title: The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome.
abstract: The K121Q polymorphism of the plasma cell membrane glycoprotein 1 gene was significantly associated with polycystic ovary syndrome (PCOS) susceptibility, the pooled genotype distribution (K121K vs. 121Q allele) having an odds ratio of 1.90 (95% confidence interval 1.11-3.26). This suggests that impaired insulin signaling is of etiologic importance in PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland. seppo.heinonen@kuh.fi
authors.forename: Seppo
authors.initials: S
authors.lastname: Heinonen
authors.forename: Seija
authors.initials: S
authors.lastname: Korhonen
authors.forename: Seppo
authors.initials: S
authors.lastname: Helisalmi
authors.forename: Riitta
authors.initials: R
authors.lastname: Koivunen
authors.forename: Juha S
authors.initials: JS
authors.lastname: Tapanainen
authors.forename: Markku
authors.initials: M
authors.lastname: Laakso
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011755:Pyrophosphatases / Q000235:genetics*
chemical_list: D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases