title: Effect of orally administered plant lectins on intestinal liquor accumulation and amylase activity in rats.
abstract: Short-term effects of orally administered plant lectins, with special reference to the Phaseolus vulgaris agglutinin (phytohaemagglutinin, PHA), were studied in growing rats. The orally administered PHA elicited a dose-dependent accumulation of liquor with elevated pH in the proximal small intestine. Although the concentration of alpha-amylase activity did not change, total alpha-amylase activity slightly, but significantly increased in the gut. When a panel of plant lectins with different carbohydrate binding specificities was tested at the dose of 100 mg/kg body weight, most of them stimulated the secretion of liquor, but the total alpha-amylase activity was increased only by PHA, ConA or WGA.
authors.affiliation: Department of Physiology, Faculty of Animal Science, University of Kaposvár, Kaposvár, Hungary. baintner@mail.atk.u-kaposvar.hu
authors.forename: K
authors.initials: K
authors.lastname: Baintner
authors.forename: P
authors.initials: P
authors.lastname: Kiss
authors.forename: S
authors.initials: S
authors.lastname: Bardocz
authors.forename: A
authors.initials: A
authors.lastname: Pusztai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002413:Cations, Divalent / Q000032:analysis; D002414:Cations, Monovalent / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D045604:Extracellular Fluid / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D037121:Plant Lectins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014361:Trypsin Inhibitors / Q000494:pharmacology; D000516:alpha-Amylases / Q000378:metabolism*
chemical_list: D002413:Cations, Divalent; D002414:Cations, Monovalent; D010835:Phytohemagglutinins; D037121:Plant Lectins; D014361:Trypsin Inhibitors; D000516:alpha-Amylases