title: Cortisol resistance in the New World revisited.
abstract: Insights into the molecular basis of glucocorticoid action have been obtained from the analysis of cortisol resistance. The glucocorticoid receptor (GR) in both New World primates and guinea pigs has a decreased affinity, in vivo, for cortisol; this is achieved by two distinct mechanisms. In the New World primates recent studies have identified a key role for co-chaperones. The amino acids responsible for cortisol resistance in the guinea pig GR lie not in the ligand-binding pocket but on the surface of the receptor. We hypothesize that this region might be the site of interaction between the co-chaperones and the GR, and hence that the resistance occurs through the same mechanism, albeit from opposite sides.
authors.affiliation: Prince Henry's Institute of Medical Research, Clayton and Walter and Eliza Hall Institute, Parkville, Victoria, Australia. peter.fuller@phimr.monash.edu.au
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fuller
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Smith
authors.forename: Fraser M
authors.initials: FM
authors.lastname: Rogerson
mesh_terms: D000818:Animals; D002427:Cebidae / Q000502:physiology*; D006168:Guinea Pigs; D018841:HSP90 Heat-Shock Proteins / Q000502:physiology; D006854:Hydrocortisone / Q000502:physiology*; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000502:physiology; D011965:Receptors, Glucocorticoid / Q000737:chemistry / Q000502:physiology; D022021:Tacrolimus Binding Proteins / Q000502:physiology
chemical_list: D018841:HSP90 Heat-Shock Proteins; D018832:Molecular Chaperones; D011965:Receptors, Glucocorticoid; D022021:Tacrolimus Binding Proteins; D006854:Hydrocortisone