[Rectal stromal tumors: a clinicopathological study of 16 cases].
OBJECTIVE
To investigate the clinical diagnosis, treatment and immunohistochemical characteristics of rectal stromal tumors.


METHODS
Immunohistochemical expression of CD117 was retrieved in 20 cases of mesenchymal tumors of the rectum. And we analyzed the immunohistochemical characteristics, clinical data of rectal stromal tumors, and the results retrospectively.


RESULTS
Sixteen cases of rectal stromal tumors, 3 cases of leiomyosarcomas and 1 case of schwannoma were diagnosed. Histologically, 2 cases of GISTs were classified as benign, 1 as borderline and 13 as malignant. All of rectal stromal tumors (100%) were strongly positive for CD117, and 14 cases (88%) positive for CD34. The demographic profile of rectal stromal tumors showed a male predominance with average age of 60 years old. The main symptoms were urinary retention, constipation and abdominal pain. 14 cases were positive in digital rectal examination. The recurrence rate of local and radical resection in malignant stromal tumors was 4/4 and 3/6. 1, 3, 5-year survival rates were 89%, 64%, 48%, respectively. After operation mean survival time of was 47 months.


CONCLUSIONS
The specific GIST constituted the majority of mesenchymal tumors in rectum. It usually showed malignant biological behavior. Invasion and recurrence were common. Earlier diagnosis and radical resection had better prognosis. Periodically following up can help to detect the recurrence timely.
Wan
Yuan-Lian
YL
Department of General Surgery, First Hospital, Peking University, Beijing 100034, China.
Tang
Jian-Qiang
JQ
Liu
Ping
P
Liu
Yu-Cun
YC
Wang
Xin
X
Wu
Tao
T
Pan
Yi-Sheng
YS
Huang
Yan-Ting
YT
D000328:Adult; D000368:Aged; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies