A synthetic DNA walker for molecular transport.
Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.
Shin
Jong-Shik
JS
Departments of Bioengineering and Applied & Computational Mathematics, California Institute of Technology, Pasadena, CA 91125, USA.
Pierce
Niles A
NA
D001483:Base Sequence; D040761:Biomimetic Materials / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D016547:Kinesins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
D020409:Molecular Motor Proteins; D009841:Oligonucleotides; D004247:DNA; D016547:Kinesins