GABAergic neuron death in the striatum following kainate-induced damage of hippocampal neurons: evidence for the role of NO in locomotion.
The authors examined the role of nitric oxide (NO) in the relationship between kainate-induced neuronal death and locomotion changes. Locomotion was significantly increased 1 h after kainate injection, suggesting that kainate induced NO and dopamine release. Cell death occurred in the CA1 (41%) and CA3 (54%) regions at 12 h. At 7 days, GABAergic neurons in striatum were lost, suggesting possible pyramidal neuron synapse with striatal GABAergic neurons, and pyramidal neuron damage leading to deafferentation and degeneration of striatal GABAergic neurons. Pre-administration of Nw-nitro-L-arginine-methyl-ester or 7-nitroindazole reduced these effects. These results indicate that NO may modulate kainate-induced neuronal death and locomotion.
Shih
Yang-Hsin
YH
School of Medicine, Taipei Medical University, Taipei, Taiwan.
Lee
Ai-Wei
AW
Huang
Yn-Ho
YH
Ko
Miau-Hwa
MH
Fu
Yu-Show
YS
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D003714:Denervation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D007191:Indazoles / Q000494:pharmacology; D007608:Kainic Acid; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D017072:Neostriatum / Q000378:metabolism / Q000473:pathology*; D009434:Neural Pathways; D009569:Nitric Oxide / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D004791:Enzyme Inhibitors; D018690:Excitatory Amino Acid Agonists; D007191:Indazoles; D009569:Nitric Oxide; D005680:gamma-Aminobutyric Acid; D007608:Kainic Acid; C080122:7-nitroindazole; D019331:NG-Nitroarginine Methyl Ester