title: Thy-1: more than a mouse pan-T cell marker.
abstract: Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation. However, a physiological ligand or counterreceptor for murine Thy-1 in the lymphoid compartment has not yet been identified. Thy-1 cross-linking, in the context of strong costimulatory signaling through CD28, results in an activating signal that can at least partially substitute for TCR signaling during mouse T cell activation. Remarkably, Thy-1 cross-linking also results in the potent costimulation of T cells activated through the TCR. This novel dual signaling capacity suggests a possible role for Thy-1 in the maintenance of T cell homeostasis in the absence of TCR triggering, as well as potentiating Ag-induced T cell responses.
authors.affiliation: Cellular Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. mhaeryfar@niaid.nih.gov
authors.forename: S M Mansour
authors.initials: SM
authors.lastname: Haeryfar
authors.forename: David W
authors.initials: DW
authors.lastname: Hoskin
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis; D002454:Cell Differentiation / Q000276:immunology; D017261:Glycosylphosphatidylinositols / Q000502:physiology; D021962:Membrane Microdomains / Q000737:chemistry / Q000276:immunology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018800:Thy-1 Antigens / Q000032:analysis* / Q000378:metabolism / Q000502:physiology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D017261:Glycosylphosphatidylinositols; D018800:Thy-1 Antigens