Concise synthesis of isoquinoline via the Ugi and Heck reactions.
[reaction: see text] Two types of isoquinoline scaffolds were successfully constructed in a combinatorial format via the Ugi four-component reaction and the Pd-catalyzed intramolecular Heck reaction, starting from readily available starting materials.
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing, 100871, China.
Zheng
Z
Xiang
Tuoping
T
Luo
Kui
K
Lu
Jiayue
J
Cui
Xiaomeng
X
Shi
Reza
R
Fathi
Jiahua
J
Chen
Zhen
Z
Yang
D020650:Combinatorial Chemistry Techniques; D007546:Isoquinolines / Q000138:chemical synthesis*; D015394:Molecular Structure
D007546:Isoquinolines