title: Screening of oxazepine indole enantiomers by means of high performance liquid chromatography with imprinted polymer stationary phase.
abstract: Chromatographic enantiomer separations of different oxazepine indole derivatives were performed using a molecularly imprinted polymer. A 5aR,12R,13S-trans-6,6-dimethyl-12,13-dihydro-6H-5a, 1 3-methanoindolo[2,1-b][1,3]naphthoxazepine-12-carboxamide enantiomerderivative was used as a template and the resultant polymer has shown enantiomer recognition for series of template related compounds. The mechanistic description of the chiral discrimination process is scrutinised, comparing the discrimination between the different conformations and substituents of the oxazepine indoles.
authors.affiliation: Dept. of Chemistry, Vytautas Magnus University, Vileikos 8, LT-44404 Kaunas, Lithuania.
authors.forename: Egidijus
authors.initials: E
authors.lastname: Machtejevas
authors.forename: Börje
authors.initials: B
authors.lastname: Sellergren
authors.forename: Vytas
authors.initials: V
authors.lastname: Martynaitis
authors.forename: Paul K
authors.initials: PK
authors.lastname: Owens
authors.forename: Audrius
authors.initials: A
authors.lastname: Maruska
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007202:Indicators and Reagents; D008958:Models, Molecular; D010077:Oxazepines / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D007202:Indicators and Reagents; D010077:Oxazepines