Voltage-gated potassium channels in cell proliferation.
It is commonly accepted that cells require K(+) channels to proliferate. The role(s) of K(+) channels in the process is, however, poorly understood. Cloning of K(+) channel genes opened the possibility to approach this problem in a way more independent from pharmacological tools. Recent work shows that several identified K(+) channels are important in both physiological and pathological cell proliferation and open a promising pathway for novel targeted therapies.
Pardo
Luis A
LA
Max-Planck Institute for Experimental Medicine, 37075 Göttingen, Germany. lpardo@gwdg.de
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D006801:Humans; D024642:Potassium Channels, Voltage-Gated / Q000502:physiology*
D024642:Potassium Channels, Voltage-Gated