title: Antibody, complement and accommodation in ABO-incompatible transplants.
abstract: Many facets of accommodation have been explored since this process was first observed in ABO-incompatible renal allografts over 17 years ago. Intriguing new pieces of the puzzle have emerged to be fitted into the picture in several places. For example, vascular endothelial cells can be stimulated to secrete substantial amounts of blood group A and B antigens linked to von Willebrand factor; the antibody response to A and B antigens stimulated by ABO-incompatible renal allografts can show epitope spreading; complement can inhibit inflammation through actions of some complement split products, particularly iC3b and C3a; endothelial cells can upregulate various cytoprotective mechanisms; and clinically, new protocols for achieving accommodation have been implemented with improved results.
authors.affiliation: Department of Pathology, Johns Hopkins Medical Institutes, 720 Rutland Avenue, Baltimore, Maryland 21205-2196, USA.
authors.forename: Karen E
authors.initials: KE
authors.lastname: King
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Warren
authors.forename: Milagros
authors.initials: M
authors.lastname: Samaniego-Picota
authors.forename: Sally
authors.initials: S
authors.lastname: Campbell-Lee
authors.forename: Robert A
authors.initials: RA
authors.lastname: Montgomery
authors.forename: William M
authors.initials: WM
authors.lastname: Baldwin
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology; D000222:Adaptation, Physiological / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology*; D042783:Endothelial Cells / Q000276:immunology*; D006801:Humans; D014184:Transplantation, Homologous / Q000276:immunology
chemical_list: D000017:ABO Blood-Group System; D000906:Antibodies; D003165:Complement System Proteins