Public, private and non-specific antibodies induced by non-cytopathic viral infections.
Lymphocytic choriomeningitis virus (LCMV) represents a useful experimental model of murine infection with a non-cytopathic virus, bearing resemblance to HIV and hepatitis C virus (HCV) infections in humans. Recent data from the LCMV model indicate that the humoral immune response that is induced by non-cytopathic viruses is far more complex than previously appreciated. LCMV-induced IgG production is largely polyclonal, with more than 90% of the antibody repertoire constituting non-relevant specificities. A delayed virus-neutralizing antibody response is induced, including specificities directed not only against the parental LCMV-strain present in the host but also cross-specifically against LCMV-variants isolated from other hosts. These findings provide novel insights to aid our understanding of clinically relevant observations that are recorded following human infection with HIV, HCV and dengue viruses.
Recher
Mike
M
Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland. mike.recher@usz.ch
Hunziker
Lukas
L
Ciurea
Adrian
A
Harris
Nicola
N
Lang
Karl S
KS
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D000918:Antibody Specificity; D003588:Cytopathogenic Effect, Viral; D006801:Humans; D008216:Lymphocytic Choriomeningitis / Q000276:immunology* / Q000821:virology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D051379:Mice; D008811:Mice, Inbred DBA; D009500:Neutralization Tests; D012327:RNA Virus Infections / Q000276:immunology / Q000821:virology; D012328:RNA Viruses / Q000276:immunology
D000914:Antibodies, Viral