Different response of brain cholecystokinin content to intragastric administration of trypsin inhibitor (camostate) in young and old rats.
The tissue concentrations of cholecystokinin in the intestine and the brain in young (4-8-month-old), and old (26-29-month-old) rats before and after intragastric administration of synthetic trypsin inhibitor (camostate) were examined. The total cholecystokinin content in the proximal intestine was significantly higher in old rats, whereas that in the brain was similar in young and old rats. Intragastric administration of camostate significantly increased the plasma cholecystokinin concentration and decreased the intestinal cholecystokinin content in both young and old rats. It also decreased the cholecystokinin content in the brain of old rats but not of young rats. These results suggest that the effect of aging on changes in the tissue content of cholecystokinin varies in different tissues.
Miyasaka
K
K
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173, Japan.
Matsumoto
M
M
Tomita
H
H
Sazaki
N
N
Okubo
K
K
Shikado
F
F
Funakoshi
A
A