Synthesis of an unusual branched-chain sugar, 5-C-methyl-L-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglycoside antibiotics.
The syntheses of a challenging branched-chain sugar and several L-sugars have been accomplished. Their application in studies of the antibacterial activity of pyranmycins is reported, which could provide new strategies for the future design of aminoglycoside antibiotics.
Wang
Jinhua
J
Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan 84322-0300, USA.
Li
Jie
J
Czyryca
Przemyslaw G
PG
Chang
Huiwen
H
Kao
Jeff
J
Chang
Cheng-Wei Tom
CW
D000617:Aminoglycosides / Q000138:chemical synthesis*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D006601:Hexoses / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006601:Hexoses; C475966:Pyranmycin; C010997:idose