title: Detection of metabolic abnormality in asynergic regions of ischemic human myocardium using 31P and 1H magnetic resonance spectroscopy.
abstract: To assess quantitatively phosphocreatine (PCr), adenosine triphosphate (ATP) and total creatine (CR) in asynergic regions of ischemic human myocardium using phosphorus (31P) and proton magnetic resonance spectroscopy (1H MRS). Patients were divided into two groups: 31P MRS and 1H MRS. In each group, patients were subdivided into three groups using echocardiography: a normokinetic [WN(P) (n = 6) in 31P MRS, WN(H) (n = 10) in 1H MRS], a hypokinetic [WH(P) (n = 13), WH(H) (n = 7)], and a- or dyskinetic wall motion groups [WA(P) (n = 14), WA(H) (n =6)]. They were compared with normal subjects of each group [CNP (n = 10), CN(H) (n = 10)]. 31P MRS spectra were obtained from the anterior and apical regions of the left ventricle by slice-selected 1D CSI. 1H MRS spectra were obtained from the 2 x 2 x 2-cm voxel set in the left ventricular wall by the PRESS method. In the 31P MRS group, myocardial PCr was significantly lower in the WH(P) and WA(P) groups than in the CN(P) group, but myocardial PCr in the WN(P) group did not differ from that in CN(P). A difference in ATP could not be detected among the four groups. In the 1H MRS group, myocardial CR was significantly lower in the WH(H) and WA(H) groups than in the CN(H) group. Myocardial CR in the WNH group did not differ from that in the CN(H). The noninvasive 31P and 1H MRS approach is useful in the assessment of metabolite reduction associated with wall motion abnormality.
authors.affiliation: Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakae
authors.forename: Kenichi
authors.initials: K
authors.lastname: Mitsunami
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yabe
authors.forename: Toshiro
authors.initials: T
authors.lastname: Inubushi
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Morikawa
authors.forename: Shinro
authors.initials: S
authors.lastname: Matsuo
authors.forename: Terue
authors.initials: T
authors.lastname: Koh
authors.forename: Minoru
authors.initials: M
authors.lastname: Horie
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D003401:Creatine / Q000378:metabolism*; D020820:Dyskinesias / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D010758:Phosphorus; D011522:Protons
chemical_list: D011522:Protons; D010758:Phosphorus; D000255:Adenosine Triphosphate; D003401:Creatine