title: Management of postoperative follow-up and surgical treatment for Krukenberg tumor from colorectal cancers.
abstract: OBJECTIVE
  The purpose of this retrospective study was to evaluate the clinical presentation as well as surgical intervention for ovarian metastasis from colorectal cancers identified during postoperative follow-up.
  
  
  METHODS
  Nine cases of ovarian metastasis were observed among 452 female patients with colon cancers between 1990 and 2000. Initial symptoms were pain (67%), pelvic mass (50%), vaginal bleeding (33%), and uterine bleeding (17%). On pathological evaluation, six cases (67%) were found to be moderately differentiated, and three (33%) well differentiated adenocarcinomas.
  
  
  RESULTS
  Early diagnosis is very difficult. The growth of metastatic ovarian tumors are slow in elder patients, its growth is rapid in younger patients, and frequently diagnosed as huge ovarian tumors. In some cases, as cystic ovarian lesions they were identified in their early stage but could not be diagnosed as ovarian metastases, later curative operation could not be performed. The consulting gynecologist could not reach the correct diagnosis. Regular postoperative pelvic CT or MRI should be helpful for diagnosis. Although serum CEA levels did not increase in most cases, tumor markers CA125 and SLX were elevated in several cases, and thus may be useful for the detection of ovarian metastases. Surgical treatment consisted of bilateral and unilateral salpingo-oophorectomy or pelvic exenteration and additional hysterectomy for one patient because of association with cervical cancer. The median survival time after the primary operation was 20.8 months, ranging from 3 to 96 months. Peritoneal dissemination and bone metastases were frequently observed as recurrence after these operations. Two cases (non-synchronous solitary metastasis or direct involvement, located in the pelvis) survived more than 5 years (85 and 96 months, respectively), and both patients were treated with pelvic exenteration.
  
  
  CONCLUSIONS
  This suggests that in general most cases with ovarian metastasis have a poor prognosis and that radical operation such as pelvic exenteration can improve survival only in cases of recurrent solitary ovarian metastasis or local extended disease, i.e. when the lesion is located only in the pelvis.
authors.affiliation: Department of Digestive Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Chouhei
authors.initials: C
authors.lastname: Sakakura
authors.forename: Akeo
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Junya
authors.initials: J
authors.lastname: Yamazaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takagi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hosokawa
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shimomura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kin
authors.forename: Yuen
authors.initials: Y
authors.lastname: Nakase
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Fukuda
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Yamagishi
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D007725:Krukenberg Tumor / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D010052:Ovariectomy; D011379:Prognosis; D016019:Survival Analysis