Quantitative effects of palivizumab and donor-derived T cells on chronic respiratory syncytial virus infection, lung disease, and fusion glycoprotein amino acid sequences in a patient before and after bone marrow transplantation.
A patient with respiratory syncytial virus (RSV) infection and severe combined immunodeficiency was studied during a 3-month period of bone marrow transplantation and palivizumab infusion. No RSV isolates with palivizumab escape mutations were identified. Donor lymphocytes, including CD8 cells, appeared to markedly reduce the RSV load but increased the pulmonary symptoms. Immunosuppressive therapy ameliorated lung disease but allowed the RSV load to rebound.
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. chadi.elsaleeby@stjude.org
C M
CM
El Saleeby
J
J
Suzich
M E
ME
Conley
J P
JP
DeVincenzo
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000378:metabolism / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D016026:Bone Marrow Transplantation / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D018655:Lymphocyte Count; D008297:Male; D000069455:Palivizumab; D011024:Pneumonia, Viral / Q000276:immunology*; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000628:therapy* / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*; D016511:Severe Combined Immunodeficiency / Q000150:complications / Q000628:therapy; D013601:T-Lymphocytes / Q000502:physiology*; D014760:Viral Fusion Proteins / Q000378:metabolism
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D014760:Viral Fusion Proteins; C098685:respiratory syncytial virus immune globulin intravenous; D000069455:Palivizumab