Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis. The elevated expression of these proteins in tumor cells and their post-translational modifications, such as phosphorylation, acetylation and methylation, are discussed and suggested as suitable targets for cancer chemotherapy.
Sgarra
Riccardo
R
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, via L. Giorgieri 1, Università di Trieste, 34127 Trieste, Italy.
Rustighi
Alessandra
A
Tessari
Michela A
MA
Di Bernardo
Julie
J
Altamura
Sandro
S
Fusco
Alfredo
A
Manfioletti
Guidalberto
G
Giancotti
Vincenzo
V
D000107:Acetylation; D000595:Amino Acid Sequence; D017209:Apoptosis / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D002843:Chromatin / Q000737:chemistry*; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000502:physiology*; D008745:Methylation; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000503:physiopathology*; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid
D002843:Chromatin; D006609:High Mobility Group Proteins