title: Solid-phase convergent synthesis of a benzimidazolone library via the combination of two smaller arrays of carboxylic acids and secondary amines.
abstract: The concept of convergent synthesis can be extended to combinatorial chemistry in order to obtain collections of products characterized by considerable chemical diversity and a certain molecular complexity. In this work, a library consisting of three carboxylic acids containing a benzimidazolonic functionality with variations at two positions was synthesized on solid phase. After cleavage, this library was combined with a second library consisting of 16 solid-supported amines containing two points of variation. IRORI technology was used for the split-and-mix synthesis of the final 48 members library.
authors.affiliation: NiKem Research, via Zambeletti 25, 20021 Baranzate di Bollate, Milan, Italy.
authors.forename: Ivana
authors.initials: I
authors.lastname: Bianchi
authors.forename: Elena
authors.initials: E
authors.lastname: La Porta
authors.forename: Daniela
authors.initials: D
authors.lastname: Barlocco
authors.forename: Luca F
authors.initials: LF
authors.lastname: Raveglia