Improvement of the dissolution rate of silymarin by means of solid dispersions.
Solid dispersions of silymarin were prepared by the fusion method with the intention of improving the dissolution properties of silymarin. Polyethylene glycol 6000 (PEG 6000) was used as the inert hydrophilic matrix. The dissolution studies of the solid dispersions were performed in vitro. And the results obtained showed that the dissolution rate of silymarin was considerably improved when formulated in solid dispersions with PEG 6000 as compared to original drug, and the increased dissolution rate might be favorable for further oral absorption.
Department of Pharmaceutical Sciences, Changhai Hospital, Second Military Medical University, Shanghai, China.
Feng-Qian
FQ
Li
Jin-Hong
JH
Hu
D000042:Absorption; D002626:Chemistry, Pharmaceutical; D011092:Polyethylene Glycols / Q000737:chemistry*; D012838:Silymarin / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013997:Time Factors; D014867:Water / Q000737:chemistry
D012838:Silymarin; D014867:Water; D011092:Polyethylene Glycols