Relationship between endoscopic nodular gastritis and Helicobacter pylori infection in children.
BACKGROUND
The specificity of relationship of endoscopic evidence of nodular gastritis with Helicobacter pylori infection is unclear.


OBJECTIVE
To assess the relationship of endoscopic nodular gastritis and H. pylori infection among children.


METHODS
124 children (median age 8.2 years, range 1-15) undergoing upper GI endoscopy for abdominal pain underwent urease test and histological examination of gastric mucosa to determine the presence and density of H. pylori infection, and presence and severity of gastritis.


RESULTS
H. pylori infection was detected in 57 (46%) children. Endoscopic nodular gastritis was present in 46 of these 57 patients (81%) and in 24 of 67 (36%) H. pylori-negative patients (36%). The frequency of endoscopic nodular gastritis was related to increasing age (p< 0.0001), presence of H. pylori, grade of histologic gastritis, and H. pylori density (p< 0.0001).


CONCLUSIONS
Endoscopic finding of nodular gastritis is associated with presence of H. pylori infection and active chronic gastritis in children.
Rafeey
Mandana
M
Division of Gastroenterology, Department of Pediatrics, Tabriz Children Hospital, Tabriz University of Medical Sciences, Tabriz, I. R., Iran. mrafeey@yahoo.com
Jafari Rouhi
Amir Hossein
AH
Gassemi
Bab Allah
BA
Rouhi
Asghar Jafari
AJ
D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D005756:Gastritis / Q000175:diagnosis* / Q000453:epidemiology* / Q000821:virology; D005773:Gastroscopy / Q000379:methods; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D011336:Probability; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017678:Sex Distribution