title: Primary adrenal insufficiency in patients with acquired immunodeficiency syndrome: report of four cases.
abstract: Adrenal insufficiency, though rare, is a well-known complication of acquired immunodeficiency syndrome (AIDS). Over the past 9 years at the National Taiwan University Hospital, 4 patients were diagnosed with primary adrenal insufficiency among 854 non-hemophiliac patients with human immunodeficiency virus infection, with an incidence of 0.19 per 100 patient-years (95% confidence interval, 0.17-0.21 per 100 patient-years). All of the 4 patients were severely immunosuppressed and had been diagnosed with at least 1 AIDS-defining opportunistic illness ever reported to produce adrenal insufficiency in AIDS patients. In 1 of the patients, fluconazole was considered contributory to the development of adrenal insufficiency after treatment at a daily dose of 800 mg for 68 days.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Huang
authors.forename: Ching-Chung
authors.initials: CC
authors.lastname: Chang
authors.forename: Hsin-Yun
authors.initials: HY
authors.lastname: Sun
authors.forename: Mao-Yuan
authors.initials: MY
authors.lastname: Chen
authors.forename: Chien-Ching
authors.initials: CC
authors.lastname: Hung
authors.forename: Shan-Chwen
authors.initials: SC
authors.lastname: Chang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000309:Adrenal Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects; D015725:Fluconazole / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013624:Taiwan
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole