[Phenotypes of smooth muscle cells in carotid arteries in Takayasu's disease].
The phenotype of smooth-muscle cells (SMC) of carotid arteries in health and Takayasu's disease were studied using immunofluorescence. In contrast to unaffected carotid artery, medial SMC were represented by heterogenic cell population. Many SMC in this disease expressed fibronectin with ED-A sequence, contained cytokeratin 8 and were deprived of h-caldesmon. Similar phenotypic characteristics are typical for SMC of embryonal phenotype. SMC with this phenotype are observed in the thickened intima of the carotid arteries in Takayasu's disease. It is supposed that SMC precursors in arterial media are activated in this disease, migrate into subendothelial layer and are responsible for the thickening of the intima.
Shekhonin
B V
BV
Tararak
E M
EM
Griaznov
O G
OG
Zotikov
A E
AE
Pokrovskiĭ
A V
AV
D000328:Adult; D002148:Calmodulin-Binding Proteins / Q000096:biosynthesis; D002339:Carotid Arteries / Q000378:metabolism / Q000473:pathology*; D005353:Fibronectins / Q000096:biosynthesis; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007633:Keratins / Q000096:biosynthesis; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology*; D013625:Takayasu Arteritis / Q000378:metabolism / Q000473:pathology*; D017539:Tunica Intima / Q000378:metabolism; D017540:Tunica Media / Q000378:metabolism
D002148:Calmodulin-Binding Proteins; D005353:Fibronectins; D007633:Keratins