title: [Synthesis and antitumour activities of some pteridine derivatives].
abstract: OBJECTIVE
  To study the synthesis and antitumour activities of some aryl-substituted pteridines.
  
  
  METHODS
  A series of aryl-substituted pteridines were synthesized from 4, 6-diamino-5-nitrosopyrimidines by cyclization with 4-aminophenylacetonitriles. The antitumour activities were tested by MTT method.
  
  
  RESULTS
  Nine new compounds (I-III) were synthesized and their structures were characterized by EA, IR, 1HNMR and MS spectra. Compounds I-III showed antitumour activities in vitro.
  
  
  CONCLUSIONS
  Compounds I-III showed remarkable antitumour activities in vitro. No interaction was determined between the title compounds and calf thymus DNA. It indicated that these compounds possibly inhibit dihydrofolate reductase (DHFR) or other enzymes on which folic acid depends.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou 510080, China.
authors.forename: Ji-wu
authors.initials: JW
authors.lastname: Ruan
authors.forename: Jin-feng
authors.initials: JF
authors.lastname: Huang
authors.forename: Li-wu
authors.initials: LW
authors.lastname: Fu
authors.forename: Zhi-shu
authors.initials: ZS
authors.lastname: Huang
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.forename: Lian-quan
authors.initials: LQ
authors.lastname: Gu
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D008175:Lung Neoplasms / Q000473:pathology; D015394:Molecular Structure; D011621:Pteridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011621:Pteridines