title: Opening cerebrospinal fluid pressure guides the management of cerebrospinal fluid leakage after acoustic neuroma surgery.
abstract: OBJECTIVE
  To assess the value of cerebrospinal fluid pressure as a decisional factor for immediate surgical revision in cerebrospinal fluid leakage after acoustic neuroma removal.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Between 1998 and 2001, 220 patients were operated on for acoustic neuroma by different transpetrosal approaches. Among 24 patients (12%) presenting postoperative cerebrospinal fluid leakage, those with meningitis or with hydrocephalus were excluded. Fifteen patients were included in this study.
  
  
  METHODS
  Each patient had initial conservative treatment with serial depletive lumbar punctures and cerebrospinal fluid pressure measurements associated with oral acetazolamide. Surgical revision was decided on in case of persistent cerebrospinal fluid leakage.
  
  
  RESULTS
  In eight patients with high cerebrospinal fluid pressure (18+/-1.4 cm H2O; range, 14-28 cm H2O), cerebrospinal fluid leak disappeared in 3 days after conservative treatment. Seven other patients required surgical revision for persistent cerebrospinal fluid leakage. Revision surgery was efficient in six patients with low cerebrospinal fluid pressure (8+/-1.3 cm H2O, range, 3-12 cm H2O). In the remaining patient with high cerebrospinal fluid pressure (18 cm H2O), cerebrospinal fluid leakage continued despite surgical revision, requiring lumboperitoneal shunting.
  
  
  CONCLUSIONS
  The cerebrospinal fluid pressure value may be used as a decisional indicator for cerebrospinal fluid leakage treatment after acoustic neuroma surgery. Low cerebrospinal fluid pressure leakage would imply a revision surgery procedure without delay, whereas high cerebrospinal fluid pressure leakage would imply conservative treatment.
authors.affiliation: Neurosurgery Department, Hôpital Beaujon, AP-HP, Clichy, France. michel.kalamarides@bjn.ap-hop-paris.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Kalamarides
authors.forename: Alexis Bozorg
authors.initials: AB
authors.lastname: Grayeli
authors.forename: Didier
authors.initials: D
authors.lastname: Bouccara
authors.forename: Aimée
authors.initials: A
authors.lastname: Redondo
authors.forename: Alain
authors.initials: A
authors.lastname: Rey
authors.forename: Olivier
authors.initials: O
authors.lastname: Sterkers
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology / Q000628:therapy*; D035301:Cranial Fossa, Middle; D003392:Cranial Sinuses; D004232:Diuretics / Q000627:therapeutic use; D007758:Ear, Inner; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009464:Neuroma, Acoustic / Q000601:surgery*; D013506:Otologic Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy*; D012086:Reoperation; D012189:Retrospective Studies; D013129:Spinal Puncture
chemical_list: D004232:Diuretics; D000086:Acetazolamide