Pathogen recognition or homeostasis? APC receptor functions in innate immunity.
Myeloid cells (macrophages, neutrophils, dendritic cells) express a repertoire of plasma membrane receptors able to recognize all classes of macromolecules. The concept of pattern recognition has emphasized microbial ligands and host defence. However, these receptors play a broader role in tissue homeostasis within multicellular hosts, clearing the extracellular environment of potential undesirable ligands arising endogenously as well as from without. This article will evaluate one of the paradigms that underlie innate immunity.
Sir William Dunn School of Pathology, South Parks Road, Oxford OXI 3RE, UK. christine.holt@path.ox.ac.uk
Siamon
S
Gordon
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology
D011971:Receptors, Immunologic