The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study.
The nitric oxide (NO) scavenging activities of traditional polyherbal drugs like abana, chyavanaprasha, geriforte, septilin, mentat and triphala were examined using sodium nitroprusside as a NO donor in vitro. All the drugs tested demonstrated direct scavenging of NO and were superior to Gingko biloba, which was used as a positive control. The extracts of various polyherbal drugs exhibited dose-dependent NO scavenging activities and the potency was in the following order: abana > chyavanaprasha > triphala > geriforte > septilin > mentat > Gingko biloba. The present results suggest that the traditional Indian polyherbal crude drugs may be potent and novel therapeutic agents for scavenging of NO, and thereby inhibit the pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite. These findings may also help to explain, at least in part, the pharmacological activities like rejuvenating, adaptogenic, anti-infection, anti-inflammatory, cardioprotective and neuroprotective activities of these traditional, clinically used non toxic drugs.
Department of Radiobiology, Kasturba Medical College, Manipal, India. gc.jagetia@kmc.manipal.edu
Ganesh Chandra
GC
Jagetia
Shaival Kamalaksh
SK
Rao
Manjeshwar Shrinath
MS
Baliga
Kiran
K
S  Babu
D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020441:Ginkgo biloba; D006801:Humans; D007194:India; D008519:Medicine, Traditional; D009569:Nitric Oxide / Q000378:metabolism*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal
D016166:Free Radical Scavengers; C074754:Mentat; D010936:Plant Extracts; C047352:septilin; C064613:abana; D009569:Nitric Oxide; C047351:geriforte