Formation and differentiation of the avian sclerotome.
The avian sclerotome forms by epitheliomesenchymal transition of the ventral half-somite. Sclerotome development is characterized by a craniocaudal polarization, resegmentation, and axial identity. Its formation is controlled by signals from the notochord, the neural tube, the lateral plate mesoderm, and the myotome. These signals and crosstalk between somite cells lead to the separation of various subdomains, such as the central and ventral sclerotomes that express Pax1 under the control of Sonic hedgehog and Noggin, and the dorsal and lateral sclerotome that do not express Pax1 and are controlled by Bmp-4. Further subdomains that give rise to specific derivatives are the syndetome, neurotome, meningotome, and arthrotome. The molecular control of subdomain formation and cell type specification is discussed.
Christ
Bodo
B
Institute of Anatomy and Cell Biology II, University of Freiburg, Albertstrasse 17, Freiburg, Germany. bodo.christ@anat.uni-freiburg.de
Huang
Ruijin
R
Scaal
Martin
M
D000818:Animals; D001717:Birds / Q000196:embryology*; D019521:Body Patterning / Q000502:physiology*; D001846:Bone Development / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002642:Chick Embryo; D002645:Chickens; D003370:Coturnix; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D051761:Paired Box Transcription Factors; D019170:Somites / Q000166:cytology / Q000378:metabolism*; D013131:Spine / Q000196:embryology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D051761:Paired Box Transcription Factors; D014157:Transcription Factors; C070835:PAX1 transcription factor