[Detection of antibody against Borna disease virus-p24 in the plasma of Chinese patients with chronic fatigue syndrome by Western-blot analysis].
OBJECTIVE
To evaluate the prevalence of infection with Borna disease virus (BDV) in Chinese patients with chronic fatigue syndrome (CFS) and control subjects, and to discuss the etiological association between CFS and infection with BDV.


METHODS
The CDC (1994) diagnostic criteria for CFS were used for case definition. Sixty-one patients suffered from CFS were from 11 Provinces in China. To detect the antibody against BDV-p24 on the plasma samples from all cases and 73 healthy control subjects by Western-blotting analysis.


RESULTS
7 of the sixty-one cases and 0 of the controls were sero-positive for BDV-p24 antibody, there was a statistical significant difference between the two groups (11.48% vs 0%; P less than 0.010).


CONCLUSIONS
Chinese patients with CFS showed sero-positive identifying BDV infection, by comparison, anti.BDV-p24 antibody prevalence in patients was significantly higher than in controls. An etiological association may exist between CFS and BDV infection.
Li
Yong-jie
YJ
Department of Neurology, Beijing Friendship Hospital, Beijing 100050, China.
Wang
De-xin
DX
Zhang
Feng-min
FM
Liu
Zhan-dong
ZD
Yang
Ai-ying
AY
Ykuta
K
K
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D015153:Blotting, Western; D001890:Borna Disease / Q000150:complications* / Q000276:immunology; D001891:Borna disease virus / Q000276:immunology*; D015673:Fatigue Syndrome, Chronic / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral