Development of Parkinson's disease in patients with blepharospasm.
The liability to develop parkinsonian symptoms was evaluated in 105 outpatients with idiopathic blepharospasm (IBS; 54 cases) or IBS associated to oromandibular dystonia (Meige's syndrome; 51 cases) mean age 70.3 +/- 9.6 years, and compared with an age- and sex-matched population. Eleven patients developed Parkinson's disease in the blepharospasm group, whereas only 2 of 105 patients were affected in the control group. Our results suggest that patients with IBS either isolated or associated with oromandibular dystonia are more prone to develop parkinsonian symptoms.
Micheli
Federico
F
Programa de Parkinson y Movimientos Anormales, Instituto de Neurociencias, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina. fmicheli@fibertel.com.ar
Scorticati
María Clara
MC
Folgar
Silvia
S
Gatto
Emilia
E
D000368:Aged; D000369:Aged, 80 and over; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008538:Meige Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D009465:Neuromuscular Agents / Q000627:therapeutic use; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A