title: Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis.
abstract: OBJECTIVE
  To study the protective effects of tumor necrosis factor alpha (TNFalpha) antibody on pancreatic encephalopathy in rats.
  
  
  METHODS
  One hundred and twenty SD rats were randomly divided into normal control group, acute necrotizing pancreatitis group and TNFalpha antibody treated group. Acute hemorrhage necrotizing pancreatitis model in rats was induced by retrograde injection of 50 g/L sodium taurocholate into the pancreatobiliary duct. Serum TNFalpha was detected and animals were killed 12 h after drug administration. Changes in content of brain water, MDA and SOD as well as leucocyte adhesion of brain microvessels were measured.
  
  
  RESULTS
  In TNFalpha antibody treated group, serum TNFalpha level was decreased. Content of brain water, MDA and SOD as well as leucocyte adhesion were decreased significantly in comparison with those of acute necrotizing pancreatitis group (P<0.05).
  
  
  CONCLUSIONS
  TNFalpha antibody can alleviate the brain damage of rats with acute hemorrhage necrotizing pancreatitis.
authors.affiliation: Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Yang
authors.forename: Ji-Peng
authors.initials: JP
authors.lastname: Li
authors.forename: Kai-Zong
authors.initials: KZ
authors.lastname: Li
authors.forename: Ke-Feng
authors.initials: KF
authors.lastname: Dou
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D001921:Brain / Q000276:immunology / Q000473:pathology*; D001925:Brain Damage, Chronic / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D007958:Leukocyte Count; D008315:Malondialdehyde / Q000032:analysis; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000139:chemically induced / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000032:analysis; D013656:Taurocholic Acid; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D014867:Water / Q000032:analysis
chemical_list: D000906:Antibodies; D014409:Tumor Necrosis Factor-alpha; D014867:Water; D008315:Malondialdehyde; D013656:Taurocholic Acid; D013482:Superoxide Dismutase