Chemoselective cyclizations of divinyl ketones to cyclohexenones mediated by Lewis acid and base.
[reaction: see text] Chemoselective cyclizations of divinyl ketones to cyclohexenones mediated by a sterically demanding Lewis acid and an amine base have been accomplished under mild reaction conditions. The extension of this methodology to the synthesis of eight-membered rings is also demonstrated.
Magomedov
Nabi A
NA
Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, USA. magomedov@chem.rochester.edu
Ruggiero
Piero L
PL
Tang
Yuchen
Y