title: Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency.
abstract: To examine leptin's role in human appetite regulation, we studied recombinant methionyl human leptin's effects on satiation and satiety in a model of leptin insufficiency, lipodystrophy. Eight females with hypoleptinemia and lipodystrophy were given sc injections of A-100 (maximal dose, 200% of that predicted to normalize serum leptin) for 4 months. Satiation and satiety were determined before and again during leptin treatment. Satiation was measured as the time to voluntary cessation of eating from a standardized food array after a 12-h fast. Satiety was determined as the time to hunger sufficient to consume a full meal after consumption of a standardized preload. During leptin treatment, satiation time decreased (41.2 +/- 18.2 to 19.5 +/- 10.6 min; P = 0.01), satiety time increased (62.9 +/- 64.8 to 137.8 +/- 91.6 min; P = 0.04), energy consumed to produce satiation decreased (2034 +/- 405 to 1135 +/- 432 kcal or 8.5 +/- 1.7 to 4.7 +/- 1.8 MJ; P < 0.01), and the amount of food desired in the postabsorptive state decreased (P < 0.02). Ghrelin concentrations also decreased during leptin administration (284.3 +/- 127.9 to 140.6 +/- 104.5 pmol/liter; P < 0.002). We conclude that increased leptin in patients with lipodystrophy results in less caloric, shorter, more satiating meals and longer-lived satiety. These data support the hypothesis that leptin plays an important, permissive role in human appetite regulation.
authors.affiliation: Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA. yanovskj@mail.nih.gov
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: McDuffie
authors.forename: Patti A
authors.initials: PA
authors.lastname: Riggs
authors.forename: Karim A
authors.initials: KA
authors.lastname: Calis
authors.forename: Renee J
authors.initials: RJ
authors.lastname: Freedman
authors.forename: Elif A
authors.initials: EA
authors.lastname: Oral
authors.forename: Alex M
authors.initials: AM
authors.lastname: DePaoli
authors.forename: Jack A
authors.initials: JA
authors.lastname: Yanovski
mesh_terms: D000293:Adolescent; D000328:Adult; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D020738:Leptin / Q000172:deficiency* / Q000627:therapeutic use*; D008060:Lipodystrophy / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D012527:Satiation / Q000187:drug effects*
chemical_list: D020738:Leptin