title: Ischemic stroke: "acidotoxicity" is a perpetrator.
abstract: Ischemic stroke is a devastating neurological disease. The responsible mechanisms are not completely understood. In this issue of Cell, Xiong et al. (2004) elucidate a molecular mechanism by which acidosis damages the brain during ischemia.
authors.affiliation: Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Yangzhong
authors.initials: Y
authors.lastname: Huang
authors.forename: James O
authors.initials: JO
authors.lastname: McNamara
mesh_terms: D000138:Acidosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D018698:Glutamic Acid / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D009410:Nerve Degeneration / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D017470:Receptors, Glutamate / Q000187:drug effects / Q000378:metabolism; D020521:Stroke / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D017470:Receptors, Glutamate; D018698:Glutamic Acid