title: Evaluation of the GTI-ASP-1 platelet antigen genotyping kit for the determination of the HPA-1 genotype.
abstract: The human platelet antigen system HPA-1 is involved in most cases of neonatal alloimmune thrombocytopenia and posttransfusion purpura, and occasionally causes refractoriness to platelet transfusions. Complete concordance was obtained in genotyping for HPA-1 in all samples tested with the HPA-1 genotyping kit and a ligation-based typing method. However, the genotyping kit is less sensitive than ligation- based typing, which could be of importance when testing cells from amnionic fluid or from chorionic villi.
authors.affiliation: Department of Transfusion Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
authors.forename: T J
authors.initials: TJ
authors.lastname: Legler
authors.forename: C
authors.initials: C
authors.lastname: Hagner
authors.forename: M
authors.initials: M
authors.lastname: Köhler