title: Osteonecrosis in children with severe acute respiratory syndrome.
abstract: Osteonecrosis is a debilitating bone disease affecting adults who have recovered from severe acute respiratory syndrome in Hong Kong and China, but there are no data on its prevalence in children. We report 5 children with magnetic resonance imaging evidence of osteonecrosis. In view of the high prevalence and asymptomatic presentation of osteonecrosis, we suggest magnetic resonance imaging screening for osteonecrosis in children with severe acute respiratory syndrome.
authors.affiliation: Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Kwun Tong, Hong Kong Special Administrative Region, China. desmondcwchan@hotmail.com
authors.forename: Chun-Wing
authors.initials: CW
authors.lastname: Chan
authors.forename: Wa-Keung
authors.initials: WK
authors.lastname: Chiu
authors.forename: Chak-Chung
authors.initials: CC
authors.lastname: Chan
authors.forename: Eudora Y
authors.initials: EY
authors.lastname: Chow
authors.forename: Ho-Man
authors.initials: HM
authors.lastname: Cheung
authors.forename: Patricia Lai-Sheung
authors.initials: PL
authors.lastname: Ip
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents; D002648:Child; D015331:Cohort Studies; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006621:Hip Joint / Q000473:pathology; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010020:Osteonecrosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D011239:Prednisolone / Q000627:therapeutic use; D018570:Risk Assessment; D045473:Severe acute respiratory syndrome-related coronavirus / Q000302:isolation & purification; D012494:Sampling Studies; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D012720:Severity of Illness Index
chemical_list: D000900:Anti-Bacterial Agents; D011239:Prednisolone