Hydroxypatite-polysaccharide granules for drug delivery.
The formation of hydroxyapatite by co-precipitation from sodium alginate and sodium carboxymethylcellulose aqueous solutions with the use of dibasic calcium phosphate dihydrate and calcium hydroxide as starting reagents is studied. A technique to prepare the hydroxyapatite/polysaccharide (micro)granules is developed. An introduction of an antimicrobial Biocide 1 agent in proper amount into the granules is provided, and the behavior of the granules is evaluated.
Krylova
E
E
Scientific and Technology Center Spectrum RAS and RAES, Leninskij pr. 31, Moscow, 117907, Russia.
Ivanov
A
A
Orlovski
V
V
El-Registan
G
G
Barinov
S
S