Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity.
Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.
Shin
Dong-Yun
DY
College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, 151-742, South Korea.
Kim
Sun Nam
SN
Chae
Jung-Hyun
JH
Hyun
Soon-Sil
SS
Seo
Seung-Yong
SY
Lee
Yong-Sil
YS
Lee
Kwang-Ok
KO
Kim
Seok-Ho
SH
Lee
Yun-Sang
YS
Jeong
Jae Min
JM
Choi
Nam-Song
NS
Suh
Young-Ger
YG
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D016106:Methicillin Resistance / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; D012717:Sesquiterpenes; C496018:mansonone F