System for prostate brachytherapy and biopsy in a standard 1.5 T MRI scanner.
A technique for transperineal high-dose-rate (HDR) prostate brachytherapy and needle biopsy in a standard 1.5 T MRI scanner is demonstrated. In each of eight procedures (in four patients with intermediate to high risk localized prostate cancer), four MRI-guided transperineal prostate biopsies were obtained followed by placement of 14-15 hollow transperineal catheters for HDR brachytherapy. Mean needle-placement accuracy was 2.1 mm, 95% of needle-placement errors were less than 4.0 mm, and the maximum needle-placement error was 4.4 mm. In addition to guiding the placement of biopsy needles and brachytherapy catheters, MR images were also used for brachytherapy treatment planning and optimization. Because 1.5 T MR images are directly acquired during the interventional procedure, dependence on deformable registration is reduced and online image quality is maximized.
Susil
Robert C
RC
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Camphausen
Kevin
K
Choyke
Peter
P
McVeigh
Elliot R
ER
Gustafson
Gary S
GS
Ning
Holly
H
Miller
Robert W
RW
Atalar
Ergin
E
Coleman
C Norman
CN
Ménard
Cynthia
C
D001707:Biopsy, Needle; D001918:Brachytherapy / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy*