HIV disease and an atherosclerotic ascending aortic aneurysm.
Cardiovascular dysfunction appears to be an important complication of human immunodeficiency virus (HIV) infection and is being reported with greater frequency. There have been recent reports in the literature of HIV patients who suffer from vascular lesions such as large artery vasculopathy secondary to vasculitis, as well as accelerated atherosclerosis of the coronary arteries. The latter has been linked to patients on protease inhibitors that are used as part of a highly active antiretroviral therapy (HAART) regimen and have also been implicated in a lipodystrophy syndrome. We report a rare case of an HIV-infected patient on HAART who presented with a large ascending aortic aneurysm associated with symptomatic severe aortic regurgitation. A noteworthy finding on pathological analysis of the aorta was an etiology of accelerated atherosclerosis rather than the more expected vasculitis.
Mirza
Humair
H
State University of New York at Stony Brook, Stony Brook, NY, USA.
Patel
Parag
P
Suresh
Krishnamurthy
K
Krukenkamp
Irvin
I
Lawson
William E
WE
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000209:etiology; D001022:Aortic Valve Insufficiency / Q000175:diagnosis; D001025:Aortitis / Q000175:diagnosis / Q000209:etiology; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003937:Diagnosis, Differential; D017548:Echocardiography, Transesophageal; D015658:HIV Infections / Q000188:drug therapy*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis; D008297:Male; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis