Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice.
We measured preprocortistatin mRNA expression in young and aged transgenic (Tg) mice overexpressing the human beta-amyloid precursor protein (hbetaAPP) under the platelet-derived growth factor-beta promoter. Our findings suggest that the significant increase in hippocampal cortistatin mRNA expression during normal aging is significantly attenuated in Tg mice at an age known to exhibit beta-amyloid protein (Abeta) deposition. These deficits in cortistatin expression may play a role in the deficits in hippocampal-dependent spatial learning and sleep/wake states previously demonstrated in aged Tg mice.
Winsky-Sommerer
Raphaëlle
R
Department of Molecular Biology, The Scripps Research Institute, La Jolla , CA 92037, USA.
Spier
Avron D
AD
Fabre
Véronique
V
de Lecea
Luis
L
Criado
José R
JR
D000375:Aging / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology; D000818:Animals; D015536:Down-Regulation / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008822:Mice, Transgenic; D009479:Neuropeptides / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011498:Protein Precursors / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000096:biosynthesis / Q000235:genetics
D016564:Amyloid beta-Protein Precursor; D009479:Neuropeptides; D011498:Protein Precursors; D012333:RNA, Messenger; C099323:cortistatin; C107518:preprocortistatin; D020797:Receptor, Platelet-Derived Growth Factor beta