[Role of ghrelin in the pathophysiology of eating behaviour].
Ghrelin, the endogenous ligand for GHS-R, was isolated from rat stomach, although other tissues exist expressing ghrelin, such as pituitary, hypothalamus, placent, ovary, testes, etc. It was showed that ghrelin is implicated in GH secretion, in vivo and in vitro. There are direct evidences that proof that ghrelin administration induces GH secretion. There are in vivo data, showing ghrelin as a most potent GH secretor than GHRH. Evidences exist of ghrelin actions in the regulation of food intake and energy homeostasis. Ghrelin has a clear role in the differents pathologies such as obesity, anorexia and bulimia.
Seoane
L M
LM
Laboratorio de Endocrinología Molecular, Departamento de Medicina, Complejo Hospitalario Universitario de Santiago de Compostela.
Lage
M
M
Al-Massadi
O
O
Diéguez
C
C
Casanueva
F F
FF
D054369:Agouti-Related Protein; D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D005753:Gastric Mucosa / Q000378:metabolism; D054439:Ghrelin; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000502:physiology; D009478:Neuropeptide Y / Q000502:physiology; D036361:Peptide Hormones / Q000494:pharmacology / Q000502:physiology*; D011506:Proteins / Q000502:physiology; D051381:Rats; D011917:Rats, Inbred Lew; D011922:Rats, Mutant Strains
D054369:Agouti-Related Protein; D054439:Ghrelin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D009478:Neuropeptide Y; D036361:Peptide Hormones; D011506:Proteins; D013006:Growth Hormone
Papel de la ghrelina en la fisiopatología del comportamiento alimentario.