A single-centre assessment of long-term quality-of-life status after sibling allogeneic stem cell transplantation for chronic myeloid leukaemia in first chronic phase.
A total of 75 patients underwent sibling allogeneic stem cell transplantation (SCT) for chronic myeloid leukaemia in first chronic phase from 1984 to 2000. Of these patients, 51 (68%) were alive at a median follow-up of 98 months (range 34-217 months). Nine (18%) patients relapsed and seven (14%) received donor lymphocyte transfusions. Quality of life (QoL) was assessed cross-sectionally using the EORTC QLQ-C30, a Leukaemia-BMT-specific module and questionnaires on sexual functioning, fertility and late effects. A total of 46 (90%) replied. Scores for Role (P=0.018) and Cognitive (P<0.001) function were significantly lower when compared to an age-adjusted general population. Dyspnoea (P=0.022) and Financial Difficulties (P<0.001) were significantly more common in the SCT group. No difference was found for scores in the Physical, Emotional and Social domains or the overall Global Health Status/QoL. Decreased sexual functioning was found in one-third of respondents. Although most BMT recipients reported a good QoL, a minority have difficulty with reintegration into professional roles and consequent monetary problems. Identified cognitive and sexual impairments highlight the need for long-term access to psychosocial support.
Hayden
P J
PJ
Department of Haematology, St James's Hospital and University of Dublin, Trinity College, Dublin, Ireland. haydenpj@eircom.net
Keogh
F
F
Ni Conghaile
M
M
Carroll
M
M
Crowley
M
M
Fitzsimon
N
N
Gardiner
N
N
Vandenberghe
E
E
O'Riordan
J
J
McCann
S R
SR
D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D001787:Blood Group Incompatibility; D016026:Bone Marrow Transplantation / Q000523:psychology; D003072:Cognition Disorders / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000523:psychology* / Q000628:therapy*; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D011613:Psychotherapy; D011788:Quality of Life; D012189:Retrospective Studies; D012725:Sexual Behavior; D035781:Siblings; D033581:Stem Cell Transplantation / Q000523:psychology*; D011795:Surveys and Questionnaires; D013997:Time Factors; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System