title: Mechanical and biological properties of hydroxyapatite reinforced with 40 vol. % titanium particles for use as hard tissue replacement.
abstract: Hydroxyapatite (HA)-based composite reinforced with 40 vol. % Ti particles was fabricated by the optimal technical condition of hot pressing technique. The mechanical and biological properties of the composite were studied by mechanical and in vivo methods. The experimental results show that HA and Ti phases are the predominant phases of the composite with partially decomposition of HA phase into alpha-Ca3(PO4)2 and Ca4O(PO4)2. Comparing with HA-20 vol. % Ti composite manufactured under the same conditions, HA-40 vol. % Ti composite with similar elastic modulus (79.3 GPa) and Vicker's hardness (2.94GPa) has a higher bending strength (92.1 MPa). Moreover, fracture toughness of HA-40 vol. % Ti composite with crack bridging as the chief toughening mechanisms can reach 2.692 MPa m(-1) , which can meet the basic toughness demand of the replaced hard tissues for heavy load-bearing applications. Work of fracture of HA-40 vol. % Ti composite is 91.2J m2, which is 22.9 times that of pure HA ceramic and even 2.4 times that of Al2O3 bioceramic. The results of in vivo studies show HA-40 vol. % Ti composite has excellent biocompatibility and could integrate with bone. In the early stage after the implantation of the samples, the osteointegration ability of the composite is better than that of pure titanium.
authors.affiliation: Department of Mechanical Engineering, Southeast University, Nanjing 210018, China. clchu@seu.edu.cn
authors.forename: Chenglin
authors.initials: C
authors.lastname: Chu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xue
authors.forename: Jingchuan
authors.initials: J
authors.lastname: Zhu
authors.forename: Zhongda
authors.initials: Z
authors.lastname: Yin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001846:Bone Development; D018786:Bone Substitutes / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004548:Elasticity; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology*; D006244:Hardness; D008420:Manufactured Materials / Q000032:analysis; D008422:Materials Testing; D008968:Molecular Conformation; D016348:Osseointegration; D019736:Prostheses and Implants / Q000009:adverse effects*; D011817:Rabbits; D012886:Skull / Q000473:pathology* / Q000601:surgery; D013499:Surface Properties; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite; D014025:Titanium