New decalin derivatives, eujavanoic acids A and B, from Eupenicillium javanicum.
Two new decalin derivatives, eujavanoic acids A (1) and B (2), were isolated from Eupenicillium javanicum, along with several compactin derivatives. The structures of 1 and 2 were determined by spectroscopic methods and modified Mosher's method. The side chain (2-methylbutanoyloxy) and acid functionalities of compactin derivatives were necessary to show the antifungal activity.
Okamoto
Shigeru
S
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Hosoe
Tomoo
T
Itabashi
Takeshi
T
Nozawa
Koohei
K
Okada
Kaoru
K
Takaki
Galba Maria de Campos
GM
Chikamori
Minoru
M
Yaguchi
Takashi
T
Fukushima
Kazutaka
K
Miyaji
Makoto
M
Kawai
Ken-Ichi
K
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D009281:Naphthalenes; C493124:eujavanoic acid A; C493123:eujavanoic acid B; C012258:mevastatin; C007229:decalin; D008148:Lovastatin