title: [The obstructive sleep apnoea syndrome in obesity: a conspirator in the shadow].
abstract: The obstructive sleep apnoea syndrome (OSAS) is caused by upper airway collapse during sleep. These episodes are associated with recurrent oxyhaemoglobin desaturations and arousals which lead to disruption of the sleep pattern and cognitive deterioration. Factors such as age, male sex, menopause, tobacco and alcohol consumption and anatomic abnormalities are demonstrated risk factors for OSAS development. Obesity, specially of abdominal type, is also a very strong predictor of OSAS, increasing the risk of apnoea by ten times. OSAS prevalence may reach 80% and 50% en males and females with morbid obesity respectively. OSAS induces sympathoexcitation, insulin resistance, renin-angiotensin system activation, oxidative stress, endothelial dysfunction, hypercoagulability and reduction of fibrinolysis leading to hypertension and increased cardiovascular risk. The best diagnostic procedure is polysomnography. Obesity treatment is followed by a dramatic improvement in OSAS. Weight loss of 10% results in reductions of apnoea index by 26%. Application of a positive pressure system is a very effective treatment for OSAS which reduces the apnoea index and improves cardiovascular risk and cognitive impairment.
authors.affiliation: Departamento de Endocrinología y Nutrición, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona. jsalvador@unav.es
authors.forename: J
authors.initials: J
authors.lastname: Salvador
authors.forename: J
authors.initials: J
authors.lastname: Iriarte
authors.forename: C
authors.initials: C
authors.lastname: Silva
authors.forename: J
authors.initials: J
authors.lastname: Gómez Ambrosi
authors.forename: A
authors.initials: A
authors.lastname: Díez Caballero
authors.forename: G
authors.initials: G
authors.lastname: Frühbeck
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D018384:Oxidative Stress; D017286:Polysomnography; D015995:Prevalence; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D013564:Sympathetic Nervous System / Q000503:physiopathology; D019851:Thrombophilia / Q000453:epidemiology / Q000209:etiology; D015431:Weight Loss
chemical_list: D020738:Leptin
vernacular_title: El síndrome de apneas obstructivas del sueño en la obesidad: un conspirador en la sombra.