title: Anatomical functional changes in a patient presenting a complex malformation of cortical development.
abstract: The authors describe a case of right fronto-parietal micropoligyria associated with small schizencephaly clefts and the presence of a frontal open-lip schizencephaly with corpus callosum agenesis. A functional magnetic resonance imaging (fMRI) study was performed to evaluate the possible reorganization of cortical functions in a patient presenting a complex malformation pattern and to investigate which cortical areas were activated during left finger movements. An fMRI study was performed during the execution of a repetitive index finger-to-thumb opposition movement with the right hand and the left hand in 2 separate sessions. Movement of the right hand induced a normal motor activation pattern involving the contralateral left sensory-motor cortex. Movement of the left hand produced significant activation of brain cortex. This fMRI study highlights the compensatory role of the ipsilateral cortical pathways in hand movements in the case of a complex brain malformation that involves the main motor activation areas.
authors.affiliation: Department of Neurological Sciences, University of Rome La Sapienza, 00185 Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Calistri
authors.forename: Delia
authors.initials: D
authors.lastname: Lenzi
authors.forename: Francesca
authors.initials: F
authors.lastname: Gilio
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Bonaventura
authors.forename: Maurizio
authors.initials: M
authors.lastname: Inghilleri
authors.forename: Caterina
authors.initials: C
authors.lastname: Mainero
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pantano
mesh_terms: D061085:Agenesis of Corpus Callosum; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013003:Somatosensory Cortex / Q000002:abnormalities*
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA