title: Role of myeloperoxidase index in differentiation of megaloblastic and aplastic anemia.
abstract: BACKGROUND
  Elevated neutrophil myeloperoxidase may have a role in the diagnosis of megaloblastic erythropoiesis.
  
  
  OBJECTIVE
  To study the differentiating role of myeloperoxidase index in megaloblastic and aplastic anemia.
  
  
  METHODS
  The myeloperoxidase index (MPXI) was studied in 96 patients with megaloblastic and aplastic anemia diagnosed on bone marrow aspiration and biopsy examinations.
  
  
  METHODS
  MPXI was measured with Technicon H1 (Bayer) automated analyzer. Nonparametric Mann-Whitney statistical test was used to compare the MPXI values between groups.
  
  
  RESULTS
  The mean MPXI in megaloblastics and aplastic anemia was 18.3 and 1.8 (p< 0.001) respectively. MPXI> 20 denoted megaloblastic and MPXI <-11.6 denoted aplastic anemia.
  
  
  CONCLUSIONS
  MPXI measurement may assist differentiation of megaloblastic from aplastic anemia, while MPXI> 20 rules out aplastic and MPXI <-11.6 rules out megaloblastic anemia.
authors.affiliation: Hematology and Oncology Department, Imam Hospital, Tabriz, Iran. jziaei@hotmail.com
authors.forename: Jamal Eivazi
authors.initials: JE
authors.lastname: Ziaei
authors.forename: Saeed
authors.initials: S
authors.lastname: Dastgiri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000175:diagnosis*; D000749:Anemia, Megaloblastic / Q000175:diagnosis*; D002648:Child; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D009195:Peroxidase / Q000032:analysis*
chemical_list: D009195:Peroxidase