title: Vitiligo as a paraneoplastic syndrome preceding pituitary adenoma and subsequent acute lymphoblastic leukemia.
abstract: We present an unusual case of rapid onset of vitiligo heralding blindness due to pituitary apoplexy secondary to a non-secreting pituitary adenoma in a 49-year-old man. Deterioration in vision and skin condition coincided with tumor progression over 3 years. He subsequently died of acute lymphoblastic leukemia after pituitary radiation. The possible pathological associations between the 2 malignancies and vitiligo are discussed.
authors.affiliation: Department of Medicine, Queen Mary Hospital, Hong Kong. auwing@hotmail.com
authors.forename: Wing Y
authors.initials: WY
authors.lastname: Au
authors.forename: Charmaine
authors.initials: C
authors.lastname: Hon
authors.forename: Alex C L
authors.initials: AC
authors.lastname: Chan
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sano
authors.forename: Henry H
authors.initials: HH
authors.lastname: Chan
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis*; D001766:Blindness / Q000175:diagnosis / Q000209:etiology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000209:etiology; D014820:Vitiligo / Q000175:diagnosis* / Q000209:etiology