Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge.
Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection. A combination of these two proteins administered orally conferred improved protection compared to that conferred by either protein administered alone.
Wang
Lina
L
Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Goschnick
Matthew W
MW
Coppel
Ross L
RL
D000284:Administration, Oral; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis / Q000276:immunology; D000953:Antigens, Protozoan / Q000235:genetics / Q000276:immunology*; D004359:Drug Therapy, Combination; D004926:Escherichia coli / Q000235:genetics; D007132:Immunoglobulin Isotypes / Q000032:analysis / Q000276:immunology; D008288:Malaria / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D017780:Malaria Vaccines / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D020066:Merozoite Surface Protein 1 / Q000235:genetics / Q000276:immunology*; D051379:Mice; D018512:Parasitemia / Q000097:blood / Q000276:immunology; D010967:Plasmodium yoelii / Q000235:genetics / Q000276:immunology*; D015800:Protozoan Proteins / Q000235:genetics / Q000276:immunology*; D015996:Survival Rate
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D007132:Immunoglobulin Isotypes; D017780:Malaria Vaccines; D008565:Membrane Proteins; D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; C118839:merozoite surface protein 4, Plasmodium; C114957:merozoite surface protein 5