title: The complete coding region sequence of river buffalo (Bubalus bubalis) SRY gene.
abstract: The Y-linked SRY gene is responsible for testis determination in mammals. Mutations in this gene can lead to XY Gonadal Dysgenesis, an abnormal sexual phenotype described in humans, cattle, horses and river buffalo. We report here the complete river buffalo SRY sequence in order to enable the genetic diagnosis of this disease. The SRY sequence was also used to confirm the evolutionary divergence time between cattle and river buffalo 10 million years ago.
authors.affiliation: Istituto SperimentaleItaliano Lazzaro Spallanzani, Lab. Epigenetica Applicata, Fondazione Parco Tecnologico Padano, Via Giovanni XXIII, 726900, Lodi, Italy. parma@unipv.it
authors.forename: Pietro
authors.initials: P
authors.lastname: Parma
authors.forename: Maria
authors.initials: M
authors.lastname: Feligini
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Greppi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Enne
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002020:Buffaloes / Q000235:genetics*; D002417:Cattle; D004268:DNA-Binding Proteins / Q000235:genetics*; D006041:Goats; D006059:Gonadal Dysgenesis / Q000235:genetics* / Q000662:veterinary*; D006736:Horses; D006801:Humans; D008297:Male; D008322:Mammals; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics*; D010802:Phylogeny; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D051876:Sex-Determining Region Y Protein; D012756:Sheep; D013737:Testis; D014157:Transcription Factors / Q000235:genetics*; D014907:Whales / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors