title: [Clinical study on effect of tongluo capsule in treating diabetic nephropathy caused chronic renal failure].
abstract: OBJECTIVE
  To observe the therapeutic effect of Tongluo capsule (TLC) in treating diabetic nephropathy (DN) complicated chronic renal failure (CRF), and to explore its mechanism preliminarily.
  
  
  METHODS
  Ninety-seven patients with DN-CRF were randomly divided into the TCM group (n = 50) and the WM group (n = 47) to observe the changes of urinary protein per 24 hrs (UP/24h), renal function, creatinine (Cr), blood urea nitrogen (BUN), blood lipids (TG, TC, HDL-C, LDL-C) and serum transforming growth factor-beta1 (TGF-beta1) before and after treatment.
  
  
  RESULTS
  After 6 months of treatment, levels of UP/24h, Cr, BUN and TGF-beta1 significantly lowered in both groups (P<0.01), and a better effect was showed in the TCM group in aspects of lowering Cr, BUN and TGF-beta1 (P<0.01). Besides, TLC also showed effect in lowering the serum lipid parameters (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  Effect of TLC in treating DN-CRF might be through lowering the levels of blood lipids and serum TGF-beta1.
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, The Second Hospital of Xi'an Jiaotong University, Xi'an (710004).
authors.forename: Wan-sen
authors.initials: WS
authors.lastname: Sun
authors.forename: Xi-li
authors.initials: XL
authors.lastname: Wu
authors.forename: Cheng-lin
authors.initials: CL
authors.lastname: Qiao
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000188:drug therapy; D001806:Blood Urea Nitrogen; D002214:Capsules; D003404:Creatinine / Q000097:blood; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000209:etiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D014059:Tongue; D016212:Transforming Growth Factor beta / Q000097:blood; D053773:Transforming Growth Factor beta1
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D008055:Lipids; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D003404:Creatinine