[Effect of Jianwei Yuyang Granules on expression of epidermal growth factor receptor in gastric mucosa of gastric ulcer patients].
OBJECTIVE
To observe the effect of Jianwei Yuyang Granules on the expression of epidermal growth factor receptor (EGFR) in the gastric mucosa of gastric ulcer patients.


METHODS
Sixty gastric ulcer patients (final diagnosis by gastroscope) were randomly divided into Jianwei Yuyang Granules treated group (JWYY group, n=30) and western medicine treated group (control group, n=30). Ten patients without gastric mucosa lesion were treated as normal control group. The expression of EGFR in the mucosa was tested by immunohistochemistry and RT-PCR.


RESULTS
Expression of EGFR and EGFR mRNA was not observed in patients without gastric mucosa lesion, and slight expression was observed in the edge of ulcer region of the gastric ulcer patients. The expression of EGFR and EGFR mRNA was increased in JWYY group and control group.


CONCLUSIONS
Jianwei Yuyang Granules enhances the expression of EGFR in the mucosa of gastric ulcer patients to prevent peptic ulcer recurrence.
Zhang
Wei-Ning
WN
Department of Internal Medicine, Futian District Hospital of Traditional Chinese Medicine,Shenzhen  Guangdong Province 518034, China.
Zhang
Ye
Y
Li
Jia-Bang
JB
D000328:Adult; D066246:ErbB Receptors / Q000032:analysis* / Q000235:genetics; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism
D012333:RNA, Messenger; D066246:ErbB Receptors