Long-term bone response to titanium implants coated with thin radiofrequent magnetron-sputtered hydroxyapatite in rabbits.
OBJECTIVE
The present study was designed to investigate the long-term bone response around machined screw-type uncoated and calcium phosphate (CaP) -coated commercially pure titanium implants.


METHODS
Using a magnetron sputtering technique, implants with a CaP coating similar in composition and CaP ratio to hydroxyapatite were produced. Heat treatment was subsequently used to increase the crystallinity of the coatings. Four types of coatings (0.1 and 2.0 microm amorphous and 0.1 and 2.0 microm crystalline) were manufactured; uncoated implants served as a control. Three hundred twenty implants (64 of each type) were randomly placed in the tibial cortical and trabecular femoral bones of 40 rabbits. The rabbits were sacrificed 9 months after implant placement.


RESULTS
Histomorphometric evaluation carried out on ground sections revealed that the crystalline CaP coatings achieved the highest bone-implant contact in both tibiae and femora compared with amorphous CaP-coated and uncoated titanium.


CONCLUSIONS
The present study suggests that submicron crystalline hydroxyapatite coating adds bioactive properties to titanium oral implants.


CONCLUSIONS
An ultra-thin, 0.1-microm crystalline CaP coating can elicit and maintain an improved long-term bone response compared to amorphous coated or uncoated Ti implants, without any adverse tissue reactions.
Mohammadi
Shams
S
Department of Biomaterials, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
Esposito
Marco
M
Hall
Jan
J
Emanuelsson
Lena
L
Krozer
Anatol
A
Thomsen
Peter
P
D000704:Analysis of Variance; D000818:Animals; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D003460:Crystallization; D015921:Dental Implants; D017886:Durapatite; D005260:Female; D005269:Femur; D020007:Implants, Experimental; D016348:Osseointegration; D011817:Rabbits; D013977:Tibia; D014025:Titanium
D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium