[Comparative characteristics of immunological, clinical and morphological features of human lymphoid tumors in respect with tumor genesis and progression].
We describe three lymphoid tumors with the same immunophenotype characteristic for chronic lymphoid leukemia (CD19+/CD5+, clonality of the light immunoglobulin chains, CD23+ and CD10-). However, clinical picture and morphology of neoplastic cells dictate different clinical forms of these cases: chronic lymphoid leukemia, large cell transformation of chronic lymphoid leukemia and diffuse large B-cell lymphoma. Taking into account that immunophenotype reflects the origin of tumor, while clinical outcome and morphological features of cells reflect the stage of tumor progression and/or pathway of tumor formation, we discuss the approach to natural classification of lymphoid tumors based on the process of their evolution.
Gretsov
E M
EM
Churakova
Zh V
ZhV
Sheval'
E V
EV
Vorob'ev
I A
IA
D018941:Antigens, CD19 / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D018956:CD5 Antigens / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology*; D008027:Light; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology*; D015260:Neprilysin / Q000276:immunology; D017455:Receptors, IgE / Q000276:immunology; D012542:Scattering, Radiation; D013154:Spleen / Q000276:immunology / Q000473:pathology*
D018941:Antigens, CD19; D018956:CD5 Antigens; D017455:Receptors, IgE; D015260:Neprilysin