title: [Effects of granules for nourishing kidney and strengthening brain on main symptoms of kidney-yin deficiency and blood stasis syndrome and hemorrheological characteristics of brain atrophy].
abstract: OBJECTIVE
  To explore the influence of granules for nourishing kidney and strengthening brain (GNKSB) on main symptoms of kidney-yin deficiency and blood stasis syndrome and the hemorrheological characteristics of brain atrophy patients.
  
  
  METHODS
  Ninety patients of brain atrophy with kidney-yin deficiency and blood stasis syndrome were randomly divided into two groups. Sixty cases in treatment group were treated with GNKSB, and the 30 cases in control group were treated with piracetam for 8 weeks.
  
  
  RESULTS
  The effective rate of treatment group was 73.3%, with significant difference as compared with 46.6% of the control group (P<0.01). The scores of symptom-assessment of the two groups were also significantly different (P<0.01). The mini-mental state examination of treatment group was obviously improved, and was significantly different as compared with the control group (P<0.01). The scores of Hasegawa's dementia scale and activities of daily living were increased, but without significant difference as compared with the control group. The platelet aggregation rate was improved, with significant difference as compared with the control group (P<0.05). The whole blood viscosity was also improved obviously, but without significant difference as compared with the control group.
  
  
  CONCLUSIONS
  GNKSB is effective for kidney-yin deficiency and blood stasis syndrome of brain atrophy patients and can improve their mental state and the hemorrheological indexes.
authors.affiliation: Hunan Provincial Academy of of Trditional Chinese Medicine and Chinese Materia Medica, Changsha, Hunan Province 410006, China. zsyyy@21.cn.com
authors.forename: Shen
authors.initials: S
authors.lastname: Zhou
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Yang
authors.forename: You-Sheng
authors.initials: YS
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Da-Hua
authors.initials: DH
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Yang
mesh_terms: D000368:Aged; D001284:Atrophy; D001809:Blood Viscosity / Q000187:drug effects*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D013927:Thrombosis / Q000188:drug therapy*; D016710:Yin Deficiency / Q000188:drug therapy*