Seropositivity for Helicobacter pylori antibodies is associated with lower occurrence of venous bypass graft occlusion.
Common chronic infections including those caused by cytomegalovirus (CMV), herpes simplex viruses (HSV), Helicobacter pylori and Chlamydia pneumoniae have previously been related to increased risk of coronary heart disease (CHD). We investigated the association between serology of these chronic infections and coronary bypass graft occlusions in 61 patients. As a result, IgG seropositivity rate against H. pylori was higher among patients without occlusion (82%) than in those with occlusion (45%) or apparently healthy controls (57%) (p = 0.004 and p = 0.008, respectively). In conclusion, H. pylori infection, as judged by IgG seropositivity, is associated with lower occurrence of venous bypass graft occlusion in patients with CHD and may thus be connected with better outcome and prognosis of CHD patients after bypass graft surgery.
Limnell
Vilho
V
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
Pasternack
Rafael
R
Karjalainen
Jussi
J
Virtanen
Vesa
V
Lehtimäki
Terho
T
Aittoniemi
Janne
J
D000328:Adult; D017677:Age Distribution; D000907:Antibodies, Bacterial / Q000032:analysis*; D000914:Antibodies, Viral / Q000032:analysis; D015331:Cohort Studies; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods; D003327:Coronary Disease / Q000175:diagnosis / Q000601:surgery; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D018139:Simplexvirus / Q000276:immunology / Q000302:isolation & purification
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral