Homology-based modelling of targets for rational drug design.
The current status in rational drug design using homology-based models is discussed, with focus on template selection, model building, model verification and strategies for drug design based on model structures. A novel approach for identification of unique binding site features from homology-based models, Protein Alpha Shape Similarity Analysis (PASSA) is described.
Wieman
Heather
H
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, MTFS, Norwegian University of Science and Technology, N-7489 Trondheim.
Tøndel
Kristin
K
Anderssen
Endre
E
Drabløs
Finn
F
D001665:Binding Sites; D015195:Drug Design; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D017385:Sequence Homology; D013329:Structure-Activity Relationship
D008024:Ligands; D011506:Proteins