Neuropeptide Y and epilepsy: recent progress, prospects and controversies.
Neuropeptide Y (NPY), a 36 amino-acid member of the pancreatic polypeptide family, has received considerable attention in recent years as an endogenous modulator of epileptic activity. Prominently expressed in brain regions involved in seizure generation and propagation, NPY can exert powerful effects on synaptic transmission. Here, we discuss the anti-epileptic actions of NPY and receptor subtypes responsible.
Baraban
S C
SC
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA. baraban@itsa.ucsf.edu
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D004827:Epilepsy / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism*; D017476:Receptors, Neuropeptide Y / Q000378:metabolism
D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; C095889:neuropeptide Y2 receptor; C100568:neuropeptide Y5 receptor