title: Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.
authors.affiliation: Department of Chemistry, Boehringer Ingelheim, Canada, Ltd., Research and Development, 2100 Cunard St., Laval, Quebec, Canada, H7S2G5. slaplante@lav.boehringer-ingelheim.com
authors.forename: Steven R
authors.initials: SR
authors.lastname: LaPlante
authors.forename: Araz
authors.initials: A
authors.lastname: Jakalian
authors.forename: Norman
authors.initials: N
authors.lastname: Aubry
authors.forename: Yves
authors.initials: Y
authors.lastname: Bousquet
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Ferland
authors.forename: James
authors.initials: J
authors.lastname: Gillard
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lefebvre
authors.forename: Martin
authors.initials: M
authors.lastname: Poirier
authors.forename: Youla S
authors.initials: YS
authors.lastname: Tsantrizos
authors.forename: George
authors.initials: G
authors.lastname: Kukolj
authors.forename: Pierre L
authors.initials: PL
authors.lastname: Beaulieu
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry; D016174:Hepacivirus / Q000201:enzymology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011485:Protein Binding; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
chemical_list: D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D017361:Viral Nonstructural Proteins; C031000:benzimidazole; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase