title: Peak compression effects in capillary electrochromatography.
abstract: Peak compression in CEC is a phenomenon that can generate very narrow peaks with extremely high efficiencies that defy current chromatographic theory. This review article summarises the content of publications in this area up to this date. Two main types of peak compression effects have been observed in the literature. First, an irreproducible and hard to control focusing effect of unclear origin, observed on strong cation exchangers. Second, a reproducible continuous stacking effect caused by sample composition induced system zones demonstrated on several types of stationary phases.
authors.affiliation: Department of Analytical Chemistry, AstraZeneca, Process R&D, S-151 85 Södertälje, Sweden. anna-maria.enlund@astrazeneca.com
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Enlund
authors.forename: Margareta E
authors.initials: ME
authors.lastname: Andersson
authors.forename: Gunnar
authors.initials: G
authors.lastname: Hagman
mesh_terms: D002852:Chromatography, Ion Exchange; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*