Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety.
Cervimycin C is the major component of an antibiotic complex produced by Streptomyces tendae HKI-179 consisting of a tetracycline-type aglycon, six tridesoxysugars and a rare dimethylmalonyl moiety. The biosynthetic origin of cervimycin was studied by molecular studies and feeding experiments, which reveal that the dimethylmalonate unit is not derived from malonate, but from valine.
Department of Biostructure Chemistry, Hans-Knoll-Institute for Natural Products Research, Beutenbergstr. 11a, 07745, Jena, Germany.
Kerstin
K
Herold
Zhongli
Z
Xu
Friedrich A
FA
Gollmick
Udo
U
Grafe
Christian
C
Hertweck
D018943:Anthracyclines / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D002240:Carbohydrate Sequence; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism*; D008314:Malonates / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013045:Species Specificity; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D018942:Macrolides; D008314:Malonates; C501538:cervimycin C; C005230:methyl malonate