[S+G2M phase fraction and index of DNA in the aneuploid laryngeal cancer].
Abnormal cellular DNA content, a hallmark of malignancy, is known to be an important prognostic factor in many human solid tumors. The purpose of the following research was to analyze the prognostic value of DNA index in aneuploid squamous cell carcinoma of the larynx and relations between S+G2M phase fraction and clinical as well as histological features of the tumor. Eighty-six patients with squamous cell carcinoma of the larynx treated in years 1997-2002 in the ENT Department of the University Hospital in Wroclaw were subject of our study. Flow cytometric DNA ploidy, S-phase fraction and index DNA measurements were performed on fresh frozen tumor tissues. Results were compared to histological grading and TNM category. We have shown, there is a positive correlation between the histopathological diagnosis and DNA ploidy, between DNA ploidy and S+G2M phase fraction and between the tumor size and S+G2M phase fraction. We noticed a positive correlation between the DNA index of the tumor and presence of the nodal metastases, there was also correlation between the DNA index of the tumor and S+G2M phase fraction.
Katedra i Klinika Otolaryngologii AM we Wrocławiu. zatonski@orl.am.wroc.pl
Tomasz
T
Zatoński
Tomasz
T
Krecicki
Danuta
D
Duś
Maria
M
Zalesska-Krecicka
Michał
M
Jeleń
Monika
M
Kaczmarz
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D016195:G2 Phase; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016196:S Phase
D004273:DNA, Neoplasm