Expression of epidermal growth factor-receptor related protein (ERRP) in human colorectal carcinogenesis.
We hypothesize that ERRP (EGFR-related protein), a recently identified negative regulator of EGFR may modulate EGFR function in colorectal carcinogenesis. The expression of ERRP and EGFR in normal and neoplastic colorectal tissue was examined. ERRP was highly expressed in normal colonic mucosa and benign colorectal adenomas, but lower in colorectal cancer. Mean scores for ERRP expression decreased significantly across well differentiated, moderately well differentiated and poorly differentiated (P = 0.002) tumors, respectively. ERRP expression became more attenuated in polyps with increasing grades of dysplasia. In contrast, expression of EGFR was inversely related to ERRP in representative samples of normal and neoplastic tissues.
Jaszewski
Richard
R
Veterans Affairs Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Research Service 151, 4646 John R, Detroit, MI 48201, USA.
Levi
Edi
E
Sochacki
Paula
P
Frank
John
J
Kucuk
Omer
O
Axelrod
Bradley N
BN
Majumdar
Adhip P N
AP
D000236:Adenoma / Q000235:genetics; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D003106:Colon / Q000502:physiology; D003111:Colonic Polyps / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D015513:Oncogene Proteins
D006023:Glycoproteins; D015513:Oncogene Proteins; D004815:Epidermal Growth Factor; C512478:EGFR protein, human; D066246:ErbB Receptors