Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection.
The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24 h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.
Ribeiro
Fabio
F
Laboratório de Esquistossomose, Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil.
Mello
Rômulo Teixeira de
RT
Tavares
Carlos Alberto Pereira
CA
Kusel
John Robert
JR
Coelho
Paulo Marcos Zech
PM
D000818:Animals; D000871:Anthelmintics / Q000276:immunology / Q000494:pharmacology*; D000909:Antibodies, Helminth / Q000187:drug effects / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000187:drug effects / Q000276:immunology; D051379:Mice; D011223:Praziquantel / Q000276:immunology / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
D000871:Anthelmintics; D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D011223:Praziquantel