title: beta-Chitin-based wound dressing containing silver sulfurdiazine.
abstract: Physical and biological properties of some wound dressing materials based on beta-chitin were studied. Water vapor transmission rates (WVTR), oxygen permeabilities and biodegradation kinetics were examined for film-type samples. WVTR of samples was in the range 2400-2800 g/m2/day. However, oxygen permeabilities of the samples were relatively low. To improve oxygen permeabilities, porous sponge-type wound dressing materials were prepared. In addition, these sponge-type samples contained antimicrobial agents, silver sulfadiazine (AgSD), in order to prevent bacteria infection on a wound surface. Anti-microbacterial tests on agar plate were carried out to confirm the bactericidal capacity of present materials. These materials impregnating AgSD had the complete bactericidal capacity against pseudomonas aeruginosa up to 7 days. Finally, a wound healing effect of beta-chitin-based semi-interpenetrating polymer networks was evaluated from the animal test using the wistar rat in vivo. Histological studies confirm the proliferation of fibroblasts in the wound bed and a distinct reduction in infectious cells.
authors.affiliation: School of Chemical Engineering, College of Engineering, Hanyang University, Seoul 133-791, Korea. ymlee@email.hanyang.ac.kr
authors.forename: Y M
authors.initials: YM
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Kim
authors.forename: M H
authors.initials: MH
authors.lastname: Park
authors.forename: K W
authors.initials: KW
authors.lastname: Song
authors.forename: Y K
authors.initials: YK
authors.lastname: Sung
authors.forename: I K
authors.initials: IK
authors.lastname: Kang