title: [Early diagnosis of prostate cancer using free/total prostate-specific antigen ratio with population-based screening data].
abstract: OBJECTIVE
  To evaluate the use of free/total prostate-specific antigen ratio (fPSA/tPSA ratio) in improving the early diagnosis of prostate cancer.
  
  
  METHODS
  fPSA/tPSA ratio in the serum was analyzed prospectively in 187 men with tPSA ranging between 4.0 and 20.0 microg/L. All of them underwent ultrasound-guided sextant prostatic biopsies. Sensitivity, specificity, positive and negative predictive values were calculated by SPSS 10.0 software.
  
  
  RESULTS
  Prostate cancer detection rates were 18.1% and 22.5% when tPSA was within the ranges of 4.0-10.0 g/L and 10.0-20.0 g/L respectively. fPSA/tPSA ratio was more significant than tPSA in all the men. When the cut-off value of fPSA/tPSA ratio was set at 0.25, 90.5% and 87.5% of cancers could be detected; and 26.7% and 11.3% of biopsies could be avoided within the tPSA ranges of 4.0-10.0 g/L and 10.0-20.0 g/L, respectively.
  
  
  CONCLUSIONS
  The use of fPSA/tPSA ratio can improve prostate cancer detection and reduce unnecessary biopsies when tPSA is within the range of 4.0-10.0 microg/L and 10.0-20.0 microg/L.
authors.affiliation: Research Center of Prostate Disease Prevention and Treatment, Jilin University, Changchun, Jilin 130021, China. zhanglingmail@sohu.com
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Guoyi
authors.initials: G
authors.lastname: Ji
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Li
authors.forename: Weihua
authors.initials: W
authors.lastname: Wang
authors.forename: Hongwen
authors.initials: H
authors.lastname: Gao
authors.forename: Yuzhuo
authors.initials: Y
authors.lastname: Pan
authors.forename: Hongjun
authors.initials: H
authors.lastname: Wang
authors.forename: Kuwahara
authors.initials: K
authors.lastname: Masaaki
authors.forename: Xuejian
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D042241:Early Diagnosis; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D017430:Prostate-Specific Antigen