Hedgehog signaling: iguana debuts as a nuclear gatekeeper.
The intracellular pathway that controls the cytoplasmic versus nuclear distribution of Gli transcriptional regulators in response to Hedgehog signaling remains poorly understood. Iguana appears to play a role in regulating this process independently of Hedgehog signaling.
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA. vokes@mcb.harvard.edu
Steven A
SA
Vokes
Andrew P
AP
McMahon
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology; D003593:Cytoplasm / Q000502:physiology; D053823:Hedgehog Proteins; D008957:Models, Genetic; D015513:Oncogene Proteins / Q000378:metabolism / Q000502:physiology*; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*; D000071676:Zinc Finger Protein GLI1
D002352:Carrier Proteins; C488008:Dzip1 protein, zebrafish; D053823:Hedgehog Proteins; D015513:Oncogene Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1