Triterpenoids. Part 21: Oleanolic acid azaderivatives as percutaneous transport promoters.
Some new oleanolic acid derivatives with lactame and thiolactame structures in the A- or C-ring were prepared and tested as percutaneous transport promoters in vitro. Their activity was comparable with activity of N-dodecylcaprolactame (Azone). A-Thiolactame derivative of methyl oleanolate (13) was the most effective compound.
Department of Organic Chemistry, Pharmaceutical Faculty, Poznan University of Medical Sciences, Poznań, Poland.
Lucjusz
L
Zaprutko
Danuta
D
Partyka
Barbara
B
Bednarczyk-Cwynar
D000277:Adjuvants, Pharmaceutic / Q000138:chemical synthesis / Q000737:chemistry*; D000279:Administration, Cutaneous; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D001693:Biological Transport, Active; D006801:Humans; D066298:In Vitro Techniques; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry*; D008567:Membranes, Artificial; D010539:Permeability; D011374:Progesterone / Q000737:chemistry; D012869:Skin Absorption; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry*
D000277:Adjuvants, Pharmaceutic; D001372:Aza Compounds; D007769:Lactams; D008567:Membranes, Artificial; D014315:Triterpenes; C450739:oleanonic acid; D011374:Progesterone