title: Treatment of acute lower limb ischemia following the use of the Duett sealing device: report of three cases and review of the literature.
abstract: Three cases of local thrombolysis in the treatment of acute lower limb ischemia complicating the utilization of the Duett sealing device are presented. Routine usage of several vascular closure devices after cardiac catheterization and percutaneous coronary intervention (PCI) has been adopted in our institution during the last 3 years (September 1999 to April 2003). The Duett closure device has been used in 420 patients (post-coronary angiography, 359; post-PCI, 61). Three patients (0.7%) demonstrated acute leg ischemia used by inadvertent intravascular administration of the sealing material related to this device. All three were treated successfully by catheter-directed local thromolysis (tissue plasminogen activator 5 mg bolus followed initially by 1 mg/hr and consequently by 0.5-1.0 mg/hr depending upon the development of significant hematoma and lasting for 24 hr). In conclusion, interventional treatment using local thrombolysis should be the first-line treatment in acute lower limb ischemia complicating the utilization of the Duett sealing device.
authors.affiliation: Department of Cardiology, Medical School of Ioannina, GR 451 10 Ioannina, Greece.
authors.forename: C S
authors.initials: CS
authors.lastname: Katsouras
authors.forename: L K
authors.initials: LK
authors.lastname: Michalis
authors.forename: I
authors.initials: I
authors.lastname: Leontaridis
authors.forename: T
authors.initials: T
authors.lastname: Kolettis
authors.forename: K K
authors.initials: KK
authors.lastname: Naka
authors.forename: J A
authors.initials: JA
authors.lastname: Goudevenos
authors.forename: M R
authors.initials: MR
authors.lastname: Rees
authors.forename: D A
authors.initials: DA
authors.lastname: Sideris
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods; D000925:Anticoagulants / Q000627:therapeutic use; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D005263:Femoral Artery; D005500:Follow-Up Studies; D006489:Hemostatic Techniques / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery; D012189:Retrospective Studies; D018570:Risk Assessment; D015912:Thrombolytic Therapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants