title: [Detection and potential function of anti-FSH antibodies in patients with spermatogenesis dysfunction].
abstract: OBJECTIVE
  To detect the anti-FSH antibody using ELISA, and further probe into the role of anti-FSH in infertile patients.
  
  
  METHODS
  The anti-FSH antibody was detected using ELISA in the serum of patients with spermatogenesis dysfunction, of infertile patients with normal sperm density and motility, and of normal fertile males.
  
  
  RESULTS
  The positive rate of anti-FSH antibody in the patients with oligospermia and/or asthenospermia [22.4% (22/98)] was significantly higher than that in the normal fertile [4% (2/50)] (P < 0.05) and that in the infertile patients with normal sperm density and motility [6.7% (2/30)] (P < 0.05). The positive rate of anti-FSH antibody in the patients with oligospermia and/or asthenospermia was lower than that in the patients with azoospermia [54.5% (12/22)] (P < 0.05). There was no significant difference in the positive rate between the normal control and the sterile males with normal sperm density and motility.
  
  
  CONCLUSIONS
  The anti-FSH antibody may be an important factor to cause spermatogenesis dysfunction by combining FSH to form immune compound and depress the activation of FSH.
authors.affiliation: Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA4, Nanjing, Jiangsu 210002, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Yao
authors.forename: Leilei
authors.initials: L
authors.lastname: Zhang
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Cui
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Wang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000906:Antibodies / Q000097:blood*; D005640:Follicle Stimulating Hormone / Q000276:immunology*; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000276:immunology*; D008297:Male; D013091:Spermatogenesis
chemical_list: D000906:Antibodies; D005640:Follicle Stimulating Hormone