The short-/intermediate-term changes in novel vascular inflammatory markers after angioplasty plus stenting in patients with symptomatic advanced systemic arterial diseases.
Studies on cell adhesion molecules and high-sensitivity C-reactive protein (hs-CRP) in systemic arterial diseases are limited in numbers and some results not consistent. It also remains undefined whether, for how long and to what extent these markers are perturbed after angioplasty. Patients with systemic arterial diseases admitted for percutaneous transluminal angioplasty (PTA) by standard procedures and techniques were prospectively studied. Fasting morning blood samples were collected to determine general biochemistry and relevant molecules by commercially available methods at baseline, 2 weeks and 3 months post-PTA/stenting. A group of equally numbered sex- and age-matched asymptomatic subjects without illness were selected as control. A total of 33 patients (28 M/5 F, aged 72 +/- 2 years) were recruited. Patients with systemic arterial disease had significantly higher baseline serum creatinine, circulating VCAM-1, ICAM-1, and hs-CRP, but lower p-selectin and HDL-C than control subjects. Except ICAM-1, cell adhesion molecules and hs-CRP levels were aroused significantly for at least 2 weeks after PTA/stenting, returned to baseline by 3 months, but p-selectin remained elevated beyond 3 months. ICAM-1 only showed a modest rise after PTA but the overall change was insignificant. In conclusion, cell adhesion molecules and hs-CRP did play a significant role in patients with advanced systemic arterial diseases who underwent PTA/stenting.
Lee
Wen Lieng
WL
Division of Cardiology, Department of Medicine, Taichung Veterans General Hospital, 160, Sec. 3, Chung-Kang Road, Taichung 407, Taiwan, ROC. wllee@vghtc.vghtc.gov.tw
Sheu
Wayne Huey-Herng
WH
Liu
Tsun-Jui
TJ
Lee
Wen-Jen
WJ
Tsao
Cheng-Rong
CR
Ju
Yong-Hua
YH
Liao
Mao-Fang
MF
Chen
Ying-Tsung
YT
Ting
Chih-Tai
CT
D000368:Aged; D000800:Angioplasty, Balloon; D001161:Arteriosclerosis / Q000276:immunology* / Q000628:therapy*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D019007:P-Selectin / Q000097:blood; D016491:Peripheral Vascular Diseases / Q000276:immunology* / Q000628:therapy*; D011184:Postoperative Period; D011446:Prospective Studies; D015607:Stents; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D015415:Biomarkers; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein