title: Correlation of peri-implant health and myeloperoxidase levels: a cross-sectional clinical study.
abstract: OBJECTIVE
  At present, there are no diagnostic tools that permit early detection of peri-implantitis. The purpose of this cross-sectional study was to evaluate the correlation of myeloperoxidase (MPO) levels with traditional periodontal clinical parameters around dental implants including peri-implant pocket probing depth (PPD), gingival index (GI) and bleeding on probing (BOP), since MPO has been associated with destruction of periodontal tissues.
  
  
  METHODS
  Twenty-four healthy adult volunteers (9 men and 15 women) with 64 Ankylos Biofunctional implants (DentsplyFriadent, Mannheim, Germany) were recruited from Tallinn Dental Clinic. Biochemical and clinical parameters evaluated were the following ones: the level of MPO in the peri-implant sulcus fluid (PISF) (an analog for gingival crevicular fluid in natural teeth), PPD (mm), GI (0,1,2 or 3), and BOP (0 or 1).
  
  
  CONCLUSIONS
  In comparison to the clinically healthy implants, total amounts of MPO were significantly higher in PISF collected around implants with inflammatory lesions. In addition, the levels of MPO were correlated with the clinical parameters. The results confirm the similarity of the inflammatory response of tissues surrounding implants and natural teeth, and suggest that MPO could be promising marker of inflammation around dental implants.
authors.affiliation: Clinic of Dentistry, Faculty of Medicine, Tartu University, Tartu, Estonia. stalis@hot.ee
authors.forename: Stanislav
authors.initials: S
authors.lastname: Liskmann
authors.forename: Mihkel
authors.initials: M
authors.lastname: Zilmer
authors.forename: Tiiu
authors.initials: T
authors.lastname: Vihalemm
authors.forename: Olev
authors.initials: O
authors.lastname: Salum
authors.forename: Krista
authors.initials: K
authors.lastname: Fischer
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D015921:Dental Implants; D005260:Female; D005883:Gingival Crevicular Fluid / Q000201:enzymology; D005884:Gingival Hemorrhage / Q000145:classification / Q000201:enzymology; D005891:Gingivitis / Q000145:classification / Q000201:enzymology; D006801:Humans; D008297:Male; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000201:enzymology; D010518:Periodontitis / Q000175:diagnosis / Q000201:enzymology*; D010519:Periodontium / Q000201:enzymology*; D009195:Peroxidase / Q000032:analysis*
chemical_list: D015415:Biomarkers; D015921:Dental Implants; D009195:Peroxidase