title: Improved procedure for the oxidative cleavage of olefins by OsO4-NaIO4.
abstract: [reaction: see text] Oxidative cleavage of olefins by OsO(4)-NaIO(4) sometimes suffers from low yields due to the formation of side products. It is found that the addition of 2,6-lutidine can suppress the side reactions and dramatically improve the yield of this classic reaction.
authors.affiliation: Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yu
authors.forename: Yan
authors.initials: Y
authors.lastname: Mei
authors.forename: Ying
authors.initials: Y
authors.lastname: Kang
authors.forename: Zhengmao
authors.initials: Z
authors.lastname: Hua
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Jin
mesh_terms: D000447:Aldehydes / Q000032:analysis / Q000138:chemical synthesis*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D007452:Iodates / Q000737:chemistry; D015394:Molecular Structure; D017892:Osmium Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000475:Alkenes; D007452:Iodates; D017892:Osmium Compounds; D011725:Pyridines; C013093:2,6-lutidine; C032285:sodium iodate