title: Effects of alcohol consumption on osseointegration of titanium implants in rabbits.
abstract: Alcohol consumption affects bone metabolism by impairing osteoblast proliferation and by increasing osteoclastic activity. The purpose of this study was to evaluate bone formation in alcohol-fed rabbits following the insertion of dental titanium implants. Animals were fed with 20% ethanol sugarcane brandy pre- and postoperatively (group 1), preoperatively only (group 2), and with water as control (group 3). During the postoperative period, rabbits received doses of polyfluorochrome labels (i.e., alizarin, calcein, and tetracycline). Rabbits were killed 8 weeks after the implant insertion. The polyfluorochrome-labeled bone areas in rabbits with alcohol consumption in pre- and postoperative (group 1) and preoperatively only (group 2) were significantly less (P <.05) than in the control group (group 3). The percentage of direct bone-to-implant contact was significantly less in pre- and postoperative (49.5%) and preoperative-only (49.2%) groups than in the control group (64.7%) (P <.05). Alcoholic rabbits demonstrated significantly less bone density and direct bone-to-implant contact.
authors.affiliation: Laboratory of Implantology, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. samuelkoo@yahoo.com
authors.forename: Samuel
authors.initials: S
authors.lastname: Koo
authors.forename: Bruno
authors.initials: B
authors.lastname: König
authors.forename: Cristina Ioshie
authors.initials: CI
authors.lastname: Mizusaki
authors.forename: Sérgio
authors.initials: S
authors.lastname: Allegrini
authors.forename: Marcelo
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: Marcelo José
authors.initials: MJ
authors.lastname: Carbonari
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D015921:Dental Implants; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D020007:Implants, Experimental; D016348:Osseointegration / Q000187:drug effects*; D011817:Rabbits; D013977:Tibia
chemical_list: D015921:Dental Implants; D000431:Ethanol