title: 1800 MHz radiofrequency (mobile phones, different Global System for Mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors.
abstract: OBJECTIVE
  To study if prolonged in vitro exposure to 1800MHz radiofrequency (RF) could exert an effect on human peripheral blood mononuclear cells (PBMC) from young and elderly donors by affecting apoptosis, mitochondrial membrane potential and heat shock protein (HSP) 70 levels.
  
  
  METHODS
  Endpoints were analysed in the presence or absence of the apoptosis-inducing agent 2-deoxy-D-ribose. Three different signal modulations typical of the Global System for Mobile communication (GSM) system were applied. The modulations are widely used in mobile telephony (GSM Basic, discontinuous transmission [DTX] and Talk) at specific absorption rates of 1.4 and 2.0 W kg(-1).
  
  
  RESULTS
  In all conditions and for all endpoints tested, there was no significant difference between RF- and sham-exposed cells.
  
  
  CONCLUSIONS
  1800MHz RF could not induce apoptosis by itself or affect the apoptotic phenomenon when induced by an apoptotic agent. Moreover, RF did not modify the mitochondrial functionality and the expression of HSP 70.
authors.affiliation: Department of Experimental Pathology, Section of Immunology, CIG-Centro Interdipartimentale L. Galvani, Via S. Giacomo 12, University of Bologna, Italy. miriam@alma.unibo.it
authors.forename: M
authors.initials: M
authors.lastname: Capri
authors.forename: E
authors.initials: E
authors.lastname: Scarcella
authors.forename: E
authors.initials: E
authors.lastname: Bianchi
authors.forename: C
authors.initials: C
authors.lastname: Fumelli
authors.forename: P
authors.initials: P
authors.lastname: Mesirca
authors.forename: C
authors.initials: C
authors.lastname: Agostini
authors.forename: D
authors.initials: D
authors.lastname: Remondini
authors.forename: J
authors.initials: J
authors.lastname: Schuderer
authors.forename: N
authors.initials: N
authors.lastname: Kuster
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
authors.forename: F
authors.initials: F
authors.lastname: Bersani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects*; D040421:Cell Phone; D003855:Deoxyribose / Q000494:pharmacology; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D011846:Radio Waves / Q000009:adverse effects*
chemical_list: D018840:HSP70 Heat-Shock Proteins; D003855:Deoxyribose