title: [Detection of Epstein-Barr virus in T cell lymphoma and clinicopathologic analysis].
abstract: BACKGROUND
  To study the relationship of Epstein-Barr virus (EBV) and T cell lymphoma.
  
  
  METHODS
  Sixty cases of T cell lymphomas were examined for the presence of EBV using in situ hybridization for EBV encoded RNA (EBERs).
  
  
  RESULTS
  EBERs were detected in tumor cells in 37(69.8%) of 53 cases with peripheral T cell lymphoma, but in none of seven cases of precursor T lymphoblastic lymphoma. The total detected EBERs were 37(61.6%) in 60 cases of T cell lymphomas. By Revised European-American Lymphoma(REAL) classification, EBERs were detected in 2/2 angioimmuno-blastic T cell lymphoma,17/18 angiocentric lymphoma, 4/6 anaplastic large cell lymphoma and 14/27 peripheral T cell lymphoma, unspecified (51.9%). The frequency of EBERs among the extranodal peripheral T cell lymphoma was higher than the nodal (P less than 0.01) there was no significant correlation with the sex, age and clinical stage.
  
  
  CONCLUSIONS
  This study indicated that high incidence of EBV was observed in peripheral T cell lymphoma, with predilection for angiocentric lymphoma and extranodal presentation.
authors.affiliation: Department of Pathology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Zu-gen
authors.initials: ZG
authors.lastname: He
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Huang
authors.forename: Xiu-chan
authors.initials: XC
authors.lastname: Guo
authors.forename: Dong-mei
authors.initials: DM
authors.lastname: Lin
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured
chemical_list: D004279:DNA, Viral