title: [Evaluation of varicella complications through a retrospective hospital survey in a paediatric center over 16 years in France].
abstract: OBJECTIVE
  Evaluation of the varicella severity through a prevalence study of hospital admissions justified by a complication directly related to the onset of an acute episode of varicella.
  
  
  METHODS
  Retrospective study in one paediatric center in France with a follow-up of a paediatric cohort from April 1987 to December 2002. This general paediatric hospital recruits children from a 400,000 inhabitants area. Inclusion criterion: diagnosis main or associated of varicella.
  
  
  METHODS
  congenital or acquired immunodepression, including long-term oral high dosage steroid therapy.
  
  
  RESULTS
  Three hundred and forty-three (343) complications of varicella were reported in 309 children hospitalised for a symptom in relationship with varicella. Most of children (75%) were <2 years of age. The annual number of hospitalisations varied with a maximum of 44. An increase of the number of hospitalisations was reported since 1997 but particularly since 2000. Main complications were gastro-intestinal (75), neurological (68), bronchopulmonary (52), and skin and soft tissue infections (52). Superinfections of soft tissues such as Streptococcus pyogenes cellulitis and life-threatening complications, which occurred in children treated by a short-course of corticosteroïds for an acute episode such as an asthma crisis, were mostly noticed since 1995. Two deaths occurred.
  
  
  CONCLUSIONS
  These data collected over 16 years as part of a retrospective survey of a paediatric cohort show that varicella, often considered as a mild disease, can be responsible for severe complications in young immunocompetent children. The digestive complications (30%) are the main complication in our study with existence of gingivitis-stomatitis but also lower digestive manifestations (erosive gastritis aspect through endoscopy). These data have all the more to be taken into account because a vaccine, developed for healthy children, is now available in France. A national survey of hospitalised varicella has been set up since March 2003.
authors.affiliation: Département de pédiatrie médicale, centre hospitalier universitaire Charles-Nicolle, Rouen, France. eric.mallet@chu-rouen.fr <eric.mallet@chu-rouen.fr>
authors.forename: E
authors.initials: E
authors.lastname: Mallet
authors.forename: M
authors.initials: M
authors.lastname: Maitre
authors.forename: L
authors.initials: L
authors.lastname: Delalande-Dutilleul
authors.forename: C
authors.initials: C
authors.lastname: Marguet
authors.forename: O
authors.initials: O
authors.lastname: Mouterde
mesh_terms: D000293:Adolescent; D002644:Chickenpox / Q000150:complications* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005602:France; D006760:Hospitalization; D006761:Hospitals; D006801:Humans; D007223:Infant; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors