Histologic behavior of the inflammatory process in autologous fat implantation in rabbit vocal folds.
Fat implantation in the vocal fold is described as a method of repairing vocal fold histostructural lesions that correlate with mucosal wave abnormalities. The aim of this study was to evaluate the histologic behavior of autologous fat implants. A fat block was implanted in pockets surgically created in the vocal folds of rabbits, and the inflammatory process induced was compared to the status of the contralateral vocal fold. Twenty-four rabbits were allocated into 3 groups to be sacrificed 1 week, 3 weeks, and 3 months after the implantation. The fat autograft did not cause any unexpected fibrosis, and we consider it a relatively safe material for implantation, with a low tendency to induce epithelial reaction and the ability to repair the histostructure of the vocal fold.
Department of Otorhinolaryngology, Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, Brazil.
André de Campos
Ade C
Duprat
Henrique Olival
HO
Costa
Carmem
C
Lancelotti
Roberta
R
Ribeiro de Almeida
Renata
R
Caron
D000273:Adipose Tissue / Q000637:transplantation*; D000818:Animals; D005355:Fibrosis; D007249:Inflammation / Q000473:pathology*; D008297:Male; D009336:Necrosis; D009389:Neovascularization, Pathologic; D011817:Rabbits; D014182:Transplantation, Autologous; D014827:Vocal Cords / Q000473:pathology* / Q000601:surgery*