Acute renal failure during eclampsia: incidence risks factors and outcome in intensive care unit.
OBJECTIVE
To assess the incidence, risk factors and the outcome of acute renal failure (ARF) associated with eclampsia in intensive care unit (ICU).


METHODS
Prospective and analytic study.


METHODS
A surgical ICU in a university hospital.


METHODS
178 consecutive women with eclampsia admitted to an intensive care unit during seven years. ARF was defined by a serum creatinine concentration >140 micromol/L.


RESULTS
The incidence of ARF was 25.8%. In univariate analysis the severity of patient illness, the complications associated with eclampsia (disseminated intravascular coagulation, Hellp syndrome, neurologic complications, abruptio placenta, aspiration pneumonia, delivery hemorrhage) were significantly associated with ARF. In a logistic regression model, risk factors for ARF included organ system failure (OSF) odds ratio (OR)=1.81 confidence interval (CI) [1.08-3.05], bilirubin >12 micromol/L OR=4.42 CI [1.54-12.68], uric acid >5.9 g/dL OR=16.5 CI [3.09-87.94], abruptio placenta OR=0.2 7 CI [0.08-0.99], and oliguria OR=0.10 CI [0.03-0.44]. In contrast, severity of blood pressure or proteinuria on dipstick were not associated with ARF. However, in this series, 15 women required dialysis in the short term and one required long-term dialysis. ARF associated with eclampsia was significantly associated with mortality (32.6% versus 9.1% p=0.0001).


CONCLUSIONS
ARF with eclampsia is a frequent situation that required intensive management when risks factors were present. The need for dialysis was a rare condition.
Mjahed
Khalid
K
Service d'anesthésie-réanimation centrale, CHU Ibn Rochd, Casablanca, Morocco. kmjahed@yahoo.fr
Alaoui
Sd Youssef
SY
Barrou
Lhoucine
L
D058186:Acute Kidney Injury / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D000328:Adult; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D004461:Eclampsia / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D016015:Logistic Models; D011247:Pregnancy; D011446:Prospective Studies; D006435:Renal Dialysis; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome
D004232:Diuretics; D005665:Furosemide; D003404:Creatinine; D004298:Dopamine