Neuronal network models of ADHD -- lateralization with respect to interhemispheric connectivity reconsidered.
BACKGROUND
Recent research on structural and functional anatomy related to ADHD has concentrated on fronto-striatocerebellar circuits. These findings and resultant neurobiological models of ADHD may explain some of the disturbances. On the other hand, there is some evidence that the restricted look at anterior-posterior anomalies might neglect the important additional information of lateralization problems related to hemispheric connectivity.


OBJECTIVE
Hence, the role of lateralization in the pathophysiology of ADHD should be reconsidered.


METHODS
After a short review of imaging studies in ADHD the special role of the corpus callosum (including the influence of its anomalies on general brain development, lateralization and functioning) is outlined and the first case of total agenesis of corpus callosum in a child with ADHD is presented and discussed within this context.


CONCLUSIONS
In view of the remaining inconsistencies concerning structural and functional brain anomalies in ADHD, attention should be paid not only to anterior- posterior but also to left-right aspects of functional and structural brain anomalies. This should include disturbances probably related to anomalies of the corpus callosum, especially in regard to co-existing problems like dyslexia and developmental coordination disorder.
University of Goettingen, Child and Adolescent Psychiatry, von-Siebold-Strasse 5, 37075, Goettingen, Germany. vroessn@gwdg.de
Veit
V
Roessner
Tobias
T
Banaschewski
Henrik
H
Uebel
Andreas
A
Becker
Aribert
A
Rothenberger
D061085:Agenesis of Corpus Callosum; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002648:Child; D004569:Electroencephalography; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D009415:Nerve Net / Q000503:physiopathology*; D012720:Severity of Illness Index
D000697:Central Nervous System Stimulants; D008774:Methylphenidate