[Fructosamine 3-kinase and protein repair].
It was thought until recently that fructosamines are not metabolized in mammalian cells. Quite to the contrary, a mammalian enzyme, fructosamine 3-kinase, has recently been identified, which phosphorylates fructosamines on their third carbon, making them unstable and leading to their shedding from proteins. Fructosamine 3-kinase is therefore responsible for protein deglycation, one of the few protein repair mechanisms that have been identified.
Van Schaftingen
E
E
D000818:Animals; D004260:DNA Repair / Q000502:physiology*; D004912:Erythrocytes / Q000378:metabolism*; D019270:Fructosamine / Q000378:metabolism*; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism; D010766:Phosphorylation; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000302:isolation & purification / Q000378:metabolism*
D019270:Fructosamine; D017853:Phosphotransferases (Alcohol Group Acceptor); C414347:fructosamine-3-kinase
Fructosamine 3-kinase et réparation des protéines.