[Clinical observation on treatment of nonalcoholic fatty liver disease complicating hyperuricemia by Zhifang I Decoction].
OBJECTIVE
To observe the therapeutic effect of Chinese herbal recipe Zhifang I Decoction on nonalcoholic fatty liver disease (NAFLD) complicating hyperuricemia (HUA).


METHODS
Forty-six patients suffering from NAFLD complicating HUA were randomly divided into treatment group (25 cases) with Zhifang I and control group (21 cases) with Xuezhikang Capsule. One course of treatment was 8 weeks. The data were processed by SPSS 11.0 statistical package after 2 courses of treatment.


RESULTS
The total effective rate of the treatment group was 80.00%, which surpassed the control group (71.43%) (P<0.01); Zhifang I could improve the image of B-mode ultrasonography and was better than Xuezhikang in ameliorating the clinical symptoms (P<0.05); Zhifang I could significantly decrease the serum uric acid (UA) (P<0.01), while Xuezhikang had no obvious therapeutic effect on it (P>0.05); Zhifang I was as good as Xuezhikang in recovering alanine aminotransferase (ALT), aspartate aminotransferase (AST),gamma-glutamyltransferase (gamma-GT), total cholesterol (TC) and triglyceride (TG) (P>0.05).


CONCLUSIONS
Zhifang I has good effect in treating NAFLD complicating HUA.
Zhang
Xiao-Yi
XY
Department of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghi 200021, China.
Kuang
Cheng-Bao
CB
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy*; D005260:Female; D043384:Glutamyl Aminopeptidase / Q000097:blood / Q000378:metabolism; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy* / Q000209:etiology; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019370:Observation; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D014463:Ultrasonography; D014527:Uric Acid / Q000097:blood / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D014280:Triglycerides; D014527:Uric Acid; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D043384:Glutamyl Aminopeptidase