The space of senses: impaired crossmodal interactions in a patient with Balint syndrome after bilateral parietal damage.
Balint syndrome after bilateral parietal damage involves a severe disturbance of space representation including impaired oculomotor behaviour, optic ataxia, and simultanagnosia. Binding of object features into a unique spatial representation can also be impaired. We report a patient with bilateral parietal lesions and Balint syndrome, showing severe spatial deficits in several visual tasks predominantly affecting the left hemispace. In particular, we tested whether a loss of spatial representation would affect crossmodal interactions between simultaneous visual and tactile events occurring at the same versus different locations. A tactile discrimination task, where spatially congruent or incongruent visual cues were delivered near the patient's hands, was used. Following stimulation of the left hand in the left side of space, we observed visuo-tactile interactions that were not modulated by spatially congruent conditions. In contrast, performance following stimulation of the right hand in the right side of space was affected in a spatially selective manner--facilitated for congruent stimuli and slowed for incongruent stimuli. To dissociate effects on somatotopic and spatiotopic coordinates, we crossed the patient's hands during unimodal tactile discriminations. Tactile performance of the left hand improved when it was positioned in the right hemispace, whereas placing the right hand in left space produced no significant changes, suggesting that left-sided tactile inputs are coded with respect to a combination of limb- and trunk-centred coordinates. These data converge with recent findings in animals and healthy humans to indicate a critical role of the posterior parietal cortex in multimodal spatial integration, and in the fusion of different coordinates into a unified representation of space.
Valenza
Nathalie
N
Laboratory of Neurology and Imaging of Cognition, Department of Neuroscience and Clinic of Neurology, University of Geneva, 24 rue Micheli-du-Crest 1211 Geneva 4, Switzerland.
Murray
Micah M
MM
Ptak
Radek
R
Vuilleumier
Patrik
P
D000704:Analysis of Variance; D001259:Ataxia / Q000503:physiopathology; D001927:Brain Diseases / Q000503:physiopathology*; D004192:Discrimination, Psychological / Q000502:physiology; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000293:injuries* / Q000473:pathology; D010468:Perceptual Disorders / Q000503:physiopathology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D013577:Syndrome