title: Mysterious origin of plasmacytoid dendritic cell precursors.
abstract: The origin of plasmacytoid dendritic cell precursors (pDC) has been controversial. This manuscript shows that CLP and CMP both can give rise to pDCs. pDCs derived from CMP express RAG gene products and show IgHD-J rearrangement, suggesting that pDC represent a unique lineage whose gene expression program shows substantial plasticity.
authors.affiliation: Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston 77030, USA.
authors.forename: Yui-Hsi
authors.initials: YH
authors.lastname: Wang
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage; D003713:Dendritic Cells / Q000502:physiology*; D015321:Gene Rearrangement; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism; D010950:Plasma Cells / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*
chemical_list: D007370:Interferon Type I