IgA-dominant glomerulonephritis associated with hepatitis A.
Unlike hepatitis B and C, renal involvement has been extremely uncommon in patients with hepatitis Avirus (HAV) infection. Nephrotic syndrome has been documented as a rare complication in association with HAV infection. In this report, we describe a patient with serologically documented HAV infection, who presented with nephrotic syndrome. The renal biopsy showed an immunoglobulin A- (IgA) dominant glomerulonephritis (GN) with subendothelial immune deposits. This is the second biopsy-proven case report of a patient with acute HAV associated with IgA-dominant immune complex glomerulonephritis and nephrotic syndrome. This is perhaps the first case in which a patient experienced both IgA-dominant glomerulonephritis and cutaneous cryoglobulinemic vasculitis.
Cheema
S R
SR
Division of Nephrology, St. Luke's-Roosevelt Hospital Center, College of P&S of Columbia University, New York, NY, USA. shafiqcheema@yahoo.com
Arif
F
F
Charney
D
D
Meisels
I S
IS
Cheema
S S
SS
D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology; D006506:Hepatitis A / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged