title: [The clinical study on the adjunctive effects of aqueous extract from coptis root for the treatment of chronic periodontitis].
abstract: OBJECTIVE
  To make a therapeutic membrane with aqueous extract from coptis root and explore its adjunctive effects for treating chronic periodontitis.
  
  
  METHODS
  Drug membrane from coptis root aqueous extract was developed; 4 teeth in 30 patients with moderate to advanced periodontitis were randomly divided into four groups: coptis root membrane, iodine glycerin, single drug membrane and blank control group. All parameters including plaque index (PI), probing depth (PD), attachment loss (AL) and bleeding on probing (BOP) were measured at baseline, 4 and 7 weeks after treatment. Analysis of variance and chi-square test were carried out for analysis.
  
  
  RESULTS
  In all four groups, there were significant differences of PD, AL, BOP between baseline and 4,7 weeks after treatment (P<0.05), the treatment effect of coptis root membrane was significantly superior to that of other three groups (P<0.05). Moreover, all the parameters improved continuously.
  
  
  CONCLUSIONS
  Use of coptis root membrane as an adjunctive method after scaling can significantly improve the treatment effect of periodontitis.
authors.affiliation: Stomatology Hospital of Jinan.Jinan 250001, Shandong Province, China.
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Wu
authors.forename: Guang-Shui
authors.initials: GS
authors.lastname: Jiang
authors.forename: Shi-Zhou
authors.initials: SZ
authors.lastname: Zhagn
authors.forename: Hui-Zhi
authors.initials: HZ
authors.lastname: Bian
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D001599:Berberine / Q000008:administration & dosage* / Q000302:isolation & purification / Q000627:therapeutic use; D002908:Chronic Disease; D039323:Coptis / Q000737:chemistry*; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001599:Berberine