[Treatment of paraneoplastic pemphigus with Castleman's disease].
OBJECTIVE
To discuss the clinical findings and treatment of paraneoplastic pemphigus (PNP) with Castleman's disease.


METHODS
To investigate the clinical, histopathologic and CT findings of 8 cases paraneoplastic pemphigus with Castleman's disease.


RESULTS
All of 8 patients were diagnosed PNP first and were found Castleman's tumor incidently during routine examination. All 8 cases showed severe erosion or ulcer of the oral mucosa with various skin lesions. Histopathologically, there were intraepidermal acantholytic vesicle, basal cell liquefaction, necrotic keratinocytes in the epidermis and lymphocyte infiltration in the upper dermis. CT scan appeared solitary mass in these patients. Some of them were attacked by bronchiolitis obliterans. All 8 patients were failed by use of predisone. Obvious relief of PNP and pulmonary lesion occurred after tumor was rescted.


CONCLUSIONS
Paraneoplastic pemphigus with Castleman's disease is a rare disease. The key step is to find and resect the tumor in abdomen. CT scan should be used to detect the tumor in patients with PNP, especially, when predisone was failed in treatment.
Wu
Wen-han
WH
Department of General Surgery, First Hospital, Peking University, Beijing 100034, China.
Yang
Yin-mo
YM
Zhu
Xue-jun
XJ
Wang
Ren-gui
RG
Chen
Jun-hua
JH
Huang
Yan-ting
YT
D000293:Adolescent; D000328:Adult; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D016506:Pemphigus, Benign Familial / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D012189:Retrospective Studies