Prognostic value of P53, MDM-2, and MUC-1 for patients with inflammatory breast carcinoma.
BACKGROUND
Inflammatory breast carcinoma (IBC) is a rare and aggressive malignancy. Therapy for patients with IBC is multidisciplinary, and response to preoperative chemotherapy is considered an important predictor of outcome. Although only a limited number of molecular markers have been investigated in this setting, none has exhibited prognostic value for patients with IBC.


METHODS
Immunohistochemical assays for P53, MDM-2, and MUC-1 were performed retrospectively to evaluate potential correlations between these markers and pathologic response, time to progression (TTP), and overall survival (OS) in 19 patients with IBC.


RESULTS
After a median follow-up period of 46 months, patients with tumors that overexpressed P53 and did not express MUC-1 had a significantly shorter median TTP and median OS compared with other patients.


CONCLUSIONS
Expression of P53 and MUC-1 may be predictive of treatment efficacy and outcome for patients with IBC. Furthermore, these two markers may represent novel therapeutic targets in such patients.
Resetkova
Erika
E
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA.
Gonzalez-Angulo
Ana M
AM
Sneige
Nour
N
Mcdonnell
Timothy J
TJ
Buzdar
Aman U
AU
Kau
Shu Wan
SW
Yamamura
Yuko
Y
Reuben
James M
JM
Hortobagyi
Gabriel N
GN
Cristofanilli
Massimo
M
D000328:Adult; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051736:Proto-Oncogene Proteins c-mdm2; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D016335:Zinc Fingers
D014408:Biomarkers, Tumor; D018396:Mucin-1; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2