Pharmacokinetics of selamectin in dogs after topical application.
Some pharmacokinetic parameters of selamectin were determined in male (n = 5) and female (n = 5) Beagle dogs following a topical application at a dose rate of 6 mg/kg. The plasma concentration versus time data for the drug were analysed using a one-compartment model. The maximum plasma concentrations of 12.72 +/- 5.13 ng/ml for males and 22.65 +/- 11.95 ng/ml for females occurred around 5 days after administration. The area under the concentration-time curve (AUC) was 192.08 +/- 63.85 ng.day/ml for males and 370.97 +/- 146.87 ng.day/ml for females. The mean residence time was the same in males and females (12.55 days). This study reveals a sex-influence on the disposition of selamectin in the plasma of dogs, which implies that further information will be needed for correlation with efficacy studies in dogs.
Dupuy
J
J
Laboratoire de Pharmacologie-Toxicologie, INRA, 180 Chemin de Tournefeuille, BP3, 31931 Toulouse Cedex 9, France.
Derlon
A L
AL
Sutra
J F
JF
Cadiergues
M C
MC
Franc
M
M
Alvinerie
M
M
D000287:Administration, Topical; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D004285:Dogs / Q000097:blood*; D005260:Female; D006207:Half-Life; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate
D000977:Antiparasitic Agents; D007559:Ivermectin; C414354:selamectin