title: Opportunities for nanotechnology-based innovation in tissue proteomics.
abstract: Within this review we discuss two methodologies used in tissue proteomics, namely mass-spectrometry (MS)-based protein pattern diagnostics and protein microarrays. Further, we describe current goals within the field of tissue proteomics and suggest points of departure for designing nanotechnology-based tools that will enhance the role of molecularly based diagnostics and therapeutics development in clinical medicine.
authors.affiliation: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. gehod@mail.nih.gov
authors.forename: David H
authors.initials: DH
authors.lastname: Geho
authors.forename: Nicholas
authors.initials: N
authors.lastname: Lahar
authors.forename: Mauro
authors.initials: M
authors.lastname: Ferrari
authors.forename: Emanuel F
authors.initials: EF
authors.lastname: Petricoin
authors.forename: Lance A
authors.initials: LA
authors.lastname: Liotta
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D040901:Proteomics / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D013673:Technology Assessment, Biomedical
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins