The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells.
Three water-soluble carboxy nitroxide antioxidants, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl, 4-carboxy-2,2,6,6-tetramethylpiperidin-1-yloxyl, and 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl, show significant impact on the postirradiation survival rates of ataxia telangiectasia (A-T) cells compared to normal cells, an assay which represents a model for understanding the impact of ROS damage on the A-T phenotype. The effects of these antioxidants are much more significant than those of vitamin E or Trolox (a water-soluble vitamin E analog), studied using the same cell survival model.
Hosokawa
Kazuyuki
K
Science Research Centre, Faculty of Science, Queensland University of Technology, Brisbane, QLD 4001, Australia.
Chen
Philip
P
Lavin
F Martin
FM
Bottle
E Steven
ES
D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001260:Ataxia Telangiectasia / Q000378:metabolism* / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D003497:Cyclic N-Oxides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology*
C499782:3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl; C499783:5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl acetoxymethyl ester; D000975:Antioxidants; D003497:Cyclic N-Oxides; D007211:Indoles; D011759:Pyrrolidines; C048737:tempo carboxylic acid