[Effect of the joint administration of ketamine and propofol on the lipid metabolism and peroxidation in rats].
Ketamine (50 mg/kg, i.p.) increases the intensity of lipolysis and lipid peroxidation (LPO) in the hepatic and cardiac tissues of Wistar male rats, as manifested by an increase in the content of nonetherified fatty acids and cholesterol in the blood serum and in the content of LPO products in the blood serum and in the liver and heart tissues. Propofol in the same dose also influences the lipid metabolism and LPO intensity, but to a lower extent. The joint administration of both ketamine (25 mg/kg, i.p.) and propofol (25 mg/kg, i.p.) leads to averaging of some characteristics of the lipid metabolism and LPO.
Abidova
S S
SS
Ishankulova
G F
GF
D019162:Anesthetics, Combined / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D007649:Ketamine / Q000494:pharmacology*; D050356:Lipid Metabolism; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D007649:Ketamine; D015742:Propofol