TNF signalling in tooth development.
Mammalian tooth development has served as an excellent model system to investigate the intricate, interactive mechanisms of patterning, morphogenesis and cytodifferentiation during organogenesis. Teeth develop from interactions between epithelium and neural crest-derived (ecto)mesenchyme that are largely mediated by ligand-receptor signalling. It is well-established that signalling molecules of the Bmp, Fgf, Wnt and Hedgehog families, are involved at multiple stages of tooth development. Recently, however, a specific role for molecules belonging to the TNF-family of ligands in tooth morphogenesis has been identified, suggesting that this pathway, acting to activate NF-kappaB, has played an important role in the development and evolution of tooth number and shape.
Ohazama
Atsushi
A
Department of Craniofacial Development, Dental Institute, King's College, Guy's Hospital, London Bridge, London SE1 9RT, UK.
Sharpe
Paul T
PT
D000818:Animals; D001842:Bone and Bones / Q000196:embryology / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D015398:Signal Transduction; D014070:Tooth / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D048069:Tumor Necrosis Factors / Q000378:metabolism*
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C505688:TNFSF11 protein, human; D048069:Tumor Necrosis Factors