title: [Case of NASH exacerbated after testectomy due to seminoma].
abstract: A 41-year-old Japanese male was admitted to our hospital because of the increased levels of serum AST, ALT, and gamma-GTP on December 18, 2002. He was diagnosed with right testis seminoma in 1994 and had received right high orchiectomy and radiation therapy. At that time, liver dysfunction was not pointed out. As weight was increased in 2001, liver dysfunction was pointed out. He was diagnosed as left testis seminoma in June, 2002, left high orchiectomy and chemotherapy was performed. Abdominal ultrasonography showed the moderate fatty liver, and hepatic histopathology revealed a typical and remarkable steatohepatitis with lymphocyte infiltration. He had no life history of alcohol-consumption, and he was diagnosed as non-alcoholic steatohepatitis (NASH). He was treated with a low-calorie diet, which showed favorable effects on his serum levels of AST, ALT, gamma-GTP, and LDH. This case suggests that the altered sex hormone balance might exacerbate NASH because liver dysfunction was particularly worsened after bilateral high orchiectomy.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Shusuke
authors.initials: S
authors.lastname: Morizono
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamuta
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohta
authors.forename: Marie
authors.initials: M
authors.lastname: Fukushima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kotoh
authors.forename: Munechika
authors.initials: M
authors.lastname: Enjoji
authors.forename: Hajime
authors.initials: H
authors.lastname: Nawata
mesh_terms: D000328:Adult; D004967:Estrogens / Q000172:deficiency; D005234:Fatty Liver / Q000209:etiology*; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000009:adverse effects*; D011183:Postoperative Complications; D018239:Seminoma / Q000601:surgery*; D013736:Testicular Neoplasms / Q000601:surgery*; D013739:Testosterone / Q000172:deficiency
chemical_list: D004967:Estrogens; D013739:Testosterone