Enantioselective alkylation of beta-keto esters by phase-transfer catalysis using chiral quaternary ammonium salts.
Catalytic enantioselective alkylation promoted by a quaternary ammonium salt from cinchonine as a phase transfer catalyst is described. Treatment of cyclo beta-keto esters with alkyl halide under mild reaction conditions afforded the corresponding alpha-alkylated beta-keto esters in moderate to excellent yields with high enantiomeric excesses
Park
Eun Joo
EJ
Department of Chemistry, Soonchunhyang University, Asan P.O. Box 97, Chungnam 336-600, Korea.
Kim
Mi Hee
MH
Kim
Dae Young
DY