title: Development of mucoadhesive patches for buccal administration of ibuprofen.
abstract: A new formulation for topical administration of drugs in the oral cavity has been developed using several film-forming and mucoadhesive polymers. The films have been evaluated in terms of swelling, mucoadhesion and organoleptic characteristics. The best film, containing polyvinylpyrrolidone (PVP) as film-forming polymer and carboxymethylcellulose sodium salt (NaCMC) as mucoadhesive polymer, was loaded with ibuprofen as a model compound and in vitro and in vivo release studies were performed. Statistical investigation of in vitro release revealed that the diffusion process was the main drug release mechanism and the Higuchi's model provided the best fit. In vivo studies showed the presence of ibuprofen in saliva (range 70-210 microg/ml) for 5 h and no irritation was observed. These mucoadhesive formulations offer many advantages in comparison to traditional treatments and can be proposed as a new therapeutic tool against dental and buccal diseases and disturbs.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Via del Liceo, 1, 06123 Perugia, Italy. luanaper@unipg.it
authors.forename: Luana
authors.initials: L
authors.lastname: Perioli
authors.forename: Valeria
authors.initials: V
authors.lastname: Ambrogi
authors.forename: Fausta
authors.initials: F
authors.lastname: Angelici
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ricci
authors.forename: Stefano
authors.initials: S
authors.lastname: Giovagnoli
authors.forename: Marinella
authors.initials: M
authors.lastname: Capuccella
authors.forename: Carlo
authors.initials: C
authors.lastname: Rossi
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000268:Adhesiveness; D000278:Administration, Buccal; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D011205:Povidone / Q000737:chemistry
chemical_list: D000179:Acrylates; D018712:Analgesics, Non-Narcotic; D003692:Delayed-Action Preparations; C477020:Eudragit E100; C496967:Eudragit NE40D; C496966:Eudragit RSPO; D011108:Polymers; D011109:Polymethacrylic Acids; D011205:Povidone; D002266:Carboxymethylcellulose Sodium; D007052:Ibuprofen