title: Novel tetrahydro-thieno pyridyl oxazolidinone: an antibacterial agent.
abstract: Synthesis of a number of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine substituted oxazolidinones have been reported. They have been screened against a panel of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. A SAR has been developed. Compound 15 showed comparable activity (MIC) to linezolid and superior to eperezolid.
authors.affiliation: Zydus Research Centre, Cadila Healthcare Ltd, Sarkhej-Bavla N. H.8 A, Moraiya, Ahmedabad 382210, India. braj.lohray@zyduscadila.com
authors.forename: Braj Bhushan
authors.initials: BB
authors.lastname: Lohray
authors.forename: Vidya Bhushan
authors.initials: VB
authors.lastname: Lohray
authors.forename: Brijesh Kumar
authors.initials: BK
authors.lastname: Srivastava
authors.forename: Prashant B
authors.initials: PB
authors.lastname: Kapadnis
authors.forename: Purvi
authors.initials: P
authors.lastname: Pandya
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects*; D000069349:Linezolid; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D023303:Oxazolidinones / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D010080:Oxazoles; D023303:Oxazolidinones; D011725:Pyridines; C502706:tetrahydro-thieno pyridyl oxazolidinone; D014640:Vancomycin; C098011:eperezolid; D000069349:Linezolid; D008712:Methicillin