[The dynamics of leukocyte adhesion to the endothelium pial venules under massive blood loss].
The dynamics of leukocytes adhesion to brain microvenules endothelium of Wistar rats were studied under acute massive blood loss. Using the method of vital videomicroscope study of the influence of the influence of the blood volume reduction on the leukocyte-endothelium interaction is investigated. We studied vessels of the diameter under 30 mcm. It is shown that under progressing reduction of the system arterial pressure under 60 mm Hg, the number of leukocytes adhesion to venules' wall reached 20 +/- 3 on 100 mcm, but in terminal stage such acts are the greatest. It is supposed that as a result massive blood loss leukocytes turn out to be the direct reason of the deep pathological disturbances of microcirculation in the brain.
Mel'nikova
N N
NN
Petrova
L A
LA
Fedorova
T E
TE
D000818:Animals; D001921:Brain / Q000098:blood supply*; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012771:Shock, Hemorrhagic / Q000473:pathology; D014699:Venules