Synthesis of novel 26-substituted milbemycin A4 derivatives and their acaricidal activities.
A series of novel 26-substituted milbemycin A4 derivatives was synthesized from 5-O-t-butyldimethylsilyl-26-hydroxymilbemycin A4 prepared by selenium dioxide oxidation of 5-O-t-butyldimethylsilyl-milbemycin A4. Their acaricidal activities were assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
Tsukiyama
Takahiro
T
Agroscience Research Laboratories, Sankyo Co., Ltd. 894, Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. tukiya@Sankyo-agro.co.jp
Kajino
Hisaki
H
Tsukamoto
Yoshihisa
Y
Nakagawa
Harumi
H
Yanai
Toshiaki
T
Sato
Kazuo
K
Yokoi
Shinji
S
Ichinose
Reiji
R
Tanaka
Keiji
K
D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology; D008925:Mites / Q000187:drug effects*; D013329:Structure-Activity Relationship
D018942:Macrolides; C027837:moxidectin