[Study on the mechanism of traditional Chinese medicines in promoting gastrointestinal peristalsis].
Traditional Chinese medicine has accumulated rich experience in treating dysfunction of gastrointestinal peristalsis. In recent years, a large number of studies have been made on the mechanism and effects of traditional Chinese medicines on the gastrointestinal peristalsis, and the concept of "gastrointestinal promoting Chinese medicine" has been advocated. These traditional Chinese medicines can be divided into three types: promoting the gastrointestinal peristalsis, inhibiting the gastrointestinal peristalsis, and bi-directional modulating. The in vivo and/or in vitro experiments showed that some of the traditional Chinese medicines for activating blood or regulating qi could promote the stomach peristalsis, and the traditional Chinese medicines for moistening intestines to relieve constipation or invigorating spleen to promote digestion could accelerate the intestinal peristalsis. The mechanism lies in the neuroregulation and gut-peptide regulation. Further research on multi-regulation and of multi-target should be done, for the mechanism of the traditional Chinese medicines in regulating the gastrointestinal peristalsis is far more complicated.
Wei
Mu-Xin
MX
Department of Traditional Chinese Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province 210029, China. weimuxin@public1.ptt.js.cn
Wei
Lan-Fu
LF
Zhou
Bai-Cang
BC
Zhao
Guo-Ping
GP
D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D041981:Gastrointestinal Tract / Q000187:drug effects*; D006801:Humans; D008516:Medicine, Chinese Traditional; D010528:Peristalsis / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts