Oxidative stress, caveolae and caveolin-1.
Oxidative stress underlies a range of pathophysiological conditions. Reactive oxygen species are also generated intracellularly to serve as second messengers and some are linked to caveolae/raft signalling systems. The effect of oxidative stress on caveolin-1 expression, post-translational modifications, membrane trafficking and function are described.
Parat
Marie-Odile
MO
Departments of Anesthesiology Research and Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Fox
Paul L
PL
D000818:Animals; D021941:Caveolae / Q000502:physiology* / Q000648:ultrastructure; D051242:Caveolin 1; D022461:Caveolins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
C495540:CAV1 protein, human; D051242:Caveolin 1; D022461:Caveolins; D017382:Reactive Oxygen Species