title: Factors influencing the compressive strength of an injectable calcium sulfate-hydroxyapatite cement.
abstract: A biphasic injectable bone substitute, suitable for filling bone defects, that sets in the body, based on calcium sulfate and hydroxyapatite (HA), is presented. For applications in bone defects the compressive strength is important to assure support of the defect site during loading when the patient is weight bearing. To control the strength, the influence of four different factors; the liquid-to-powder (L/P) ratio, the HA particle morphology, the HA content and the amount of accelerator, were investigated. alpha-Calcium sulfate hemihydrate (CSH) and four different HA powders (three sintered and one spray-dried) were used. All differed in size and morphology. CSH and each HA powder were mixed together with distilled water to form the bone substitute. An accelerator, in form of calcium sulfate dihydrate, was added to the powder phase to obtain an adequate setting time. Cylindrical specimens were compression tested. A lower L/P-ratio gave stronger cement, but was more difficult to inject. The shape and the morphology of the HA particles influenced the strength, and reducing the amount of HA increased the strength. The amount of accelerator (calcium sulfate dihydrate) had no influence.
authors.affiliation: Biomaterials and Biomechanics Lab, Department of Orthopaedics, BMC-C12, S-221 84 Lund, Sweden. malin.nilsson@ort.lu.se
authors.forename: M
authors.initials: M
authors.lastname: Nilsson
authors.forename: L
authors.initials: L
authors.lastname: Wielanek
authors.forename: J-S
authors.initials: JS
authors.lastname: Wang
authors.forename: K E
authors.initials: KE
authors.lastname: Tanner
authors.forename: L
authors.initials: L
authors.lastname: Lidgren