title: Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
abstract: The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis. The elevated expression of these proteins in tumor cells and their post-translational modifications, such as phosphorylation, acetylation and methylation, are discussed and suggested as suitable targets for cancer chemotherapy.
authors.affiliation: Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, via L. Giorgieri 1, Università di Trieste, 34127 Trieste, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Sgarra
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rustighi
authors.forename: Michela A
authors.initials: MA
authors.lastname: Tessari
authors.forename: Julie
authors.initials: J
authors.lastname: Di Bernardo
authors.forename: Sandro
authors.initials: S
authors.lastname: Altamura
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fusco
authors.forename: Guidalberto
authors.initials: G
authors.lastname: Manfioletti
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Giancotti
mesh_terms: D000107:Acetylation; D000595:Amino Acid Sequence; D017209:Apoptosis / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D002843:Chromatin / Q000737:chemistry*; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000502:physiology*; D008745:Methylation; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000503:physiopathology*; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid
chemical_list: D002843:Chromatin; D006609:High Mobility Group Proteins