Positron emission tomography in patients with fibromyalgia syndrome and healthy controls.
OBJECTIVE
Abnormal brain findings have previously been described in fibromyalgia syndrome (FMS) by single-photon-emission computed tomography. Our goal was to investigate change in regional cerebral glucose metabolism in people with FMS by positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG).


METHODS
Twelve patients with FMS and no comorbid psychiatric diagnosis and 7 healthy pain-free controls were studied with FDG-PET in a blinded manner. Those with a psychiatric diagnosis were excluded. Brain scans were obtained using a PET scanner. Semiquantitative analysis of regional 18F-FDG uptake was performed in both cortical and subcortical brain structures.


RESULTS
In the resting state, there were no significant differences in 18F-FDG uptake between patients and controls for all brain structures measured.


CONCLUSIONS
FDG-PET scan findings in FMS were not significantly different from healthy controls. Normal results in our study may be explained by discordance between regional cerebral blood flow and regional cerebral glucose metabolism.
Yunus
Muhammad B
MB
University of Illinois College of Medicine at Peoria, IL 61656, USA. Yunus@uic.edu
Young
Carter S
CS
Saeed
S Atezaz
SA
Mountz
James M
JM
Aldag
Jean C
JC
D000328:Adult; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D005260:Female; D005356:Fibromyalgia / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D014055:Tomography, Emission-Computed
D019788:Fluorodeoxyglucose F18; D005947:Glucose