Watching the DNA repair ensemble dance.
Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes, adaptor proteins, and chromatin constituents. In this issue of Cell, Lisby et al. (2004) provide a visual glimpse into how the diverse signaling and repair machines are organized in space and time around the deadliest genetic lesions--the DNA double-strand breaks.
Lukas
Jiri
J
Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK-2100, Copenhagen.
Bartek
Jiri
J
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010770:Phosphotransferases / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure
D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D004247:DNA; D010770:Phosphotransferases