Spatial representation in the entorhinal cortex.
As the interface between hippocampus and neocortex, the entorhinal cortex is likely to play a pivotal role in memory. To determine how information is represented in this area, we measured spatial modulation of neural activity in layers of medial entorhinal cortex projecting to the hippocampus. Close to the postrhinal-entorhinal border, entorhinal neurons had stable and discrete multipeaked place fields, predicting the rat's location as accurately as place cells in the hippocampus. Precise positional modulation was not observed more ventromedially in the entorhinal cortex or upstream in the postrhinal cortex, suggesting that sensory input is transformed into durable allocentric spatial representations internally in the dorsocaudal medial entorhinal cortex.
Fyhn
Marianne
M
Centre for the Biology of Memory, Medical-Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Molden
Sturla
S
Witter
Menno P
MP
Moser
Edvard I
EI
Moser
May-Britt
MB
D000200:Action Potentials; D000818:Animals; D001931:Brain Mapping; D004567:Electrodes, Implanted; D018728:Entorhinal Cortex / Q000166:cytology / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D008297:Male; D008568:Memory; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D013028:Space Perception