title: Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome.
abstract: The mechanism of orthodeoxia (OD), or decreased partial pressure of arterial oxygen (PaO2) from supine to upright, a characteristic feature of hepatopulmonary syndrome (HPS), has never been comprehensively elucidated. We therefore investigated the intrapulmonary (shunt and ventilation-perfusion [VA/Q] mismatching) and extrapulmonary factors governing PaO2 in 20 patients with mild to severe HPS (14 males, 6 females; 50 +/- 3 years old SE) at upright and supine, in random order. We set out a cutoff value for OD, namely a PaO2 decrease > or = 5% or > or = 4 mm Hg (area under the receiver operating characteristic curve, 0.96 each). Compared to supine, 5 patients showed OD (PaO2 change, -11% +/- 2%, -7 +/- 1 mm Hg, P < .05) with further VA/Q worsening (shunt + low VA/Q mode increased from 19% +/- 7% to 21% +/- 7% of cardiac output [QT], P < .05), as opposed to 15 patients who did not (+2% +/- 2%, +1+/- 1 mm Hg) with VA/Q improvement (from 20% +/- 4% to 16% +/- 4% of QT, P < .01). Cardiac output was significantly lower in OD patients in both positions. Changes in extrapulmonary factors at upright, such as increased minute ventilation and decreased QT, were of similar magnitude in both subsets of patients. In conclusion, our data suggest that gas exchange response to OD in HPS points to a more altered pulmonary vascular tone inducing heterogeneous blood flow redistribution to lung zones with prominent intrapulmonary vascular dilatations.
authors.affiliation: Serveis de Pneumologia, Anestesiologia i Hepatologia, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Federico P
authors.initials: FP
authors.lastname: Gómez
authors.forename: Graciela
authors.initials: G
authors.lastname: Martínez-Pallí
authors.forename: Joan A
authors.initials: JA
authors.lastname: Barberà
authors.forename: Josep
authors.initials: J
authors.lastname: Roca
authors.forename: Miquel
authors.initials: M
authors.lastname: Navasa
authors.forename: Robert
authors.initials: R
authors.lastname: Rodríguez-Roisin
mesh_terms: D000328:Adult; D005260:Female; D020065:Hepatopulmonary Syndrome / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology*; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange; D014655:Vascular Resistance; D014692:Ventilation-Perfusion Ratio