title: Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.
abstract: A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.
authors.affiliation: Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, 1 Drexel Drive, New Orleans 70125, USA.
authors.forename: Jean Jacques
authors.initials: JJ
authors.lastname: Vanden Eynde
authors.forename: Annie
authors.initials: A
authors.lastname: Mayence
authors.forename: Tien L
authors.initials: TL
authors.lastname: Huang
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Collins
authors.forename: Sandra
authors.initials: S
authors.lastname: Rebholz
authors.forename: Peter D
authors.initials: PD
authors.lastname: Walzer
authors.forename: Melanie T
authors.initials: MT
authors.lastname: Cushion
mesh_terms: D000818:Animals; D001550:Benzamidines / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D045363:Pneumocystis carinii / Q000187:drug effects* / Q000254:growth & development; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D051381:Rats; D011914:Rats, Inbred BN; D020318:Rats, Long-Evans
chemical_list: D001550:Benzamidines