title: A semiclosed-loop optimal control system for blood glucose level in diabetics.
abstract: In this manuscript, the well-known Bergman nonlinear mathematical model of the plasma glucose/insulin interaction is adopted and a semi closed-loop optimal technique is proposed for the correction of hyperglycemia in diabetic subjects. Computer simulations are used to evaluate the effectiveness of the proposed technique and to demonstrate its superiority in controlling hyperglycemia over other existing algorithms.
authors.affiliation: Department of Electrical Engineering, Jordan University of Science and Technology, Irbid. mohib@just.edu.jo
authors.forename: M S
authors.initials: MS
authors.lastname: Ibbini
authors.forename: M A
authors.initials: MA
authors.lastname: Masadeh
authors.forename: M M Bani
authors.initials: MM
authors.lastname: Amer
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis*; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage*; D008954:Models, Biological; D017711:Nonlinear Dynamics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007328:Insulin