[The expression of nm23-H1 in the investing papilloma and it's cancerated tissue of nasal cavity and parasinuses].
OBJECTIVE
To investigate the role of the nm23-H1 protein in the development of investing papilloma and it's cancerated tissue in nasal cavity and parasinuses.


METHODS
The expression of nm23-H1 protein was measured by immunohistochemistry in twenty-five cases with investing papilloma and twenty-one cases with cancerated investing papilloma in nasal cavity and parasinuses and fourteen cases with chronic sinusitis.


RESULTS
The expression of nm23-H1 in the investing papilloma was higher than that in cancerated investing papilloma tissue, the positive rate was 72% and 42% respectively in the two groups, P < 0.05. The expression of nm23-H1 in the investing papilloma was higher than in the chronic sinusitis, the positive rate of the latter was 14.3%, P < 0.05.


CONCLUSIONS
The lower expression the nm23-H1 protein in the cancerated tissue of investing papilloma was related to the infiltration and canceration.
Li
Tianying
T
Department of Otorhinolaryngology, the First Affiliated Hospital of Sun-Yat-Sen University, Guangzhou, 510080, China.
Xia
Liangping
L
Meng
Qingxiang
Q
Chen
Jing
J
D000328:Adult; D000368:Aged; D005260:Female; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009669:Nose Neoplasms / Q000235:genetics* / Q000378:metabolism; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis*; D018308:Papilloma, Inverted / Q000235:genetics* / Q000378:metabolism
D054778:NM23 Nucleoside Diphosphate Kinases; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase