title: Phyllodes tumor of the prostate: recurrent obstructive symptom and stromal proliferative activity.
abstract: We report the case of a 59-year-old man with a metachronous development of phyllodes tumor and adenocarcinoma of the prostate. He complained of urinary obstruction and transurethral resections of the prostate (TUR-P) had been performed six times in 10 years. Microscopic examination showed cystically dilated glands consisting of bizarre cells with pleomorphic, hyperchromatic nuclei in the stroma at the sixth TUR-P. Radical prostatectomy was performed against recurrences and adenocarcinoma was incidentally detected. Apparent up-regulation of proliferative nuclear antigens (PCNA), but not p53, was observed in the prostatectomy specimen by Western blotting. Active proliferation of stromal cells is considered to have caused the recurrent obstructive symptom.
authors.affiliation: Department of Urology, Saiseikai Shimonoseki General Hospital, 3-4-1 Kifune-cho, Shimonoseki, Yamaguchi 751-8502, Japan. k-siraisi@simo.saiseikai.or.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Shiraishi
authors.forename: Jun
authors.initials: J
authors.lastname: Mohri
authors.forename: Satoshi
authors.initials: S
authors.lastname: Eguchi
authors.forename: Yoriaki
authors.initials: Y
authors.lastname: Kamiryo
authors.forename: Hayato
authors.initials: H
authors.lastname: Sanefuji
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D003251:Constriction, Pathologic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology* / Q000601:surgery; D003557:Phyllodes Tumor / Q000150:complications / Q000473:pathology* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D017154:Stromal Cells / Q000473:pathology*; D014570:Urologic Diseases / Q000209:etiology*