The effect of oral administration of calcium and magnesium on intestinal oxalate absorption in humans.
Calcium oxalate (CaOx) urolithiasis is the most common urinary stone disease (70-75 % of all stones consist of CaOx in countries with western diet). Oxalate is the most lithogenic substance in CaOx crystallisation in urine. Oxalate is either synthesized within the body or absorbed from food. As oxalate is not metabolized in the human body, it appears unchanged in urine. Conventional analysis methods cannot distinguish between endogenous and exogenous oxalate. Our [13C2]oxalate absorption test enabled measurement of intestinal oxalate absorption and quantification of the influence of Ca- and Mg-supplementation on it. The effects of the oral administration of these supplements were compared in order to obtain valid data for recommendations for CaOx urolithiasis patients. A 10 mmol supplement of both ions decreased the oxalate absorption significantly, calcium being more than twice as effective.
Voss
Susanne
S
Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Germany. s.voss@uni-bonn.de
Zimmermann
Diana J
DJ
Hesse
Albrecht
A
von Unruh
Gerd E
GE
D000284:Administration, Oral; D000328:Adult; D002118:Calcium / Q000494:pharmacology* / Q000652:urine; D002250:Carbon Radioisotopes / Q000032:analysis / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008274:Magnesium / Q000494:pharmacology* / Q000652:urine; D008297:Male; D010070:Oxalates / Q000378:metabolism* / Q000652:urine
D002250:Carbon Radioisotopes; D010070:Oxalates; D008274:Magnesium; D002118:Calcium