[Effect of chronic abacterial prostatitis on semen quality and efficacy of antibacterial agents].
OBJECTIVE
To appraise the effect of chronic abacterial prostatitis (CAP) on semen quality and the efficacy of antibacterial agents.


METHODS
The semen of 86 cases of CAP and 20 normal men were analysed together with the antisperm antibodies in their blood and semen, and the antisperm antibodies in the blood and spermatic fluid were determined. Then the 86 patients were randomized into two groups, one treated with Chinese traditional medicine, indomethacin and three kinds of antibacterial agents, the other with Chinese traditional medicine and indomethacin only. The treatment lasted 3 months, and a follow-up visit was paid every month.


RESULTS
Sperm motility and normal modality of the CAP group were 59.8% and 52.8%, respectively, significantly lower than those of the normal group (P < 0.005). The positive rates of the antisperm antibodies in the blood and spermatic fluid were 46.5% and 50%, respectively, significantly higher than those of the normal group. The clinical efficacy was significantly better in the group treated with antibacterial agents than the one without (P < 0.05).


CONCLUSIONS
CAP can affect sperm quality and decrease fertility. Antibacterial agents can obviously enhance sperm quality and the cure rate of CAP.
Zhang
Jianguo
J
Department of Urology, the First Affiliated Hospital of Henan Science and Technology University, Luoyang, Henan 471003, China. jgzhang@126.com
Wang
Yanli
Y
Zhou
Siwei
S
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001323:Autoantibodies / Q000378:metabolism; D002908:Chronic Disease; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011472:Prostatitis / Q000188:drug therapy* / Q000276:immunology; D012661:Semen / Q000737:chemistry / Q000502:physiology; D013081:Sperm Motility; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D001323:Autoantibodies