title: Design, synthesis, and biochemical evaluation of novel alpha V beta 3 integrin ligands.
abstract: Studies on integrin alphaVbeta3 have implicated this receptor in a number of pathologies. In this article we describe some of our initial efforts to design small molecules alphaVbeta3 ligands incorporating an indole core template and an oxyguanidine as basic ending. Synthesis, biochemical activity and pharmacological properties are analyzed.
authors.affiliation: 3-Dimensional Pharmaceuticals, Inc, Eagleview Corporate Center, 665 Stockton Drive, Suite 104, Exton, PA 19341, USA. jmaruga1@prdus.jnj.com
authors.forename: Juan Jose
authors.initials: JJ
authors.lastname: Marugan
authors.forename: Kristin D
authors.initials: KD
authors.lastname: Haslow
authors.forename: Carl
authors.initials: C
authors.lastname: Crysler
mesh_terms: D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D039302:Integrin alphaVbeta3 / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands
chemical_list: D039302:Integrin alphaVbeta3; D008024:Ligands