Core-shell-type resins for solid-phase peptide synthesis: comparison with gel-type resins in solid-phase photolytic cleavage reaction.
[reaction: see text] Novel core-shell-type resins with a rigid core and amino-functionalized flexible shell were prepared with 2,4,6-trichloro-1,3,5-triazine (CNC) and Jeffamine ED-600 starting from 1% cross-linked aminomethyl (AM) polystyrene resins. All of the amino groups were located outside the resin beads, and the loading capacity was 0.2-0.4 mmol/g. The amount of CNC treated was a determining factor in the properties of the final resins. The core-shell-type resins showed superior performances in terms of the initial loading of amino acid and the photocleavage reaction compared to the gel-type resins.
Kim
Hanyoung
H
School of Chemical Engineering, Seoul National University, Seoul 151-744, Korea.
Cho
Jin Ku
JK
Chung
Woo-Jae
WJ
Lee
Yoon-Sik
YS
D002384:Catalysis; D005782:Gels / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*; D012117:Resins, Synthetic / Q000138:chemical synthesis* / Q000737:chemistry; D014227:Triazines / Q000737:chemistry
D005782:Gels; D010455:Peptides; D012117:Resins, Synthetic; D014227:Triazines