[Study of an animal model of post-menopausal atherosclerosis in rabbit and observation of the effect of herbal formula of tonifying-kidney on it].
OBJECTIVE
To establish an animal model imitating post-menopausal atherosclerosis in rabbit and observe the effect of the herbal formula of tonifying-kidney on this animal model.


METHODS
The New Zealand rabbits were treated with ovariectomy, high cholesterol diet plus immune injury, and both of ovariectomy and high cholesterol diet plus immune injury respectively. The blood lipid level and the intima and media of the aorta were observed.


RESULTS
The rabbits treated with ovariectomy and high cholesterol diet plus immune injury changed markedly and had low level of estrogen, high levels of CHOL, TG and dysfunction of the arterial endothelium cells. however, the chinese herbal formula of tonifying-kidney could relieve these changes.


CONCLUSIONS
The New Zealand rabbits treated with both of ovariectomy and high cholesterol diet plus immune injury could result in the changes imitating post-menopausal atherosclerosis, and it could be improved by the treatment of herbal formula of tonifying-kidney, so we think that the changes of the animal model are related to the deficiency of the kidney in traditional Chinese medicine.
Wang
Wen-Jian
WJ
Institute of Chinese Integrative Medicine, FU DAN University, Shanghai 200040, China. wj6518@163.com
Fei
Zhen-Yu
ZY
Fu
Xiao-Dong
XD
Chen
Wei-Hua
WH
Ying
Jian
J
Tang
Feng
F
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy*; D008076:Cholesterol, HDL / Q000187:drug effects / Q000378:metabolism; D008078:Cholesterol, LDL / Q000187:drug effects / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004967:Estrogens / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D023421:Models, Animal; D017698:Postmenopause / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D011897:Random Allocation; D013739:Testosterone / Q000097:blood / Q000378:metabolism; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; D004967:Estrogens; D014280:Triglycerides; D013739:Testosterone