title: Latex allergy and skin.
abstract: OBJECTIVE
  In this review we address the prevalence and outcome of latex allergy in health care workers (HCWs). Recent findings in natural rubber latex (NRL) allergens and trials of specific immunotherapy (SIT) are also of interest.
  
  
  RESULTS
  A study involving skin prick test (SPT) screening in HCWs in Russia and adjacent countries found a prevalence of latex allergy of 1.9%. Questionnaire studies performed in Wales and in the USA identified prevalence rates of about 0.6%. An intervention undertaken at the Mayo Clinic, in which only gloves with low or undetectable allergen levels were allowed, reduced markedly the incidence of NRL allergy. Two studies, one from Finland and another from Ohio, showed that outcomes in latex-allergic HCWs are generally good. A study involving SPT screening showed that 6% of construction workers had latex allergy. A questionnaire study among allergists practicing in the USA showed that 62% performed latex SPT and 6% reported anaphylaxis, which mostly occurred while using a homemade SPT solution. Hev b 2, Hev b 5, Hev b 6.01 and Hev b 13 produced positive SPT reactions in over 60% of latex-allergic individuals. Topical application of NRL in a murine model of protein contact dermatitis caused a striking increase in prohevein-specific (Hev b 6.01) immunoglobulin E levels, together with a T-helper-2 type dermatitis. A placebo-controlled SIT trial with NRL extract alleviated cutaneous symptoms but caused some systemic reactions in latex-allergic patients.
  
  
  CONCLUSIONS
  Low prevalence rates suggest that the peak of the latex allergy epidemic has already passed in HCWs. Hospital-wide interventions requiring use of low-allergen gloves reduce sensitization and changing gloves to nonlatex ones, or even using low-allergen latex gloves, in the affected individuals appears to confer adequate secondary prevention. In the USA there is an urgent need for standardized latex SPT reagent. Hev b 5 and Hev b 6.01 are major in vivo NRL allergens. Findings in mice suggest that NRL proteins eluting from latex gloves may also cause hand eczema in humans. SIT with NRL extract must still be considered an experimental treatment.
authors.affiliation: Department of Dermatology, University and University Hospital of Tampere, Tampere, Finland. timo.reunala@uta.fi
authors.forename: Timo
authors.initials: T
authors.lastname: Reunala
authors.forename: Harri
authors.initials: H
authors.lastname: Alenius
authors.forename: Kristiina
authors.initials: K
authors.lastname: Turjanmaa
authors.forename: Timo
authors.initials: T
authors.lastname: Palosuo
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D002648:Child; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D006282:Health Personnel; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology / Q000627:therapeutic use; D007167:Immunotherapy; D007840:Latex / Q000276:immunology*; D020315:Latex Hypersensitivity / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000628:therapy; D051379:Mice; D023421:Models, Animal; D017063:Outcome Assessment, Health Care; D015995:Prevalence
chemical_list: D000485:Allergens; D007840:Latex; D007073:Immunoglobulin E