Modeling of dispersed-drug release from two-dimensional matrix tablets.
A mathematical model was developed and analytical solutions were obtained for dispersed-drug release from two-dimensional matrix tablets in a perfect sink. This model can be used to describe kinetics of solute release from matrices with isotropic or anisotropic properties. Moving boundaries of dispersed-drug in both radial and axial directions and release kinetics were predicted by the model. Various factors influencing release kinetics were analyzed including the ratio of initial solute loading (C0) to solute solubility (Cs), the anisotropy of the matrix and the aspect ratio of tablet radius to the half-thickness. The model is also applicable to 1-D planar or 1-D cylindrical geometries when R/H is larger than 100 or smaller than 0.01.
Zhou
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Y
AP-CAD Inc., Toronto, Ontario, Canada M2N 3X2.
Chu
J S
JS
Zhou
T
T
Wu
X Y
XY
D003627:Data Interpretation, Statistical; D016503:Drug Delivery Systems; D007700:Kinetics; D008962:Models, Theoretical; D013997:Time Factors