title: Bcl-2 and immunoglobulin gene rearrangements in patients with malaria related chronic splenomegaly.
abstract: Two cases of malaria related chronic splenomegaly, one with tropical splenic lymphoma with villous lymphocytes (TSLVL) and the other with hyperreactive malarial splenomegaly (HMS) were analyzed by cytology, histology, karyotyping, immunophenotyping, and polymerase chain reaction (PCR) for detection of bcl-2/JH and FR3/JH rearrangements on blood and bone marrow samples, at diagnosis and 12 months after malarial prophylaxis. The reported data suggest that the detection of FR3/JH rearrangement might contribute to the diagnosis of TSLVL in patients with malaria related chronic splenomegaly, for whom bcl-2/JH rearrangement may be a common molecular event.
authors.affiliation: Centre Hospitalier Universitaire Saint-Antoine, 184 rue du Faubourg St. Antoine, 75571 Paris cedex 12, France.
authors.forename: Cristina Mihaela
authors.initials: CM
authors.lastname: Dascalescu
authors.forename: Michelle
authors.initials: M
authors.lastname: Rosenzwajg
authors.forename: Hélène
authors.initials: H
authors.lastname: Bonte
authors.forename: Ilhem Agha
authors.initials: IA
authors.lastname: Mir
authors.forename: Malek
authors.initials: M
authors.lastname: Aoudjhane
authors.forename: Nicole Véronique
authors.initials: NV
authors.lastname: Smadja
authors.forename: François M
authors.initials: FM
authors.lastname: Lemoine
authors.forename: Albert
authors.initials: A
authors.lastname: Najman
mesh_terms: D000368:Aged; D001402:B-Lymphocytes; D002908:Chronic Disease; D005260:Female; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D008223:Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000469:parasitology; D008288:Malaria / Q000150:complications*; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000469:parasitology; D013163:Splenomegaly / Q000235:genetics* / Q000469:parasitology*
chemical_list: D007143:Immunoglobulin Heavy Chains; D019253:Proto-Oncogene Proteins c-bcl-2