[Unexpected occurence of hemoglobin Athens-Georgia].
The following report concerned a 47 year old Caucasian diabetic patient. Routine HPLC of HbA1c (Variant II Biorad Laboratories - hemoglobin A1c program) resulted only in the evidence of HbF (1%) and increase in HbA1c (10%). Considering the presence of HbF a standard agarose gel electrophoresis of patient's hemoglobin was performed and revealed the presence of Hb Athens-Georgia. Consequently the occurrence of HbF during determination of HbA1c by HPLC should lead to perform a standard hemoglobin electrophoresis in order to explore an hidden, unsuspected and clinically silent occurrence of rare Hb variant or additional unsuspected increase in HbA2.
Granouillet
R
R
Laboratoire de biochimie, CHU-hôpitaux de Saint Etienne, hôpital Nord.
Atieh
S
S
Francina
A
A
Raby
N
N
Olaru
D
D
Chamson
A
A
Perier
C
C
D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006455:Hemoglobins, Abnormal; C060131:hemoglobin Athens-Georgia