title: Enoxaparin can be used safely in patients with severe thrombocytopenia due to intensive chemotherapy regimens.
abstract: Treatment with intensive chemotherapy regimens is frequently complicated by severe thrombocytopenia. During the period of severe thrombocytopenia, anticoagulant treatment is not uncommonly indicated for thromboembolic events or thromboprophylaxis in these patients. We report 10 hematological patients treated with intensive chemotherapy protocols that were anticoagulated with enoxaparin for catheter related central venous thrombosis and thromboprophylaxis. During the period of severe thrombocytopenia the dosages of enoxaparin were reduced and no major bleeding occurred. Based on our experience we suggest that reduced dosages of low molecular weight heparins may be used relatively safely during transient severe thrombocytopenia.
authors.affiliation: Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. herishanu@yahoo.com
authors.forename: Yair
authors.initials: Y
authors.lastname: Herishanu
authors.forename: Mudi
authors.initials: M
authors.lastname: Misgav
authors.forename: Ilya
authors.initials: I
authors.lastname: Kirgner
authors.forename: Ofira
authors.initials: O
authors.lastname: Ben-Tal
authors.forename: Amiram
authors.initials: A
authors.lastname: Eldor
authors.forename: Ella
authors.initials: E
authors.lastname: Naparstek
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002405:Catheterization, Central Venous / Q000009:adverse effects; D003131:Combined Modality Therapy; D017984:Enoxaparin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D019337:Hematologic Neoplasms / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D013921:Thrombocytopenia / Q000139:chemically induced*; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin