The effect of xylitol on the stability and morphological parameters of tablets with sorbitol made by direct tabletting of formulation components.
Model tablets of polyols (sorbitol and xylitol) comprised 88% by mass, were produced using a direct compression method. Morphological and mechanical parameters of the model tablets were investigated ex tempore as well as after 12 and 24 months' storage. The effect of xylitol on selected morphological parameters of practical relevance during storage was estimated. The results obtained are a basis for further work on the use of polyols (sorbitol, xylitol and other sugar alcohols) in the production of oral forms of drugs, particularly buccal tablets.
Zgoda
M M
MM
Department of Applied Pharmacy, Medical University, Lódź, Poland.
Woskowicz
M
M
Nachajski
M
M
Haeusler
O
O
Iwanczyk
M
M
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients; D006244:Hardness; D012995:Solubility; D013012:Sorbitol / Q000737:chemistry*; D013607:Tablets; D014993:Xylitol / Q000737:chemistry*
D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D013012:Sorbitol; D014993:Xylitol