Cytochrome P-450 catalytic activity and isoform composition following liver denervation in old male rats.
A study was made concerning the role of adrenergic and cholinergic neural regulation in the functional activity of enzymes of microsomal oxidation in the liver. Experiments were performed on adult and old rats using surgical denervation of liver (vagotomy and sympathotomy). The results obtained showed changes that occurred in the monooxygenase activity (aminopyrine demethylase and aniline hydroxylase), as well as in the isoform composition and inductive synthesis of cytochrome P-450. The neural control over liver detoxication function was found to weaken in old age.
Frolkis
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Inst. of Gerontology, AMS USSR, Vyshgorodskaya St. 67, 252655 Kiev-114, USSR.
Paramonova
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GI