Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis.
BACKGROUND
Prognostic factors and outcome are incompletely known in childhood mesangiocapillary glomerulonephritis (MCGN). This study aimed to correlate renal outcome with clinical and histopathological variables.


METHODS
We conducted a two-centre retrospective analysis of children with MCGN.


RESULTS
Fifty-three children presented at a mean age of 8.8 years (range: 13 months-15 years). They were followed for a median of 3.5 years (range: 0-17 years). Histological classification identified 31 type 1, 14 type 2, two type 3 and six undetermined type. Mean renal survival [time to end-stage renal failure (ESRF)] was projected to be 12.2 years [confidence interval (CI): 9.7-14.6 years]. Five and 10 year renal survival was 92% (CI: 88-100%) and 83% (CI: 74-92%), respectively. Those with nephrotic syndrome at presentation had mean renal survival of 8.9 years (CI: 7.1-10.7 years) vs 13.6 years for those without (CI: 10.8-16.5 years) (P = 0.047). The mean estimated glomerular filtration rate (eGFR) at 1 year in those who progressed to ESRF was 52 vs 98 ml/min/1.73 m2 in those who did not (P < 0.001). Chronic damage scored on the first biopsy in 31 children (one centre) was positively associated with adverse renal outcome at 5 years: <20% was associated with 100% and > or =20% with 71% 5-year renal survival (P = 0.006). In 29 children treated with steroid there was a higher proportion (76%) with reduced eGFR at presentation and a significantly higher incidence of nephrotic syndrome (P = 0.002) and hypertension (P = 0.037). There were no significant differences in outcome eGFR, hypertension or proteinuria.


CONCLUSIONS
Nephrotic syndrome at presentation and subnormal eGFR at 1 year were adverse features. The finding that structural disease at onset predicted poor renal outcome at 5 years has implications for the design of therapeutic trials. Treatment of MCGN was variable and not evidence-based.
Cansick
Janette C
JC
Department of Paediatric Nephrology, Birmingham Children's Hospital, Birmingham, UK. jcansick@doctors.org.uk
Lennon
Rachel
R
Cummins
Carole L
CL
Howie
Alexander J
AJ
McGraw
Mary E
ME
Saleem
Moin A
MA
Tizard
E Jane
EJ
Hulton
Sally-Anne
SA
Milford
David V
DV
Taylor
C Mark
CM
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005919:Glomerular Filtration Rate; D015432:Glomerulonephritis, Membranoproliferative / Q000401:mortality* / Q000473:pathology; D006801:Humans; D007223:Infant; D007678:Kidney Glomerulus / Q000473:pathology; D011379:Prognosis; D011507:Proteinuria / Q000401:mortality; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome