title: Repeatability of noninvasive surrogates of endothelial function.
abstract: We compared the repeatability of 2 ultrasonographic methods for endothelial function assessment at brachial artery-flow-mediated dilation (FMD) and post-ischemic peak blood flow (PBF). Twenty healthy volunteers were examined twice within 10 days; coefficients of variation were 13.8% for PBF and 41.0% for FMD. PBF seems to be superior to FMD in terms of reproducibility. Consequently, smaller noninvasive studies of endothelial function can be designed utilizing PBF compared with FMD.
authors.affiliation: Third Department of Medicine, General University Hospital, Prague, Czech Republic. jmali@lf1.cuni.cz
authors.forename: Jan
authors.initials: J
authors.lastname: Malik
authors.forename: Dan
authors.initials: D
authors.lastname: Wichterle
authors.forename: Tomas
authors.initials: T
authors.lastname: Haas
authors.forename: Vojtech
authors.initials: V
authors.lastname: Melenovsky
authors.forename: Jan
authors.initials: J
authors.lastname: Simek
authors.forename: Tomas
authors.initials: T
authors.lastname: Stulc
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001916:Brachial Artery / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D014463:Ultrasonography / Q000379:methods*; D014664:Vasodilation / Q000502:physiology