title: Treatment and follow-up of persistent granulomatous cheilitis with intralesional steroid and metronidazole.
abstract: Granulomatous cheilitis (GC) is a chronic edema which frequently affects the upper lip due to granulomatous inflammation. Its etiology is currently unknown. This rare disease is generally accompanied by Melkersson-Rosenthal syndrome (MRS), characterized by scrotal tongue, orofacial edema and facial paralysis. However, it is also known to develop only with orofacial edema. Granulomatous cheilitis is a difficult disease to treat because of recurrences. There are contradictory reports about the results of treatment without surgical intervention and the rates of recurrence. Our case was a 57-year-old female patient who was characterized by orofacial edema only. The edema and erythema had persisted for 1 year before admission. In the present case, application of intralesional corticosteroid treatment as a total of three injections over 3 consecutive months (one injection per month) and the accompanying metronidazole treatment brought about successful results. No recurrence was observed in the follow-up.
authors.affiliation: Department of Dermatology, Firat University Faculty of Medicine, Elazig, Turkey. basakkc@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Coskun
authors.forename: Y
authors.initials: Y
authors.lastname: Saral
authors.forename: D
authors.initials: D
authors.lastname: Cicek
authors.forename: N
authors.initials: N
authors.lastname: Akpolat
mesh_terms: D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008046:Lip / Q000473:pathology; D008556:Melkersson-Rosenthal Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D012008:Recurrence
chemical_list: D005938:Glucocorticoids; D008795:Metronidazole