title: The influence of diabetes mellitus on plaque volume and vessel size in patients undergoing percutaneous coronary intervention.
abstract: We evaluated the influence of diabetes on plaque volume and vessel size at a reference segment in diabetic patients undergoing percutaneous coronary intervention using both angiograms and quantitative intravascular ultrasound. A total of 344 patients with 449 de novo coronary lesions including 97 diabetics (133 lesions) who underwent elective percutaneous coronary intervention under intravascular ultrasound guidance were included in this study. Eleven diabetic patients (19 lesions) received insulin and 52 patients (77 lesions) oral hypoglycemic drugs. The other 34 patients (37 lesions) received diet/exercise therapy alone. We measured vessel area (VA) and lumen area (LA) at proximal and distal reference segments by intravascular ultrasound, which were averaged. Plaque area (VA-LA) and % plaque area (100 x plaque area/VA) were subsequently calculated. Although VA was similar between diabetic and non-diabetic patients (13.46 +/- 4.49 mm2 in diabetics versus 14.11 +/- 5.24 mm2 in non-diabetics, P = 0.214), LA was smaller (6.51 +/- 2.63 mm2 versus 7.38 +/- 3.08 mm2, P = 0.004) and % PA was larger (50.4 +/- 11.7 versus 46.5 +/- 11.3, P < 0.001) in diabetic patients, especially the group receiving a hypoglycemic drug or insulin. VA, LA, and % PA were similar between patients with and without insulin treatment. These results potentially might cause undersized device selection without intravascular ultrasound guidance.
authors.affiliation: Division of Cardiovascular Medicine, Toyohashi Heart Center, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
authors.forename: Shigenori
authors.initials: S
authors.lastname: Ito
authors.forename: Takahiko
authors.initials: T
authors.lastname: Suzuki
authors.forename: Osamu
authors.initials: O
authors.lastname: Katoh
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ojio
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Sato
authors.forename: Mariko
authors.initials: M
authors.lastname: Ehara
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Masafumi
authors.initials: M
authors.lastname: Myoishi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawase
authors.forename: Ryohei
authors.initials: R
authors.lastname: Kurokawa
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Koyo
authors.initials: K
authors.lastname: Sato
authors.forename: Junji
authors.initials: J
authors.lastname: Toyama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fukutomi
authors.forename: Makoto
authors.initials: M
authors.lastname: Itoh
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D001837:Body Weights and Measures / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D048909:Diabetes Complications; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019919:Prosthesis Implantation / Q000379:methods; D015607:Stents; D018084:Ultrasonography, Interventional / Q000379:methods*