Glucose hypometabolism of hypothalamus and thalamus in narcolepsy.
It has been hypothesized that hypothalamus is involved in narcolepsy. The relative difference between cerebral glucose metabolism of 24 narcoleptic patients and 24 normal controls was studied using 18F-fluorodeoxy glucose positron emission tomography. Patients with narcolepsy showed significantly reduced cerebral glucose metabolism in bilateral rectal and subcallosal gyri, the medial convexity of right superior frontal gyrus, bilateral precuneus, right inferior parietal lobule, and in left supramarginal gyrus (uncorrected p < 0.001). Bilateral posterior hypothalami and mediodorsal thalamic nuclei showed hypometabolism with significance at the level of corrected p < 0.05, with small volume correction. This study showed cerebral glucose hypometabolism of the hypothalamus-thalamus-orbitofrontal pathways in the narcoleptic brain.
Joo
Eun Yeon
EY
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Gangnam-Gu, Seoul, Korea.
Tae
Woo Suk
WS
Kim
Jee Hyun
JH
Kim
Byung Tae
BT
Hong
Seung Bong
SB
D000293:Adolescent; D000328:Adult; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000378:metabolism*; D016011:Normal Distribution; D017286:Polysomnography / Q000379:methods; D013788:Thalamus / Q000378:metabolism*; D014055:Tomography, Emission-Computed / Q000379:methods
D005947:Glucose