Medallion-like dermal dendrocyte hamartoma: a new clinically and histopathologically distinct lesion.
Dermal dendrocyte hamartomas are extremely rare; only two examples have been described with clinical features different from our cases and with incomplete immunohistochemical characterization. We report three female patients presenting a medallion-shaped, well-defined, slightly atrophic and asymptomatic congenital lesion. All 3 patients showed a fusiform-cell proliferation. Immunohistochemistry was positive for CD34, factor XIIIa, and fascin. Electron microscopy showed typical features of dermal dendrocytes. We believe that the lesions described represent a new, clinically and histopathologically distinct lesion originating in dermal dendrocytes. We propose to name it medallion-like dermal dendrocyte hamartoma.
Rodríguez-Jurado
Rodolfo
R
Department of Pathology, National Institute of Pediatrics, Mexico.
Palacios
Carolina
C
Durán-McKinster
Carola
C
Mercadillo
Patricia
P
Orozco-Covarrubias
Luz
L
Saez-de-Ocariz
Maria del Mar
Mdel M
Ruiz-Maldonado
Ramón
R
D018952:Antigens, CD34 / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D026122:Factor XIIIa / Q000032:analysis; D005260:Female; D006222:Hamartoma / Q000145:classification / Q000151:congenital / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008840:Microfilament Proteins / Q000032:analysis; D008854:Microscopy, Electron; D009455:Neurofibroma / Q000175:diagnosis; D012871:Skin Diseases / Q000145:classification / Q000151:congenital / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D018952:Antigens, CD34; D002352:Carrier Proteins; D008840:Microfilament Proteins; D014746:Vimentin; C020324:fascin; D026122:Factor XIIIa