[Combined use of metformin and Diane35 in polycystic ovary syndrome].
The aim of our study was to compare the effect of Metformin applied independently to the effect of Metformin used in combination with Diane35, the latter given only during the first two months of the treatment.


METHODS
In this prospective, open clinical study, 30 women with PCOS were included, divided in two groups 15 women each. Group 1 received 850 mg Metformin twice a day and group 2 in which Diane35 was added to the same treatment only during the first two months of the investigation. In addition the following tests have been made--immune reactive insulin, total testosterone, SHBG, free androgen index, anthropometric and some biochemical indices.


RESULTS
Much better decreasing of the level of testosterone and free androgen index in group 2, without worsening of the anthropometric and biochemical indices.


CONCLUSIONS
The combination of Metformin with the intermittent application of Diane35 is an appropriate alternative for the pathogenic influence and clinical improvement of the symptoms of androgen excess in cases with PCOS.
Mitkov
M
M
Pekhlivanov
B
B
Terzieva
D
D
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D017373:Cyproterone Acetate / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome
D000726:Androgen Antagonists; D004338:Drug Combinations; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C032640:Cyproterone acetate, ethinyl estradiol drug combination; D008687:Metformin