title: Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate.
abstract: An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H(3)]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.
authors.affiliation: National Centre for Cell Science, Pune University Campus, Pune 411007, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Shukla
authors.forename: Vivek
authors.initials: V
authors.lastname: Barve
authors.forename: Subhash
authors.initials: S
authors.lastname: Padhye
authors.forename: Ramesh
authors.initials: R
authors.lastname: Bhonde
mesh_terms: D000818:Animals; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008280:Magnetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000494:pharmacology; D011753:Pyrones / Q000494:pharmacology; D011794:Quercetin / Q000138:chemical synthesis* / Q000494:pharmacology; D014638:Vanadates / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D008934:Mitogens; D011753:Pyrones; C075743:oxovanadium IV; C074212:bis(maltolato)oxovanadium(IV); D014638:Vanadates; D011794:Quercetin