Gene expression profile in experimental mesangial proliferative glomerulonephritis.
We analyzed gene expression in rat anti-Thy1 antibody-induced glomerulonephritis by using the cDNA microarray method. Ninety-seven genes that differed by more than 1.5-fold intensity in comparison with the controls were selected. Cluster analysis showed that the expression of genes associated with inflammation reached maximum levels at 24 h, while genes involved in the development of fibrosis increased at 7 days after injection. Microarray analysis of animal disease models may be a powerful approach for understanding the gene expression programs that underlie these disorders.
Izumi
Yasukatsu
Y
Department of Pharmacology, Osaka City University Graduate School of Medical Science, Japan. izumi@msic.med.osaka-cu.ac.jp
Izumiya
Yasuhiro
Y
Shiota
Masayuki
M
Yukimura
Tokihito
T
Shiojima
Satoshi
S
Yamada
Masateru
M
Kadowaki
Tadashi
T
Katsuma
Susumu
S
Hirasawa
Akira
A
Tsujimoto
Gozoh
G
Iwao
Hiroshi
H
D000818:Animals; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods* / Q000706:statistics & numerical data; D015432:Glomerulonephritis, Membranoproliferative / Q000235:genetics* / Q000473:pathology; D046228:Microarray Analysis / Q000379:methods / Q000706:statistics & numerical data; D051381:Rats; D017208:Rats, Wistar