title: CDT values are not influenced by epithelial cell apoptosis in chronic alcoholic patients-preliminary results.
abstract: Carbohydrate-deficient transferrin (CDT) has been well established as a marker for high alcohol consumption. As studies concerning the specificity of CDT in patients with liver disease have shown controversial outcomes, efforts to illuminate mechanisms leading to impaired CDT specificity in this patient group cannot yet be considered successful. Evidence of apoptosis as examined in 72 alcohol-dependent patients using serum contents of caspase-related M30 monoclonal antibody significantly correlated with aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase but did not influence CDT levels. These results suggest that impairment of CDT specificity is brought forth by derangement of hepatic metabolism rather than by acute hepatocellular damage.
authors.affiliation: Department of Psychiatry, Medical University of Vienna, Vienna, Austria.
authors.forename: Katrin
authors.initials: K
authors.lastname: Ramskogler
authors.forename: Markus
authors.initials: M
authors.lastname: Brunner
authors.forename: Ines
authors.initials: I
authors.lastname: Hertling
authors.forename: Alexander
authors.initials: A
authors.lastname: Dvorak
authors.forename: Nestor
authors.initials: N
authors.lastname: Kapusta
authors.forename: Claus
authors.initials: C
authors.lastname: Krenn
authors.forename: Bernhard
authors.initials: B
authors.lastname: Moser
authors.forename: Georg
authors.initials: G
authors.lastname: Roth
authors.forename: Otto Michael
authors.initials: OM
authors.lastname: Lesch
authors.forename: Hendrik Jan
authors.initials: HJ
authors.lastname: Ankersmit
authors.forename: Henriette
authors.initials: H
authors.lastname: Walter
mesh_terms: D000437:Alcoholism / Q000097:blood*; D017209:Apoptosis / Q000502:physiology*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism*
chemical_list: D014168:Transferrin; C056759:carbohydrate-deficient transferrin