[Cyclooxygenase-2 inhibitors in postoperative pain management].
Management of acute postoperative pain remains suboptimal; nearly 80 % of the patients report moderate to extreme pain following surgery. Nonselective nonsteroidal antiinflammatory drugs (NSAIDs) have a role in postoperative pain management, but conventional NSAIDs can cause gastrointestinal ulceration, renal injury, and disruption of platelet function and hemostasis. Recently, cyclooxygenase-2 (COX-2) specific inhibitors such as rofecoxib and celecoxib were developed to provide the increased efficacy of non-specific NSAIDs while limiting associated side effects. These drugs have demonstrated analgesic efficacy and opioid sparing effect after variety of surgical procedures. This article will review the role and outcome of COX-2 inhibitors for postoperative pain management.
Güneş
Yasemin
Y
Cukurova University Faculty of Medicine, Department of Anesthesiology, Adana, Turkey. ygunes@cu.edu.tr
Işik
Geylan
G
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007783:Lactones / Q000627:therapeutic use; D010149:Postoperative Pain / Q000517:prevention & control*; D011720:Pyrazoles; D013449:Sulfonamides / Q000627:therapeutic use; D013450:Sulfones
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D011720:Pyrazoles; D013449:Sulfonamides; D013450:Sulfones; C116926:rofecoxib; D000068579:Celecoxib
Postoperatif ağri tedavisinde siklooksijenaz-2 inhibitörleri.