title: [Serial pathologic changes in livers of Tree shrews and Macaca assamensises infected with human Hepatitis B virus].
abstract: BACKGROUND
  To serially observe the pathologic changes in livers of tree shrews and macaca assamensises infected with HHBV.
  
  
  METHODS
  10 adult tree shrews and 28 macaca assamensises were inoculated with HBV rich human sera. The liver of the animals were regularly biopsied. The liver samples were examined histopathologically by HE staining. Some samples were stained for HBsAg by immunohistochemistry (IH), and HBV DNA by in situ hybridization (ISH).
  
  
  RESULTS
  HBsAg in 80% of tree shrews infected with HHBV can be detected by IH, HBV DNA in 50% of those can be found by ISH.The positive rates of HBsAg in macaca assamensises' livers were 25% by IH, none HBV DNA was detected.
  
  
  CONCLUSIONS
  The tree shrew model seems to be applicable for the research of human hepatitis B.
authors.affiliation: Guangxi Center for Diseases Prevention and Control, Nanning 530021, China.
authors.forename: Shu-sheng
authors.initials: SS
authors.lastname: Wang
authors.forename: Jian-jia
authors.initials: JJ
authors.lastname: Su
authors.forename: Bai-fang
authors.initials: BF
authors.lastname: Feng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Liu-liang
authors.initials: LL
authors.lastname: Qin
authors.forename: Guo-yong
authors.initials: GY
authors.lastname: Huang
authors.forename: Jian-en
authors.initials: JE
authors.lastname: Gao
authors.forename: Xian-min
authors.initials: XM
authors.lastname: Ge
authors.forename: He-min
authors.initials: HM
authors.lastname: Li
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000473:pathology* / Q000821:virology; D006515:Hepatitis B virus / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000821:virology*; D008251:Macaca; D008297:Male; D014418:Tupaiidae
chemical_list: D000914:Antibodies, Viral