title: Noninvasive assessment of bladder contractility in men.
abstract: OBJECTIVE
  Preoperative assessment of detrusor function by pressure flow study (PFS) improves outcome from prostatectomy but is invasive and uncomfortable for the patient. We report on a large scale validation of a novel noninvasive assessment of detrusor contractility.
  
  
  METHODS
  A flexible cuff placed around the penis was inflated automatically during voiding until flow interruption. Cuff pressure at interruption (pcuff.int) reflects isovolumetric bladder pressure (pves.isv), a measure of detrusor contractility. For comparison 151 symptomatic men performed the cuff test with simultaneous PFS monitoring. Test/retest agreement was assessed in 91 subjects who performed a cuff test without PFS on 2 occasions.
  
  
  RESULTS
  For the 117 (77%) subjects with an acceptable cuff pressure flow trace, Bland Altman analysis showed that pcuff.int overestimated pves.isv by a mean (s.d.) of 16.4 (27.5) cm H2O, predominantly due to the cuff being positioned below the bladder. For test/retest analysis 52 (57%) of the men who were able to attend twice provided acceptable cuff data on both occasions with a mean (s.d.) difference in pcuff.int of -3.3 (32.0) cm H2O, improving to 0.0 (20.3) cm H2O in a subgroup of 39 subjects who voided more than 150 ml. On questionnaire assessment 121 (80%) subjects preferred the cuff test to PFS.
  
  
  CONCLUSIONS
  The cuff test gives a valid and reproducible estimate of isovolumetric bladder pressure in a manner acceptable to patients, although test failure and variability of agreement require improvement. The test may be of value in the assessment of urinary symptoms and may aid in patient selection for prostatectomy.
authors.affiliation: Department of Urology, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
authors.forename: Stuart L
authors.initials: SL
authors.lastname: McIntosh
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Drinnan
authors.forename: Clive J
authors.initials: CJ
authors.lastname: Griffiths
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Robson
authors.forename: Peter D
authors.initials: PD
authors.lastname: Ramsden
authors.forename: Robert S
authors.initials: RS
authors.lastname: Pickard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001795:Blood Pressure Determination / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D008297:Male; D008365:Manometry / Q000295:instrumentation; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000175:diagnosis* / Q000503:physiopathology; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D001743:Urinary Bladder / Q000503:physiopathology*; D001748:Urinary Bladder Neck Obstruction / Q000175:diagnosis* / Q000503:physiopathology; D014546:Urinary Catheterization / Q000295:instrumentation; D014563:Urodynamics / Q000502:physiology*