A patient with Glanzmann's thrombasthenia for emergent abdominal surgery.
Glanzmann's thrombasthenia is a rare autosomal recessive disease characterized by potentially major mucocutaneous complications and nose bleeds. It is considered hazardous for these surgical patients to conceive, with a high risk of urgent surgery. The treatment of bleeding or prevention of hemorrhage for surgery or invasive procedures is based on platelet transfusion. However, platelet transfusions may be responsible for the development of alloimmunization, with a high risk of future platelet refractoriness. We report a surgical case of Glanzmann's thrombasthenia complicated by nasopharyngeal bleeding and managed with platelet transfusions, recombinant activated factor VII, and postoperative airway management in the intensive care unit.
Uzunlar
Halil Ibrahim
HI
Department of Anesthesiology and Reanimation, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
Eroglu
Ahmet
A
Senel
Ahmet Can
AC
Bostan
Habib
H
Erciyes
Nesrin
N
D015746:Abdominal Pain / Q000601:surgery; D000328:Adult; D000768:Anesthesia, General; D001062:Appendectomy; D001065:Appendix / Q000601:surgery*; D001760:Bleeding Time; D003422:Critical Care; D004844:Epistaxis / Q000628:therapy; D005167:Factor VII / Q000627:therapeutic use; D005734:Gangrene / Q000601:surgery*; D006801:Humans; D007813:Laparotomy; D008297:Male; D010983:Plateletpheresis; D011994:Recombinant Proteins / Q000627:therapeutic use; D013915:Thrombasthenia / Q000150:complications*
D011994:Recombinant Proteins; D005167:Factor VII