title: [Characteristics of a clinical course of immune cytopenias with a high titer of autoantibodies to the microsomal antigen of the thyroid gland].
abstract: OBJECTIVE
  To ascertain the role of high antibodies (Ab) titers to microsomal antigen (MA) of the thyroid in clinical manifestations of cytopenic syndromes.
  
  
  METHODS
  Clinical data are presented on 144 patients with depressed hemopoiesis having different levels of thyroid Aab.
  
  
  RESULTS
  When the titer was significantly elevated (41% patients with immune cytopenias), hematological malignancies run with recurrences, remission is rare. Treatment of the thyroid pathology improves hematological indices in some cases though does not reduce titers of Ab thyroid MA.
  
  
  CONCLUSIONS
  Detection of autoimmune pathology of the thyroid is necessary not only for specification of the concurrent process diagnosis but also for initiation of adequate combined treatment.
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Vinogradova
authors.forename: A P
authors.initials: AP
authors.lastname: Shinkarkina
authors.forename: D L
authors.initials: DL
authors.lastname: Vinogradov
authors.forename: A M
authors.initials: AM
authors.lastname: Poverennyĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology*; D003038:Cobamides / Q000172:deficiency; D005260:Female; D006402:Hematologic Diseases / Q000097:blood / Q000276:immunology*; D006410:Hematopoiesis; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D033862:Iron-Binding Proteins / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000276:immunology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D003038:Cobamides; D033862:Iron-Binding Proteins; C056658:TPO protein, human; D007453:Iodide Peroxidase
vernacular_title: Osobennosti klinicheskogo techeniia immunnykh tsitopeniĭ, soprovozhdaiushchikhsia povyshennym titrom autoantitel k mikrosomal'nomu antigenu shchitovidnoĭ zhelezy.