title: Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase.
abstract: The synthesis and nNOS and eNOS activity of 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-2,5-dimethoxyphenyl)-pyridin-2-ylamines 1-8 are described. These compounds are potent inhibitors of the human nNOS isoform.
authors.affiliation: Pfizer Global Research and Development, Groton, CT 06340, USA.
authors.forename: Deane M
authors.initials: DM
authors.lastname: Nason
authors.forename: Steven D
authors.initials: SD
authors.lastname: Heck
authors.forename: Mathew S
authors.initials: MS
authors.lastname: Bodenstein
authors.forename: John A
authors.initials: JA
authors.lastname: Lowe
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nelson
authors.forename: Dane R
authors.initials: DR
authors.lastname: Liston
authors.forename: Charles E
authors.initials: CE
authors.lastname: Nolan
authors.forename: Lorraine F
authors.initials: LF
authors.lastname: Lanyon
authors.forename: Karen M
authors.initials: KM
authors.lastname: Ward
authors.forename: Robert A
authors.initials: RA
authors.lastname: Volkmann
mesh_terms: D000588:Amines / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors*; D009433:Neural Inhibition / Q000187:drug effects; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000588:Amines; D004791:Enzyme Inhibitors; D009419:Nerve Tissue Proteins; D011725:Pyridines; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I