Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis.
We performed mRNA in situ hybridization for TNF-alpha and IL-1beta from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1beta mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.
Kim
Young S
YS
Division of Infectious Diseases, Drexel University College of Medicine, Philadelphia, PA, USA.
Honkaniemi
Jari
J
Sharp
Frank R
FR
Täuber
Martin G
MG
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D005786:Gene Expression Regulation; D006801:Humans; D017403:In Situ Hybridization; D007375:Interleukin-1 / Q000235:genetics / Q000378:metabolism*; D008586:Meningitis, Pneumococcal / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013290:Streptococcal Infections / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha