title: Water uptake and release from iodine-containing bone cement.
abstract: Water uptake and release characteristics of PMMA cement containing the water-soluble contrast media iohexol or iodixanol have been investigated. The water uptake study revealed that iohexol had the highest uptake of water (3.7%) and that iodixanol had an uptake close to that of Palacos R (2.3% and 1.9%). The curves obtained showed the materials to follow classic diffusion theory, with an initial linearity with respect to t(1/2) making it possible to calculate the diffusion coefficients. This showed iohexol to have the lowest diffusion coefficient, Palacos R the highest, and iodixanol close to that of Palacos R. The release study showed that more iohexol than iodixanol was released from the bone cement; the long-term release was above 25 microg/mL for iohexol compared to slightly above 10 microg/mL for iodixanol. A microCT investigation showed that the risk of developing an observable radiolucent zone is negligible.
authors.affiliation: Department of Orthopaedics, Lund University Hospital, Lund, Sweden. fred.kjellson@ort.lu.se
authors.forename: F
authors.initials: F
authors.lastname: Kjellson
authors.forename: B
authors.initials: B
authors.lastname: Brudeli
authors.forename: I D
authors.initials: ID
authors.lastname: McCarthy
authors.forename: L
authors.initials: L
authors.lastname: Lidgren
mesh_terms: D000042:Absorption / Q000187:drug effects; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology; D007455:Iodine / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D001843:Bone Cements; D014867:Water; D007455:Iodine