Motor-vehicle collision-related death due to delayed-onset subarachnoid hemorrhage associated with anticoagulant therapy.
Delayed deaths following injury are not rare. Various mechanisms may be responsible for such deaths, including pulmonary thromboembolism, fat embolism, infection, systemic inflammatory response syndrome, and delayed hemorrhage. In the present case, we describe a death due to delayed subarachnoid hemorrhage following a motor vehicle collision, wherein the hemorrhage occurred ten days after the incident, while the patient remained hospitalized for skeletal trauma. At no time prior to the hemorrhage did the victim show any symptoms of brain injury. Autopsy revealed basilar subarachnoid hemorrhage arising from a cerebral cortical contusion. There was no evidence of aneurysm or arteriovenous malformation. A significant underlying contributing factor in the delayed hemorrhage was the victim's chronic anticoagulant therapy, which was required because of a mechanical heart valve.
Lopez
Ana E
AE
Southwestern Institute of Forensic Sciences, Dallas, TX, USA.
Barnard
Jeffrey J
JJ
White
Charles L
CL
Oeberst
Jaime L
JL
Prahlow
Joseph A
JA
D000063:Accidents, Traffic; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001021:Aortic Valve; D001930:Brain Injuries / Q000150:complications* / Q000209:etiology* / Q000473:pathology; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D013345:Subarachnoid Hemorrhage / Q000209:etiology* / Q000473:pathology; D013923:Thromboembolism / Q000517:prevention & control; D013997:Time Factors
D000925:Anticoagulants