Intermittent claudication -- atypical presentation, diagnosis and treatment.
A unique case of a man with Fabry's disease and associated small vessel vasculopathy manifesting as recurrent episodes of intermittent claudication is described. The case highlights the concept that microvascular involvement due to local accumulation of glycosphingolipid in the smooth muscle fibres of vessel walls may be responsible for claudicant symptoms in such patients rather than the more classical macrovascular insufficiency.
Taylor
I
I
Department of Neurology, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia. i.taylor@bigpond.com
Dennett
X
X
Nicholls
K
K
Tubridy
N
N
D042783:Endothelial Cells / Q000473:pathology / Q000648:ultrastructure; D000795:Fabry Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007383:Intermittent Claudication / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D014281:Trihexosylceramides
D014281:Trihexosylceramides; C018549:globotriaosylceramide