title: Routine sirolimus eluting stent implantation for unselected in-stent restenosis: insights from the rapamycin eluting stent evaluated at Rotterdam Cardiology Hospital (RESEARCH) registry.
abstract: OBJECTIVE
  To assess the effectiveness of routine sirolimus eluting stent (SES) implantation for unselected patients with in-stent restenosis and to provide preliminary information about the angiographic outcome for lesion subgroups and for different in-stent restenosis patterns.
  
  
  METHODS
  Prospective, single centre registry.
  
  
  METHODS
  Tertiary referral centre.
  
  
  METHODS
  44 consecutive patients (53 lesions) without previous brachytherapy who were treated with SES for in-stent restenosis were evaluated. Routine angiographic follow up was obtained at six months and the incidence of major adverse cardiovascular events was evaluated.
  
  
  RESULTS
  At baseline, 42% of the lesions were focal, 21% diffuse, 26% proliferative, and 11% total occlusions. Small vessel size (reference diameter < or = 2.5 mm) was present in 49%, long lesions (> 20 mm) in 30%, treatment of bypass grafts in 13%, and bifurcation stenting in 18%. At follow up, post-SES restenosis was observed in 14.6%. No restenosis was observed in focal lesions. For more complex lesions, restenosis rates ranged from 20-25%. At the one year follow up, the incidence of death was 0, myocardial infarction 4.7% (n = 2), and target lesion revascularisation 16.3% (n = 7). The target lesion was revascularised because of restenosis in 11.6% (n = 5).
  
  
  CONCLUSIONS
  Routine SES implantation is highly effective for focal in-stent restenosis and appears to be a promising strategy for more complex patterns of restenosis.
authors.affiliation: Department of Invasive Cardiology, Thoraxcentre, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Saia
authors.forename: P A
authors.initials: PA
authors.lastname: Lemos
authors.forename: C A
authors.initials: CA
authors.lastname: Arampatzis
authors.forename: A
authors.initials: A
authors.lastname: Hoye
authors.forename: M
authors.initials: M
authors.lastname: Degertekin
authors.forename: K
authors.initials: K
authors.lastname: Tanabe
authors.forename: G
authors.initials: G
authors.lastname: Sianos
authors.forename: P C
authors.initials: PC
authors.lastname: Smits
authors.forename: W J
authors.initials: WJ
authors.lastname: van der Giessen
authors.forename: P J
authors.initials: PJ
authors.lastname: de Feyter
authors.forename: R T
authors.initials: RT
authors.lastname: van Domburg
authors.forename: P W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020123:Sirolimus / Q000627:therapeutic use*; D015607:Stents
chemical_list: D004343:Drug Implants; D007166:Immunosuppressive Agents; D020123:Sirolimus