Papillon-Lefèvre syndrome: case report and review of the literature.
A 15-year-old boy presented with symmetric, well-demarcated, yellowish, keratotic plaques over the skin of his palms and soles extending onto the dorsal surfaces. Well-circumscribed, psoriasiform, erythematous, scaly plaques were also present on the elbows and knees bilaterally along with dystrophy an transverse grooving of the nails. He also had swollen and friable gums since the age of 3 with subsequent loss of most of his permanent dentition. These findings are consistent with Papillon-Lefèvre syndrome. The clinical presentation, differential diagnosis, complications and management of this syndrome are discussed.
Janjua
Shahbaz A
SA
Ayza Skin and Research Center, Lalamusa, Pakistan.
Khachemoune
Amor
A
D000293:Adolescent; D019090:Case Management; D020789:Cathepsin C / Q000235:genetics; D003241:Consanguinity; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D010214:Papillon-Lefevre Disease / Q000175:diagnosis* / Q000235:genetics
D020789:Cathepsin C