title: Paraneoplastic cerebellar degeneration (PCD) associated with squamous cell carcinoma of the lung.
abstract: We report a case of a 71-year-old man who presented with cerebellar dysfunction. He was diagnosed as having squamous cell carcinoma of the lung (T2N3M0, Stage IIIB). No anti-onconeural antibodies were found in his serum. Cerebral spinal fluid (CSF) examination showed mild mononuclear pleocytosis alone. Magnetic resonance imaging (MRI) of the brain and spinal cord revealed no abnormalities. At autopsy, there was complete disappearance of Purkinje cells with reactive astrocytosis. These findings are compatible with paraneoplastic cerebellar degeneration (PCD). To our knowledge, no case of PCD has been reported previously in patients with squamous cell carcinoma of the lung.
authors.affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo.
authors.forename: Jun
authors.initials: J
authors.lastname: Konishi
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Kanako
authors.initials: K
authors.lastname: Chikai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagashima
authors.forename: Koichiro
authors.initials: K
authors.lastname: Sakai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kinoshita
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Dosaka-Akita
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D001344:Autopsy; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009367:Neoplasm Staging; D020362:Paraneoplastic Cerebellar Degeneration / Q000150:complications* / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed