title: Physiologic-insensitive left ventricular assist predisposes right-sided circulatory failure: a pilot simulation and validation study.
abstract: Right-sided circulatory failure (RSCF) is a serious complication in 15-30% of patients receiving a left ventricular assist device (LVAD). It is hypothesized that left ventricular support which lacks physiologic properties predisposes to RSCF. An integral computer simulation and experimental validation protocol was performed. The results suggest that with conventional insensitive left ventricular support right-sided circulatory function is compromised, which may form a substrate for the onset or progress of RSCF. Feedback control of the LVAD could provide a means to counter this problem. A control concept for the LVAD which aims to preserve right-sided circulatory function, while supporting peripheral perfusion, is proposed
authors.affiliation: Department of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, Maastricht, the Netherlands.
authors.forename: Koen
authors.initials: K
authors.lastname: Reesink
authors.forename: André
authors.initials: A
authors.lastname: Dekker
authors.forename: Theo
authors.initials: T
authors.lastname: van der Nagel
authors.forename: Hans
authors.initials: H
authors.lastname: Blom
authors.forename: Cecile
authors.initials: C
authors.lastname: Soemers
authors.forename: Gijs
authors.initials: G
authors.lastname: Geskes
authors.forename: Jos
authors.initials: J
authors.lastname: Maessen
authors.forename: Erik
authors.initials: E
authors.lastname: van der Veen
mesh_terms: D001243:Assisted Circulation; D001698:Biomedical Engineering; D003198:Computer Simulation; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology; D006353:Heart-Assist Devices / Q000009:adverse effects / Q000592:standards*; D006801:Humans; D008955:Models, Cardiovascular; D010865:Pilot Projects; D011652:Pulmonary Circulation; D015203:Reproducibility of Results; D016277:Ventricular Function, Left / Q000502:physiology