title: Penasulfate A, a new alpha-glucosidase inhibitor from a marine sponge Penares sp.
abstract: A new alpha-glucosidase inhibitor, penasulfate A, has been isolated from a marine sponge Penares sp.(1) Its structure was elucidated by spectral and chemical methods to be a scalemic mixture of methyl pipecolates acylated with a novel sulfated fatty acid.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Takashi
authors.initials: T
authors.lastname: Maki
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010875:Pipecolic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D005227:Fatty Acids; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010875:Pipecolic Acids; C492413:penasulfate A