The link between IFN-gamma and allograft arteriopathy: is the answer NO?
Vascularized organ transplants often fail because of smooth muscle cell migration and proliferation in the intima of graft arteries, leading to progressive lumenal narrowing and resultant ischemic damage. Graft arterial disease is caused by IFN-gamma secreted by alloreactive T cells. New evidence indicates that IFN-gamma dysregulates expression of the enzymes eNOS and iNOS in graft-infiltrating leukocytes. Dysregulated NO synthase expression occurs prior to and is causally linked to intimal smooth muscle cell accumulation.
Mitchell
Richard N
RN
Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Lichtman
Andrew H
AH
D001158:Arteries / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000201:enzymology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000276:immunology; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D014184:Transplantation, Homologous / Q000276:immunology* / Q000473:pathology*
D009569:Nitric Oxide; D007371:Interferon-gamma; C496319:NOS2 protein, human; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III