title: Effect of liver transplantation on multiple bone fractures in an infant with end-stage biliary atresia: a case report.
abstract: Osteodystrophy is frequently found in children with chronic cholestatic liver disease. We herein report an end-stage case of biliary atresia that was associated with multiple bone fractures and severe growth retardation. The patient, an 8-month-old female, underwent a living-related liver transplantation and thereafter showed a dramatic improvement in growth and decrease in bone fractures. A correction of the liver function is therefore considered to be a key factor in treating osteodystrophy that is related to chronic cholestatic liver disease. It is also essential to perform liver transplantation at the most appropriate time to enhance and support the growth of these patients.
authors.affiliation: Department of Pediatric Surgery, Graduate School of Medical Sciences, 3-1-1 Maidashi, 812-8582 Higashi-ku, Fukuoka, Japan. suita@pedsurg.med.kyushu-u.ac.jp
authors.forename: Shunsaku
authors.initials: S
authors.lastname: Katsura
authors.forename: Keiko
authors.initials: K
authors.lastname: Ogita
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Taguchi
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Suita
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Yoshizumi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Soejima
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D001656:Biliary Atresia / Q000150:complications* / Q000601:surgery; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D006801:Humans; D006810:Humeral Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D007223:Infant; D016031:Liver Transplantation / Q000379:methods; D019520:Living Donors; D011171:Portoenterostomy, Hepatic; D013902:Radiography, Thoracic; D011885:Radius Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D012253:Rib Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014458:Ulna Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery