Histopathologic confirmation of complete cancer-cell kill in excised specimens after renal cryotherapy.
We present the first case of complete documentation of total cancer ablation in a previously cryoablated human renal tumor. A 61-year-old patient with metachronous bilateral renal cell carcinoma was treated with open partial nephrectomy and subsequently laparoscopic cryoablation. His renal function deteriorated, prompting bilateral radical nephrectomy before renal transplantation. Detailed histopathologic examination of the specimen did not reveal any evidence of malignancy in two cryoablated sites 36 months (left kidney) and 19 months (right kidney) after the respective cryoablations.
Lin
Chia-Hsiang
CH
Section of Laparoscopic and Minimally Invasive Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Moinzadeh
Alireza
A
Ramani
Anup P
AP
Gill
Inderbir S
IS
D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery*; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery*; D003452:Cryosurgery; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation; D010535:Laparoscopy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000601:surgery*; D009392:Nephrectomy; D012074:Remission Induction; D018239:Seminoma / Q000628:therapy; D013736:Testicular Neoplasms / Q000628:therapy