title: Genes encoding subunits of stable complexes are clustered on the yeast chromosomes: an interpretation from a dosage balance perspective.
abstract: Genomic evidence for colocalization of functionally related genes on eukaryote chromosomes is mounting. Here we show that a statistically significant fraction of yeast genes coding for subunits of stable complexes are located within 10-30 kb of each other. Clustering of genes encoding subunits of complexes may ensure better coregulation and maintain the right stoichiometry of complexes upon duplication of chromosomal segments.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, England.
authors.forename: Sarah Amalia
authors.initials: SA
authors.lastname: Teichmann
authors.forename: Reiner Albert
authors.initials: RA
authors.lastname: Veitia
mesh_terms: D015825:Chromosomes, Fungal / Q000235:genetics; D018628:Gene Dosage; D005800:Genes, Fungal; D005810:Multigene Family; D021122:Protein Subunits / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*
chemical_list: D021122:Protein Subunits; D029701:Saccharomyces cerevisiae Proteins