Integrin and the Reelin-Dab1 pathway: a sticky affair?
It has been repeatedly suggested that integrin is essential for neuronal migration. A new study proposes a link between Disabled-1 (Dab1) phosphorylation and alpha3 integrin signalling that is thought to drive the timely detachment of migrating neurons from the guiding radial glia fibers during early corticogenesis. This proposal however is hardly compatible with time-lapse anatomical investigations and genetic studies on integrin or with recent works which indicate direct reelin signalling to radial fibers.
Luque
Juan M
JM
Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, Campus de San Juan s/n, E-03550 San Juan de Alicante, Alicante, Spain. luque@umh.es
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D015816:Cell Adhesion Molecules, Neuronal; C115785:DAB1 protein, human; D016326:Extracellular Matrix Proteins; D016023:Integrins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; D012697:Serine Endopeptidases