[Veno-occlusive liver disease induced by Senecio vulgaris toxicity].
Veno-occlusive liver disease is a well-known clinico-pathological entity. Etiology is varied but the most frequent cause is toxicity. Pirrolizadimic alkaloids, which are found in a large number of vegetables and which are used as therapy, have been identified as the direct origin of this process. We report a 23-year-old woman who presented with abdominal distension. Ascites was recorded semiologically. Laboratory studies and liver biopsy were performed. Histopathology revealed alterations characteristic of veno-occlusive disease and hepatic hemodynamic studies confirmed the diagnosis. Due to chronic constipation, the patient had been taking commercial preparations of herbal infusions which contained Senecio vulgaris. Outcome was favorable and periodic clinical check-ups have been normal to date. The presentation of this case as acute veno-occlusive disease due to pirrolizidinic alkaloids as well as the clinical remission of the effects in the liver are emphasized.
Vilar
J H
JH
Facultad de Medicina, Universidad Nacional del Nordeste, Corrientes, Argentina. jovilar@arnet.com.ar
García
M
M
Cabrera
P
P
D000328:Adult; D001628:Beverages / Q000506:poisoning*; D005260:Female; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced*; D006801:Humans; D012674:Senecio / Q000506:poisoning*