title: [Influence of electro-acupuncture of Neiguan on plasmic concentrations of NO and TNFalpha in endotoxin shock rats].
abstract: OBJECTIVE
  To observe the effect of electro-acupuncture of Neiguan (PC 6) on mean systemic arterial blood pressure and plasmic concentrations of NO and TNFalpha in endotoxin shock rats.
  
  
  METHODS
  The model of endotoxin shock was induced by lipopolysaccharide (1.5 mg/kg i.v.) and D-galactosamine (100 mg/kg i.p.). Aminoguanidine (100 mg/kg i.p.) and electro-acupuncture of bilateral Neiguan (PC 6) were administered. A catheter was inserted into the right subclavian artery to record the change of blood pressure and the blood was abstracted out and centrifuged to determine the NO and TNFalpha concentrations.
  
  
  RESULTS
  Electro-acupuncture of Neiguan (PC 6) retrieved the blood pressure and reduced the plasmic NO and TNFalpha concentrations.
  
  
  CONCLUSIONS
  Electro-acupuncture of Neiguan (PC 6) expresses an anti-endotoxin shock effect by repressing the plasmic NO and TNFalpha concentrations smoothly and retrieving the blood pressure stably.
authors.affiliation: Departmant of Anatomy, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province 510405, China. li_hui@163.net
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.forename: Shao-Hui
authors.initials: SH
authors.lastname: Du
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Li
authors.forename: Dong-Feng
authors.initials: DF
authors.lastname: Chen
mesh_terms: D015669:Acupuncture Points; D000818:Animals; D001794:Blood Pressure; D015671:Electroacupuncture; D005260:Female; D006146:Guanidines / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012772:Shock, Septic / Q000097:blood / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D006146:Guanidines; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; C004479:pimagedine