title: Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzothiazolon-3-yl)propanamide derivatives.
abstract: Ten new (5-chloro-2(3H)-benzothiazolon-3-yl)propanamide derivatives have been synthesized. The compounds were tested for antinociceptive activity by tail clip, tail flick, hot plate and writhing test by using aspirin and dipyrone as standards. Among these compounds, 1-[3-(5-chloro-2(3H)-benzothiazolon-3-yl)-propanoyl]-4-(4-chlorophenyl)piperazine (11e) has been found to be significantly more active than the other compounds synthesized as well as the standards in all tests.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
authors.forename: Tijen
authors.initials: T
authors.lastname: Onkol
authors.forename: Engin
authors.initials: E
authors.lastname: Yildirim
authors.forename: Kevser
authors.initials: K
authors.lastname: Erol
authors.forename: Shigero
authors.initials: S
authors.lastname: Ito
authors.forename: M Fethi
authors.initials: MF
authors.lastname: Sahin
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D018712:Analgesics, Non-Narcotic; D013844:Thiazoles