Clathrin: now you see me, now you don't!
Endocytic clathrin-coated vesicles are short-lived transport intermediates that ferry cargo macromolecules rapidly into the cell interior. Recent work from the Kirchhausen laboratory indicates that the lifetime of a coated vesicle is extremely short, and assembly of nascent coats aborts abruptly unless reinforced by additional regulatory inputs, most likely cargo capture.
Keyel
Peter A
PA
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA.
Traub
Linton M
LM
D033962:Adaptor Protein Complex 2 / Q000378:metabolism; D000818:Animals; D002966:Clathrin / Q000737:chemistry / Q000502:physiology*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D004705:Endocytosis; D008853:Microscopy; D018613:Microscopy, Confocal; D008854:Microscopy, Electron; D008954:Models, Biological; D011485:Protein Binding
D033962:Adaptor Protein Complex 2; D002966:Clathrin