[Role of polymorphic adhesion molecules in the development of graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation].
Mismatches of minor histocompatibility antigens (mHas) between HLA-identical stem cell donors and recipients are known as a major risk factor for graft-versus-host disease (GVHD). We determined the alleles of 5 polymorphic molecules including HA-1 and 4 adhesion molecules in 102 patients who had undergone stem cell transplantation from HLA-identical donors and investigated the association of their mismatches with the relapse rate and incidence of GVHD. We observed relapse rates of 16.1% in patients with at least one or more incompatibilities and 39.4% in patients without incompatibilities (p = 0.018). The respective relapse rates of patients with CD62L, HA-1, CD31 exon 563, CD31 exon 125 and 49b incompatibilities were 6.1%, 14.3%, 11.7%, 20% and 40%. Only patients with CD62L incompatibilities showed a lower relapse rate than patients who received a compatible graft. Since there was no difference between patients with and without incompatibilities as far as the appearance of acute GVHD (> or = 2) was concerned, we conclude that the polymorphic CD62L molecule contributes to graft-versus-leukemia rather than the development of GVHD after HLA-identical stem cell transplantation.
Shiobara
Shintaro
S
Division of Transfusion Medicine, Kanazawa University Hospital.
Sato
Hidehiro
H
Furukawa
Tastuo
T
Tsukada
Jyunichi
J
Yasue
Shizuka
S
Takeda
Hiroko
H
Togawa
Akiko
A
Taira
Masumi
M
Sakai
Yoshiko
Y
Aizawa
Yoshifusa
Y
Nakao
Shinnji
S
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D020544:Graft vs Leukemia Effect; D006680:HLA Antigens; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D019041:L-Selectin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D009842:Oligopeptides; D011110:Polymorphism, Genetic; D014184:Transplantation, Homologous
C110615:HA-1 antigen; D006680:HLA Antigens; D015778:Minor Histocompatibility Antigens; D009842:Oligopeptides; D019041:L-Selectin