title: [A software program for quantitative analysis of alveolar oxygen partial pressure (p(A)O(2)) with oxygen-sensitive (3)He-MRI].
abstract: OBJECTIVE
  To develop a software tool for quantitative analysis of alveolar oxygen partial pressure (p(A)O(2)) as well as its time course during apnea.
  
  
  METHODS
  T (1)-relaxation times of hyperpolarized (3)He are reduced by paramagnetic oxygen rendering (3)He-MRI sensitive to oxygen and thus allowing the assessment of the local oxygen partial pressure in the pulmonary airspaces. Oxygen-related relaxation and loss of polarization by RF-excitation can be discriminated by acquiring two image series with varying interscan delay and/or flip angles. Software was developed to calculate the p(A)O(2) and the decay rate in user-defined regions of interest (ROIs) automatically. Moreover, parameter maps can be calculated. In addition to the analysis of 2-dimensional data sets, the software allows the evaluation of 3-dimensional measurements for the first time. Artifacts due to lung motion were reduced by implementing a motion correction algorithm.
  
  
  RESULTS
  The software was successfully applied to data sets from healthy volunteers and from patients with various lung diseases. The parameter maps demonstrated a more homogeneous distribution of p(A)O(2) for the volunteers than for the patients. A regional increase in p(A)O(2) was found in a few patients.
  
  
  CONCLUSIONS
  The described software allows the absolute quantification of p(A)O(2) as well as its variation over time. In the future, therefore, the software may gain importance for detecting mismatches between ventilation and perfusion, e. g., in patients with pulmonary embolism or chronic obstructive lung diseases.
authors.affiliation: Klinik und Poliklinik für Radiologie, Johannes Gutenberg-Universität, Mainz.
authors.forename: F
authors.initials: F
authors.lastname: Lehmann
authors.forename: B
authors.initials: B
authors.lastname: Eberle
authors.forename: K
authors.initials: K
authors.lastname: Markstaller
authors.forename: K K
authors.initials: KK
authors.lastname: Gast
authors.forename: J
authors.initials: J
authors.lastname: Schmiedeskamp
authors.forename: P
authors.initials: P
authors.lastname: Blümler
authors.forename: H-U
authors.initials: HU
authors.lastname: Kauczor
authors.forename: W G
authors.initials: WG
authors.lastname: Schreiber
mesh_terms: D000328:Adult; D002908:Chronic Disease; D006371:Helium; D006801:Humans; D007554:Isotopes; D008168:Lung / Q000502:physiology*; D008171:Lung Diseases / Q000175:diagnosis / Q000503:physiopathology*; D008173:Lung Diseases, Obstructive / Q000175:diagnosis / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D008962:Models, Theoretical; D010100:Oxygen / Q000032:analysis*; D010313:Partial Pressure; D011650:Pulmonary Alveoli / Q000502:physiology; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000503:physiopathology; D012119:Respiration; D012984:Software
chemical_list: D007554:Isotopes; D006371:Helium; D010100:Oxygen
vernacular_title: Ein Auswerteprogramm zur quantitativen Analyse von Messungen des alveolären Sauerstoffpartialdrucks (p(A)O(2)) mit der sauerstoffsensitiven (3)He-MR-Tomographie.