Pseudo-pseudo-obstruction: lessons in diagnosis and management.
Chronic intestinal pseudo-obstruction (CIP) has been defined as a rare and severe, disabling disorder, which is characterised by recurring episodes or continuous symptoms and signs of bowel obstruction, including radiological features of obstruction. It is suggested that the diagnosis should be broadened to include patients with severe gastrointestinal symptoms who do not have radiological features of obstruction but who have manometric features of CIP and/or have demonstrable end organ list of pathological features described in CIP. A case of pseudo-pseudo-obstruction is described in this issue of the Journal. Originally the patient was thought to have CIP, and a mechanical cause of obstruction was suspected based on small intestine manometric features, suggesting a distal mechanical obstruction and a worsening of symptoms when treated with a prokinetic agent. As patients with CIP can develop mechanical obstruction and episodes of mechanical obstruction can mimic CIP, small intestine manometry and trials of prokinetic therapy should be undertaken in all difficult cases of obstruction and particularly in patients with documented CIP.
Silk
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Department of Gastroenterology and Nutrition, Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK.
D002908:Chronic Disease; D020117:Cisapride / Q000009:adverse effects / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D007421:Intestine, Small / Q000503:physiopathology; D010535:Laparoscopy; D008365:Manometry; D000267:Tissue Adhesions / Q000175:diagnosis / Q000601:surgery
D005765:Gastrointestinal Agents; D020117:Cisapride