title: Recurrent acute pancreatitis after isoniazid.
abstract: Drug-induced acute pancreatitis should be in the differential diagnosis of acute abdomen occurring soon after initiation of tuberculosis treatment and chemoprophylaxis. Isoniazid-induced pancreatitis is potentially reversible; early recognition and drug withdrawal are warranted in the appropriate clinical setting. We present a case of reversible acute pancreatitis after isoniazid treatment of genitourinary tuberculosis, followed by recurrence of pancreatitis 12 years later when the patient received isoniazid again for pulmonary tuberculosis. Isoniazid-induced pancreatitis, if highly suspicious or confirmed with re-challenge test, mandates permanent avoidance of the drug.
authors.affiliation: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China. Chow_Kai_Ming@alumni.cuhk.net
authors.forename: K M
authors.initials: KM
authors.lastname: Chow
authors.forename: C C
authors.initials: CC
authors.lastname: Szeto
authors.forename: C B
authors.initials: CB
authors.lastname: Leung
authors.forename: P K T
authors.initials: PK
authors.lastname: Li
mesh_terms: D000208:Acute Disease; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D012008:Recurrence; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid