title: BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration.
abstract: The present study examined the modulating effects of an intrahippocampal injection of interleukin-1beta (IL-1beta) on brain-derived neurotrophic factor (BDNF) mRNA expression 0.5, 2, 4, and 6 h following contextual fear conditioning, a task known to increase BDNF mRNA, in rats. Contextual fear conditioning produced a time-dependent increase in BDNF mRNA that varied by region of hippocampus. IL-1beta blocked or reduced these increases in BDNF mRNA in the CA1, CA2, and dentate gyrus regions of the hippocampus, but had no effect in cortical regions. These data support the idea that IL-1beta-produced memory deficits may be mediated via BDNF mRNA reductions in hippocampus.
authors.affiliation: Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309, USA. rbarr@psych.colorado.edu
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Barrientos
authors.forename: David B
authors.initials: DB
authors.lastname: Sprunger
authors.forename: Serge
authors.initials: S
authors.lastname: Campeau
authors.forename: Linda R
authors.initials: LR
authors.lastname: Watkins
authors.forename: Jerry W
authors.initials: JW
authors.lastname: Rudy
authors.forename: Steven F
authors.initials: SF
authors.lastname: Maier
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D018891:Dentate Gyrus / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D004333:Drug Administration Routes; D005239:Fear / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000276:immunology* / Q000503:physiopathology; D007375:Interleukin-1 / Q000276:immunology* / Q000494:pharmacology; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008569:Memory Disorders / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D007375:Interleukin-1; D012333:RNA, Messenger