[The changes of Oddi sphincter motility after canine pancreas transplantation with bladder drainage].
OBJECTIVE
To study the changes of canine Oddi sphincter (SO) function after pancreas transplantation with bladder drainage and the effect on the graft function.


METHODS
Normal canine SO, transplant canine SO and canine SO in vitro manometry were performed by triple lumen catheter. At the same time, pancreas endocrine and exocrine function after transplantation were determined. After transplantation, anti-reflux function of graft SO was also measured.


RESULTS
Endocrine and exocrine function of all the transplanted dogs showed that pancreas graft function was good. Basal pressure of SO in control group was (18.5 +/- 2.8) mm Hg (1 mm Hg = 0.133 kPa). The contraction frequency was (9.7 +/- 1.5) per min, the contraction amplitude was (47.1 +/- 5.5) mm Hg, the motility index was (236 +/- 56). After transplantation, basal pressure increased to (27.8 +/- 2.8) mm Hg, frequency increased to (13.1 +/- 1.9) per min, amplitude decreased significantly to (8.3 +/- 1.8) mm Hg. There was no significant difference of motility index. Basal pressure of SO in vitro increased significantly to (37.2 +/- 5.1) mm Hg. Phasic contraction was not absent. After transplantation, the pressure in the bile duct residual did not increase in accordance with the increase of bladder pressure.


CONCLUSIONS
After pancreas transplantation with bladder drainage, Basal pressure and frequency of canine SO could increase while amplitude could decrease, which provide the anti-reflux function of graft SO and may serve as an obstacle to pancreatic juice flow.
Li
Gui-Chen
GC
Department of Transplantation, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Yuan
Chun-Hui
CH
Cheng
Ying
Y
Liu
Yong-Feng
YF
D000818:Animals; D004285:Dogs; D004322:Drainage / Q000379:methods*; D005260:Female; D008297:Male; D016035:Pancreas Transplantation / Q000379:methods* / Q000502:physiology; D010189:Pancreatic Juice / Q000378:metabolism; D009803:Sphincter of Oddi / Q000502:physiology*; D014184:Transplantation, Homologous; D001743:Urinary Bladder / Q000601:surgery