Ehlers-Danlos Syndrome (EDS) focusing on oral symptoms: a questionnaire study.
OBJECTIVE
To study the prevalence of oral problems reported among a large group of adults with Ehlers-Danlos Syndrome (EDS). Furthermore, to compare proportions of disorders and general psychological well-being with those in a cohort of randomized population-based controls.


METHODS
A questionnaire study.


METHODS
A total of 265 persons with EDS (response rate 77%) and 750 controls (response rate 63%) in a population-based cohort. Sixty persons were excluded from the EDS group (support members, children, undiagnosed EDS) leaving a final study group of 144 adults. The final control group consisted of 331 persons since many had sent back unanswered questionnaires.


METHODS
Questions concerning general and oral symptoms, VAS scales for masticatory muscle pain ratings and General Health Questionnaire (GHQ12) questions were included.


METHODS
Proportions of affirmative answers in EDS group and controls were compared. Mean values for ratings on VAS scales. Proportions of GHQ12 scores with a threshold score of four or more.


RESULTS
The proportions of affirmative answers for persons with EDS concerning general health problems, oral problems and masticatory muscle symptoms were significantly higher compared with controls. In the EDS group those who had daily pain in the masticatory muscles had significantly higher mean values on the VAS scales compared with those who had pain a few days per month. A GHQ12 score of four or more was significantly more common in the EDS group than in the controls, suggesting that a decline in psychological well-being was also more common in this group.


CONCLUSIONS
It is important that dental practitioners should be aware of the oral problems associated with EDS and the impact the disease has on quality of life.
Hagberg
Catharine
C
Mun-H-Center, Swedish National Orofacial Center for Rare Disorders, Göteborg, Sweden. catharina.hagberg@vgregion.se
Berglund
Britta
B
Korpe
Lena
L
Andersson-Norinder
Jan
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001294:Attitude to Health; D015331:Cohort Studies; D004535:Ehlers-Danlos Syndrome / Q000150:complications* / Q000523:psychology; D005157:Facial Pain / Q000209:etiology; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008410:Masticatory Muscles / Q000473:pathology; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology* / Q000523:psychology; D010147:Pain Measurement; D011159:Population Surveillance; D011788:Quality of Life