An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population.
We performed an association study between three SNPs in the genes of 14-3-3 family and paranoid schizophrenia. SNP rs983583 G/A in the YWHAZ gene showed significant association with paranoid schizophrenia. Our study indicated that the YWHAZ gene was a potential susceptibility gene for paranoid schizophrenia in the population studied.
Jia
Yanbin
Y
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Yu
Xin
X
Zhang
Boyu
B
Yuan
Yanbo
Y
Xu
Qi
Q
Shen
Yucun
Y
Shen
Yan
Y
D000328:Adult; D002681:China; D017931:DNA Primers / Q000235:genetics; D004789:Enzyme Activation; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009483:Neuropsychological Tests; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D017931:DNA Primers; D006899:Mixed Function Oxygenases; C023204:tryptophan 2-monooxygenase; D014446:Tyrosine 3-Monooxygenase