title: Medallion-like dermal dendrocyte hamartoma: a new clinically and histopathologically distinct lesion.
abstract: Dermal dendrocyte hamartomas are extremely rare; only two examples have been described with clinical features different from our cases and with incomplete immunohistochemical characterization. We report three female patients presenting a medallion-shaped, well-defined, slightly atrophic and asymptomatic congenital lesion. All 3 patients showed a fusiform-cell proliferation. Immunohistochemistry was positive for CD34, factor XIIIa, and fascin. Electron microscopy showed typical features of dermal dendrocytes. We believe that the lesions described represent a new, clinically and histopathologically distinct lesion originating in dermal dendrocytes. We propose to name it medallion-like dermal dendrocyte hamartoma.
authors.affiliation: Department of Pathology, National Institute of Pediatrics, Mexico.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Rodríguez-Jurado
authors.forename: Carolina
authors.initials: C
authors.lastname: Palacios
authors.forename: Carola
authors.initials: C
authors.lastname: Durán-McKinster
authors.forename: Patricia
authors.initials: P
authors.lastname: Mercadillo
authors.forename: Luz
authors.initials: L
authors.lastname: Orozco-Covarrubias
authors.forename: Maria del Mar
authors.initials: Mdel M
authors.lastname: Saez-de-Ocariz
authors.forename: Ramón
authors.initials: R
authors.lastname: Ruiz-Maldonado
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D026122:Factor XIIIa / Q000032:analysis; D005260:Female; D006222:Hamartoma / Q000145:classification / Q000151:congenital / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008840:Microfilament Proteins / Q000032:analysis; D008854:Microscopy, Electron; D009455:Neurofibroma / Q000175:diagnosis; D012871:Skin Diseases / Q000145:classification / Q000151:congenital / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D002352:Carrier Proteins; D008840:Microfilament Proteins; D014746:Vimentin; C020324:fascin; D026122:Factor XIIIa