Apoptosis in lung injury and remodeling.
The mode of cell death termed apoptosis, sometimes referred to as programmed cell death, is as critical a determinant of cell population size as is cell proliferation. Although best characterized in cells of the immune system, apoptosis is now known to be a key factor in the maintenance of normal cell turnover within structural cells in the parenchyma of virtually every organ. Recent interest in apoptosis in the lung has sparked a surge of investigations designed to determine the roles of apoptosis in lung development, injury, and remodeling. Of particular recent interest are the roles of apoptosis in disease pathogenesis and resolution, in which the concept of apoptosis as a "programmed" cell death, i.e., genetically determined, is often more accurately viewed as "inappropriate cell suicide" with regard to its extent and/or timing. Data accumulating over the past decade have made clear the complexity of the control of lung cell apoptosis; concepts of the regulation of apoptosis originally determined in classical cell culture models are often, but not always, applicable to structural cells. For this reason, each of the many cell types of the lung must be studied as a potentially new subject with its own idiosyncrasies yet to be discovered. In light of the large volume of literature now available, this article focuses on the roles of apoptosis in three pathophysiological contexts: acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis. Each section presents key data describing the evidence for apoptosis in the lung, its possible relevance to disease pathogenesis, and proposed mechanisms that might suggest potential avenues for therapeutic intervention.
Li
Xiaopeng
X
Dept. of Physiology, Michigan State University, 3185 Biomedical and Physical Sciences Bldg., East Lansing, MI 48824, USA.
Shu
Ruijie
R
Filippatos
Gerasimos
G
Uhal
Bruce D
BD
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D055370:Lung Injury; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D011658:Pulmonary Fibrosis / Q000503:physiopathology*; D020127:Recovery of Function / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*