Effects of Antiadhesion preparation on free fibrinogen and fibrin degrading products in abdominal exudates of rabbits postoperatively.
OBJECTIVE
To observe effects of ACOL on fibrinogen (FIB), fibrin degrading products (FDP) and changes of FIB and FDP concentration in rabbits with intro-abdominal exudates during 7 d after major abdominal surgery.


METHODS
Sixty New Zealand rabbits were randomly divided into 4 groups: ACOL group, the control group, DCT group and the normal group. After being modeled, except the normal group, the other 3 groups were treated with different ways for a week; the intro-abdominal exudates of rabbits in the 4 groups were drawn for FIB and FDP measurement once daily during 7 d after major abdominal surgery.


RESULTS
FIB and FDP in the intro-abdominal exudates altered in a regular way and ACOL could change the concentration of FIB and FDP in the intra-abdominal exudates after major abdominal surgery.


CONCLUSIONS
ACOL can prevent intestinal adhesion by reducing the concentration of FIB and raising that of FDP in the intro-abdominal exudates after major abdominal surgery.
Department of Hepatobiliary Surgery, Xi'an Jiaotong University First Hospital, Xi'an 710061, Shaanxi Providence, China. stage9909@sina.com
You-Li
YL
Wang
Cheng-En
CE
Pan
Ping-Lin
PL
Yang
Yuan
Y
Tian
Shu-Wen
SW
Pei
Ming
M
Dong
D000005:Abdomen / Q000601:surgery; D000818:Animals; D001202:Ascitic Fluid / Q000187:drug effects / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005122:Exudates and Transudates / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control; D011817:Rabbits; D000267:Tissue Adhesions / Q000188:drug therapy / Q000517:prevention & control*
D004365:Drugs, Chinese Herbal; D005337:Fibrin; D005340:Fibrinogen