Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population.
We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.
Matsuoka
Hiroyuki
H
Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan. hiroyuki@jichi.ac.jp.
Wang
Jichun
J
Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan.
Hirai
Makoto
M
Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan.
Arai
Meiji
M
Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan.
Yoshida
Shigeto
S
Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan.
Kobayashi
Tamaki
T
Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Jalloh
Amadu
A
Department of Advanced Medical Science, Nagoya University Graduate School of Medicine, Showa, Nagoya, Japan.
Lin
Khin
K
Parasitology Division, Department of Medical Research, Upper Myanmar, Myanmar.
Kawamoto
Fumihiko
F
Faculty of Medicine, Institute of Scientific Research, Oita University, Oita, Japan.
D005006:Ethnicity / Q000235:genetics; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D008288:Malaria / Q000175:diagnosis / Q000235:genetics; D009154:Mutation; D002052:Myanmar
D005954:Glucosephosphate Dehydrogenase