The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1.
The plant cyclotides, the largest known family of circular proteins, have tightly folded structures and a range of biological activities that lend themselves to potential pharmaceutical and agricultural applications. Based on sequence homology, they are classified into the bracelet and Möbius subfamilies. The bracelet subfamily has previously been shown to display anti-HIV activity. We show here that a member of the Möbius subfamily, kalata B1, also exhibits anti-HIV activity despite extensive sequence differences between the subfamilies. In addition, acyclic permutants of kalata B1 displayed no anti-HIV activity, suggesting that this activity is critically dependent on an intact circular backbone.
Daly
Norelle L
NL
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
Gustafson
Kirk R
KR
Craik
David J
DJ
D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D047169:Cyclotides; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid
D019380:Anti-HIV Agents; D047169:Cyclotides; D010456:Peptides, Cyclic; C091930:kalata B1