[Influence of electro-acupuncture of Neiguan on plasmic concentrations of NO and TNFalpha in endotoxin shock rats].
OBJECTIVE
To observe the effect of electro-acupuncture of Neiguan (PC 6) on mean systemic arterial blood pressure and plasmic concentrations of NO and TNFalpha in endotoxin shock rats.


METHODS
The model of endotoxin shock was induced by lipopolysaccharide (1.5 mg/kg i.v.) and D-galactosamine (100 mg/kg i.p.). Aminoguanidine (100 mg/kg i.p.) and electro-acupuncture of bilateral Neiguan (PC 6) were administered. A catheter was inserted into the right subclavian artery to record the change of blood pressure and the blood was abstracted out and centrifuged to determine the NO and TNFalpha concentrations.


RESULTS
Electro-acupuncture of Neiguan (PC 6) retrieved the blood pressure and reduced the plasmic NO and TNFalpha concentrations.


CONCLUSIONS
Electro-acupuncture of Neiguan (PC 6) expresses an anti-endotoxin shock effect by repressing the plasmic NO and TNFalpha concentrations smoothly and retrieving the blood pressure stably.
Li
Hui
H
Departmant of Anatomy, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province 510405, China. li_hui@163.net
Li
Chun
C
Du
Shao-Hui
SH
Li
Yi-Wei
YW
Chen
Dong-Feng
DF
D015669:Acupuncture Points; D000818:Animals; D001794:Blood Pressure; D015671:Electroacupuncture; D005260:Female; D006146:Guanidines / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012772:Shock, Septic / Q000097:blood / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D006146:Guanidines; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; C004479:pimagedine