Analysis of self-assembled monolayers by thermal desorption mass spectrometry: neighborhood interaction and hydrogen/deuterium exchange.
Two ideas for characterizing the local structure in mixed self-assembled monolayers (SAMs) were introduced. First, to use thermal desorption mass spectrometry (TD-MS) to probe nearest neighborhoods in the mixed monolayers. Second, to use hydrogen/deuterium exchange as a probe of the accessibility of acidic protons to exchange. Neighborhood interactions provided an opportunity to observe microscopic phase changes at the SAMs surface as a function of the OH-terminal ratio. H/D exchange between surficial OH-terminal SAMs and D2O was successfully observed. H/D exchange was of importance in characterizing the surface properties and molecular basis interactions for the design of bio-interface structures using self-assembled monolayers.
Shibue
Toshimichi
T
Materials Characterization Central Laboratory, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555, Japan.