Sulfoacetate generated by Rhodopseudomonas palustris from taurine.
Genes thought to encode (a) the regulator of taurine catabolism under carbon-limiting or nitrogen-limiting conditions and (b) taurine dehydrogenase were found in the genome of Rhodopseudomonas palustris. The organism utilized taurine quantitatively as a sole source of nitrogen (but not of carbon) for aerobic and photoheterotrophic growth. No sulfate was released, and the C-sulfonate bond was recovered stoichiometrically as sulfoacetate, which was identified by mass spectrometry. An inducible sulfoacetaldehyde dehydrogenase was detected. R. palustris thus contains a pathway to generate a natural product that was previously believed to be formed solely from sulfoquinovose.
Denger
Karin
K
Fachbereich Biologie der Universität Konstanz, 78457 Konstanz, Germany.
Weinitschke
Sonja
S
Hollemeyer
Klaus
K
Cook
Alasdair M
AM
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000378:metabolism; D000085:Acetates / Q000032:analysis / Q000378:metabolism*; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D050728:Betaine-Aldehyde Dehydrogenase; D012241:Rhodopseudomonas / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism; D013654:Taurine / Q000378:metabolism*
D000085:Acetates; D013431:Sulfates; D013654:Taurine; C015517:sulfoacetaldehyde; D000445:Aldehyde Oxidoreductases; D050728:Betaine-Aldehyde Dehydrogenase; D000079:Acetaldehyde