title: Comparison of the effects of caudal pole hemi-meniscectomy and complete medial meniscectomy in the canine stifle joint.
abstract: OBJECTIVE
  To compare the effects of caudal pole hemi-meniscectomy (CPHM) and complete medial meniscectomy (MM), specifically with respect to development of secondary osteoarthritis, in the stifle joints of clinically normal dogs.
  
  
  METHODS
  14 large-breed dogs.
  
  
  METHODS
  Unilateral CPHM (7 dogs) or MM (7) was performed, and the left stifle joints served as untreated control joints. Gait was assessed in all dogs before surgery and at 4, 8, 12, and 16 weeks postoperatively. After euthanasia, joints were evaluated grossly; Mankin cartilage scores, subchondral bone density assessment, and articular cartilage proteoglycan extraction and western blot analyses of 3B3(-) and 7D4 epitopes were performed.
  
  
  RESULTS
  Weight distribution on control limbs exceeded that of treated limbs at 4 and 16 weeks after surgery in the CPHM group and at 4 and 8 weeks after surgery in the MM group; weight distribution was not significantly different between the 2 groups. After 16 weeks, incomplete meniscal regeneration and cartilage fibrillation on the medial aspect of the tibial plateau and medial femoral condyle were detected in treated joints in both groups. Mankin cartilage scores, subchondral bone density, and immunoexpression of 3B3(-) or 7D4 in articular cartilage in CPHM- or MM-treated joints were similar; 7D4 epitope concentration in synovial fluid was significantly greater in the MM-treated joints than in CPHM-treated joints.
  
  
  CONCLUSIONS
  Overall severity of secondary osteoarthritis induced by CPHM and MM was similar. Investigation of 7D4 epitope concentration in synovial fluid suggested that CPHM was associated with less disruption of chondrocyte metabolism.
authors.affiliation: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Johnson
authors.forename: D J
authors.initials: DJ
authors.lastname: Francis
authors.forename: P A
authors.initials: PA
authors.lastname: Manley
authors.forename: Q
authors.initials: Q
authors.lastname: Chu
authors.forename: B
authors.initials: B
authors.lastname: Caterson
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001837:Body Weights and Measures; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology; D002356:Cartilage / Q000378:metabolism / Q000473:pathology; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005684:Gait / Q000502:physiology; D006652:Histological Techniques; D008592:Menisci, Tibial / Q000601:surgery*; D010003:Osteoarthritis / Q000209:etiology / Q000662:veterinary*; D011509:Proteoglycans / Q000378:metabolism; D013264:Stifle / Q000601:surgery*; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D011509:Proteoglycans