title: What is acute disseminated encephalomyelitis (ADEM)?
abstract: Acute demyelinating encephalomyelitis (ADEM) is increasingly recognized but difficult to define precisely: eleven papers have recently been published that used different definitions. Several diseases, most of them relapsing, can mimic ADEM at onset and require specific treatments. First, the distinction between early signs of multiple sclerosis and ADEM is controversial in the absence of specific biological characterization. To clarify it, epidemiological evaluations on large groups of children, of calculated risk factors for the occurrence of relapses after a first demyelinating event are probably the best approach. Macrophage activation syndrome and different types of angiitis may mimic ADEM, because they can occur in the absence of the usual non neurological symptoms. Both entities require specific treatments.
authors.affiliation: Neurologie pédiatrique, Hôpital Bicêtre, Assistance publique, Hôpitaux de Paris, 78 rue du général Leclerc, 94275 Le Kremlin Bicêtre cedex, France. marc.tardieu@bct.ap-hop-paris.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Tardieu
authors.forename: Yann
authors.initials: Y
authors.lastname: Mikaeloff
mesh_terms: D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000628:therapy; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis; D006801:Humans; D008262:Macrophage Activation; D009103:Multiple Sclerosis / Q000175:diagnosis; D013577:Syndrome; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis