Invasive Streptococcus pneumoniae in France: antimicrobial resistance, serotype, and molecular epidemiology findings from a monthly national study in 2000 to 2002.
A study of 257 French invasive pneumococci isolated between 2000 and 2002 showed high rates of nonsusceptibility to penicillin and macrolides (50%), contrasting with a low frequency of resistance to amoxicillin or levofloxacin (<1%) and tolerance to vancomycin (0%). The genetic homogeneity of some serogroups, including serogroup 1, enhanced the risk of epidemiological changes.
Decousser
Jean-Winoc
JW
Centre Hospitalier de Versailles André Mignot, Service d'Hygiène Hospitalière, 177 rue de Versailles, 78157 Le Chesnay Cedex, France. JWDECOUSSER@ch-versailles.fr
Pina
Patrick
P
Viguier
Florent
F
Picot
Franc
F
Courvalin
Patrice
P
Allouch
Pierre
P
D000328:Adult; D000658:Amoxicillin / Q000494:pharmacology; D002648:Child; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005602:France / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D011159:Population Surveillance; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
D000658:Amoxicillin