Cutaneous gammadelta T cells-selecting a destination and asking for directions in the thymus.
T cell receptor-defined subsets of gammadelta T cells differentially localize in cutaneous, intestinal, or reproductive epithelium. In this issue of Immunity, Xiong et al. show that murine Vgamma3+ T cells undergo TCR-dependent selection in the fetal thymus that drives expression of a cutaneous homing receptor.
Campbell
Daniel J
DJ
Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101, USA.
D000818:Animals; D002465:Cell Movement; D051379:Mice; D008822:Mice, Transgenic; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D016201:Receptors, Lymphocyte Homing / Q000502:physiology; D012867:Skin / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology* / Q000502:physiology*
D016692:Receptors, Antigen, T-Cell, gamma-delta; D016201:Receptors, Lymphocyte Homing