The effect of indocyanine green pretreatment on the parameters of transscleral diode laser thermotherapy-induced threshold coagulation of the ciliary body.
OBJECTIVE
To study the effect of indocyanine green (ICG) pretreatment on threshold parameters of transscleral diode laser thermotherapy-induced threshold coagulation of the ciliary body. The procedure was termed 'cyclothermotherapy' based on the long duration (15-60 seconds) of diode laser application.


METHODS
The right eyes of nine young adult New Zealand white rabbits underwent transscleral cyclothermotherapy (TCT, Group 1), TCT following ICG pretreatment (Group 2), and external manipulation of the ciliary body alone (Group 3). Rabbits were sacrificed after 24 hours; specimens were evaluated with gross examination and light microscopy.


RESULTS
Thresholds were 30 J/cm2 (TCT) and 4.5 J/cm2 (TCT with ICG). Widespread structural damage was seen in the ciliary processes and the ciliary body in Groups 1 and 2. In Group 3, external manipulation of the ciliary body caused hemorrhage and structural damage confined to the ciliary processes.


CONCLUSIONS
ICG pretreatment reduced the energy necessary to cause a threshold lesion with TCT in nonpigmented rabbits.
Kuo
Po-Cheng
PC
The Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Peyman
Gholam A
GA
Men
Gamze
G
Bezerra
Yanno
Y
Torres
Franco
F
D000818:Animals; D002924:Ciliary Body / Q000187:drug effects / Q000601:surgery*; D007208:Indocyanine Green / Q000494:pharmacology*; D017075:Laser Coagulation; D011300:Preoperative Care; D011817:Rabbits
D007208:Indocyanine Green