title: Prevention of de novo adhesion by ferric hyaluronate gel after laparoscopic surgery in an animal model.
abstract: OBJECTIVE
  Adhesions remain a major cause of severe long-term complications. Attempts have been made to prevent adhesion formation by using endogenous or exogenous materials with controversial results. Our aim was to evaluate the efficacy of 0.5% ferric hyaluronate gel in the prevention of adhesion formation after laparoscopic surgery.
  
  
  METHODS
  This was a prospective, randomized, experimental study (animal model). The study population comprised 75 female rabbits (Fauve de Bourgogne) weighing over 3 kg. The rabbits were randomized into 3 groups of 25 (hyaluronate, saline, and control) by using a predetermined computer-generated randomization code. All rabbits underwent a peritoneal laparoscopic resection, and the main outcome measure was the adhesion formation after laparoscopic surgery.
  
  
  RESULTS
  The laparoscopic operating time and the mean interval before second-look surgery were not different among the 3 groups. The number of rabbits with adhesions did not differ among the 3 groups. The bowel adhesion rate was higher at the 10-mm trocar site than at the 5-mm trocar site (P=0.01). The adhesion scores did not differ among the 3 groups. A strong correlation was found between the values of the different adhesion scoring systems used.
  
  
  CONCLUSIONS
  These results obtained in a rabbit model suggest that routine intraperitoneal application of hyaluronate gel does not prevent adhesion formation after laparoscopic surgery.
authors.affiliation: Service de Gynécologie, Hôpital Hôtel-Dieu de Paris, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Detchev
authors.forename: Marc
authors.initials: M
authors.lastname: Bazot
authors.forename: David
authors.initials: D
authors.lastname: Soriano
authors.forename: Emile
authors.initials: E
authors.lastname: Daraï
mesh_terms: D000818:Animals; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage*; D005782:Gels; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D010535:Laparoscopy; D010529:Peritoneal Cavity; D011817:Rabbits; D011897:Random Allocation; D012965:Sodium Chloride / Q000008:administration & dosage; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D005290:Ferric Compounds; D005782:Gels; D012965:Sodium Chloride; D006820:Hyaluronic Acid