title: Eyelid bleeding and atypical amyloidosis.
abstract: OBJECTIVE
  To describe a case of atypical systemic amyloidosis in a patient who presented with recurrent subcutaneous bleeding of the eyelids and auricles.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A 52-year-old man with chronic cardiac failure, hypertension, weight loss, and impotence presented with recurrent bleeding of the eyelids and auricles, and was investigated for suspected amyloidosis.
  
  
  RESULTS
  Biopsy specimens taken from the bone marrow, salivary gland, abdominal subcutaneous fat, and gastric mucosa, and eyelids were all negative for Congo red. Results of a conjunctival biopsy, which were returned after the patient's death, and cardiac muscle autopsy were positive for Congo red staining, indicating amyloidosis.
  
  
  CONCLUSIONS
  The findings in this case show that the presentation of amyloidosis may be atypical. Ophthalmologists should consider a diagnosis of amyloidosis in patients with periorbital bleeding, even if biopsies are negative for Congo red. A conjunctival biopsy may be useful in establishing a diagnosis of primary systemic amyloidosis.
authors.affiliation: Department of Ophthalmology, Kaplan Medical Center, Rehovot 76100, Israel. genal@inter.net.il
authors.forename: Gennady
authors.initials: G
authors.lastname: Landa
authors.forename: Eyal
authors.initials: E
authors.lastname: Aloni
authors.forename: Asher
authors.initials: A
authors.lastname: Milshtein
authors.forename: Arie
authors.initials: A
authors.lastname: Marcovich
authors.forename: Marta
authors.initials: M
authors.lastname: Mozes
authors.forename: Ayala
authors.initials: A
authors.lastname: Pollack
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis*; D005130:Eye Hemorrhage / Q000175:diagnosis*; D005141:Eyelid Diseases / Q000175:diagnosis*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged