Relation between pharmacodynamic and anthropometric parameters during ergometry at rest and after repeated intake of metoprolol in healthy volunteers: results of a pilot study.
Metoprolol is a widely used beta1-selective beta-blocker in hypertension and tachycardia. The influence on vital signs at rest and during ergometry (exercise heart rate or blood pressure, effect areas above baseline) was investigated in a pilot study with 18 healthy volunteers (mean age 29.1 years) by means of multiple and pairwise correlation analysis. At rest, the difference between predose and day 5 values were not associated with anthropometric characteristics. During ergometry for weight and height significant negative correlations were found corresponding to marked beta-values in the multiple regression models. Therefore heart rate decreases less markedly in slim persons which should be taken into consideration in exercise tests during metoprolol intake.
Koch
H J
HJ
Department of Gerontopsychiatry, University of Regensburg, Regensburg, Germany. horst.koch@bkr-regensburg.de
Raschka
C
C
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D000328:Adult; D000886:Anthropometry; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000493:pharmacokinetics / Q000494:pharmacology*; D010865:Pilot Projects; D012044:Regression Analysis
D000319:Adrenergic beta-Antagonists; D008790:Metoprolol