Hypercalcemia in prostate cancer with positive neuron-specific enolase stain.
Hypercalcemia is a common complication of malignant diseases with or without bone metastasis. Hypercalcemia in prostate cancer is rarely seen. The exact mechanism of prostate cancer-related hypercalcemia is still uncertain. Secretion of parathyroid hormone-related peptides (PTH-rP) is thought to be one of the possible mechanisms. We reported a rare case of prostate cancer with hypercalcemia (13 mg/dL). Bone marrow biopsy showed metastatic adenocarcinoma. The cells were also positive for neuron-specific enolase, which is the specific marker for neuroendocrine cell. The finding suggested that the prostate cancer cell derived from the neuroendocrine cell, which might synthesize PTH-rP and be responsible for the observed hypercalcemia.
Wu
Ching-Heng
CH
Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Lan
Yii-Jenq
YJ
Wang
Cheng-Hsu
CH
Wu
Mai-Szu
MS
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001853:Bone Marrow / Q000201:enzymology / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000473:pathology / Q000556:secondary*; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000150:complications*
D010751:Phosphopyruvate Hydratase