[Deep sclerectomy using a hyaluronate implant versus trabeculectomy. A comparison of two glaucoma operations using mitomycin C].
BACKGROUND
It was investigated whether a very low target pressure could be achieved by modification of deep sclerectomy without losing the advantages of non penetrating surgery in comparison to conventional filtration surgery.


METHODS
A total of 22 eyes from 22 patients with advanced open angle glaucoma were randomly assigned to receive a deep sclerectomy or a trabeculectomy. Both groups received 0.02% mitomycin C under the conjunctiva prior to preparation of the scleral flap. In the deep sclerectomy group at least parts of the outer trabecular meshwork were removed until an apparent filtration was achieved. A dry cross-linked hyaluronate served as an implant. In the other group a classical trabeculectomy was performed.


RESULTS
The median intraocular pressure 12 months post-operation was 11.5 mm Hg in the deep sclerectomy group compared to 11 mm Hg in the trabeculectomy group; the median of the relative IOP reduction was -47% in the deep sclerectomy group, and -57% in the trabeculectomy group. The best corrected visual acuity was unchanged 12 months postoperatively in both groups.


CONCLUSIONS
As a more aggressive IOP-lowering procedure (intended filtration, use of antimetabolites) deep sclerectomy proved to be as effective as trabeculectomy. Nevertheless, the advantages of the more difficult surgical procedure concerning visual acuity, complications and surgical interventions were lost postoperatively.
Augenklinik der Johannes Gutenberg-Universität, Mainz. o.schwenn@buergerhospital-ffm.de
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Schwenn
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Springer
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Troost
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Yun
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Pfeiffer
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003886:Descemet Membrane / Q000601:surgery*; D005260:Female; D018463:Filtering Surgery; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D006820:Hyaluronic Acid; D007429:Intraocular Pressure / Q000502:physiology; D032801:Iridectomy; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000209:etiology*; D019919:Prosthesis Implantation; D012590:Sclera / Q000601:surgery*; D014129:Trabecular Meshwork / Q000601:surgery*; D014130:Trabeculectomy; D014792:Visual Acuity / Q000502:physiology
D016685:Mitomycin; D006820:Hyaluronic Acid