[Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats].
OBJECTIVE
To investigate the therapeutic mechanism of tetromethylpyrazine and aminoguanidine on diabetic nephropathy.


METHODS
Diabetic rats were induced by streptozotocin. They were divided into 5 groups: normal control group (group C), untreated diabetic group (group DM), tetromethylpyrazine treated group (group TMP), aminoguanidine treated group (group AG) and tetromethylpyrazine and aminoguanidine treated group (group TMP+AG). The expression of vascular endothelial growth factor (VEGF) in renal cortex of the rats in each group was observed by immunohistochemical staining after 12 weeks.


RESULTS
The expression of VEGF in renal cortex of the rats in group TMP+AG and group C was alike. The expression of VEGF in renal cortex of group TMP and group AG decreased significantly as compared with that of group C, but was still above normal level.


CONCLUSIONS
The therapeutic mechanism of tetromethylpyrazine and aminoguanidine on diabetic nephropathy may be inhibiting the over-expression of VEGF in kidney of diabetic rats.
Huang
Yan
Y
Department of Anatomy & Histology Fujian Medical University, Fuzhou, Fujian Province 350004, China. hyan88@msn.com
Chen
Shao-Qiang
SQ
Zhang
Geng
G
Chen
Rui-Hua
RH
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis; D006146:Guanidines / Q000494:pharmacology*; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry*; D008297:Male; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*
D006442:Glycated Hemoglobin; D006146:Guanidines; D011719:Pyrazines; D013311:Streptozocin; D042461:Vascular Endothelial Growth Factor A; C004479:pimagedine; C017953:tetramethylpyrazine