title: Trends and innovations in industrial biocatalysis for the production of fine chemicals.
abstract: Biocatalysis has become an established technology for the industrial manufacture of fine chemicals. In recent years, a multitude of chemical companies have embraced biocatalysis for the manufacture of desired stereoisomers, and new or improved methods for the synthesis of enantiomerically pure alpha- and beta-amino acids, amines, amides, peptides, nitriles, alcohols, organic acids and epoxides have emerged. Furthermore, the selectivity and mild operational conditions of biocatalysts are increasingly applied in industry to modify complex target molecules. These recent innovations in the manufacture of industrial fine chemicals using biocatalysis are discussed from an industrial perspective.
authors.affiliation: DSM Research Campus Geleen, Advanced Synthesis & Catalysis, PO Box 18, 6160 MD Geleen, The Netherlands.
authors.forename: Sven
authors.initials: S
authors.lastname: Panke
authors.forename: Martin
authors.initials: M
authors.lastname: Held
authors.forename: Marcel
authors.initials: M
authors.lastname: Wubbolts
mesh_terms: D000438:Alcohols / Q000378:metabolism; D000588:Amines / Q000378:metabolism; D000596:Amino Acids / Q000096:biosynthesis*; D001711:Biotransformation; D002241:Carbohydrates / Q000096:biosynthesis; D002384:Catalysis; D002617:Chemical Industry / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends*; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D006867:Hydrolases / Q000378:metabolism; D007218:Industrial Microbiology / Q000379:methods / Q000706:statistics & numerical data / Q000639:trends; D010088:Oxidoreductases / Q000096:biosynthesis; D010330:Patents as Topic / Q000706:statistics & numerical data*
chemical_list: D000438:Alcohols; D000588:Amines; D000596:Amino Acids; D002241:Carbohydrates; D004798:Enzymes; D010088:Oxidoreductases; D006867:Hydrolases