title: Selective antegrade cerebral perfusion attenuates brain metabolic deficit in aortic arch surgery: a prospective randomized trial.
abstract: BACKGROUND
  Aortic arch surgery has a high incidence of brain injury. This may in part be caused by a cerebral metabolic deficit observed after hypothermic circulatory arrest (HCA). We hypothesized that selective antegrade cerebral perfusion (SACP) would attenuate this phenomenon.
  
  
  RESULTS
  In a prospective randomized trial, 42 adult patients were allocated to either HCA (22) or SACP. HCA occurred at a nasopharyngeal temperature of 15 degrees C and SACP at a corporeal temperature of 25 degrees C with cerebral perfusion at 15 degrees C. Paired arterial and jugular venous samples were taken before and after arrest. Continuous transcranial Doppler monitoring of middle cerebral artery velocity (MCAV) was performed. Neuropsychometric testing was performed preoperatively and at 6 and 12 weeks postoperatively. There were 3 hospital deaths (7.1%), 2 strokes (4.8%), and 6 episodes of transient neurological deficit (14.3%). From before to after arrest, jugular bulb pO2 changed by -21.67 mm Hg (26.4) in the HCA group versus +2.27 mm Hg (18.8) in the SACP group (P=0.007). Oxygen extraction changed by +1.7 mL/dL (1.3) in the HCA group versus -1 mL/dL (2.4) in the SACP group (P<0.001). MCAV increased by 6.25 cm/s (9.1) in the HCA group and 19.2 cm/s (10.1) in the SACP group (P=0.001). Incidence of neuropsychometric deficit at 6 weeks was 6/12 (50%) in HCA patients and 8/10 (80%) in SACP patients (P=0.2), and at 12 weeks was 6/16 (38%) in HCA patients and 4/11 (36%) in SACP patients (P=1).
  
  
  CONCLUSIONS
  SACP attenuates the metabolic changes seen after HCA. Further studies are required to assess optimal perfusion conditions and clinical outcome.
authors.affiliation: Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, UK.
authors.forename: D K
authors.initials: DK
authors.lastname: Harrington
authors.forename: A S
authors.initials: AS
authors.lastname: Walker
authors.forename: H
authors.initials: H
authors.lastname: Kaukuntla
authors.forename: R M
authors.initials: RM
authors.lastname: Bracewell
authors.forename: T H
authors.initials: TH
authors.lastname: Clutton-Brock
authors.forename: M
authors.initials: M
authors.lastname: Faroqui
authors.forename: D
authors.initials: D
authors.lastname: Pagano
authors.forename: R S
authors.initials: RS
authors.lastname: Bonser
mesh_terms: D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000601:surgery; D001013:Aorta, Thoracic / Q000601:surgery*; D001014:Aortic Aneurysm / Q000601:surgery; D001783:Blood Flow Velocity; D001925:Brain Damage, Chronic / Q000209:etiology / Q000517:prevention & control; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects; D006400:Hematocrit; D017052:Hospital Mortality; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects; D002534:Hypoxia, Brain / Q000209:etiology / Q000517:prevention & control*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010477:Perfusion / Q000379:methods*; D011446:Prospective Studies; D020521:Stroke / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen