The Py235 proteins: glimpses into the versatility of a malaria multigene family.
Py235 rhoptry proteins, encoded by a multigene family of the rodent malaria parasite Plasmodium yoelii, combine a functional role in invasion with one of immune evasion, and have homologues in malaria parasites of humans. Investigations of Py235 are summarised and the perspectives for dissecting the molecular and biological mechanisms underlying these crucial phenomena are discussed.
Grüner
Anne Charlotte
AC
Département d'Immunologie, Institut Cochin, Inserm U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France.
Snounou
Georges
G
Fuller
Katy
K
Jarra
William
W
Rénia
Laurent
L
Preiser
Peter R
PR
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008288:Malaria / Q000469:parasitology; D005810:Multigene Family; D010967:Plasmodium yoelii / Q000472:pathogenicity*; D015800:Protozoan Proteins / Q000235:genetics*
D015800:Protozoan Proteins; C065352:rhoptry associated protein, Plasmodium