title: [Effect of Yiqi Huayu recipe on peanut agglutinin-binding molecules and Schwann's cells in rats after lumbar nerve root compression].
abstract: OBJECTIVE
  To study the effect of Yiqi Huayu Recipe on peanut agglutinin-binding molecules (PNA-BMs) and Schwann's cells (Sc) of the neuromuscular junction after L5 nerve root compression in rats.
  
  
  METHODS
  The rats were given Yiqi Huayu Recipe at the 10th, 20th, 30th and 60th day after L5 nerve root compression. Using immunohistochemistry and confocal laser scanning techniques, we observed the distributions of PNA-BMs and S-100 in the soleus muscle. The overlap area of PNA-BMs and S-100 was measured with NIH image technique.
  
  
  RESULTS
  The extracellular matrix (ECM) recognized by PNA played an important role in guiding the sprouting and extending of the Schwann's cells. The agglomeration, sprouting and extension of the terminal Sc and the overlap area of Sc with PNA-BMs in the Yiqi Huayu Recipe group were better than those in the control group.
  
  
  CONCLUSIONS
  Yiqi Huayu Recipe can promote the growth of ECM and Schwann's cells and accelerate the nerve regeneration process.
authors.affiliation: Institute of Spinal Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. zhouchongjian11@sina.com
authors.forename: Chong-Jian
authors.initials: CJ
authors.lastname: Zhou
authors.forename: Jun-Ren
authors.initials: JR
authors.lastname: Su
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Wang
authors.forename: Bao-Xing
authors.initials: BX
authors.lastname: Hou
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007150:Immunohistochemistry; D008516:Medicine, Chinese Traditional; D018613:Microscopy, Confocal; D011843:Radiculopathy / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011975:Receptors, Mitogen / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism*; D012583:Schwann Cells / Q000187:drug effects* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D011975:Receptors, Mitogen; D009418:S100 Proteins; C038223:peanut agglutinin receptor