title: Examination of the reactivity of hydroxy groups in multioxygenated cyclohexanoids: synthetic study toward cytotoxic pericosine B.
abstract: The reactivity of two hydroxy groups in some multioxygenated cyclohexanoids was examined for basic study of the synthesis of the cytotoxic marine natural product pericosine B and related compounds. Differences in reactivity for O-methylation or O-acylation among substrates were observed.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, Japan. usami@gly.oups.ac.jp
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Usami
authors.forename: Atsushi
authors.initials: A
authors.lastname: Numata
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012765:Shikimic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; C496390:methyl 3,4-O-isopropylidene-6-epishikimate; C496389:pericosine B; D012765:Shikimic Acid