Determination of sensitive positions to mutations in human p53 protein.
Over last several years, we demonstrated that the mutations are more likely to occur at randomly unpredictable amino acid pairs in a protein. We therefore can in principle predict the amino acid pairs sensitive to the future mutations in a protein. However, we still need to predict the positions at which the sensitive amino acid pairs are located in a protein. In this study, we use a probabilistic approach to analyze the effect of 191 mutations in human p53 protein and can approximately estimate the sensitive positions to mutations in human p53 protein.
Wu
Guang
G
Computational Mutagen Project, DreamSciTech Consulting Co. Ltd., 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province, CN-518054, China. hongguanglishibahao@yahoo.com
Yan
Shaomin
S
D006801:Humans; D016296:Mutagenesis / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D011336:Probability; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry* / Q000235:genetics*
D016159:Tumor Suppressor Protein p53