Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy.
The nido-carborane lipid, which has a double-tailed moiety, was synthesized from heptadecanol in 5 steps. Analysis in a transmission electron microscope by negative staining with uranyl acetate showed that the lipid formed a stable vesicle in which calcein was encapsulated. The lipid was incorporated into distearoylphosphatidylcholine (DSPC) liposomes at a very high concentration.
Nakamura
Hiroyuki
H
Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan. hiroyuki.nakamura@gakushuin.ac.jp
Miyajima
Yusuke
Y
Takei
Toshiaki
T
Kasaoka
Satoshi
S
Maruyama
Kazuo
K