title: Effect of a trifluoromethyl ketone on the motility of proton pump-deleted mutant of Escherichia coli strain and its wild-type.
abstract: We have recently found that 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone [TF18] exhibited the most potent antibacterial activity among 30 trifluoromethyl ketones against various prokaryotes, such as Escherichia coli (E. coli). In the present study, the inhibition of E. coli motility by TF18 was investigated. TF18 showed the lowest minimum inhibitory concentration (MIC) and highest inhibitory effect on the motility of E. coli strains. The wild-type E. coli was more sensitive to inhibition of motility than its proton pump-deleted mutant strain at subinhibitory concentrations. These data suggest that one of the targets of the antibacterial effect of the trifluoromethyl ketone is the proton pump system.
authors.affiliation: Department of Medical Microbiology, Faculty of General Medicine, University of Szeged, Hungary.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Molnár
authors.forename: Krisztina
authors.initials: K
authors.lastname: Wolfart
authors.forename: Masami
authors.initials: M
authors.lastname: Kawase
authors.forename: Noboru
authors.initials: N
authors.lastname: Motohashi
authors.forename: Joseph
authors.initials: J
authors.lastname: Molnár
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001583:Benzoxazoles / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D007659:Ketones / Q000494:pharmacology*; D009068:Movement / Q000187:drug effects* / Q000502:physiology; D009154:Mutation; D011407:Propane / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: C495691:1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone; D000900:Anti-Bacterial Agents; D001583:Benzoxazoles; D007659:Ketones; D011407:Propane