title: Apolipoprotein A-I, A-II, and VLDL-B-100 metabolism in men: comparison of a low-fat diet and a high-monounsaturated fatty acid diet.
abstract: The impact of a low-fat diet and a high-MUFA diet on apolipoprotein A-I (apoA-I), apoA-II, and VLDL-apoB-100 metabolism in conditions of unrestricted (ad libitum) energy intake was compared in 65 men randomly assigned to one of two predefined experimental diets. A subsample of 18 men participated in the kinetic study. Before and after the 6-7 week dietary intervention, kinetic subjects received a primed-constant infusion of [5,5,5-2H3]L-leucine for 12 h under feeding conditions. ApoA-I production rate (PR; -31.5%; P <0.001) and fractional catabolic rate (FCR; -24.3%; P <0.05) were significantly decreased after the low-fat diet. These changes in apoA-I PR and FCR with the low-fat diet were also significantly different from those observed with the high-MUFA diet (P <0.01 and P <0.05, respectively). ApoA-II FCR was significantly increased in the high-MUFA group only. No significant within- or between-diet difference was found in VLDL-apoB-100 PR or FCR. These results emphasize the differential impact of the low-fat diet and high-MUFA diet on HDL metabolism.
authors.affiliation: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada.
authors.forename: Sophie
authors.initials: S
authors.lastname: Desroches
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Paradis
authors.forename: Mélanie
authors.initials: M
authors.lastname: Pérusse
authors.forename: W Roodly
authors.initials: WR
authors.lastname: Archer
authors.forename: Jean
authors.initials: J
authors.lastname: Bergeron
authors.forename: Patrick
authors.initials: P
authors.lastname: Couture
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bergeron
authors.forename: Benoît
authors.initials: B
authors.lastname: Lamarche
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000378:metabolism*; D016633:Apolipoprotein A-II / Q000378:metabolism*; D015243:Cholesterol, VLDL / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D015243:Cholesterol, VLDL; D004042:Dietary Fats, Unsaturated