The effect of age and gender on glucuronidation and sulphation in rat liver: a study using paracetamol as a model substrate.
The effect of age and sex on glucuronidation and sulphation was studied in vitro in rat liver fractions, using paracetamol (acetaminophen) as substrate. Glucuronidation was more rapid in females; sulphation in males. Age was not a determinant of either metabolic pathway in either sex.
Woodhouse
K
K
University of Wales College of Medicine, Cardiff Royal Infirmary (West Wing), Newport Road, Cardiff CF2 1SZ UK.
Herd
B
B