Natural killer lymphoma/leukemia: an uncommon pediatric case with indolent course.
Natural killer (NK) cell lymphomas are rare in the USA and Europe but more common in Asia and Central America although very rare among children. We report a case of Epstein-Barr virus-positive NK lymphoma/leukemia, that showed peculiar features represented by a very long clinical course with a significant interval between the first clinical signs and the diagnosis, detection of neoplastic cells in the peripheral blood but not in the bone marrow, and good response to treatment and clinical outcome.
Di Cataldo
Andrea
A
Centre of Paediatric Haematology and Oncology, University of Catania, Via Santa Sofia, 78, 95123 Catania, Italy. adicata@unict.it
Bertuna
Gregoria
G
Mirabile
Elena
E
Munda
Silvana
S
Tettoni
Katia
K
Notarangelo
Luigi D
LD
Facchetti
Fabio
F
Lo Nigro
Luca
L
D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology / Q000821:virology; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology* / Q000821:virology; D007938:Leukemia / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D016896:Treatment Outcome; D014747:Vinblastine / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D004279:DNA, Viral; D014747:Vinblastine