Intramolecular C-N bond addition of amides to alkynes using platinum catalyst.
The intramolecular aminoacylation of alkynes using ortho-alkynylacetanilides proceeds in very high yields in the presence of PtCl2 catalyst. This reaction provides not only a useful procedure for synthesizing 2,3-disubstituted indoles at once from ortho-alkynylaniline derivatives, but also an interesting mechanistic aspect; the intramolecular C-N bond addition of amides to alkynes takes place readily in the presence of Pt(II) catalyst.
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Tomohiro
T
Shimada
Itaru
I
Nakamura
Yoshinori
Y
Yamamoto