title: [Portal venous and enteric drainage in simultaneous pancreas kidney transplantation].
abstract: OBJECTIVE
  To summarize the initial experience of simultaneous pancreas kidney transplantation (SPK) with portal venous and enteric drainage.
  
  
  METHODS
  Between Jane 2001 and Jane 2003, SPK were performed in 5 patients. Systemic venous-enteric drainage (SED) was used in the first 2 patients and portal venous-enteric drainage (PED) in the last 3 cases. All patient were immunosuppressed with quadruple therapy, which included anti-CD25 mAb (Zenapax/Simulect) induction therapy, FK506, mycophenolate mofetil (MMF), and prednisone baseline therapy. The complications were analyzed.
  
  
  RESULTS
  Serum glucose and renal function of the 5 cases were normal and no further insulin was needed within 7 days post-operation. No technique complications such as duodenal fistula and thrombosis were observed, One episode of acute rejection of kidney allograft occurred in one patient with SED, and resolved with a bolus corticosteroids. One case with SED and one with PED were died of sepsis and FK506 toxicity 4 weeks after transplantation. The death occurred with functioning pancreas graft. No latter complications were observed in the 3 survived patients with excellent graft functions.
  
  
  CONCLUSIONS
  Both methods of SED and PED can be performed successfully and with no latter complications. But with its potential physiologic and immunologic advantages, PED might be a standard procedure for SPK.
authors.affiliation: Department of General Surgery, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
authors.forename: Zhi-Hai
authors.initials: ZH
authors.lastname: Peng
authors.forename: Jun-Ming
authors.initials: JM
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Fan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xia
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Chen
authors.forename: Zhe-Cheng
authors.initials: ZC
authors.lastname: Zhu
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Zheng-Jun
authors.initials: ZJ
authors.lastname: Qiu
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Dai
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery*; D004322:Drainage / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007422:Intestines / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D016035:Pancreas Transplantation / Q000379:methods*; D011169:Portal Vein / Q000601:surgery; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014511:Uremia / Q000601:surgery