title: [The expressions of Ki67 and VEGF in squamous cell carcinoma of larynx and the correlation between the two marks].
abstract: OBJECTIVE
  To investigate the expression of Ki67 and VEGF in squamous cell carcinoma of larynx and the correlation between Ki67 and VEGF.
  
  
  METHODS
  The expression of Ki67 and VEGF in squamous cell carcinoma of larynx tissues of 40 cases were studied by immunohistochemical staining.
  
  
  RESULTS
  The expression of Ki67 and VEGF in squamous cell carcinoma of larynx tissues were higher than those in mucosa of laryngeal cavity (P<0.01). The expression of the two marks in squamous cell carcinoma of larynx with the metastasis of lymph nodes were higher than those without metastasis (Ki67: P<0.05, VEGF: P<0.01). Age and sex did not change the expression obviously (P>0.05). There was a positive correlation between T-stage and immunohistochemical staining (P<0.05). There was also a positive correlation in staining intensity between Ki67 and VEGF (r = 0.823, P<0.01).
  
  
  CONCLUSIONS
  Ki67 and VEGF are objective marks to estimate the behaviors of squamous cell carcinoma of larynx, and they can do help to the diagnosis, the judgment of stages and the treatment of carcinoma of larynx.
authors.affiliation: Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Sun
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Weijia
authors.initials: W
authors.lastname: Kong
authors.forename: Banghua
authors.initials: B
authors.lastname: Liu
authors.forename: Xiong
authors.initials: X
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Sulin
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D042442:Vascular Endothelial Growth Factors / Q000096:biosynthesis*
chemical_list: D019394:Ki-67 Antigen; D042442:Vascular Endothelial Growth Factors