PER-1 production in a urinary isolate of Providencia rettgeri.
A Providencia rettgeri strain resistant to extended-spectrum cephalosporins and intermediate to aztreonam was isolated from the urine of a patient hospitalized in the urology clinic of SSK Educational Hospital in Ankara. Clavulanic acid restored the activity of extended-spectrum cephalosporins, suggesting that the strain was harboring an extended-spectrum beta-lactamase. Since the PER-1 enzyme is widespread in Turkey, and had been already detected in a related species such as Proteus mirabilis, the Providencia strain was suspected of harboring a PER-1 enzyme, which was indeed detected by PCR. This is the first description in a P. rettgeri isolate of a PER-1 enzyme which is widespread among Acinetobacter baumanni and Pseudomonas aeruginosa strains in Turkey.
Bahar
G
G
SSK Educational Hospital Clinical Microbiology, Ankara, Turkey. gulbahkar@hotmail.com
Eraç
B
B
Mert
A
A
Gülay
Z
Z
D001483:Base Sequence; D002511:Cephalosporins / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000032:analysis; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000652:urine; D006801:Humans; D015994:Incidence; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011532:Providencia / Q000145:classification / Q000187:drug effects* / Q000201:enzymology*; D014421:Turkey / Q000453:epidemiology; D016482:Urinalysis; D014556:Urine / Q000382:microbiology*; D001618:beta-Lactamases / Q000378:metabolism*
D002511:Cephalosporins; D004269:DNA, Bacterial; C108863:beta-lactamase PER-1; D001618:beta-Lactamases