Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease.
Fibroblast growth factor 1 (FGF1, also known as acidic FGF) protects selective neuronal populations against neurotoxic effects such as those in Alzheimer's disease (AD) and HIV encephalitis. The FGF1 gene is therefore a strong candidate gene for AD. Using the promoter polymorphism of the FGF1 gene, we examined the relationship between AD and the FGF1 and apolipoprotein E (APOE) genes in 100 Japanese autopsy-confirmed late-onset AD patients and 106 age-matched non-demented controls. The promoter polymorphism (-1385 A/G) was significantly associated with AD risk. The odds ratio for AD associated with the GG vs non-GG genotype was 2.02 (95% CI = 1.16-3.52), while that of s4 vs non-ł4 in APOE4 gene was 5.19 (95% CI = 2.68-10.1). The odds ratio for APOEP4 and FGF1 GG carriers was 20.5 (95% CI = 6.88-60.9). The results showed that the FGF1 gene is associated with autopsy-confirmed AD.
Yamagata
Hidehisa
H
Department of Medical Genetics, Ehime University School of Medicine, Ehime, Japan. hideyama@m.chime-u.ac.jp
Chen
Yusen
Y
Akatsu
Hiroyasu
H
Kamino
Kouzin
K
Ito
Jin-ichi
J
Yokoyama
Shinji
S
Yamamoto
Takayuki
T
Kosaka
Kenji
K
Miki
Tetsuro
T
Kondo
Ikuko
I
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D001344:Autopsy; D016220:Fibroblast Growth Factor 1 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
D001057:Apolipoproteins E; D016220:Fibroblast Growth Factor 1