Thrombocytosis in pediatric HIV infection.
Thrombocytopenia has been extensively reported in association with HIV infection. Twenty-four children (6%) from a cohort of 400 children with platelet counts >500,000/mm(3) were reviewed. All had symptomatic disease and 10 (42%) patients died. In 4 children the platelet count exceeded 700,000/mm(3) and in 1 patient the platelet count was 1.5 million/mm(3). There were no thrombotic complications, and no specific therapy was required for the thrombocytosis. Thus HIV-1 infection, a chronic viral infection, is another etiologic agent for thrombocytosis and is associated with severe disease.
Ellaurie
Maadhava
M
Department of Meidcine, Pennsylvania State University, Hershey Medical Center, Hershey, PA 17033, USA.
D002675:Child, Preschool; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D013922:Thrombocytosis / Q000209:etiology*