Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth.
The Drosophila Sterile-20 kinase Slik promotes tissue growth during development by stimulating cell proliferation and by preventing apoptosis. Proliferation within an epithelial sheet requires dynamic control of cellular architecture. Epithelial integrity fails in slik mutant imaginal discs. Cells leave the epithelium and undergo apoptosis. The abnormal behavior of slik mutant cells is due to failure to phosphorylate and activate Moesin, which leads to excess Rho1 activity. This is distinct from Slik's effects on cell proliferation, which are mediated by Raf. Thus Slik acts via distinct pathways to coordinate cell proliferation with epithelial cell behavior during tissue growth.
Hipfner
David R
DR
European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Keller
Nadine
N
Cohen
Stephen M
SM
D000199:Actins / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000254:growth & development*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D047908:Intracellular Signaling Peptides and Proteins; D007814:Larva; D020930:MAP Kinase Kinase Kinases; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008871:Microvilli / Q000235:genetics; D009154:Mutation; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D014921:Wings, Animal / Q000166:cytology / Q000254:growth & development; D020741:rho GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D000099317:Hippo Kinases
D000199:Actins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D020930:MAP Kinase Kinase Kinases; D008840:Microfilament Proteins; D017346:Protein Serine-Threonine Kinases; D029701:Saccharomyces cerevisiae Proteins; D020741:rho GTP-Binding Proteins; C071058:moesin; C492662:Slik protein, Drosophila; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases; C078754:STE20 protein, S cerevisiae; C511153:Rho1 protein, Drosophila