Molecularly imprinted polymers: a new tool for separation of steroid isomers.
Molecularly imprinted polymers hold great promise for the separation of chiral compounds. A non-covalent approach to the synthesis of MIPs relies on the presence of specific and non-specific interactions, which lead to the formation of a molecular imprint. The structural differences between 17-alpha-estradiol and 17-beta-estradiol are too small to permit their efficient separation on a MIP prepared with beta-estradiol as a template. Molecular modeling revealed the presence of only one hydrogen bond that differentiates the two isomers.
Szumski
Michał
M
Department of Environmental Chemistry and Ecoanalytics, Faculty of Chemistry, Nicolas Copernicus University, ul Gagarina 7, 87-100 Toruri, Poland.
Buszewski
Bogusław
B
D002845:Chromatography / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D004958:Estradiol / Q000032:analysis / Q000737:chemistry; D006860:Hydrogen Bonding; D008956:Models, Chemical; D008958:Models, Molecular; D011108:Polymers / Q000737:chemistry*; D020033:Protein Isoforms; D013256:Steroids / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification*; D013696:Temperature; D013997:Time Factors
D011108:Polymers; D020033:Protein Isoforms; D013256:Steroids; D004958:Estradiol