[Study on blood ABO typing in patients with autoimmune hemolytic anemia].
To explore effect of autoantibody on identification of ABO and RhD blood group, the blood samples of 38 patients with autoimmune hemolytic anemia (AIHA) were identified by routine typing and typing after chloroquine elution test as well as PCR. The results showed that out of 38 patients with AIHA, 11 cases (31.6%) of ABO blood group were difficulty typed, indirect antiglobulin test were positive, and contradiction between cells typing and sera typing were observed. 1 case of RhD(-) was mistyped as RhD(+) and anti-D was found in its serum. The blood group of these cases were typed correctly by chloroquine elution test. It is concluded that blood group identification of patients with AIHA can be interfered by autoantibody, and the correct typing for blood group of these patients may be determined by using combination of several methods to ensure safe transfusion.
Zhu
Jian-Ying
JY
Shaoguan Blood Center, Shaoguan 512026, China.
Lan
Jiong-Cai
JC
Hu
Li-Ya
LY
Meng
Qing-Bao
QB
Luo
Hong-Qing
HQ
D000017:ABO Blood-Group System / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood*; D001788:Blood Grouping and Crossmatching; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System