title: Microarray image enhancement by denoising using stationary wavelet transform.
abstract: Microarray imaging is considered an important tool for large scale analysis of gene expression. The accuracy of the gene expression depends on the experiment itself and further image processing. It's well known that the noises introduced during the experiment will greatly affect the accuracy of the gene expression. How to eliminate the effect of the noise constitutes a challenging problem in microarray analysis. Traditionally, statistical methods are used to estimate the noises while the microarray images are being processed. In this paper, we present a new approach to deal with the noise inherent in the microarray image processing procedure. That is, to denoise the image noises before further image processing using stationary wavelet transform (SWT). The time invariant characteristic of SWT is particularly useful in image denoising. The testing result on sample microarray images has shown an enhanced image quality. The results also show that it has a superior performance than conventional discrete wavelet transform and widely used adaptive Wiener filter in this procedure.
authors.affiliation: Mobile Information and Network Technologies Centre, School of Computing and Information Systems, Kingston University, London, Kingston Upon Thames KT1 2EE, UK. xin-heng.wang@kingston.ac.uk
authors.forename: X H
authors.initials: XH
authors.lastname: Wang
authors.forename: Robert S H
authors.initials: RS
authors.lastname: Istepanian
authors.forename: Yong Hua
authors.initials: YH
authors.lastname: Song
mesh_terms: D000465:Algorithms; D004247:DNA / Q000032:analysis* / Q000737:chemistry / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D036103:Nanotechnology / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010363:Pattern Recognition, Automated; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA / Q000379:methods; D012815:Signal Processing, Computer-Assisted; D013269:Stochastic Processes
chemical_list: D004247:DNA