title: Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein abrupt.
abstract: Morphological diversity of dendrites contributes to specialized functions of individual neurons. In the present study, we examined the molecular basis that generates distinct morphological classes of Drosophila dendritic arborization (da) neurons. da neurons are classified into classes I to IV in order of increasing territory size and/or branching complexity. We found that Abrupt (Ab), a BTB-zinc finger protein, is expressed selectively in class I cells. Misexpression of ab in neurons of other classes directed them to take the appearance of cells with smaller and/or less elaborated arbors. Loss of ab functions in class I neurons resulted in malformation of their typical comb-like arbor patterns and generation of supernumerary branch terminals. Together with the results of monitoring dendritic dynamics of ab-misexpressing cells or ab mutant ones, all of the data suggested that Ab endows characteristics of dendritic morphogenesis of the class I neurons.
authors.affiliation: Laboratory of Molecular Genetics, The Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sugimura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Satoh
authors.forename: Patricia
authors.initials: P
authors.lastname: Estes
authors.forename: Stephen
authors.initials: S
authors.lastname: Crews
authors.forename: Tadashi
authors.initials: T
authors.lastname: Uemura
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D003712:Dendrites / Q000502:physiology*; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology*; D004625:Embryo, Nonmammalian; D051717:Fushi Tarazu Transcription Factors; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D049452:Green Fluorescent Proteins; D018398:Homeodomain Proteins; D007150:Immunohistochemistry / Q000379:methods; D007814:Larva; D008164:Luminescent Proteins / Q000378:metabolism; D009024:Morphogenesis / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000145:classification / Q000166:cytology* / Q000502:physiology; D009687:Nuclear Proteins / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013997:Time Factors; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors; D016335:Zinc Fingers / Q000502:physiology*
chemical_list: D029721:Drosophila Proteins; D051717:Fushi Tarazu Transcription Factors; C080545:GAL4-ftzQ protein, Drosophila; D018398:Homeodomain Proteins; D008164:Luminescent Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D011993:Recombinant Fusion Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C066381:ct protein, Drosophila; D049452:Green Fluorescent Proteins