title: A highly diastereoselective MgI2-mediated ring expansion of methylenecyclopropanes.
abstract: [reaction: see text] A highly diastereoselective MgI(2)-mediated ring expansion of methylenecyclopropane amides to functionalized pyrrolidines has been developed using chiral aromatic sulfinimines. The 2,3,4-trisubstituted pyrrolidines were isolated in generally good to excellent yields and in excellent diastereoselectivities for aromatic and heterocyclic sulfinimines.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Scott
authors.forename: Wooseok
authors.initials: W
authors.lastname: Han
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens