title: [Effect of injection of testosterone undecanoate and depot medroxyprogesterone acetate on the suppression of spermatogenesis].
abstract: OBJECTIVE
  To observe depot medroxyprogesterone acetate (DMPA) and testosterone undecanoate (TU) injected at 8-week intervals for the suppression of spermatogenesis in healthy Chinese men.
  
  
  METHODS
  After screening, 30 healthy volunteers were enrolled and randomly assigned to 3 dosage-groups (n = 10/group): 1000 mg TU (Group A), 1000 mg TU plus 150 mg DMPA (Group B), 1000 mg TU plus 300 mg DMPA (Group C). All dosages were given as intramuscular injections at 8-week intervals. The study consisted of an 8-week control (baseline) period, a 24-week treatment period and a 24-week recovery period.
  
  
  RESULTS
  Consistent azoospermia or severe oligozoospermia was achieved and maintained in all the volunteers during the treatment period, except 2 in the mere TU group who experienced a "rebound" in sperm concentrations. An 8-week regimen of TU plus DMPA at both tested combination dosages effectively suppressed spermatogenesis to azoospermia. All volunteers tolerated the injections; no serious adverse effects were reported.
  
  
  CONCLUSIONS
  The lower combined dosage is recommended for further testing in an expanded clinical trial or contraceptive efficacy study.
authors.affiliation: Department of Urology, the Third Hospital of Peking University, Beijing 100083, China. tangwenhao9696@hotmail.com
authors.forename: Wenhao
authors.initials: W
authors.lastname: Tang
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Gu
authors.forename: Jiansun
authors.initials: J
authors.lastname: Tong
authors.forename: Dingzhi
authors.initials: D
authors.lastname: Ma
authors.forename: Xinghai
authors.initials: X
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Yuan
authors.forename: Zhenwen
authors.initials: Z
authors.lastname: Chen
authors.forename: William J
authors.initials: WJ
authors.lastname: Bremner
mesh_terms: D000328:Adult; D000728:Androgens / Q000494:pharmacology*; D002681:China; D007987:Gonadotropin-Releasing Hormone / Q000096:biosynthesis; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D011446:Prospective Studies; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000728:Androgens; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D017258:Medroxyprogesterone Acetate; C010792:testosterone undecanoate