title: Food restriction in female Wistar rats. II. Beta-adrenoceptor density in the cerebellum and in the splenic lymphocytes.
abstract: The effect of diet restriction, applied on an every-other-day schedule from 3.5 months of age on, has been investigated on the beta-adrenoceptor density in the cerebellum and in the splenic lymphocytes of old female Wistar rats. Comparing animals 6 months and 24 months old fed ad libitum, a 75% age-dependent reduction in specific binding of the agonist dihydroalprenolol was observed in cerebellar membrane preparations, while the beta-adrenoceptor density of lymphocytes remained unaltered. Diet restriction induced a partial recovery of the age-related decrease of this parameter in the cerebellum without affecting the receptor density of lymphocytes. Present results suggest that undernutrition delays the appearance of those alterations related to aging.
authors.affiliation: Cytology Center, Gerontological Research Department, I.N.R.C.A., Via Birarelli 8, 60121 Ancona, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pieri
authors.forename: F
authors.initials: F
authors.lastname: Moroni
authors.forename: F
authors.initials: F
authors.lastname: Marcheselli
authors.forename: M
authors.initials: M
authors.lastname: Falasca
authors.forename: R
authors.initials: R
authors.lastname: Recchioni