Comparative study on the chiral separation of phenyl alcohols by capillary electrophoresis and liquid chromatography.
Structurally related phenyl alcohols were separated by capillary electrophoresis and liquid chromatography. A statistical experimental design was used in order to optimize the main electrophoretic parameters such as pH, concentration of selector and separation voltage in capillary electrophoresis (CE). Response surfaces were derived using the mathematical model and used for a selection of the optimal experimental conditions. Concentration of the chiral selector, the distance between the aromatic group and asymmetric center of the analytes, were identified as the factors influencing the complexation, selectivity and resolution. Experiments were also performed by high-performance liquid chromatography (HPLC) and the results of CE and HPLC were compared.
Zhang
Yu-Ping
YP
Department of Chemistry, Graduate School, Kyungpook National University, Daegu, South Korea.
Lee
Kwang-Pill
KP
Kim
Sang-Ho
SH
Choi
Seong-Ho
SH
Gopalan
Anantha I
AI
Yuan
Zhuo-Bin
ZB
D001592:Benzyl Alcohols / Q000737:chemistry* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D015394:Molecular Structure; D013237:Stereoisomerism
D001592:Benzyl Alcohols