Inhibitory effects of 7-hydroxy-3-methoxy-cadalene on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.
The present study was undertaken to estimate the effect of 7-hydroxy-3-methoxycadalene (cadalene) extracted from Zelkova serrata on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. Twenty mice received orally NNK at a dose of 65 microg/ml water for 7 weeks following by free feeding of a commercial diet not containing cadalene for 2 weeks. Control group was maintained without NNK and cadalene administration and/or treatment groups with NNK and cadalene (6.25, 25, 100 mg/kg feed) feeding for 25 weeks. Lung tumors were induced by NNK at incidence ranging from 10 to 45%. Cadalene treatment (100 mg/kg feed) group significantly reduced the incidence of adenomas from 45 to 10% (P < 0.05), and other cadalene treatment group decreased cancer incidences in a concentration dependent manner. The results of our study strongly indicate that cadalene is capable of inhibiting development of NNK-induced lung tumorigenesis in A/J mice.
Department of Environmental Health, Graduate School of Public Health, Seoul National University, 28 Yeungeon-Dong, Chongno-Gu, 110-799, South Korea.
Jung Hyon
JH
Kim
Hu Jang
HJ
Lee
Gon Sup
GS
Kim
Don Ha
DH
Choi
Sung Suk
SS
Lee
Jong Koo
JK
Kang
Chanhee
C
Chae
Nam Won
NW
Paik
Myung-Haing
MH
Cho
D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D051379:Mice; D009374:Neoplasms, Experimental; D009602:Nitrosamines / Q000494:pharmacology*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000494:pharmacology*; D034401:Ulmaceae / Q000737:chemistry
C492720:7-hydroxy-3-methoxy-cadalene; D002273:Carcinogens; D009602:Nitrosamines; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone