[Effect of total glucosides of Centella asiatica on antagonizing liver fibrosis induced by dimethylnitrosamine in rats].
OBJECTIVE
To investigate the anti-liver fibrosis effect of total glucosides of Centella asiatica (GCA) in experimental rats.


METHODS
Rat liver fibrosis model was induced by injecting dimethylnitrosamine (DMN) intraperitoneally for 6 weeks. Rats were randomly divided into 6 groups, the normal group, the model group, the positive control group treated by colchicine, and the three GCA groups treated by high, moderate and low dosage of GCA through gastrogavage started simultaneously with the modeling. At the end of the experiment, levels of serum total protein (TP), albumin (ALB), alanine transaminase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) were measured, and the pathology of liver tissue was observed.


RESULTS
The liver function in the GCA groups was improved, the levels of serum ALT, AST, HA were significantly lower than those in the model group (P < 0.05). Histopathological observation showed that GCA has significant anti-liver fibrosis effect.


CONCLUSIONS
GCA has significant preventive and therapeutic effect on DMN induced liver fibrosis in rats.
Ming
Zhi-jun
ZJ
Department of Pharmacy, School of Medicine, Suzhou University, Jiangsu (215007). mingzj4451@sina.com
Liu
Shi-zeng
SZ
Cao
Li
L
D000818:Animals; D028041:Centella / Q000737:chemistry*; D004128:Dimethylnitrosamine; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D008111:Liver Function Tests; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D005960:Glucosides; D004128:Dimethylnitrosamine