title: TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression.
abstract: Life expectancy for patients suffering from prostate cancer is inversely correlated with the degree of extraprostatic metastasis. In order to find pharmacological tools to treat this aggressive growth it is important to define targets whose expression not only correlates with the malignancy of the cancerous cells, but that are also amenable to pharmacological intervention. In this review, we would like to focus on the potential role of a distinct class of ion channels that may be involved in this process.
authors.affiliation: Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Universität des Saarlandes, D-66421 Homburg, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wissenbach
authors.forename: Barbara
authors.initials: B
authors.lastname: Niemeyer
authors.forename: Nina
authors.initials: N
authors.lastname: Himmerkus
authors.forename: Thomas
authors.initials: T
authors.lastname: Fixemer
authors.forename: Helmut
authors.initials: H
authors.lastname: Bonkhoff
authors.forename: Veit
authors.initials: V
authors.lastname: Flockerzi
mesh_terms: D015220:Calcium Channels / Q000378:metabolism* / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D050916:TRPV Cation Channels
chemical_list: D015220:Calcium Channels; D050916:TRPV Cation Channels; C120776:TRPV6 channel