title: Immunogenicity of an inactivated oil-emulsion canine distemper vaccine in African wild dogs.
abstract: The immunogenicity of an inactivated oil-emulsion vaccine against canine distemper virus was evaluated in nine captive African wild dogs (Lycaon pictus). Antibody levels were determined by neutralization test in Vero cells. No significant local or systemic adverse reactions were observed in the animals. Virus neutralizing antibody levels >1:20 were detected, especially in animals that were vaccinated twice. The use of oil adjuvants is suggested as a good way to enhance the immune response to inactivated canine distemper vaccine.
authors.affiliation: Department of Animal Health and Well-being, Faculty of Veterinary Medicine of Bari, Valenzano, Italy. f.cirone@veterinaria.uniba.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Cirone
authors.forename: Gabriella
authors.initials: G
authors.lastname: Elia
authors.forename: Marco
authors.initials: M
authors.lastname: Campolo
authors.forename: Klaus
authors.initials: K
authors.lastname: Friedrich
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Annamaria
authors.initials: A
authors.lastname: Pratelli
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D000835:Animals, Wild; D000914:Antibodies, Viral / Q000097:blood*; D046028:Canidae; D004216:Distemper / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology*; D004285:Dogs; D004655:Emulsions; D005260:Female; D008297:Male; D009500:Neutralization Tests / Q000662:veterinary; D016896:Treatment Outcome; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D004655:Emulsions; D015164:Vaccines, Inactivated; D014765:Viral Vaccines