title: Transcranial magnetic stimulation in patients with transient ischemic attacks.
abstract: BACKGROUND
  By definition, transient ischemic attacks (TIAs) do not leave a neurological deficit beyond 24 hours after onset. However, a subgroup of TIA patients is characterized by persistent perfusion defect on single photon emission computed tomogram or infarction on brain computerized tomogram and magnetic resonance imaging. Here, we applied transcranial magnetic stimulation (TMS) to study whether TIA could produce persistent subclinical dysfunction for more than 24 hours.
  
  
  METHODS
  The study included 23 TIA patients who had the criteria of hand weakness as one of their clinical manifestations. TMS was done twice in each TIA patient. The first time was during the period of 24-48 hours after onset and the second 7 days after onset. We studied the cortical motor threshold, the latencies and the amplitudes of the motor evoked potentials, the central motor conduction time, and the cortical silent period at the intensity of 1.5 times motor threshold with maximal voluntary isometric contraction. The recording was at the first dorsal interosseous muscle.
  
  
  RESULTS
  There was no significant difference between the whole group of TIA patients and normal control. However, in the subgroup of TIA patients who had hand weakness more than 1 hour, they had increased motor threshold and prolonged cortical silent period during the first test. Both improved 1 week after onset. On the contrary, in TIA patients who had hand weakness less than 1 hour, their data were all within normal limits during the first and the second studies.
  
  
  CONCLUSIONS
  Our results indicate that the motor function of TMS study will recover to full if the motor symptoms subside within 1 hour in TIA patients. Subclinical motor deficits may persist in TIA patients who have motor symptoms more than 1 hour.
authors.affiliation: Neurological Institute, Taipei Veterans General Hospital, Taiwan, ROC.
authors.forename: Wen-Jang
authors.initials: WJ
authors.lastname: Wong
authors.forename: Jen-Tse
authors.initials: JT
authors.lastname: Chen
authors.forename: Chuen-Der
authors.initials: CD
authors.lastname: Kao
authors.forename: Din-E
authors.initials: DE
authors.lastname: Shan
authors.forename: Yung-Yang
authors.initials: YY
authors.lastname: Lin
authors.forename: Han-Hwa
authors.initials: HH
authors.lastname: Hu
authors.forename: Zin-An
authors.initials: ZA
authors.lastname: Wu
authors.forename: Kwong-Kum
authors.initials: KK
authors.lastname: Liao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000503:physiopathology; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D013997:Time Factors