title: [The value of applying nitroglycerin in 3D coronary MR angiographie with real-time navigation technique].
abstract: OBJECTIVE
  Nitroglycerin administration results in dilation of epicardial coronary vessels and in an increase in coronary blood flow, and has been suggested to improve MR coronary angiography. This study evaluates systematically whether administration of nitroglycerin improves the visualization of coronary arteries and, as a result, the detection of coronary artery stenosis during free breathing 3D coronary MR angiography.
  
  
  METHODS
  Coronary MR angiography was performed in 44 patients with suspected coronary artery disease at a 1.5 Tesla System (Intera, Philips Medical Systems) (a) with and (b) without continuous administration of intravenous nitroglycerin at a dose rate of 2.5 mg/h, using an ECG gated gradient echo sequence with real-time navigator correction (turbo field echo, in-plane resolution 0.70 x 0.79 mm(2), acquisition window 80 ms). Equivalent segments of the coronary arteries in the sequences with and without nitroglycerin were evaluated for visualized vessel length and diameter, qualitative assessment of visualization using a four point grading scale and detection of stenoses > 50 %. Catheter coronary angiography was used as a gold-standard.
  
  
  RESULTS
  No significant differences were found between scans with and without nitroglycerin as to average length of the contiguously visualized vessel length (p > 0.05) and diameter (p > 0.05). There was also no significant difference in the coronary MR angiography with and without nitroglycerin in the average qualitative assessment score of the visualization of LM, proximal LAD, proximal CX, and proximal and distal RCA (2.1 +/- 0.8 and 2.2 +/- 0.7; p > 0.05). Sensitivity (77 % [17/22] vs. 82 % [18/22] p > 0.05) and specificity (72 % [13/18] vs. 72 % [13/18] p > 0.05) for the detection of coronary artery stenosis also did not differ significantly between scans with and without intravenous administration of nitroglycerin.
  
  
  CONCLUSIONS
  Administration of nitroglycerin does not improve visualization of the coronary arteries and detection of coronary artery stenosis in free breathing 3D coronary MR angiography.
authors.affiliation: Radiologische Universitätsklinik Bonn. matthias.hackenbroch@ukb.uni-bonn.de
authors.forename: M
authors.initials: M
authors.lastname: Hackenbroch
authors.forename: C
authors.initials: C
authors.lastname: Meyer
authors.forename: A
authors.initials: A
authors.lastname: Schmiedel
authors.forename: U
authors.initials: U
authors.lastname: Hofer
authors.forename: S
authors.initials: S
authors.lastname: Flacke
authors.forename: A
authors.initials: A
authors.lastname: Kovács
authors.forename: K
authors.initials: K
authors.lastname: Tiemann
authors.forename: D
authors.initials: D
authors.lastname: Skowasch
authors.forename: H
authors.initials: H
authors.lastname: Schild
authors.forename: T
authors.initials: T
authors.lastname: Sommer
mesh_terms: D017023:Coronary Angiography / Q000379:methods*; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D005996:Nitroglycerin / Q000008:administration & dosage; D012680:Sensitivity and Specificity; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin