Catalytic enantioselective conjugate addition of trimethylsilylacetylene to 2-cyclohexen-1-one.
[reaction: see text] The first example of catalytic asymmetric conjugate addition of TMS-acetylene to a cyclic alpha,beta-enone has been accomplished using the chiral bisoxazoline-Ni complex 9 as catalyst and dimethylalumino TMS-acetylide and 2-cyclohexen-1-one as reactants.
Kwak
Young-Shin
YS
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Corey
E J
EJ