Bony syngnathia, vertebral segmentation defect, coloboma, microcephaly and mental retardation: confirmation of Dobrow syndrome and review of syndromal syngnathias.
Congenital bony fusion of the maxilla and mandible is a rare condition. Two classifications were previously proposed dealing exclusively with craniofacial malformations. Most of the reported cases to date represent either aglossia-adactylia or hemifacial microsomia syndromes. We report a young girl with bony syngnathia associated with multiple defects (severe microcephaly, coloboma, vertebral segmentation defects), growth and mental delay. This patient is very similar to the patient described by Dobrow in 1983 and confirms the existence of this extremely rare disorder.
Verloes
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Clinical Genetic Unit INSERM E9935, Hôpital Robert Debré, Paris, France Department of Pediatric Surgery Neonatology Neuropediatrics Radiology, Hôpital La Citadelle, Liège, Belgium ENT Plastic Surgery Departments, Cliniques Universitaires Saint Luc, Brussels, Belgium.
Raoul
M
M
Genevieve
D
D
Sznajer
Y
Y
Demarche
M
M
Lombet
J
J
Rigo
V
V
Misson
J P
JP
Collignon
L
L
Vanwijck
F
F
Vanwijck
R
R
D003103:Coloboma / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000503:physiopathology*; D008334:Mandible / Q000002:abnormalities* / Q000000981:diagnostic imaging; D008437:Maxilla / Q000002:abnormalities* / Q000000981:diagnostic imaging; D008831:Microcephaly / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011859:Radiography; D012886:Skull / Q000002:abnormalities / Q000000981:diagnostic imaging; D013131:Spine / Q000002:abnormalities*