[Studying the mechanism of antiarrhythmic action of a tertiary derivative of lidocaine].
The investigation of electrophysiological parameters of the cardiac activity in cats showed that, a derivative of lidocaine with glutamic acid (anion), does not influence the cardiac pacemaker and the myocardial excitability of atrium and ventricles, but decreases the atrioventricular conduction and increases the refractory period of myocardium in the left ventricle of intact heart. Under the conditions of myocardial ischemia, LKhT-3-00 exhibits a negative chronotropic effect. Lidocaine glutamate increases the refractory period of atrium and decreases the excitability and refractory period of ventricles.
Blinov
D S
DS
Kostin
Ia V
IaV
Skachilova
S Ia
SIa
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D002415:Cats; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology; D012849:Sinoatrial Node / Q000187:drug effects / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D008012:Lidocaine