Kaposi's sarcoma-associated herpesvirus immediate early gene activity.
KSHV is the causative agent of three human proliferative disorders: Kaposi s sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Herpesvirus gene expression and viral replication is a complex, tightly regulated process involving latent, immediate early, early, and late viral gene transcription. The immediate early genes generally code for transcriptional activators and are critical for initiating viral transcription. KSHV encodes for approximately nine immediate early gene products, including ORF50, K8, K9, K3, K5, ORF57, ORF29b, ORF45, and K4.2. This review will address the activities of these proteins and what roles they play in virus replication, evasion of the host immune response, and viral pathogenesis.
Lacoste
Vincent
V
Department of Biochemistry and Molecular Biology, The George Washington University, Washington, District of Columbia 20037, USA.
de la Fuente
Cynthia
C
Kashanchi
Fatah
F
Pumfery
Anne
A
D000818:Animals; D017209:Apoptosis; D050976:Basic-Leucine Zipper Transcription Factors / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D017781:Genes, Immediate-Early; D016679:Genome, Viral; D019288:Herpesvirus 8, Human / Q000378:metabolism*; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics* / Q000502:physiology*; D007107:Immune System; D016366:Open Reading Frames; D010766:Phosphorylation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015534:Trans-Activators / Q000235:genetics* / Q000502:physiology*; D015533:Transcriptional Activation; D014764:Viral Proteins / Q000235:genetics* / Q000502:physiology*; D014779:Virus Replication
D050976:Basic-Leucine Zipper Transcription Factors; D002843:Chromatin; D017874:Immediate-Early Proteins; C417604:Rta protein, Human herpesvirus 8; D015534:Trans-Activators; D014764:Viral Proteins