title: Synthesis and evaluation of novel oxazoline MMP inhibitors.
abstract: MMP inhibitors with novel oxazoline zinc binding groups have been synthesized and evaluated. Selectivity for the inhibition of MMP-9 over MMP-1, MMP-2, and MMP-12 has been achieved in several cases.
authors.affiliation: Center for Protease Research, Department of Chemistry, Biochemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105, USA. gregory.cook@ndsu.nodak.edu
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Cook
authors.forename: Ethirajan
authors.initials: E
authors.lastname: Manivannan
authors.forename: Thane
authors.initials: T
authors.lastname: Underdahl
authors.forename: Viera
authors.initials: V
authors.lastname: Lukacova
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhang
authors.forename: Stefan
authors.initials: S
authors.lastname: Balaz
mesh_terms: D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D010080:Oxazoles; D011480:Protease Inhibitors; D020782:Matrix Metalloproteinases