Screening of oxazepine indole enantiomers by means of high performance liquid chromatography with imprinted polymer stationary phase.
Chromatographic enantiomer separations of different oxazepine indole derivatives were performed using a molecularly imprinted polymer. A 5aR,12R,13S-trans-6,6-dimethyl-12,13-dihydro-6H-5a, 1 3-methanoindolo[2,1-b][1,3]naphthoxazepine-12-carboxamide enantiomerderivative was used as a template and the resultant polymer has shown enantiomer recognition for series of template related compounds. The mechanistic description of the chiral discrimination process is scrutinised, comparing the discrimination between the different conformations and substituents of the oxazepine indoles.
Machtejevas
Egidijus
E
Dept. of Chemistry, Vytautas Magnus University, Vileikos 8, LT-44404 Kaunas, Lithuania.
Sellergren
Börje
B
Martynaitis
Vytas
V
Owens
Paul K
PK
Maruska
Audrius
A
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007202:Indicators and Reagents; D008958:Models, Molecular; D010077:Oxazepines / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism
D007202:Indicators and Reagents; D010077:Oxazepines