title: Development of Parkinson's disease in patients with blepharospasm.
abstract: The liability to develop parkinsonian symptoms was evaluated in 105 outpatients with idiopathic blepharospasm (IBS; 54 cases) or IBS associated to oromandibular dystonia (Meige's syndrome; 51 cases) mean age 70.3 +/- 9.6 years, and compared with an age- and sex-matched population. Eleven patients developed Parkinson's disease in the blepharospasm group, whereas only 2 of 105 patients were affected in the control group. Our results suggest that patients with IBS either isolated or associated with oromandibular dystonia are more prone to develop parkinsonian symptoms.
authors.affiliation: Programa de Parkinson y Movimientos Anormales, Instituto de Neurociencias, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina. fmicheli@fibertel.com.ar
authors.forename: Federico
authors.initials: F
authors.lastname: Micheli
authors.forename: María Clara
authors.initials: MC
authors.lastname: Scorticati
authors.forename: Silvia
authors.initials: S
authors.lastname: Folgar
authors.forename: Emilia
authors.initials: E
authors.lastname: Gatto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008538:Meige Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D009465:Neuromuscular Agents / Q000627:therapeutic use; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A