title: Genomic relationship of Salmonella enterica serovar typhimurium DT104 isolates from Korea and the United States.
abstract: Salmonella enterica serovar Typhimurium DT104 (Salmonella Typhimurium DT104 or DT104) has been emerging as a common pathogen for human in Korea since 1997. In order to compare the genomic relationship and to search for the dominant strains in Korea, we conducted pulsed-field gel electrophoresis (PFGE) and IS200 fingerprinting of 25 epidemiological unrelated isolates from human and animals from Korea and cattle from America. Two Salmonella Typhimurium DT104 isolates from human in Korea and all 8 isolates from American cattle had indistinguishable patterns from the PFGE and IS200 fingerprinting but multidrug-resistant Salmonella Typhimurium isolates, including DT104, from Korean animals had diverse genetic patterns. The data suggest that a dominant DT104 strain might have circulated between Korean and American cattle and that it had a high level of clonality.
authors.affiliation: Laboratory of Enteric Infections, Department of Microbiology, National Institute of Health, Nokbun-dong 5, Seoul 122-701, Korea.
authors.forename: Shukho
authors.initials: S
authors.lastname: Kim
authors.forename: Sung Guen
authors.initials: SG
authors.lastname: Chun
authors.forename: Ok Young
authors.initials: OY
authors.lastname: Lim
authors.forename: Mi Sun
authors.initials: MS
authors.lastname: Park
authors.forename: Yeon Ho
authors.initials: YH
authors.lastname: Kang
authors.forename: Yong Ho
authors.initials: YH
authors.lastname: Park
authors.forename: Bok Kwon
authors.initials: BK
authors.lastname: Lee
mesh_terms: D000818:Animals; D002417:Cattle; D016000:Cluster Analysis; D016172:DNA Fingerprinting; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000032:analysis* / Q000302:isolation & purification / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D014644:Genetic Variation; D016680:Genome, Bacterial; D006801:Humans; D007723:Korea / Q000453:epidemiology; D017720:Molecular Epidemiology; D012150:Polymorphism, Restriction Fragment Length; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000453:epidemiology / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D014481:United States / Q000453:epidemiology
chemical_list: D004251:DNA Transposable Elements; D004269:DNA, Bacterial; C025580:endodeoxyribonuclease XBAI; D015252:Deoxyribonucleases, Type II Site-Specific