[Comparison of animal models of hyperlipidemia].
OBJECTIVE
To select the proper experimental animal model for research on prevention and treatment of hyperlipidemia.


METHODS
Hyperlipidemia models of mouse, rat, golden hamster, guinea pig, rabbit, pigeon and quail often used in the last ten years were compared.


RESULTS
Golden hamster and guinea pig models are similar to human beings in lipid metabolism and have unique superiority in experimental study, while the models of rat, mouse, pigeon and quail have significant difference as compared with human beings. Rabbit is one of the best animal models in studying new drugs for regulating lipid and treating arteriosclerosis.


CONCLUSIONS
Factors such as the required time, indexes, the duration of making models, and the cost and feeding of animals should be considered in selecting animal models according with the experimental requirements.
Liu
Xue-Mei
XM
Department of Pharmacology for Chinese Materia Medica, Fujian College of Traditional Chinese Medicine, Fuzhou, Fujian Province 350003, China. meizir02@163.com
Wu
Fu-Huo
FH
D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006949:Hyperlipidemias / Q000188:drug therapy / Q000209:etiology*; D008647:Mesocricetus; D051379:Mice; D011817:Rabbits; D051381:Rats