title: [Effects of dexamethasone on mucin gene expression in human nasal polyps].
abstract: OBJECTIVE
  To clarify whether glucocorticoid influences mucin 8 gene expression in human nasal polyps.
  
  
  METHODS
  Thirty patients were randomly divided into two groups. The first group were given dexamethasone intravenously before surgery. We make sure the second group of patients didn't receive any kind of glucocorticoid therapy during thirty days before surgery. MUC8 MRNA expression in nasal polyps of each group was detected by reverse transcription polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  The MUC8 MRNA expression in the first group (0.71 +/- 0.34) was lower than that of the second group (1.12 +/- -0.26).
  
  
  CONCLUSIONS
  DXM supress MUC8 MRNA expression in nasal polyps and this result provide another aspect for glucocorticoid's antiinflammatory mechanism.
authors.affiliation: Department of Otorhinolaryngology, Second Affiliated Hospital, Zhejiang University, Hang-zhou, 310009, China.
authors.forename: Jiyun
authors.initials: J
authors.lastname: Wang
authors.forename: Beibei
authors.initials: B
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000096:biosynthesis* / Q000235:genetics; D009298:Nasal Polyps / Q000188:drug therapy* / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: D000893:Anti-Inflammatory Agents; C105059:MUC8 protein, human; D009077:Mucins; D012333:RNA, Messenger; D003907:Dexamethasone