title: Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival.
abstract: Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regulator of HSC survival. Following inactivation of Tel/Etv6, HSCs are lost in the adult bone marrow but their progeny are unaffected and transiently sustain blood formation. Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes. Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs.
authors.affiliation: Division of Hematology/Oncology, Children's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Hanno
authors.initials: H
authors.lastname: Hock
authors.forename: Eliza
authors.initials: E
authors.lastname: Meade
authors.forename: Sarah
authors.initials: S
authors.lastname: Medeiros
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Schindler
authors.forename: Peter J M
authors.initials: PJ
authors.lastname: Valk
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Stuart H
authors.initials: SH
authors.lastname: Orkin
mesh_terms: D000818:Animals; D001483:Base Sequence; D002470:Cell Survival / Q000502:physiology*; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D017931:DNA Primers; D004268:DNA-Binding Proteins; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D000097764:ETS Translocation Variant 6 Protein