Delayed exercise-induced protection against arrhythmias in dogs--effect of celecoxib.
A 20-min period of treadmill exercise in dogs, sufficient to increase heart rate by 90-100 beats min(-1), markedly decreases the severity of the life-threatening ventricular arrhythmias that result when, following anaesthesia 24 h later, the left coronary artery is occluded. This protection was unaffected by the administration of the selective cyclooxygenase-2 inhibitor celecoxib (two times 3 mg kg(-1) given intravenously). These results show that prostacyclin, derived from cyclooxygenase-2, plays no role in this pronounced delayed cardioprotection.
Nagy
Orsolya
O
Department of Pharmacology and Pharmacotherapy, University of Szeged, Albert Szent-Györgyi Faculty of Medicine, Dóm tér 12, P.O. Box 427, H-6701 Szeged, Hungary.
Hajnal
Agnes
A
Parratt
James R
JR
Végh
Agnes
A
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology* / Q000517:prevention & control; D000068579:Celecoxib; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011451:Prostaglandin-Endoperoxide Synthases; D011720:Pyrazoles / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*; D013997:Time Factors
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D011720:Pyrazoles; D013449:Sulfonamides; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D000068579:Celecoxib