title: Multiple myeloma complicated by autoimmune hemolytic anemia.
abstract: A 57-year-old man was admitted with severe anemia and hypergamma globulinemia. After a diagnosis of multiple myeloma and autoimmune hemolytic anemia was made, chemotherapy rapidly decreased the M-protein level and improved his anemia with normalization of the direct Coombs test. The immunoglobulin binding to the patient's red cells was immunoglobulin G kappa chain like the myeloma M-protein. However, monoclonal immunoglobulin G derived from short-term culture of the patient's bone marrow mononuclear cells did not bind to a panel of red cells. Therefore, the relationship between the M protein produced by his myeloma cells and hemolysis remained unclear.
authors.affiliation: Division of Hematology, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama.
authors.forename: Hideho
authors.initials: H
authors.lastname: Wada
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yata
authors.forename: Makoto
authors.initials: M
authors.lastname: Mikami
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Suemori
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nakanishi
authors.forename: Toshinori
authors.initials: T
authors.lastname: Kondo
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tsujioka
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Suetsugu
authors.forename: Takemi
authors.initials: T
authors.lastname: Otsuki
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Sadahira
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Yawata
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugihara
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000032:analysis; D001774:Blood Chemical Analysis; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis*; D009194:Myeloma Proteins / Q000032:analysis*; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D014408:Biomarkers, Tumor; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins