Effect of dietary n-3 and n-6 fatty acids on tobramycin induced nephrotoxicity.
Post fish oil(n-3 fatty acids) treatment (5mg/kg/day for 12 days) was effective in bringing the reversal of tobramycin (160mg/kg/day,ip for 12 days) induced nephrotoxicity in albino rats as was evident by normal urea, creatinine, cholesterol and inorganic phosphate levels in the serum of the treatment group compared with group receiving tobramycin only. The return of normal levels of alkaline and acid phosphatase in kidney homogenates of post fish oil treatment group also indicated the beneficial effect of dietary n-3 fatty acids(fish oil) more than n-6 fatty acids(olive oil).The results suggest that oral supplements of dietary n-3 fatty acids (fish oil) for nearly two weeks after tobramycin exposure is more beneficial than n-6 fatty acids (olive oil) as it results in reversal of nephrotoxicity induced by tobramycin.
Sheema
M Kaleem
MK
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202 002, India. sheemabiochem@yahoo.co.in
Bano
Bilqees
B
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014031:Tobramycin / Q000633:toxicity*
D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D014031:Tobramycin