title: [Pathogenic mechanisms of autoimmune diseases].
abstract: BACKGROUND
  Auto-immune diseases are a fascinating but poorly understood group of diseases.
  
  
  RESULTS
  In this review, we will consider genetic susceptibility to auto-immune diseases, initiation of autoreactivity and changes in pathologic processes. Recent physiopathological hypotheses are detailed with clinical examples.
  
  
  CONCLUSIONS
  A better knowledge of the physiopathological mechanisms would allow the development of more efficacious treatments.
authors.affiliation: Inserm U517, faculté de médecine, service d'immunologie clinique et de médecine interne, centre hospitalo-universitaire du Bocage, Dijon, France. bernard.bonnotte@chu-dijon.fr
authors.forename: B
authors.initials: B
authors.lastname: Bonnotte
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007108:Immune Tolerance; D007136:Immunoglobulins / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007136:Immunoglobulins; D003165:Complement System Proteins