Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models.
Highlights from a Fundación Juan March Interdisciplinary Meeting. CD8+ T cells (TCD8+) play a critical role in immunity to viruses. A central feature of antiviral TCD8+ responses is immunodominance: out of thousands of potential target peptides, only a handful generate measurable responses. A recent Fundación Juan March Meeting brought together scientists working on the various steps in antigen presentation and T cell biology that contribute to immunodominance, whose understanding is key to rationally developing vaccines meant to elicit effective antiviral TCD8+ responses.
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. jyewdell@nih.gov
Jonathan W
JW
Yewdell
Margarita
M
Del Val
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D000882:Haplorhini; D006801:Humans; D007113:Immunity, Innate; D016056:Immunodominant Epitopes / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D014765:Viral Vaccines / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000276:immunology*
D016056:Immunodominant Epitopes; D014765:Viral Vaccines