title: [Treatment of paraneoplastic pemphigus with Castleman's disease].
abstract: OBJECTIVE
  To discuss the clinical findings and treatment of paraneoplastic pemphigus (PNP) with Castleman's disease.
  
  
  METHODS
  To investigate the clinical, histopathologic and CT findings of 8 cases paraneoplastic pemphigus with Castleman's disease.
  
  
  RESULTS
  All of 8 patients were diagnosed PNP first and were found Castleman's tumor incidently during routine examination. All 8 cases showed severe erosion or ulcer of the oral mucosa with various skin lesions. Histopathologically, there were intraepidermal acantholytic vesicle, basal cell liquefaction, necrotic keratinocytes in the epidermis and lymphocyte infiltration in the upper dermis. CT scan appeared solitary mass in these patients. Some of them were attacked by bronchiolitis obliterans. All 8 patients were failed by use of predisone. Obvious relief of PNP and pulmonary lesion occurred after tumor was rescted.
  
  
  CONCLUSIONS
  Paraneoplastic pemphigus with Castleman's disease is a rare disease. The key step is to find and resect the tumor in abdomen. CT scan should be used to detect the tumor in patients with PNP, especially, when predisone was failed in treatment.
authors.affiliation: Department of General Surgery, First Hospital, Peking University, Beijing 100034, China.
authors.forename: Wen-han
authors.initials: WH
authors.lastname: Wu
authors.forename: Yin-mo
authors.initials: YM
authors.lastname: Yang
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Zhu
authors.forename: Ren-gui
authors.initials: RG
authors.lastname: Wang
authors.forename: Jun-hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Yan-ting
authors.initials: YT
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D016506:Pemphigus, Benign Familial / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D012189:Retrospective Studies