title: [Spotted fever Rickettsiae. Their immunodominant proteins and immune response].
abstract: The organisms of Rickettsia species are gram (-) bacteria that cause severe illnesses in humans and are an important health problem in several countries around the world, including Mexico. The presence of different antigens between species and also in different strains of the same specie is an obstacle for vaccine development and serological diagnosis. There are important advances in the knowledge of the rickettsial antigenic structure and the resulting immune response in infected hosts, including humans. This review covers these topics and provides an overview about the development of vaccines and accessible diagnostic methods for diseases caused by Rickettsia.
authors.affiliation: Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Av. Itzaes No 490 x 59, CP 97000, Mérida Yucatán, México. zcastro@tunku.uady.mx
authors.forename: Jorge
authors.initials: J
authors.lastname: Zavala
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ruiz
authors.forename: Jorge
authors.initials: J
authors.lastname: Zavala
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology*; D001907:Boutonneuse Fever / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology*; D012281:Rickettsia / Q000276:immunology*; D012282:Rickettsia Infections / Q000175:diagnosis / Q000276:immunology*; D012290:Rickettsial Vaccines / Q000276:immunology
chemical_list: D001426:Bacterial Proteins; D016056:Immunodominant Epitopes; D012290:Rickettsial Vaccines
vernacular_title: Las Rickettsias del grupo de las fiebres manchadas: respuesta inmune y sus proteínas inmunodominantes.