[Study of the effect of super painkiller on the sexual function of male rats with type I diabetes].
OBJECTIVE
To study the effects of super painkiller on the sexual function of male Wistar rats with diabetes.


METHODS
Thirty-two Wistar rats at 3-5 months of age were divided into two groups at random: 22 in the diabetes group, and 10 in the control group. After 72 hours, the former was further divided into 2 subgroups: non-treatment and super painkiller treatment. In 5 weeks, blood glucose was determined. After the apomorphines experiment, the rats were killed, blood taken from the vein, homogenate prepared from the isolated testis tissue and the level of NO and NOS in the serum and tissue homogenate surveyed, separately.


RESULTS
Compared with the control group, serum NO and NOS of the diabetic rats dropped sharply. Compared with the non-treatment group, the serum NO and NOS of the super painkiller treatment group were very high and the difference was significant (P < 0.01). Apomorphine injection showed that the times of penis erection of the treated rats were more than those of the non-treatment group (P < 0.01) , but the difference was not significant compared with the control (P > 0.05).


CONCLUSIONS
Super painkiller has sure effect of reducing blood glucose, with a certain curative value for sexual and reproductive malfunction of diabetic rats.
Wang
Baixin
B
College of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang 154007, China. jmwbc@163.com
Wang
Shuqiu
S
Wang
Shuxiang
S
Gao
Yanhua
Y
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D009569:Nitric Oxide / Q000032:analysis; D019001:Nitric Oxide Synthase / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase