[Analysis of serological findings and clinical manifestations of TORCH infections in newborns].
BACKGROUND
To search for the serological findings and early clinical manifestations as evidences for prevention and treatment TORCH infections in pregnant women and newborns as early as possible.


METHODS
ELASA was performed to screen specific anti-TORCH (Toxoplasma gondii, Cytomegalovirus, Rubella virus, Herpes simplex virus) Ig-M antibodies.


RESULTS
Totally 1,554 in-patients who were treated in Neonatal Intensive Care Unit (NICU) of our hospital from January 2000 to January 2003 were retrospectively studied, 48 of them had TORCH infections. Cytomegalovirus (CMV), rubella and herpes simplex virus infections accounted for 52.1%, 33.3% and 14.6%, respectively. None of them had toxoplasma infection.


CONCLUSIONS
TORCH infections can cause multiorgan lesions, such as hearing impairment, hyperbilirubinemias and liver dysfunction, impairment of neurologic system, myocardial impairment, thrombocytopenia, and congenital heart disease.Rubella vaccine inoculation, serological screening during pregnancy and early period of newborn, intervention and treatment in the early period are most important.
Wang
Lei
L
ICU, Beijing Childrens Hospital Affiliated to Capital University of Medical Sciences, Beijing 100045, China.
Li
Ke-hua
KH
Liu
Hong
H
Liu
Jing-yuan
JY
Li
Yun-juan
YJ
D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology* / Q000821:virology; D008297:Male; D015997:Neonatal Screening; D012189:Retrospective Studies; D012409:Rubella / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology*
D000914:Antibodies, Viral