Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites.
Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened 252 primary MALT lymphomas for translocations t(11;18)(q21;q21), t(14;18)(q32;q21), and t(1;14)(p22;q32), and trisomies 3 and 18. The above-listed translocations occurred mutually exclusively and were detected overall in 13.5, 10.8, and 1.6% of the cases; trisomy 3 and/or 18 occurred in 42.1%. The frequency at which the translocations occurred varied markedly with the primary site of disease. The t(11;18)(q21;q21) was mainly detected in pulmonary and gastric tumors, whereas the t(14;18)(q32;q21) was most commonly found in lesions of the ocular adnexa/orbit, skin, and salivary glands. Trisomies 3 and 18 each occurred most frequently in intestinal and salivary gland MALT lymphomas. Our results demonstrate that the three translocations and trisomies 3 and 18 occur at markedly variable frequencies in MALT lymphoma of different sites.
Streubel
B
B
Institute of Pathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Simonitsch-Klupp
I
I
Müllauer
L
L
Lamprecht
A
A
Huber
D
D
Siebert
R
R
Stolte
M
M
Trautinger
F
F
Lukas
J
J
Püspök
A
A
Formanek
M
M
Assanasen
T
T
Müller-Hermelink
H-K
HK
Cerroni
L
L
Raderer
M
M
Chott
A
A
D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000145:classification / Q000235:genetics* / Q000473:pathology; D009928:Organ Specificity; D014178:Translocation, Genetic; D014314:Trisomy / Q000235:genetics*