title: Comparing some operational approaches to the limit of detection.
abstract: The limit of detection is one of the fundamental metrological characteristics of any chemical measurement systems but, even now, it is a highly controversial matter because of the existing differences in terminology, formulations and understanding. Even when limiting the analysis to those operational approaches that, because of their simplicity, are often suggested by the guidelines of some international bodies, the available approaches can return appreciably different estimates. In this paper, the matter is critically reconsidered, and the different approaches compared with the aid of some case studies.
authors.affiliation: Di.Pro.Ve., Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy. elio.desimoni@unimi.it
authors.forename: Elio
authors.initials: E
authors.lastname: Desimoni
authors.forename: Barbara
authors.initials: B
authors.lastname: Brunetti
authors.forename: Raffaella
authors.initials: R
authors.lastname: Cattaneo
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods* / Q000592:standards; D004563:Electrochemistry / Q000379:methods; D009573:Nitrites / Q000032:analysis; D010984:Platinum / Q000032:analysis; D012107:Research Design; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods
chemical_list: D009573:Nitrites; D010984:Platinum