Maternal anaphylaxis and fetal brain damage after intrapartum chemoprophylaxis.
We report a case of maternal anaphylaxis following intrapartum chemoprophylaxis. The term fetus developed severe brain damage as a consequence of intrapartum asphyxia. The lesions resulted from maternal hypotension following anaphylaxis. We discuss the feto-maternal risks and the controversial treatment of such a condition. The increasing number of penicillin-treated parturients will result in further cases of maternal anaphylaxis than previously found.
Berardi
Alberto
A
Neonatal Intensive Care Unit, Azienda Policlinico, Modena, Italy. berardi.a@policlinico.mo.it
Rossi
Katia
K
Cavalleri
Francesca
F
Simoni
Angela
A
Aguzzoli
Lorenzo
L
Masellis
Giuseppe
G
Ferrari
Fabrizio
F
D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000009:adverse effects*; D000707:Anaphylaxis / Q000139:chemically induced*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000209:etiology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014463:Ultrasonography
D000900:Anti-Bacterial Agents; D000667:Ampicillin