Bisacridines with aromatic linking chains. Synthesis, DNA interaction, and antitumor activity.
Synthesis of a series of bisacridine derivatives containing rigid aromatic linking chains is described. Their DNA interaction and in vitro cytotoxicity against HT-29 human carcinoma cells are reported.
Departamento de Química Orgánica, Universidad de Alcalá, Alcalá de Henares, 28871 Madrid, Spain. antonio.lorente@uah.es
Antonio
A
Lorente
Yolanda G
YG
Vázquez
María-José
MJ
Fernández
Abel
A
Ferrández
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity*; D045744:Cell Line, Tumor; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity*
D000166:Acridines; D000970:Antineoplastic Agents; D007364:Intercalating Agents; C484811:bis-acridine; D004247:DNA