title: [Studies on mother-to-infant transmission of hepatitis C virus (HCV) and hepatitis G virus (HGV) co-infection].
abstract: OBJECTIVE
  To explore mother-to-infant transmission of hepatitis C virus (HCV) and hepatitis G virus (HGV) co-infection and the influence factors.
  
  
  METHODS
  Antihepatitis C virus (anti-HCV) and anti-hepatitis G virus (anti-HGV) antibodies were detected by third generation enzyme linked immunosorbent assay (ELISA). HCV RNA and HGV RNA were detected by fluorogenic quantitative-PCR (FQ-PCR).
  
  
  RESULTS
  Totally 4506 common pregnant women were tested positive of serum anti-HCV. In these women, 878 were detected of serum anti-HGV, and 10 of them were found with both HCV RNA and HGV RNA positivities. In their 11 infants, two were positive for HCV RNA, and two were positive for HGV RNA. In these 4 infected infants, three were delivered by birth canal, one was delivered by cesarean section. All four were fed by breast-feeding. Three mother's ALTs were abnormally high before delivery.
  
  
  CONCLUSIONS
  Hepatitis C and G virus co-infection does not increase the rate of mother-to-infant transmission. Birth canal delivery, breast-feeding and high alanine aminotransferase before delivery are high risk factors for mother-to-infant transmission of HCV and HGV co-infection.
authors.affiliation: Department of Infection, Second Affiliated Hospital of Medical College of Shantou University, Shantou 515000, China.
authors.forename: Zhan-Cheng
authors.initials: ZC
authors.lastname: Yao
authors.forename: Ming-Chun
authors.initials: MC
authors.lastname: Chen
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Chen
authors.forename: Ren-Hua
authors.initials: RH
authors.lastname: Zhang
authors.forename: Jie-Wen
authors.initials: JW
authors.lastname: Qiu
authors.forename: Hong-Qiu
authors.initials: HQ
authors.lastname: Cheng
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Yang
mesh_terms: D000328:Adult; D005260:Female; D018178:Flaviviridae Infections / Q000635:transmission*; D029407:GB virus C; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000635:transmission*; D006525:Hepatitis, Viral, Human / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D015163:Superinfection / Q000635:transmission
chemical_list: D006508:Hepatitis Antibodies