Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells.
A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Shunji
S
Aoki
Dexin
D
Kong
Kouhei
K
Matsui
Rachmaniar
R
Rachmat
Motomasa
M
Kobayashi
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D004900:Erythroblasts / Q000737:chemistry / Q000166:cytology / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D020014:K562 Cells; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006454:Hemoglobins; D011809:Quinones; D012717:Sesquiterpenes