title: Pancreaticoduodenectomy for pancreatic metastases from breast carcinoma.
abstract: BACKGROUND
  Unlike primary pancreatic carcinoma, metastases to the pancreas are rare events and their resection may be performed as a palliative treatment. The aim of this study was to review our experience with the operative management of pancreatic metastases from breast carcinoma.
  
  
  METHODS
  Three patients underwent pancreaticoduodenectomy for pancreatic metastases from breast carcinoma between 1990 and 2002. The clinical features of and the results after resection were examined. The presenting clinical symptoms were jaundice, pain and weight loss. In all cases, the pancreatic metastases were solitary lesions located in the head of the pancreas and the intervals between the primary breast carcinoma and the pancreatic metastases were 3, 5 and 7 years. The primary tumor was lobular carcinoma. Metastases were initially misdiagnosed as primary cancers. All patients underwent pancreaticoduodenectomy. One patient died from disseminated metastatic disease 26 months after surgery. The other two patients are alive 37 and 21 months after pancreaticoduodenectomy; the second one has had recurrence of the disease.
  
  
  CONCLUSIONS
  In rare cases, the pancreas may be the presenting site for breast metastases, typically years after treating the primary tumor. Pancreaticoduodenectomy can be performed in the absence of extreme metastatic disease; it can provide worthwhile palliation and improve survival.
authors.affiliation: Department of Surgery, University of Milan-Bicocca, San Gerardo Hospital, Monza, MI, Italy. ste.crippa@libero.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Crippa
authors.forename: Claudia
authors.initials: C
authors.lastname: Bonardi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bovo
authors.forename: Chiara
authors.initials: C
authors.lastname: Mussi
authors.forename: Carlo
authors.initials: C
authors.lastname: Angelini
authors.forename: Franco
authors.initials: F
authors.lastname: Uggeri
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods*