[Intensive effect of traditional Chinese medicines activating blood to resolve stasis on medicines dredging intestines--influence on peristalsis of small intestine in guinea pigs].
OBJECTIVE
To observe the changes of peristalsis of small intestine in guinea pigs after administration of traditional Chinese medicines activating blood to resolve stasis (Compound Danshen Decoction, CDSD) or/and medicines dredging intestines (Dachengqi Decoction, DCQD), and to explore the synergetic or intensive effect of CDSD on DCQD.


METHODS
By means of BL-420 Biological Experimental System, peristalsis of small intestine was recorded and analyzed following administration of DCQD, CDSD or Huoxue Chengqi Decoction (HXCQD, compound of CDSD and DCQD) respectively in different experimental periods.


RESULTS
The amplitude and frequency of intestinal peristaltic wave obviously increased following administration of the three decoctions, but HXCQD appeared to be most dominantly.


CONCLUSIONS
The effect of DCQD can be further enhanced by combining use of CDSD, suggesting that the traditional Chinese medicines activating blood to resolve stasis have an intensive effect on medicines dredging intestines.
Yang
Tao
T
Tianjin Reseach Institute of Acute Abdominal Diseases, Tianjin 300100, China.
Wu
Xian-Zhong
XZ
Guo
Shi-Duo
SD
Li
Dong-Hua
DH
Wang
Yu-Yun
YY
D000818:Animals; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D018589:Gastroparesis / Q000188:drug therapy*; D006168:Guinea Pigs; D007421:Intestine, Small / Q000187:drug effects; D008297:Male; D008516:Medicine, Chinese Traditional; D023421:Models, Animal; D009130:Muscle, Smooth / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D011897:Random Allocation; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts