title: Serum leptin concentrations in patients with severe ovarian hyperstimulation syndrome during in vitro fertilization-embryo transfer treatment.
abstract: OBJECTIVE
  To investigate the changes in serum leptin concentration in the conception cycle of severe ovarian hyperstimulation syndrome (OHSS).
  
  
  METHODS
  Prospective longitudinal study of 66 IVF-ET cycles between May 2000 and June 2002.
  
  
  METHODS
  Infertility outpatient clinic at a Japanese medical school.
  
  
  METHODS
  Infertile patients undergoing IVF-ET cycles at the infertility outpatient clinic were divided into three groups consisting of group 1 (conception-cycle patients with severe OHSS, n = 9), and group 2 (conception cycle, non-OHSS, n = 28), and group 3 (nonconception cycle, non-OHSS, n = 29).
  
  
  METHODS
  Blood samples were collected at five different periods. Period I, on the first day of ovarian stimulation with FSH; period II, at hCG administration before oocyte retrieval; period III, 7 days after oocyte retrieval; period IV, 14 days after oocyte retrieval; and period V, 21 days after oocyte retrieval.
  
  
  METHODS
  Serum leptin concentration.
  
  
  RESULTS
  The serum leptin concentration was low in the OHSS group compared with that of the non-OHSS groups in all serum samples, with significant levels at periods III (vs. groups 2 and 3; P<.05) and IV (vs. group 3; P<.01). A twofold increase of leptin concentration from period I to period II (P<.05) was observed in all groups.
  
  
  CONCLUSIONS
  The change pattern in serum leptin concentration might provide a great contribution to the pathophysiology development of OHSS patients during assisted reproductive treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi 329-0498, Japan.
authors.lastname: Ayustawati
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shibahara
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirano
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Satoru
authors.initials: S
authors.lastname: Takamizawa
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D020738:Leptin / Q000097:blood*; D008137:Longitudinal Studies; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood* / Q000503:physiopathology
chemical_list: D020738:Leptin