[Changes in lipid peroxidation in psoriasis].
Changes of the lipid peroxidation processes (LP) in the skin (corneal layer of the epidermis) and in blood, as observed in 61 patients with local psoriasis at the progressing stage and in 55 patients with local psoriasis at remission, were investigated. The quantity of diene conjugates, ketodienes, and of conjugate trienes in the heptanoic and isopropanol phases was decreasing both in the affected and intact skins versus the controls. The test based on thiobarbituric acid (TBA) was used to establish that the content of the TBA-positive products was also decreasing. The examined values did not reach the control figures at remission. The content of the studied indices in blood was reliably higher than the control figures in all lipid extract phases at exacerbation of the dermal affection; it did not decrease after the main dermal lesion was eliminated. The correlation analysis revealed the presence of correlations between the studied parameters in blood and skin, which were changing with respect to a stage of the dermal affection.
Khyshiktuev
B S
BS
Fal'ko
E V
EV
D000328:Adult; D004817:Epidermis / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D011565:Psoriasis / Q000097:blood / Q000378:metabolism*
Izmeneniia perekisnogo okisleniia lipidov pri psoriaze.