Circadian phase difference of leptin in android versus gynoid obesity.
A circadian rhythm in serum leptin, measured every 4 h for 24 h, characterizes normal-weight women (N = 14), and women with gynoid (N = 17) or android (N = 26) obesity, peaking around midnight (P < 0.05), but differing by about 3 h between android and gynoid women (P < 0.01). Obesity is associated with a higher MESOR (rhythm-adjusted mean; P < 0.001) and a smaller relative circadian amplitude (P < 0.05). Gynoid obesity is associated with a larger circadian amplitude of cortisol (P < 0.05), whereas android obesity is associated with a larger circadian amplitude and a higher MESOR of insulin (P < 0.05). Understanding putative mechanisms underlying different body fat distribution may lead to improved chronotherapeutic measures.
Perfetto
Federico
F
Department of Internal Medicine, Facoltà di Medicina e Chirurgia, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. perfetto@unifi.it
Tarquini
Roberto
R
Cornélissen
Germaine
G
Mello
Giorgio
G
Tempestini
Alessio
A
Gaudiano
Paola
P
Mancuso
Francesco
F
Halberg
Franz
F
D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000145:classification / Q000503:physiopathology*; D013997:Time Factors
D007328:Insulin; D020738:Leptin; D006854:Hydrocortisone