Best evidence topic report. Gastric lavage in aspirin and non-steroidal anti-inflammatory drug overdose.
A short cut review was carried out to establish whether gastric lavage was better than activated charcoal alone at reducing toxicity after aspirin or other non-steroidal anti-inflammatory drug (NSAID) overdose. Altogether 72 papers were found using the reported search, of which one presented the best evidence to answer the clinical question. A further relevant paper was found on scanning the references of papers identified. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.
Teece
Stewart
S
Department of Emergency Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
Crawford
Ian
I
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning*; D001241:Aspirin / Q000506:poisoning*; D002606:Charcoal / Q000627:therapeutic use; D004347:Drug Interactions; D062787:Drug Overdose / Q000628:therapy; D004630:Emergencies; D019317:Evidence-Based Medicine; D005260:Female; D005751:Gastric Lavage; D006801:Humans; D008875:Middle Aged; D013406:Suicide, Attempted
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002606:Charcoal; D001241:Aspirin