Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1.
Hepatitis C virus (HCV) quasispeciation was studied in two children vertically coinfected with HCV and human immunodeficiency virus type 1 (HIV-1). HCV quasispecies diversification and liver injury were more significant in patient C1, who was immunocompetent with anti-HIV therapy, than in patient C2, who was immunosuppressed, in consistency with modulation of HCV quasispeciation and liver injury by immunocompetence in coinfected children.
Canobio
Sophie
S
Unité d'immunopathologie virale, Centre de recherche de l'Hôpital Sainte-Justine, 3175 Côte Sainte-Catherine, Room 6735, Montréal (Québec) H3T 1C5, Canada.
Guilbert
Cynthia M
CM
Troesch
Myriam
M
Samson
Johanne
J
Lemay
Mireille
M
Pelletier
Veronique Anne
VA
Bernard-Bonnin
Anne-Claude
AC
Kozielski
Rafal
R
Lapointe
Normand
N
Martin
Steven R
SR
Soudeyns
Hugo
H
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000635:transmission; D023241:Antiretroviral Therapy, Highly Active; D002648:Child; D018450:Disease Progression; D005260:Female; D016174:Hepacivirus / Q000145:classification*; D006526:Hepatitis C / Q000150:complications / Q000473:pathology* / Q000635:transmission; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008099:Liver / Q000473:pathology; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology