Examination of the reactivity of hydroxy groups in multioxygenated cyclohexanoids: synthetic study toward cytotoxic pericosine B.
The reactivity of two hydroxy groups in some multioxygenated cyclohexanoids was examined for basic study of the synthesis of the cytotoxic marine natural product pericosine B and related compounds. Differences in reactivity for O-methylation or O-acylation among substrates were observed.
Usami
Yoshihide
Y
Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, Japan. usami@gly.oups.ac.jp
Numata
Atsushi
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012765:Shikimic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; C496390:methyl 3,4-O-isopropylidene-6-epishikimate; C496389:pericosine B; D012765:Shikimic Acid