title: Medicine. Targeting apoptotic pathways in cancer cells.
authors.affiliation: Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0686, USA. sdowdy@ucsd.edu
authors.forename: Catherine
authors.initials: C
authors.lastname: Denicourt
authors.forename: Steven F
authors.initials: SF
authors.lastname: Dowdy
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D019943:Amino Acid Substitution; D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D053280:Diynes; D004705:Endocytosis; D005909:Glioblastoma / Q000188:drug therapy; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins; D007942:Leukemia, Experimental / Q000188:drug therapy; D017254:Leukemic Infiltration / Q000188:drug therapy; D008024:Ligands; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D018716:Molecular Mimicry; D010446:Peptide Fragments / Q000737:chemistry; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D015202:Protein Engineering; D025941:Protein Interaction Mapping; D017433:Protein Structure, Secondary; D011506:Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: C491032:1,6-bis(4,7-diaza-6-methyl-5-oxo-3-((2-((5-(phenylthio)tetrazol-1-yl)methyl)pyrrolidin-1-yl)carbonyl)octyloxy)-2,4-hexadiyne; D000480:Alkynes; D051017:Apoptosis Regulatory Proteins; C474007:Bax protein (53-86); D001952:Bridged-Ring Compounds; D002352:Carrier Proteins; C412403:DIABLO protein, human; C499605:Diablo protein, mouse; D053280:Diynes; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D024101:Mitochondrial Proteins; D010446:Peptide Fragments; D019151:Peptide Library; D010455:Peptides; D011506:Proteins; D011518:Proto-Oncogene Proteins; D013777:Tetrazoles; D014409:Tumor Necrosis Factor-alpha