Granular cell tumor of the breast preoperatively diagnosed by fine-needle aspiration cytology: report of a case.
Granular cell tumors (GCTs) have a characteristic cytological appearance, and fine-needle aspiration cytology (FNAC) has been suggested to be the diagnostic modality of choice. However, the differential diagnosis has not yet been well described. We herein describe a rare case of GCT of the breast and discuss the differential diagnosis. A 53-year-old woman presented to our hospital with a left breast mass. In clinical and radiological examinations, the mass was suspected to be malignant. Cytologically, the tumor was composed of cohesive groups of cells with a syncytial appearance, and the cells contained abundant, finely eosinophilic cytoplasmic granules and small round-to-slightly-oval nuclei, thus suggesting the presence of benign GCT. The results of immunohistochemical staining supported the proposed deviation from Schwann cells. This case emphasizes the fact that GCTs are a rare but important possibility in the differential diagnosis of breast tumors, and that FNAC may provide clinically useful information on the management of such lesions.
Akatsu
Tomotaka
T
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Kobayashi
Hideyuki
H
Uematsu
Shigeto
S
Tamagawa
Eiji
E
Shinozaki
Hiroharu
H
Kase
Kenichi
K
Kobayashi
Kenji
K
Otsuka
Shujiro
S
Mukai
Makio
M
Kitajima
Masaki
M
D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D016586:Granular Cell Tumor / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011300:Preoperative Care