title: Hearing loss with semicircular canal transection and Pseudomonas aeruginosa otitis media.
abstract: OBJECTIVE
  To determine if Pseudomonas aeruginosa (PA) otitis media (OM) increases the risk of sensorineural hearing loss (SNHL) with semicircular canal transection in the guinea pig model.
  
  
  METHODS
  PA was injected transtympanically into both middle ears of pigmented guinea pigs. Saline-injected animals served as controls. Two to 4 days after injection, one horizontal semicircular canal was transected and sealed. Hearing was tested using electrocochleography before and after transection.
  
  
  RESULTS
  PA-OM was induced in all PA-injected ears. Five days after semicircular canal transection, click-evoked thresholds were significantly elevated in ears with PA-OM (P = 0.00009) but not in saline-injected ears (P = 0.398).
  
  
  CONCLUSIONS
  Violation of the inner ear in the presence of PA-OM is associated with increased risk of SNHL in the guinea pig.
  
  
  CONCLUSIONS
  Factors unique to PA infection may be responsible for SNHL with labyrinthine injury in humans with chronic otitis media.
authors.affiliation: Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
authors.forename: Angela R
authors.initials: AR
authors.lastname: Prevatt
authors.forename: Jack D
authors.initials: JD
authors.lastname: Sedwick
authors.forename: Byron J
authors.initials: BJ
authors.lastname: Gajewski
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Antonelli
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D008297:Male; D010035:Otitis Media, Suppurative / Q000382:microbiology* / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D011552:Pseudomonas Infections / Q000601:surgery*; D012665:Semicircular Canals / Q000601:surgery*