title: Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy.
abstract: Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-1-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-alpha levels and the amelioration of clonogenic parameters.
authors.affiliation: Division of Allergy and Clinical Immunology, University of Rome La Sapienza, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Isgrò
authors.forename: Ivano
authors.initials: I
authors.lastname: Mezzaroma
authors.forename: Alessandro
authors.initials: A
authors.lastname: Aiuti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fantauzzi
authors.forename: Marcello
authors.initials: M
authors.lastname: Pinti
authors.forename: Andrea
authors.initials: A
authors.lastname: Cossarizza
authors.forename: Fernando
authors.initials: F
authors.lastname: Aiuti
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D017209:Apoptosis; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D015497:HIV-1; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology*; D006801:Humans; D019014:fas Receptor / Q000032:analysis
chemical_list: D019380:Anti-HIV Agents; D019014:fas Receptor