[Correlation between TXB2, 6-Keto-PGF1alpha and liver metastasis in rats model with blood stasis].
OBJECTIVE
To observe the correlation between serum level of TXB2, 6-Keto-PGF1alpha and liver metastasis.


METHODS
The metastatic model was made by injection of W256 carcinosarcoma. Rats were randomly divided into two groups: rats with blood stasis group and control group. Rats in control group were given normal saline via abdominal cavity once a day. Rats in blood stasis group were injected adrenalin in the fourteenth day. Tumor size and liver metastasis were observed. Serum TXB2 and 6-Keto-PGF1alpha were tested by radioimmunoassay.


RESULTS
Tumor size in rats with blood stasis was significantly smaller than that of the control group (P<0.01). Occurrence of liver metastasis in rats with blood stasis was significantly lower than that of the control group (P<0.01). The values of 6-Keto-PGF1alpha, TXB2, and TXB2/6-Keto-PGF1alpha were higher in the group with blood stasis.


CONCLUSIONS
In the status of blood stasis, W256 carcinosarcoma grows slowly, and liver metastasis increases insignificantly, with the elevations of 6-Keto-PGF1alpha, TXB2 and TXB2/6-Keto-PGF1alpha.
Chen
Zhen
Z
Department of Traditional Chinese Medicine, Cancer Hospital, Fudan University, Shanghai 200032, China. chenzhen100@sohu.com
Liu
Lu-Ming
LM
He
Yi-Bei
YB
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D002296:Carcinosarcoma / Q000473:pathology; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000556:secondary*; D008297:Male; D008516:Medicine, Chinese Traditional / Q000592:standards*; D051381:Rats; D017208:Rats, Wistar; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha