title: Effects of mechanical load on flow, volume and pressure delivered by high-frequency percussive ventilation.
abstract: High-frequency percussive ventilation (HFPV) has proved its unique efficacy in the treatment of acute respiratory distress, when conventional mechanical ventilation (CMV) has demonstrated a limited response. We analysed flow (V(dot)), volume (V) and airway pressure (Paw) during ventilation of a single-compartment mechanical lung simulator, in which resistance (R) and elastance (E) values were modified, while maintaining the selected ventilatory settings of the HFPV device. These signals reveal the physical effect of the imposed loads on the output of the ventilatory device, secondary to constant (millisecond by millisecond) alterations in pulmonary dynamics. V(dot), V and Paw values depended fundamentally on the value of R, but their shapes were modified by R and E. Although peak Paw increased 70.3% in relation to control value, mean Paw augmented solely 36.5% under the same circumstances (maximum of 9.4 cm H2O). Finally, a mechanism for washing gas out of the lung was suggested.
authors.affiliation: Department of Perioperative Medicine, Intensive Care and Emergency, Cattinara Hospital, Trieste University School of Medicine, Strada di Fiume 447, I-34139, Italy. u.lucangelo@fmc.units.it
authors.forename: U
authors.initials: U
authors.lastname: Lucangelo
authors.forename: V
authors.initials: V
authors.lastname: Antonaglia
authors.forename: W A
authors.initials: WA
authors.lastname: Zin
authors.forename: L
authors.initials: L
authors.lastname: Fontanesi
authors.forename: A
authors.initials: A
authors.lastname: Peratoner
authors.forename: F M
authors.initials: FM
authors.lastname: Bird
authors.forename: A
authors.initials: A
authors.lastname: Gullo
mesh_terms: D000403:Airway Resistance / Q000502:physiology*; D006612:High-Frequency Ventilation / Q000379:methods*; D006801:Humans; D008168:Lung / Q000502:physiology*; D008176:Lung Volume Measurements; D012123:Pulmonary Ventilation / Q000502:physiology*; D012119:Respiration; D012121:Respiration, Artificial; D013990:Tidal Volume / Q000502:physiology*