Nicorandil associated anal ulceration.
OBJECTIVE
Nicorandil is a vasodilator used to control angina. It has been associated with oral and anal ulceration that resolves upon withdrawal of the drug.


METHODS
We report a series of 13 patients with nonspecific anal ulceration all of whom were receiving nicorandil for control of symptoms of ischaemic heart disease.


RESULTS
All the ulcers had similar clinical and histological appearances. All the ulcers healed on withdrawal of the drug.


CONCLUSIONS
Nicorandil-associated anal ulceration should be considered in the differential diagnoses of nonhealing anal ulcers.
Watson
A
A
Department of Gastroenterology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK. a.j.watson@abdn.ac.uk
Suttie
S
S
Fraser
A
A
O'Kelly
T
T
Loudon
M
M
D000368:Aged; D000787:Angina Pectoris / Q000175:diagnosis / Q000188:drug therapy; D003113:Colonoscopy / Q000379:methods; D005260:Female; D005401:Fissure in Ano / Q000139:chemically induced* / Q000175:diagnosis; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020108:Nicorandil / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D014665:Vasodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use
D014665:Vasodilator Agents; D020108:Nicorandil