title: Simultaneous detection of alpha-thalassemia and beta-thalassemia by oligonucleotide microarray.
abstract: In this study, we describe a reliable microarray-based assay for the simultaneous detection of alpha/beta-globin genotypes. The efficiency and specificity of this method were evaluated by blinded analysis of 1,880 samples. The assay provides unambiguous detection of complex combinations of heterozygous, compound heterozygous and homozygous alpha/beta-thalassemia genotypes.
authors.forename: Ye
authors.initials: Y
authors.lastname: Bang-Ce
authors.forename: Liu
authors.initials: L
authors.lastname: Hongqiong
authors.forename: Zhang
authors.initials: Z
authors.lastname: Zhuanfong
authors.forename: Lei
authors.initials: L
authors.lastname: Zhengsong
authors.forename: Gao
authors.initials: G
authors.lastname: Jianling
mesh_terms: D001483:Base Sequence; D003937:Diagnosis, Differential; D005838:Genotype; D005914:Globins / Q000235:genetics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D016133:Polymerase Chain Reaction; D017085:alpha-Thalassemia / Q000175:diagnosis* / Q000235:genetics*; D017086:beta-Thalassemia / Q000175:diagnosis* / Q000235:genetics*
chemical_list: D005914:Globins