Magnetoresistive-based biosensors and biochips.
Over the past five years, magnetoelectronics has emerged as a promising new platform technology for biosensor and biochip development. The techniques are based on the detection of the magnetic fringe field of a magnetically labeled biomolecule interacting with a complementary biomolecule bound to a magnetic-field sensor. Magnetoresistive-based sensors, conventionally used as read heads in hard disk drives, have been used in combination with biologically functionalized magnetic labels to demonstrate the detection of molecular recognition. Real-world bio-applications are now being investigated, enabling tailored device design, based on sensor and label characteristics. This detection platform provides a robust, inexpensive sensing technique with high sensitivity and considerable scope for quantitative signal data, enabling magnetoresistive biochips to meet specific diagnostic needs that are not met by existing technologies.
Institute of Engineering of Systems and Computers-Microsystems and Nanotechnologies (INESC-MN), Rua Alves Redol 9, Lisbon 1000-029, Portugal. dgraham@inesc-mn.pt
Daniel L
DL
Graham
Hugo A
HA
Ferreira
Paulo P
PP
Freitas
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D001710:Biotin / Q000737:chemistry; D015342:DNA Probes / Q000737:chemistry / Q000235:genetics; D017097:Electric Impedance; D005290:Ferric Compounds / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D008280:Magnetics; D046208:Microchip Analytical Procedures / Q000379:methods*; D008863:Microspheres; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology; D009693:Nucleic Acid Hybridization / Q000379:methods; D019809:Streptavidin / Q000737:chemistry
D015342:DNA Probes; D005290:Ferric Compounds; C000499:ferric oxide; D001710:Biotin; D019809:Streptavidin