In vivo model for dyslipidemia with diabetes mellitus in hamster.
Due to similarities in lipid metabolism to those in humans, hamster is considered as a good model for the study of regulatory mechanisms of plasma lipoproteins in response to cholesterol or fatty acid-enriched diet. This model of hyperlipidemia has been modified to produce dyslipidedmia with diabetes complexities by feeding with high fat diet added with 9% (w/w) fructose. Feeding this diet to hamster for 10 days markedly increases plasma levels of triglyceride, cholesterol, fatty acids followed by a significant increase in glycerol, beta lipoproteins, high density lipoprotein, glucose and glycosylated proteins. This model is being used for research and development of lipid lowering drugs with hypoglycemic activity in collaboration with Novo Nordisk, Denmark. The modified high fat diet formulation has now been prepared (Research diet D.99122211) and supplied by Research Diets Inc, Burnswick USA.
Division of Biochemistry & Toxicology, Central Drug Research Institute, Lucknow, 226001, India.
Gitika
G
Bhatia
Farhan
F
Rizvi
Rashmi
R
Saxena
Anju
A
Puri
A K
AK
Khanna
Ramesh
R
Chander
E M
EM
Wulff
A K
AK
Rastogi
D000818:Animals; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D011345:Fenofibrate / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000150:complications* / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use
D004041:Dietary Fats; D000960:Hypolipidemic Agents; D011345:Fenofibrate