Discovery of new chemical leads for prostaglandin D2 receptor antagonists.
A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure-activity relationship data are also presented.
Torisu
Kazuhiko
K
Minase Research Institute, Ono Pharmaceutical Co., Ltd, Shimamoto, Mishima, Osaka 618-8585, Japan. torisu@ono.co.jp
Kobayashi
Kaoru
K
Iwahashi
Maki
M
Egashira
Hiromu
H
Nakai
Yoshihiko
Y
Okada
Yutaka
Y
Nanbu
Fumio
F
Ohuchida
Shuichi
S
Nakai
Hisao
H
Toda
Masaaki
M
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D051379:Mice; D011448:Prostaglandin Antagonists / Q000737:chemistry* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000378:metabolism
D011448:Prostaglandin Antagonists; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C036293:prostaglandin D2 receptor