[Relationship between glucocorticoid receptor and deficiency syndrome and the regulation of traditional Chinese medicine].
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily. Due to its almost ubiquitous expression, GR plays an important role in many physiological and pathological processes. These include regulation of homeostasis, adaptation to stress, and modulation of central nervous system. In addition, GR is a major modulator of the immune system due to its proficient anti-inflammatory and immunosuppressive activity; and its function is important for proper regulation of many physiological processes. The exploration on the regulation of traditional Chinese medicine on GR has established a modern physiological and pathological foundation for research of traditional Chinese medicine.
Li
Yong
Y
Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. liyong8256@sohu.com
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000592:standards; D008517:Phytotherapy; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D011965:Receptors, Glucocorticoid