title: Simultaneous appearance of trisomy 8 and trisomy 12 in different cell populations in a patient with untreated B-cell chronic lymphocytic leukemia and myelodysplasia.
abstract: The co-existence of spontaneously arising myeloid and lymphoid malignancies in the same patient is rare, and is thought to be mainly due to chance. We describe a patient presenting simultaneously with chronic lymphocytic leukemia (CLL) and myelodysplasia (MDS). Histological, flow cytometric, chromosomal and fluorescent in situ hybridization (FISH) studies show that both cell populations possess different sets of markers consistent with the myeloid and lymphoid differentiation pathways. The question of whether these arose from a single or two separate progenitor cells is explored.
authors.affiliation: Center for Human and Molecular Genetics, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA. avivha@umdnj.edu
authors.forename: Hana
authors.initials: H
authors.lastname: Aviv
authors.forename: Denga
authors.initials: D
authors.lastname: Tang
authors.forename: Kasturi
authors.initials: K
authors.lastname: Das
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Harrison
authors.forename: Meera
authors.initials: M
authors.lastname: Hameed
authors.forename: Mala
authors.initials: M
authors.lastname: Varma
mesh_terms: D002454:Cell Differentiation; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D022423:Myeloid Cells / Q000473:pathology*; D015398:Signal Transduction; D014314:Trisomy