title: [Plasminogen activator of urokinase-type: mechanisms of involvement in vessel remodeling and angiogenesis, gene therapy approaches to ischemia].
abstract: The review summarizes data obtained by the authors and other laboratories concerning the role of urokinase plasminogen activator in vessel remodeling and angiogenesis. The data have shown that urokinase is involved in unfavorable vascular remodeling during the development of restenosis, atherosclerosis and also in the regulation of angiogenesis. Urokinase is a promising target for therapeutic interventions aimed at restenosis prevention. Urokinase gene therapy may be a perspective strategy for the treatment of tissue ischemia.
authors.forename: E V
authors.initials: EV
authors.lastname: Parfenova
authors.forename: V V
authors.initials: VV
authors.lastname: Plekhanova
authors.forename: V V
authors.initials: VV
authors.lastname: Stepanova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Men'shikov
authors.forename: Z I
authors.initials: ZI
authors.lastname: Tsokaleva
authors.forename: K A
authors.initials: KA
authors.lastname: Talitskiĭ
authors.forename: T M
authors.initials: TM
authors.lastname: Rakhmat-zade
authors.forename: D O
authors.initials: DO
authors.lastname: Traktuev
authors.forename: N A
authors.initials: NA
authors.lastname: Torosian
authors.forename: N I
authors.initials: NI
authors.lastname: Rogunova
authors.forename: E I
authors.initials: EI
authors.lastname: Ratner
authors.forename: V A
authors.initials: VA
authors.lastname: Tkachuk
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology / Q000628:therapy*; D015316:Genetic Therapy; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000628:therapy*; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000235:genetics; D010960:Plasminogen Activators / Q000008:administration & dosage* / Q000235:genetics; D051381:Rats; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage* / Q000235:genetics
chemical_list: D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator