[Effects of dexamethasone on mucin gene expression in human nasal polyps].
OBJECTIVE
To clarify whether glucocorticoid influences mucin 8 gene expression in human nasal polyps.


METHODS
Thirty patients were randomly divided into two groups. The first group were given dexamethasone intravenously before surgery. We make sure the second group of patients didn't receive any kind of glucocorticoid therapy during thirty days before surgery. MUC8 MRNA expression in nasal polyps of each group was detected by reverse transcription polymerase chain reaction (RT-PCR).


RESULTS
The MUC8 MRNA expression in the first group (0.71 +/- 0.34) was lower than that of the second group (1.12 +/- -0.26).


CONCLUSIONS
DXM supress MUC8 MRNA expression in nasal polyps and this result provide another aspect for glucocorticoid's antiinflammatory mechanism.
Wang
Jiyun
J
Department of Otorhinolaryngology, Second Affiliated Hospital, Zhejiang University, Hang-zhou, 310009, China.
Yang
Beibei
B
D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000096:biosynthesis* / Q000235:genetics; D009298:Nasal Polyps / Q000188:drug therapy* / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis
D000893:Anti-Inflammatory Agents; C105059:MUC8 protein, human; D009077:Mucins; D012333:RNA, Messenger; D003907:Dexamethasone