title: Diastereoselective dihydroxylation and regioselective deoxygenation of dihydropyranones: a novel protocol for the stereoselective synthesis of C1-C8 and C15-C21 subunits of (+)-discodermolide.
abstract: Diastereoselective dihydroxylation of dihydropyranones and subsequent regioselective alpha-deoxygenation provides 1,3-trans-beta-hydroxy-delta-lactones stereoselectively. This protocol has been applied for the synthesis of C(1)-C(8) and C(15)-C(21) subunits of (+)-discodermolide.
authors.affiliation: Herbert C. Brown Center for Borane Research, 560 Oval Drive, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, USA. chandran@purdue.edu
authors.forename: P Veeraraghavan
authors.initials: PV
authors.lastname: Ramachandran
authors.forename: Bodhuri
authors.initials: B
authors.lastname: Prabhudas
authors.forename: J Subash
authors.initials: JS
authors.lastname: Chandra
authors.forename: M Venkat Ram
authors.initials: MV
authors.lastname: Reddy