[Transformations of enzyme-active zones in neuromuscular synapses of some skeletal muscles of different origin during postnatal ontogenesis].
The aim of this study was to detect the age-dependent transformations of the enzyme-active zones (EAZ) in neuromuscular synapses (NMSs) of skeletal muscles of different origin. As the objects of study, m. triceps brachii, m. rectus dorsalis oculi, m. sternocleidomastoideus and m. pectoralis major were used, that were taken from the rats aged 3 and 21 days, 1, 3 and 6 months, 1, 1,5 and 2 years. The histochemical method modified by Nikolayev and Shilkin (1983) was used. It was demonstrated that starting from the moment of birth and up to the 1st month of life EAZ in NMSs are mainly represented by simple homogeneous structures. From 1st to 6th month the region of NMS acquired the features which were peculiar to particular muscle. After 6 months and up to 2 years, natural age-related degenerative and regenerative processes were observed in a muscle. The transformations of NMS region in the muscles of varoius origin appeared at different time.
Sabel'nikov
N E
NE
Milekhina
N V
NV
Shamshurina
I V
IV
D000110:Acetylcholinesterase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D066298:In Vitro Techniques; D018482:Muscle, Skeletal / Q000201:enzymology / Q000254:growth & development / Q000294:innervation; D009469:Neuromuscular Junction / Q000201:enzymology* / Q000254:growth & development; D051381:Rats; D013569:Synapses / Q000201:enzymology*
D000110:Acetylcholinesterase