C825T polymorphism of the G-protein beta3 subunit gene and atrial fibrillation: association of the TT genotype with a reduced risk for atrial fibrillation.
BACKGROUND
A polymorphism consisting of a C825T substitution in the G-protein beta(3) subunit gene (GNB3) has been associated with enhanced human atrial inward rectifier potassium currents regarding the TT genotype. Therefore, we investigated a possible impact of the GNB3 C825T polymorphism on atrial fibrillation in an association study.


METHODS
Two hundred ninety-one consecutive patients admitted to our center with atrial fibrillation (age, 58 +/- 10 years) and 292 consecutive control patients without atrial tachyarrhythmias (59 +/- 11 years) were genotyped for the C825T polymorphism. Patients with coronary heart disease, valvular heart disease, or cardiomyopathy were excluded from the study. Both patient groups had a similar incidence of cardiovascular risk factors (hypertension, hypercholesterolemia, body mass index).


RESULTS
The prevalence of the GNB3 TT genotype was significantly lower in patients with atrial fibrillation (5.8%) than in the control group (12.0%); however, no significant differences in the frequencies of the CT and CC genotypes were found. The TT genotype was associated with a 54% decrease in the adjusted risk (OR from a multivariant model, 0.46; 95% CI, 0.24 to 0.87; P =.02) for the occurrence of atrial fibrillation.


CONCLUSIONS
The current study suggests an association between the GNB3 TT genotype and a reduced risk for the occurrence of atrial fibrillation.
Schreieck
Juergen
J
Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. Schreieck@dhm.mhn.de
Dostal
Stefan
S
von Beckerath
Nicolas
N
Wacker
Annette
A
Flory
Michelle
M
Weyerbrock
Sonja
S
Koch
Werner
W
Schömig
Albert
A
Schmitt
Claus
C
D001281:Atrial Fibrillation / Q000235:genetics*; D005260:Female; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk
C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins