title: Salivary duct carcinoma with neuroendocrine features: report of a case with cytological and immunohistochemical study.
abstract: We report a salivary duct carcinoma (SDC) of parotid gland in a 75-year-old male. Initially, it was studied by fine-needle aspiration, which disclosed features of malignancy consistent with a high-grade carcinoma. Histologically, the tumor showed typical features of SDC, predominantly with a solid and apocrine pattern. The aggressive behavior of this tumor was documented by facial palsy and the presence of 12 regional lymph node metastases. Immunohistochemical study showed positivity for cytokeratins (AE1/AE3), cytokeratin 7, GCDFP-15, C-erbB-2, Mib-1, topoisomerase II alpha, p53, and androgen receptors. Diffuse positivity with chromogranin-A, synaptophysin, and Grimelius stains was also observed, suggesting endocrine features. Phosphotungstic acid hematoxylin, antimitochondrial antigen, progesterone and estrogen receptors, cytokeratin 20, and S-100 stains were negative. To our knowledge, this is the first case reported of SDC exhibiting neuroendocrine differentiation.
authors.affiliation: Department of Pathology, Hospital Marina Alta, 03700 Denia, Alicante, Spain. laforga_jua@gva.es
authors.forename: Juan B
authors.initials: JB
authors.lastname: Laforga
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D010307:Parotid Neoplasms / Q000378:metabolism / Q000473:pathology*