title: Electrophysiological evaluation of peripheral and autonomic involvement in leprosy.
abstract: OBJECTIVE
  Motor and sensory nerve conductions, F responses, sympathetic skin responses and R-R interval variations (RRIV) were studied to determine the type of peripheral neuropathy among patients with leprosy.
  
  
  METHODS
  Twenty-nine consecutive patients with leprosy (25 male, 4 female) hospitalized in the "Istanbul Leprosy Hospital" between January - December, 1999 were included in this study. Ten patients had borderline lepromatous leprosy, and 19 had lepromatous leprosy. None of the patients studied had the tuberculoid form. The mean age was 55 +/- 12 years. The control group consisted of 30 (26 male, 4 female) healthy volunteers (mean age: 58.1 +/- 7.8 years). All subjects included in the study underwent neurological examination and electrophysiological evaluation. Standard procedures were performed for evaluating sensory and motor conduction studies. Motor studies were carried out on both left and right median, ulnar, tibial and common peroneal nerves while median, ulnar, sural and superficial peroneal nerves were examined for sensory studies. Sympathetic skin response recordings on both hands and RRIV recordings on precordial region were done in order to evaluate the autonomic involvement.
  
  
  RESULTS
  The lower extremity was found to be more severely affected than the upper, and sensory impairment predominated over motor. Of 58 upper limbs examined, no sympathetic skin responses was recorded in 46 (79.3%). Compared with the controls, the RRIVs of the leprosy patients were found to be reduced during both resting and deep forced hyperventilation.
  
  
  CONCLUSIONS
  Our results indicate that leprosy causes a predominantly axonal polyneuropathy that is more severe in the lower extremities. Sensory nerve damage is accompanied by autonomic involvement.
authors.affiliation: Bakirkoy State Hospital for Neurological and Psychiatric Diseases, Neurology Department, Istanbul, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Soysal
authors.forename: Turan
authors.initials: T
authors.lastname: Atay
authors.forename: Tacettin
authors.initials: T
authors.lastname: Ozu
authors.forename: Baki
authors.initials: B
authors.lastname: Arpaci
mesh_terms: D000328:Adult; D000344:Afferent Pathways / Q000503:physiopathology; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000382:microbiology* / Q000503:physiopathology; D004525:Efferent Pathways / Q000503:physiopathology; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007918:Leprosy / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D020423:Median Neuropathy / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology; D008875:Middle Aged; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000382:microbiology* / Q000503:physiopathology; D020427:Peroneal Neuropathies / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology; D020429:Tibial Neuropathy / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology; D020424:Ulnar Neuropathies / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology