title: Detecting acute myocardial infarction in the 12-lead ECG using Hermite expansions and neural networks.
abstract: We use artificial neural networks (ANNs) to detect signs of acute myocardial infarction (AMI) in ECGs. The 12-lead ECG is decomposed into Hermite basis functions, and the resulting coefficients are used as inputs to the ANNs. Furthermore, we present a case-based method that qualitatively explains the operation of the ANNs, by showing regions of each ECG critical for ANN response. Key ingredients in this method are: (i) a cost function used to find local ECG perturbations leading to the largest possible change in ANN output and (ii) a minimization scheme for this cost function using mean field annealing. Our approach was tested on 2238 ECGs recorded at an emergency department. The obtained ROC areas for ANNs trained with the Hermite representation and standard ECG measurements were 83.4 and 84.3% (P=0.4), respectively. We believe that the proposed method has potential as a decision support system that can provide good advice for diagnosis, as well as providing the physician with insight into the reason underlying the advice.
authors.affiliation: Department of Theoretical Physics, Lund University, Sölvegatan 14A, SE-223 62 Lund, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Haraldsson
authors.forename: Lars
authors.initials: L
authors.lastname: Edenbrandt
authors.forename: Mattias
authors.initials: M
authors.lastname: Ohlsson
mesh_terms: D000208:Acute Disease; D000368:Aged; D020000:Decision Support Systems, Clinical; D004562:Electrocardiography / Q000706:statistics & numerical data*; D001330:Electronic Data Processing; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D016571:Neural Networks, Computer