Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells.
A synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N-methylbenz[f]indole-4,9-dione (SME-6), showed a potent growth inhibition of a panel of human cancer cell lines. The mechanism of action study revealed that the growth inhibitory effect of SME-6 was highly related to the induction of G2/M cell cycle arrest and apoptosis in human lung cancer cells (A549). These data may provide new information for understanding the mechanisms by benz[f]indole-4,9-diones-mediated antitumor activity.
Lee
Eun-Jin
EJ
College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Korea.
Lee
Hyun-Jung
HJ
Park
Hyen Joo
HJ
Min
Hye-Young
HY
Suh
Myung-Eun
ME
Chung
Hwa-Jin
HJ
Lee
Sang Kook
SK
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D002455:Cell Division / Q000187:drug effects* / Q000502:physiology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D016195:G2 Phase / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008175:Lung Neoplasms; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
C498373:2-amino-3-ethoxycarbonyl-N-methylbenz(f)indole-4,9-dione; D000970:Antineoplastic Agents; D007093:Imidazoles; D009285:Naphthoquinones