Physical characteristics of polymer complexes in suspension obtained from cellulosic latexes with ondansetron.
Ondansetron is a carbazol with antiemetic properties. It is used primarily to control nausea and vomiting caused by cytotoxic chemotherapy and radiotherapy, as well as in postoperative vomiting in gynecological surgery. Ondansetron has a half-life of approximately 4 h, hence it is a matter of great interest to determine the ideal conditions for the formation of a drug-polymer complex in order to prolong the duration of the therapeutic action. A stability study of the active drug was first carried out on each of the polymers (Aquateric and Aquacoat). The adsorption of ondansetron on the lattices was determined with respect to time, pH and concentration. The results obtained suggest that both polymers are suitable as drug carriers for the controlled-release formulations obtained. We conclude that an acid pH is evidently fundamental in the adsorption process of this drug in the latexes. Moreover, the Aquateric latex would seem to be the best-suited polymer to use as a vehicle for drug delivery.
Ruiz
A
A
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, E-18071 Granada, Spain. adolfina@ugr.es
Llácer
J M
JM
Morales
E
E
Gallardo
V
V
D000327:Adsorption; D000932:Antiemetics / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D045424:Complex Mixtures / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004355:Drug Stability; D005427:Flocculation; D006863:Hydrogen-Ion Concentration; D007840:Latex / Q000737:chemistry; D008422:Materials Testing; D017294:Ondansetron / Q000008:administration & dosage / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D013535:Suspensions / Q000737:chemistry
D000932:Antiemetics; D001672:Biocompatible Materials; D045424:Complex Mixtures; D003692:Delayed-Action Preparations; D007840:Latex; D014677:Pharmaceutical Vehicles; D011108:Polymers; D011134:Polysaccharides; D013535:Suspensions; C059120:Aquateric; D017294:Ondansetron; C013517:ethyl cellulose; D002482:Cellulose