Dynamics of gene regulatory networks with cell division cycle.
This paper focuses on modeling and analyzing the nonlinear dynamics of gene regulatory networks with the consideration of a cell division cycle with duplication process of DNA, in particular for switches and oscillators of synthetic networks. We derive two models that may correspond to the eukaryotic and prokaryotic cells, respectively. A biologically plausible three-gene model ( lac, tetR, and cI ) and a repressilator as switch and oscillator examples are used to illustrate our theoretical results. We show that the cell cycle may play a significant role in gene regulation due to the nonlinear dynamics of a gene regulatory network although gene expressions are usually tightly controlled by transcriptional factors.
Chen
Luonan
L
Department of Electrical Engineering and Electronics, Osaka Sangyo University, 3-1-1 Nakagaito, Daito, Osaka 574-8530, Japan.
Wang
Ruiqi
R
Kobayashi
Tetsuya J
TJ
Aihara
Kazuyuki
K
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D004247:DNA / Q000378:metabolism*; D004261:DNA Replication / Q000502:physiology*; D004926:Escherichia coli / Q000166:cytology / Q000502:physiology; D029968:Escherichia coli Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D005812:Genes, Switch / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008957:Models, Genetic; D017711:Nonlinear Dynamics; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*
D029968:Escherichia coli Proteins; D014157:Transcription Factors; D004247:DNA