title: Atopic dermatitis -- a total genome-scan for susceptibility genes.
abstract: Atopic dermatitis is one of the most common chronic diseases of childhood and closely related to other clinical manifestations of allergy. The incidence is high and still increasing. The genetic contribution to disease development is substantial and complex. Only recently genetic research has begun to focus on this phenotype, and specific susceptibility genes remain to be found. To identify candidate regions holding genes for atopic dermatitis we performed a genome-scan in Danish affected sib-pair families containing sib-pairs matching a phenotype definition of both clinical atopic dermatitis and confirmed specific allergy. The scan was undertaken using 446 microsatellite markers and non-parametric linkage results were obtained from the MAPMAKER/SIBS computer program. We found evidence of linkage to three candidate regions in chromosomes 3p (MLS=2.14), 4p (MLS=2.00) and 18q (MLS=2.25), one of which has not been reported previously. Eight additional regions showed weaker but positive results.
authors.affiliation: Institute of Human Genetics, University of Aarhus, Denmark. ah@humgen.au.dk
authors.forename: Annette
authors.initials: A
authors.lastname: Haagerup
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Bjerke
authors.forename: Peter Oluf
authors.initials: PO
authors.lastname: Schiøtz
authors.forename: Ronald
authors.initials: R
authors.lastname: Dahl
authors.forename: Helle Glud
authors.initials: HG
authors.lastname: Binderup
authors.forename: Qihua
authors.initials: Q
authors.lastname: Tan
authors.forename: Torben Arvid
authors.initials: TA
authors.lastname: Kruse
mesh_terms: D000328:Adult; D002648:Child; D002875:Chromosomes; D003718:Denmark; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D016678:Genome; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010641:Phenotype; D035781:Siblings