[Pro-inflammatory chemokine IL-8 in gastroesophageal reflux disease].
Recent reports have demonstrated significantly higher expression levels of interleukin-8 (IL-8) in patients with gastroesophageal reflux disease (GERD) including non-erosive reflux disease (NERD). The levels of IL-8 mRNA expression were significantly decreased after proton pump inhibitor. The esophageal expression of CINCs, rat IL-8-like chemokines, was markedly enhanced in the models of acute or chronic esophagitis in rats. The production of IL-8 from esophageal mucosal cells was enhanced by the exposure to bile acid. These results suggest that IL-8 chemokine may play a major role in the pathogenesis of esophageal inflammation in GERD.
Naito
Yuji
Y
Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.
Yoshida
Norimasa
N
Yoshikawa
Toshikazu
T
D000818:Animals; D001471:Barrett Esophagus / Q000209:etiology; D001647:Bile Acids and Salts / Q000009:adverse effects; D019743:Chemokines, CXC / Q000235:genetics / Q000378:metabolism; D003864:Depression, Chemical; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D004942:Esophagitis, Peptic / Q000209:etiology; D004947:Esophagus / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D016209:Interleukin-8 / Q000235:genetics / Q000378:metabolism*; D009092:Mucous Membrane / Q000378:metabolism; D054328:Proton Pump Inhibitors; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats
D001647:Bile Acids and Salts; D019743:Chemokines, CXC; D004791:Enzyme Inhibitors; D018836:Inflammation Mediators; D036341:Intercellular Signaling Peptides and Proteins; D016209:Interleukin-8; D054328:Proton Pump Inhibitors; D012333:RNA, Messenger