Paroxysmal cold haemoglobinuria as a tardive complication of idiopathic myelofibrosis.
Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by the Donath-Landsteiner antibody. It is classically described in association with chronic syphilis or after acute viral infections. We describe the first case of PCH presented as a late manifestation of advanced myelofibrosis associated with antiphospholipid syndrome, that promptly responded to high dosage of prednisone.
Breccia
Massimo
M
Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy. breccia@bce.uniroma1.it
D'Elia
Gianna Maria
GM
Girelli
Gabriella
G
Vaglio
Stefania
S
Gentilini
Fabiana
F
Chiara
Sarlo
S
Alimena
Giuliana
G
D000368:Aged; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000209:etiology*; D006801:Humans; D055728:Primary Myelofibrosis / Q000209:etiology*