title: A case of severe chronic active Epstein-Barr virus infection with T-cell lymphoproliferative disorder.
abstract: Chronic infection with Epstein-Barr virus (EBV) without previous immunodeficiency or immuno-suppressive therapy is relatively rare. Severe chronic active EBV (SCAEBV) infection was reported for the first time in 1984 as 'chronic mononucleosis syndrome', and diagnostic criteria were proposed. It is characterized by clinical features including fever, severe hepatosplenomegaly, lymphadenopathy, hematologic features such as anemia and thrombocytopenia, and elevated antibody titers to EBV. We experienced a 21-year-old woman who initially presented with fever and chronic fatigue; however, no definite diagnosis could be made at the time of admission. Three months after the initial admission, there was evidence of only splenomegaly and the patient had persistent, multiple, paraaortic lymphadenopathies in abdominal CT. Diagnostic splenectomy was performed, and SCAEBV infection with T-cell lymphoproliferative disorder was ultimately diagnosed.
authors.affiliation: Department of Internal Medicine and Pathology, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Cho
authors.forename: In Soon
authors.initials: IS
authors.lastname: Kim
authors.forename: Hwan Cheol
authors.initials: HC
authors.lastname: Park
authors.forename: Myung Ju
authors.initials: MJ
authors.lastname: Ahn
authors.forename: Young Yiul
authors.initials: YY
authors.lastname: Lee
authors.forename: Chan Kum
authors.initials: CK
authors.lastname: Park
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012720:Severity of Illness Index; D013156:Splenectomy; D013601:T-Lymphocytes; D014057:Tomography, X-Ray Computed