Effect of lupeol isolated from Crataeva nurvala Buch.-Ham. stem bark extract against free radical induced nephrotoxicity in rats.
Lupeol, isolated from Crataeva nurvala stem bark in doses 40 and 80 mg/kg body weight, po, for 10 days, decreased the concentration of blood urea nitrogen, creatinine and lipid peroxidation and increased glutathione and catalase activities in cisplatin (5 mg/kg body weight, ip) induced nephrotoxicity in rats. The increased glutathione and catalase activities are indicative of antioxidant properties of lupeol.
Shirwaikar
Annie
A
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576 104, India. annieshirwaiker@yahoo.com
Setty
Manjunath
M
Bommu
Praveen
P
D000818:Animals; D002945:Cisplatin / Q000633:toxicity; D005609:Free Radicals; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D000094042:Lupanes
D002945:Cisplatin; D005609:Free Radicals; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes