Signal transducer and activator of transcription 5 (STAT5).
Signal transducer and activator of transcription 5 (STAT5) activity is induced by a plethora of cytokines and growth factors resulting in transcriptional activation of specific target genes. STAT5 plays an important role in a variety of cellular processes, including proliferation, differentiation, and apoptosis. Aberrant regulation of STAT5 has been observed in solid tumors as well as in patients with either chronic or acute myeloid leukemia. Kinase inhibitors are currently being developed to negatively regulate STAT5 activity for clinical purposes.
Buitenhuis
Miranda
M
Department of Pulmonary Diseases, G03.550, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. m.buitenhuis@hli.azu.nl
Coffer
Paul J
PJ
Koenderman
Leo
L
D016207:Cytokines / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008894:Milk Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D050799:STAT5 Transcription Factor; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism*; D025521:Tumor Suppressor Proteins
D016207:Cytokines; D004268:DNA-Binding Proteins; D006133:Growth Substances; D008894:Milk Proteins; D050799:STAT5 Transcription Factor; C494092:STAT5A protein, human; D015534:Trans-Activators; D025521:Tumor Suppressor Proteins