[Effects of Shendan Jianyi Capsule on aldose reductase activity of kidney in diabetic rats].
OBJECTIVE
To evaluate the effects of Shendan Jianyi Capsule (SDJYC) on aldose reductase (AR) activity of the kidney in diabetic rats and the significance of prevention and treatment of diabetic nephropathy with Chinese natural herbs.


METHODS
Diabetic Wistar rats were treated with SDJYC and sorbinil respectively, and the AR activity in kidney, urine protein and the activity of Na(+)-K(+)-ATPase were tested.


RESULTS
The AR activity in diabetic rats was decreased obviously after being treated with sorbinil or SDJYC. The activity of Na(+)-K(+)-ATPase in diabetic rats decreased obviously at the end of the eighth week, and increased after being treated with sorbinil and SDJYC. There was no difference between two treated groups after the treatment. It demonstrated that the inhibition of AR activity could improve the activity of Na(+)-K(+)-ATPase and SDJYC had the same effect.


CONCLUSIONS
SDJYC exerts effects by inhibiting the activity of AR.
Fang
Zhao-Hui
ZH
Department of Metabolism and Endocrinology, First Affiliated Hospital, Anhui College of Traditional Chinese Medicine, Hefei, Anhui Province 230031, China. fangzhaohui@medmail.com.cn
Zhang
Xiao-Ping
XP
Bao
Dao-Lin
DL
Xu
Yi
Y
Luo
Le
L
Zhou
Jun
J
D000449:Aldehyde Reductase / Q000378:metabolism*; D000818:Animals; D002214:Capsules; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008516:Medicine, Chinese Traditional; D011507:Proteinuria / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013311:Streptozocin
D002214:Capsules; D013311:Streptozocin; D000449:Aldehyde Reductase; D000254:Sodium-Potassium-Exchanging ATPase