Pericardial synovial sarcoma: 14-year survival with multimodality therapy.
We report a case of recurrent primary synovial sarcoma of the pericardium. Reverse transcriptase-polymerase chain reaction analysis for t(X,18) demonstrated the presence of the chimeric transcript SYT/SSX. Because of the rarity of this entity, optimal therapy is unknown. The prognosis of this tumor is very poor in previous reports. In this report, we present a case with five recurrences treated by a combination of surgery, chemotherapy, and radiotherapy. The patient survives now for more than 14 years, the longest reported survival of a primary synovial sarcoma of the pericardium.
Van der Mieren
Gerry
G
Department of Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium.
Willems
Stefan
S
Sciot
Raf
R
Dumez
Herlinde
H
Van Oosterom
Allan
A
Flameng
Willem
W
Herijgers
Paul
P
D000328:Adult; D017024:Chemotherapy, Adjuvant; D004117:Dimethoate / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007546:Isoquinolines / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000628:therapy*; D018365:Neoplasm, Residual / Q000188:drug therapy / Q000601:surgery; D010166:Palliative Care; D010496:Pericardium / Q000000981:diagnostic imaging; D013584:Sarcoma, Synovial / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D007546:Isoquinolines; C100350:ecteinascidin 729; D004317:Doxorubicin; D007069:Ifosfamide; D004117:Dimethoate