title: Cell density and cortical thickness in Heschl's gyrus in schizophrenia, major depression and bipolar disorder.
abstract: There is evidence that the superior temporal gyrus and Heschl's gyrus within it are implicated in schizophrenia. We investigated neuronal and glial cell density and cortical thickness within Heschl's gyrus, using the optical disector to estimate cell density within cortical layers 3 and 5 in tissue derived postmortem from people with diagnoses of major depressive disorder, schizophrenia and bipolar disorder, compared with normal controls (n=15 per group). No significant difference in neuronal or glial cell density or in cortical thickness was observed between the groups; our findings therefore provide no support for the presence of cellular pathology within Heschl's gyrus in schizophrenia.
authors.affiliation: Beaumont Hospital, Dublin 9, Ireland. drcotter@rcsi.ie
authors.forename: David
authors.initials: D
authors.lastname: Cotter
authors.forename: Daniel
authors.initials: D
authors.lastname: Mackay
authors.forename: Sophia
authors.initials: S
authors.lastname: Frangou
authors.forename: Lance
authors.initials: L
authors.lastname: Hudson
authors.forename: Sabine
authors.initials: S
authors.lastname: Landau
mesh_terms: D001303:Auditory Cortex / Q000473:pathology*; D001714:Bipolar Disorder / Q000473:pathology*; D002452:Cell Count; D003866:Depressive Disorder / Q000473:pathology*; D006801:Humans; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology; D012559:Schizophrenia / Q000473:pathology*