title: EK-2612, a new cyclohexane-1,3-dione possessing selectivity between rice (Oryza sativa) and barnyardgrass (Echinochloa crus-galli).
abstract: A newly synthesized experimental compound, EK-2612 is one of the class of cyclohexane-1,3-diones which are commonly known to be grasskillers. A greenhouse study was conducted to evaluate the herbicidal performances of EK-2612 on several grass species in comparison with tralkoxydim, a commercialized cyclohexanedione derivative. Like tralkoxydim, the compound EK-2612 showed excellent control efficacy on most grass weeds tested through foliar application rates between 250 and 63 g AI ha(-1). Unlike tralkoxydim, however, EK-2612 showed a good rice safety, and there was no rice damage observed at the level below 125 g AI ha(-1), while rice injury developed at the same application rates of tralkoxydim. With this rice safety, EK-2612 controlled barnyardgrass effectively up to the two-leaf stage under both submerged and dried paddy conditions. An in vitro ACCase assay indicated that EK-2612 is a strong ACCase inhibitor; however, the dose-response was not substantially different in rice and barnryardgrass, showing I50 values of 0.1 and 0.12 microM, respectively. These results suggest that the compound EK-2612 is targeting plant ACCase, but the whole-plant rice safety is not attributable to a different inhibition of the target site in rice from that in barnyardgrass.
authors.affiliation: Bio-Function Research Team, Korea Research Institute of Chemical Technology, PO Box 107, Taejon 305-606, Korea. tjkim@pado.krict.re.kr
authors.forename: Tae-Joon
authors.initials: TJ
authors.lastname: Kim
authors.forename: Jin-Seog
authors.initials: JS
authors.lastname: Kim
authors.forename: Kyoung Sik
authors.initials: KS
authors.lastname: Hong
authors.forename: In-Taek
authors.initials: IT
authors.lastname: Hwang
authors.forename: Kyoung Mahn
authors.initials: KM
authors.lastname: Kim
authors.forename: Hyeong-Rae
authors.initials: HR
authors.lastname: Kim
authors.forename: Kwang Yun
authors.initials: KY
authors.lastname: Cho
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors; D001572:Benzofurans / Q000737:chemistry / Q000633:toxicity*; D003512:Cyclohexanones / Q000737:chemistry / Q000633:toxicity*; D031747:Echinochloa / Q000187:drug effects*; D006540:Herbicides / Q000737:chemistry / Q000633:toxicity*; D007097:Imines / Q000737:chemistry / Q000633:toxicity; D012275:Oryza / Q000187:drug effects*; D013045:Species Specificity
chemical_list: C494053:2-(1-(allyloxyimino)propyl)-3-hydroxy-5-(1-(2,3-dihydro-2,2,4,6,7-pentamethylbenzofuran-5-yl))cyclohex-2-en-1-one; D001572:Benzofurans; D003512:Cyclohexanones; D006540:Herbicides; D007097:Imines; C494054:tralkoxydim; C004636:1,3-cyclohexanedione; D000103:Acetyl-CoA Carboxylase