Extensive genomic polymorphism within Mycobacterium avium.
We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.
Semret
Makeda
M
McGill University Health Center, Montreal, Quebec, Canada.
Zhai
Gary
G
Mostowy
Serge
S
Cleto
Cynthia
C
Alexander
David
D
Cangelosi
Gerard
G
Cousins
Debby
D
Collins
Desmond M
DM
van Soolingen
Dick
D
Behr
Marcel A
MA
D002876:Chromosomes, Bacterial / Q000235:genetics*; D004269:DNA, Bacterial / Q000032:analysis* / Q000235:genetics; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D009162:Mycobacterium avium / Q000235:genetics* / Q000378:metabolism; D016927:Mycobacterium avium subsp. paratuberculosis / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D010080:Oxazoles / Q000378:metabolism; D011110:Polymorphism, Genetic
D004269:DNA, Bacterial; D010080:Oxazoles; C018608:mycobactins