CuBr-catalyzed efficient alkynylation of sp3 C-H bonds adjacent to a nitrogen atom.
A simple and effective catalytic method to construct propargylamine was developed by using copper bromide and tert-BuOOH via a combination of sp3 C-H bond and sp C-H bond activations followed by C-C bond formation.
Li
Zhiping
Z
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
Li
Chao-Jun
CJ