title: Rhabdomyolysis and compartment syndrome with coadministration of risperidone and simvastatin.
abstract: We report a case of rhabdomyolysis and acute compartment syndrome of the lower extremity in a schizophrenic patient taking risperidone following the addition of simvastatin to treat hyperlipidemia. We suspect that disrupted drug metabolism, resulting from interactions with cytochrome P450 enzymes, rapidly elevated drug plasma levels, which then led to muscle toxicity. Clinicians who pharmacologically treat medical comorbidities in patients receiving atypical antipsychotics must be proactive in anticipating potential drug-drug interactions.
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Webber
authors.forename: Waqar
authors.initials: W
authors.lastname: Mahmud
authors.forename: Jeffery D
authors.initials: JD
authors.lastname: Lightfoot
authors.forename: Anantha
authors.initials: A
authors.lastname: Shekhar
mesh_terms: D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003161:Compartment Syndromes / Q000139:chemically induced*; D004347:Drug Interactions; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced*; D018967:Risperidone / Q000009:adverse effects* / Q000627:therapeutic use; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D019821:Simvastatin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D000960:Hypolipidemic Agents; D019821:Simvastatin; D018967:Risperidone