Synthesis and evaluation of novel oxazoline MMP inhibitors.
MMP inhibitors with novel oxazoline zinc binding groups have been synthesized and evaluated. Selectivity for the inhibition of MMP-9 over MMP-1, MMP-2, and MMP-12 has been achieved in several cases.
Cook
Gregory R
GR
Center for Protease Research, Department of Chemistry, Biochemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105, USA. gregory.cook@ndsu.nodak.edu
Manivannan
Ethirajan
E
Underdahl
Thane
T
Lukacova
Viera
V
Zhang
Yufen
Y
Balaz
Stefan
S
D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D061965:Matrix Metalloproteinase Inhibitors; D010080:Oxazoles; D011480:Protease Inhibitors; D020782:Matrix Metalloproteinases