Brain abscesses caused by Abiotrophia defectiva: complication of immunosuppressive therapy in a patient with connective-tissue disease.
We report the case of a patient who developed brain abscesses caused by Abiotrophia defectiva. The patient was treated with prednisone and cyclophosphamide for connective-tissue disease (lupus-Sjögren's overlap syndrome). A few cases of central nervous system infections due to Abiotrophia species have been previously reported in immunocompetent patients following neurosurgical procedures, suggesting possible introduction of this organism at the time of surgery. This case report is the first report of brain abscesses due to A. defectiva in a pharmacologically immunosuppressed patient.
Department de Medecine, Centre Hospitalier de Valence, France. tzenone@ch-valence.fr
Thierry
T
Zenone
Denis Vital
DV
Durand
D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001922:Brain Abscess / Q000382:microbiology*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006095:Gram-Positive Cocci / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008177:Lupus Vulgaris / Q000188:drug therapy*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000188:drug therapy*; D013290:Streptococcal Infections / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011241:Prednisone