Influence of fluorapatite minor additions on behavior of hydroxyapatite ceramics.
Fluorinated hydroxyapatite is known to be less soluble by body fluids, resulting in enhanced resistance to biodegradation in vivo conditions, as compared to the pure hydroxyapatite ceramics. The present work was aimed at the investigation of the effect of minor additions of ultrafine fluorapatite (up to 10 wt%) on the sintering behavior and mechanical properties of hydroxyapatite ceramics. In vitro testing for the osteoblast-like cells viability and proliferation was performed with the samples of varying fluorapatite content. It was found that the fluorapatite addition hinders the sintering shrinkage and lowers the strength, but does not generally affect negatively the viability of the cells.
Barinov
S M
SM
Institute for Physical Chemistry of Ceramics RAS, Ozernaya 48, 119361, Moscow, Russia. barinov_s@mail.ru
Rustichelli
F
F
Orlovskii
V P
VP
Lodini
A
A
Oscarsson
S
S
Firstov
S A
SA
Tumanov
S V
SV
Millet
P
P
Rosengren
A
A
D001031:Apatites; D001672:Biocompatible Materials; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D002516:Ceramics; D017886:Durapatite; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology; D012995:Solubility
D001031:Apatites; D001672:Biocompatible Materials; D017886:Durapatite; C025105:fluorapatite