Streptococcus pyogenes and human neutrophils: a paradigm for evasion of innate host defense by bacterial pathogens.
Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms. Although most invading bacteria are eliminated by PMNs, some have evolved complex strategies to prevent normal PMN function. This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms.
Voyich
Jovanka M
JM
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
Musser
James M
JM
DeLeo
Frank R
FR
D017209:Apoptosis; D006801:Humans; D007113:Immunity, Innate; D009504:Neutrophils / Q000276:immunology* / Q000382:microbiology / Q000502:physiology; D010587:Phagocytosis; D013290:Streptococcal Infections / Q000276:immunology / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000472:pathogenicity*