Identification of a mouse orthologue of the G-protein-coupled receptor SALPR and its expression in adult mouse brain and during development.
The mouse orthologue of somatostatin and angiotensin-like peptide receptor (SALPR) was amplified from cDNA of the hippocampal cell line HT22. It coded for a protein of 472 amino acids showing 84% sequence identity with human SALPR and 43% with human G-protein-coupled receptor 100 (GPR100). A distinct pattern of expression in brain, spinal cord, and dorsal root ganglia during development and in the mature brain hint at important functions of SALPR for differentiation and maintenance of the nervous system.
Boels
Katrin
K
Zentrum für Molekulare Neurobiologie, Universität Hamburg, Martinistrasse 52, 20246 Hamburg, Germany.
Hermans-Borgmeyer
Irm
I
Schaller
H Chica
HC
D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D002478:Cells, Cultured; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000032:analysis / Q000235:genetics; D005727:Ganglia, Spinal / Q000254:growth & development / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D018000:Receptors, Peptide / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013116:Spinal Cord / Q000254:growth & development / Q000378:metabolism
D018076:DNA, Complementary; C410092:RXFP3 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; C505050:SALPR protein, mouse