A new scaffold for the stereoselective synthesis of alpha-O-linked glycopeptide mimetics.
alpha-O-Linked glycohomoglutamates are obtained as diastereomerically pure compounds by chemo-, regio-, and stereoselective cycloadditions between glycals and aspartic acid derivatives. The latter constitute orthogonally functionalized scaffolds for glycopeptide mimetics.
Venturi
Francesca
F
Dipartimento di Chimica Organica Ugo Schiff, Università di Firenze, via della Lastruccia, 13 I-50019 Sesto Fiorentino (FI), Italy.
Venturi
Chiara
C
Liguori
Francesca
F
Cacciarini
Martina
M
Montalbano
Monica
M
Nativi
Cristina
C
D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D018716:Molecular Mimicry; D015394:Molecular Structure; D013237:Stereoisomerism
D006020:Glycopeptides