title: [Immunometabolic effects of interactions involving fat- and water-soluble vitamins in toxic forms of anemia].
abstract: Phenylhydrazine or sodium nitrite injections reduce the functional metabolic activity of neutrophils (leukocytes) in the peripheral blood, suppress the development of humoral immune response and delayed type hypersensitivity, decrease the energetic potential and the antioxidant status of erythrocytes, and induce the appearance of immunosuppressive activity in these cells. Retinol acetate, tocopherol acetate, and phylloquinone administered in various pair combinations reduce the degree of changes in the parameters of nonspecific resistance and immunological reactivity. Pyridoxine and cobalamin increase the immunomodulating activity of erythrocytes modified by phylloquinone.
authors.forename: I L
authors.initials: IL
authors.lastname: Brovkina
authors.forename: A A
authors.initials: AA
authors.lastname: Konoplia
authors.forename: B S
authors.initials: BS
authors.lastname: Uteshev
mesh_terms: D000740:Anemia / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000975:Antioxidants / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008055:Lipids / Q000737:chemistry; D009504:Neutrophils / Q000378:metabolism; D010659:Phenylhydrazines / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite / Q000633:toxicity; D012995:Solubility; D014815:Vitamins / Q000737:chemistry / Q000494:pharmacology*; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D008055:Lipids; D010659:Phenylhydrazines; D014815:Vitamins; D014867:Water; C030299:phenylhydrazine; D012977:Sodium Nitrite