Repeatability of noninvasive surrogates of endothelial function.
We compared the repeatability of 2 ultrasonographic methods for endothelial function assessment at brachial artery-flow-mediated dilation (FMD) and post-ischemic peak blood flow (PBF). Twenty healthy volunteers were examined twice within 10 days; coefficients of variation were 13.8% for PBF and 41.0% for FMD. PBF seems to be superior to FMD in terms of reproducibility. Consequently, smaller noninvasive studies of endothelial function can be designed utilizing PBF compared with FMD.
Malik
Jan
J
Third Department of Medicine, General University Hospital, Prague, Czech Republic. jmali@lf1.cuni.cz
Wichterle
Dan
D
Haas
Tomas
T
Melenovsky
Vojtech
V
Simek
Jan
J
Stulc
Tomas
T
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001916:Brachial Artery / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D014463:Ultrasonography / Q000379:methods*; D014664:Vasodilation / Q000502:physiology