title: Comparison between single-beat and multiple-beat methods for estimation of right ventricular contractility.
abstract: OBJECTIVE
  It was investigated whether pharmacologically induced changes in right ventricular contractility can be detected by a so-called "single-beat" method that does not require preload reduction.
  
  
  METHODS
  Prospective animal research.
  
  
  METHODS
  Laboratory at a large university medical center.
  
  
  METHODS
  Eight anesthetized pigs.
  
  
  METHODS
  End-systolic elastance values obtained by a recently proposed single-beat method (Eessb) were compared with those obtained using the reference multiple-beat method (Eesmb).
  
  
  RESULTS
  Administration of dobutamine increased Eesmb from 1.6 +/- 0.3 to 3.8 +/- 0.5 mm Hg/mL (p =.001), whereas there was only a trend toward an increase in Eessb from 1.5 +/- 0.2 to 1.7 +/- 0.4 mm Hg/mL. Esmolol decreased Eesmb from 1.7 +/- 0.3 to 1.1 +/- 0.2 mm Hg/mL (p =.006), whereas there was only a trend for a decrease in Eessb from 1.5 +/- 0.2 to 1.3 +/- 0.1.
  
  
  CONCLUSIONS
  The present method using single-beat estimation to assess right ventricular contractility does not work as expected, since it failed to detect either increases or decreases in right ventricular contractility induced by pharmacologic interventions.
authors.affiliation: Hemodynamic Research Center, University of Liege, Liege, Belgium.
authors.forename: Bernard
authors.initials: B
authors.lastname: Lambermont
authors.forename: Patrick
authors.initials: P
authors.lastname: Segers
authors.forename: Alexandre
authors.initials: A
authors.lastname: Ghuysen
authors.forename: Vincent
authors.initials: V
authors.lastname: Tchana-Sato
authors.forename: Philippe
authors.initials: P
authors.lastname: Morimont
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dogne
authors.forename: Philippe
authors.initials: P
authors.lastname: Kolh
authors.forename: Paul
authors.initials: P
authors.lastname: Gerard
authors.forename: Vincent
authors.initials: V
authors.lastname: D'Orio
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization; D002316:Cardiotonic Agents; D004280:Dobutamine; D006334:Heart Function Tests / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology*; D011446:Prospective Studies; D013552:Swine; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine