title: Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity.
abstract: Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.
authors.affiliation: College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, 151-742, South Korea.
authors.forename: Dong-Yun
authors.initials: DY
authors.lastname: Shin
authors.forename: Sun Nam
authors.initials: SN
authors.lastname: Kim
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Chae
authors.forename: Soon-Sil
authors.initials: SS
authors.lastname: Hyun
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Seo
authors.forename: Yong-Sil
authors.initials: YS
authors.lastname: Lee
authors.forename: Kwang-Ok
authors.initials: KO
authors.lastname: Lee
authors.forename: Seok-Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Yun-Sang
authors.initials: YS
authors.lastname: Lee
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Jeong
authors.forename: Nam-Song
authors.initials: NS
authors.lastname: Choi
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D016106:Methicillin Resistance / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; D012717:Sesquiterpenes; C496018:mansonone F