title: Catalytic efficiency of a new tridentate ferrocenyl phosphine auxiliary: Sonogashira cross-coupling reactions of alkynes with aryl bromides and chlorides at low catalyst loadings of 10(-1) to 10(-4) mol %.
abstract: [structure: see text] The catalytic activity in Sonogashira cross-coupling reactions of alkynes with a variety of aryl halides (including chlorides) using a multidentate ferrocenyl phosphine is presented. The novel mixed ferrocenyl aryl/alkyl triphosphine is thermally stable and insensitive to air or moisture, and its robustness allows aryl alkynylation at 10(-1) to 10(-4) mol % catalyst loadings with TONs up to 250,000. Copper-free coupling using phenylacetylene is also accessible in good yield.
authors.affiliation: Laboratoire de Synthèse et d'Electrosynthèse Organométalliques UMR-CNRS 5188, Université de Bourgogne, 9 Avenue Alain Savary, 21078 Dijon, France. jean-cyrille.hierso@u-bourgogne.fr
authors.forename: Jean-Cyrille
authors.initials: JC
authors.lastname: Hierso
authors.forename: Aziz
authors.initials: A
authors.lastname: Fihri
authors.forename: Régine
authors.initials: R
authors.lastname: Amardeil
authors.forename: Philippe
authors.initials: P
authors.lastname: Meunier
authors.forename: Henri
authors.initials: H
authors.lastname: Doucet
authors.forename: Maurice
authors.initials: M
authors.lastname: Santelli
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Ivanov