title: Dynamic infrared imaging for the detection of malignancy.
abstract: The potential for malignancy detection using dynamic infrared imaging (DIRI) has been investigated in an animal model of human malignancy. Malignancy was apparent in images formed at the vasomotor and cardiogenic frequencies of tumour bearing mice. The observation of malignancy was removed by the administration of an agent that blocks vasodilation caused by nitric oxide (NO). Image patterns similar to those that characterize malignancy could be mimicked in normal mice using an NO producing agent. Apparently DIRI allows for cancer detection in this model through vasodilation caused by malignancy generated NO. Dynamic infrared detection of vasomotor and cardiogenic surface perfusion was validated in human subjects by a comparison with laser Doppler flowmetry (LDF). Dynamic infrared imaging technology was then applied to breast cancer detection. It is shown that dynamic infrared images formed at the vasomotor and cardiogenic frequencies of the normal and malignant breast have image pattern differences, which may allow for breast cancer detection.
authors.affiliation: Department of Radiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA. tbutton@radiol.som.sunysb.edu
authors.forename: Terry M
authors.initials: TM
authors.lastname: Button
authors.forename: Haifang
authors.initials: H
authors.lastname: Li
authors.forename: Paul
authors.initials: P
authors.lastname: Fisher
authors.forename: Ruth
authors.initials: R
authors.lastname: Rosenblatt
authors.forename: Khaldoon
authors.initials: K
authors.lastname: Dulaimy
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Brian
authors.initials: B
authors.lastname: O'Hea
authors.forename: Mathew
authors.initials: M
authors.lastname: Salvitti
authors.forename: Veronica
authors.initials: V
authors.lastname: Geronimo
authors.forename: Christine
authors.initials: C
authors.lastname: Geronimo
authors.forename: Sachin
authors.initials: S
authors.lastname: Jambawalikar
authors.forename: Paola
authors.initials: P
authors.lastname: Carvelli
authors.forename: Richard
authors.initials: R
authors.lastname: Weiss
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017078:Laser-Doppler Flowmetry; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D005996:Nitroglycerin / Q000494:pharmacology; D010477:Perfusion; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013997:Time Factors
chemical_list: D009569:Nitric Oxide; D005996:Nitroglycerin