title: Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites.
abstract: Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened 252 primary MALT lymphomas for translocations t(11;18)(q21;q21), t(14;18)(q32;q21), and t(1;14)(p22;q32), and trisomies 3 and 18. The above-listed translocations occurred mutually exclusively and were detected overall in 13.5, 10.8, and 1.6% of the cases; trisomy 3 and/or 18 occurred in 42.1%. The frequency at which the translocations occurred varied markedly with the primary site of disease. The t(11;18)(q21;q21) was mainly detected in pulmonary and gastric tumors, whereas the t(14;18)(q32;q21) was most commonly found in lesions of the ocular adnexa/orbit, skin, and salivary glands. Trisomies 3 and 18 each occurred most frequently in intestinal and salivary gland MALT lymphomas. Our results demonstrate that the three translocations and trisomies 3 and 18 occur at markedly variable frequencies in MALT lymphoma of different sites.
authors.affiliation: Institute of Pathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Streubel
authors.forename: I
authors.initials: I
authors.lastname: Simonitsch-Klupp
authors.forename: L
authors.initials: L
authors.lastname: Müllauer
authors.forename: A
authors.initials: A
authors.lastname: Lamprecht
authors.forename: D
authors.initials: D
authors.lastname: Huber
authors.forename: R
authors.initials: R
authors.lastname: Siebert
authors.forename: M
authors.initials: M
authors.lastname: Stolte
authors.forename: F
authors.initials: F
authors.lastname: Trautinger
authors.forename: J
authors.initials: J
authors.lastname: Lukas
authors.forename: A
authors.initials: A
authors.lastname: Püspök
authors.forename: M
authors.initials: M
authors.lastname: Formanek
authors.forename: T
authors.initials: T
authors.lastname: Assanasen
authors.forename: H-K
authors.initials: HK
authors.lastname: Müller-Hermelink
authors.forename: L
authors.initials: L
authors.lastname: Cerroni
authors.forename: M
authors.initials: M
authors.lastname: Raderer
authors.forename: A
authors.initials: A
authors.lastname: Chott
mesh_terms: D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000145:classification / Q000235:genetics* / Q000473:pathology; D009928:Organ Specificity; D014178:Translocation, Genetic; D014314:Trisomy / Q000235:genetics*