title: Comparison of wavefront aberration changes in the anterior corneal surface after laser-assisted subepithelial keratectomy and laser in situ keratomileusis: preliminary study.
abstract: OBJECTIVE
  To compare changes in anterior corneal wavefront aberrations after myopic laser-assisted subepithelial keratectomy (LASEK) and laser in situ keratomileusis (LASIK).
  
  
  METHODS
  Institute of Ophthalmology, Catholic University, Rome, Italy.
  
  
  METHODS
  This prospective study included 36 eyes of 25 myopic patients: 18 eyes of 12 patients had LASEK and 18 eyes of 13 patients, LASIK. The topography data (CSO EyeMap, version 6.2) were used to calculate corneal aberrations with 3.0 mm and 7.0 mm pupils before and 3 months after surgery.
  
  
  RESULTS
  Total corneal aberrations increased similarly after LASEK and LASIK with the 7.0 mm pupil but did not change with the 3.0 mm pupil. Coma-like and spherical-like aberrations changed similarly after both procedures, but spherical-like aberrations increased after LASEK with the 3.0 mm pupil (P<.05, independent t test). With the 7.0 mm pupil, the amount of achieved correction was positively correlated with changes in total corneal aberrations after LASIK (P =.007) and with spherical-like aberrations after LASEK (P =.03) and LASIK (P<.003). Although there was no significant difference between LASEK and LASIK (P>.05, independent t test), in individual eyes with an achieved correction less than 7.50 diopters (D), spherical-like aberrations increased more after LASEK than after LASIK.
  
  
  CONCLUSIONS
  In this preliminary study, myopic LASEK and LASIK changed total and higher-order corneal aberrations. In both procedures, changes in spherical-like aberrations were dependent on the achieved correction. However, in individual eyes, spherical-like aberrations increased more after LASEK than after LASIK for low-moderate achieved correction, suggesting that these procedures may induce the same optical changes in the anterior corneal surface in different ways.
authors.affiliation: Institute of Ophthalmology, Catholic University, Gemelli 8-00168 Rome, Italy. lbuzzonetti@tibernet.it
authors.forename: Luca
authors.initials: L
authors.lastname: Buzzonetti
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Iarossi
authors.forename: Paola
authors.initials: P
authors.lastname: Valente
authors.forename: Marzia
authors.initials: M
authors.lastname: Volpi
authors.forename: Gianni
authors.initials: G
authors.lastname: Petrocelli
authors.forename: Luigi
authors.initials: L
authors.lastname: Scullica
mesh_terms: D000328:Adult; D000465:Algorithms; D003319:Corneal Stroma / Q000503:physiopathology*; D019781:Corneal Topography; D019573:Epithelium, Corneal / Q000503:physiopathology*; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D009216:Myopia / Q000503:physiopathology* / Q000601:surgery*; D011446:Prospective Studies; D012029:Refraction, Ocular; D013524:Surgical Flaps; D014945:Wound Healing