A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus.
A novel ll,20: 1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal 1 (1), was isolated from Isodan japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, P. R. China.
Quanbin
Q
Han
Jixia
J
Zhang
Yang
Y
Lu
Yunshan
Y
Wu
Qitai
Q
Zheng
Handong
H
Sun
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004988:Ethers, Cyclic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D037602:Isodon; D020014:K562 Cells / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D004988:Ethers, Cyclic; D010936:Plant Extracts; C005287:oxetane