Diastereoselective dihydroxylation and regioselective deoxygenation of dihydropyranones: a novel protocol for the stereoselective synthesis of C1-C8 and C15-C21 subunits of (+)-discodermolide.
Diastereoselective dihydroxylation of dihydropyranones and subsequent regioselective alpha-deoxygenation provides 1,3-trans-beta-hydroxy-delta-lactones stereoselectively. This protocol has been applied for the synthesis of C(1)-C(8) and C(15)-C(21) subunits of (+)-discodermolide.
Ramachandran
P Veeraraghavan
PV
Herbert C. Brown Center for Borane Research, 560 Oval Drive, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, USA. chandran@purdue.edu
Prabhudas
Bodhuri
B
Chandra
J Subash
JS
Reddy
M Venkat Ram
MV