title: Can cumulative tobacco consumption, FTND score, and carbon monoxide concentration in expired air be predictors of chronic obstructive pulmonary disease?
abstract: Between 15% and 20% of smokers develop chronic obstructive pulmonary disease (COPD). The aim of the present study was to determine which characteristics of smoking, particularly the Fagerström Test for Nicotine Dependence (FTND) score, were associated with the risk of developing COPD. Data from the IBERPOC epidemiological study were analyzed. IBERPOC was a multicenter epidemiological study including 4035 individuals aged 40-69 years, 1023 (25%) of whom were active smokers. We analyzed the association between smoking characteristics--such as the cumulative consumption of tobacco, FTND score, and expired-air carbon monoxide levels--and the diagnosis of COPD. Among the smokers, 153 (15%) were diagnosed with COPD. A cumulative tobacco consumption of more than 30 pack-years (OR=4.24, 95% CI=2.83-6.36) and the FTND score (OR=1.11, 95% CI=1.02-1.21, for each point increase) were significantly associated with the diagnosis of COPD in the model obtained by logistic regression analysis with the full sample of smokers. Cumulative consumption of tobacco was associated with the diagnosis of COPD. For each point increase in the FTND score, the probability of a smoker developing COPD increased by 11%.
authors.affiliation: Unidad de Tabaquismo, Instituto de Salud Pública, Comunidad de Madrid, Spain. victorina@ctv.es
authors.forename: Carlos
authors.initials: C
authors.lastname: Jiménez-Ruiz
authors.forename: Marc
authors.initials: M
authors.lastname: Miravitlles
authors.forename: Víctor
authors.initials: V
authors.lastname: Sobradillo
authors.forename: Rafael
authors.initials: R
authors.lastname: Gabriel
authors.forename: José Luis
authors.initials: JL
authors.lastname: Viejo
authors.forename: Juan Fernando
authors.initials: JF
authors.lastname: Masa
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fernández-Fau
authors.forename: Carlos
authors.initials: C
authors.lastname: Villasante
mesh_terms: D000328:Adult; D001944:Breath Tests; D002248:Carbon Monoxide / Q000032:analysis*; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D014029:Tobacco Use Disorder / Q000150:complications*
chemical_list: D002248:Carbon Monoxide