On the preparation of ortho-trifluoromethyl phenyl triflate.
In contrast to an earlier report advocating a copper-mediated trifluoromethylation of ortho-iodophenyl triflate, ortho-trifluoromethyl phenyl triflate may be prepared simply by reacting the corresponding phenol with triflic anhydride in the presence of a nucleophilic catalyst and stoichiometric base.
Gill
Duncan
D
AstraZeneca, Loughborough, Leicestershire, UK.
Hester
Alison J
AJ
Lloyd-Jones
Guy C
GC
D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D006845:Hydrocarbons, Fluorinated; D010636:Phenols; C501566:ortho-trifluoromethyl phenyl triflate