title: [Antiulcer activity of furoxanopyrimidine derivatives].
abstract: A series of four new furoxanopyrimidine derivatives was synthesized and studied with respect to antiulcerous, antisecretory, and antibacterial activity. Two compounds exhibit antiulcerous effect not accompanied (in contrast to the well-known H2 receptor blockers, quiditene, and other antiulcerous drugs) by inhibition of gastric acid secretion. No one of the studied compounds exhibited antibacterial activity in the tests with Helicobacter pylori.
authors.forename: M E
authors.initials: ME
authors.lastname: Kaminka
authors.forename: M A
authors.initials: MA
authors.lastname: Kalinkina
authors.forename: T V
authors.initials: TV
authors.lastname: Pushkina
authors.forename: S M
authors.initials: SM
authors.lastname: Tupikina
authors.forename: O B
authors.initials: OB
authors.lastname: Riabova
authors.forename: V A
authors.initials: VA
authors.lastname: Makarov
authors.forename: V G
authors.initials: VG
authors.lastname: Granik
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D016480:Helicobacter pylori / Q000187:drug effects; D008297:Male; D020030:Nitric Oxide Donors / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000897:Anti-Ulcer Agents; D020030:Nitric Oxide Donors; D010069:Oxadiazoles; D011743:Pyrimidines; C010166:furoxans