A facile synthesis of C2,N3-disubstituted-4-quinazolone.
A simple and efficient methodology for the synthesis of C(2),N(3)-disubstituted-4 quinazolones from anilines and N-acylanthranilic acids was developed. The new cyclization conditions are much milder than any other reported protocols and resulted in excellent yields (87-98%) without chromatography.
Xue
Song
S
Chemical and Analytical Development, Novartis Institute for Biomedical Research, East Hanover, New Jersey 07936, USA. song.xue@pharma.novartis.com
McKenna
Joseph
J
Shieh
Wen-Chung
WC
Repic
Oljan
O