Interleukin-1 gene cluster polymorphisms and risk of Alzheimer's disease in Chinese Han population.
Interleukin-1 (IL-1) has been implicated as a key cytokine in Alzheimer's disease (AD) pathogenesis. IL-1 gene polymorphisms, especially IL-1A C((-)889)T polymorphism, have been suggested to be associated with AD risk and onset age. To determine if IL-1 polymorphisms are genetic risk factors for developing AD in Chinese Mainland population, we analyzed IL-1A ((-)889), IL-1B ((-)511) and IL-1RN variable number of tandem repeat (VNTR) polymorphisms in a sample of 145 sporadic AD patients and 181 healthy controls. Our data revealed that the three polymorphisms in IL-1 gene cluster might not play a key role in AD pathogenesis in Chinese Mainland Han population.
Li
X-Q
XQ
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing, P.R. China.
Zhang
J-W
JW
Zhang
Z-X
ZX
Chen
D
D
Qu
Q-M
QM
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D005810:Multigene Family / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D017472:Receptors, Interleukin-1 / Q000235:genetics; D020080:Tandem Repeat Sequences / Q000235:genetics
D007375:Interleukin-1; D017472:Receptors, Interleukin-1