title: How drug-drug interactions can impact managed care.
abstract: DDIs have important implications for managed care. They can adversely impact patient outcomes and can also have serious cost implications. The problem posed by unintended and adverse DDIs will continue to grow in importance as the complexity and uniqueness of medication regimens escalate in an aging population using increasingly sophisticated and varied pharmacological agents. In this paper, antidepressants and SSRIs in particular were used to illustrate these important points.
authors.affiliation: Department of Psychiatry and Behavior Sciences, University of Kansas, School of Medicine, and Psychiatric Research Institute, Wichita, USA.
authors.forename: Sheldon H
authors.initials: SH
authors.lastname: Preskorn
mesh_terms: D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D011307:Drug Prescriptions / Q000145:classification; D004359:Drug Therapy, Combination; D006801:Humans; D008329:Managed Care Programs / Q000458:organization & administration*; D010818:Practice Patterns, Physicians'; D016896:Treatment Outcome; D014481:United States
chemical_list: D000928:Antidepressive Agents; D003577:Cytochrome P-450 Enzyme System