Resetting the clock: Dexras1 defines a path.
The signaling pathways by which light and activity shift the circadian clock are not well understood. In this issue of Neuron, Cheng et al. analyze mice lacking Dexras1 (a Ras family GTPase protein) and demonstrate an important role for G(i/o) signaling mediating both photic and nonphotic phase shifts of the circadian clock.
Van Gelder
Russell N
RN
Department of Ophthalmology and Visual Sciences, Washington University Medical School, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
D000818:Animals; D001683:Biological Clocks / Q000235:genetics*; D002940:Circadian Rhythm / Q000235:genetics*; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D051379:Mice; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D018631:ras Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
C400132:RASD1 protein, human; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D019204:GTP-Binding Proteins; C498511:Rasd1 protein, mouse; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D018631:ras Proteins