Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular health.
Vitamin K is well known for its role in the synthesis of a number of blood coagulation factors. During recent years vitamin K-dependent proteins were discovered to be of vital importance for bone and vascular health. Recommendations for dietary vitamin K intake have been made on the basis of the hepatic requirements for the synthesis of blood coagulation factors. Accumulating evidence suggests that the requirements for other functions than blood coagulation may be higher. This paper is the result of a closed workshop (Paris, November 2002) in which a number of European vitamin K experts reviewed the available data and formulated their standpoint with respect to recommended dietary vitamin K intake and the use of vitamin K-containing supplements.
Dept. of Biochemistry, University of Maastricht, P. O. Box 616, 6200 MD Maastricht, The Netherlands. c.vermeer@bioch.unimaas.nl
Cees
C
Vermeer
Martin J
MJ
Shearer
Armin
A
Zittermann
Caroline
C
Bolton-Smith
Pawel
P
Szulc
Stephen
S
Hodges
Paul
P
Walter
Walter
W
Rambeck
Elisabeth
E
Stöcklin
Peter
P
Weber
D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D001161:Arteriosclerosis; D001842:Bone and Bones / Q000378:metabolism / Q000502:physiology*; D002114:Calcinosis / Q000517:prevention & control; D019587:Dietary Supplements; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D009751:Nutritional Requirements; D015675:Osteocalcin / Q000378:metabolism; D010024:Osteoporosis / Q000517:prevention & control; D012449:Safety; D014812:Vitamin K / Q000008:administration & dosage* / Q000502:physiology*; D014813:Vitamin K Deficiency / Q000150:complications* / Q000517:prevention & control
D000933:Antifibrinolytic Agents; D015675:Osteocalcin; D014812:Vitamin K