title: Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias.
abstract: Novel hybrids of lipoic acid and trolox connected through triamine spacers as well as analogues in which the lipoic acid was attached at different positions of the chroman moiety of vitamin E through an amide bond, were synthesized and exhibited strong inhibition of the microsomal lipid peroxidation. Moreover, the new molecules, at 1 microM concentration, reduced reperfusion arrhythmias and MDA content on isolated rat heart preparations, with the 2- and 5-subtituted chromans possessing the better cardioprotective activity.
authors.affiliation: Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vasileos Constantinou Avenue, 116 35 Athens, Greece. mkoufa@eie.gr
authors.forename: Maria
authors.initials: M
authors.lastname: Koufaki
authors.forename: Anastasia
authors.initials: A
authors.lastname: Detsi
authors.forename: Elissavet
authors.initials: E
authors.lastname: Theodorou
authors.forename: Christina
authors.initials: C
authors.lastname: Kiziridi
authors.forename: Theodora
authors.initials: T
authors.lastname: Calogeropoulou
authors.forename: Athanasios
authors.initials: A
authors.lastname: Vassilopoulos
authors.forename: Angeliki P
authors.initials: AP
authors.lastname: Kourounakis
authors.forename: Eleni
authors.initials: E
authors.lastname: Rekka
authors.forename: Panos N
authors.initials: PN
authors.lastname: Kourounakis
authors.forename: Catherine
authors.initials: C
authors.lastname: Gaitanaki
authors.forename: Panagiota
authors.initials: P
authors.lastname: Papazafiri
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000378:metabolism; D002839:Chromans / Q000138:chemical synthesis* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D002839:Chromans; D008063:Thioctic Acid