Familial hypercholesterolemia: genetic predisposition to atherosclerosis.
Familial hypercholesterolemia is one of the most frequent genetic disorders. The increased cholesterol levels in the plasma low-density lipoprotein fraction due to the diminished number or absence of LDL receptors predispose affected individuals to premature atherosclerosis and cardiovascular disease.
Engler
Mary B
MB
Department of Physiological Nursing, School of Nursing, University of California, San Francisco, CA, USA.
D001161:Arteriosclerosis / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis