[Influence of Shenqi Recipe on mesangial cells and interstitial fibroblasts of chronic renal failure rats].
OBJECTIVE
To observe the effect of Shenqi Recipe on the proliferation of glomerular mesangial cells (MC) and interstitial fibroblasts (FC) in rats.


METHODS
The effect of serum containing prepared drugs from normal and chronic renal failure rats treated by Shenqi Recipe on glomerular mesangial cells and intersititial fibroblasts in vitro was observed by MTT colorimetric assay and serophrmacology.


RESULTS
Compared with the blank sample normal rats, serum containing Shenqi Recipe inhibited the proliferation of MC and FC (P<0.001), and the serum containing Shenqi Recipe of CRF rats had significantly inhibited the proliferation of MC and FC compared with the model group(P<0.001). Conclusion Shenqi Recipe can postpone CRF progress by this mechanism.
Mu
Jing
J
Research Center of Pharmacology and Toxicology of New Chinese Drugs, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Li
Yi-Kui
YK
Fu
Sheng-Guang
SG
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005920:Glomerular Mesangium / Q000166:cytology / Q000187:drug effects*; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal