Inflammatory bowel disease and sclerosing cholangitis with ulcerative lesions on skin and soft palate.
Described is a 15-year-old boy who presented with an ulcerative destructive soft palate lesion, skin lesions, and prolonged history of weakness and abdominal pain associated with abnormal liver functions. A midline destructive lesion was considered. However biopsies revealed chronic inflammation. After thorough investigation including colon, liver, skin and uvular biopsies a diagnosis of Inflammatory Bowel Disease in association of Autoimmune Sclerosing Cholangitis was made. Treatment with steroids improved his symptoms, normalized liver functions and enhanced healing of the skin and palatal lesions. This case demonstrates the involvement of the palate in a rare systemic disease and to our knowledge is the first description of Sclerosing Cholangitis presenting as an ulcerative lesion of the soft palate.
Fishman
Gadi
G
Pediatric Otolaryngology Unit, Dana Children's Hospital, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, 6 Weizmann St., 64239, Israel. nognet@sbcglobal.net
DeRowe
Ari
A
Wasserman
Dror
D
Leider-Trejo
Lionora
L
Reif
Shimon
S
D000293:Adolescent; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D019226:Oral Ulcer / Q000209:etiology / Q000473:pathology*; D010160:Palate, Soft / Q000473:pathology*; D012867:Skin / Q000473:pathology*