Murine thrombosis models.
Due to exciting advances in molecular biology, the laboratory mouse has become an important and frequently used model for studying thrombosis. This article reviews several experimental approaches that have been used to study arterial, venous, and microvascular thrombosis in mice. The advantages and limitations of different models are examined. Related topics of mouse anesthesia, phlebotomy, and in vitro hemostasis testing are also reviewed.
Day
Sharlene M
SM
Department of Internal Medicine, University of Michigan Medical Center, 7301 MSRB III, 1150 W. Medical Center Drive, Ann Arbor, Michigan 48109-0644, USA.
Reeve
Jennifer L
JL
Myers
Daniel D
DD
Fay
William P
WP
D000758:Anesthesia; D000818:Animals; D001800:Blood Specimen Collection; D001808:Blood Vessels / Q000293:injuries; D004195:Disease Models, Animal; D008722:Methods; D051379:Mice; D013927:Thrombosis / Q000209:etiology / Q000473:pathology / Q000628:therapy