title: Intra-articular oxidative state correlated with the pathogenesis of disorders of the temporomandibular joint.
abstract: We investigated the redox state of albumin in the synovial fluid from patients with temporomandibular joint (TMJ) disorders (TMD) to evaluate the relation between the cause of the TMD and the number of types of oxygen in synovial fluid. The albumin was fractionated into three components, human mercaptalbumin (HMA, reduced form) and two types human non-mercaptalbumin (HNA, oxidized form), by high-performance liquid chromatography (HPLC). The 63 patients were divided into three groups radiologically, and the ratios of the redox state of the synovial fluid in each group were compared. The fraction of HNA was significantly higher in patients with advanced disease than in patients with early disease. This indicates that the TMJ is affected by intra-articlular oxidative stress, and the severity of TMD correlates closely with the number of oxidative factors. Oxidative stress was thought to be responsible for the genesis of TMD.
authors.affiliation: Department of Physiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. mtomi@research.twmu.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Tomida
authors.forename: J I
authors.initials: JI
authors.lastname: Ishimaru
authors.forename: K
authors.initials: K
authors.lastname: Murayama
authors.forename: T
authors.initials: T
authors.lastname: Kajimoto
authors.forename: M
authors.initials: M
authors.lastname: Kurachi
authors.forename: S
authors.initials: S
authors.lastname: Era
authors.forename: T
authors.initials: T
authors.lastname: Shibata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis*; D002853:Chromatography, Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011859:Radiography; D017382:Reactive Oxygen Species / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis; D013582:Synovial Fluid / Q000378:metabolism*; D013705:Temporomandibular Joint Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*
chemical_list: D000418:Albumins; D017382:Reactive Oxygen Species; D012709:Serum Albumin; C001702:mercaptoalbumin