title: EPR evaluation of the antiradical activity of wines containing high concentrations of resveratrol.
abstract: The ability of two samples of red wine with different resveratrol concentrations to inhibit hydroxyl radicals (*OH) produced by a Fenton-type reaction was assessed using the method of electronic paramagnetic resonance (EPR). One sample was an autochthonous wine, Uvalino, which has a very high resveratrol concentration; the second was another red wine with a much lower resveratrol concentration. The ability of the sample of Uvalino wine to obstruct hydroxyl radicals was evident, but it wasn't much better than the ability of the sample of wine with a lower resveratrol concentration. The resveratrol concentration of wine is an important factor for the inhibition of the formation of free radicals, especially hydroxyl radicals; however, it is not the only one responsible for this property of wine. Resveratrol concentration can act synergically with other factors, such as polyphenols, which are also contained in wine and have antioxidant properties.
authors.affiliation: Department of Pharmacology, Chemotherapy and Clinical Toxicology, Faculty of Medicine, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bertelli
authors.forename: M
authors.initials: M
authors.lastname: Falchi
authors.forename: R
authors.initials: R
authors.lastname: Lo Scalzo
authors.forename: R
authors.initials: R
authors.lastname: Morelli
mesh_terms: D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004357:Drug Synergism; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000009:adverse effects / Q000032:analysis / Q000037:antagonists & inhibitors*; D007558:Italy; D010636:Phenols / Q000032:analysis / Q000494:pharmacology; D059808:Polyphenols; D000077185:Resveratrol; D013267:Stilbenes / Q000032:analysis* / Q000494:pharmacology; D027843:Vitis / Q000737:chemistry / Q000145:classification; D014920:Wine / Q000032:analysis* / Q000145:classification
chemical_list: D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D010636:Phenols; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol