Hypoxia simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor production by cultured human endometrial stromal cells.
Hypoxia downregulated the concentration of endostatin in the culture media of human endometrial stromal cells but did not affect the messenger (m)RNA expression of collagen XVIII. Both mRNA and protein expression of vascular endothelial growth factor were upregulated in a hypoxic condition.
Nasu
Kaei
K
Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama-machi, Oita 879-5593, Japan. nasu@med.oita-u.ac.jp
Nishida
Masakazu
M
Fukuda
Junichiro
J
Kawano
Yasushi
Y
Nishida
Yoshihiro
Y
Miyakawa
Isao
I
D000328:Adult; D015687:Cell Hypoxia / Q000502:physiology*; D002478:Cells, Cultured; D004717:Endometrium / Q000473:pathology*; D043169:Endostatins / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D017697:Premenopause; D012333:RNA, Messenger / Q000235:genetics; D017154:Stromal Cells / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
D043169:Endostatins; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A