Effects of malnutrition on cytochrome P450 1A2 activity in elderly patients.
Little is known of the influence of nutritional status on cytochrome P450 (CYP) 1A2 activity in elderly patients. Thirty elderly institutionalised patients with malnutrition (group A, aged 88 +/- 5 years) and 24 without (group B, aged 81 +/- 9 years) were included. Malnutrition was defined as weight loss of >10% over the previous 6 months and/or a body mass index (BMI) <21 kg/m2 and albuminaemia < or = 32 g/L. CYP1A2 activity was evaluated by the plasma paraxanthine/caffeine (PAX/CAF) metabolic ratio. The plasma PAX/CAF metabolic ratio was similar in both groups regardless of nutritional status (0.34 +/- 0.13 [A] versus 0.30 +/- 0.11 [B]; p = 0.11). The CYP1A2 metabolic ratio was not correlated to either BMI, serum albumin or renal clearance. CYPI A2 activity, as measured by the plasma PAX/CAF ratio, was not influenced by nutritional status in elderly patients.
Hamon-Vilcot
Brigitte
B
Département de Gériatrie, Hôpital Charles Foix, Ivry-sur-Seine, France.
Simon
Tabassome
T
Becquemont
Laurent
L
Poirier
Jean-Marie
JM
Piette
François
F
Jaillon
Patrice
P
D000368:Aged / Q000502:physiology*; D000369:Aged, 80 and over; D002110:Caffeine; D019363:Cytochrome P-450 CYP1A1 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000201:enzymology*; D008875:Middle Aged; D009752:Nutritional Status; D010641:Phenotype; D010726:Phosphodiesterase Inhibitors
D010726:Phosphodiesterase Inhibitors; D002110:Caffeine; D019363:Cytochrome P-450 CYP1A1