Combining DNA damaging agents and checkpoint 1 inhibitors.
During the cell cycle that leads to mitosis, checkpoints are activated in response to DNA damage. The checkpoints control the ability of cells to arrest the cell cycle allowing time to repair the DNA. In more than 50% of cancer cells, the G1 checkpoint is inactive due to mutations of p53. Therefore, the combination of a DNA damaging agent with a G2 checkpoint inhibitor should force selectively cancer cells into a premature and lethal mitosis. This approach which has recently drawn considerable interest is discussed in this paper.
Prudhomme
Michelle
M
Université Blaise Pascal, Laboratoire Synthèse et Etude de Systèmes à Intérêt Biologique, UMR 6504 du CNRS, 63177 Aubière, France. mprud@chimie.univ-bpclermont.fr
D000970:Antineoplastic Agents / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry; D004249:DNA Damage; D016193:G1 Phase; D016195:G2 Phase; D016158:Genes, p53; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008938:Mitosis; D008954:Models, Biological; D008956:Models, Chemical; D009154:Mutation
D000970:Antineoplastic Agents; D004247:DNA; D006918:Hydroxyurea