title: Donor age influences 10-year liver graft histology independently of hepatitis C virus infection.
abstract: OBJECTIVE
  Factors influencing the long-term histological outcome of liver graft are not known. We conducted a prospective study based on a 10-year liver biopsy in order to identify the main factors influencing long-term graft histology.
  
  
  METHODS
  270 of 423 patients who still had their first functional graft 10 years after liver transplantation accepted to undergo routine liver biopsy. All slides were blindly reviewed by two pathologists.
  
  
  RESULTS
  Main histological findings were fibrosis in 143 patients (54%) and ductopenia in 76 patients (29%). Ductopenia was independently related to higher donor age (32+/-12 vs 28+/-13 years; P<0.02). Severity of fibrosis was influenced by hepatitis C virus (HCV) infection (P<0.001), hepatitis B virus (HBV) recurrence (P=0.001) and higher donor age (P=0.03). Eighty biopsies (30%) showed minimal-change lesions which were associated with the absence of HCV infection (24/80 vs 99/185; P<0.001) or of HBV infection (1/80 vs 15/185; P=0.03) and lower donor age (25+/-11 vs 31+/-13 years; P<0.001).
  
  
  CONCLUSIONS
  Post-transplant infection by HCV or HBV are main factors influencing the histological course of liver graft. Donor age was also a strong factor in HCV infected patients as well as in HCV-negative patients. This variable should be taken into account, particularly for candidate recipients with long life expectancy.
authors.affiliation: Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12-14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France.
authors.forename: Kinan
authors.initials: K
authors.lastname: Rifai
authors.forename: Mylène
authors.initials: M
authors.lastname: Sebagh
authors.forename: Vincent
authors.initials: V
authors.lastname: Karam
authors.forename: Faouzi
authors.initials: F
authors.lastname: Saliba
authors.forename: Daniel
authors.initials: D
authors.lastname: Azoulay
authors.forename: René
authors.initials: R
authors.lastname: Adam
authors.forename: Denis
authors.initials: D
authors.lastname: Castaing
authors.forename: Henri
authors.initials: H
authors.lastname: Bismuth
authors.forename: Michel
authors.initials: M
authors.lastname: Reynès
authors.forename: Didier
authors.initials: D
authors.lastname: Samuel
authors.forename: Cyrille
authors.initials: C
authors.lastname: Féray
mesh_terms: D000328:Adult; D000367:Age Factors; D001706:Biopsy; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000601:surgery*; D016031:Liver Transplantation / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D014019:Tissue Donors