title: Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells.
abstract: The cytotoxicity of two plant hormone compounds, kinetin and kinetin riboside, was studied on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The concentration of inhibitor required to reduce cell growth to 50% was determined for these molecules. Kinetin riboside was shown to only act on M4 Beu human and B16 murine melanoma cells at low concentration (1.5 and 0.2 microM). On mice with leukaemia P388, this product has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg. Kinetin riboside was also shown to have a cytotoxic effect on plant tumour cells (crown-gall).
authors.affiliation: EA 3296 ERTAC, Physiologie et Génétique Végétales, Université Blaise-Pascal, 24 avenue des Landais, 63177 Aubière Cedex, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Griffaut
authors.forename: Romain
authors.initials: R
authors.lastname: Bos
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Maurizis
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Madelmont
authors.forename: Gérard
authors.initials: G
authors.lastname: Ledoigt
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D007701:Kinetin; D008297:Male; D008546:Melanoma, Experimental; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D009705:Nucleosides / Q000494:pharmacology*; D010937:Plant Growth Regulators / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009705:Nucleosides; D010937:Plant Growth Regulators; D000225:Adenine; D007701:Kinetin