C-reactive protein in the differentiation of pyometra from cystic endometrial hyperplasia/mucometra in dogs.
Hematological parameters, plasma C-reactive protein (CRP), and tumor necrosis factor alpha were analyzed in 64 dogs with a presumptive diagnosis of pyometra. Final diagnosis (i.e., pyometra or cystic endometrial hyperplasia [CEH]) was determined by histopathology. As a single test, the percentage of band neutrophils had the highest sensitivity in the prediction of pyometra (sensitivity, 94%). The combination of percentage of bands and CRP had the highest sensitivity (97.7%; specificity, 75%) in predicting the presence of pyometra. The most common clinical signs noted in the study were vaginal discharge, polyuria, polydipsia, lethargy, and gastrointestinal signs. A combination of three or more of these clinical signs was significantly associated with pyometra.
Fransson
Boel A
BA
Departments of Veterinary Clinical Sciences, Washington State University, Pullman, Washington 99164-7060, USA.
Karlstam
Erika
E
Bergstrom
Annika
A
Lagerstedt
Anne-Sofie
AS
Park
Jean S
JS
Evans
Marc A
MA
Ragle
Claude A
CA
D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D004714:Endometrial Hyperplasia / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D005260:Female; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000097:blood; D014591:Uterine Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*
D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein