[Catatonia or depression: the GC rat strain as an animal model of psychopathology].
The utility of "incomplete" genetic animal models of human diseases, in particular, psychoses, is discussed. The GC rat strain selected for predisposition to cataleptic reactions is described. It is shown that in many of their characteristics, GC rats are similar to schizophrenic and depressive patients. A possibility that akinetic catatonic states and depressions, hyperkinetic catatonic states and mania share common mechanisms is discussed. It is hypothesized that the GC strain may be an incomplete model of the common genetic and pathogenetic core of schizophrenic substuporous states and depression, which suggests the importance of returning to the issue of a unitary psychosis (Einheitpsychosis).
Kolpakov
V G
VG
Kulikov
A V
AV
Alekhina
T A
TA
Chuguĭ
V F
VF
Petrenko
O I
OI
Barykina
N N
NN
D000818:Animals; D002389:Catatonia / Q000235:genetics*; D003863:Depression / Q000235:genetics*; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D051381:Rats