gp120 sequences from HIV type 1 subtype C early seroconverters in India.
A limited number of full-length gp120 sequences are currently available for subtype C HIV-1 from India. Sequence data from HIV-1 subtype C in early seroconverter stage virus are also very limited. With the objective of identifying the sequence variation in early seroconverters, we compared Indian subtype C gp120 sequences obtained from six early seroconverters presented in this study with non-Indian subtype C sequences from other parts of the world obtained from the Los Alamos database and subtype C potential vaccine candidate sequences. All these samples were collected within a few weeks of seroconversion and hence they represent gp120 sequences of currently circulating viral strains in India. The phylogenetic tree indicated that the Indian sequences compared here clustered together within the C clade. The seroconverter sequences presented in the study would surely help in identifying the immunogenic epitopes and could be utilized further for developing effective prophylactic strategies against HIV-1 subtype C for India.
Department of Molecular Virology, National AIDS Research Institute, Pune, India.
Agnihotri
A
Kalpana
Tripathy
T
Srikanth
Jere
J
Abhay
Jadhav
J
Sushama
Kurle
K
Swarali
Paranjape
P
Ramesh
D000595:Amino Acid Sequence; D014644:Genetic Variation; D016679:Genome, Viral; D015699:HIV Envelope Protein gp120 / Q000145:classification / Q000235:genetics*; D006679:HIV Seropositivity / Q000453:epidemiology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D007194:India; D008969:Molecular Sequence Data; D010802:Phylogeny
D015699:HIV Envelope Protein gp120