Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [3H]SB-269970.
The distribution of the 5-HT7 receptor was analyzed using the selective 5-HT7 receptor antagonist radioligand [3H]SB-269970 and human brain whole hemisphere autoradiography. The results indicated that 5-HT7 receptors are most abundantly localized in the anterior thalamus and in the dentate gyrus. Other regions containing intermediate levels of 5-HT7 receptors included the hypothalamus, anterior cingulate gyrus, hippocampus, amygdala and certain brainstem nuclei. The distribution pattern obtained in this study supports the involvement of this receptor subtype in affective behavior and cognition.
Varnäs
Katarina
K
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S-17176 Stockholm, Sweden.
Thomas
David R
DR
Tupala
Erkki
E
Tiihonen
Jari
J
Hall
Håkan
H
D000328:Adult; D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D010636:Phenols / Q000493:pharmacokinetics*; D011869:Radioligand Assay / Q000379:methods; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics*; D013449:Sulfonamides / Q000493:pharmacokinetics*; D014316:Tritium / Q000493:pharmacokinetics
D010636:Phenols; D011985:Receptors, Serotonin; C404922:SB 269970; D012702:Serotonin Antagonists; D013449:Sulfonamides; C104425:serotonin 7 receptor; D014316:Tritium