Comparison of effects of quinapril versus enalapril on vasoactive substances following acute myocardial infarction.
The true existence of a class effect in angiotensin-converting enzyme (ACE) inhibitors remains controversial. The present trial explored the effects of 2 ACE inhibitors after acute myocardial infarction and found no difference in endothelin-1 production but a greater increase in the production of total nitric oxide with quinapril than with enalapril.
Tsikouris
James P
JP
School of Pharmacy, Texas Tech Univesity Health Sciences Center, Lubbock 79430-9410, USA.
Simoni
Jan
J
Suarez
Jose A
JA
Sutthiwan
Piraon
P
Ziska
Martin
M
Meyerrose
Gary E
GE
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D001808:Blood Vessels / Q000187:drug effects* / Q000503:physiopathology; D004656:Enalapril / Q000494:pharmacology* / Q000627:therapeutic use; D019332:Endothelin-1 / Q000097:blood / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D009569:Nitric Oxide / Q000097:blood; D000077583:Quinapril; D044005:Tetrahydroisoquinolines / Q000494:pharmacology* / Q000627:therapeutic use
D000806:Angiotensin-Converting Enzyme Inhibitors; D019332:Endothelin-1; D044005:Tetrahydroisoquinolines; D009569:Nitric Oxide; D004656:Enalapril; D000077583:Quinapril