Neurophysiologic findings in early acute inflammatory demyelinating polyradiculoneuropathy.
BACKGROUND
Patients with early acute inflammatory demyelinating polyradiculoneuropathy (AIDP) may not meet the current neurophysiologic criteria.


OBJECTIVE
To document neurophysiologic findings in early AIDP.


METHODS
Clinical and neurophysiologic data from 38 AIDP patients, assessed within 10 days of symptom onset were reviewed.


RESULTS
In addition to absent H reflexes and abnormal F-wave responses in the acute stage of AIDP, abnormalities of blink reflexes, upper limb sensory responses abnormalities with spared sural responses, presence of distal CMAP dispersion, and A-waves were frequently observed. Established demyelinating neurophysiologic parameters were infrequently seen.


CONCLUSIONS
Abnormalities of H reflexes and F responses were most frequently noted in early AIDP. Additionally, distal temporal dispersion, prolonged or absent blink reflexes, and A-waves were often present in the acute stage of AIDP when classic diagnostic criteria of AIDP were not satisfied.


CONCLUSIONS
Neurophysiologic studies in early AIDP frequently reveal abnormalities that are not specific of primary demyelinating neuropathy.
Vucic
Steve
S
Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Cairns
Kevin D
KD
Black
Kristin R
KR
Chong
Peter Siao Tick
PS
Cros
Didier
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001767:Blinking / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004558:Electric Stimulation; D004576:Electromyography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000503:physiopathology*; D006181:H-Reflex / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009460:Neurologic Examination; D012189:Retrospective Studies