TOR pathway: linking nutrient sensing to life span.
Recent studies point to an emerging role for the TOR (target of rapamycin) pathway in the regulation of life span. In this Perspective, we discuss the possibility that this pathway is an important modulator of nutrient-dependent changes in life span. Additionally, we discuss the interactions between the TOR and insulin-like signaling pathways as well as the key downstream processes that TOR regulates.
Kapahi
Pankaj
P
Buck Institute for Age Research, Novato, CA 94945, USA. Pkapahi@buckinstitute.org
Zid
Brian
B
D000818:Animals; D006801:Humans; D008136:Longevity / Q000502:physiology*; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism* / Q000502:physiology; D058570:TOR Serine-Threonine Kinases
D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases