title: In vitro susceptibilities of isolates of Sporothrix schenckii to itraconazole and terbinafine.
abstract: Thirty isolates of the yeast form of Sporothrix schenckii were evaluated for in vitro susceptibility to itraconazole and terbinafine by the recommended NCCLS modified technique (M27-A2). The MICs of itraconazole obtained oscillated between 0.062 and 4.0 microg/ml, and those of terbinafine oscillated between 0.007 and 0.50 microg/ml; therefore, terbinafine showed greater in vitro activity.
authors.affiliation: Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Lidiane Meire
authors.initials: LM
authors.lastname: Kohler
authors.forename: Paulo César Fialho
authors.initials: PC
authors.lastname: Monteiro
authors.forename: Rosane Christine
authors.initials: RC
authors.lastname: Hahn
authors.forename: Júnia Soares
authors.initials: JS
authors.lastname: Hamdan
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002415:Cats; D006736:Horses; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology*; D013175:Sporothrix / Q000187:drug effects* / Q000302:isolation & purification; D013174:Sporotrichosis / Q000175:diagnosis / Q000662:veterinary; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D000077291:Terbinafine