Human-Mouse Gene Searcher: a tool to assist discovery of malformation-associated genes by using phenotype databases.
An open-access World Wide Web application has been developed which enables the cross-linking of anatomical data on the phenotypic manifestations of human and mouse malformation syndromes to data on gene function and/or expression patterns in the mouse GXD database. Ultimately, the system has been designed to assist biologists in the process of discovering hitherto unidentified malformation genes. More specifically, it facilitates search from the phenotypic level.


BACKGROUND
The application and further information is available at http://genetics.ich.ucl.ac.uk/linksearchtool.
Bradford
Ian
I
Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. i.bradford@ich.ucl.ac.uk
Winter
Robin
R
Evans
Carl
C
Bard
Jonathan
J
D000818:Animals; D003196:Computer Graphics; D000013:Congenital Abnormalities / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods*; D003628:Database Management Systems; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D051379:Mice; D010641:Phenotype; D012984:Software; D014584:User-Computer Interface