title: Feature selection for shape-based classification of biological objects.
abstract: This paper introduces a method for selecting subsets of relevant statistical features in biological shape-based classification problems. The method builds upon existing feature selection methodology by introducing a heuristic that favors the geometric locality of the selected features. This heuristic effectively reduces the combinatorial search space of the feature selection problem. The new method is tested on synthetic data and on clinical data from a study of hippocampal shape in schizophrenia. Results on clinical data indicate that features describing the head of the right hippocampus are most relevant for discrimination.
authors.affiliation: Medical Image Display and Analysis Group, University of North Carolina, Chapel Hill, NC, USA pauly@cs.unc.edu
authors.forename: Paul
authors.initials: P
authors.lastname: Yushkevich
authors.forename: Sarang
authors.initials: S
authors.lastname: Joshi
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Pizer
authors.forename: John G
authors.initials: JG
authors.lastname: Csernansky
authors.forename: Lei E
authors.initials: LE
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D003198:Computer Simulation; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008954:Models, Biological; D010363:Pattern Recognition, Automated; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013382:Subtraction Technique