[Potential influence of nicotine on inflammation and induction of autoantibodies in rats with adjuvant arthritis].
The influence of chronic administration of nicotine diluted in the drinking water on the parameters of systemic inflammation and autoimmune processes in rats (August line) with adjuvant-induced arthritis, were studied. The experiments have shown that nicotine acts as an antiphlogistic means (the amount of C-reactive protein rises in the blood) and activates autoimmune processes: induction of rheumatic factor, of autoantibodies to serotonin, and glial fibrillar acid protein. It was supposed that nicotine has a potential impact on immunocompetent cells.
Melekhov
M G
MG
Ruleva
N Iu
NIu
Liukova
T K
TK
Dugin
C F
CF
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology* / Q000473:pathology; D015551:Autoimmunity / Q000187:drug effects*; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008297:Male; D009538:Nicotine / Q000008:administration & dosage*; D018722:Nicotinic Agonists / Q000008:administration & dosage*; D051381:Rats; D012217:Rheumatoid Factor / Q000276:immunology*; D012701:Serotonin / Q000276:immunology
D005904:Glial Fibrillary Acidic Protein; D018722:Nicotinic Agonists; D012701:Serotonin; D009538:Nicotine; D012217:Rheumatoid Factor