title: Development of caries in permanent first molars adjacent to primary second molars with interproximal caries: four-year prospective radiographic study.
abstract: OBJECTIVE
  This study investigated the effect of the primary second molars' distal surface caries on the incidence of the permanent first molars' mesial surface caries in 613 paired tooth surfaces of children ages 6 to 8 years at baseline examination.
  
  
  METHODS
  Proximal caries and its progression were diagnosed by bite-wing radiographs taken at a 1-year interval over a period of 4 years. The permanent first molars' mesial surfaces and primary second molars' distal surfaces were examined. Recorded were: (1) sound surfaces; (2) carious lesions on the enamel's external and internal half and on the dentin's external, middle, and internal third; (3) filled, extracted, and exfoliated teeth. The logistic model for panel data was employed to estimate the effect of proximal caries of the primary second molars' distal surfaces on the incidence of the permanent first molars' mesial surface caries. The 95% confidence interval probability was used. Sensitivity and specificity as well as the positive and negative predictive rates were computed.
  
  
  RESULTS
  The results showed that the presence of proximal caries on each primary second molars' distal surfaces significantly affected the development of proximal caries on the corresponding permanent first molar's mesial surfaces. Age was estimated to exert a positive and highly significant impact, while gender had no effect. The odds ratio values ranged from 4.86 to 63.43. The values of sensitivity and specificity ranged from 45% to 97% and 80% to 89%, respectively, while the positive and negative rates ranged from 40% to 56% and 90% to 99%, respectively.
  
  
  CONCLUSIONS
  Proximal caries present on the primary second molars' distal surfaces increases the risk of developing caries on the permanent first molars' mesial surfaces. This risk, however, is different among the paired surfaces studied.
authors.affiliation: Department of Pediatric Dentistry, School of Dental Medicine, University of Athens, Athens, Greece. avanderas@dent.uoa.gr
authors.forename: Apostole P
authors.initials: AP
authors.lastname: Vanderas
authors.forename: Katerina
authors.initials: K
authors.lastname: Kavvadia
authors.forename: Lisa
authors.initials: L
authors.lastname: Papagiannoulis
mesh_terms: D000367:Age Factors; D002648:Child; D003731:Dental Caries / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003733:Dental Caries Susceptibility; D003818:Dentition, Mixed; D018450:Disease Progression; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008963:Molar / Q000000981:diagnostic imaging / Q000473:pathology; D016017:Odds Ratio; D011446:Prospective Studies; D011859:Radiography