[Detection of coagulation factor V in patients with severe hepatitis and its clinical significance].
BACKGROUND
To investigate the prognostic significance and role of coagulation factor V (CFV) levels in clinical diagnostic criteria for severe hepatitis.


METHODS
The CFV level and prothrombin activity (PTA) were tested by turbidimetry for 129 times in 58 patients with severe hepatitis. Comparative studies and clinical significance of CFV and PTA were analyzed by SPSS and SDAS softwares.


RESULTS
1. The levels of CFV and PTA were 15.3%+/-9.7% and 23.5%+/-10.0%, respectively, at the onset of severe hepatitis. 2. The mortality of severe hepatitis gradually increased with the gradual decrease of CFV or PTA during the most severe stage of the illness (P=0.000). 3. The levels of CFV and PTA decreased continually and rapidly in patients who died but gradually increased in survivors. The decrease or increase of PTA preceded that of CFV on the exacerbation or convalescent stage. 4. Hepatic encephalopathy occurred in 14 cases (24.14%). In 10 cases, it occurred in the terminal stage of the illness, far later than the time of the decrease of CFV. 5. The level of CFV was closely related to PTA (the correlation coefficient was 0.812), the level of CFV was almost consistent with that of PTA.


CONCLUSIONS
1. The level of CFV is an important prognostic indicator in severe hepatitis and is more specific than PTA. 2. Simultaneous determination of CFV and PTA may be helpful in earlier and more accurate diagnosis of severe hepatitis. 3. Possible use of CFV as one of the criteria for liver transplantation in patients with severe hepatitis should be studied.
Zou
Zheng-sheng
ZS
The No. 302 Hospital of PLA, Beijing 100039, China.
Liu
Zhi-guo
ZG
Chen
Ju-mei
JM
Xing
Han-qian
HQ
Mao
Yuan-li
YL
Li
Bao-sen
BS
Xin
Shao-jie
SJ
You
Shao-li
SL
Rong
Yi-hui
YH
D000328:Adult; D000368:Aged; D019937:Diagnostic Techniques and Procedures; D005165:Factor V / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006505:Hepatitis / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D011379:Prognosis; D011516:Prothrombin / Q000032:analysis / Q000378:metabolism; D055815:Young Adult
D005165:Factor V; D011516:Prothrombin