title: Bone destruction resulting from rupture of a cholesteatoma sac: temporal bone pathology.
abstract: OBJECTIVE
  The purpose of the current study was to research the pathogenesis of bony destruction of cholesteatoma.
  
  
  METHODS
  We conducted a case report.
  
  
  METHODS
  The study was performed at Fukushima Medical University.
  
  
  METHODS
  The first case involved a 21 trisomy, whereas the second case was cancer of the hypopharynx. Both cases showed cholesteatoma.
  
  
  RESULTS
  The following histopathologic findings in the temporal bones of cholesteatoma were obtained. Bony destruction in cholesteatoma was detected in the lesion of the rupture of the cholesteatoma sac. Epithelial debris of cholesteatoma was scattered throughout the rupture of the cholesteatoma sac. Rupture of the matrix was the result of a small abscess.
  
  
  CONCLUSIONS
  Rupture of the cholesteatoma sac was believed to have been a pathway of either endogenous substances from the matrix and/or epithelial debris of cholesteatoma.
authors.affiliation: Department of Otolaryngology, Fujita General Hospital, Fukushima, Japan. ccsuzuki@fmu.ac.jp
authors.forename: Chiaki
authors.initials: C
authors.lastname: Suzuki
authors.forename: Iwao
authors.initials: I
authors.lastname: Ohtani
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications; D002781:Cholesteatoma / Q000473:pathology*; D004314:Down Syndrome / Q000150:complications; D004429:Ear Ossicles / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D012422:Rupture, Spontaneous / Q000473:pathology; D013701:Temporal Bone / Q000473:pathology*