title: Bullous herpes zoster in a child with leukemia: case report and review of the literature.
abstract: Blistering disorders in childhood are usually difficult to diagnose and pose complicated management dilemmas. The incidence of herpes zoster in children with malignancy and immunodeficiency is greatly increased compared to normal children of comparable age. Although herpes zoster is known to occur in children with malignancy, the bullous form of herpes zoster is rare; to the authors' knowledge, there was no previous report of this phenomenon in children in general and in children with cancer in particular. The authors describe a 3.5-year-old girl who was diagnosed with acute lymphoblastic leukemia; 7 months after presentation, during chemotherapy treatment, she developed the bullous form of herpes zoster on her right hand. The authors describe the method of diagnosis and provide a review of the literature concerning this rare phenomenon. Recognizing this entity and differentiating it from other bullomatous conditions enable the application of appropriate treatment, without unnecessary delay.
authors.affiliation: Department of Pediatric Hemato-Oncology, Meyer Children's Hospital, Rambam Medical Center, Haifa, Israel. morx@netvision.net.il
authors.forename: Motti
authors.initials: M
authors.lastname: Haimi
authors.forename: Myriam Weyl
authors.initials: MW
authors.lastname: Ben-Arush
authors.forename: Imad
authors.initials: I
authors.lastname: Kassis
authors.forename: Sergey
authors.initials: S
authors.lastname: Postovsky
authors.forename: Zipi
authors.initials: Z
authors.lastname: Kra-Oz
authors.forename: Ronit
authors.initials: R
authors.lastname: Elhasid
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006562:Herpes Zoster / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D000212:Acyclovir