title: Depressed host immunity in a case of metachronous primary uterine papillary serous carcinoma and non-Hodgkin's lymphoma.
abstract: Metachronous primary malignant tumors of uterine papillary serous carcinoma (UPSC) and non-Hodgkin's lymphoma (NHL) are rare. UPSC is a clinically aggressive and morphologically distinctive variant of endometrial carcinoma. We describe the clinical features of a 63-year-old patient with UPSC that was found 2 years after chemotherapy for malignant lymphoma of neck, stage IV and 5 months after radiation therapy for recurrence. This patient had undergone staging surgery and postoperative radiation for UPSC. One month after completion of radiotherapy, the patient expired due to persistence of the disease. The association between host immunity and UPSC is rarely described in the literature. Immunological profiles of this patient, with compositional changes of natural killer, B, and T cell, dramatically altered the percentage of CD4(+) T cell, CD8(+) T cell, and CD4/CD8 ratio, signifying depressed host immunity. Immunological profile of this patient stressed the issue of depressed host immunity and associated malignancies.
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: W-C
authors.initials: WC
authors.lastname: Chang
authors.forename: B-C
authors.initials: BC
authors.lastname: Sheu
authors.forename: R-C
authors.initials: RC
authors.lastname: Chen
authors.forename: S-N
authors.initials: SN
authors.lastname: Chow
authors.forename: S-C
authors.initials: SC
authors.lastname: Huang
mesh_terms: D002291:Carcinoma, Papillary / Q000276:immunology* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016867:Immunocompromised Host; D007694:Killer Cells, Natural; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000532:radiotherapy*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology*