Comparison of fluorimetric, voltammetric and biosensor methods for the determination of total antioxidant capacity of drug products containing acetylsalicylic acid.
Antioxidant capacity of several drug specialities containing as mean component acetylsalicylic acid were experimentally evaluated using an enzymatic electrode, recently developed by the present authors, based on superoxide dismutase (SOD) enzyme. The precision of this method of analysis was found to be good (for drug samples RSD < or = 5%). The results were also compared with those ones by a traditional spectrofluorimetric method and by two other methods, respectively, based on cyclic and pulsed voltammetry, recently trialled by the present authors.
Campanella
L
L
Department of Chemistry, University of Rome La Sapienza, Piazzale Aldo Moro, 5 00185 Rome, Italy.
Bonanni
A
A
Bellantoni
D
D
Favero
G
G
Tomassetti
M
M
D000975:Antioxidants / Q000032:analysis* / Q000592:standards; D001241:Aspirin / Q000032:analysis* / Q000592:standards; D015374:Biosensing Techniques; D004563:Electrochemistry; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000592:standards; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence; D013482:Superoxide Dismutase / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014969:Xanthine Oxidase / Q000737:chemistry
D000975:Antioxidants; D004364:Pharmaceutical Preparations; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D001241:Aspirin