In vitro leishmanicidal activity of some scarce natural products.
Leishmanicidal activity of 46 natural products including several fern and Betula constituents was examined. Several pterosin and atisene compounds from ferns had high activity. Among the triterpenoids the carboxyl group was found to be important for activity. In the diarylheptanoids, the linear-type and the diphenylether-type showed significant activity, and it was found that the carbonyl group at C-11 is necessary for the activity of biphenyl-types.
Takahashi
Marii
M
Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Tsukuba, Japan.
Fuchino
Hiroyuki
H
Sekita
Setsuko
S
Satake
Motoyoshi
M
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029662:Betula; D029624:Ferns; D020128:Inhibitory Concentration 50; D018320:Leishmania major / Q000187:drug effects*; D016773:Leishmaniasis, Cutaneous / Q000517:prevention & control; D008517:Phytotherapy; D010946:Plants, Medicinal
D000981:Antiprotozoal Agents