title: Most effective stimulation site in subthalamic deep brain stimulation for Parkinson's disease.
abstract: The optimal stimulation site in subthalamic deep brain stimulation (STN-DBS) was evaluated by correlation of the stereotactic position of the stimulation electrode with the electrophysiologically specified dorsal STN border. In a series of 25 electrodes, best clinical results with least energy consumption were found in contacts located in the dorsolateral border zone, whereas contacts within the subthalamic white matter, e.g., zona incerta, were significantly less effective. We suggest that the dorsolateral STN border should be covered by STN-DBS.
authors.affiliation: Department of Neurology, Christian-Albrechts-Universität Kiel, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Herzog
authors.forename: Urban
authors.initials: U
authors.lastname: Fietzek
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hamel
authors.forename: Andre
authors.initials: A
authors.lastname: Morsnowski
authors.forename: Frank
authors.initials: F
authors.lastname: Steigerwald
authors.forename: Bettina
authors.initials: B
authors.lastname: Schrader
authors.forename: Dieter
authors.initials: D
authors.lastname: Weinert
authors.forename: Gerd
authors.initials: G
authors.lastname: Pfister
authors.forename: Dieter
authors.initials: D
authors.lastname: Müller
authors.forename: Hubertus M
authors.initials: HM
authors.lastname: Mehdorn
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
authors.forename: Jens
authors.initials: J
authors.lastname: Volkmann
mesh_terms: D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004567:Electrodes, Implanted; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D013378:Substantia Nigra / Q000473:pathology; D020531:Subthalamic Nucleus / Q000473:pathology / Q000502:physiology*