[Morphochemical characteristic of rat brain structures after exposure to delta-sleep inducing peptide following long-term amphetamine administration].
The aim of this work, that was carried out using Wistar rats, was to characterize the response of neurons of different morphofunctional types to amphetamine administration and to study the possibility of correction of these changes by delta-sleep inducing peptide (DSIP). Single intraperitoneal injection of 60 microg/kg of DSIP following a long term amphetamine administration (2.5 mg/kg for 3 weeks) was shown to result in normalization of brain metabolism, that was disturbed by the drug. The correcting DSIP effect was found in rat brain structures judging by the parameters of the state of proteins in neurons of sensomotor cortex and caudate nucleus and by the activity of enzymes of neurotransmitter metabolism, such as type A and B monoamine oxidases and acetylcholine esterase, that was determined in subfractions of the same brain structures. DSIP modulating effect in phenamine stereotypy supports its role as an adaptogen of intercenter relations in CNS pathology.
Gershteĭn
L M
LM
Dovedova
E L
EL
Khrustalev
D A
DA
D000110:Acetylcholinesterase / Q000378:metabolism; D000661:Amphetamine / Q000633:toxicity*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D002421:Caudate Nucleus / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D002540:Cerebral Cortex / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D015259:Dopamine Agents / Q000633:toxicity*; D006651:Histocytochemistry; D007274:Injections, Intraperitoneal; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001679:Biogenic Amines; D015259:Dopamine Agents; D018377:Neurotransmitter Agents; D003701:Delta Sleep-Inducing Peptide; D000661:Amphetamine; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase