Colonic ischemia associated with naratriptan use.
A 54-year-old woman with acute onset of hematochezia and lower abdominal pain proved to have ischemic colitis associated with the use of naratriptan. The diagnosis was established by colonoscopy with biopsy. There were no other obvious risk factors for intestinal ischemia. The condition resolved within 4 days. Because the use of triptans for the treatment of migraine is increasing, health care providers should be aware of their potential for inducing ischemic colitis.
Schwartz
Darren C
DC
Department of Internal Medicine, Section of Gastroenterology & Hepatology, University of Wisconsin Medical School, Madison, Wisconsin, USA. dcs@medicine.wisc.edu
Smith
Daniel J
DJ
D015746:Abdominal Pain / Q000139:chemically induced; D003106:Colon / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D003108:Colonic Diseases / Q000209:etiology*; D005260:Female; D006261:Headache / Q000188:drug therapy; D006801:Humans; D007211:Indoles / Q000009:adverse effects* / Q000627:therapeutic use; D007511:Ischemia / Q000139:chemically induced*; D008875:Middle Aged; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000627:therapeutic use; D014363:Tryptamines
D007211:Indoles; D010880:Piperidines; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C106783:naratriptan