Usefulness of brain natriuretic peptide levels to discriminate patients with stable angina pectoris without and with electrocardiographic myocardial ischemia and patients with healed myocardial infarction.
Brain natriuretic peptide (BNP) levels were measured in 100 patients with coronary heart disease (CHD) who underwent myocardial stress thallium-201 single-photon emission computed tomography (30 with stable angina without basal electrocardiographic ischemia and no perfusion defects, 31 with angina with electrocardiographic ischemia and reversible perfusion defects, and 39 with myocardial infarction and irreversible defects) and in 42 controls. BNP levels progressively increased in patients with CHD and were significantly greater in patients with ischemia (p <0.01) and infarction (p <0.001) compared with controls and subjects with angina. BNP concentration was correlated positively (r = 0.923, p <0.001) with perfusion defect extent and inversely (r = -0.690, p <0.001) with the left ventricle ejection fraction (not different in the subjects examined).
Palumbo
Barbara
B
Department of Radiological Science, Section of Nuclear Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti, 06124 Perugia, Italy. nednuc@unipg.it
Siepi
Donatella
D
Lupattelli
Graziana
G
Sinzinger
Helmut
H
Fiorucci
Giuliana
G
Anniboletti
Pier Fabrizio
PF
Latini
Roberto A
RA
Mannarino
Elmo
E
Palumbo
Renato
R
D000704:Analysis of Variance; D000787:Angina Pectoris / Q000097:blood* / Q000000981:diagnostic imaging; D004562:Electrocardiography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging; D017202:Myocardial Ischemia / Q000097:blood* / Q000000981:diagnostic imaging; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D013794:Thallium Radioisotopes; D020097:Natriuretic Peptide, Brain