[Atorvastatin: lipid lowering activity, pleiotropic properties and efficacy in prevention of atherosclerosis and coronary heart disease].
The review presents data on pharmacological properties of atorvastatin, its lipid lowering activity, and action on main mechanisms of atherogenesis. Favorable pleiotropic effects of atorvastatin such as normalization of endothelial function, antiinflammatory, antithrombotic and antioxidant activity contribute to stabilization of atheromatous plaques. Clinical trials revealing early and significant effects of the drug on main end points have demonstrated its high value for primary and secondary prevention of atherosclerosis.
Bubnova
M G
MG
Research Center for Preventive Medicine; Petroverigsky per., 10, 101953 Moscow, Russia.
D050197:Atherosclerosis / Q000188:drug therapy; D000069059:Atorvastatin; D003324:Coronary Artery Disease / Q000188:drug therapy; D006538:Heptanoic Acids / Q000494:pharmacology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D011758:Pyrroles / Q000494:pharmacology
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin