Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease.
Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress marker has been reported. We measured percent content of the oxidized form of coenzyme Q10 in total coenzyme Q10 (%CoQ-10) because %CoQ-10 has been shown to be a sensitive marker of oxidative stress. A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients.
Sohmiya
Makoto
M
Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan. sohmiyam@med.gunma-u.ac.jp
Tanaka
Makoto
M
Tak
Nyou Wei
NW
Yanagisawa
Makoto
M
Tanino
Yutaka
Y
Suzuki
Yoko
Y
Okamoto
Koichi
K
Yamamoto
Yorihiro
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000201:enzymology; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003067:Coenzymes; D004563:Electrochemistry / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000097:blood* / Q000201:enzymology*; D010949:Plasma / Q000378:metabolism; D018709:Statistics, Nonparametric; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood*
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10