Tumor metastasis: a new twist on epithelial-mesenchymal transitions.
Epithelial-mesenchymal transitions are essential for normal embryonic development and for progression of non-invasive tumor cells into malignant, metastatic carcinomas. Twist, an important regulator of morphogenesis in the embryo, has recently been implicated in the onset of invasive behavior during tumor progression.
Vernon
Ann E
AE
Robert H. Lurie Comprehensive Cancer Center, Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
LaBonne
Carole
C
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism; D004848:Epithelium / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D008648:Mesoderm / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009687:Nuclear Proteins / Q000378:metabolism* / Q000502:physiology; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology; D051879:Twist-Related Protein 1
D015820:Cadherins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D051879:Twist-Related Protein 1