title: Argatroban usage for anticoagulation for ECMO on a post-cardiac patient with heparin-induced thrombocytopenia.
abstract: We report a post-Norwood Stage I patient requiring ECMO support using Argatroban as an anticoagulant following diagnosis of heparin-induced thrombocytopenia (HIT). A 2.6 kg female was born with hypoplastic left heart syndrome and underwent a Norwood Stage I operation on day 4 of life. The patient weaned off cardiopulmonary bypass with no complications and was routinely placed on a ventricular assist device (VAD) for 3 days. Heparin was infused at a rate of 16-32 IU/ kg/h to maintain an ACT of 160-180 seconds. Two days after VAD termination, the patient was placed on continuous veno-veno hemofiltration (CVVH). Shortly after CVVH, the patient was diagnosed with HIT and placed on an Argatroban infusion. Five days later, a VAD and subsequent ECMO was used because of decreasing left ventricular function, gross body edema, and poor renal function. This case report summarizes the use of Argatroban during VAD and ECMO support for a patient diagnosed with HIT.
authors.affiliation: Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon 97239, USA. mejakb@ohsu.edu
authors.forename: Brian
authors.initials: B
authors.lastname: Mejak
authors.forename: Carmen
authors.initials: C
authors.lastname: Giacomuzzi
authors.forename: Eileen
authors.initials: E
authors.lastname: Heller
authors.forename: Xiaomang
authors.initials: X
authors.lastname: You
authors.forename: Ross
authors.initials: R
authors.lastname: Ungerleider
authors.forename: Irving
authors.initials: I
authors.lastname: Shen
authors.forename: Lynn
authors.initials: L
authors.lastname: Boshkov
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D001120:Arginine / Q000031:analogs & derivatives; D001777:Blood Coagulation / Q000187:drug effects*; D002315:Cardiopulmonary Bypass; D015199:Extracorporeal Membrane Oxygenation; D017809:Fatal Outcome; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000601:surgery; D007231:Infant, Newborn; D010875:Pipecolic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D011182:Postoperative Care; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban