title: Combination of low and high resolution sequences in two orientations for dynamic contrast-enhanced MRI of the breast: more than a compromise.
abstract: The purpose was to combine T1-weighted 3D gradient echo sequences at low and high spatial resolution (and short and longer acquisition time, respectively) in two orientations without compromising signal/time curve analysis and to evaluate the incremental value of assessing architectural features in high resolution images in dynamic contrast-enhanced MR mammography. T1-weighted 3D-FLASH sequences in a 1.5-T scanner (512 x 256 pixel matrix at high resolution; 256 x 128 pixels at low resolution sequences, 72 slices, 1.7-mm slice thickness, TR 8.8 ms, TE 4.5 ms, flip angle 25 degrees) were acquired in a special order during a single investigation. Three observers evaluated architectural features of 36 histopathologically proven lesions using high or low resolution images independently. Architectural features of each lesion were assessed by rating on two three-point scales. Kappa statistics verified the decrease of inter-observer variability. All observers improved assessment of architectural features regarding high resolution images in transversal and coronal orientation (observer A: eight positive, three negative corrections; B: 12/5; C: 16/4). Most positive corrections resulted from improved detection of morphologic criteria of malignancy. Mean inter-observer agreement significantly (P<0.05) increased from "slight" to "moderate" (mean weighted kappa increased from 0.185 to 0.422). This protocol at the charge of slightly enlarged time for measurement offers an elegant way to improve analysis of architectural features in MRM.
authors.affiliation: Department of Radiology, University Medical Centre, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz, Germany. vomweg@radiologie.klinik.uni-mainz.de
authors.forename: Toni W
authors.initials: TW
authors.lastname: Vomweg
authors.forename: Andrea
authors.initials: A
authors.lastname: Teifke
authors.forename: R Peter
authors.initials: RP
authors.lastname: Kunz
authors.forename: Christian
authors.initials: C
authors.lastname: Hintze
authors.forename: Alexander
authors.initials: A
authors.lastname: Hlawatsch
authors.forename: Annett
authors.initials: A
authors.lastname: Kern
authors.forename: Karl F
authors.initials: KF
authors.lastname: Kreitner
authors.forename: Manfred
authors.initials: M
authors.lastname: Thelen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000473:pathology; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000473:pathology; D018276:Carcinoma, Medullary / Q000175:diagnosis / Q000473:pathology; D002648:Child; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015588:Observer Variation; D013382:Subtraction Technique
chemical_list: D003287:Contrast Media