A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase.
A 5-year-old girl presented with a painful abdominal mass. Abdominal magnetic resonance imaging (MRI) showed 3 separate masses. Tumor markers including lactate dehydrogenase (LDH), cancer antigen-125 (CA-125), beta-subunit of human chorionic gonadotropin (beta-hCG) and neuron-specific enolase (NSE) were elevated. At operation, the main tumor arose from the left ovary and was associated with torsion, whereas the other lesions were lymph node metastases. A salpingo-oophorectomy was performed. Histopathologic examination indicated that the tumor was a dysgerminoma. Immunohistochemicallly, the cells were positive for NSE and placental alkaline phosphatase (PALP) but were negative for CA-125, beta-hCG, S-100, glial fibrillary acidic protein, and vimentin. The elevated serum levels of tumor markers improved dramatically after the operation and chemotherapy.
Tatekawa
Yukihiro
Y
Department of Pediatric Surgery, Ibaraki Children's Hospital, Futabadai, Mito, Japan.
Kemmotsu
Hisao
H
Mouri
Takeshi
T
Joe
Kazuya
K
Ohkawa
Haruo
H
D000469:Alkaline Phosphatase / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers; D001761:Bleomycin / Q000008:administration & dosage; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D016190:Carboplatin / Q000008:administration & dosage; D002675:Child, Preschool; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004407:Dysgerminoma / Q000097:blood / Q000737:chemistry / Q000188:drug therapy / Q000201:enzymology* / Q000601:surgery; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009363:Neoplasm Proteins / Q000032:analysis* / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood / Q000737:chemistry / Q000188:drug therapy / Q000201:enzymology* / Q000601:surgery; D010052:Ovariectomy; D010751:Phosphopyruvate Hydratase / Q000032:analysis* / Q000097:blood; D014102:Torsion Abnormality / Q000209:etiology; D014747:Vinblastine / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000032:analysis
D015415:Biomarkers; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D018997:Chorionic Gonadotropin, beta Subunit, Human; D007527:Isoenzymes; D009363:Neoplasm Proteins; D000509:alpha-Fetoproteins; D001761:Bleomycin; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin; C027260:pirarubicin; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase; D010751:Phosphopyruvate Hydratase