title: Adult-onset idiopathic hypogonadotropic hypogonadism due to isolated pituitary gonadotropin deficiency.
abstract: A 25-year-old Japanese man with adult-onset idiopathic hypogonadotropic hypogonadism is reported. He had been delivered normally, had normal puberty, and experienced erectile dysfunction at age 24 years. Brain MRI revealed no abnormal findings and endocrinological data supported the diagnosis of isolated gonadotropin deficiency. Although most patients with idiopathic hypogonadotropic hypogonadism have a hypothalamic dysfunction, the lesion in this case may be considered to be in the pituitary since repetitive GnRH loading failed to increase serum LH and FSH.
authors.affiliation: Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo.
authors.forename: Fumika
authors.initials: F
authors.lastname: Suzuki
authors.forename: Chikara
authors.initials: C
authors.lastname: Shimizu
authors.forename: Masaaki
authors.initials: M
authors.lastname: Umetsu
authors.forename: So
authors.initials: S
authors.lastname: Nagai
authors.forename: Jun
authors.initials: J
authors.lastname: Takeuchi
authors.forename: Mikiko
authors.initials: M
authors.lastname: Endo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Narihito
authors.initials: N
authors.lastname: Yoshioka
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Kubo
authors.forename: Takao
authors.initials: T
authors.lastname: Koike
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000209:etiology; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis* / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000503:physiopathology*; D018570:Risk Assessment
chemical_list: D006063:Chorionic Gonadotropin; D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone