title: Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group.
authors.affiliation: Laboratorium für Organische Chemie, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
authors.forename: Ralph
authors.initials: R
authors.lastname: Paulini
authors.forename: Christian
authors.initials: C
authors.lastname: Lerner
authors.forename: Roland
authors.initials: R
authors.lastname: Jakob-Roetne
authors.forename: Gerhard
authors.initials: G
authors.lastname: Zürcher
authors.forename: Edilio
authors.initials: E
authors.lastname: Borroni
authors.forename: François
authors.initials: F
authors.lastname: Diederich
mesh_terms: D002394:Catechol O-Methyltransferase / Q000737:chemistry; D065098:Catechol O-Methyltransferase Inhibitors; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007202:Indicators and Reagents; D008274:Magnesium / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009574:Nitro Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D065098:Catechol O-Methyltransferase Inhibitors; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D009574:Nitro Compounds; D002394:Catechol O-Methyltransferase; D008274:Magnesium