title: [Analysis of the relative etiology of non-obstructive azoospermia].
abstract: OBJECTIVE
  To investigate the levels and changes of sexual hormone in serum and seminal plasma, and the epidermal growth factor (EGF), alpha-glucosidase, and fructose in the seminal plasma of non-obstructive azoospermic patients, and to assess the significance of the analysis of their chromosomes.
  
  
  METHODS
  Thirty-six non-obstructive azoospermic males and 26 normal males were chosen. The results in reproductive endocrine and genetics obtained by radioimmunoassay, colorimetry, and chromosomes G and C banding assay were compared and analyzed to explore into the causes of infertility.
  
  
  RESULTS
  The levels of FSH, LH, PRL and E2 in the serum of the non-obstructive azoospermic patients were higher than those of the control group, but the T level had no significant difference between the two groups. There were no obvious differences in the sexual hormones except in FSH of the seminal plasma. There were 2 cases of abnormal sex chromosomes, 2 cases of big Y chromosomes and 7 cases of small Y chromosomes in the non-obstructive azoospermic patients. No correlation was found between EGF and fructose in the seminal plasma.
  
  
  CONCLUSIONS
  The level of sexual hormone in serum, alpha-glucosidase in seminal plasma and abnormal chromosomes might be closely related to non-obstructive azoospermia.
authors.affiliation: Department of Obstetrics & Gynecology, the First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830054, China. duan605@eyou.com
authors.forename: Ling
authors.initials: L
authors.lastname: Duan
authors.forename: Xiding
authors.initials: X
authors.lastname: Er
authors.forename: Jinping
authors.initials: J
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Duan
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.forename: Ruijun
authors.initials: R
authors.lastname: Liu
authors.forename: Chengjun
authors.initials: C
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Du
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D002871:Chromosome Banding; D041322:Chromosomes, Human, Y; D004815:Epidermal Growth Factor / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D012661:Semen / Q000737:chemistry; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D012739:Gonadal Steroid Hormones; D004815:Epidermal Growth Factor; D000520:alpha-Glucosidases