title: The use of neoadjuvant chemotherapy to achieve complete surgical resection in recurring supratentorial anaplastic ependymoma.
abstract: BACKGROUND
  Ependymoma is a central nervous system neoplasm that is often managed with surgery and radiotherapy. The benefits of chemotherapy in treating this tumor remain poorly defined.
  
  
  METHODS
  The use of a platinum-based chemotherapy as a neoadjuvant treatment to permit complete surgical resection of a supratentorial anaplastic ependymoma recurring for the third time is described.
  
  
  CONCLUSIONS
  This paper also discusses the possible use of chemotherapy as a strategy that may allow tumor shrinkage and ease tumor resection in giant recurring ependymomas.
authors.affiliation: Pediatric Department, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, CEP 14049-900, Ribeirão Preto, São Paulo, Brazil. elvisvalera@hotmail.com
authors.forename: Elvis Terci
authors.initials: ET
authors.lastname: Valera
authors.forename: Helio Rubens
authors.initials: HR
authors.lastname: Machado
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Santos
authors.forename: Ricardo Santos
authors.initials: RS
authors.lastname: de Oliveira
authors.forename: David
authors.initials: D
authors.lastname: Araújo
authors.forename: Luciano
authors.initials: L
authors.lastname: Neder
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D004806:Ependymoma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D020360:Neoadjuvant Therapy; D015173:Supratentorial Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome