title: Circadian phase difference of leptin in android versus gynoid obesity.
abstract: A circadian rhythm in serum leptin, measured every 4 h for 24 h, characterizes normal-weight women (N = 14), and women with gynoid (N = 17) or android (N = 26) obesity, peaking around midnight (P < 0.05), but differing by about 3 h between android and gynoid women (P < 0.01). Obesity is associated with a higher MESOR (rhythm-adjusted mean; P < 0.001) and a smaller relative circadian amplitude (P < 0.05). Gynoid obesity is associated with a larger circadian amplitude of cortisol (P < 0.05), whereas android obesity is associated with a larger circadian amplitude and a higher MESOR of insulin (P < 0.05). Understanding putative mechanisms underlying different body fat distribution may lead to improved chronotherapeutic measures.
authors.affiliation: Department of Internal Medicine, Facoltà di Medicina e Chirurgia, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. perfetto@unifi.it
authors.forename: Federico
authors.initials: F
authors.lastname: Perfetto
authors.forename: Roberto
authors.initials: R
authors.lastname: Tarquini
authors.forename: Germaine
authors.initials: G
authors.lastname: Cornélissen
authors.forename: Giorgio
authors.initials: G
authors.lastname: Mello
authors.forename: Alessio
authors.initials: A
authors.lastname: Tempestini
authors.forename: Paola
authors.initials: P
authors.lastname: Gaudiano
authors.forename: Francesco
authors.initials: F
authors.lastname: Mancuso
authors.forename: Franz
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000145:classification / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D007328:Insulin; D020738:Leptin; D006854:Hydrocortisone