TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression.
Life expectancy for patients suffering from prostate cancer is inversely correlated with the degree of extraprostatic metastasis. In order to find pharmacological tools to treat this aggressive growth it is important to define targets whose expression not only correlates with the malignancy of the cancerous cells, but that are also amenable to pharmacological intervention. In this review, we would like to focus on the potential role of a distinct class of ion channels that may be involved in this process.
Wissenbach
Ulrich
U
Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Universität des Saarlandes, D-66421 Homburg, Germany.
Niemeyer
Barbara
B
Himmerkus
Nina
N
Fixemer
Thomas
T
Bonkhoff
Helmut
H
Flockerzi
Veit
V
D015220:Calcium Channels / Q000378:metabolism* / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D050916:TRPV Cation Channels
D015220:Calcium Channels; D050916:TRPV Cation Channels; C120776:TRPV6 channel