Sequential transfer of left-right information during vertebrate embryo development.
The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-beta superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.
Raya
Angel
A
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, California 92037, USA.
Izpisúa Belmonte
Juan Carlos
JC
D000818:Animals; D019521:Body Patterning; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D055457:Nodal Protein; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D014714:Vertebrates / Q000196:embryology* / Q000378:metabolism*
C526007:NODAL protein, human; D055457:Nodal Protein; D016212:Transforming Growth Factor beta