5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.
5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.
Sulsky
Richard
R
Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. sulskyr@bms.com
Robl
Jeffrey A
JA
Biller
Scott A
SA
Harrity
Thomas W
TW
Wetterau
John
J
Connolly
Fergal
F
Jolibois
Kern
K
Kunselman
Lori
L
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D006224:Cricetinae; D003498:Cyclic P-Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000577:Amides; C473731:BMS201038; D001562:Benzimidazoles; D002352:Carrier Proteins; D003498:Cyclic P-Oxides; C106092:microsomal triglyceride transfer protein