[Effect of adaptation to high altitude on the state of electric cardiac stability and lipid peroxidation during catecholamine cardionecrosis in rats].
The change of electric cardiac stability parameters and LP in catecholamine cardio necrosis in rats simulated by prolonged injection of increasing doses of noradrenaline was studied in this work. It was established that noradrenaline injection in low-altitude (760 m) and high-altitude (3200 m) is accompanied by hypertrophy, microcirculation disturbances, ischemia and cardiomyocytes necrosis, ECS decrease, LP activation and decrease of enzymatic activity of antioxidant defense. ECS of animals adapted to high-altitude decreased less and their LP processes were more active with preservation of enzymatic activity of antioxidant defense.
Zakharov
G A
GA
Ubasheva
Ch A
ChA
Mishchenko
I K
IK
Gorokhova
G I
GI
D000222:Adaptation, Physiological; D000531:Altitude; D000818:Animals; D004195:Disease Models, Animal; D004594:Electrophysiology; D006331:Heart Diseases / Q000473:pathology / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D009638:Norepinephrine / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D009638:Norepinephrine