title: Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD.
abstract: Interactions between environmental and genetic factors may contribute to neurodegenerative disease. In this issue of Neuron, Calon et al. report that a diet low in an essential omega-3 polyunsaturated fatty acid (docosahexaenoic acid) depletes postsynaptic proteins and exacerbates behavioral alterations in a transgenic mouse model of Alzheimer's disease.
authors.affiliation: Gladstone Institute of Neurological Disease, University of California, San Francisco, PO Box 419100, 94103, USA.
authors.forename: Lennart
authors.initials: L
authors.lastname: Mucke
authors.forename: Robert E
authors.initials: RE
authors.lastname: Pitas
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism / Q000627:therapeutic use; D018384:Oxidative Stress / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D004281:Docosahexaenoic Acids