Caprine hepatic lipidosis induced through the intake of low levels of dietary cobalt.
Forty-one, 10-week-old newly weaned goats were randomly allocated into two groups, namely control (n=22) and treated (n=19). Kids in both groups were fed Rhodegrass hay ad libitum that contained < 0.1 mg/kg DM cobalt and 150 g/day of a commercially prepared ruminant concentrate that contained approximately 0.12 mg/kg DM cobalt. This diet provided the minimum daily requirement of cobalt as specified for sheep. The treated goats were supplemented with bi-monthly subcutaneous injections of 2000 microg of hydroxycobalamin. All goats were weighed and blood samples collected monthly for haematological, clinical biochemical and serum vitamin B12 analysis. After a 10-month experimental period the goats were slaughtered. The control animals exhibited significantly (P<0.05) lower weight gains, and had dry scruffy hair coats. In addition, there was a decline in erythrocyte counts, mean haemoglobin, packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration. Controls also exhibited significantly (P<0.05) lower levels of total serum proteins and elevated levels of serum alkaline phosphatase compared to treated goats. Fourteen (63.6%) of the control goats developed pathology consistent with reported field cases of hepatic lipidosis associated with low liver levels of cobalt. Only one (5.3%) of the treated goats developed hepatic lipidosis. Contrary to previous reports that suggested that goats are less sensitive to low levels of dietary cobalt than sheep, it is apparent that this is not the case with Omani goats. This is the first report of the induction of hepatic lipidosis in goats due to feeding low levels of cobalt in their diet.
Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, P.O. Box 34, Al-Khod 123, Muscat, Sultanate of Oman. ejohnson@squ.edu.om
Eugene H
EH
Johnson
Khalid
K
Al-Habsi
Evelyn
E
Kaplan
Anandarajah
A
Srikandakumar
Isam T
IT
Kadim
Kanthi
K
Annamalai
Rashid
R
Al-Busaidy
Osman
O
Mahgoub
D000818:Animals; D001835:Body Weight; D003035:Cobalt / Q000008:administration & dosage / Q000172:deficiency*; D003677:Deficiency Diseases / Q000097:blood / Q000662:veterinary*; D004032:Diet; D015511:Goat Diseases / Q000097:blood*; D006041:Goats; D008064:Lipidoses / Q000097:blood / Q000662:veterinary*; D008107:Liver Diseases / Q000097:blood / Q000662:veterinary*
D003035:Cobalt