[Effect of kidney-warming and astringent therapy on plasma endothelin and interleukin-2 receptor in patients with nephrotic syndrome].
OBJECTIVE
To explore the effect and mechanism of kidney-warming and astringent therapy in treating nephrotic syndrome patients with deficiency of spleen and kidney yang and overflow of water, and to observe the change of plasma endothelin and interleukin-2 receptor after treatment.


METHODS
Forty-four patients were randomly divided into conventional steroid treated group (control group, 20 cases) and conventional steroid plus kidney-warming and astringent therapy treated group (treatment group, 24 cases). The levels of plasma endothelin (ET) and soluble interleukin-2 receptor (sIL-2) were observed.


RESULTS
Before treatment, plasma ET and sIL-2 in the patients were significantly higher than those in healthy people (P<0.01). After treatment, the ET and sIL-2 levels were obviously improved in both treated groups (P<0.05) and the improvement in the treatment group was more obvious. The difference between the two treated groups after treatment was significant (P<0.05).


CONCLUSIONS
Conventional treatment plus kidney-warming and astringent therapy can effectively improve the levels of plasma ET and sIL-2 in treating nephrotic syndrome patients with deficiency of spleen and kidney yang and overflow of water, and hence alleviate the damage of renal tissue.
Lu
Hui
H
Department of Internal Medicine, No. 211 Hospital of PLA, Haerbin, Heilongjiang Province 150080, China. lh898@up369.com
Wang
Yan-Yan
YY
Guo
Mei-Zhu
MZ
Wang
Chun-Li
CL
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood / Q000628:therapy*; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D000305:Adrenal Cortex Hormones; D016232:Endothelins; D015375:Receptors, Interleukin-2