title: P marks the spot: site-specific integrin phosphorylation regulates molecular interactions.
abstract: Integrins are heterodimeric adhesion receptors at the cell membrane that function as two-way signaling devices. The short intracellular tails of integrins are devoid of catalytic activity, but are nevertheless important for adhesion and signaling, presumably, through interactions with cytoplasmic molecules. Recently, the structure of the intracellular tails has been investigated using NMR, giving important new insight into how integrins might be regulated, but many questions remain unanswered. Signaling by many cell-surface receptors involves protein phosphorylation; over the past few years, phosphorylation of the integrin tails at specific sites has started to emerge as a dynamic mechanism that regulates molecular interactions between integrins and cytoplasmic molecules. This phosphorylation might give rise to signaling specificity and fine-tuning of the integrin-mediated responses.
authors.affiliation: Division of Biochemistry, Faculty of Biosciences, PB 56 (Viikinkaari 5), 00014 University of Helsinki, Finland. susanna.fagerholm@helsinki.fi
authors.forename: Susanna C
authors.initials: SC
authors.lastname: Fagerholm
authors.forename: Tiina J
authors.initials: TJ
authors.lastname: Hilden
authors.forename: Carl G
authors.initials: CG
authors.lastname: Gahmberg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D016023:Integrins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011487:Protein Conformation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016023:Integrins