[Correlation of the changes of T lymphocyte phenotype to tumor stage and operative pattern of gastric cancer].
OBJECTIVE
Immunity, especially cellular immunity, of patients with tumor is related to tumorigenesis. The correlation of changes of T Lymphocyte phenotype to tumor stage and operative pattern of gastric cancer is unclear. This study was to evaluate the perioperative immune state in patients with gastric cancer (GC) of different stage and accepted different operative pattern.


METHODS
Six kinds of T lymphocyte phenotype in 33 GC patients were measured by flow cytometry before and after operation, and compared with that of benign disease patients.


RESULTS
With progress of cancer stage, CD3, CD4, CD4/CD8, CD16, and CD69 gradually decreased, while CD8 gradually increased (P< 0.05). There was no significant difference of activated T cell CD3+/HLA-DR+ among patients of stage I,II,III. After radical resection, CD8 decreased, while CD3, CD4, CD4/CD8, CD16, CD69, and CD3+/HLA-DR+ increased significantly (P< 0.01). CD3, and CD4 unchanged after palliative operation. CD16, and CD4/CD8 further decreased in patients with unresectable tumor (P< 0.05).


CONCLUSIONS
The preoperative immune state of GC patients is negatively related to cancer stage. Tumor removal may improve the cellular immunity of patients.
Wang
Yi-Xin
YX
Department of General Surgery. Putuo Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, PR China. wyixin196612@sohu.com
Su
Wen-Li
WL
Zhu
Wen-Xian
WX
D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000097:blood; D017252:CD3 Complex / Q000097:blood; D016516:CD4-CD8 Ratio; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D007111:Immunity, Cellular; D007432:Intraoperative Period; D037181:Lectins, C-Type; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010641:Phenotype; D017452:Receptors, IgG / Q000097:blood; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D013601:T-Lymphocytes / Q000473:pathology*; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D037181:Lectins, C-Type; D017452:Receptors, IgG; D000099192:CD69 Antigens