[Detection of Epstein-Barr virus in T cell lymphoma and clinicopathologic analysis].
BACKGROUND
To study the relationship of Epstein-Barr virus (EBV) and T cell lymphoma.


METHODS
Sixty cases of T cell lymphomas were examined for the presence of EBV using in situ hybridization for EBV encoded RNA (EBERs).


RESULTS
EBERs were detected in tumor cells in 37(69.8%) of 53 cases with peripheral T cell lymphoma, but in none of seven cases of precursor T lymphoblastic lymphoma. The total detected EBERs were 37(61.6%) in 60 cases of T cell lymphomas. By Revised European-American Lymphoma(REAL) classification, EBERs were detected in 2/2 angioimmuno-blastic T cell lymphoma,17/18 angiocentric lymphoma, 4/6 anaplastic large cell lymphoma and 14/27 peripheral T cell lymphoma, unspecified (51.9%). The frequency of EBERs among the extranodal peripheral T cell lymphoma was higher than the nodal (P less than 0.01) there was no significant correlation with the sex, age and clinical stage.


CONCLUSIONS
This study indicated that high incidence of EBV was observed in peripheral T cell lymphoma, with predilection for angiocentric lymphoma and extranodal presentation.
He
Zu-gen
ZG
Department of Pathology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China.
Huang
Yan-ping
YP
Guo
Xiu-chan
XC
Lin
Dong-mei
DM
Zeng
Yi
Y
D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured
D004279:DNA, Viral