title: Trichothecenes: reference materials and method validation.
abstract: The frequent contamination of food and feed with trichothecene mycotoxins, the high consumption of these products, and the potential risk associated herewith, has led to an increasing public awareness and therefore to the establishment of measures to control trichothecene contamination. The analytical difficulty and the economic importance of controlling trichothecenes in food and feed support the need for certified reference materials (CRMs) and validated methods. They form invaluable tools to ensure comparability and traceability in analytical measurements and are very useful for the implementation of written standards, legislation/regulations and laboratory accreditation. The present paper provides an overview of previous work, current strategies and prospectives for the production of CRMs and validation of analytical methods in the field of trichothecene analysis. Additional information is given on methodological demands, normative frameworks and commonly accepted procedures.
authors.affiliation: Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), European Commission, Retieseweg 111, B-2440 Geel, Belgium. ralf.josephs@cec.eu.int
authors.forename: R D
authors.initials: RD
authors.lastname: Josephs
authors.forename: M
authors.initials: M
authors.lastname: Derbyshire
authors.forename: J
authors.initials: J
authors.lastname: Stroka
authors.forename: H
authors.initials: H
authors.lastname: Emons
authors.forename: E
authors.initials: E
authors.lastname: Anklam
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000592:standards*; D002849:Chromatography, Gas / Q000592:standards; D002851:Chromatography, High Pressure Liquid / Q000592:standards; D002855:Chromatography, Thin Layer / Q000592:standards; D002523:Edible Grain / Q000737:chemistry; D005506:Food Contamination / Q000032:analysis*; D012015:Reference Standards; D015203:Reproducibility of Results; D014255:Trichothecenes / Q000032:analysis*
chemical_list: D014255:Trichothecenes