title: The highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans and progression of periodontal attachment loss.
abstract: The JP2 clone of Actinobacillus actinomycetemcomitans has been implicated in the etiology of periodontitis in adolescents. The aim of this two-year longitudinal study was to describe clinical attachment loss (CAL) progression and to assess its association with baseline occurrence of the JP2 and non-JP2 types of A. actinomycetemcomitans. Clinical re-examination of 121 adolescents in Morocco was performed. Progression of CAL > or = 1 mm, > or = 2 mm, > or = 3 mm, and > or = 4 mm on at least one site was found in 58%, 48%, 22%, and 6% of the subjects, respectively. Subjects who, at baseline, harbored the JP2 clone had a significantly higher progression of CAL than did subjects harboring non-JP2 types of A. actinomycetemcomitans. Subjects harboring non-JP2 types displayed a marginally higher CAL progression than did subjects who were culture-negative for A. actinomycetemcomitans.
authors.affiliation: Dental Faculty, University of Rabat, Morocco. dhaubek@odont.au.dk
authors.forename: D
authors.initials: D
authors.lastname: Haubek
authors.forename: O-K
authors.initials: OK
authors.lastname: Ennibi
authors.forename: K
authors.initials: K
authors.lastname: Poulsen
authors.forename: N
authors.initials: N
authors.lastname: Benzarti
authors.forename: V
authors.initials: V
authors.lastname: Baelum
mesh_terms: D000293:Adolescent; D016976:Aggregatibacter actinomycetemcomitans / Q000235:genetics / Q000472:pathogenicity*; D010520:Aggressive Periodontitis / Q000453:epidemiology* / Q000382:microbiology*; D001427:Bacterial Toxins; D016022:Case-Control Studies; D002999:Clone Cells; D003773:Dental Plaque / Q000382:microbiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D017720:Molecular Epidemiology; D009018:Morocco / Q000453:epidemiology; D016017:Odds Ratio; D017622:Periodontal Attachment Loss / Q000382:microbiology*; D013045:Species Specificity
chemical_list: D001427:Bacterial Toxins