Microstimulation of V1 input layers disrupts the selection and detection of visual targets by monkeys.
Electrical microstimulation delivered to primary visual cortex (V1) concurrently with the presentation of visual targets interferes with the selection of these targets. To determine the source of this interference, we stimulated the visual input layers of V1 as rhesus monkeys generated saccadic eye movements to visual targets presented at and outside the receptive field of the stimulated neurons. Columns of cells in V1 innervated by the left and right eye are segregated according to eye dominance, such that cells within a column respond best to visual stimuli presented to the ocular dominant eye. Interference was maximal when targets were presented to the ocular dominant eye, moderate when presented to the ocular inferior eye, and negligible when presented to both eyes. Thus, electrical microstimulation of the visual input layers of V1 disrupts the flow of visual information along the geniculostriate pathway. Knowing how electrical stimulation of V1 affects visual behaviour is necessary when using monkeys to develop a visual prosthesis for the blind.
Slocum
Warren M
WM
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, E25-634, Cambridge, MA 02139, USA. wmslocum@mit.edu
Tehovnik
Edward J
EJ
D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D001522:Behavior, Animal; D001931:Brain Mapping; D023882:Dominance, Ocular / Q000502:physiology; D004558:Electric Stimulation / Q000379:methods*; D008253:Macaca mulatta; D008839:Microelectrodes; D012438:Saccades / Q000502:physiology / Q000528:radiation effects*; D014793:Visual Cortex / Q000502:physiology / Q000528:radiation effects*; D014794:Visual Fields / Q000502:physiology / Q000528:radiation effects*