title: [Combination chemotherapy with docetaxel+carboplatin in the treatment of cancer of the ovary and fallopian tube].
abstract: Docetaxel and carboplatin were used as adjuvant chemotherapy or maintenance chemotherapy for cancer of the ovary and fallopian tube. Docetaxel 70 mg/m2 and carboplatin (area under the concentration-versus-time curve of 5) were administered intravenously every 3 weeks. Thirty-two patients (median age, 54 years) were assessable. We had objective responses from 5 of 7 (70%) assessable patients. Our toxicity findings included the following: grade 3 or 4 neutropenia (70% of courses); grade 3 or 4 leucocytopenia (35% of courses); hypersensitive reaction (25% of patients, none requiring discontinuation of therapy): edema (30% of patients): peripheral neuropathy (6% of patients). The combination of docetaxel and carboplatin is highly active in cancer of the ovary and follapian tube. The adverse effect was significant neutropenia, but peripheral neuropathy was rare. This regimen represents a reasonable first-line option for patients with ovarian cancer.
authors.affiliation: Dept. of Obstetrics and Gynecology, Juntendo Izunagaoka Hospital.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Furugen
authors.forename: Saori
authors.initials: S
authors.lastname: Nishihara
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kurokawa
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Sone
authors.forename: Naoko
authors.initials: N
authors.lastname: Hata
authors.forename: Akihito
authors.initials: A
authors.lastname: Hata
authors.forename: Yuuko
authors.initials: Y
authors.lastname: Hata
authors.forename: Naoki
authors.initials: N
authors.lastname: Mitsuhashi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D017024:Chemotherapy, Adjuvant; D000077143:Docetaxel; D004334:Drug Administration Schedule; D004487:Edema / Q000139:chemically induced; D005185:Fallopian Tube Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin