New DNA binding ligands as a model of chromomycin A3.
Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this study, new DNA-binding ligands were designed to mimic Chromomycin A(3) (CRA(3)), which contains a hydroxylated tetrahydroanthracene chromophore substituted with di and trisaccharides. The trisaccharide part of CRA(3) that is supposed to contribute to form the Mg(2+)-coordinated dimer was expected to be mimicked by a simple alkyl group attached to the chromophore part as new model compounds. The present study has successfully demonstrated that the new ligands form Mg(2+)-coordinated dimer complexes to exhibit DNA-binding affinity.
Imoto
Shuhei
S
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Haruta
Yoshinari
Y
Watanabe
Kyouichi
K
Sasaki
Shigeki
S
D014128:Chromomycin A3 / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D019281:Dimerization; D008024:Ligands; D008274:Magnesium / Q000378:metabolism
D008024:Ligands; D004247:DNA; D014128:Chromomycin A3; D008274:Magnesium