title: [A preliminary report on solid-state fermentation of Ganoderma lucidum with Radix Astragali containing medium].
abstract: OBJECTIVE
  To test the practicability of the solid-state fermentation for medicinal fungi by fermenting Ganoderma lucidum with Radix Astragali containing medium.
  
  
  METHODS
  Ganoderma lucidum was fermented in ordinary medium, drug-containing medium (containing Radix Astragali) and selenium-rich drug-containing medium respectively. The polysaccharide contents of fermentation products from the three kinds of culture media were tested at different time, and the changes were compared.
  
  
  RESULTS
  The polysaccharide contents of fermentation products from the three kinds of culture media were 4.65%, 3.76% and 4.50% respectively and their relative standard deviation were 1.61%, 1.99% and 1.86% respectively. By observing the changes of the contents of polysaccharide, protein and total saponin in fermentation products from the drug-containing medium at different time, it was found that the 28th fermentation day was the time when secondary metabolism was most active, and it should be the fermented terminal point.
  
  
  CONCLUSIONS
  The fermentative combination of Ganoderma lucidum and Radix Astragali is practicable.
authors.affiliation: Institute of Medicinal Fungi & Bio-Technology of Traditional Chinese Medicine, College of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China.
authors.forename: Hua-Zhen
authors.initials: HZ
authors.lastname: Chen
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Chen
mesh_terms: D027885:Astragalus propinquus; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005285:Fermentation / Q000187:drug effects; D005656:Fungal Proteins / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D011134:Polysaccharides / Q000378:metabolism; D020940:Reishi / Q000737:chemistry* / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D005656:Fungal Proteins; D010936:Plant Extracts; D011134:Polysaccharides; C027492:Huang Qi