ACE1 polymorphism and progression of SARS.
We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p=0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.
Itoyama
Satoru
S
Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Japan.
Keicho
Naoto
N
Quy
Tran
T
Phi
Nguyen Chi
NC
Long
Hoang Thuy
HT
Ha
Le Dang
LD
Ban
Vo Van
VV
Ohashi
Jun
J
Hijikata
Minako
M
Matsushita
Ikumi
I
Kawana
Akihiko
A
Yanai
Hideki
H
Kirikae
Teruo
T
Kuratsuji
Tadatoshi
T
Sasazuki
Takehiko
T
D018450:Disease Progression; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D000860:Hypoxia / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011024:Pneumonia, Viral / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D011110:Polymorphism, Genetic; D045169:Severe Acute Respiratory Syndrome / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics*; D014744:Vietnam / Q000453:epidemiology
D007703:Peptidyl-Dipeptidase A