Therapeutic potential of yeast killer toxin-like antibodies and mimotopes.
This review focuses on the potential of yeast killer toxin (KT)-like antibodies (KTAbs), that mimic a wide-spectrum KT through interaction with specific cell wall receptors (KTR) and their molecular derivatives (killer mimotopes), as putative new tools for transdisease anti-infective therapy. KTAbs are produced during the course of experimental and natural infections caused by KTR-bearing micro-organisms. They have been produced by idiotypic vaccination with a KT-neutralizing mAb, also in their monoclonal and recombinant formats. KTAbs and KTAbs-derived mimotopes may exert a strong therapeutic activity against mucosal and systemic infections caused by eukaryotic and prokaryotic pathogenic agents, thus representing new potential wide-spectrum antibiotics.
Magliani
Walter
W
Sezione di Microbiologia, Dipartimento di Patologia e Medicina di Laboratorio, Università degli Studi di Parma, Viale Antonio Gramsci 14, 43100 Parma, Italy. magliwal@unipr.it
Conti
Stefania
S
Salati
Antonella
A
Vaccari
Simona
S
Ravanetti
Lara
L
Maffei
Domenico L
DL
Polonelli
Luciano
L
D000595:Amino Acid Sequence; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology / Q000627:therapeutic use; D000908:Antibodies, Fungal / Q000276:immunology* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive / Q000379:methods; D055646:Killer Factors, Yeast; D018716:Molecular Mimicry / Q000276:immunology*; D008969:Molecular Sequence Data; D009183:Mycotoxins / Q000276:immunology*; D010843:Pichia / Q000276:immunology*; D014611:Vaccination / Q000379:methods
D000888:Antibodies, Anti-Idiotypic; D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D055646:Killer Factors, Yeast; D009183:Mycotoxins; C087906:killer toxin, Pichia