Hepatoprotective activity of Haridradi ghrita on carbon tetrachloride-induced liver damage in rats.
Haridradi ghrita, a ghee based polyherbal formulation, (50, 100, 200 and 300 mg/kg) significantly lowered marker enzymes (SGPT, SGOT, ALP) and bilirubin in serum and liver peroxide, superoxide dismutase and catalase in liver homogenate following CCl4 (0.7 ml/kg, ip) toxicity. The protective effect was further supported by reversal of CCl4 induced histological changes. The results demonstrate significant hepatoprotective action of H. ghrita in CCl4 damaged rats.
Satturwar
P M
PM
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur 440 010, India.
Fulzele
S V
SV
Joshi
S B
SB
Dorle
A K
AK
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004041:Dietary Fats / Q000032:analysis*; D015227:Lipid Peroxidation; D008099:Liver / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D004041:Dietary Fats; D002251:Carbon Tetrachloride