Colorimetric tools for solid-phase organic synthesis.
One of the unresolved problems of solid-phase organic synthesis (SPOS) is the availability of general and rapid methods to monitor the transformation of functional groups present in molecules supported on insoluble supports. Color tests, far from providing the ultimate solution, may help in detection (and sometimes in quantification) of different functional groups. In this short review, we have collected most of the methods available and applied in SPOS with an Experimental Section that describes the procedure we have successfully applied to bead analyses in our laboratories.
Gaggini
Francesca
F
CNR, Istituto di Chimica dei Composti Organo Metallici, c/o Dipartimento di Chimica Organica "Ugo Schiff", Polo Scientifico, Università degli Studi di Firenze, Via della Lastruccia, 13, 50019 Sesto Fiorentino, Italy.
Porcheddu
Andrea
A
Reginato
Gianna
G
Rodriquez
Manuela
M
Taddei
Maurizio
M