Age-related changes of TSH receptors in thyroid tissues obtained from euthyroid patients.
The results obtained in the comparative study of age-related changes in TSH binding by thyroid tissues of euthyroid patients indicated that the content of high affinity binding sites of TSH receptors is not significantly decreased during aging, while the level of low affinity binding sites is increased in thyroid tissues of aged people. However, the dissociation constant of low affinity binding sites for TSH is significantly increased in thyroid tissues of old patients, compared with middle-aged people. Further investigation of functional characteristics of observed changes in TSH receptors and their binding parameters will provide a better understanding of the mechanism involved in the regulation of thyroid gland function during the aging.
Durica
S
S
Internal Clinic of Zvezdara of Clinical University Centre, Belgrade, Yugoslavia.
Zakula
Z
Z
Isenović
E
E
Ribarac-Stepić
N
N