Cellular stress and signal transduction responses to human cytomegalovirus infection.
Human cytomegalovirus (HCMV) receptor-ligand interactions and viral entry excite cellular responses such as receptor tyrosine kinase and mitogen-activated protein kinase signaling, cytoskeletal rearrangement, and the induction of transcription factors, prostaglandins, and cytokines. Bi-phasic stimulation of these pathways, excepting interferon, facilitates productive viral infection and likely contributes to viral pathogenesis.
Evers
David L
DL
Lineberger Comprehensive Cancer Center, CB No. 7295, Room 32-026, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
Wang
Xin
X
Huang
Eng-Shang
ES
D002460:Cell Line; D016207:Cytokines / Q000378:metabolism; D003587:Cytomegalovirus / Q000472:pathogenicity* / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000382:microbiology; D005786:Gene Expression Regulation; D018869:Heat-Shock Response; D006801:Humans; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D016207:Cytokines; D011506:Proteins