Low CD4+ T-lymphocyte values in human immunodeficiency virus-negative adults in Botswana.
CD4+-lymphocyte counts (LCs) play a crucial role in the management and monitoring of HIV infection. Variability in CD4+ LCs has been reported to occur as a result of measurement techniques and/or biological variations. We report on the CD4+ LCs of healthy human immunodeficiency virus (HIV)-seronegative adults in Botswana. Samples were obtained from HIV-seronegative blood donors. The median CD4+ LC was 726 cells/mm3 (for females, 782 cells/mm3; for males, 698 cells/mm3). The median CD8+ LC was 488 cells/mm3 (for females, 494 cells/mm3; for males, 485 cells/mm3). The median CD4+-to-CD8+ ratio was 1.57 (for females, 1.66; for males, 1.51). Our findings of low CD4+ LCs among HIV-negative adults in Botswana are significant and have important implications for the management of HIV disease in the population of this sub-Saharan African country.
Bussmann
Hermann
H
Botswana-Harvard AIDS Partnership, Gaborone, Botswana.
Wester
C William
CW
Masupu
Kereng V
KV
Peter
Trevor
T
Gaolekwe
Sarah M
SM
Kim
Soyeon
S
Reich
Ann Marie
AM
Ahn
Sam
S
Wu
Ying
Y
Thior
Ibou
I
Essex
Max
M
Marlink
Richard
R
D000328:Adult; D001902:Botswana / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology*; D005260:Female; D015658:HIV Infections / Q000175:diagnosis; D018023:HIV Seronegativity; D006801:Humans; D008297:Male; D012016:Reference Values; D018571:Sentinel Surveillance