title: Characterization of karyotypic events and evolution in neuroblastoma.
abstract: BACKGROUND
  Neuroblastoma (NB) is cytogenetically characterized by a number of non-random events. However, knowledge is limited concerning the timing of occurrence and inter-action of many of these events.
  
  
  METHODS
  Karyotypic patterns were obtained from a study group of 49 NB tumors that had been analyzed by conventional cytogenetics combined with FISH and in some instances SKY.
  
  
  RESULTS
  All chromosomes were involved in a numerical and structural aberration in at least one tumor. There was a positive correlation between the occurrence of MYCN and del(1p) and between del(1p) and 17q. Aberrations involving chromosomes X, 3, 19, and del(1p) could be considered early events, whereas those involving chromosomes 9, 13, 15, 18, 20, and 21 were often late events.
  
  
  CONCLUSIONS
  This study suggests that the karyotypic patterns characterizing NB are complex. There are aberrations that can be grouped into early or late karyotypic events, but others, such as gain of 17q, are variable.
authors.affiliation: Department of Oncology, University Children's Hospital, Zürich, Switzerland. david.betts@kispi.unizh.ch
authors.forename: David R
authors.initials: DR
authors.lastname: Betts
authors.forename: Ninette
authors.initials: N
authors.lastname: Cohen
authors.forename: Kurt E
authors.initials: KE
authors.lastname: Leibundgut
authors.forename: Thomas
authors.initials: T
authors.lastname: Kühne
authors.forename: Ueli
authors.initials: U
authors.lastname: Caflisch
authors.forename: Jeanette
authors.initials: J
authors.lastname: Greiner
authors.forename: Luba
authors.initials: L
authors.lastname: Traktenbrot
authors.forename: Felix K
authors.initials: FK
authors.lastname: Niggli
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D000071447:N-Myc Proto-Oncogene Protein; D009447:Neuroblastoma / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics
chemical_list: C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins