title: A noninvasive partial carbon dioxide rebreathing technique for measurement of pulmonary capillary blood flow is also a useful oxygenation monitor during one-lung ventilation.
abstract: OBJECTIVE
  To test the hypothesis that effective pulmonary capillary blood flow can be a useful indicator for estimating appropriate oxygenation and ventilation during one-lung ventilation in lung surgery.
  
  
  METHODS
  Prospective data analysis.
  
  
  METHODS
  A 770-bed general teaching hospital.
  
  
  METHODS
  15 ASA physical status II and III patients undergoing elective lung surgery.
  
  
  METHODS
  Patients received general and thoracic epidural anesthesia and underwent lung operation with one-lung ventilation.
  
  
  METHODS
  We measured effective pulmonary capillary blood flow by a partial CO2 rebreathing method and oxygenation parameters during two-lung ventilation before surgery, during one-lung ventilation, and during two-lung ventilation after lung surgery.
  
  
  RESULTS
  The effective pulmonary capillary blood flow index significantly decreased by 31.6%, which was associated with a significant decrease in arterial oxygen tension (PaO2). The pulmonary shunt fraction increased to 46.3% during one-lung ventilation. During two-lung ventilation, after chest closure, effective pulmonary capillary blood flow index divided by heart rate (i.e., effective pulmonary blood stroke flow index) was still significantly lower than that seen during two-lung ventilation before thoracotomy. There were significant correlations between effective pulmonary capillary blood flow, pulmonary blood stroke flow index, and PaO2.
  
  
  CONCLUSIONS
  Effective pulmonary capillary blood flow index and effective pulmonary blood stroke flow index are useful indicators for determining appropriate oxygenation therapy during one-lung ventilation.
authors.affiliation: Department of Anesthesiology and Pain Clinic, Seirei-Mikatabara General Hospital, Hamamatsu, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujii
authors.forename: Mutsuhito
authors.initials: M
authors.lastname: Kikura
authors.forename: Tomosue
authors.initials: T
authors.lastname: Takada
authors.forename: Shigeru
authors.initials: S
authors.lastname: Katoh
authors.forename: Nao
authors.initials: N
authors.lastname: Aoyama
authors.forename: Shigehito
authors.initials: S
authors.lastname: Sato
mesh_terms: D000368:Aged; D002196:Capillaries / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism*; D002302:Cardiac Output; D005260:Female; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000627:therapeutic use*; D011652:Pulmonary Circulation; D012121:Respiration, Artificial
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen