Effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels in the nucleus accumbens of alcohol-preferring (P) rats.
The effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels was investigated in the nucleus accumbens (NAC) of P rats. Rats were double-housed (DH) in plastic tubs, or single-housed (SH) in hanging wire cages for 12 weeks. Microdialysis in the NAC showed greater sulpiride-induced DA increases in the NAC of SH vs. DH rats, with no difference in basal levels. The data indicate that housing conditions can alter DA D(2) receptor function in the NAC.
Engleman
Eric A
EA
Department of Psychology, Institute of Psychiatric Research, Indiana University School of Medicine, Rm. M115, 791 Union Drive, Indianapolis, IN 46202, USA. eenglema@iupui.edu
Ingraham
Cynthia M
CM
O'Brien
Caryn E
CE
McBride
William J
WJ
Murphy
James M
JM
D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D019540:Area Under Curve; D001522:Behavior, Animal; D002492:Central Nervous System Depressants / Q000008:administration & dosage; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000008:administration & dosage; D005110:Extracellular Space / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006798:Housing; D006799:Housing, Animal; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013469:Sulpiride / Q000494:pharmacology*; D013997:Time Factors
D002492:Central Nervous System Depressants; D018492:Dopamine Antagonists; D000431:Ethanol; D013469:Sulpiride; D004298:Dopamine