Effect of interleukin-1beta and glutathione S-transferase genotypes on the development of gastric mucosa-associated lymphoid tissue lymphoma.
e tested whether polymorphic variations in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and interleukin-1 (IL-1beta and IL-1RN) genes confer susceptibility to mucosa-associated lymphoid tissue lymphomas (MALT) in a Chinese population. The rates of GSTM1, GSTP1, IL-1beta and IL-1RN genotypes did not differ between patients and controls. However, GSTT1 null genotypes were significantly more common in patients with MALT lymphomas (43/75 vs. 138/321, p=0.029; OR=1.8, 95% CI: 1.1-3.0) than in controls. Our results suggest that a glutathione S-transferase defect plays a role in MALT lymphoma.
Wu
Ming-Shiang
MS
Shun
Chia-Tung
CT
Huang
Shih-Pei
SP
Cheng
Ann-Li
AL
Chen
Li-Tzong
LT
Lin
Jaw-Town
JT
D002681:China / Q000208:ethnology; D005753:Gastric Mucosa / Q000473:pathology; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D013274:Stomach Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D044465:White People
D007375:Interleukin-1; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase