title: Acute myeloid leukemia following treatment with cladribine for hairy cell leukemia: a case report and review of the literature.
abstract: The overall survival of patients with hairy cell leukemia (HCL) has significantly increased in recent years because of the development of effective treatments such as interferon alpha and purine analogs. Several reports have described an increased risk of secondary cancers, particularly solid tumors, in patients with HCL. We describe a case of a patient with HCL, who had prolonged pancytopenia after a single course of cladribine. Fifteen months after the diagnosis of HCL the patient developed acute myeloid leukemia (AML) and died shortly afterwards. Review of the literature shows few reports of acute leukemia in HCL patients. All of the 11 reported cases of leukemia in patients with HCL have been in patients who have been treated with either interferon alpha or purine analogs, and developed several years (mean 4.3 years; range 1.6-6.4 years) after the diagnosis of HCL. Our case is unusual in that the patient developed AML shortly (1.2 years) after the diagnosis and treatment of HCL. Further studies are needed to clarify whether leukemias seen in patients following the treatment of their HCL are incidental findings or related to HCL and its treatments.
authors.affiliation: Department of Medicine Hematology/Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, USA. hassanr@mail.nih.gov
authors.forename: R
authors.initials: R
authors.lastname: Hassan
authors.forename: M
authors.initials: M
authors.lastname: Gupta
authors.forename: W
authors.initials: W
authors.lastname: Kern
authors.forename: H
authors.initials: H
authors.lastname: Ozer
mesh_terms: D000208:Acute Disease; D000368:Aged; D017338:Cladribine / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D007951:Leukemia, Myeloid / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D016609:Neoplasms, Second Primary / Q000139:chemically induced; D010198:Pancytopenia / Q000139:chemically induced
chemical_list: D017338:Cladribine