title: First catalytic asymmetric synthesis of beta-amino-beta-polyfluoroalkyl ketones via proline-catalysed direct asymmetric carbon-carbon bond formation reaction of polyfluoroalkylated aldimines.
abstract: Proline-catalysed direct asymmetric carbon-carbon bond formation reaction of polyfluoroalkylated aldimines with acetone afforded the corresponding beta-(p-methoxyphenyl)amino-beta-polyfluoroalkyl ketones in high enantioselectivities (up to 98% ee).
authors.affiliation: Department of Materials Science and Technology, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. kfunabik@apchem.gifu-u.ac.jp
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Funabiki
authors.forename: Masashi
authors.initials: M
authors.lastname: Nagamori
authors.forename: Sakiko
authors.initials: S
authors.lastname: Goushi
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsui
mesh_terms: D000588:Amines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis*; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D011108:Polymers; D002244:Carbon; D011392:Proline