title: Cost-effectiveness analysis of colorectal cancer screening strategies in Singapore: a dynamic decision analytic approach.
abstract: A dynamic decision analytic framework using local statistics and expert's opinions is put to study the cost-effectiveness of colorectal cancer screening strategies in Singapore. It is demonstrated that any of the screening strategies, if implemented, would increase the life expectancy of the population of 50 to 70 years old. The model also determined the normal life expectancy of this population to be 76.32 years. Overall, Guaiac Fecal Occult Blood Test (FOBT) is most cost effective at SGD162.11 per life year saved per person. Our approach allowed us to model problem parameters that change over time and study the utility measures like cost and life expectancy for specific age within the range of 50- 69 through to 70 years old.
authors.affiliation: School of Computing, National University of Singapore, 3 Science Drive, Singapore 117543, Singapore. wongss@comp.nus.edu.sg
authors.forename: Swee Seong
authors.initials: SS
authors.lastname: Wong
authors.forename: Adrian Peng Kheong
authors.initials: AP
authors.lastname: Leong
authors.forename: Tze-Yun
authors.initials: TY
authors.lastname: Leong
mesh_terms: D000368:Aged; D001466:Barium Sulfate; D003113:Colonoscopy / Q000191:economics; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000191:economics; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D004733:Enema / Q000191:economics; D005260:Female; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008390:Markov Chains; D008403:Mass Screening / Q000191:economics*; D008875:Middle Aged; D009780:Occult Blood; D012812:Sigmoidoscopy / Q000191:economics; D012846:Singapore
chemical_list: D001466:Barium Sulfate