Neuromuscular blocking agents block carotid body neuronal nicotinic acetylcholine receptors.
Neuromuscular blocking agents predominantly block muscle type nicotinic acetylcholine receptors as opposed to the neuronal type. However, there is growing evidence that neuromuscular blocking agents have affinity to some neuronal nicotinic acetylcholine receptors. The carotid body chemoreceptor as the essential oxygen-sensing cell, relies on cholinergic signalling. Atracurium and vecuronium impair carotid body chemoreceptor activity during hypoxia. Here, we characterize atracurium and vecuronium as antagonists at nicotinic receptors of the carotid body chemoreceptor. Isolated rabbit carotid body preparations with carotid sinus nerve were used, and chemoreceptor activities were recorded. There was a concentration-dependent reduction in the chemoreceptor responses to nicotine, with an IC(50) to 50 microg nicotine of 3.64 and 1.64 microM and to 500 microg nicotine of 27.00 microM and 7.29 microM for atracurium and vecuronium, respectively. It is concluded that atracurium and vecuronium depress nicotine-induced chemoreceptor responses of the carotid body in a dose-dependent fashion.
Department of Anesthesiology and Intensive Care Medicine, Karolinska Hospital and Institute, SE-171 76 Stockholm, Sweden. Malin.jonsson@ks.se
Malin
M
Jonsson
Nicholas
N
Wyon
Sten G E
SG
Lindahl
Bertil B
BB
Fredholm
Lars I
LI
Eriksson
D000818:Animals; D002344:Carotid Body / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology; D018733:Nicotinic Antagonists / Q000494:pharmacology; D011817:Rabbits; D011978:Receptors, Nicotinic / Q000502:physiology*
D009466:Neuromuscular Blocking Agents; D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; D009538:Nicotine