title: Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species.
abstract: Eight new dimeric bromopyrrole alkaloids, nagelamides A-H (1-8) and a monomeric one, 9,10-dihydrokeramadine (9), have been isolated from the Okinawan marine sponge Agelas sp., and the structures were elucidated from spectroscopic data. Nagelamides A-H (1-8) exhibited antibacterial activity against Gram-positive bacteria. Nagelamide G (7) inhibited protein phosphatase 2A activity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Endo
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okada
authors.forename: Shinya
authors.initials: S
authors.lastname: Mitsuhashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shima
authors.forename: Kunimi
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Mikami
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D011161:Porifera / Q000737:chemistry*; D054648:Protein Phosphatase 2; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D006842:Hydrocarbons, Brominated; D011758:Pyrroles; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2