[The antioxidant activity of S-(4-quinazolyl)mercaptoacetic acid benzylidene hydrazides in vitro in the "nitrosation stress" model].
The "nitrozation stress" causes modification of the antioxidant enzymes leading to a decrease in their activity. A decrease in this activity and the resulting increase in the production of OH* and NO2* radicals via ONOO* decomposition leads to a significant increase in the extent of free-radical peroxidation during the "nitrozation stress". These factors are unfavorable from the standpoint of oxidative phosphorylation, which is manifested by inhibited activity of the oxidative enzymes. S-(4-Quinazolyl)mercaptoacetic acid benzylidene hydrazides exhibit a high antiradical activity related to the presence of a mercapto group in the quinazoline fragment. The activity depends on the position of this group on and the number of substituents in the benzylidene fragment. The compounds studied reduce the extent of damage in the brain homogenates of rats under conditions of nitrozation stress. This is manifested by inhibition of the free-radical peroxidation and an increase in the activity of antioxidant and prooxidant enzymes.
Dunaev
V V
VV
Belenichev
I F
IF
Kovalenko
S I
SI
Karpenko
A V
AV
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D003198:Computer Simulation; D005609:Free Radicals; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D030421:Peroxynitrous Acid / Q000378:metabolism*; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013864:Thioglycolates / Q000737:chemistry / Q000494:pharmacology*
D000975:Antioxidants; D005609:Free Radicals; D011799:Quinazolines; D013864:Thioglycolates; D030421:Peroxynitrous Acid