title: Efficacy of coronary angioplasty following conventional coronary thrombolysis in patients with acute myocardial infarction.
abstract: The efficacy of combined thrombolysis and angioplasty for the purpose of coronary reperfusion after acute myocardial infarction has been controversial. The present study was conducted, therefore, to evaluate the effects of angioplasty following administration of conventional thrombolytic agents on the long-term prognosis of acute myocardial infarction patients. A total of 409 patients admitted to the hospital within 12 hours of the onset of infarction between January 1990 and May 2001 were studied retrospectively. These included 151 patients treated with thrombolysis alone (group T), 73 patients treated with angioplasty alone (group A), and 35 patients treated with angioplasty after thrombolysis (group T&A). Group T&A had shorter intervals from onset to initial treatment than group A (3.0 hours vs 6.3 hours, p < 0.01), a higher reperfusion success rate than group T (91.4% vs 74.8%, p < 0.01), and more improved left ventricular wall motion than group A. One-year cardiac mortality rates tended to be higher in group T, which had a higher rate of unsuccessful reperfusion than groups T&A or A (8.1% vs 3.4% vs 3.5%). The frequencies of hemorrhagic complications were similar among the 3 groups. From these findings, we conclude that thrombolytic therapy with subsequent angioplasty is an effective strategy for achieving cardiac reperfusion following acute myocardial infarction.
authors.affiliation: Department of Cardiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan. hayashi@med.kindai.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hayashi
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Akio
authors.initials: A
authors.lastname: Kimura
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyataka
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Kurooka
authors.forename: Takaaki
authors.initials: T
authors.lastname: Taniwa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kiyoshima
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Matsuura
authors.forename: Norihiro
authors.initials: N
authors.lastname: Takeda
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
authors.forename: Ken
authors.initials: K
authors.lastname: Kanamasa
authors.forename: Kinji
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary; D001803:Blood Transfusion; D003627:Data Interpretation, Statistical; D048909:Diabetes Complications; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D015425:Myocardial Reperfusion; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D015607:Stents; D015912:Thrombolytic Therapy; D013997:Time Factors