[HIV and brain].
The prevalence of HIV encephalopathy in the era of HAART ist about 10%. HAART, which should contain drugs that penetrate into the CNS, can relieve symptoms or delay manifestation and progress of the disease. Depressive disorders are often not diagnosed, their prevalence is 16-37%. Thorough antidepressive treatment improves quality of life and general health. Pain syndromes occur in 30-60%, are also often underdiagnosed and should be treated. While choosing antidepressants and drugs against pain, attention must be paid on interactions with HAART via the cytochrome P450 system.
Schielke
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Klinik für Neurologie, Vivantes Auguste-Viktoria-Klinikum, Berlin. eva.schielke@vivantes.de
D015526:AIDS Dementia Complex / Q000188:drug therapy* / Q000523:psychology*; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D018697:Nootropic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D010146:Pain / Q000188:drug therapy* / Q000523:psychology*
D000700:Analgesics; D019380:Anti-HIV Agents; D000928:Antidepressive Agents; D018697:Nootropic Agents
Das Spektrum neurologischer und psychiatrischer Komplikationen von HIV. Depression-Schmerzen-Enzephalopathie.