Determination of lansoprazole in pharmaceutical capsules by flow injection analysis using UV-detection.
The direct determination of lansoprazole by using a flow injection analysis (FIA) with UV-detection and its application to the pharmaceutical capsules is described, in this study. The best carrier solvent was found to be 0.01 M NaOH and it was determined at optimum conditions such as flow rate of 1 ml min(-1) and wavelength of 292 nm. Examining the repeatability of the method that was found to be 1.72% for intra-day and 2.13% for inter-day precision using the 8.01 x 10(-6) M lansoprazole concentration has validated the method. The linear range of the method was 5.4 x 10(-6) to 5.4 x 10(-5) M. The limit of detection and quantification was found to be 5.8 x 10(-7) and 1.7 x 10(-6) M, respectively. The proposed method was applied to the pharmaceutical capsules and very good results obtained. Thus, the FIA method for the quantification of lansoprazole can be proposed as a cheap, rapid, easy, accurate, and precise method for the routine determination in pharmaceutical preparations.
Yeniceli
Duygu
D
Department of Analytical Chemistry, Faculty of Pharmacy, University of Anadolu, 26470 Eskisehir, Turkey.
Dogrukol-Ak
Dilek
D
Tuncel
Muzaffer
M
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D002214:Capsules; D017022:Flow Injection Analysis; D064747:Lansoprazole; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000032:analysis* / Q000592:standards; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000592:standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D002214:Capsules; D004364:Pharmaceutical Preparations; D064747:Lansoprazole; D009853:Omeprazole