On the phase diagram of reentrant condensation in polyelectrolyte-liposome complexation.
Complexation of polyions with oppositely charged spherical liposomes has been investigated by means of dynamic light scattering measurements and a well-defined reentrant condensation has been observed. The phase diagram of charge inversion, recently derived [T. T. Nguyen and B. I. Shklovskii, J. Chem. Phys. 115, 7298 (2001)] for the complexation of DNA with charged spherical macroions, has been employed in order to define the boundaries of the region where polyion-liposome complexes begin to condense, forming larger aggregates, and where aggregates dissolve again, towards isolated polyion-coated-liposome complexes. A reasonable good agreement is observed in the case of complexes formed by negatively charged polyacrylate sodium salt polyions and liposomes built up by cationic lipids (dioleoyltrimethylammoniumpropane), in an extended liposome concentration range.
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Dipartimento di Fisica, Universita' di Roma "La Sapienza" Piazzale A. Moro 5, I-00185 Rome, ItalyIstituto Nazionale per la Fisica della Materia (INFM-CRS SOFT), Unita' di Roma1, Rome, Italy.
Bordi
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Cametti
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D003102:Colloids / Q000737:chemistry*; D003198:Computer Simulation; D004573:Electrolytes / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D044367:Phase Transition; D055672:Static Electricity; D013499:Surface Properties
D003102:Colloids; D004573:Electrolytes; D008081:Liposomes; D008563:Membrane Lipids