Efficiency of antidepressant drugs as monoamine reuptake inhibitors: analysis of the hydrophobicity influence using biopartitioning micellar chromatographic data.
The reuptake blockade of biogenic amines by antidepressants is related not only to their therapeutics effects, but also to their side effects and potential drug-drug interactions. As an alternative to classical quantitative structure-activity relationships studies, in this work we propose different quantitative retention-activity relationships (QRAR) models that are able to describe the monoamine reuptake inhibition by antidepressants. The retention of compounds is measured using a biopartitioning micellar chromatography (BMC) system that can simulate the same hydrophobic, electronic and steric molecular interactions as those that condition drug activity. Since all the compounds considered in this work are structurally related because all of them share the same molecular features as the corresponding basic pharmacophore, the results obtained show that there is a retention range in which antidepressants present the highest monoamine reuptake inhibitor potency.
Quiñones-Torrelo
C
C
Departamento de Química Analítica, Facultad de Farmacia, Universidad de Valencia, C/Vicente Andrés Estellés, s/n. 46100 Burjassot, Valencia, Spain.
Sagrado
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S
Villanueva-Camañas
R M
RM
Medina-Hernández
M J
MJ
D000928:Antidepressive Agents / Q000032:analysis / Q000627:therapeutic use*; D015306:Biogenic Monoamines / Q000378:metabolism*; D002853:Chromatography, Liquid / Q000379:methods*; D008823:Micelles; D014179:Neurotransmitter Uptake Inhibitors / Q000032:analysis / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D008823:Micelles; D014179:Neurotransmitter Uptake Inhibitors