title: [P. aeruginosa bacteremias: analysis of prognostic factors. A prospective study, 1992-1998].
abstract: BACKGROUND
  P. aeruginosa causes serious infections with high mortality.
  
  
  OBJECTIVE
  Identify the prognostic factors associated with higher mortality in P. aeruginosa bacteremias (PAB).
  
  
  METHODS
  211 consecutive cases of PAB were analyzed prospectively between 1992-1998. Blood cultures, isolation, and antimicrobial sensitivity were carried out according to microbiology standard methodology. The variables analyzed as prognostic factors were: sex, age, source of infection, background, main disease, initial clinical severity, foci, presence of complications, leukocyte count, type of antibiotic treatment and adaptation. Bivariate and multivariate statistical analyses were carried out by the method of logistic regression.
  
  
  RESULTS
  Global mortality was 27.96%; factors associated with higher mortality in the bivariate study were main disease rapidly and eventually fatal, diabetes, a situation of critical initial clinical severity, lung focus, complications, neutropenia and inadequate antibiotic treatment. The logistic regression study, the critical initial clinical severity, and the presence of complications were the variables associated with worse prognosis. We did not find significant differences in the evolution among the patients who received monotherapy and those on combinations of antimicrobial drugs against pseudomonas.
  
  
  CONCLUSIONS
  Higher mortality of PAB is statistically associated to the situation of critical initial clinical severity and to the presence of complications; therefore, an early diagnosis and adequate treatment to improve the morbidity and mortality are recommended.
authors.affiliation: Servicios de Medicina Interna y Enfermedades Infecciosas, Hospital Universitario Virgen de la Arrixaca.
authors.forename: J
authors.initials: J
authors.lastname: Gómez Gómez
authors.forename: M
authors.initials: M
authors.lastname: Alcántara Villar
authors.forename: E
authors.initials: E
authors.lastname: Simarro Córdoba
authors.forename: B
authors.initials: B
authors.lastname: Martínez Vicente
authors.forename: J
authors.initials: J
authors.lastname: Ruiz Gómez
authors.forename: B
authors.initials: B
authors.lastname: Guerra Pérez
authors.forename: J A
authors.initials: JA
authors.lastname: Herrero Martínez
authors.forename: M
authors.initials: M
authors.lastname: Canteras Jordana
authors.forename: M
authors.initials: M
authors.lastname: Valdés Chavarri
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Bacteriemias por P. aeruginosa: análisis de los factores pronóstico. Estudio prospectivo 1992-1998.