title: Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice.
abstract: We measured preprocortistatin mRNA expression in young and aged transgenic (Tg) mice overexpressing the human beta-amyloid precursor protein (hbetaAPP) under the platelet-derived growth factor-beta promoter. Our findings suggest that the significant increase in hippocampal cortistatin mRNA expression during normal aging is significantly attenuated in Tg mice at an age known to exhibit beta-amyloid protein (Abeta) deposition. These deficits in cortistatin expression may play a role in the deficits in hippocampal-dependent spatial learning and sleep/wake states previously demonstrated in aged Tg mice.
authors.affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla , CA 92037, USA.
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Winsky-Sommerer
authors.forename: Avron D
authors.initials: AD
authors.lastname: Spier
authors.forename: Véronique
authors.initials: V
authors.lastname: Fabre
authors.forename: Luis
authors.initials: L
authors.lastname: de Lecea
authors.forename: José R
authors.initials: JR
authors.lastname: Criado
mesh_terms: D000375:Aging / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology; D000818:Animals; D015536:Down-Regulation / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008822:Mice, Transgenic; D009479:Neuropeptides / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011498:Protein Precursors / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000096:biosynthesis / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; D009479:Neuropeptides; D011498:Protein Precursors; D012333:RNA, Messenger; C099323:cortistatin; C107518:preprocortistatin; D020797:Receptor, Platelet-Derived Growth Factor beta