title: Age-specific immune response to HspA in Helicobacter pylori-positive persons in Mexico.
abstract: The immune response to heat shock protein A (HspA) in Helicobacter pylori-positive adults increases with age in developed countries. This response has not been studied with children or in developing countries (G. I. Pérez-Pérez, J. M. Thiberge, A. Labigne, and M. J. Blaser, J. Infect. Dis. 174:1046-1050, 1996). As determined by using a specific enzyme-linked immunosorbent assay, HspA seropositivity among 592 individuals in Mexico was <10% in children and increased to >40% in adults.
authors.affiliation: Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Eamranond
authors.forename: Javier
authors.initials: J
authors.lastname: Torres
authors.forename: Onofre
authors.initials: O
authors.lastname: Muñoz
authors.forename: Guillermo I
authors.initials: GI
authors.lastname: Pérez-Pérez
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000917:Antibody Formation; D001426:Bacterial Proteins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006360:Heat-Shock Proteins / Q000276:immunology*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D016480:Helicobacter pylori; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016555:Matched-Pair Analysis; D008800:Mexico; D008875:Middle Aged; D012698:Serologic Tests
chemical_list: D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; C113725:HspA protein, bacteria