Fluorescent bronchoscopy.
Detection of clinically occult lung neoplasms may represent an opportunity for early curative intervention. Fluorescent bronchoscopy is a sensitive technique for detecting early endobronchial tumors that may be combined with CT scanning as part of a comprehensive lung cancer screening program. Identification and longitudinal follow-up of dysplastic endobronchial changes with fluorescent bronchoscopy should facilitate studies of chemoprevention and further knowledge regarding the natural history of these lesions. Analysis of bronchial epithelium with novel techniques such as genomic hybridization and gene expression arrays might provide even better predictors of progression of dysplastic endobronchial lesions.
Gilbert
Sebastien
S
Division of Thoracic and Foregut Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite C800, Pittsburgh, PA 15213, USA.
Luketich
James D
JD
Christie
Neil A
NA
D001984:Bronchial Neoplasms / Q000175:diagnosis / Q000473:pathology*; D001999:Bronchoscopy / Q000379:methods*; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology; D002986:Clinical Trials as Topic; D005260:Female; D005453:Fluorescence; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D012680:Sensitivity and Specificity