title: A theory of optimal differential gene expression.
abstract: We investigate a model of optimal regulation, intended to describe large-scale differential gene expression. Relations between the optimal expression patterns and the function of genes are deduced from an optimality principle: the regulators have to maximise a fitness function which they influence directly via a cost term, and indirectly via their control on important cell variables, such as metabolic fluxes. According to the model, the optimal linear response to small perturbations reflects the regulators' functions, namely their linear influences on the cell variables. The optimal behaviour can be realised by a linear feedback mechanism. Known or assumed properties of response coefficients lead to predictions about regulation patterns. A symmetry relation predicted for deletion experiments is verified with gene expression data. Where the optimality assumption is valid, our results justify the use of expression data for functional annotation and for pathway reconstruction and suggest the use of linear factor models for the analysis of gene expression data.
authors.affiliation: Berlin Center for Genome Based Bioinformatics, Max Planck Institute for Molecular Genetics, Berlin, Germany. lieberme@molgen.mpg.de
authors.forename: Wolfram
authors.initials: W
authors.lastname: Liebermeister
authors.forename: Edda
authors.initials: E
authors.lastname: Klipp
authors.forename: Stefan
authors.initials: S
authors.lastname: Schuster
authors.forename: Reinhart
authors.initials: R
authors.lastname: Heinrich
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D002468:Cell Physiological Phenomena; D005246:Feedback / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D005809:Genes, Regulator / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D009097:Multienzyme Complexes / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D009097:Multienzyme Complexes; D014157:Transcription Factors