Feasibility of a two-metal, four-purine nucleobase quartet motif.
A mixed-purine nucleobase complex of composition trans-[(NH(3))(2)Pt(9-EtA-N1)(9-MeHx-N7)](NO(3))(2).2H(2)O (1) (9-EtA = 9-ethyladenine; 9-MeHx = 9-methylhypoxanthine) has been prepared and characterized by X-ray crystallography. Cations of 1 are self-complementary as far as hydrogen bonding properties are concerned and form H bonded dimers, containing four intermolecular hydrogen bonds in addition to two intramolecular ones. The resulting mixed-purine square is considered a model compound for a putative mixed-purine tetrad consisting of two adenines and two guanines. In this model, the one-metal, four-nucleobase quartet motif, as seen in guanine or uracil quartets of nucleic acids, with the metal located in the center of the base tetrad, has been altered to a two-metal, four-nucleobase motif, with the two metal ions localized at the periphery.
Roitzsch
Michael
M
Fachbereich Chemie, Universität Dortmund, 44221 Dortmund, Germany.
Lippert
Bernhard
B
D020029:Base Pairing; D018360:Crystallography, X-Ray; D005240:Feasibility Studies; D006860:Hydrogen Bonding; D008956:Models, Chemical; D008968:Molecular Conformation; D009944:Organoplatinum Compounds / Q000138:chemical synthesis*; D010984:Platinum / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*
D009944:Organoplatinum Compounds; D011687:Purines; D010984:Platinum