Lasonolides C-g, five new lasonolide compounds from the sponge Forcepia sp.
Five new marine-derived macrolide compounds, lasonolides C (3), D (4), E (5), F (6), and G (7), have been isolated from the sponge Forcepia sp. along with the parent compound in the series, lasonolide A (1). Their structures were elucidated on the basis of spectral data. Compounds 3-5 inhibit the in vitro proliferation of A-549 human lung adenocarcinoma cells with IC50's of 0.13, 4.5, and 0.31 microM, respectively. Compounds 3-6 inhibit the in vitro proliferation of PANC-1 human pancreatic carcinoma cells with IC50's of 0.38, 4.89, 0.57, and 15.6 microM, respectively. Compound 3 inhibits the in vitro proliferation of the NCI-ADR-RES cell line with an IC50 of 1.12 microM.
Wright
Amy E
AE
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, Florida 34946, USA. wright@hboi.edu
Chen
Ying
Y
Winder
Priscilla L
PL
Pitts
Tara P
TP
Pomponi
Shirley A
SA
Longley
Ross E
RE
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005431:Florida; D006801:Humans; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018942:Macrolides; C450700:lasonolide A