title: Role of the HLA-DP Glu 69 and the TNF-alpha TNF-alpha 2 gene markers in susceptibility to beryllium hypersensitivity.
abstract: Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of beryllium dusts, characterized by the accumulation of CD4+ T cells and macrophages in the lower respiratory tract. Beryllium presentation to CD4+ T cells from patients with berylliosis results in T cell activation and these Be-specific CD4+ T cells undergo clonal proliferation and Th1-type cytokine production such as interleukin-2, interferon-gamma and tumor necrosis factor-alpha. In exposed workers, genetic susceptibility to this granulomatous disorder is associated with major histocompatibility gene and the TNF-alpha gene. The HLA-DP glutamic 69 residue was shown to be the MHC genetic marker associated with disease susceptibility; furthermore the TNF-alpha TNFA-308*2 allele was found to be independently associated with HLA-DP Glu69 in the determination of berylliosis risk.
authors.affiliation: Dipartimento di Medicina Interna, Università di Roma Tor Vergata, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Rogliani
authors.forename: M
authors.initials: M
authors.lastname: Amicosante
authors.forename: F
authors.initials: F
authors.lastname: Berretta
authors.forename: C
authors.initials: C
authors.lastname: Dotti
authors.forename: M
authors.initials: M
authors.lastname: Bocchino
authors.forename: K M
authors.initials: KM
authors.lastname: O'Donnell
authors.forename: C
authors.initials: C
authors.lastname: Saltini
mesh_terms: D000483:Alleles; D001607:Berylliosis / Q000235:genetics* / Q000378:metabolism; D001608:Beryllium / Q000276:immunology*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D018698:Glutamic Acid / Q000235:genetics; D006682:HLA-DP Antigens / Q000235:genetics* / Q000502:physiology; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000502:physiology
chemical_list: D005819:Genetic Markers; D006682:HLA-DP Antigens; D014409:Tumor Necrosis Factor-alpha; D018698:Glutamic Acid; D001608:Beryllium