Uterine smooth-muscle tumor of uncertain malignant potential metastasizing to the humerus as a high-grade leiomyosarcoma.
BACKGROUND
Smooth-muscle tumors of uncertain malignant potential represent a variant of uterine leiomyoma and remain a dilemma due to their uncertain clinical behavior. Most of these tumors have a benign clinical course, and coagulative tumor cell necrosis has usually been associated with worse outcome.


METHODS
We present a case of a uterine smooth-muscle tumor (SMT) of uncertain malignant potential without coagulative tumor cell necrosis that has metastasized to the humerus. The metastatic lesion was a high-grade leiomyosarcoma consistent with uterine origin.


CONCLUSIONS
Smooth-muscle tumors of uncertain malignant potential that demonstrate a lack of coagulative tumor cell necrosis do not necessarily insure benign clinical outcome. These lesions can recur and metastasize to distant sites, thus requiring long-term follow-up.
Shapiro
Adam
A
Division of Gynecologic Oncology, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2. adam.shapiro1@mail.mcgill.ca
Ferenczy
Alex
A
Turcotte
Robert
R
Bruchim
Ilan
I
Gotlieb
Walter H
WH
D001859:Bone Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D006811:Humerus / Q000473:pathology; D007889:Leiomyoma / Q000473:pathology*; D007890:Leiomyosarcoma / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery