Microdosimetry of neutron field for boron neutron capture therapy at Kyoto university reactor.
Microdosimetric single event spectrum in a human body simulated by an acrylic phantom has been measured for the clinical BNCT field at the Kyoto University Reactor (KUR). The recoil particles resulting from the initial reaction and subsequent interactions, namely protons, electrons, alpha particles and carbon nuclei are identified in the microdosimetric spectrum. The relative contributions to the neutron dose from proton, alpha particles and carbon are estimated to be about 0.9, 0.07 and 0.3, respectively, four depths between 5 and 41 mm. We estimate that the dose averaged lineal energy, yD decreased with depth from 64 to 46 keV microm(-1). Relative biological effectiveness (RBE) of this neutron field using a response function for the microdosimetric spectrum was estimated to decrease from 3.6 to 2.9 with increasing depth.
Endo
S
S
Quantum Energy Applications, Graduate School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527, Japan. endos@hiroshima-u.ac.jp
Onizuka
Y
Y
Ishikawa
M
M
Takada
M
M
Sakurai
Y
Y
Kobayashi
T
T
Tanaka
K
K
Hoshi
M
M
Shizuma
K
K
D000046:Academic Medical Centers; D001822:Body Burden; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis / Q000379:methods*; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D007564:Japan; D009502:Neutrons / Q000627:therapeutic use*; D009688:Nuclear Reactors; D011835:Radiation Protection / Q000295:instrumentation*; D011874:Radiometry / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity