title: Cholesterol-lowering with statins: are they all the same? Summary of the expert symposium at the 53rd Annual Scientific Sessions of the American College of Cardiology.
abstract: Since they share a common mode of action and certain structural features, all statins exhibit the same broad pharmacological effects. Nevertheless, important differences exist between the statins in terms of LDL cholesterol-lowering, endpoint reduction, pleiotropic effects and toxicity. For this reason, it is incorrect to view all statins as being interchangeable as lipid-lowering therapy. In addition, it should be remembered that perhaps the main difficulty in clinical practice today does not concern details of the differences between statins but rather the fact that in many studies long-term compliance has been shown to be only around 30%.
mesh_terms: D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy*; D012955:Societies, Medical; D014481:United States
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors