title: A fast algorithm for functional mapping of complex traits.
abstract: By integrating the underlying developmental mechanisms for the phenotypic formation of traits into a mapping framework, functional mapping has emerged as an important statistical approach for mapping complex traits. In this note, we explore the feasibility of using the simplex algorithm as an alternative to solve the mixture-based likelihood for functional mapping of complex traits. The results from the simplex algorithm are consistent with those from the traditional EM algorithm, but the simplex algorithm has considerably reduced computational times. Moreover, because of its nonderivative nature and easy implementation with current software, the simplex algorithm enjoys an advantage over the EM algorithm in the dynamic modeling and analysis of complex traits.
authors.affiliation: Department of Statistics, University of Florida, Gainesville, Florida 32611, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
authors.forename: Chang-Xing
authors.initials: CX
authors.lastname: Ma
authors.forename: George
authors.initials: G
authors.lastname: Casella
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D008957:Models, Genetic; D015233:Models, Statistical; D040641:Quantitative Trait Loci