title: Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein.
abstract: Zona pellucida (ZP) domain has been recognized in a number of receptor-like eukaryotic glycoproteins, which involved in many important biological processes, such as signal transduction, development, differentiation and so on. Here we report the identification of Mus musculus and Rattus norvegicus orthologues of Homo sapiens LZP gene which codes for a novel ZP domain-containing protein. Sequence analysis revealed that human, rat and mouse LZP proteins are highly conserved. Mouse LZP gene has two transcripts, 2.4 and 2.8 KB long respectively, coding for identical protein. Mouse LZP mRNA is expressed specifically in hepatocytes. Our data also showed that mouse LZP localizes mostly on nuclear envelope, and at the same time, it can be secreted into blood in a truncated form.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 220 Han Dan Road, Shanghai, 200433, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Xu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Du
authors.forename: Shu-Jian
authors.initials: SJ
authors.lastname: Cui
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Ke-Ke
authors.initials: KK
authors.lastname: Huo
authors.forename: Yu-Yang
authors.initials: YY
authors.lastname: Li
authors.forename: Ze-Guang
authors.initials: ZG
authors.lastname: Han
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000032:analysis / Q000235:genetics; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013347:Subcellular Fractions; D015044:Zona Pellucida
chemical_list: D018076:DNA, Complementary; C492692:LZP protein, mouse; D008565:Membrane Proteins; C477697:OIT3 protein, human; C492693:Oit3 protein, rat