title: Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids.
abstract: A series of indole alkaloids of the ibogan-type was assessed for their cytotoxic effects as well as their potential in reversing MDR in vincristine-resistant KB cells. Of a total of 25 compounds tested, 3(S)-cyanocoronaridine, 3(S)-cyanoisovoacangine, 3(S)-cyanovoacangine, and 10,11-demethoxychippiine were found to show appreciable cytotoxicity toward KB cells, while coronaridine, heyneanine, 19-epi-heyneanine, dippinine B, and dippinine C, were found to reverse MDR in vincristine-resistant KB cells.
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. tskam@um.edu.my
authors.forename: Toh-Seok
authors.initials: TS
authors.lastname: Kam
authors.forename: Kooi-Mow
authors.initials: KM
authors.lastname: Sim
authors.forename: Huey-Shen
authors.initials: HS
authors.lastname: Pang
authors.forename: Takashi
authors.initials: T
authors.lastname: Koyano
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hayashi
authors.forename: Kanki
authors.initials: K
authors.lastname: Komiyama
mesh_terms: D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000633:toxicity*; D026121:Indole Alkaloids / Q000633:toxicity*
chemical_list: D026121:Indole Alkaloids; D007050:Ibogaine