title: Adrenomedullin as a sensitive marker for coronary and peripheral arterial complications in patients with atherosclerotic risks.
abstract: Plasma adrenomedullin (AM) levels are elevated in various pathological states including cardiovascular and inflammatory diseases. The present study investigated whether an increased AM level is a marker of vascular complications in patients with atherosclerotic risks. In 114 patients with cardiovascular risks and/or diseases including ischemic heart disease (IHD) and peripheral arterial disease (PAD), plasma AM concentration and other inflammatory markers such as high sensitive C-reactive protein (CRP) and interleukin (IL)-6 were examined. The plasma AM level was not altered by the absence or presence of each of four major risk factors, i.e., hypertension, diabetes mellitus, hyperlipidemia, and smoking and its level was not significantly correlated with blood pressure, plasma glucose, or serum lipid levels. The patients with IHD had a significantly higher concentration of plasma AM than those without IHD. The AM level in subjects with PAD was also increased significantly compared with those without PAD. The plasma AM was strongly correlated with inflammatory parameters such as CRP and IL-6. Among AM, CRP, and IL-6, however, only AM was an independent predictor for both IHD and PAD by multiple logistic regression analysis. Our findings suggest the possibility that plasma AM is a novel sensitive marker for the presence of vascular lesions in patients with atherosclerotic risks.
authors.affiliation: Department of Medicine, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita, Osaka 565-8565, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Horio
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nonogi
authors.forename: Tokio
authors.initials: T
authors.lastname: Hayashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitamura
authors.forename: Tanenao
authors.initials: T
authors.lastname: Eto
authors.forename: Kenji
authors.initials: K
authors.lastname: Kangawa
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D053607:Adrenomedullin; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D001161:Arteriosclerosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D010455:Peptides / Q000097:blood*; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D010455:Peptides; D053607:Adrenomedullin