Genetic regulation of protein synthesis in trypanosomes.
It is becoming increasingly clear that parasitic protozoa remain a scourge to humans in the 21st century. The trypanosomes are a diverse group of insect-transmitted parasites that wiggle their way through multiple life cycle stages as they destroy human lives. Exquisitely detailed studies of these organisms reveal basic differences in gene expression that separate these single celled eukaryotes from multicellular eukaryotic organisms and have suggested numerous potential drug targets.
Das
Anish
A
Department of Microbiology and Molecular genetics, UMDNJ-New Jersey Medical School, International Center for Public Health, Newark, New Jersey 07013, USA.
Bellofatto
Vivian
V
D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005786:Gene Expression Regulation; D017125:Genes, Protozoan; D014644:Genetic Variation; D008958:Models, Molecular; D011401:Promoter Regions, Genetic; D015800:Protozoan Proteins / Q000096:biosynthesis* / Q000235:genetics*; D012313:RNA / Q000096:biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic; D014345:Trypanosoma / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics
D015800:Protozoan Proteins; D012333:RNA, Messenger; D014643:Variant Surface Glycoproteins, Trypanosoma; D012313:RNA; D012321:DNA-Directed RNA Polymerases