Ectopic growth hormone-releasing adenoma in the cavernous sinus--case report.
A 55-year-old woman presented a rare ectopic pituitary adenoma in the right cavernous sinus manifesting as acromegaly. The tumor was removed via transsphenoidal approach. Intraoperative observation showed the adenoma was located entirely within the right cavernous sinus, and separated from the normal pituitary gland by the medial wall of the cavernous sinus. There was no communication between the tumor and the pituitary. Histological examination showed a growth hormone-releasing adenoma. Including our case, only eight of 86 reported ectopic adenomas have occurred in the cavernous sinus. Such ectopic presentation may be responsible for failed transsphenoidal surgery for endocrinologically active tumors.
Mitsuya
Koichi
K
Division of Neurosurgery, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan. k.mitsuya@scchr.jp
Nakasu
Yoko
Y
Nioka
Hirofumi
H
Nakasu
Satoshi
S
D000172:Acromegaly / Q000209:etiology*; D000239:Adenoma, Acidophil / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D002426:Cavernous Sinus / Q000473:pathology / Q000601:surgery*; D002828:Choristoma / Q000175:diagnosis / Q000601:surgery*; D003937:Diagnosis, Differential; D004724:Endoscopy; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010902:Pituitary Gland; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D011388:Prolactin / Q000378:metabolism; D019043:Vascular Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D011388:Prolactin