Follow-up measurements of Nevirapine plasma levels over a prolonged period.
Over a period of more than four years of treatment, 177 Nevirapine plasma levels were taken from 27 patients. The values showed a high inter-patient variability and a lower intra-patient variability. Differences in body weight turned out to be the main reason for inter-patient variability. Treatment over a prolonged period did not result in any change in plasma concentrations. Adjusting dosage by means of therapeutic drug monitoring would appear to be a reasonable way of maximising patient benefit from treatment.
Sienz
M
M
University of Wuerzburg, Division of Infectious Diseases, Medical Policlinic, Josef-Schneider-Str. 2, D-97080 Wuerzburg, Germany.
Zilly
M
M
Ebigbo
A
A
Knipper
A
A
Winzer
R
R
Klinker
H
H
Langmann
Peter
P
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D001835:Body Weight; D016903:Drug Monitoring; D005260:Female; D005500:Follow-Up Studies; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D019829:Nevirapine / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D013997:Time Factors
D019380:Anti-HIV Agents; D019829:Nevirapine