title: Renovascular hypertension due to antithrombin deficiency in childhood.
abstract: Inherited antithrombin deficiency generally causes a predisposition toward vascular thrombus above the age of 15 years. A 1-year-old boy developed renal hypertension caused by renal artery obstruction due to thrombus formation. This thrombus formation was attributed to antithrombin deficiency caused by a novel SERPINCI gene mutation (AT III Akita, M352R). This suggests that antithrombin deficiency can cause renal artery obstruction, inducing renal hypertension through vascular thrombosis even in children.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Miura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Ikuko
authors.initials: I
authors.lastname: Takahashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Komatsu
authors.forename: Satoko
authors.initials: S
authors.lastname: Tsuchida
authors.forename: Tamaki
authors.initials: T
authors.lastname: Mikami
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Goro
authors.initials: G
authors.lastname: Takada
mesh_terms: D020152:Antithrombin III Deficiency / Q000150:complications* / Q000235:genetics*; D006801:Humans; D006978:Hypertension, Renovascular / Q000235:genetics*; D007223:Infant; D008297:Male; D009154:Mutation; D012078:Renal Artery Obstruction / Q000209:etiology* / Q000235:genetics; D015843:Serpins / Q000235:genetics; D013927:Thrombosis / Q000235:genetics*
chemical_list: D015843:Serpins