Lipid phase perturbations and the unfolded protein response.
Recent studies of the consequences of ganglioside accumulation in lysosomal storage disease and free cholesterol accumulation in cell membranes in atherosclerosis suggest an unexpected link between perturbation of the endoplasmic reticulum membrane's lipid phase, induction of the unfolded protein response, and cell death.
Ron
David
D
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Oyadomari
Seiichi
S
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D016923:Cell Death; D002462:Cell Membrane / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry*; D011489:Protein Denaturation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
D008055:Lipids; D011506:Proteins