title: [Study on the relationship between Fas expression and apoptosis in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the relationship of Fas mRNA and protein expression and apoptosis in human oral squamous cell carcinoma.
  
  
  METHODS
  Northern blot and flow cytometry (TUNEL method) were used to detect the expression of Fas mRNA and Fas protein, cell cycle and apoptotic level in oral squamous cell carcinoma. The relationship between Fas gene expression and OSCC apoptosis was analyzed statistically.
  
  
  RESULTS
  Fas mRNA and protein could be detected in all five normal oral mucosa specimens. There was positive correlation between expression of Fas mRNA/protein and cell differentiation as well as apoptosis in OSCC (P < 0.005).
  
  
  CONCLUSIONS
  The expression of Fas gene was highly correlated with the differentiation and apoptosis in OSCC.
authors.affiliation: Dept. of Oral and Cranio-Maxillofacial Surgery, the Second Affiliated Hospital, Guanzhou 510120, China.
authors.forename: Jian-guang
authors.initials: JG
authors.lastname: Wang
authors.forename: Hong-zhang
authors.initials: HZ
authors.lastname: Huang
authors.forename: Chao-bin
authors.initials: CB
authors.lastname: Pan
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Hou
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Cheng
mesh_terms: D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D009062:Mouth Neoplasms / Q000378:metabolism*; D019014:fas Receptor / Q000378:metabolism*
chemical_list: C491901:FAS protein, human; D019014:fas Receptor