Anticonvulsant potential of holy basil, Ocimum sanctum Linn., and its cultures.
Callus cultures from stem of O. sanctum were induced on slightly modified Murashige and Skoog's (MS) medium and supplemented with 2,4-dichlorophenoxyacetic acid (2,4-D, 1-2 ppm) and kinetin (kn, 1 ppm). Different extractives of stem, leaf and stem callus of O. sanctum were tested for anticonvulsant activity against standard drug phenytoin using maximal electroshock (MES) model. Ethanol and chloroform extractives of stem, leaf and stem calli were effective in preventing tonic convulsions induced by transcorneal electroshock.
Jaggi
Raj K
RK
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Madaan
Reecha
R
Singh
Balbir
B
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D051379:Mice; D031339:Ocimum / Q000737:chemistry*; D010672:Phenytoin / Q000008:administration & dosage / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018547:Plant Stems / Q000737:chemistry; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D000927:Anticonvulsants; D010936:Plant Extracts; D010672:Phenytoin