[Autologous chondrocyte transplantation for the treatment of articular cartilage defects inf the knee joint. Techniques and results].
BACKGROUND
Currently the use of autologous chondrocytes as a cartilage-repair procedure for the repair of injured articular cartilage of the knee joint, is recommended.


METHODS
This review presents the technique of autologous chondrocyte transplantation (ACT) and their modifications as matrix-associated autologous chondrocyte transplantation (MACT). Beside the surgical procedure the experimental and clinical results are discussed. Furthermore the major complications and the indication guidelines are presented.


RESULTS
Articular cartilage in adults has a poor ability to self-repair after a substantial injury. Surgical therapeutic efforts in treating cartilage defects have focused on bringing new cells capable of chondrogenesis into the lesions. With ACT good to excellent clinical results are seen in isolated posttraumatic lesions of the knee joint in the younger patient with the formation of hyaline-like repair tissue. The major complications are periosteal hypertrophy, delamination of the transplant, arthrofibrosis and transplant failure. The current limitations include osteoarthritic defects and higher patient age.


CONCLUSIONS
With the right indication and operative technique ACT is an effective and save option for the treatment of large full thickness cartilage defect of the knee joint.
Marlovits
S
S
Universitätsklinik für Unfallchirurgie, Medizinische Universität Wien. stefan.marlovits@akh-wien.ac.at
Kutscha-Lissberg
F
F
Aldrian
S
S
Resinger
C
C
Singer
P
P
Zeller
P
P
Vécsei
V
V
D002357:Cartilage Diseases / Q000209:etiology / Q000517:prevention & control; D002358:Cartilage, Articular / Q000293:injuries* / Q000601:surgery*; D017690:Cell Transplantation / Q000009:adverse effects / Q000379:methods; D019902:Chondrocytes / Q000637:transplantation*; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D019637:Orthopedic Procedures / Q000379:methods*; D018579:Patient Selection; D016896:Treatment Outcome