Differential gene expression after implantation of biomaterials into rat gastrointestine.
Two biodegradable materials, polyglycolide-copoly(L)-lactide/poly-dioxanone composite and poly(3-hydroxybutyrate), have been employed for surgery in the gastrointestine of laboratory rats. The tissue response was analyzed at distinct time intervals up to 2 months by differential mRNA display. Two specific PCR fragments were transiently present 7 and 14 days after contact with poly(3-hydroxybutyrate). Both fragments represent distinct rat lipases which might play a role in poly(3-hydroxybutyrate) degradation.
Löbler
M
M
Chirurgische Universitätsklinik, Universität Rostock, Schillingallee 35, D-18057 Rostock, Germany. marian.loebler@medizin.uni-rostock.de
Sass
M
M
Michel
P
P
Hopt
U T
UT
Kunze
C
C
Schmitz
K P
KP