Mechanics and hemodynamics of esophageal varices during peristaltic contraction.
Our hypothesis states that variceal pressure and wall tension increase dramatically during esophageal peristaltic contractions. This increase in pressure and wall tension is a natural consequence of the anatomy and physiology of the esophagus and of the esophageal venous plexus. The purpose of this study was to evaluate variceal hemodynamics during peristaltic contraction. A simultaneous ultrasound probe and manometry catheter was placed in the distal esophagus in nine patients with esophageal varices. Simultaneous esophageal luminal pressure and ultrasound images of varices were recorded during peristaltic contraction. Maximum variceal cross-sectional area and esophageal luminal pressures at which the varix flattened, closed, and opened were measured. The esophageal lumen pressure equals the intravariceal pressure at variceal flattening due to force balance laws. The mean flattening pressures (40.11 +/- 16.77 mmHg) were significantly higher than the mean opening pressures (11.56 +/- 25.56 mmHg) (P < or = 0.0001). Flattening pressures >80 mmHg were generated during peristaltic contractions in 15.5% of the swallows. Variceal cross-sectional area increased a mean of 41% above baseline (range 7-89%, P < 0.0001) during swallowing. The peak closing pressures in patients that experience future variceal bleeding were significantly higher than the peak closing pressures in patients that did not experience variceal bleeding (P < 0.04). Patients with a mean peak closing pressure >61 mmHg were more likely to bleed. In this study, accuracy of predicting future variceal bleeding, based on these criteria, was 100%. Variceal models were developed, and it was demonstrated that during peristaltic contraction there was a significant increase in intravariceal pressure over baseline intravariceal pressure and that the peak intravariceal pressures were directly proportional to the resistance at the gastroesophageal junction. In conclusion, esophageal peristalsis in combination with high resistance to blood flow through the gastroesophageal junction leads to distension of the esophageal varices and an increase in intravariceal pressure and wall tension.
Miller
Larry S
LS
Dept. of Gastroenterology, Temple Univ. Hospital, 3401 North Broad St., Philadelphia, PA 19140, USA.
Kim
Joseph K
JK
Dai
Qing
Q
Mekapati
Jyothi
J
Izanec
James
J
Chung
Chan
C
Liu
Ji-Bin
JB
Sanderson
Andrew
A
Bohning
Matt
M
Desipio
Josh
J
Gandegok
Jasneet
J
Harberson
Justin J
JJ
Schneck
Carson
C
Nicosia
Mark A
MA
Thangada
Vinod
V
Thomas
Beje
B
Copeland
Brian
B
Miller
Elan
E
Miller
Aaron
A
Ahmed
Naji
N
Brasseur
James G
JG
D000328:Adult; D003679:Deglutition; D004932:Esophageal and Gastric Varices / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004947:Esophagus / Q000098:blood supply* / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008953:Models, Anatomic; D009119:Muscle Contraction / Q000502:physiology*; D010528:Peristalsis / Q000502:physiology*; D011312:Pressure; D014463:Ultrasonography