title: The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomy.
abstract: OBJECTIVE
  To compare the effects of remifentanil with alfentanil as a part of total intravenous anesthesia (TIVA) on plasma concentrations of cortisol, insulin, and glucose, and hemodynamic responses in patients undergoing abdominal hysterectomy.
  
  
  METHODS
  Randomized, double-blind study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  24 ASA physical status I female patients scheduled for abdominal hysterectomy.
  
  
  METHODS
  Premedicated patients were randomly allocated to receive either remifentanil-propofol (Group R) or alfentanil-propofol (Group A). The loading dose of the study drug was administered over 60 seconds (remifentanil l microg kg(-l) or alfentanil 10 microg kg(-l)) followed by a continuous infusion (remifentanil 0.2 microg kg(-l) min(-l) or alfentanil 0.5 microg kg(-l) min(-l)). In both groups, propofol was administered until loss of consciousness and maintained with a propofol infusion rate of 100 microg kg(-l) min(-l). After induction of anesthesia, all patients were manually ventilated by mask with O2-air mixture for 20 minutes. Then rocuronium 0.6 mg kg(-l) was given for tracheal intubation.
  
  
  METHODS
  Mean arterial pressure (MAP) and heart rate (HR) were recorded. Plasma concentrations of cortisol, insulin, and glucose were measured during anesthesia and in the recovery room.
  
  
  RESULTS
  In Group R, MAP and HR were lower after tracheal intubation and skin incision than in Group A (p < 0.05). Plasma cortisol concentrations decreased from baseline values at 20 minutes after induction, after tracheal intubation, and skin incision in Group R (p < 0.001). Plasma concentrations of cortisol and glucose increased from baseline values at 30 minutes after skin incision and continued to increase in both groups (p = 0.001). Plasma concentrations of cortisol, insulin, and glucose did not differ between groups at all sampling times.
  
  
  CONCLUSIONS
  Remifentanil provided better hemodynamic stability than alfentanil during anesthesia and surgery. However, both remifentanil and alfentanil had similar effects on the stress endocrine response to abdominal hysterectomy.
authors.affiliation: Department of Anesthesiology, Medical Faculty of Harran University, Sanliurfa, Turkey. sedemirbilek@inonu.edu.tr
authors.forename: Semra
authors.initials: S
authors.lastname: Demirbilek
authors.forename: Süleyman
authors.initials: S
authors.lastname: Ganidağli
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Cevdet
authors.initials: C
authors.lastname: Becerik
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Baysal
mesh_terms: D000328:Adult; D015760:Alfentanil / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007044:Hysterectomy; D007328:Insulin / Q000097:blood*; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology; D000077208:Remifentanil
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010880:Piperidines; D015760:Alfentanil; D000077208:Remifentanil; D006854:Hydrocortisone; D015742:Propofol