title: Innervation of the substantia nigra.
abstract: This review describes inputs to neurons in the substantia nigra and contrasts them with the action of agonists for the putative receptors through which they act. Special emphasis is placed on gamma-aminobutyric acid (GABA) afferents. Dopamine released from the somato-dendritic compartment of dopamine neurons and endocannabinoids released from dopamine and GABA neurons serve as retrograde signals to modulate GABA release. The release may be fostered by Ca(2+) release from intracellular Ca(2+) stores, which in turn may be influenced by the inputs.
authors.affiliation: Institut für Physiologie und Pathophysiologie und IZN, Universität Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany. ulrich.misgeld@pio1.uni-heidelberg.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Misgeld
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D013378:Substantia Nigra / Q000166:cytology* / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid; D004298:Dopamine