Axoval neuropathy as initial manifestation of primary amyloidosis: report of a case submitted to bone marrow transplantation.
Amyloidosis is a syndrome characterized by deposition of a highly insoluble protein material in the extracellular space that may affect several organs. It may be generalized and idiopathic (primary amyloidosis). We describe the case of a 48 years-old woman with axonal neuropathy associated with proteinuria, whose final investigation resulted in diagnosis of primary amyloidosis (AL). She was submitted to autologous bone marrow transplantation. We discuss some aspects related to diagnosis of neuropathy and current treatment of AL.
Barsottini
Orlando G Povoas
OG
Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa Albert Einstein, São Paulo, SP, Brazil. orlandobarsottini@hotmail.com
Arantes
Adriano
A
Sigulem
Daniel
D
Kutner
José Mauro
JM
Ribeiro
Andreza Alice Feitosa
AA
Moura
Luiz A
LA
Hamerschlak
Nelson
N
D017772:Amyloid Neuropathies / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D016026:Bone Marrow Transplantation; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008875:Middle Aged