[Protective effect of bushen ningxin recipe on ovariectomized rabbits with atherosclerosis].
OBJECTIVE
To study the effects of Bushen Ningxin recipe (BNR) on atherosclerosis in ovariectomized rabbits.


METHODS
Twenty-six female New Zealand white rabbits of three months old were randomly divided into four groups, the normal group, the sham operation group, the control group (ovariectomized) and the treated group (ovariectomized and treated with BNR). All rabbits, except the normal group, were fed with high-cholesterol diet starting from two weeks after operation, and to the treated group BNR was given additionally for 3 months. Levels of blood lipid (TC, TG, LDL-C and HDL-C) and NO were measured at the end of the 12th week, and at the same time, histomorphological and pathological examination of aorta under light microscopy and scanning electron microscopy, and the ratio of atherosclerotic area of lesion/endothelium ratio (AL/AE) and thickness of endothelium/medium ratio (TE/TM) were estimated using image analyzer.


RESULTS
No significant difference was found in levels of blood lipid between groups, except those in the normal group. As compared with the control group, in the treated group, level of serum NO was higher, AL/AE and TE/TM were lower and the pathological changes of aorta was milder.


CONCLUSIONS
BNR could inhibit the atherosclerosis formation in ovariectomized rabbits, it showed protection on vascular endothelial cells.
Hao
Qun
Q
Laboratory for Reproductive Immunology, Institute of Obstetrics and Gynecology, Fudan University, Shanghai 200011.
Li
Da-jin
DJ
Zhu
Ying
Y
Yuan
Minmin
M
Wang
Mingyan
M
Meng
Yi
Y
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D009569:Nitric Oxide / Q000097:blood*; D010052:Ovariectomy; D017698:Postmenopause; D011817:Rabbits; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; D014280:Triglycerides; D009569:Nitric Oxide; D002784:Cholesterol