[Successful treatment of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b meningitis with high-dose ceftriaxone administration].
Haemophilus influenzae type b (Hib) is the most frequent pathogen of bacterial meningitis in Japanese children. The prevalence of beta-lactamase-negative ampicillin-resistant (BLNAR) Hib strain has been increasing in recent years. Furthermore, antibiotic activities of cefotaxime (CTX) and ceftriaxone (CTRX) have decreased against some of those BLNAR strains. We report a case of one-year-old boy who suffered from meningitis caused by BLNAR Hib. The MICs of CTX and CTRX for the strain isolated from cerebrospinal fluid was 1.0 and 0.5 microg/ml, respectively. The patient was administered high-dose CTRX (150 mg/kg/day) and recovered completely without any sequela. The high-dose CTRX administration may be a considerable choice of the treatment of BLNAR meningitis.
Sudo
Fusayo
F
Division of Infectious Diseases, Chiba Children's Hospital.
Nakamura
Akira
A
Hoshino
Tadashi
T
Ishiwada
Naruhiko
N
Kohno
Yoichi
Y
D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002443:Ceftriaxone / Q000008:administration & dosage*; D019741:Haemophilus influenzae type b / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D007223:Infant; D008297:Male; D008583:Meningitis, Haemophilus / Q000188:drug therapy*; D001618:beta-Lactamases
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D001618:beta-Lactamases