title: Studies on gelatin-based sponges. Part III: a comparative study of cross-linked gelatin/alginate, gelatin/hyaluronate and chitosan/hyaluronate sponges and their application as a wound dressing in full-thickness skin defect of rat.
abstract: Novel cross-linked sponges composed of gelatin/alginate and gelatin/hyaluronate and chitosan/hyaluronate (GH, GA and CH, respectively) were prepared and compared. Six different sponges with or without silver sulfadiazine (AgSD) were applied on the full-thickness dorsal skin defect of Wistar rat. The histology and epidermal wound healing rates of the skin defects were investigated by light microscopy and computerized morphometry 5 and 12 days post-operatively. In our full-thickness wound model (diameter 1 cm), the AgSD-impregnated sponges showed good wound healing performances on the whole. However, there appeared meaningful differences of wound healing between the gelatin-based sponges (GH, GA) and the CH. GH with AgSD was found to show the best wound healing properties as a wound dressing resulting from histological findings and computerized morphometric analysis of epidermal healing.
authors.affiliation: Department of Industrial Chemistry, College of Engineering, Hanyang University, Seoul, South Korea.
authors.forename: Y S
authors.initials: YS
authors.lastname: Choi
authors.forename: S B
authors.initials: SB
authors.lastname: Lee
authors.forename: S R
authors.initials: SR
authors.lastname: Hong
authors.forename: Y M
authors.initials: YM
authors.lastname: Lee
authors.forename: K W
authors.initials: KW
authors.lastname: Song
authors.forename: M H
authors.initials: MH
authors.lastname: Park