[Whole-body MRI in comparison to skeletal scintigraphy for detection of skeletal metastases in patients with solid tumors].
OBJECTIVE
The aim of this study was to compare the diagnostic efficacy of whole-body magnetic resonance imaging (WB-MRI) as a new and rapid examination technique with skeletal scintigraphy for detection of skeletal metastases from solid tumors.


METHODS
In 129 patients with solid malignant tumors, WB-MRI was performed for individual comparison with skeletal scintigraphy. Examinations were performed with the innovative AngioSURF rolling table with integrated phased array surface coil and coronary TIRM sequences for different body regions.


RESULTS
The results for WB-MRI and skeletal scintigraphy were concordant in 81% of the cases, whereby both procedures excluded skeletal metastases in 43%. WB-MRI and skeletal scintigraphy demonstrated skeletal metastases in 38% of the cases, whereby WB-MRI provided more comprehensive findings in 45%. In 12% of the cases, skeletal scintigraphy was superior to WB-MRI and in 19% the findings were discordant, whereby WB-MRI detected skeletal metastases in 15 cases which had not been found on skeletal scintigraphy. In nine cases, skeletal scintigraphy was positive when the WB-MRI was negative. In 60% of the cases, WB-MRI evidenced tumor-associated findings.


CONCLUSIONS
WB-MRI represents a promising new staging technique for detection of skeletal metastases, which is more sensitive in many cases than skeletal scintigraphy in detecting and assessing the extent of skeletal metastases-and tumor-associated findings that are relevant for treatment strategy.
Ghanem
N
N
Abteilung Röntgendiagnostik, Radiologische Klinik der Albert-Ludwigs-Universität Freiburg. gha@mrs1.ukl.uni-freiburg.de
Kelly
T
T
Altehoefer
C
C
Winterer
J
J
Schäfer
O
O
Bley
T A
TA
Moser
E
E
Langer
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms; D002283:Carcinoma, Bronchogenic; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012509:Sarcoma; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed