Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis.
In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.
Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, International Center for Public Health, 225 Warren St., Newark, NJ 07103-3535, USA.
Claudia
C
Manca
Michael B
MB
Reed
Sherry
S
Freeman
Barun
B
Mathema
Barry
B
Kreiswirth
Clifton E
CE
Barry
Gilla
G
Kaplan
D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D009000:Monocytes / Q000166:cytology* / Q000276:immunology / Q000382:microbiology*; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity; D013045:Species Specificity; D018417:Th1 Cells; D018418:Th2 Cells; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000382:microbiology; D014774:Virulence
D016207:Cytokines; D018793:Interleukin-13; D018664:Interleukin-12; D015847:Interleukin-4