Integrin-linked kinase: integrin's mysterious partner.
Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases. The functions of integrins are mediated through the recruitment of cytoplasmic plaque proteins. One of these is integrin-linked kinase, which connects integrins to the actin cytoskeleton and transduces signals through integrins to the extracellular matrix and from integrins to various subcellular compartments.
Grashoff
Carsten
C
Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Thievessen
Ingo
I
Lorenz
Katrin
K
Ussar
Siegfried
S
Fässler
Reinhard
R
D000185:Actinin / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001665:Binding Sites; D002448:Cell Adhesion / Q000502:physiology; D003593:Cytoplasm / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D060588:LIM Domain Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D008954:Models, Biological; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D000099200:Scaffold Protein ILK; D000096985:Calponins
D000185:Actinin; D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; D016023:Integrins; D060588:LIM Domain Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK; C490232:Lims1 protein, mouse; C486590:PARVA protein, human; D000096985:Calponins; C486591:PARVB protein, human