title: Intraoperative human vagus nerve compound action potentials.
abstract: OBJECTIVE
  Although electrical stimulation of vagus nerve is used widely for treatment of epilepsy the electrophysiological properties of human vagus nerve are not well characterized. Our objective was to measure compound action potentials of human vagus nerve fiber groups intraoperatively by stimulation using a commercially available generator and electrode system (Neurocybernetic Prosthesis System, NCP).
  
  
  METHODS
  During NCP implantation we recorded compound action potentials evoked by stimulating the left vagus nerve through the NCP bipolar lead. Current intensities were varied from 0.25 to 3.0 mA.
  
  
  RESULTS
  Vagus nerve compound action potential components conducting in the A, Adelta, and C velocity ranges could be elicited using either the NCP pulse generator or by a standard evoked potential instrument. A fiber potentials were recordable in all nerves, and were activated by very low stimulus currents. Adelta and C fibers were less reliably elicited, with C fibers requiring the highest currents.
  
  
  CONCLUSIONS
  Three clearly identified fiber populations can be identified using therapeutic electrical stimulation of the human vagus. Intraoperative measurements of NCP-induced action potentials may potentially provide a marker for therapeutic stimulation and better insight into mechanisms of vagus nerve stimulation (VNS) efficacy.
authors.affiliation: Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA. mevans@siumed.edu
authors.forename: M S
authors.initials: MS
authors.lastname: Evans
authors.forename: S
authors.initials: S
authors.lastname: Verma-Ahuja
authors.forename: D K
authors.initials: DK
authors.lastname: Naritoku
authors.forename: J A
authors.initials: JA
authors.lastname: Espinosa
mesh_terms: D000200:Action Potentials; D000328:Adult; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy; D004867:Equipment Design; D006801:Humans; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009431:Neural Conduction; D011930:Reaction Time; D014630:Vagus Nerve / Q000503:physiopathology* / Q000601:surgery