Dictyosphaeric acids A and B: new decalactones from an undescribed Penicillium sp. obtained from the alga Dictyosphaeria versluyii.
Fungal isolate F01V25 was obtained from the alga Dictyosphaeria versluyii collected near Dravuni, Fiji, in 2001 and represented a previously undescribed Penicillium sp. Fermentation of isolate F01V25 resulted in the production of two new polyketides, dictyosphaeric acids A and B, along with the known anthraquinone carviolin. The relative stereochemistry of dictyosphaeric acids A and B was determined using the J-based configuration analysis method in conjunction with ROE and NOE correlations.
Bugni
Tim S
TS
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Janso
Jeffrey E
JE
Williamson
R Thomas
RT
Feng
Xidong
X
Bernan
Valerie S
VS
Greenstein
Michael
M
Carter
Guy T
GT
Maiese
William M
WM
Ireland
Chris M
CM
D056890:Eukaryota; D005367:Fiji; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*
D007783:Lactones; C491891:dictyosphaeric acid A; C491892:dictyosphaeric acid B