title: [Effects of Shendan Jianyi Capsule on aldose reductase activity of kidney in diabetic rats].
abstract: OBJECTIVE
  To evaluate the effects of Shendan Jianyi Capsule (SDJYC) on aldose reductase (AR) activity of the kidney in diabetic rats and the significance of prevention and treatment of diabetic nephropathy with Chinese natural herbs.
  
  
  METHODS
  Diabetic Wistar rats were treated with SDJYC and sorbinil respectively, and the AR activity in kidney, urine protein and the activity of Na(+)-K(+)-ATPase were tested.
  
  
  RESULTS
  The AR activity in diabetic rats was decreased obviously after being treated with sorbinil or SDJYC. The activity of Na(+)-K(+)-ATPase in diabetic rats decreased obviously at the end of the eighth week, and increased after being treated with sorbinil and SDJYC. There was no difference between two treated groups after the treatment. It demonstrated that the inhibition of AR activity could improve the activity of Na(+)-K(+)-ATPase and SDJYC had the same effect.
  
  
  CONCLUSIONS
  SDJYC exerts effects by inhibiting the activity of AR.
authors.affiliation: Department of Metabolism and Endocrinology, First Affiliated Hospital, Anhui College of Traditional Chinese Medicine, Hefei, Anhui Province 230031, China. fangzhaohui@medmail.com.cn
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Fang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Zhang
authors.forename: Dao-Lin
authors.initials: DL
authors.lastname: Bao
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.forename: Le
authors.initials: L
authors.lastname: Luo
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000449:Aldehyde Reductase / Q000378:metabolism*; D000818:Animals; D002214:Capsules; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008516:Medicine, Chinese Traditional; D011507:Proteinuria / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013311:Streptozocin
chemical_list: D002214:Capsules; D013311:Streptozocin; D000449:Aldehyde Reductase; D000254:Sodium-Potassium-Exchanging ATPase