Bilateral globus pallidus internus deep brain stimulation therapy for primary generalized dystonia.
Primary generalized dystonia (PGD) associated with the early-onset generalized dystonia gene (DYT1) can cause severe disability, compromising an individual's ability to perform activities of daily living. Pharmacological treatment has been inadequate in alleviating the motor dysfunctions. Deep brain stimulation of the bilateral globus pallidus internus (DBS B-GPi) has been documented to reduce these debilitating motor abnormalities. This report details the successful treatment of a DYT1-positive 13 year-old boy suffering from PGD.
Padaliya
Bimal B
BB
Vanderbilt University School of Medicine, USA.
Davis
Thomas L
TL
Newman
William J
WJ
Konrad
Peter E
PE
Covington
Cassondra D
CD
Gill
Chandler E
CE
Abramovitch
Anna I
AI
Charles
P David
PD
D001905:Botulinum Toxins / Q000627:therapeutic use; D002648:Child; D046690:Deep Brain Stimulation / Q000379:methods*; D003975:Diazepam / Q000627:therapeutic use; D004421:Dystonia / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D016896:Treatment Outcome
D001905:Botulinum Toxins; D003975:Diazepam; D008691:Methadone