title: The knockout mouse project.
abstract: Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA. austinc@mail.nih.gov
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Austin
authors.forename: James F
authors.initials: JF
authors.lastname: Battey
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authors.lastname: Bradley
authors.forename: Maja
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authors.lastname: Bucan
authors.forename: Mario
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authors.lastname: Capecchi
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authors.lastname: Collins
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authors.lastname: Duyk
authors.forename: Susan
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authors.lastname: Dymecki
authors.forename: Janan T
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authors.forename: Franziska B
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authors.lastname: Grieder
authors.forename: Nathaniel
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authors.lastname: Heintz
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authors.lastname: Hicks
authors.forename: Thomas R
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authors.forename: Alexandra
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authors.lastname: Joyner
authors.forename: Beverly H
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authors.lastname: Koller
authors.forename: K C Kent
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authors.forename: Terry
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authors.lastname: Magnuson
authors.forename: Mark W
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authors.lastname: Moore
authors.forename: Andras
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authors.lastname: Nagy
authors.forename: Jonathan D
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authors.lastname: Pollock
authors.forename: Allen D
authors.initials: AD
authors.lastname: Roses
authors.forename: Arthur T
authors.initials: AT
authors.lastname: Sands
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authors.lastname: Seed
authors.forename: William C
authors.initials: WC
authors.lastname: Skarnes
authors.forename: Jay
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authors.lastname: Snoddy
authors.forename: Philippe
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authors.lastname: Soriano
authors.forename: David J
authors.initials: DJ
authors.lastname: Stewart
authors.forename: Francis
authors.initials: F
authors.lastname: Stewart
authors.forename: Bruce
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authors.lastname: Stillman
authors.forename: Harold
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authors.lastname: Varmus
authors.forename: Lyuba
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authors.lastname: Varticovski
authors.forename: Inder M
authors.initials: IM
authors.lastname: Verma
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Vogt
authors.forename: Harald
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authors.lastname: von Melchner
authors.forename: Jan
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authors.lastname: Witkowski
authors.forename: Richard P
authors.initials: RP
authors.lastname: Woychik
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wurst
authors.forename: George D
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authors.lastname: Yancopoulos
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Young
authors.forename: Brian
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authors.lastname: Zambrowicz
mesh_terms: D000483:Alleles; D000818:Animals; D036281:Genetic Research; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D035845:Research Embryo Creation / Q000191:economics