title: Langerhans cell histiocytosis presenting as a limbal nodule in an adult patient.
abstract: OBJECTIVE
  To report a case of Langerhans cell histiocytosis presenting as a limbal nodule.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A 26-year-old man presented with a superior limbal mass. On clinical examination, an infiltrative/neoplastic lesion was suspected, and a differential diagnosis of limbal amyloidosis, limbal fibrous histiocytoma, lymphoma, and juvenile xanthogranuloma was made. There was no other associated ocular or systemic abnormality. An excision biopsy was performed.
  
  
  RESULTS
  The histopathology and immunohistochemical staining examination established the diagnosis of limbal Langerhans cell histiocytosis.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is an unusual presentation of Langerhans cell histiocytosis, and although rare, Langerhans cell histiocytosis should be included in the differential diagnosis of a limbal mass.
authors.affiliation: Cornea and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Tishu
authors.initials: T
authors.lastname: Saxena
authors.forename: Krishna
authors.initials: K
authors.lastname: Kumar
authors.forename: Seema
authors.initials: S
authors.lastname: Sen
authors.forename: Radhika
authors.initials: R
authors.lastname: Tandon
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003316:Corneal Diseases / Q000175:diagnosis* / Q000378:metabolism; D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016850:Limbus Corneae / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D015415:Biomarkers; D009418:S100 Proteins