Biologic markers of exposure to chlorinated solvents.
This article presents the current knowledge and clinical applications of the use of biomarkers of exposure to the halogenated solvents 1,1,1 trichloroethane (methylchloroform), trichloroethylene, tetrachloroethylene (perchloroethylene), and 1,1 dichloroethylene (vinylidene chloride). Although some studies have shown that protein and DNA adducts may form with chlorinated hydrocarbons, their application has not been validated sufficiently to justify their use as biologic markers of exposure.
Waksman
Javier C
JC
University of Colorado Health Sciences Center Denver, CO, CO 80262, USA. Javier.Waksman@uchsc.edu
Phillips
Scott D
SD
D015415:Biomarkers; D004000:Dichloroethylenes / Q000032:analysis* / Q000493:pharmacokinetics; D004781:Environmental Exposure / Q000032:analysis*; D006801:Humans; D012997:Solvents / Q000032:analysis* / Q000493:pharmacokinetics; D013750:Tetrachloroethylene / Q000032:analysis* / Q000493:pharmacokinetics; D014240:Trichloroethanes / Q000032:analysis* / Q000493:pharmacokinetics
D015415:Biomarkers; D004000:Dichloroethylenes; D012997:Solvents; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane; C029297:vinylidene chloride; D013750:Tetrachloroethylene