Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.
The family of cyclin-dependent kinases (Cdks) lies at the core of the machinery that drives the cell division cycle. Studies in cultured mammalian cells have provided insight into the cellular functions of many Cdks. Recent Cdk and cyclin knockouts in the mouse show that the functions of G1 cell cycle regulatory genes are often essential only in specific cell types, pointing to our limited understanding of tissue-specific expression, redundancy, and compensating mechanisms in the Cdk network.
Pagano
Michele
M
Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. michele.pagano@med.nyu.edu
Jackson
Peter K
PK
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D018844:Cyclin-Dependent Kinases / Q000235:genetics*; D016213:Cyclins / Q000235:genetics; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D016193:G1 Phase / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D018816:Genes, cdc / Q000502:physiology*; D051379:Mice; D038081:Organogenesis / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
D016213:Cyclins; D018844:Cyclin-Dependent Kinases