Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province.
OBJECTIVE
To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection.


METHODS
One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP.


RESULTS
The frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects.


CONCLUSIONS
HLA-B*46 may be associated with its susceptibility to HIV-1 infections.
Xu
Ming-Yan
MY
National Centerfor STD/AIDS Control and Prevention, Beijing 100050, China.
Hong
Kun-Xue
KX
Deng
Xiao-Ling
XL
Li
Jun
J
Peng
Hong
H
Ruan
Yu-Hua
YH
Qin
Guan-Ming
GM
Xing
Hui
H
Xu
Xiao-Hu
XH
Shao
Yi-Ming
YM
D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D004247:DNA / Q000032:analysis; D005006:Ethnicity; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000235:genetics*; D006679:HIV Seropositivity / Q000097:blood; D015497:HIV-1 / Q000472:pathogenicity*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D011795:Surveys and Questionnaires
D015235:HLA-B Antigens; D004247:DNA