title: Imiquimod 5 percent cream and the treatment of cutaneous malignancy.
abstract: Imiquimod is a novel synthetic compound that is a member of the imidazoquinolone family of drugs. This class of drugs, which also includes a more potent member, resimiquimod (R-848), is unique having the properties of topical immune response modifiers and stimulators. Imiquimod resembles a nucleoside analogue and is known for its potent induction of endogenous antiviral pro-inflammatory mediators. This article is a review of the relevant literature as it relates to the off-label applications of imiquimod 5 percent cream for treatment of cutaneous preneoplastic and neoplastic conditions including its recently approved indication for treating actinic keratoses.
authors.affiliation: School of Medicine, University of California Davis, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Navi
authors.forename: Arthur
authors.initials: A
authors.lastname: Huntley
mesh_terms: D000634:Aminoquinolines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001913:Bowen's Disease / Q000188:drug therapy; D002280:Basal Cell Carcinoma / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D045744:Cell Line, Tumor / Q000187:drug effects; D002986:Clinical Trials as Topic; D003218:Condylomata Acuminata / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000188:drug therapy; D000077271:Imiquimod; D007111:Immunity, Cellular / Q000187:drug effects; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D007636:Keratoacanthoma / Q000188:drug therapy; D007642:Keratosis / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary; D015337:Multicenter Studies as Topic; D009182:Mycosis Fungoides / Q000188:drug therapy; D009824:Ointments; D010145:Paget Disease, Extramammary / Q000188:drug therapy; D011230:Precancerous Conditions / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D007155:Immunologic Factors; D009824:Ointments; D000077271:Imiquimod