[Effects of Xinmailong  Xiangdan and Shenmai Injection on early kidney damage induced by toxin of grass carp bile].
OBJECTIVE
To observe the effects of Xinmailong (XML), Xiangdan (XD) and Shenmai (SM) Injection on early kidney damage induced by toxin of grass carp bile (GCB) and provide experimental evidence for Chinese medicine in treating toxication of GCB.


METHODS
GCB (6ml/kg) was administered orally to adult SD rats to induce the model of GCB intoxication and a single intraperitoneal injection of XML, XD or SM was administered 10 min later.


RESULTS
It was found that the levels of blood creatinine and blood urea nitrogen were decreased and the creatinine clearance rate was increased by XML, XD or SM. Degenerated epithelial cells of proximal convoluted tubules and glomeruli containing red blood cells in saccular cavities were decreased as compared with the normal group (P<0.01).


CONCLUSIONS
The Chinese medicine XML, XD and SM Injection have therapeutic effects on early kidney damage induced by toxin of GCB.
Wu
Jian-Xin
JX
Department of Physiology and Pathophysiology, Dali College, Dali, Yunnan Province 671000, China.
Nui
Rong-Xiang
RX
Dong
Cong-Li
CL
D000818:Animals; D001646:Bile; D002347:Carps; D005260:Female; D007267:Injections; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008516:Medicine, Chinese Traditional; D051381:Rats; D017207:Rats, Sprague-Dawley