[Application of a new type of piezo-electric immunosensor in immunology classification for acute leukemias].
The aim of this study was to apply a new type piezo-electric immunosensor in immunology classification for acute leukemia. Based on the plasma-polymerized film and the nanogold particles self-assembly technology, a new type piezo-electric immunosensor was firstly developed to absorb and fix the monoclonal antibodies for detecting leukemia cell antigens in patient blood samples. The results showed that the positive rate of detection with this method was quite close to that with the fluoroimmunoassay which are commonly used in clinic work. There was no significant difference between the positive rates (chi(2) = 3.4, P > 0.05). It is concluded that this piezo-electric immunosensor detection has many advantages, such as convenient operation, real time operation and control, qualitative detection, and less cost. This method can be used for acute leukemia immunology classification.
Zeng
Hui
H
Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China.
Wang
Hua
H
Chen
Fang-Ping
FP
Shen
Guo-Li
GL
D000208:Acute Disease; D000951:Antigens, Neoplasm / Q000032:analysis*; D015374:Biosensing Techniques / Q000379:methods*; D015200:Fluoroimmunoassay; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000276:immunology*
D000951:Antigens, Neoplasm