title: Nutrition and physical activity and chronic disease prevention: research strategies and recommendations.
abstract: A shortage of credible information exists on practical dietary and physical activity patterns that have potential to reverse the national obesity epidemic and reduce the risk of major cancers and other chronic diseases. Securing such information is a challenging task, and there is considerable diversity of opinion concerning related research designs and priorities. Here, we put forward some perspectives on useful methodology and infrastructure developments for progress in this important area, and we list high-priority research topics in the areas of 1) assessment of nutrient intake and energy expenditure; 2) development of intermediate outcome biomarkers; 3) enhancement of cohort and cross-cultural studies; and 4) criteria for and development of full-scale nutrition and physical activity intervention trials.
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, M3-A410, Seattle, WA 98109-1024, USA. rprentic@fhcrc.org
authors.forename: Ross L
authors.initials: RL
authors.lastname: Prentice
authors.forename: Walter C
authors.initials: WC
authors.lastname: Willett
authors.forename: Peter
authors.initials: P
authors.lastname: Greenwald
authors.forename: David
authors.initials: D
authors.lastname: Alberts
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.forename: Norman F
authors.initials: NF
authors.lastname: Boyd
authors.forename: Tim
authors.initials: T
authors.lastname: Byers
authors.forename: Steven K
authors.initials: SK
authors.lastname: Clinton
authors.forename: Gary
authors.initials: G
authors.lastname: Fraser
authors.forename: Laurence
authors.initials: L
authors.lastname: Freedman
authors.forename: David
authors.initials: D
authors.lastname: Hunter
authors.forename: Victor
authors.initials: V
authors.lastname: Kipnis
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Kristal
authors.forename: Alan
authors.initials: A
authors.lastname: Kristal
authors.forename: Johanna W
authors.initials: JW
authors.lastname: Lampe
authors.forename: Anne
authors.initials: A
authors.lastname: McTiernan
authors.forename: John
authors.initials: J
authors.lastname: Milner
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Patterson
authors.forename: John D
authors.initials: JD
authors.lastname: Potter
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Arthur
authors.initials: A
authors.lastname: Schatzkin
authors.forename: Allison
authors.initials: A
authors.lastname: Yates
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Yetley
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002908:Chronic Disease; D015331:Cohort Studies; D018849:Controlled Clinical Trials as Topic; D003431:Cross-Cultural Comparison; D002149:Energy Intake; D004734:Energy Metabolism; D005247:Feeding Behavior; D006801:Humans; D009043:Motor Activity; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D017063:Outcome Assessment, Health Care; D011322:Primary Prevention / Q000379:methods*; D012107:Research Design
chemical_list: D015415:Biomarkers