Emergence of CTX-M beta-lactamase-producing Enterobacteriaceae in Portugal: report of an Escherichia coli isolate harbouring blaCTX-M-14.
CTX-M beta-lactamases have been reported worldwide since their first description in the early 1990s, and are now endemic in some countries. This report describes an isolate of Escherichia coli producing CTX-M-14 that was recovered from the faecal sample of a healthy subject in Portugal without recent hospital or antibiotic exposure. The presence of ISEcp1, 42 nucleotides upstream of bla(CTX-M-14), and its association with a 100-kb conjugative plasmid, might result in wider dissemination of this enzyme in community and hospital environments in Portugal.
Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, 4050-047 Porto, Portugal.
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D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D011174:Portugal; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; C456080:beta-lactamase CTX-M-14; D001618:beta-Lactamases