title: Effect of age on the pupillomotor field.
abstract: To differentiate physiologic variation from visual field loss with pupillomotor perimetry, the effect of age on the normal pupillomotor field must be known. Given the absence of reported data, the authors aimed to analyze the effect of age on the pupillomotor field as measured with light stimuli of different properties. Subjects consisted of 23 healthy volunteers aged 20 to 28 years ("younger subjects") and 20 healthy volunteers aged 50 to 67 years ("older subjects"). Within a field of 20 degrees, a sequence of 25 focal light stimuli was performed repeatedly on a monitor. The pupil light reflex (PLR) was recorded to stimuli of different diameter and luminance under mesopic conditions. The mean amplitude of the PLR was calculated for each stimulus location and condition. Increasing stimulus luminance or size caused a larger PLR amplitude and a steeper decline of the PLR amplitude from the center to the periphery of the pupillomotor field. The older subjects had reduced mean PLR amplitude with a less pronounced decrease of PLR amplitude toward the field periphery. For the peripheral locations, the largest PLR amplitude was found in the temporal superior quadrants. There was considerable intra-individual test-retest variation in PLR amplitudes in younger and older subjects. The PLR is markedly reduced in older compared with younger subjects. Older subjects have a relatively less pronounced central peak of sensitivity. There are intra-individual test-retest variations in PLR amplitude and asymmetries in sensitivity within the normal pupillomotor field at any age. These findings must be considered in interpreting the results of pupillomotor perimetry.
authors.affiliation: University Eye Hospital, Department of Neuro-ophthalmology and Pathophysiology of Vision, Schleichstrasse 12-16, D-72076 Tuebingen, Germany.
authors.forename: Ruediger
authors.initials: R
authors.lastname: Schmid
authors.forename: Per
authors.initials: P
authors.lastname: Ceurremans
authors.forename: Holger
authors.initials: H
authors.lastname: Luedtke
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Wilhelm
authors.forename: Helmut M
authors.initials: HM
authors.lastname: Wilhelm
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011680:Pupil / Q000502:physiology*; D012025:Reflex, Pupillary; D014794:Visual Fields / Q000502:physiology*