Nanosizing drug particles in supercritical fluid processing.
The supercritical fluid-processing technique, rapid expansion of a supercritical solution into a liquid solvent (RESOLV), was applied to the nanosizing of water-insoluble drug particles. Selected for demonstration were antiinflammatory drugs Ibuprofen and Naproxen, for which CO2 and CO2-cosolvent systems were used. The RESOLV process produces exclusively nanoscale (less than 100 nm) Ibuprofen and Naproxen particles suspended in aqueous solutions, and the aqueous suspensions of the drug nanoparticles are protected from particle agglomeration and precipitation by using common polymeric and oligomeric stabilization agents.
Pathak
Pankaj
P
Department of Chemistry, Howard L. Hunter Chemistry Laboratory, Clemson University, Clemson, SC 29634-0973, USA.
Meziani
Mohammed J
MJ
Desai
Tarang
T
Sun
Ya-Ping
YP
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009288:Naproxen / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen; D007052:Ibuprofen