in walls of different blood vessels during hyperadrenalinaemia were studied. An inversely proportional dependency between the degree of antioxidant activity of tissues and the level of accumulation of LPO was discovered. The dependency of studied indices on the duration of action of pathogenic factor was determined. The discovered dynamics of LPO accumulation in tissues and compensatory activation of antioxidant enzymes indicates on the active energy-dependent adapting feature of the mentioned alterations; the efficiency of cell adaptation to hyperadrenalinaemia and its consequences is likely to depend on the initial level of energy metabolism in the tissue and on possibilities of its maximal increase. The similarity in alterations in LPO content and antioxidant activity in organs was discovered; this fact is possibly determined by stereotype in mechanisms of pathogenesis of hyperadrenaline violations in arteriosclerosis. The obtained results can be used for more profound understanding of interdependence between the antioxidant enzyme activity and lipid mechanisms of cell injury and their role in pathogenesis of arteriosclerosis.
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Naumko
D000818:Animals; D001161:Arteriosclerosis / Q000201:enzymology / Q000378:metabolism*; D001808:Blood Vessels / Q000201:enzymology / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D004734:Energy Metabolism; D004837:Epinephrine / Q000008:administration & dosage / Q000097:blood*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism
D008054:Lipid Peroxides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D004837:Epinephrine