Ardisinones A-E, novel diarylundecanones from Ardisia arborescens.
A phytochemical study on an ethanol extract of Ardisia arborescens resulted in the isolation of five new diarylundecanones, named ardisinones A-E (1-5). The structures were established by HRESIMS and NMR ((1)H, (13)C, DEPT, HSQC, HMBC) as 11-(2-acetoxy-6-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)undecan-1-one (1), 11-(2-acetoxy-6-hydroxyphenyl)-1-(2,6-dihydroxy-4-methoxyphenyl)undecan-1-one (2), 1-(2,6-dihydroxy-4-methoxyphenyl)-11-(2,6-dihydroxyphenyl)undecan-1-one (3), 1-(2,4,6-trihydroxyphenyl)-11-(2,6-dihydroxyphenyl)undecan-1-one (4), and 1-(2,4,6-trihydroxyphenyl)-11-(2-hydroxyphenyl)undecan-1-one (5). In our in vitro disk diffusion assay, compounds 1 and 4 showed some slight inhibition of three bacteria, while 2 and 3 did not show antimicrobial activity.
Zheng
Ying
Y
Chengdu Institute of Biology and Chengdu Institute of Organic Chemistry, Granduate School of the Chinese Academy of Sciences, P.O. Box 416, Chengdu 610041, Sichuan, People's Republic of China.
Deng
Yun
Y
Wu
Feng-E
FE
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031644:Ardisia / Q000737:chemistry*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D007659:Ketones; D010636:Phenols