Early colon cancers detected by FDG-pet: a report of two cases with immunohistochemical investigation.
Increased glucose uptake is one of the metabolic characteristics of tumor cells. 18F-fluorodeoxyglucose (FDG)-positron emission tomography (FDG-PET), a technique that is used widely to study this altered glucose metabolism in tumors, allows the detection of various types of malignancy. We present herein two cases of early colon cancers detected incidentally by FDG-PET. The technique was used as part of the screening examinations for preoperative staging, and for postoperative follow-up. In both cases, the lesions were removed by colonoscopic polypectomy, with no complications. Moreover, we confirmed the existence of altered glucose metabolism in the resected specimen by immunohistochemical staining using an antibody raised against Glut1. Immunohistochemically, Glut1 was expressed in vitro in both of the lesions, supporting the positive FDG-PET result obtained in vivo. To our knowledge, this is the first report to describe in vitro Glut1 expression and in vivo tumor detection using FDG-PET in colorectal carcinoma.
Okuno
Tatsuya
T
Division of Gastrointestinal Oncology and Endoscopy, National Cancer Center Research Institute East, Chiba, Japan.
Fu
Kuang-I
KI
Sano
Yasushi
Y
Yoshino
Takayuki
T
Murakami
Kouji
K
Ochiai
Atsushi
A
Yoshida
Shigeaki
S
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001786:Blood Glucose / Q000378:metabolism*; D012809:Colon, Sigmoid / Q000473:pathology / Q000601:surgery; D003111:Colonic Polyps / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D019788:Fluorodeoxyglucose F18; D051272:Glucose Transporter Type 1; D006801:Humans; D008168:Lung / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009004:Monosaccharide Transport Proteins / Q000032:analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011237:Predictive Value of Tests; D012811:Sigmoid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D014055:Tomography, Emission-Computed; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor; D001786:Blood Glucose; D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; C495677:SLC2A1 protein, human; D019788:Fluorodeoxyglucose F18