[Anichkov's views on the role of macrophages in atherogenesis and evolution of such views up to now].
The appearance of macrophages in arterial wall in early morphogenesis of atherosclerosis was noted by N. N. Anichkov in 1940. The macrophages originate partly from monocytic hematogenous elements, partly from subendothelial cells. The authors show that macrophages of monocytic origin play a leading role in atherogenesis-related complex cellular-molecular alterations in the zone of arterial lesions. A cascade of cellular reactions with participation of macrophages determines a chronic course of the process by type of immune inflammation reactions with autonomic regulation.
Nagornev
V A
VA
Mal'tseva
S V
SV
Vaskan'iants
A N
AN
D000818:Animals; D001161:Arteriosclerosis / Q000266:history* / Q000276:immunology / Q000473:pathology; D001808:Blood Vessels / Q000276:immunology / Q000473:pathology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000473:pathology*