Lack of DNA copy number alterations revealed with comparative genomic hybridization in fibroadenomas of the breast.
There are very few studies reporting DNA copy number changes in fibroadenomas of the breast. Using comparative genomic hybridization, we analyzed 20 paraffin-embedded samples of fibroadenomas of the breast from patients with no familial or previous history of breast cancer. No alterations in the DNA copy number were observed in any of the tumors analyzed, regardless of the chromosomal alterations observed using conventional cytogenetic analysis. We discuss our results and compare them to other reports on fibroadenomas.
Cavalli
Luciane R
LR
Institute for Molecular and Human Genetics, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road NW, Main 4000, Washington, DC 20007, USA.
Cornelio
Deborah A
DA
Lima
Rubens S
RS
Urban
Cicero A
CA
Rone
Janice D
JD
Cavalli
Iglenir J
IJ
Haddad
Bassem R
BR
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000235:genetics*; D030561:Databases, Nucleic Acid; D005260:Female; D018226:Fibroadenoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D009693:Nucleic Acid Hybridization
D004273:DNA, Neoplasm