[Physicochemical and immune properties of glycoglycerolipids from Laminaria japonica within immunostimulating complexes (ISCOMs)].
Certain physicochemical properties of glycoglycerolipids from marine alga Laminaria japonica (monogalactosyl diacylglycerol, digalactosyl diacylglycerol, and sulfoquinovosyl diacylglycerol) and their ability to be incorporated into immunostimulating complexes (ISCOMs) used for presentation of microbial and tumor antigens in vesicular form were comparatively described. These glycolipids proved to considerably differ by fatty acid composition, degree of unsaturation, and phase transition temperature. Possible production of modified ISCOMs through incorporation of these glycolipids into the vesicle instead of the glycolipid component was demonstrated. Preliminary data demonstrated no significant increase in immune response to Yersinia pseudotuberculosis porin within the modified (with monogalactosyl diacylglycerol) and classical (with phosphatidylcholine) ISCOMs as compared to individual porin.
Li
I A
IA
Popov
A M
AM
Sanina
N M
NM
Kostetskiĭ
E Ia
EIa
Novikova
O D
OD
Reunov
A V
AV
Nagorskaia
V P
VP
Portniagina
O Iu
OIu
Khomenko
V A
VA
Shnyrov
V L
VL
D000818:Animals; D038983:Galactolipids / Q000737:chemistry; D006017:Glycolipids / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D016882:ISCOMs / Q000737:chemistry / Q000276:immunology*; D007114:Immunization; D007795:Laminaria / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D046529:Microscopy, Electron, Transmission; D044367:Phase Transition; D010713:Phosphatidylcholines / Q000737:chemistry; D018272:Porins / Q000737:chemistry / Q000276:immunology / Q000302:isolation & purification; D015011:Yersinia pseudotuberculosis / Q000737:chemistry
D038983:Galactolipids; D006017:Glycolipids; D016882:ISCOMs; D010713:Phosphatidylcholines; D018272:Porins; C015903:glycerolglycolipids; C009909:monogalactosyldiacylglycerol