IGF-I receptor, cell-cell adhesion, tumour development and progression.
The insulin-like growth factor I receptor (IGF-IR) has been implicated in the development and progression of many common cancers and other neoplastic diseases. The tumorigenic potential of IGF-IR relies on its antiapoptotic and transforming activities. The molecular mechanisms by which IGF-IR controls the proliferation and survival of tumour cells have been extensively studied and many pathways have been delineated. However, the role of IGF-IR in the regulation of non-mitogenic cell functions is less well understood. Here we focus on IGF-IR-dependent cell-cell adhesion. Limited studies suggested that IGF-IR can regulate cell aggregation and intercellular adhesion mediated by cadherins and cadherin-associated proteins. We review the mechanisms of this process and discuss the impact of IGF-IR-dependent cell-cell adhesion on the phenotype of tumour cells.
Mauro
Loredana
L
Department of Cellular Biology and Faculty of Pharmacy, University of Calabria, 87030 Rende, Italy.
Surmacz
Eva
E
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002468:Cell Physiological Phenomena; D003598:Cytoskeletal Proteins / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D051178:alpha Catenin
C495273:CTNNA1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D051178:alpha Catenin; D017526:Receptor, IGF Type 1