title: Efficacy and tolerability of mirtazapine and sertraline in Korean veterans with posttraumatic stress disorder: a randomized open label trial.
abstract: BACKGROUND
  The aim of this study was to investigate the potential use of mirtazapine in Korean veterans diagnosed with PTSD, by comparing it with sertraline, a drug approved for use in PTSD in the USA.
  
  
  METHODS
  Efficacy was evaluated by the clinician administered PTSD scale (CAPS-2), the Hamilton rating scale for depression (HAMD-17) and the clinical global impression scale (CGI), at baseline and at weeks 1, 2 and 6. A response was defined as a > or = 30 % decrease in CAPS-2 total severity, a > or = 50 % decrease in total HAMD-17 score, and a CGI-I score < 3.
  
  
  RESULTS
  51 patients on mirtazapine (mean age/duration of illness: 59.1/33.5 years) and 49 on sertraline (mean age/duration of illness: 60.6/35.6 years) completed the study. The mean daily dosage was 34.1 mg for mirtazapine and 101.5 mg for sertraline. On the CAPS-2 total score more patients responded in the mirtazapine group at week 1 (13 vs 2 %) and week 2 (51 vs 31 %). At week 6 this difference was statistically significant (88 % vs 69 %, p = 0.039) on the CAPS-2 total score. The HAMD-17 total score and CGI-I score decreased in both groups, with no significant differences between th groups on all time points. The main side effects for the mirtazapine group were: dry mouth (19.6 %), constipation (19.6 %), somnolence (15.7 %) and weight gain (1.96 %); and for the sertraline group: indigestion (14.3 %), palpitation (6.1 %), agitation (2.0 %), epigastric soreness (2.0 %), insomnia (2.0 %) and sexual dysfunction (2.0 %).
  
  
  CONCLUSIONS
  Mirtazapine appeared to be an effective and well-tolerated treatment for PTSD in Korean veterans.
authors.affiliation: Department of Neuropsychiatry, Seoul Veterans Hospital, Seoul, Korea. vetmoon@kornet.net
authors.forename: Moon Yong
authors.initials: MY
authors.lastname: Chung
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Min
authors.forename: Yong Ju
authors.initials: YJ
authors.lastname: Jun
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Wan Chul
authors.initials: WC
authors.lastname: Kim
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Jun
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D007723:Korea; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008875:Middle Aged; D000078785:Mirtazapine; D020280:Sertraline / Q000009:adverse effects / Q000627:therapeutic use*; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy*; D014728:Veterans
chemical_list: D008803:Mianserin; D000078785:Mirtazapine; D020280:Sertraline