[Antiremodeling Activity of Nebivolol in Patients With Essential Hypertension and Various Types of 4a/4b Polymorphisms of Endothelial NO Synthase Gene].
Frequencies of alleles and genotypes of a polymorphic marker 4a/4b of eNOS gene and association of this marker with parameters of hemodynamics, signs of left ventricular hypertrophy and endothelial dysfunction were studied in 78 uzbek men aged 50.5+/-9.5 years with stage I-II essential hypertension. Allele 4b and genotype 4b/4b were found to be most frequent while genotypes 4a/4b and 4a/4a were associated with high degree of left ventricular hypertrophy, disturbances of 24-hour blood pressure profile and pronounced diastolic dysfunction. Three months of therapy with nebivolol exerted similar antihypertensive effect in all patients however only in patients with 4b/4b genotype it caused regression of left ventricular hypertrophy and normalization of endothelial vasoregulatory function.
Karimova
I A
IA
National Research Special Cardiology Center, Institute of Genetics and Experimental Biology of Uzbekistan Republic, Tashkent.
Eliseeva
M R
MR
Karimova
B Sh
BSh
Abdullaeva
G Zh
GZh
Adylov
B Sh
BSh
D005838:Genotype; D006801:Humans; D006973:Hypertension; D017379:Hypertrophy, Left Ventricular; D000068577:Nebivolol; D011110:Polymorphism, Genetic
D000068577:Nebivolol