Serum ascorbic acid concentrations in previously unsupplemented greyhounds after administration of a single dose of ascorbic acid intravenously or per os.
Plasma vitamin C concentrations (mean + SD) were measured after a large (1 g) dose of vitamin C was administered orally or intravenously to each of four trained greyhounds in a randomized cross-over design. Concentrations increased (p<0.05) for 2 h but returned to baseline by 6 h after supplementation. Peak concentrations were greater (p<0.01) after intravenous than oral administration (6.1+/-1.2 vs. 0.54+/-0.23 mg/dl). This suggests that vitamin C must be administered many times daily to maintain plasma concentrations above normal.
Scott
K C
KC
Department of Small Animal Clinical Sciences and the Center for Veterinary Sports Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Hill
R C
RC
Lewis
D D
DD
Gronwall
R
R
Sundstrom
D A
DA
Jones
G L
GL
Harper
J
J
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000097:blood*; D018592:Cross-Over Studies; D004285:Dogs / Q000097:blood*; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D011897:Random Allocation
D000975:Antioxidants; D001205:Ascorbic Acid