title: Mapping of multiple quantitative trait loci affecting bovine spongiform encephalopathy.
abstract: A whole-genome scan was conducted to map quantitative trait loci (QTL) for BSE resistance or susceptibility. Cows from four half-sib families were included and 173 microsatellite markers were used to construct a 2835-cM (Kosambi) linkage map covering 29 autosomes and the pseudoautosomal region of the sex chromosome. Interval mapping by linear regression was applied and extended to a multiple-QTL analysis approach that used identified QTL on other chromosomes as cofactors to increase mapping power. In the multiple-QTL analysis, two genome-wide significant QTL (BTA17 and X/Y(ps)) and four genome-wide suggestive QTL (BTA1, 6, 13, and 19) were revealed. The QTL identified here using linkage analysis do not overlap with regions previously identified using TDT analysis. One factor that may explain the disparity between the results is that a more extensive data set was used in the present study. Furthermore, methodological differences between TDT and linkage analyses may affect the power of these approaches.
authors.affiliation: Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, United Kingdom.
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.forename: Dirk-Jan
authors.initials: DJ
authors.lastname: De Koning
authors.forename: Jules
authors.initials: J
authors.lastname: Hernández-Sánchez
authors.forename: Chris S
authors.initials: CS
authors.lastname: Haley
authors.forename: John L
authors.initials: JL
authors.lastname: Williams
authors.forename: Pamela
authors.initials: P
authors.lastname: Wiener
mesh_terms: D000818:Animals; D002417:Cattle; D002874:Chromosome Mapping; D016001:Confidence Intervals; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics*; D005819:Genetic Markers; D016678:Genome; D005838:Genotype; D008957:Models, Genetic; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers