[Traumatic optic neuropathy--the present state].
Direct or indirect trauma may damage the optic nerve and result in permanent visual loss. The diagnosis of traumatic optic neuropathy is not always straightforward and is complicated by unfavourable circumstances for the examination. The diagnosis should only by established if it can be based on a clear objective finding, a relative afferent pupillary defect or a pathological flash-evoked visual response. Concerning therapy, surgical decompression (even without direct injury to the nerve) or megadose steroids or both in combination have been recommended. But even spontaneous improvement may occur. A large multicentre study could not demonstrate a significant advantage for any of the measures recommended, not even against the spontaneous course. However, the study was not randomised. In animal experiments steroids have shown an unfavourable effect. Currently, therapeutic decisions have to be made on an individual basis, in the absence of any evidence-based recommendations.
Wilhelm
H
H
Universitäts-Augenklinik, Tübingen.
D000818:Animals; D019299:Decompression, Surgical / Q000379:methods*; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use; D019635:Neurosurgical Procedures / Q000379:methods*; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000628:therapy; D020221:Optic Nerve Injuries / Q000175:diagnosis* / Q000628:therapy*; D013256:Steroids / Q000627:therapeutic use*; D016896:Treatment Outcome
D018696:Neuroprotective Agents; D013256:Steroids