title: [Testosterone substitution in aging males. Which questions are answered?].
abstract: Testosterone effects different organs. Thus, a substitution of testosterone in the case of hormone deficiency seems plausible. By analysing 61 randomized studies, we demonstrated that in men older than 65 years there is an increase in bone mass (but not a decrease in fracture risk), an increase in lean body mass, and an increase in erythropoiesis. Changes in cardiovascular parameters, serum lipids, muscle mass, sexual functions, cognition and mood, however, are not clearly proven. The prostate is not negatively influenced. The lack of clear hazards from testosterone substitution in the aging male does not indicate unrestricted treatment safety. Until all doubts are cleared, each treatment should be carefully documented and monitored.
authors.affiliation: Klinik für Andrologie und Venerologie, Klinikum der Philipps-Universität Marburg. krause@mailer.uni-marburg.de
authors.forename: W
authors.initials: W
authors.lastname: Krause
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D015897:Comorbidity; D020249:Hormone Replacement Therapy / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013739:Testosterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000172:deficiency*
chemical_list: D013739:Testosterone; D017430:Prostate-Specific Antigen
vernacular_title: Testosteronsubstitution beim alternden Mann. Welche Fragen sind beantwortet?