Neuropeptide y in euthymic lithium-treated women with bipolar disorder.
Plasma neuropeptide Y-like immunoreactivity (NPY-LI) and platelet cyclic AMP (cAMP) activity were determined in 13 women with bipolar disorder stabilized on lithium (Li) and 12 matched healthy controls. No differences in plasma NPY-LI were found between the two groups. In euthymic Li-treated bipolar patients, there was an inverse correlation between plasma NPY-LI levels and intracellular cAMP in prostaglandin E1-stimulated platelets. A positive correlation was found between plasma NPY-LI levels and age in both the patient and the control group. Our findings support earlier findings that NPY is capable of inhibiting adenylyl cyclase and that aging is a physiological factor in regulating NPY-LI levels.
El Khoury
Aram
A
Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, Stockholm, Sweden. aram.el.khoury@cns.ki.se
Mathé
Aleksander A
AA
D000262:Adenylyl Cyclases / Q000494:pharmacology; D000328:Adult; D000375:Aging / Q000502:physiology; D000527:Alprostadil / Q000494:pharmacology; D018692:Antimanic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology*; D001792:Blood Platelets / Q000502:physiology; D016022:Case-Control Studies; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood*; D013950:Thymus Gland / Q000502:physiology
D018692:Antimanic Agents; D009478:Neuropeptide Y; D016651:Lithium Carbonate; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000527:Alprostadil