Total synthesis of (-)-strychnine.
Total synthesis of (-)-strychnine is described. Notable features of our synthesis include (1) palladium-catalyzed coupling of the indole and vinyl epoxide moieties, (2) synthesis of the nine-membered cyclic amine derivative from the diol precursor in a one-pot procedure, and (3) transannular cyclization of the nine-membered cyclic amine.
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yosuke
Y
Kaburagi
Hidetoshi
H
Tokuyama
Tohru
T
Fukuyama
D011042:Poisons / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013331:Strychnine / Q000138:chemical synthesis* / Q000737:chemistry
D011042:Poisons; D013331:Strychnine