[Neurocutaneous melanosis and malignant melanoma].
A 36-year-old man presented with a giant congenital melanocytic nevus and multiple disseminated melanocytic nevi. After he had developed neurological symptoms (grand mal seizures), a cerebral metastasis of a malignant melanoma without a primary melanoma was found. The patient was diagnosed as having a neurocutaneous melanosis with a cerebral metastasis. In spite of a variety of therapeutic attempts (surgery, radiation therapy and chemotherapy) he followed a rapidly progressive, lethal course with increased intracranial pressure, hydrocephalus and spinal metastases.
Tartler
U
U
Hautklinik der Heinrich Heine-Universität, Düsseldorf.
Mang
R
R
Schulte
K W
KW
Hengge
U
U
Megahed
M
M
Reifenberger
J
J
D000328:Adult; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary / Q000628:therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy; D008548:Melanosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D020752:Neurocutaneous Syndromes / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009508:Nevus, Pigmented / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary / Q000628:therapy