title: Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat.
abstract: The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V for 20 min) was applied to bilateral Hoku (LI-4) and Zusanli (ST-36) on 12 hrs and 36 hrs after induction of colitis. EA-treatment significantly reduced the macroscopic damage and the myeloperoxidase activity of colonic samples at 3 days post-induction of colitis. Colitic colon showed a decreased in vitro motility. However, colonic motility of EA-treated group was not significantly different from that of normal group. The anti-inflammatory effect of EA was not inhibited by a glucocorticoid receptor antagonist, RU-486, but suppressed by a beta-adrenoceptor antagonist, propranonol. These results suggest that EA-treatment has a beneficial effect on colitis, and its anti-inflammatory effect is mediated by beta-adrenoceptor activation but not by endogenous glucocorticoiddependent mechanism.
authors.affiliation: Department of Physiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors.forename: Jeoung Woo
authors.initials: JW
authors.lastname: Kang
authors.forename: Tae Wan
authors.initials: TW
authors.lastname: Kim
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: La
authors.forename: Tae Sik
authors.initials: TS
authors.lastname: Sung
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Kwon
authors.forename: Jeum Yong
authors.initials: JY
authors.lastname: Kim
authors.forename: Il Suk
authors.initials: IS
authors.lastname: Yang
mesh_terms: D019342:Acetic Acid; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D003092:Colitis / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000628:therapy*; D015671:Electroacupuncture / Q000662:veterinary*; D004791:Enzyme Inhibitors / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000502:physiology; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D015735:Mifepristone / Q000494:pharmacology; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009195:Peroxidase / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000319:Adrenergic beta-Antagonists; D018679:Cholinergic Agonists; D004791:Enzyme Inhibitors; D006727:Hormone Antagonists; D015735:Mifepristone; D002217:Carbachol; D011433:Propranolol; D009195:Peroxidase; D019342:Acetic Acid; D019331:NG-Nitroarginine Methyl Ester