title: Transperineal in vivo fluence-rate dosimetry in the canine prostate during SnET2-mediated PDT.
abstract: Advances in photodynamic therapy (PDT) treatment for prostate cancer can be achieved either by improving selectivity of the photosensitizer towards prostate gland tissue or improving the dosimetry by means of individualized treatment planning using currently available photosensitizers. The latter approach requires the ability to measure, among other parameters, the fluence rate at different positions within the prostate and the ability to derive the tissue optical properties. Here fibre optic probes are presented capable of measuring the fluence rate throughout large tissue volumes and a method to derive the tissue optical properties for different volumes of the prostate. The responsivity of the sensors is sufficient to detect a fluence rate of 0.1 mW cm(-2). The effective attenuation coefficient in the canine prostate at 660 nm is higher at the capsule (2.15+/-0.19 cm(-1)) than in proximity of the urethra (1.84+/-0.36 cm(-1)). Significant spatial and temporal intra- and inter-canine variability in the tissue optical properties was noted, highlighting the need for individualized monitoring of the fluence rate for improved dosimetry.
authors.affiliation: Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada. llilge@uhnres.utoronto.ca
authors.forename: Lothar
authors.initials: L
authors.lastname: Lilge
authors.forename: Natalie
authors.initials: N
authors.lastname: Pomerleau-Dalcourt
authors.forename: Alexander
authors.initials: A
authors.lastname: Douplik
authors.forename: Steven H
authors.initials: SH
authors.lastname: Selman
authors.forename: Rick W
authors.initials: RW
authors.lastname: Keck
authors.forename: Maria
authors.initials: M
authors.lastname: Szkudlarek
authors.forename: Maciej
authors.initials: M
authors.lastname: Pestka
authors.forename: Jerzy
authors.initials: J
authors.lastname: Jankun
mesh_terms: D000465:Algorithms; D000818:Animals; D004285:Dogs; D008027:Light; D008297:Male; D015233:Models, Statistical; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology; D011166:Porphyrins / Q000494:pharmacology; D011467:Prostate / Q000528:radiation effects*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011874:Radiometry / Q000379:methods*; D013997:Time Factors
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; C063166:tin etiopurpurin