title: Efficacy of albendazole in giardiasis.
abstract: Albendazole and metronidazole were compared in 68 patients diagnosed positive for giardiasis. Albendazole 1200 mg, one dose was given to 24 patients, albendazole 400 mg twice a day for 3 days was given to 23 patients, and metronidazole 400 mg 3 times a day for 5 days to 21 patients. Response to therapy was monitored by clinical examination and analysis of fresh faecal samples on days 0, 3, 7 and 10. Response to the single dose of albendazole was 55%, to the divided dose of albendazole 70%, and to metronidazole 84%. The results show that albendazole, originally recommended for helminthic infection, can also be used in patients with mixed protozoal infection or for infections resistant to metronidazole.
authors.affiliation: Pakistan Medical Research Council Research Centre, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
authors.forename: R
authors.initials: R
authors.lastname: Baqai
authors.forename: S J
authors.initials: SJ
authors.lastname: Zuberi
authors.forename: H
authors.initials: H
authors.lastname: Qureshi
authors.forename: W
authors.initials: W
authors.lastname: Ahmed
authors.forename: S
authors.initials: S
authors.lastname: Hafiz
mesh_terms: D015746:Abdominal Pain / Q000469:parasitology; D000293:Adolescent; D000328:Adult; D000368:Aged; D015766:Albendazole / Q000494:pharmacology / Q000627:therapeutic use*; D000855:Anorexia / Q000469:parasitology; D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003967:Diarrhea / Q000469:parasitology; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005243:Feces / Q000469:parasitology; D005260:Female; D005414:Flatulence / Q000469:parasitology; D005873:Giardiasis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009325:Nausea / Q000469:parasitology; D010154:Pakistan / Q000453:epidemiology; D010270:Parasite Egg Count; D016896:Treatment Outcome; D014839:Vomiting / Q000469:parasitology
chemical_list: D000981:Antiprotozoal Agents; D008795:Metronidazole; D015766:Albendazole