title: Transcatheter implantation of intravascular stents for postoperative residual stenosis of peripheral pulmonary artery stenosis.
abstract: This is a prospective study of transcatheter implantation of 11 intravascular stents in 7 patients with status/post (S/P) surgical correction of major cardiovascular lesions. The safety and efficacy of balloon-expandable stents for treatment of peripheral pulmonary artery stenosis (PPAS) is evaluated and analyzed. Although the transcatheter implantation of intravascular stents has been reported as a possible treatment for stenotic peripheral pulmonary arteries, the results of intermediate follow-up studies on patients with S/P surgical correction for residual PPAS need to be evaluated. From June 1998 to December 2001, a total of 15 patients with PPAS having S/P surgery for major cardiovascular lesions were enrolled in this study. Eight of them had redo surgery after complete evaluation and the other 7 patients who might be at higher risk of mortality or morbidity from redo surgery, underwent transcatheter implantation of stents to dilate significant PPAS. Tetralogy of Fallot, S/P total correction, was done in 6 and transposition of great vessels, S/P Jatene operation, was done in 1. There were 10 stents (P 308 Palmaz stent x8 and Intrastent x2) implantation for 10 sites of the stenotic PPAS in these 7 patients, who were aged from 3.6 to 17.3 (10.1 +/- 5.6) years and had body weights ranging from 17 to 72.5 (37.1 +/- 23.0) kg. The narrowest diameter of the stenotic peripheral pulmonary arteries and pressure gradients across the stenosis were measured before and after implantation of stents. A follow-up catheterization and pulmonary angiography was performed 1 year later to evaluate the intermediate efficacy of stents implantation. All the stenotic peripheral pulmonary arteries of these 7 patients had a significant reduction of pressure gradients immediately after the procedure. The narrowest mean diameter of pulmonary arteries increased from 6.7 +/- 3.4 to 11.3 +/- 3.0 mm (p < 0.001), and the mean pressure gradient dropped from 31 +/- 9.9 to 11.4 +/- 4.6 mm Hg (p < 0.001). The follow-up catheterization 1 year later revealed a persistent effect in all but 1 patient. Only a young male presented with a recurrent stenosis with a pressure gradient of > or = 20 mm Hg, which was relieved by redilation with implantation of another stent. There was no immediate or intermediate complication. Transcatheter stent implantation for treatment of a significant residual PPAS after surgical correction of complicated congenital heart disease is a safe and effective procedure. Since children are growing with age, a long-term follow-up study to evaluate the effects and possible problems of stent implantation is mandatory.
authors.affiliation: Department of Pediatrics, Taipei Veterans General Hospital, ROC.
authors.forename: Betau
authors.initials: B
authors.lastname: Hwang
authors.forename: Pi-Chang
authors.initials: PC
authors.lastname: Lee
authors.forename: Yun-Ching
authors.initials: YC
authors.lastname: Fu
authors.forename: Sheng-Ling
authors.initials: SL
authors.lastname: Jan
authors.forename: Chung-Chih
authors.initials: CC
authors.lastname: Kao
authors.forename: Ping-Yao
authors.initials: PY
authors.lastname: Wang
authors.forename: Cheng-Hsiang
authors.initials: CH
authors.lastname: Lien
authors.forename: Zen-Chung
authors.initials: ZC
authors.lastname: Weng
authors.forename: C C Laura
authors.initials: CC
authors.lastname: Meng
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D001835:Body Weight; D002404:Catheterization; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000628:therapy*; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D012008:Recurrence; D012086:Reoperation; D012449:Safety; D015607:Stents; D013771:Tetralogy of Fallot / Q000601:surgery; D013997:Time Factors; D014188:Transposition of Great Vessels / Q000601:surgery