Centromere glue provides spindle cue.
During cell division, accurate distribution of the genome by the mitotic spindle requires that sister chromatids remain tethered until the right moment. Studies of an uncharacterized vertebrate protein, Sgo (Salic et al., 2004 [this issue of Cell]), reveal dual roles as a chromosome cohesion factor and a regulator of spindle microtubule dynamics.
Deehan
Renée
R
Department of Molecular and Cell Biology, University of California, Berkeley, 311 Life Sciences Addition, Berkeley, CA 94720, USA.
Heald
Rebecca
R
D000818:Animals; D002503:Centromere / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D018386:Kinetochores / Q000378:metabolism / Q000648:ultrastructure; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D008938:Mitosis / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism
D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C482640:Sgo1 protein, S cerevisiae