title: Functional imaging in Lhermitte-Duclose disease.
abstract: OBJECTIVE
  A comprehensive metabolic characterization of a patient with dysplastic gangliocytoma of the cerebellum or Lhermitte-Duclos Disease (LDD) is presented.
  
  
  METHODS
  Assessment using 2-deoxy-2-[18F]fluoro-D-glucose (FDG), carbon-11-labeled methionine (11C-MET), carbon-11-labeled choline (11C-Choline) positron emission tomography (PET), and 1H-proton magnetic resonance spectroscopy (MRS) was carried out in a 30-year-old Caucasian woman.
  
  
  RESULTS
  FDG-PET revealed hypermetabolism of the tumor. 11C-MET-PET revealed moderate uptake and 11C-Choline showed no uptake. 1H-MRS demonstrated an elevated level of lactate and decreased levels of choline (Cho) and myoinositol.
  
  
  CONCLUSIONS
  Functional imaging in LDD reflects the dual pathological features of neoplasm and hamartoma.
authors.affiliation: Wallace-Kettering Neurosciences Institute, Kettering Medical Center, OH 45429, USA.
authors.forename: Madakasira V
authors.initials: MV
authors.lastname: Padma
authors.forename: Martin
authors.initials: M
authors.lastname: Jacobs
authors.forename: Pam
authors.initials: P
authors.lastname: Sequeira
authors.forename: Mehdi
authors.initials: M
authors.lastname: Adineh
authors.forename: Martin
authors.initials: M
authors.lastname: Satter
authors.forename: Gary
authors.initials: G
authors.lastname: Kraus
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Mantil
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005729:Ganglioneuroma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D049268:Positron-Emission Tomography; D011859:Radiography
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18