title: Implications of orthopedic fretting corrosion particles on skeletal muscle microcirculation.
abstract: Particulate corrosion and wear products of metal implants are increasingly becoming topics of interest, due to the cascade of biological and biomechanical events they induce. The impairment of skeletal muscle microcirculation by fretting corrosion particles may have profound consequences. We therefore studied in vivo leukocyte-endothelial cell interaction in skeletal muscle after confrontation with characterized titanium and stainless steel fretting corrosion particles, and compared these results with those of the bulk materials. Using the hamster dorsal skinfold chamber preparation and intravital microscopy, we could demonstrate that stainless steel induces a more pronounced inflammatory answer in contrast to the implant material titanium. However, we were not able to show a general benefit of bulk vs. debris. Overall, the study suggests that not only the bulk properties of orthopaedic implants, but also the microcirculatory implications of inevitable wear debris, may play a role in determining biocompatibility and ultimately longevity of an implant. The skinfold chamber is a feasible and versatile model for observation of the dynamic process of microvascular response after foreign-body implantation, and offers much perspective.
authors.affiliation: Department of Orthopaedic Surgery, Rheinische Friedrich-Wilhelms-University, D-53105 Bonn, Germany. umcb01@uni-bonn.de
authors.forename: C N
authors.initials: CN
authors.lastname: Kraft
authors.forename: B
authors.initials: B
authors.lastname: Burian
authors.forename: O
authors.initials: O
authors.lastname: Diedrich
authors.forename: M A
authors.initials: MA
authors.lastname: Wimmer