title: Physicochemical, mechanical, and biological properties of bone cements prepared with functionalized methacrylates.
abstract: Bone cements prepared with methyl methacrylate (MMA) as a base monomer and either methacrylic acid (MAA) or diethyl amino ethyl methacrylate (DEAEMA) as comonomers were characterized in terms of curing behavior, mechanical properties, and their in vitro biocompatibility. The curing time and setting temperature were found to be composition dependent while the residual monomer was not greatly affected by the presence of either acidic or alkaline comonomers in the bone cements. For samples with MAA comonomer, a faster curing time and higher setting temperature were observed when compared to the cement with DEAEMA comonomer. In terms of mechanical properties, the highest compressive strength was exhibited by formulations containing MAA, while the highest impact strength was shown by the formulations prepared with DEAEMA. There were no differences observed between the two formulations for tensile, shear, and bending strength values. Similarly, fatigue crack propagation studies did not reveal differences with the addition of either DEAEMA or MAA.No differences were observed in the initial number of attached primary rat femur osteoblasts on the different bone cements and positive controls. However, after 48 h there was a reduced proliferation in the cells grown on bone cements containing MAA.
authors.affiliation: Grupo de Polímeros GPUSB, Dpto. Ciencia de los Materiales Laboratorio de Biotecnologíá, Dpto. de Biologíá Celular, Universidad Simon Bolivar, APTO 89000 Caracas 1080-A Venezuela.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Sabino
authors.forename: Diana
authors.initials: D
authors.lastname: Ajami
authors.forename: Vehid
authors.initials: V
authors.lastname: Salih
authors.forename: Showan N
authors.initials: SN
authors.lastname: Nazhat
authors.forename: Rossana
authors.initials: R
authors.lastname: Vargas-Coronado
authors.forename: Juan V
authors.initials: JV
authors.lastname: Cauich-Rodríguez
authors.forename: Ma Pau
authors.initials: MP
authors.lastname: Ginebra
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001843:Bone Cements / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation; D048429:Cell Size; D002478:Cells, Cultured; D019245:Compressive Strength; D004548:Elasticity; D006244:Hardness; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D051381:Rats; D033081:Shear Strength; D013696:Temperature; D013718:Tensile Strength; D044366:Transition Temperature
chemical_list: D001843:Bone Cements; D008689:Methacrylates