title: Effect of the synthetic polyamine N,N'-bis-(3-aminopropyl) cyclohexane-1,4-diamine (DCD) on rat spinal cord nociceptive transmission.
abstract: In rats submitted to a C-fiber reflex response paradigm, intravenous (i.v.) administration of 2.5, 5 and 10 mg/kg of the synthetic polyamine N,N'-bis-(3-aminopropyl) cyclohexane-1,4-diamine (DCD) dose-dependently reduced both the integrated C reflex responses and wind-up activity. Inhibitory effects of the polyamine on spinal cord nociceptive transmission are likely to be consequence of blockade by extracellular DCD of NMDA receptor channels localized in dorsal horn neurons, although modulatory actions at supraspinal level and at other ion channels could also be possible.
authors.affiliation: Garbil Pharma Investigación Chile, Room 402, Ave. Los Leones 382, Santiago, Chile. nbilbeny@ctcinternet.cl
authors.forename: Norberto
authors.initials: N
authors.lastname: Bilbeny
authors.forename: Carlos
authors.initials: C
authors.lastname: Paeile
authors.forename: Selfa
authors.initials: S
authors.lastname: Contreras
authors.forename: María
authors.initials: M
authors.lastname: Font
authors.forename: Hernán
authors.initials: H
authors.lastname: García
mesh_terms: D000818:Animals; D003510:Cyclohexanes / Q000008:administration & dosage / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D009474:Neurons / Q000187:drug effects; D009619:Nociceptors / Q000502:physiology*; D010147:Pain Measurement / Q000379:methods; D011073:Polyamines / Q000008:administration & dosage / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D003510:Cyclohexanes; C508894:N,N'-bis-(3-aminopropyl) cyclohexane-1,4-diamine; D011073:Polyamines