[The protein arrestin as a regulator of the phototransduction process and as a factor of pathogenesis of the eye diseases].
In the first part of the paper, the results of the investigation of the rhodopsin arrestin interaction are presented. The results were mainly obtained with the technique of the selective labelling of the rhodopsin and arrestin SH-groups and the rhodopsin limited proteolysis. These results are discussed in the frame of the latest data on the three-dimensional structure of arrestin. In the second part of the paper, results of the antigenic properties of arrestin (S-antigen) and its role in the pathogenesis of the retina diseases are summarized. The data on the role of the autoimmune processes in the pathogenesis of diabetic retinopathy are presented. We have also described the results of the use of the elaborated technique of the immune diagnostics in the prognosis of the diabetic retinopathy and retinopathy of the premature babies.
Kalamkarov
G R
GR
Ostrovskiĭ
M A
MA
D000818:Animals; D019393:Arrestin / Q000276:immunology / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D005128:Eye Diseases; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011485:Protein Binding; D012164:Retinal Diseases / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D012243:Rhodopsin / Q000378:metabolism*; D014785:Vision, Ocular / Q000502:physiology*
D019393:Arrestin; D012243:Rhodopsin