NCD3G: a novel nine-cysteine domain in family 3 GPCRs.
The NCD3G [for nine-cysteine domain of family 3 G-protein-coupled receptors (GPCRs)] domain is a novel protein domain that is conserved in family 3 GPCRs, including metabotropic glutamate receptors, calcium-sensing receptors, pheromone receptors and taste receptors, with the exception of GABA(B) receptors. The NCD3G domain contains nine highly conserved cysteine residues. Structural predictions suggest that NCD3G might possess four beta strands and three disulfide bridges. The structural model of NCD3G highlights the conserved residues co-segregated with certain familial diseases.
Liu
Xianghua
X
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Handan Road 220, Shanghai 200433, P.R. China.
He
Quanyuan
Q
Studholme
David J
DJ
Wu
Qi
Q
Liang
Songping
S
Yu
Long
L
D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D003553:Cystine; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000502:physiology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D043562:Receptors, G-Protein-Coupled; D003553:Cystine