Targeting metabolic syndrome.
Metabolic syndrome has been recognised as a cluster of risk factors contributing to the development of cardiovascular diseases. Different diagnostic criteria have been proposed and the consensus focuses on four major risk factors: obesity, diabetes, dyslipidaemia and hypertension. Although treatment options are available to treat each component separately, a highly effective agent for metabolic syndrome has yet to be developed. To explore the clinical definition of metabolic syndrome and potential molecular targets that can be modulated for treatment purpose, a meeting entitled 'Targeting Metabolic Syndrome' was organised in 2004 by IBC USA Conferences, Inc. This article highlights discussions related to the clinical correlates and pathophysiology of metabolic syndrome, and reviews some of the promising drug discovery efforts. Metabolic syndrome should be treatable and preventable if obesity and insulin resistance are well controlled. New regulatory guidelines need to be developed as new treatment options are being investigated. From a broad spectrum of potential mechanisms encompassing central nervous system targets and peripheral targets for pharmacological intervention, a few promising molecular targets have emerged. Modulating these is expected to treat at least some components of metabolic syndrome.
Fong
Tung M
TM
Department of Metabolic Disorders, R80M-213, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. tung_fong@merck.com
D000818:Animals; D002144:Callithrix; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy; D004195:Disease Models, Animal; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008253:Macaca mulatta; D024821:Metabolic Syndrome / Q000209:etiology* / Q000517:prevention & control*; D051379:Mice; D009765:Obesity / Q000150:complications* / Q000188:drug therapy; D000077236:Topiramate; D015431:Weight Loss / Q000187:drug effects
D000077236:Topiramate; D005632:Fructose