title: Diterpenoids from Isodon melissoides.
abstract: Nine new diterpenoids, melissoidesins M-U (1-9), along with five known analogues, melissoidesin F (10), xindongnin B (11), melissoidesin G (12), melissoidesin E (13), and dawoensin A (14), were isolated from the aerial parts of Isodon melissoides. The structures of new compounds were elucidated by analysis of spectral evidence including extensive 2D NMR data. Compounds 2, 3, 7, 11, 12, and 14 showed cytotoxicity against the human tumor BGC-823 cell line with IC(50) values less than 10 microg/mL, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Zhao
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Chen
authors.initials: C
authors.lastname: Qing
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Fu-Sheng
authors.initials: FS
authors.lastname: Wang
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D037602:Isodon / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes