title: [An animal model of alcoholic fatty liver and the prevention and treatment with New Qinggan Decoction].
abstract: OBJECTIVE
  To establish an animal model of alcoholic fatty liver (AFL) and to observe the prevention and treatment with New Qinggan Decoction (NQGD).
  
  
  METHODS
  Female SD rats were exposed to the mixture of white spirit and corn oil continuously for up to 6 weeks via an intragastric feeding protocol. The pathologic alteration of the liver and the changes of serum lipid were observed, and the effect of NQGD for preventing and treating AFL was studied.
  
  
  RESULTS
  Wide hepatic steatosis was induced in model group rats. Serum triglyceride (TG) and total cholesterol (TC) of the model group were higher than those of the normal group (P<0.01). Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of the model group were higher than those of the normal group (P<0.05). In NQGD group, hepatic steatosis was milder than that in the model group, and serum TG, TC, AST, ALT descended significantly as compared with the model group (P<0.01).
  
  
  CONCLUSIONS
  AFL model of rats established by feeding the mixture of white spirit and corn oil is similar to the episode of the human AFL, and is easy to intervene with medicine. NQGD can prevent the occurrence of AFL in this model.
authors.affiliation: Department of Infectious Diseases, General Hospital of Huabei Oil Field, Renqiu, Hebei Province 062552, China. huguojie2002@sina.com
authors.forename: Guo-Jie
authors.initials: GJ
authors.lastname: Hu
authors.forename: Dian-Gui
authors.initials: DG
authors.lastname: Li
authors.forename: Shi-Fang
authors.initials: SF
authors.lastname: Li
authors.forename: Zhen-Bin
authors.initials: ZB
authors.lastname: Li
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Li
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005235:Fatty Liver, Alcoholic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D008099:Liver / Q000473:pathology; D008516:Medicine, Chinese Traditional; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase