Emergence of macrolide-resistant Streptococcus pyogenes strains in French children.
We studied the antimicrobial susceptibility of 322 Streptococcus pyogenes throat isolates from French children and their serotype and genomic diversity. A total of 22.4% were erythromycin resistant, and 69.4, 4.2, and 26.4% of these isolates harbored ermB, ermA, and mefA, respectively. Increasing resistance in France is mainly associated with a few emm type 28 clones.
Université Denis Diderot-Paris 7, Service de Microbiologie, Hôpital Robert Debré, 48 Bd Sérurier, 75019 Paris, France. edouard.bingen@rdb.ap-hop-paris.fr
Edouard
E
Bingen
Philippe
P
Bidet
Liliana
L
Mihaila-Amrouche
Catherine
C
Doit
Samuel
S
Forcet
Naïma
N
Brahimi
Anne
A
Bouvet
Robert
R
Cohen
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005602:France / Q000453:epidemiology; D016680:Genome, Bacterial; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008565:Membrane Proteins / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010612:Pharyngitis / Q000382:microbiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012703:Serotyping; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D018942:Macrolides; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D008780:Methyltransferases; C431709:ErmA protein, Bacteria