title: Reduced intake of deoxynivalenol in The Netherlands: a risk assessment update.
abstract: In 1998 and 1999, wheat contained high levels of deoxynivalenol (DON) in The Netherlands. Eighty percent of the 1-year-old children exceeded the TDI (20% exceeded 2TDI). Assuming a long-term intake a negative effect on body weight might be possible. In 1999 the Dutch government took several risk management measures. We performed a probabilistic exposure and effect assessment and compared current and previous DON exposure and potential health effects for young children. The DON contamination of wheat was reduced for 50%. The estimated DON-intake was reduced to one-third of the previous levels. One-year-old children showed the highest DON-intake with a median of 0.46 microg/kgbw/day (95th percentile: 1.00 microg/kgbw/day). The probabilistic effect assessment showed that at the 95th percentile of DON-intake a reduced body weight was unlikely to exceed 9%. Taking into account the possible (partly) reversibility of this effect we conclude that no clear adverse health effects will be associated to the exposure (February 2000-December 2002) to DON in The Netherlands.
authors.affiliation: National Institute of Public Health and the Environment, RIVM, Centre for Substances and Integrated Risk Assessment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. mn.pieters@rivm.nl
authors.forename: Moniek N
authors.initials: MN
authors.lastname: Pieters
authors.forename: Martine
authors.initials: M
authors.lastname: Bakker
authors.forename: Wout
authors.initials: W
authors.lastname: Slob
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D002523:Edible Grain / Q000737:chemistry*; D005260:Female; D005506:Food Contamination / Q000032:analysis; D005517:Foodborne Diseases / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D051379:Mice; D008875:Middle Aged; D009426:Netherlands; D012044:Regression Analysis; D018570:Risk Assessment; D014255:Trichothecenes / Q000032:analysis* / Q000506:poisoning
chemical_list: D014255:Trichothecenes; C007262:deoxynivalenol