Hitting their targets: an emerging picture of E2F and cell cycle control.
Understanding the role of transcription factors in governing cell-cycle progression in mammalian cells has been hindered until recently by a relative lack of genetic and genomic approaches. New approaches that harness the power of ChIP and combine this technique with DNA microarrays and bioinformatics have identified direct, physiological targets and have significantly altered our view of the E2F transcription factor that is known to play a role in regulation of cell-cycle progression. Further, the identification of additional E2F family members and factors that function in concert with E2F have considerably expanded our picture of the genetic programs that are governed by this essential regulatory factor.
Blais
Alexandre
A
Department of Pathology, MSB 504, New York University School of Medicine and NYU Cancer Institute, 550 First Avenue, New York, New York 10016, USA. brian.dynlacht@med.nyu.edu
Dynlacht
Brian David
BD
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000145:classification / Q000378:metabolism*; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000145:classification / Q000378:metabolism*; D050684:E2F Transcription Factors; D006801:Humans; D013379:Substrate Specificity; D014157:Transcription Factors / Q000145:classification / Q000378:metabolism*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D014157:Transcription Factors