title: [Descriptive study of onset diabetes mellitus type 1 patients and first degree families].
abstract: BACKGROUND
  Few information about descriptive studies of autoimmunity in diabetes mellitus type 1 onset patients and family exist. The aim of our study was to analyze clinical and biochemical parameters of onset diabetes mellitus type 1 patients and first degree families.
  
  
  METHODS
  Forty seven onset diabetes mellitus type 1 patients and 148 first degree families were studied, between January 1999 and December 2002, in the west area of Valladolid. In all cases and families an anthropometric study and biochemical determination with autoimmunity levels were performed.
  
  
  RESULTS
  Average age in onset diabetes mellitus type 1 patients was 16.09 (9.36) years, without differences between males (32 cases, 68%) and females (15 cases, 32%), with an incidence of 4.66 cases/100,000 habs./year. Average values of peroxidase antibodies (antiPTO) and glutamic descarboxilase antibodies (antiGAD) were higher in diabetic patients than in families. No differences were detected in insulin antibodies (IAA) and tiroglobuline antibodies (antiTG). No correlation was detected between anti TPO and anti pancreas. Autoantibodies did not influence in glycemic control. Average dose of NPH insulin and regular insulin were 27.58 (13.88) UI/d y 3.05 (4.90) UI/d, respectively.
  
  
  CONCLUSIONS
  Average age of onset diabetes mellitus type 1 patients was similar than other studies, with a high frequency of males. Values of antiGAD y antiTPO were higher in diabetic patients than families. No correlation between autoimmunity and glycemic control was detected.
authors.affiliation: Instituto de Endocrinología y Nutrición, Facultad de Medicina, Unidad de Apoyo a la Investigación, Hospital del Río Hortega, Universidad de Valladolid, Valladolid.
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: M
authors.initials: M
authors.lastname: Alonso Fernández
authors.forename: M
authors.initials: M
authors.lastname: González Sagrado
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.forename: J
authors.initials: J
authors.lastname: Martín Gil
authors.forename: M C
authors.initials: MC
authors.lastname: Terroba
authors.forename: L
authors.initials: L
authors.lastname: Cuéllar
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D005190:Family; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007223:Infant; D007328:Insulin / Q000276:immunology; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D007328:Insulin; D007453:Iodide Peroxidase; D005968:Glutamate Decarboxylase
vernacular_title: Estudio descriptivo del comienzo de la diabetes mellitus tipo 1 y sus familiares de primer grado.