Bidirectional promoters regulate the monoallelically expressed Ly49 NK receptors.
Members of the Ly49 gene family of natural killer (NK) cell receptors in mice are expressed in seemingly stochastic combinations such that each NK cell expresses a handful of family members. A transcriptional switch appears to establish this interesting pattern of expression.
Ensminger
Alexander W
AW
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Chess
Andrew
A
D000483:Alleles; D000818:Animals; D000950:Antigens, Ly / Q000378:metabolism*; D005786:Gene Expression Regulation; D007694:Killer Cells, Natural / Q000378:metabolism*; D037181:Lectins, C-Type; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic; D011971:Receptors, Immunologic / Q000378:metabolism*; D055630:Receptors, NK Cell Lectin-Like
D000950:Antigens, Ly; D037181:Lectins, C-Type; D011971:Receptors, Immunologic; D055630:Receptors, NK Cell Lectin-Like