Primary, solitary, adult T-cell leukemia / lymphoma of the descending colon.
We herein report a patient with adult T-cell leukemia/lymphoma (ATLL) of the descending colon. A 64-year-old man was admitted to our hospital complaining of left lower abdominal pain. Endoscopic examination revealed an ulcerative tumor in the descending colon that was diagnosed as T-cell lymphoma by biopsy. Neither distant organ metastasis nor lymph node swelling was observed by radiographic examinations. Curative excision with left hemicolectomy and regional lymph node dissection was performed. Surgical sections contained ulcerative and superficially elevated lesions; these were continuous with each other. Histological examination revealed diffuse proliferation of medium-sized abnormal lymphoid cells. Immunohistochemically, these lymphoid cells were positive for UCHL-1/CD45RO and CD3 and negative for CD79a, indicating that the tumor was a primary malignant T-cell lymphoma of the descending colon. Integration of the proviral DNA of human T-lymphotropic virus type 1 (HTLV-1) was confirmed by Southern blotting analysis.
Hidaka
Hideki
H
First Department of Surgery, Miyazaki Medical College, 5200 Kihara, Kiyotake, 889-1692 Miyazaki, Japan.
Hotokezaka
Masayuki
M
Iwamura
Takeshi
T
Moriguchi
Sayaka
S
Marutsuka
Kousuke
K
Toyama
Takanori
T
Chijiiwa
Kazuo
K
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D017252:CD3 Complex / Q000032:analysis; D051925:CD79 Antigens; D002455:Cell Division / Q000502:physiology; D017024:Chemotherapy, Adjuvant; D003082:Colectomy; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D003131:Combined Modality Therapy; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D015368:Human T-lymphotropic virus 1 / Q000235:genetics; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D017493:Leukocyte Common Antigens / Q000032:analysis; D008197:Lymph Node Excision; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D016662:Virus Integration / Q000235:genetics
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D017252:CD3 Complex; D051925:CD79 Antigens; C497881:CD79A protein, human; D004279:DNA, Viral; D011947:Receptors, Antigen, B-Cell; D017493:Leukocyte Common Antigens; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1