The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis.
A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important for virulence of M. tuberculosis.
Frota
Cristiane C
CC
Division of Mycobacterial Research, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
Papavinasasundaram
K G
KG
Davis
Elaine O
EO
Colston
M Joseph
MJ
D000818:Animals; D051777:AraC Transcription Factor; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001853:Bone Marrow / Q000382:microbiology; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008168:Lung / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*; D014774:Virulence
D051777:AraC Transcription Factor; D001426:Bacterial Proteins; D012097:Repressor Proteins; D014157:Transcription Factors