Effect of chronic heart failure on nuclear factor kappa B in peripheral leukocytes.
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor activated by various stimuli that are implicated in the progression of chronic heart failure. Therefore, we examined the activation of NF-kappaB in peripheral leukocytes, the only nucleated cell population noninvasively accessible in patients with heart failure. In patients with stable heart failure with no obvious other reason for NF-kappaB activation, NF-kappaB was significantly activated.
Frantz
Stefan
S
Medizinische Klinik der Universität Würzburg, Germany. frantz_s@medizin.uni-wuerzburg.de
Stoerk
Stefan
S
Ok
Sami
S
Wagner
Helga
H
Angermann
Christiane E
CE
Ertl
Georg
G
Bauersachs
Johann
J
D000368:Aged; D002908:Chronic Disease; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000096:biosynthesis* / Q000097:blood
D016328:NF-kappa B