title: Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections.
abstract: The inflammatory response to chronic infections such as periodontitis may be central to the systemic implications of these diseases. This study examined the possible association between specific gene polymorphisms and the systemic inflammatory response in individuals suffering from severe generalized periodontitis. Ninety-four subjects with periodontitis were genotyped for polymorphisms in IL-1A (-889), IL-1B (-511, +3954), TNF-A (-308), IL-6 (-174) and TLR4 (-299, -399) genes. We found that the genotypes for IL-1A or IL-6 are associated with higher levels of serum IL-6 (P < 0.03) and serum CRP (P < 0.05), similarly the TNF-A genotype is associated with higher levels of serum IL-6 (P < 0.05) after correction for age, body mass index, gender, ethnicity and cigarette smoking. Systemic inflammatory responses are higher in severe periodontitis patients carrying rare alleles for functional inflammatory gene polymorphisms. These results suggest that cytokine genotypes are important determinants of the systemic inflammatory response in subjects with periodontitis. Genetic polymorphism therefore, may in part explain the reported association between periodontitis and systemic disease.
authors.affiliation: Department of Periodontology, Eastman Dental Institute and Hospital, University College London, UK.
authors.forename: F
authors.initials: F
authors.lastname: D'Aiuto
authors.forename: M
authors.initials: M
authors.lastname: Parkar
authors.forename: P M
authors.initials: PM
authors.lastname: Brett
authors.forename: D
authors.initials: D
authors.lastname: Ready
authors.forename: M S
authors.initials: MS
authors.lastname: Tonetti
mesh_terms: D001483:Base Sequence; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000235:genetics*; D017931:DNA Primers; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000235:genetics / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000276:immunology*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D012907:Smoking
chemical_list: D015415:Biomarkers; D016207:Cytokines; D017931:DNA Primers; D015850:Interleukin-6; D007378:Interleukins; D002097:C-Reactive Protein