title: Eucaryotic replication origin binding proteins.
abstract: Initiation of eukaryotic DNA replication is a tightly controlled process. Replication initiates at multiple specific sites (replication origins) that have been licensed for replication, following the cell cycle-dependent, multi-step assembly of specific factors. Thus, replication origins occur in two chromatin states: a replication-competent pre-replicative (pre-RC) state, when a number of replication proteins assemble on the origin in a stepwise fashion, and a replication-incompetent post-replicative (post-RC) state, in which the origin (or elements of it) is bound only by the origin recognition complex (ORC) (or subunits of it). This review summarizes the origin binding proteins that have been have been identified to date.
authors.affiliation: McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada. maria.zannis@mcgill.ca
authors.forename: Maria
authors.initials: M
authors.lastname: Zannis-Hadjopoulos
authors.forename: Sahar
authors.initials: S
authors.lastname: Sibani
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Price
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism; D000818:Animals; D034961:Antigens, Nuclear / Q000737:chemistry; D002453:Cell Cycle; D002843:Chromatin / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000737:chemistry; D006801:Humans; D000072200:Ku Autoantigen; D051738:Origin Recognition Complex; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D048948:14-3-3 Proteins; D034961:Antigens, Nuclear; D002843:Chromatin; D004268:DNA-Binding Proteins; D051738:Origin Recognition Complex; D004247:DNA; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen