title: [Mucinous cholangiocarcinoma associated with Clonorchis sinensis infestation: a case report].
abstract: Mucinous cholangiocarcinoma, characterized by large quantities of mucin production, is a rare subtype of peripheral cholangiocarcinoma and usually shows rapid progression and a fatal outcome. We report here a case of mucinous cholangiocarcinoma in a 69 year-old man, who was infected with Clonorchis sinensis. Histologically, the tumor was an adenocarcinoma with extensive intracellular and extracellular mucin production, up to 70% of the tumor mass and there was frequent lymphovascular invasion of the tumor cells. The liver adjacent to the mass contained eggs of Clonorchis sinensis in the bile duct lumen and showed ductal epithelial hyperplasia, mucinous metaplasia and adenomatous proliferation of intramural glands. The patient was treated with a right hepatectomy. Four months after the surgery, the tumor recurred in the soft tissue of the right flank.
authors.affiliation: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyo Sup
authors.initials: HS
authors.lastname: Shim
authors.forename: Beom Jin
authors.initials: BJ
authors.lastname: Lim
authors.forename: Myeong-Jin
authors.initials: MJ
authors.lastname: Kim
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Lee
authors.forename: Chanil
authors.initials: C
authors.lastname: Park
authors.forename: Young Nyun
authors.initials: YN
authors.lastname: Park
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications* / Q000378:metabolism; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000150:complications* / Q000378:metabolism; D003003:Clonorchiasis / Q000150:complications*; D006801:Humans; D008297:Male; D009077:Mucins / Q000378:metabolism
chemical_list: D009077:Mucins