title: [The clinical efficacy of hemoperfusion in treatment of drug poisoning].
abstract: OBJECTIVE
  To investigate the ability of hemoperfusion to remove some drugs or toxin from the body and its clinical efficacy.
  
  
  METHODS
  Sixty-nine cases of poisoning due to tetramine or other drugs poisoning in our hospital between July 1990 and December 2003 were studied. Thirty-four patients among them received conventional treatment (including early gastric lavage, hepatoprotection, diuresis or respiratory support), and the remaining were given conventional treatment and hemoperfusion. Toxin concentration changes in blood before and after hemoperfusion, survival rate, time from come onset to regaining consciousness and convulsion termination and duration of clinical course were compared.
  
  
  RESULTS
  In the hemoperfusion group, three patients died, the survival rate was 91.4%, whereas in the non-hemoperfusion group, the survival rate was 85.3% (P > 0.05). Meanwhile the clinical course was markedly shortened in the hemoperfusion group (P < 0.05). The time from coma onset to regaining consciousness and convulsion termination in the hemoperfusion group was significantly shorter than that in the non-hemoperfusion group. The clearance rate was different for different poisons, among them the benzodiazepines had an excellent clearance.
  
  
  CONCLUSIONS
  Hemoperfusion could adsorb from blood a different amount of poisons. There is obvious efficacy in shortening clinical course and reducing complications. It could possibly raise survival rate in serious poisoning.
authors.affiliation: Affiliated Hospital, Academy of Military Medical Sciences and The Military Center of Poisoning and Treatment, Beijing 100039, China. chenj307@sina.com
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.forename: Han-bin
authors.initials: HB
authors.lastname: Wang
authors.forename: Hong-jun
authors.initials: HJ
authors.lastname: Yang
authors.forename: Ze-wu
authors.initials: ZW
authors.lastname: Qiu
authors.forename: Ri-gao
authors.initials: RG
authors.lastname: Ding
authors.forename: Shao-qing
authors.initials: SQ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000401:mortality / Q000628:therapy*; D012378:Rodenticides / Q000097:blood / Q000506:poisoning*; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D012378:Rodenticides