[Effects of ulinastatin on renal ultrastructure after ischemia-reperfusion in rats].
OBJECTIVE
To investigate the effect of ulinastatin on renal function and ultrastructure changes after renal ischemia-reperfusion in rats.


METHODS
Acute ischemic renal injury model was established (45 min of bilateral renal ischemia and reperfusion for 24 h). Thirty Male SD rats were randomly divided into 3 groups: sham operation group (control group or group C, without renal ischemia), renal ischemia-reperfusion group (ischemia-reperfusion group or group I, without ulinastatin), renal ischemia-reperfusion and ulinastatin intravenous injection group (ulinastatin group or group U). BUN level, serum creatinine values and renal ultrastructure were measured.


RESULTS
Serum creatinine (167 +/- 39) micromol/L and BUN concentration (21 +/- 7) mmol/L in group I were significantly higher than those in group U: serum creatinine (116 +/- 13) micromol/L and BUN concentration (14.1 +/- 2.6) mmol/L (P < 0.05). The renal ultrastructure was greatly injured in group I, meanwhile, it was obviously ameliorated in group U.


CONCLUSIONS
Ulinastatin greatly improved renal function and provides remarkable protection on renal ultrastructure after ischemia-reperfusion of kidney in rats.
Chen
Cong-cong
CC
Department of Anesthesiology, Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, China.
Zhou
Yan
Y
Liu
Zi-ming
ZM
Sun
Ju-mei
JM
Wang
Hui-hua
HH
Wu
Wei-dong
WD
D000818:Animals; D006023:Glycoproteins / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology
D006023:Glycoproteins; C028665:urinastatin