Synthesis of dimeric acridine derived antivirals.
A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by >8 logarithmic decades.
Csuk
René
R
Institut f. Organ. Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de
Barthel
Alexander
A
Brezesinski
Torsten
T
Raschke
Christian
C
D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D019281:Dimerization; D017909:Levivirus / Q000187:drug effects
D000166:Acridines; D000998:Antiviral Agents; D001205:Ascorbic Acid