[Clinical outcomes of women with transfusion-associated hepatitis C after 10-15 years follow-up].
BACKGROUND
To investigate natural history of hepatitis C virus (HCV) infection and related factors in China.


METHODS
Totally 41 women infected with HCV 10-15 years ago were evaluated in this study. Their clinical manifestations were recorded and sera tested for alamine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), total protein (TP), albumin (ALB), and alpha-fetoprotein (alpha-FP), as well as virus markers. The B-type ultrasound examination was performed on the liver, gall bladder, spleen and pancreas. For virus markers, HCV RNA was detected with fluorogenic-quantitative polymerase-chain-reaction, HBsAg and anti-HCV antibody, with enzyme-linked immunosorbent assay (ELISA).


RESULTS
Ten to 15 years after infection, the infection was cleared spontaneously in 8 cases (19.51%); 73%(30/41) cases had signs at present, 32% (13/41) cases had mild ALT and/or AST elevation. On ultrasound examination, 83%(34/41) had mild degree 17%(7/41) moderate degree changes of the viral hepatitis.


CONCLUSIONS
Women with HCV infection for 13 +/- 1 (10-15) years after transfusion had slight hepatic inflammation. A part of them had cleared the virus spontaneously.
Guo
Fang
F
Hepatology Institute, Peking University Peoples Hospital, Beijing 100044, China.
Gao
Yan
Y
Wang
Qi-xin
QX
Sun
De-gui
DG
Ji
Ying
Y
Cong
Xu
X
Sun
Yan
Y
Wang
Hao
H
Wei
Lai
L
D000328:Adult; D002681:China / Q000453:epidemiology; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000635:transmission*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D065227:Transfusion Reaction
D012367:RNA, Viral