title: Groin tissue necrosis requiring skin graft following parenteral abuse of buprenorphine tablets.
abstract: In May 2002 Buprenorphine (Subutex) was listed on the Australian Pharmaceutical Benefits Schedule for treatment in opioid dependence. In addition to broadening treatment options, buprenorphine has the advantage of an improved safety profile. The risk of overdose is lessened but other risks remain due to diversion. French experience reports widespread deviation of buprenorphine sublingual tablets to intravenous injection. We report a case of attempted parenteral administration of buprenorphine tablets. Stringent protocols for dispensing are appropriate.
authors.affiliation: Alcohol and Drug Assessment Unit, Princess Alexandra Hospital, Brisbane, Queensland, Australia. GeraldFeeney@health.qld.gov.au
authors.forename: G F X
authors.initials: GF
authors.lastname: Feeney
authors.forename: P
authors.initials: P
authors.lastname: Fairweather
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D002047:Buprenorphine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006119:Groin / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D009336:Necrosis / Q000139:chemically induced*; D016038:Skin Transplantation / Q000379:methods*; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine