[Preliminary studies on pathogenic factors of human cytomegalovirus infection].
OBJECTIVE
To investigate the pathogenic factors of human cytomegalovirus (HCMV) infections.


METHODS
Totally 36 serum samples were obtained from early pregnant woman and examined with ELISA for anti-HCMV antibody IgG and IgM. After artificial abortion,chorionic villus and decidua were also examined with polymerase chain reaction (PCR) for HCMV-DNA. When the results of PCR were positive, pathological changes of these chorionic villus and decidua were analyzed.


RESULTS
The results showed that only 10 samples were PCR positive while IgG and/or IgM antibody to HCMV was positive. After infection with HCMV, different changes occurred in chorionic villus and decidual trophoblastic cells placental villus were hyperplasic and decidua cells degenerated and necrotized followed by lymphocytes infiltration.


CONCLUSIONS
These pathological changes may be one of pathogenic factors of HCMV.
Li
Ai-bin
AB
The Ren Min Hospital of Wu Han University, Wuhan 430060, China.
Liu
Qian
Q
Xia
Liang-bin
LB
Li
Yu-hong
YH
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002824:Chorionic Villi / Q000473:pathology / Q000821:virology; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000473:pathology*; D004279:DNA, Viral / Q000032:analysis; D003656:Decidua / Q000473:pathology / Q000821:virology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000821:virology*
D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M