Novel tetrahydro-thieno pyridyl oxazolidinone: an antibacterial agent.
Synthesis of a number of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine substituted oxazolidinones have been reported. They have been screened against a panel of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. A SAR has been developed. Compound 15 showed comparable activity (MIC) to linezolid and superior to eperezolid.
Lohray
Braj Bhushan
BB
Zydus Research Centre, Cadila Healthcare Ltd, Sarkhej-Bavla N. H.8 A, Moraiya, Ahmedabad 382210, India. braj.lohray@zyduscadila.com
Lohray
Vidya Bhushan
VB
Srivastava
Brijesh Kumar
BK
Kapadnis
Prashant B
PB
Pandya
Purvi
P
D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects*; D000069349:Linezolid; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D023303:Oxazolidinones / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000494:pharmacology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D010080:Oxazoles; D023303:Oxazolidinones; D011725:Pyridines; C502706:tetrahydro-thieno pyridyl oxazolidinone; D014640:Vancomycin; C098011:eperezolid; D000069349:Linezolid; D008712:Methicillin