The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS.
Timms
Andrew E
AE
Institute of Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford, United Kingdom.
Crane
Alison M
AM
Sims
Anne-Marie
AM
Cordell
Heather J
HJ
Bradbury
Linda A
LA
Abbott
Aaron
A
Coyne
Mark R E
MR
Beynon
Owen
O
Herzberg
Ibi
I
Duff
Gordon W
GW
Calin
Andrei
A
Cardon
Lon R
LR
Wordsworth
B Paul
BP
Brown
Matthew A
MA
D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D004252:DNA Mutational Analysis; D017931:DNA Primers; D004587:Electrophoresis, Agar Gel; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015796:HLA-B27 Antigen / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D007375:Interleukin-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D006113:United Kingdom
D017931:DNA Primers; D015796:HLA-B27 Antigen; D007375:Interleukin-1