Titanium catalysis in the Ugi reaction of alpha-amino acids with aromatic aldehydes.
[reaction: see text] Ugi reaction between an (S)-alpha-amino acid, an aromatic aldehyde, and an isonitrile proceeds best under catalysis by TiCl(4) in MeOH. The sense of diastereoinduction is (S,S).
Godet
Thomas
T
Laboratoire de Synthèse et Méthodologie Organiques, CNRS UMR 5181, and Centre Commun de Diffractométrie, Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique et Electronique de Lyon, 69622 Villeurbanne, France.
Bonvin
Yannick
Y
Vincent
Guillaume
G
Merle
Daphné
D
Thozet
Alain
A
Ciufolini
Marco A
MA
D000447:Aldehydes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D000447:Aldehydes; D000596:Amino Acids; D017672:Nitrogen Compounds; D014025:Titanium