title: Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy.
abstract: The nido-carborane lipid, which has a double-tailed moiety, was synthesized from heptadecanol in 5 steps. Analysis in a transmission electron microscope by negative staining with uranyl acetate showed that the lipid formed a stable vesicle in which calcein was encapsulated. The lipid was incorporated into distearoylphosphatidylcholine (DSPC) liposomes at a very high concentration.
authors.affiliation: Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan. hiroyuki.nakamura@gakushuin.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyajima
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Takei
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kasaoka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Maruyama