title: Determination of sensitive positions to mutations in human p53 protein.
abstract: Over last several years, we demonstrated that the mutations are more likely to occur at randomly unpredictable amino acid pairs in a protein. We therefore can in principle predict the amino acid pairs sensitive to the future mutations in a protein. However, we still need to predict the positions at which the sensitive amino acid pairs are located in a protein. In this study, we use a probabilistic approach to analyze the effect of 191 mutations in human p53 protein and can approximately estimate the sensitive positions to mutations in human p53 protein.
authors.affiliation: Computational Mutagen Project, DreamSciTech Consulting Co. Ltd., 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province, CN-518054, China. hongguanglishibahao@yahoo.com
authors.forename: Guang
authors.initials: G
authors.lastname: Wu
authors.forename: Shaomin
authors.initials: S
authors.lastname: Yan
mesh_terms: D006801:Humans; D016296:Mutagenesis / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D011336:Probability; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry* / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53