title: Malignant melanoma of nasal cavity: report of 16 Japanese patients.
abstract: BACKGROUND
  Primary malignant melanoma of the nasal cavity is a rare disease that has a poor prognosis. There are significant racial differences in the incidence of melanomas in the nasal cavity.
  
  
  METHODS
  Sixteen Japanese patients treated at the Hospital of Tokyo University were reviewed retrospectively.
  
  
  RESULTS
  Fourteen patients were treated with surgery. Two patients received treatment with radiotherapy alone. Seven patients had microscopically negative surgical margins and seven patients had positive surgical margins. The 2- and 5-year actuarial survival rates for all patients were 63.6 and 31.8%, respectively. No statistically significant difference could be shown in the overall survival rate between patients with positive surgical margins and those with negative surgical margins.
  
  
  CONCLUSIONS
  Clinical features of nasal melanoma in Japanese are not different from nasal melanoma in Caucasians. The negative surgical margins were not predictive of a better prognosis.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1 Bunkyo-ku, Tokyo 113-8655, Japan. muneo@interlink.or.jp
authors.forename: Muneo
authors.initials: M
authors.lastname: Nakaya
authors.forename: Masato
authors.initials: M
authors.lastname: Mochiki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yuge
authors.forename: Kazunari
authors.initials: K
authors.lastname: Nakao
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakamura
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugasawa
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008545:Melanoma / Q000208:ethnology* / Q000401:mortality / Q000628:therapy; D008875:Middle Aged; D009296:Nasal Cavity; D009297:Nasal Mucosa / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000208:ethnology* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate