Adipose tissue expression of IL-18 and HIV-associated lipodystrophy.
IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.
Lindegaard
Birgitte
B
Department of Infectious Diseases, University of Copenhagen, Copenhagen, Denmark.
Hansen
Ann-Brit Eg
AB
Pilegaard
Henriette
H
Keller
Pernille
P
Gerstoft
Jan
J
Pedersen
Bente Klarlund
BK
D000273:Adipose Tissue / Q000378:metabolism*; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D039682:HIV-Associated Lipodystrophy Syndrome / Q000378:metabolism*; D006801:Humans; D020382:Interleukin-18 / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D020382:Interleukin-18; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha