title: [Relationship between overexpression of facilitative glucose transporter-1 and fluorodeoxyglucose uptake in primary human lung adenocarcinoma].
abstract: OBJECTIVE
  To assess the relationship between the overexpression of facilitative glucose transporter-1 (Glut1) and fluorine-18 fluorodeoxyglucose (FDG) uptake in patients with primary lung adenocarcinoma.
  
  
  METHODS
  From April 1999 to March 2001, 24 patients with lung adenocarcinoma were imaged with FDG positron emission tomography (PET) before surgery. Their maximum and mean standard uptake value (SUVmax and SUVmean) of tumor and SUV of normal lung (SUVlung) were measured. The expression of Glut1 of all 24 cases was studied in paraffin sections by SP immunohistochemistry.
  
  
  RESULTS
  All 23 tumors tested were Glut1 positive. (35 +/- 23)% of tumor cell area was positive and staining intensity was (3.7 +/- 0.9). All tumors of the patients could be detected by FDG-PET. FDG uptake of tumor was higher than that of normal lung (P < 0.01). SUVmax, SUVmean and SUVlung were (5.46 +/- 3.32), (4.05 +/- 2.54) and (0.43 +/- 0.15) respectively. Correlations were found among Glut1 expression and FDG uptake and tumor size (P < 0.01).
  
  
  CONCLUSIONS
  Glut1 overexpression is universal in the lung adenocarcinoma and correlate with FDG uptake.
authors.affiliation: Department of Thoracic Surgery, General Hospital of the Chinese People's Liberation Army, Beijing 100853, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Yu-e
authors.initials: YE
authors.lastname: Sun
authors.forename: Shu-lin
authors.initials: SL
authors.lastname: Yao
authors.forename: Jia-he
authors.initials: JH
authors.lastname: Tian
authors.forename: Xiao-bing
authors.initials: XB
authors.lastname: Liu
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012189:Retrospective Studies
chemical_list: D051272:Glucose Transporter Type 1; D019788:Fluorodeoxyglucose F18