[Antizonal antibodies in ovulatory cervical mucus and in serum of patients with fertility disorders].
OBJECTIVE
Detection of antizonal antibodies (aZPs) in cervical ovulatory mucus and in serum in patients with fertility failure.


METHODS
Retrospective study.


METHODS
Department of Gynaecology and Obstetrics, Medical Faculty of Charles University, and Faculty Hospital, Plzen.


METHODS
Detection of aZPs (passive hemagglutination test) in cervical ovulatory mucus (OM) and in serum from 105 patients with reproductive failure and in 25 fertile healthy women (control group).


RESULTS
Positive levels of aZP in OM were found in 79 (75.2%) patients, in 56 of them aZP were observed in OM and in serum together, only ovulatory aZPs in 23 (21.9%), and only serum aZPs in 18 (17.1%) were found. aZPs predominate in 47 patients (of 48 women) with more than two in vitro fertilization processes, in thirty of them aZPs in serum and in OM together were observed. On the other hand, repeated spontaneous miscarriage and obesity have no connection with detection of aZPs in our patients. CONCLUSION. The increased levels of serum and OM aZPs are very often seen in patients after repeated unsuccessful IVF. This very important result in reproductive immunology means to go on the micromanipulation technics combined with immunosuppression in the next planned IVF procedure.
Gynekologicko-porodnická klinika LF UK a FN, Plzen.
Z
Z
Ulcová-Gallová
K
K
Babcová
P
P
Nováková
Z
Z
Micanová
Z
Z
Rokyta
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002582:Cervix Mucus / Q000276:immunology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000276:immunology*; D010060:Ovulation; D011247:Pregnancy; D015044:Zona Pellucida / Q000276:immunology*
D001323:Autoantibodies