title: Reversal of cardiac abnormalities in a young man with idiopathic hypereosinophilic syndrome using a tyrosine kinase inhibitor.
abstract: We report a case of idiopathic hypereosinophilic syndrome in a young man, who showed symptoms and electrocardiographic findings mimicking an acute coronary syndrome. Two-dimensional echocardiography, together with laboratory data, allowed us to make the diagnosis and to start a treatment with imatinib mesylate, a 2-phenylamonopyrimidine-based tyrosine kinase inhibitor, which reversed the cardiac abnormalities.
authors.affiliation: Division of Cardiology, S. Maria di Loreto Hospital, Viale dei Pini 4, 80055 Portici, Naples, Italy. luigi.ascione20@tin.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Ascione
authors.forename: Mario
authors.initials: M
authors.lastname: De Michele
authors.forename: Maria
authors.initials: M
authors.lastname: Accadia
authors.forename: Pasquale
authors.initials: P
authors.lastname: Spadaro
authors.forename: Salvatore
authors.initials: S
authors.lastname: Rumolo
authors.forename: Bernardino
authors.initials: B
authors.lastname: Tuccillo
mesh_terms: D000328:Adult; D001549:Benzamides; D003937:Diagnosis, Differential; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D000068877:Imatinib Mesylate; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate