Validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone.
Two simple, sensitive and economical spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in pure form and commercial dosage form. These methods (A and B) are based on the reaction of amiodarone base as n-electron donor with p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as pi-acceptors to give highly colored complex species which absorb maximally at 535 and 570 nm, respectively. Beer's law is obeyed in the concentration ranges 10.0 - 360.0 and 2.0 - 65.0 microg ml(-1) for methods A and B, respectively. Application of the proposed methods to commercial pharmaceutical tablets are presented.
Rahman
Nafisur
N
Department of Chemistry, Aligarh Muslim University, Aligarh-202002 UP, India. cht17nr@yahoo.co.in
Khan
Nadeem Ahmad
NA
Azmi
Syed Najmul Hejaz
SN
D000638:Amiodarone / Q000032:analysis* / Q000737:chemistry; D000889:Anti-Arrhythmia Agents / Q000032:analysis* / Q000737:chemistry; D016227:Benzoquinones / Q000737:chemistry*; D002138:Calibration; D004304:Dosage Forms; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods
D000889:Anti-Arrhythmia Agents; D016227:Benzoquinones; D004304:Dosage Forms; C000928:dichlorodicyanobenzoquinone; D000638:Amiodarone; C014400:chloranilic acid