IL-10 gene polymorphisms in infectious disease and SIDS.
Interleukin-10 (IL-10) is a regulatory cytokine, and its principal role in vivo is to limit inflammatory response. IL-10 has been shown to influence both the susceptibility and course of various diseases, and the different polymorphisms in the IL-10 gene promoter have been associated with disease prevalence and severity. The genes involved in the immune system are also assumed to be of importance with regard to sudden infant death syndrome (SIDS), and specific haplotypes in the IL-10 gene promoter have been reported associated both with SIDS and sudden unexpected death due to infection.
Institute of Forensic Medicine, Rikshospitalet University Hospital, 0027 Oslo, Norway. s.h.opdal@labmed.uio.no
Siri Hauge
SH
Opdal
D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007239:Infections / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D013398:Sudden Infant Death / Q000235:genetics*
D016753:Interleukin-10