title: Hepatic lymphoma metastasis presenting with severe acute liver failure: a rare case.
abstract: Hepatic lymphoma metastasis is rare, and should always be considered in the differential diagnosis of hepatic malignancy. A 52-year-old man presented with a four-day history of fever, fatigue, yellowish skin and nausea. His past medical history was unremarkable. There was no history of alcohol intake or medications. His physical examination revealed generalized jaundice and hepatomegaly. His blood tests showed liver failure and coagulopathy. Abdominal ultrasonography illustrated hepatomegaly. A further work-up included bone marrow and liver biopsy. The pathology report was B-cell lymphoma. He was treated with chemotherapy, and his laboratory findings during follow-up showed steady improvement. In conclusion, lymphoma metastasis to liver can be a cause of liver dysfunction. A high index of suspicion is required for the diagnosis. We emphasize the importance of obtaining tissue sample in all patients with suspicious lesion in any organ to avoid missing the rare but curable pathologies.
authors.affiliation: Department of Internal Medicine, Medical School, Başkent University, Ankara, Turkey. drkanbay@yahoo.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
authors.forename: Gürden
authors.initials: G
authors.lastname: Gür
authors.forename: Murat
authors.initials: M
authors.lastname: Korkmaz
authors.forename: Beyhan
authors.initials: B
authors.lastname: Demirci
authors.forename: Sedat
authors.initials: S
authors.lastname: Boyacioğlu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D017114:Liver Failure, Acute / Q000188:drug therapy / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy / Q000556:secondary*; D016393:Lymphoma, B-Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents