Estimating the correlation of pairwise relatedness along chromosomes.
The 'spatial' pattern of the correlation of pairwise relatedness among loci within a chromosome is an important aspect for an insight into genomic evolution in natural populations. In this article, a statistical genetic method is presented for estimating the correlation of pairwise relatedness among linked loci. The probabilities of identity-in-state (IIS) are related to the probabilities of identity-by-descent (IBS) for the two- and three-loci cases. By decomposing the joint probabilities of two- or three-loci IBD, the probability of pairwise relatedness at a single locus and its correlation among linked loci can be simultaneously estimated. To provide effective statistical methods for estimation, weighted least square (LS) and maximum likelihood (ML) methods are evaluated through extensive Monte Carlo simulations. Results show that the ML method gives a better performance than the weighted LS method with haploid genotypic data. However, there are no significant differences between the two methods when two- or three-loci diploid genotypic data are employed. Compared with the optimal size for haploid genotypic data, a smaller optimal sample size is predicted with diploid genotypic data.
Hu
X-S
XS
Department of Forest Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4. xin-sheng.hu@ualberta.ca
D000818:Animals; D002875:Chromosomes; D004171:Diploidy; D019143:Evolution, Molecular; D008040:Genetic Linkage; D005838:Genotype; D006238:Haploidy; D006801:Humans; D008957:Models, Genetic; D009010:Monte Carlo Method; D040641:Quantitative Trait Loci