Steering growth cones with a CaMKII/calcineurin switch.
Calcium can regulate and induce both attractive and repulsive turnings by growth cones. In this issue of Neuron, Wen et al. report that differential activations of CaMKII and calcineurin (CaN) act as the read out for distinct patterns of intracellular calcium signals and a switch between attraction and repulsion.
Wang
Fan
F
Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC 27710, USA.
D000818:Animals; D019703:Calcineurin / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology*; D020439:Growth Cones / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014981:Xenopus
D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019703:Calcineurin; D002118:Calcium