Novel [2 + 2 + 2 + 1] cycloaddition of enediynes catalyzed by rhodium complexes.
[reaction: see text] The first Rh-catalyzed intramolecular [2 + 2 + 2 + 1] cycloaddition reaction of enediynes and CO is reported. This novel higher order cycloaddition process gives the corresponding 5-7-5 ring systems in high yield and selectivity. This process is another significant addition to the arsenal of cycloaddition-based synthetic methods, which provide powerful tools for rapid and efficient construction of complex polycyclic systems.
Bennacer
Bibia
B
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA.
Fujiwara
Masaki
M
Ojima
Iwao
I
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis*; D012238:Rhodium / Q000737:chemistry*
D000480:Alkynes; D011084:Polycyclic Aromatic Hydrocarbons; D012238:Rhodium