Solar ultraviolet A radiation: an oxidizing skin carcinogen that activates heme oxygenase-1.
Ultraviolet A (UVA: 320-380 nm) radiation is an oxidizing carcinogen that has proved an ideal agent for demonstrating the oxidant inducibility of the mammalian heme oxygenase-1 (HO-1) gene. The UVA response in cultured human skin fibroblasts and other cell types is mediated by singlet oxygen and is strongly influenced by cellular reducing equivalents. Free heme, an entity that can be generated by UVA irradiation of cells, also appears to be a critical intermediate that can directly influence both the transcriptional activation and repression of the HO-1 gene. Heme release is likely to be of central importance to the inflammatory response in skin and its abrogation by HO.
Tyrrell
R M
RM
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. prsrmt@bath.ac.uk
D002273:Carcinogens; D002478:Cells, Cultured; D004790:Enzyme Induction; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects; D006418:Heme / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics / Q000378:metabolism*; D051547:Heme Oxygenase-1; D006801:Humans; D008565:Membrane Proteins; D016877:Oxidants / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D012867:Skin / Q000166:cytology / Q000473:pathology / Q000528:radiation effects*; D013472:Sunlight / Q000009:adverse effects*; D014466:Ultraviolet Rays
D002273:Carcinogens; D008565:Membrane Proteins; D016877:Oxidants; D006418:Heme; C496541:HMOX1 protein, human; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; D010100:Oxygen