[Anti-Ku antibodies. Study of prévalence and of clinical meaning].
OBJECTIVE
Auto-immunity against Ku nuclear antigens is rare and clinical meaning remains badly estimated. Our study is for purposes: to appreciate the prévalence of antibodies anti-Ku within the framework of the search for antinuclear antibodies and to clarify clinical and biological relations associated to this auto-immunity.


METHODS
A retrospective study of a series of 10,000 searches for antinuclear antibodies studies the prévalence of the auto-immunity anti-Ku and a retrospective analysis of the data found at the patients bearers of an anti-Ku identifies clinical and biological signs associated with this antibody.


RESULTS
Prévalence anti-Ku is low (1/3493 case of antinuclear antibodies) and association is possible with in a myositic process through variable auto-immune contexts (overlap syndrome) of relative good preview.


CONCLUSIONS
Auto-immunity anti-Ku is so characterized with its weak prévalence, a possible observation during different auto-immune diseases with an obvious frequency of the overlap syndrome often concerning a process myositic. Finally a weak évolutivité seems to characterize the auto-immune diseases of the patients with anti-Ku antibodies.
Beyne-Rauzy
O
O
Service de médecine interne, pavillon des médecines, CHU de Toulouse-Purpan, TSA 40031, 31049 Toulouse cedex 09, France.
Couret
B
B
Fortenfant
F
F
Adoue
D
D
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D034961:Antigens, Nuclear / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D003430:Cross-Sectional Studies; D004268:DNA-Binding Proteins / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000072200:Ku Autoantigen; D008875:Middle Aged; D009220:Myositis / Q000175:diagnosis / Q000276:immunology; D012189:Retrospective Studies; D013577:Syndrome; D013997:Time Factors
D000974:Antibodies, Antinuclear; D034961:Antigens, Nuclear; D001323:Autoantibodies; D004268:DNA-Binding Proteins; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen