Decreased MMP-9 production in primary progressive multiple sclerosis patients.
BACKGROUND
An increase in MMP-9 levels has been found in relapsing-remitting (RR) multiple sclerosis (MS) showing correlation with magnetic resonance (MR) parameters mainly during relapses. However, data regarding primary progressive (PP) MS is scarce.


OBJECTIVE
To determine both the pro and active forms of MMP-9 in PPMS and transitional progressive (TP) MS, RRMS and healthy controls (HC), and to assess the relationship between MMP-9 levels and clinical and radiological variables in PP/TPMS.


METHODS
73 patients with PP/TPMS, 50 RRMS and 43 HC were studied. Levels of pro and active forms of MMP-9 in serum were measured with ELISA. EDSS and MSFC scores were recorded and T2- and T1-weighted MR scans were obtained at the time of blood sampling and one and two years later for PP/TP MS cases.


RESULTS
MMP-9 levels were 202.27 ng/ml for PP/TPMS, 242.20 ng/ml for RRMS and 274.49 ng/ml for HC. MMP-9 levels were significantly lower in PP/TPMS compared to RRMS (P= 0.026) and HC (P= 0.001). No significant correlations were found between MMP-9 levels and clinical scores or radiological parameters.


CONCLUSIONS
These results point to different regulatory mechanisms of MMP-9 production and/or activity between PP/TPMS and RRMS.
Unitat de Neuroimmunologia Clínica, Hospital Vail d'Hebron, Barcelona, Espanya. jsastre@hg.vhebron.es
J
J
Sastre-Garriga
M
M
Comabella
L
L
Brieva
A
A
Rovira
M
M
Tintoré
X
X
Montalban
D000328:Adult; D016022:Case-Control Studies; D004185:Disability Evaluation; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis* / Q000097:blood; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index
D020780:Matrix Metalloproteinase 9