title: Heterochromatin: RNA points the way.
abstract: Mutation of the multi-KH domain protein DPP1, which has single-stranded nucleic acid binding activity, suppresses heterochromatin-mediated silencing in Drosophila; it also disrupts the modification of histone H3 at lysine 9, and association of heterochromatin protein 1 on the heterochromatic regions, suggesting a role for DDP1 in heterochromatin formation.
authors.affiliation: Division of Biological Sciences, Tucker Hall, University of Missouri, Columbia, Missouri 65211, USA. BirchlerJ@Missouri.edu
authors.forename: James A
authors.initials: JA
authors.lastname: Birchler
authors.forename: Harsh H
authors.initials: HH
authors.lastname: Kavi
authors.forename: Harvey R
authors.initials: HR
authors.lastname: Fernandez
mesh_terms: D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics* / Q000502:physiology; D020868:Gene Silencing / Q000502:physiology; D006570:Heterochromatin / Q000235:genetics* / Q000502:physiology; D006657:Histones / Q000378:metabolism*; D008745:Methylation; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D034622:RNA Interference
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; C491076:Dp1 protein, Drosophila; D029721:Drosophila Proteins; D006570:Heterochromatin; D006657:Histones; D000090266:Chromobox Protein Homolog 5