Effects of vanadate on the activities of mice glucokinase and hexokinase.
This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV.
Xu
Ming-zhi
MZ
Department of Endocrinology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. xu921@21cn.com
Zhang
Ai-zhen
AZ
Li
Xiang-rong
XR
Xu
Wei
W
Shen
Ling-wei
LW
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005941:Glucokinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006593:Hexokinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008813:Mice, Inbred ICR; D018482:Muscle, Skeletal / Q000378:metabolism*; D016896:Treatment Outcome; D014638:Vanadates / Q000008:administration & dosage*
D001786:Blood Glucose; D007328:Insulin; D014638:Vanadates; D000496:Alloxan; D006593:Hexokinase; D005941:Glucokinase