[Functional dynamics of the right ventricle and pulmonary circulation in obstructive sleep apnea. Therapeutic consequences].
Obstructive sleep apnea (OSA) is common with an incidence of at least 500,000 patients in the German population. Typical symptoms are daytime sleepiness, headache in the morning, and snoring. Presumably obstructive sleep apnea via various mechanisms increases cardiovascular morbidity. Hypoxemia causes nocturnal hypertension in most of the patients. Nevertheless, about 20% of the patients develop daytime pulmonary hypertension and right heart dysfunction. Clinical and animal studies demonstrated right ventricular hypertrophy as a consequence of intermittent hypoxemia and pulmonary hypertension. Right ventricular hemodynamics differ essentially from left ventricular hemodynamics. Right ventricular function is substantially influenced by right ventricular afterload, which is mainly determined by pulmonary vascular resistance, and slightly influenced by preload. Application of continuous positive airway pressure (CPAP) via a nose mask normalizes nocturnal breathing disorders and reduces pre- and afterload, especially in patients with cardiomegaly. Therefore, CPAP generates positive effects on the myocardium.
Steiner
S
S
Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf. steinest@uni-duesseldorf.de
Strauer
B E
BE
D045422:Continuous Positive Airway Pressure / Q000379:methods*; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000503:physiopathology*; D011652:Pulmonary Circulation; D020127:Recovery of Function / Q000502:physiology; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology* / Q000628:therapy*; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology* / Q000628:therapy*