Severe factor X deficiency in pregnancy: case report and review of the literature.
Isolate factor X deficiency is an extremely rare clotting factor disorder inherited in autosomal recessive fashion and pregnancy in a homozygous patient is frequently complicated by recurrent miscarriage, uterine bleeding and premature labour. Eleven pregnancies in seven patients affected by FX deficiency have been reported in the literature. Two additional pregnancies have been reported in a FX variant (FX Friuli). We present a new case of successful at term pregnancy in a homozygous patient.
Romagnolo
C
C
Obstetric Gynecology Department, Sacro Cuore Hospital Negrar, Verona, Italy. cesare.romagnolo@sacrocuore.it
Burati
S
S
Ciaffoni
S
S
Fattori
E
E
Franchi
M
M
Zanon
E
E
Girolami
A
A
D000328:Adult; D002585:Cesarean Section; D005171:Factor X Deficiency / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000517:prevention & control; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D011256:Pregnancy Outcome; D011516:Prothrombin / Q000627:therapeutic use
D011516:Prothrombin