Hypoglycemic activity of Bauhinia candicans in diabetic induced rabbits.
The effect of different fractions of methanolic extract of Bauhinia candicans leaves were investigated on experimentally-induced diabetic rabbits. The crude extracts (8 mg/kg) showed hypoglycemic activity along with a reduced urinary glucose excretion. Among the fractions, the highest activity was exhibited by the butanolic fraction (fraction III). Moreover, fraction III reduced plasma glucose level also in normal, as well as, glucose loaded rabbits. These results suggest that B. candicans increases the peripheral metabolism of glucose.
Fuentes
O
O
Laboratorio de Fisiología, Facultad de Ciencias, Universidad, del Bío-Bío, Campus Chillán, Avenida Andrés Bello s/n, PO Box 447, Chillán, Chile. ofuentes@ubiobio.cl
Arancibia-Avila
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P
Alarcón
J
J
D000496:Alloxan; D000818:Animals; D036481:Bauhinia; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy; D004195:Disease Models, Animal; D005260:Female; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D011817:Rabbits
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan