New nardosinanes and 19-oxygenated ergosterols from the soft coral Nephthea armata collected in Taiwan.
Five new nardosinane sesquiterpenoids, armatins A-E, lemnal-1(10)-ene-2,12-dione (a new natural product), and two new cytotoxic 19-oxygenated ergosterols, armatinols A and B, were isolated from the methylene chloride extract of the soft coral Nephthea armata, collected in Taiwan. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity was determined against selected cancer cells.
El-Gamal
Ali A H
AA
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Wang
Shang-Kwei
SK
Dai
Chang-Feng
CF
Duh
Chang-Yih
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C493067:armatinol A; C493068:armatinol B; C493069:lemnal-1(10)-ene-2,12-dione; D004875:Ergosterol