title: Congenital cardiac disease as a core feature of cranio-osteoarthropathy.
abstract: Cranio-osteoarthropathy is a rare condition. Classically, signs are identifiable in infancy with clubbing of fingers, and delayed closure of the clinically enlarged cranial sutures, followed by periosteal new bone formation on X-rays of the long bones. Ultimately, joint swelling and stiffness follow, typically involving the large joints. We report two unrelated patients with features of cranio-osteoarthropathy, both of whom also had a history of congenital heart disease. Moreover, the cases reported here, manifesting significant differences in radiological features, emphasize the variability of radiological findings which can attend this condition.
authors.affiliation: Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland Clinical Genetic Service, City Hospital, Nottingham, UK Great Ormond Street Hospital for Children, London, UK.
authors.forename: Susan
authors.initials: S
authors.lastname: O'Connell
authors.forename: Mohnish
authors.initials: M
authors.lastname: Suri
authors.forename: Desmond
authors.initials: D
authors.lastname: Duff
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Kelleher
authors.forename: Christine M
authors.initials: CM
authors.lastname: Hall
authors.forename: William
authors.initials: W
authors.lastname: Reardon
mesh_terms: D000842:Ankle / Q000002:abnormalities; D001842:Bone and Bones / Q000002:abnormalities*; D002675:Child, Preschool; D005260:Female; D005385:Fingers / Q000002:abnormalities / Q000000981:diagnostic imaging; D006331:Heart Diseases / Q000503:physiopathology*; D006801:Humans; D007717:Knee / Q000002:abnormalities; D007866:Leg / Q000002:abnormalities / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging; D013577:Syndrome