title: [The T-lymphocytes subsets expression in the human recurrent nasal polyps].
abstract: OBJECTIVE
  To investigate the expression of T-lymphocyte subsets (CD4+, CD8+ and CD45RO+ cells) in human recurrent nasal polyps.
  
  
  METHODS
  Nasal polyps tissue samples and peripheral blood were obtained from 17 patients, normal human inferior turbinate mucosa and peripheral blood were obtained as well. Flow cytometry was adopted to detect the expression of surface markers of the T-lymphocytes. All data were analyzed with t-test.
  
  
  RESULTS
  There were significantly large number of CD4+, and CD45RO+ cells in the tissue of recurrent nasal polyps. The expression percentage of CD3+ CD4+ cells was significantly higher than that of CD3+ CD8+ cells. Ratio of CD3+ CD4+/CD3+ CD8+ was 1.956 +/- 0.093.
  
  
  CONCLUSIONS
  There were generous of T-lymphocytes expression in human recurrent nasal polyps. The ratio of the T-lymphocytes subsets was abnormal high than the usual and this indicated the immunological function were in disorder in the local area. The abnormally higher expression of CD3+ CD4+ cells in the local area may play an important role in the recurrence of human nasal polyps.
authors.affiliation: Department of Otolaryngology, Railway Hospital of Shenzhen, Shenzhen, 518000, China.
authors.forename: Liechun
authors.initials: L
authors.lastname: He
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.forename: Jianbo
authors.initials: J
authors.lastname: Shi
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000276:immunology*; D012008:Recurrence; D016176:T-Lymphocyte Subsets / Q000276:immunology*