title: [Applied study on small-dose growth hormone supplement for aging-related symptom complex].
abstract: OBJECTIVE
  To assess the response of aging-related symptom complex to small-dose supplement of growth hormone.
  
  
  METHODS
  Thirty patients, aged 42 to 77, with aging-related symptom complex and normal serum testosterone were studied. Each subject received growth hormone at the dosage of 0.04 U/kg, 3 times/week for six months. Before and after treatment, body weight, grip strength, abdomen circumference, IPSS, uroflow rate, prostate volume, serum testosterone, cholesterol, triglyceride, PSA, IGF-1, glucose and side effects were determined in every case. Self Rating Scale used by Bosphorus university was adopted.
  
  
  RESULTS
  After the treatment, the rating scores were significantly improved, grip strength and serum level of IGF-1 increased, and abdomen circumference and serum cholesterol decreased. Whereas, IPSS, uroflow rate, prostate volume, serum testosterone, triglyceride, PSA, glucose and body weight were not significantly changed.
  
  
  CONCLUSIONS
  Six months treatment with small-dose growth hormone can improve aging-related symptom complex with little adverse effect.
authors.affiliation: Department of Urology, Affiliated Renji Hospital of Shanghai Second Medical University, Shanghai Institute of Andrology, Shanghai 200001, China. xiansheng-zhang@163.com
authors.forename: Xiansheng
authors.initials: X
authors.lastname: Zhang
authors.forename: Yixin
authors.initials: Y
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Leng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Bai
authors.forename: Xuyuan
authors.initials: X
authors.lastname: Huang
authors.forename: Yiran
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D019588:Aging, Premature / Q000188:drug therapy*; D047649:Andropause; D001786:Blood Glucose / Q000378:metabolism; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood
chemical_list: D001786:Blood Glucose; D008055:Lipids; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D017430:Prostate-Specific Antigen