title: Synthesis and antibacterial evaluation of oxazolidin-2-ones structurally related to linezolid.
abstract: Compounds structurally related to the known antimicrobial drug linezolid were selected in order to evaluate the influence of electron-withdrawing properties and altered geometric features as a result of the N-substituent modification. After a preliminary study of molecular modeling, cinnamoyl-, pyridin- and pyrimidinoxazolidin-2-ones were synthesized. None of the new compounds showed antibacterial activity.
authors.affiliation: Department of Drug Sciences, University of Chieti, via dei Vestini, 66100 Chieti, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ammazzalorso
authors.forename: Rosa
authors.initials: R
authors.lastname: Amoroso
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Bettoni
authors.forename: Marialuigia
authors.initials: M
authors.lastname: Fantacuzzi
authors.forename: Barbara
authors.initials: B
authors.lastname: De Filippis
authors.forename: Letizia
authors.initials: L
authors.lastname: Giampietro
authors.forename: Cristina
authors.initials: C
authors.lastname: Maccallini
authors.forename: Domenico
authors.initials: D
authors.lastname: Paludi
authors.forename: Maria L
authors.initials: ML
authors.lastname: Tricca
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid