APOE-dependent PET patterns of brain activation in Alzheimer disease.
Using H2(15)O PET, the authors imaged 13 patients with Alzheimer disease (AD) while performing a serial nonverbal recognition memory task. Patterns of brain activation differed as a function of APOE genotype: epsilon4 carriers exhibited lower activation in the left lingual gyrus and higher activation in left cuneus, precuneus, parahippocampal, and right precentral gyrus. The APOE genotype seems to play a role in cerebral physiologic activity even after onset of clinical manifestations of AD.
Scarmeas
N
N
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University; New York, NY 10032, USA. ns257@columbia.edu
Anderson
K E
KE
Hilton
J
J
Park
A
A
Habeck
C
C
Flynn
J
J
Tycko
B
B
Stern
Y
Y
D017668:Age of Onset; D000483:Alleles; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D049268:Positron-Emission Tomography
D053327:Apolipoprotein E4; D001057:Apolipoproteins E