Eyelid bleeding and atypical amyloidosis.
OBJECTIVE
To describe a case of atypical systemic amyloidosis in a patient who presented with recurrent subcutaneous bleeding of the eyelids and auricles.


METHODS
Observational case report.


METHODS
A 52-year-old man with chronic cardiac failure, hypertension, weight loss, and impotence presented with recurrent bleeding of the eyelids and auricles, and was investigated for suspected amyloidosis.


RESULTS
Biopsy specimens taken from the bone marrow, salivary gland, abdominal subcutaneous fat, and gastric mucosa, and eyelids were all negative for Congo red. Results of a conjunctival biopsy, which were returned after the patient's death, and cardiac muscle autopsy were positive for Congo red staining, indicating amyloidosis.


CONCLUSIONS
The findings in this case show that the presentation of amyloidosis may be atypical. Ophthalmologists should consider a diagnosis of amyloidosis in patients with periorbital bleeding, even if biopsies are negative for Congo red. A conjunctival biopsy may be useful in establishing a diagnosis of primary systemic amyloidosis.
Landa
Gennady
G
Department of Ophthalmology, Kaplan Medical Center, Rehovot 76100, Israel. genal@inter.net.il
Aloni
Eyal
E
Milshtein
Asher
A
Marcovich
Arie
A
Mozes
Marta
M
Pollack
Ayala
A
D000686:Amyloidosis / Q000175:diagnosis*; D005130:Eye Hemorrhage / Q000175:diagnosis*; D005141:Eyelid Diseases / Q000175:diagnosis*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged