title: Increased risk of symptomatic gallbladder disease in adults with Down syndrome.
abstract: Previous reports have documented an increased prevalence of asymptomatic cholelithiasis among children with Down syndrome. Whether this predisposes adults with Down syndrome to symptomatic gallbladder disease has not been studied. A case control study compared the rate of symptomatic gallbladder disease in 28 index cases of adults with Down syndrome and that of sex-matched controls. The rate of gallbladder disease was 25% among the Down syndrome group, compared to 4.5% among the control group (P = 0.002). Patients with Down syndrome were also more likely to have a family medical history of gallbladder disease. Utilizing logistic regression analysis, the adjusted relative risk for gallbladder disease among individuals with Down syndrome was 3.52.
authors.affiliation: Fairview/Cleveland Clinic Family Practice Residency, 18200 Lorain Avenue, Cleveland, OH 44111, USA.
authors.forename: Carl V
authors.initials: CV
authors.lastname: Tyler
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Zyzanski
authors.forename: Lloyd
authors.initials: L
authors.lastname: Runser
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002769:Cholelithiasis / Q000209:etiology* / Q000235:genetics*; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors