[Role of a transforming growth factor beta-1 in regulation of invasive growth of prostatic adenocarcinoma].
Immunohistochemical study of histological sections and immunochemical study in supernatants of primary cultures demonstrated a marked increase of the factor production in the regions of the background changes outside foci of carcinoma invasive growth. There was no difference in the type of expression of TGFbeta-I and TGFbeta-II receptors in morphologically different regions of the tumour. TGFbeta-I is considered as a principal factor that mediates hyperplastic reaction of the stroma in prostatic adenocarcinoma outside the zones of invasive growth. Formation of reactive stroma, in the authors' opinion, plays the role of a defensive mechanism hindering invasion of tumour cells into the connective tissue and its progression.
O P
OP
Gladskikh
T I
TI
Danilova
A B
AB
Kuznetsova
A A
AA
Ivanov
Iu Iu
IuIu
Andreeva
B Ia
BIa
Alekseev
G A
GA
Frank
M A
MA
Pal'tsev
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D000818:Animals; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1
D018125:Receptors, Transforming Growth Factor beta; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1