[Functional-behavioral profile of new cyclic GABA analogs in acute toxicity tests].
The properties of karphedone and phepyrone--new phenyl derivatives of pyrrolidone possessing nootropic activity--were studied in the course of the acute toxicity tests on rats. The drug effects were evaluated in terms of their integral influence on the state and behavior of test animals. The real therapeutic range and the profit/risk ratio of karphedone were comparable with those of the reference drug pyracetam and exceeded by a factor of 1.3 the corresponding values for phepyrone (irrespective of the LD50 values). The results give grounds for the further preclinical investigation of karphedone.
Bugaeva
L I
LI
Spasov
A A
AA
Verovskiĭ
V E
VE
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002219:Carbamates / Q000494:pharmacology / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology / Q000633:toxicity*; D010889:Piracetam / Q000494:pharmacology / Q000633:toxicity; D011760:Pyrrolidinones / Q000494:pharmacology / Q000633:toxicity*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity*
C493152:1-carbamoyl-4-phenylpyrrolidone-2; D002219:Carbamates; D018697:Nootropic Agents; D011760:Pyrrolidinones; D005680:gamma-Aminobutyric Acid; C029565:fepiron; D010889:Piracetam