[Flow cytometric DNA analysis and neoadjuvant chemotherapy of cervix cancer (stage IB2-IIIB)].
The purpose of the present study is to determine the predictive role of the data of flowcytometric DNA-analysis--aneuploidity DNA-index, proliferative index in patients with squamous cervical cancer who was given chemotherapy as a initial treatment. The data of 12 patients in stage IB2-IIIB, who were divided into two groups according to the second-line treatment--surgery of definitive radiotherapy, were analysed. These data were correlated with the respond of the tumor to neoadjuvant chemotherapy (clinical and histopathological) as well as other factors such as stage, size of tumor lesion, grading disease free survival. The method of flowcytometric DNA-analysis was presented briefly. The results we have obtained, although in quiete limited number of patients, are interesting and justify prospective studies of the problem.
Kornovskiĭ
Ia
Ia
Gorchev
G
G
Balev
S
S
Ivanova
F
F
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D004273:DNA, Neoplasm / Q000032:analysis*; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D020360:Neoadjuvant Therapy / Q000379:methods*; D009367:Neoplasm Staging; D011003:Ploidies; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology
D004273:DNA, Neoplasm