title: Lipoxygenase inhibitory constituents from Periploca aphylla.
abstract: Bisflavan-3-ols 1 and 2 and norterpenoid 3 have been isolated from the methanolic extract of the whole plant of Periploca aphylla. Their structures have been assigned on the basis of spectroscopic analysis including 1D and 2D NMR techniques. In addition, o-phthalic acid bis(2-ethylnonyl) ester (4), 1,3,6-trihydroxy-2,5-dimethoxyxanthone (5), and (+)-lyoniresinol (6) have been reported for the first time from this species. Compounds 1-3 displayed evident inhibitory potential against the enzyme lipoxygenase in a concentration-dependent fashion with IC(50) values 19.7, 13.5, and 150.1 microM, respectively.
authors.affiliation: International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Aziz-Ur-Rehman
authors.initials: AU
authors.lastname: Aziz-Ur-Rehman
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.forename: Hafiz Rub
authors.initials: HR
authors.lastname: Nawaz
authors.forename: Habib
authors.initials: H
authors.lastname: Ahmad
authors.forename: Sarfraz Ahmad
authors.initials: SA
authors.lastname: Nawaz
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D003510:Cyclohexanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D031109:Periploca / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C493043:2alpha,6alpha-dihydroxy-5-((E)-3'-hydroxy-3'-methyl-1'-butenyl)-6-methyl-4-cyclohexen-3-one; D003510:Cyclohexanes; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; D013729:Terpenes; C493045:catechin-(3'-O-3''')-afzelechin; C493046:epicatechin-(3'-O-7'')-epiafzelechin