Can ends justify the means? Digging deep for human fusion genes of prokaryotic origin.
Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/
Yiting
Yu
Y
School of Mechanical and Production Engineering, Nanyang Center for Supercomputing and Visualization, Nanyang Technological University, Singapore 639798.
Chaturvedi
Iti
I
Meow
Liew Kim
LK
Kangueane
Pandjassarame
P
Sakharkar
Meena Kishore
MK
D017398:Alternative Splicing; D005075:Biological Evolution; D030541:Databases, Genetic; D030562:Databases, Protein; D019143:Evolution, Molecular; D050939:Gene Fusion; D005798:Genes, Bacterial; D016678:Genome; D006801:Humans; D020407:Internet; D010802:Phylogeny; D011387:Prokaryotic Cells / Q000378:metabolism; D025941:Protein Interaction Mapping; D011993:Recombinant Fusion Proteins / Q000378:metabolism
D011993:Recombinant Fusion Proteins