title: [The gene expression of Th1/Th2 cytokines and its role in hypopharyngeal carcinoma].
abstract: OBJECTIVE
  To observe the mRNA expression of Th1/Th2 cytokines in hypopharyngeal neoplasms and to explore the pathogenesis of it.
  
  
  METHODS
  The gene expression of Th1/Th2 cytokines in patients with hypopharyngeal neoplasms was detected by RT-PCR.
  
  
  RESULTS
  The cytokines expression of Th2 was significantly stronger than Th1 in tissue of hypopharyngeal carcinoma.
  
  
  CONCLUSIONS
  The dominant expression of Th2 cytokines in hypopharyngeal neoplasms may inhibit the human immunity and enhance the growth and metastasis of hypopharyngeal carcinoma.
authors.affiliation: Department of Otolaryngology, the Second Affiliated Hospital of Shandong University, Jinan, 250033, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Chen
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Xu
authors.forename: Jiandong
authors.initials: J
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Aiying
authors.initials: A
authors.lastname: Xue
authors.forename: Daliang
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000368:Aged; D005260:Female; D015870:Gene Expression; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology*; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D015847:Interleukin-4 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D016753:Interleukin-10; D015847:Interleukin-4