[The expressions of Ki67 and VEGF in squamous cell carcinoma of larynx and the correlation between the two marks].
OBJECTIVE
To investigate the expression of Ki67 and VEGF in squamous cell carcinoma of larynx and the correlation between Ki67 and VEGF.


METHODS
The expression of Ki67 and VEGF in squamous cell carcinoma of larynx tissues of 40 cases were studied by immunohistochemical staining.


RESULTS
The expression of Ki67 and VEGF in squamous cell carcinoma of larynx tissues were higher than those in mucosa of laryngeal cavity (P<0.01). The expression of the two marks in squamous cell carcinoma of larynx with the metastasis of lymph nodes were higher than those without metastasis (Ki67: P<0.05, VEGF: P<0.01). Age and sex did not change the expression obviously (P>0.05). There was a positive correlation between T-stage and immunohistochemical staining (P<0.05). There was also a positive correlation in staining intensity between Ki67 and VEGF (r = 0.823, P<0.01).


CONCLUSIONS
Ki67 and VEGF are objective marks to estimate the behaviors of squamous cell carcinoma of larynx, and they can do help to the diagnosis, the judgment of stages and the treatment of carcinoma of larynx.
Sun
Dawei
D
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang
Yanjun
Y
Kong
Weijia
W
Liu
Banghua
B
Chen
Xiong
X
Zhang
Dan
D
Zhang
Sulin
S
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D042442:Vascular Endothelial Growth Factors / Q000096:biosynthesis*
D019394:Ki-67 Antigen; D042442:Vascular Endothelial Growth Factors