A palladium-catalyzed enantioselective alkylative desymmetrization of meso-succinic anhydrides.
Monoalkylation of cyclic anhydrides provides an opportunity to couple a carbon-carbon bond-forming event with the control of backbone stereochemistry. We have developed a palladium-JOSIPHOS catalyst system that desymmetrizes meso-succinic anhydrides using organozinc reagents as nucleophiles, and have found that, in many cases, this reaction proceeds at ambient temperature.
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Eric A
EA
Bercot
Tomislav
T
Rovis