title: [Non-erosive GERD].
abstract: Non-erosive reflux disease (NERD) is defined as those who have typical reflux symptoms without evidence of erosive changes in their lower esophageal mucosa. Symptoms should occur more than twice a week, and esophageal mucosa should be free from erosion. However, the differentiation from normal might be difficult because of the ambiguous definition. Pathophysiological mechanism on heartburn is not simply acidic stimuli to esophageal mucosa, but also esophageal distention, hypersensitive esophagus and/or exaggerate perception. NERD is not a simply milder form of reflux disease, because they have poor response to pharmacotherapy. Based on such evidence, newer concept for NERD is required.
authors.affiliation: Department of Comprehensive Medicine, Tohoku University Hospital.
authors.forename: Michio
authors.initials: M
authors.lastname: Hongo
authors.forename: Daisaku
authors.initials: D
authors.lastname: Tamura
mesh_terms: D004791:Enzyme Inhibitors / Q000627:therapeutic use; D004947:Esophagus / Q000473:pathology / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000145:classification / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D006356:Heartburn / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008019:Life Style; D008991:Monitoring, Physiologic; D054328:Proton Pump Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors