title: Vestibular schwannoma growth rates in neurofibromatosis type 2 natural history consortium subjects.
abstract: OBJECTIVE
  To determine the amount of growth in vestibular schwannomas in Neurofibromatosis type 2 (NF2) patients from diagnosis through short-term (up to 2 yr) and long-term (up to 4 yr) follow-up.
  
  
  METHODS
  Retrospective magnetic resonance imaging (MRI) films were obtained on subjects enrolled in the NF2 Natural History study and examined for changes in vestibular schwannoma size over time.
  
  
  METHODS
  Data were collected from nine foreign and domestic NF2 centers, including hospital-based, academic, and tertiary care centers.
  
  
  METHODS
  NF2 patients with MRI data and at least one follow-up examination within 9 months to 2 years of diagnosis were included; n=56 patients with 84 lesions for evaluation of growth.
  
  
  METHODS
  Routine, clinically obtained, magnetic resonance images were digitized and measured using image management software. Short-term follow-up was defined as up to 2 years (n=84 lesions), and long-term follow-up was defined as 3 to 4 years (n=29 lesions).
  
  
  METHODS
  Vestibular schwannoma size was assessed using anterior-posterior, medial-lateral, and greatest diameter linear measurements.
  
  
  RESULTS
  Vestibular schwannomas increased in size (at least 5 mm) in 8% of the vestibular schwannomas across short-term follow-up. At long-term follow-up, 13% of the tumors had increased in size. On average, schwannomas increased in greatest diameter 1.3 mm per year across short-term follow-up.
  
  
  CONCLUSIONS
  Slightly greater than 1 in 10 diagnosed NF2-related vestibular schwannomas increased in size by at least 5 mm by 4 years of follow-up, if still untreated at that time.
authors.affiliation: House Ear Institute, Los Angeles, California 90057, USA. wslattery@hei.org
authors.forename: William H
authors.initials: WH
authors.lastname: Slattery
authors.forename: Laurel M
authors.initials: LM
authors.lastname: Fisher
authors.forename: Zarina
authors.initials: Z
authors.lastname: Iqbal
authors.forename: Mark
authors.initials: M
authors.lastname: Oppenhiemer
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D016518:Neurofibromatosis 2 / Q000150:complications / Q000473:pathology*; D009464:Neuroma, Acoustic / Q000150:complications / Q000473:pathology*; D012189:Retrospective Studies