title: Consensus perspectives on surgery in haemophilia patients with inhibitors: summary statement.
abstract: Summary. Participants in an international workshop on surgery in haemophilia patients with inhibitors developed a consensus summary of the findings and conclusions of the meeting. In the consensus, participants agreed upon revised definitions for minor and major surgery, including an intermediate degree of surgery. An evaluation system of intraoperative and postoperative bleeding was developed. Recommended doses of FEIBA((R)) and rFVIIa (both in bolus injections and in continuous infusion) for surgery were agreed. Participants also agreed on the main blood tests to be performed peri-operatively. They also suggested the need of a prospective evaluation in the future. Finally, the approximate number of surgical procedures and costs performed on haemophilia patients with inhibitors were analysed.
authors.affiliation: Service of Traumatology and Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain. rmerchan@arrakis.es
authors.forename: E C
authors.initials: EC
authors.lastname: Rodriguez-Merchan
authors.forename: A
authors.initials: A
authors.lastname: Rocino
authors.forename: B
authors.initials: B
authors.lastname: Ewenstein
authors.forename: L
authors.initials: L
authors.lastname: Bartha
authors.forename: A
authors.initials: A
authors.lastname: Batorova
authors.forename: J
authors.initials: J
authors.lastname: Goudemand
authors.forename: A
authors.initials: A
authors.lastname: Gringeri
authors.forename: M
authors.initials: M
authors.lastname: Joao-Diniz
authors.forename: S
authors.initials: S
authors.lastname: Lopaciuk
authors.forename: C
authors.initials: C
authors.lastname: Negrier
authors.forename: M
authors.initials: M
authors.lastname: Quintana
authors.forename: G
authors.initials: G
authors.lastname: Tagariello
authors.forename: G E
authors.initials: GE
authors.lastname: Tjonnfjord
authors.forename: V A
authors.initials: VA
authors.lastname: Villar
authors.forename: Z
authors.initials: Z
authors.lastname: Vorlova
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D015942:Factor VIIa / Q000627:therapeutic use; D006467:Hemophilia A / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D002836:Hemophilia B / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001779:Blood Coagulation Factors; D011994:Recombinant Proteins; C065655:anti-inhibitor coagulant complex; D015942:Factor VIIa