title: Layer-specific potentiation of evoked IPSCs in rat hippocampal CA1 pyramidal cells by lanthanum.
abstract: Lanthanum (La3+) potentiates or depresses GABAA receptors (GABAAR) in a subunit-dependent manner. Such differential modulators may help to discriminate between-layer-specific inhibitory synaptic inputs to individual neurons, which use different molecular GABAAR isoforms. Here, we show that inhibitory postsynaptic currents (IPSCs) in CA1 pyramidal cells are potentiated by La3+ (100 microM) when they are evoked by stimulation in stratum oriens. In contrast, stimulation in stratum radiatum yields IPSCs which are not sensitive towards La3+. These data point towards an input-specific molecular and functional diversity of inhibitory synapses at CA1 pyramidal cells.
authors.affiliation: Brain Research Institute, Moscow, Russia.
authors.forename: M B
authors.initials: MB
authors.lastname: Kozhemiakin
authors.forename: A
authors.initials: A
authors.lastname: Draguhn
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitsky
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects* / Q000528:radiation effects; D006624:Hippocampus / Q000166:cytology* / Q000528:radiation effects; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects*; D018408:Patch-Clamp Techniques / Q000379:methods; D017966:Pyramidal Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects / Q000528:radiation effects
chemical_list: D007811:Lanthanum