title: Decrease in measles virus-specific CD4 T cell memory in vaccinated subjects.
abstract: Since the licensure and generalization of an effective measles virus (MV) vaccine 41 years ago, antibody levels have been used as correlates of immunity. The long-lived MV-specific antibody response has been studied intensely, but the dynamics of MV-specific T cell immunity over time have not been well characterized. We thus characterized the profiles of MV vaccine-induced antigen-specific T cells over time since vaccination. In a cross-sectional study of healthy subjects with a history of MV vaccination, we found that MV-specific CD4 and CD8 T cells could be detected up to 34 years after vaccination. The levels of MV-specific CD8 T cells and MV-specific IgG remained stable, whereas the level of MV-specific CD4 T cells decreased significantly in subjects who had been vaccinated >21 years earlier. These results show that MV-specific T cell immunity after vaccination is long lasting and reveal different dynamics between CD4 and CD8 cells after vaccination.
authors.affiliation: Division of Virology, Department of Neuropharmacology, Scripps Research Institute, San Diego, California, USA. dsauzanne@clinic.ub.cs.
authors.forename: Denise
authors.initials: D
authors.lastname: Naniche
authors.forename: Michel
authors.initials: M
authors.lastname: Garenne
authors.forename: Chris
authors.initials: C
authors.lastname: Rae
authors.forename: Marianne
authors.initials: M
authors.lastname: Manchester
authors.forename: Richard
authors.initials: R
authors.lastname: Buchta
authors.forename: Stephanie K
authors.initials: SK
authors.lastname: Brodine
authors.forename: Michael B A
authors.initials: MB
authors.lastname: Oldstone
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood; D007156:Immunologic Memory; D018655:Lymphocyte Count; D008297:Male; D008457:Measles / Q000276:immunology*; D008458:Measles Vaccine / Q000276:immunology*; D018103:Morbillivirus / Q000276:immunology* / Q000302:isolation & purification; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D008458:Measles Vaccine