The synthesis of unsymmetrically N-substituted chiral 1,4,7-triazacyclononanes.
A number of chiral unsymmetrically N-substituted 1,4,7-triazacyclononane ligands have been prepared by modular methods. The key step in the synthesis centres on the macrocyclisation of three tertiary amide precursors under standard Richman-Atkins conditions which allows for subsequent N-functionalisation.
Scheuermann
J Erik W
JE
Department of Chemistry, Queen Mary, University of London, Mile End Road, London, UK E1 4NS.
Sibbons
Kevin F
KF
Benoit
David M
DM
Motevalli
Majid
M
Watkinson
Michael
M
D002384:Catalysis; D018360:Crystallography, X-Ray; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D010084:Oxidation-Reduction
D006571:Heterocyclic Compounds; D008024:Ligands; C075712:1,4,7-triazacyclononane