title: Fulminant intravascular lymphoma presenting as fever of unknown origin.
abstract: Intravascular large cell lymphoma (IVLL) is a rare neoplasm characterized by the proliferation of malignant lymphoid cells within the lumens of small to medium-sized blood vessels. The central nervous system, skin, and endocrine systems are most commonly involved. IVLL may disseminate to the heart, pancreas, liver, spleen, kidneys, and adrenal glands. We report a 52-year-old patient who was admitted for fever of unknown origin for 3 weeks, jaundice and abnormal liver function tests. Fever, high levels of bilirubin, severe anemia, thrombocytopenia, and a very fulminant course characterized the clinical picture. Although bone marrow involvement is quite rare, the diagnosis of IVLL in this patient was done by bone marrow biopsy. The patient was treated with CHOP protocol and received the first course but the aggressive disease led to the patient's death.
authors.affiliation: Department of Internal Medicine B, Rabin Medical Center, Petah Tikva, Sackler School of Medicine, Tel-Aviv University, Israel. alizaz@clalit.org.il
authors.forename: Aliza
authors.initials: A
authors.lastname: Zeidman
authors.forename: Alon
authors.initials: A
authors.lastname: Horowitz
authors.forename: Zinaida
authors.initials: Z
authors.lastname: Fradin
authors.forename: Amos
authors.initials: A
authors.lastname: Cohen
authors.forename: Lea
authors.initials: L
authors.lastname: Wolfson
authors.forename: Okon
authors.initials: O
authors.lastname: Elimelech
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001663:Bilirubin / Q000378:metabolism; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005335:Fever of Unknown Origin / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008111:Liver Function Tests; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000188:drug therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009383:Neoplasms, Vascular Tissue / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D001663:Bilirubin; D011241:Prednisone