title: Usefulness of rh-G-CSF in early-onset severe neutropenia in neonatal lupus syndrome.
abstract: Neutropenia is a mild and transient manifestation of neonatal lupus syndrome (NLS) in the second or third month of life. The authors describe a newborn with an early-onset severe neutropenia due to anti-Ro/SSA. In the second day of life, neutropenia has been treated with recombinant human granulocyte colony-stimulating factor (rh-G-CSF). This is the first case in which rh-G-CSF was used in NLS, and the authors studied the pharmacologic action of the drug in relationship to the pathophysiology of NLS.
authors.affiliation: Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy. zuppaaa@rm.unicatt.it
authors.forename: Antonio Alberto
authors.initials: AA
authors.lastname: Zuppa
authors.forename: Daniele
authors.initials: D
authors.lastname: De Luca
authors.forename: Pierluigi
authors.initials: P
authors.lastname: De Turris
authors.forename: Francesco
authors.initials: F
authors.lastname: Cota
authors.forename: Guiseppe
authors.initials: G
authors.lastname: Tortorolo
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D011994:Recombinant Proteins
chemical_list: D000974:Antibodies, Antinuclear; D011994:Recombinant Proteins; C035356:SS-A antibodies; D016179:Granulocyte Colony-Stimulating Factor