title: Isoprenoids of the soft coral Sarcophyton glaucum: Nyalolide, a new biscembranoid, and other terpenoids.
abstract: The chemical content of Sarcophyton glaucum, one of the more abundant soft corals on many coral reefs, collected from many seas, was thoroughly explored, resulting in the discovery of a large number of cembranoids, biscembranoids, sterols, and other secondary metabolites. The presently investigated Kenyan specimens of S. glaucum yielded three new metabolites, i.e., nyalolide (15), a biscembranoid, 16-oxosarcoglaucol acetate (16), a cembranoid, and the sesquiterpene guaiacophine (17). Nyalolide was also isolated from the Kenyan soft coral Sarcophyton elegans. The structures of the new compounds were elucidated by interpretation of their MS and 1D and 2D NMR experiments and, in the case of nyalolide, possessing 11 chiral centers, secured by X-ray diffraction analysis.
authors.affiliation: School of Chemistry and Department of Zoology, Tel-Aviv University, Ramat Aviv 69978, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Feller
authors.forename: Amira
authors.initials: A
authors.lastname: Rudi
authors.forename: Nelly
authors.initials: N
authors.lastname: Berer
authors.forename: Israel
authors.initials: I
authors.lastname: Goldberg
authors.forename: Zafra
authors.initials: Z
authors.lastname: Stein
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Benayahu
authors.forename: Michael
authors.initials: M
authors.lastname: Schleyer
authors.forename: Yoel
authors.initials: Y
authors.lastname: Kashman
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006801:Humans; D007630:Kenya; D007941:Leukemia P388; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes; C492401:nyalolide