title: Human papillomavirus-32-positive extragenital Bowenoid papulosis (BP) in a HIV patient with typical genital BP localization.
abstract: OBJECTIVE
  Bowenoid papulosis (BP) is characterized by multiple maculopapular lesions of the genitalia; extragenital localization is rarely found. Human papillomavirus (HPV) type 16 has been found in most cases of BP, but the other HPV genotypes associated with BP had been poorly characterized.
  
  
  OBJECTIVE
  We describe an extragenital BP with concomitant genital involvement in an HIV-positive woman.
  
  
  METHODS
  Several HPV gene-specific amplifications and sequencing were performed on DNA extracted from biopsy samples.
  
  
  RESULTS
  The presence of HPV-16 DNA in anogenital and HPV-32 DNA in lip lesions was demonstrated in the absence of any other HPV type and with no coinfection. Semiquantitative polymerase chain reaction analysis revealed that HPV-16 and -32 DNA sequences are in the episomal state.
  
  
  CONCLUSIONS
  This is the first report of BP associated with HPV-32 (the causative agent of a benign hyperplasia) and a rare case of BP associated with 2 HPV types in the same patient. The immune depression could have modified the normal benign progression of the extragenital lesions.
authors.affiliation: Dipartimento di Medicina Sperimentale e Patologia, Sezione di Virologia, Viale di Porta Tiburtina, n. 28, 00185- Rome, Italy. annamarta.degener@uniroma1.it
authors.forename: Anna Marta
authors.initials: AM
authors.lastname: Degener
authors.forename: Luigi
authors.initials: L
authors.lastname: Laino
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pierangeli
authors.forename: Gianluca
authors.initials: G
authors.lastname: Accappaticcio
authors.forename: Daniele
authors.initials: D
authors.lastname: Innocenzi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pala
mesh_terms: D000328:Adult; D001003:Anal Canal; D001913:Bowen's Disease / Q000175:diagnosis* / Q000821:virology; D017931:DNA Primers; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections; D006801:Humans; D008046:Lip; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology; D016133:Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000821:virology; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000821:virology; D014844:Vulva
chemical_list: D017931:DNA Primers; D004279:DNA, Viral