Fixed drug eruption from piroxicam.
The pathogenetic mechanism of fixed drug eruption (FDE) is still unknown. One of the most common causes of FDE is the use of nonsteroidal antiinflammatory drugs (NSAIDs). Oxicams are in the NSAID group and piroxicam is one of the most used of these drugs. FDE caused by piroxicam is rare but a few cases have been reported. Patch tests are useful for diagnosing some cases of FDE; they give variable results on previously affected skin while no reaction appears on unaffected skin. Some cases of cross-sensitivity among piroxicam and other substances have been reported. We report two new cases of FDE due to piroxicam with negative patch test on normal skin and positive results on affected skin.
Department of Dermatology, Hospital Juan Canalejo, C/Xubias de Arriba 84, 15006 A Coruña, Spain.
E
E
Cuerda Galindo
J J
JJ
Goday Buján
J M
JM
García Silva
W
W
Martínez
M
M
Verea Hernando
E
E
Fonseca
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004550:Elbow; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D010328:Patch Tests; D010894:Piroxicam / Q000008:administration & dosage / Q000009:adverse effects*; D012216:Rheumatic Diseases / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam