title: A bridge from short-term to long-term left ventricular assist device--experimental verification of a physiological controller.
abstract: A physiological controller is a key component to optimize the performance of left ventricular assist devices (LVADs) from short term to long term (10-20 years). The difficulties of its design lie in the inaccurate modeling of any particular human cardiovascular system because of limited knowledge, the large fluctuation of systemic parameters in normal daily life, nonlinearity introduced by one-way heart valves, and restriction on available sensors. The desired physiological controller for a permanent LVAD is expected to handle different activity levels such as sleeping, resting and exercising, and different pathological levels of left ventricular failure. In this study, a physiological controller designed for a long-term continuous flow (CF) LVAD was tested in a mock circulatory loop. The pressure head across the LVAD and motor signals were used as feedback signals, which were obtained from long-term reliable sensors. Three activities and five different pathological levels of left ventricular failure were simulated to test the performance of the designed controller. The experimental results showed that the designed controller restored the total peripheral flow and arterial pressure, and decreased the left ventricular end-diastolic pressure to a safe range. The suction of the left ventricle was successfully reversed by the designed controller. The controller thus was proven to be able to control the LVAD properly in many of the possible physiological conditions experienced by LVAD recipients in long term.
authors.affiliation: Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA, USA. yxw22@psu.edu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.forename: Paul E
authors.initials: PE
authors.lastname: Allaire
authors.forename: Gang
authors.initials: G
authors.lastname: Tao
authors.forename: Milton
authors.initials: M
authors.lastname: Adams
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Liu
authors.forename: Houston
authors.initials: H
authors.lastname: Wood
authors.forename: Don B
authors.initials: DB
authors.lastname: Olsen
mesh_terms: D001698:Biomedical Engineering; D001783:Blood Flow Velocity; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D013997:Time Factors