title: Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion.
abstract: Autoantibodies may cause severe hemolytic anemia, but only rarely are they the cause of a hemolytic transfusion reaction due to the destruction of transfused allogeneic blood. In two patients, autoantibody was detected shortly after blood transfusion. The first case was a D-negative patient who produced an autoanti-Ce and subsequently developed hemoglobinuria and hyperbilirubinemia. The second case was a patient who developed an autoanti-Wrb that caused severe hemolysis that resulted in death.
authors.affiliation: National Blood Service, South West, Southmead Road, Bristol BS10 5ND, UK.
authors.forename: D
authors.initials: D
authors.lastname: Chan
authors.forename: G D
authors.initials: GD
authors.lastname: Poole
authors.forename: M
authors.initials: M
authors.lastname: Binney
authors.forename: M D
authors.initials: MD
authors.lastname: Hamon
authors.forename: J A
authors.initials: JA
authors.lastname: Copplestone
authors.forename: A G
authors.initials: AG
authors.lastname: Prentice