title: Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity.
abstract: A phytochemical analysis of Aster sedifolius has led to the isolation of three novel triterpenoid saponins, based on an oleane-type skeleton and named astersedifolioside A (1), B (2) and C (3). On the basis of chemical, and 2D NMR and mass spectrometry data, the structures of the new compounds were elucidated as 3-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside] (1), 3-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-beta-D-xylopyranosyl (1-->4)-O-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside] (2) and 3-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-beta-D-xylopyranosyl (1-->4)-O-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside] (3). The isolated compounds showed antiproliferative effect in KiMol, a transformed thyroid cell line.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Corea
authors.forename: Maria
authors.initials: M
authors.lastname: Iorizzi
authors.forename: Virginia
authors.initials: V
authors.lastname: Lanzotti
authors.forename: Maria
authors.initials: M
authors.lastname: Cammareri
authors.forename: Clara
authors.initials: C
authors.lastname: Conicella
authors.forename: Chiara
authors.initials: C
authors.lastname: Laezza
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bifulco
mesh_terms: D000818:Animals; D019659:Asteraceae; D002460:Cell Line; D006131:Growth Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D006131:Growth Inhibitors; D010936:Plant Extracts; D012503:Saponins; D009828:Oleanolic Acid