title: [Study on Realgar inducing apoptosis in T lymphocytic cell line CEM].
abstract: OBJECTIVE
  To study the Realgar induced T lymphocytic leukemia cell line CEM apoptosis in vitro.
  
  
  METHODS
  CEM cells were incubated with Realgar. Cell proliferation inhibition was determined by MTT. Cell cycle, apoptosis, Apo2.7 and Fas were measured by cytometer.
  
  
  RESULTS
  Realgar inhibited the proliferation of CEM cell line. The cells treated with Realgar showed a Sub-G(0)/G(1) apoptotic peak in DNA distribution histogram, increment of Apo2.7 protein expression, and arrested cells in G(2)/M phase, but ineffectiveness on Fas expression.
  
  
  CONCLUSIONS
  The Realgar can induce CEM cell apoptosis in vitro.
authors.affiliation: TCM Hematology Institute of People's Liberation Army, Dalian, Liaoning Province 116021, China. zcshsmmu@sina.com
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Huang
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.forename: Ai-Xia
authors.initials: AX
authors.lastname: Guo
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001152:Arsenicals / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015458:Leukemia, T-Cell / Q000378:metabolism* / Q000473:pathology; D013440:Sulfides / Q000494:pharmacology*; D019014:fas Receptor / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D001152:Arsenicals; C491901:FAS protein, human; D013440:Sulfides; D019014:fas Receptor; C058317:arsenic disulfide