Genes encoding subunits of stable complexes are clustered on the yeast chromosomes: an interpretation from a dosage balance perspective.
Genomic evidence for colocalization of functionally related genes on eukaryote chromosomes is mounting. Here we show that a statistically significant fraction of yeast genes coding for subunits of stable complexes are located within 10-30 kb of each other. Clustering of genes encoding subunits of complexes may ensure better coregulation and maintain the right stoichiometry of complexes upon duplication of chromosomal segments.
Teichmann
Sarah Amalia
SA
MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, England.
Veitia
Reiner Albert
RA
D015825:Chromosomes, Fungal / Q000235:genetics; D018628:Gene Dosage; D005800:Genes, Fungal; D005810:Multigene Family; D021122:Protein Subunits / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*
D021122:Protein Subunits; D029701:Saccharomyces cerevisiae Proteins