title: A resource to acquire and summarize pharmacogenetics knowledge in the literature.
abstract: To determine how genetic variations contribute the variations in drug response, we need to know the genes that are related to drugs of interest. But there are no publicly available data-bases of known gene-drug relationships, and it is time-consuming to search the literature for this information. We have developed a resource to support the storage, summarization, and dissemination of key gene-drug interactions of relevance to pharmacogenetics. Extracting all gene-drug relationships from the literature is a daunting task, so we distributed a tool to acquire this knowledge from the scientific community. We also developed a categorization scheme to classify gene-drug relationships according to the type of pharmacogenetic evidence that supports them. Our resource (http://www.pharmgkb.org/home/project-community.jsp) can be queried by gene or drug, and it summarizes gene-drug relationships, categories of evidence, and supporting literature. This resource is growing, containing entries for 138 genes and 215 drugs of pharmacogenetics significance, and is a core component of PharmGKB, a pharmacogenetics knowledge base (http://www.pharmgkb.org).
authors.affiliation: Department of Genetics, Stanford University, Stanford, CA 94305-5210, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Rubin
authors.forename: Michelle
authors.initials: M
authors.lastname: Carrillo
authors.forename: Mark
authors.initials: M
authors.lastname: Woon
authors.forename: John
authors.initials: J
authors.lastname: Conroy
authors.forename: Teri E
authors.initials: TE
authors.lastname: Klein
authors.forename: Russ B
authors.initials: RB
authors.lastname: Altman
mesh_terms: D016206:Databases, Bibliographic; D005796:Genes; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D004364:Pharmaceutical Preparations; D010597:Pharmacogenetics; D011381:Programming Languages
chemical_list: D004364:Pharmaceutical Preparations