Biology and management of gastric carcinoid tumours: a review.
In recent times gastric carcinoid tumours have become the subject of substantial clinical interest as knowledge of their biological background and clinical importance has increased Gastric carcinoid tumours have long been considered rare lesions, amounting to less than 2% of all carcinoid tumours and less than 1% of all stomach neoplasms. New large databases suggest that the prevalence of gastric carcinoid is rising, with a true value now closer to 5% of all carcinoids. A tripartite classification system for gastric carcinoid tumours is now in common use: tumours associated with chronic atrophic gastritis; tumours associated with Zollinger-Ellison syndrome; and sporadic lesions. Gastric carcinoids associated with hypergastrinaemia are relatively benign, while sporadic lesions require aggressive surgical management. Gastric carcinoids, however, can be managed initially by endoscopic excision of accessible tumours, followed by regular endoscopic surveillance.
Modlin
Irvin M
IM
Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Kidd
Mark
M
Lye
Kevin D
KD
D002276:Carcinoid Tumor / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004759:Enterochromaffin Cells / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005757:Gastritis, Atrophic / Q000150:complications / Q000473:pathology; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D008297:Male; D008967:Molecular Biology; D018570:Risk Assessment; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome; D015043:Zollinger-Ellison Syndrome / Q000150:complications / Q000473:pathology