Facile synthesis of 2-substituted 1,2-dihydro-1-naphthols and 2-substituted 1-naphthols.
[reaction: see text] The palladium-catalyzed ring opening of dimethoxy oxabenzonorbornadiene with aryl or vinyl halides occurred under very mild conditions to give substituted 1,2-dihydronaphthols that were oxidized with IBX to furnish substituted naphthols in excellent overall yields.
Chen
Chi-Li
CL
Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA.
Martin
Stephen F
SF
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D009284:Naphthols / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*
D009284:Naphthols; D010165:Palladium