title: Influence of octacalcium phosphate coating on osteoinductive properties of biomaterials.
abstract: In this study, we investigated the influence of octacalcium phosphate (OCP) coating on osteoinductive behaviour of the biomaterials. Porous titanium alloy (Ti6Al4V), hydroxyapatite (HA), biphasic calcium phosphate (BCP) and polyethylene glyco terephtalate/polybuthylene terephtalate (PEGT-PBT) copolymer, all uncoated and coated with biomimetically produced OCP, were implanted in back muscles of 10 goats for 6 and 12 weeks. Uncoated Ti6Al4Vand HA did not show any bone formation after intramuscular implantation. All OCP coated implants, except PEGT-PBT, did induce bone in the soft tissue. The reason for the non-inductive behaviour of the copolymer is probably its softness, that makes it impossible to maintain its porous shape after implantation. Both uncoated and OCP coated BCP induced bone. However, the amount of animals in which the bone was induced was higher in the coated BCP implants in comparison to the uncoated ones. Osteoinductive potential of biomaterials is influenced by various material characteristics, such as chemical composition, crystallinity, macro- and microstructure. OCP coating has a positive effect on osteoinductivity of the biomaterials. The combination of the advantages of biomimetic coating method above traditional methods, and a good osteoinductivity of OCP coating that is produced by using this method, opens new possibilities for designing more advanced orthopaedic implants.
authors.affiliation: Institute of Biomedical Technology, Twente University, Department Bilthoven, Professor Bronkhorstlaan 10-D, 3723 MB, Bilthoven, The Netherlands. Pamela.habibovic@isotis.com
authors.forename: P
authors.initials: P
authors.lastname: Habibovic
authors.forename: C M
authors.initials: CM
authors.lastname: van der Valk
authors.forename: C A
authors.initials: CA
authors.lastname: van Blitterswijk
authors.forename: K
authors.initials: K
authors.lastname: De Groot
authors.forename: G
authors.initials: G
authors.lastname: Meijer
mesh_terms: D000497:Alloys; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D001846:Bone Development / Q000502:physiology; D001842:Bone and Bones / Q000166:cytology; D002130:Calcium Phosphates / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D006041:Goats; D008422:Materials Testing; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology / Q000601:surgery; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D011092:Polyethylene Glycols / Q000737:chemistry; D011093:Polyethylene Terephthalates / Q000031:analogs & derivatives / Q000737:chemistry; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D011093:Polyethylene Terephthalates; C475920:polyethylene terephthalate glycol; C031462:titanium alloy (TiAl6V4); C022045:octacalcium phosphate; D011092:Polyethylene Glycols; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium