title: Vascular wall damage in rats induced by methidathion and ameliorating effect of vitamins E and C.
abstract: We examined the effect of subacute methidathion (MD) administration on vascular wall damage and evaluated the ameliorating effects of combination of vitamins E and C against MD toxicity. The experimental groups were: rats treated with corn oil (control group), rats treated with 5 mg/kg MD (MD), and rats treated with 5 mg/kg body weight MD plus vitamin E and vitamin C (MD+Vit). The groups were given MD by gavage on 5 days a week for 4 weeks at a daily dose 5 mg/kg (MD and MD+Vit) using corn oil as the vehicle. Vitamins E and C were injected at doses of 50 mg/kg intramuscularly and 20 mg/kg intraperitoneally, respectively, after the treatment with MD in the MD+Vit group. The levels of malondialdehyde (MDA) were determined in the aortic tissue. Histopathological examination was examined in the thoracic aortic tissue. MDA levels were higher in the MD group than the control group and lower in the MD+Vit group than MD group. MD administration led to irregulation, prominent breaks, and fragmentation of the elastic fibers but decrease in the irregulation and fragmantation of the elastic fibers with the combination of vitamins E and C in MD-treated rats. In conclusion, it is likely that subacute MD administration caused vascular wall damage, and that treatment with a combination of vitamins E and C after the administration of MD can reduce vascular wall damage caused by MD.
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, University of Süleyman Demirel, Isparta, Turkey. turhan.kvc@doctor.com
authors.forename: Turhan
authors.initials: T
authors.lastname: Yavuz
authors.forename: Namik
authors.initials: N
authors.lastname: Delibas
authors.forename: Bekir
authors.initials: B
authors.lastname: Yildirim
authors.forename: Irfan
authors.initials: I
authors.lastname: Altuntas
authors.forename: Ozden
authors.initials: O
authors.lastname: Candir
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cora
authors.forename: Nermin
authors.initials: N
authors.lastname: Karaman
authors.forename: Erdogan
authors.initials: E
authors.lastname: Ibrisim
authors.forename: Ali
authors.initials: A
authors.lastname: Kutsal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001205:Ascorbic Acid / Q000494:pharmacology*; D007273:Injections, Intramuscular; D007306:Insecticides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D007306:Insecticides; D009946:Organothiophosphorus Compounds; D014810:Vitamin E; D008315:Malondialdehyde; D001205:Ascorbic Acid; C005828:methidathion