title: Reversible cerebellar lesions induced by metronidazole therapy for helicobacter pylori.
abstract: Metronidazole is widely used for chronic or refractory infection and has recently also been used for the treatment of Helicobacter pylori. The authors report the case of a Japanese patient presenting with reversible cerebellar lesions induced by prolonged administration of metronidazole for treatment of H pylori with magnetic resonance imaging findings. Although rare, prolonged and high-dose administration of metronidazole may induce cerebellar lesions. Increased awareness of this phenomenon is important, as these lesions are reversible with discontinuation of this drug.
authors.affiliation: Division of Neurology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan. sipin@med.toho-u.ac.jp
authors.forename: Hirono
authors.initials: H
authors.lastname: Ito
authors.forename: Michiyuki
authors.initials: M
authors.lastname: Maruyama
authors.forename: Naoko
authors.initials: N
authors.lastname: Ogura
authors.forename: Toshiki
authors.initials: T
authors.lastname: Fujioka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Aikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002526:Cerebellar Diseases / Q000139:chemically induced*; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008279:Magnetic Resonance Imaging; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole