The CC chemokine ligand 3 regulates CD11c+CD11b+CD8alpha- dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation.
The role of CC chemokine ligand 3 (CCL3) in activation of dendritic cells (DCs) following mouse hepatitis virus (MHV) infection of the central nervous system (CNS) was examined. The results indicate that CCL3 participates in an effective host response to MHV infection by contributing to CD11c+CD11b+CD8alpha- DC maturation, activation, and migration to cervical lymph nodes (CLN). Diminished CD8alpha- DC activation correlated with reduced IFN-gamma expression by virus-specific T cells accompanied by increased IL-10 production suggesting that CCL3 contributes to an effective host response to viral infection by enhancing the T cell activation potential of DC.
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.
Matthew J
MJ
Trifilo
Thomas E
TE
Lane
D000818:Animals; D001921:Brain / Q000166:cytology / Q000276:immunology / Q000821:virology; D039481:CD11b Antigen / Q000378:metabolism; D039521:CD11c Antigen / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D002454:Cell Differentiation; D002465:Cell Movement; D020805:Central Nervous System Viral Diseases / Q000276:immunology* / Q000821:virology; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018352:Coronavirus Infections / Q000276:immunology* / Q000821:virology; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D007113:Immunity, Innate; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology / Q000821:virology; D008213:Lymphocyte Activation; D019402:Macrophage Inflammatory Proteins / Q000378:metabolism*; D051379:Mice; D006517:Murine hepatitis virus / Q000235:genetics / Q000472:pathogenicity*; D013601:T-Lymphocytes / Q000276:immunology
D039481:CD11b Antigen; D039521:CD11c Antigen; D016827:CD8 Antigens; C431698:CD8alpha antigen; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins