title: Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation.
abstract: Partial nerve injury results in chronic pain that is difficult to treat effectively. To investigate the anatomic basis of this phenomenon we used wheat germ agglutinin-horseradish peroxidase (WGA-HRP) to label the central projections of uninjured small fibers (Adelta and C) in a well-established model of neuropathic pain created by selective spinal nerve ligation in the adult. We found extensive sprouting of uninjured WGA-HRP-labeled afferents into the central termination field in lamina II of dorsal horn normally occupied by L5 afferents whose peripheral axons had been ligated distal to the dorsal root ganglion. The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain.
authors.affiliation: Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Hu
authors.forename: Marina
authors.initials: M
authors.lastname: Mata
authors.forename: Shuanglin
authors.initials: S
authors.lastname: Hao
authors.forename: Gui
authors.initials: G
authors.lastname: Zhang
authors.forename: David J
authors.initials: DJ
authors.lastname: Fink
mesh_terms: D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D001370:Axonal Transport; D006930:Hyperalgesia / Q000503:physiopathology; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000503:physiopathology*; D013119:Spinal Cord Injuries / Q000503:physiopathology*