Synthesis of DNA mimics representing HypNA-pPNA hetero-oligomers.
The methods for the synthesis and purification of negatively charged peptide nucleic acid (PNA)-relative deoxyribonucleic acid (DNA) mimics containing alternating residues of phosphono peptide nucleic acid (pPNA) monomers and PNA-like monomers on the base of trans-4-hydroxy-L-proline are described. Examples of the chimeric oligomers hybridization with complementary DNA and ribonucleic acid fragments are demonstrated.
Efimov
Vladimir A
VA
Institute of Bio-organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Chakhmakhcheva
Oksana G
OG
D001483:Base Sequence; D001704:Biopolymers / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D018716:Molecular Mimicry; D020135:Peptide Nucleic Acids / Q000737:chemistry*
D001704:Biopolymers; D020135:Peptide Nucleic Acids; D004247:DNA