title: Staphylococcus aureus adhesion to different treated titanium surfaces.
abstract: Staphylococcus aureus is a major pathogen, associated with medical-device related infections. Converting biomaterial surfaces into non-interactive surfaces requires a specific surface/interface design. One approach is to polish the surface, and a second is to coat the surface with an antimicrobial or protein resistant coating. This study showed that polishing a titanium surface or coating titanium with various treatments that decreased the surface's coefficient of friction, had no significant effect on minimising S. aureus adhesion to these surfaces under static conditions in comparison to standard medical grade titanium. The cell promoting coating, TAST, was found to increase the S. aureus density on its surface as expected. The only coating that significantly decreased the density of adhering S. aureus was the titanium surface coated with sodium hyaluronate. Thus such a coating could have potential use as a coating for ostoesynthesis, orthopaedic or dental implants.
authors.affiliation: AO Research Institute, Clavadelerstrasse, CH7270 Davos Platz, Switzerland.
authors.forename: L G
authors.initials: LG
authors.lastname: Harris
authors.forename: R G
authors.initials: RG
authors.lastname: Richards
mesh_terms: D000900:Anti-Bacterial Agents; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D017276:Friction; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000494:pharmacology*; D008422:Materials Testing; D013210:Staphylococcus / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000145:classification
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D006820:Hyaluronic Acid; D014025:Titanium