[Intraoperative 125I brachytherapy combined with chemotherapy for pancreatic cancer].
OBJECTIVE
To evaluate the efficacy, toxicity and survival of intraoperative 125I brachytherapy combined with chemotherapy for advanced pancreatic cancer.


METHODS
Thirty-six patients with advanced pancreatic cancer were randomized to two groups: brachy-chemotherapy group (n = 18) and control group (n = 18). For the combined group, intraoperative 125I implantation and gemcitabine, 5-Fu were given. For the control group, intratumoral injection of absolute alcohol was done.


RESULTS
The CR + PR rate of brachy-chemotherapy group was 38.9% with pain relief in 77.8%, while that of control group was 0 with pain relief in 22.2% (P < 0.05). Although there were some toxicity in brachy-chemotherapy group, treatment was well tolerated. The 6-, 12-month survival rates of brachy-chemotherapy group were 71.4% and 21.4% and those of control group were 38.5% and 7.7%, respectively. The median survival time was 10.6 months and 5.2 months for the two groups, between which the difference was significant (P < 0.05).


CONCLUSIONS
Interoperative 125I brachytherapy combined with chemotherapy for advanced pancreatic cancer can control tumor, relieve pain and improve quality of life. It is safe and effective.
Wang
Dong-min
DM
Department of Surgery, Peking University First Hospital, Beijing 100034, China. wangdongmin@csco.org.cn
Liu
Yin-hua
YH
Yu
Shi-ping
SP
Duan
Xue-ning
XN
Yang
Yin-mo
YM
Wan
Yuan-lian
YL
Zhou
Gang
G
Shen
Wen-jiang
WJ
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001918:Brachytherapy; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007432:Intraoperative Period; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011788:Quality of Life; D015996:Survival Rate; D000093542:Gemcitabine
D007457:Iodine Radioisotopes; D003841:Deoxycytidine; D005472:Fluorouracil; D000093542:Gemcitabine