TNF-alpha and homocysteine levels in type 1 diabetes mellitus.
The role of homocysteine as an independent risk factor for vascular endothelial damage, and the possible link between homocysteine and tumour necrosis factor-alpha (TNF-alpha) as two synergistic risk factors for beta-cell apoptosis in type 1 diabetes mellitus was studied. Plasma homocysteine levels were significantly elevated in all diabetic patients compared with controls and diabetic patients with vascular complications showed higher elevations. Furthermore, homocysteine levels showed significant positive correlation with the degree of microalbuminuria. TNF-alpha levels were elevated in all diabetic patients compared with controls. These results may have therapeutic implications.
Abdel Aziz
M T
MT
Department of Medical Biochemistry, Faculty of Medicine, University of Cairo, Cairo, Egypt.
Fouad
H H
HH
Mohsen
G A
GA
Mansour
M
M
Abdel Ghaffar
S
S
D000293:Adolescent; D000419:Albuminuria / Q000209:etiology; D017209:Apoptosis / Q000502:physiology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000209:etiology; D003929:Diabetic Neuropathies / Q000209:etiology; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D002784:Cholesterol; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D006710:Homocysteine; D014409:Tumor Necrosis Factor-alpha