Nutrition and physical activity and chronic disease prevention: research strategies and recommendations.
A shortage of credible information exists on practical dietary and physical activity patterns that have potential to reverse the national obesity epidemic and reduce the risk of major cancers and other chronic diseases. Securing such information is a challenging task, and there is considerable diversity of opinion concerning related research designs and priorities. Here, we put forward some perspectives on useful methodology and infrastructure developments for progress in this important area, and we list high-priority research topics in the areas of 1) assessment of nutrient intake and energy expenditure; 2) development of intermediate outcome biomarkers; 3) enhancement of cohort and cross-cultural studies; and 4) criteria for and development of full-scale nutrition and physical activity intervention trials.
Prentice
Ross L
RL
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, M3-A410, Seattle, WA 98109-1024, USA. rprentic@fhcrc.org
Willett
Walter C
WC
Greenwald
Peter
P
Alberts
David
D
Bernstein
Leslie
L
Boyd
Norman F
NF
Byers
Tim
T
Clinton
Steven K
SK
Fraser
Gary
G
Freedman
Laurence
L
Hunter
David
D
Kipnis
Victor
V
Kolonel
Laurence N
LN
Kristal
Bruce S
BS
Kristal
Alan
A
Lampe
Johanna W
JW
McTiernan
Anne
A
Milner
John
J
Patterson
Ruth E
RE
Potter
John D
JD
Riboli
Elio
E
Schatzkin
Arthur
A
Yates
Allison
A
Yetley
Elizabeth
E
D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002908:Chronic Disease; D015331:Cohort Studies; D018849:Controlled Clinical Trials as Topic; D003431:Cross-Cultural Comparison; D002149:Energy Intake; D004734:Energy Metabolism; D005247:Feeding Behavior; D006801:Humans; D009043:Motor Activity; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D017063:Outcome Assessment, Health Care; D011322:Primary Prevention / Q000379:methods*; D012107:Research Design
D015415:Biomarkers