[KatG Ser3 15Thr mutation as the main reason of isoniazid resistance in Mycobacterium tuberculosis isolated in the Novosibirsk and Kemerovo Regions].
KatG Ser3 15Thr mutation is one of the main reasons of resistance to isoniazid in Mycobacterium tuberculosis isolates. The frequency rate of the above mutation among isoniazid-resistant isolates made 94% in Novosibirsk Region and 93% in Kemerovo Region. The use of PCR-restriction fragment length polymorphism (PCR-RFLP) can be regarded as an adequate method for rapid screening of isoniazid resistance in Mycobacterium tuberculosis isolated in the West-Siberian Region.
Voronina
E N
EN
Vikhrova
M A
MA
Khrapov
E A
EA
Kinsht
V N
VN
Norkina
O V
OV
Gorbunova
E V
EV
Shabaldin
A V
AV
Glushkov
A N
AN
Krasnov
V A
VA
Filipenko
M L
ML
D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D000995:Antitubercular Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D002374:Catalase / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008875:Middle Aged; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D012694:Serine; D012800:Siberia; D013912:Threonine
D000995:Antitubercular Agents; D001426:Bacterial Proteins; D013912:Threonine; D012694:Serine; D002374:Catalase; C480353:katG protein, Mycobacterium tuberculosis; D007538:Isoniazid