title: A case of diffuse panbronchiolitis (DPB) in a patient positive for HTLV-1.
abstract: Diffuse panbronchiolitis (DPB), an important cause of progressive obstructive lung disease in the Far East, represents a distinctive sinobronchial syndrome with typical radiologic and histologic features. Human T-cell lymphotrophic virus (HTLV-1) is a retrovirus that clinically and experimentally suppresses T-cell function and immune responses. The clinical and immunologic features of DPB in HTLV-1 carriers are unclear, because DPB and HTLV-1 endemic areas around the world are mostly non-overlapping. However, both diseases are endemic in Japan. We present a patient with DPB positive for HTLV-1 whose cellular and humoral immune responses were markedly impaired. Six y after diagnosis of DPB, the patient developed respiratory failure and died in spite of treatment with clarithromycin.
authors.affiliation: Department of Internal Medicine, Nishida Hospital, Saiki City, Oita 876-0831, Japan. matsuno@med.oita-u.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsuno
authors.forename: Kanako
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hajime
authors.initials: H
authors.lastname: Kataoka
authors.forename: Eishi
authors.initials: E
authors.lastname: Miyazaki
authors.forename: Tosihide
authors.initials: T
authors.lastname: Kumamoto
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents; D001989:Bronchiolitis Obliterans / Q000150:complications / Q000175:diagnosis*; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D018450:Disease Progression; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D017809:Fatal Outcome; D015490:HTLV-I Infections / Q000150:complications / Q000175:diagnosis*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D007564:Japan; D008297:Male; D011552:Pseudomonas Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D012131:Respiratory Insufficiency / Q000175:diagnosis; D012720:Severity of Illness Index
chemical_list: D000900:Anti-Bacterial Agents