title: New nucleoside reverse transcriptase inhibitors for the treatment of HIV infections.
abstract: Several new nucleoside analogs are currently in development for the treatment of HIV-1 infections. Alovudine, amdoxovir, elvucitabine, Racivir, Reverset and SPD 754 are nucleoside reverse transcriptase inhibitors that were designed and selected in anticipation of having improved resistance, safety, compatibility and efficacy profiles. Clinical trials are demonstrating that some of these goals are being met, and that nucleoside analogs as a class of compounds remain fertile ground for finding valuable additions to current anti-retrovirus treatment regimens.
authors.affiliation: 1860 Montreal Road, Pharmasset Inc. Tucker, Georgia, USA. motto@pharmasset.com
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Otto
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003570:Cytidine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D015224:Dideoxynucleosides / Q000494:pharmacology / Q000627:therapeutic use; D004148:Dioxolanes / Q000494:pharmacology / Q000627:therapeutic use; D000068679:Emtricitabine / Q000031:analogs & derivatives; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D011684:Purine Nucleosides / Q000494:pharmacology / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D013872:Thionucleosides / Q000494:pharmacology / Q000627:therapeutic use; D016047:Zalcitabine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C120719:2'-deoxy-3'-oxa-thiocytidine; D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D004148:Dioxolanes; D011684:Purine Nucleosides; D018894:Reverse Transcriptase Inhibitors; D013872:Thionucleosides; D003841:Deoxycytidine; C098393:amdoxovir; D003570:Cytidine Triphosphate; D016047:Zalcitabine; D000068679:Emtricitabine; C099405:dexelvucitabine; C002854:alovudine; C075889:Racivir