Immunomodulating and anti-tumor action of extracts of several mushrooms.
Aqueous extracts from fruit bodies and mycelia of various higher Basidiomycetes were studied in search for reliable biological effects. In vitro and in vivo experiments were conducted. The results showed that the aqueous extracts demonstrated various types of marked biological actions: an increased production of reactive oxygen forms by neutrophil cells of human peripheral blood; a significant mitogenic activity in a wide range of concentrations; stimulation on production of inflammatory cytokines interleukine 1-beta and interleukine-8 by peripheral blood cells; a decrease in both average tumor size in mice with transplanted melanoma B16 and a manifestation of tumorous intoxication; and a prolongation in the survival rate of such mice.
Shamtsyan
Mark
M
Department of Technology of Microbiological Synthesis, St. Petersburg State Institute of Technology (Technical University), 26 Moscovsky Pr., 198013, Russia. shamtsyan@yahoo.com
Konusova
Valentina
V
Maksimova
Yulia
Y
Goloshchev
Alexander
A
Panchenko
Andrey
A
Simbirtsev
Andrey
A
Petrishchev
Nikolay
N
Denisova
Nina
N
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012878:Skin Neoplasms / Q000188:drug therapy*
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species