Kinetics of immune parameters in a patient with sepsis caused by Streptococcus pyogenes treated with activated protein C.
We report a case of streptococcal sepsis treated with recombinant human activated protein C (rhAPC). High plasma IL-6 and cortisol levels at baseline significantly decreased 24 h following the infusion of rhAPC. This decrease was accompanied by a rise of circulating lymphocyte subsets. Our observation may be due to immunomodulatory properties of rhAPC.
Third Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague, Czech Republic. michal.holub@fnb.cz
Michal
M
Holub
Miroslav
M
Helcl
Ondrej
O
Beran
Jarmila
J
Hnyková
Jana
J
Príhodová
D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007700:Kinetics; D008875:Middle Aged; D011486:Protein C / Q000008:administration & dosage / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology* / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000276:immunology* / Q000382:microbiology; D013297:Streptococcus pyogenes; D016896:Treatment Outcome
D015850:Interleukin-6; D011486:Protein C; D011994:Recombinant Proteins; D006854:Hydrocortisone