title: Multiple primary malignant neoplasms in urologic patients.
abstract: METHODS
  Second primary cancers constitute approximately 9-10% of malignancies diagnosed in the United States. We aimed to show the risk and incidance of second primary tumor occuring associated to urologic tumors and show the distrubution of tumors in Tracia region. We retrospectively examined the patients' files with the diagnosis of malignant disease between the years 1985-2000. Hazard function analysis was performed to estimate the relative risk of secondary malignancy occuring. Age, sex and tumor number were examined to find out if they affect on mortality rate.
  
  
  RESULTS
  A total number of 25 MPMNs were diagnosed. In 52 percent of the cases the second primary neoplasm developed within six months. The relative risk of development of a second neoplasm is found as increasing 1.111 times per month. The incidence of secondary malignancy occuring in the patients with one tumor was found as 6.31%. Age (p < 0.001) and tumor number (p < 0.001) are found as statistically effective predictor on mortality rate where the sex is not.
  
  
  CONCLUSIONS
  In the patients with a primary tumor not only the metastasis must be investigated but also second primary tumors should be taken into consideration.
authors.affiliation: Trakya University Medical Faculty Hospital, Department of Urology, Edirne, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Inci
authors.forename: Esat
authors.initials: E
authors.lastname: Kaya
authors.forename: Bulent
authors.initials: B
authors.lastname: Alagol
authors.forename: Irfan Huseyin
authors.initials: IH
authors.lastname: Atakan
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Aydin
authors.forename: Hasan
authors.initials: H
authors.lastname: Ereselli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Primary; D016016:Proportional Hazards Models; D012307:Risk Factors; D014571:Urologic Neoplasms