Controversies in the treatment of meconium aspiration syndrome.
MAS remains an infrequent but challenging condition confronting neonatologists. Avoidance of postterm pregnancies, improved intrapartum monitoring,and amnioinfusion have been beneficial. Studies have not demonstrated conclusively that any form of ventilation is superior to others, but strategies that recruit alveoli are desirable. Surfactant lavage or replacement may be beneficial. When hypoxic respiratory failure progresses, iNO may improve oxygenation and avoid ECMO.
Division of Neonatology, Department of Pediatrics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-6010, USA.
Steven L
SL
Gelfand
Jonathan M
JM
Fanaroff
Michele C
MC
Walsh
D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007231:Infant, Newborn; D007552:Isotonic Solutions / Q000008:administration & dosage; D008471:Meconium Aspiration Syndrome / Q000503:physiopathology / Q000628:therapy*; D009569:Nitric Oxide / Q000627:therapeutic use; D010092:Oximetry; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012121:Respiration, Artificial / Q000379:methods; D012307:Risk Factors; D013396:Suction; D013577:Syndrome
D007552:Isotonic Solutions; D011663:Pulmonary Surfactants; D009569:Nitric Oxide