title: Clinical experience of transjugular intrahepatic portosystemic shunt (TIPS) and its effects on systemic hemodynamics.
abstract: We performed TIPS (transjugular intrahepatic portosystemic shunt) in patients with intractable esophageal varices accompanied by repeated hematemesis or with refractory ascites for the purpose of portal venous decompression, and successfully obtained complete elimination of esophageal varices or a marked decrease in ascites. While TIPS caused no particular variations in mean blood pressure or heart rate, cardiac output increased markedly on the 2nd and 3rd postoperative days before declining on the 5th postoperative day. Along with this, right atrial pressure, pulmonary arterial pressure and pulmonary capillary wedge pressure also increased transiently. TIPS has the potential to become an established effectual therapy for intractable esophageal varices and refractory ascites. However, careful attention should be paid to its hemodynamic effects, including the occurrence of cardiac failure.
authors.affiliation: Department of Surgery, Tokyo Women's Medical University Daini Hospital, Japan. narisu@dnh.twmu.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Naritaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Ogawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimakawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Wagatsuma
authors.forename: Soichi
authors.initials: S
authors.lastname: Konno
authors.forename: Takao
authors.initials: T
authors.lastname: Katsube
authors.forename: Kanako
authors.initials: K
authors.lastname: Hamaguchi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Hosokawa
mesh_terms: D000368:Aged; D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D011183:Postoperative Complications / Q000503:physiopathology*; D012307:Risk Factors; D014057:Tomography, X-Ray Computed