Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD.
Interactions between environmental and genetic factors may contribute to neurodegenerative disease. In this issue of Neuron, Calon et al. report that a diet low in an essential omega-3 polyunsaturated fatty acid (docosahexaenoic acid) depletes postsynaptic proteins and exacerbates behavioral alterations in a transgenic mouse model of Alzheimer's disease.
Mucke
Lennart
L
Gladstone Institute of Neurological Disease, University of California, San Francisco, PO Box 419100, 94103, USA.
Pitas
Robert E
RE
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism / Q000627:therapeutic use; D018384:Oxidative Stress / Q000235:genetics
D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D004281:Docosahexaenoic Acids