Renovascular hypertension due to antithrombin deficiency in childhood.
Inherited antithrombin deficiency generally causes a predisposition toward vascular thrombus above the age of 15 years. A 1-year-old boy developed renal hypertension caused by renal artery obstruction due to thrombus formation. This thrombus formation was attributed to antithrombin deficiency caused by a novel SERPINCI gene mutation (AT III Akita, M352R). This suggests that antithrombin deficiency can cause renal artery obstruction, inducing renal hypertension through vascular thrombosis even in children.
Miura
Kaori
K
Department of Pediatrics, Akita University School of Medicine, Akita, Japan.
Takahashi
Tsutomu
T
Takahashi
Ikuko
I
Komatsu
Masaki
M
Tsuchida
Satoko
S
Mikami
Tamaki
T
Suzuki
Takashi
T
Takahashi
Satoshi
S
Takada
Goro
G
D020152:Antithrombin III Deficiency / Q000150:complications* / Q000235:genetics*; D006801:Humans; D006978:Hypertension, Renovascular / Q000235:genetics*; D007223:Infant; D008297:Male; D009154:Mutation; D012078:Renal Artery Obstruction / Q000209:etiology* / Q000235:genetics; D015843:Serpins / Q000235:genetics; D013927:Thrombosis / Q000235:genetics*
D015843:Serpins