Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literature.
BACKGROUND
Metastatic cancer to the vulva is a rare diagnosis and is estimated to account for 5-8% of all vulvar cancers.


METHODS
A 57-year-old postmenopausal woman was referred for the evaluation of a new vulvar mass. CT scan of the pelvis demonstrated a 4 x 6 cm lobular mass of the left labia. An outpatient excisional biopsy revealed a poorly differentiated large cell carcinoma with prominent necrosis and focal perineural invasion consistent with a bronchogenic carcinoma. A subsequent PET scan of the chest revealed a large primary lung carcinoma confirmed by CT-guided biopsy that was identical to the vulvar tumor.


CONCLUSIONS
This case represents the only literature described primary lung carcinoma presenting as a vulvar metastasis.
Rocconi
Rodney P
RP
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233, USA. rocconi@uab.edu
Leath
Charles A
CA
Johnson
William M
WM
Barnes
Mack N
MN
Conner
Michael G
MG
D018287:Carcinoma, Large Cell / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000473:pathology / Q000556:secondary*