title: Increase of resistance to macrolides in invasive Streptococcus pneumoniae in Spain (2000-2001).
abstract: This study examined the antimicrobial resistance of 1,278 invasive Streptococcus pneumoniae isolates from 41 Spanish laboratories participating in the European Antimicrobial Resistance Surveillance System (EARSS) during 2000 and 2001. Twenty-nine laboratories participated during both years and provided 950 of the isolates. Each laboratory used its own susceptibility testing methods. External quality assessment was performed annually by each participating laboratory. Significant increases in penicillin and erythromycin resistance were observed between 2000 and 2001. This increase was particularly noticeable in isolates from the laboratories participating during both years and in isolates from children and elderly patients.
authors.affiliation: Centro Nacional de Microbiología, 28220 Majadahonda, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Oteo
authors.forename: J
authors.initials: J
authors.lastname: Campos
authors.forename: S
authors.initials: S
authors.lastname: Cruchaga
authors.forename: G
authors.initials: G
authors.lastname: Baquero
authors.forename: E
authors.initials: E
authors.lastname: Lázaro
authors.forename: M
authors.initials: M
authors.lastname: Madurga
authors.forename: F J
authors.initials: FJ
authors.lastname: de Abajo
authors.forename: F
authors.initials: F
authors.lastname: Baquero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D011159:Population Surveillance; D013030:Spain / Q000453:epidemiology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides