title: Management of hand-foot syndrome in patients treated with capecitabine (Xeloda).
abstract: Comparative trials of capecitabine (Xeloda) versus 5-FU/LV in metastatic colorectal cancer have shown that hand-foot syndrome (HFS) was the only clinical adverse event occurring more frequently with capecitabine. Most patients with HFS present with dysesthesia, usually with a tingling sensation in the palms and soles of the hands and feet. This can progress in 3-4 days to burning pain plus well-defined symmetric swelling and erythema. The hands tend to be more commonly affected than the feet, and might even be the only area affected in some patients. HFS can interfere with the general activities of daily living, especially when blistering, moist desquamation, severe pain or ulceration occurs. While HFS is manageable, if ignored it can progress rapidly. However, dose interruption and reduction of capecitabine usually leads to a rapid reversal of signs and symptoms without long-term consequences. Nurses play a key role in educating patients how to recognise HFS, when to interrupt treatment and how to adjust the dose to maintain effective therapy with capecitabine over the long term. It is particularly important that patients and nurses are aware that dose interruption/reduction does not affect the overall antitumour efficacy of capecitabine.
authors.affiliation: Clinical Protocol Administration, MD Anderson Cancer Center, 1515 Holcombe Unit 426, Houston, TX 77030, USA. ylassere@mdanderson.org
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Lassere
authors.forename: Paulo
authors.initials: P
authors.lastname: Hoff
mesh_terms: D000203:Activities of Daily Living; D000465:Algorithms; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000556:secondary; D003663:Decision Trees; D003841:Deoxycytidine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D018450:Disease Progression; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D005472:Fluorouracil / Q000031:analogs & derivatives; D005528:Foot; D006225:Hand; D006801:Humans; D024802:Nurse's Role; D009730:Nursing Assessment; D009859:Oncology Nursing / Q000458:organization & administration; D010292:Paresthesia / Q000139:chemically induced / Q000451:nursing / Q000517:prevention & control; D010353:Patient Education as Topic; D011322:Primary Prevention; D012720:Severity of Illness Index; D017592:Skin Care; D013577:Syndrome
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil