title: Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity.
abstract: New pyrrolobenzodiazepine-anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines
authors.affiliation: Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: R
authors.initials: R
authors.lastname: Ramu
authors.forename: G B Ramesh
authors.initials: GB
authors.lastname: Khanna
authors.forename: Ajit Kumar
authors.initials: AK
authors.lastname: Saxena
authors.forename: M
authors.initials: M
authors.lastname: Shanmugavel
authors.forename: Renu Moti
authors.initials: RM
authors.lastname: Pandita
mesh_terms: D000880:Anthraquinones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D011758:Pyrroles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D011758:Pyrroles; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; D001569:Benzodiazepines; D004247:DNA