Characterization of extended-spectrum-beta-lactamase (CTX-M-15)-producing strains of Salmonella enterica isolated in France and Senegal.
Three clinical isolates of Salmonella enterica recovered between 2000 and 2003 in France and Senegal were found to produce extended-spectrum beta-lactamase CTX-M-15. The two isolates from Senegal were recovered from stool of a hospitalized patient with gastroenteritis in 2000 and from an urine specimen of an out-patient with urinary tract infection in 2001. These S. enterica isolates belonged to serotype Kentucky and were clonally related as determined by pulsed-field gel electrophoresis and automated ribotyping. The third isolate of serotype Typhimurium was recovered from a patient hospitalized in France for an acute gastroenteritis acquired in Lebanon. The bla(CTX-M-15) gene was located on two different transferable plasmids, one of which also carried bla(TEM-1), bla(OXA-30), aminoglycoside-, tetracycline-, and sulfamethoxazole-trimethoprim resistance genes. ISEcp1 element was found to be located upstream of bla(CTX-M-15) in the same position as reported previously in CTX-M-15-producing Escherichia coli from India and Turkey. This is the first report of bla(CTX-M-15) in the genus Salmonella.
Weill
François-Xavier
FX
Centre National de Référence des Salmonella, Unité de Biodiversité des Bactéries Pathogènes Emergentes, Institut Pasteur, INSERM U 389; 28 rue du Docteur Roux, 75724 Paris cedex 15, France. fxweill@pasteur.fr
Perrier-Gros-Claude
Jean-David
JD
Demartin
Marie
M
Coignard
Sophie
S
Grimont
Patrick A D
PA
D004251:DNA Transposable Elements / Q000235:genetics; D005243:Feces / Q000382:microbiology; D005602:France; D006801:Humans; D010957:Plasmids / Q000235:genetics*; D021521:Ribotyping; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology; D019779:Salmonella enterica / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D012675:Senegal; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
D004251:DNA Transposable Elements; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases