Identification of new HLA-C alleles by polymerase chain reaction-sequence specific oligonucleotide typing: Cw*0314 and Cw*1511*.
In this article, we report two new human leukocyte antigen-C (HLA-C) alleles, HLA-Cw*0314 and Cw*1511, which were identified during routine tissue typing of donors for the Australian Bone Marrow Donor Registry and Australian Cord Blood Bank. HLA-Cw*0314 shows six codon changes in exon 3 compared to Cw*030401 and shares some sequence homology with Cw*07 alleles. Cw*1511 has two nucleotide changes compared with Cw*150201 in exon 2, both resulting in amino acid changes in the protein sequence.
Chapman
G
G
Molecular Genetics, Tissue Typing, Australian Red Cross Blood Service, Sydney, NSW, Australia.
Kennedy
C
C
Greville
W D
WD
Dodd
R
R
Hersee
J
J
Taverniti
A
A
Le
T
T
Wallace
R
R
Kennedy
A
A
Dunckley
H
H
D000483:Alleles; D001315:Australia; D001483:Base Sequence; D018070:Biological Specimen Banks; D001853:Bone Marrow / Q000378:metabolism; D015343:DNA Probes, HLA / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005312:Fetal Blood / Q000378:metabolism; D014644:Genetic Variation; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D015343:DNA Probes, HLA; D015236:HLA-C Antigens