A comparison of SepPak and high-performance liquid chromatography as techniques for measuring the radiochemical purity of 99mTc-MAG3.
OBJECTIVE
To compare high-performance liquid chromatography and SepPak as techniques for measuring the radiochemical purity of 99mTc-MAG3.


METHODS
Samples of 99mTc-MAG3 (n = 20) with radiochemical purities in the range 43-98% were prepared and analysed by both techniques.


RESULTS
The correlation between the results from the two techniques was excellent (r = 1.00) and the differences between the results were not statistically significant (P > 0.05).


CONCLUSIONS
Both techniques are suitable for measuring the radiochemical purity of 99mTc-MAG3.
Millar
Alistair M
AM
Department of Radiopharmacy, The Royal Infirmary of Edinburgh, Little France Crescent, UK. alistair.millar@luht.scot.nhs.uk
Hesslewood
Stuart R
SR
D005591:Chemical Fractionation / Q000379:methods*; D002847:Chromatography, Agarose / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D011785:Quality Assurance, Health Care / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000302:isolation & purification; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017263:Technetium Tc 99m Mertiatide / Q000737:chemistry* / Q000302:isolation & purification*
D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide