Pulmonary function in uremic patients on long-term hemodialysis.
Twenty patients with end-stage renal failure who were on maintenance hemodialysis (HD) underwent pulmonary function testing (PFT) before and shortly after an HD session. On pre-HD PFT, the mean values of all parameters except residual volume (RV) were in the normal range. Mean RV was high (152.9%), and mean diffusing capacity of the lung for carbon monoxide (DLCO) was high-normal (110.4%). The pre-HD static inspiratory (PImax) and expiratory pressures (PEmax) were much lower than normal (67.4% and 36.3%, respectively). After the HD session, repeat PFT revealed a small increase in expiratory flow rates, and a significant drop in PImax. There was a strong correlation between PImax and PEmax (r=0.567, p<0.01) at the pre- and post-HD stages, indicating that common mechanism(s) are responsible for impairment of both inspiratory and expiratory muscle strength. The well-preserved DLCO was thought to be due to the use of biocompatible dialyzer membranes. Chronic vascular congestion might be the other explanation of high DLCO.
Karacan
Ozgür
O
Department of Pulmonary Diseases, Başkent University Hospital, Ankara, Turkey. ozgurkaracan@yahoo.com
Tutal
Emre
E
Uyar
Murathan
M
Eyüboğlu
Füsun Oner
FO
Sezer
Siren
S
Ozdemir
F Nurhan
FN
D000328:Adult; D001672:Biocompatible Materials; D005260:Female; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D008567:Membranes, Artificial; D006435:Renal Dialysis; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000502:physiology*; D013997:Time Factors; D014511:Uremia / Q000503:physiopathology / Q000628:therapy*
D001672:Biocompatible Materials; D008567:Membranes, Artificial