title: Maternal anaphylaxis and fetal brain damage after intrapartum chemoprophylaxis.
abstract: We report a case of maternal anaphylaxis following intrapartum chemoprophylaxis. The term fetus developed severe brain damage as a consequence of intrapartum asphyxia. The lesions resulted from maternal hypotension following anaphylaxis. We discuss the feto-maternal risks and the controversial treatment of such a condition. The increasing number of penicillin-treated parturients will result in further cases of maternal anaphylaxis than previously found.
authors.affiliation: Neonatal Intensive Care Unit, Azienda Policlinico, Modena, Italy. berardi.a@policlinico.mo.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Berardi
authors.forename: Katia
authors.initials: K
authors.lastname: Rossi
authors.forename: Francesca
authors.initials: F
authors.lastname: Cavalleri
authors.forename: Angela
authors.initials: A
authors.lastname: Simoni
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Aguzzoli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Masellis
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ferrari
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000009:adverse effects*; D000707:Anaphylaxis / Q000139:chemically induced*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000209:etiology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin