N-heterocyclic carbenes: reagents, not just ligands!
The unique properties of N-heterocyclic carbenes (NHCs) have attracted much attention, mainly from theorists and organometallic chemists, the latter using them impressively as ligands for metals. Less well known, however, has been their suitability as excellent catalysts and nucleophilic reagents. Transesterification, nucleophilic aromatic substitution, and cycloaddition reactions are examples in which NHCs can play an important role. Asymmetric reactions using catalytic amounts of chiral NHCs are an efficient approach to optically active compounds. This minireview focuses on this aspect of the chemistry of NHCs.
Nair
Vijay
V
Organic Chemistry Division, Regional Research Laboratory (CSIR), Trivandrum 695 019, India. vijaynair_2001@yahoo.com
Bindu
Santhamma
S
Sreekumar
Vellalath
V