title: [Rapidly lethal progression of a therapy-resistant status epilepticus].
abstract: We present a case of death after first manifestation of generalised convulsive status epilepticus in a young man. A previously healthy 23-year-old man was admitted to our emergency department by ambulance service with approximately 20 min of generalised convulsive seizures. First line treatment in the emergency ward with benzodiazepines failed. The patient was cardiopulmonary stable until, after more than 30 min of status epilepticus, he developed tachycardia and became bradypnoeic. Intubation and ventilation was performed and anticonvulsive treatment was escalated with thiopental. Fifteen minutes later he developed ventricular fibrillation. CPR was started. The patient became asystolic after 90 min CPR following the ILCOR (International Liaison Committee on Resuscitation) Instructions. CPR was continued for another 30 min without success. The patient died after 120 min of maximal efforts. Autopsy and toxicology were performed, neuropathologic examination showed general brain edema and neuronal cell loss in purkinje cell layers of the cerebellum and olive knots which may be the consequence of generalised convulsive status epilepticus. We conclude: status epilepticus becomes refractory in approximately 30 % of cases. Until now, there are no randomised trials on the optimal treatment of refractory status epilepticus. Better treatment algorithms are urgently needed.
authors.affiliation: Klinik für Anästhesiologie und Intensivmedizin, Notfallmedizin, Schmerztherapie, Universitätsklinikum Charité, Campus Mitte, Berlin.
authors.forename: M
authors.initials: M
authors.lastname: Nolte
authors.forename: M
authors.initials: M
authors.lastname: Holtkamp
authors.forename: A
authors.initials: A
authors.lastname: Stroehmann
authors.forename: T
authors.initials: T
authors.lastname: Schröder
authors.forename: W
authors.initials: W
authors.lastname: Kox
authors.forename: C
authors.initials: C
authors.lastname: Spies
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D001784:Blood Gas Analysis; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000473:pathology; D016887:Cardiopulmonary Resuscitation; D004351:Drug Resistance; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D011689:Purkinje Cells / Q000473:pathology; D013226:Status Epilepticus / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D014693:Ventricular Fibrillation / Q000209:etiology / Q000628:therapy
chemical_list: D000927:Anticonvulsants; D001569:Benzodiazepines