title: Can we really learn from model pathogens?
abstract: Cytolytic T (Tc) lymphocytes are the first order response of the adaptive immune system in the recovery from primary viral infections. These effector cells execute their function either by direct cytotoxicity through the Fas or perforin pathway and/or by the release of cytokines that either directly or indirectly exert antiviral activity. Mice respond to infection by closely related viruses with a vigorous Tc response, which is characterized by extensive crossreactivity on target cells infected with these viruses. However, the action of these cells can be beneficial, detrimental or neutral. From our current state of knowledge, no generalizations as to protective or detrimental effects of cytolytic effector functions in recovery from virus infections can be made. Thus, virus-host immune interactions have to be assessed individually and cannot be generalized.
authors.affiliation: Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia. Arno.Mullbacher@anu.edu.au <Arno.Mullbacher@anu.edu.au>
authors.forename: Arno
authors.initials: A
authors.lastname: Müllbacher
authors.forename: Matthias
authors.initials: M
authors.lastname: Regner
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Eva
authors.initials: E
authors.lastname: Lee
authors.forename: Mario
authors.initials: M
authors.lastname: Lobigs
authors.forename: Markus
authors.initials: M
authors.lastname: Simon
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D004195:Disease Models, Animal; D018178:Flaviviridae Infections / Q000276:immunology*; D005416:Flavivirus / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D018155:Orthopoxvirus / Q000276:immunology; D011213:Poxviridae Infections / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology