title: Determinant of left atrial dilation in patients with hypertrophic cardiomyopathy: a real-time 3-dimensional echocardiographic study.
abstract: To identify the determinants of left atrial (LA) dilation for patients with hypertrophic obstructive cardiomyopathy (HOCM), first we validated LA volume determination by real-time 3-dimensional echocardiography using magnetic resonance imaging in patients. Subsequently, real-time 3-dimensional echocardiography and 2-dimensional Doppler echocardiography were performed in 60 patients with HOCM and in 17 age-matched control subjects. LA volumes and left ventricular (LV) filling pressures were higher for patients with HOCM than in control subjects. By stepwise multilinear regression analysis, LV end-diastolic pressure, resting LV outflow tract pressure gradient, and LV wall thickness were significant determinants of LA dilation. However, tau, -dP/dt, LV stiffness, provokable pressure gradient, and mitral regurgitation did not have any independent relationship with LA volumes. Therefore, it is concluded that LA volume can be accurately determined by real-time 3-dimensional echocardiography; and LA dilation in patients with HOCM is related to LV filling pressure, LV outflow tract pressure gradient, and LV wall thickness.
authors.affiliation: Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bauer
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shiota
authors.forename: Richard D
authors.initials: RD
authors.lastname: White
authors.forename: Harry M
authors.initials: HM
authors.lastname: Lever
authors.forename: Jian Xin
authors.initials: JX
authors.lastname: Qin
authors.forename: Jeannie
authors.initials: J
authors.lastname: Drinko
authors.forename: Maureen
authors.initials: M
authors.lastname: Martin
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsujino
authors.forename: Marta
authors.initials: M
authors.lastname: Sitges
authors.forename: Yong Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: James D
authors.initials: JD
authors.lastname: Thomas
mesh_terms: D016279:Atrial Function, Left / Q000502:physiology; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging; D019560:Echocardiography, Three-Dimensional; D006325:Heart Atria / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013997:Time Factors