title: Long-term survival achieved by repeated resections of metachronous pulmonary and adrenal metastases of alpha-fetoprotein-producing gastric cancer: report of a case.
abstract: We report a case of long-term survival achieved by repeated resections of metastases from alpha-fetoprotein (AFP)-producing gastric cancer. A 59-year-old man initially underwent total gastrectomy with lymph node dissection and resection of the spleen and left adrenal gland, for an advanced AFP-producing gastric cancer. A solitary pulmonary metastasis was resected 2 years later, and then a right adrenal gland metastasis, an inferior vena cava thrombus, and another pulmonary metastasis were resected 6 months, 1 year, and 8 months after each other, respectively. Thus, the patient has survived for 7 years and no further evidence of disease was found at his last follow-up examination. To the best of our knowledge, this is the first case of AFP-producing gastric cancer resulting in metachronous solitary pulmonary and adrenal gland metastases, but not liver metastasis. We report this case to show that for selected cases, surgical resection of these metastases is feasible and may extend survival.
authors.affiliation: Department of Surgical Oncology, National Cancer Center Hospital East, Chiba, Japan.
authors.forename: Chigusa
authors.initials: C
authors.lastname: Nakahashi
authors.forename: Taira
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Masaru
authors.initials: M
authors.lastname: Konishi
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakagohri
authors.forename: Kazuto
authors.initials: K
authors.lastname: Inoue
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Oda
authors.forename: Junji
authors.initials: J
authors.lastname: Yoshida
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hasebe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ochiai
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000556:secondary* / Q000601:surgery*; D005743:Gastrectomy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D013534:Survival; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins