The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot study.
Pharmacologic doses of growth hormone (GH) reduce HIV-associated fat accumulation but may worsen glucose metabolism. We investigated the effects of a low dose of GH (1 mg per day) in HIV-infected men with fat accumulation and found that such treatment reduced total fat and increased lean body mass without significant changes in glucose tolerance or insulin sensitivity. Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline.
Lo
Joan C
JC
Div. of Endocrinology, General Clinical Research Center at San Francisco General Hospital, San Francisco, California 94110, USA. jlo@itsa.ucsf.edu
Mulligan
Kathleen
K
Noor
Mustafa A
MA
Lee
Grace A
GA
Schwarz
Jean-Marc
JM
Grunfeld
Carl
C
Schambelan
Morris
M
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001823:Body Composition; D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D004334:Drug Administration Schedule; D013006:Growth Hormone / Q000008:administration & dosage* / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
D013006:Growth Hormone