Update on management of intracerebral hemorrhage.
Intracerebral hemorrhage (ICH) is a lingering cause of significant mortality and morbidity rates in contemporary society. Despite its established burden, considerably less investigative attention has been devoted to the study of ICH than other forms of stroke. Only a limited number of clinical studies have been performed to examine the surgical (both craniotomy and minimally invasive) and medical management of patients with ICH. No consistently efficacious strategies have been identified through such investigations. Limitations in study design and execution have universally impaired the interpretation and impact of available data. Management of ICH unfortunately remains heterogeneous across institutions, and it continues to suffer from the lack of proven medical and surgical effectiveness. Urgently needed are further prospective randomized controlled trials in which investigators consider the shortcomings of previous endeavors in the management of ICH. In the present article the authors review the current management practices of ICH, discuss the controlled trials, and highlight recent trials and future avenues of further study.
Pouratian
Nader
N
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA. np5k@virginia.edu
Kassell
Neal F
NF
Dumont
Aaron S
AS
D000959:Antihypertensive Agents / Q000627:therapeutic use; D019090:Case Management; D002543:Cerebral Hemorrhage / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D003128:Coma / Q000209:etiology; D003399:Craniotomy; D004724:Endoscopy; D005440:Fluid Therapy; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D019586:Intracranial Hypertension / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D008991:Monitoring, Physiologic; D015337:Multicenter Studies as Topic; D011183:Postoperative Complications; D016032:Randomized Controlled Trials as Topic; D017131:Thrombectomy
D000959:Antihypertensive Agents