Non-genomic effects of aldosterone: new actions and questions.
Although the classical actions of aldosterone are mediated through genomic pathways, there is a growing recognition of important nongenomic responses to aldosterone. New data are presented from two laboratories showing a nongenomic effect of aldosterone to activate protein kinase C (PKC) in heart and kidney. Among the actions of PKC is the stimulation of transcription factors, raising the question of whether there is an inter-relationship of nongenomic with genomic influences--aldosterone induced nongenomic effects might modulate genomic effects. This expanded role of aldosterone will require exploration in future studies.
Chun
Tae-Yon
TY
Department of Medicine, Indiana University School of Medicine and the Richard L. Roudebush VA Medical Center 151, Indianapolis IN46102, USA.
Pratt
J Howard
JH
D000450:Aldosterone / Q000502:physiology*; D000818:Animals; D004789:Enzyme Activation / Q000502:physiology; D016678:Genome; D006801:Humans; D007668:Kidney / Q000201:enzymology / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors; D000450:Aldosterone; D011493:Protein Kinase C