title: Enhancement of vaccine-specific cellular immunity in infants by passively acquired maternal antibody.
abstract: The known protective effects of passively acquired maternal antibody on the resistance of newborns to infections have prompted widespread interest in maternal vaccination. However, a range of animal model and human studies indicate potential inhibitory effects of maternal antibody on vaccine-specific humoral responses in infants. In the present study we have examined the relationship between maternally acquired TT-specific IgG present before DTaP vaccination and subsequent TT-specific T-cell memory responses at 12 and 18 months, in a cohort of 118 infants. We demonstrate a strong positive association between TT-specific cellular immunity as evidenced by increased IL-4, IL-5 and IL-13 responses, and maternal TT-specific IgG.
authors.affiliation: The University of Western Australia, West Perth, WA 6872, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Rowe
authors.forename: J T
authors.initials: JT
authors.lastname: Poolman
authors.forename: C
authors.initials: C
authors.lastname: Macaubas
authors.forename: P D
authors.initials: PD
authors.lastname: Sly
authors.forename: R
authors.initials: R
authors.lastname: Loh
authors.forename: P G
authors.initials: PG
authors.lastname: Holt
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D015331:Cohort Studies; D016207:Cytokines / Q000096:biosynthesis*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D007156:Immunologic Memory; D007223:Infant; D007371:Interferon-gamma / Q000096:biosynthesis; D018793:Interleukin-13 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D016207:Cytokines; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D007074:Immunoglobulin G; D018793:Interleukin-13; D015848:Interleukin-5; D013745:Tetanus Toxoid; D015847:Interleukin-4; D007371:Interferon-gamma