Isolation and structure elucidation of azoricasterol, a new sterol of the deepwater sponge Macandrewia azorica.
Chemical investigation of the deepwater sponge Macandrewia azorica, collected from the flanks of the Gettysburg and Ormonde Sea Mount, North Atlantic, from a depth of 600 m, has led to the isolation of a new sterol with an unusual side chain (1), along with S-methylergothioneine (2). The structures of compounds 1 and 2 were established by employing spectroscopic techniques (NMR, MS, UV, IR and polarimetry). This is the first report of metabolites of a sponge belonging to the genus Macandrewia.
Gross
Harald
H
Pharmazeutische Biologie, Universität Bonn, Nussallee 6, 53115 Bonn, Germany.
Reitner
Joachim
J
König
Gabriele M
GM
D000818:Animals; D011161:Porifera / Q000737:chemistry*; D012623:Seawater; D013261:Sterols / Q000032:analysis* / Q000737:chemistry
D013261:Sterols; C493891:azoricasterol