[Ethnic differences in apolipoprotein B levels in hyperlipidemia in Russian and Kirghiz populations].
OBJECTIVE
To evaluate the levels of apolipoprotein B (apo-B) and coronary heart disease (CHD) risk factors in Russians and the Kirghiz with primary hyperlipidemia (PHL).


METHODS
Lipid spectrum of the blood (LDLP and HDLP cholesterol, total cholesterol, triglycerides), apo-B, CHD risk factors were studied in 60 Russian and 75 Kirghis patients with PHL aged 28 to 67 years (mean age 50.0 +/- 7.59 years, 56 females and 79 males).


RESULTS
In Russians a mean level of LDLP cholesterol and apo-B was significantly higher than in Kirghiz patients (3.95 +/- 1.29 mmol/l vs 3.51 +/- 1.17 mmol/l, p = 0.042; 173.3 +/- 57.3 mg/dl vs 145.5 +/- 49.3 mg/dl, p = 0.003, respectively). CHD in both ethnic groups occurred with similar rates. The multifactorial regression analysis shows that an apo-B concentration can serve an independent risk factor associated with CHD in the Kirghiz population (beta = 0.25, p = 0.03) while in Russians living in Kirghizia this factor is a low content of HDLP cholesterol (beta = -0.25, p = 0.05).
Mirrakhimov
E M
EM
Noruzbaeva
A M
AM
Lunegova
O S
OS
Afanas'eva
M I
MI
Adamova
I Iu
IIu
Pokrovskiĭ
S N
SN
Poroshchaĭ
E N
EN
Mirrakhimov
M M
MM
D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000208:ethnology* / Q000209:etiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000208:ethnology*; D007707:Kyrgyzstan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D012426:Russia / Q000208:ethnology
D001055:Apolipoproteins B