title: Natural course of asymptomatic pancreatic pseudocyst: a prospective study.
abstract: OBJECTIVE
  To study the natural course of asymptomatic pseudocysts of the pancreas.
  
  
  METHODS
  Thirty patients (age range 18-68 years, mean 44; 24 men) with asymptomatic pseudocysts of the pancreas were enrolled between December 2001 and December 2003, and were followed up every month. Those who developed symptoms due to pseudocyst (increasing pain or features of obstruction such as vomiting or jaundice) were subjected to an endoscopic or surgical drainage procedure. End point of the study was either spontaneous resolution of pseudocyst or drainage procedure.
  
  
  RESULTS
  Eighteen (60%) of 30 patients had resolution of the pseudocyst over an average duration of 5 months. Maximum diameter of less than 7.5 cm and cyst volume less than 250 mL were significantly more frequent in patients with resolution of pseudocyst than in those without (14/18 vs 2/12 [p=0.001] and 15/18 vs 2/12 [p=0.0003], respectively). Presence of internal debris was associated with non-resolution (9/12 vs 2/18; p=0.001).
  
  
  CONCLUSIONS
  Pseudocysts with less than 7.5 cm diameter, volume less than 250 mL, and absence of internal debris were associated with spontaneous resolution within an average duration of 5 months.
authors.affiliation: Department of Gastroenterology, Amrita Institute of Medical Sciences, Amrita Lane, Elamakkara PO, Cochin-682 026, India. rmgastro@yahoo.com
authors.forename: Rajiv
authors.initials: R
authors.lastname: Mehta
authors.forename: Deepak
authors.initials: D
authors.lastname: Suvarna
authors.forename: S
authors.initials: S
authors.lastname: Sadasivan
authors.forename: Anil
authors.initials: A
authors.lastname: John
authors.forename: V
authors.initials: V
authors.lastname: Raj
authors.forename: Prem
authors.initials: P
authors.lastname: Nair
authors.forename: V
authors.initials: V
authors.lastname: Balakrishnan
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde; D018450:Disease Progression; D004322:Drainage / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010186:Pancreatic Function Tests; D010192:Pancreatic Pseudocyst / Q000175:diagnosis* / Q000628:therapy*; D011446:Prospective Studies; D012075:Remission, Spontaneous; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome