title: Optimizing a hydroxyapatite/tricalcium-phosphate ceramic as a bone graft extender for impaction grafting.
abstract: The mechanical properties of morsellized bone allografts and synthetic hydroxapatite/tricalcium-phosphate (HA/TCP) ceramic extender materials for the use in impaction grafting revision hip surgery were investigated using two test methods: a basic compression test and an endurance test in an in-vitro model of an impaction grafted femur. Formalin fixed ovine bone graft was identified as mechanically similar to fresh human bone and thus suitable as an experimental material for in-vitro testing. For 1 : 1 volumetric mixes of bone allograft and synthetic extender, the granular ceramic's properties were varied in porosity, chemical composition, sintering temperature and particle size. Initial mechanical stability, a crucial prerequisite for clinical success in impaction grafting, was increased for all bone/extender mixes. A high porosity, tricalcium-phosphate rich ceramic of medium particle size and sintered at high temperatures was recognized as an optimized extender material for impaction grafting balancing the mechanical and biological demands. Using the extender without bone graft as a pure replacement is not recommended.
authors.affiliation: Department of Mechanical Engineering, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
authors.forename: B
authors.initials: B
authors.lastname: Grimm
authors.forename: A W
authors.initials: AW
authors.lastname: Miles
authors.forename: I G
authors.initials: IG
authors.lastname: Turner