Role of chemokines in Leishmania infection.
Chemokines are a growing group of chemoattractant cytokines that play important roles in physiological as well as pathological processes. Their roles in various aspects of pathogenesis and inflammation have come to light in the past decade or so. It is becoming increasingly clear that chemokines play a major, perhaps decisive role in Leishmania infections. In this review, we recapitulate important works linking the chemokine system with relation to visceral and cutaneous leishmaniasis over the past decade and attemptto put it all together to propose a single yet unfinished model to account for all the findings.
Roychoudhury
Kaushik
K
Department of Immunology, Indian Institute of Chemical Biology 4, Raja SC Mullick Road, Kolkata-700 032, India.
Roy
Syamal
S
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D018925:Chemokines / Q000378:metabolism / Q000502:physiology*; D015897:Comorbidity; D015497:HIV-1 / Q000276:immunology; D007896:Leishmaniasis / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000473:pathology; D007898:Leishmaniasis, Visceral / Q000276:immunology / Q000473:pathology; D008954:Models, Biological; D019707:Receptors, Chemokine / Q000378:metabolism
D018925:Chemokines; D019707:Receptors, Chemokine