Effects of organotin compounds on pubertal male rats.
Tributyltin (TBT) and triphenyltin (TPT) induce effects in male and female reproductive organs of rodents. They also cause tumors in these organs and it is theorized that they result from endocrine disruption. We studied the effects of 40 mg methyltestosterone (MTT), 0.5 or 15 mg TBT and 2, 6 or 12 mg TPT/kg bw on the male sexual development using a modification of the Rodent 20-Day Thyroid/Pubertal Male Assay. Male Wistar rats were treated per gavage for 30 days beginning at 23 days of age. A delay in the completion of preputial separation was observed after administration of MTT and 15 mg/kg TBT. Changes in weights of one or more reproductive organs were observed in all treatment groups. Testosterone concentration was decreased in the MTT, the 15 mg TBT as well as in the 6 and 12 mg TPT groups. A decrease in luteinizing hormone (LH) concentration was observed in the MTT and 15 mg TBT groups while an increase was seen after exposure to 6 mg TPT/kg bw. We conclude that peripubertal exposure to 15 mg TBT and 6 mg TPT/kg bw clearly affected male sexual development.
Grote
Konstanze
K
Institute of Clinical Pharmacology and Toxicology, Charité University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany.
Stahlschmidt
Beate
B
Talsness
Chris E
CE
Gericke
Christine
C
Appel
Klaus E
KE
Chahoud
Ibrahim
I
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D005837:Genitalia, Male / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008777:Methyltestosterone / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D009947:Organotin Compounds / Q000633:toxicity*; D010413:Penis / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation / Q000187:drug effects* / Q000502:physiology; D013739:Testosterone / Q000097:blood; D018675:Toxicity Tests; D014220:Trialkyltin Compounds / Q000633:toxicity*
D004785:Environmental Pollutants; D009947:Organotin Compounds; D014220:Trialkyltin Compounds; D013739:Testosterone; C011559:tributyltin; D007986:Luteinizing Hormone; C030665:triphenyltin; D008777:Methyltestosterone