title: Long polar fimbriae contribute to colonization by Escherichia coli O157:H7 in vivo.
abstract: The contribution of long polar fimbriae to intestinal colonization by Escherichia coli O157:H7 was evaluated in sheep, conventional pigs, and gnotobiotic piglets. E. coli O157:H7 strains with lpfA1 and lpfA2 mutated were recovered in significantly lower numbers and caused fewer attachment and effacement lesions than the parent strain.
authors.affiliation: Department of Veterinary Pathology, Iowa State University, Ames, Iowa 50011, USA. dmjordan@iastate.edu
authors.forename: Dianna M
authors.initials: DM
authors.lastname: Jordan
authors.forename: Nancy
authors.initials: N
authors.lastname: Cornick
authors.forename: Alfredo G
authors.initials: AG
authors.lastname: Torres
authors.forename: Evelyn A
authors.initials: EA
authors.lastname: Dean-Nystrom
authors.forename: James B
authors.initials: JB
authors.lastname: Kaper
authors.forename: Harley W
authors.initials: HW
authors.lastname: Moon
mesh_terms: D000818:Animals; D004927:Escherichia coli Infections / Q000382:microbiology / Q000473:pathology; D019453:Escherichia coli O157 / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D010861:Fimbriae, Bacterial / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D005516:Food Microbiology; D007422:Intestines / Q000382:microbiology* / Q000473:pathology; D009154:Mutation / Q000235:genetics; D012756:Sheep / Q000382:microbiology*; D013552:Swine / Q000382:microbiology*
chemical_list: D029968:Escherichia coli Proteins