title: A patient with Glanzmann's thrombasthenia for emergent abdominal surgery.
abstract: Glanzmann's thrombasthenia is a rare autosomal recessive disease characterized by potentially major mucocutaneous complications and nose bleeds. It is considered hazardous for these surgical patients to conceive, with a high risk of urgent surgery. The treatment of bleeding or prevention of hemorrhage for surgery or invasive procedures is based on platelet transfusion. However, platelet transfusions may be responsible for the development of alloimmunization, with a high risk of future platelet refractoriness. We report a surgical case of Glanzmann's thrombasthenia complicated by nasopharyngeal bleeding and managed with platelet transfusions, recombinant activated factor VII, and postoperative airway management in the intensive care unit.
authors.affiliation: Department of Anesthesiology and Reanimation, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
authors.forename: Halil Ibrahim
authors.initials: HI
authors.lastname: Uzunlar
authors.forename: Ahmet
authors.initials: A
authors.lastname: Eroglu
authors.forename: Ahmet Can
authors.initials: AC
authors.lastname: Senel
authors.forename: Habib
authors.initials: H
authors.lastname: Bostan
authors.forename: Nesrin
authors.initials: N
authors.lastname: Erciyes
mesh_terms: D015746:Abdominal Pain / Q000601:surgery; D000328:Adult; D000768:Anesthesia, General; D001062:Appendectomy; D001065:Appendix / Q000601:surgery*; D001760:Bleeding Time; D003422:Critical Care; D004844:Epistaxis / Q000628:therapy; D005167:Factor VII / Q000627:therapeutic use; D005734:Gangrene / Q000601:surgery*; D006801:Humans; D007813:Laparotomy; D008297:Male; D010983:Plateletpheresis; D011994:Recombinant Proteins / Q000627:therapeutic use; D013915:Thrombasthenia / Q000150:complications*
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII