title: MAPK signaling: Sho business.
abstract: Sho1 is a membrane protein in yeast that activates the Hog MAPK signaling pathway in response to high osmolarity. An accumulating body of work has focused on Sho1 as a model to better understand the mechanisms that dictate signaling specificity.
authors.affiliation: Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue Room 1081, Toronto, Ontario, Canada.
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Seet
authors.forename: Tony
authors.initials: T
authors.lastname: Pawson
mesh_terms: D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009994:Osmolar Concentration; D011485:Protein Binding; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D015003:Yeasts
chemical_list: D008565:Membrane Proteins; C459787:SHO1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; C089356:PBS2 protein, S cerevisiae