Reversible cerebellar lesions induced by metronidazole therapy for helicobacter pylori.
Metronidazole is widely used for chronic or refractory infection and has recently also been used for the treatment of Helicobacter pylori. The authors report the case of a Japanese patient presenting with reversible cerebellar lesions induced by prolonged administration of metronidazole for treatment of H pylori with magnetic resonance imaging findings. Although rare, prolonged and high-dose administration of metronidazole may induce cerebellar lesions. Increased awareness of this phenomenon is important, as these lesions are reversible with discontinuation of this drug.
Ito
Hirono
H
Division of Neurology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan. sipin@med.toho-u.ac.jp
Maruyama
Michiyuki
M
Ogura
Naoko
N
Fujioka
Toshiki
T
Iwasaki
Yasuo
Y
Aikawa
Atsushi
A
Hasegawa
Akira
A
D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002526:Cerebellar Diseases / Q000139:chemically induced*; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008279:Magnetic Resonance Imaging; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
D000890:Anti-Infective Agents; D008795:Metronidazole