title: Can ends justify the means? Digging deep for human fusion genes of prokaryotic origin.
abstract: Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/
authors.affiliation: School of Mechanical and Production Engineering, Nanyang Center for Supercomputing and Visualization, Nanyang Technological University, Singapore 639798.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yiting
authors.forename: Iti
authors.initials: I
authors.lastname: Chaturvedi
authors.forename: Liew Kim
authors.initials: LK
authors.lastname: Meow
authors.forename: Pandjassarame
authors.initials: P
authors.lastname: Kangueane
authors.forename: Meena Kishore
authors.initials: MK
authors.lastname: Sakharkar
mesh_terms: D017398:Alternative Splicing; D005075:Biological Evolution; D030541:Databases, Genetic; D030562:Databases, Protein; D019143:Evolution, Molecular; D050939:Gene Fusion; D005798:Genes, Bacterial; D016678:Genome; D006801:Humans; D020407:Internet; D010802:Phylogeny; D011387:Prokaryotic Cells / Q000378:metabolism; D025941:Protein Interaction Mapping; D011993:Recombinant Fusion Proteins / Q000378:metabolism
chemical_list: D011993:Recombinant Fusion Proteins