[A successfully resected case of colorectal cancer with multiple liver metastases treated with systemic chemotherapy].
The patient was a-54-year-old man. Sigmoidectomy was performed for sigmoid colon cancer in 1991. Partial liver resection in 1992 and microwave coagulation therapy (MCT) in 1994 were carried out for liver metastasis. Complete remission of the metastasis was achieved. In June 2002, multiple liver and lung metastases were identified. 5-FU, CDDP therapy was applied as systemic chemotherapy. The liver metastasis was improved and the level of CEA was reduced. However, a new lesion appeared in the right lobe of the liver, followed by an increase of the CEA level. Although CPT-11, 5-FU, CDDP therapy was applied, it was not effective. The reason was considered to be from the decrease of drug delivery resulting from an unbalanced blood supply in the right lobe of the liver. Right lobectomy and radio-frequency ablation was performed on June 17, 2003. The level of CEA was dramatically decreased. Additionally, CPT-11, 5-FU, CDDP therapy was applied. The patient has survived for 11 years after liver metastasis was first detected.
Sugiyama
Shinichi
S
Dept of Gastroenterological Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University.
Beppu
Toru
T
Ishiko
Takatoshi
T
Doi
Kohichi
K
Nakagawa
Masahide
M
Tanaka
Hideyuki
H
Morinaga
Hiroshi
H
Yamane
Takaaki
T
Egami
Hiroshi
H
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002945:Cisplatin / Q000008:administration & dosage; D012809:Colon, Sigmoid / Q000601:surgery; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004564:Electrocoagulation; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D008297:Male; D008872:Microwaves / Q000627:therapeutic use; D008875:Middle Aged; D012811:Sigmoid Neoplasms / Q000473:pathology* / Q000601:surgery; D017741:Survivors
D000077146:Irinotecan; D002945:Cisplatin; D005472:Fluorouracil; D002166:Camptothecin