Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy.
A dysfunction of amino acid neurotransmitter transporters occurs in a number of central nervous system disorders, including stroke, epilepsy, cerebral palsy and amyotrophic lateral sclerosis. This dysfunction can comprise a reversal of transport direction, leading to the release of neurotransmitter into the extracellular space, or an alteration in transporter expression level. This review analyses the role of glutamate and GABA transporters in the pathogenesis and therapy of a number of acute and chronic neurological disorders.
Allen
Nicola J
NJ
Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK.
Káradóttir
Ragnhildur
R
Attwell
David
D
D000208:Acute Disease; D000818:Animals; D002493:Central Nervous System Diseases / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D002908:Chronic Disease; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid