title: Hemophagocytic syndrome and Burkholderia cepacia splenic microabscesses in a child with chronic granulomatous disease.
abstract: Hemophagocytic syndrome, splenic microabscesses and pulmonary cavitary lesions were presented in a 17-month-old boy with prolonged fever, hepatosplenomegaly and a history of tuberculous lymphadenitis. Clinical course mimicked tuberculosis. Blood cultures were negative. Ultrasound-guided, percutaneous aspiration from splenic microabscesses grew Burkholderia cepacia. He was treated successfully with trimethoprim-sulfamethoxazole. This child with chronic granulomatous disease had an unusual clinical manifestation of B. cepacia infection.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Sayomporn
authors.initials: S
authors.lastname: Sirinavin
authors.forename: Chonnamet
authors.initials: C
authors.lastname: Techasaensiri
authors.forename: Samart
authors.initials: S
authors.lastname: Pakakasama
authors.forename: Malai
authors.initials: M
authors.lastname: Vorachit
authors.forename: Rattanaporn
authors.initials: R
authors.lastname: Pornkul
authors.forename: Rames
authors.initials: R
authors.lastname: Wacharasin
mesh_terms: D000038:Abscess / Q000188:drug therapy / Q000209:etiology*; D000900:Anti-Bacterial Agents; D019121:Burkholderia Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016956:Burkholderia cepacia / Q000302:isolation & purification*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005500:Follow-Up Studies; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D010587:Phagocytosis; D011859:Radiography; D018570:Risk Assessment; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging / Q000209:etiology*; D013158:Splenic Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D016896:Treatment Outcome; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents