Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells.
The cytotoxicity of two plant hormone compounds, kinetin and kinetin riboside, was studied on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The concentration of inhibitor required to reduce cell growth to 50% was determined for these molecules. Kinetin riboside was shown to only act on M4 Beu human and B16 murine melanoma cells at low concentration (1.5 and 0.2 microM). On mice with leukaemia P388, this product has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg. Kinetin riboside was also shown to have a cytotoxic effect on plant tumour cells (crown-gall).
Griffaut
Bernard
B
EA 3296 ERTAC, Physiologie et Génétique Végétales, Université Blaise-Pascal, 24 avenue des Landais, 63177 Aubière Cedex, France.
Bos
Romain
R
Maurizis
Jean-Claude
JC
Madelmont
Jean-Claude
JC
Ledoigt
Gérard
G
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D007701:Kinetin; D008297:Male; D008546:Melanoma, Experimental; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D009705:Nucleosides / Q000494:pharmacology*; D010937:Plant Growth Regulators / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects
D000970:Antineoplastic Agents; D009705:Nucleosides; D010937:Plant Growth Regulators; D000225:Adenine; D007701:Kinetin