title: [Allele Frequency Analysis of Four Single Nucleotide Polymorphisms Locating in Promoter and 5'-Untranslated Regions of ABCAI Gene in Young Men - Survivors From Myocardial Infarction].
abstract: Analysis of allele distribution of four single nucleotide polymorphisms (C-17G, C69T, G-191C and 319insG) of promoter and 5'-untranslated regions of the ABCA1 gene was carried out in a sample of 171 men, who had survived myocardial infarction before 45 years, and in controls. Two-fold increase of T69 and C-191 allele frequencies were observed in Russian population in comparison to Dutch one. While comparing allele and genotype distributions of the polymorphisms in the samples under study no statistically significant differences were found, so as no influence of different alleles on lipid spectrum data was observed. Role of polymorphisms under study appears to be insignificant in formation of genetic susceptibility to myocardial infarction in young men.
authors.affiliation: State Medical University; Research Institute for Physicochemical Medicine; ul. Malaya Pirogovskaya, 1a, 119828 Moscow, National Medical Surgery Center, Moscow, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Sheĭdina
authors.forename: S N
authors.initials: SN
authors.lastname: Pchelina
authors.forename: D V
authors.initials: DV
authors.lastname: Demidova
authors.forename: T I
authors.initials: TI
authors.lastname: Rodygina
authors.forename: A E
authors.initials: AE
authors.lastname: Taraskina
authors.forename: O B
authors.initials: OB
authors.lastname: Toperverg
authors.forename: O A
authors.initials: OA
authors.lastname: Berkovich
authors.forename: E V
authors.initials: EV
authors.lastname: Demina
authors.forename: E I
authors.initials: EI
authors.lastname: Shvarts
authors.forename: T V
authors.initials: TV
authors.lastname: Pogoda
authors.forename: E V
authors.initials: EV
authors.lastname: Generozov
authors.forename: V M
authors.initials: VM
authors.lastname: Govorun
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Lopukhin
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Shevchenko
mesh_terms: D020121:5' Untranslated Regions; D005787:Gene Frequency; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D017741:Survivors
chemical_list: D020121:5' Untranslated Regions