Development of porous spherical hydroxyapatite granules: application towards protein delivery.
A new method for the preparation of porous spherical hydroxyapatite granules is reported. It may be clinically applied towards orthopaedic or maxillofacial surgery as fillers or packing materials, and as biological chromatography supports. Its application towards delivery of macromolecules or protein drugs is discussed utilizing human serum albumin (HSA) as a model protein.
Paul
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Division of Biosurface Technology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Biomedical Technology Wing, Trivandrum 695 012, India.
Sharma
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CP