title: Polymeric active coatings with functionality in vascular applications.
abstract: Copolymers containing functional groups with activity as antiaggregating agents for platelets, based on random chains of metacryloyloxyethyl [2-(acetyloxy)-4-(trifluoromethyl)]benzoate, TH, and 2-acrylamido-2-metylpropanesulfonic acid, AMPS, with AMPS molar fractions ranging from 0.1 to 0.4, have been prepared. The spectroscopical characterization and the in vitro swelling behavior have been studied, as well as the surface free energy, showing the copolymers an appropriate surface properties from a haemocompatible point of view. Preliminary in vitro tests using human blood have shown a promising antiaggregating behavior.
authors.affiliation: Instituto de Ciencia y Tecnología de Polímeros, CSIC, Juan de la Cierva 3, 28006, Madrid, Spain.
authors.forename: María Rosa
authors.initials: MR
authors.lastname: Aguilar
authors.forename: Gema
authors.initials: G
authors.lastname: Rodríguez
authors.forename: Mar
authors.initials: M
authors.lastname: Fernández
authors.forename: Alberto
authors.initials: A
authors.lastname: Gallardo
authors.forename: Julio
authors.initials: J
authors.lastname: San Román