title: [Long-Term Therapy With Indirect Anticoagulants in Patients With Nonvalvular Atrial Fibrillation (Prospective Follow-Up Study). Part II. Effectiveness and Safety].
abstract: OBJECTIVE
  To assess efficacy and safety of long-term international normalized ratio (INR) guided therapy with acenocoumarol in patients with nonvalvular atrial fibrillation.
  
  
  METHODS
  Patients (n=100) with nonvalvular atrial fibrillation and at least 1 risk factor of thromboembolic complications.
  
  
  METHODS
  Ischemic strokes, episodes of systemic thromboembolism and hemorrhagic complications were registered during 3 years of treatment with acenocoumarol (target INR 2.0-3.0).
  
  
  RESULTS
  Annual rates of ischemic strokes, hemorrhagic complications and major bleeding were 0.7, 14.4 and 1.1%, respectively. No episodes of thromboembolism were registered in patients with history of thromboembolic complications. Basing on data collected predictors of bleeding complications in patients with atrial fibrillation during long term treatment with acenocoumarol were elucidated.
authors.affiliation: Cardiology Research Complex; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Kropacheva
authors.forename: E P
authors.initials: EP
authors.lastname: Panchenko
authors.forename: A B
authors.initials: AB
authors.lastname: Dobrovol'skiĭ
authors.forename: D M
authors.initials: DM
authors.lastname: Ataullakhanova
authors.forename: E S
authors.initials: ES
authors.lastname: Bykova
authors.forename: E V
authors.initials: EV
authors.lastname: Titaeva
authors.forename: O Iu
authors.initials: OIu
authors.lastname: At'kov
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001281:Atrial Fibrillation; D005500:Follow-Up Studies; D006801:Humans; D011446:Prospective Studies; D014859:Warfarin
chemical_list: D000925:Anticoagulants; D014859:Warfarin