Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy.
Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-1-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-alpha levels and the amelioration of clonogenic parameters.
Isgrò
Antonella
A
Division of Allergy and Clinical Immunology, University of Rome La Sapienza, Italy.
Mezzaroma
Ivano
I
Aiuti
Alessandro
A
Fantauzzi
Alessandra
A
Pinti
Marcello
M
Cossarizza
Andrea
A
Aiuti
Fernando
F
D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D017209:Apoptosis; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D015497:HIV-1; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology*; D006801:Humans; D019014:fas Receptor / Q000032:analysis
D019380:Anti-HIV Agents; D019014:fas Receptor