title: Visualizing the first 50 hr of the primary immune response to a soluble antigen.
abstract: Recently, static and dynamic imaging methods have produced the first glimpses of the interactions between antigen-specific T cells and peptide-MHC-bearing antigen-presenting cells in the lymph nodes. Using data from these experiments, we produced a numerically, spatially, and temporally scaled simulation of the first 50 hr of the primary T cell-dependent immune response. The simulation highlights how lymph node structure facilitates antigen presentation to rare, naive, antigen-specific CD4+ T cells.
authors.affiliation: Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA. catro001@umn.edu
authors.forename: Drew M
authors.initials: DM
authors.lastname: Catron
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Itano
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Pape
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Mueller
authors.forename: Marc K
authors.initials: MK
authors.lastname: Jenkins
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D018715:Microscopy, Video; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*