Mechanisms of cardiovascular protection by resveratrol.
The phytoantitoxin resveratrol is a plant-derived polyphenol with phytoestrogenic properties. Resveratrol protects the cardiovascular system by mechanisms that include defense against ischemic-reperfusion injury, promotion of vasorelaxation, protection and maintenance of intact endothelium, anti-atherosclerotic properties, inhibition of low-density lipoprotein oxidation, suppression of platelet aggregation, and estrogen-like actions. The purpose of this article is to review the mechanisms of these effects.
Hao
Han Dong
HD
Postgraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
He
Li Ren
LR
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D048789:Phytoestrogens / Q000627:therapeutic use; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D002317:Cardiovascular Agents; D048789:Phytoestrogens; D013267:Stilbenes; D000077185:Resveratrol