Interstitial pneumonitis related to flutamide monotherapy for prostate cancer.
A 88-year-old man with prostate cancer was receiving non-steroidal anti-androgen therapy (flutamide, 375 mg/day). Three weeks after starting therapy, the patient developed dyspnea and bilateral pulmonary interstitial infiltrates. The withdrawal of flutamide and the initiation of steroid therapy resulted in clinical improvement.
Nomura
Masayoshi
M
Department of Urology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu-city 807-8555, Japan. nomusan@med.uoeh-u.ac.jp
Sato
Hideki
H
Fujimoto
Naohiro
N
Matsumoto
Tetsuro
T
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D005485:Flutamide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D013902:Radiography, Thoracic; D019233:Retreatment; D014057:Tomography, X-Ray Computed
D018931:Antineoplastic Agents, Hormonal; D005485:Flutamide; D011239:Prednisolone