title: Analysis of the time interval between diagnoses in women with double primary breast and ovarian or primary peritoneal cancers.
abstract: OBJECTIVE
  The time interval between diagnoses of breast and epithelial ovarian cancer is not well established in women with dual primary tumors of both organ sites. Our goals were to examine the time interval between diagnoses and identify any relationship to clinicopathologic factors.
  
  
  METHODS
  We identified 49 patients who developed both cancers. These patients were divided into two groups: group 1 patients developed breast cancer first, group 2 patients had ovarian before breast cancer. The risk of a BRCA1 or BRCA2 mutation in our study subjects was estimated using the BRCAPRO. Parameters were compared using either the chi(2) or the Kruskal-Wallace test.
  
  
  RESULTS
  There were 26 and 23 patients in groups 1 and 2, respectively. The mean time interval was longer in group 2 (86 vs. 45 months; P = 0.013). Median PFS and OS were longer in group 2 for both cancers [PFS: 161 vs. 61 months for breast (P = 0.85) and 132 vs. 39 months for ovarian (P = 0.019); OS: 250 vs. 115 months for breast (P = 0.77) and 277 vs. 42 months for ovarian (P = 0.0013)]. OS was longer in group 2 for both cancers combined 217 vs. 115 (P = 0.026). The estimated risk of BRCA mutation was at least 20% in the majority of the patents.
  
  
  CONCLUSIONS
  Our data indicates that the time interval between the diagnosis of breast and ovarian carcinomas is 4 years. In contrast, the time interval between the diagnosis of ovarian and breast carcinomas is 7 years. These results could be useful in counseling women at risk.
authors.affiliation: Department of Obstetrics and Gynecology, State University of New York at Buffalo, Buffalo, NY 14222, United States.
authors.forename: Alexander
authors.initials: A
authors.lastname: Olawaiye
authors.forename: Lori
authors.initials: L
authors.lastname: Caesar
authors.forename: Debra
authors.initials: D
authors.lastname: Walsh
authors.forename: Mollie
authors.initials: M
authors.lastname: Lyman
authors.forename: John
authors.initials: J
authors.lastname: Yeh
authors.forename: Kerry
authors.initials: K
authors.lastname: Rodabaugh
authors.forename: David
authors.initials: D
authors.lastname: Marchetti
authors.forename: Shashikant
authors.initials: S
authors.lastname: Lele
authors.forename: Kunle
authors.initials: K
authors.lastname: Odunsi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012189:Retrospective Studies; D013997:Time Factors