A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction.
Combined regioselective acylation/Michael addition reaction catalyzed by alkaline protease from Bacillus subtilis in anhydrous pyridine for synthesis of N-substituted imidazole derivatives containing a glucose branch via a novel single-enzyme, two-step, one-pot procedure is reported.
Yao
Shi-Ping
SP
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China. ysp20042001@yahoo.com.cn
Lu
De-Shui
DS
Wu
Qi
Q
Cai
Ying
Y
Xu
Shan-Hao
SH
Lin
Xian-Fu
XF
D000215:Acylation; D001412:Bacillus subtilis / Q000201:enzymology; D001426:Bacterial Proteins / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D010450:Endopeptidases / Q000737:chemistry / Q000494:pharmacology; D005947:Glucose / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis*; D008956:Models, Chemical; D011725:Pyridines / Q000737:chemistry; D013237:Stereoisomerism
D001426:Bacterial Proteins; D007093:Imidazoles; D011725:Pyridines; D010450:Endopeptidases; C087822:alkaline protease; D005947:Glucose