title: Longitudinal mapping of cortical thickness and brain growth in normal children.
abstract: Recent advances in magnetic resonance imaging (MRI) technology now allow the tracing of developmental changes in the brains of children. We applied computer-matching algorithms and new techniques for measuring cortical thickness (in millimeters) to the structural MRI images of 45 children scanned twice (2 yr apart) between the ages 5 and 11. Changes in brain size were also assessed, showing local brain growth progressing at a rate of approximately 0.4-1.5 mm per year, most prominently in frontal and occipital regions. Estimated cortical thickness ranged from 1.5 mm in occipital regions to 5.5 mm in dorsomedial frontal cortex. Gray matter thinning coupled with cortical expansion was highly significant in right frontal and bilateral parieto-occipital regions. Significant thickening was restricted to left inferior frontal (Broca's area) and bilateral posterior perisylvian (Wernicke's area on the left) regions. In the left hemisphere, gray matter thickness was correlated with changing cognitive abilities. For the first time, developmental changes in gray matter thickness, brain size, and structure-function relationships have been traced within the same individuals studied longitudinally during a time of rapid cognitive development.
authors.affiliation: Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095-1769, USA. esowell@loni.ucla.edu
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Sowell
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.forename: Christiana M
authors.initials: CM
authors.lastname: Leonard
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Welcome
authors.forename: Eric
authors.initials: E
authors.lastname: Kan
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
mesh_terms: D000328:Adult; D000367:Age Factors; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007807:Language Tests; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D012016:Reference Values; D013223:Statistics as Topic; D014888:Wechsler Scales