title: [Discussion on clinical efficacy of Hypericum perforatum for depression abroad].
abstract: The development of molecular pharmacology and neuropharmacology accelerated the studies on molecular mechanism of Hypericum perforatum for depression. The clinical trials indicated that this galenical was superior to the traditional synthetic drugs for antidepression. This preparation had good tolerability and safety. Clinical pharmacokinetics and pharmacodynamics provided further evidence for clinical application of Hypericum. The clinical efficacy of Hypericum for depression was notable and credible.
authors.affiliation: Laboratory of Pharmacognosy and Natural Medicinal Chemistry, School of Pharmacy, Sun Yat Sen University, Guangzhou, Guangdong Province 510275, China. ls39@zsu.edu.cn
authors.forename: De-Po
authors.initials: DP
authors.lastname: Yang
authors.forename: Liang-Chun
authors.initials: LC
authors.lastname: Gan
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Hu
mesh_terms: D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D020902:Hypericum; D006967:Hypersensitivity / Q000209:etiology; D008517:Phytotherapy / Q000009:adverse effects; D010936:Plant Extracts / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts