title: Efficacy of selamectin in the treatment of nasal mite (Pneumonyssoides caninum) infection in dogs.
abstract: In a laboratory study to evaluate the efficacy of selamectin for treatment of canine nasal mite infection, 12 purpose-bred beagles were experimentally infected with Pneumonyssoides caninum (P. caninum). Six of the dogs were treated with selamectin applied to the skin of the back at dosages of 6 to 24 mg/kg for three times at 2-week intervals. The remaining six dogs were an untreated control group. At necropsy 39 to 46 days after inoculation, no P. caninum mites were found in any of the treated dogs. In contrast, nasal mites were found in five of the untreated dogs. This difference was statistically significant at P=0.015.
authors.affiliation: Department of Parasitology (SWEPAR), National Veterinary Institute (SVA), and the Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.
authors.forename: Lotta
authors.initials: L
authors.lastname: Gunnarsson
authors.forename: Göran
authors.initials: G
authors.lastname: Zakrisson
authors.forename: Dan
authors.initials: D
authors.lastname: Christensson
authors.forename: Arvid
authors.initials: A
authors.lastname: Uggla
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D008925:Mites / Q000187:drug effects / Q000254:growth & development; D009296:Nasal Cavity / Q000469:parasitology*; D011897:Random Allocation; D016896:Treatment Outcome
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C414354:selamectin