title: Surgical treatment of seizures from the peri-Sylvian area by perinatal insult: a case report of ictal hypersalivation.
abstract: OBJECTIVES AND IMPORTANCE: It is important to evaluate the seizure manifestation of epilepsy before surgical planning. A patient with partial epilepsy manifesting hypersalivation who underwent resection of the epileptogenic foci with satisfactory postoperative seizure control is reported.
  
  
  METHODS
  A 26-year-old man, with a history of perinatal asphyxia, started having medically intractable partial epilepsy at the age of 10 years. His seizure was characterized by throat discomfort followed by hypersalivation. Brain MRI showed an atrophic lesion around the peri-Sylvian area. Scalp recorded EEG did not demonstrate robust epileptiform activity localized enough to define the epileptogenic zone. The patient underwent invasive recording by multiple subdural electrode grids, which showed that the seizure arose from the left anterior frontal operculum. After resection of epileptogenic opercular cortex, the seizures disappeared with no additional neurological deficits.
  
  
  CONCLUSIONS
  Although the responsible sites for ictal drooling are distributed in multiple areas including insula, medial temporal area and operculum, the seizure can be successfully controlled by focus resection of the frontal opercular area in a selected patient with careful presurgical evaluation.
authors.affiliation: Human Brain Research Center, Departmrnt of Neurology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Satow
authors.forename: A
authors.initials: A
authors.lastname: Ikeda
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: J
authors.initials: J
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Takayama
authors.forename: M
authors.initials: M
authors.lastname: Matsuhashi
authors.forename: N
authors.initials: N
authors.lastname: Mikuni
authors.forename: J
authors.initials: J
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Shibasaki
authors.forename: S
authors.initials: S
authors.lastname: Miyamoto
authors.forename: N
authors.initials: N
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D001238:Asphyxia Neonatorum / Q000150:complications*; D001921:Brain / Q000473:pathology; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology / Q000601:surgery*; D005625:Frontal Lobe / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures / Q000379:methods*; D012798:Sialorrhea / Q000209:etiology; D016896:Treatment Outcome