[Effect of Baisuifang Granule on cognitive malfunction after cerebral infarction].
OBJECTIVE
To explore the mechanism of Baisuifang Granule in treating cognitive malfunction after cerebral infarction.


METHODS
One hundred and sixty patients with cerebral infarction were divided randomly into two groups. Eighty patients were treated with Baisuifang Granule and 80 with nimodipine for two months. Clinical observation and laboratory examinations were performed for Mini-Mental State Examination (MMSE), clinical symptoms, Chinese Stroke Scale (CSS), hemorrheological indexes and fibrinogen before and after the treatment.


RESULTS
Baisuifang Granule could improve MMSE, reduce the scores of clinical symptoms and CSS, and meliorate the blood rheology. The total effective rate for clinical symptoms in the Baisuifang treated group accounted to 76.25%, with statistical difference comparing to 58.75% of nimodipine treated group (P<0.05). There was significant difference in symptom integral, CSS and whole blood viscosity at the high shear rate, respectively (P<0.01).


CONCLUSIONS
Baisuifang Granule is an effective Chinese medicine for treating cognitive malfunction after cerebral infarction.
Zheng
Lan
L
Department of Traditional Chinese Medicine, RuiJin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Shen
Xiao-Heng
XH
Wang
Ying
Y
Li
Wei
W
Zhai
Yu
Y
Tang
Xue-Mei
XM
Yuan
Chan-Xing
CX
Chen
Yun
Y
Li
Jun
J
Xia
Xiang
X
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001809:Blood Viscosity / Q000187:drug effects; D002544:Cerebral Infarction / Q000150:complications*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000627:therapeutic use; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D009553:Nimodipine