title: [Studies on chiral inversion of dextropantoprazole in human].
abstract: OBJECTIVE
  To study the chiral inversion of dextropantoprazole in human.
  
  
  METHODS
  Three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazole. An HPLC method was developed and used to determine the total plasma concentrations of each enantiomer. The ratios of the enantiomers in plasma samples were measured on a Chiral-AGP column. The plasma concentration of each enantiomer was then calculated using the ratios of enantiomers and total concentrations of the two enantiomers previously measured.
  
  
  RESULTS
  The AUC0-t of levopantoprazole was only 1.5% of the total AUC0-t of enantiomers.
  
  
  CONCLUSIONS
  The chiral inversion from dextropantoprazole to levopantoprazole does not occur in the three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazol.
authors.affiliation: Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Xie
authors.forename: Bing-hua
authors.initials: BH
authors.lastname: Yang
authors.forename: Yi-fan
authors.initials: YF
authors.lastname: Zhang
authors.forename: Da-fang
authors.initials: DF
authors.lastname: Zhong
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000284:Administration, Oral; D000328:Adult; D000897:Anti-Ulcer Agents / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D019540:Area Under Curve; D001562:Benzimidazoles / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D000077402:Pantoprazole; D013237:Stereoisomerism; D013454:Sulfoxides / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D013454:Sulfoxides; D000077402:Pantoprazole; D009853:Omeprazole