[Effect of Zhenju Jiangya Tablet on the endothelial function of hyperlipidemic rabbits].
OBJECTIVE
To study the effect of Zhenju Jiangya Tablet (ZJ) on the injured endothelial cells and endothelium-dependent relaxation function of hyperlipidemia rabbits.


METHODS
Male New Zealand rabbits were randomized into four groups: control group, hyperlipidemia group, ZJ group and sivastatin group. The endothelium-dependent relaxation function was evaluated by APV using intravascular Doppler, and the morphology of endothelial cells was detected by light microscopy and electron microscopy, and nitric oxide synthase was evaluated.


RESULTS
ZJ reduced the lesions of hyperlipidemia vessels, and the APV after Ach injection of each group was (1.14+/-0.26), (1.74+/-0.59), (1.22+/-0.37) and (1.17+/-0.41) respectively. The eNOS of each group was (4.21+/-0.37), (1.43+/-0.88), (3.95+/-0.67) and (4.08+/-0.46) nmol x min(-1) x g(-1) respectively.


CONCLUSIONS
ZJ can improve the abnormality of endothelial cells and endothelium-dependent relaxation function of hyperlipidemia.
Hou
Xu-Min
XM
Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Ni
Huan-Chun
HC
Luo
Xin-Ping
XP
Shi
Hai-Ming
HM
Fan
Wei-Hu
WH
D000818:Animals; D042783:Endothelial Cells / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008055:Lipids / Q000097:blood; D008297:Male; D008516:Medicine, Chinese Traditional; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III; D011817:Rabbits; D013607:Tablets
D008055:Lipids; D013607:Tablets; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III