title: Mechanics and hemodynamics of esophageal varices during peristaltic contraction.
abstract: Our hypothesis states that variceal pressure and wall tension increase dramatically during esophageal peristaltic contractions. This increase in pressure and wall tension is a natural consequence of the anatomy and physiology of the esophagus and of the esophageal venous plexus. The purpose of this study was to evaluate variceal hemodynamics during peristaltic contraction. A simultaneous ultrasound probe and manometry catheter was placed in the distal esophagus in nine patients with esophageal varices. Simultaneous esophageal luminal pressure and ultrasound images of varices were recorded during peristaltic contraction. Maximum variceal cross-sectional area and esophageal luminal pressures at which the varix flattened, closed, and opened were measured. The esophageal lumen pressure equals the intravariceal pressure at variceal flattening due to force balance laws. The mean flattening pressures (40.11 +/- 16.77 mmHg) were significantly higher than the mean opening pressures (11.56 +/- 25.56 mmHg) (P < or = 0.0001). Flattening pressures >80 mmHg were generated during peristaltic contractions in 15.5% of the swallows. Variceal cross-sectional area increased a mean of 41% above baseline (range 7-89%, P < 0.0001) during swallowing. The peak closing pressures in patients that experience future variceal bleeding were significantly higher than the peak closing pressures in patients that did not experience variceal bleeding (P < 0.04). Patients with a mean peak closing pressure >61 mmHg were more likely to bleed. In this study, accuracy of predicting future variceal bleeding, based on these criteria, was 100%. Variceal models were developed, and it was demonstrated that during peristaltic contraction there was a significant increase in intravariceal pressure over baseline intravariceal pressure and that the peak intravariceal pressures were directly proportional to the resistance at the gastroesophageal junction. In conclusion, esophageal peristalsis in combination with high resistance to blood flow through the gastroesophageal junction leads to distension of the esophageal varices and an increase in intravariceal pressure and wall tension.
authors.affiliation: Dept. of Gastroenterology, Temple Univ. Hospital, 3401 North Broad St., Philadelphia, PA 19140, USA.
authors.forename: Larry S
authors.initials: LS
authors.lastname: Miller
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Kim
authors.forename: Qing
authors.initials: Q
authors.lastname: Dai
authors.forename: Jyothi
authors.initials: J
authors.lastname: Mekapati
authors.forename: James
authors.initials: J
authors.lastname: Izanec
authors.forename: Chan
authors.initials: C
authors.lastname: Chung
authors.forename: Ji-Bin
authors.initials: JB
authors.lastname: Liu
authors.forename: Andrew
authors.initials: A
authors.lastname: Sanderson
authors.forename: Matt
authors.initials: M
authors.lastname: Bohning
authors.forename: Josh
authors.initials: J
authors.lastname: Desipio
authors.forename: Jasneet
authors.initials: J
authors.lastname: Gandegok
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Harberson
authors.forename: Carson
authors.initials: C
authors.lastname: Schneck
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nicosia
authors.forename: Vinod
authors.initials: V
authors.lastname: Thangada
authors.forename: Beje
authors.initials: B
authors.lastname: Thomas
authors.forename: Brian
authors.initials: B
authors.lastname: Copeland
authors.forename: Elan
authors.initials: E
authors.lastname: Miller
authors.forename: Aaron
authors.initials: A
authors.lastname: Miller
authors.forename: Naji
authors.initials: N
authors.lastname: Ahmed
authors.forename: James G
authors.initials: JG
authors.lastname: Brasseur
mesh_terms: D000328:Adult; D003679:Deglutition; D004932:Esophageal and Gastric Varices / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004947:Esophagus / Q000098:blood supply* / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008953:Models, Anatomic; D009119:Muscle Contraction / Q000502:physiology*; D010528:Peristalsis / Q000502:physiology*; D011312:Pressure; D014463:Ultrasonography