title: [Immunostimulating activity of polycomponent vaccine "Immunovac-VP-4" and grippol after their combined administration].
abstract: The experimental study of the immunostimulating activity of therapeutic bacterial polycomponent vaccine VP-4 and prophylactic vaccine grippol, introduced both separately and in combination, on mice infected with Salmonella typhimurium, used as a model. Both preparations were found to produce an immunomodulating effect. The combined subcutaneous injection of VP-4 and grippol did not decrease their immunostimulating activity, but their separate administration at an interval of 14 days resulted in essential decrease in the protective activity of each of these two preparations. As shown on the model of Klebsiella infection in mice, challenged 4 weeks after immunization, VP-4 ensured the survival of 78.6% of mice, while after the injection of grippol their survival rate was not different from that of the group of intact animals. The evaluation of the immunostimulating activity of these preparations under the conditions of the prophylaxis of influenza and acute respiratory infections in organized groups of children revealed that the use of VP-4 alone or grippol in combination with VP-4 considerably decreased the number of secondary bacterial complications in children.
authors.forename: E A
authors.initials: EA
authors.lastname: Kurbatova
authors.forename: B F
authors.initials: BF
authors.lastname: Semenov
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
authors.forename: V N
authors.initials: VN
authors.lastname: Efremova
authors.forename: I M
authors.initials: IM
authors.lastname: Gruber
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
authors.forename: O M
authors.initials: OM
authors.lastname: Kushchenko
mesh_terms: D000208:Acute Disease; D000818:Animals; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D002648:Child; D004195:Disease Models, Animal; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control; D007279:Injections, Subcutaneous; D007709:Klebsiella; D007710:Klebsiella Infections / Q000517:prevention & control; D051379:Mice; D012141:Respiratory Tract Infections / Q000150:complications / Q000517:prevention & control; D012480:Salmonella Infections / Q000517:prevention & control*; D012486:Salmonella typhimurium; D013997:Time Factors; D014611:Vaccination; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; C408342:Grippol; D007155:Immunologic Factors; D007252:Influenza Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined; D022223:Vaccines, Subunit