Identification of a novel HLA-DPB1 allele--DPB1*0102.
In this report, we describe the identification of a novel HLA-DPB1 allele, DPB1*0102, which was first found in a 27-year-old woman and was later detected again in another person, from the Han population of China. According to the nucleotide alignment, DPB1*0102 was the most similar to DPB1*0202, with only one nucleotide substitution from A to G at position 192 among three closely related alleles--DPB1*0202, DPB1*2401 and DPB1*0501. This substitution was a non-synonymous one, which caused a change of amino acid from E to K at codon 69 of DP beta-chain in the mature protein.
Lv
F
F
Key Laboratory of Genetic Engineer of MOE, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, Guangdong, China.
Lin
J
J
Liu
Z
Z
Gao
J
J
Fu
Y
Y
Xu
A
A
D000328:Adult; D000483:Alleles; D001483:Base Sequence; D002681:China; D017931:DNA Primers / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D017931:DNA Primers; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen