Mesalazine-induced reversible infertility in a young male.
Mesalazine is a well-established treatment for ulcerative colitis. A young man treated with mesalazine for proctitis was found to have pathological semen with a count of only 3 x 10(6) sperm cells/ml. He failed to achieve conception with his wife. When mesalazine treatment was stopped, semen analysis returned to near normal and pregnancy ensued. Due to recurrent disease activity, mesalazine treatment was reinstituted. This was followed by deterioration of the patient's semen.
Chermesh
I
I
Department of Gastroenterology Rambam Medical Centre and the Technion Faculty of Medicine, Bat Galim, RPO.B. 9602, Haifa 31096, Israel.
Eliakim
R
R
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D011350:Proctocolitis / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine