title: A new method to destruct targeted cells using magnetizable beads and pulsed magnetic force.
abstract: We investigated a new method to destruct targeted cells using magnetizable beads and pulsed magnetic force. The cells were combined with the beads by an antigen-antibody reaction (cell/bead/antibody complex), aggregated by a magnet, and stimulated by a magnetic stimulator. The viability of the aggregated and stimulated cell/bead/antibody complexes was significantly decreased, and the cells were destructed by the penetration of the beads into the cells or rupturing of the cells by the beads. These results suggest that magnetic aggregation and pulsed magnetic stimulation can effectively damage only the cells targeted by an antigen-antibody reaction.
authors.affiliation: Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan. ogiue@medes.m.u-tokyo.ac.jp
authors.forename: Mari
authors.initials: M
authors.lastname: Ogiue-Ikeda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sato
authors.forename: Shoogo
authors.initials: S
authors.lastname: Ueno
mesh_terms: D045744:Cell Line, Tumor / Q000473:pathology / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005290:Ferric Compounds; D006801:Humans; D018189:Immunomagnetic Separation / Q000379:methods*; D007951:Leukemia, Myeloid / Q000473:pathology*; D008280:Magnetics / Q000627:therapeutic use*; D008863:Microspheres; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods; D013314:Stress, Mechanical; D016896:Treatment Outcome
chemical_list: D005290:Ferric Compounds