Synthesis, characterization and in vitro anti-amoebic activity of new palladium(II) complexes with 5-nitrothiophene-2-carboxaldehyde N(4)-substituted thiosemicarbazones.
Reaction between [Pd(DMSO)(2)Cl(2)] (DMSO=dimethylsulfoxide) and N(4)-substituted thiosemicarbazones derived from 5-nitrothiophene-2-carboxaldehyde (L) afforded the complexes [Pd(L)Cl(2)]. These new complexes have been characterized by elemental analyses and spectroscopic studies. Spectroscopic studies reveal that thionic sulfur and azomethine nitrogen atom of thiosemicarbazones are coordinated to metal ion. The testing of the anti-amoebic activity of these complexes against the protozoan parasite Entamoeba histolytica suggests that compound 9, 10, and 11 might be endowed with important anti-amoebic properties since they showed less IC(50) values than metronidazole. Moreover, compound 11 displays notable amoebicidal activity than metronidazole (IC(50) values of 0.79 microM vs 1.93 microM, respectively).
Bharti
Neelam
N
Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Athar
Fareeda
F
Maurya
Mannar R
MR
Azam
Amir
A
D000447:Aldehydes / Q000737:chemistry*; D000563:Amebicides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D004748:Entamoeba histolytica / Q000187:drug effects; D020128:Inhibitory Concentration 50; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry*; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000494:pharmacology
C409455:5-nitrothiophene-2-carboxaldehyde; D000447:Aldehydes; D000563:Amebicides; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D013882:Thiosemicarbazones; D010165:Palladium