[Effect of topical application of a Rho-kinase inhibitor on the erectile response in rats].
OBJECTIVE
To investigate the effect of Rho-kinase inhibitor applied topically on the penile erection and systemic circulation of rats.


METHODS
Y-27632 was applied to the surface of the tunica albuginea or to the penile skin of rats, and the changes of CCP/MAP were observed continuously.


RESULTS
Both methods of drug administration resulted in a marked increase in the erectile response both with and without stimulation of the innervation of the penile vasculature. Some doses of the drug were also found to reduce systemic blood pressure.


CONCLUSIONS
Inhibitors of Rho-kinase may represent a new and promising method of treatment for erectile dysfunction.
Dai
Yutian
Y
Department of Urology, the Affiliated Drum Tower Hospital of Nanjing University Medical College, Nanjing, Jiangsu 210008, China. ytdai@hotmail.com
Sun
Zeyu
Z
Chitaley
Kanchan
K
Webb
R Clinton
RC
Mills
Thomas M
TM
Lewis
Ronald W
RW
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000577:Amides; D004791:Enzyme Inhibitors; D011725:Pyridines; C108830:Y 27632