Synthesis of a bis-amino acid that creates a sharp turn.
[reaction: see text] The synthesis of a new bis-amino acid 1 is presented. This monomer is designed to create a tightly curved structure when assembled into oligomers. The monomer is demonstrated to couple to the previously developed monomer 2 through pairs of amide bonds to create a strongly bent spiro-ladder oligomer. The structure of oligomer 3 was determined in aqueous solution using two-dimensional NMR.
Habay
Stephen A
SA
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Schafmeister
Christian E
CE
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011487:Protein Conformation; D013237:Stereoisomerism
D000596:Amino Acids