title: FISH analysis helps identify low-level mosaicism in Ullrich-Turner syndrome patients.
abstract: OBJECTIVE
  To search for X or Y chromosome mosaicism in 45,X individuals using fluorescent in situ hybridization (FISH).
  
  
  METHODS
  From our series of 53 Ullrich-Turner syndrome patients, we used interphase FISH to evaluate the 19 who had an apparently nonmosaic 45,X karyotype with G-banding.
  
  
  RESULTS
  Of those 19 patients, mosaicism was detected in seven (37%), five patients had an XX line, one had a monocentric isochromosome X, and one had a dicentric isochromosome X. No Y chromosome mosaic was identified.
  
  
  CONCLUSIONS
  FISH analysis is a sensitive and cost-effective adjunct to karyotype analysis to identify sex chromosome mosaicism in UTS.
authors.affiliation: Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Wiktor
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Van Dyke
mesh_terms: D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping / Q000379:methods; D009030:Mosaicism; D011237:Predictive Value of Tests; D012729:Sex Chromosome Aberrations; D014424:Turner Syndrome / Q000235:genetics*
chemical_list: D005456:Fluorescent Dyes