title: Two new compounds from Ligularia dolichobotrys.
abstract: Two new compounds, a stigmasterol (1) and an eremophilenolide (2), were isolated from Ligularia dolichobotrys (Diels) together with ten known sesquiterpenoids, two known triterpenes and five known sterols. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2D NMR). In addition, bakkenolide A (3) exhibited effective antitumor activity to human leukemia cells (HL-60), human hepatoma cells (Bel-7402) and human ovarian neoplasm cells (HO-8910).
authors.affiliation: College of Chemistry and Chemical Engineering, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China.
authors.forename: Er-Wei
authors.initials: EW
authors.lastname: Li
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.forename: Zhong-Jian
authors.initials: ZJ
authors.lastname: Jia
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013265:Stigmasterol / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010840:Phytosterols; D012717:Sesquiterpenes; D013729:Terpenes; D014315:Triterpenes; C492472:eremophilenolide; D013265:Stigmasterol