Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease.
The transport of amyloid precursor protein is mediated through its interaction with kinesin light-chain 1 (KNS2). We hypothesized that kinesin light-chain dysfunction might be involved in the pathogenesis of Alzheimer's disease (AD). To assess the physiological relevance of an allelic variation in the KNS2 gene, the association analysis of three single nucleotide polymorphisms (SNPs) in the 5'UTR or in intronic sequences of KNS2 gene were performed in 100 AD brain patients and in 103 controls. For one of these polymorphisms (G58836C in intron 13), the association between AD and the C allele was found to be significant (odds ratio = 1.73, 95% CI: 1.12-2.67, P = 0.012). No synergistic effects were found between the APOE epsilon 4 allele and KNS2 gene polymorphisms.
Dhaenens
Claire-Marie
CM
Groupe Vieillissement Cérébral et Maladies Neurodégénératives, INSERM U422, Laboratoire G. Biserte et Faculté de Médecine, Université de Lille 2, Place de Verdun 59045, Lille Cedex, France.
Van Brussel
Edwige
E
Schraen-Maschke
Susanna
S
Pasquier
Florence
F
Delacourte
André
A
Sablonnière
Bernard
B
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016547:Kinesins; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D008869:Microtubule-Associated Proteins; D016547:Kinesins