Enterococcal peptide sex pheromones: synthesis and control of biological activity.
The enterococcal pheromone-inducible plasmids such as pCF10 represent a unique class of mobile genetic elements whose transfer functions are induced by peptide sex pheromones. These pheromones are excreted by potential recipient cells and detected by plasmid-containing donor cells at the cell surface, where the pheromone is imported and signals induction of the plasmid transfer system. Pheromone is processed from a chromosomally encoded lipoprotein and excreted by both the donor and recipient cells, but a carefully controlled detection system prevents a response to self-pheromone while still allowing an extremely sensitive response to exogenous pheromone.
Chandler
Josephine R
JR
Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Bldg., 420 Delaware Street SE, Minneapolis, MN 55455-0312, USA.
Dunny
Gary M
GM
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry; D001665:Binding Sites; D016983:Enterococcus / Q000378:metabolism*; D013293:Enterococcus faecalis / Q000378:metabolism; D008074:Lipoproteins / Q000737:chemistry; D008954:Models, Biological; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009876:Operon; D010455:Peptides / Q000737:chemistry; D010675:Pheromones / Q000737:chemistry; D010957:Plasmids / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012724:Sex Attractants / Q000737:chemistry*
D001426:Bacterial Proteins; D008074:Lipoproteins; D010455:Peptides; D010675:Pheromones; D012724:Sex Attractants; C082576:traB protein, Bacteria