Transcription, translation, degradation, and circadian clock.
Synthesis and degradation of mRNA together with synthesis and degradation of corresponding protein, this four-step-expression confers great fitness to all organisms. Transcription rate and mRNA stability both are essential for circadian expression of clock genes. In many cases, transcription rates and half-lives of mRNAs and corresponding proteins are not necessarily tightly linked with each other. The methods for measuring four-step-expression should be carefully selected and the experimental conditions should be strictly controlled.
Shu
Yuan
Y
College of Life Science, Sichuan University, 29 Wang-Jiang Road, Chengdu 610064, PR China.
Hong-Hui
Lin
L
D000818:Animals; D001683:Biological Clocks; D002940:Circadian Rhythm / Q000235:genetics*; D007700:Kinetics; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*
D011506:Proteins; D012333:RNA, Messenger