title: Synthesis of chiral amino epoxyaziridines: useful intermediates for the preparation of chiral trisubstituted piperidines.
abstract: Chiral aminoalkyl epoxyaziridine 1 is synthesized in high yield and diastereoselectivity from L-serine. Ring opening of epoxyaziridine 1 with primary amines is carried out with total chemo- and regioselectivity, affording chiral polyfunctionalized piperidines 8. The structure of these trisubstituted piperidines is established by NMR studies.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain. jmcg@sauron.quimica.uniovi.es
authors.forename: José M
authors.initials: JM
authors.lastname: Concellón
authors.forename: Estela
authors.initials: E
authors.lastname: Riego
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Rivero
authors.forename: Adrián
authors.initials: A
authors.lastname: Ochoa