title: Effect of a lipid pool on stress/strain distributions in stenotic arteries: 3-D fluid-structure interactions (FSI) models.
abstract: Nonlinear 3-D models with fluid-structure interactions (FSI) based on in vitro experiments are introduced and solved by ADINA to perform flow and stress/strain analysis for stenotic arteries with lipid cores. Navier-Stokes equations are used as the governing equations for the fluid. Hyperelastic Mooney-Rivlin models are used for both the arteries and lipid cores. Our results indicate that critical plaque stress/strain conditions are affected considerably by stenosis severity, eccentricity, lipid pool size, shape and position, plaque cap thickness, axial stretch, pressure, and fluid-structure interactions, and may be used for possible plaque rupture predictions.
authors.affiliation: Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA. dtang@wpi.edu
authors.forename: Dalin
authors.initials: D
authors.lastname: Tang
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Shunichi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: David N
authors.initials: DN
authors.lastname: Ku
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001790:Blood Physiological Phenomena; D001794:Blood Pressure; D002339:Carotid Arteries / Q000502:physiology*; D016893:Carotid Stenosis / Q000503:physiopathology*; D002417:Cattle; D003198:Computer Simulation; D003251:Constriction, Pathologic / Q000503:physiopathology; D004548:Elasticity; D018056:Hemorheology / Q000379:methods*; D006801:Humans; D050356:Lipid Metabolism; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical