Resistin/ADSF/FIZZ3 in obesity and diabetes.
The role of adipocyte-secreted resistin/adipocyte-specific secretory factor (ADSF)/FIZZ3 in obesity and diabetes has been controversial at best. Recently generated resn knockout mice showed normal glucose and insulin sensitivity with lower fasting glucose levels. Upon feeding with a high-fat diet, the knockout mice exhibited increased glucose tolerance with decreased hepatic glucose output, possibly due to phosphorylation and activation of AMP-activated protein kinase and suppression of gluconeogenic genes. In comparison, transgenic mice overexpressing a dominant negative form of resistin/ADSF/FIZZ3 showed increased adiposity with elevated leptin and adiponectin levels, accompanying enhanced glucose tolerance and insulin sensitivity both on chow and high-fat diets. Although its underlying mechanisms need further elucidation, the in vivo studies demonstrate a role of resistin/ADSF/FIZZ3 in obesity and insulin resistance.
Sul
Hei Sook
HS
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA. hsul@nature.berkeley.edu
D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D006729:Hormones, Ectopic / Q000235:genetics / Q000502:physiology*; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D052243:Resistin
D006729:Hormones, Ectopic; D011506:Proteins; D052243:Resistin; C499623:Retn protein, mouse; D000450:Aldosterone