title: Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation.
abstract: We combine diffuse optical and correlation spectroscopies to simultaneously measure the oxyhemoglobin and deoxyhemoglobin concentration and blood flow in an adult human brain during sensorimotor stimulation. The observations permit calculation of the relative cerebral metabolic rate of oxygen in the human brain, for the first time to our knowledge, by use of all-optical methods. The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored.
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. durduran@stwing.upenn.edu
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Mark G
authors.initials: MG
authors.lastname: Burnett
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
authors.forename: Joel H
authors.initials: JH
authors.lastname: Greenberg
authors.forename: Jiongjiong
authors.initials: J
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000378:metabolism / Q000502:physiology*; D055095:Optics and Photonics; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D013003:Somatosensory Cortex / Q000378:metabolism / Q000502:physiology*
chemical_list: D010100:Oxygen