Motor and cognitive function evaluation following experimental traumatic brain injury.
Traumatic brain injury (TBI) in humans may cause extensive sensorimotor and cognitive dysfunction. As a result, many TBI researchers are beginning to assess behavioral correlates of histologically determined damage in animal models. Although this is an important step in TBI research, there is a need for standardization between laboratories. The ability to reliably test treatments across laboratories and multiple injury models will close the gap between treatment success in the lab and success in the clinic. The goal of this review is to describe and evaluate the tests employed to assess functional outcome after TBI and to overview aspects of cognitive, sensory, and motor function that may be suitable targets for therapeutic intervention.
Fujimoto
Scott T
ST
Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105C Hayden Hall, Philadelphia, PA 19104-6316, USA.
Longhi
Luca
L
Saatman
Kathryn E
KE
Conte
Valeria
V
Stocchetti
Nino
N
McIntosh
Tracy K
TK
D000818:Animals; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D003943:Diagnostic Techniques, Neurological; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009069:Movement Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D009460:Neurologic Examination / Q000379:methods; D011597:Psychomotor Performance; D051381:Rats; D020127:Recovery of Function; D045442:Rotarod Performance Test; D013028:Space Perception; D013045:Species Specificity; D014724:Vestibular Function Tests / Q000379:methods