title: New DNA binding ligands as a model of chromomycin A3.
abstract: Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this study, new DNA-binding ligands were designed to mimic Chromomycin A(3) (CRA(3)), which contains a hydroxylated tetrahydroanthracene chromophore substituted with di and trisaccharides. The trisaccharide part of CRA(3) that is supposed to contribute to form the Mg(2+)-coordinated dimer was expected to be mimicked by a simple alkyl group attached to the chromophore part as new model compounds. The present study has successfully demonstrated that the new ligands form Mg(2+)-coordinated dimer complexes to exhibit DNA-binding affinity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Imoto
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Haruta
authors.forename: Kyouichi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D014128:Chromomycin A3 / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D019281:Dimerization; D008024:Ligands; D008274:Magnesium / Q000378:metabolism
chemical_list: D008024:Ligands; D004247:DNA; D014128:Chromomycin A3; D008274:Magnesium