[Regulation of hypoxia-inducible factor-1alpha expression].
Hypoxia-inducible factor-1(HIF-1) is a major transcriptional regulator of O2 homeostasis, and plays a key role in physiology, and pathophysiology, and also in tumor pathogenesis. HIF-1 is a heterodimer consisting of HIF-1alpha and beta subunits. The activities of HIF-1 is mainly determined by HIF-1alpha, which transcriptional activity and DNA-binding ability were strictly regulated by O2 concentration, and other stimuli such as metalion, nitric oxide(NO), reactive oxygen species (ROS), and many growth factors. Here we reviewed the mechanisms of regulation of HIF-1alpha expression.
Du
Ke-Ming
KM
Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, 200025, PR China. dkem@163.com
Chen
Guo-Qiang
GQ
Chen
Zhu
Z
D000818:Animals; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009569:Nitric Oxide / Q000378:metabolism*; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D015032:Zinc / Q000378:metabolism
D004268:DNA-Binding Proteins; C497442:HIF1A protein, human; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D009569:Nitric Oxide; D015032:Zinc; D010100:Oxygen