[Novel matrix metalloproteinases in cycling endometrium].
OBJECTIVE
To examine the expression pattern of some novel matrix metalloproteinases (MMPs) in cycling endometrium.


METHODS
Experimental study.


METHODS
Department of Obstetrics and Gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.


METHODS
We studied MMP-12, -16, -17, -19 and -26 mRNA in 39 normal endometrial samples obtained across the menstrual cycle. Based on histological examination, all specimens were classified according to an ideal 28 day menstrual cycle as early (n=8), mid (n=6) and late (n=7) proliferative phase, early (n=4), mid (n=4) and late (n=8) secretory phase and menstrual (n=3) phase. Cycle variation was examined in frozen samples using in situ hybridization.


RESULTS
Three distinct pattern of MMP mRNA expression were detected in cycling endometrium. MMP-12 was expressed predominantly in perimenstrual period, MMP-16, -17 and 19 were expressed throughout the cycle and MMP-26 was found to be maximal in periovulatory period.


CONCLUSIONS
Different endometrial expression patterns of novel MMPs during menstrual cycle may indicate their specific roles for menstruation, endometrial growth and remodelling and implantation.
Pilka
R
R
Gynekologicko-porodnická klinika FN a LF UP, Olomouc.
Kudela
M
M
Hansson
S
S
Casslén
B
B
D000328:Adult; D004717:Endometrium / Q000201:enzymology*; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008597:Menstrual Cycle / Q000378:metabolism*; D008875:Middle Aged
D020782:Matrix Metalloproteinases
Nové matrix metaloproteinázy v cyklickém endometriu.