title: Pigmented astrocytoma with suprasellar location: case report and literature review.
abstract: A large suprasellar, partly cystic, contrast-enhancing tumor was resected from a 19-year-old woman who presented with bitemporal visual field defects and reduced visual acuity. Grossly, the tumor was brown and located in the subarachnoid space. Histologically, it was composed of spindle and pleomorphic cells, including giant tumor cells, with markedly pleomorphic nuclei. Reticulin fibers surrounded single cells and small groups of cells. Very few mitotic figures were found in the tumor, and no necrosis or microvascular proliferation was seen. The tumor thereby resembled a pleomorphic xanthoastrocytoma. Many of the tumor cells contained a dark-brown intracytoplasmic pigment, shown to be melanosomal melanin by ultrastructural examination. Immunohistochemical examination demonstrated that the pigment was present in glial tumor cells. Only four cases of pigmented astrocytic tumors have been published, none of these were suprasellar. Our patient received fractionated radiotherapy with a total dose of 48.6 Gy 14 months after gross total removal of the tumor. She is alive without relapse after 12-year follow-up.
authors.affiliation: The Gade Institute, Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway. bkkr@haukeland.no
authors.forename: Bård Kronen
authors.initials: BK
authors.lastname: Krossnes
authors.forename: Olav
authors.initials: O
authors.lastname: Mella
authors.forename: Knut
authors.initials: K
authors.lastname: Wester
authors.forename: Sverre Jarl
authors.initials: SJ
authors.lastname: Mørk
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008544:Melanocytes; D046529:Microscopy, Electron, Transmission