Polychlorinated biphenyls contamination in women with breast cancer.
BACKGROUND
Polychlorinated biphenyls (PCBs) are widespread highly resistant pollutants in the environment with potential adverse health effects on humans. The aim of the study was to compare PCBs contamination in women suffering from breast cancer with presumably healthy women.


METHODS
A gas-chromatography/mass-spectrometry method was used to identify and quantify seven PCBs congeners (IUPAC 28, 52, 101, 118, 138, 153,180) in blood from 60 cases of breast cancer and 60 age-matched healthy controls.


RESULTS
Cases and controls had similar risk profiles, except for menopausal status (respectively 82% vs. 65%, p=0.014). PCBs were detectable in 69.1% of the samples. Total blood level of PCBs was significantly different (p=0.012) in cases (7.08+/-7.51 ppb) and controls (5.10+/-5.15 ppb). The relationship between PCBs concentrations in serum and risk factor was mainly due to serum levels of PCB153, which were significantly higher in breast cancer women than in disease-free subjects (1.63+/-1.26 ppb vs. 0.63+/-0.78 ppb, p<0.0001), even after accounting for other potential risk factors.


CONCLUSIONS
These results suggest that environmental exposure to PCBs may contribute to multifactorial pathogenesis of breast cancer.
Charlier
Corinne J
CJ
Clinical Toxicology Laboratory, Liege University Hospital, Tour II+5, CHU Sart-Tilman, B 4000 Liège, Belgium. C.Charlier@chu.ulg.ac.be
Albert
Adelin I
AI
Zhang
Liying
L
Dubois
Nathalie G
NG
Plomteux
Guy J
GJ
D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism*; D004785:Environmental Pollutants / Q000032:analysis / Q000378:metabolism*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D016015:Logistic Models; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000378:metabolism*; D012307:Risk Factors
D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls