K103N mutation in antiretroviral therapy-naive African patients infected with HIV type 1.
Most of the information about genetic sequencing and drug susceptibility of human immunodeficiency virus type 1 (HIV-1) is derived from the study of HIV-1 subtype B. Worldwide, most people infected with HIV-1 are infected with non-subtype B viruses and live in developing countries. We report 3 cases of antiretroviral-naive African immigrants infected with HIV-1 strains possessing the K103N mutation in the reverse transcriptase gene, which confers high-level resistance to all nonnucleoside reverse transcriptase inhibitors.
Akinsete
Omobosola
O
Department of Infectious Diseases, University of Minnesota/Hennepin County Medical Center, Minneapolis, Minnesota 55455, USA. BosolaA@aol.com
Hirigoyen
Diane
D
Cartwright
Charles
C
Schut
Ron
R
Kantor
Rami
R
Henry
Keith
K
D019943:Amino Acid Substitution / Q000235:genetics; D023241:Antiretroviral Therapy, Highly Active / Q000639:trends; D001216:Asparagine / Q000235:genetics* / Q000502:physiology; D024882:Drug Resistance, Viral / Q000235:genetics* / Q000502:physiology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008239:Lysine / Q000235:genetics* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense / Q000235:genetics*; D012194:RNA-Directed DNA Polymerase / Q000235:genetics / Q000502:physiology; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins; D001216:Asparagine; D012194:RNA-Directed DNA Polymerase; D008239:Lysine