title: Briarane diterpenes from two species of octocorals, Ellisella sp. and Pteroeides sp.
abstract: Eight new briarane diterpenes (1-4, 7-10) have been isolated from two species of octocorals and the structures elucidated by spectroscopic analysis. Two diterpenes (2, 3) from the gorgonian Ellisella sp. inhibited cytokinesis, causing multinuclei formation on NBT-II cells, while a known briarane (12) from the sea pen Pteroeides sp. showed reversal of multidrug resistance.
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Tanaka
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Masahito
authors.initials: M
authors.lastname: Otsuka
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
authors.forename: Toshio
authors.initials: T
authors.lastname: Ichiba
authors.forename: Gerard
authors.initials: G
authors.lastname: Marriott
authors.forename: Rachmaniar
authors.initials: R
authors.lastname: Rachmat
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Higa
mesh_terms: D000818:Animals; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007564:Japan; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D004224:Diterpenes