Acylated flavonoids and phenol glycosides from Veronica thymoides subsp. pseudocinerea.
A new acylated flavone glucoside, 3'-hydroxyscutellarein 7-O-(6''-O-protocatechuoyl)-beta-glucopyranoside (1), and a new phenol glucoside, 3,5-dihydroxyphenethyl alcohol 3-O-beta-glucopyranoside (6) were isolated from Veronica thymoides subsp. pseudocinerea together with seven known flavone, phenol and lignan glycosides; 3'-hydroxyscutellarein 7-O-(6''-O-trans-feruloyl)-beta-glucopyranoside (2), 3'-hydroxy, 6-O-methylscutellarein 7-O-beta-glucopyranoside (3), luteolin 7-O-beta-glucopyranoside (4), isoscutellarein 7-O-(6'''-O-acetyl)-beta-allopyranosyl (1''' --> 2'')-beta-glucopyranoside (5), 3,4-dihydroxyphenethyl alcohol 8-O-beta-glucopyranoside (7), benzyl alcohol 7-O-beta-xylopyranosyl (1" --> 2')-beta-glucopyranoside (8), and (+)-syringaresinol 4'-O-beta-glucopyranoside (9). Compounds 2, 3 and 7-9 were reported for the first time in the genus Veronica. The structures of the isolates were determined by means of spectroscopic (UV, IR, 1D and 2D NMR, HR ESI-MS) methods. Isolated compounds (1-7) exhibited potent radical scavenging activity against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.
Saracoglu
Iclal
I
Faculty of Pharmacy, Department of Pharmacognosy, Hacettepe University, 06100 Ankara, Turkey. isaracog@hacettepe.edu.tr
Varel
Mehtap
M
Harput
U Sebnem
US
Nagatsu
Akito
A
D000107:Acetylation; D001713:Biphenyl Compounds; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008860:Microscopy, Ultraviolet; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D010851:Picrates / Q000302:isolation & purification; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D032264:Veronica / Q000737:chemistry*
D001713:Biphenyl Compounds; D005419:Flavonoids; D006027:Glycosides; D010636:Phenols; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl