title: Lowe syndrome: proton mr spectroscopy, and diffusion mr imaging.
abstract: A 3-year-old boy with Lowe syndrome had bilateral periatrial hyperintense lesions intermixed with small cyst-like changes in the periatial regions of the deep white matter at MR imaging. Proton MR spectroscopy revealed prominent myoinositol peaks suggesting the presence of gliosis. b = 1000 s/mm2 images of diffusion MR imaging were negative for the periatrial lesions. ADC maps, however, revealed high ADC values (1.76, and 1.66 x 10(-3) mm2/s), compared to the normal brain parenchyma (0.81 x 10(-3) mm2/s). These diffusion MR imaging findings likely represented gliosis.
authors.affiliation: Department of Radiology, Ege University Hospital, Bornova, 35100 Izmir, Turkey. rnsener@med.ege.edu.tr
authors.forename: R N
authors.initials: RN
authors.lastname: Sener
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002675:Child, Preschool; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003560:Cysts / Q000175:diagnosis / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005911:Gliosis / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009800:Oculocerebrorenal Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology*; D012016:Reference Values
chemical_list: D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline