Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare.
Oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions and showed a central analgesic effect. Moreover, it significantly increased the plasma superoxide dismutase (SOD) and catalase activities and the high density lipoprotein-cholesterol level. On the contrary, the malondialdehyde (MDA) (as a measure of lipid peroxidation) level was significantly decreased in F. vulgare fruit methanolic extract group compared to the control group (P<0.05). These results seems to support the use of F. vulgare fruit methanolic extract in relieving inflammation.
Choi
Eun-Mi
EM
Department of Biotechnology and Bioproducts Research Center, Yonsei University, 330-326, Hongjae-dong, Seodaemun-gu, Seoul 120-091, South Korea.
Hwang
Jae-Kwan
JK
D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016718:Arachidonic Acid; D002351:Carrageenan; D002374:Catalase / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D030001:Foeniculum; D005638:Fruit; D006358:Hot Temperature; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D008076:Cholesterol, HDL; D010936:Plant Extracts; D016718:Arachidonic Acid; D002351:Carrageenan; D002374:Catalase; D013482:Superoxide Dismutase