Epithelial stem cells: stepping out of their niche.
In this issue of Cell, have shown that two subpopulations of cells exist within the hair follicle stem cell niche. Despite being partially differentiated, clonal populations of suprabasal bulge region cells can regenerate skin and hair follicles as well as a new stem cell niche. The findings suggest that early lineage commitments of epithelial cells in the hair follicle may be reversible.
Christiano
Angela M
AM
Departments of Dermatology and Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology; D000078404:Epidermal Cells; D004817:Epidermis / Q000254:growth & development; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology*; D018859:Hair Follicle / Q000166:cytology / Q000254:growth & development*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*