title: [Clinical outcomes of women with transfusion-associated hepatitis C after 10-15 years follow-up].
abstract: BACKGROUND
  To investigate natural history of hepatitis C virus (HCV) infection and related factors in China.
  
  
  METHODS
  Totally 41 women infected with HCV 10-15 years ago were evaluated in this study. Their clinical manifestations were recorded and sera tested for alamine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), total protein (TP), albumin (ALB), and alpha-fetoprotein (alpha-FP), as well as virus markers. The B-type ultrasound examination was performed on the liver, gall bladder, spleen and pancreas. For virus markers, HCV RNA was detected with fluorogenic-quantitative polymerase-chain-reaction, HBsAg and anti-HCV antibody, with enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Ten to 15 years after infection, the infection was cleared spontaneously in 8 cases (19.51%); 73%(30/41) cases had signs at present, 32% (13/41) cases had mild ALT and/or AST elevation. On ultrasound examination, 83%(34/41) had mild degree 17%(7/41) moderate degree changes of the viral hepatitis.
  
  
  CONCLUSIONS
  Women with HCV infection for 13 +/- 1 (10-15) years after transfusion had slight hepatic inflammation. A part of them had cleared the virus spontaneously.
authors.affiliation: Hepatology Institute, Peking University Peoples Hospital, Beijing 100044, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Guo
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.forename: Qi-xin
authors.initials: QX
authors.lastname: Wang
authors.forename: De-gui
authors.initials: DG
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Ji
authors.forename: Xu
authors.initials: X
authors.lastname: Cong
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Lai
authors.initials: L
authors.lastname: Wei
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000635:transmission*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D065227:Transfusion Reaction
chemical_list: D012367:RNA, Viral