title: CCK-8S systemic administration blocks the 7-nitroindazole-induced effects on the EEG of striatum and globus pallidus: a FFT analysis in the rat.
abstract: BACKGROUND
  Nitric oxide (NO) and cholecystokinin (CCK) are involved in the modulation of several neurotransmitter systems in the basal ganglia, and a functional interaction between their modulatory effects could be hypothesised.
  
  
  METHODS
  We studied the effects exerted by the administration of 7-nitroindazole (7-NI) (50 mg kg(-1) i.p.), a selective inhibitor of neuronal NO synthase, on the depth EEG activity of the striatum and of the globus pallidus in both not pre-treated and sulphated CCK octapeptide (CCK-SS)-treated (100 nM kg(-1) i.p.) rats. Striatal and pallidal depth EEG power spectra were examined by means of a Fast Fourier Transform analysis.
  
  
  RESULTS
  Striatal depth recordings showed a marked increase of % power of slow standard rhythms after 7-NI systemic treatment. In contrast, pallidal recordings revealed an increase of % power of rapid standard rhythms after i.p. injection of 7-NI. The same modifications were not evidenced in CCK-8S pre-treated rats after 7-NI administration.
  
  
  CONCLUSIONS
  The results show an influence exerted by peripheral CCK on the nitrergic modulation of the bioelectric activities of the striatum and of the globus pallidus. This effect could be of particular interest in the light of NO and CCK involvement in the neuroprotective mechanisms.
authors.affiliation: Dipartimento di Medicina sperimentale, Sezione di Fisiologia umana "G. Pagano", Università degli Studi di Palermo, Corso Tuköry, 129, 90134 Palermo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ferraro
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Sardo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Giovanni
authors.forename: Rosaria
authors.initials: R
authors.lastname: Fileccia
authors.forename: Vittorio
authors.initials: V
authors.lastname: La Grutta
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography / Q000187:drug effects*; D005917:Globus Pallidus / Q000187:drug effects / Q000502:physiology; D008297:Male; D009593:Nitroimidazoles / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C090019:8-sulfocholecystokinin octapeptide; D009593:Nitroimidazoles; D018697:Nootropic Agents; D012844:Sincalide