title: [Histopathological findings in cytomegalovirus retinitis].
abstract: OBJECTIVE
  We examined eyeballs collected from autopsied acquired immunodeficiency syndrome patients with cytomegalovirus (CMV) retinitis, and analyzed the precise pathogenesis of CMV retinitis.
  
  
  METHODS
  Eyeballs were fixed with 10% buffered formalin embedded in paraffin. CMV antigens were investigated by histopathological and immunohistochemical analyses. Histopathological findings were compared with funduscopic images.
  
  
  RESULTS
  CMV antigens remained in the necrotic area of the retina and many CMV immediate early antigens existed in intact parts of the inner retina showing almost intact structure, and around retinal vessels.
  
  
  CONCLUSIONS
  The results suggest that CMV infects the inner retina first via the retinal vessels, although funduscopic examination may appear normal. It extends through the neuronal cells and glial cells horizontally and Muller cells vertically. CMV severely damages the retinal structure.
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Japan.
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Kashiwase
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sata
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nagata
authors.forename: Norio
authors.initials: N
authors.lastname: Usui
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Fujino
authors.forename: Takuya
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kurata
authors.forename: Masahiko
authors.initials: M
authors.lastname: Usui
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000473:pathology* / Q000821:virology; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology; D017726:Cytomegalovirus Retinitis / Q000473:pathology* / Q000821:virology; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology* / Q000821:virology; D013194:Staining and Labeling
chemical_list: D000956:Antigens, Viral; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin