title: Strength retention of drawn self-reinforced polyglycolide rods and fixation properties of the distal femoral osteotomies with these rods. An experimental study on rats.
abstract: Drawn self-reinforced polyglycolide (SR-PGA) rods, Ø 2 mm and 26 mm long, were implanted in the dorsal subcutaneus tissue of 16 rats. Osteotomies of the distal femur were fixed with SR-PGA rods (2 mm by 15 mm) in another 38 rats. The follow-up times varied from one week to one year. After sacrifice, three-point bending and shear tests were performed for subcutaneously placed rods. Radiological, histological, histomorphometrical, microradiographic, and oxytetracycline-fluorescence studies of osteotomized and intact control femora were also performed. At three weeks the flexural strength of the rods was 50% of the initial value, and the flexural modulus was 46% of the initial value. Five osteotomy specimens had to be excluded due to dislocation or non-union. One of the 33 evaluated osteotomy specimens showed signs of postoperative infection. Thirty-two osteotomies healed uneventfully. No gross signs of inflammatory or foreign-body reaction were observed. The amount of osteoid surface and active osteoid formation surface reached their highest value in the histomorphometrical analysis at 24 weeks. The present investigation demonstrated that the mechanical strength and fixation properties of the drawn SR-PGA rods are suitable for fixation of cancellous bone osteotomies in rats. The present article is the first report on the successful application of drawn SR-PGA rods for fixation of cancellous bone osteotomies.
authors.affiliation: Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Topeliuksenkatu 5, FIN-00260 Helsinki, Finland.
authors.forename: Harri
authors.initials: H
authors.lastname: Pihlajamäki
authors.forename: E Antero
authors.initials: EA
authors.lastname: Mäkelä
authors.forename: Nureddin
authors.initials: N
authors.lastname: Ashammakhi
authors.forename: Janne
authors.initials: J
authors.lastname: Viljanen
authors.forename: Hannu
authors.initials: H
authors.lastname: Pätiälä
authors.forename: Pentti
authors.initials: P
authors.lastname: Rokkanen
authors.forename: Timo
authors.initials: T
authors.lastname: Pohjonen
authors.forename: Pertti
authors.initials: P
authors.lastname: Törmälä
authors.forename: Antti
authors.initials: A
authors.lastname: Joukainen