title: The influence of polymer blend composition on the degradation of polymer/hydroxyapatite biomaterials.
abstract: The in vitro degradation of biodegradable polymer/ceramic composites was assessed in two different environments under both static and pseudodynamic conditions. The blends, consisting of polycaprolactone, poly(lactic-co-glycolic acid), and hydroxyapatite, have potential use in bone tissue engineering applications, thus it is essential to establish a standardized method of characterizing the degradation of new biomaterials. In this study, the variation in polymer blend ratio was examined to observe a change in degradation rate. The porous blends were degraded in water and serum-containing media. A previous study examined in vitro degradation in serum-free buffer. Molecular weight loss, gravimetric weight loss, pH changes and morphological changes were evaluated. The changes in porosity were observed with scanning electron microscopy and quantitatively assessed using image analysis. There was a significant difference in molecular weight loss and gravimetric weight loss between the blends after 10 weeks in vitro. Blends containing the greatest amount of poly(lactic-co-glycolic acid) degraded most rapidly.
authors.affiliation: The Institute for Complex Engineered Systems, The Biomedical and Health Engineering Program, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Dunn
authors.forename: P G
authors.initials: PG
authors.lastname: Campbell
authors.forename: K G
authors.initials: KG
authors.lastname: Marra