title: Comparison of an allograft in an experimental putty carrier and a bovine-derived xenograft used in ridge preservation: a clinical and histologic study in humans.
abstract: OBJECTIVE
  The aim of this randomized, controlled, blinded clinical study was to compare ridge dimensions and histologic characteristics of ridges preserved with 2 different graft materials.
  
  
  METHODS
  Twenty-four subjects, each requiring a nonmolar extraction and delayed implant placement, were randomly selected to receive ridge preservation treatment with either an allograft in an experimental putty carrier plus a calcium sulfate barrier (PUT) or a bovine-derived xenograft (BDX) plus a collagen membrane. Horizontal and vertical ridge dimensions were determined using a digital caliper and a template. At 4 months postextraction, a trephine core was obtained for histologic analysis.
  
  
  RESULTS
  The average ridge width decreased by 0.50 mm for both groups (P < .05). The midbuccal vertical change for the PUT group was a loss of 0.3+/-0.7 mm versus a gain of 0.7+/-1.2 mm for the BDX group, a difference of 1.0 mm (P > .05). Histologic analysis revealed vital bone in the PUT group of about 61%+/-9% versus 26%+/-20% for the BDX group (P < .05).
  
  
  CONCLUSIONS
  Greater vital bone fill in the PUT group may be attributable to earlier and greater vascular invasion of the carrier material. The putty material was characterized by ease of handling, simple placement, and enhanced graft particle containment.
  
  
  CONCLUSIONS
  Allograft mixed with an experimental putty carrier produced significantly more vital bone fill than did the use of a xenograft with no carrier material. Ridge width and height dimensions were similarly preserved with both graft materials.
authors.affiliation: Private Practice, Lexington, Kentucky, USA.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Vance
authors.forename: Henry
authors.initials: H
authors.lastname: Greenwell
authors.forename: Richard L
authors.initials: RL
authors.lastname: Miller
authors.forename: Margaret
authors.initials: M
authors.lastname: Hill
authors.forename: Hudson
authors.initials: H
authors.lastname: Johnston
authors.forename: James P
authors.initials: JP
authors.lastname: Scheetz
mesh_terms: D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D002133:Calcium Sulfate; D002266:Carboxymethylcellulose Sodium; D002417:Cattle; D003094:Collagen; D004311:Double-Blind Method; D004337:Drug Carriers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals; D020390:Tooth Socket
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D004337:Drug Carriers; D008903:Minerals; D003094:Collagen; D002266:Carboxymethylcellulose Sodium; D002133:Calcium Sulfate