title: An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population.
abstract: We performed an association study between three SNPs in the genes of 14-3-3 family and paranoid schizophrenia. SNP rs983583 G/A in the YWHAZ gene showed significant association with paranoid schizophrenia. Our study indicated that the YWHAZ gene was a potential susceptibility gene for paranoid schizophrenia in the population studied.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Jia
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.forename: Boyu
authors.initials: B
authors.lastname: Zhang
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Yuan
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Yucun
authors.initials: Y
authors.lastname: Shen
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000328:Adult; D002681:China; D017931:DNA Primers / Q000235:genetics; D004789:Enzyme Activation; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009483:Neuropsychological Tests; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
chemical_list: D017931:DNA Primers; D006899:Mixed Function Oxygenases; C023204:tryptophan 2-monooxygenase; D014446:Tyrosine 3-Monooxygenase