Structures of four new triterpenoid saponins from the leaves of Oplopanax elatus Nakai.
OBJECTIVE
Isolation and structural elucidation of the triterpenoid saponins of Oplopanax elatus Nakai.


METHODS
Solvent extraction and column chromatography were used to isolate the triterpenoid saponins, physico-chemical constants and spectroscopic analysis were employed for structural elucidation.


RESULTS
Four newtriterpenoid saponins named cirenshenoside S (1), cirenshenoside T (2), cirenshenoside U (3) and cirenshenoside V (4) were isolated, and their structures were elucidated to be 3-O-beta-D-glucopyranosyl 3beta,23-dihydroxylup-20 (29)-en-28-oic acid 28-O-alpha-L-rhamnopyranosyl (1 --> 4)-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranoside (1), 3-O-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1 --> 4)-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranoside (2), 3-O-beta-D-glucopyranosyl 3beta-hydroxyolean-9(11),12-dien-28-oic acid 28-O-alpha-L-rhamnopyranosyl (1 --> 4)-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranoside (3) and 3alpha-hydroxyolean-12-dien-23,28-dioic acid 28-O-alpha-L-rhamnopyranosyl (1 --> 4 )-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranoside (4), respectively.


CONCLUSIONS
Compounds 1-4 are new triterpenoid saponins and isolated from the leaves of Oplopanax elatus Nakai for the first time.
Wang
Guang-shu
GS
Pharmacy College, Jilin University, Changchun 130021, China. wangguangshu1001@163.com
Yang
Xiao-hong
XH
Xu
Jing-da
JD
D008968:Molecular Conformation; D015394:Molecular Structure; D028002:Oplopanax / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*
C493343:3-O-glucopyranosyl 3,23-dihydroxylup-20(29)-en-28-oic acid 28-O-rhamnopyranosyl-1-4-glucopyranosyl-1-6-glucopyranoside; C493344:3-O-glucopyranosyl 3-hydroxyolean-9(11),12-dien-28-oic acid 28-O-rhamnopyranosyl-1-4-glucopyranosyl-1-6-glucopyranoside; D012503:Saponins