title: C-reactive protein concentrations are related to insulin resistance and metabolic syndrome as defined by the ATP III report.
abstract: BACKGROUND
  C-reactive protein (CRP), very sensitive acute phase reactant, is an important marker of coronary artery disease. However, the relationship between insulin resistance and CRP has not been thoroughly studied. We observed the association between CRP, insulin resistance and metabolic syndrome as defined by the ATP III report, and thus identified the role of CRP in the relation to insulin resistance.
  
  
  METHODS
  Seven hundred and sixty-seven subjects (436 men, 331 women) who underwent a medical check-up at health promotion center in a University Hospital during March 2002, aged 20-84 years, were included in this study. The components of metabolic syndrome as defined by the ATP III report and high sensitivity CRP levels were analyzed, and Homeostasis model assessment index (HOMA) and quantitative insulin sensitivity check index (QUICKI) were calculated.
  
  
  RESULTS
  The mean concentrations of CRP in subjects according to the presence of 0, 1, 2, 3, 4, or 5 components of metabolic syndrome as defined by ATP III were 0.64, 0.95, 1.14, 1.19, 2.40, and 2.53 mg/l, respectively. The mean concentrations of CRP were significantly higher in subjects with a high insulin resistance (higher HOMA index and lower QUICKI) than in those with a low insulin resistance. Significant positive correlations were identified between CRP and BMI, waist circumference, triglyceride, blood pressure, glucose and HOMA index. A significant negative correlation was found between CRP and HDL cholesterol or QUICKI.
  
  
  CONCLUSIONS
  These results suggest that metabolic syndrome and insulin resistance are associated with systemic inflammatory response, which plays an important pathogenic role in atherosclerosis.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, #108 Pyung-Dong, Jongro-Ku, Seoul 110-746, South Korea. drlwy@samsung.co.kr
authors.forename: Won-Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Jeong-Sik
authors.initials: JS
authors.lastname: Park
authors.forename: Sang-Young
authors.initials: SY
authors.lastname: Noh
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
authors.forename: Bum-Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Kang
authors.forename: Sun-Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Man-Ho
authors.initials: MH
authors.lastname: Lee
authors.forename: Jung-Ro
authors.initials: JR
authors.lastname: Park
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged
chemical_list: D002097:C-Reactive Protein