title: Magnetic resonance-defined perinephric edema after clinical islet transplantation: a benign finding associated with mild renal impairment.
abstract: Immunosuppression with sirolimus and low-dose tacrolimus has facilitated successful clinical islet transplantation (CIT). Because the long-term effects on the kidney are unknown and immunosuppressant drugs can be nephrotoxic, CIT is currently restricted to patients with preserved renal function or a functioning renal transplant. The impact of CIT on the native kidney of islet-alone recipients was assessed with magnetic resonance imaging (MRI). After successful CIT, MRI revealed perinephric edema (PNE) in 10 of 30 recipients. PNE was associated with a mild degree of renal impairment but was not associated with preexisting diabetic nephropathy, albuminuria, microscopic hematuria, graft function, or other clinical and metabolic parameters. The presence of PNE on MRI after CIT seems to be a common but benign finding, most likely an adverse effect of sirolimus. Although this novel observation does not seem to be of concern, further studies are required to examine the long-term impact of CIT and immunosuppression on renal function.
authors.affiliation: Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Senior
authors.forename: A M James
authors.initials: AM
authors.lastname: Shapiro
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Ackerman
authors.forename: Edmond A
authors.initials: EA
authors.lastname: Ryan
authors.forename: Breay W
authors.initials: BW
authors.lastname: Paty
authors.forename: Ravi
authors.initials: R
authors.lastname: Bhargava
mesh_terms: D000328:Adult; D004487:Edema / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects*; D007674:Kidney Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome