Peptide selection by class I molecules of the major histocompatibility complex.
Class I molecules of the major histocompatibility complex (MHC) bind peptides derived from cytoplasmic proteins. Comparison of over 100 such peptides reveals the importance of the carboxy-terminal residue in selective binding. Recent evidence implicates the proteases and transporters of the processing pathway in providing peptides with the correct residues at the carboxyl terminus.
Elliott
T
T
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Smith
M
M
Driscoll
P
P
McMichael
A
A