Regulation of apoptotic signal transduction pathways by the heat shock proteins.
The study about apoptotic signal transductions has become a project to reveal the molecular mechanisms of apoptosis. Heat shock proteins (hsps), which play an important role in cell growth and apoptosis, have attracted great attentions. A lot of researches have showed there is a hsps superfamily including hsp90, hsp70, hsp60 and hsp27, etc., which regulates the biological behaviors of cells, particularly apoptotic signal transduction in Fas pathway, JNK/SAPK pathway and caspases pathway at different levels, partly by the function of molecular chaperone.
Li
Zhengyu
Z
Department of Gynecology and Obstetrics, West China Second Hospital of Sichuan University, Chengdu 610041, China.
Zhao
Xia
X
Wei
Yuquan
Y
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D018832:Molecular Chaperones / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D020169:Caspases