title: Plasma levels of thrombin activatable fibrinolysis inhibitor in normal and preeclamptic pregnant women.
abstract: To explain the pathogenesis of preeclampsia with coagulation induction or a defective fibrinolysis, various hemostatic parameters were studied and different treatment modalities targeting these parameters were evaluated. Considering the role of TAFI in down-regulation of fibrinolysis, in our study we have investigated whether TAFI contributes to impaired fibrinolysis in patient with preeclampsia. Thirty patients with preeclampsia (mean age +/- SD 25.7 +/- 4.53; range 17-36) and 30 normal pregnant women as control group (mean age +/- SD 28 +/- 5.26; range 21-38) were included in our study. TAFI antigen was determined using an ELISA kit for quantitative measurement. The mean TAFI antigen levels were 12.55 +/- 1.88 microg/ml in patients with preeclampsia and 12.29 +/- 3.0 microg/ml in normal pregnant women. A statistically significant difference was not found between TAFI antigen levels of two groups (p > 0.05). In order to clarify the role of TAFI in the pathogenesis of preeclampsia, in addition to plasma TAFI levels, its synthesis, activation and metabolism should also be evaluated.
authors.affiliation: Division of Hematology, Institute of Oncology, Dokuz Eylul University, 35340 Izmir, Turkey.
authors.forename: Inci
authors.initials: I
authors.lastname: Alacacioğlu
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Ozcan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alacacioğlu
authors.forename: Mesut
authors.initials: M
authors.lastname: Polat
authors.forename: Faize
authors.initials: F
authors.lastname: Yüksel
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirkan
authors.forename: Ozden
authors.initials: O
authors.lastname: Pişkin
authors.forename: Yiğit
authors.initials: Y
authors.lastname: Ozgenç
authors.forename: Hayri Güner
authors.initials: HG
authors.lastname: Ozsan
authors.forename: Bulent
authors.initials: B
authors.lastname: Undar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D025901:Carboxypeptidase B2 / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy / Q000097:blood*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D025901:Carboxypeptidase B2