title: Recognition and stabilization of peptide alpha-helices using templatable nanoparticle receptors.
abstract: alpha-Helices are important structural elements in proteins. To provide a scaffold for the facial recognition of peptides, we have explored the interaction of cationic mixed monolayer protected clusters (MMPCs) with a tetra-aspartate peptide in water. In these studies, substantial enhancement of peptide helicity was observed upon addition of the MMPC. Significantly, this stabilization increased with time, demonstrating templation of the monolayer to the peptide helix.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Ayush
authors.initials: A
authors.lastname: Verma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakade
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Simard
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D006046:Gold / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D018000:Receptors, Peptide / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D010455:Peptides; D018000:Receptors, Peptide; C017645:polyaspartate; D006046:Gold