Highly enantioselective dimerization of alpha,beta-enones catalyzed by a rigid quaternary ammonium salt.
[reaction: see text] The chiral quaternary ammonium salt 1 served as a phase-transfer catalyst for the enantioselective dimerization of alpha,beta-enones, providing a route for the asymmetric syntheses of chiral 1,5-dicarbonyl compounds and alpha-alkylated gamma-keto acids.
Zhang
Fu-Yao
FY
Department of Chemistry and Chemical Biology Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Corey
E J
EJ