Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase.
The synthesis and nNOS and eNOS activity of 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-2,5-dimethoxyphenyl)-pyridin-2-ylamines 1-8 are described. These compounds are potent inhibitors of the human nNOS isoform.
Nason
Deane M
DM
Pfizer Global Research and Development, Groton, CT 06340, USA.
Heck
Steven D
SD
Bodenstein
Mathew S
MS
Lowe
John A
JA
Nelson
Robert B
RB
Liston
Dane R
DR
Nolan
Charles E
CE
Lanyon
Lorraine F
LF
Ward
Karen M
KM
Volkmann
Robert A
RA
D000588:Amines / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors*; D009433:Neural Inhibition / Q000187:drug effects; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology
D000588:Amines; D004791:Enzyme Inhibitors; D009419:Nerve Tissue Proteins; D011725:Pyridines; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I