title: New diterpenoids from the marine mangrove Bruguiera gymnorrhiza.
abstract: Phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded three new ent-kaurane diterpenoids (1, 2, and 3) and one new ent-beyerane diterpenoid (4) together with nine known ent-kaurane diterpenoids. All structures and the relative stereochemistry of the new compounds were determined by NMR spectroscopic studies. The absolute stereochemistry of 4 was determined by CD data. Some of the compounds showed moderate cytotoxic properties.
authors.affiliation: National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
authors.forename: Isabel
authors.initials: I
authors.lastname: Sattler
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Dahse
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Fu
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Susanne
authors.initials: S
authors.lastname: Grabley
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D002942:Circular Dichroism; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D043982:Rhizophoraceae / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane