title: Evaluation of the effects of Helicobacter pylori eradication therapy on gastric antral epithelial hyperproliferation: a prospective six-month follow-up study.
abstract: OBJECTIVE
  H. pylori-induced hyperproliferation of the gastric epithelium may have a critical role in gastric carcinogenesis. H. pylori-related hyperproliferation and reversibility of hyperproliferation after eradication therapy is still controversial. Therefore, we have evaluated the effects of H. pylori and its eradication on gastric antral epithelial proliferation.
  
  
  METHODS
  A total of 32 H. pylori-positive and 22 H. pylori-negative subjects were enrolled into the study. Triple eradication therapy was given to the H. pylori-positive group. Upper endoscopy was repeated one month after the therapy and six months later, antral biopsy specimens were taken in each endoscopy. Biopsy specimens from H. pylori-negative subject were taken at the beginning of the study and sixth months later also.
  
  
  RESULTS
  Proliferative index was 40.2% in H. pylori-positive state; it regressed to 27.6% after eradication and six months later the proliferative index was 30.7%. H. pylori-negative group's proliferative index was 25.5% initially and six months later it was 25.6%. The difference between the H. pylori-positive and -negative group was statistically significant (p<0.0001). The difference between H. pylori-positive group's values at the beginning of the study and one month after the eradication was significant (p<0.0001). In addition, the difference between H. pylori-positive group's initial values and those six months after eradication was also significant (p<0.0001).
  
  
  CONCLUSIONS
  H. pylori increased the gastric epithelial proliferation and after the eradication therapy proliferative index decreased to control values. H. pylori and the related factors inducing gastric antral hyperproliferation may have an important role in H. pylori-related gastric malignancies.
authors.affiliation: Department of Medical Oncology, Uludag University Medical School, Bursa, Turkey. mdemiray@uludag.edu.tr
authors.forename: Mutlu
authors.initials: M
authors.lastname: Demiray
authors.forename: Macit
authors.initials: M
authors.lastname: Gulten
authors.forename: Osman
authors.initials: O
authors.lastname: Manavoglu
authors.forename: Turkkan
authors.initials: T
authors.lastname: Evrensel
authors.forename: Engin
authors.initials: E
authors.lastname: Ulukaya
authors.forename: Omer
authors.initials: O
authors.lastname: Yerci
authors.forename: Ozkan
authors.initials: O
authors.lastname: Kanat
authors.forename: Ender
authors.initials: E
authors.lastname: Kurt
authors.forename: Murat
authors.initials: M
authors.lastname: Arslan
authors.forename: Guzin
authors.initials: G
authors.lastname: Gonullu
authors.forename: Hulya
authors.initials: H
authors.lastname: Demiray
authors.forename: Tuna
authors.initials: T
authors.lastname: Gulten
authors.forename: Faruk
authors.initials: F
authors.lastname: Memik
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001706:Biopsy; D002455:Cell Division / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000473:pathology; D017291:Clarithromycin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy* / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011706:Pyloric Antrum / Q000187:drug effects / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology / Q000517:prevention & control*; D014774:Virulence / Q000187:drug effects
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D064747:Lansoprazole; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole