title: Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice.
abstract: Chronic restraint stress, administered during early infection with Theiler's virus, was found to exacerbate the acute central nervous system (CNS) viral infection and the subsequent demyelinating phase of disease (an animal model of Multiple Sclerosis (MS)) in SJL male and female mice. During early infection, stressed mice displayed decreased body weights and spontaneous activity; while increased behavioral signs of illness and plasma corticosterone (CORT) levels. During the subsequent chronic demyelinating phase of disease, previously stressed mice had greater behavioral signs of the chronic phase, worsened rotarod performance, and increased inflammatory lesions of the spinal cord. In addition, mice developed autoantibodies to myelin basic protein (MBP), proteolipid protein peptide (PLP139-151), and myelin oligodendrocyte glycoprotein peptide (MOG33-55).
authors.affiliation: Department of Psychology, Behavioral and Cellular Neuroscience Program, College of Liberal Arts, Texas A&M University, College Station, TX 77843-4235, USA.
authors.forename: Amy N
authors.initials: AN
authors.lastname: Sieve
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Steelman
authors.forename: Colin R
authors.initials: CR
authors.lastname: Young
authors.forename: Ralph
authors.initials: R
authors.lastname: Storts
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Welsh
authors.forename: C Jane R
authors.initials: CJ
authors.lastname: Welsh
authors.forename: Mary W
authors.initials: MW
authors.lastname: Meagher
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001522:Behavior, Animal / Q000502:physiology; D001835:Body Weight / Q000276:immunology; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D020278:Demyelinating Autoimmune Diseases, CNS / Q000276:immunology / Q000523:psychology* / Q000821:virology; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000276:immunology*; D004435:Eating / Q000276:immunology / Q000523:psychology; D005260:Female; D007108:Immune Tolerance / Q000276:immunology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology / Q000523:psychology* / Q000821:virology; D009185:Myelin Proteins / Q000276:immunology; D009187:Myelitis / Q000276:immunology / Q000523:psychology / Q000821:virology; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D017945:Theilovirus / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D009185:Myelin Proteins; D003345:Corticosterone