Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population.
The association between Glutathione S-Transferase M1 gene (GSTM1) polymorphism and schizophrenia was examined. One hundred and eleven in-patients with schizophrenia and 130 healthy controls were enrolled in this study. Genotyping was performed using a polymerase chain reaction-based method. The GSTM1 null genotype was significantly more frequent in the schizophrenia patients than in the controls (P=0.014, odds ratio=1.93, 95% confidence interval=1.115-3.351). On the other hand, the GSTM1 genotype variants were not associated with tardive dyskinesia or total abnormal involuntary movement scale scores. This study suggests that, at least in the Korean population, the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to tardive dyskinesia.
Department of Psychiatry, Kangnam St Mary's Hospital, The Catholic University of Korea College of Medicine, Banpo-Dong, Seocho-Gu, Seoul, Korea.
Chi-Un
CU
Pae
Hye-Sook
HS
Yu
Jung-Jin
JJ
Kim
Won
W
Kim
Chang-Uk
CU
Lee
Soo-Jung
SJ
Lee
Tae-Youn
TY
Jun
Chul
C
Lee
In-Ho
IH
Paik
Alessandro
A
Serretti
D000328:Adult; D017109:Akathisia, Drug-Induced / Q000235:genetics; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*
D005982:Glutathione Transferase