title: Usefulness of asialoglycoprotein receptor imaging for the evaluation of liver metastasis of neuroblastoma.
abstract: Neuroblastoma, derived from the neural crest ectoderm, is the most common type of solid abdominal mass seen in infancy. The diagnosis, staging, and follow-up of neuroblastoma are often performed using metaiodobenzylguanidine (MIBG) imaging. However, the evaluation of liver metastasis by this method is complicated by the normal physiological uptake of MIBG by the liver. The asialoglycoprotein receptor is a hepatic cell-surface receptor specific for galactose-terminated glycoprotein, and 99mTc-DTPA-galactosyl human serum albumin (GSA) accumulates selectively in hepatic cells. Here, we report a case of congenital neuroblastoma with liver metastasis in which GSA scans were useful for differentiation between normal and metastatic sites in the liver.
authors.affiliation: Department of Radiology, Graduate School of Medicine, Tohoku University, Japan. kaneta@rad.med.tohoku.ac.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaneta
authors.forename: Takashi
authors.initials: T
authors.lastname: Hakamatsuka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Shin
authors.initials: S
authors.lastname: Maruoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukuda
authors.forename: Shoki
authors.initials: S
authors.lastname: Takahashi
authors.forename: Shogo
authors.initials: S
authors.lastname: Yamada
mesh_terms: D019797:3-Iodobenzylguanidine; D037263:Asialoglycoprotein Receptor / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary*; D008297:Male; D009447:Neuroblastoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
chemical_list: D037263:Asialoglycoprotein Receptor; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D019797:3-Iodobenzylguanidine; D016284:Technetium Tc 99m Pentetate