Integrin signalling and the cellular response to ionizing radiation.
Cell survival and cycling in mammalian cells are both greatly affected by ionizing radiation and are both strictly controlled by integrated integrin-mediated adhesion to extracellular matrix (ECM) proteins and by binding of growth factors to their cognate receptors. Recent emerging findings show a diverse panel of integrin-dependent signals that are channelled into the regulation and modification of the cellular response to ionizing radiation. Cell adhesion-mediated radioresistance and alteration of DNA damage-induced cell cycle arrest in cells attached to the ECM can be linked to focal adhesion protein signalling. This review summarizes the latest radiobiological and radiooncological findings about integrins and their signal transduction pathways.
Cordes
Nils
N
Bundeswehr Institute of Radiobiology, Neuherbergstrasse 11, 80937 Munich, Germany. cordes@radiation-biology.de
Meineke
Viktor
V
D000818:Animals; D002448:Cell Adhesion / Q000528:radiation effects*; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000528:radiation effects*; D002453:Cell Cycle / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D016326:Extracellular Matrix Proteins / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D011832:Radiation Injuries / Q000378:metabolism*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D015398:Signal Transduction
D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D016023:Integrins