title: The Nissen fundoplication: indication, technical aspects and postoperative outcome.
abstract: BACKGROUND
  Gastroesophageal reflux disease (GERD) is the most common foregut disease, with a great impact on quality of life and with intestinal, respiratory and cardiac symptoms and implications of carcinogenesis of the oesophagus. Medical therapy often fails, due to the complex pathophysiology of GERD. Surgery can cure the disease, since it is able to restore the anti-reflux barrier. It improves quality of life and prevents carcinogenesis.
  
  
  METHODS
  Review of the literature and presentation of our own experience and data in a series of more than 4,000 evaluated patients referred for suspected reflux disease, of whom 382 have been operated on.
  
  
  CONCLUSIONS
  The laparoscopic Nissen fundoplication is the most commonly used operation technique. It provides good long-term results in the majority of patients. However, due to an increase of outflow resistance of the oesophagus this operation is associated with some postoperative side effects. Therefore, alternative anti-reflux procedures may be indicated in selected patients.
authors.affiliation: Department of General and Transplantation Surgery, University Hospital of Innsbruck, Innsbruck, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Wykypiel
authors.forename: G J
authors.initials: GJ
authors.lastname: Wetscher
authors.forename: P
authors.initials: P
authors.lastname: Klingler
authors.forename: K
authors.initials: K
authors.lastname: Glaser
mesh_terms: D004938:Esophageal Neoplasms / Q000517:prevention & control; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006801:Humans; D011788:Quality of Life