Design, synthesis, and biochemical evaluation of novel alpha V beta 3 integrin ligands.
Studies on integrin alphaVbeta3 have implicated this receptor in a number of pathologies. In this article we describe some of our initial efforts to design small molecules alphaVbeta3 ligands incorporating an indole core template and an oxyguanidine as basic ending. Synthesis, biochemical activity and pharmacological properties are analyzed.
Marugan
Juan Jose
JJ
3-Dimensional Pharmaceuticals, Inc, Eagleview Corporate Center, 665 Stockton Drive, Suite 104, Exton, PA 19341, USA. jmaruga1@prdus.jnj.com
Haslow
Kristin D
KD
Crysler
Carl
C
D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D039302:Integrin alphaVbeta3 / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands
D039302:Integrin alphaVbeta3; D008024:Ligands