title: Nucleophilic alkylations of 3-nitropyridines.
abstract: 3-Nitropyridine and 4-substituted-3-nitropyridines were reacted with chloroform, methyl chloroacetate and ethyl 2-chloropropionate under vicarious nucleophilic substitution (VNS) conditions. Substitution was obtained in the ortho or para position to the nitro group with acceptable to good yields and regioselectivity. With potassium 5-nitropyridine-2-sulfonate the substitution took place in the 4-position. Further substitution of the sulfonate group proved to be possible.
authors.affiliation: Department of Chemistry, Norwegian University of Science and Technology, Sem Saelandsvei 8, NO-7491, Trondheim, Norway.
authors.forename: Einar J
authors.initials: EJ
authors.lastname: Andreassen
authors.forename: Jan M
authors.initials: JM
authors.lastname: Bakke
authors.forename: Ingrid
authors.initials: I
authors.lastname: Sletvold
authors.forename: Harald
authors.initials: H
authors.lastname: Svensen