title: Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease.
abstract: Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (> or =130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD.
authors.affiliation: Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Timmermann
authors.forename: Lars
authors.initials: L
authors.lastname: Wojtecki
authors.forename: Joachim
authors.initials: J
authors.lastname: Gross
authors.forename: Ralph
authors.initials: R
authors.lastname: Lehrke
authors.forename: Jürgen
authors.initials: J
authors.lastname: Voges
authors.forename: Mohammed
authors.initials: M
authors.lastname: Maarouf
authors.forename: Harald
authors.initials: H
authors.lastname: Treuer
authors.forename: Volker
authors.initials: V
authors.lastname: Sturm
authors.forename: Alfons
authors.initials: A
authors.lastname: Schnitzler
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D004292:Dominance, Cerebral / Q000502:physiology; D004359:Drug Therapy, Combination; D004553:Electric Conductivity; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009415:Nerve Net / Q000503:physiopathology; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D025321:Surgery, Computer-Assisted; D017211:Treatment Failure; D014202:Tremor / Q000503:physiopathology / Q000628:therapy
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa