title: Influence of sterilization upon a range of properties of experimental bone cements.
abstract: Bone cement, used to fix prostheses into the bone, must be sterilized prior to implantation. Two sterilization techniques, gamma and beta radiation, were investigated, examining the influence upon molecular weight, static and dynamic mechanical characteristics and rheological properties. A number of experimental cements were studied prepared from methylmethacrylate (MMA) co-polymers, either single powders or powder blends, mixed with MMA monomer. It was found that with both gamma and beta radiation, there was a decrease in molecular weight of all powders, including a MMA/styrene co-polymer, in relation to the radiation dose. This fall in molecular weight resulted in a drop in tensile strength, Young's modulus and strain to failure of all cements tested. However, the deterioration in mechanical strength was highlighted by the dynamic testing. Fatigue lives of cements after testing in tension-tension, at 2 Hz under load control and irradiated with 25 kGy gamma radiation, displayed significant decreases. This result indicated the utmost importance of conducting such tests upon experimental bone cements prior to in vivo use. The rheological time profiles of curing cements were also found to be influenced by 25 kGy gamma radiation, with a reduction of complex viscosity after sterilization.
authors.affiliation: IRC in Biomedical Materials, Queen Mary and Westfield College, Mile End Road, London E1 4NS, UK.
authors.forename: E J
authors.initials: EJ
authors.lastname: Harper
authors.forename: M
authors.initials: M
authors.lastname: Braden
authors.forename: W
authors.initials: W
authors.lastname: Bonfield
authors.forename: E
authors.initials: E
authors.lastname: Dingeldein
authors.forename: H
authors.initials: H
authors.lastname: Wahlig