[The modulating action of amino acids upon development in an organotypic culture].
The effect of L-amino acids in concentration 0.05 ng/ml was investigated in organotypic tissue culture of spleen, liver and brain cortex at the age of 1 and 21 days. The high molecular and low hydrophobic amino acids: asparagin, lysine, arginine, and glutamine, are active inducing both a less intensive growth zone in explants of all three tissue types in 1-day old rats and more intensive growth zone in spleen, liver explants in 21-day rats as compared to control. Another group of low molecular and high hydrophobic amino acids is active inducing a more intensive growth zone in brain cortex explant in 21-day rats, as compared to control. The data obtained suggest a modulating role of amino acids in the tissues at different stages of maturation.
Chalisova
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Penniiaĭnen
V A
VA
D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000601:Amino Acids, Essential / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D057927:Hydrophobic and Hydrophilic Interactions; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D008970:Molecular Weight; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D013237:Stereoisomerism; D046509:Tissue Culture Techniques
D000596:Amino Acids; D000601:Amino Acids, Essential