title: Comparison of long-term usefulness of clopidogrel therapy after the first percutaneous coronary intervention or coronary artery bypass grafting versus that after the second or repeat intervention.
abstract: Patients in the Clopidogrel for the Reduction of Events During Observation trial were subgrouped according to whether they underwent index percutaneous coronary artery revascularization procedures only or this procedure plus subsequent percutaneous or surgical revascularization procedures during 1-year follow-up. The relative risk reduction in ischemic events associated with up-front and long-term clopidogrel compared with placebo was 2-fold greater in patients who required repeat revascularization procedures compared with those who did not (42.4% vs 21.7%).
authors.affiliation: Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Saw
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Topol
authors.forename: Steven R
authors.initials: SR
authors.lastname: Steinhubl
authors.forename: Danielle
authors.initials: D
authors.lastname: Brennan
authors.forename: Peter B
authors.initials: PB
authors.lastname: Berger
authors.forename: David J
authors.initials: DJ
authors.lastname: Moliterno
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D000077144:Clopidogrel; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012086:Reoperation; D040242:Risk Reduction Behavior; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine