title: Limited diagnostic agreement of quantitative sonography of the radius and phalanges with dual-energy x-ray absorptiometry of the spine, femur, and radius for diagnosis of osteoporosis.
abstract: OBJECTIVE
  The aim of our study was to evaluate the diagnostic agreement of quantitative sonography of the radius and proximal phalanx and dual-energy X-ray absorptiometry (DXA) of the radius, lumbar spine, and femoral neck for the detection of osteoporosis.
  
  
  METHODS
  In 95 women (mean age, 53 +/- 13 years) and 26 men (mean age, 53 +/- 13 years), DXA measurements of the lumbar spine (posterior-anterior, L1-L4) and the femoral neck, as well as quantitative sonography of the radius and proximal phalanx of the third finger were obtained. The percentage of patients below a given threshold was calculated for each imaging technique. A T score of less than -2.5 indicated presence of osteoporosis. Diagnostic agreement in identifying individuals with osteoporosis was assessed using kappa scores.
  
  
  RESULTS
  Between 14% and 22% of the patients were classified as osteoporotic after DXA of the various regions of interest of the radius, 31% after DXA of the spine, 43% after DXA of the femoral neck, 32% after quantitative sonography of the distal radius, and 34% after quantitative sonography of the phalanx of the third finger. Correlation coefficients between T values for quantitative sonography and those for DXA varied between not significant and 0.54 at the different regions. Kappa analysis showed the diagnostic agreement among quantitative sonography and DXA to be fair to moderate (kappa = 0.38-0.48). The highest agreement was between quantitative sonography of the proximal phalanx of the third finger and DXA of the total radius (kappa 0.48; p < 0.05).
  
  
  CONCLUSIONS
  Considerable diagnostic disagreement exists between quantitative sonography and DXA of the forearm, as is true for most quantitative techniques in the assessment of skeletal status. The lack of correlation makes quantitative sonography impractical for routine diagnostic use but might characterize different parameters related to bone quality.
authors.affiliation: Department of Radiology, University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria. christian.krestan@univie.ac.at
authors.forename: Christian R
authors.initials: CR
authors.lastname: Krestan
authors.forename: Stephan
authors.initials: S
authors.lastname: Grampp
authors.forename: Christine
authors.initials: C
authors.lastname: Henk
authors.forename: Philipp
authors.initials: P
authors.lastname: Peloschek
authors.forename: Herwig
authors.initials: H
authors.lastname: Imhof
mesh_terms: D015502:Absorptiometry, Photon; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D005385:Fingers / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis*; D011884:Radius / Q000000981:diagnostic imaging*; D013131:Spine / Q000000981:diagnostic imaging; D014463:Ultrasonography