Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp.
The structure of a new dibenzodiazepine alkaloid, diazepinomicin (1), isolated from the culture of a marine actinomycete of the genus Micromonospora was characterized using spectroscopic methods. Diazepinomicin represents a unique molecular class composed of a dibenzodiazepine core linked to a farnesyl side chain.
Charan
Romila D
RD
Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. charanr@wyeth.com
Schlingmann
Gerhard
G
Janso
Jeffrey
J
Bernan
Valerie
V
Feng
Xidong
X
Carter
Guy T
GT
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003984:Dibenzazepines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007564:Japan; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D003984:Dibenzazepines; C492422:diazepinomicin