title: Concurrent cerebral american trypanosomiasis and toxoplasmosis in a patient with AIDS.
abstract: We report a case of concurrent cerebral infection with Trypanosoma cruzi and Toxoplasma gondii in a patient with acquired immunodeficiency syndrome (AIDS). A 22-year-old El Salvadoran man initially improved during receipt of antitoxoplasmosis therapy, but he had rapidly progressive hemiplegia. Magnetic resonance imaging showed an abnormal finding in the left internal capsule, and cytological analysis of cerebrospinal fluid revealed T. cruzi trypomastigotes. Despite prompt therapy with nifurtimox, the patient's mental status declined, and he died of nosocomial complications. Although infrequent, T. cruzi infection should be considered in the differential diagnosis of brain lesions in patients with AIDS from regions of endemicity.
authors.affiliation: Division of Adult Infectious Diseases, Harbor-University of California at Los Angeles Medical Center, Torrance, CA 90502, USA.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Yoo
authors.forename: Anton
authors.initials: A
authors.lastname: Mlikotic
authors.forename: Marcia E
authors.initials: ME
authors.lastname: Cornford
authors.forename: C Keith
authors.initials: CK
authors.lastname: Beck
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000818:Animals; D001921:Brain / Q000469:parasitology*; D014355:Chagas Disease / Q000175:diagnosis*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D014122:Toxoplasma / Q000302:isolation & purification*; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis*; D014349:Trypanosoma cruzi / Q000302:isolation & purification*