title: Survival of in situ carcinoma of cervix uteri: a 50-year follow-up in Finland.
abstract: Preinvasive lesions of cervix uteri are regarded a curable disease despite some progression to invasive cancer. The ultimate outcome is not known. We estimated the 45-year survival of 12,655 patients with carcinoma in situ lesions diagnosed in 1953-2000 and reported to the Finnish Cancer Registry. Up to 30 years of follow-up there was about 1% decrease in cumulative relative survival per 5 years of follow-up. After that the excess mortality increased and the survival at 45 years was 84%. The 15-year survival was 100% in the patients under 30 at diagnosis and became the poorer the older the patient. Survival was 89% in the patients 60-74 at diagnosis. Women with carcinoma in situ are at substantial increased risk of death (>10%) only at high ages and independent of age at diagnosis.
authors.affiliation: Finnish Cancer Registry, Helsinki, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Hakama
authors.forename: Tapio
authors.initials: T
authors.lastname: Luostarinen
authors.forename: Timo
authors.initials: T
authors.lastname: Hakulinen
mesh_terms: D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012042:Registries; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000401:mortality*; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000401:mortality*