Effects of the active neurosteroid allotetrahydrodeoxycorticosterone on long-term potentiation in the rat hippocampus: implications for depression.
We studied the effects of the active neurosteroid (ANS) allotetrahydrodeoxy corticosterone (ATHDOC) on long-term potentiation (LTP) in the dentate gyrus (DG) of intact, urethane anesthetized rats. Intravenous injection of the hormone at two doses, 0.1 and 0.5 mg/kg, produced a significant decrease in both components of the response: excitatory postsynaptic potentials (EPSP) and population spikes (PS). The effects were similar for the two doses. The results are discussed in terms of the potential mechanism by which ATHDOC modulates neural processes associated with symptoms present in depression syndromes.
Dubrovsky
Bernardo
B
McGill University Health Center, 3445 Drummond Street, #701, Montreal, Quebec, H3G 1X9, Canada. bdubro@po-box.mcgill.ca
Tatarinov-Levin
Anna
A
Harris
John
J
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D014151:Anti-Anxiety Agents; D003900:Desoxycorticosterone; C009413:tetrahydrodeoxycorticosterone