[Effect of thyroxin and thymalin on proliferation and apoptosis of thymocytes in rats after thyroidectomy].
It is found that 3 months after removal of thyroid gland in rats, a suppression of thymic endocrine function, loss of weight and cellularity occurs. These changes are mainly caused by a weakening of index of proliferative activity. In animals that postoperatively received substitutive thyroxin hormonotherapy and courses of thymulin these disorders don't occur or they are not expressed significantly.
Hrinevych
Iu Ia
IuIa
Bendiuh
H D
HD
Khranovs'ka
N M
NM
Bilokin'
Iu M
IuM
Ostapenko
O M
OM
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D020249:Hormone Replacement Therapy; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology; D013951:Thymus Hormones / Q000494:pharmacology* / Q000627:therapeutic use; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology* / Q000627:therapeutic use
D013951:Thymus Hormones; C032805:thymalin; D013974:Thyroxine