title: Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa.
abstract: A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822-2275, USA. ayocha@mail.ecc.u-tokyo.ac.jp
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Wesley Y
authors.initials: WY
authors.lastname: Yoshida
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Takada
authors.forename: Junji
authors.initials: J
authors.lastname: Kimura
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.forename: Susan L
authors.initials: SL
authors.lastname: Mooberry
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Scheuer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D004354:Drug Screening Assays, Antitumor; D006254:Hawaii; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D008974:Mollusca; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C492405:kulokekahilide-2