[Changes in the ultrastructure of the stomach mucous membrane parietal cells caused by inhibitors of hydrochloric acid secretion].
The study of the action of phamotidine and omeprazol on the stomach parietal cells in patients with duodenal ulcer has shown that phamotidin results in changes of secretory membrane of the parietal cells increasing its secretory potential while omeprazol reduces energetic metabolism of the lining cell by the impact on its mitochondrial apparatus. Both in children and adults with duodenal ulcer more developed mitochondrial cell activity was found after omeprazol treatment.
Dondukova
G V
GV
Morozov
I A
IA
D000293:Adolescent; D000328:Adult; D002648:Child; D015738:Famotidine / Q000494:pharmacology / Q000627:therapeutic use; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006635:Histamine H2 Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009853:Omeprazole / Q000494:pharmacology / Q000627:therapeutic use; D010295:Parietal Cells, Gastric / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D054328:Proton Pump Inhibitors
D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D015738:Famotidine; D009853:Omeprazole