[The effect of ladasten on the activity of cAMP-dependent protein kinases and the phosphorylation of proteins in brain cells of rats].
The effect of ladasten (50 mg/kg) on the activity of cAMP-dependent protein kinases (represented by protein kinase A (PKA)) in the soluble protein fraction of rat brain was studied. Changes in the PKA activity were monitored in the initial period of drug action (1-12 h). In this stage, ladasten increased the PKA activity, and the level of phosphorylation of one isoform of the main protein myelin (14 kD) and of the proteolipid protein (30 kD). It is concluded that the pharmacological activity of ladasten is related to both cAMP-dependent and cAMP-independent signaling systems.
Vakhitova
Iu V
IuV
Salimgareeva
M Kh
MKh
Seredenin
S B
SB
D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D008297:Male; D010766:Phosphorylation; D051381:Rats
C493151:N-(2-adamantyl)-N-p-bromophenylamine; D017868:Cyclic AMP-Dependent Protein Kinases; D000218:Adamantane