Dynamic infrared imaging for the detection of malignancy.
The potential for malignancy detection using dynamic infrared imaging (DIRI) has been investigated in an animal model of human malignancy. Malignancy was apparent in images formed at the vasomotor and cardiogenic frequencies of tumour bearing mice. The observation of malignancy was removed by the administration of an agent that blocks vasodilation caused by nitric oxide (NO). Image patterns similar to those that characterize malignancy could be mimicked in normal mice using an NO producing agent. Apparently DIRI allows for cancer detection in this model through vasodilation caused by malignancy generated NO. Dynamic infrared detection of vasomotor and cardiogenic surface perfusion was validated in human subjects by a comparison with laser Doppler flowmetry (LDF). Dynamic infrared imaging technology was then applied to breast cancer detection. It is shown that dynamic infrared images formed at the vasomotor and cardiogenic frequencies of the normal and malignant breast have image pattern differences, which may allow for breast cancer detection.
Button
Terry M
TM
Department of Radiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA. tbutton@radiol.som.sunysb.edu
Li
Haifang
H
Fisher
Paul
P
Rosenblatt
Ruth
R
Dulaimy
Khaldoon
K
Li
Song
S
O'Hea
Brian
B
Salvitti
Mathew
M
Geronimo
Veronica
V
Geronimo
Christine
C
Jambawalikar
Sachin
S
Carvelli
Paola
P
Weiss
Richard
R
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017078:Laser-Doppler Flowmetry; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D005996:Nitroglycerin / Q000494:pharmacology; D010477:Perfusion; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013997:Time Factors
D009569:Nitric Oxide; D005996:Nitroglycerin