title: [Effect of Baisuifang Granule on cognitive malfunction after cerebral infarction].
abstract: OBJECTIVE
  To explore the mechanism of Baisuifang Granule in treating cognitive malfunction after cerebral infarction.
  
  
  METHODS
  One hundred and sixty patients with cerebral infarction were divided randomly into two groups. Eighty patients were treated with Baisuifang Granule and 80 with nimodipine for two months. Clinical observation and laboratory examinations were performed for Mini-Mental State Examination (MMSE), clinical symptoms, Chinese Stroke Scale (CSS), hemorrheological indexes and fibrinogen before and after the treatment.
  
  
  RESULTS
  Baisuifang Granule could improve MMSE, reduce the scores of clinical symptoms and CSS, and meliorate the blood rheology. The total effective rate for clinical symptoms in the Baisuifang treated group accounted to 76.25%, with statistical difference comparing to 58.75% of nimodipine treated group (P<0.05). There was significant difference in symptom integral, CSS and whole blood viscosity at the high shear rate, respectively (P<0.01).
  
  
  CONCLUSIONS
  Baisuifang Granule is an effective Chinese medicine for treating cognitive malfunction after cerebral infarction.
authors.affiliation: Department of Traditional Chinese Medicine, RuiJin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zheng
authors.forename: Xiao-Heng
authors.initials: XH
authors.lastname: Shen
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhai
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Tang
authors.forename: Chan-Xing
authors.initials: CX
authors.lastname: Yuan
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Xia
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001809:Blood Viscosity / Q000187:drug effects; D002544:Cerebral Infarction / Q000150:complications*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000627:therapeutic use; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D009553:Nimodipine