title: Idebenone in senile dementia of Alzheimer type: a multicentre study.
abstract: Idebenone is a new cerebro-active drug, effective in dementia disorders, particularly indicated in primary degenerative dementias, i.e. Alzheimer's disease. This new molecule acts as an electron trapper and a free radical scavenger protecting mitochondrial membranes from lipid peroxidation. A multicentric, double-blind trial of idebenone (45 mg twice daily orally) vs. placebo was carried out on 102 elderly patients affected by Alzheimer-type dementia of mild or moderate severity. Idebenone was administered for 4 consecutive months, 45 mg twice daily. Clinical evaluations were performed at the time of enrollment (t0) and monthly thereafter (t30, t60, t90 and t120) and at follow-up (t150 ). Tolerability to idebenone treatment was good and was associated with a statistically significant improvement of memory, attention and behaviour. It is worthwhile noting that these cognitive and behavioral findings were observed after the first month of treatment with enhancement evident in the following period.
authors.affiliation: Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Senin
authors.forename: L
authors.initials: L
authors.lastname: Parnetti
authors.forename: G
authors.initials: G
authors.lastname: Barbagallo-Sangiorgi
authors.forename: L
authors.initials: L
authors.lastname: Bartorelli
authors.forename: V
authors.initials: V
authors.lastname: Bocola
authors.forename: A
authors.initials: A
authors.lastname: Capurso
authors.forename: M
authors.initials: M
authors.lastname: Cuzzupoli
authors.forename: M
authors.initials: M
authors.lastname: Denaro
authors.forename: V
authors.initials: V
authors.lastname: Marigliano
authors.forename: A E
authors.initials: AE
authors.lastname: Tammaro
authors.forename: M
authors.initials: M
authors.lastname: Fioravanti