[Oxcarbazepine and DRESS syndrome: a paediatric cause of acute liver failure].
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, also called hypersensitivity reaction, is a severe idiosyncratic reaction to drugs, especially to anti-epileptic drugs. Clinical features associate cutaneous eruption, fever, multiple peripheral ganglions, and potentially life-threatening damage of one or more organs. DRESS syndrome is well described in adults treated with aromatic anti-epileptic drugs, such as phenytoin, phenobarbital, and carbamazepine, but also with other drugs. The new anti-epileptic drugs, such as oxcarbazepine also induce various cutaneous eruptions, but with less report of DRESS syndrome. In children, DRESS syndrome is rare and probably underdiagnosed. We report on the case of a 11-year-old girl hospitalised with an acute severe hepatitis revealing an oxcarbazepine-induced DRESS syndrome.
Bosdure
E
E
Service de pédiatrie multidisciplinaire, hôpital Timone-enfant, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
Cano
A
A
Roquelaure
B
B
Reynaud
R
R
Boyer
M
M
Viard
L
L
Sarles
J
J
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D002648:Child; D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D000078330:Oxcarbazepine; D013577:Syndrome
D000927:Anticonvulsants; D002220:Carbamazepine; D000078330:Oxcarbazepine