title: [Sirolimus-eluting stents for the treatment of symptomatic extracranial vertebral artery stenoses: early experience and 6-month follow-up].
abstract: OBJECTIVE
  To evaluate the clinical and morphological effectiveness of sirolimus-eluting stents in patients with stenoses in the extracranial vertebral artery and to assess the 6-month results.
  
  
  METHODS
  Sirolimus-eluting stents were implanted in 8 stenoses of the extracranial vertebral artery in 7 patients with symptoms of vertebrobasilar insufficiency. Seven stenoses were located at the ostium, and one further cranially in segment V 1. The mean grade diameter of the stenoses was 85.1 % (60.9 % - 98.3 %). Clinical and angiographic follow-up was performed over a period of 6 months in all patients.
  
  
  RESULTS
  All lesions were successfully stented with a residual stenosis of 20.2 % (0.0 - 38.5 %). Clinically, all patients showed resolution or improvement of the symptoms after stenting. After 6 months, 5 of the 8 stenoses developed intimal hyperplasia with a stenosis grade > 50 %. The mean measured grade of stenosis after 6 months was 56.2 % (0.0 - 94.1 %). Five patients had no clinical symptoms of a vertebrobasilar insufficiency while two had recurrent symptoms.
  
  
  CONCLUSIONS
  Sirolimus-eluting stents in the extracranial vertebral artery have a high and unsatisfactory re-stenosis rate after 6 months.
authors.affiliation: Institut für Radiologie, Krankenhaus Wels. herbert.lugmayr@khwels.at
authors.forename: H
authors.initials: H
authors.lastname: Lugmayr
authors.forename: M
authors.initials: M
authors.lastname: Kastner
authors.forename: W
authors.initials: W
authors.lastname: Fröhler
authors.forename: S
authors.initials: S
authors.lastname: Meindl
authors.forename: R
authors.initials: R
authors.lastname: Zisch
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents; D013997:Time Factors; D014711:Vertebral Artery; D014715:Vertebrobasilar Insufficiency / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D020123:Sirolimus
vernacular_title: Die Behandlung symptomatischer extrakranieller Stenosen der Arteria vertebralis mit sirolimusbeschichteten Stents: erste Erfahrungen und Ergebnisse nach 6 Monaten.