title: A new, empirically established hypochondriasis diagnosis.
abstract: OBJECTIVE
  The narrow ICD-10 and DSM-IV definition of hypochondriasis makes it rarely used yet does not prevent extensive diagnosis overlap. This study identified a distinct hypochondriasis symptom cluster and defined diagnostic criteria.
  
  
  METHODS
  Consecutive patients (N=1,785) consulting primary care physicians for new illness were screened for somatization, anxiety, depression, and alcohol abuse. A stratified subgroup of 701 patients were interviewed with the Schedules for Clinical Assessment in Neuropsychiatry and questions addressing common hypochondriasis symptoms. Symptom patterns were analyzed by latent class analysis.
  
  
  RESULTS
  Patients fell into three classes based on six symptoms: preoccupation with the idea of harboring an illness or with bodily function, rumination about illness, suggestibility, unrealistic fear of infection, fascination with medical information, and fear of prescribed medication. All symptoms, particularly rumination, were frequent in one of the classes. Classification allowed definition of new diagnostic criteria for hypochondriasis and division of the cases into "mild" and "severe." The weighted prevalence of severe cases was 9.5% versus 5.8% for DSM-IV hypochondriasis. Compared with DSM-IV hypochondriasis, this approach produced less overlap with other somatoform disorders, similar overlap with nonsomatoform psychiatric disorders, and similar assessments by primary care physicians. Severe cases of the new hypochondriasis lasted 2 or more years in 54.3% of the subjects and 1 month or less in 27.2%.
  
  
  CONCLUSIONS
  These results suggest that rumination about illness plus at least one of five other symptoms form a distinct diagnostic entity performing better than the current DSM-IV hypochondriasis diagnosis. However, these criteria are preliminary, awaiting cross-validation in other subject groups.
authors.affiliation: Research Unit for Functional Disorders, Aarhus University Hospital, DK-8000 Aarhus C, Denmark. flip@akh.aaa.dk
authors.forename: Per
authors.initials: P
authors.lastname: Fink
authors.forename: Eva
authors.initials: E
authors.lastname: Ørnbøl
authors.forename: Tomas
authors.initials: T
authors.lastname: Toft
authors.forename: Kaj Christensen
authors.initials: KC
authors.lastname: Sparle
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Frostholm
authors.forename: Frede
authors.initials: F
authors.lastname: Olesen
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000453:epidemiology; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D003718:Denmark / Q000453:epidemiology; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D006998:Hypochondriasis / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D008297:Male; D008403:Mass Screening / Q000379:methods; D010555:Personality Inventory; D011320:Primary Health Care / Q000379:methods; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D011594:Psychometrics; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013001:Somatoform Disorders / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D009626:Terminology as Topic