Interferon alpha (IFN) treatment of bone marrow stroma inhibits haematopoesis.
Prolonged pre-transplant IFN administration in patients with chronic myeloid leukaemia has been associated with an increased risk of fatal transplant-related complications and an inferior outcome after allogeneic bone marrow transplantation. Using a two-stage long-term bone marrow culture as an in vitro model we were able to show a negative effect of higher doses of IFN pre-treatment of bone marrow stroma on haematopoesis. This correlated with a decline in the number of monocytes-macrophages. While monocytes-macrophages itself produce cytokines, a vicious circle may lead to an ineffective function of the microenvironment resulting in ineffective haematopoieses and increased transplant-related complications.
Kasper
Christoph
C
Department of Medicine IV (Haematology and Oncology), Martin-Luther-University, Halle-Wittenberg, Ernst-Grube-Street 40, Halle (Saale) D-06120, Germany. christoph.kasper@web.de
Lübking
Anna
A
Beelen
Dietrich W
DW
Dührsen
Ullrich
U
D001853:Bone Marrow / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D017154:Stromal Cells / Q000187:drug effects*
D016898:Interferon-alpha