Sesquiterpene esters from the fruits of Celastrus orbiculatus.
Three new beta-dihydroagarofuran sesquiterpene esters, 6 alpha-acetoxy-9 beta-benzoyloxy-1 beta-cinnamoyloxy-8 beta-butanoyloxy-beta-dihydroagarofuran (1), 6 alpha-acetoxy-9 beta-benzoyloxy-1 beta-cinnamoyloxy-8 beta-(2-methylbutanoyloxy)-beta-dihydroagarofuran (2), and 6 alpha-acetoxy-1 beta,8 beta-dibenzoyloxy-9 beta-hydroxy-beta-dihydroagarofuran (6), together with three known compounds (3-5) were isolated from the fruits of Celastrus orbiculatus THUNB. Their structures were elucidated on the basis of spectroscopic methods. Compound 4 showed moderate activity in inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells with an IC(50) value of 43.7 microM.
Guo
Yuan Qiang
YQ
Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China.
Li
Xian
X
Xu
Jing
J
Li
Ning
N
Meng
Da Li
DL
Wang
Jin Hui
JH
D000818:Animals; D031247:Celastrus / Q000737:chemistry*; D002460:Cell Line; D005638:Fruit / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide