[Study on tumor cells' multidrug resistance and its reversion by Chinese herbs].
Multidrug resistance (MDR) is an important biological behavior of tumor cells in chemotherapy. And it is also one of the major causes of clinical chemotherapy failure. According to the literature at home and abroad, and combining with the results of authors' investigations, this paper mainly discusses the mechanism of tumor cells' MDR and its reversion by Chinese herbs.
Chen
Xin-Yi
XY
Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100700, China. chenxinyi0729@sohu.com
Liu
Jiang-Tao
JT
D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011493:Protein Kinase C / Q000378:metabolism; D020394:Vault Ribonucleoprotein Particles / Q000378:metabolism; D000099187:Major Vault Protein
D004365:Drugs, Chinese Herbal; D005978:Glutathione; D006023:Glycoproteins; D009363:Neoplasm Proteins; D011493:Protein Kinase C; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein