title: Sustained release of doxycycline for the treatment of peri-implantitis: randomised controlled trial.
abstract: With the increased use of osseointegrated implants and with many implants functioning for a long time, the treatment of peri-implantitis has become important. Animal studies and clinical case reports have shown that the principle of guided bone regeneration can be applied to the surgical treatment of moderate to profound loss of bone around the implant, but we have found no published clinical studies.
  
  
  METHODS
  Twenty-eight patients whose ages ranged from 25 to 78 years and who had a total of 48 peri-implant defects were examined at baseline (week 0) and after 18 weeks. This included the recording of bleeding on probing, pocket probing depths, and probing attachment levels at six sites for each tooth. For 2-18 weeks before week 0 all patients had been treated for peri-implantitis, including motivation, instruction in oral hygiene, and implant scaling with a hand plastic instrument. They were then randomly allocated to continue with this treatment or to have in addition mechanical debridement and local application of Atridox trade mark which slowly release doxycycline.
  
  
  RESULTS
  Patients treated with Atridox trade mark showed a significantly greater gain in mean (S.D.) probing attachment levels than those not treated with Atridox. Only subjects treated with Atridox had a significant gain in mean bleeding on probing (P = 0.001). Application of the biodegradable sustained release device after initial periodontal treatment resulted in a significant gain in mean probing attachment levels in the Atridox trade mark group and a significant reduction in pocket probing depths. There was also a significant difference in mean probing attachment levels (0.6mm).
authors.affiliation: Department of Cranio-Maxillofacial Surgery, University of Münster, Waldeyerstrasse 30, D-48129 Münster, Germany. buchtea@uni-muenster.de
authors.forename: André
authors.initials: A
authors.lastname: Büchter
authors.forename: Ulrich
authors.initials: U
authors.lastname: Meyer
authors.forename: Birgit
authors.initials: B
authors.lastname: Kruse-Lösler
authors.forename: Ulrich
authors.initials: U
authors.lastname: Joos
authors.forename: Johannes
authors.initials: J
authors.lastname: Kleinheinz
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003646:Debridement; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous / Q000009:adverse effects*; D004318:Doxycycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy* / Q000601:surgery; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004318:Doxycycline