Identification of 5-aminosalicylic acid, ciprofloxacin and azithromycin by abrasive stripping voltammetry.
Solid microparticles of 5-aminosalicylic acid, ciprofloxacin, and azithromycin were mechanically immobilized on the surface of the paraffin impregnated graphite electrode and investigated by square-wave and cyclic voltammetry in order to develop a method for their qualitative determination. 5-Aminosalicylic acid is oxidized at 0.540 V in the quasireversible electrode reaction, which is followed by the chemical transformation of the product, while ciprofloxacin and azithromycin are oxidized at 1.2 V and 0.94 V, respectively, in totally irreversible electrode reactions. The detection of these drugs in commercial dosage formulations is reported.
Komorsky-Lovrić
Sebojka
S
Center for Marine and Environmental Research, Rudjer Bosković Institute, Bijenicka 54, P.O. Box 180, 10002 Zagreb, Croatia. slovric@rudjer.irb.hr
Nigović
Biljana
B
D017963:Azithromycin / Q000032:analysis* / Q000737:chemistry; D002939:Ciprofloxacin / Q000032:analysis* / Q000737:chemistry; D004563:Electrochemistry; D004566:Electrodes; D006108:Graphite; D019804:Mesalamine / Q000032:analysis* / Q000737:chemistry; D010084:Oxidation-Reduction; D011208:Powders; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
D011208:Powders; D019804:Mesalamine; D002939:Ciprofloxacin; D006108:Graphite; D017963:Azithromycin