Role of the HLA-DP Glu 69 and the TNF-alpha TNF-alpha 2 gene markers in susceptibility to beryllium hypersensitivity.
Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of beryllium dusts, characterized by the accumulation of CD4+ T cells and macrophages in the lower respiratory tract. Beryllium presentation to CD4+ T cells from patients with berylliosis results in T cell activation and these Be-specific CD4+ T cells undergo clonal proliferation and Th1-type cytokine production such as interleukin-2, interferon-gamma and tumor necrosis factor-alpha. In exposed workers, genetic susceptibility to this granulomatous disorder is associated with major histocompatibility gene and the TNF-alpha gene. The HLA-DP glutamic 69 residue was shown to be the MHC genetic marker associated with disease susceptibility; furthermore the TNF-alpha TNFA-308*2 allele was found to be independently associated with HLA-DP Glu69 in the determination of berylliosis risk.
Rogliani
P
P
Dipartimento di Medicina Interna, Università di Roma Tor Vergata, Rome, Italy.
Amicosante
M
M
Berretta
F
F
Dotti
C
C
Bocchino
M
M
O'Donnell
K M
KM
Saltini
C
C
D000483:Alleles; D001607:Berylliosis / Q000235:genetics* / Q000378:metabolism; D001608:Beryllium / Q000276:immunology*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D018698:Glutamic Acid / Q000235:genetics; D006682:HLA-DP Antigens / Q000235:genetics* / Q000502:physiology; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000502:physiology
D005819:Genetic Markers; D006682:HLA-DP Antigens; D014409:Tumor Necrosis Factor-alpha; D018698:Glutamic Acid; D001608:Beryllium