title: [Detection of antibody against Borna disease virus-p24 in the plasma of Chinese patients with chronic fatigue syndrome by Western-blot analysis].
abstract: OBJECTIVE
  To evaluate the prevalence of infection with Borna disease virus (BDV) in Chinese patients with chronic fatigue syndrome (CFS) and control subjects, and to discuss the etiological association between CFS and infection with BDV.
  
  
  METHODS
  The CDC (1994) diagnostic criteria for CFS were used for case definition. Sixty-one patients suffered from CFS were from 11 Provinces in China. To detect the antibody against BDV-p24 on the plasma samples from all cases and 73 healthy control subjects by Western-blotting analysis.
  
  
  RESULTS
  7 of the sixty-one cases and 0 of the controls were sero-positive for BDV-p24 antibody, there was a statistical significant difference between the two groups (11.48% vs 0%; P less than 0.010).
  
  
  CONCLUSIONS
  Chinese patients with CFS showed sero-positive identifying BDV infection, by comparison, anti.BDV-p24 antibody prevalence in patients was significantly higher than in controls. An etiological association may exist between CFS and BDV infection.
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Beijing 100050, China.
authors.forename: Yong-jie
authors.initials: YJ
authors.lastname: Li
authors.forename: De-xin
authors.initials: DX
authors.lastname: Wang
authors.forename: Feng-min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Zhan-dong
authors.initials: ZD
authors.lastname: Liu
authors.forename: Ai-ying
authors.initials: AY
authors.lastname: Yang
authors.forename: K
authors.initials: K
authors.lastname: Ykuta
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D015153:Blotting, Western; D001890:Borna Disease / Q000150:complications* / Q000276:immunology; D001891:Borna disease virus / Q000276:immunology*; D015673:Fatigue Syndrome, Chronic / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000914:Antibodies, Viral