title: Discovery of new chemical leads for prostaglandin D2 receptor antagonists.
abstract: A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure-activity relationship data are also presented.
authors.affiliation: Minase Research Institute, Ono Pharmaceutical Co., Ltd, Shimamoto, Mishima, Osaka 618-8585, Japan. torisu@ono.co.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Torisu
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Maki
authors.initials: M
authors.lastname: Iwahashi
authors.forename: Hiromu
authors.initials: H
authors.lastname: Egashira
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Nakai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Okada
authors.forename: Fumio
authors.initials: F
authors.lastname: Nanbu
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ohuchida
authors.forename: Hisao
authors.initials: H
authors.lastname: Nakai
authors.forename: Masaaki
authors.initials: M
authors.lastname: Toda
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D051379:Mice; D011448:Prostaglandin Antagonists / Q000737:chemistry* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D011448:Prostaglandin Antagonists; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C036293:prostaglandin D2 receptor