Antioxidant effects of taurine, vitamin C, and vitamin E on oxidative damage in hippocampus caused by the administration of 3-nitropropionic acid in rats.
The administration of 3-nitropropionic acid increases reactive oxygen species (ROS). Antioxidant defense mechanisms buffer these ROS converting them into non-damaging compounds. Taurine and vitamins C and E are antioxidants that play a role in the defense against cellular damage. This study examines the antioxidant effect of taurine, vitamin C, and vitamin E on acute hippocampal damage caused by 3-NP. Animals treated with 3-NP increased lipid peroxidation levels and astrocytic damage in the hippocampus. Administration of taurine, vitamin C, and vitamin E partially protected from oxidative damage, indicate that while all substances had antioxidant effects, only taurine showed morphological protection in surviving cells.
Rodríguez-Martínez
Erika
E
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma, de México, Mexico.
Rugerio-Vargas
Concepción
C
Rodríguez
Alba I
AI
Borgonio-Pérez
Gabino
G
Rivas-Arancibia
Selva
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001253:Astrocytes / Q000166:cytology; D002452:Cell Count; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D007150:Immunohistochemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009498:Neurotoxins / Q000633:toxicity; D009574:Nitro Compounds; D018384:Oxidative Stress / Q000187:drug effects; D011422:Propionates / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D009498:Neurotoxins; D009574:Nitro Compounds; D011422:Propionates; D014810:Vitamin E; D013654:Taurine; D001205:Ascorbic Acid; C015392:3-nitropropionic acid