title: Histopathologic confirmation of complete cancer-cell kill in excised specimens after renal cryotherapy.
abstract: We present the first case of complete documentation of total cancer ablation in a previously cryoablated human renal tumor. A 61-year-old patient with metachronous bilateral renal cell carcinoma was treated with open partial nephrectomy and subsequently laparoscopic cryoablation. His renal function deteriorated, prompting bilateral radical nephrectomy before renal transplantation. Detailed histopathologic examination of the specimen did not reveal any evidence of malignancy in two cryoablated sites 36 months (left kidney) and 19 months (right kidney) after the respective cryoablations.
authors.affiliation: Section of Laparoscopic and Minimally Invasive Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: Chia-Hsiang
authors.initials: CH
authors.lastname: Lin
authors.forename: Alireza
authors.initials: A
authors.lastname: Moinzadeh
authors.forename: Anup P
authors.initials: AP
authors.lastname: Ramani
authors.forename: Inderbir S
authors.initials: IS
authors.lastname: Gill
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery*; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery*; D003452:Cryosurgery; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation; D010535:Laparoscopy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000601:surgery*; D009392:Nephrectomy; D012074:Remission Induction; D018239:Seminoma / Q000628:therapy; D013736:Testicular Neoplasms / Q000628:therapy