Magnetoresistive-based biosensors and biochips.
Over the past five years, magnetoelectronics has emerged as a promising new platform technology for biosensor and biochip development. The techniques are based on the detection of the magnetic fringe field of a magnetically labeled biomolecule interacting with a complementary biomolecule bound to a magnetic-field sensor. Magnetoresistive-based sensors, conventionally used as read heads in hard disk drives, have been used in combination with biologically functionalized magnetic labels to demonstrate the detection of molecular recognition. Real-world bio-applications are now being investigated, enabling tailored device design, based on sensor and label characteristics. This detection platform provides a robust, inexpensive sensing technique with high sensitivity and considerable scope for quantitative signal data, enabling magnetoresistive biochips to meet specific diagnostic needs that are not met by existing technologies.
Graham
Daniel L
DL
Institute of Engineering of Systems and Computers-Microsystems and Nanotechnologies (INESC-MN), Rua Alves Redol 9, Lisbon 1000-029, Portugal. dgraham@inesc-mn.pt
Ferreira
Hugo A
HA
Freitas
Paulo P
PP
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D001710:Biotin / Q000737:chemistry; D015342:DNA Probes / Q000737:chemistry / Q000235:genetics; D017097:Electric Impedance; D005290:Ferric Compounds / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D008280:Magnetics; D046208:Microchip Analytical Procedures / Q000379:methods*; D008863:Microspheres; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology; D009693:Nucleic Acid Hybridization / Q000379:methods; D019809:Streptavidin / Q000737:chemistry
D015342:DNA Probes; D005290:Ferric Compounds; C000499:ferric oxide; D001710:Biotin; D019809:Streptavidin