[Role of proteins of the macroglobulin family in the mechanisms of infection].
Information on the properties of proteins of the macroglobulin family taking part in the host protection from viral, fungal and bacterial pathogens is reviewed. High plasticity and polyfunctional character of these proteins makes it possible to realize different protective functions. They inhibit the lysis of the cell wall by binding the hydrolases of the pathogen thus blocking its penetration into the cell, directly participate in the presentation of antigens to immunocompetent cells, transport antibacterial substances (interferons, lysozyme) to the zone of infection. In addition, macroglobulins take part in the apoptosis regulation in infected cells, utilization of the lysosomal enzymes of annihilated pathogens. The complexes of macroglobulins with some proteins are powerful inductors of antibody production. Further studies of the properties of these proteins will result in a better understanding of the nature of infectious process. The possibility of artificial formation of macroglobulin complexes with pathogen components or with substances possessing protective or anti-inflammatory properties opens prospects for using these proteins in the fields of vaccinology, gene therapy and molecular biology.
Zorin
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Zorina
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VN
D000818:Animals; D000906:Antibodies / Q000276:immunology; D017951:Antigen Presentation; D017209:Apoptosis; D001424:Bacterial Infections / Q000276:immunology*; D001692:Biological Transport; D006801:Humans; D006867:Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism; D007109:Immunity / Q000502:physiology; D007372:Interferons / Q000378:metabolism; D009113:Muramidase / Q000378:metabolism; D009181:Mycoses / Q000276:immunology*; D011266:Pregnancy-Associated Plasma Protein-A / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D014777:Virus Diseases / Q000276:immunology*; D000511:alpha-Macroglobulins / Q000276:immunology / Q000378:metabolism / Q000502:physiology*
D000906:Antibodies; D000511:alpha-Macroglobulins; D007372:Interferons; D006867:Hydrolases; D009113:Muramidase; D011266:Pregnancy-Associated Plasma Protein-A