title: Angiogenesis as an immunopharmacologic target in inflammation and cancer.
abstract: Many pathological processes including wound healing, chronic inflammation and cancer require angiogenesis, i.e., the formation of new vasculature in the lesions. Accumulating evidence indicates that angiogenesis is crucial for both chronic inflammation and the growth of malignant tumors with the participation of diverse cytokines, chemokines and growth factors. It is nevertheless believed that differences exist in angiogenesis between cancer and chronic inflammatory diseases. The aim of this review is to outline the characteristics of angiogenesis in chronic inflammation and cancer. A better understanding of the angiogenic processes may facilitate the design of more effective therapies for chronic inflammation and cancer.
authors.affiliation: Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR of China. bianxiuwu@263.net
authors.forename: Xiu Wu
authors.initials: XW
authors.lastname: Bian
authors.forename: Jian Hong
authors.initials: JH
authors.lastname: Chen
authors.forename: Xue Feng
authors.initials: XF
authors.lastname: Jiang
authors.forename: Jia Si
authors.initials: JS
authors.lastname: Bai
authors.forename: Qing Liang
authors.initials: QL
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D042783:Endothelial Cells / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000628:therapy*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000276:immunology* / Q000628:therapy*
chemical_list: D020533:Angiogenesis Inhibitors