title: Functional roles of NKT cell in the immune system.
abstract: CD1d-restricted Natural Killer T cells (NKT cells), a novel lymphocyte lineage, are considered to play an intermediary role bridging innate and acquired immunity. This review discusses the characteristics of NKT cells and their biological significance in the immune system, and summarizes their in vivo functions observed in a number of pathological settings, including infectious diseases, cancer, autoimmunity, and transplantation. Further, we discuss recent data that have generated considerable interest in utilizing NKT cells as targets of new therapeutic interventions in various human diseases.
authors.affiliation: Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Suehiro-cho 1-7-22, Tsurumi, Yokohama, Kanagawa 230-0045, Japan. seino@rcai.riken.jp
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Seino
authors.forename: Masaru
authors.initials: M
authors.lastname: Taniguchi
mesh_terms: D000818:Animals; D018949:Antigens, CD1 / Q000096:biosynthesis*; D055610:Antigens, CD1d; D017209:Apoptosis; D015551:Autoimmunity; D017690:Cell Transplantation / Q000379:methods; D016207:Cytokines / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000628:therapy; D005699:Galactosylceramides / Q000378:metabolism; D006017:Glycolipids / Q000737:chemistry; D006801:Humans; D007107:Immune System; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000166:cytology* / Q000378:metabolism; D009103:Multiple Sclerosis / Q000276:immunology / Q000628:therapy; D009369:Neoplasms / Q000276:immunology
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D016207:Cytokines; D005699:Galactosylceramides; D006017:Glycolipids; C493154:alpha-galactosylceramide