Monopolar versus bipolar high frequency stimulation in the rat subthalamic nucleus: differences in histological damage.
The aim of the present study was to determine the effects of monopolar and bipolar high frequency stimulation (HFS) on histological damage and current flow using a commonly applied stimulus amplitude (300 microA). Bipolar HFS resulted in a large amount of histological damage whereas with monopolar HFS no damage was observed except for the electrode trajectory. Oscilloscopic readings confirmed that this was due to the application of twice as much current to the target with bipolar HFS. Our results demonstrate that there are differences in tissue damage dependent of polarity. In order to create a better comparison to the clinical condition, we suggest that the present rodent models for studying the effect of chronic HFS require further adjustment. This can be achieved by decreasing the present current densities to a level comparable to the human situation.
Temel
Yasin
Y
Department of Neuroscience, European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands. yasintemel@yahoo.com
Visser-Vandewalle
Veerle
V
van der Wolf
Martin
M
Spincemaille
Geert H
GH
Desbonnet
Lieve
L
Hoogland
Govert
G
Steinbusch
Harry W M
HW
D000818:Animals; D001930:Brain Injuries / Q000209:etiology* / Q000473:pathology; D004558:Electric Stimulation / Q000009:adverse effects*; D004566:Electrodes; D007839:Functional Laterality / Q000528:radiation effects; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D020531:Subthalamic Nucleus / Q000473:pathology / Q000528:radiation effects*