title: YidC family members are involved in the membrane insertion, lateral integration, folding, and assembly of membrane proteins.
abstract: Members of the YidC family exist in all three domains of life, where they control the assembly of a large variety of membrane protein complexes that function as transporters, energy devices, or sensor proteins. Recent studies in bacteria have shown that YidC functions on its own as a membrane protein insertase independent of the Sec protein-conducting channel. YidC can also assist in the lateral integration and folding of membrane proteins that insert into the membrane via the Sec pathway.
authors.affiliation: Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA. dalbey@chemistry.ohio-state.edu
authors.forename: Ross E
authors.initials: RE
authors.lastname: Dalbey
authors.forename: Andreas
authors.initials: A
authors.lastname: Kuhn
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D017510:Protein Folding; D011498:Protein Precursors / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D011498:Protein Precursors