title: Affinity mass spectrometry from a tailored porous silicon surface.
abstract: The development of chemically stable porous silicon (pSi) materials for DIOS (Desorption/Ionization on Silicon) mass spectrometry, covalent linkers cleaved in the DIOS laser pulse, and efficient methods for bond formation to immobilized species, allows for on-chip affinity purification and mass detection.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
authors.forename: Jun-Cai
authors.initials: JC
authors.lastname: Meng
authors.forename: Gary
authors.initials: G
authors.lastname: Siuzdak
authors.forename: M G
authors.initials: MG
authors.lastname: Finn
mesh_terms: D016062:Porosity; D011506:Proteins / Q000032:analysis; D012825:Silicon / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013499:Surface Properties
chemical_list: D011506:Proteins; D012825:Silicon