Genetic aspects of Alzheimer's disease, Pick's disease, and other dementias.
Although genetic testing is available for some degenerative diseases, in most types of dementia, both genetic and environmental factors are involved. Overall, dementing diseases can be either sporadic or inherited, and in general, the earlier the onset, the more likely a disease is to be inherited. Before genetic testing is performed, the ethical issues, such as the effect the tests might have on asymptomatic children, should be considered. The ethical use of DNA samples in research is another genetic testing issue to be considered.
Nee
Linda E
LE
Family Studies Unit, National Institute of Neurological Disorders and Stroke, Clinical Center, Bethesda, Maryland, USA. neel@ninds.nih.gov
Tierney
Michael C
MC
Lippa
Carol F
CF
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000235:genetics*; D003704:Dementia / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics; D005823:Genetics / Q000941:ethics*; D005838:Genotype; D006801:Humans; D020961:Lewy Body Disease / Q000453:epidemiology / Q000235:genetics*; D008403:Mass Screening / Q000379:methods; D020774:Pick Disease of the Brain / Q000453:epidemiology / Q000235:genetics*; D017096:Prion Diseases / Q000453:epidemiology / Q000235:genetics*