title: Biomaterial challenges and approaches to stem cell use in bone reconstructive surgery.
abstract: As life expectancy increases, so does the need to treat large bone defects. New biomaterials combined with osteogenic cells are now being developed as an alternative to autogenous bone grafts. The goal is to make the stem cells adhere to the scaffold, and then grow to differentiate into functional osteogenic cells and organize into healthy bone as the scaffold degrades. Decisive improvements have been made in the fields of stem cell biology, 3-D scaffold fabrication and tissue engineering, but the ideal bone substitute that fulfils all functional and safety requirements has yet to be developed.
authors.affiliation: LR2B, Université du Littoral Côte d'Opale, INSERM ERI 002, 52 Rue du Docteur Calot, 62608 Berck, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Olivier
authors.forename: Nathalie
authors.initials: N
authors.lastname: Faucheux
authors.forename: Pierre
authors.initials: P
authors.lastname: Hardouin
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods; D001842:Bone and Bones / Q000166:cytology / Q000601:surgery; D006801:Humans; D019651:Plastic Surgery Procedures / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000166:cytology*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes