Roles of fascin in cell adhesion and motility.
Many cell interactions depend on the assembly of cell protrusions; these include cell attachment and migration in the extracellular matrix, cell-cell communication, and the ability of cells to sense their local environment. Cell protrusions are extensions of the plasma membrane that are supported internally by actin-based structures that impart mechanical stiffness. Fascin is a small, globular actin-bundling protein that has emerging roles in diverse forms of cell protrusions and in cytoplasmic actin bundles. The fascin-actin interaction is under complex regulation from the extracellular matrix, peptide factors and other actin-binding proteins. Recent developments advance our understanding of the multifaceted regulation of fascin and the roles of fascin-containing structures in cell adhesion, motility and invasion in the life of vertebrate organisms.
Adams
Josephine C
JC
Dept of Cell Biology, NC1-110, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. adamsj@ccf.org
D000199:Actins / Q000378:metabolism; D000818:Animals; D018407:Bacterial Physiological Phenomena; D002277:Carcinoma / Q000378:metabolism / Q000503:physiopathology; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology*; D007365:Intercellular Junctions / Q000502:physiology*; D008840:Microfilament Proteins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D014714:Vertebrates / Q000502:physiology*
D000199:Actins; D002352:Carrier Proteins; D008840:Microfilament Proteins; C020324:fascin