Coronary flow velocity reserve does not correlate with TIMI frame count in patients undergoing non-emergency percutaneous coronary intervention.
OBJECTIVE
The purpose of this research was to compare the Thrombolysis In Myocardial Infarction (TIMI) frame count (CTFC) with coronary flow velocity reserve (CFVR) in patients undergoing percutaneous coronary intervention (PCI).


BACKGROUND
The relationship between CTFC and CFVR has not been adequately assessed in patients with coronary artery disease.


METHODS
We studied 62 patients who underwent successful non-emergent PCI. All patients had Doppler evaluation of CFVR, CTFC, and quantitative coronary angiography. In an additional 17 patients, a frame count reserve was calculated as baseline CTFC/CTFC at peak hyperemia, induced by intracoronary adenosine after PCI.


RESULTS
The CTFC decreased from 27 +/- 13 to 18 +/- 8, and CFVR increased from 1.5 +/- 0.4 to 2.6 +/- 0.7 (both p < 0.0001). The pre-PCI CTFC and the CFVR were closely related to minimal lumen diameter (p < 0.0001). After PCI, there was no correlation between CFVR and CTFC. In addition, no relationship was observed between CFVR and the frame count reserve.


CONCLUSIONS
There was no significant correlation between CFVR and CTFC in patients undergoing coronary intervention. The relative utility of these measures in predicting outcomes in this setting requires further evaluation, but CTFC (or frame count reserve) does not appear to be an adequate surrogate measure of Doppler-derived CFVR.
Department of Cardiovascular Sciences, University of Calgary, Calgary, Canada.
Sanjay K
SK
Chugh
Jennifer
J
Koppel
Mark
M
Scott
Lana
L
Shewchuk
David
D
Goodhart
Raoul
R
Bonan
Jean-Claude
JC
Tardif
Stephen G
SG
Worthley
Carlo
C
DiMario
Michael J
MJ
Curtis
Ian T
IT
Meredith
Todd J
TJ
Anderson
D000241:Adenosine; D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity; D003097:Collateral Circulation; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D014463:Ultrasonography
D000241:Adenosine