Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice.
Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.
Durkin
Michelle M
MM
MiraVista Diagnostics/MiraBella Technologies, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241, USA.
Connolly
Patricia A
PA
Karimi
Kian
K
Wheat
Emerson
E
Schnizlein-Bick
Carol
C
Allen
Stephen D
SD
Alves
Katia
K
Tewari
Ram P
RP
Keath
Elizabeth
E
D000818:Animals; D004195:Disease Models, Animal; D006658:Histoplasma / Q000145:classification* / Q000302:isolation & purification; D006660:Histoplasmosis / Q000473:pathology*; D007843:Latin America; D051379:Mice; D009656:North America