A novel role for vernix caseosa as a skin cleanser.
OBJECTIVE
Skin cleansing is a complex process involving endogenous and exogenous mechanisms. This study examines the role of vernix caseosa in the process of skin cleansing in the perinatal period.


METHODS
Vernix was evaluated as an exogenously applied skin cleanser using digitized image analysis which quantified residual carbon particles following a standardized cleansing assay. In addition, the detachment of vernix from human cadaveric skin and Gore-Tex supports was investigated following timed exposures to a variety of commonly used commercial surfactants. Detachment was quantified spectrophotometrically as increased turbidity at 650 nm.


RESULTS
Image analysis showed that exogenous application of vernix exhibited a cleansing capability comparable or superior to standard skin cleansers. Dose-dependent increases in solution turbidity (vernix detachment) were seen following exposure of vernix-covered Gore-Tex vehicles to sodium laureth sulfate, sodium lauryl sulfate, and cocamidopropyl betaine solutions. Similar results were seen with cadaveric skin.


CONCLUSIONS
These results demonstrate a role for vernix caseosa as a skin cleanser. Previous views of vernix as a soil or skin contaminant at birth need to be reevaluated.
Moraille
R
R
Division of Neonatology and Skin Sciences Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Pickens
W L
WL
Visscher
M O
MO
Hoath
S B
SB
D002102:Cadaver; D003902:Detergents; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D009391:Nephelometry and Turbidimetry; D011138:Polytetrafluoroethylene; D017592:Skin Care; D012984:Software; D012996:Solutions; D013501:Surface-Active Agents; D014708:Vernix Caseosa / Q000502:physiology*
D003902:Detergents; D012996:Solutions; D013501:Surface-Active Agents; D011138:Polytetrafluoroethylene