title: Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures.
abstract: CNS levels of the cytokine interleukin-6 (IL-6) are elevated during CNS injury and disease, but it is unclear if IL-6 contributes to the pathologic process. Our studies show that in a well-characterized CNS developmental model system, primary cultures of rodent cerebellar granule neurons, chronic exposure to IL-6 during neuronal development can result in cell damage and death in a subpopulation of developing granule neurons. Chronic exposure to IL-6 also increased the susceptibility of the granule neurons to a toxic insult produced by excessive activation of NMDA receptors. These results are consistent with a role for IL-6 in the neuropathology observed in the developing CNS during injury and disease.
authors.affiliation: Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Conroy
authors.forename: Vi
authors.initials: V
authors.lastname: Nguyen
authors.forename: Lely A
authors.initials: LA
authors.lastname: Quina
authors.forename: Penney
authors.initials: P
authors.lastname: Blakely-Gonzales
authors.forename: Christina
authors.initials: C
authors.lastname: Ur
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Netzeband
authors.forename: Anne L
authors.initials: AL
authors.lastname: Prieto
authors.forename: Donna L
authors.initials: DL
authors.lastname: Gruol
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D016923:Cell Death / Q000187:drug effects / Q000276:immunology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002525:Cerebellar Cortex / Q000166:cytology / Q000276:immunology*; D004347:Drug Interactions / Q000502:physiology; D015850:Interleukin-6 / Q000276:immunology / Q000633:toxicity*; D016202:N-Methylaspartate / Q000633:toxicity; D009474:Neurons / Q000187:drug effects* / Q000276:immunology; D009498:Neurotoxins / Q000276:immunology / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000276:immunology
chemical_list: D015850:Interleukin-6; D009498:Neurotoxins; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate