The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats.
Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.
Banno
Ryouichi
R
Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Arima
Hiroshi
H
Sato
Ikuko
I
Hayashi
Masayuki
M
Goto
Motomitsu
M
Sugimura
Yoshihisa
Y
Murase
Takashi
T
Oiso
Yutaka
Y
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005951:Glucose Tolerance Test; D006706:Homeostasis / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats; D020334:Rats, Inbred OLETF; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D000521:alpha-MSH / Q000819:agonists* / Q000031:analogs & derivatives* / Q000494:pharmacology*
D010456:Peptides, Cyclic; D014280:Triglycerides; C079282:melanotan-II; D000521:alpha-MSH