General approach to polycyclic meroterpenoids based on stille couplings and titanocene catalysis.
We describe a novel convergent procedure that has proved useful in the synthesis of a wide range of meroterpenoid-related structures containing a mono-, sesqui-, or diterpenoid moiety linked to a nonfused aromatic subunit with various substitution patterns. The key steps were the Stille-type coupling of aryl stannanes and allylic carbonates, followed by the titanocene-catalyzed domino cyclization of aryl epoxypolyprenes. The coupling reaction was perfectly compatible with preformed epoxides, while the sequential cyclization, which presumably proceeded via alkyl radicals inert to benzene derivatives, selectively provided exocyclic alkenes.
Justicia
José
J
Department of Organic Chemistry, Faculty of Sciences, University of Granada, E-18071 Granada, Spain.
Oltra
J Enrique
JE
Cuerva
Juan M
JM
D002384:Catalysis; D003500:Cyclization; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000737:chemistry*
D007202:Indicators and Reagents; D039821:Monoterpenes; D009942:Organometallic Compounds; C406884:titanocene