[Immune response to the oral administration of a new meningococcal preparation, serogroup A, under experiment].
In the experiment on rabbits immune response to the oral administration of a new Neisseria meningitidis whole culture preparation, serogroup A, was demonstrated. The preparation was based on the acetone fixed culture, grown by the continuous flow method under a computer-controlled constant level of oxygen. The immunological activity of the preparation was demonstrated. In the blood sera of rabbits examined by immunoenzyme assay and the passive hemagglutination test, a multiple increase in the content of hemagglutinating and IgG antibodies to polysaccharide, outer membrane proteins and lipooligosaccharide was noted, their content remaining at a high level for 303 days (the term of observation). The oral immunization with the preparation protected mice infected with N. meningitidis live culture, serogroup A.
Aleksakhina
N N
NN
Basnak'ian
I A
IA
Kozlova
N N
NN
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D006386:Hemagglutination Tests; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology; D008589:Meningococcal Infections / Q000097:blood / Q000517:prevention & control*; D051379:Mice; D038381:Neisseria meningitidis, Serogroup A / Q000276:immunology / Q000302:isolation & purification; D011134:Polysaccharides / Q000276:immunology; D011817:Rabbits; D013997:Time Factors; D014611:Vaccination
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; D011134:Polysaccharides; C023023:lipid-linked oligosaccharides