[A study on the expression of IL-8 and IL-3 in human nasal polyp and polyposis].
OBJECTIVE
To study the expression of IL-8 and IL-3 in human nasal polyp and polyposis.


METHODS
Using immunohistochemical methods detect the expressions of IL-8 and IL-3 in 52 cases of middle turbinate,nasal polyp and nasal polyposis,and calculating the positive area percentages in each group. All datas were analysed with SNK test, Kruskal-Wallis test and Mann-Whitney test.


RESULTS
There were very significant differences between either two groups about the expressions of IL-8. There were significant differences between either two groups about the expressions of IL-3.


CONCLUSIONS
IL-8 is not only one of the causes in nasal polyp, but also plays an important role in the recurrence of nasal polyposis. The expression of IL-8 in polyp is different from that in polyposis, it indicate that polyp and polyposis have different mechanism. IL-3 is important for the accumulation of eosinophil and is a key factor in the mechanism of polyposis.
Ma
Hongzhi
H
Department of Otorhinolaryngology, the First Clinical Hospital, China Medical University, Shenyang, 110001, China.
Cao
Zhiwei
Z
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000096:biosynthesis*; D016209:Interleukin-8 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology
D007377:Interleukin-3; D016209:Interleukin-8