Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy.
Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm3 after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm3 and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm3. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.
Smith
Kimberly
K
Department of Infectious Diseases, Rush Medical College of Rush University, Chicago, IL 60612, USA.
Aga
Evgenia
E
Bosch
Ronald J
RJ
Valdez
Hernan
H
Connick
Elizabeth
E
Landay
Alan
A
Kuritzkes
Daniel
D
Gross
Barry H
BH
Francis
Isaac R
IR
McCune
Joseph M
JM
Kessler
Harold
H
Lederman
Michael
M
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015331:Cohort Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D011446:Prospective Studies