Persistence of Burkholderia multivorans within the pulmonary macrophage in the murine lung.
Differences in infection kinetics and host response between Burkholderia multivorans and Burkholderia cenocepacia were demonstrated in a pulmonary infection model in BALB/c mice. B. multivorans persisted in the lung, while B. cenocepacia was cleared. Indirect immunofluorescence and electron microscopy of B. multivorans-infected lungs localized bacteria to macrophages. Clearance of B. cenocepacia was associated with greater interleukin-1beta and neutrophil responses than the responses induced by B. multivorans.
Chu
Karen K
KK
Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada.
MacDonald
Kelly L
KL
Davidson
Donald J
DJ
Speert
David P
DP
D000818:Animals; D001835:Body Weight; D019117:Burkholderia / Q000145:classification* / Q000302:isolation & purification / Q000502:physiology*; D019121:Burkholderia Infections / Q000382:microbiology* / Q000473:pathology; D019084:Fluorescent Antibody Technique, Indirect; D008168:Lung / Q000166:cytology* / Q000382:microbiology*; D016676:Macrophages, Alveolar / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C