A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice.
Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. These results strongly suggest that FTY720 is a promising candidate for treatment of human atopic dermatitis.
Kohno
Takeyuki
T
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. kohno@pharm.setsunan.ac.jp
Tsuji
Takumi
T
Hirayama
Kaori
K
Watabe
Kazuhito
K
Matsumoto
Akiko
A
Kohno
Tomoko
T
Fujita
Tetsuro
T
D000818:Animals; D003876:Dermatitis, Atopic / Q000276:immunology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004817:Epidermis / Q000187:drug effects / Q000276:immunology; D000068876:Fingolimod Hydrochloride; D007073:Immunoglobulin E / Q000097:blood; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011409:Propylene Glycols / Q000494:pharmacology*; D013047:Specific Pathogen-Free Organisms; D013110:Sphingosine / Q000031:analogs & derivatives; D013997:Time Factors
D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D007073:Immunoglobulin E; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine