Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu).
Structural characterization and antiviral activities of fucoidan from sporophyll of Undaria pinnatifida (Mekabu) was examined. The fucoidan was composed of fucose and galactose with an approximately ratio of 1.0:1.1. Degree of substitution of sulfate was 0.72 and its apparent molecular weight was 9,000. Methylation analyses showed that fucoidan had various sugar linkages, and revealed that the fucoidan might have complicated structure. This fucoidan showed potent antiviral activities against herpes simplex virus type 1 (HSV-1), HSV-2, and human cytomegalovirus.
Lee
Jung-Bum
JB
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan.
Hayashi
Kyoko
K
Hashimoto
Minoru
M
Nakano
Takahisa
T
Hayashi
Toshimitsu
T
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects; D004770:Enterovirus / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects; D020128:Inhibitory Concentration 50; D017955:Poliovirus / Q000187:drug effects; D011134:Polysaccharides / Q000302:isolation & purification* / Q000494:pharmacology; D044648:Undaria / Q000737:chemistry*
D000998:Antiviral Agents; D011134:Polysaccharides; C007789:fucoidan