title: [Compatibility research of self-designed scaffold biomaterials of nature extracellular matrix].
abstract: OBJECTIVE
  Scaffold biomaterials for cell culture of tissue-engineering demand satisfactory biocompatibility. This experiment aimed to evaluate biocompatibility of self-designed scaffold biomaterial of NECM.
  
  
  METHODS
  The biocompatibility of self-designed NECM was evaluated both in vivo and in vitro, including cytotoxic test, acute and subacute systemic toxicity test, hemolysis test, pyrogenic test, lymphocyte transformation test and long-term subcutaneous implantation test of NECM.
  
  
  RESULTS
  Self-designed NECM scaffold biomaterial for cell culture has no cytotoxicity, no acute and subacute systemic toxicity, and it did not cause inflammatory reaction.
  
  
  CONCLUSIONS
  Self-designed NECM has good biocompatibility and may become an ideal biological scaffold material for cell culture of tissue engineering.
authors.affiliation: Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Weijia
authors.initials: W
authors.lastname: Kong
authors.forename: Shengbin
authors.initials: S
authors.lastname: Bi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002356:Cartilage / Q000166:cytology; D005109:Extracellular Matrix; D006650:Histocompatibility Testing; D066298:In Vitro Techniques; D051379:Mice; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials