title: Compound dual radiation action theory for 252Cf brachytherapy.
abstract: The existing dosimetry protocol that uses the concept of RBE for 252Cf brachytherapy contains large uncertainties. A new formula has been developed to correlate the biological effect (i.e. cell survival fraction) resulting from a mixed n + gamma radiation field with two physical quantities and two biological quantities. The formula is based on a pathway model evolved from that of the compound-dual-radiation-action (CDRA) theory, previously proposed by Rossi and Zaider. The new model employs the recently published data on radiation-induced DNA lesions. The new formula is capable of predicting quantitatively the synergistic effect caused by the interactions between neutron events and gamma ray events, and it is intended to be included into a new dosimetry protocol for future 252Cf brachytherapy.
authors.affiliation: Nuclear & Radiological Engineering Program, Georgia Institute of Technology, Neely Research Center, 900 Atlantic Drive, Atlanta, GA 30332-0425, USA. chris.wang@nre.gatech.edu
authors.forename: C K
authors.initials: CK
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D001822:Body Burden; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D002142:Californium / Q000009:adverse effects / Q000627:therapeutic use*; D002470:Cell Survival / Q000528:radiation effects; D003198:Computer Simulation; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects / Q000627:therapeutic use*; D008954:Models, Biological; D009502:Neutrons / Q000009:adverse effects / Q000627:therapeutic use*; D011835:Radiation Protection / Q000379:methods; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
chemical_list: D004247:DNA; D002142:Californium