Alternative quality control for technetium-99m IDA complexes.
A quality control procedure for 99mTc-IDA complexes based on the use of C18 Sep-pak cartridges is developed and the validation of the procedure presented. C18 Sep-pak cartridges are pretreated by washing with 95% ethanol followed by 10(-3) N hydrochloric acid. A small amount of the 99mTc-IDA complex is applied, washed with 10(-3) N hydrochloric acid and eluted with 95% ethanol. The radiochemical purity values obtained for 99mTc-mebrofenin and 99mTc-disofenin using this Sep-pak procedure are comparable to those obtained using the standard two strip (ITLC-SG/100% methanol, ITLC-SA/20% saline) procedure.
Billinghurst
Mervyn W
MW
Radiopharmacy, Health Sciences Centre, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9. mbillinghurst@hsc.mb.ca
Eckert
Kellie
K
Mang'era
Kennedy
K
D002855:Chromatography, Thin Layer / Q000379:methods*; D007098:Imino Acids / Q000032:analysis* / Q000737:chemistry*; D015609:Organotechnetium Compounds / Q000032:analysis* / Q000737:chemistry*; D011785:Quality Assurance, Health Care / Q000379:methods*; D019275:Radiopharmaceuticals / Q000032:analysis / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
D007098:Imino Acids; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C046767:technetium Tc 99m iminodiacetic acid; D012822:Silicon Dioxide; C042953:octadecyl silane-bonded silica