title: Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy.
abstract: Cytokines, having central functions in immunological and inflammatory process, are always expected to play important roles in the pathogenesis of various diseases, such as asthma. Genetic polymorphisms of those cytokine and cytokine receptor genes are the focus of genetic association studies. In an effort to identify gene(s) whose variant(s) are involved in the development of asthma, we examined the genetic effects of 19 single nucleotide polymorphisms in eight cytokine and cytokine receptor genes, including IL1A, IL1B, IL2, IL3, IL4, IL8, IL10, and IL5RA, on asthma and atopy. Nineteen single nucleotide polymorphisms in eight cytokine and cytokine receptor genes were genotyped using the single-base extension method in a Korean asthma cohort (n = 723). Logistic regression and multiple regressions were used for statistical analyses controlling for smoking, age, and gender as covariables. Genetic association analysis of polymorphisms revealed that one exonic (exon 1), IL3 + 79T > C ( Ser27Pro), showed significant association with the risk of asthma and atopy. The Pro allele had shown dominant and protective effects on development of asthma in nonatopic subjects (P = 0.002) and also showed significant association with the risk of atopy in normal control subjects (P = 0.007). This information about the genetic association of important genes with asthma might provide valuable insights into strategies for the pathogenesis of asthma and atopy.
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-gu, Seoul, 110-834, South Korea.
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-gu, Seoul, 110-834, South Korea.
authors.forename: Lyoung Hyo
authors.initials: LH
authors.lastname: Kim
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-gu, Seoul, 110-834, South Korea.
authors.forename: Yoo Hyun
authors.initials: YH
authors.lastname: Choi
authors.affiliation: Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
authors.forename: June-Hyuk
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
authors.forename: Taiyoun
authors.initials: T
authors.lastname: Rhim
authors.affiliation: Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
authors.forename: Young Mok
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
authors.forename: Soo-Taek
authors.initials: ST
authors.lastname: Uh
authors.affiliation: Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
authors.forename: Hae-Sim
authors.initials: HS
authors.lastname: Park
authors.affiliation: Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
authors.forename: Byoung Whui
authors.initials: BW
authors.lastname: Choi
authors.affiliation: Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
authors.forename: Soo-Jong
authors.initials: SJ
authors.lastname: Hong
authors.affiliation: Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea. schalr@schbc.ac.kr.
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Park
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-gu, Seoul, 110-834, South Korea.
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000235:genetics*; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018121:Receptors, Cytokine / Q000235:genetics; D012307:Risk Factors
chemical_list: D017931:DNA Primers; D007377:Interleukin-3; D018121:Receptors, Cytokine