title: Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp.
abstract: The structure of a new dibenzodiazepine alkaloid, diazepinomicin (1), isolated from the culture of a marine actinomycete of the genus Micromonospora was characterized using spectroscopic methods. Diazepinomicin represents a unique molecular class composed of a dibenzodiazepine core linked to a farnesyl side chain.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. charanr@wyeth.com
authors.forename: Romila D
authors.initials: RD
authors.lastname: Charan
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schlingmann
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Janso
authors.forename: Valerie
authors.initials: V
authors.lastname: Bernan
authors.forename: Xidong
authors.initials: X
authors.lastname: Feng
authors.forename: Guy T
authors.initials: GT
authors.lastname: Carter
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003984:Dibenzazepines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007564:Japan; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D003984:Dibenzazepines; C492422:diazepinomicin