title: [Meta analysis of the relationship between tumorigenesis of oral squamous cell carcinoma and human papillomavirus infection].
abstract: OBJECTIVE
  Previous researches showed that human papillomavirus (HPV) infection was closely related to tumorigenesis of oral squamous cell carcinoma (OSCC). But the results of these studies have great differences because of different research methods. This study was to evaluate synthetically the relationship between OSCC of Chinese and HPV infection by meta analysis.
  
  
  METHODS
  From Jan. 1990 to Apr. 2003, 44 references reported about the relationship between tumorigenesis of OSCC of Chinese and HPV infection were collected from Chinese Biomedical Literature Analysis and Retrieval System for Compact Disc (CBMdisc). There were 10 references accorded with research criteria which was case-control study, and detected by polymerase chain reaction (PCR). Fisher and meta analysis were used to quantitatively and qualitatively analyze these references synthetically.
  
  
  RESULTS
  The synthetic qualitative analysis by Fisher showed there was significant association between the tumorigenesis of OSCC and HPV infection (P< 0.005). The synthetic quantitative analysis by meta analysis revealed that the combined odds ratioes (ORc) for HPV, and HPV16 infection of OSCC were 8.89 (3.62-21.80), and 6.81 (2.18-21.32) times that of normal oral mucosa. The mean positive rates of HPV, and HPV16 detection in OSCC were 49.02% (36.48%-61.57%),and 45.74% (31.94%-59.54%) higher than that of normal oral mucosa.
  
  
  CONCLUSIONS
  Human papillomavirus infection, especially HPV16, will increase the risk of tumorigenesis of OSCC.
authors.affiliation: Department of Stomatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. lisusu@tom.com
authors.forename: An-Xun
authors.initials: AX
authors.lastname: Wang
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Xu
authors.forename: Ke-Qian
authors.initials: KQ
authors.lastname: Lia
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Zhong
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000821:virology*; D006801:Humans; D015201:Meta-Analysis as Topic; D009062:Mouth Neoplasms / Q000821:virology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections; D012307:Risk Factors