title: Sesquiterpene esters from the fruits of Celastrus orbiculatus.
abstract: Three new beta-dihydroagarofuran sesquiterpene esters, 6 alpha-acetoxy-9 beta-benzoyloxy-1 beta-cinnamoyloxy-8 beta-butanoyloxy-beta-dihydroagarofuran (1), 6 alpha-acetoxy-9 beta-benzoyloxy-1 beta-cinnamoyloxy-8 beta-(2-methylbutanoyloxy)-beta-dihydroagarofuran (2), and 6 alpha-acetoxy-1 beta,8 beta-dibenzoyloxy-9 beta-hydroxy-beta-dihydroagarofuran (6), together with three known compounds (3-5) were isolated from the fruits of Celastrus orbiculatus THUNB. Their structures were elucidated on the basis of spectroscopic methods. Compound 4 showed moderate activity in inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells with an IC(50) value of 43.7 microM.
authors.affiliation: Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China.
authors.forename: Yuan Qiang
authors.initials: YQ
authors.lastname: Guo
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Da Li
authors.initials: DL
authors.lastname: Meng
authors.forename: Jin Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000818:Animals; D031247:Celastrus / Q000737:chemistry*; D002460:Cell Line; D005638:Fruit / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide