[Plasminogen activator of urokinase-type: mechanisms of involvement in vessel remodeling and angiogenesis, gene therapy approaches to ischemia].
The review summarizes data obtained by the authors and other laboratories concerning the role of urokinase plasminogen activator in vessel remodeling and angiogenesis. The data have shown that urokinase is involved in unfavorable vascular remodeling during the development of restenosis, atherosclerosis and also in the regulation of angiogenesis. Urokinase is a promising target for therapeutic interventions aimed at restenosis prevention. Urokinase gene therapy may be a perspective strategy for the treatment of tissue ischemia.
Parfenova
E V
EV
Plekhanova
V V
VV
Stepanova
V V
VV
Men'shikov
M Iu
MIu
Tsokaleva
Z I
ZI
Talitskiĭ
K A
KA
Rakhmat-zade
T M
TM
Traktuev
D O
DO
Torosian
N A
NA
Rogunova
N I
NI
Ratner
E I
EI
Tkachuk
V A
VA
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology / Q000628:therapy*; D015316:Genetic Therapy; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000628:therapy*; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000235:genetics; D010960:Plasminogen Activators / Q000008:administration & dosage* / Q000235:genetics; D051381:Rats; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage* / Q000235:genetics
D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator