Comparative study of lung cytologic features in normal rhesus (Macaca mulatta), cynomolgus (Macaca fasicularis), and African green (Chlorocebus aethiops) nonhuman primates by use of bronchoscopy.
Invasive bronchoscopy and bronchoaveolar lavage (BAL) fluid collection represents an important tool in studies of the respiratory system of nonhuman primates. Bronchoscopy and BAL fluid collection was performed on groups of rhesus (Macaca mulatta) and cynomolgus (Macaca fasicularis) macaques and African green monkeys (Chlorocebus aethiops), and the resulting comparative lavage cytologic features are described. Analysis of the BAL fluid did not reveal significant differences among species with respect to total cells recovered or differential cellular composition. This description of the method used to lavage the nonhuman primates and the resulting lung cytologic findings provide important comparative data for three species commonly used in biomedical research.
Tate
Mallory K
MK
Divisions of Veterinary Medicine, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 20702-5011, USA.
Rico
Pedro J
PJ
Roy
Chad J
CJ
D000818:Animals; D018893:Bronchoalveolar Lavage / Q000379:methods; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D001999:Bronchoscopy; D002522:Chlorocebus aethiops / Q000033:anatomy & histology*; D006801:Humans; D008168:Lung / Q000166:cytology*; D008252:Macaca fascicularis / Q000033:anatomy & histology*; D008253:Macaca mulatta / Q000033:anatomy & histology*