Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy.
Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (total dose 1702.5 mg). This may be the first such case reported in the literature.
Choi
Byung-Ryul
BR
Hospital for Rheumatic Diseases, Hanyang University, 17 Haengdang-Dong, Sungdong-Gu, Seoul 133-792, Korea.
Ahn
Myung-Ju
MJ
Lee
Woong Soo
WS
Kim
Tae-Hwan
TH
Bae
Sang-Cheol
SC
Jun
Jae-Bum
JB
D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D004915:Leukemia, Erythroblastic, Acute / Q000209:etiology* / Q000473:pathology; D008727:Methotrexate / Q000627:therapeutic use*; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D006886:Hydroxychloroquine; D005492:Folic Acid; D008727:Methotrexate