Identification of three novel HLA class I alleles: HLA-B*3928, HLA-B*400104 and HLA-B*4437.
Three new human leukocyte antigen (HLA) class I alleles have been identified in the Tissue Typing Laboratory in Sydney, Australia. Sequence analysis of exon 2 and exon 3 of the HLA-B gene revealed the novel polymorphism. A silent substitution of C to T at nucleotide position 369 has been identified for the HLA-B*400104 allele when compared to the closest matched allele, HLA-B*400101. The HLA-B*3928 allele was identified with a nucleotide substitution of G to C at position 362 when compared to the closest matched allele, HLA-B*390101, resulting in an amino acid substitution of Arginine to Threonine. A nucleotide substitution of C to G at position 572 resulting in the amino acid change Serine to Tryptophan was identified in the new allele HLA-B*4437, when compared to the closest matched allele HLA-B*440301. Both amino acid substitutions implicate a different specificity and affinity of antigen binding for the alleles HLA-B*3928 and HLA-B*4437.
Velickovic
Z M
ZM
Molecular Genetics, Tissue Typing, Australian Red Cross Blood Service, Sydney, Australia.
Dodd
R
R
Velickovic
M
M
Hersee
J
J
Le
T
T
Taverniti
A
A
Wallace
R
R
Dunckley
H
H
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D015343:DNA Probes, HLA / Q000235:genetics*; D005091:Exons / Q000235:genetics; D014644:Genetic Variation; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D015343:DNA Probes, HLA; D015235:HLA-B Antigens