Visualizing the first 50 hr of the primary immune response to a soluble antigen.
Recently, static and dynamic imaging methods have produced the first glimpses of the interactions between antigen-specific T cells and peptide-MHC-bearing antigen-presenting cells in the lymph nodes. Using data from these experiments, we produced a numerically, spatially, and temporally scaled simulation of the first 50 hr of the primary T cell-dependent immune response. The simulation highlights how lymph node structure facilitates antigen presentation to rare, naive, antigen-specific CD4+ T cells.
Catron
Drew M
DM
Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA. catro001@umn.edu
Itano
Andrea A
AA
Pape
Kathryn A
KA
Mueller
Daniel L
DL
Jenkins
Marc K
MK
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D018715:Microscopy, Video; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*