title: Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1.
abstract: Hepatitis C virus (HCV) quasispeciation was studied in two children vertically coinfected with HCV and human immunodeficiency virus type 1 (HIV-1). HCV quasispecies diversification and liver injury were more significant in patient C1, who was immunocompetent with anti-HIV therapy, than in patient C2, who was immunosuppressed, in consistency with modulation of HCV quasispeciation and liver injury by immunocompetence in coinfected children.
authors.affiliation: Unité d'immunopathologie virale, Centre de recherche de l'Hôpital Sainte-Justine, 3175 Côte Sainte-Catherine, Room 6735, Montréal (Québec) H3T 1C5, Canada.
authors.forename: Sophie
authors.initials: S
authors.lastname: Canobio
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Guilbert
authors.forename: Myriam
authors.initials: M
authors.lastname: Troesch
authors.forename: Johanne
authors.initials: J
authors.lastname: Samson
authors.forename: Mireille
authors.initials: M
authors.lastname: Lemay
authors.forename: Veronique Anne
authors.initials: VA
authors.lastname: Pelletier
authors.forename: Anne-Claude
authors.initials: AC
authors.lastname: Bernard-Bonnin
authors.forename: Rafal
authors.initials: R
authors.lastname: Kozielski
authors.forename: Normand
authors.initials: N
authors.lastname: Lapointe
authors.forename: Steven R
authors.initials: SR
authors.lastname: Martin
authors.forename: Hugo
authors.initials: H
authors.lastname: Soudeyns
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000635:transmission; D023241:Antiretroviral Therapy, Highly Active; D002648:Child; D018450:Disease Progression; D005260:Female; D016174:Hepacivirus / Q000145:classification*; D006526:Hepatitis C / Q000150:complications / Q000473:pathology* / Q000635:transmission; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008099:Liver / Q000473:pathology; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology