Immunogenicity of an inactivated oil-emulsion canine distemper vaccine in African wild dogs.
The immunogenicity of an inactivated oil-emulsion vaccine against canine distemper virus was evaluated in nine captive African wild dogs (Lycaon pictus). Antibody levels were determined by neutralization test in Vero cells. No significant local or systemic adverse reactions were observed in the animals. Virus neutralizing antibody levels >1:20 were detected, especially in animals that were vaccinated twice. The use of oil adjuvants is suggested as a good way to enhance the immune response to inactivated canine distemper vaccine.
Cirone
Francesco
F
Department of Animal Health and Well-being, Faculty of Veterinary Medicine of Bari, Valenzano, Italy. f.cirone@veterinaria.uniba.it
Elia
Gabriella
G
Campolo
Marco
M
Friedrich
Klaus
K
Martella
Vito
V
Pratelli
Annamaria
A
Buonavoglia
Canio
C
D000818:Animals; D000835:Animals, Wild; D000914:Antibodies, Viral / Q000097:blood*; D046028:Canidae; D004216:Distemper / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology*; D004285:Dogs; D004655:Emulsions; D005260:Female; D008297:Male; D009500:Neutralization Tests / Q000662:veterinary; D016896:Treatment Outcome; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D004655:Emulsions; D015164:Vaccines, Inactivated; D014765:Viral Vaccines