A genome scan of neuroticism in nicotine dependent smokers.
Neuroticism is a personality factor that has consistently been demonstrated to be associated with anxiety, depression, and other "internalizing" disorders. We analyzed a genome scan for neuroticism on a sample of 129 sib-pair families (113 with a single sibling pair, 18 with multiple sibling pairs) containing a total of 201 possible sibling pairs, ascertained for concordance on nicotine dependence. Using Merlin-Regress, we replicated peaks for neuroticism described by prior studies, on chromosomes 1 and 11 with LOD scores of 2.52 and 1.97 (P-value of 0.003 and 0.0108) respectively, and have some evidence for a novel finding on chromosome 12 with a LOD of 2.85 (P-value of 0.0014).
Neale
Benjamin M
BM
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Commonwealth University, Richmond, Virginia, USA. bneale@aroma.vipbg.vcu.edu
Sullivan
Patrick F
PF
Kendler
Kenneth S
KS
D000328:Adult; D002874:Chromosome Mapping; D005260:Female; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders / Q000150:complications / Q000235:genetics*; D010641:Phenotype; D012907:Smoking / Q000009:adverse effects*; D014029:Tobacco Use Disorder / Q000150:complications* / Q000209:etiology