title: Botulinum toxin A: a 9-month clinical and 3D in vivo profilometric crow's feet wrinkle formation study.
abstract: OBJECTIVE
  The objective of this study was to determine the duration of the effects of a defined dose of BTX-A on crow's feet formation wrinkles.
  
  
  METHODS
  Twenty-five patients each received one injection of 12 units of BTX-A in the orbicularis oculi muscle on both sides of the face. The results were evaluated at 3, 6 and 9 months. Standardized photographs were taken of the wrinkle formations at rest at each step of the 9-month period following the treatment, and the wrinkles were then rated on photographs by blinded observers. Three-dimensional (3D) in vivo profilometry was also used to quantify the degree of improvement.
  
  
  RESULTS
  Both the self-assessments by the patients themselves and the objective assessments of the 3D profilometry study provided similar results, but the independent observer assessment results were slightly more optimistic. There was a statistically significant difference observed between baseline and the evaluations at both 3 and 6 months.
  
  
  CONCLUSIONS
  BTX-A is a safe and effective method for treating crow's feet wrinkles. In both the observer assessment and the 3D skin profilometric assessment, a clear improvement was shown at 6 months.
authors.affiliation: Centre Laser Dermatologique, Marseille, France. laserder@jeanluclevy.com
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Levy
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Servant
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Jouve
mesh_terms: D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D011446:Prospective Studies; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A