title: Multiple scrotal epidermolytic acanthomas; secondary to trauma?
abstract: Epidermolytic hyperkeratosis (EH) is an abnormality of epidermal maturation, most commonly due to mutations in keratins 1 and 10, which may be a congenital or an acquired defect. The term epidermolytic acanthoma was applied to a solitary discrete epidermal proliferation characterized by EH. Subsequently there have been several reports of disseminated epidermolytic acanthomas. We report a rare case of multiple epidermolytic acanthomas localized to the scrotum. With the aetiology of epidermolytic acanthoma unknown, trauma has been postulated as a possible cause. Our patient repetitively scratched his scrotum for 5 years and we believe that this action triggered his multiple scrotal epidermolytic acanthomas.
authors.affiliation: Department of Dermatology, Oxford Radcliffe Hospitals, Oxford, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Banky
authors.forename: R J
authors.initials: RJ
authors.lastname: Turner
authors.forename: K
authors.initials: K
authors.lastname: Hollowood
mesh_terms: D049309:Acanthoma / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005834:Genital Neoplasms, Male / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000473:pathology; D012611:Scrotum; D012867:Skin / Q000293:injuries