Effects of green tea polyphenol on cognitive and acetylcholinesterase activities.
The effect of tea polyphenol (TP) on cognitive and anti-cholinesterase activity was examined in scopolamine-treated mice. Chronic administration of TP significantly reversed scopolamine-induced retention deficits in both step-through passive avoidance and spontaneous alternation behavior tasks. Furthermore, TP exhibited a dramatic inhibitory effect on acetylcholinesterase activity. This finding suggests that TP might be useful in the treatment of Alzheimer's disease.
Kim
Hye Kyung
HK
Department of Food and Biotechnology, Hanseo University, Seosan, Korea. hkkim111@hanseo.ac.kr
Kim
Mija
M
Kim
Sunki
S
Kim
Mujo
M
Chung
Joo Ho
JH
D000110:Acetylcholinesterase / Q000187:drug effects*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D008569:Memory Disorders / Q000188:drug therapy; D051379:Mice; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D059808:Polyphenols; D012601:Scopolamine; D013662:Tea / Q000737:chemistry*
D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D012601:Scopolamine; D000110:Acetylcholinesterase