Approaches to imprinted stationary phases for affinity capillary electrochromatography.
The combination of two highly attractive technologies in analytical chemistry, namely molecular imprinting and capillary electrochromatography, is reviewed. Molecular imprinting represents an approach to incorporate affinity binding sites for one or a class of target molecules in network polymers whereas capillary electrochromatography is a technique that profits from the high separation efficiency of electrodriven separations and the high selectivity and capacity available with liquid chromatography. The review discusses and compares the various approaches taken, to combine these concepts aiming at robust, reproducible and easily available capillary-based affinity separation media.
Quaglia
Milena
M
Department of Pharmaceutical Chemistry, Viale Taramelli 12, University of Pavia, 27100 Pavia, Italy.
Sellergren
Börje
B
De Lorenzi
Ersilia
E
D020374:Chromatography, Micellar Electrokinetic Capillary / Q000295:instrumentation* / Q000379:methods; D008855:Microscopy, Electron, Scanning; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity