[Anticholinergic Effect of a New Antiarrhythmic Class III Drug RG-2].
In experiments on isolated rat and rabbit right atrium, a new class III antiarrhythmic drug RG-2 (0,01-1 microM) was shown to have anticholinergic action competing with 0.2-1 mM carbachol. RG-2 (0.1-1 microM) produced dose-dependent increase of APD90% in rat and rabbit atrial cells and had no effects on other action potential parameters. In presence of carbachol RG-2 produced significantly greater increase of APD90% and caused significant increase of APD50%. Thus RG-2 exerts anticholinergic action, which can take important part in RG-2 antiarrhythmic activity.
Fedorov
V V
VV
Cardiology Research Complex; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.
Ivanova
I A
IA
Glukhov
A V
AV
Reznik
A V
AV
Rozenshtraukh
L V
LV
Golitsyn
S P
SP
Ruda
M Ia
MIa
Chazov
E I
EI
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D018680:Cholinergic Antagonists; D006325:Heart Atria / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D018680:Cholinergic Antagonists