Multiple myeloma complicated by autoimmune hemolytic anemia.
A 57-year-old man was admitted with severe anemia and hypergamma globulinemia. After a diagnosis of multiple myeloma and autoimmune hemolytic anemia was made, chemotherapy rapidly decreased the M-protein level and improved his anemia with normalization of the direct Coombs test. The immunoglobulin binding to the patient's red cells was immunoglobulin G kappa chain like the myeloma M-protein. However, monoclonal immunoglobulin G derived from short-term culture of the patient's bone marrow mononuclear cells did not bind to a panel of red cells. Therefore, the relationship between the M protein produced by his myeloma cells and hemolysis remained unclear.
Wada
Hideho
H
Division of Hematology, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama.
Yata
Kenichiro
K
Mikami
Makoto
M
Suemori
Shinichiro
S
Nakanishi
Hidekazu
H
Kondo
Toshinori
T
Tsujioka
Takayuki
T
Suetsugu
Yoshimasa
Y
Otsuki
Takemi
T
Sadahira
Yoshito
Y
Yawata
Yoshihito
Y
Sugihara
Takashi
T
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000032:analysis; D001774:Blood Chemical Analysis; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis*; D009194:Myeloma Proteins / Q000032:analysis*; D018570:Risk Assessment; D012720:Severity of Illness Index
D014408:Biomarkers, Tumor; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins