title: Comparison of 0.2% ropivacaine, 0.125% bupivacaine, and 0.25% bupivacaine for duration and magnitude of action in peripheral arterial blood flow induced by sympathetic block in dogs.
abstract: OBJECTIVE
  The aim of this study is to compare 0.2% ropivacaine with 0.125% bupivacaine or 0.25% bupivacaine for the duration and magnitude of the vasodilation effect induced by sympathetic block.
  
  
  METHODS
  We measured mean arterial pressure, heart rate, and right and left brachial artery blood flow (BABF) before and after cervicothoracic sympathetic block in 24 dogs. The experimental protocol was designed as follows: (1) left cervicothoracic sympathetic block with 1.0 mL 0.2% ropivacaine (n =8), (2) left cervicothoracic sympathetic block with 1.0 mL 0.125% bupivacaine (n=8), and (3) left cervicothoracic sympathetic block with 1.0 mL 0.25% bupivacaine (n=8).
  
  
  RESULTS
  Mean arterial pressure and heart rate did not change significantly throughout the study in either group. Left cervicothoracic sympathetic block with 0.2% ropivacaine increased left BABF significantly from 5 to 100 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 254 +/- 38%; P <.01). Left cervicothoracic sympathetic block with 0.125% bupivacaine increased left BABF significantly from 5 to 80 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 144 +/- 9%; P <.01). Left cervicothoracic sympathetic block with 0.25% bupivacaine increased left BABF significantly from 5 to 100 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 235 +/- 61%; P <.01).
  
  
  CONCLUSIONS
  Ropivacaine may be equally potent to bupivacaine at equal concentrations in sympathetic block in dogs.
authors.affiliation: Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Masatomo
authors.initials: M
authors.lastname: Tezuka
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kimura
authors.forename: Masaru
authors.initials: M
authors.lastname: Nagao
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hamaguchi
mesh_terms: D000577:Amides / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000627:therapeutic use*; D000818:Animals; D001340:Autonomic Nerve Block / Q000379:methods*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001916:Brachial Artery / Q000187:drug effects* / Q000502:physiology; D002045:Bupivacaine / Q000627:therapeutic use*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D000077212:Ropivacaine; D018709:Statistics, Nonparametric; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D002045:Bupivacaine