Intralabyrinthine fluid dynamics: Meniere disease.
OBJECTIVE
Meniere disease has long been postulated to be a disorder of intralabyrinthine fluid dynamics.


RESULTS
More recent developments in this field indicate that the control of fluid movement may be at a cellular level and that hormonal influence may be important.


CONCLUSIONS
The control of fluid and ion movements through aquaporins and gap junctions in the cell membranes are creating new perspectives in the mechanism of development of endolymphatic hydrops as well as potential methods for treatment. Intralabyrinthine fluid dynamics also play a role in the ability to locally deliver drugs to the inner ear through the middle ear.
Andrews
James C
JC
Division of Head and Neck Surgery, Sepulveda-UCLA Veterans Administration Hospital, 16111 Plummer Street, Sepulveda, CA 91343, USA. jandrews@mednet.ucla.edu
D003131:Combined Modality Therapy; D004710:Endolymph / Q000502:physiology*; D018159:Endolymphatic Hydrops / Q000503:physiopathology; D005260:Female; D006801:Humans; D007272:Injections, Intralymphatic; D007761:Labyrinthine Fluids / Q000502:physiology; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis* / Q000188:drug therapy*; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index