[Distribution of tetracycline-arginine-glycine-aspartate-tyrosine in mice and its effect on bone].
OBJECTIVE
To investigate the distribution of tetracycline-arginine-glycine-aspartate-tyrosine (T-RGDY) in mice and its effect on bone.


METHODS
125-labeled T-RGDY was studied for its distribution in mice and for its effects on bone by histomorphometry in ovariectomized rats.


RESULTS
The 125I-labeled T-RGDY was more concentrated in the osteoporotic bone than in the normal bone. Compared with ovariectomy group, the morphologic index such as trabecular bone volume/total tissue volume (TBV/TTV), TBV/sponge bone volume (SBV), and mean trabecular plate thickness (MTPT) in T-RGDY group significantly increased (P < 0.05). As compared with sham operation group, MTPT significantly increased in T-RGDY group (P < 0.05), while TBV/SBV and mean trabecular plate density significantly decreased (P < 0.05), and TBV/TYV and mean trabecular plate spacing were almost the same as those in sham operation group (P > 0.05).


CONCLUSIONS
T-RGDY may concentrate in bone tissue to a certain degree, which is closely related with the status of bone remodeling. T-RGDY may inhibit the bone loss caused by ovariectomy.
Dai
Chen-lin
CL
Department of Endocrinology, the General Hospital of Tianjin Medical University, Tianjin 300052, China.
Ding
Xiao-ying
XY
Zhang
Xin
X
Chen
Kun-ming
KM
Zhang
Mo-ling
ML
Qiu
Ming-cai
MC
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects; D005260:Female; D051379:Mice; D009842:Oligopeptides / Q000493:pharmacokinetics* / Q000494:pharmacology; D010024:Osteoporosis / Q000378:metabolism* / Q000517:prevention & control; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013752:Tetracycline / Q000493:pharmacokinetics* / Q000494:pharmacology; D014018:Tissue Distribution; D014443:Tyrosine / Q000493:pharmacokinetics* / Q000494:pharmacology
D009842:Oligopeptides; D014443:Tyrosine; C047981:arginyl-glycyl-aspartic acid; D013752:Tetracycline