The herbal prescription youkongdan modulates rodent memory, ischemic damage and cortical mRNA gene expression.
The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and alphaB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice.
Shin
Joon Shik
JS
Jaseng Research Institute of Biotechnology and Bioscience, Seoul, Korea.
So
Chang Sok
CS
Kim
Young Ock
YO
Ahn
Duk Kyun
DK
Sharman
Kaizhi G
KG
Sharman
Edward H
EH
D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002545:Brain Ischemia / Q000517:prevention & control*; D002452:Cell Count / Q000379:methods; D002540:Cerebral Cortex / Q000187:drug effects*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D019587:Dietary Supplements; D004347:Drug Interactions; D051766:Early Growth Response Protein 1; D000091342:Endoplasmic Reticulum Chaperone BiP; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics / Q000378:metabolism; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000072105:Superoxide Dismutase-1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins; C000717248:Hspa5 protein, mouse; D017874:Immediate-Early Proteins; D018832:Molecular Chaperones; D018727:Muscarinic Antagonists; D010936:Plant Extracts; D028321:Plant Preparations; D012333:RNA, Messenger; D014157:Transcription Factors; C493326:youkongdan; D012601:Scopolamine; C000606291:Sod1 protein, mouse; C000606292:Sod1 protein, rat; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D020929:Mitogen-Activated Protein Kinase Kinases