Screening for Parkinson's disease with response time batteries: a pilot study.
BACKGROUND
Although significant response time deficits (both reaction time and movement time) have been identified in numerous studies of patients with Parkinson's disease (PD), few attempts have been made to evaluate the use of these measures in screening for PD.


METHODS
Receiver operator characteristic curves were used to identify cutoff scores for a unit-weighted composite of two choice response tasks in a sample of 40 patients and 40 healthy participants. These scores were then cross-validated in an independent sample of 20 patients and 20 healthy participants.


RESULTS
The unit-weighted movement time composite demonstrated high sensitivity (90%) and specificity (90%) in the identification of PD. Movement time was also significantly correlated (r = 0.59, p < 0.025) with the motor score of the Unified Parkinson's Disease Rating Scale (UPDRS).


CONCLUSIONS
Measures of chronometric speed, assessed without the use of biomechanically complex movements, have a potential role in screening for PD. Furthermore, the significant correlation between movement time and UPDRS motor score suggests that movement time may be useful in the quantification of PD severity.
Johnson
Andrew M
AM
Faculty of Health Sciences, University of Western Ontario, London, ON, Canada. ajohnson@uwo.ca
Vernon
Philip A
PA
Almeida
Quincy J
QJ
Grantier
Linda L
LL
Singarayer
Rene
R
Jog
Mandar S
MS
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009460:Neurologic Examination / Q000379:methods*; D009864:Ontario; D010300:Parkinson Disease / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D010865:Pilot Projects; D011930:Reaction Time / Q000502:physiology*; D012720:Severity of Illness Index