[Analysis of clinical manifestations in nasal NK/T-cell lymphomas].
OBJECTIVE
To investigate the clinical findings, histopathological features, treatment outcome as well as prognosis of nasal NK/T-cell lymphomas and to provide experiences for the diagnosis and treatment of the tumor.


METHODS
Nine cases with nasal NK/T-cell lymphomas were treated from 1990-2000. Morphological and immunohistochemical study were performed on paraffin sections. Patients underwent radiation therapy (1 case), chemotherapy (2 cases), combination of radiation and chemotherapy (6 cases), respectively.


RESULTS
Clinically, NK/T-cell lymphomas had a male predominance and most presented as ulceration of lower turbinates and nasal septum. Histopathologically, NK/T-cell lymphomas were characterized by angiocentricity, angioinvasion and necrosis. The immunophenotyes of the NK/T-cell lymphomas were CD45RO+, CD43+, CD3epsilon+, CD56+. All patients with NK/ T-cell lymphoma died, and the duration of the disease from onset to death ranged from 3-34 months.


CONCLUSIONS
Nasal NK/T-cell appear to have a male predominance, to originate more frequently in lower turbinates and nasal septum. They appears to carry a high malignancy and poor prognosis. NK/T-cell lymphomas pursue a aggressive course.
Wang
Jun
J
Department of Otorhinolaryngology-Head and Neck Surgery, First Hospital of Beijing University, Beijing, 100034, China.
Han
Dekuan
D
Yin
Hongfang
H
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000473:pathology* / Q000628:therapy; D011379:Prognosis