Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group.
Paulini
Ralph
R
Laboratorium für Organische Chemie, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
Lerner
Christian
C
Jakob-Roetne
Roland
R
Zürcher
Gerhard
G
Borroni
Edilio
E
Diederich
François
F
D002394:Catechol O-Methyltransferase / Q000737:chemistry; D065098:Catechol O-Methyltransferase Inhibitors; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007202:Indicators and Reagents; D008274:Magnesium / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009574:Nitro Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
D065098:Catechol O-Methyltransferase Inhibitors; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D009574:Nitro Compounds; D002394:Catechol O-Methyltransferase; D008274:Magnesium