title: Bronchial hyperresponsiveness in children with atopic rhinitis: a 7-year follow-up.
abstract: BACKGROUND
  A high prevalence of bronchial hyperresponsiveness (BHR) was found in atopic subjects with rhinitis. Those subjects may be at higher risk for developing bronchial asthma. We evaluated, in a 7-year follow-up, BHR and atopy in a homogeneous population of nonasthmatic children with allergic rhinitis (AR), and their role in asthma development.
  
  
  METHODS
  Twenty-eight children (6-15 years) with AR were studied. At enrollment (T(0)), skin tests, total serum IgE assay, peak expiratory flow (PEF) monitoring and methacholine (Mch) bronchial challenge were performed. BHR was computed as the Mch dose causing a 20% forced expiratory volume (FEV)(1) fall (PD(20)FEV(1)) and as dose-response slope (D(RS)). Subjects were reassessed after 7 years (T(1)) using the same criteria.
  
  
  RESULTS
  At T(0), 13 children (46%), showing a PD(20)FEV(1) <1526 microg of Mch, had BHR (Mch+), although PEF variability (PEFv) was within normal limits. None of the children with negative methacholine test developed bronchial asthma after 7 years. Of the 13 Mch+, only two reported asthma symptoms after 7 years. No significant change was seen in the other parameters of atopy considered.
  
  
  CONCLUSIONS
  Children with allergic rhinitis present a high prevalence of BHR. Nevertheless, their PEFv is normal and the rate of asthma development low.
authors.affiliation: Istituto di Biomedicina e Immunologia Molecolare del C.N.R., Palermo, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cibella
authors.forename: G
authors.initials: G
authors.lastname: Cuttitta
authors.forename: S
authors.initials: S
authors.lastname: La Grutta
authors.forename: M R
authors.initials: MR
authors.lastname: Hopps
authors.forename: G
authors.initials: G
authors.lastname: Passalacqua
authors.forename: G B
authors.initials: GB
authors.lastname: Pajno
authors.forename: G
authors.initials: G
authors.lastname: Bonsignore
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000209:etiology* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000150:complications / Q000503:physiopathology*; D002648:Child; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000503:physiopathology; D008137:Longitudinal Studies; D008297:Male; D012123:Pulmonary Ventilation; D012220:Rhinitis / Q000150:complications / Q000503:physiopathology*