[Clinical significance of expression of VEGF and bFGF in thyroid carcinoma].
OBJECTIVE
To study the clinical significance of expression of VEGF and bFGF in thyroid carcinoma.


METHODS
Immunohistochemical SP technic was used to investigate the expression of VEGF and bFGF in 90 cases of papillary carcinoma, 14 cases of undifferentiated carcinoma, 10 cases of normal thyroid tissue.


RESULTS
The positive rate of VEGF and bFGF in thyroid carcinoma was 63.5% and 59.6% respectively, Which was significantly higher than that in normal thyroid tissue (P < 0.01); The positive rate of VEGF and bFGF in undifferentiated carcinoma was 92.9% and 85.7% respectively, which was significantly higher than that in papillary carcinoma (P < 0.05); The positive rate of expression of VEGF and bFGF was correlated with lymph gland metastasis (P < 0.05); A positive correlation between these two expresses existed in thyroid carcinoma (gamma = 0.596, P < 0.05).


CONCLUSIONS
VEGF and bFGF can be regarded as a parameter to evaluate the biological behavior and prognosis of thyroid carcinoma.
Tian
Xiao-feng
XF
Department of General Surgery, The Chinese-Japan Union Hospital of Jilin University, Changchun 130021, China.
Zhang
Xue-wen
XW
Chen
Rui-xin
RX
Wang
Jian-wei
JW
Zhang
Dan
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000378:metabolism / Q000556:secondary; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000556:secondary; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism*
D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2