Age-specific immune response to HspA in Helicobacter pylori-positive persons in Mexico.
The immune response to heat shock protein A (HspA) in Helicobacter pylori-positive adults increases with age in developed countries. This response has not been studied with children or in developing countries (G. I. Pérez-Pérez, J. M. Thiberge, A. Labigne, and M. J. Blaser, J. Infect. Dis. 174:1046-1050, 1996). As determined by using a specific enzyme-linked immunosorbent assay, HspA seropositivity among 592 individuals in Mexico was <10% in children and increased to >40% in adults.
Eamranond
Peter P
PP
Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Torres
Javier
J
Muñoz
Onofre
O
Pérez-Pérez
Guillermo I
GI
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000917:Antibody Formation; D001426:Bacterial Proteins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006360:Heat-Shock Proteins / Q000276:immunology*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D016480:Helicobacter pylori; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016555:Matched-Pair Analysis; D008800:Mexico; D008875:Middle Aged; D012698:Serologic Tests
D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; C113725:HspA protein, bacteria