title: New indole alkaloids from the bark of Alstonia scholaris.
abstract: A new indole alkaloid, akuammiginone (1), and a new glycosidic indole alkaloid, echitamidine-N-oxide 19-O-beta-d-glucopyranoside (2), together with the five known alkaloids, echitaminic acid (3), echitamidine N-oxide (4), N(b)-demethylalstogustine N-oxide (5), akuammicine N-oxide (6), and N(b)-demethylalstogustine (7), were isolated from the trunk bark of Alstonia scholaris collected in Timor, Indonesia. The structures of all compounds were elucidated by spectroscopic methods. This is the first report of compounds 3-5and 7 in A. scholaris. Some NMR assignments of the known compounds were revised.
authors.affiliation: Institute for Molecular Bioscience and Department of Chemistry, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Angela A
authors.initials: AA
authors.lastname: Salim
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Garson
authors.forename: David J
authors.initials: DJ
authors.lastname: Craik
mesh_terms: D031051:Alstonia / Q000737:chemistry*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D026121:Indole Alkaloids; C492808:akuammiginone