Visualization of large-scale correlations in gene expressions.
Large-scale expression data are today measured for several thousands of genes simultaneously. Furthermore, most genes are being categorized according to their properties. This development has been followed by an exploration of theoretical tools to integrate these diverse data types. A key problem is the large noise-level in the data. Here, we investigate ways to extract the remaining signals within these noisy data sets. We find large-scale correlations within data from Saccharomyces cerevisiae with respect to properties of the encoded proteins. These correlations are visualized in a way that is robust to the underlying noise in the measurement of the individual gene expressions. In particular, for S. cerevisiae we observe that the proteins corresponding to the 400 highest expressed genes typically are localized to the cytoplasm. These most expressed genes are not essential for cell survival.
Eriksen
Kasper Astrup
KA
Nordita, Blegdamsvej 17, 2100, Copenhagen, Denmark.
Hörnquist
Michael
M
Sneppen
Kim
K
D002467:Cell Nucleus / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics*