title: Jumping in before the water is hot: the need to support randomized controlled clinical trials.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Epstein
mesh_terms: D000368:Aged; D017147:Defibrillators, Implantable / Q000706:statistics & numerical data*; D019544:Equipment Failure Analysis / Q000379:methods; D019317:Evidence-Based Medicine / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000401:mortality* / Q000628:therapy*; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods; D010138:Pacemaker, Artificial / Q000706:statistics & numerical data; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013534:Survival; D016019:Survival Analysis; D013673:Technology Assessment, Biomedical / Q000379:methods; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000401:mortality* / Q000628:therapy*