The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice.
The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances. Now, in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 microg, intraperitoneally or intragastrically) (i) strongly opposed acute alcohol (4 g/kg intraperitoneally) intoxication (i.e., quickly produced and sustained anesthesia, hypothermia, increased ethanol blood values, 25% fatality, 90-min assessment period) given before or after ethanol, and (ii) when given after abrupt cessation of ethanol (at 0 or 3 or 7 h withdrawal time), attenuated withdrawal (assessed through 24 hours) after 20%-alcohol drinking (7.6 g/kg) through 13 days, with provocation on the 14th day.
Blagaic
Alenka Boban
AB
Department of Pharmacology Medical Faculty University of Zagreb, Salata 11, P.O. Box 916, 10000 Zagreb, Croatia.
Blagaic
Vladimir
V
Romic
Zeljko
Z
Sikiric
Predrag
P
D020270:Alcohol Withdrawal Seizures / Q000139:chemically induced / Q000517:prevention & control; D000437:Alcoholism / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011506:Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors
D000897:Anti-Ulcer Agents; D010446:Peptide Fragments; D011506:Proteins; D000431:Ethanol; C083833:BPC 157