Antitoxins: novel strategies to target agents of bioterrorism.
Never before has there been such a strong possibility that biological agents might be used indiscriminately on civilian populations. This review focuses on the use of antitoxins - antibodies, receptor decoys, dominant-negative inhibitors of translocation, small-molecule inhibitors and substrate analogues - to counteract those biological weapons for which toxins are an important mechanism of disease pathogenesis.
Rainey
G Jonah A
GJ
Infectious Disease Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037-1099, USA.
Young
John A T
JA
D000942:Antigens, Bacterial / Q000378:metabolism / Q000633:toxicity; D000992:Antitoxins / Q000494:pharmacology* / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000633:toxicity; D023482:Bioterrorism; D001905:Botulinum Toxins / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D012276:Ricin / Q000037:antagonists & inhibitors / Q000633:toxicity; D014118:Toxins, Biological / Q000378:metabolism / Q000633:toxicity*
D000942:Antigens, Bacterial; D000992:Antitoxins; D001427:Bacterial Toxins; D014118:Toxins, Biological; C030325:anthrax toxin; D012276:Ricin; D001905:Botulinum Toxins