[Yeast as a model for studying the prion and amyloid occurrence].
Recent data on the use of yeast as a model for studying the molecular basis of prion infection are summarized. In contrast to mammalian prions, which are related to incurable neurodegenerative diseases, yeast prions determine the appearance of non-chromosomally inherited phenotypic traits. Prions of yeast are structurally similar to amyloids of mammals and their replication involves not only growth, but also fragmentation of prion amyloid-like fibrils. In mammals the fragmentation should lead to an increase in infectious titer. The use of yeast for study of the mechanisms of human amyloidoses, development of new anti-prion drugs and search for new proteins with prion properties is described.
Kryndushkin
D S
DS
Aleksandrov
I M
IM
Kushnirov
V V
VV
Ter-Avanesian
M D
MD
D000682:Amyloid / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D017096:Prion Diseases / Q000378:metabolism* / Q000473:pathology; D011328:Prions / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
D000682:Amyloid; D018832:Molecular Chaperones; D011328:Prions; D029701:Saccharomyces cerevisiae Proteins