Risk factors for the deterioration of glucose metabolism in polycystic ovary syndrome.
Women with polycystic ovary syndrome (PCOS) have a high risk of abnormal glucose metabolism, which deteriorates gradually over time. This study was designed to assess contributing factors to the rate of deterioration of glucose metabolism over the 4- to 7-year follow-up period. The study group included 67 PCOS women who had normal glucose tolerance in the initial test in 1990-1992. There was a significant increase in both fasting and 2-h glucose concentrations, and body weight, over the follow-up period. The initial obesity, expressed as waist:hip ratio and BMI, was significantly related to the increase of glucose concentrations, while weight gain was not a significant factor. The overweight/obese PCOS women have a faster deterioration of glucose metabolism over the follow-up period than the non-obese ones. Moderate weight gain has no significant detrimental effect on the rate of deterioration of glucose metabolism.
Wang
Jim X
JX
Repromed, Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, The Queen Elizabeth Hospital, Woodville, Australia 5011. jim.wang@adelaide.edu.au
Norman
Robert J
RJ
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001824:Body Constitution; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D009765:Obesity / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology*; D012307:Risk Factors; D013997:Time Factors; D049629:Waist-Hip Ratio
D001786:Blood Glucose