title: Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia.
abstract: OBJECTIVE
  We report the immunopathology of progressive subretinal fibrosis, a variant of sympathetic ophthalmia.
  
  
  METHODS
  Brief case report.
  
  
  METHODS
  Review of medical record and immunopathology of a chorioretinal biopsy of a 40-year-old man who presented with left total retinal detachment (RD) following multiple vitrectomies in the right eye for RD. Small peripherally retinal holes, snow banks, and inflammatory nodules along the ora serrata were observed during left vitrectomy. Both eyes deteriorated rapidly to blindness with progressive subretinal fibrosis and inflammation over 3 months, and the patient was unresponsive to systemic prednisolone and azathioprine.
  
  
  RESULTS
  Immunopathology of the chorioretinal biopsy of the right eye revealed aggregates of CD20+ B cells, surrounded by CD3+ T cells. CD68+ macrophages were scattered throughout.
  
  
  CONCLUSIONS
  The rapid clinical course described in this case may be related to the unique immunopathology of rapidly forming peudogerminal centers in the choroids and retina.
authors.affiliation: Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751.
authors.forename: Wee-Kiak
authors.initials: WK
authors.lastname: Lim
authors.forename: Soon-Phaik
authors.initials: SP
authors.lastname: Chee
authors.forename: Ivy
authors.initials: I
authors.lastname: Sng
authors.forename: Robert Burton
authors.initials: RB
authors.lastname: Nussenblatt
authors.forename: Chi-Chao
authors.initials: CC
authors.lastname: Chan
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D001766:Blindness / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008297:Male; D009879:Ophthalmia, Sympathetic / Q000276:immunology* / Q000473:pathology*; D012160:Retina / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D015703:Antigens, CD