NALT- versus Peyer's-patch-mediated mucosal immunity.
Recent studies indicate that the mechanism of nasopharynx-associated lymphoid tissue (NALT) organogenesis is different from that of other lymphoid tissues. NALT has an important role in the induction of mucosal immune responses, including the generation of T helper 1 and T helper 2 cells, and IgA-committed B cells. Moreover, intranasal immunization can lead to the induction of antigen-specific protective immunity in both the mucosal and systemic immune compartments. Therefore, a greater understanding of the differences between NALT and other organized lymphoid tissues, such as Peyer's patches, should facilitate the development of nasal vaccines.
Kiyono
Hiroshi
H
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. kiyono@ims.u-tokyo.ac.jp
Fukuyama
Satoshi
S
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D008198:Lymph Nodes / Q000196:embryology / Q000276:immunology / Q000378:metabolism; D009305:Nasopharynx / Q000276:immunology*; D010581:Peyer's Patches / Q000196:embryology / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines