Changes in water solubility of proteins in aging rat brain.
Changes in the water solubility of proteins in the brain tissue of Wistar rats were investigated: (i) during aging (in 3-32 month animals) and (ii) 24 h after killing 3 month animals. The protein concentration was determined by the method of Lowry. In both cases we observed a considerable difference in the protein solubility, i.e., that the ratio of water-soluble to water-insoluble proteins changed. A change of protein solubility was largest in the brain regions especially sensitive to the oxygen supply (hippocampus, striatum, hypothalamus and cortex) and is statistically significant already in 14 month animals.
Kristofiková
Z
Z
Psychiatric Research Institute, 181 03 Prague, Czechoslovakia.
Benesová
O
O
Tejkalová
H
H