Penasulfate A, a new alpha-glucosidase inhibitor from a marine sponge Penares sp.
A new alpha-glucosidase inhibitor, penasulfate A, has been isolated from a marine sponge Penares sp.(1) Its structure was elucidated by spectral and chemical methods to be a scalemic mixture of methyl pipecolates acylated with a novel sulfated fatty acid.
Nakao
Yoichi
Y
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Maki
Takashi
T
Matsunaga
Shigeki
S
van Soest
Rob W M
RW
Fusetani
Nobuhiro
N
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010875:Pipecolic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
D004791:Enzyme Inhibitors; D005227:Fatty Acids; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010875:Pipecolic Acids; C492413:penasulfate A