title: Gene expression profile in experimental mesangial proliferative glomerulonephritis.
abstract: We analyzed gene expression in rat anti-Thy1 antibody-induced glomerulonephritis by using the cDNA microarray method. Ninety-seven genes that differed by more than 1.5-fold intensity in comparison with the controls were selected. Cluster analysis showed that the expression of genes associated with inflammation reached maximum levels at 24 h, while genes involved in the development of fibrosis increased at 7 days after injection. Microarray analysis of animal disease models may be a powerful approach for understanding the gene expression programs that underlie these disorders.
authors.affiliation: Department of Pharmacology, Osaka City University Graduate School of Medical Science, Japan. izumi@msic.med.osaka-cu.ac.jp
authors.forename: Yasukatsu
authors.initials: Y
authors.lastname: Izumi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Izumiya
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shiota
authors.forename: Tokihito
authors.initials: T
authors.lastname: Yukimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shiojima
authors.forename: Masateru
authors.initials: M
authors.lastname: Yamada
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Susumu
authors.initials: S
authors.lastname: Katsuma
authors.forename: Akira
authors.initials: A
authors.lastname: Hirasawa
authors.forename: Gozoh
authors.initials: G
authors.lastname: Tsujimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwao
mesh_terms: D000818:Animals; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods* / Q000706:statistics & numerical data; D015432:Glomerulonephritis, Membranoproliferative / Q000235:genetics* / Q000473:pathology; D046228:Microarray Analysis / Q000379:methods / Q000706:statistics & numerical data; D051381:Rats; D017208:Rats, Wistar