title: [Modern antidepressants in complex management of patients with hypertension and concomitant affective disorders].
abstract: According to results of multiple studies depression and anxiety are found in more than 50% of patients with hypertension. Presence of affective disorders elevates risk of progression of hypertension. That is why complex therapy comprising antihypertensive drugs from various groups and antidepressants takes on higher and higher significance. Modern antidepressants produce no substantial cardiotoxic effects. Combination of an antihypertensive drug (angiotensin converting enzyme inhibitor captopril or beta-adrenoblocker metoprolol) with an antidepressant affects favorably clinical course of hypertension, 24-hour blood pressure profile, characteristics of intracardiac hemodynamics, structural and geometric left ventricular parameters, allows to achieve sufficient antihypertensive effect with acceptable tolerability.
authors.affiliation: Moscow State Medical Dental University; ul. Delegatskaya 20, 103473 Moscow, Russia.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Vasiuk
authors.forename: E A
authors.initials: EA
authors.lastname: Nesterova
authors.forename: T V
authors.initials: TV
authors.lastname: Dovzhenko
authors.forename: A A
authors.initials: AA
authors.lastname: Kozina
authors.forename: I A
authors.initials: IA
authors.lastname: Sadulaeva
authors.forename: K V
authors.initials: KV
authors.lastname: Tarasova
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000928:Antidepressive Agents; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D019964:Mood Disorders
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D002216:Captopril