[Dose-dependent effects of morphine hydrochloride on glycolysis in the rat liver].
The effect of acute morphine intoxication (10, 20 and 40 mg/kg body weight) on the functioning of glycolysis in the rat liver was studied. The most pronounced effect was noted at the dose of 10 mg/kg. It included activation of key glycolytic enzymes: hexokinase, glucokinase and phosphofructokinase and increase blood and liver tissue glucose being increased. The elevated morphine dose did not change glycolytic enzyme activities, decreasing glucose and glucose-6-phosphate contents.
Lelevich
S V
SV
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D005941:Glucokinase / Q000378:metabolism; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009294:Narcotics / Q000008:administration & dosage / Q000494:pharmacology*; D025221:Phosphofructokinases / Q000378:metabolism; D051381:Rats
D009294:Narcotics; D009020:Morphine; D025221:Phosphofructokinases; D006593:Hexokinase; D005941:Glucokinase