title: Enantioseparation using sulfated cyclosophoraoses as a novel chiral additive in capillary electrophoresis.
abstract: Highly sulfated cyclosophoraoses (HS-Cys) were synthesized by the chemical modification of a family of neutral cyclosophoraoses isolated from Rhizobium leguminosarum bv. trifolii. The HS-Cys were then analytically characterized using Fourier transform-infrared spectroscopy and elemental analysis. These HS-Cys were successfully used as a novel chiral additive, in low-pH aqueous background electrolytes, for capillary electrophoretic separation of five basic chiral drugs such as arterenol, atenolol, isoproterenol, propranolol, and metoprolol.
authors.affiliation: Department of Advanced Fusion Technology, Bio/Molecular Informatics Center, Konkuk University, Seoul, South Korea.
authors.forename: Heylin
authors.initials: H
authors.lastname: Park
authors.forename: Sanghoo
authors.initials: S
authors.lastname: Lee
authors.forename: Simook
authors.initials: S
authors.lastname: Kang
authors.forename: Yunjung
authors.initials: Y
authors.lastname: Jung
authors.forename: Seunho
authors.initials: S
authors.lastname: Jung
mesh_terms: D001262:Atenolol / Q000737:chemistry / Q000302:isolation & purification; D004573:Electrolytes; D019075:Electrophoresis, Capillary / Q000379:methods*; D007545:Isoproterenol / Q000737:chemistry / Q000302:isolation & purification; D008790:Metoprolol / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D009638:Norepinephrine / Q000737:chemistry / Q000302:isolation & purification; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification*; D011433:Propranolol / Q000737:chemistry / Q000302:isolation & purification; D016961:Rhizobium leguminosarum / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004573:Electrolytes; D009844:Oligosaccharides; D001262:Atenolol; D011433:Propranolol; D008790:Metoprolol; D007545:Isoproterenol; D009638:Norepinephrine