Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.
Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcomes. This review will focus on how FABPs direct lipid traffic and simultaneously control inflammatory and metabolic pathways under the pressures of the Metabolic Syndrome.
Makowski
Liza
L
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA.
Hotamisligil
Gökhan S
GS
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D050556:Fatty Acid-Binding Proteins; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D050356:Lipid Metabolism; D024821:Metabolic Syndrome / Q000378:metabolism*
D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins