Placental soluble fms-like tyrosine-kinase-1 (sFlt-1) in pregnant women with preeclampsia.
The pathophysiology of preeclampsia remains largely unknown. A number of circulating placenta-produced factors have been implicated in causing the endothelial dysfunction and the clinical phenotype characteristic of preeclampsia.


OBJECTIVE
Determination of serum levels of placental soluble fms-like tyrosine-kinase-1 (sFlt-1) in pregnant women with preeclampsia. Eleven pregnant women with preeclampsia and 11 healthy women (controls) were included in the study. Determination of sFlt-1 was done with ELISA. The mean serum sFlt-1 levels of pregnant women with preeclampsia were twice as high as that of women with normal pregnancy. The highest level of sFlt-1 was found in women with severe preeclampsia. In women with mild form of preeclampsia the sFlt-1 level was close to that of the controls. sFlt-1 appears to be involved in the pathogenesis of preeclampsia and its serum levels can be used as a diagnostic marker of preeclampsia.
Dimitrakova
Elena D
ED
Clinic of Obstetrics and Gynecology, Medical University - Plovdiv, Bulgaria.
Dimitrakov
Jordan D
JD
Karumanchi
S A
SA
Karumanchi
S G
SG
Pehlivanov
Blagovest K
BK
Milchev
Nikola P
NP
Dimitrakov
Dimitar I
DI
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D016326:Extracellular Matrix Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy
D016326:Extracellular Matrix Proteins