title: Glucose hypometabolism of hypothalamus and thalamus in narcolepsy.
abstract: It has been hypothesized that hypothalamus is involved in narcolepsy. The relative difference between cerebral glucose metabolism of 24 narcoleptic patients and 24 normal controls was studied using 18F-fluorodeoxy glucose positron emission tomography. Patients with narcolepsy showed significantly reduced cerebral glucose metabolism in bilateral rectal and subcallosal gyri, the medial convexity of right superior frontal gyrus, bilateral precuneus, right inferior parietal lobule, and in left supramarginal gyrus (uncorrected p < 0.001). Bilateral posterior hypothalami and mediodorsal thalamic nuclei showed hypometabolism with significance at the level of corrected p < 0.05, with small volume correction. This study showed cerebral glucose hypometabolism of the hypothalamus-thalamus-orbitofrontal pathways in the narcoleptic brain.
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Gangnam-Gu, Seoul, Korea.
authors.forename: Eun Yeon
authors.initials: EY
authors.lastname: Joo
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Tae
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Byung Tae
authors.initials: BT
authors.lastname: Kim
authors.forename: Seung Bong
authors.initials: SB
authors.lastname: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000378:metabolism*; D016011:Normal Distribution; D017286:Polysomnography / Q000379:methods; D013788:Thalamus / Q000378:metabolism*; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D005947:Glucose