title: System for prostate brachytherapy and biopsy in a standard 1.5 T MRI scanner.
abstract: A technique for transperineal high-dose-rate (HDR) prostate brachytherapy and needle biopsy in a standard 1.5 T MRI scanner is demonstrated. In each of eight procedures (in four patients with intermediate to high risk localized prostate cancer), four MRI-guided transperineal prostate biopsies were obtained followed by placement of 14-15 hollow transperineal catheters for HDR brachytherapy. Mean needle-placement accuracy was 2.1 mm, 95% of needle-placement errors were less than 4.0 mm, and the maximum needle-placement error was 4.4 mm. In addition to guiding the placement of biopsy needles and brachytherapy catheters, MR images were also used for brachytherapy treatment planning and optimization. Because 1.5 T MR images are directly acquired during the interventional procedure, dependence on deformable registration is reduced and online image quality is maximized.
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Susil
authors.forename: Kevin
authors.initials: K
authors.lastname: Camphausen
authors.forename: Peter
authors.initials: P
authors.lastname: Choyke
authors.forename: Elliot R
authors.initials: ER
authors.lastname: McVeigh
authors.forename: Gary S
authors.initials: GS
authors.lastname: Gustafson
authors.forename: Holly
authors.initials: H
authors.lastname: Ning
authors.forename: Robert W
authors.initials: RW
authors.lastname: Miller
authors.forename: Ergin
authors.initials: E
authors.lastname: Atalar
authors.forename: C Norman
authors.initials: CN
authors.lastname: Coleman
authors.forename: Cynthia
authors.initials: C
authors.lastname: Ménard
mesh_terms: D001707:Biopsy, Needle; D001918:Brachytherapy / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy*