Increased CXCL8 (IL-8) expression in Multiple Sclerosis.
Multiple Sclerosis (MS) is a chronic inflammatory disease of the CNS which is characterized by large mononuclear cell infiltration and significant demyelination. CXCL8 is a chemo-attractant for both neutrophils and monocytes and triggers their firm adhesion to endothelium. In this study, we demonstrate that serum CXCL8 and CXCL8 secretion from PBMCs are significantly higher in untreated MS patients compared to controls and are significantly reduced in MS patients receiving interferon-beta1a therapy. We suggest that CXCL8 may serve as a marker of monocyte activity in MS and may play a role in monocyte recruitment to the CNS.
Lund
Brett T
BT
Department of Neurology, Keck School of Medicine, University of Southern California, MCH-142, Los Angeles, California 90033, USA. blund@usc.edu
Ashikian
Nazely
N
Ta
Huy Q
HQ
Chakryan
Yervand
Y
Manoukian
Krikor
K
Groshen
Susan
S
Gilmore
Wendy
W
Cheema
Gurtej S
GS
Stohl
William
W
Burnett
Margaret E
ME
Ko
David
D
Kachuck
Norman J
NJ
Weiner
Leslie P
LP
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002490:Central Nervous System / Q000276:immunology / Q000503:physiopathology; D019743:Chemokines, CXC / Q000097:blood* / Q000276:immunology* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000187:drug effects / Q000276:immunology*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000276:immunology* / Q000378:metabolism; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D009103:Multiple Sclerosis / Q000097:blood* / Q000188:drug therapy / Q000276:immunology*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D011237:Predictive Value of Tests; D015854:Up-Regulation / Q000187:drug effects / Q000276:immunology
D015415:Biomarkers; D019743:Chemokines, CXC; D036341:Intercellular Signaling Peptides and Proteins; D016899:Interferon-beta; D000068556:Interferon beta-1a