title: Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy.
abstract: Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm3 after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm3 and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm3. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.
authors.affiliation: Department of Infectious Diseases, Rush Medical College of Rush University, Chicago, IL 60612, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Smith
authors.forename: Evgenia
authors.initials: E
authors.lastname: Aga
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Bosch
authors.forename: Hernan
authors.initials: H
authors.lastname: Valdez
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Connick
authors.forename: Alan
authors.initials: A
authors.lastname: Landay
authors.forename: Daniel
authors.initials: D
authors.lastname: Kuritzkes
authors.forename: Barry H
authors.initials: BH
authors.lastname: Gross
authors.forename: Isaac R
authors.initials: IR
authors.lastname: Francis
authors.forename: Joseph M
authors.initials: JM
authors.lastname: McCune
authors.forename: Harold
authors.initials: H
authors.lastname: Kessler
authors.forename: Michael
authors.initials: M
authors.lastname: Lederman
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015331:Cohort Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D011446:Prospective Studies