title: Comparison of spot tests with AdultaCheck 6 and Intect 7 urine test strips for detecting the presence of adulterants in urine specimens.
abstract: BACKGROUND
  Several adulterants are used to mask tests for abused drugs in urine. Adulterants such as "Klear" and "Whizzies" contain potassium nitrite while "Urine Luck" contains pyridinium chlorochromate (PCC). The presence of these adulterants cannot be detected by routine specimen integrity check (pH, specific gravity, creatinine and temperature). We previously reported the development of rapid spot tests to detect the presence of these adulterants. AdultaCheck 6 and Intect 7 urine test strips are commercially available for detecting the presence of these adulterants along with specific gravity, creatinine and pH in urine.
  
  
  METHODS
  The performance of these two test strips for detecting adulterants was compared with the results obtained by spot tests.
  
  
  RESULTS
  Both AdultaCheck 6 and Intect 7 effectively detected the presence of nitrite and pyridinium chlorochromate in urine. Moreover, both test strips successfully detected the presence of glutaraldehyde, for which no spot test is currently available. High amount of glucose and ascorbic acid did not cause any false positive result with AdultaCheck 6 or Intect 7.
  
  
  CONCLUSIONS
  Both AdultaCheck 6 and Intect 7 can be used for checking the integrity of a urine specimen submitted for drugs of abuse testing.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, 6431 Fannin, MSB 2.292, Houston, TX 77030, USA. amitava.dasgupta@uth.tmc.edu
authors.forename: Amitava
authors.initials: A
authors.lastname: Dasgupta
authors.forename: Omar
authors.initials: O
authors.lastname: Chughtai
authors.forename: Christina
authors.initials: C
authors.lastname: Hannah
authors.forename: Bonnette
authors.initials: B
authors.lastname: Davis
authors.forename: Alice
authors.initials: A
authors.lastname: Wells
mesh_terms: D001205:Ascorbic Acid / Q000652:urine; D003404:Creatinine / Q000032:analysis; D005189:False Positive Reactions; D005947:Glucose / Q000032:analysis; D005976:Glutaral / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009573:Nitrites / Q000652:urine*; D011726:Pyridinium Compounds / Q000652:urine; D011934:Reagent Strips; D012680:Sensitivity and Specificity; D013046:Specific Gravity; D015813:Substance Abuse Detection / Q000379:methods*
chemical_list: D009573:Nitrites; D011726:Pyridinium Compounds; D011934:Reagent Strips; C041349:potassium nitrite; D003404:Creatinine; C111019:pyridinium chlorochromate; D005947:Glucose; D001205:Ascorbic Acid; D005976:Glutaral