title: Long-term idebenone treatment of vascular and degenerative brain disorders of the elderly.
abstract: A multicentre study with an open experimental design was carried out on 118 patients suffering from mild to moderate cognitive decline due to cerebrovascular and degenerative disorders (chronic cerebrovascular disorders, CCVD; multi-infarct dementia, MID; aging brain, AB; dementia of Alzheimer's type, DAT). All patients, after a wash-out period of 3 weeks, were treated with idebenone (45 mg twice daily by oral route) for a period of 6 months. Behavioral and cognitive measures (Sandoz Clinical Assessment of Geriatrics, SCAG; Serial Learning Test) were applied to evaluate the long term therapeutical aspects. The results, analyzed by multivariate analysis of variance and chi2 test, showed a significant improvement of the cognitive profile in all patients, more evident in CCVD and AB groups. No remarkable side-effects were found in all groups of patients, thus confirming good tolerability of idebenone.
authors.affiliation: Department of Neurology, C. Mondino Foundation, University of Pavia, Pavia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Nappi
authors.forename: G
authors.initials: G
authors.lastname: Bono
authors.forename: P
authors.initials: P
authors.lastname: Merlo
authors.forename: A
authors.initials: A
authors.lastname: Denaro
authors.forename: R
authors.initials: R
authors.lastname: Proietti
authors.forename: N
authors.initials: N
authors.lastname: Martucci
authors.forename: M
authors.initials: M
authors.lastname: Fioravanti