title: Acute respiratory distress syndrome due to systemic lupus erythematosus with hemophagocytic syndrome: an autopsy report.
abstract: This report concerns a patient with systemic lupus erythematosus (SLE) who died of acute respiratory distress syndrome (ARDS) 1 day after the onset of pulmonary symptoms. Autopsy demonstrated severe hemophagocytosis in the bone marrow and histopathology indicating a marked increase in vascular permeability in both lungs and kidneys. In this patient, active SLE and associated hemophagocytic syndrome may have induced an increase in the production of inflammatory cytokines, which immediately induced ARDS. Since fatal ARDS can occur as a life-threatening complication of SLE, careful observation is necessary, particularly when there are clinical findings suggestive of associated hemophagocytic syndrome.
authors.affiliation: Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621 Matsumoto, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kaneko
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sekijima
authors.forename: Waki
authors.initials: W
authors.lastname: Hosoda
authors.forename: Takahisa
authors.initials: T
authors.lastname: Gono
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hoshi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shimojo
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D011654:Pulmonary Edema / Q000209:etiology / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000473:pathology