Blood gammadelta T cells, Campylobacter jejuni, and GM1 titers in Guillain-Barré syndrome.
The gammadelta T cells participate in microbial defense, are prevalent in intestinal epithelia, and are activated in autoimmune diseases. We studied whether peripheral blood gammadelta cells and gammadelta subsets are increased in Guillain-Barré syndrome (GBS) and whether elevations are associated with Campylobacter jejuni infection or GM1 elevations. In 20 GBS patients, we performed serial flow cytometry studies of blood gammadelta, Vdelta1, and Vdelta2 cells (+/- CD8+), C jejuni, and ganglioside titers. There was no significant difference in median gammadelta T-cell percentages between GBS patients and controls at onset and at convalescence. However, 5 patients had marked Vdelta1/CD8+ elevations. Elevated Vdelta1 or Vdelta1/CD8+ cells occurred in 3 of 6 patients with C jejuni or GM1 titer elevations. A minority of GBS patients have elevations of Vdelta1/CD8+ cells, possibly associated with elevated C jejuni or GM1 titers. The gammadelta T cells may have a cytotoxic (or suppressor) role in the disease.
Scelsa
Stephen N
SN
Department of Neurology, Beth Israel Medical Center, New York, NY, USA. sscelsa@bethisraelny.org
Ghali
Violette
V
Herskovitz
Steven
S
Bieri
Phyllis
P
Shank
Deborah L
DL
MacGowan
Daniel D J
DD
Liau
Sally
S
D000907:Antibodies, Bacterial / Q000032:analysis; D000911:Antibodies, Monoclonal; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002169:Campylobacter Infections / Q000150:complications* / Q000378:metabolism; D016123:Campylobacter jejuni; D004594:Electrophysiology; D005434:Flow Cytometry; D016537:Gangliosidosis, GM1 / Q000378:metabolism*; D020275:Guillain-Barre Syndrome / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D018655:Lymphocyte Count; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D016692:Receptors, Antigen, T-Cell, gamma-delta