Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa.
A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.
Nakao
Yoichi
Y
Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822-2275, USA. ayocha@mail.ecc.u-tokyo.ac.jp
Yoshida
Wesley Y
WY
Takada
Yuuki
Y
Kimura
Junji
J
Yang
Liu
L
Mooberry
Susan L
SL
Scheuer
Paul J
PJ
D000818:Animals; D000970:Antineoplastic Agents; D004354:Drug Screening Assays, Antitumor; D006254:Hawaii; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D008974:Mollusca; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C492405:kulokekahilide-2