A practical method for the stereoselective generation of beta-2-deoxy glycosyl phosphates.
Beta-2-Deoxy sugar nucleotides are substrates used by a variety of glycosyltransferases (Gtfs). We have developed a chemical route to synthesize beta-2-deoxy sugar phosphates that starts from alpha-glycosyl chlorides. Our approach reliably provides access to a range of NDP beta-2-deoxy sugars essential for studying glycosyltransferases involved in the synthesis of biologically active natural products.
Oberthür
Markus
M
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Leimkuhler
Catherine
C
Kahne
Daniel
D
D016695:Glycosyltransferases / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013403:Sugar Phosphates / Q000138:chemical synthesis*
D013403:Sugar Phosphates; D016695:Glycosyltransferases