title: Intracoronary verapamil rapidly terminates reperfusion tachyarrhythmias in acute myocardial infarction.
abstract: BACKGROUND
  The restoration of coronary flow after transient ischemia immediately induces life-threatening ventricular tachyarrhythmias. Although most of these arrhythmias disappear spontaneously, some of them induce serious hemodynamic changes. This retrospective study investigates the efficacy of therapy with intracoronary verapamil to terminate reperfusion-induced ventricular tachyarrhythmias in patients with acute myocardial infarction (AMI).
  
  
  RESULTS
  Between February 1992 and February 2003, 390 patients with a diagnosis of AMI were enrolled into the study. All patients received mechanical revascularization therapy within 6 h of onset of symptoms, and 109 patients experienced reperfusion-induced tachyarrhythmias. A subset of these patients was treated with intracoronary verapamil (0.25 to 1.0 mg) to terminate the reperfusion-induced tachyarrhythmia. They were evaluated for immediate termination of the tachyarrhythmias, hemodynamic changes, resumption rates, and major complications. Thirty-one patients (28%) were treated with intracoronary verapamil for the immediate termination of reperfusion-induced ventricular tachyarrhythmias. These tachyarrhythmias included 6 premature ventricular contractions, 19 accelerated idioventricular rhythms, 3 ventricular tachycardias, 2 ventricular fibrillations (VFs), and 1 torsades de pointes. Intracoronary verapamil was effective in rapidly terminating all reperfusion-induced arrhythmias except for VFs. The side effects of treatment included temporary hypotension (two patients) and bradycardia (one patient), although all patients recovered spontaneously. No major complications were induced by the intracoronary use of verapamil, and no resumptions of arrhythmias were documented.
  
  
  CONCLUSIONS
  Intracoronary administration of verapamil can safely terminate reperfusion-induced ventricular tachyarrhythmias in a rapid manner. However, this effect was not seen for reperfusion-induced VF.
authors.affiliation: Department of Cardiology, Hiroshima City Asa Hospital, 2-1-1 Kabeminami, Asakita-ku, Hiroshima 731-0293, Japan. ms-katou@asa-hosp.city.hiroshima.jp
authors.forename: Masaya
authors.initials: M
authors.lastname: Kato
authors.forename: Keigo
authors.initials: K
authors.lastname: Dote
authors.forename: Shota
authors.initials: S
authors.lastname: Sasaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takemoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Habara
authors.forename: Daiji
authors.initials: D
authors.lastname: Hasegawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000009:adverse effects; D006328:Cardiac Catheterization; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000628:therapy; D015427:Reperfusion Injury / Q000188:drug therapy*; D012189:Retrospective Studies; D017180:Tachycardia, Ventricular / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D014700:Verapamil / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D014700:Verapamil