The science and practice of carcinogen identification and evaluation.
Several national and international health agencies have established programs with the aim of identifying agents and exposures that cause cancer in humans. Carcinogen identification is an activity grounded in the scientific evaluation of the results of human epidemiologic studies, long-term bioassays in experimental animals, and other data relevant to an evaluation of carcinogenicity and its mechanisms. In this commentary, after a brief discussion of the science basis common to the evaluation of carcinogens across different programs, we discuss in more detail the principles and procedures currently used by the IARC Monographs program.
Cogliano
Vincent James
VJ
International Agency for Research on Cancer, Lyon, France. cogliano@iarc.fr
Baan
Robert A
RA
Straif
Kurt
K
Grosse
Yann
Y
Secretan
Marie Béatrice
MB
El Ghissassi
Fatiha
F
Kleihues
Paul
P
D001681:Biological Assay; D002273:Carcinogens / Q000009:adverse effects* / Q000032:analysis*; D016265:Conflict of Interest; D016021:Epidemiologic Studies; D015386:Hazardous Substances; D006801:Humans; D007391:International Cooperation; D009369:Neoplasms / Q000139:chemically induced; D018570:Risk Assessment / Q000379:methods*
D002273:Carcinogens; D015386:Hazardous Substances