Correlation between blood group phenotype and virulence properties of Escherichia coli in patients with chronic urinary tract infection.
A predisposition to urinary tract infection (UTI) is associated with the expression of P1 as well as the presence of ABO blood group antigen on the boundary layer and with the secretor state. Infectious microorganisms interfere with specific molecules on epithelial cells, these are antigens of the P and ABO blood group system. The blood group phenotype was examined in 53 women (age 42 +/- 12 years) with chronic non-obstructive UTI. The diagnosis was established on the basis of clinical history as well as clinical laboratory and radiological findings. The ABO phenotype and the P1 antigen were analysed by anti-A and anti-B as well as anti-P1 serum. The Lewis phenotyping was performed by incubating erythrocytes with anti-Le(a) and anti-Le(b) serum. In all patients, the blood group status were investigated. The proportion of persons with B-phenotype was 23% (the incidence of this feature in the German population is 14.5%). P1 antigen was found in 76% patients. In comparison with P1 antigen-negative individuals, P1 antigen-positive persons have a longer disease history and suffer more frequently from symptomatic events as well as destructive renal changes. The Le (a)-antigen was detected in 82% and the Le (b)-phenotype was observed in 18% of patients. The blood group phenotypes (ABO, Lewis and P1 antigens) represent an interesting natural aspect of local defence system against the invasive efforts of uropathogens. Antigen structures on uroepithelial cells for example, the glycolipids of the P antigen, serve as receptors for adhesion of microorganisms.
Ziegler
T
T
DRK-Krankenhaus Sondershausen GmbH, Abteilung fur Innere Medizin, Hospitalstrasse 2, 99706 Sondershausen, Germany.
Jacobsohn
N
N
Fünfstück
R
R
D000017:ABO Blood-Group System / Q000145:classification* / Q000276:immunology*; D000328:Adult; D002908:Chronic Disease; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000276:immunology* / Q000382:microbiology; D005260:Female; D005915:Globosides / Q000145:classification / Q000276:immunology; D006460:Hemolysin Proteins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D014552:Urinary Tract Infections / Q000276:immunology* / Q000382:microbiology; D014774:Virulence
D000017:ABO Blood-Group System; D005915:Globosides; D006460:Hemolysin Proteins; C480041:galactopyranosyl-1-4-paragloboside