Dysinosins B-D, inhibitors of factor VIIa and thrombin from the Australian sponge Lamellodysidea chlorea.
Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin.
Carroll
Anthony R
AR
Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, Queensland, Australia 4111.
Buchanan
Malcolm S
MS
Edser
Annette
A
Hyde
Edward
E
Simpson
Moana
M
Quinn
Ronald J
RJ
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D015942:Factor VIIa / Q000037:antagonists & inhibitors*; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000925:Anticoagulants; D007211:Indoles; D011758:Pyrroles; C470588:dysinosin A; C492311:dysinosin B; C492312:dysinosin C; C492313:dysinosin D; D015942:Factor VIIa; D013917:Thrombin