Chemical genomics in yeast.
Many drugs have unknown, controversial or multiple mechanisms of action. Four recent 'chemical genomic' studies, using genome-scale collections of yeast gene deletions that were either arrayed or barcoded, have presented complementary approaches to identifying gene-drug and pathway-drug interactions.
Brenner
Charles
C
Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA. charles.brenner@dartmouth.edu
D023281:Genomics / Q000379:methods*; D020543:Proteome / Q000187:drug effects* / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D020543:Proteome