Long-term effect of CPAP in the treatment of nocturnal stridor in multiple system atrophy.
The authors found that continuous positive airway pressure (CPAP) eliminated video-polysomnographic documented stridor in 13 multiple system atrophy (MSA) subjects with vocal cord abnormalities. Long-term follow-up showed high CPAP tolerance, no recurrence of stridor, no major side effects, subjective improvement in sleep quality, and that median survival time was similar to a group of 26 MSA patients without stridor. This study shows that in MSA, CPAP is an effective noninvasive long-term therapy for nocturnal stridor.
Iranzo
A
A
Neurology Service, Hospital Clínic and Instisut d'Investigació Biomèdiques August Pi i Sunyer, Barcelona, Spain. airanzo@clinic.ub.es
Santamaria
J
J
Tolosa
E
E
Vilaseca
I
I
Valldeoriola
F
F
Martí
M J
MJ
Muñoz
E
E
D000368:Aged; D045422:Continuous Positive Airway Pressure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications* / Q000401:mortality; D012135:Respiratory Sounds / Q000209:etiology; D020919:Sleep Disorders, Intrinsic / Q000209:etiology / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome