Role of myeloperoxidase index in differentiation of megaloblastic and aplastic anemia.
BACKGROUND
Elevated neutrophil myeloperoxidase may have a role in the diagnosis of megaloblastic erythropoiesis.


OBJECTIVE
To study the differentiating role of myeloperoxidase index in megaloblastic and aplastic anemia.


METHODS
The myeloperoxidase index (MPXI) was studied in 96 patients with megaloblastic and aplastic anemia diagnosed on bone marrow aspiration and biopsy examinations.


METHODS
MPXI was measured with Technicon H1 (Bayer) automated analyzer. Nonparametric Mann-Whitney statistical test was used to compare the MPXI values between groups.


RESULTS
The mean MPXI in megaloblastics and aplastic anemia was 18.3 and 1.8 (p< 0.001) respectively. MPXI> 20 denoted megaloblastic and MPXI <-11.6 denoted aplastic anemia.


CONCLUSIONS
MPXI measurement may assist differentiation of megaloblastic from aplastic anemia, while MPXI> 20 rules out aplastic and MPXI <-11.6 rules out megaloblastic anemia.
Ziaei
Jamal Eivazi
JE
Hematology and Oncology Department, Imam Hospital, Tabriz, Iran. jziaei@hotmail.com
Dastgiri
Saeed
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000175:diagnosis*; D000749:Anemia, Megaloblastic / Q000175:diagnosis*; D002648:Child; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D009195:Peroxidase / Q000032:analysis*
D009195:Peroxidase