Synthesis of diazepinones via intramolecular transamidation.
[structure: see text] The synthesis of a collection of bicyclic fused azepinones via an intramolecular beta-lactam ring-opening strategy is reported. Depending on the chirality of the various inputs, complete stereocontrol of product formation is achieved.
Vasudevan
Anil
A
Enabling Chemistry Technologies, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA. anil.vasudevan@@abbott.com
Villamil
Clara I
CI
Djuric
Stevan W
SW