The genetic immunodeficiency disease, leukocyte adhesion deficiency, in humans, dogs, cattle, and mice.
This review highlights the genotype-phenotype relationship of the genetic immunodeficiency disease leukocyte adhesion deficiency (LAD) in humans, dogs, cattle, and mice, and provides assessment of the opportunities that each animal species provides in the understanding of leukocyte biology and in developing new therapeutic approaches to LAD in humans. This comparison is important since animal models of genetic diseases in humans provide the opportunity to test new therapeutic approaches in an appropriate, disease-specific model. The success of this approach is dependent on the relationship of the phenotype in the animal to the phenotype of the disease in humans.
Gu
Yu-Chen
YC
Experimental Transplantation and Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Bauer
Thomas R
TR
Ackermann
Mark R
MR
Smith
C Wayne
CW
Kehrli
Marcus E
ME
Starost
Matthew F
MF
Hickstein
Dennis D
DD
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D002417:Cattle; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D016023:Integrins / Q000276:immunology; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout
D015703:Antigens, CD; D016023:Integrins