Adiponectin is related to CD146, a novel marker of endothelial cell activation/injury in chronic renal failure and peritoneally dialyzed patients.
Adiponectin has antiatherogenic properties and attenuates endothelial inflammatory responses. CD146 is a novel cell adhesion molecule localized at the endothelial junction. In renal failure, endothelial dysfunction and atherosclerosis are almost universal. We studied possible correlations between adiponectin, CD146, and other markers of endothelial cell injury in patients with chronic renal failure (CRF) on conservative treatment and patients with and without diabetic nephropathy maintained on chronic ambulatory peritoneal dialysis (CAPD). We assessed adiponectin, tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor (PAI-1), thrombin-activatable fibrinolysis inhibitor, and endothelial function/injury markers: von Willebrand factor, thrombomodulin, vascular cell adhesion molecule (VCAM), intercellular adhesion molecule, and CD146. Adiponectin was elevated in patients with CRF and on CAPD. It correlated significantly, with PAI-1, thrombin-activatable fibrinolysis inhibitor, intercellular adhesion molecule, VCAM, and CD146 in nondiabetics on CAPD. In diabetics, CAPD adiponectin correlated positively with C146 and VCAM and negatively with PAI and TFPI. In multivariate regression analysis, only CD146 remained a positive predictor of adiponectin in all CAPD patients. In CRF, adiponectin correlated with CD146. In healthy volunteers, adiponectin correlated with TFPI and CD146. Elevated adiponectin related to CD146 may be the expression of a counterregulatory response aimed at mitigating the consequences in endothelial damage and increased cardiovascular risk in renal failure.
Malyszko
Jolanta
J
Department of Nephrology and Transplantology, Medical University, 15-540 Bialystok, Zurawia 14, Poland. jolmal@poczta.onet.pl
Malyszko
Jacek S
JS
Brzosko
Szymon
S
Wolczynski
Slawomir
S
Mysliwiec
Michal
M
D052242:Adiponectin; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D015415:Biomarkers; D051929:CD146 Antigen; D002318:Cardiovascular Diseases / Q000097:blood; D042783:Endothelial Cells / Q000473:pathology / Q000502:physiology*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019006:Neural Cell Adhesion Molecules / Q000097:blood*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011506:Proteins / Q000032:analysis*; D018180:Thrombomodulin / Q000032:analysis
D052242:Adiponectin; D015703:Antigens, CD; D015415:Biomarkers; D051929:CD146 Antigen; D036341:Intercellular Signaling Peptides and Proteins; C497902:MCAM protein, human; D019006:Neural Cell Adhesion Molecules; D017395:Plasminogen Activator Inhibitor 1; D011506:Proteins; D018180:Thrombomodulin