Effect of the synthetic polyamine N,N'-bis-(3-aminopropyl) cyclohexane-1,4-diamine (DCD) on rat spinal cord nociceptive transmission.
In rats submitted to a C-fiber reflex response paradigm, intravenous (i.v.) administration of 2.5, 5 and 10 mg/kg of the synthetic polyamine N,N'-bis-(3-aminopropyl) cyclohexane-1,4-diamine (DCD) dose-dependently reduced both the integrated C reflex responses and wind-up activity. Inhibitory effects of the polyamine on spinal cord nociceptive transmission are likely to be consequence of blockade by extracellular DCD of NMDA receptor channels localized in dorsal horn neurons, although modulatory actions at supraspinal level and at other ion channels could also be possible.
Bilbeny
Norberto
N
Garbil Pharma Investigación Chile, Room 402, Ave. Los Leones 382, Santiago, Chile. nbilbeny@ctcinternet.cl
Paeile
Carlos
C
Contreras
Selfa
S
Font
María
M
García
Hernán
H
D000818:Animals; D003510:Cyclohexanes / Q000008:administration & dosage / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D009474:Neurons / Q000187:drug effects; D009619:Nociceptors / Q000502:physiology*; D010147:Pain Measurement / Q000379:methods; D011073:Polyamines / Q000008:administration & dosage / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D003510:Cyclohexanes; C508894:N,N'-bis-(3-aminopropyl) cyclohexane-1,4-diamine; D011073:Polyamines