Medium-dependent electron and H atom transfer between 2'-deoxyadenosine and menadione: a magnetic field effect study.
The interaction between 2'-deoxyadenosine and the model antitumor drug menadione has been studied in organic solvent and in micellar medium. The aim of the work is to elucidate the mechanism of this drug-nucleoside interaction and to determine the environmental effects. Laser flash photolysis and magnetic field effect are used to detect the transients and their spin states. The results indicate that H atom transfer and electron transfer are the operative mechanisms depending upon the medium.
Sengupta
Tamal
T
Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064, India.
Dutta Choudhury
Sharmistha
S
Basu
Samita
S
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D003839:Deoxyadenosines / Q000737:chemistry* / Q000378:metabolism; D008280:Magnetics; D010782:Photolysis; D024483:Vitamin K 3 / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
D000970:Antineoplastic Agents; D003839:Deoxyadenosines; D024483:Vitamin K 3; C058118:2'-deoxyadenosine