title: Estimation of the Hemodynamic Response Function in event-related functional MRI: directed acyclic graphs for a general Bayesian inference framework.
abstract: A convenient way to analyze BOLD fMRI data consists of modeling the whole brain as a stationary, linear system characterized by its transfer function: the Hemodynamic Response Function (HRF). HRF estimation, though of the greatest interest, is still under investigation, for the problem is ill-conditioned. In this paper, we recall the most general Bayesian model for HRF estimation and show how it can beneficially be translated in terms of graphical models, leading to (i) a clear and efficient representation of all structural and functional relationships entailed by the model, and (ii) a straightforward numerical scheme to approximate the joint posterior distribution, allowing for estimation of the HRF, as well as all other model parameters. We finally apply this novel technique on both simulations and real data.
authors.affiliation: INSERM U494. marrelec@imed.jussieu.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Marrelec
authors.forename: Philippe
authors.initials: P
authors.lastname: Ciuciu
authors.forename: Mélanie
authors.initials: M
authors.lastname: Pélégrini-Issac
authors.forename: Habib
authors.initials: H
authors.lastname: Benali
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001499:Bayes Theorem; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D016000:Cluster Analysis; D003198:Computer Simulation; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008955:Models, Cardiovascular; D015233:Models, Statistical; D010363:Pattern Recognition, Automated; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D013382:Subtraction Technique