Evolutionary origin of the Jiv90 gene of Pestivirus.
Phylogenetic analyses were used to test the hypothesis that the Jiv90 insert in the genomes of Pestivirus species originated by horizontal transfer from their hosts (mammals in the order Artiodactyla). The results supported this hypothesis because the Jiv90 insert clustered with the corresponding domains of mammalian Jiv proteins and closer to artiodactyl than to rodent or primate genes. A phylogeny of Pestivirus genotypes showed that the Jiv90 insert occurred only in one clade (Pestivirus Type 1), although numerous members of this clade lacked the insert. This pattern is probably most easily explained on the hypothesis that the insert occurred in the common ancestor of the Type 1 clade and that it has been subsequently lost independently by several members of the clade.
Hughes
Austin L
AL
Department of Biological Sciences, University of South Carolina, Coker Life Sciences Bldg., 700 Sumter St., Columbia, SC 29208, USA. austin@biol.sc.edu
D000595:Amino Acid Sequence; D000818:Animals; D001188:Artiodactyla / Q000821:virology; D001483:Base Sequence; D003062:Codon; D019143:Evolution, Molecular; D017353:Gene Deletion; D022761:Gene Transfer, Horizontal; D016679:Genome, Viral; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D010576:Pestivirus / Q000235:genetics*; D010802:Phylogeny; D020815:Polyproteins / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
D003062:Codon; D020815:Polyproteins