A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates.
Fusidic acid-resistant epidemic Staphylococcus aureus strains causing impetigo bullosa have been reported in Scandinavia. We show that these strains form part of a European epidemic clonotype that carries the fusB determinant. In contrast, resistance to fusidic acid in a collection of nonepidemic strains resulted primarily from mutations in fusA.
Antimicrobial Research Centre and School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK.
Alexander J
AJ
O'Neill
Anders R
AR
Larsen
Anne S
AS
Henriksen
Ian
I
Chopra
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D017931:DNA Primers; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005060:Europe / Q000453:epidemiology; D005672:Fusidic Acid / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D007169:Impetigo / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D005810:Multigene Family; D009154:Mutation / Q000235:genetics; D020653:Peptide Elongation Factor G / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D017931:DNA Primers; D004269:DNA, Bacterial; C492444:FusA protein, Staphylococcus aureus; C492443:FusB protein, Staphylococcus aureus; D020653:Peptide Elongation Factor G; D005672:Fusidic Acid