title: Pulmonary vascular pressures of strenuously exercising Thoroughbreds after administration of varying doses of frusemide.
abstract: The frusemide dose-response for attenuation of exercise-induced pulmonary capillary hypertension was studied in 7 healthy, exercise-conditioned Thoroughbred horses using previously described haemodynamic procedures. Four different doses of frusemide were tested: 250 mg regardless of bodyweight (amounting to 0.56 +/- 0.03 mg/kg bwt), 1.0 mg/kg bwt, 1.5 mg/kg bwt and 2.0 mg/kg bwt. Frusemide was administered i.v., 4 h before exercise. Haemodynamic data were obtained at rest and during treadmill exercise performed at 14.2 m/s on a 3.5% uphill grade; this workload elicited maximal heart rate of horses. Airway endoscopy was performed post exercise to detect exercise-induced pulmonary haemorrhage (EIPH). In standing horses, frusemide administration resulted in a significant (P<0.05) decrease in mean pulmonary arterial, pulmonary capillary and pulmonary artery wedge pressures, but significant differences among the various frusemide doses were not observed. In the control experiments, exercise caused significant increments in the right atrial as well as pulmonary arterial, wedge, and capillary pressures, and all horses experienced EIPH. Following frusemide administration, the exercise-induced rise in right atrial and pulmonary vascular pressures was significantly attenuated, but significant differences between the frusemide doses of 250 mg, 1.0 mg/kg, and 1.5 mg/kg were not discerned and all horses remained positive for EIPH. Although a further significant (P<0.05) attenuation of the exercise-induced rise in pulmonary capillary blood pressure occurred when frusemide dose increased from 250 mg to 2.0 mg/kg bwt, all horses still experienced EIPH. It is concluded that a linear response to increasing frusemide dosage in terms of attenuation of the pulmonary capillary hypertension does not exist in strenuously exercising Thoroughbred horses.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: M
authors.initials: M
authors.lastname: Manohar
authors.forename: T E
authors.initials: TE
authors.lastname: Goetz
authors.forename: E
authors.initials: E
authors.lastname: Sullivan
authors.forename: R
authors.initials: R
authors.lastname: Griffin
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D018592:Cross-Over Studies; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test / Q000662:veterinary; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006734:Horse Diseases / Q000517:prevention & control*; D006736:Horses; D006976:Hypertension, Pulmonary / Q000517:prevention & control / Q000662:veterinary*; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D011652:Pulmonary Circulation / Q000187:drug effects / Q000502:physiology; D011897:Random Allocation
chemical_list: D004232:Diuretics; D005665:Furosemide