Effect of artificial liver support system on patients with severe viral hepatitis: a study of four hundred cases.
OBJECTIVE
To assess the effect of artificial liver support system (ALSS) on patients with severe viral hepatitis, who were divided into treatment group and control group.


METHODS
Four hundred in-hospital patients enrolled during 1995-2003 who received ALSS therapy were studied as the treatment group. Four hundred in-hospital patients enrolled during 1986-1994 who received other medical therapies served as the control group. The methods of ALSS used included plasma exchange, hemoperfusion, hemofiltration, continuous hemodiafiltration (CHDF). The effect of ALSS treatment was studied in patients at different stages of the disease.


RESULTS
The cure rate of acute and subacute severe hepatitis in the treatment group was 78.9% (30/38), and was 11.9% (5/42) in the control group. The improved rate of chronic severe hepatitis in the treatment group was 43.4% (157/362), and was 15.4% (55/358) in the control group. We found that patients treated with ALSS in the early or middle stage of the disease had much higher survival rates than patients in the end stage of the disease.


CONCLUSIONS
ALSS is an effective and safe therapy for severe viral hepatitis.
Li
Lan-Juan
LJ
Department of Infectious Disease, First Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China. ljli@zjwst.gov.cn
Yang
Qian
Q
Huang
Jian-Rong
JR
Xu
Xiao-Wei
XW
Chen
Yue-Mei
YM
Fu
Su-Zhen
SZ
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood; D002908:Chronic Disease; D004867:Equipment Design; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000401:mortality; D006801:Humans; D017093:Liver Failure / Q000209:etiology / Q000628:therapy*; D008111:Liver Function Tests; D019164:Liver, Artificial; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000596:Amino Acids