title: Study on intraluminal embolization with microcoils treating traumatic pseudoaneurysms in common carotid artery in rabbits.
abstract: OBJECTIVE
  To evaluate the long-term effect of endovascular occlusion with microcoils on traumatic pseudoaneurysms (TPAs) in the common carotid artery in rabbits.
  
  
  METHODS
  TPAs in the right common carotid artery were surgically made in 16 rabbits. At 3-4 weeks after operation, the survived 12 models were randomly divided into a control group (n=3) with no treatment and an experimental group (n=9), in which TPAs were intraluminally embolized with microcoils and corresponding therapy was given. Three months after embolization, the TPAs were examined with digital subtraction angiography and pathology.
  
  
  RESULTS
  The 3 rabbits in the control group all died of rupture of TPA. Among the 9 TPAs occluded with microcoils, 4 were completely occluded, 4 were partially occluded, and 1 was excluded due to the microcoils migrating into the parent artery. Three months after embolization, the 4 TPAs which were completely occluded remained obliterated as determined by digital subtraction angiographic findings. The parent artery remained unobstructed and the structure of the TPAs were replaced by a mass of scar tissues. The 4 TPAs which were partially occluded remained unruptured and the microcoils were compressed.
  
  
  CONCLUSIONS
  The lumen in TPA can be completely occluded by microcoils and the parent artery is unblocked. Partial occlusion of the lumen can also prevent the rupture of TPA.
authors.affiliation: Department of Emergency, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China. liuys_888@sohu.com
authors.forename: Yun-Song
authors.initials: YS
authors.lastname: Liu
authors.forename: Lian-Ting
authors.initials: LT
authors.lastname: Ma
authors.forename: Zuo-Quan
authors.initials: ZQ
authors.lastname: Wu
mesh_terms: D017541:Aneurysm, False / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D000792:Angiography; D000818:Animals; D001707:Biopsy, Needle; D017536:Carotid Artery, Common / Q000473:pathology*; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D011336:Probability; D011817:Rabbits; D011897:Random Allocation; D012680:Sensitivity and Specificity