title: Quantitative analysis of polyethylene wear debris, wear rate and head damage in retrieved Charnley hip prostheses.
abstract: Submicrometer- and micrometer-sized ultra-high molecular weight polyethylene (UHMWPE) wear particles have been associated with osteolysis and failure of total artificial joints. Previous studies have isolated predominantly submicrometer-sized particles at the expense of larger particles (>10 microm). This study aimed to isolate and characterize quantitatively all sizes of UHMWPE wear particles generated in 18 Charnley hip prostheses. In addition, to analyze the wear debris with respect to the total volumetric wear of the cup and damage to the femoral head. Particle size distributions ranged from 0.1 to ->1000 microm. A significant proportion (3-82%) of the mass of the wear debris isolated was>10 microm. The mode of the frequency distribution of the particles was in the range 0.1-0.5 microm for all patients. However, analysis of the mass of wear debris as a function of its size allowed differentiation of the wear debris from different patients. Femoral head damage was associated with high volumetric wear and increased numbers of biologically active submicrometer-sized particles.
authors.affiliation: Department of Microbiology, University of Leeds, Leeds, LS2 9JT, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Tipper
authors.forename: E
authors.initials: E
authors.lastname: Ingham
authors.forename: J L
authors.initials: JL
authors.lastname: Hailey
authors.forename: A A
authors.initials: AA
authors.lastname: Besong
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.forename: B M
authors.initials: BM
authors.lastname: Wroblewski
authors.forename: M H
authors.initials: MH
authors.lastname: Stone