[Effect of Boschniakia rossica extract on free radicals in brain of D-galactose induced senile rats].
OBJECTIVE
To study the effect of Boschniakia rossica extract on free radicals in the brain of D-galactose induced senile rats.


METHODS
Sixty Wistar rats were randomly divided into normal group, model group (48 mg.kg(-1).d(-1) D-galactose, SC), Boschniakia rossica group (100, 150, 200 mg/kg ig and 48 mg.kg(-1).d(-1) D-galactose, SC). After 40 days, the activities of SOD, MAO and the content of MDA were measured with colorimetric method, and the histological changes were synchronously observed by electronic microscope.


RESULTS
Boschniakia rossica extract significantly increased the SOD activity, decreased the MDA content, and inhibited the MAO activity in the brain tissue. It was observed under microscope that Boschniakia rossica extract could retrieve the degeneration of mitochondrion.


CONCLUSIONS
Boschniakia rossica extract can clear the free radicals for D-galactose induced senile rats.
Piao
Long
L
Department of Histology and Embryology, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, China.
Zhang
Xue-Wu
XW
Jin
Xiang-Zi
XZ
Li
Shan-Hua
SH
D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D005690:Galactose / Q000494:pharmacology; D008297:Male; D008995:Monoamine Oxidase / Q000187:drug effects / Q000378:metabolism; D031670:Orobanchaceae; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D005609:Free Radicals; D010936:Plant Extracts; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase; D005690:Galactose