Comparative immunopeptidomics of humans and their pathogens.
Major histocompatibility complex class I molecules present peptides of 8-10 residues to CD8+ T cells. We used 19 predicted proteomes to determine the influence of CD8+ T cell immune surveillance on protein evolution in humans and microbial pathogens by predicting immunopeptidomes, i.e., sets of class I binding peptides present in proteomes. We find that class I peptide binding specificities (i) have had little, if any, influence on the evolution of immunopeptidomes and (ii) do not take advantage of biases in amino acid distribution in proteins other than the concentration of hydrophobic residues in NH(2)-terminal leader sequences.
Istrail
Sorin
S
Celera Genomics, Rockville, MD 20850, USA. sorin.istrail@appliedbiosystems.com
Florea
Liliana
L
Halldórsson
Bjarni V
BV
Kohlbacher
Oliver
O
Schwartz
Russell S
RS
Yap
Von Bing
VB
Yewdell
Jonathan W
JW
Hoffman
Stephen L
SL
D000818:Animals; D005075:Biological Evolution; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D051379:Mice; D010446:Peptide Fragments / Q000276:immunology*; D020543:Proteome
D015395:Histocompatibility Antigens Class I; D008024:Ligands; D010446:Peptide Fragments; D020543:Proteome