title: Medical treatment of ruptured with hemodynamically stable and unruptured ectopic pregnancy patients.
abstract: OBJECTIVE
  To determine the success rate of methotrexate treatment of ruptured ectopic pregnancy with hemodynamically stable and unruptured ectopic pregnancy patients.
  
  
  METHODS
  This prospective clinical study was carried out on 161 patients with suspected tubal ectopic pregnancy. Fourty-six patients have been accepted as ruptured ectopic pregnancy with hemodynamically stable and 115 patients have been accepted as unruptured ectopic pregnancy. All patients diagnosed with ectopic pregnancy were treated by single dose (50 mg/m2) methotrexate if they have stable hemodynamia and fulfill the criteria of methotrexate treatment. Weekly beta-hCG level was measured and if this level was under 10 IU/L, the treatment has been accepted as successful. Mann-Whitney and Fisher's exact tests were used (SPSS, 10.0) for statistical analysis.
  
  
  RESULTS
  The success rates of methotrexate treatments in ruptured ectopic pregnancy patients with hemodynamically stable and in patients with unruptured ectopic pregnancy were observed as 62% and 81%, respectively (P < 0.001). The treatment was successfully completed in all expectant management patients.
  
  
  CONCLUSIONS
  Although methotrexate treatment of ruptured ectopic pregnancy with hemodynamically stable patients is not as successful as in unruptured ectopic pregnancy group, 62% success rate in this group may promise a treatment choice before surgery application.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ataturk University, 25200 Erzurum, Turkey. ykumtepe@atauni.edu.tr
authors.forename: Yakup
authors.initials: Y
authors.lastname: Kumtepe
authors.forename: Sedat
authors.initials: S
authors.lastname: Kadanali
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000328:Adult; D001794:Blood Pressure; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D006339:Heart Rate; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D011446:Prospective Studies; D012422:Rupture, Spontaneous; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D018997:Chorionic Gonadotropin, beta Subunit, Human; D008727:Methotrexate