First BNCT treatment of a skin melanoma in Argentina: dosimetric analysis and clinical outcome.
A Phase I/II protocol for treating cutaneuos melanomas with BNCT was designed in Argentina by the Comisión Nacional de Energía Atómica and the medical center Instituto Roffo. The first of a cohort of thirty planned patients was treated on October 9, 2003. This article depicts the protocol-based procedure and describes the first clinical case, treatment regime and planning, patient irradiation, retrospective dosimetric analysis and clinical outcome. Considering the low acute skin toxicity and the complete response in 21 of the 25 subcutaneous melanoma nodules treated, a second irradiation was performed in a different location of the extremity of the same patient. The corresponding clinical outcome is still under evaluation.
González
S J
SJ
Comisión Nacional de Energía Atómica, Av. Del Libertador 8250, (1429) Ciudad de Buenos Aires, Argentina. srgonzal@cnea.gov.ar
Bonomi
M R
MR
Santa Cruz
G A
GA
Blaumann
H R
HR
Calzetta Larrieu
O A
OA
Menéndez
P
P
Jiménez Rebagliati
R
R
Longhino
J
J
Feld
D B
DB
Dagrosa
M A
MA
Argerich
C
C
Castiglia
S G
SG
Batistoni
D A
DA
Liberman
S J
SJ
Roth
B M C
BM
D001118:Argentina; D001895:Boron / Q000097:blood / Q000493:pharmacokinetics; D001896:Boron Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods; D002985:Clinical Protocols; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000532:radiotherapy* / Q000556:secondary; D008875:Middle Aged; D011880:Radiotherapy Planning, Computer-Assisted; D012878:Skin Neoplasms / Q000378:metabolism / Q000532:radiotherapy* / Q000556:secondary; D016896:Treatment Outcome
C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D005632:Fructose; D001895:Boron