title: Effect of a dietary supplement combination on weight management, adipose tissue, cholesterol and triglycerides in obese subjects.
abstract: A combination dietary supplement containing vitamins, minerals, herbs, fibers and amino acids was studied to determine its safety and efficacy on weight/ fat loss, cholesterol and triglycerides in a double-blind, placebo-controlled trail. Total body weight, body fat %, waist and hip measurements, total cholesterol and triglycerides were evaluated before and after 6 weeks treatment with combination supplement or placebo. The study population consisted in 27 mildly to moderately obese, otherwise healthy, volunteers. After 6 weeks of treatment, the combination supplement had a statistically significant (p<0.001, mu=0.05) positive weight reducing effect (-8.59Lb vs. +2.14 Lb). This weight reduction was associated with a corresponding statistically significant (p<0.001, mu=0.05) decrease in body fat % in the treatment group (-2.88%) vs. the placebo (+0.86%). In addition, significant decreases in total cholesterol (-22.94 mg/dL) and triglycerides (-39.29 mg/dL) were obtained plus reductions in waist and hip measurements. These positive results lead us to conclude, that the combination supplement studied herein is a safe and effective way to assist in weight/fat reduction and decreases in total cholesterol and triglycerides in relatively short time (6 weeks).
authors.affiliation: InBioMed Project, University of Puerto Rico, Medical Sciences Campus. mgonzalez@rcm.upr.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: González
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Miranda-Massari
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Ricart
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000328:Adult; D000886:Anthropometry; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D019587:Dietary Supplements; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D014280:Triglycerides / Q000097:blood*; D015431:Weight Loss / Q000502:physiology
chemical_list: D019440:Anti-Obesity Agents; D014280:Triglycerides; D002784:Cholesterol