title: [Clinical study on treatment of patients with upper digestive tract malignant tumors of middle and late stage with Ginkgo biloba exocarp polysaccharides capsule preparation].
abstract: OBJECTIVE
  To observe the clinical efficacy of Ginkgo biloba exocarp polysaccharides (GBEP) capsule preparation in treating upper digestive tract malignant tumors of middle and late stage.
  
  
  METHODS
  Eighty-six patients of the upper digestive tract malignant tumors were treated with GBEP capsule preparation taken orally. The clinical symptoms and the qualities of life of the patients with single GBEP and combined with operation, radiotherapy or intervention chemotherapy were observed. The tumor size was measured by electronic gastroscope before and after treatment with single GBEP. Objective response rate (RR) of the tumor was calculated. The survival period of patient was observed. The changes of blood routine examination in the patients treated with radiotherapy were observed.
  
  
  RESULTS
  GBEP preparation could markedly improve the patients'clinical symptoms. Karnofsky scoring of the patients markedly increased after treatment. There were 2 CR (complete response, 6.3%), 22 PR (partial response, 68.8%)and 5 SD (stable disease, 15.6%) of 32 cases with single GBEP preparation. The survival periods of the 32 cases were markedly prolonged. The preparation could relieve the inhibited hematopietic function and the weight loss due to radiotherapy.
  
  
  CONCLUSIONS
  GBEP capsule preparation has some definite therapeutic effects on upper digestive tract malignant tumors of middle and late stage.
authors.affiliation: Department of Prescription and Chinese Drugs, Medical College of Yangzhou University, Yangzhou, Jiangsu Province 225001, China. yzchs@elong.com
authors.forename: Hua-Sheng
authors.initials: HS
authors.lastname: Chen
authors.forename: Fan
authors.initials: F
authors.lastname: Zhai
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Chu
authors.forename: Fang
authors.initials: F
authors.lastname: Xu
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Xu
authors.forename: Lin-Chang
authors.initials: LC
authors.lastname: Jia
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002214:Capsules; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D005260:Female; D020441:Ginkgo biloba; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage / Q000627:therapeutic use*; D011134:Polysaccharides / Q000008:administration & dosage / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D015996:Survival Rate; D016896:Treatment Outcome; D041742:Upper Gastrointestinal Tract / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects
chemical_list: D002214:Capsules; D028321:Plant Preparations; D011134:Polysaccharides