title: Nucleus accumbens dopamine receptors in the consolidation of spatial memory.
abstract: Nucleus accumbens dopamine is known to play an important role in motor activity and in behaviours governed by drugs and natural reinforcers, as well as in non-associative forms of learning. At the same time, activation of D1 and D2 dopamine receptors has been suggested to promote intracellular events related to neural plasticity. Therefore, in this study we wished to investigate the role of the two classes of dopamine receptors within the nucleus accumbens on the consolidation of spatial information. On day 1, CD1 male mice were placed in an open field containing five different objects and, immediately after three sessions of habituation, the animals were focally injected within the nucleus accumbens with either the D1 antagonist SCH 23390 (12.5, 25 or 50 ng/side), or the D2 antagonist sulpiride (25, 50, 75 or 100 ng/side). Twenty-four hours later the ability of mice to discriminate an object displacement was assessed. Both the D1 and the D2 antagonists impaired the ability of mice to detect the spatial change. If the highest doses of the two antagonists were injected 2 h after the end of the last of the habituation sessions, no effect was observed in the reactivity to spatial change examined 24 h later. These data demonstrate that activation of both D1 and D2 receptors within the accumbens is necessary in the early stages of the consolidation of spatial information. The data are discussed in terms of involvement of nucleus accumbens dopamine in information processing in the absence of explicit reinforcers.
authors.affiliation: Dipartimento di Genetica e Biologia Molecolare, Università di Roma La Sapienza, Roma, Italy. Andrea.Mele@uniroma1.it
authors.forename: A
authors.initials: A
authors.lastname: Mele
authors.forename: M
authors.initials: M
authors.lastname: Avena
authors.forename: P
authors.initials: P
authors.lastname: Roullet
authors.forename: E
authors.initials: E
authors.lastname: De Leonibus
authors.forename: S
authors.initials: S
authors.lastname: Mandillo
authors.forename: F
authors.initials: F
authors.lastname: Sargolini
authors.forename: R
authors.initials: R
authors.lastname: Coccurello
authors.forename: A
authors.initials: A
authors.lastname: Oliverio
mesh_terms: D000818:Animals; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D005106:Exploratory Behavior; D007858:Learning; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D009473:Neuronal Plasticity; D009714:Nucleus Accumbens / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D013028:Space Perception; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D013469:Sulpiride