title: Combined vaccination of live 1B Chlamydophila abortus and killed phase I Coxiella burnetii vaccine does not destroy protection against chlamydiosis in a mouse model.
abstract: Q fever and chlamydiosis often affect ovine and caprine flocks simultaneously or successively. Combination vaccines effective against these 2 diseases would be of great value in veterinary medicine. Unfortunately, the current effective vaccines are a live vaccine for chlamydiosis and killed vaccine for Q fever. Vaccination of mice with live chlamydiosis vaccine 1B and killed phase I vaccine against Q fever at 2 points on the back at the same time produced good protection against chlamydial abortion. This suggests that it may be possible to vaccinate ewes and goats against chlamydiosis and Q fever simultaneously.
authors.affiliation: Unité de Pathologie Infectieuse et Immunologie, INRA-Centre de Tours, Nouzilly 37380 France.
authors.forename: Abdessalem
authors.initials: A
authors.lastname: Rekiki
authors.forename: Amel
authors.initials: A
authors.lastname: Bouakane
authors.forename: Annie
authors.initials: A
authors.lastname: Rodolakis
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines; D023501:Chlamydophila / Q000276:immunology*; D023521:Chlamydophila Infections / Q000517:prevention & control / Q000662:veterinary*; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology*; D014611:Vaccination / Q000662:veterinary; D017778:Vaccines, Combined; D015164:Vaccines, Inactivated
chemical_list: D001428:Bacterial Vaccines; D017778:Vaccines, Combined; D015164:Vaccines, Inactivated