Transient appearance of lactate dehydrogenase (LDH)-linked immunoglobulin and thyroid dysfunction at the postpartum period.
Here, we report a 28-year-old woman who transiently showed lactate dehydrogenase (LDH)-linked immunoglobulin during postpartum thyroiditis. She demonstrated high levels of serum LDH (794 IU/l) and thyroid hormones 7 months after delivery. Electrophoretic isoenzyme analysis of LDH showed an abnormal broadband caused by LDH-linked immunoglobulin (IgG-kappa). Transient thyrotoxicosis due to postpartum thyroiditis improved without any specific treatment, and elevated serum concentration of LDH decreased to the normal level (395 IU/l) with disappearance of LDH-linked IgG. LDH-linked immunoglobulin may also appear at the postpartum period.
Izumi
Yasumori
Y
First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki.
Morita
Shigeki
S
Ueda
Yasuo
Y
Origuchi
Tomoki
T
Eguchi
Katumi
K
D000328:Adult; D001774:Blood Chemical Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000276:immunology* / Q000378:metabolism; D049590:Postpartum Period; D011247:Pregnancy; D012075:Remission, Spontaneous; D018570:Risk Assessment; D012720:Severity of Illness Index; D013960:Thyroid Function Tests; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis*
D018828:Immunoglobulins, Thyroid-Stimulating; D007770:L-Lactate Dehydrogenase