title: PKC-interacting proteins: from function to pharmacology.
abstract: Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in regulating multiple cellular activities. The activity of this family is controlled tightly by several molecular mechanisms, including interaction with binding-partner proteins. These PKC-interacting proteins (C-KIPs) confer specificity for individual PKC isoforms by regulating the activity and cellular localization of PKC isoforms and, subsequently, the ability of these isoforms to specifically regulate cellular functional events. Although many C-KIPs have been identified by genome and proteome-mining approaches, it is important to address the specificity and function of the interactions in greater detail because they might form novel drug targets. In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development.
authors.affiliation: Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK. a.poole@bris.ac.uk
authors.forename: Alastair W
authors.initials: AW
authors.lastname: Poole
authors.forename: Giordano
authors.initials: G
authors.lastname: Pula
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Hers
authors.forename: David
authors.initials: D
authors.lastname: Crosby
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Jones
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D025941:Protein Interaction Mapping / Q000379:methods*; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D007527:Isoenzymes; D011493:Protein Kinase C