Congenital cardiac disease as a core feature of cranio-osteoarthropathy.
Cranio-osteoarthropathy is a rare condition. Classically, signs are identifiable in infancy with clubbing of fingers, and delayed closure of the clinically enlarged cranial sutures, followed by periosteal new bone formation on X-rays of the long bones. Ultimately, joint swelling and stiffness follow, typically involving the large joints. We report two unrelated patients with features of cranio-osteoarthropathy, both of whom also had a history of congenital heart disease. Moreover, the cases reported here, manifesting significant differences in radiological features, emphasize the variability of radiological findings which can attend this condition.
O'Connell
Susan
S
Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland Clinical Genetic Service, City Hospital, Nottingham, UK Great Ormond Street Hospital for Children, London, UK.
Suri
Mohnish
M
Duff
Desmond
D
Kelleher
Jeremiah
J
Hall
Christine M
CM
Reardon
William
W
D000842:Ankle / Q000002:abnormalities; D001842:Bone and Bones / Q000002:abnormalities*; D002675:Child, Preschool; D005260:Female; D005385:Fingers / Q000002:abnormalities / Q000000981:diagnostic imaging; D006331:Heart Diseases / Q000503:physiopathology*; D006801:Humans; D007717:Knee / Q000002:abnormalities; D007866:Leg / Q000002:abnormalities / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging; D013577:Syndrome