Recurrent acute pancreatitis after isoniazid.
Drug-induced acute pancreatitis should be in the differential diagnosis of acute abdomen occurring soon after initiation of tuberculosis treatment and chemoprophylaxis. Isoniazid-induced pancreatitis is potentially reversible; early recognition and drug withdrawal are warranted in the appropriate clinical setting. We present a case of reversible acute pancreatitis after isoniazid treatment of genitourinary tuberculosis, followed by recurrence of pancreatitis 12 years later when the patient received isoniazid again for pulmonary tuberculosis. Isoniazid-induced pancreatitis, if highly suspicious or confirmed with re-challenge test, mandates permanent avoidance of the drug.
Chow
K M
KM
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China. Chow_Kai_Ming@alumni.cuhk.net
Szeto
C C
CC
Leung
C B
CB
Li
P K T
PK
D000208:Acute Disease; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D012008:Recurrence; D014376:Tuberculosis / Q000188:drug therapy
D000995:Antitubercular Agents; D007538:Isoniazid