Assessing 24-hour blood glucose patterns in diabetic paitents treated by peritoneal dialysis.
The minute-to-minute effect on blood glucose levels of high-dextrose peritoneal dialysate is not known. We arranged for 7 patients with diabetes, treated by peritoneal dialysis (PD), to wear a continuous glucose monitoring system (CGMS: Medtronic MiniMed, Northridge, CA, U.S.A.). A sensor was inserted subcutaneously into the skin of the patient's abdomen or back to measure glucose in the interstitial fluid. Readings were recorded every 5 minutes for up to 72 hours. The portion of the day during which the patient's blood glucose levels were greater than 180 mg/dL (calculated as a percentage of time) was recorded. Most of the patients participating in the study had elevated levels of glycohemoglobin and hemoglobin A1c, and, for a large percentage of the day, showed blood glucose tracings well above the recommended standards of control. Representative CGMS tracings from patients with type 1 and type 2 diabetes are shown.
Schwing
William D
WD
Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Erhard
Penny
P
Newman
Lynda N
LN
Nodge
Megan M
MM
Czechanski
Barbara J
BJ
Orlin
Susan M
SM
Walden
Sarah M
SM
Behm
Kim
K
Cacho
Carolyn P
CP
Negrea
Lavina A
LA
Siu
David S
DS
Kern
Elizabeth O
EO
Weiss
Miriam F
MF
D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D018670:Monitoring, Ambulatory; D010530:Peritoneal Dialysis
D001786:Blood Glucose; D006442:Glycated Hemoglobin