title: Chemical methods for peptide-oligonucleotide conjugate synthesis.
abstract: Methods of peptide-oligonucleotide conjugate synthesis are presented that may be useful in the study of cell targeting and delivery of oligonucleotides and their analogs. The first method involves total stepwise solid-phase synthesis on a single support. The second involves preparation of oligonucleotides containing 2'-aldehydes and subsequent chemoselective ligation with functionalized peptides to form hydrazine, oxime, or thiazolidine linkages.
authors.affiliation: Laboratory of Molecular Biology, MRC, Cambridge, UK.
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Stetsenko
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gait
mesh_terms: D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D010455:Peptides