Laser stereolithography and supercritical fluid processing for custom-designed implant fabrication.
This paper describes the laser photopolymerization of a liquid mixture of polyfunctional acrylic monomers, photoinitiator and hydroxyapatite (HA). Pure polymeric and composite materials of specific shape and structure were fabricated by laser stereolithography based on images derived from three-dimensional (3D) computer modeling. The polymeric objects then were treated with supercritical carbon dioxide to remove potentially toxic residues (monomers, low molecular weight oligomers, etc.) and to provide interconnective microporosity. Finally, samples were implanted into white rats (diastolic epiphysis of femoral bone) to study living tissue response and processes of osteointegration and osteoinduction. It was shown that incorporation of HA into the composite implant structure encouraged periosteal as well as endosteal osteogenesis and improved their osteointegrative characteristics in particular. Supercritical carbon dioxide treatment significantly enhanced the biocompatibility of the materials, increasing the area of direct contact of the implant surface with regenerated bone tissue.
Institute on Laser and Information Technologies, Russian Academy of Sciences, Pionerskaya 2, Troitsk/Shatura, Moscow Region 142092, Russia. popov@laser.ru
V K
VK
Popov
A V
AV
Evseev
A L
AL
Ivanov
V V
VV
Roginski
A I
AI
Volozhin
S M
SM
Howdle
D000818:Animals; D003198:Computer Simulation; D017886:Durapatite; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D007834:Lasers; D008334:Mandible / Q000601:surgery*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D019736:Prostheses and Implants; D051381:Rats; D019651:Plastic Surgery Procedures; D014783:Viscosity
D007202:Indicators and Reagents; D017886:Durapatite