Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease.
Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (> or =130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD.
Timmermann
Lars
L
Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.
Wojtecki
Lars
L
Gross
Joachim
J
Lehrke
Ralph
R
Voges
Jürgen
J
Maarouf
Mohammed
M
Treuer
Harald
H
Sturm
Volker
V
Schnitzler
Alfons
A
D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D004292:Dominance, Cerebral / Q000502:physiology; D004359:Drug Therapy, Combination; D004553:Electric Conductivity; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009415:Nerve Net / Q000503:physiopathology; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D025321:Surgery, Computer-Assisted; D017211:Treatment Failure; D014202:Tremor / Q000503:physiopathology / Q000628:therapy
D000978:Antiparkinson Agents; D007980:Levodopa