title: Involvement of immunoglobulin FcgammaRIIA and FcgammaRIIIB gene polymorphisms in susceptibility to rheumatic fever.
abstract: OBJECTIVE
  To assess the impact of the human FcgammaRIIA and FcgammaRIIIB gene polymorphisms on the risk of rheumatic fever (RF).
  
  
  METHODS
  FcgammaRIIA-R/H-131 and FcgammaRIIIB-NA1/NA2 genotypes were determined using polymerase chain reaction in 66 RF cases and 117 healthy controls in this case control study.
  
  
  RESULTS
  Compared with healthy controls, the RR genotype was enriched in the entire group of RF cases (odds ratio [OR] 4.98, 95% confidence interval [95% CI] 1.81-13.70). RF patients were more frequently HR heterozygotes rather than HH homozygotes (OR 3.09 vs. 0.11). The results of this study show that patients who have RF are more likely to have the RR and HR genotypes than control children. These probabilities show that RR is associated with the greatest risk for rheumatic fever and HR is associated with an intermediate risk. For the distribution of FcgammaRIIIB NA2 genotypes, a nonsignificant increase was found in RF patients (39.31% vs. 51.51%; OR 1.64, P = 0.1226).
  
  
  CONCLUSIONS
  The FcgammaRIIA-R/H-131 polymorphism may be an important marker in determining predisposition to RF.
authors.affiliation: Laboratory of Molecular Medicine, Department of Pediatrics, Ege University School of Medicine, Bornova, 35100 Izmir, Turkey. afig@med.ege.edu.tr
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
authors.forename: Handan Ak
authors.initials: HA
authors.lastname: Celik
authors.forename: Ruhi
authors.initials: R
authors.lastname: Ozyürek
authors.forename: Hikmet Hakan
authors.initials: HH
authors.lastname: Aydin
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D058851:GPI-Linked Proteins; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012213:Rheumatic Fever / Q000235:genetics* / Q000276:immunology; D014421:Turkey
chemical_list: D015703:Antigens, CD; C428200:FCGR3B protein, human; C080568:Fc gamma receptor IIA; D058851:GPI-Linked Proteins; D017452:Receptors, IgG