title: Detection and expression of Epstein-Barr Virus (EBV) DNA in tissues from penile tumors in Brazil.
abstract: Epstein-Barr Virus (EBV) is prevalent in all human populations and high titers of antibody correlate with specific malignancies such as Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease. Our study detected EBV DNA in 20 of 21 penile tumor samples using PCR reaction. Expression of EBV protein LMP-1 was identified in tumor cells from two EBV PCR-positive tumors. Our findings indicate that EBV can be implicated in rising and/or progression of penile tumors independently of the histological type.
authors.affiliation: Serviço de Hematologia, HC I, Instituto Nacional de Câncer, Pç. da Cruz Vermelha, 23, 8 andar, 20230-130 Rio de Janeiro, RJ, Brazil. gbrown@inca.gov.br
authors.forename: Gilda
authors.initials: G
authors.lastname: Alves
authors.forename: Camila Menezes Trindade
authors.initials: CM
authors.lastname: Macrini
authors.forename: Patrícia
authors.initials: P
authors.lastname: de Souza Nascimento
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Morais
authors.forename: Antonio Augusto
authors.initials: AA
authors.lastname: Ornellas
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000378:metabolism / Q000821:virology; D018289:Carcinoma, Verrucous / Q000453:epidemiology / Q000378:metabolism / Q000821:virology; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism*; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D010412:Penile Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D016133:Polymerase Chain Reaction; D014763:Viral Matrix Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D004279:DNA, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins