Plasma homocysteine levels after hormone therapy with and without folic acid supplementation: a randomized study.
Sequential transdermal estrogen-progestin therapy induced a significant reduction in fasting serum homocysteine levels in postmenopausal women. The addition of folic acid supplementation for 6 months did not further lower the homocysteine concentrations.
Ghezzi
Fabio
F
Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Piazza Biroldi 1, 21100 Varese, Italy. fabio.ghezzi@uninsubria.it
Buttarelli
Marco
M
Cromi
Antonella
A
Raio
Luigi
L
Cedars
Marcelle
M
Bolis
Pierfrancesco
P
D000328:Adult; D019587:Dietary Supplements; D004958:Estradiol / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology*
D006710:Homocysteine; D004958:Estradiol; D005492:Folic Acid