Transient pancytopenia preceding T lineage acute lymphoblastic leukemia.
Transient pancytopenia preceding acute lymphoblastic leukemia (pre-ALL) is a rare occurrence usually affecting children with subsequent development of B lineage ALL. We report a case of pre-ALL characterized by a T cell immunophenotype and abnormal karyotype t (11; 14) (q10; q10). The patient achieved a transient complete remission after initial therapy, but relapsed within a few months and died of leukemic encephalopathy. To the best of our knowledge, this is the first report of T lineage pre-ALL.
Zhao
Hui
H
Department of Thrombosis and Hemostasis, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, PR China.
Zhang
Li
L
Zhu
Xiaofan
X
Chen
Yumei
Y
Zou
Yao
Y
Zhang
Lei
L
Yang
Renchi
R
Han
Zhong Chao
ZC
D019070:Cell Lineage / Q000276:immunology; D002648:Child; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D010198:Pancytopenia / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D013601:T-Lymphocytes