Very efficient phosphoramidite ligand for asymmetric iridium-catalyzed allylic alkylation.
[reaction: see text] Linear or branched allylic carbonates or acetates undergo enantioselective iridium-catalyzed allylic substitution with sodium malonate. The reaction is wide in scope and affords the branched product in high yield and with high regio- (up to >99:1) and enantioselectivity (up to 98%). Ten aromatic or aliphatic substrates were successfully tested.
Alexakis
Alexandre
A
Department of Organic Chemistry, University of Geneva, 30, quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland. alexandre.alexakis@chiorg.unige.ch
Polet
Damien
D