Granulocyte, macrophage, monocyte apheresis for refractory ulcerative proctitis.
Refractory ulcerative colitis that fails conventional intense medical treatment often leads to colectomy. Although ciclosporin and infliximab may avert colectomy in certain cases, these treatments come with substantial toxicity and may only act as a bridge to avert emergency surgery. Granulocyte monocyte/macrophage adsorption apheresis is a new treatment and has shown efficacy for refractory colitis in up to 80% of cases in a Japanese study and is apparently only associated with negligible side effects. We report a case of severe refractory proctitis destined for colectomy effectively treated with granulocyte monocyte/macrophage adsorption apheresis. After two of five sessions the patient achieved full clinical remission, which has been sustained with the addition of azathioprine for more than 1 year.
Premchand
Purushothaman
P
Department of Gastroenterology, Guy's School of Medicine, London SE5 9PJ, UK. purushothaman.premchand@gstt.nhs.uk
Takeuchi
Ken
K
Bjarnason
Ingvar
I
D000328:Adult; D003093:Colitis, Ulcerative / Q000628:therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D011349:Proctitis / Q000628:therapy*