Spectral karyotyping indicates complex rearrangements in lung adenocarcinoma of nonsmokers.
Adenocarcinoma (AdC) of the lung represents a common histologic subtype of non-small cell lung cancer. While there is a rising incidence of AdC in nonsmoking women, information on the cytogenetic changes involved has been minimal to date. In the present study, spectral karyotyping analysis uncovered the genome-wide chromosomal aberrations in two AdC tumors derived from women who were lifelong nonsmokers. Simple and complex structural rearrangements were indicated. A ploidy status of hypertetraploidy was suggested in both cases, with recurring derivative translocations involving chromosome arms 3q, 8q, 12q, 15q, 22q, and Xq.
Sy
Shirley Ming-Hui
SM
Department of Clinical Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., SAR Hong Kong, China.
Fan
Boli
B
Lee
Tak-Wai
TW
Mok
Tony S-K
TS
Pang
Elizabeth
E
Yim
Anthony
A
Wong
Nathalie
N
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D000782:Aneuploidy; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D032681:Spectral Karyotyping; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured / Q000648:ultrastructure