Topical phenytoin for wound healing.
Oral phenytoin is used widely for the treatment of convulsive disorders and about half the patients treated develop gingival overgrowth as a side effect. The apparent stimulatory effect has prompted its assessment in wound healing. Studies have shown topical phenytoin to promote healing of decubitus ulcers, venous stasis ulcers, diabetic ulcers, traumatic wounds, burns, and leprosy trophic ulcers. The mechanism of action has been postulated to be multifactorial. The present literature indicates that topical phenytoin deserves further investigation as a wound-healing agent in controlled dose-finding clinical trials.
Bhatia
Ashima
A
Department of Pharmacology, Maulana Azad Medical College, New Delhi. docbha@yahoo.com
Prakash
Surya
S
D000038:Abscess / Q000188:drug therapy; D000287:Administration, Topical; D002056:Burns / Q000188:drug therapy; D017364:Collagenases / Q000096:biosynthesis; D003238:Connective Tissue / Q000187:drug effects; D017719:Diabetic Foot / Q000188:drug therapy; D004341:Drug Evaluation; D004790:Enzyme Induction / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006097:Granulation Tissue / Q000187:drug effects; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011208:Powders; D012883:Skin Ulcer / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy
D011208:Powders; D010672:Phenytoin; D017364:Collagenases