Transplantation of human umbilical cord blood cells improves glycemia and glomerular hypertrophy in type 2 diabetic mice.
Recent in vitro and in vivo studies have shown that either animal- or human-derived embryonic stem cells can differentiate into insulin-secreting cells and lower blood glucose levels. However, studies utilizing human umbilical cord blood (HUCB) mononuclear cells to improve blood glucose levels in diabetic animals have received little attention. In this study, we examined the effect of transplanted HUCB mononuclear cells on blood glucose levels, survival, and renal pathology in obese mice with spontaneous development of type 2 diabetes. The results show that injection of HUCB mononuclear cells into orbital plexus of mice caused improvement not only in blood glucose levels and survival rate but also normalization of glomerular hypertrophy and tubular dilatation. Thus, transplantation of HUCB mononuclear cells appears to be another modality of stem cell therapy in diabetes mellitus.
Ende
Norman
N
Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.
Chen
Ruifeng
R
Reddi
Alluru S
AS
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000628:therapy*; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D006984:Hypertrophy; D007678:Kidney Glomerulus / Q000473:pathology*; D051379:Mice; D009765:Obesity; D033581:Stem Cell Transplantation / Q000379:methods*; D016019:Survival Analysis; D014183:Transplantation, Heterologous / Q000502:physiology*
D001786:Blood Glucose