title: Palladium-catalyzed cross-coupling of aryl electrophiles with dimethylalkynylaluminum reagents.
abstract: [reaction: see text] Alkynyldimethylaluminum reagents are easily available from terminal alkynes and trimethylaluminum via a triethylamine-catalyzed metalation. These compounds can react with various aromatic and heterocyclic halides in the presence of palladium in a fast and efficient way. This catalyzed cross-coupling reaction provides a simple entry to numerous internal alkynes, using a readily available, inexpensive, and nontoxic metalating agent.
authors.affiliation: Laboratoire de Chimie Thérapeutique, UMR 8638 associée au CNRS et à l'Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 av de l'Observatoire, 75270 Paris Cedex 06, France.
authors.forename: Baomin
authors.initials: B
authors.lastname: Wang
authors.forename: Martine
authors.initials: M
authors.lastname: Bonin
authors.forename: Laurent
authors.initials: L
authors.lastname: Micouin