title: Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions.
abstract: It is important to understand which molecules are relevant for linking innate and adaptive immune cells. In this study, we show that OX40 ligand is selectively induced on IL-2, IL-12, or IL-15-activated human NK cells following stimulation through NKG2D, the low affinity receptor for IgG (CD16) or killer cell Ig-like receptor 2DS2. CD16-activated NK cells costimulate TCR-induced proliferation, and IFN-gamma produced by autologous CD4+ T cells and this process is dependent upon expression of OX40 ligand and B7 by the activated NK cells. These findings suggest a novel and unexpected link between the natural and specific immune responses, providing direct evidence for cross-talk between human CD4+ T cells and NK receptor-activated NK cells.
authors.affiliation: Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zingoni
authors.forename: Thierry
authors.initials: T
authors.lastname: Sornasse
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Cocks
authors.forename: Yuetsu
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Angela
authors.initials: A
authors.lastname: Santoni
authors.forename: Lewis L
authors.initials: LL
authors.lastname: Lanier
mesh_terms: D015703:Antigens, CD / Q000502:physiology; D000954:Antigens, Surface; D018122:B7-1 Antigen / Q000378:metabolism / Q000502:physiology*; D051940:B7-2 Antigen; D018106:CD28 Antigens / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002450:Cell Communication / Q000276:immunology*; D002455:Cell Division / Q000276:immunology; D045744:Cell Line, Tumor; D016207:Cytokines / Q000097:blood / Q000502:physiology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000502:physiology; D008565:Membrane Proteins; D020411:Oligonucleotide Array Sequence Analysis; D020239:Receptor Cross-Talk / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D011971:Receptors, Immunologic / Q000097:blood / Q000502:physiology; D054340:Receptors, KIR; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D015854:Up-Regulation / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000954:Antigens, Surface; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D018106:CD28 Antigens; C497964:CD86 protein, human; D016207:Cytokines; D008024:Ligands; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; C505716:TNFRSF4 protein, human; D014409:Tumor Necrosis Factor-alpha