Application of directed orthometalation toward the synthesis of aryl siloxanes.
A selection of ortho-substituted aryl siloxanes have been prepared by directed orthometalation protocols. These siloxanes can be prepared in high yields and purity by use of a diverse selection of ortho-directing groups and electrophilic siloxane derivatives. The siloxanes are employed in palladium-catalyzed cross-coupling reactions with aryl bromides to generate unsymmetrical ortho-substituted biaryls in good to excellent yields.
Seganish
W Michael
WM
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
DeShong
Philip
P
D002384:Catalysis; D008956:Models, Chemical; D015394:Molecular Structure; D010165:Palladium; D012833:Siloxanes / Q000138:chemical synthesis*
D012833:Siloxanes; D010165:Palladium