[Role of ICAM-1 in eosinophilia and prognosis of nasal polyps].
OBJECTIVE
To investigate the role of adhesion molecule ICAM-1 (Intercellular adhesion molecule-1) in eosinophilia and prognosis of nasal polyps.


METHODS
Expression of ICAM-1 were detected and quantified in 35 cases of nasal polyps with fluorescence-immunohistochemistry analysis and its relationships to eosinophilia and prognosis of nasal polyps were evaluated.


RESULTS
The numbers of eosinophils in nasal polyps and control nasal mucosas were 28.4 +/- 10.7/mm2 and 9.9 +/- 8.6/mm2, and fluorescent densities of ICAM-1 were 115.9 +/- 82.4 and 28.2 +/- 17.1. The expression of ICAM-1 was associated with the heaviness of nasal polyps.


CONCLUSIONS
ICAM-1 may play an important role in the formation and prognosis of nasal polyps.
Zhou
Bing
B
Department of Otolaryngology-Head and Neck Surgery, Capital University of Medical Sciences Affiliated Beijing Tongren Hospital,Beijing Institute of Otolaryngology, Beijing, 100005, China.
Li
Huabin
H
Han
Demin
D
Liu
Zhongyan
Z
D000328:Adult; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis
D018799:Intercellular Adhesion Molecule-1