The randomized trials of breast cancer screening: what have we learned?
Eight randomized controlled trials of mammography screening have been conducted to date. In addition to evaluating the efficacy of screening with an experimental design, the trials provided investigators with access to information about breast cancers much earlier in their development than had previously been available. The trials of mammographic screening provide conclusive evidence that the policy of offering screening is associated with a significant and substantial reduction in breast cancer mortality.
Smith
Robert A
RA
American Cancer Society, 1599 Clifton Road, NE, Atlanta, GA 30329, USA. robert.smith@cancer.org
Duffy
Stephen W
SW
Gabe
Rhian
R
Tabar
Laszlo
L
Yen
Amy M F
AM
Chen
Tony H H
TH
D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality; D005260:Female; D006801:Humans; D008327:Mammography; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity; D015996:Survival Rate