title: Dupuytren's disease risk factors.
abstract: Dupuytren's is a common problem, but little is known about its aetiology. We have undertaken a large case-control study to assess and quantify the relative contributions of diabetes and epilepsy as risk factors for Dupuytren's in the community. Cases were patients with a diagnosis of Dupuytren's disease and, for each, two controls were individually matched by age, sex, and general practice. Our dataset included 821 cases and 1,642 controls. Five hundred and eighty-eight (72%) of the cases were men. The mean age at diagnosis was 62 (range 24-97) years. Diabetes was a significant risk factor for Dupuytren's disease (OR=1.75) and there was an increased risk for medicinally treated diabetes (metformin--OR=3.56; sulphonylureas--OR=1.75) and particularly insulin controlled (OR=4.38) rather than diet-controlled diabetes. Epilepsy (OR=1.12) and anti-epileptic medications were not associated with Dupuytren's disease. Ascertainment bias in previous studies may explain the reported association with epilepsy.
authors.affiliation: Department of Trauma and Orthopaedics, Derbyshire Royal Infirmary, UK. john.geoghegan@ntlworld.com
authors.forename: J M
authors.initials: JM
authors.lastname: Geoghegan
authors.forename: J
authors.initials: J
authors.lastname: Forbes
authors.forename: D I
authors.initials: DI
authors.lastname: Clark
authors.forename: C
authors.initials: C
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Hubbard
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D019992:Databases as Topic; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000453:epidemiology; D004387:Dupuytren Contracture / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D009819:Office Visits / Q000706:statistics & numerical data; D012307:Risk Factors; D013453:Sulfonylurea Compounds / Q000627:therapeutic use; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; D008687:Metformin