Significant ABO hemolytic disease of the newborn in a group B infant with a group A2 mother.
ABO hemolytic disease of the newborn (HDN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case in which clinically significant ABO-HDN occurred in a group B neonate from anti-B of a group A2 mother. The IgG anti-B titer was much higher (256) than that found in a group A1 mother/infant control group (</= 32). The maternal antibody screen was negative and antibodies to low-frequency antigens were not detected. Therefore, when evaluating unexplained HDN in a group B newborn of a group A mother, it may be relevant to determine the subgroup of the mother. As presented here, anti-B from a group A2 mother may, on occasion, be responsible for HDN.
Jeon
H
H
University of Chicago Hospitals, Department of Pathology, Blood Bank, IL 60637, USA.
Calhoun
B
B
Pothiawala
M
M
Herschel
M
M
Baron
B W
BW