Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion.
We investigated if the antiviral drug tenofovir has immunomodulatory effects in macaques, similar to those described in murine models. While in vivo experiments were complicated by high individual and temporal variability of immune parameters, tenofovir primed macaque peripheral blood mononuclear cells in vitro for enhanced IL-12 secretion following exposure to bacterial antigens.
California National Primate Research Center, University of California, Davis, CA 95616, USA. kkvanrompay@ucdavis.edu
Koen K A
KK
Van Rompay
Marta L
ML
Marthas
Norbert
N
Bischofberger
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D002478:Cells, Cultured; D007155:Immunologic Factors / Q000494:pharmacology*; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D008253:Macaca mulatta; D063065:Organophosphonates / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000276:immunology; D000068698:Tenofovir
D000942:Antigens, Bacterial; D007155:Immunologic Factors; D008070:Lipopolysaccharides; D063065:Organophosphonates; D018664:Interleukin-12; D000068698:Tenofovir; D000225:Adenine