Primary adrenal insufficiency in patients with acquired immunodeficiency syndrome: report of four cases.
Adrenal insufficiency, though rare, is a well-known complication of acquired immunodeficiency syndrome (AIDS). Over the past 9 years at the National Taiwan University Hospital, 4 patients were diagnosed with primary adrenal insufficiency among 854 non-hemophiliac patients with human immunodeficiency virus infection, with an incidence of 0.19 per 100 patient-years (95% confidence interval, 0.17-0.21 per 100 patient-years). All of the 4 patients were severely immunosuppressed and had been diagnosed with at least 1 AIDS-defining opportunistic illness ever reported to produce adrenal insufficiency in AIDS patients. In 1 of the patients, fluconazole was considered contributory to the development of adrenal insufficiency after treatment at a daily dose of 800 mg for 68 days.
Huang
Yi-Wen
YW
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Chang
Ching-Chung
CC
Sun
Hsin-Yun
HY
Chen
Mao-Yuan
MY
Hung
Chien-Ching
CC
Chang
Shan-Chwen
SC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000309:Adrenal Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects; D015725:Fluconazole / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013624:Taiwan
D000935:Antifungal Agents; D015725:Fluconazole