[Histopathological findings in cytomegalovirus retinitis].
OBJECTIVE
We examined eyeballs collected from autopsied acquired immunodeficiency syndrome patients with cytomegalovirus (CMV) retinitis, and analyzed the precise pathogenesis of CMV retinitis.


METHODS
Eyeballs were fixed with 10% buffered formalin embedded in paraffin. CMV antigens were investigated by histopathological and immunohistochemical analyses. Histopathological findings were compared with funduscopic images.


RESULTS
CMV antigens remained in the necrotic area of the retina and many CMV immediate early antigens existed in intact parts of the inner retina showing almost intact structure, and around retinal vessels.


CONCLUSIONS
The results suggest that CMV infects the inner retina first via the retinal vessels, although funduscopic examination may appear normal. It extends through the neuronal cells and glial cells horizontally and Muller cells vertically. CMV severely damages the retinal structure.
Kashiwase
Mitsutoshi
M
Department of Ophthalmology, Tokyo Medical University, Japan.
Yamauchi
Yasuyuki
Y
Sata
Tetsutaro
T
Nagata
Yoichi
Y
Usui
Norio
N
Mochizuki
Manabu
M
Fujino
Yujiro
Y
Iwasaki
Takuya
T
Sato
Yuko
Y
Kurata
Takeshi
T
Usui
Masahiko
M
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology* / Q000821:virology; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology; D017726:Cytomegalovirus Retinitis / Q000473:pathology* / Q000821:virology; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology* / Q000821:virology; D013194:Staining and Labeling
D000956:Antigens, Viral; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin