title: The effect of seated exercise on fatigue and quality of life in women with advanced breast cancer.
abstract: OBJECTIVE
  To examine the effects of a seated exercise program on fatigue and quality of life (QOL) in women with metastatic breast cancer.
  
  
  METHODS
  Randomized, controlled, longitudinal trial.
  
  
  METHODS
  Outpatient clinic of a comprehensive cancer center.
  
  
  METHODS
  Convenience sample of 38 women who were beginning outpatient chemotherapy.
  
  
  METHODS
  Subjects were randomized to a control or intervention group; the intervention was performance of a seated exercise program using home videotape three times per week for four cycles of chemotherapy. All subjects completed the Functional Assessment of Chronic Illness Therapy Fatigue Version IV (FACIT F) at baseline and at the time of the next three cycles. Subjects were asked to document the frequency, duration, and intensity of all exercise participation on monthly calendars.
  
  
  METHODS
  Exercise, fatigue, and QOL.
  
  
  RESULTS
  32 subjects, 16 per group, completed the study follow-up. With a mixed modeling approach, total FACIT F scores for the entire sample declined at a significant rate (p = 0.003) beginning with cycle 3 but at a slower rate for the experimental group (p = 0.02). Fatigue scores indicated less increase and physical well-being subscale scores showed less decline for the experimental group (p = 0.008 and p = 0.02, respectively).
  
  
  CONCLUSIONS
  Women with advanced breast cancer randomized to the seated exercise intervention had a slower decline in total and physical well-being and less increase in fatigue scores starting with the third cycle of chemotherapy.
  
  
  CONCLUSIONS
  Seated exercise may be a feasible exercise program for women with advanced cancer for controlling fatigue and improving physical well-being.
authors.affiliation: University of Texas Health Science Center, Houston, TX, USA. judy@jheadley.com
authors.forename: Judith A
authors.initials: JA
authors.lastname: Headley
authors.forename: Kristin K
authors.initials: KK
authors.lastname: Ownby
authors.forename: Lauri D
authors.initials: LD
authors.lastname: John
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000451:nursing / Q000523:psychology; D005081:Exercise Therapy / Q000193:education; D005221:Fatigue / Q000209:etiology / Q000451:nursing / Q000523:psychology / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D010045:Outpatients; D010342:Patient Acceptance of Health Care; D010349:Patient Compliance; D010353:Patient Education as Topic; D011187:Posture; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014743:Videotape Recording