title: A one-year comparison of prophylactic donor tricuspid annuloplasty in heart transplantation.
abstract: BACKGROUND
  The bicaval technique for orthotopic heart transplantation decreases the incidence of tricuspid valve regurgitation when compared with the standard biatrial technique. This study was designed to study the effects of prophylactic tricuspid valve annuloplasty during bicaval orthotopic heart transplantation on survival, renal function, and amount of tricuspid valve regurgitation.
  
  
  METHODS
  Between April 1997 and March 1998, 60 patients (age 18 to 70 years, 22 women) randomly received either bicaval orthotopic heart transplantation (n = 30) or bicaval orthotopic heart transplantation with DeVega tricuspid valve annuloplasty (n = 30). Tricuspid valve annuloplasty was performed on the donor heart before implantation using pledgeted 2-0 polypropylene suture and sized to an annulus of 29 mm. Echocardiographic variables, laboratory values, and hemodynamics were obtained prospectively and reviewed by an independent data analyst.
  
  
  RESULTS
  Intraoperatively, the group undergoing tricuspid valve annuloplasty had a shorter reperfusion time (46 +/- 29 minutes versus 65 +/- 48 minutes; p < 0.05) and higher mean pulmonary artery to central venous pressure difference (11.8 +/- 3.7 mm Hg versus 15.3 +/- 4.1 mm Hg; p = 0.001). Additional differences between the two groups included early mortality from donor dysfunction (4 of 30 patients versus 0 of 30 patients; p < 0.05), amount of tricuspid valve regurgitation at 1 year (1.3 +/- 1.0 versus 0.2 +/- 0.3; p < 0.05), and percentage of patients with 2+ or greater tricuspid valve regurgitation (34% versus 0%; p < 0.05).
  
  
  CONCLUSIONS
  Tricuspid valve annuloplasty of the donor heart before bicaval orthotopic heart transplantation improves immediate donor heart function as demonstrated by better right ventricular performance, lower perioperative mortality, and shorter reperfusion times. At 1 year, there is less tricuspid valve regurgitation but no difference in renal function. Considering the ease and safety of tricuspid valve annuloplasty and its advantages, it should be performed as a routine adjunct with bicaval orthotopic heart transplantation.
authors.affiliation: Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA. jeevan@uchicago.edu
authors.forename: Valluvan
authors.initials: V
authors.lastname: Jeevanandam
authors.forename: Hyde
authors.initials: H
authors.lastname: Russell
authors.forename: Paul
authors.initials: P
authors.lastname: Mather
authors.forename: Satoshi
authors.initials: S
authors.lastname: Furukawa
authors.forename: Allen
authors.initials: A
authors.lastname: Anderson
authors.forename: Frank
authors.initials: F
authors.lastname: Grzywacz
authors.forename: Jaishankar
authors.initials: J
authors.lastname: Raman
mesh_terms: D000328:Adult; D000368:Aged; D002320:Cardiovascular Physiological Phenomena; D004452:Echocardiography; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality / Q000502:physiology; D006801:Humans; D015994:Incidence; D007432:Intraoperative Period; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D014019:Tissue Donors; D014261:Tricuspid Valve / Q000601:surgery*; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*