Synchrotron radiation small- and wide- angle scattering study of dispergation of Equoral, a novel drug delivery system with cyclosporine A.
Equoral oral solution is a novel drug delivery system for cyclosporine consisting mainly of non-ionic surfactants, polyglycerol esters and polyoxyethylated fatty acids aggregates, and gives microdispersions in the aqueous enviroment. To simulate dispergation, Equoral was mixed with varying amounts of water. Changes in the structure of the prepared aggregates were studied using synchrotron x-ray small- and wide-angle scattering. A lamellar phase is the most probable structure, arising spontaneously after dispergation of Equoral in the region of 30-70 wt% H2O.
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Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. uhrikova@fpharm.uniba.sk
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D016572:Cyclosporine / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000737:chemistry*; D012542:Scattering, Radiation; D017356:Synchrotrons; D014965:X-Rays
D007166:Immunosuppressive Agents; D016572:Cyclosporine