Severe sinus bradycardia after initiation of bupropion therapy: a probable drug-drug interaction with metoprolol.
Bupropion is an increasingly prescribed agent to aid in smoking cessation. However it has important drug-drug interactions related to the cytochrome P450 system. One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol.
McCollum
David L
DL
Department of Internal Medicine, The University of Texas-Southwestern Medical Center at Dallas, Dallas,Texas, USA. ren.mcguire@southwestern.edu
Greene
Jerica L
JL
McGuire
Darren K
DK
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D001146:Arrhythmia, Sinus / Q000139:chemically induced*; D001919:Bradycardia / Q000139:chemically induced*; D016642:Bupropion / Q000009:adverse effects*; D018765:Dopamine Uptake Inhibitors / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008790:Metoprolol / Q000009:adverse effects*; D008875:Middle Aged; D012720:Severity of Illness Index; D016540:Smoking Cessation
D000319:Adrenergic beta-Antagonists; D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D008790:Metoprolol