Antifungal limonoids from the fruits of Khaya senegalensis.
Investigation of the fruits of Khaya senegalensis resulted in the isolation of three new mexicanolide limonoids containing a rare conjugated diene lactone system named seneganolide A (1), 2-hydroxyseneganolide A (2) and 2-acetoxyseneganolide A (3). Two known limonoids, 3-deacetyl-7-deacetoxy-7-oxokhivorin (4) and methyl 6-hydroxyangolensate (5), were also found. The structures of the new compounds were elucidated on the basis of spectral methods. The antifungal activity of compounds 1, 3 and 5 was tested against the fungus Botrytis cinerea.
Abdelgaleil
Samir A M
SA
Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University, Alexandria, Egypt. samir@chem.agri.kagoshima-u.ac.jp
Iwagawa
Tetsuo
T
Doe
Matsumi
M
Nakatani
Munehiro
M
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020171:Botrytis / Q000187:drug effects*; D005638:Fruit; D006801:Humans; D036701:Limonins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D029582:Meliaceae; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000935:Antifungal Agents; D036701:Limonins; D010936:Plant Extracts