Ischemic stroke: "acidotoxicity" is a perpetrator.
Ischemic stroke is a devastating neurological disease. The responsible mechanisms are not completely understood. In this issue of Cell, Xiong et al. (2004) elucidate a molecular mechanism by which acidosis damages the brain during ischemia.
Huang
Yangzhong
Y
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
McNamara
James O
JO
D000138:Acidosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D018698:Glutamic Acid / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D009410:Nerve Degeneration / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D017470:Receptors, Glutamate / Q000187:drug effects / Q000378:metabolism; D020521:Stroke / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*
D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D017470:Receptors, Glutamate; D018698:Glutamic Acid