[Morphometric characteristics of microcirculatory bed of olfactory bulbs in the desympathized albino rat].
To detect the effect of postnatal chemical desympathization on morphometric characteristics of the vessels of olfactory bulbs in albino rat early postnatal ontogenesis, the study was performed using the histochemical method for demonstration of alkaline phosphatase activity, which is a marker of vascular endothelium, and vessel diameter and relative density were measured during the first three months of life. Desympathization was induced in rats by daily intraperitoneal injection of 60-70 mg/kg of guanethidine during postnatal days 1 to 30. The vessel diameter was found to increase after day 30 simultaneously with the changes of the vascular wall of vessels (irregular contour and non-uniform vasodilatation, non-uniform decrease in alkaline phosphatase activity). Relative density of the vessels was reduced one month after desympathization. After two months this parameter remained depressed in the peripheral zone of the olfactory bulbs, while in the central zone it was not different from that one in control group.
Nevzorova
M N
MN
Tiatenkova
N N
NN
Filimonov
V I
VI
D000375:Aging / Q000473:pathology*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D004730:Endothelium, Vascular / Q000201:enzymology / Q000254:growth & development / Q000473:pathology*; D006145:Guanethidine / Q000494:pharmacology; D008833:Microcirculation / Q000201:enzymology / Q000254:growth & development / Q000473:pathology; D009830:Olfactory Bulb / Q000098:blood supply* / Q000254:growth & development / Q000473:pathology; D051381:Rats; D013563:Sympathectomy, Chemical
D000469:Alkaline Phosphatase; D006145:Guanethidine