[Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer].
OBJECTIVE
To investigate the association between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and risk of breast cancer among women.


METHODS
Two hundred seventeen cases with breast cancer and 218 matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by PCR-RFLP methods. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression model.


RESULTS
We found that the frequency of the MTHFR C677TT genotype among cases was significantly different from that among controls (32.7% vs. 24.8%; P = 0.02). The MTHFR C677TT genotype had an increased risk of breast cancer compared with the 677CC genotype (95% CI, 1.09 - 3.14). No significant association between the MTHFR C677T or A1298C polymorphism and risk of the cancer was observed.


CONCLUSIONS
These findings suggest that 677CT polymorphism in MTHFR may be a genetic susceptibility factor for breast cancer among Chinese women.
Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Jun
J
Qi
Xiao-ping
XP
Miao
Wen
W
Tan
Chun-yuan
CY
Yu
Gang
G
Liang
Wen-fu
WF
Lü
Dong-xin
DX
Lin
D044466:Asian People; D001943:Breast Neoplasms / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D017354:Point Mutation; D012150:Polymorphism, Restriction Fragment Length
D042965:Methylenetetrahydrofolate Reductase (NADPH2)