[Comparative assessment of cell mechanisms of the antidiabetic action of a new organic derivative of oxovanadium(IV) and vanadyl sulfate].
The antidiabetic effect of a new organic derivative of vanadium(IV) oxide with isonicotinic acid hydrazide (compound no. 8), as manifested by the action upon the alpha and beta cell populations in Langerhans islands of the pancreas, was studied in rats with alloxane diabetes model in comparison to the analogous effect of the inorganic drug vanadyl sulfate. The hypoglycemic activity of compound no. 8 was comparable with that of vanadyl sulfate. The results of immunohistochemical and morphometric investigation showed that both preparations produced a reliable increase in the population of insulin-producing cells and a decrease in the (alloxane-enhanced) population of alpha-cells in the pancreatic islands.
Aleeva
G N
GN
Kiiasov
A P
AP
Burykin
I M
IM
Khafiz'ianova
R Kh
RKh
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology; D005934:Glucagon / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007150:Immunohistochemistry; D007328:Insulin / Q000378:metabolism; D007538:Isoniazid / Q000737:chemistry; D007801:Langerhans Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051381:Rats; D014638:Vanadates / Q000737:chemistry / Q000494:pharmacology*; D017968:Vanadium Compounds / Q000494:pharmacology*
D007004:Hypoglycemic Agents; D007328:Insulin; D017968:Vanadium Compounds; C075743:oxovanadium IV; D014638:Vanadates; C034028:vanadyl sulfate; D005934:Glucagon; D007538:Isoniazid