Classical and "non-classical" cardiovascular risk factors in Tunisian patients with end stage renal disease: prevalence and association with cardiovascular events.
This study was aimed to determine the prevalence of several classical and non-classical cardiovascular risk factors, and to test their association with cardiovascular events in Tunisian patients with end-stage renal disease. A total of 35 chronic renal failure, 50 hemodialysed and 30 renal transplant recipient patients and 31 healthy subjects were included. Hypertension, elevated plasma concentrations of total homocysteine, fibrinogen, C-reactive protein, and lipoprotein(a) were highly prevalent in patients, whereas, smoking, hypertriglyceridemia, hypercholesterolemia, hypoHDLemia, and hypoalbuminemia were less common. In univariate analysis, cardiovascular events were associated with age, hypertension, and the top quartile of the total homocysteine and C-reactive protein values. When controlling for several potential confounding factors, cardiovascular events remained associated with age, hypertension (OR, 7.07; 95% CI, 1.76-28.34; P=0.01), and the top quartile of total homocysteine (OR, 10.41; 95% CI, 2.61-41.55; P=0.001) and C-reactive protein (OR, 3.99; 95% CI, 1.06-14.99; P=0.04).
Fellah
Hayet
H
LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta Hospital, Tunis, Tunisia.
Feki
Moncef
M
Feki
Habib
H
Souissi
Malek
M
Kaabachi
Neziha
N
Ben Abdallah
Taieb
T
Massy
Ziad A
ZA
Ben Maiz
Hedi
H
Lacour
Bernard
B
Mebazaa
Abderraouf
A
D000328:Adult; D000367:Age Factors; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D016231:Fluorescence Polarization Immunoassay; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000150:complications; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications*; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D012307:Risk Factors; D014416:Tunisia
D017270:Lipoprotein(a); D006710:Homocysteine; D005340:Fibrinogen; D002097:C-Reactive Protein