title: Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines.
abstract: Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described.
authors.affiliation: Instituto de Quimica, Unicamp, CP 6154, 13084-971, Campinas, São Paulo, Brazil.
authors.forename: Angelo
authors.initials: A
authors.lastname: de Fatima
authors.forename: Luciana Konecny
authors.initials: LK
authors.lastname: Kohn
authors.forename: Márcia Aparecida
authors.initials: MA
authors.lastname: Antônio
authors.forename: João Ernesto
authors.initials: JE
authors.lastname: de Carvalho
authors.forename: Ronaldo Aloise
authors.initials: RA
authors.lastname: Pilli
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones; C108954:argentilactone