Biodistribution of 10B in a rat liver tumor model following intra-arterial administration of sodium borocaptate (BSH)/degradable starch microspheres (DSM) emulsion.
We reported that intra-arterial administration of borocaptate sodium (BSH)/lipiodol emulsion provided selectively high (10)B concentrations (approximately 200 ppm 6 h after administration) in experimental liver tumors. In the present study, we investigated the pharmacokinetics of BSH following intra-arterial administration of BSH with other embolizing agent, degradable starch microspheres (DSM). The (10)B concentration in the tumor at 1 h after administration of BSH with DSM was 231 ppm. At 6 h, the (10)B concentration in the tumor in BSH with DSM group was 81.5 ppm. The (10)B concentration in the liver at 1 h after administration of BSH with DSM was 184 ppm. At 6 h, the(10)B concentration in the liver in BSH with DSM group was 78 ppm. The tumor/liver (10)B concentration ratios (T/L ratio) in the "BSH+DSM" group were significantly smaller than those in the "BSH+lipiodol" group at 1 h (1.4 vs. 3.6) and 6h (1.1 vs. 14.9). BSH/DSM-boron neutron capture therapy (BNCT) was not suitable for treatment of multiple liver tumors due to the low T/L (10)B concentration ratio. However, the high (10)B accumulation in the liver tumors following intra-arterial administration of BSH/DSM emulsion suggests that BSH/DSM-BNCT has the potential for application to malignant tumors in other sites.
Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan. msuzuki@rri.kyoto-u.ac.jp
Minoru
M
Suzuki
Kenji
K
Nagata
Shinichiro
S
Masunaga
Yuko
Y
Kinashi
Yoshinori
Y
Sakurai
Akira
A
Maruhashi
Koji
K
Ono
D000818:Animals; D001894:Borohydrides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D001895:Boron / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy; D002279:Carcinoma 256, Walker / Q000378:metabolism* / Q000532:radiotherapy*; D004655:Emulsions; D005260:Female; D007459:Iodized Oil / Q000008:administration & dosage; D007554:Isotopes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000532:radiotherapy*; D008863:Microspheres; D051381:Rats; D017208:Rats, Wistar; D013213:Starch; D013438:Sulfhydryl Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution
D001894:Borohydrides; D004655:Emulsions; D007554:Isotopes; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D007459:Iodized Oil; D013213:Starch; D001895:Boron