title: Cancer evolution and immunity in a rat colorectal carcinogenesis model.
abstract: Tumor development is modulated by the interplay between the transformed cells and the host, and produces changes in the immune system. We followed the cancer progression and the variation of immune parameters in a rat in vivo model of induced colorectal carcinoma. Retrospective data collected from different experiments illustrated the dynamics of the tumor development, and of the immune cells (NK, NKT, T, CD4+, CTL, B and gammadeltaTCR+ cells), cytotoxicity, and CD4/CD8 ratio, at the third, sixth and eighth month of carcinogenesis. The chemically-induced carcinogenesis involved the complete large bowel, with progressive generation of multiple tumors during the complete considered period. Reduction in number and function of cytotoxic and regulatory cells of the innate immunity were crucial for cancer progression.
authors.affiliation: Laboratory of Natural Cell Immunity, Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 14220 Prague 4, Czech Republic. vannucci@biomed.cas.cz
authors.forename: Luca
authors.initials: L
authors.lastname: Vannucci
authors.forename: Anna
authors.initials: A
authors.lastname: Fiserova
authors.forename: Ondrej
authors.initials: O
authors.lastname: Horvath
authors.forename: Pavel
authors.initials: P
authors.lastname: Rossmann
authors.forename: Franco
authors.initials: F
authors.lastname: Mosca
authors.forename: Miloslav
authors.initials: M
authors.lastname: Pospisil
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D003602:Cytotoxicity, Immunologic; D004195:Disease Models, Animal; D007109:Immunity; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta