title: [Effect of kidney-warming and astringent therapy on plasma endothelin and interleukin-2 receptor in patients with nephrotic syndrome].
abstract: OBJECTIVE
  To explore the effect and mechanism of kidney-warming and astringent therapy in treating nephrotic syndrome patients with deficiency of spleen and kidney yang and overflow of water, and to observe the change of plasma endothelin and interleukin-2 receptor after treatment.
  
  
  METHODS
  Forty-four patients were randomly divided into conventional steroid treated group (control group, 20 cases) and conventional steroid plus kidney-warming and astringent therapy treated group (treatment group, 24 cases). The levels of plasma endothelin (ET) and soluble interleukin-2 receptor (sIL-2) were observed.
  
  
  RESULTS
  Before treatment, plasma ET and sIL-2 in the patients were significantly higher than those in healthy people (P<0.01). After treatment, the ET and sIL-2 levels were obviously improved in both treated groups (P<0.05) and the improvement in the treatment group was more obvious. The difference between the two treated groups after treatment was significant (P<0.05).
  
  
  CONCLUSIONS
  Conventional treatment plus kidney-warming and astringent therapy can effectively improve the levels of plasma ET and sIL-2 in treating nephrotic syndrome patients with deficiency of spleen and kidney yang and overflow of water, and hence alleviate the damage of renal tissue.
authors.affiliation: Department of Internal Medicine, No. 211 Hospital of PLA, Haerbin, Heilongjiang Province 150080, China. lh898@up369.com
authors.forename: Hui
authors.initials: H
authors.lastname: Lu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Wang
authors.forename: Mei-Zhu
authors.initials: MZ
authors.lastname: Guo
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Wang
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood / Q000628:therapy*; D015375:Receptors, Interleukin-2 / Q000032:analysis*
chemical_list: D000305:Adrenal Cortex Hormones; D016232:Endothelins; D015375:Receptors, Interleukin-2