title: How do prokaryotic cells cycle?
abstract: This issue of Current Biology features five reviews covering various key aspects of the eukaryotic cell cycle. The topics include initiation of chromosome replication, assembly of the mitotic spindle, cytokinesis, the regulation of cell-cycle progression, and cell-cycle modeling, focusing mainly on budding yeast, fission yeast and animal cell model systems. The reviews underscore common themes as well as key differences in the way these processes are carried out and regulated among the different model organisms. Consequently, an important question is how cell-cycle mechanisms and controls have evolved, particularly in the broader perspective of the three domains of life.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of Texas Medical School, 6431 Fannin Street, Houston, Texas 77030, USA.
authors.forename: William
authors.initials: W
authors.lastname: Margolin
authors.forename: Rolf
authors.initials: R
authors.lastname: Bernander
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology; D005075:Biological Evolution; D002453:Cell Cycle / Q000502:physiology*; D020090:Chromosome Segregation / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D008954:Models, Biological; D011387:Prokaryotic Cells / Q000166:cytology* / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria