Preparation and radiolabeling of human serum albumin (HSA)-coated magnetite nanoparticles for magnetically targeted therapy.
In this paper, we describe the preparation of human serum albumin-coated magnetic particles of about 200 nm in diameter with narrow size distribution radiolabeled with 188Re for the purpose of magnetically targeted therapy. The optimum radiolabeling conditions are: SnCl2 x 2H2O 8 mg/ml, citric acid 20 mg/ml, vitamin C 8 mg/ml, labeling volume 500 microl and a reaction time of 3 h. The stability of the radiolabeled particles is suitable for in vivo study.
Chunfu
Zhang
Z
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 2019 Baojia Road, Jiading, Shanghai 201800, China. zchunfu@yahoo.com.cn
Jinquan
Cao
C
Duanzhi
Yin
Y
Yongxian
Wang
W
Yanlin
Feng
F
Jiajü
Tan
T
D000327:Adsorption; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D004355:Drug Stability; D052203:Ferrosoferric Oxide; D007501:Iron / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D010572:Pest Control, Biological; D011868:Radioisotopes / Q000008:administration & dosage* / Q000737:chemistry*; D011878:Radiotherapy / Q000379:methods; D012211:Rhenium; D012709:Serum Albumin / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D010087:Oxides; D011868:Radioisotopes; D012709:Serum Albumin; D012211:Rhenium; D007501:Iron; D052203:Ferrosoferric Oxide