title: Molecular biology. Argonaute journeys into the heart of RISC.
authors.affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA. erik@northwestern.edu
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Sontheimer
authors.forename: Richard W
authors.initials: RW
authors.lastname: Carthew
mesh_terms: D000818:Animals; D019843:Archaeal Proteins / Q000737:chemistry*; D060565:Argonaute Proteins; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D005314:Embryonic and Fetal Development; D015852:Eukaryotic Initiation Factor-2; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D010448:Peptide Initiation Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017354:Point Mutation; D017434:Protein Structure, Tertiary; D020027:Pyrococcus furiosus / Q000737:chemistry; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000378:metabolism*
chemical_list: C466422:AGO2 protein, human; D019843:Archaeal Proteins; D060565:Argonaute Proteins; D015852:Eukaryotic Initiation Factor-2; D035683:MicroRNAs; D010448:Peptide Initiation Factors; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex