YidC family members are involved in the membrane insertion, lateral integration, folding, and assembly of membrane proteins.
Members of the YidC family exist in all three domains of life, where they control the assembly of a large variety of membrane protein complexes that function as transporters, energy devices, or sensor proteins. Recent studies in bacteria have shown that YidC functions on its own as a membrane protein insertase independent of the Sec protein-conducting channel. YidC can also assist in the lateral integration and folding of membrane proteins that insert into the membrane via the Sec pathway.
Dalbey
Ross E
RE
Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA. dalbey@chemistry.ohio-state.edu
Kuhn
Andreas
A
D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D017510:Protein Folding; D011498:Protein Precursors / Q000378:metabolism*; D013379:Substrate Specificity
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D011498:Protein Precursors