Effects of trifluoromethyl ketones on the motility of Proteus vulgaris.
In the present study, we showed the inhibition of motility by trifluoromethyl ketone (TF) derivatives (1-8) in Proteus vulgaris (P. vulgaris) cultures. Among them, 1-(2-benzoxazoyl)-3,3,3-trifluoro-2-propanone (1) showed a much stronger inhibitory effect on the motility of P. vulgaris than other TF compounds at 10% MIC. Our results suggest the possibility of an inhibitory action of TF compounds on the proton motive forces by affecting the action of biological motor and proton efflux in the membranes, resulting in a reduction of the ratio of running and the increased number of tumbling and non-motile cells.
Wolfart
Krisztina
K
Department of Medical Microbiology, Faculty of General Medicine, University of Szeged, Szeged, H-6720, Hungary.
Molnar
Annamaria
A
Kawase
Masami
M
Motohashi
Noboru
N
Molnar
Joseph
J
D007659:Ketones / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009068:Movement / Q000187:drug effects; D011514:Proteus vulgaris / Q000187:drug effects*
D007659:Ketones