Variations in "rescuability" of immunoglobulin molecules from different forms of human lymphoma: implications for anti-idiotype vaccine development.
Idiotypic (Id) vaccination has shown promising results in patients with follicular lymphoma (FL). However, it still remains unclear whether the same approach might be suitable for the treatment of other B-cell malignancies. For this reason, we recently performed an interim analysis of patients proposed to receive this treatment at our center. The feasibility of employing idiotype vaccines was evaluated for five different B-cell malignancies in their first relapse, both in terms of induction and fusion, as well as overall treatment. Our data suggest that, unlike follicular lymphoma (87%), this approach is not feasible to treat other B-cell malignancies (0-20%) such as mantle cell, small lymphocytic, diffuse large cell and Burkitt's lymphoma (P < 0.01). The main difficulties encountered were technical problems related to the survival of idiotype-producing hybridomas (83%) and the early loss of idiotype production by growing hybridomas (17%). However, it remains possible that an idiotype vaccine might still be produced through molecular means for most, if not all cases of relapsing B-cell malignancies.
Rodríguez-Calvillo
Mercedes
M
Cell Therapy Area, Department of Hematology, University Clinic of Navarre and the Foundation for Applied Medical Research, Avda. Pio XII, 36-31008 Pamplona, Spain.
Inogés
Susana
S
López-Díaz de Cerio
Ascensión
A
Zabalegui
Natalia
N
Villanueva
Helena
H
Bendandi
Maurizio
M
D000917:Antibody Formation / Q000187:drug effects; D019496:Cancer Vaccines / Q000494:pharmacology; D000939:Epitopes / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology / Q000627:therapeutic use*; D015448:Leukemia, B-Cell / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000628:therapy*
D019496:Cancer Vaccines; D000939:Epitopes; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes