Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients.
BACKGROUND
Inherited predisposition has been associated with coronary artery disease (CAD) in the white population.


OBJECTIVE
The objective of this study was to investigate the association between the risk of unstable angina (UA) and genetic factors believed to be associated with an increased tendency toward thrombosis (the variable number of tandem repeats [VNTR] polymorphism of the platelet glycoprotein [GP] Ib alpha gene, Pl(A1/A2) of the platelet GP IIIa gene, 448G/A of the Bbeta fibrinogen gene and Thr312Ala of the Aalpha fibrinogen gene) in Chinese patients with UA.


METHODS
We performed a case/control study evaluating 69 Chinese patients (43 men, 26 women) with UA and 69 control subjects without CAD, individually matched for age and gender. The restriction fragment length polymorphism (RFLP) method was used to determine the genetic polymorphisms.


RESULTS
The frequencies of GP Ib alpha C/B genotype and Bbeta fibrinogen 448A allele were higher in patients with UA (46.4 vs. 30.4%, odds ratio [OR] 1.977, 95% confidence interval [CI] 0.98-3.97, p = 0.054, and 49.3 vs. 20.3%, OR 3.816, 95% CI 1.797-8.103, p = 0.000, respectively). Only four subjects (two cases, two controls) with GP IIIa Pl(A2) allele were found, and there was no association between Aalpha fibrinogen Thr312Ala polymorphism and UA.


CONCLUSIONS
Chinese patients with UA had increased frequencies of GP Ib alpha C/B genotype and Bbeta fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA.
Ni
Yongbin
Y
Department of Cardiology, Peking University People's Hospital, Beijing, People's Republic of China.
Hu
Dayi
D
Yu
Hong
H
Li
Cuilan
C
Liu
Wenling
W
Wang
Hongyu
H
Li
Lei
L
Yongbin
Ni
N
Dayi
Hu
H
Hong
Yu
Y
Cuilan
Li
L
Wenling
Liu
L
Hongyu
Wang
W
Lei
Li
L
D000328:Adult; D000368:Aged; D000483:Alleles; D000789:Angina, Unstable / Q000208:ethnology / Q000235:genetics*; D044466:Asian People; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000235:genetics*; D006801:Humans; D039661:Integrin beta3 / Q000032:analysis / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics*; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D016017:Odds Ratio; D019038:Platelet Glycoprotein GPIb-IX Complex; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
C115499:BBeta fibrinogen; D039661:Integrin beta3; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D019038:Platelet Glycoprotein GPIb-IX Complex; C094990:adhesion receptor; C464794:fibrinogen Aalpha; D005340:Fibrinogen