Antioxidant and cytotoxic activities of Retama raetam subsp. Gussonei.
The aim of this study was to evaluate the in vitro antioxidant and cytotoxic activities of the methanol extracts of Retama raetam subsp. gussonei leaves and seeds. The antioxidant activity of the extracts was assessed by means of two different tests: (1) bleaching of the stable 2,2-diphenyl-1-picrylhydrazil (DPPH) radical; and (2) lipid peroxidation of liposomes which were prepared from bovine brain extract. In both tests used leaves extract showed a significant antioxidant effect. The extract of leaves also demonstrated a good cytotoxic activity against COR-L23 (large cell carcinoma) cell line.
Department of Pharmaceutical Science, University of Calabria, Rende, Italy. filomena.conforti@unical.it
F
F
Conforti
G
G
Statti
R
R
Tundis
M R
MR
Loizzo
M
M
Bonesi
F
F
Menichini
P J
PJ
Houghton
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds; D045744:Cell Line, Tumor / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D012639:Seeds
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001713:Biphenyl Compounds; D008081:Liposomes; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl