title: Muscle dysfunction versus wear and tear as a cause of exercise related osteoarthritis: an epidemiological update.
abstract: There are two main hypotheses for the cause of exercise related osteoarthritis: wear and tear of the articular cartilage and muscle dysfunction. This is a review of the clinical literature to see which hypothesis has the greatest support. Clinical studies support the muscle dysfunction hypothesis over the wear and tear hypothesis.
authors.affiliation: Lady David Institute for Medical Research, Centre for Clinical Epidemiology and Community Studies, SMBD-Jewish General Hospital, 3755 Cote Sainte-Catherine Road, Montreal H3T 1E2, Canada. ian.shrier@mcgill.ca
authors.forename: Ian
authors.initials: I
authors.lastname: Shrier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001265:Athletic Injuries / Q000150:complications* / Q000503:physiopathology; D002358:Cartilage, Articular / Q000293:injuries* / Q000503:physiopathology; D004812:Epidemiologic Methods; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000150:complications* / Q000503:physiopathology; D010003:Osteoarthritis / Q000209:etiology* / Q000503:physiopathology; D012420:Running / Q000293:injuries; D012916:Soccer / Q000293:injuries