[An animal model of alcoholic fatty liver and the prevention and treatment with New Qinggan Decoction].
OBJECTIVE
To establish an animal model of alcoholic fatty liver (AFL) and to observe the prevention and treatment with New Qinggan Decoction (NQGD).


METHODS
Female SD rats were exposed to the mixture of white spirit and corn oil continuously for up to 6 weeks via an intragastric feeding protocol. The pathologic alteration of the liver and the changes of serum lipid were observed, and the effect of NQGD for preventing and treating AFL was studied.


RESULTS
Wide hepatic steatosis was induced in model group rats. Serum triglyceride (TG) and total cholesterol (TC) of the model group were higher than those of the normal group (P<0.01). Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of the model group were higher than those of the normal group (P<0.05). In NQGD group, hepatic steatosis was milder than that in the model group, and serum TG, TC, AST, ALT descended significantly as compared with the model group (P<0.01).


CONCLUSIONS
AFL model of rats established by feeding the mixture of white spirit and corn oil is similar to the episode of the human AFL, and is easy to intervene with medicine. NQGD can prevent the occurrence of AFL in this model.
Hu
Guo-Jie
GJ
Department of Infectious Diseases, General Hospital of Huabei Oil Field, Renqiu, Hebei Province 062552, China. huguojie2002@sina.com
Li
Dian-Gui
DG
Li
Shi-Fang
SF
Li
Zhen-Bin
ZB
Li
Jun-Xia
JX
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005235:Fatty Liver, Alcoholic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D008099:Liver / Q000473:pathology; D008516:Medicine, Chinese Traditional; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase