title: Characterization of genotypic determinants in HR-1 and HR-2 gp41 domains in individuals with persistent HIV viraemia under T-20.
abstract: We analysed the genetic changes in gp41 in a population of 30 heavily pretreated HIV-1-infected patients failing on a T-20-containing salvage therapy. This study confirms the key role of the number of drugs presumed to be still effective associated with T-20 in the magnitude of the virological response. Our results suggest that only HR-1 sequencing is necessary to characterize resistance to T-20, and that HR-2 domain sequencing is probably not required.
authors.affiliation: Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
authors.forename: Jacques
authors.initials: J
authors.lastname: Reynes
authors.forename: Sabine
authors.initials: S
authors.lastname: Yerly
authors.forename: Nadine
authors.initials: N
authors.lastname: Ktorza
authors.forename: Michel
authors.initials: M
authors.lastname: Segondy
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Piot
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: Laurent
authors.initials: L
authors.lastname: Kaiser
authors.forename: Luc
authors.initials: L
authors.lastname: Perrin
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
mesh_terms: D024882:Drug Resistance, Viral; D000077560:Enfuvirtide; D005814:Genes, Viral; D015700:HIV Envelope Protein gp41 / Q000235:genetics* / Q000627:therapeutic use; D023581:HIV Fusion Inhibitors / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1; D006801:Humans; D009154:Mutation; D010446:Peptide Fragments / Q000627:therapeutic use; D017434:Protein Structure, Tertiary; D017422:Sequence Analysis, DNA; D017211:Treatment Failure
chemical_list: D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010446:Peptide Fragments; D000077560:Enfuvirtide