[Sample size requirements for association studies on gene-gene interaction in case-control study].
OBJECTIVE
Sample size requirements for association studies on gene-gene interaction in case-control study.


METHODS
Selecting different parameters (such as inheritance mode, susceptibility frequency, frequency of allele for disease, OR of gene main effect) and infilling them into QUANTO software based on conditional logistic regression mode.


RESULTS
(1) The main parameters influencing the sample size requirements were the levels of interaction between genes and the susceptibility frequency. The numbers of sample were the same between recessive and dominant when susceptibility frequency were the same. (2) Sample size for testing of gene-gene interaction was different from that for testing of genetic effects.


CONCLUSIONS
It was convenient to use the numbers of sample size from the results for gene-gene interaction in case-control study.
Wang
Zhi-ping
ZP
College of Public Health, Shandong University, Jinan 250012, China.
Li
Hui-qing
HQ
D016022:Case-Control Studies; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008957:Models, Genetic; D019655:Quantitative Trait, Heritable; D012107:Research Design; D012307:Risk Factors; D018401:Sample Size; D012680:Sensitivity and Specificity
D005819:Genetic Markers