Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare.
We report two cases of adverse cutaneous reactions following hepatitis B vaccination. The first case occurred 3 weeks after the first dose of hepatitis B vaccine in a 16-year-old white girl with the onset of lichen planus lesions on her thighs and abdomen. After the second dose a disseminated lichen planus developed within 2 weeks. The second case concerns to the development of papular and patch granuloma annulare in a 58-year-old white woman 2 months after the second dose of hepatitis B vaccine. To the best of our knowledge, only a few paediatric and adult cases of lichen planus as a complication of hepatitis B vaccination have been reported in medical literature so far. This is the second case of granuloma annulare following hepatitis B vaccine. Our report, similar to earlier papers, appears to support the onset of lichen planus and granuloma annulare as a possible rare complication of hepatitis B immunization.
Dermatology Unit, Allergy Unit, Estadual de Sao Paulo, Brazil. prcriado@uol.com.br
P R
PR
Criado
R
R
de Oliveira Ramos
C
C
Vasconcellos
R F
RF
Jardim Criado
N Y S
NY
Valente
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003898:Desonide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D016460:Granuloma Annulare / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007866:Leg; D008010:Lichen Planus / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged
D000893:Anti-Inflammatory Agents; D017325:Hepatitis B Vaccines; D008795:Metronidazole; D003898:Desonide