title: New decalin derivatives, eujavanoic acids A and B, from Eupenicillium javanicum.
abstract: Two new decalin derivatives, eujavanoic acids A (1) and B (2), were isolated from Eupenicillium javanicum, along with several compactin derivatives. The structures of 1 and 2 were determined by spectroscopic methods and modified Mosher's method. The side chain (2-methylbutanoyloxy) and acid functionalities of compactin derivatives were necessary to show the antifungal activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Okamoto
authors.forename: Tomoo
authors.initials: T
authors.lastname: Hosoe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Itabashi
authors.forename: Koohei
authors.initials: K
authors.lastname: Nozawa
authors.forename: Kaoru
authors.initials: K
authors.lastname: Okada
authors.forename: Galba Maria de Campos
authors.initials: GM
authors.lastname: Takaki
authors.forename: Minoru
authors.initials: M
authors.lastname: Chikamori
authors.forename: Takashi
authors.initials: T
authors.lastname: Yaguchi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Fukushima
authors.forename: Makoto
authors.initials: M
authors.lastname: Miyaji
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kawai
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; C493124:eujavanoic acid A; C493123:eujavanoic acid B; C012258:mevastatin; C007229:decalin; D008148:Lovastatin