title: Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders.
abstract: Most inflammatory disorders are becoming more prevalent, especially in Western countries. The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) plays a prominent role in many of these inflammatory disorders. We have previously shown that SPRET/Ei mice exhibit an extreme and dominant resistance to high doses of TNF. In this report, we investigate the response of heterozygous (C57BL/6xSPRET/Ei)F1 mice in different models of inflammatory diseases. Compared with C57BL/6 mice, (B x S)F1 mice are protected against TNF-induced arthritis and are partially protected against allergic asthma in an ovalbumin-induced model. However, these mice display complete susceptibility to TNF-induced inflammatory bowel disease. These results indicate that the SPRET/Ei genome harbors potent dominant antiinflammatory genes that might be relevant for the treatment of certain chronic inflammatory diseases. It is very well possible that different genes are implicated in the different models.
authors.affiliation: Unit for Molecular Genetics in the Mouse, Department of Molecular Biomedical Research, Ghent University-Flanders Interuniversity Institute for Biotechnology, Zwijnaarde, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Staelens
authors.forename: Leen
authors.initials: L
authors.lastname: Puimège
authors.forename: Tina
authors.initials: T
authors.lastname: Mahieu
authors.forename: Gwenda
authors.initials: G
authors.lastname: Pynaert
authors.forename: Tino
authors.initials: T
authors.lastname: Hochepied
authors.forename: Annelies
authors.initials: A
authors.lastname: Vandenabeele
authors.forename: Johan
authors.initials: J
authors.lastname: Grooten
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kontoyiannis
authors.forename: Frans
authors.initials: F
authors.lastname: Van Roy
authors.forename: George
authors.initials: G
authors.lastname: Kollias
authors.forename: Claude
authors.initials: C
authors.lastname: Libert
mesh_terms: D000818:Animals; D001168:Arthritis / Q000235:genetics; D001249:Asthma / Q000235:genetics; D001992:Bronchoalveolar Lavage Fluid; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D005260:Female; D020022:Genetic Predisposition to Disease; D016678:Genome; D006579:Heterozygote; D007249:Inflammation / Q000235:genetics*; D015212:Inflammatory Bowel Diseases / Q000235:genetics; D007596:Joints / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D010047:Ovalbumin