title: The CLDN5 locus may be involved in the vulnerability to schizophrenia.
abstract: The present study was designed to detect three single nucleotide polymorphisms (SNPs) located on 22q11 that was thought as being of particularly importance for genetic research into schizophrenia. We recruited a total of 176 Chinese family trios of Han descent, consisting of mothers, fathers and affected offspring with schizophrenia for the genetic analysis. The transmission disequilibrium test (TDT) showed that of three SNPs, rs10314 in the 3'-untranslated region of the CLDN5 locus was associated with schizophrenia (chi(2) = 4.75, P = 0.029). The other two SNPs, rs1548359 present in the CDC45L locus centromeric of rs10314 and rs739371 in the 5'-flanking region of the CLDN5 locus, did not show such an association. The global chi-square (chi(2)) test showed that the 3-SNP haplotype system was not associated with schizophrenia although the 1-df test for individual haplotypes showed that the rs1548359(C)-rs10314(G)-rs739371(C) haplotype was excessively non-transmitted (chi(2) = 5.32, P = 0.02). Because the claudin proteins are a major component for barrier-forming tight junctions that could play a crucial role in response to changing natural, physiological and pathological conditions, the CLDN5 association with schizophrenia may be an important clue leading to look into a meeting point of genetic and environmental factors.
authors.affiliation: Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: L
authors.initials: L
authors.lastname: Xie
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: S-Z
authors.initials: SZ
authors.lastname: Liu
authors.forename: G-Z
authors.initials: GZ
authors.lastname: Ju
authors.forename: J-P
authors.initials: JP
authors.lastname: Shi
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Yu
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Xu
authors.forename: G P
authors.initials: GP
authors.lastname: Hemmings
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics; D002503:Centromere / Q000235:genetics; D002681:China; D062507:Claudin-5; D017931:DNA Primers / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D019901:Locus Control Region / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
chemical_list: C113571:CDC45 protein, human; C107466:CLDN5 protein, human; D018797:Cell Cycle Proteins; D062507:Claudin-5; D017931:DNA Primers; D008565:Membrane Proteins