Increase in methicillin-resistant Staphylococcus aureus acquisition rate and change in pathogen pattern associated with an outbreak of severe acute respiratory syndrome.
BACKGROUND
An outbreak of severe acute respiratory syndrome (SARS) occurred in our 22-bed intensive care unit (ICU; Prince of Wales Hospital, Hong Kong, HKSAR, China) from 12 March to 31 May 2003, when only patients with SARS were admitted. This period was characterized by the upgrading of infection control precautions, which included the wearing of gloves and gowns all the time, an extensive use of steroids, and a change in antibiotic prescribing practices. The pattern of endemic pathogenic organisms, the rates of acquisition of methicillin-resistant Staphylococcus aureus (MRSA), and the rates of ventilator-associated pneumonia (VAP) were compared with those of the pre-SARS and post-SARS periods.


METHODS
Data on pathogenic isolates were obtained from the microbiology department (Prince of Wales Hospital). Data on MRSA acquisition and VAP rates were collected prospectively. MRSA screening was performed for all ICU patients. A case of MRSA carriage was defined as an instance in which MRSA was recovered from any site in a patient, and cases were classified as imported or ICU-acquired if the first MRSA isolate was recovered within 72 h of ICU admission or after 72 h in the ICU, respectively.


RESULTS
During the SARS period in the ICU, there was an increase in the rate of isolation of MRSA and Stenotrophomonas and Candida species but a disappearance of Pseudomonas and Klebsiella species. The MRSA acquisition rate was also increased: it was 3.53% (3.53 cases per 100 admissions) during the pre-SARS period, 25.30% during the SARS period, and 2.21% during the post-SARS period (P<.001). The VAP rate was high, at 36.5 episodes per 1000 ventilator-days, and 47% of episodes were caused by MRSA.


CONCLUSIONS
A SARS outbreak in the ICU led to changes in the pathogen pattern and the MRSA acquisition rate. The data suggest that MRSA cross-transmission may be increased if gloves and gowns are worn all the time.
Yap
Florence H Y
FH
Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China. yhyyap@cuhk.edu.hk
Gomersall
Charles D
CD
Fung
Kitty S C
KS
Ho
Pak-Leung
PL
Ho
Oi-Man
OM
Lam
Phillip K N
PK
Lam
Doris T C
DT
Lyon
Donald J
DJ
Joynt
Gavin M
GM
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000627:therapeutic use; D003428:Cross Infection; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D004784:Environmental Monitoring / Q000379:methods; D062665:Epidemiological Monitoring; D006723:Hong Kong; D006801:Humans; D017053:Infection Control; D007362:Intensive Care Units; D008712:Methicillin / Q000378:metabolism / Q000627:therapeutic use; D016106:Methicillin Resistance; D018410:Pneumonia, Bacterial / Q000453:epidemiology; D012121:Respiration, Artificial / Q000009:adverse effects; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents; D008712:Methicillin