title: Ca2+ regulation and gene expression in normal brain aging.
abstract: Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca(2+) regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.
authors.affiliation: Department of Physiology, Division of Medical Sciences, The University of Birmingham, Edgbaston B15 2TT, UK. e.c.toescu@bham.ac.uk <e.c.toescu@bham.ac.uk>
authors.forename: Emil C
authors.initials: EC
authors.lastname: Toescu
authors.forename: Alexei
authors.initials: A
authors.lastname: Verkhratsky
authors.forename: Philip W
authors.initials: PW
authors.lastname: Landfield
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D009474:Neurons / Q000502:physiology*
chemical_list: D002118:Calcium