The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites.
Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum. Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.
Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd., Mumbai 400 005, India.
K
K
Rajeshwari
Kalpesh
K
Patel
Savithri
S
Nambeesan
Monika
M
Mehta
Alfica
A
Sehgal
Tirtha
T
Chakraborty
Shobhona
S
Sharma
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000097:blood / Q000276:immunology; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology; D000918:Antibody Specificity; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D006801:Humans; D017780:Malaria Vaccines / Q000008:administration & dosage* / Q000276:immunology; D016778:Malaria, Falciparum / Q000517:prevention & control*; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D010750:Phosphoproteins / Q000008:administration & dosage / Q000737:chemistry* / Q000276:immunology; D010963:Plasmodium falciparum / Q000472:pathogenicity*; D015800:Protozoan Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D012269:Ribosomal Proteins / Q000008:administration & dosage / Q000737:chemistry* / Q000276:immunology; D014611:Vaccination
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D017780:Malaria Vaccines; D010455:Peptides; D010750:Phosphoproteins; D015800:Protozoan Proteins; D012269:Ribosomal Proteins; C054675:ribosomal protein P0