title: Effect of incadronate on corticosteroid-induced osteopenia in rats.
abstract: The effect of incadronate, a third-generation bisphosphonate, was evaluated in rats with corticosteroid-induced osteopenia. Male Wistar rats were treated with methylprednisolone acetate (1 mg/kg, s.c.) once daily, 3 days a week for 12 weeks. Other groups received simultaneous treatment with methylprednisolone acetate and incadronate (0.03, 0.3 or 3 mg/kg, p.o.); incadronate was given once daily, 6 days a week for 12 weeks. Bone mineral densities (BMDs) of the second lumbar (L2) vertebra as well as the ultimate compressive strength of the fifth lumbar (L5) vertebra decreased. Incadronate dose-dependently inhibited the loss of L2 BMDs and the decrease in strength of the L5 vertebrae. These results suggest that incadronate may be effective in treating osteopenia accompanying corticosteroid therapy.
authors.affiliation: Inflammation Research, Pharmacology Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Tsukuba City, Japan. takahasi@yamanouchi.co.jp
authors.forename: Koichiro
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shinji
authors.initials: S
authors.lastname: Fukushima
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Nozaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kokubo
authors.forename: Kyoko
authors.initials: K
authors.lastname: Teramura
authors.forename: Keiji
authors.initials: K
authors.lastname: Miyata
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001851:Bone Diseases, Metabolic / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D019245:Compressive Strength / Q000187:drug effects; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D000077555:Methylprednisolone Acetate; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004164:Diphosphonates; C071542:cimadronate; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone