title: Effects of malnutrition on cytochrome P450 1A2 activity in elderly patients.
abstract: Little is known of the influence of nutritional status on cytochrome P450 (CYP) 1A2 activity in elderly patients. Thirty elderly institutionalised patients with malnutrition (group A, aged 88 +/- 5 years) and 24 without (group B, aged 81 +/- 9 years) were included. Malnutrition was defined as weight loss of >10% over the previous 6 months and/or a body mass index (BMI) <21 kg/m2 and albuminaemia < or = 32 g/L. CYP1A2 activity was evaluated by the plasma paraxanthine/caffeine (PAX/CAF) metabolic ratio. The plasma PAX/CAF metabolic ratio was similar in both groups regardless of nutritional status (0.34 +/- 0.13 [A] versus 0.30 +/- 0.11 [B]; p = 0.11). The CYP1A2 metabolic ratio was not correlated to either BMI, serum albumin or renal clearance. CYPI A2 activity, as measured by the plasma PAX/CAF ratio, was not influenced by nutritional status in elderly patients.
authors.affiliation: Département de Gériatrie, Hôpital Charles Foix, Ivry-sur-Seine, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Hamon-Vilcot
authors.forename: Tabassome
authors.initials: T
authors.lastname: Simon
authors.forename: Laurent
authors.initials: L
authors.lastname: Becquemont
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Poirier
authors.forename: François
authors.initials: F
authors.lastname: Piette
authors.forename: Patrice
authors.initials: P
authors.lastname: Jaillon
mesh_terms: D000368:Aged / Q000502:physiology*; D000369:Aged, 80 and over; D002110:Caffeine; D019363:Cytochrome P-450 CYP1A1 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000201:enzymology*; D008875:Middle Aged; D009752:Nutritional Status; D010641:Phenotype; D010726:Phosphodiesterase Inhibitors
chemical_list: D010726:Phosphodiesterase Inhibitors; D002110:Caffeine; D019363:Cytochrome P-450 CYP1A1