title: Short synthesis of polyoxygenated macrocyclic rings using acetal linkages. Application to the preparation of a new lipidic polyamine.
abstract: A short preparation of polyoxygenated macrocycles can be carried out by combining the formation of an acetal linkage, to introduce long alkyl chains, with a ring closure metathesis. As an example, this methodology was used to synthesize a new polyamino lipid.
authors.affiliation: Laboratoire de Pharmacologie Chimique et Génétique U640 INSERM - UMR 8151 CNRS ENSCP 11 rue Pierre et Marie Curie 75231 Paris Cedex.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Miramon
authors.forename: Nathalie
authors.initials: N
authors.lastname: Mignet
authors.forename: Jean
authors.initials: J
authors.lastname: Herscovici
mesh_terms: D000080:Acetals / Q000737:chemistry*; D005822:Genetic Vectors / Q000138:chemical synthesis; D008055:Lipids / Q000138:chemical synthesis*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis*
chemical_list: D000080:Acetals; D008055:Lipids; D047028:Macrocyclic Compounds; D011073:Polyamines