Chronic toxicity of Gynostemma pentaphyllum.
The effect of water extract of Gynostemma pentaphyllum was evaluated on 6-month chronic toxicity in Wistar rats. Control group received orally 10 ml kg(-1) day(-1). The extract was orally given to the five treatment groups at the doses of 6, 30, 150, 750 and 750 mg kg(-1) day(-1) for 24 weeks. The last group served as the recovery group. The results showed that the extract did not produce any significant dose-related changes. Therefore, it is concluded that the extract of G. pentaphyllum at the given doses did not produce any significant toxic effect in rats during 6-month period of the treatment.
Attawish
A
A
Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health, 88/7 Tiwanont road, Muang, Nonthaburi 11000, Thailand.
Chivapat
S
S
Phadungpat
S
S
Bansiddhi
J
J
Techadamrongsin
Y
Y
Mitrijit
O
O
Chaorai
B
B
Chavalittumrong
P
P
D000284:Administration, Oral; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D029774:Gynostemma; D008297:Male; D009929:Organ Size; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts