Depression and sex hormones in elderly women.
We aimed to study the relation between sex hormones and depression among elderly women. The study was carried out on 74 volunteered female subjects above 60 years of age. Each subject was asked to fulfill the geriatric depression scale (GDS) questionnaire and further evaluated for clinical depression by a psychiatrist using the DSM IV diagnostic criteria. For statistical analysis, subjects were later divided in two groups, according to the presence of clinical depression. Cognitive functions were assessed with the standardized mini mental test (SMMT). Disability in the activities of daily living was assessed with instrumental activities of daily living (IADL) scale. Plasma levels of estrogen, testosterone, progesterone, and dehydroepiandrosterone sulfate (DHEA-S) were measured with chemiluminescent methods, and plasma levels of androstenedione were measured with radioimmunoassay. Among 74 subjects, 34 (39%) had clinical depression. Age, number of years spent in education, SMMT scores, and IADL scores did not differ between the depressive and non-depressive groups. Plasma sex hormone levels were not found to be different between the two groups.
Erdinçler
Deniz
D
Geriatric Unit of the Internal Medicine Department, Cerrahpasa Medical School, Istanbul University, Turkey. pam@istanbul.edu.tr
Bugay
Gülcan
G
Ertan
Turan
T
Eker
Engin
E
D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000523:psychology; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology; D003687:Dehydroepiandrosterone / Q000097:blood; D003863:Depression / Q000097:blood*; D004967:Estrogens / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008163:Luminescent Measurements; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood
D004967:Estrogens; D012739:Gonadal Steroid Hormones; D013739:Testosterone; D003687:Dehydroepiandrosterone; D011374:Progesterone