[Effect of antiischemic therapy in immediate period after mammary coronary bypass surgery on left ventricular contractility and conduit blood flow. Randomized controlled study].
OBJECTIVE
To assess influence of 2-week course therapy with atenolol, nebivolol, and verapamil on systolic and diastolic left ventricular function and mammary coronary blood flow in early period after revascularization.


METHODS
Patients (n=113) after mammary coronary bypass grafting.


METHODS
Echocardiographic characteristics of systolic and diastolic left ventricular function, and blood flow through mammary coronary grafts were measured before and after treatment with study drugs.


RESULTS
In placebo treated patients isovolumic relaxation time (IVRT) and late diastolic filling phase (A) increased, while velocity characteristics of mammary-coronary blood flow decreased. Administration of atenolol, nebivolol, and verapamil was associated with significant increases of left ventricular ejection fraction, stroke volume, cardiac output, IVRT, peak diastolic velocity, flow through mammary coronary grafts and their lumen diameter, and decrease of E/A ratio.


CONCLUSIONS
Administration of atenolol, nebivolol, and verapamil in early postoperative period after mammary coronary bypass grafting improved systolic and diastolic function of the left ventricle, and blood flow through mammary coronary grafts. None of the studied drugs had significant advantage over others.
Tepliakov
A T
AT
Research Institute for Cardiology of the Research Centre of RAMS, Siberian Branch; ul. Kievskaya, 111, 634012 Tomsk, Russia.
Mamchur
S E
SE
Vecherskiĭ
Iu Iu
IuIu
Bukhovets
I L
IL
Vorozhtsova
I N
IN
Bezliak
V V
VV
D001026:Coronary Artery Bypass; D003971:Diastole / Q000187:drug effects; D006439:Hemodynamics; D006801:Humans; D013318:Stroke Volume / Q000187:drug effects; D013599:Systole