[Monitoring of IL-6 levels in patients after total hip joint replacement].
Total hip replacement became a method of choice in treatment of the severe osteoarthritis. Despite the progress in constructing the implants and also the surgical technique, the number of complications rises together with the number of arthroplasties performed. The periprosthetic osteolysis and its consequence--the loosening is the one of the greatest problems of today's joint replacement. It creates the main obstacle for the long-term efficiency of the total hip arthroplasty. It was proved by the numerous research, wear debris of the implant induce the chronic periprosthetic inflammatory process. Many studies emphasize the influence of the proinflammatory cytokines on the bone metabolism. The aim of the study was the evaluation of the inflammatory process in patients with the severe osteoarthritis before the surgery and in subsequent periods after total hip replacements and also in patients with the aseptic loosening of the endoprosthesis, by the monitoring the levels of IL-6 in serum of the peripheral blood. The results suggest, that in patients following THA with the elevated level of IL-6, the inflammatory process was present. This inflammation may lead in future to the aseptic loosening of the implant.
Woźniak
Waldemar
W
Katedra i Klinika Ortopedii, Akademia Medyczna im. Karola Marcinkowskiego w Poznaniu.
Wierusz-Kozłowska
Małgorzata
M
Markuszewski
Jacek
J
Leśniewska
Kinga
K
Wiktorowicz
Krzysztof
K
D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001207:Asepsis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000276:immunology / Q000601:surgery*; D010014:Osteolysis / Q000276:immunology*; D016459:Prosthesis-Related Infections / Q000276:immunology*; D013997:Time Factors
D015850:Interleukin-6