Porous ceramic bodies for drug delivery.
An approach to the production of ceramic drug delivery devices is proposed. Two examples of possible ceramics are dealt with: hydroxyapatite weakly modifiable by living tissue and the bioinert alumina. The possibility to control the formed porosity was taken into consideration for both materials. The ratio between the acquired porosity and the quantity and quality of the agents inducing porosity is also described and discussed. A test on the role of porosity was performed on the obtained porous ceramic bodies and a study was made on the release of a substance with pharmacological activity from previously impregnated porous ceramic bodies. This paper is preliminary to a planned work targeted to the preparation of ceramic drug delivery systems.
Krajewski
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A
Institute for Technological Research on Ceramics - C.N.R., Faenza, Italy. kraxi@irtec1.irtec.bo.cnr.it
Ravaglioli
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A
Roncari
E
E
Pinasco
P
P
Montanari
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L