Cocaine-induced renal disease.
Cocaine has anaesthetic, vasoconstrictive and CNS stimulatory effects. Presently, it is used clinically as a local anaesthetic and abused as a recreational drug. It has been implicated in both acute and chronic renal failure and has been reported to affect every aspect of the nephron. This article will review the spectrum of cocaine-induced kidney disease and attempt to give insight into the pathophysiological mechanisms involved.
Gitman
Michael D
MD
Long Island Jewish Medical Center, Division of Kidney Diseases and Hypertension, 410 Lakeville Road, 207 New Hyde Park, New York, NY11042, USA.
Singhal
Pravin C
PC
D058186:Acute Kidney Injury / Q000139:chemically induced; D000779:Anesthetics, Local / Q000009:adverse effects; D000818:Animals; D001161:Arteriosclerosis / Q000139:chemically induced; D003042:Cocaine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000150:complications; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000502:physiology; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007238:Infarction / Q000139:chemically induced; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced*; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D008297:Male; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins / Q000037:antagonists & inhibitors; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors; D015539:Platelet Activation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012077:Renal Artery / Q000187:drug effects; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000150:complications
D000779:Anesthetics, Local; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D003042:Cocaine; D004298:Dopamine