Biodistribution studies of boronophenylalanine-fructose in melanoma and brain tumor patients in Argentina.
A study of the (10)B-enriched p-boronophenylalanine-fructose complex ((10)BPA-F) infusion procedure in potential BNCT patients, including four melanoma of extremities and two high-grade gliomas (glioblastoma and ganglioglioma) was performed. T/B and S/B ratios for (10)B concentrations in tumor (T), blood (B) and skin (S) were determined. The T/B ratio for the glioblastoma was in the 1.8-3.4 range. The ganglioglioma did not show any significant boron uptake. For the nodular metastasic melanoma T/B values were between 1.5 and 2.6 (average 2.1+/-0.4), corresponding to the lower limit of the mean values reported for different melanoma categories. This result might suggest a lower boron uptake for nodular metastasic melanomas. S/B was 1.5+/-0.4. An open two-compartment pharmacokinetic model was applied to predict the boron concentration during the course and at the end of a BNCT irradiation.
Comisión Nacional de Energía Atómica (CNEA), Avda. del Libertador 8250, 1429 Buenos Aires, Argentina. liberman@cnea.gov.ar
S J
SJ
Liberman
A
A
Dagrosa
R A
RA
Jiménez Rebagliati
M R
MR
Bonomi
B M
BM
Roth
L
L
Turjanski
S I
SI
Castiglia
S J
SJ
González
P R
PR
Menéndez
R
R
Cabrini
M J
MJ
Roberti
D A
DA
Batistoni
D000328:Adult; D000368:Aged; D001118:Argentina; D001895:Boron / Q000097:blood / Q000493:pharmacokinetics; D001896:Boron Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D018303:Ganglioglioma / Q000378:metabolism / Q000532:radiotherapy; D005909:Glioblastoma / Q000378:metabolism / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000532:radiotherapy* / Q000556:secondary; D008875:Middle Aged
C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D005632:Fructose; D001895:Boron