title: Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status.
abstract: Sex steroid hormones have multiple effects on lipid metabolism. We investigated the association between two common single nucleotide polymorphisms of the estrogen receptor 2 gene (ESR2), 1082G>A and 1730A>G, and PROGINS polymorphism of the progesterone receptor gene (PGR) with lipoprotein levels in a cross-sectional study with 472 women of European descent. The women were classified into three subgroups according to hormonal status, premenopausal women (n=187; mean age=34+/-9.7 years), postmenopausal women exposed to hormone replacement therapy (HRT) (n=118; 56+/-6.7 years) and postmenopausal women unexposed to HRT (n=167; 58+/-9.8 years). The premenopausal and postmenopausal women exposed to HRT, both carriers of G/A genotype, exhibited LDL-C (P=0.027 and 0.001, respectively) and T-chol levels (P=0.035 and 0.001, respectively) lower than carriers of G/G genotype. This association was not observed in postmenopausal women unexposed to HRT. These results suggest that ESR2 1082G>A genotype may influence LDL-C levels in women with abundant estrogen levels, due to either endogenous or exogenous sources.
authors.affiliation: Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Almeida
authors.forename: N
authors.initials: N
authors.lastname: Franken
authors.forename: M R
authors.initials: MR
authors.lastname: Zandoná
authors.forename: M C
authors.initials: MC
authors.lastname: Osório-Wender
authors.forename: M H
authors.initials: MH
authors.lastname: Hutz
mesh_terms: D000328:Adult; D000368:Aged; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000187:drug effects / Q000235:genetics*; D017698:Postmenopause / Q000097:blood / Q000187:drug effects / Q000235:genetics*; D017697:Premenopause / Q000097:blood / Q000187:drug effects / Q000235:genetics*; D011980:Receptors, Progesterone / Q000235:genetics*
chemical_list: D003278:Contraceptives, Oral, Hormonal; D047629:Estrogen Receptor beta; D008055:Lipids; D011980:Receptors, Progesterone