title: [Effect of topical application of a Rho-kinase inhibitor on the erectile response in rats].
abstract: OBJECTIVE
  To investigate the effect of Rho-kinase inhibitor applied topically on the penile erection and systemic circulation of rats.
  
  
  METHODS
  Y-27632 was applied to the surface of the tunica albuginea or to the penile skin of rats, and the changes of CCP/MAP were observed continuously.
  
  
  RESULTS
  Both methods of drug administration resulted in a marked increase in the erectile response both with and without stimulation of the innervation of the penile vasculature. Some doses of the drug were also found to reduce systemic blood pressure.
  
  
  CONCLUSIONS
  Inhibitors of Rho-kinase may represent a new and promising method of treatment for erectile dysfunction.
authors.affiliation: Department of Urology, the Affiliated Drum Tower Hospital of Nanjing University Medical College, Nanjing, Jiangsu 210008, China. ytdai@hotmail.com
authors.forename: Yutian
authors.initials: Y
authors.lastname: Dai
authors.forename: Zeyu
authors.initials: Z
authors.lastname: Sun
authors.forename: Kanchan
authors.initials: K
authors.lastname: Chitaley
authors.forename: R Clinton
authors.initials: RC
authors.lastname: Webb
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Mills
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Lewis
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D011725:Pyridines; C108830:Y 27632