Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy.
The three goals of this article are (1) to delineate the limitations in determining the actual incidence of antiepileptic drug (AED) psychiatric and behavioral side effects; (2) to summarize existing data on the direct effects of AEDs on psychiatric and behavioral comorbidities and examine the relationship between these direct effects and specific AED mechanisms of action; and (3) to recognize the indirect effects of AEDs on psychiatric and behavioral medications that can result in aggravation of these comorbidities through drug-drug interactions. All of these data are then combined and formatted into a practical algorithm useful in many clinical situations.
Glauser
Tracy A
TA
Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. glauser@cchmc.org
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D001526:Behavioral Symptoms / Q000188:drug therapy / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000453:epidemiology*
D000927:Anticonvulsants