title: Calculation of quality adjusted life years in the published literature: a review of methodology and transparency.
abstract: Economic evaluations alongside randomised controlled trials (RCTs) are increasingly being designed to prospectively collect patient-specific resource use and preference-based health status (utility) data. This paper examines the ways in which preference-based health status (utility) data are used to generate quality adjusted life years (QALYs). A literature review was carried out which identified 23 published cost utility analyses suitable for inclusion. The methodology employed to calculate QALYs was not always consistent, as well as being poorly reported. The use of different methodologies in the calculation of QALYs may influence the magnitude and direction of results of evaluations. Analysts need to be consistent and fully transparent in the methodology chosen to calculate QALYs.
authors.affiliation: Centre for Health Economics, University of York, Heslington, UK. gar2@york.ac.uk
authors.forename: Gerald
authors.initials: G
authors.lastname: Richardson
authors.forename: Andrea
authors.initials: A
authors.lastname: Manca
mesh_terms: D003362:Cost-Benefit Analysis; D003627:Data Interpretation, Statistical; D006305:Health Status Indicators; D006801:Humans; D017063:Outcome Assessment, Health Care / Q000379:methods* / Q000706:statistics & numerical data; D019057:Quality-Adjusted Life Years; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012107:Research Design