Effectiveness of two annual, single-dose mass drug administrations of diethylcarbamazine alone or in combination with albendazole on soil-transmitted helminthiasis in filariasis elimination programme.
A longitudinal community-trial on the control of soil-transmitted helminths (STHs), as part of a lymphatic filariasis elimination campaign, was taken up in two revenue blocks of southern India in the years 2001 and 2002 to assess the impact of two annual single-dose mass drug administration (MDA) of diethylcarbamazine (DEC) + albendazole (ALB) with that of DEC alone. The prevalences and intensities of STHs were studied among cross-sectional samples of school children aged 9-10 years by using the Kato-Katz technique at baseline and 11 months after each MDA. The combined drug mass treatment produced a higher reduction in the prevalence (RIP) (51-77%) and the egg reduction rate (ERR) (92-98%) compared with 12-15% RIP and 58-62% ERR of DEC alone mass treatment. The effect of two-drug therapy after two annual treatments was relatively long lasting as shown by RIP and ERR indicating that the reinfection rates were relatively lower in this approach than single-drug therapy. This study demonstrates that mass drug co-administration of DEC + ALB in Global Programme for Elimination of Lymphatic Filariasis (GPELF) targeted at the community had a synergistic and sustainable effect against soil-transmitted helminthiasis and provided considerable 'beyond filariasis' benefits. The additional advantages accrued to the community underscore the importance of scaling-up GPELF to cover the entire population at risk.
Mani
T R
TR
Centre for Research in Medical Entomology, Madurai, India. crmeicmr@satyam.net.in
Rajendran
R
R
Sunish
I P
IP
Munirathinam
A
A
Arunachalam
N
N
Satyanarayana
K
K
Dash
A P
AP
D015766:Albendazole / Q000008:administration & dosage*; D000871:Anthelmintics / Q000008:administration & dosage*; D002648:Child; D003430:Cross-Sectional Studies; D004049:Diethylcarbamazine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004605:Elephantiasis, Filarial / Q000453:epidemiology / Q000517:prevention & control*; D006373:Helminthiasis / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D015995:Prevalence; D016896:Treatment Outcome
D000871:Anthelmintics; D015766:Albendazole; D004049:Diethylcarbamazine