[A clinical and pathothysiological study of protein C in patients with generalized meningococcosis].
The clinical-and-pathogenetic significance of protein C was dynamically investigated within the infection processes in 23 patients (mean age 44 years) with meningococcemia. A reliably lower concentration of protein C in blood plasma (mean 37.8%) was registered versus the normal parameters (N = 70-130%) at exacerbation irrespective of a disease outcome. Leyden mutation was detected in 30.5% of patients. The presence of the above genetic defect denoted a predisposition to a severe disseminated intravascular coagulation (DIC) syndrome in patients of the studied group. A lower concentration of protein C was detected in blood plasma of patients with meningococcemia; it correlated with severity of the infection process and with the development of organic malfunction. The study of the concentration of protein C enabled an evaluation of the functional condition of anticoagulation mechanisms in the DIC development and can be regarded as an important extra criterion for the evaluation of thrombohemorrhagic syndrome in patients with meningococcemia.
E A
EA
Gorodnova
S G
SG
Pak
V A
VA
Malov
S V
SV
Grachev
V B
VB
Beloborodov
D000293:Adolescent; D000328:Adult; D000368:Aged; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000209:etiology; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D011486:Protein C / Q000032:analysis*; D020151:Protein C Deficiency / Q000150:complications
D011486:Protein C