[Interrelations of morphological parameters in the system of neuroendocrine regulation following longterm morphine administration].
To study the morpho-physiological changes of the nervous and endocrine regulatory systems following long-term influence of morphine hydrochloride, morphometric and correlation analysis of the structural components of the cerebral cortex, hypothalamus, adenohypophysis and thyroid gland was performed. The interrelation between the values of some parameters and the dose of morphine hydrochloride, that caused the tolerance to the drug, was shown. Dose-dependent effect was found in the degree of morphological remodeling of organ components that was demonstrated by the changes in cell and nuclear dimensions, staining properties of cytoplasm, ultrastructural components of thyrocytes, neurons and their processes, hormonal background, the number of the functioning blood capillaries. Interrelations of the morphological parameters are demonstrated by the correlations of different strength and direction.
Chuchkova
N N
NN
Glumova
V A
VA
Cherenkov
I A
IA
Iuminova
N A
NA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance / Q000502:physiology; D005625:Frontal Lobe / Q000187:drug effects / Q000648:ultrastructure; D007031:Hypothalamus / Q000187:drug effects / Q000648:ultrastructure; D009020:Morphine / Q000494:pharmacology*; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000648:ultrastructure; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D013963:Thyroid Hormones / Q000378:metabolism; D013997:Time Factors
D013963:Thyroid Hormones; D009020:Morphine