[Experimental study on Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis].
OBJECTIVE
To study the effect of Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis.


METHODS
Fifty mice were randomly divided into replenishing Qi group, replenishing Yin group, replenishing Qi and Yin group, chemotherapy group and control group. Models of Lewis lung cancer and B(16) melanoma were observed in vivo. The tumor weight inhibiting rate, metastatic lung tumor, concentrations of t-PA and TXB(2) in tumor tissue and IL-2 and TNF-alpha in spleen were observed.


RESULTS
The tumor weight inhibiting rates of replenishing Qi and Yin group for Lewis lung cancer and B16 melanoma were both 42.9%. Replenishing Qi and Yin could decrease the contents of TXB(2) and 6-keto-PGF(1alpha), and increase the levels of IL-2 and TNF-alpha.


CONCLUSIONS
Replenishing Qi and Yin can promote the healthy energy to inhibiting tumor metastasis.
Li
Yong-Jian
YJ
Department of Oncology, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu Province 215003, China.
D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D007376:Interleukin-2 / Q000032:analysis; D008297:Male; D008516:Medicine, Chinese Traditional; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D010959:Tissue Plasminogen Activator / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D010959:Tissue Plasminogen Activator