Efficacy of albendazole in giardiasis.
Albendazole and metronidazole were compared in 68 patients diagnosed positive for giardiasis. Albendazole 1200 mg, one dose was given to 24 patients, albendazole 400 mg twice a day for 3 days was given to 23 patients, and metronidazole 400 mg 3 times a day for 5 days to 21 patients. Response to therapy was monitored by clinical examination and analysis of fresh faecal samples on days 0, 3, 7 and 10. Response to the single dose of albendazole was 55%, to the divided dose of albendazole 70%, and to metronidazole 84%. The results show that albendazole, originally recommended for helminthic infection, can also be used in patients with mixed protozoal infection or for infections resistant to metronidazole.
Baqai
R
R
Pakistan Medical Research Council Research Centre, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
Zuberi
S J
SJ
Qureshi
H
H
Ahmed
W
W
Hafiz
S
S
D015746:Abdominal Pain / Q000469:parasitology; D000293:Adolescent; D000328:Adult; D000368:Aged; D015766:Albendazole / Q000494:pharmacology / Q000627:therapeutic use*; D000855:Anorexia / Q000469:parasitology; D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003967:Diarrhea / Q000469:parasitology; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005243:Feces / Q000469:parasitology; D005260:Female; D005414:Flatulence / Q000469:parasitology; D005873:Giardiasis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009325:Nausea / Q000469:parasitology; D010154:Pakistan / Q000453:epidemiology; D010270:Parasite Egg Count; D016896:Treatment Outcome; D014839:Vomiting / Q000469:parasitology
D000981:Antiprotozoal Agents; D008795:Metronidazole; D015766:Albendazole