title: Ophthalmic artery occlusion secondary to radiation-induced vasculopathy.
abstract: A 35-year-old man with neurofibromatosis type 1 (NF1) had a left ophthalmic artery occlusion that caused no light perception OS 28 years after having been treated with external beam radiation therapy for a presumed glioma of the right optic nerve and chiasm. Clinical and imaging findings were consistent with radiation-induced cerebral vasculopathy. This ophthalmic complication has never been reported, despite the common occurrence of severe carotid-ophthalmic artery junction stenosis after radiation in NF1 patients. Even though modern radiation techniques limit collateral damage, this modality should be used with discretion in NF1 patients, given the vulnerability of their immature cerebral vasculature to radiation.
authors.affiliation: Department of Ophthalmology, Kellogg Eye Center, University of Michigan Medical Center, 1000 Wall Street, Ann Arbor, MI 48105, USA.
authors.forename: Rita
authors.initials: R
authors.lastname: Singh
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Trobe
authors.forename: James A
authors.initials: JA
authors.lastname: Hayman
authors.forename: John P
authors.initials: JP
authors.lastname: Deveikis
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000209:etiology*; D001766:Blindness / Q000209:etiology*; D002533:Cerebral Angiography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009456:Neurofibromatosis 1 / Q000473:pathology / Q000532:radiotherapy; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000528:radiation effects*; D009897:Optic Chiasm / Q000473:pathology / Q000528:radiation effects; D020339:Optic Nerve Glioma / Q000473:pathology / Q000532:radiotherapy; D019574:Optic Nerve Neoplasms / Q000473:pathology / Q000532:radiotherapy; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D014792:Visual Acuity