title: Incidence and disease-free survival after surgical therapy of central giant cell granulomas of the jaw in The Netherlands: 1990-1995.
abstract: BACKGROUND
  The central giant cell granuloma (CGCG) of the jaw is a rare benign tumor with an unknown etiology. Epidemiologic data on CGCGs in a general population are not available, nor are data on the overall outcome of surgical therapy. In this article, an overview of these aspects in the Dutch population from January 1, 1990, until January 1, 1995, is presented.
  
  
  METHODS
  All CGCGs that were diagnosed and surgically treated in The Netherlands from 1990 until 1995 were evaluated.
  
  
  RESULTS
  The incidence is 0.00011%, and the disease-free survival after surgical therapy after 5 years is 76.1%. There is a significantly higher recurrence rate in young males, which cannot be explained by clinical signs and symptoms of the lesion.
  
  
  CONCLUSIONS
  The CGCG is a rare affliction with a high recurrence rate after surgical therapy, especially in young males.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Academic Medical Center/Academic Center for Dentistry (ACTA), University of Amsterdam, The Netherlands. kaakchirurgie@isala.nl
authors.forename: Jan
authors.initials: J
authors.lastname: de Lange
authors.forename: Hans P
authors.initials: HP
authors.lastname: van den Akker
authors.forename: Helen
authors.initials: H
authors.lastname: Klip
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006101:Granuloma, Giant Cell / Q000453:epidemiology* / Q000601:surgery*; D006801:Humans; D015994:Incidence; D007223:Infant; D007571:Jaw Diseases / Q000453:epidemiology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012008:Recurrence; D017678:Sex Distribution