[Effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine].
OBJECTIVE
To study the effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine.


METHODS
Sorbaria sorbifolia was perfused into stomach of rats with DEN-induced precancerosis, then the biochemical indexes were investigated. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and the concentrations of malondialdehyde (MDA), glutathione (GSH) were investigated by colorimetric method.


RESULTS
Sorbaria sorbifolia extract increased SOD, GSH-PX and decreased MDA, GSH levels in serum and liver homogenate.


CONCLUSIONS
Sorbaria Sorbifolia extract significantly increased anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine.
Zhang
Xue-Wu
XW
Department of Biochemistry & Molecular Biology, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, China. zlz2913835@sina.com
Sun
Quan
Q
Jin
Ming
M
Piao
Chun-Mei
CM
Li
Lian-Hua
LH
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004052:Diethylnitrosamine / Q000008:administration & dosage; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D027824:Rosaceae / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D004052:Diethylnitrosamine; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione