title: Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men.
abstract: The aim of the present study was to evaluate whether olive oils high in phenolic compounds influence the oxidative/antioxidative status in humans. Healthy men (n = 12) participated in a double-blind, randomized, crossover study in which 3 olive oils with low (LPC), moderate (MPC), and high (HPC) phenolic content were given as raw doses (25 mL/d) for 4 consecutive days preceded by 10-d washout periods. Volunteers followed a strict very low-antioxidant diet the 3 d before and during the intervention periods. Short-term consumption of olive oils decreased plasma oxidized LDL (oxLDL), 8-oxo-dG in mitochondrial DNA and urine, malondialdehyde in urine (P < 0.05 for linear trend), and increased HDL cholesterol and glutathione peroxidase activity (P < 0.05 for linear trend), in a dose-dependent manner with the phenolic content of the olive oil administered. At d 4, oxLDL after MPC and HPC, and 8-oxo-dG after HPC administration (25 mL, respectively), were reduced when the men were in the postprandial state (P < 0.05). Phenolic compounds in plasma increased dose dependently during this stage with the phenolic content of the olive oils at 1, 2, 4, and 6 h, respectively (P < 0.01). Their concentrations increased in plasma and urine samples in a dose-dependent manner after short-term consumption of the olive oils (P < 0.01). In conclusion, the olive oil phenolic content modulated the oxidative/antioxidative status of healthy men who consumed a very low-antioxidant diet.
authors.affiliation: Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d'Investigació Mèdica, Barcelona, Spain.
authors.forename: Tanja
authors.initials: T
authors.lastname: Weinbrenner
authors.forename: Montserrat
authors.initials: M
authors.lastname: Fitó
authors.forename: Rafael
authors.initials: R
authors.lastname: de la Torre
authors.forename: Guillermo T
authors.initials: GT
authors.lastname: Saez
authors.forename: Philip
authors.initials: P
authors.lastname: Rijken
authors.forename: Carmen
authors.initials: C
authors.lastname: Tormos
authors.forename: Stefan
authors.initials: S
authors.lastname: Coolen
authors.forename: Magí Farré
authors.initials: MF
authors.lastname: Albaladejo
authors.forename: Sergio
authors.initials: S
authors.lastname: Abanades
authors.forename: Helmut
authors.initials: H
authors.lastname: Schroder
authors.forename: Jaume
authors.initials: J
authors.lastname: Marrugat
authors.forename: Maria-Isabel
authors.initials: MI
authors.lastname: Covas
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism*; D008076:Cholesterol, HDL; D018592:Cross-Over Studies; D004272:DNA, Mitochondrial / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000652:urine; D000069463:Olive Oil; D010084:Oxidation-Reduction / Q000187:drug effects*; D010636:Phenols / Q000008:administration & dosage / Q000032:analysis*; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology*; D019518:Postprandial Period; D013997:Time Factors
chemical_list: D000975:Antioxidants; D008076:Cholesterol, HDL; D004272:DNA, Mitochondrial; D008077:Lipoproteins, LDL; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D005979:Glutathione Peroxidase; D003849:Deoxyguanosine