Paraneoplastic cerebellar degeneration (PCD) associated with squamous cell carcinoma of the lung.
We report a case of a 71-year-old man who presented with cerebellar dysfunction. He was diagnosed as having squamous cell carcinoma of the lung (T2N3M0, Stage IIIB). No anti-onconeural antibodies were found in his serum. Cerebral spinal fluid (CSF) examination showed mild mononuclear pleocytosis alone. Magnetic resonance imaging (MRI) of the brain and spinal cord revealed no abnormalities. At autopsy, there was complete disappearance of Purkinje cells with reactive astrocytosis. These findings are compatible with paraneoplastic cerebellar degeneration (PCD). To our knowledge, no case of PCD has been reported previously in patients with squamous cell carcinoma of the lung.
Konishi
Jun
J
First Department of Medicine, Hokkaido University School of Medicine, Sapporo.
Yamazaki
Koichi
K
Chikai
Kanako
K
Nagashima
Kazuo
K
Sakai
Koichiro
K
Kinoshita
Ichiro
I
Dosaka-Akita
Hirotoshi
H
Nishimura
Masaharu
M
D000368:Aged; D001344:Autopsy; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009367:Neoplasm Staging; D020362:Paraneoplastic Cerebellar Degeneration / Q000150:complications* / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed