title: New resorbable polymeric systems with antithrombogenic activity.
abstract: The synthesis and application as resorbable coatings of vascular grafts of a new polyacrylic derivative of Triflusal (2-acetyloxy-4-trifluoromethyl)benzoic acid, a commercial drug with antithrombogenic properties, are described. The high-molecular-weight polyacrylic system is rather stable in physiological conditions and provides a chemical support for the slow release of the pharmacologically active compound, Triflusal, or its main metabolite (2-hydroxy-4-trifluoromethyl)benzoic acid (HTB). Experiments of deposition and retention of platelets in static basal conditions using plasma-rich medium from blood of sheep, seem to indicate that the polymeric coating of the polyacrylic derivative of Triflusal improves the antiaggregating character for platelets of the surface of small-diameter vascular grafts without the application of other antithrombogenic drugs.
authors.affiliation: Instituto de Ciencia y Tecnología de Polímeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Gallardo
authors.forename: J
authors.initials: J
authors.lastname: San Román
authors.forename: M
authors.initials: M
authors.lastname: Rebuelta
authors.forename: P
authors.initials: P
authors.lastname: Bermejo
authors.forename: J
authors.initials: J
authors.lastname: Buján
authors.forename: J M
authors.initials: JM
authors.lastname: Bellón
authors.forename: N G
authors.initials: NG
authors.lastname: Honduvilla
authors.forename: C
authors.initials: C
authors.lastname: Escudero