title: [Effect of hydroxymethylethylpyridine succinate on the cardiac electrophysiological and hemodynamic parameters during experimental thoracotomy and acute myocardial ischemia].
abstract: Effects of the natural antioxidant hydroxymethylethylpyridine succinate (mexidol) on the electrophysiological and hemodynamic cardiac parameters were studied on narcotized mongrel cats with experimental thoracotomy and acute myocardial ischemia, as manifested by sinoatrial node automatism, conduction, effective refractory period, and excitability of myocardium. The rate of contractility (dp/dtmax) in the left ventricle and the arterial pressure level (p) were monitored using a special differentiating device. The antiarrhythmic activity of mexidol was studied by ECG. The cardioprotective effect of the drug is manifested by normalization of the electrophysiological parameters during operation (accompanied by artificial lung ventilation, thoraco- and pericardiotomy). The positive effect was also observed in operated animals with acute ischemia model. The prophylactic administration of mexidol in a dose of 7 mg/kg prevented the cardio-depressant consequences of acute ischemia and reduced the risk of ventricular arrhythmia during coronary artery occlusion.
authors.forename: A A
authors.initials: AA
authors.lastname: Kotliarov
authors.forename: L D
authors.initials: LD
authors.lastname: Smirnov
mesh_terms: D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D013908:Thoracotomy
chemical_list: D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate