title: [A case of successful desensitization therapy for isoniazid-induced pneumonitis].
abstract: A 65-year-old man was admitted to hospital for treatment of pulmonary tuberculosis. He was treated with isoniazid (INH), rifampicin (RFP), ethambutol (EB), and pyrazinamide (PZA). On the 14th day, he developed a fever and interstitial pneumonia, which improved promptly after discontinuation of the antituberculous drugs. Drug lymphocyte stimulation tests against INH, RFP and PZA were negative. However, the provocation test on INH (only) was positive, leading to a diagnosis of pneumonitis caused by INH. We then tried desensitization of INH over a period of two weeks, which was successful and occurred without any clinical event. In the past, five cases of INH-induced pneumonitis were reported, but desensitization of INH did not occur in any. We conclude that physicians should be aware not only of paradoxical reactions but also of drug-induced pneumonitis when a new pulmonary infiltrate develops in the course of tuberculosis treatment. Furthermore, drug desensitization may be possible in some cases of drug-induced pneumonitis.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization, Kanazawa Wakamatsu Hospital, Se 103-1 Wakamatsu-machi, Kanazawa, Ishikawa 920-1183, Japan.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Nishizawa
authors.forename: Masahide
authors.initials: M
authors.lastname: Yasui
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yamamori
authors.forename: Atsurou
authors.initials: A
authors.lastname: Tagami
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujimura
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000368:Aged; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage; D000995:Antitubercular Agents / Q000009:adverse effects*; D003888:Desensitization, Immunologic; D004977:Ethambutol / Q000008:administration & dosage; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D011014:Pneumonia / Q000139:chemically induced* / Q000628:therapy*; D012293:Rifampin / Q000008:administration & dosage; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
chemical_list: D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin