title: [Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism].
abstract: OBJECTIVE
  To study the effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental oral precancerous lesion and its mechanism.
  
  
  METHODS
  We treated the experimental oral precancerous lesion in hamster's cheek pouch using 1023 Recipe (consisting of Radix Astragali, Gynostemma Pentaphyllum, Rhizoma Chuanxiong and selenium-rich green tea) for 6 weeks, and observed its effect in blocking cancer transformation, detected 2 kinds of agglutinin receptors (receptors of wheat germ agglutinin and Ricinus communis agglutinin) in the mucosa of the hamster's cheek pouch.
  
  
  RESULTS
  The rate of cancer transformation in 1023 Recipe treated group was lower than that in the control group without treatment (P<0.05). Agglutinin receptors in the two groups were different significantly.
  
  
  CONCLUSIONS
  1023 Recipe is effective in treating hyperplasia, and can prevent its cancer transformation. The mechanism may be that 1023 Recipe can induce precancerous lesions to differentiate into normal tissues.
authors.affiliation: Xiamen Hospital of Stomatalogy, Xiamen, Fujian Province 361001, China. zuoliangc@yahoo.com.cn
authors.forename: Zuo-Liang
authors.initials: ZL
authors.lastname: Chen
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Guan
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Chen
authors.forename: Jin-Chun
authors.initials: JC
authors.lastname: Chen
mesh_terms: D000373:Agglutinins / Q000378:metabolism; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D006224:Cricetinae; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009369:Neoplasms / Q000473:pathology / Q000517:prevention & control*; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D014909:Wheat Germ Agglutinins / Q000378:metabolism
chemical_list: D000373:Agglutinins; D004365:Drugs, Chinese Herbal; D014909:Wheat Germ Agglutinins