Effects of an inorganic and two new organic compounds of selenium on morphologic blood elements and antioxidant status in mice.
Two organic compounds, 4-(o-tolilo-)-selenosemicarbazide of p-chlorobenzoic acid and 3-(p-chlorobenzoylamino-)-2-(o-tolylimino-)-4-phenyl-4-selenazoline were compared to the effects of the supplementation with inorganic Na2SeO3. Studies were carried out in four groups consisting of 10 female mice each of SWISS strain. Three of them were supplemented with different selenium formula at the dose of 10(-3) mg Se per g over the period of 10 day. The blood samples were collected to heparinized test tubes; the red blood and white blood count, hematocrit and haemoglobin concentration were studied. The influence of selenium compounds on phagocytosis and NBT test was determined.
Musik
Irena
I
Department of General Chemistry, Medical University of Lublin, Lublin, Poland.
Kozioł-Montewka
Maria
M
Pasternak
Kazimierz
K
Toś-Luty
Sabina
S
Tokarska
Małgorzata
M
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D051379:Mice; D016566:Organoselenium Compounds / Q000494:pharmacology*; D012643:Selenium / Q000378:metabolism*; D018038:Sodium Selenite / Q000494:pharmacology*; D014018:Tissue Distribution
D000975:Antioxidants; D016566:Organoselenium Compounds; D012643:Selenium; D018038:Sodium Selenite