Risk of thyroid cancer in the Bryansk Oblast of the Russian Federation after the Chernobyl Power Station accident.
This population-based case-control study investigated whether exposure to radiation from the Chernobyl Power Station accident is associated with an increased risk of thyroid cancer in children and adolescents aged 0-19 years at the time of the accident who were residing in the more highly contaminated areas of the Bryansk Oblast. Cases were diagnosed with thyroid cancer before October 1, 1997 (n = 26); two controls per case were identified from the Russian State Medical Dosimetrical Registry and were matched by gender, birth year, and raion of residence and type of settlement (urban, town, rural) on April 26, 1986 (n = 52). Individual radiation doses to the thyroid were estimated using a semi-empirical model and data were collected in interviews, primarily of the participants' mothers. Based on a loglinear dose-response model treating estimated dose as a continuous variable, the trend of increasing risk with increasing dose was statistically significant (one-sided P = 0.009). These data suggest that exposure to radiation from Chernobyl is associated with an increased risk of thyroid cancer, and that the relationship is dependent on dose. These findings are consistent with descriptive reports from contaminated areas of Ukraine and Belarus, and the quantitative estimate of thyroid cancer risk is generally consistent with estimates from other radiation-exposed populations.
Davis
Scott
S
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA. sdavis@fhcrc.org
Stepanenko
Valery
V
Rivkind
Nikolai
N
Kopecky
Kenneth J
KJ
Voillequé
Paul
P
Shakhtarin
Vladimir
V
Parshkov
Evgeni
E
Kulikov
Sergei
S
Lushnikov
Evgeni
E
Abrosimov
Alexander
A
Troshin
Vladislav
V
Romanova
Galina
G
Doroschenko
Vladimir
V
Proshin
Anatoli
A
Tsyb
Anatoly
A
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000396:Air Pollutants, Radioactive / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011210:Power Plants; D011829:Radiation Dosage; D011847:Radioactive Fallout / Q000032:analysis*; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D017678:Sex Distribution; D013964:Thyroid Neoplasms / Q000453:epidemiology*; D014455:Ukraine
D000396:Air Pollutants, Radioactive; D011847:Radioactive Fallout