Detection of hepatitis A virus RNA in saliva.
Hepatitis A virus (HAV) is shed in feces but also in saliva. HAV RNA was detected in saliva in five out of six acutely infected patients with HAV viremia. Serum and saliva sequences were identical. The simplicity of obtaining material allows the recommendation of the use of saliva for investigation of outbreaks.
Mackiewicz
Vincent
V
Centre National de Référence pour les Virus à Transmission Entérique (HAV), Laboratoire de Virologie, Hôpital Paul Brousse, 94804 Villejuif, France.
Dussaix
Elisabeth
E
Le Petitcorps
Marie-France
MF
Roque-Afonso
Anne Marie
AM
D000293:Adolescent; D000328:Adult; D004196:Disease Outbreaks; D005260:Female; D006506:Hepatitis A / Q000097:blood / Q000175:diagnosis*; D030041:Hepatitis A virus / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis* / Q000097:blood; D015203:Reproducibility of Results; D012463:Saliva / Q000821:virology*
D012367:RNA, Viral