Clinical characterization of idiopathic intracranial hypertension at the Detroit Medical Center.
BACKGROUND
Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri (PTC), is a condition characterized by increased intracranial pressure without clinical, laboratory or radiologic evidence of an intracranial space-occupying lesion, meningeal inflammation or venous outflow obstruction. Previous population-based studies evaluated the presenting clinical features of IIH in North-Eastern Libya, Iowa, Louisiana, Minnesota, Northern Ireland, Israel and Western Turkey. However, we report the demographic patterns of a metropolitan North American city.


METHODS
We performed a retrospective study of all patients with an initial IIH diagnosis and follow-up at the Detroit Medical Center (DMC), Michigan from 1985 to 2002. Medical records of 174 patients were reviewed, with 77 patients fitting the diagnostic criteria.


RESULTS
Seventy-seven patients, 71 females (92.2%) and 6 males (7.8%) were identified. Age ranged from 10 to 50 years, with a mean of 34 years. Fifty patients (65%) were African-American and 24 patients (31%) were Caucasian. The most common presentation was isolated headache (28.6%). Nineteen patients (24.7%) were asymptomatic. Obesity was described in 65 of 74 patients (87.8%) evaluated for body dimensions.


CONCLUSIONS
We report an increased number of asymptomatic patients after routine ophthalmic examination. Obese females in metropolitan Detroit would benefit from routine eye evaluations to avoid potential visual loss related to papilledema.
Galvin
Jennifer A
JA
Departments of Neurology and Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, 4717 St. Antoine Blvd. Detroit, MI 48201, USA.
Van Stavern
Gregory P
GP
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000209:etiology; D006767:Hospitals, District; D006801:Humans; D015994:Incidence; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000209:etiology; D011559:Pseudotumor Cerebri / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D012189:Retrospective Studies; D017678:Sex Distribution