Molecular makeup of HIV-1 envelope protein.
A broad range of structural, functional, and immunological similarities between HIV-1 gp120 and human proteins, especially those participating in immune responses, highlight gp120 as a pleiotropic protein that can in different ways affect many important functions of the human immune system. Here we described some of these properties of HIV-1 gp120 that represent the main obstacle in the development of effective and safe AIDS vaccine.
Veljkovic
Veljko
V
Center for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, Belgrade, Yugoslavia. veljko01@hotmail.com
Veljkovic
Nevena
N
Metlas
Radmila
R
D024142:Collagen Type VI / Q000737:chemistry; D003429:Cross Reactions; D005803:Genes, Immunoglobulin; D015699:HIV Envelope Protein gp120 / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D015497:HIV-1 / Q000737:chemistry*; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000737:chemistry / Q000235:genetics; D007376:Interleukin-2 / Q000096:biosynthesis; D014660:Vasoactive Intestinal Peptide / Q000737:chemistry
D024142:Collagen Type VI; D015699:HIV Envelope Protein gp120; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D007376:Interleukin-2; D014660:Vasoactive Intestinal Peptide