[Influence of Jieyu Huoxue Decoction on rehabilitation of patients with depression after cerebral infarction].
OBJECTIVE
To study the influence of Jieyu Huoxue Decoction on rehabilitation of patients with depression after cerebral infarction.


METHODS
Fifty four patients suffered from the depression after acute cerebral infarction were randomly divided into three groups: depression control group, fluoxetine treated group and Jieyu Huoxue Decoction treated group. Eighteen patients of cerebral infarction without depression were enrolled in the no depression control group randomly. The Zung self-rating depression scale (SDS), the modified Edinburgh-Scandinavia stroke scale (MESSS) and the activities of daily living (ADL) were evaluated before treatment, 30 and 60 days after treatment.


RESULTS
After 30 and 60 days of treatment, SDS evaluation of the Jieyu Huoxue Decoction treated group showed significant difference as compared with the condition before treatment and that of the depression control group (P < 0.05 or P < 0.01), MESSS evaluation and ADL evaluation also showed significant difference as compared with the condition before treatment and that of the depression control group (P < 0.05 or P < 0.01); there was no obvious difference between the fluoxetine treated group and the Jieyu Huoxue Decoction treated group, but the Jieyu Huoxue Decoction treated group showed fewer symptoms and less side effect.


CONCLUSIONS
Jieyu Huoxue Decoction can not only relieve depression after cerebral infarction, but also improve neurological functions.
Feng
Bei-Lei
BL
Department of Neurology, Shanghai Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200082, China. budfeng@yahoo.com.cn
Wang
Qiao-Chu
QC
Li
Zheng-Yuan
ZY
D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D002544:Cerebral Infarction / Q000534:rehabilitation*; D003863:Depression / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D011237:Predictive Value of Tests; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D005473:Fluoxetine