Complete replacement of H2 by D2 via Pd/C-catalyzed H/D exchange reaction.
[reaction: see text] A general and in situ D2 gas generation method using 10% Pd/C-catalyzed H2-D2 exchange reaction in a H2-D2O system has been developed. H2 gas sealed in a reaction flask was efficiently converted into nearly pure D2 gas, which can be used for the reductive deuteration of substrates possessing reducible functionalities within the molecule.
Sajiki
Hironao
H
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. sajiki@gifu-pu.ac.jp
Kurita
Takanori
T
Esaki
Hiroyoshi
H
Aoki
Fumiyo
F
Maegawa
Tomohiro
T
Hirota
Kosaku
K