title: Treatment of basal cell carcinoma with the pulsed carbon dioxide laser: a retrospective analysis.
abstract: OBJECTIVE
  Treatment options for basal cell carcinoma include surgical excision, cryotherapy, radiation, photodynamic therapy, Moh's micrographic surgery, and topical treatment with 5-fluorouracil and immunomodulators such as imiquimod. Resurfacing and ablation with a CO(2) laser (UltraPulse, Coherent Inc.) may present an attractive and effective treatment option in the management of these cutaneous cancers. We demonstrate the efficacy and safety of the UltraPulse CO(2) in the treatment of basal cell carcinomas of the skin.
  
  
  METHODS
  We performed a retrospective chart review of 23 patients treated with the UltraPulse CO(2) laser. A total of 61 biopsy-proven superficial and nodular basal cell carcinomas without prior treatment were included in the study. The patients were followed postoperatively for a period of 15 to 85 months (mean 41.7 months) and assessed for clinical recurrence.
  
  
  RESULTS
  Of the 61 tumors treated, clinical recurrence was observed in two cases (3.2%). Adverse effects included significant hypertrophic scarring in one patient and hypopigmentation in one patient.
  
  
  CONCLUSIONS
  Destruction of superficial and nodular basal cell carcinomas may be accomplished successfully and safely with the UltraPulse CO(2) laser with a cure rate of 97%.
authors.affiliation: Dermatology Associates of San Diego County, Skin and Laser Surgery Center of La Jolla, La Jolla, California 92037, USA.
authors.forename: Shilesh
authors.initials: S
authors.lastname: Iyer
authors.forename: Leyda
authors.initials: L
authors.lastname: Bowes
authors.forename: Greg
authors.initials: G
authors.lastname: Kricorian
authors.forename: Andre
authors.initials: A
authors.lastname: Friedli
authors.forename: Richard E
authors.initials: RE
authors.lastname: Fitzpatrick
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*