title: Differential gene expression after implantation of biomaterials into rat gastrointestine.
abstract: Two biodegradable materials, polyglycolide-copoly(L)-lactide/poly-dioxanone composite and poly(3-hydroxybutyrate), have been employed for surgery in the gastrointestine of laboratory rats. The tissue response was analyzed at distinct time intervals up to 2 months by differential mRNA display. Two specific PCR fragments were transiently present 7 and 14 days after contact with poly(3-hydroxybutyrate). Both fragments represent distinct rat lipases which might play a role in poly(3-hydroxybutyrate) degradation.
authors.affiliation: Chirurgische Universitätsklinik, Universität Rostock, Schillingallee 35, D-18057 Rostock, Germany. marian.loebler@medizin.uni-rostock.de
authors.forename: M
authors.initials: M
authors.lastname: Löbler
authors.forename: M
authors.initials: M
authors.lastname: Sass
authors.forename: P
authors.initials: P
authors.lastname: Michel
authors.forename: U T
authors.initials: UT
authors.lastname: Hopt
authors.forename: C
authors.initials: C
authors.lastname: Kunze
authors.forename: K P
authors.initials: KP
authors.lastname: Schmitz