title: Quantitation of red cell-bound immunoglobulins and complement in lymphoma patients.
abstract: Quantitative ELISA may be useful for determining the amount of red blood cell (RBC)-associated immunoglobulins (Igs) in patients with autoimmune hemolytic anemia (AIHA). In idiopathic AIHA, there is about 20 times more RBC-associated IgG and complement than in normal persons. In patients with low-grade lymphomas (particularly, B-CLL and splenic marginal zone lymphoma) autoimmune hemolysis is a component of their anemia. In high-grade malignant lymphomas (i.e, diffuse large B-cell lymphoma and peripheral T-cell lymphoma), as well as in Hodgkin's disease, autoimmune hemolysis contributes little, if any, anemia. The quantitative ELISA for RBC-associated IgG and complement is useful for following the effects of treatment in patients with immune hemolysis.
authors.affiliation: Hematology/Oncology Dept., Children's Hospital Los Angeles, 4650 Sunset Blvd., #57, Los Angeles, CA 90027, USA.
authors.forename: M
authors.initials: M
authors.lastname: Podberezin
authors.forename: A
authors.initials: A
authors.lastname: Levina
authors.forename: L
authors.initials: L
authors.lastname: Romanova
authors.forename: O
authors.initials: O
authors.lastname: Margolin
authors.forename: O
authors.initials: O
authors.lastname: Nasibov
authors.forename: A V
authors.initials: AV
authors.lastname: Pivnik