title: Volume flow rate evaluation in patients with obstructive arteriosclerotic disease.
abstract: This study was performed to quantify the volumetric impact of extracranial arteriosclerotic lesions. We investigated patients with different degrees of carotid stenosis as defined by conventional velocity-based duplex criteria and different patterns of collateralization. We studied the volume flow rate (color duplex M-mode device) in 37 patients with symmetrical internal carotid artery (ICA) plaques (<50% stenosis) and compared these data to 43 patients with a unilateral 50-74% stenosis, 75-99% stenosis (n = 73) and occlusion of the ICA (n = 37). A 75-99% stenosis caused an ipsilateral flow reduction of 36% with a wide interindividual variability, and an occlusion of 51%. Collateralization via the ophthalmic artery only caused a nonsignificant ipsilateral volume flow increase, whereas the contralateral volume flow was significantly higher in patients with a patent anterior communicating artery. The increase was more pronounced in patients with an occluded vessel. Our data demonstrate a wide diversity of the hemodynamic impact of carotid stenosis as defined by 'classical' Doppler criteria. Collateral flow reflects a dynamic quantitative process.
authors.affiliation: Department of Clinical Neurophysiology, Georg-August University Göttingen, Göttingen, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Doberenz
authors.forename: Walter
authors.initials: W
authors.lastname: Paulus
authors.forename: Carl D
authors.initials: CD
authors.lastname: Reimers
authors.forename: B Martin
authors.initials: BM
authors.lastname: Eicke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020771:Anterior Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003097:Collateral Circulation / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology; D012720:Severity of Illness Index; D018615:Ultrasonography, Doppler, Color