title: Splenic lymphoma with villous lymphocytes, associated with type II cryoglobulinemia and HCV infection: a new entity?
abstract: Hepatitis C virus (HCV) has been associated with the development of B-cell non-Hodgkin lymphomas. We recently reported the regression of splenic lymphoma with villous lymphocytes (SLVL) in patients with HCV after antiviral treatment, demonstrating a direct role of HCV in lymphomagenesis. This study expands our previous results in 18 patients with chronic HCV and SLVL. Mixed cryoglobulinemia (MC) was present in all cases and was symptomatic in 13 (72%). All patients were treated with interferon alone or in association with ribavirin. Hematologic and virologic responses were correlated. Fourteen (78%) patients achieved a sustained complete hematologic response after clearance of HCV RNA. Two patients had a virologic partial response and achieved a complete hematologic response. Two virologic nonresponders achieved partial hematologic response. Regardless of the response, monoclonal immunoglobulin gene rearrangement persisted after treatment. This study underscores the role of HCV in the lymphomagenesis and the benefit of antiviral treatment for patients presenting with HCV-driven lymphoproliferations.
authors.affiliation: Department of Hematology, Hôpital Necker, Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: Saadoun
authors.forename: Felipe
authors.initials: F
authors.lastname: Suarez
authors.forename: François
authors.initials: F
authors.lastname: Lefrere
authors.forename: Françoise
authors.initials: F
authors.lastname: Valensi
authors.forename: Xavier
authors.initials: X
authors.lastname: Mariette
authors.forename: Achille
authors.initials: A
authors.lastname: Aouba
authors.forename: Caroline
authors.initials: C
authors.lastname: Besson
authors.forename: Bruno
authors.initials: B
authors.lastname: Varet
authors.forename: Xavier
authors.initials: X
authors.lastname: Troussard
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
authors.forename: Oliver
authors.initials: O
authors.lastname: Hermine
mesh_terms: D003449:Cryoglobulinemia / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008223:Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D016896:Treatment Outcome