Skin diseases and enzymatic antioxidant activity among workers exposed to pesticides.
In this study, 150 workers exposed to pesticides and 50 healthy control subjects were given clinical and dermatological examinations, patch tests, tests of liver and renal function, complete blood count, blood sugar and urinalysis. Activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and glutathione reductase was also evaluated. Dermatological findings were positive in 78%, 76% and 54% of workers exposed to organophosphates, pyrethroids and carbamate pesticides respectively. The patch test was positive in 70% of workers exposed to pyrethroids and 64% exposed to carbamate pesticides. Liver enzyme levels were generally increased in workers while antioxidant enzyme activity was significantly decreased in all workers compared with the controls.
Amer
M
M
Department of Dermatology, Faculty of Medicine, University of Zagazig, Zagazig, Egypt.
Metwalli
M
M
Abu el-Magd
Y
Y
D000328:Adult; D017677:Age Distribution; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D012721:Carbaryl / Q000506:poisoning; D016022:Case-Control Studies; D002617:Chemical Industry; D009783:Dermatitis, Occupational / Q000201:enzymology / Q000453:epidemiology / Q000209:etiology; D003976:Diazinon / Q000506:poisoning; D004534:Egypt / Q000453:epidemiology; D005979:Glutathione Peroxidase / Q000097:blood*; D005980:Glutathione Reductase / Q000097:blood*; D006801:Humans; D007677:Kidney Function Tests; D015227:Lipid Peroxidation; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis / Q000706:statistics & numerical data; D010575:Pesticides / Q000506:poisoning*; D011722:Pyrethrins / Q000506:poisoning; D012869:Skin Absorption; D012882:Skin Tests; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors; D014504:Urban Health / Q000706:statistics & numerical data
D000975:Antioxidants; D010575:Pesticides; D011722:Pyrethrins; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D012721:Carbaryl; D003976:Diazinon