title: Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy in high myopia: a prospective clinical study.
abstract: BACKGROUND
  To study the effect of prophylactic application of mitomycin-C on haze formation in photorefractive keratectomy (PRK) for high myopia.
  
  
  METHODS
  Fifty-four eyes of 28 myopic patients were enrolled in this prospective study. All eyes were operated by PRK followed by 0.02% mitomycin-C application for two minutes and washed with 20 ml normal saline afterwards. All eyes were examined thoroughly on the first 7 days and one month after surgery; 48 eyes (88.9%) at 3 and 6 months postoperatively. Hanna grading (in the scale of 0 to 4+) was used for assessment of corneal haze.
  
  
  RESULTS
  The mean spherical equivalent refraction (SE) was -7.08 diopters (D) +/- 1.11 (SD) preoperatively. Six months after surgery, 37 eyes (77.1%) achieved an uncorrected visual acuity (UCVA) of 20/20 or better, all eyes had a UCVA of 20/40 or better and 45 (93.7%) eyes had an SE within +/- 1.00D. One month postoperatively, 2 eyes (3.7%) had grade 0.5+ of haze, while at 3 and 6 months after surgery no visited eye had haze at all. All eyes had a best corrected visual acuity (BCVA) of 20/40 or better and there were no lost lines in BCVA by 6 months after surgery. In spatial frequencies of 6 and 12 cycles per degree contrast sensitivity had decreased immediately after PRK and it had increased 1.5 lines by the 6th postoperative month compared to the preoperative data.
  
  
  CONCLUSIONS
  The results show the efficacy of mitomycin-C in preventing corneal haze after treatment of high myopia with PRK. This method- PRK + mitomycin-C - can be considered an alternative treatment for myopic patients whose corneal thicknesses are inadequate for laser in situ keratomileusis (LASIK). However, the results should be confirmed in longer follow-ups.
authors.affiliation: Farabi Eye Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. hhashemi@tums.ac.ir
authors.forename: Hassan
authors.initials: H
authors.lastname: Hashemi
authors.forename: Seied Mohammad Reza
authors.initials: SM
authors.lastname: Taheri
authors.forename: Akbar
authors.initials: A
authors.lastname: Fotouhi
authors.forename: Azita
authors.initials: A
authors.lastname: Kheiltash
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003318:Corneal Opacity / Q000517:prevention & control*; D006801:Humans; D054018:Lasers, Excimer; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009216:Myopia / Q000601:surgery*; D018903:Photorefractive Keratectomy; D011446:Prospective Studies; D014792:Visual Acuity
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin