Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis.
In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.
Manca
Claudia
C
Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, International Center for Public Health, 225 Warren St., Newark, NJ 07103-3535, USA.
Reed
Michael B
MB
Freeman
Sherry
S
Mathema
Barun
B
Kreiswirth
Barry
B
Barry
Clifton E
CE
Kaplan
Gilla
G
D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D009000:Monocytes / Q000166:cytology* / Q000276:immunology / Q000382:microbiology*; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity; D013045:Species Specificity; D018417:Th1 Cells; D018418:Th2 Cells; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000382:microbiology; D014774:Virulence
D016207:Cytokines; D018793:Interleukin-13; D018664:Interleukin-12; D015847:Interleukin-4