[Applied study on small-dose growth hormone supplement for aging-related symptom complex].
OBJECTIVE
To assess the response of aging-related symptom complex to small-dose supplement of growth hormone.


METHODS
Thirty patients, aged 42 to 77, with aging-related symptom complex and normal serum testosterone were studied. Each subject received growth hormone at the dosage of 0.04 U/kg, 3 times/week for six months. Before and after treatment, body weight, grip strength, abdomen circumference, IPSS, uroflow rate, prostate volume, serum testosterone, cholesterol, triglyceride, PSA, IGF-1, glucose and side effects were determined in every case. Self Rating Scale used by Bosphorus university was adopted.


RESULTS
After the treatment, the rating scores were significantly improved, grip strength and serum level of IGF-1 increased, and abdomen circumference and serum cholesterol decreased. Whereas, IPSS, uroflow rate, prostate volume, serum testosterone, triglyceride, PSA, glucose and body weight were not significantly changed.


CONCLUSIONS
Six months treatment with small-dose growth hormone can improve aging-related symptom complex with little adverse effect.
Zhang
Xiansheng
X
Department of Urology, Affiliated Renji Hospital of Shanghai Second Medical University, Shanghai Institute of Andrology, Shanghai 200001, China. xiansheng-zhang@163.com
Wang
Yixin
Y
Li
Zheng
Z
Leng
Jing
J
Bai
Qiang
Q
Huang
Xuyuan
X
Huang
Yiran
Y
D000328:Adult; D000368:Aged; D019588:Aging, Premature / Q000188:drug therapy*; D047649:Andropause; D001786:Blood Glucose / Q000378:metabolism; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood
D001786:Blood Glucose; D008055:Lipids; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D017430:Prostate-Specific Antigen