Nuclear factor-kappaB: the enemy within.
Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-kappaB. NF-kappaB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis. Constitutively activated NF-kappaB is common in wide variety of tumors. Furthermore, there exists genetic evidence that NF-kappaB mediates tumorigenesis. Thus, suppression of NF-kappaB activation should be effective in the prevention and treatment of cancer.
Aggarwal
Bharat B
BB
Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. aggarwal@mdanderson.org
D017209:Apoptosis; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000209:etiology; D016328:NF-kappa B / Q000502:physiology*; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic; D009857:Oncogenes
D016328:NF-kappa B