title: [Rofecoxib versus non-steroidal anti-inflammatory drugs in arthrosis treatment: cost-effectiveness analysis for Spain].
abstract: OBJECTIVE
  Analyze the efficiency of non-selective non-steroidal anti-inflammatory drugs (NSAIDs) versus rofecoxib prescription for arthrosis treatment in Spain through a theoretical model of cost-effectiveness.
  
  
  METHODS
  A theoretical model of decision that evaluates the efficiency of the use of non-selective NSAIDs and rofecoxib in the treatment of patients > 65 years with arthrosis who were nonrespondent to the administration of acetaminophen 4 g/day. The analysis focuses on the estimate of the impact derived from the gastrointestinal (GI) adverse effects. Two alternative analysis contexts are considered: "customary clinical practice" and "rational use of GI drugs" with possible preventive use of gastroprotective (GP) drugs in both groups. The time horizon is 1 year. Direct expenses are estimated from the Spanish Health System perspective. The effectiveness parameter used is the number of severe GI complications prevented.
  
  
  RESULTS
  Under the assumptions of the first context, with a 55% estimated combinated prescription of non-selective GP with NSAID, and 6% with rofecoxib, the percentage of cost compensation of rofecoxib is 72%. Under the assumptions of the second context, the cost of rofecoxib is totally compensated when the percentage of combinated prescription of GP with NSAIDs is 59%.
  
  
  CONCLUSIONS
  The use of rofecoxib can be a cost-effective alternative with regard to the traditional non-selective NSAID in the arthrosis treatment, especially in context of higher preventive use of CI drugs.
authors.affiliation: Servicio de Reumatología, Hospital Universitario Virgen Macarena, Sevilla. rafariza@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Ariza-Ariza
authors.forename: B
authors.initials: B
authors.lastname: Hernández-Cruz
authors.forename: F
authors.initials: F
authors.lastname: Navarro-Sarabia
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000191:economics / Q000627:therapeutic use; D003365:Costs and Cost Analysis; D006801:Humans; D007783:Lactones / Q000191:economics* / Q000627:therapeutic use; D018803:Models, Economic; D010003:Osteoarthritis / Q000188:drug therapy / Q000191:economics*; D013450:Sulfones
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib
vernacular_title: Rofecoxib frente a antiinflamatorios no esteroideos en el tratamiento de la artrosis: análisis coste-efectividad para España.