title: K103N mutation in antiretroviral therapy-naive African patients infected with HIV type 1.
abstract: Most of the information about genetic sequencing and drug susceptibility of human immunodeficiency virus type 1 (HIV-1) is derived from the study of HIV-1 subtype B. Worldwide, most people infected with HIV-1 are infected with non-subtype B viruses and live in developing countries. We report 3 cases of antiretroviral-naive African immigrants infected with HIV-1 strains possessing the K103N mutation in the reverse transcriptase gene, which confers high-level resistance to all nonnucleoside reverse transcriptase inhibitors.
authors.affiliation: Department of Infectious Diseases, University of Minnesota/Hennepin County Medical Center, Minneapolis, Minnesota 55455, USA. BosolaA@aol.com
authors.forename: Omobosola
authors.initials: O
authors.lastname: Akinsete
authors.forename: Diane
authors.initials: D
authors.lastname: Hirigoyen
authors.forename: Charles
authors.initials: C
authors.lastname: Cartwright
authors.forename: Ron
authors.initials: R
authors.lastname: Schut
authors.forename: Rami
authors.initials: R
authors.lastname: Kantor
authors.forename: Keith
authors.initials: K
authors.lastname: Henry
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D023241:Antiretroviral Therapy, Highly Active / Q000639:trends; D001216:Asparagine / Q000235:genetics* / Q000502:physiology; D024882:Drug Resistance, Viral / Q000235:genetics* / Q000502:physiology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008239:Lysine / Q000235:genetics* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense / Q000235:genetics*; D012194:RNA-Directed DNA Polymerase / Q000235:genetics / Q000502:physiology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins; D001216:Asparagine; D012194:RNA-Directed DNA Polymerase; D008239:Lysine