title: Adiponectin gene polymorphism (G276T) is not associated with incipient diabetic nephropathy in Japanese type 2 diabetic patients.
abstract: A single-nucleotide polymorphism (SNP) G276T in the adiponectin gene has been associated with lower plasma adiponectin levels and insulin resistance, which are related to the prevalence of type 2 diabetes or diabetic complications of macroangiopathy. We performed a case-control study to examine whether the SNP276 of the adiponectin gene was also related to early diabetic nephropathy. SNP276 was examined with genomic DNA obtained from 108 type 2 diabetic patients with microalbuminuria (urinary albumin creatinine ratio [ACR] between 30 mg/g x Cr and 300 mg/g x Cr; case subjects), and 208 patients with normoalbuminuria (ACR < 30 mg/g x Cr; control subjects). The genotype distribution and G allele frequency of SNP276 in the case subjects (0.71) did not significantly differ from the control subjects (0.69). There were no differences among the genotypes of the adiponectin gene regarding age, duration of diabetes, body mass index (BMI), hemoglobin A(1c) (HbA(1c)), serum lipids, serum creatinine, and plasma adiponectin levels. These data suggest that SNP276 of the adiponectin gene is not an independent risk factor for incipient diabetic nephropathy in Japanese type 2 diabetic patients.
authors.affiliation: Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Toshihide
authors.initials: T
authors.lastname: Yoshida
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Umekawa
authors.forename: Akinori
authors.initials: A
authors.lastname: Kogure
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Takakura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Toda
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D052242:Adiponectin; D000419:Albuminuria / Q000378:metabolism; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005838:Genotype; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D052242:Adiponectin; D004247:DNA; D017931:DNA Primers; D006442:Glycated Hemoglobin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins