title: Opacification of hydrophilic MemoryLens U940A intraocular lenses: analysis of 2 explanted lenses.
abstract: OBJECTIVE
  To determine the rate of opacification of hydrophilic MemoryLens U940A intraocular lenses (IOLs) (Mentor Ophthalmics, Inc.) in the given cohort and perform a histopathological and spectrophotometer analysis of 2 explanted opacified IOLs.
  
  
  METHODS
  Ophthalmology Department, Faculty Hospital, Nitra, Slovakia.
  
  
  METHODS
  This retrospective study comprised 182 patients (205 eyes) who had implantation of a MemoryLens U940A IOL from June 1997 to June 2000. The patients were examined using a slitlamp to detect the presence of IOL opacification. In 4 cases, the lenses were explanted because of significant opacification and patient-reported problems; 2 lenses were provided for further analysis. One unused reference MemoryLens U940A IOL was also evaluated. All IOL were stained with von Kossa to determine the presence of calcium in the opacification. To confirm the components presence of an ultraviolet (UV) absorber, the IOLs were examined with an Avatar 330 Fourier transfer infrared (IR) spectroscope and a UV visible spectrophotometer (Philips). The IR spectrums for the IOL were identified using an IR spectrum atlas. The opacified IOLs, reference IOL, and the IOL packaging were further examined to determine the presence of silicone.
  
  
  RESULTS
  Various amounts of opacification were found on the MemoryLens U940A IOL in 30 eyes (30 patients) (14.63%). Two explanted IOLs were positive for von Kossa staining, proving the presence of calcium deposits; the reference lens staining was negative. Spectrophotometry showed that the reference IOL and opacified IOLs were of the same polymer. The presence of the UV absorber on the benzophenone base was seen in the reference lens but not the opacified IOLs. In contrast, an increased concentration of low-molecular-weight components generated during the degradation of the polymer was present in the opacified lenses. The white cover pf the IOL is of polydimethyl siloxane, a silicone rubber. However, no silicone rubber was present in any examined lens, perhaps because the IOLs were in contact with alcohol during the histopathologic examination.
  
  
  CONCLUSIONS
  The results indicate opacification of the hydrophilic MemoryLens U940A was caused by premature consumption of the UV absorber in the polymer component of the IOLs optic, with a subsequent degradation of the polymer. Whether silicone from the white cover led to the IOL opacification, as reported with other types of hydrophilic IOLs, could not be confirmed.
authors.affiliation: Ophthalmology Department, Faculty Hospital in Nitra, Nitra, Slovakia. janamatta@hotmail.com
authors.forename: Jana
authors.initials: J
authors.lastname: Mattová
authors.forename: Eulália
authors.initials: E
authors.lastname: Bohácová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Murgasová
authors.forename: Róbert
authors.initials: R
authors.lastname: Kadlec
authors.forename: Frantisek
authors.initials: F
authors.lastname: Forgác
authors.forename: Erika
authors.initials: E
authors.lastname: Klobusická
authors.forename: Dusan
authors.initials: D
authors.lastname: Durcanský
mesh_terms: D000368:Aged; D001672:Biocompatible Materials / Q000737:chemistry*; D002118:Calcium / Q000032:analysis; D020878:Device Removal; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D018918:Phacoemulsification; D011475:Prosthesis Failure; D012189:Retrospective Studies; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D002118:Calcium