title: Peripheral neuropathy--a rare complication of paediatric systemic lupus erythematosus.
abstract: Peripheral neuropathy is an uncommon complication in paediatric systemic lupus erythematosus (SLE). We report the case of a 10-year-old Chinese girl who developed peripheral neuropathy within 3 months of the onset of SLE and presented with bilateral foot drop and sensory symptoms of both hands and feet. There was no involvement of the central nervous system at the time of presentation. The patient was negative for anticardiolipin antibodies, but positive for lupus anticoagulant. She was treated with intravenous methylprednisolone followed by oral steroids, methotrexate, gabapentin and amitryptyline. Although peripheral neuropathy is a rare complication of paediatric systemic lupus erythematosus, one should be vigilant for this entity as part of the neurological spectrum. It may not be associated with involvement of the central nervous system. Antiphospholipid antibodies may have role in the pathogenesis of SLE associated peripheral neuropathy. We speculate that routine nerve conduction studies may have a role in detecting sub-clinical cases.
authors.affiliation: Department of Paediatrics, Leicester Royal Infirmary, University Hospitals of Leicester NHS trust, Leicester LEI 5WW, UK. sa135@le.ac.uk
authors.forename: A V
authors.initials: AV
authors.lastname: Sridhar
authors.forename: J
authors.initials: J
authors.lastname: Gosalakkal
authors.forename: I F
authors.initials: IF
authors.lastname: Pye
authors.forename: P
authors.initials: P
authors.lastname: Houtman
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D020886:Somatosensory Disorders / Q000175:diagnosis / Q000209:etiology / Q000628:therapy