Effects of fimbria-fornix, hippocampus, and amygdala lesions on discrimination between proximal locations.
The conditioned cue preference (CCP) task was used to study the information required to discriminate between spatial locations defined by adjacent arms of an 8-arm radial maze. Normal rats learned the discrimination after 3 unreinforced preexposure (PE) sessions and 4 food paired-unpaired training trials. Fimbria-fornix lesions made before, but not after, PE, and hippocampus lesions made at either time, blocked the discrimination, suggesting that the 2 structures processed different information. Lateral amygdala lesions made before PE facilitated the discrimination. This amygdala-mediated interference with the discrimination was the result of a conditioned approach response that did not discriminate between the 2 arm locations. A hippocampus/fimbria-fornix system and an amygdala system process different information about the same learning situation simultaneously and in parallel.
Chai
Sin-Chee
SC
Department of Psychology, McGill University, Montreal, PQ, Canada. schai@gate.sinica.edu.tw
White
Norman M
NM
D000679:Amygdala / Q000293:injuries / Q000502:physiology; D000818:Animals; D001927:Brain Diseases / Q000503:physiopathology; D002755:Choice Behavior; D003213:Conditioning, Psychological / Q000502:physiology*; D003463:Cues; D004193:Discrimination Learning / Q000502:physiology*; D020712:Fornix, Brain / Q000293:injuries / Q000502:physiology; D006624:Hippocampus / Q000293:injuries / Q000502:physiology; D008032:Limbic System / Q000293:injuries / Q000503:physiopathology*; D018782:Maze Learning; D016202:N-Methylaspartate / Q000633:toxicity; D009498:Neurotoxins / Q000633:toxicity; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000502:physiology; D012054:Reinforcement, Psychology; D013028:Space Perception / Q000502:physiology*
D009498:Neurotoxins; D016202:N-Methylaspartate