From mRNA to tumor suppressor.
The combination of inhibition of RNA degradation and comparative genomic scanning is a powerful new method for detecting gene disruptions. The utility of the method is well-illustrated by a series of observations linking the ephrin receptor EPHB2 to prostate cancer.
Mercola
Dan
D
Welsh
John
J
D004640:Emetine / Q000494:pharmacology; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*; D020871:RNA Stability; D012333:RNA, Messenger; D036183:Receptor, EphB2 / Q000235:genetics
D012333:RNA, Messenger; D036183:Receptor, EphB2; D004640:Emetine