CUPpling calcium to lysosomal biogenesis.
Transport from late endosomes to lysosomes results in the formation of an endosome-lysosome hybrid organelle from which late endosomes and lysosomes must be re-formed. Recent studies indicate that the transient receptor potential (TRP)-related channel mucolipin-1 (the loss of which causes mucolipidosis type IV) and its Caenorhabditis elegans orthologue CUP-5 might control the process of lysosome re-formation by regulating calcium flux.
Piper
Robert C
RC
Department of Physiology, University of Iowa, Iowa City, IA 52242, USA. robert-piper@uiowa.edu
Luzio
J Paul
JP
D000818:Animals; D001692:Biological Transport; D017173:Caenorhabditis elegans / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D011992:Endosomes / Q000502:physiology*; D008247:Lysosomes / Q000378:metabolism / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D050053:TRPM Cation Channels; D050051:Transient Receptor Potential Channels
C426649:CUP-5 protein, C elegans; D029742:Caenorhabditis elegans Proteins; C416674:MCOLN1 protein, human; D008565:Membrane Proteins; D050053:TRPM Cation Channels; D050051:Transient Receptor Potential Channels; D002118:Calcium