title: Hypoxia simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor production by cultured human endometrial stromal cells.
abstract: Hypoxia downregulated the concentration of endostatin in the culture media of human endometrial stromal cells but did not affect the messenger (m)RNA expression of collagen XVIII. Both mRNA and protein expression of vascular endothelial growth factor were upregulated in a hypoxic condition.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama-machi, Oita 879-5593, Japan. nasu@med.oita-u.ac.jp
authors.forename: Kaei
authors.initials: K
authors.lastname: Nasu
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nishida
authors.forename: Junichiro
authors.initials: J
authors.lastname: Fukuda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawano
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishida
authors.forename: Isao
authors.initials: I
authors.lastname: Miyakawa
mesh_terms: D000328:Adult; D015687:Cell Hypoxia / Q000502:physiology*; D002478:Cells, Cultured; D004717:Endometrium / Q000473:pathology*; D043169:Endostatins / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D017697:Premenopause; D012333:RNA, Messenger / Q000235:genetics; D017154:Stromal Cells / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D043169:Endostatins; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A