[Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism].
OBJECTIVE
To study the effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental oral precancerous lesion and its mechanism.


METHODS
We treated the experimental oral precancerous lesion in hamster's cheek pouch using 1023 Recipe (consisting of Radix Astragali, Gynostemma Pentaphyllum, Rhizoma Chuanxiong and selenium-rich green tea) for 6 weeks, and observed its effect in blocking cancer transformation, detected 2 kinds of agglutinin receptors (receptors of wheat germ agglutinin and Ricinus communis agglutinin) in the mucosa of the hamster's cheek pouch.


RESULTS
The rate of cancer transformation in 1023 Recipe treated group was lower than that in the control group without treatment (P<0.05). Agglutinin receptors in the two groups were different significantly.


CONCLUSIONS
1023 Recipe is effective in treating hyperplasia, and can prevent its cancer transformation. The mechanism may be that 1023 Recipe can induce precancerous lesions to differentiate into normal tissues.
Chen
Zuo-Liang
ZL
Xiamen Hospital of Stomatalogy, Xiamen, Fujian Province 361001, China. zuoliangc@yahoo.com.cn
Guan
Yu-Qin
YQ
Chen
Xi
X
Chen
Xiao-Ling
XL
Chen
Jin-Chun
JC
D000373:Agglutinins / Q000378:metabolism; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D006224:Cricetinae; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009369:Neoplasms / Q000473:pathology / Q000517:prevention & control*; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D014909:Wheat Germ Agglutinins / Q000378:metabolism
D000373:Agglutinins; D004365:Drugs, Chinese Herbal; D014909:Wheat Germ Agglutinins