Respiratory stimulant use in chronic obstructive pulmonary disease.
OBJECTIVE
To evaluate the use of respiratory stimulants in chronic obstructive pulmonary disease (COPD).


METHODS
MEDLINE (1966-July 2003) and EMBASE (1980-3rd quarter 2003) were searched using the search terms medroxyprogesterone acetate, acetazolamide, chronic obstructive pulmonary disease, and chronic obstructive lung disease.


RESULTS
Trials are reviewed evaluating ventilatory parameters with acetazolamide and/or medroxyprogesterone in patients with COPD. All studies found improvements in ventilatory parameters, but failed to demonstrate improvements in survival or quality of life.


CONCLUSIONS
Significant improvement in arterial blood gas and ventilatory parameters was reported in COPD patients after acetazolamide and medroxyprogesterone treatment; however, with no improvement in survival or quality of life, the place of these drugs in therapy remains unknown.
College of Pharmacy, University of Tennessee, Memphis, Knoxville, TN, USA.
Melissa J
MJ
Bales
Erin M
EM
Timpe
D000086:Acetazolamide / Q000627:therapeutic use*; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D019141:Respiratory System Agents / Q000627:therapeutic use*
D019141:Respiratory System Agents; D017258:Medroxyprogesterone Acetate; D000086:Acetazolamide