Therapeutic manipulation of T cell chemotaxis in transplantation.
T cell migration and trafficking are regulated by the well defined cellular processes of rolling, activation, tight adhesion, arrest and diapedesis. These processes are, in turn, controlled by molecular events involving integrins, selectins, chemokines and chemokine receptors. Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are also important molecular modulators of migration and trafficking. Many of these molecules are appropriate targets for preventing allograft rejection or for achieving tolerance. Studies of migration and trafficking have also shown that the anatomic choreography of alloantigen presentation and T cell encounter with alloantigen and immunosuppression, are over-riding determinants of T cell priming versus tolerization.
Yopp
Adam C
AC
Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1104, New York, New York 10029-6574, USA.
Krieger
Nancy R
NR
Ochando
Jordi C
JC
Bromberg
Jonathan S
JS
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D049349:Receptors, Lysosphingolipid / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D015815:Cell Adhesion Molecules; D018925:Chemokines; D049349:Receptors, Lysosphingolipid