Electrochemical study of zolpidem at glassy carbon electrode and its determination in a tablet dosage form by differential pulse voltammetry.
The oxidative behaviour of, a hypnotic drug, zolpidem was studied at glassy carbon electrode in Britton-Robinson buffer over the pH range 2.0-11.0 using cyclic, linear sweep and differential pulse voltammetry. Oxidation of the drug was effected in a single irreversible, diffusion-controlled step. Using differential pulse voltammetry (DPV), the drug yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 8.0 at +0.889 V (vs. Ag/AgCl) on glassy carbon electrode. This process could be used to determine zolpidem concentrations in the range 5.0 x 10(-7) M to 1.0 x 10(-5) M with a detection limit of 2.0 x 10(-7) M. The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form.
Radi
Abd-Elgawad
AE
Department of Chemistry, Faculty of Science (Dumyat), Mansoura University, 34517 Dumyat, Egypt. abdradi@yahoo.com
Bekhiet
Gamal
G
Wahdan
Tarek
T
D002244:Carbon; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D006993:Hypnotics and Sedatives / Q000737:chemistry; D010084:Oxidation-Reduction; D011725:Pyridines / Q000032:analysis / Q000737:chemistry*; D013607:Tablets / Q000032:analysis; D000077334:Zolpidem
D006993:Hypnotics and Sedatives; D011725:Pyridines; D013607:Tablets; D002244:Carbon; D000077334:Zolpidem