title: Increased prothrombin time and platelet counts in living donor right hepatectomy: implications for epidural anesthesia.
abstract: The risks and benefits of adult-to-adult living donor liver transplantation need to be carefully evaluated. Anesthetic management includes postoperative epidural pain relief; however, even patients with a normal preoperative coagulation profile may suffer transient postoperative coagulation derangement. This study explores the possible causes of postoperative coagulation derangement after donor hepatectomy and the possible implications on epidural analgesia. Thirty donors, American Society of Anesthesiology I, with no history of liver disease were considered suitable for the study. A thoracic epidural catheter was inserted before induction and removed when laboratory values were as follows: prothrombin time (PT) > 60%, activated partial thromboplastin time < 1.24 (sec), and platelet count > 100,000 mmf pound sterling (mm3). Standard blood tests were evaluated before surgery, on admission to the recovery room, and daily until postoperative day (POD) 5. The volumes of blood loss and of intraoperative fluids administered were recorded. Coagulation abnormalities observed immediately after surgery may be related mostly to blood loss and to the diluting effect of the intraoperative infused fluids, although the extent of the resection appears to be the most important factor in the extension of the PT observed from POD 1. In conclusion, significant alterations in PT and platelet values were observed in our patients who underwent uncomplicated major liver resection for living donor liver transplantation. Because the potential benefits of epidural analgesia for liver resection are undefined according to available data, additional prospective randomized studies comparing the effectiveness and safety of intravenous versus epidural analgesia in this patient population should be performed.
authors.affiliation: Division of Anesthesiology, University of Modena and Reggio Emilia, Modena, Italy. sinianest@libero.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Siniscalchi
authors.forename: Bruno
authors.initials: B
authors.lastname: Begliomini
authors.forename: Lesley
authors.initials: L
authors.lastname: De Pietri
authors.forename: Vanessa
authors.initials: V
authors.lastname: Braglia
authors.forename: Matteo
authors.initials: M
authors.lastname: Gazzi
authors.forename: Michele
authors.initials: M
authors.lastname: Masetti
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Di Benedetto
authors.forename: Antonio D
authors.initials: AD
authors.lastname: Pinna
authors.forename: Charles M
authors.initials: CM
authors.lastname: Miller
authors.forename: Alberto
authors.initials: A
authors.lastname: Pasetto
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D001778:Blood Coagulation Disorders / Q000209:etiology*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D016014:Linear Models; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control; D010976:Platelet Count; D011184:Postoperative Period; D011517:Prothrombin Time