title: Disseminated infection with Balamuthia mandrillaris in a dog.
abstract: Bilateral chronic granulomatous nephritis and meningoencephalitis were diagnosed on necropsy of a 2-year-old male Great Dane dog. The causative agent was identified as Balamuthia mandrillaris, based on morphologic features, immunohistochemical staining, and deoxyribonucleic acid detection using the polymerase chain reaction with newly designed primer pairs. Trophozoite and cystic forms of the amoeba were evident within the kidneys and brain parenchyma. This is the first report on a B. mandrillaris infection in a dog.
authors.affiliation: oded@vmth.ucdavis.edu
authors.forename: O
authors.initials: O
authors.lastname: Foreman
authors.forename: J
authors.initials: J
authors.lastname: Sykes
authors.forename: L
authors.initials: L
authors.lastname: Ball
authors.forename: N
authors.initials: N
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: De Cock
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D020808:Central Nervous System Protozoal Infections / Q000473:pathology / Q000662:veterinary*; D017931:DNA Primers; D004283:Dog Diseases / Q000469:parasitology* / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D007668:Kidney / Q000473:pathology; D016840:Lobosea / Q000235:genetics*; D008297:Male; D009393:Nephritis / Q000473:pathology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011528:Protozoan Infections / Q000473:pathology; D011529:Protozoan Infections, Animal
chemical_list: D017931:DNA Primers