title: [Role of cytomegalovirus infection in the pathogenesis of type 2 diabetes mellitus].
abstract: OBJECTIVE
  To further study the role of human cytomegalovirus (HCMV) infection in the pathogenesis of the type 2 diabetes mellitus.
  
  
  METHODS
  HCMV DNA levels in sera from 29 type 2 diabetic patients and 23 controls were measured by quantitative polymerase chain reaction (PCR), and comparative analyses was made between HCMV DNA and T cell subsets, blood glucose (BG), insulin (Ins) and C peptide (C-P).
  
  
  RESULTS
  The levels of HCMV DNA were (1.81+/-1.67) x 10(8) copies/ml for type 2 diabetic patients, a level significantly higher than that (5.50+/-4.30) x 10(7) copies/ml of controls. The percentage of CD8 for type 2 diabetic patients with positive HCMV DNA was 29.53%+/-2.00%, being much higher than that for controls (27.13%+/-4.12%), while the ratio of CD4/CD8 1.24+/-0.05 was significantly lower than that 1.41+/-0.10 of controls. Fasting C-P of type 2 diabetic patients with positive HCMV DNA was far lower than that of those with negative HCMV DNA, but the differences of BG and Ins between the two groups were not significant.
  
  
  CONCLUSIONS
  Active HCMV infection of type 2 diabetic patients may suppress cellular immunity and its influence on the pathogenesis of the type 2 diabetes mellitus should be further studied.
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning 530021, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liang
authors.forename: Yu-zhen
authors.initials: YZ
authors.lastname: Liang
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Zhi-qing
authors.initials: ZQ
authors.lastname: Yu
authors.forename: Jie-han
authors.initials: JH
authors.lastname: Su
authors.forename: Zhi-bin
authors.initials: ZB
authors.lastname: Wu
authors.forename: Jin-yao
authors.initials: JY
authors.lastname: Qin
mesh_terms: D000328:Adult; D003587:Cytomegalovirus / Q000235:genetics*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology; D004279:DNA, Viral / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D016176:T-Lymphocyte Subsets
chemical_list: D004279:DNA, Viral