[Influence of single leaf Asarum himalaicum on renal function of rabbits].
OBJECTIVE
To study the influence of single leaf Asarum himalaicum on the renal function of rabbits.


METHODS
Rabbits were divided into three groups. Asarum himalaicum, Asarum heterotropoides and normal saline were intravenously administered to the rabbits of one group respectively. The urine volume per minute, urine pH, urine glucose, protein and red blood cells, BUN, SCr, TXB2, 6-keto-PGF1alpha, TXB2/6-keto-PGF1alpha, endothelin, p-aminohippuric acid clearance rate and phenolsulfonphthalein excretion rate were tested before and after the administration.


RESULTS
A certain dosage of single leaf Asarum himalaicum caused acute renal failure in rabbits. The indices tested were significantly different between rabbits administered Asarum himalaicum and normal saline. As compared with the rabbits administered Asarum heterotropoides, the results of indices tested decreased, but without statistical significance, except for SCr.


CONCLUSIONS
The single leaf Asarum himalaicum can cause renal damage to rabbits. Its renal toxicity is lower that that of Asarum heterotropoides.
Ming
Hai-Xia
HX
Department of Physiology, Gansu College of Traditional Chinese Medicine, Lanzhou, Gansu Province 730000, China. zhh2004222@sina.com
Liu
Jia-Jun
JJ
Huang
Shi-Zuo
SZ
D000818:Animals; D030023:Asarum; D001806:Blood Urea Nitrogen; D016232:Endothelins / Q000652:urine; D005260:Female; D005947:Glucose / Q000032:analysis; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D008297:Male; D010637:Phenolsulfonphthalein / Q000032:analysis; D018515:Plant Leaves / Q000737:chemistry*; D028321:Plant Preparations / Q000494:pharmacology*; D011507:Proteinuria / Q000652:urine; D011817:Rabbits; D011897:Random Allocation; D013045:Species Specificity; D013929:Thromboxane B2 / Q000652:urine
D016232:Endothelins; D028321:Plant Preparations; D013929:Thromboxane B2; D010637:Phenolsulfonphthalein; D005947:Glucose