A novel reduction of diketones with i-RMgBr catalyzed by Cp2TiCl2 and deoxygenation of sulfoxides by Cp2TiCl2/Al system.
Alpha-diketones and beta-diketones react with Grignard reagents in the presence of a catalytic amount of Cp2TiCl2 to yield alpha-ketols and corresponding ketones respectively. Sulfoxides can be deoxygenated by Cp2TiCl2/Al system. The possible mechanisms are also discussed.
Zhang
Yong-min
YM
Department of Chemistry, Zhejiang University, Hangzhou 310028, China. yminzhang@mail.hz.zj.cn
Lin
Mao-qin
MQ
Yu
Yong-ping
YP
D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D017616:Magnesium Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D013454:Sulfoxides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D002712:Chlorides; D007202:Indicators and Reagents; D007659:Ketones; D017616:Magnesium Compounds; D013454:Sulfoxides; D014025:Titanium; D010100:Oxygen