title: [KatG Ser3 15Thr mutation as the main reason of isoniazid resistance in Mycobacterium tuberculosis isolated in the Novosibirsk and Kemerovo Regions].
abstract: KatG Ser3 15Thr mutation is one of the main reasons of resistance to isoniazid in Mycobacterium tuberculosis isolates. The frequency rate of the above mutation among isoniazid-resistant isolates made 94% in Novosibirsk Region and 93% in Kemerovo Region. The use of PCR-restriction fragment length polymorphism (PCR-RFLP) can be regarded as an adequate method for rapid screening of isoniazid resistance in Mycobacterium tuberculosis isolated in the West-Siberian Region.
authors.forename: E N
authors.initials: EN
authors.lastname: Voronina
authors.forename: M A
authors.initials: MA
authors.lastname: Vikhrova
authors.forename: E A
authors.initials: EA
authors.lastname: Khrapov
authors.forename: V N
authors.initials: VN
authors.lastname: Kinsht
authors.forename: O V
authors.initials: OV
authors.lastname: Norkina
authors.forename: E V
authors.initials: EV
authors.lastname: Gorbunova
authors.forename: A V
authors.initials: AV
authors.lastname: Shabaldin
authors.forename: A N
authors.initials: AN
authors.lastname: Glushkov
authors.forename: V A
authors.initials: VA
authors.lastname: Krasnov
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D000995:Antitubercular Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D002374:Catalase / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008875:Middle Aged; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D012694:Serine; D012800:Siberia; D013912:Threonine
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D013912:Threonine; D012694:Serine; D002374:Catalase; C480353:katG protein, Mycobacterium tuberculosis; D007538:Isoniazid