title: [GERD and tight junction proteins of the esophageal mucosa].
abstract: Recent advancement in the research of GERD has revealed that endoscopy negative GERD may not be a milder form of erosive GERD and may have different pathogenesis. We have previously proven that hypersensitivity to the acid of the esophageal mucosa plays an important role in its pathogenesis. Regarding the mechanisms for the esophageal hypersensitivity, we hypothesized that the tight junction proteins of the esophageal mucosa are fully or partially impaired in GERD patients. Accordingly, we immunohistologically studied the expression of various tight junction proteins using the rat reflux esophagitis model. The results demonstrated that the several kinds of tight junction proteins are expressed differently in the various parts of esophagus and their expression altered according to the development of reflux esophagitis.
authors.affiliation: Department of Gastroenterology, Juntendo University, School of Medicine.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Miwa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Asaoka
authors.forename: Mariko
authors.initials: M
authors.lastname: Hojo
authors.forename: Katsuyori
authors.initials: K
authors.lastname: Iijima
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sato
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004945:Esophagoscopy; D004947:Esophagus / Q000166:cytology / Q000378:metabolism / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D009092:Mucous Membrane / Q000166:cytology / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D019108:Tight Junctions / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins