[The gene expression of Th1/Th2 cytokines and its role in hypopharyngeal carcinoma].
OBJECTIVE
To observe the mRNA expression of Th1/Th2 cytokines in hypopharyngeal neoplasms and to explore the pathogenesis of it.


METHODS
The gene expression of Th1/Th2 cytokines in patients with hypopharyngeal neoplasms was detected by RT-PCR.


RESULTS
The cytokines expression of Th2 was significantly stronger than Th1 in tissue of hypopharyngeal carcinoma.


CONCLUSIONS
The dominant expression of Th2 cytokines in hypopharyngeal neoplasms may inhibit the human immunity and enhance the growth and metastasis of hypopharyngeal carcinoma.
Chen
Xuemei
X
Department of Otolaryngology, the Second Affiliated Hospital of Shandong University, Jinan, 250033, China.
Xu
Xiaoqun
X
Zhao
Jiandong
J
Zhu
Li
L
Xue
Aiying
A
Zhang
Daliang
D
D000368:Aged; D005260:Female; D015870:Gene Expression; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology*; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D015847:Interleukin-4 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*
D012333:RNA, Messenger; D016753:Interleukin-10; D015847:Interleukin-4