title: Does sodium fluoride in bone cement affect implant fixation? Part I: bone tissue response, implant fixation and histology in nine rabbits.
abstract: The addition of sodium fluoride to poly (methyl-methacrylate) (PMMA) bone cement may theoretically improve the fixation of joint replacement. This hypothesis was tested in an animal model using nine mature healthy lop-eared rabbits. A femoral prosthesis was inserted in both knees to resurface the patellofemoral articulation. The same acrylic cement, with and without sodium fluoride, was randomised between the two sides for prosthetic fixation. Two screw shaped implants machined from cured rods of either cement were also inserted bilaterally into the proximal tibia. Qualitative and quantitative histomorphometry of the bone tissue response surrounding the cement in the femur and the intact tibial implants revealed similar results regardless of sodium fluoride addition. Six weeks after surgery removal, torque did not significantly differ between the two sides. Our findings indicate that addition of sodium fluoride to PMMA has little effect on implant stability and bone remodeling in rabbits in the short-term.
authors.affiliation: Department of Biomaterials/Handicap Research, Sahlgrenska University Hospital, Institute for Surgical Sciences, University of Gothenburg, Göteborg, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Sundfeldt
authors.forename: Michael
authors.initials: M
authors.lastname: Widmark
authors.forename: Ann
authors.initials: A
authors.lastname: Wennerberg
authors.forename: Johan
authors.initials: J
authors.lastname: Kärrholm
authors.forename: Carina B
authors.initials: CB
authors.lastname: Johansson
authors.forename: Lars V
authors.initials: LV
authors.lastname: Carlsson