A decade of adult liver transplantation in a single center in Chile.
BACKGROUND
Since the early days, liver transplantation (OLT) has conquered several barriers worldwide to become a proven therapy. We assessed the evolution of our adult liver transplant program.


METHODS
We studied all adult patients who underwent OLT since the inception from November 1993 through May 2003. Donor data, recipient pretransplantation evaluation, surgical technique, results, and costs were examined over our evolution, stratifying 3 groups over time, based on the number of adult OLT per year.


RESULTS
Between November 1993 and May 2003, 70 OLT were performed in 64 patients older than 15 years of age. Preoperative Child score, preoperative creatinine level, donor and recipient age, and proportion of emergencies were similar in the 3 groups. Over time, the predominant surgical technique was the piggyback technique (97% of OLT) with a decrease in the use of bypass from 63% to 5% during the last time period. Over the 10 years of our program's existence, warm ischemia time has been reduced to less than 1 hour, whereas cold ischemia time has remained constant at around 5 hours. Biliary and vascular complications decreased over time to around 10%. The mean length of hospital stay (LOS) decreased to 12 days (excluding emergencies). Since inception, our 1-year patient survival rate average is 91%; however, in just the last 3 years of our program (2000 through 2003), the 1-year patient survival rate is 97%.


CONCLUSIONS
In summary, our surgical technique has evolved toward piggyback use without veno-venous bypass with a significant decrease in warm ischemia times. As expected, our results have improved over time and our LOS and costs have decreased. Finally, our current results are similar to the best ones reported in the medical literature today.
Innocenti
F
F
Department of Surgery, Transplant Unit, Clinica Alemana Santiago, Santiago, Chile. finnocenti@alemana.cl
Hepp
J
J
Zapata
R
R
Sanhueza
E
E
Humeres
R
R
Ríos
H
H
Suárez
L
L
Palacios
J M
JM
Quiroga
M
M
Rodríguez
G
G
Abarca
J
J
Montalván
C
C
Zaror
M
M
Valderrama
R
R
Niedmann
J P
JP
Rius
M
M
D000328:Adult; D002677:Chile; D003404:Creatinine / Q000097:blood; D006801:Humans; D016031:Liver Transplantation / Q000379:methods / Q000502:physiology / Q000706:statistics & numerical data*; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome
D003404:Creatinine