Efficient preparation of glycoclusters from silsesquioxanes.
[structure: see text] A new type of glycocluster based on polyhedral oligosilsesquioxanes (POSS) has been efficiently prepared from unprotected mannoside and lactoside employing a convergent approach of thiol-radical addition reaction. The versatility of this approach was demonstrated by functionalization of mannosides and lactosides of different-length spacers.
Gao
Yongjun
Y
Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
Eguchi
Atsuko
A
Kakehi
Kazuaki
K
Lee
Yuan C
YC
D020650:Combinatorial Chemistry Techniques; D006023:Glycoproteins / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry*; D006801:Humans; D008362:Mannosides / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017646:Organosilicon Compounds / Q000737:chemistry*
D006023:Glycoproteins; D006027:Glycosides; D008362:Mannosides; D009844:Oligosaccharides; D017646:Organosilicon Compounds; C008245:lactosides