Multiple myeloma and renal transplant.
Until now, no case of multiple myeloma (MM) had been reported among the B-lymphoproliferative disorders occurring in organ-transplant recipients. The history of a 58-year-old man who developed IgG-kappa MM 31 months after a cadaveric renal transplant is described. A possible relationship between drug-mediated immunosuppression and the development of MM is discussed.
Cacciola
E
E
Department of Hematology, University of Catania, Ospedale Ferrarotto, Italy.
Giustolisi
R
R
Guglielmo
P
P
Cacciola
E
E
D001379:Azathioprine / Q000009:adverse effects; D016572:Cyclosporine / Q000009:adverse effects; D003586:Cytomegalovirus Infections / Q000150:complications; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology* / Q000276:immunology / Q000821:virology; D009194:Myeloma Proteins / Q000032:analysis; D011241:Prednisone / Q000009:adverse effects
D007145:Immunoglobulin kappa-Chains; D007166:Immunosuppressive Agents; D009194:Myeloma Proteins; D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone