[Does the catalepsy phenomenon reflect the functional dopaminergic activity in pharmacological investigations?].
The dynamics of spontaneous and haloperidol-induced catalepsy in mice has been studied. It is established that the degree of manifestation of the spontaneous catalepsy is directly related to the number of manipulations (mice standings in the "lector position"). At the same time, the intensity of catalepsy (both spontaneous and haloperidol-induced) was not related to the mice response to apomorphine injections. It is concluded that spontaneous catalepsy rather insignificantly influences the results of pharmacological tests, but this factor has to be taken into account in the study of physiological mechanisms. The absence of correlations between catalepsy manifestations and the apomorphine test results is indicative of complexity of the mechanism of this disorder and cannot be attributed entirely to the violation of dopaminergic processes in CNS.
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D000818:Animals; D014150:Antipsychotic Agents; D001058:Apomorphine / Q000494:pharmacology; D002375:Catalepsy / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D006220:Haloperidol; D008297:Male; D051379:Mice; D015398:Signal Transduction / Q000187:drug effects*
D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine