title: Development and cell response of a new biodegradable composite scaffold for guided bone regeneration.
abstract: Composites of biodegradable polymers with different calcium phosphate ceramics and glasses, have been developed as scaffolds for applications in bone-tissue engineering. In this work, phosphate glass particles have been incorporated into the polymer, poly(95L/5DL) lactic acid (PLA) and porous structures were elaborated. Their porosity, compressive mechanical properties and biological response were evaluated. Interconnected structures with evenly distributed pores and a porosity as high as 97% were obtained. The incorporation of glass particles into the polymer showed to have a positive effect in the mechanical properties of the foams. Indeed, the compressive modulus increased from 74.5 to 120 KPa and the compressive strength from 17.5 to 20.1 KPa for the PLA and the PLA/glass foams, respectively. The biological response was evaluated by means of the MTT test, the materials resulted to be noncytotoxic.
authors.affiliation: CREB (Biomedical Engineering Research Center), Department of Material Science and Metallurgy, Technical University of Catalonia, Avda Diagonal 647, 08028-Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Navarro
authors.forename: M P
authors.initials: MP
authors.lastname: Ginebra
authors.forename: J A
authors.initials: JA
authors.lastname: Planell
authors.forename: S
authors.initials: S
authors.lastname: Zeppetelli
authors.forename: L
authors.initials: L
authors.lastname: Ambrosio
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000737:chemistry*; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D002460:Cell Line; D002470:Cell Survival; D019245:Compressive Strength; D005549:Foreign-Body Reaction / Q000473:pathology*; D005898:Glass / Q000737:chemistry; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008420:Manufactured Materials / Q000032:analysis; D008422:Materials Testing; D008567:Membranes, Artificial; D010006:Osteoblasts / Q000473:pathology*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); C020243:calcium phosphate