title: Local control after supracricoid partial laryngectomy for "advanced" endolaryngeal squamous cell carcinoma classified as T3.
abstract: OBJECTIVE
  To determine the incidence of local control in patients with "advanced" moderately to well-differentiated endolaryngeal invasive squamous cell carcinoma classified as T3, treated with a supracricoid partial laryngectomy; to identify any statistical relationship; and to analyze the consequences of local recurrence.
  
  
  METHODS
  Retrospective nonrandomized case series.
  
  
  METHODS
  A tertiary referral care center and university teaching hospital.
  
  
  METHODS
  An inception cohort of 118 patients. Tumor stage was T3 N0 M0 in 90 patients, T3 N1 M0 in 21 patients, T3 N2 M0 in 5 patients, and T3 N3 M0 in 2 patients.
  
  
  METHODS
  All patients underwent supracricoid partial laryngectomy. A platin-based induction chemotherapy regimen was used in 100 patients. Postoperative radiotherapy was used for 24 patients.
  
  
  METHODS
  Local recurrence, nodal recurrence, distant metastasis, and survival; univariate and multivariate analysis of local recurrence.
  
  
  RESULTS
  Nine patients developed a local recurrence. The 1-, 3-, and 5-year actuarial local control estimates were 97.3%, 93.5%, and 91.4%, respectively. In a stepwise regression model, the presence of positive margins of resection was the only variable that statistically increased the risk of local recurrence (P =.008). Local recurrence resulted in a significant increase in nodal recurrence (P<.001) and distant metastasis (P<.001) and a significant decrease in survival (P =.03). An overall 89.8% laryngeal preservation rate and 98.3% local control rate were achieved.
  
  
  CONCLUSIONS
  Supracricoid partial laryngectomies should be considered when an organ preservation strategy is discussed in patients with advanced endolaryngeal squamous cell carcinoma classified as T3.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, University of Paris V, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Dufour
authors.forename: Stéphane
authors.initials: S
authors.lastname: Hans
authors.forename: Erwan
authors.initials: E
authors.lastname: De Mones
authors.forename: Daniel
authors.initials: D
authors.lastname: Brasnu
authors.forename: Madeleine
authors.initials: M
authors.lastname: Ménard
authors.forename: Ollivier
authors.initials: O
authors.lastname: Laccourreye
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012044:Regression Analysis; D012189:Retrospective Studies; D015996:Survival Rate