title: Uterine smooth-muscle tumor of uncertain malignant potential metastasizing to the humerus as a high-grade leiomyosarcoma.
abstract: BACKGROUND
  Smooth-muscle tumors of uncertain malignant potential represent a variant of uterine leiomyoma and remain a dilemma due to their uncertain clinical behavior. Most of these tumors have a benign clinical course, and coagulative tumor cell necrosis has usually been associated with worse outcome.
  
  
  METHODS
  We present a case of a uterine smooth-muscle tumor (SMT) of uncertain malignant potential without coagulative tumor cell necrosis that has metastasized to the humerus. The metastatic lesion was a high-grade leiomyosarcoma consistent with uterine origin.
  
  
  CONCLUSIONS
  Smooth-muscle tumors of uncertain malignant potential that demonstrate a lack of coagulative tumor cell necrosis do not necessarily insure benign clinical outcome. These lesions can recur and metastasize to distant sites, thus requiring long-term follow-up.
authors.affiliation: Division of Gynecologic Oncology, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2. adam.shapiro1@mail.mcgill.ca
authors.forename: Adam
authors.initials: A
authors.lastname: Shapiro
authors.forename: Alex
authors.initials: A
authors.lastname: Ferenczy
authors.forename: Robert
authors.initials: R
authors.lastname: Turcotte
authors.forename: Ilan
authors.initials: I
authors.lastname: Bruchim
authors.forename: Walter H
authors.initials: WH
authors.lastname: Gotlieb
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D006811:Humerus / Q000473:pathology; D007889:Leiomyoma / Q000473:pathology*; D007890:Leiomyosarcoma / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery