[Effect of Chinese drugs for jianpi huayu on healing quality of gastric ulcer in rats].
OBJECTIVE
To observe the effect of Chinese drugs of Jianpi Huayu (JPHY, strengthening Pi and dissolving stasis) on healing quality of gastric ulcer and its mechanism.


METHODS
The gastric ulcer model was established by subserous injection of ethanoic acid in rats. Rats were randomly divided into 4 groups, the blank group, the model group, the ranitidine (RT) group and the JPHY group. Quantity of regenerative mucosa of healed gastric ulcer was determined using HE stain, epidermal growth factor (EGF) content in serum and stomach mucosa was detected by RIA and epidermal growth factor receptor (EGFR) protein expression was determined by immunohistochemistry.


RESULTS
Thickness of regenerated mucosa in the CHM group was higher than that in the model group and the RT group (P<0.05 or P<0.01); EGF content in mucosa in the JPHY group and the RT group was higher than that in the model group (P<0.01) and EGFR protein expression in the JPHY group was higher than that in the model group (P<0.05).


CONCLUSIONS
JPHY could improve the proliferation of epithelial cells, inhibit gastric acid, improve microcirculation of gastric mucosa through the mediation of EGFR, so as to elevate the healing quality of gastric ulcer, display its anti-ulcer action.
Liu
Jian-ping
JP
Hebei Medical University, Shijiazhuang 050011. liujianping0311@yahoo.com.cn
Hu
Dong-ju
DJ
Zong
Quan-he
QH
Chen
Zhiqiang
Z
Niu
Bingzhan
B
D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology*
D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D019342:Acetic Acid