title: [Intramuscular application of diclofenac--case report and critical consideration of a therapeutic measure].
abstract: Diclofenac is a non-steroidal anti-inflammatory drug of the phenylacetic class. It is frequently given as an intramuscular injection. However several, sometimes severe, side effects have been described after an i.m. administration. Based on a short case report about a fatal complication in the context of the i.m. administration of diclofenac, the arguments for and against the intramuscular injection of the drug are critically discussed. As a result, the administration of diclofenac as an intramuscular injection should be critically reviewed and alternatives -- as suppositories are available -- should be taken into account.
authors.affiliation: Institut für Rechtsmedizin, Klinikum der Universität zu Köln. hildegard.grass@uk-koeln.de
authors.forename: H
authors.initials: H
authors.lastname: Grass
authors.forename: A
authors.initials: A
authors.lastname: Schuff
authors.forename: C
authors.initials: C
authors.lastname: Bertram
authors.forename: M A
authors.initials: MA
authors.lastname: Rothschild
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D020968:Brachial Plexus Neuritis / Q000188:drug therapy* / Q000401:mortality*; D004008:Diclofenac / Q000008:administration & dosage* / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects*; D010346:Patient Care Management / Q000379:methods; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac