title: Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literature.
abstract: BACKGROUND
  Metastatic cancer to the vulva is a rare diagnosis and is estimated to account for 5-8% of all vulvar cancers.
  
  
  METHODS
  A 57-year-old postmenopausal woman was referred for the evaluation of a new vulvar mass. CT scan of the pelvis demonstrated a 4 x 6 cm lobular mass of the left labia. An outpatient excisional biopsy revealed a poorly differentiated large cell carcinoma with prominent necrosis and focal perineural invasion consistent with a bronchogenic carcinoma. A subsequent PET scan of the chest revealed a large primary lung carcinoma confirmed by CT-guided biopsy that was identical to the vulvar tumor.
  
  
  CONCLUSIONS
  This case represents the only literature described primary lung carcinoma presenting as a vulvar metastasis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233, USA. rocconi@uab.edu
authors.forename: Rodney P
authors.initials: RP
authors.lastname: Rocconi
authors.forename: Charles A
authors.initials: CA
authors.lastname: Leath
authors.forename: William M
authors.initials: WM
authors.lastname: Johnson
authors.forename: Mack N
authors.initials: MN
authors.lastname: Barnes
authors.forename: Michael G
authors.initials: MG
authors.lastname: Conner
mesh_terms: D018287:Carcinoma, Large Cell / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000473:pathology / Q000556:secondary*