title: Positron-emission tomography in prognostic and therapeutic assessment of lung cancer: systematic review.
abstract: Positron-emission tomography (PET) with 18-fluorodeoxyglucose has a role in the diagnosis and staging of lung cancer, but is also appealing for assessment of prognosis and treatment. A systematic search of the published work shows good evidence that [(18)F]FDG uptake on PET has independent prognostic value in newly diagnosed non-small-cell lung cancer. PET is a sensitive method of measuring the biological effects of anticancer therapy, but until better standardisation and large-scale experience is available, it should only be used for additional assessments of early response in clinical trials. Further studies are needed to define the role of [(18)F]FDG-PET in restaging after induction therapy in multimodality approaches for locally advanced lung cancer. The assessment of prognosis by [(18)F]FDG-PET is less substantiated in treated lung cancer than in newly diagnosed patients. Good prospective evidence documents the effectiveness of [(18)F]FDG-PET over CT in the correct identification of recurrent lung cancer.
authors.affiliation: Clinical Trial Unit, Department of Pulmonology, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium. johan.vansteenkiste@uz.kuleuven.ac.be
authors.forename: Johan
authors.initials: J
authors.lastname: Vansteenkiste
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Fischer
authors.forename: Christophe
authors.initials: C
authors.lastname: Dooms
authors.forename: Jann
authors.initials: J
authors.lastname: Mortensen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D011379:Prognosis; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18