title: Origin of stellate giant cells in oral fibrous lesions determined by immunohistochemical expression of vimentin, HHF-35, CD68 and factor XIIIa.
abstract: OBJECTIVE
  To determine the origin of mono-, bi- and multinucleate stellate giant cells in giant cell fibroma, fibrous hyperplasia and fibroepithelial polyp of the oral mucosa.
  
  
  METHODS
  Ten cases of each lesion were studied immunohistochemically using anti-vimentin, -HHF-35, -CD68 and -factor XIIIa antibodies. Immunoreactivity of the cells was determined in the papillary and reticular lamina propria of these lesions.
  
  
  RESULTS
  Vimentin positivity in both the papillary and reticular lamina propria was observed for most samples, especially giant cell fibroma cases.
  
  
  CONCLUSIONS
  The immunohistochemical findings of the present study suggest that the mono-, bi- or multinucleate stellate giant cells observed in the lesions studied derived from the fibroblastic lineage.
authors.affiliation: Laboratory of Oral Pathology, Dentistry School, Federal University of Rio Grande do Norte, 1787 CEP-59056-000 Natal, Brazil. leliasouza@dod.ufrn.br
authors.forename: Lélia B
authors.initials: LB
authors.lastname: Souza
authors.forename: Emanuel S S
authors.initials: ES
authors.lastname: Andrade
authors.forename: Márcia C C
authors.initials: MC
authors.lastname: Miguel
authors.forename: Roseana A
authors.initials: RA
authors.lastname: Freitas
authors.forename: Leão P
authors.initials: LP
authors.lastname: Pinto
mesh_terms: D000199:Actins / Q000378:metabolism; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D019070:Cell Lineage; D026122:Factor XIIIa / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology; D005350:Fibroma / Q000378:metabolism* / Q000473:pathology; D015726:Giant Cells / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009059:Mouth Diseases / Q000378:metabolism* / Q000473:pathology; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology*; D011127:Polyps / Q000378:metabolism* / Q000473:pathology; D014746:Vimentin / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D000199:Actins; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D026122:Factor XIIIa; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule