title: Quantitative rates of in vivo bone generation for Bioglass and hydroxyapatite particles as bone graft substitute.
abstract: Rates of in vivo bone generation were characterized by point-counting analysis of particulate Bioglass and synthetic hydroxyapatite (HA) in rabbit femora. New bony tissue was observed in approximately 20% of the image area around Bioglass particles at 1 wk, and the degree of trabecular bone growth increased with time. The interparticle space of Bioglass was filled by 80% bonding bone between 6 and 12 wk. The rate constants of trabecular bone growth in the presence of Bioglass were approximately 10.9x10(-3) d(-1) at the periphery of the implantation site. HA particles led to smaller rate constants of approximately 4.6x10(-3) d(-1) at the periphery, and the HA particles developed very small amounts of bridging bone. The quantitative rate of bone growth matched well with previously measured bioactive indices of the materials.
authors.affiliation: Department of Materials, Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujishiro
authors.forename: L L
authors.initials: LL
authors.lastname: Hench
authors.forename: H
authors.initials: H
authors.lastname: Oonishi