title: Antidepressant medication use and non-Hodgkin's lymphoma risk: no association.
abstract: Animal and human studies have suggested that antidepressant medications may be associated with several cancers. The authors evaluated the association between antidepressant medication use and the risk of non-Hodgkin's lymphoma using a Canadian population-based case-control study, the National Enhanced Cancer Surveillance Study. Non-Hodgkin's lymphoma cases (n=638) diagnosed in 1995-1996 were identified using the Ontario Cancer Registry, and controls (n=1,930) were identified from the Ontario Ministry of Finance Property Assessment Database. Antidepressant medication use was ascertained using a self-administered questionnaire. Multivariate logistic regression was used to estimate odds ratios. "Ever" use of antidepressant medications was not associated with non-Hodgkin's lymphoma risk. The odds ratio for non-Hodgkin's lymphoma with 25 or more months of tricyclic antidepressant medication use was 1.6; however, this was nonsignificant. Duration or history of use or individual types of antidepressant medications were not associated with non-Hodgkin's lymphoma risk. These findings do not support an increased risk of non-Hodgkin's lymphoma with antidepressant medication use.
authors.affiliation: Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, Canada.
authors.forename: Saira
authors.initials: S
authors.lastname: Bahl
authors.forename: Michelle
authors.initials: M
authors.lastname: Cotterchio
authors.forename: Nancy
authors.initials: N
authors.lastname: Kreiger
authors.forename: Neil
authors.initials: N
authors.lastname: Klar
mesh_terms: D017677:Age Distribution; D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000145:classification; D016022:Case-Control Studies; D015984:Causality; D016009:Chi-Square Distribution; D015986:Confounding Factors, Epidemiologic; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000145:classification / Q000453:epidemiology*; D008297:Male; D008487:Medical History Taking; D015999:Multivariate Analysis; D016017:Odds Ratio; D009864:Ontario / Q000453:epidemiology; D011159:Population Surveillance; D012042:Registries; D017678:Sex Distribution; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents