Microscopic polyangiitis sparing the kidneys in a long-term survivor after allogeneic bone marrow transplantation and graft-versus-host disease.
We report an unusual case of microscopic polyangiitis sparing the kidneys in a long-term survivor of allogeneic bone marrow transplantation. Clinical and pathologic studies revealed cutaneous leukocytoclastic vasculitis and isolated pulmonary capillaritis. Serological studies revealed "double positive": perinuclear antineutrophil cytoplasmic (P-ANCA) antibody testing with anti-myeloperoxidase (MPO) activity and anti-glomerular basement membrane (anti-GBM) antibody. The vasculitis has been successfully controlled with prednisone and cyclophosphamide.
Almoallim
Hani
H
Mary Pack Arthritis Centre, Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, Canada. hanialmoallim@hotmail.com
Patterson
A Caroline
AC
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000628:therapy*; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D012079:Renal Circulation / Q000502:physiology; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D019268:Antibodies, Antineutrophil Cytoplasmic; D003520:Cyclophosphamide; D011241:Prednisone