title: Are adverse skin reactions to cosmetics underestimated in the clinical assessment of contact dermatitis? A prospective study among 1075 patients attending Swedish patch test clinics.
abstract: It is known that cosmetics and skin care products can cause adverse skin reactions. However, the frequency of adverse reactions reported to the Medical Product Agency (MPA) in Sweden is low. The purpose of the present study was to evaluate the occurrence of adverse skin reactions to cosmetics among patients referred for standard patch testing owing to suspected contact dermatitis in general, most frequently hand eczema. Consecutive patients at four patch test clinics in Sweden were invited to participate; 1075 were included. Of these, 47.3% (54.2% women and 30.8% men) reported current or previous adverse skin reactions to cosmetics and skin care products. This group showed significantly more positive patch test reactions, a higher prevalence of atopic dermatitis and the dermatitis was more frequently located in the face and neck region. Our results show that patients referred for standard patch testing have--or have had--a large proportion of self-reported adverse reactions to cosmetics or skin care products. We conclude that among patients with suspected contact dermatitis, adverse reactions to cosmetics can be a more important aetiological and/or complicating factor than is commonly acknowledged and that the reporting of such reactions to the MPA probably can be improved.
authors.affiliation: Department of Medicine, Occupational and Environmental Dermatology, Karolinska Institutet, Stockholm, Sweden. magnus.lindberg@smd.sll.se
authors.forename: Magnus
authors.initials: M
authors.lastname: Lindberg
authors.forename: Monica
authors.initials: M
authors.lastname: Tammela
authors.forename: Asa
authors.initials: A
authors.lastname: Boström
authors.forename: Torkel
authors.initials: T
authors.lastname: Fischer
authors.forename: Annica
authors.initials: A
authors.lastname: Inerot
authors.forename: Karin
authors.initials: K
authors.lastname: Sundberg
authors.forename: Berit
authors.initials: B
authors.lastname: Berne
mesh_terms: D000485:Allergens / Q000009:adverse effects; D000554:Ambulatory Care Facilities; D000704:Analysis of Variance; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D010328:Patch Tests; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology
chemical_list: D000485:Allergens; D003358:Cosmetics