title: [Hemostatic and analgesic effect of Gonghuan Zhixue Tablet on mice].
abstract: OBJECTIVE
  To explore the hemostatic and analgesic effect of Gonghuan Zhixue Tablet (GHZXT) on mice and to produce experimental evidence for exploiting new drug for endometrorrhagia caused by Cu-intrauterine contraceptive device (Cu-IUD).
  
  
  METHODS
  Compared with 6-aminocaproic acid and notoginseng, the effects of GHZXT on clotting and bleeding time of mice with capillary method and severed tail were investigated; and compared with aspirin, the analgesic effects of GHZXT on mice were investigated with hot plate and torsive body method.
  
  
  RESULTS
  The clotting time of mice was remarkably shortened with a rising of the dosage of GHZXT and the difference between each therapeutic group and distilled water group was remarkable. As compared with distilled water group, the bleeding time of each dosage group of GHZXT was obviously shortened; and each dosage of GHZXT could prolong the time of pain reaction to hot plate and decrease the degree of torsive body of the mice.
  
  
  CONCLUSIONS
  Pharmacological experiment has proved that GHZXT has evident hemostatic and analgesic function.
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, Hunan College of Traditional Chinese Medicine, Changsha, Hunan Province 410007, China. flm1208@163.com
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Fu
authors.forename: Zhao-Ling
authors.initials: ZL
authors.lastname: You
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Le-Xi
authors.initials: LX
authors.lastname: Wen
authors.forename: Huan-Ming
authors.initials: HM
authors.lastname: Chen
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006490:Hemostatics / Q000494:pharmacology*; D007434:Intrauterine Devices / Q000009:adverse effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D013607:Tablets; D014914:Whole Blood Coagulation Time
chemical_list: D000700:Analgesics; D006490:Hemostatics; D013607:Tablets