Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines.
Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described.
de Fatima
Angelo
A
Instituto de Quimica, Unicamp, CP 6154, 13084-971, Campinas, São Paulo, Brazil.
Kohn
Luciana Konecny
LK
Antônio
Márcia Aparecida
MA
de Carvalho
João Ernesto
JE
Pilli
Ronaldo Aloise
RA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D007783:Lactones; C108954:argentilactone