title: Synthesis of dimeric acridine derived antivirals.
abstract: A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by >8 logarithmic decades.
authors.affiliation: Institut f. Organ. Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de
authors.forename: René
authors.initials: R
authors.lastname: Csuk
authors.forename: Alexander
authors.initials: A
authors.lastname: Barthel
authors.forename: Torsten
authors.initials: T
authors.lastname: Brezesinski
authors.forename: Christian
authors.initials: C
authors.lastname: Raschke
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D019281:Dimerization; D017909:Levivirus / Q000187:drug effects
chemical_list: D000166:Acridines; D000998:Antiviral Agents; D001205:Ascorbic Acid