Reference regions of two or more dimensions.
Despite being proposed over 30 years ago, the multivariate reference region (MRR) remains an interpretive tool with uncertain value in clinical practice. This paper reviews the mathematical theory of the MRR, presents topics in the clinical application of MRRs, and examines the advantages and disadvantages of MRRs. Finally, some thoughts are offered regarding future directions for work in this field.
Department of Pathology, University of Virginia Health System, Charlottesville, 22901, USA. jboyd@virginia.edu
James C
JC
Boyd
D000704:Analysis of Variance; D006801:Humans; D008962:Models, Theoretical; D016011:Normal Distribution; D012016:Reference Values