Second generation anti-cyclic citrullinated peptide (anti-CCP2) antibodies can replace other anti-filaggrin antibodies and improve rheumatoid arthritis diagnosis.
We compared the diagnostic performance of anti-cyclic citrullinated peptide antibodies detected with second-generation enzyme immunoassay (anti-CCP2) with that of IgM-rheumatoid factor (RF), anti-perinuclear factor (APF), and anti-keratin antibodies (AKA). The sensitivity of anti-CCP2 was better than that of APF and AKA: they were detected in 25% rheumatoid arthritis (RA) patients without detectable APF or AKA. Their specificity, evaluated in other inflammatory rheumatic disease, was similar to that of APF and AKA. Despite the lower specificity, IgM-RF in combination with anti-CCP2 is interesting, as they do not completely overlap. Anti-CCP2 antibody detection seems to be a good alternative to other anti-filaggrin antibodies in the diagnosis of RA.
Grootenboer-Mignot
S
S
Laboratory of Immunology, AP-HP Bichat-Cl, Bernard Hospital, 75877 Paris, France.
Nicaise-Roland
P
P
Delaunay
C
C
Meyer
O
O
Chollet-Martin
S
S
Labarre
C
C
D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D003937:Diagnosis, Differential; D000091344:Filaggrin Proteins; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000032:analysis; D007381:Intermediate Filament Proteins / Q000032:analysis / Q000276:immunology; D010456:Peptides, Cyclic / Q000276:immunology*; D012216:Rheumatic Diseases / Q000175:diagnosis; D012217:Rheumatoid Factor / Q000032:analysis / Q000276:immunology; D012680:Sensitivity and Specificity
D001323:Autoantibodies; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007075:Immunoglobulin M; D007381:Intermediate Filament Proteins; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor