title: [Use of therapeutic polycomponent vaccine "Immunovac VP-4" for the treatment of chronic bacterial prostatitis].
abstract: A complex of clinical and laboratory examinations of patients with bacterial chronic prostatitis was carried out. The patients were divided into two groups: 55 patients treated by the method of immunotherapy and 20 patients (controls) undergoing basic therapy. Immunotherapy was carried out with the use of polycomponent vaccine VP-4 containing Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris and Escherichia coli antigens. Vaccinal therapy was indicated in cases with infection focus associated with opportunistic bacteria, a prolonged torpid course of prostatitis and when different schemes of etiotropic therapy proved to be ineffective. The vaccine was introduced in 4 or 5 subcutaneous injections at an interval of 5-7 days. The study revealed that in cases of chronic prostatitis accompanied by microecological and immune disturbances the use of complex therapy allowed to achieve good clinical and laboratory results in 91% of the patients. In the patients undergoing immunotherapy the elimination of opportunistic bacteria from the urogenital tract and the restoration of affected microflora occurred.
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
authors.forename: A E
authors.initials: AE
authors.lastname: Vershinin
authors.forename: V M
authors.initials: VM
authors.lastname: Kucherskiĭ
authors.forename: V G
authors.initials: VG
authors.lastname: Mitkov
authors.forename: N E
authors.initials: NE
authors.lastname: Klimova
authors.forename: E A
authors.initials: EA
authors.lastname: Kurbatova
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
mesh_terms: D000328:Adult; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004926:Escherichia coli / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D016233:Immunotherapy, Active; D007279:Injections, Subcutaneous; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000382:microbiology; D011472:Prostatitis / Q000382:microbiology / Q000628:therapy*; D011514:Proteus vulgaris / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D017778:Vaccines, Combined; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined; D022223:Vaccines, Subunit