title: Development of the mouse retina: emerging morphological diversity of the ganglion cells.
abstract: The time course and regulatory mechanisms of dendritic development are subjects of intense interest. We approached these problems by investigating dendritic morphology of retinal ganglion cells (RGCs) at four early postnatal stages. The RGCs develop from a diffusely stratified and poorly differentiated group at birth (P0), to 16 distinct, morphologically well-defined subtypes before eye opening (P13). Even before bipolar cells make synaptic contacts with the RGCs (P8), most adultlike RGC subtypes are already present. Similar to previous studies in other mammalian species, our results indicate that the initiation of the RGC morphological maturation is independent of light stimulation and of formation of glutamatergic synapses. This study narrowed down the window of RGCs morphological maturation and highlighted a few early postnatal events as potential factors controlling the developmental process. Because mouse is the most popular mammalian model for genetic manipulation, this study provided a foundation for further exploring regulatory mechanisms of RGC dendritic development.
authors.affiliation: Institute of Neuroscience and Shanghai Research Center for Life Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Diao
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Sun
authors.forename: Qiudong
authors.initials: Q
authors.lastname: Deng
authors.forename: Shigang
authors.initials: S
authors.lastname: He
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D048429:Cell Size; D051379:Mice; D008810:Mice, Inbred C57BL; D012160:Retina / Q000166:cytology / Q000254:growth & development; D012165:Retinal Ganglion Cells / Q000166:cytology* / Q000502:physiology*