Effects of permeable boundaries on the diffusion-attenuated MR signal: insights from a one-dimensional model.
The local magnetization distribution M(x,t) and the net MR signal S arising from a one-dimensional periodic structure with permeable barriers in a Tanner-Stejskal pulsed-field gradient experiment are considered. In the framework of the narrow pulse approximation, the general expressions for M(x,t) and S as functions of diffusion time and the bipolar field gradient strength are obtained and analyzed. In contrast to a system with impermeable boundaries, the signal S as a function of the b-value is modeled well as a bi-exponential decay not only in the short-time regime but also in the long-time regime. At short diffusion times, the local magnetization M(x,t) is strongly spatially inhomogeneous and the two exponential components describing S have a clear physical interpretation as two "population fractions" of the slow- and fast-diffusing quasi-compartments (pools). In the long-diffusion time regime, the two exponential components do not have clear physical meaning but rather serve to approximate a more complex functional signal form. The average diffusion propagator, obtained by means of standard q-space analysis procedures in the long-diffusion time regime is explored; its structure creates the deceiving appearance of a system with multiple compartments of different sizes, while in reality, it reflects the permeable nature of boundaries in a system with multiple compartments all of the same size.
Sukstanskii
A L
AL
Department of Radiology, Biomedical MR Laboratory, Washington University, One Brookings Drive, St. Louis, MO 63130, USA. alex@wuchem.wustl.edu
Yablonskiy
D A
DA
Ackerman
J J H
JJ
D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D008566:Membranes / Q000737:chemistry*; D008962:Models, Theoretical; D010539:Permeability