title: [Successful treatment of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b meningitis with high-dose ceftriaxone administration].
abstract: Haemophilus influenzae type b (Hib) is the most frequent pathogen of bacterial meningitis in Japanese children. The prevalence of beta-lactamase-negative ampicillin-resistant (BLNAR) Hib strain has been increasing in recent years. Furthermore, antibiotic activities of cefotaxime (CTX) and ceftriaxone (CTRX) have decreased against some of those BLNAR strains. We report a case of one-year-old boy who suffered from meningitis caused by BLNAR Hib. The MICs of CTX and CTRX for the strain isolated from cerebrospinal fluid was 1.0 and 0.5 microg/ml, respectively. The patient was administered high-dose CTRX (150 mg/kg/day) and recovered completely without any sequela. The high-dose CTRX administration may be a considerable choice of the treatment of BLNAR meningitis.
authors.affiliation: Division of Infectious Diseases, Chiba Children's Hospital.
authors.forename: Fusayo
authors.initials: F
authors.lastname: Sudo
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hoshino
authors.forename: Naruhiko
authors.initials: N
authors.lastname: Ishiwada
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kohno
mesh_terms: D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002443:Ceftriaxone / Q000008:administration & dosage*; D019741:Haemophilus influenzae type b / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D007223:Infant; D008297:Male; D008583:Meningitis, Haemophilus / Q000188:drug therapy*; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D001618:beta-Lactamases