title: [Malignant change of laryngeal papilloma in adults].
abstract: OBJECTIVE
  To explore the canceration of laryngeal papilloma in adults, especially its pathological figures, clinical characters and long-term therapeutic efficacy.
  
  
  METHODS
  Among 17 cases of laryngeal papilloma with malignant changes, total laryngectomy and single functional neck dissection were performed for 4 cases (glottis type T3 N1 M0 1, Supraglottic type T4 N0 M0 1, Subglottis type T4 N1 M0 2), partial laryngectomy were performed for other 13 cases. All patients received appropriate radiotherapy whose dose is 45-55 Gy.
  
  
  RESULTS
  Tracheal cannulas of all patients (17 cases) were pull out one year after operation. The rate of extubation is 100%. All patient were follow-up more than 5 years. Among 4 cases of total laryngectomy, one patient died from tumor recurrence 2 years after operation, one patient died from distant metastasis 3 years and 4 months after operation, two patients still alive without tumor 8 years after operation and voicing by using esophagus. Among 13 cases of partial laryngectomy, 12 patients still alive and 1 patient loss follow-up 3 years after operation; 11 patients still alive and 1 patient died from distant metastasis 5 years after operation.
  
  
  CONCLUSIONS
  It is important that repeatedly biopsies to avoid fail to report the malignant change of laryngeal papilloma. The key to cure is complete resection of tumor.
authors.affiliation: Department of Otolaryngology, the Third Affiliated Hospital of Xinxiang Medical College, Henan Province, Xinxiang, 453003, China.
authors.forename: Meiying
authors.initials: M
authors.lastname: Wang
authors.forename: Qingxiao
authors.initials: Q
authors.lastname: Teng
authors.forename: Changyou
authors.initials: C
authors.lastname: Yao
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000473:pathology* / Q000601:surgery