Parallel ligand screening on olefin mixtures in asymmetric hydroformylation reactions.
[reaction: see text] Herein we describe a new protocol for catalyst evaluation in asymmetric hydroformylation reactions where multisubstrate screening is performed in an array of parallel reactors. This method was successfully demonstrated using a mixture of styrene, allyl cyanide, and vinyl acetate. Using this screening methodology, a set of phosphite ligands was evaluated and led to the discovery of a bisphosphite ligand that gave 88% ee and unprecedented >100:1 branched:linear regioselectivity in asymmetric hydroformylation of vinyl acetate.
Cobley
Christopher J
CJ
Chemical Sciences, The Dow Chemical Company, 1776 Building, Midland, Michigan 48674, USA.
Klosin
Jerzy
J
Qin
Cheng
C
Whiteker
Gregory T
GT