The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation.
The Wnt signaling pathway plays essential roles in embryogenesis of higher eukaryotes from diploblastic, radially symmetrical cnidarians to mice and humans. Whereas studies in model organisms such as Drosophila and Xenopus continue to elucidate how the Wnt pathway is regulated, studies of mouse mutants and cultured mammalian cells start to reveal how the Wnt pathway controls development and differentiation in mammals. Here we review some of the recent progresses in our understanding of the Wnt pathway. We focus on how this pathway, through regulating transcription of its downstream target genes, specifies pattern formation during mammalian embryogenesis and functions in the differentiation and maintenance of stem cells both in vivo and in vitro.
Wang
Jianbo
J
Department of Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Dr., MC 0627, La Jolla, California 92093-0627, USA.
Wynshaw-Boris
Anthony
A
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002454:Cell Differentiation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D013997:Time Factors; D051153:Wnt Proteins
D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins