Ovarian hemangioma presenting with hyperandrogenism and endometrial cancer: a case report.
BACKGROUND
Hemangiomas are very rare tumors of the ovary. Here, we report a case of a mixed capillary and cavernous ovarian hemangioma and endometrial carcinoma presenting with postmenopausal bleeding, male pattern receding frontal hairline, and high serum androgen and estradiol levels.


METHODS
A 70-year-old White female underwent laparotomy for endometrial carcinoma. Intraoperative frozen-section examination of the uterus revealed a 3.5 x 3 cm, grade 1 endometrioid adenocarcinoma of the endometrium with more than 50% myometrial invasion. The left ovary contained a 1.5 x 1 x 1 cm, well-circumscribed hemorrhagic nodule on the cut surface. Final histopathological examination of the small nodule demonstrated multiple, enlarged, blood-filled vascular channels lined by a single layer of flattened regular endothelial cells with no atypical features. Vascular spaces within the tumor were of different sizes, ranging from small to large, and were separated by connective tissue. The surrounding ovarian stroma was hyperplastic and contained clusters of luteinized stromal cells. Microscopy of the right ovary showed minimal stromal proliferation and no luteinization of the ovarian stroma.


CONCLUSIONS
This is the first case of an ovarian hemangioma synchronous with a well-differentiated endometrial carcinoma. Absence of estrogen and progesterone receptors in the endothelial cells of the hemangioma suggests that ovarian hemangiomas may occur independent of stimulation by estrogen and progesterone.
Gücer
Fatih
F
Department of Obstetrics and Gynecology, Faculty of Medicine, Trakya University, Edirne, Turkey. fgucer@yahoo.com
Ozyilmaz
Filiz
F
Balkanli-Kaplan
Petek
P
Mülayim
Naciye
N
Aydin
Ozgür
O
D000368:Aged; D000728:Androgens / Q000097:blood; D018269:Carcinoma, Endometrioid / Q000097:blood / Q000150:complications* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005260:Female; D006392:Hemangioma, Cavernous / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000473:pathology; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D017698:Postmenopause; D014592:Uterine Hemorrhage / Q000209:etiology
D000728:Androgens; D004958:Estradiol