title: Accumulation and tissue distribution of selected polychlorinated biphenyl congeners in chickens.
abstract: During one to three consecutive periods of 2 weeks, broiler chickens (n = 108) received test dies to which different amount of PCBs (7 congeners) were added. The relationship between exposure time and accumulation of individual congeners in different chicken tissues, such as breast, thigh and abdominal fat tissue, was observed. In all tissues, the vast majority of the PCB accumulation occurred during the first 2 weeks of exposures. After that, PCB concentrations only increased in the abdominal fat tissue of the animals. The individual PCBs were distributed differently in the various tissues. While CBs 28, 118, 138, 153 and 180 accumulated in the chickens, CBs 52 and 101 were metabolized, but no methyl sulphone metabolites of these congeners could be detected. Our results provide information on the absorption, tissue distribution and biotransformation of the individual PCB congeners and confirm the structure-activity relationships for metabolism of PCBs in birds, which are different from those in fish or mammalian species.
authors.affiliation: Toxicological Center, University of Antwerp, B-2610 Wilrijk, Belgium. johan.maervoet@ua.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Maervoet
authors.forename: S G
authors.initials: SG
authors.lastname: Chu
authors.forename: S
authors.initials: S
authors.lastname: De Vos
authors.forename: A
authors.initials: A
authors.lastname: Covaci
authors.forename: S
authors.initials: S
authors.lastname: Voorspoels
authors.forename: R
authors.initials: R
authors.lastname: De Schrijver
authors.forename: P
authors.initials: P
authors.lastname: Schepens
mesh_terms: D000042:Absorption; D000704:Analysis of Variance; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001711:Biotransformation / Q000502:physiology; D002645:Chickens / Q000378:metabolism*; D002849:Chromatography, Gas; D005506:Food Contamination / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000378:metabolism / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D011078:Polychlorinated Biphenyls