title: Transient pancytopenia preceding T lineage acute lymphoblastic leukemia.
abstract: Transient pancytopenia preceding acute lymphoblastic leukemia (pre-ALL) is a rare occurrence usually affecting children with subsequent development of B lineage ALL. We report a case of pre-ALL characterized by a T cell immunophenotype and abnormal karyotype t (11; 14) (q10; q10). The patient achieved a transient complete remission after initial therapy, but relapsed within a few months and died of leukemic encephalopathy. To the best of our knowledge, this is the first report of T lineage pre-ALL.
authors.affiliation: Department of Thrombosis and Hemostasis, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Zhu
authors.forename: Yumei
authors.initials: Y
authors.lastname: Chen
authors.forename: Yao
authors.initials: Y
authors.lastname: Zou
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Renchi
authors.initials: R
authors.lastname: Yang
authors.forename: Zhong Chao
authors.initials: ZC
authors.lastname: Han
mesh_terms: D019070:Cell Lineage / Q000276:immunology; D002648:Child; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D010198:Pancytopenia / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D013601:T-Lymphocytes