title: Tumor metastasis: a new twist on epithelial-mesenchymal transitions.
abstract: Epithelial-mesenchymal transitions are essential for normal embryonic development and for progression of non-invasive tumor cells into malignant, metastatic carcinomas. Twist, an important regulator of morphogenesis in the embryo, has recently been implicated in the onset of invasive behavior during tumor progression.
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center, Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Vernon
authors.forename: Carole
authors.initials: C
authors.lastname: LaBonne
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism; D004848:Epithelium / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D008648:Mesoderm / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009687:Nuclear Proteins / Q000378:metabolism* / Q000502:physiology; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology; D051879:Twist-Related Protein 1
chemical_list: D015820:Cadherins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D051879:Twist-Related Protein 1