Pulse wave velocity as an indicator of arteriosclerosis in hemodialysis patients.
Studies were performed to examine whether pulse wave velocity (PWV) is a useful indicator of arteriosclerosis in hemodialysis (HD) patients. In total, 72 patients were enrolled. Annual changes in PWV were compared to clinical parameters and therapeutic maneuvers. PWV increased in diabetic patients faster than non-diabetics (35 +/- 10 cm/s/month versus 10 +/- 4 cm/s/month, P < 0.05). Changes in PWV showed strong correlations to triglyceride level exposed during observation period (r = 0.50, P < 0.05) and HD duration (r = 0.46, P < 0.05). In addition, we found that PWV of some patients decreased (regressors), while the others increased (non-regressors). Regressors more frequently received combined treatment with angiotensin blockade and lipid-lowering drugs or vitamin E-coated dialyzers than non-regressors (P < 0.05). Our data demonstrate that PWV is useful as a marker of arteriosclerosis in HD patients. Furthermore, the present results suggest that combined treatment with both angiotensin inhibition and lipid-lowering drugs or vitamin E-coated membrane would slow the progression of arteriosclerosis in HD patients.
Takenaka
Tsuneo
T
Department of Medicine, Nephrology Section, Saitama Medical College, 38 Moro-hongo, Moroyama, Iruma, Saitama 350-0495, Japan.
Kobayashi
Kenji
K
Suzuki
Hiromichi
H
D000975:Antioxidants / Q000494:pharmacology; D001158:Arteries / Q000502:physiology; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000503:physiopathology*; D001794:Blood Pressure; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D006949:Hyperlipidemias; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D014655:Vascular Resistance; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D000960:Hypolipidemic Agents; D014810:Vitamin E