Briarane diterpenes from two species of octocorals, Ellisella sp. and Pteroeides sp.
Eight new briarane diterpenes (1-4, 7-10) have been isolated from two species of octocorals and the structures elucidated by spectroscopic analysis. Two diterpenes (2, 3) from the gorgonian Ellisella sp. inhibited cytokinesis, causing multinuclei formation on NBT-II cells, while a known briarane (12) from the sea pen Pteroeides sp. showed reversal of multidrug resistance.
Tanaka
Chiaki
C
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
Yamamoto
Yumiko
Y
Otsuka
Masahito
M
Tanaka
Junichi
J
Ichiba
Toshio
T
Marriott
Gerard
G
Rachmat
Rachmaniar
R
Higa
Tatsuo
T
D000818:Animals; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007564:Japan; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D004224:Diterpenes