title: First diastereoselective intramolecular Baylis-Hillman reaction: an easy access to chiral alpha-methylene-beta-hydroxylactones.
abstract: The first diastereoselective intramolecular Baylis-Hillman reaction of chiral substrates is reported wherein both aldehyde and activated olefin coexist as substituents to afford alpha-methylene-beta-hydroxylactones in good yields exclusively as single isomers under the standard base-catalyzed reaction conditions in CH(2)Cl(2). Formation of alkoxylactones by an in situ derivatization of adducts was also observed.
authors.affiliation: D-206/B, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India. prkgenius@iict.res.in
authors.forename: Palakodety Radha
authors.initials: PR
authors.lastname: Krishna
authors.forename: V
authors.initials: V
authors.lastname: Kannan
authors.forename: G V M
authors.initials: GV
authors.lastname: Sharma