Applying proteomics to signaling networks.
The information from genome sequencing provides a new framework for a systems-wide understanding of protein networks and cellular function. Whereas microarray technologies provide information about global gene expression within cells, complementary proteomic strategies monitor expression of proteins and their posttranslational modifications. Improved technologies that have emerged for comprehensive and high-throughput protein analysis yield novel insights into cell regulation.
Kabuyama
Yukihito
Y
Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA.
Resing
Katheryn A
KA
Ahn
Natalie G
NG
D000818:Animals; D006801:Humans; D040081:Protein Array Analysis; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction