Arylsulfonyl acridinyl derivatives acting on Plasmodium falciparum.
Several arylacridinyl sulfones have been synthesized and their antimalarial action was tested on Plasmodium falciparum. PABA (para-aminobenzoic acid) has no antagonistic effect with these compounds as opposed to the observed effect with dapsone and sulfonamides previously studied. A possible relationship between the ability of cleavage of the S-9C acridinic bond and activity is suggested.
Santelli-Rouvier
Christiane
C
GERCTOP-UMR CNRS 6009, faculté de pharmacie, université de la Méditerranée, 27, boulevard Jean Moulin, 13385 Marseille cedex 5, France. christiane.santelli@pharmacie.univ-mrs.fr
Pradines
Bruno
B
Berthelot
Michel
M
Parzy
Daniel
D
Barbe
Jacques
J
D010129:4-Aminobenzoic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000166:Acridines / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology*; D001190:Arylsulfonates / Q000138:chemical synthesis / Q000494:pharmacology*; D003622:Dapsone / Q000494:pharmacology; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests / Q000706:statistics & numerical data; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology
D000166:Acridines; D000962:Antimalarials; D001190:Arylsulfonates; D013449:Sulfonamides; D003622:Dapsone; D010129:4-Aminobenzoic Acid