Correlation between in vitro susceptibility of Scedosporium apiospermum to voriconazole and in vivo outcome of scedosporiosis in guinea pigs.
We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Scedosporium apiospermum in immunodepressed guinea pigs. Animals were infected with two strains; one required a VRC MIC of 0.5 to 1 microg/ml, common for this fungus, and the other required a high MIC (8 microg/ml), unusual in this species. VRC prolonged survival and reduced fungal load in kidney and brain tissues of the animals infected with the first strain but was unable to prolong survival or to reduce fungal load in brain tissue for the latter strain.
Capilla
Javier
J
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain.
Guarro
Josep
J
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology; D015169:Colony Count, Microbial; D003470:Culture Media; D006168:Guinea Pigs; D007668:Kidney / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000188:drug therapy* / Q000382:microbiology; D009924:Organ Culture Techniques; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use*; D021681:Scedosporium / Q000187:drug effects*; D016019:Survival Analysis; D016896:Treatment Outcome; D014230:Triazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D003470:Culture Media; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole