Triterpenoid saponin from Viola hondoensis W. Becker et H Boss. and their effect on MMP-1 and type I procollagen expression.
Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-omicron-[omicron-beta-D-glucopyranosyl-(1 --> 2)-omicron-beta-D-glucopyranosyl] oleanolic acid) from the whole plants of Viola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time.
Moon
Hyung-In
HI
Department of Dermatology, Seoul National University College of Medicine, and Clinical research Institute, Seoul National University Hosipital, Seoul 110-744, Korea. himun@skku.edu
Chung
Jin Ho
JH
Lee
Joong-Ku
JK
Zee
Ok-Pyo
OP
D015153:Blotting, Western; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D024042:Collagen Type I / Q000096:biosynthesis*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis*; D010936:Plant Extracts / Q000032:analysis; D012503:Saponins / Q000032:analysis* / Q000494:pharmacology*; D014315:Triterpenes / Q000032:analysis* / Q000494:pharmacology*; D014466:Ultraviolet Rays; D032413:Viola / Q000737:chemistry*
D024042:Collagen Type I; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; D002392:Catechin; C045651:epigallocatechin gallate; D020781:Matrix Metalloproteinase 1