title: Effects of antithyroid medication on the flow-volume loop in patients with hyperthyroidism.
abstract: This prospective study was designed to evaluate the effects of hyperthyroidism on flow-volume loops in nonasthmatic 20 patients with hyperthyroidism. Thyroid related hormones (Total T3, Total T4 and TSH), thyroid gland volumes with ultrasonography, circumference of neck values and flow-volume loops were obtained at the beginning and after three months of antithyroid treatment. Propylthiouracil treatment was followed by a statistically significant decrease in thyroid gland volume and circumference of neck (p< 0.001 and p< 0.001, respectively). The most significant result was improvement of maximum midexpiratory flow rate (MMEFR) after propylthiouracil therapy for three months (p= 0.003). Increases in mean forced expiratory flow after 25% of FVC has been exhaled (FEF25), mean forced expiratory flow after 75% of FVC has been exhaled (FEF75) values were found consistent with the overall improvement in expiratory flow parameters (p= 0.044, p= 0.012 respectively). In conclusion, we speculated that improvement of expiratory flow parameters might be the earlier changes in flow volume loops of patients who were treated with propylthiouracil for hyperthyroidism.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Abant Izzet Baysal University, Düzce, Turkey. periarbak@hotmail.com
authors.forename: Peri
authors.initials: P
authors.lastname: Arbak
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Bicik
authors.forename: Alper
authors.initials: A
authors.lastname: Safak
authors.forename: Yelda
authors.initials: Y
authors.lastname: Cinar
authors.forename: Füsun
authors.initials: F
authors.lastname: Ulger
mesh_terms: D000284:Administration, Oral; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009333:Neck; D011441:Propylthiouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D012129:Respiratory Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging*; D013963:Thyroid Hormones / Q000097:blood*; D014463:Ultrasonography
chemical_list: D013956:Antithyroid Agents; D013963:Thyroid Hormones; D011441:Propylthiouracil