title: [An experimental study on distribution of musk into the brain through blood brain barrier].
abstract: OBJECTIVE
  To study the possible pathway of the effect of musk on brain disorder, distributing into the brain through blood brain barrier.
  
  
  METHODS
  We used the musk ketone (muscone), a main composition of musk, to inject through the tail vein of the rats into the blood and took the brain and other organs at different times to make samples. Then gas chromatography was used to measure the distribution of muscone in the brain and other organs.
  
  
  RESULTS
  Muscone could pass through the normal rat's blood brain barrier into the brain and soon reached the highest peak and remained in higher concentration, and more slowly metabolized as compared with other organs.
  
  
  CONCLUSIONS
  Musk distributing into the brain through blood brain barrier provides the basis for its effect in treating brain disorders. Chromatography is an effective method to study the active composition of Chinese herbal medicine distributing through the blood brain barrier into the brain.
authors.affiliation: Division of Zang-fu Organs' Research, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China. cwenkai@public1.ptt.js.cn
authors.forename: Wen-Kai
authors.initials: WK
authors.lastname: Chen
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Huang
authors.forename: Hai-Dong
authors.initials: HD
authors.lastname: Wang
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002849:Chromatography, Gas; D003516:Cycloparaffins / Q000493:pharmacokinetics; D005229:Fatty Acids, Monounsaturated / Q000493:pharmacokinetics*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003516:Cycloparaffins; D005229:Fatty Acids, Monounsaturated; C008563:musk; C031021:muscone