title: Quantitative PET cerebral glucose metabolism estimates using a single non-arterialized venous-blood sample.
abstract: The purpose of this study is to develop a method of quantitating the cerebral metabolic rate of glucose (CMRglc) by positron emission tomography using a population-based heated venous curve and one-point sampling from a non-heated vein, i.e. that can avoid arterial puncture.
  
  
  METHODS
  We conducted this study on 17 subjects with a mean age of 61 +/- 9 years. A time-concentration curve as an input function was obtained by sampling 24 blood samples, from the heated left hand vein, one before and the others after intravenous injection of 259 MBq of F-18-fluorodeoxyglucose into the right cubital vein. A non-heated venous sample was also obtained from the right cubital vein.
  
  
  RESULTS
  The population-based input function was calculated by averaging time-concentration curves from the first 7 subjects. A single sample obtained from 10 other subjects from 7.5 to 20 minutes and 35 and 40 minutes after injection predicted input function well with an error of less than 4.5%. The radioactivity in the non-heated 40 minutes' sample was 1.7 +/- 2.9% higher than in the heated vein. When we calibrated the population-based curve using the non-heated venous samples at 40 minutes in 10 subjects, the calculated CMRglc values were 1.3 +/- 5.4% lower than the actual values.
  
  
  CONCLUSIONS
  Non-heated venous one-point sampling and the population-based curve can decrease the complexity of the procedures and the manpower required, and also make the FDG study less invasive, without a significant increase in measurement error.
authors.affiliation: Department of Neurology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan. s-takagi@is.icc.u-tokai.ac.jp
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Takagi
authors.forename: Wakoh
authors.initials: W
authors.lastname: Takahashi
authors.forename: Yukito
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Seiei
authors.initials: S
authors.lastname: Yasuda
authors.forename: Michiru
authors.initials: M
authors.lastname: Ide
authors.forename: Akira
authors.initials: A
authors.lastname: Shohtsu
authors.forename: Takahito
authors.initials: T
authors.lastname: Seio
mesh_terms: D000368:Aged; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011865:Radioisotope Dilution Technique; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014680:Veins / Q000000981:diagnostic imaging / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose