title: Clinical characterization and survival of adult patients awaiting liver transplantation in Chile.
abstract: Liver transplantation has become widely used for patients with decompensated disease. Because of the shortage of donors, each year more patients die on the waiting list. Our aim was to characterize and evaluate the final outcomes of all listed candidates for liver transplantation during a 34-month period. We retrospectively evaluated all adults listed between January 2000 and November 2002. Sixty-three patients (37 women, mean age 45.8 years) were listed: 48 due to chronic liver disease and 15 for a highly urgent transplantation due to acute liver failure. The main etiology of chronic disease was alcoholic (22%) or primary biliary cirrhosis (17%). Of 52 chronic patients, 26 (50%) were transplanted with a mean waiting time of 168 days. Among the others, 8 died (15%) while awaiting transplantation, 3 (5%) were removed from the list, and 15 patients still await transplantation (28%). Among acute liver failure patients, the main etiologies were autoimmune (25%) and medication induced (25%). Of 15 acute patients, 6 (37.5%) have been transplanted at a mean waiting time of 6.8 days with 100% survival posttransplantation. In this cohort, 6 patients (37.5%) died while awaiting liver transplantation, and 4 (25%) survived with medical support. In conclusion, the severity of liver disease and death rate among our waiting list was similar to that observed in developed countries. It seems reasonable to review our current allocation system based on waiting time on the list. We will have to decide whether to transplant sicker patients or those with hepatocarcinoma (as in the United States recently with the MELD system), thereby possibly decreasing the mortality rate on the waiting list at the expense of higher costs and more difficult postoperative care or to just keep our current policy.
authors.affiliation: Liver-Transplant Unit, Department of Medicine and Surgery, Clinica Alemana de Santiago, Santiago, Chile. rzapata@alemana.cl
authors.forename: R
authors.initials: R
authors.lastname: Zapata
authors.forename: F
authors.initials: F
authors.lastname: Innocenti
authors.forename: E
authors.initials: E
authors.lastname: Sanhueza
authors.forename: R
authors.initials: R
authors.lastname: Humeres
authors.forename: H
authors.initials: H
authors.lastname: Rios
authors.forename: L
authors.initials: L
authors.lastname: Suarez
authors.forename: J M
authors.initials: JM
authors.lastname: Palacios
authors.forename: M
authors.initials: M
authors.lastname: Rius
authors.forename: J
authors.initials: J
authors.lastname: Hepp
mesh_terms: D000328:Adult; D002677:Chile; D006801:Humans; D008107:Liver Diseases / Q000401:mortality* / Q000601:surgery*; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D016019:Survival Analysis; D014850:Waiting Lists