Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids.
A series of indole alkaloids of the ibogan-type was assessed for their cytotoxic effects as well as their potential in reversing MDR in vincristine-resistant KB cells. Of a total of 25 compounds tested, 3(S)-cyanocoronaridine, 3(S)-cyanoisovoacangine, 3(S)-cyanovoacangine, and 10,11-demethoxychippiine were found to show appreciable cytotoxicity toward KB cells, while coronaridine, heyneanine, 19-epi-heyneanine, dippinine B, and dippinine C, were found to reverse MDR in vincristine-resistant KB cells.
Kam
Toh-Seok
TS
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. tskam@um.edu.my
Sim
Kooi-Mow
KM
Pang
Huey-Shen
HS
Koyano
Takashi
T
Hayashi
Masahiko
M
Komiyama
Kanki
K
D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000633:toxicity*; D026121:Indole Alkaloids / Q000633:toxicity*
D026121:Indole Alkaloids; D007050:Ibogaine