title: [Dioxin emissions and soft-tissue sarcoma: results of a population-based case-control study].
abstract: BACKGROUND
  In 1998, the French Ministry of Environment revealed that of 71 French municipal solid waste incinerators processing more than 6 metric tons of material per hour, dioxin emission from 15 of them was above the 10 ng international toxic equivalency factor/m3 (including Besançon, emitting 16.3 ng international toxic equivalency factor/m3) which is substantially higher than the 0.1 international toxic equivalency factor/m3 prescribed by a European directive of 1994. In 2000, a macrospatial epidemiological study undertaken in the administrative district of Doubs, identified two significant clusters of soft-tissue sarcoma and non Hodgkin lymphoma in the vicinity of the municipal solid waste incinerator of Besançon. This microspatial study (at the Besançon city scale), was designed to test the association between the exposure to dioxins emitted by the municipal solid waste incinerator of Besançon and the risk of soft-tissue sarcoma.
  
  
  METHODS
  Ground-level concentrations of dioxin were modeled with a dispersion model (Air Pollution Control 3 software). Four increasing zones of exposure were defined. For each case of soft tissue sarcoma, ten controls were randomly selected from the 1990 census database and matched for gender and age. A geographic information system allowed the attribution of a dioxin concentration category to cases and controls, according to their place of residence.
  
  
  RESULTS
  Thirty-seven cases of soft tissue sarcoma were identified by the Doubs cancer registry between 1980 and 1995, corresponding to a standardized incidence (French population) of 2.44 per 100,000 inhabitants. Compared with the least exposed zone, the risk of developing a soft tissue sarcoma was not significantly increased for people living in the more exposed zones.
  
  
  CONCLUSIONS
  Before definitely concluding that there is no relationship between the exposure to dioxin released by a solid waste incinerator and soft tissue sarcoma, a nationwide investigation based on other registries should be conducted.
authors.affiliation: Département de Santé publique, Biostatistiques et Epidémiologie, Faculté de Médecine de Besançon.
authors.forename: N
authors.initials: N
authors.lastname: Floret
authors.forename: F
authors.initials: F
authors.lastname: Mauny
authors.forename: B
authors.initials: B
authors.lastname: Challier
authors.forename: J-Y
authors.initials: JY
authors.lastname: Cahn
authors.forename: F
authors.initials: F
authors.lastname: Tourneux
authors.forename: J-F
authors.initials: JF
authors.lastname: Viel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D004147:Dioxins / Q000009:adverse effects*; D004781:Environmental Exposure; D005260:Female; D005602:France; D006801:Humans; D017745:Incineration; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012509:Sarcoma / Q000139:chemically induced*; D012983:Soft Tissue Neoplasms / Q000139:chemically induced*
chemical_list: D004147:Dioxins