title: Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection.
abstract: The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24 h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.
authors.affiliation: Laboratório de Esquistossomose, Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil.
authors.forename: Fabio
authors.initials: F
authors.lastname: Ribeiro
authors.forename: Rômulo Teixeira de
authors.initials: RT
authors.lastname: Mello
authors.forename: Carlos Alberto Pereira
authors.initials: CA
authors.lastname: Tavares
authors.forename: John Robert
authors.initials: JR
authors.lastname: Kusel
authors.forename: Paulo Marcos Zech
authors.initials: PM
authors.lastname: Coelho
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000276:immunology / Q000494:pharmacology*; D000909:Antibodies, Helminth / Q000187:drug effects / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000187:drug effects / Q000276:immunology; D051379:Mice; D011223:Praziquantel / Q000276:immunology / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
chemical_list: D000871:Anthelmintics; D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D011223:Praziquantel