Anti-HIV activity of some synthetic lignanolides and intermediates.
The evaluation of the anti-HIV-1 activity of synthetic lignanolides and their intermediates is reported. The antiviral activity was studied through luciferase-based assays targeting the HIV-1 promoter activation induced by either, the HIV-1 Tat protein or the cellular transcription factor NF-kappaB, both known as crucial factors in HIV-1 replication. Among the compounds tested, three of them 2, 4 and 13 were further analysed for their anti-HIV-1 activity by recombinant virus assays, showing a suitable profile for development of novel anti-HIV-1 drugs.
Sancho
Rocío
R
Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Avda. Menéndez Pidal s/n 14004, Spain.
Medarde
Manuel
M
Sánchez-Palomino
Sonsoles
S
Madrigal
Blanca M
BM
Alcamí
José
J
Muñoz
Eduardo
E
San Feliciano
Arturo
A
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
D019380:Anti-HIV Agents; D017705:Lignans