title: Prevalence of factor XIII Val34Leu polymorphism in patients affected by spontaneous subconjunctival hemorrhage.
abstract: OBJECTIVE
  To verify the prevalence of Val34Leu polymorphism in factor XIII A-chain gene (FXIII Val34Leu) in patients with spontaneous subconjunctival hemorrhage (SCH).
  
  
  METHODS
  Nonrandomized case-control study.
  
  
  METHODS
  One hundred seven white patients suffering from one or more episodes of idiopathic SCH and 107 healthy subjects were matched for age and gender, and genotyped for FXIII Val34Leu. Anamnestic, ophthalmologic, cardiovascular, and serologic examinations were performed.
  
  
  RESULTS
  Frequency of FXIII mutated allele (Leu34) was significantly higher in SCH patients than in controls. Computing together heterozygotes (Val/Leu) and homozygotes (Leu/Leu), genotype distribution was statistically different. In a conditional logistic regression model, the comparison of the three separated genotypes, performed among 25 patients with recurrent idiopathic SCHs and controls, gave significant differences for both Val/Leu and Leu/Leu variables.
  
  
  CONCLUSIONS
  Both homozygosity and heterozygosity for FXIII Val34Leu predispose to idiopathic SCH, emphasizing the role of Leu34 allele as inherited risk factor for spontaneous, especially recurrent, SCHs.
authors.affiliation: Department of Ophthalmology, University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy. f.parmeggiani@tiscali.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Parmeggiani
authors.forename: Ciro
authors.initials: C
authors.lastname: Costagliola
authors.forename: Carlo
authors.initials: C
authors.lastname: Incorvaia
authors.forename: Donato
authors.initials: D
authors.lastname: Gemmati
authors.forename: Sergio
authors.initials: S
authors.lastname: D'Angelo
authors.forename: Silvia
authors.initials: S
authors.lastname: Tognazzo
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Scapoli
authors.forename: Adolfo
authors.initials: A
authors.lastname: Sebastiani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003229:Conjunctival Diseases / Q000235:genetics*; D005130:Eye Hemorrhage / Q000235:genetics*; D005176:Factor XIII / Q000235:genetics*; D005260:Female; D006801:Humans; D007930:Leucine; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D014633:Valine
chemical_list: D005176:Factor XIII; D007930:Leucine; D014633:Valine