title: Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population.
abstract: We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan. hiroyuki@jichi.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Matsuoka
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan.
authors.forename: Jichun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirai
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan.
authors.forename: Meiji
authors.initials: M
authors.lastname: Arai
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi, 329-0498, Japan.
authors.forename: Shigeto
authors.initials: S
authors.lastname: Yoshida
authors.affiliation: Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Department of Advanced Medical Science, Nagoya University Graduate School of Medicine, Showa, Nagoya, Japan.
authors.forename: Amadu
authors.initials: A
authors.lastname: Jalloh
authors.affiliation: Parasitology Division, Department of Medical Research, Upper Myanmar, Myanmar.
authors.forename: Khin
authors.initials: K
authors.lastname: Lin
authors.affiliation: Faculty of Medicine, Institute of Scientific Research, Oita University, Oita, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kawamoto
mesh_terms: D005006:Ethnicity / Q000235:genetics; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D008288:Malaria / Q000175:diagnosis / Q000235:genetics; D009154:Mutation; D002052:Myanmar
chemical_list: D005954:Glucosephosphate Dehydrogenase