title: Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province.
abstract: OBJECTIVE
  To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection.
  
  
  METHODS
  One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP.
  
  
  RESULTS
  The frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects.
  
  
  CONCLUSIONS
  HLA-B*46 may be associated with its susceptibility to HIV-1 infections.
authors.affiliation: National Centerfor STD/AIDS Control and Prevention, Beijing 100050, China.
authors.forename: Ming-Yan
authors.initials: MY
authors.lastname: Xu
authors.forename: Kun-Xue
authors.initials: KX
authors.lastname: Hong
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Deng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Peng
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Ruan
authors.forename: Guan-Ming
authors.initials: GM
authors.lastname: Qin
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Xiao-Hu
authors.initials: XH
authors.lastname: Xu
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shao
mesh_terms: D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D004247:DNA / Q000032:analysis; D005006:Ethnicity; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000235:genetics*; D006679:HIV Seropositivity / Q000097:blood; D015497:HIV-1 / Q000472:pathogenicity*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D011795:Surveys and Questionnaires
chemical_list: D015235:HLA-B Antigens; D004247:DNA