Opportunities for nanotechnology-based innovation in tissue proteomics.
Within this review we discuss two methodologies used in tissue proteomics, namely mass-spectrometry (MS)-based protein pattern diagnostics and protein microarrays. Further, we describe current goals within the field of tissue proteomics and suggest points of departure for designing nanotechnology-based tools that will enhance the role of molecularly based diagnostics and therapeutics development in clinical medicine.
Geho
David H
DH
FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. gehod@mail.nih.gov
Lahar
Nicholas
N
Ferrari
Mauro
M
Petricoin
Emanuel F
EF
Liotta
Lance A
LA
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D040901:Proteomics / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D013673:Technology Assessment, Biomedical
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins