title: A method for comparing electrophysiological, psychophysical, and structural measures of glaucomatous damage.
abstract: OBJECTIVE
  To develop a method for comparing multifocal visual-evoked potential (mfVEP) responses and behaviorally determined visual fields with structural measures of the optic nerve head.
  
  
  METHODS
  Humphrey 24-2 visual fields and mfVEPs were obtained from each eye of 20 patients with open-angle glaucoma. Monocular and interocular analyses were performed to identify locations with abnormal mfVEP responses. Optic discs were assessed with a confocal scanning laser ophthalmoscope (Heidelberg Retina Tomograph II). The image of the optic nerve head was divided into 6 sectors. The rim and disc area measurements for each sector were compared with those in a normal database using Moorfields regression analysis. The optic nerve head measurements for the 6 sectors were related to the Humphrey visual field locations and the 60 sectors of the mfVEP display.
  
  
  RESULTS
  Of 240 sectors tested (40 eyes x 6 sectors), 18.8% on Humphrey visual field, 22.1% on mfVEP, and 10.8% on confocal scanning laser ophthalmoscopic testing were significantly different from those of control subjects. There were no significant deficits in 165 sectors. There was agreement for 86.7% of the sectors when the Humphrey visual field and mfVEP results were compared. The confocal scanning laser ophthalmoscopic results were in agreement for 84.6% of these sectors.
  
  
  CONCLUSIONS
  The method used allows for a comparison among measures of visual function and a structural measure of the optic nerve head. In general, the results of the functional and structural measures showed agreement; however, there were clear examples of disagreements that merit further study.
authors.affiliation: Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, 635 W 168th Street, New York, NY 10032, USA.
authors.forename: Vivienne C
authors.initials: VC
authors.lastname: Greenstein
authors.forename: Phamornsak
authors.initials: P
authors.lastname: Thienprasiddhi
authors.forename: Robert
authors.initials: R
authors.lastname: Ritch
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Liebmann
authors.forename: Donald C
authors.initials: DC
authors.lastname: Hood
mesh_terms: D000328:Adult; D000368:Aged; D004594:Electrophysiology; D005074:Evoked Potentials, Visual; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011601:Psychophysics; D015203:Reproducibility of Results; D014786:Vision Disorders / Q000175:diagnosis*; D014792:Visual Acuity; D014794:Visual Fields