Use of deoxyribose by intestinal and extraintestinal pathogenic Escherichia coli strains: a metabolic adaptation involved in competitiveness.
We showed that the deoK operon, which confers the ability to use deoxyribose as a carbon source, is more common among pathogenic than commensal Escherichia coli strains. The expression of the deoK operon increases the competitiveness of clinical isolates, suggesting that this biochemical characteristic plays a role in host infectivity.
Bernier-Fébreau
Christine
C
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France.
du Merle
Laurence
L
Turlin
Evelyne
E
Labas
Valérie
V
Ordonez
Juana
J
Gilles
Anne-Marie
AM
Le Bouguénec
Chantal
C
D017124:Conserved Sequence; D003855:Deoxyribose / Q000378:metabolism*; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008969:Molecular Sequence Data; D009876:Operon / Q000235:genetics*
D029968:Escherichia coli Proteins; D003855:Deoxyribose