Effect of Polygala tenuifolia root on behavioral disorders by lesioning nucleus basalis magnocellularis in rat.
We investigated whether an aqueous extract of Polygala tenuifolia Willd (PTW) could improve the rats' memory and behavioral disorders produced by lesioning nucleus basalis magnocellularis (NBM) in rats. The animals were divided into four groups for surgery, and following that they were orally administered PTW extract for 7 and 21 days. Each group consisted of eight male Sprague-Dawley rats and were treated as follows:


METHODS
no surgery (n = 8), PBS: 1M (mol/L) phosphate buffered saline (n = 8), IBO: 0.12 M (n = 8), QUIS: 0.12 M (n = 8). Two 0.5 microL injections were made in the vicinity of the bilateral side of the nucleus basalis magnocellularis (NBM). All rats were tested in the neurological tests and the step-through passive avoidance memory test during pre-surgery, surgery and post-surgery drug treatment. The results suggest that PTW extract has some repairing effects on the memory and behavioral disorders produced by lesioning of the NBM in rats.
Chen
Yung-Li
YL
Graduate Institute of Chinese Medical Science, China Medical University, 91 HSue-Hsi Rd., Taichung City, Taiwan.
Hsieh
Ching-Liang
CL
Wu
Ping-Hsien Benson
PH
Lin
Jaung-Geng
JG
D000818:Animals; D020532:Basal Nucleus of Meynert / Q000187:drug effects* / Q000502:physiology; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000523:psychology; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification; D018517:Plant Roots; D031801:Polygala; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts