Exercise plus n-3 fatty acids: additive effect on postprandial lipemia.
The purpose of this study was to examine changes in postprandial lipemia (PPL) in recreationally active males following aerobic exercise, omega-3 fatty acids (n-3FA) supplementation, and the combination of the two. PPL following a high-fat meal was measured in 10 recreationally active males (25 +/-1.5 years) under each of the following conditions: no exercise and no n-3 FA supplementation (control); exercise and no n-3FA supplementation (exercise); n-3FA supplementation and no exercise (n-3FA); and exercise and n-3 FA supplementation (combined). Blood was collected before the high-fat meal and at 2, 4, 6, and 8 hours after the meal to assess the PPL response. Supplementation consisted of 4.0 g of n-3FA per day for 5 weeks. Triglyceride (TG) peak response, the total area under the TG curve (TG-AUCT), and the incremental area under the TG curve (TG-AUCI) were used to define the PPL response. TG peak response was significantly reduced 38% by n-3FA supplementation and 50% by the combination of exercise and n-3FA supplementation. N-3FAs significantly reduced the TG-AUCT by 27% and by 42% when combined with exercise. When compared with the exercise trial, the TG-AUCT during the combined trial was significantly lower. Exercise, n-3FAs, and the combination significantly reduced the TG-AUCI by 40%, 42%, and 58%, respectively. These results suggest that the combination of exercise and n-3FA supplementation reduce PPL to a greater degree in recreationally active males when compared with the individual treatments.
Smith
Bryan K
BK
Center for Physical Activity and Weight Management, Schiefelbusch Life Span Institute, University of Kansas, Lawrence, USA.
Sun
Grace Y
GY
Donahue
Owen M
OM
Thomas
Tom R
TR
D000328:Adult; D019540:Area Under Curve; D001823:Body Composition / Q000502:physiology; D018592:Cross-Over Studies; D019587:Dietary Supplements; D002149:Energy Intake; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005227:Fatty Acids / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D008055:Lipids; D014280:Triglycerides; D008071:Lipoprotein Lipase