1-Phenyl-3-toluyl-4-[ortho-1'-(N-ethyl-2'-methylpropylamine)]phenylpyrazole, synthesis and evaluation of the in vitro antifungal activity against Botrytis cinerea and Fusarium oxysporum.
A novel antifungal pyrazole derivative was synthesized. Designated 1-phenyl-3-toluyl-4-[ortho-1'-(N-ethyl-2'-methylpropylamine)]phenylpyrazole, the compound exerted an antifungal effect toward Botrytis cinerea and Fusarium oxysporum. In fact, our results clearly show that mycelial growth and conidial germination of both fungi were blocked by the compound. Indeed, a 96-well microbioassay procedure was used for fast and easy evaluation of minimal inhibitory concentration (MIC). The MIC values for B. cinerea and F. oxysporum were 25 and 36 microg/ml, respectively.
Dardari
Zainaba
Z
Laboratoire de Microbiologie et Biologie Moléculaire, Département de Biologie, Faculté des Sciences Ben M'sik-Casablanca, Université Hassan II-Mohammedia, Casablanca BP 7955, Morocco. dzainaba@yahoo.fr
Boudouma
Mohammed
M
Sebban
Abdelfatah
A
Bahloul
Abdelmejid
A
Kitane
Said
S
Berrada
Mohamed
M
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D020171:Botrytis / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005670:Fusarium / Q000187:drug effects* / Q000254:growth & development; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D011720:Pyrazoles