title: 1,2,4-trioxepanes: redox-cleavable protection for carbonyl groups.
abstract: [reaction: see text] 1,2,4-trioxepanes, readily prepared and easily handled derivatives of aldehydes and ketones, are stable to a variety of synthetic conditions and yet easily deblocked with Zn/HOAc or Mg/MeOH to regenerate the parent carbonyl. Trioxepanes may provide an alternative to 1,3-dithianes for acid-stable protection of carbonyl groups.
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA.
authors.forename: Aqeel
authors.initials: A
authors.lastname: Ahmed
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Dussault