title: Bronchial artery revascularization restores peribronchial tissue oxygenation after lung transplantation.
abstract: With the interruption of the bronchial arteries after lung transplantation, nutritive support is dependent on collateral flow by the pulmonary arteries with desaturated venous blood. Consequently, oxygen deficiency of the peribronchial and dependent lung tissue may occur. Using a canine model for left lung transplantation, we investigated hypoxic peribronchial tissue after conventional lung transplantation and demonstrated restitution of tissue oxygenation after transplantation with bronchial artery revascularization (BAR) (BAR group: Po2 120.4 +/- 28.7 mm Hg; control group Po2 6.8 +/- 2.8; p < 0.001). BAR in lung transplantation protects peribronchial tissue of the transplanted graft from hypoxia in the early phase after reperfusion.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Essen, Essen, Germany. markus.kamler@uni-essen.de
authors.forename: Markus
authors.initials: M
authors.lastname: Kamler
authors.forename: Kai
authors.initials: K
authors.lastname: Nowak
authors.forename: Matthias
authors.initials: M
authors.lastname: Bock
authors.forename: Ulf
authors.initials: U
authors.lastname: Herold
authors.forename: Johann
authors.initials: J
authors.lastname: Motsch
authors.forename: Siegfried
authors.initials: S
authors.lastname: Hagl
authors.forename: Martha Maria
authors.initials: MM
authors.lastname: Gebhard
authors.forename: Heinz
authors.initials: H
authors.lastname: Jakob
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D001784:Blood Gas Analysis; D001980:Bronchi / Q000378:metabolism*; D001981:Bronchial Arteries / Q000601:surgery*; D002302:Cardiac Output / Q000502:physiology; D004285:Dogs; D016040:Lung Transplantation / Q000379:methods*; D023421:Models, Animal; D010865:Pilot Projects; D011652:Pulmonary Circulation / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D015424:Reperfusion; D013552:Swine