Detection and characterization of betaretroviral sequences, related to sheep Jaagsiekte virus, in Africans from Nigeria and Cameroon.
Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenomatosis (OPA) that resembles bronchioloalveolar carcinoma (BAC) in humans. To test the possible role of JSRV in human diseases, DNA specimens from 103 individuals either healthy or suffering from lung carcinomas were analyzed for JSRV sequences. orf-x sequences were detected in 19 of 64 samples and gag-prt sequences in 4 of 38 samples, predominantly in individuals from Africa. Sequences obtained from orf-x amplimers varied in-between each other and differed from control endogenous ovine JSRV sequence. No association with lung cancer was found. This is the first report of JSRV-like sequences detected in humans.
Morozov
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VA
Paul-Ehrlich-Institut, 63225 Langen, Germany.
Lagaye
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S
Löwer
J
J
Löwer
R
R
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000821:virology*; D000818:Animals; D001483:Base Sequence; D030121:Betaretrovirus / Q000235:genetics*; D002163:Cameroon; D018288:Carcinoma, Small Cell / Q000821:virology; D006801:Humans; D022141:Jaagsiekte sheep retrovirus / Q000235:genetics*; D008175:Lung Neoplasms / Q000821:virology*; D008969:Molecular Sequence Data; D009549:Nigeria; D011648:Pulmonary Adenomatosis, Ovine / Q000821:virology; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012756:Sheep / Q000821:virology*