title: An integrated comprehensive workbench for inferring genetic networks: voyagene.
abstract: We propose an integrated, comprehensive network-inferring system for genetic interactions, named VoyaGene, which can analyze experimentally observed expression profiles by using and combining the following five independent inferring models: Clustering, Threshold-Test, Bayesian, multi-level digraph and S-system models. Since VoyaGene also has effective tools for visualizing the inferred results, researchers may evaluate the combination of appropriate inferring models, and can construct a genetic network to an accuracy that is beyond the reach of a single inferring model. Through the use of VoyaGene, the present study demonstrates the effectiveness of combining different inferring models.
authors.affiliation: Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. maki@brs.kyushu-u.ac.jp
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Maki
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Arikawa
authors.forename: Shoji
authors.initials: S
authors.lastname: Watanabe
authors.forename: Ken
authors.initials: K
authors.lastname: Aoshima
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Eguchi
authors.forename: Takanori
authors.initials: T
authors.lastname: Ueda
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Aburatani
authors.forename: Satoru
authors.initials: S
authors.lastname: Kuhara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okamoto
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D003196:Computer Graphics; D003198:Computer Simulation; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000502:physiology*; D008957:Models, Genetic; D015233:Models, Statistical; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology*; D012984:Software; D018511:Systems Integration; D014584:User-Computer Interface