title: The effect of indocyanine green pretreatment on the parameters of transscleral diode laser thermotherapy-induced threshold coagulation of the ciliary body.
abstract: OBJECTIVE
  To study the effect of indocyanine green (ICG) pretreatment on threshold parameters of transscleral diode laser thermotherapy-induced threshold coagulation of the ciliary body. The procedure was termed 'cyclothermotherapy' based on the long duration (15-60 seconds) of diode laser application.
  
  
  METHODS
  The right eyes of nine young adult New Zealand white rabbits underwent transscleral cyclothermotherapy (TCT, Group 1), TCT following ICG pretreatment (Group 2), and external manipulation of the ciliary body alone (Group 3). Rabbits were sacrificed after 24 hours; specimens were evaluated with gross examination and light microscopy.
  
  
  RESULTS
  Thresholds were 30 J/cm2 (TCT) and 4.5 J/cm2 (TCT with ICG). Widespread structural damage was seen in the ciliary processes and the ciliary body in Groups 1 and 2. In Group 3, external manipulation of the ciliary body caused hemorrhage and structural damage confined to the ciliary processes.
  
  
  CONCLUSIONS
  ICG pretreatment reduced the energy necessary to cause a threshold lesion with TCT in nonpigmented rabbits.
authors.affiliation: The Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.
authors.forename: Po-Cheng
authors.initials: PC
authors.lastname: Kuo
authors.forename: Gholam A
authors.initials: GA
authors.lastname: Peyman
authors.forename: Gamze
authors.initials: G
authors.lastname: Men
authors.forename: Yanno
authors.initials: Y
authors.lastname: Bezerra
authors.forename: Franco
authors.initials: F
authors.lastname: Torres
mesh_terms: D000818:Animals; D002924:Ciliary Body / Q000187:drug effects / Q000601:surgery*; D007208:Indocyanine Green / Q000494:pharmacology*; D017075:Laser Coagulation; D011300:Preoperative Care; D011817:Rabbits
chemical_list: D007208:Indocyanine Green