title: Clinical significance of uterine artery blood flow velocity waveforms during provoked uterine contractions in high-risk pregnancy.
abstract: OBJECTIVE
  To determine whether, in a group of high-risk pregnancies undergoing an oxytocin challenge test (OCT), uterine artery Doppler velocimetry will identify fetuses at risk of distress during the provoked contractions.
  
  
  METHODS
  Bilateral uterine artery Doppler velocimetry was performed simultaneously with electronic fetal heart rate (FHR) recordings in 67 high-risk pregnancies subjected to an OCT. Flow velocity waveforms (FVWs) were classified according to pulsatility index (PI), presence of diastolic notching and a novel classification of FVW shapes. The OCT was classified as negative (normal) or positive (late FHR decelerations). Only OCT-negative cases were allowed a trial of vaginal delivery. Non-parametric statistical methods were used to test for differences between the OCT groups.
  
  
  RESULTS
  There was no difference in prevalence of high PI or diastolic notching in OCT-positive (n = 10) and OCT-negative (n = 57) cases at basal (resting) measurements or between uterine contractions in either uterine artery (P > or = 0.3). During contractions the PI could not be used for assessment due to the biphasic shape of the FVWs, but there was no difference in distribution of FVW classes between the groups in either the placental side (P > or = 0.3) or contraplacental side (P > or = 0.6) uterine artery. No significant associations between PI or FVW class distribution and birth asphyxia or operative delivery for fetal distress in labor were found (P > or = 0.1).
  
  
  CONCLUSIONS
  During uterine contractions there is no difference in uterine artery FVW pattern between OCT-positive and OCT-negative cases. Recording of uterine artery FVWs during the OCT seems to be of limited clinical relevance.
authors.affiliation: Department of Obstetrics and Gynecology, Malmö University Hospital, University of Lund, Malmö, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Gudmundsson
authors.forename: P
authors.initials: P
authors.lastname: Olofsson
mesh_terms: D001158:Arteries; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D005316:Fetal Distress / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D017078:Laser-Doppler Flowmetry; D010121:Oxytocin; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D016216:Ultrasonography, Prenatal; D014590:Uterine Contraction / Q000502:physiology*; D014599:Uterus / Q000098:blood supply*
chemical_list: D010121:Oxytocin