title: Prediction of chemotherapeutic response in ovarian cancer with DNA microarray expression profiling.
abstract: Ovarian carcinoma is a leading cause of gynecologic cancer death in women. Despite treatment, a large number of women with ovarian cancer eventually relapse and die of the disease. Hence, recurrent ovarian cancer continues to be a therapeutic dilemma, possibly a result of the emergence of drug resistance during relapse. Recent advances in expression genomics enable global transcript analysis that leads to molecular classification of cancers and prediction of outcome and treatment response. We did a cDNA microarray examination of the expression profiles of eight primary ovarian cancers stratified into two groups based on their chemotherapeutic response. We applied a voice-speech-pattern recognition algorithm for microarray data analysis and were able to model and predict the response of these patients to chemotherapy from their expression profiles. Hence, gene expression profiling by means of DNA microarray may be applied diagnostically for predicting treatment response in ovarian cancer.
authors.affiliation: Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA.
authors.forename: Zachariah E
authors.initials: ZE
authors.lastname: Selvanayagam
authors.forename: Tak Hong
authors.initials: TH
authors.lastname: Cheung
authors.forename: Nien
authors.initials: N
authors.lastname: Wei
authors.forename: Ragini
authors.initials: R
authors.lastname: Vittal
authors.forename: Keith Wing Kit
authors.initials: KW
authors.lastname: Lo
authors.forename: Winnie
authors.initials: W
authors.lastname: Yeo
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Kita
authors.forename: Roald
authors.initials: R
authors.lastname: Ravatn
authors.forename: Tony Kwok Hung
authors.initials: TK
authors.lastname: Chung
authors.forename: Yick Fu
authors.initials: YF
authors.lastname: Wong
authors.forename: Khew-Voon
authors.initials: KV
authors.lastname: Chin
mesh_terms: D000328:Adult; D000368:Aged; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D010363:Pattern Recognition, Automated