Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto beta-boswellic acid (KBA), acetyl beta-boswellic acid and beta-boswellic acid has been evaluated for antianaphylactic and mast cell stabilizing activity using passive paw anaphylaxis and compound 48/80 induced degranulation of mast cell methods. The extract inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner (20, 40 and 80 mg/kg, po). However, the standard dexamethasone (0.27 mg/kg, po) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependant manner (20, 40 and 80 mg/kg, po) was observed thus showing mast cell stabilizing activity. The standard disodium cromoglycate (50 mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA. The results suggest promising antianaphylactic and mast cell stabilizing activity of the extract.
C. U. Shah College of Pharmacy, Sir Vithaldas Vidya Vihar, SNDT Women's University, Juhu, Santacruz (W), Mumbai 400 049, India.
Pratibha
P
Pungle
M
M
Banavalikar
A
A
Suthar
M
M
Biyani
S
S
Mengi
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000707:Anaphylaxis / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D029743:Boswellia / Q000737:chemistry*; D015550:Cell Degranulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D014315:Triterpenes; C054625:boswellic acid