[An experimental study on distribution of musk into the brain through blood brain barrier].
OBJECTIVE
To study the possible pathway of the effect of musk on brain disorder, distributing into the brain through blood brain barrier.


METHODS
We used the musk ketone (muscone), a main composition of musk, to inject through the tail vein of the rats into the blood and took the brain and other organs at different times to make samples. Then gas chromatography was used to measure the distribution of muscone in the brain and other organs.


RESULTS
Muscone could pass through the normal rat's blood brain barrier into the brain and soon reached the highest peak and remained in higher concentration, and more slowly metabolized as compared with other organs.


CONCLUSIONS
Musk distributing into the brain through blood brain barrier provides the basis for its effect in treating brain disorders. Chromatography is an effective method to study the active composition of Chinese herbal medicine distributing through the blood brain barrier into the brain.
Chen
Wen-Kai
WK
Division of Zang-fu Organs' Research, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China. cwenkai@public1.ptt.js.cn
Huang
Yu-Fang
YF
Wang
Hai-Dong
HD
D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002849:Chromatography, Gas; D003516:Cycloparaffins / Q000493:pharmacokinetics; D005229:Fatty Acids, Monounsaturated / Q000493:pharmacokinetics*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D003516:Cycloparaffins; D005229:Fatty Acids, Monounsaturated; C008563:musk; C031021:muscone