title: Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice.
abstract: Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.
authors.affiliation: MiraVista Diagnostics/MiraBella Technologies, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241, USA.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Durkin
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Connolly
authors.forename: Kian
authors.initials: K
authors.lastname: Karimi
authors.forename: Emerson
authors.initials: E
authors.lastname: Wheat
authors.forename: Carol
authors.initials: C
authors.lastname: Schnizlein-Bick
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Allen
authors.forename: Katia
authors.initials: K
authors.lastname: Alves
authors.forename: Ram P
authors.initials: RP
authors.lastname: Tewari
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Keath
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006658:Histoplasma / Q000145:classification* / Q000302:isolation & purification; D006660:Histoplasmosis / Q000473:pathology*; D007843:Latin America; D051379:Mice; D009656:North America