Cyclosporine A-induced ocular opsoclonus and reversible leukoencephalopathy after orthotopic liver transplantation: brief report.
Ocular opsoclonus is a rare neurologic condition that occurs in patients with brain stem encephalitis, neoplasm of the mesencephalon, paraneoplastic syndrome or intoxication. Neurotoxicity is a well-known complication of cyclosporine-A (CSA) therapy. We report a case of a 17-year-old patient, a Caucasian female, who underwent an orthotopic liver transplantation (OLT) for immunologic cirrhosis and chronic cellular rejection respectively. The ocular symptoms occurred 8 days after the OLT. She also developed reversible posterior leukoencephalopathy. The serum level of CSA was 412 ng/mL. The ocular symptoms improved 21 days after the reduction of the CSA level.
Neurologic Clinic, Department of Neurology, São Paulo University School of Medicine, São Paulo, Brazil. div.neuro@hcnet.usp.br
Paulo Eurípedes
PE
Marchiori
Sergio
S
Mies
Milberto
M
Scaff
D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced*; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000601:surgery*; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods; D015835:Ocular Motility Disorders / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D016572:Cyclosporine