title: [Anticholinergic Effect of a New Antiarrhythmic Class III Drug RG-2].
abstract: In experiments on isolated rat and rabbit right atrium, a new class III antiarrhythmic drug RG-2 (0,01-1 microM) was shown to have anticholinergic action competing with 0.2-1 mM carbachol. RG-2 (0.1-1 microM) produced dose-dependent increase of APD90% in rat and rabbit atrial cells and had no effects on other action potential parameters. In presence of carbachol RG-2 produced significantly greater increase of APD90% and caused significant increase of APD50%. Thus RG-2 exerts anticholinergic action, which can take important part in RG-2 antiarrhythmic activity.
authors.affiliation: Cardiology Research Complex; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Fedorov
authors.forename: I A
authors.initials: IA
authors.lastname: Ivanova
authors.forename: A V
authors.initials: AV
authors.lastname: Glukhov
authors.forename: A V
authors.initials: AV
authors.lastname: Reznik
authors.forename: L V
authors.initials: LV
authors.lastname: Rozenshtraukh
authors.forename: S P
authors.initials: SP
authors.lastname: Golitsyn
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Ruda
authors.forename: E I
authors.initials: EI
authors.lastname: Chazov
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D018680:Cholinergic Antagonists; D006325:Heart Atria / Q000187:drug effects
chemical_list: D000889:Anti-Arrhythmia Agents; D018680:Cholinergic Antagonists