New sphingosines from a gorgonian, Pseudopterogorgia australiensis Ridley, of the Indian Ocean.
Two new sphingosines, (2S,3R)-2-(docosanoyl amino)nonadecane-1,3-diol (1) and (2S,3S,4R)-2-[(2'R)-2'-hydroxynonadecanoylamino]nonadecane-1,3,4-triol (3), along with the known (2S,3R,4E)-2-(heptadecanoylamino)octadec-4-ene-1,3-diol, have been isolated from Pseudopterogorgia australiensis, of the Indian Ocean. The structures were deduced from spectral and chemical methods. Compounds 1-3 showed moderate antibacterial activity.
Krishna
N
N
Department of Pharmaceutical Sciences and Department of Organic Chemistry, Andhra University, Visakhapatnam 530 003, India.
Muralidhar
P
P
Kumar
M Muralikrishna
MM
Rao
D Venkata
DV
Rao
Ch Bheemasankara
ChB
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D019156:Indian Ocean; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013110:Sphingosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
C492419:(2S,3R)-2-(docosanoylamino)nonadecane-1,3-diol; C492420:(2S,3S,4R)-2-((2'R)-2'-hydroxynonadecanoylamino)nonadecane-1,3,4-triol; D000900:Anti-Bacterial Agents; D013110:Sphingosine