Relationship between sleep-disordered breathing and blood pressure levels in community-based samples of Japanese men.
To examine the relationship between sleep-disordered breathing (SDB) and blood pressure levels among Japanese men, we conducted a population-based cross-sectional study of 1,424 men aged 40-69 years in rural and urban communities. The 3% oxygen desaturation index (ODI) was selected as the indicator of SDB, representing the number of desaturation events per hour of recording time in which blood oxygen fell by > or = 3% according to overnight pulse oximetry. To estimate the associations of 3% ODI levels with blood pressure levels and hypertension, multiple linear regression and logistic regression analyses were performed. The 3% ODI level was positively associated with systolic and diastolic blood pressure levels (SBP/DBP); a 5 event per hour increment of the 3% ODI level was associated with 0.8 mmHg (95% confidence interval [CI], 0.0-1.6) greater SBP and 0.7 mmHg (95% CI, 0.3-1.1) greater DBP after adjustment for age, body mass index, ethanol intake, smoking category and community. The multivariate odds ratio of hypertension for the low vs. high category of 3% ODI level was 1.63 (95% CI, 1.1-2.5). These associations were more evident among overweight than non-overweight individuals. The significant association of nocturnal oxygen desaturation with high blood pressure levels suggests that SDB plays a role in the development of hypertension among Japanese men.
Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan. Tt9178@aol.com
Takeshi
T
Tanigawa
Naoko
N
Tachibana
Kazumasa
K
Yamagishi
Isao
I
Muraki
Minako
M
Kudo
Tetsuya
T
Ohira
Akihiko
A
Kitamura
Shinichi
S
Sato
Takashi
T
Shimamoto
Hiroyasu
H
Iso
D000328:Adult; D000368:Aged; D044466:Asian People; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D003971:Diastole; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D016017:Odds Ratio; D010100:Oxygen / Q000097:blood; D015995:Prevalence; D012891:Sleep Apnea Syndromes / Q000097:blood / Q000150:complications / Q000208:ethnology / Q000503:physiopathology*; D013599:Systole
D010100:Oxygen