Mysterious origin of plasmacytoid dendritic cell precursors.
The origin of plasmacytoid dendritic cell precursors (pDC) has been controversial. This manuscript shows that CLP and CMP both can give rise to pDCs. pDCs derived from CMP express RAG gene products and show IgHD-J rearrangement, suggesting that pDC represent a unique lineage whose gene expression program shows substantial plasticity.
Wang
Yui-Hsi
YH
Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston 77030, USA.
Liu
Yong-Jun
YJ
D002454:Cell Differentiation; D019070:Cell Lineage; D003713:Dendritic Cells / Q000502:physiology*; D015321:Gene Rearrangement; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism; D010950:Plasma Cells / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*
D007370:Interferon Type I