title: Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy.
abstract: The three goals of this article are (1) to delineate the limitations in determining the actual incidence of antiepileptic drug (AED) psychiatric and behavioral side effects; (2) to summarize existing data on the direct effects of AEDs on psychiatric and behavioral comorbidities and examine the relationship between these direct effects and specific AED mechanisms of action; and (3) to recognize the indirect effects of AEDs on psychiatric and behavioral medications that can result in aggravation of these comorbidities through drug-drug interactions. All of these data are then combined and formatted into a practical algorithm useful in many clinical situations.
authors.affiliation: Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. glauser@cchmc.org
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Glauser
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D001526:Behavioral Symptoms / Q000188:drug therapy / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000927:Anticonvulsants