Functional imaging in Lhermitte-Duclose disease.
OBJECTIVE
A comprehensive metabolic characterization of a patient with dysplastic gangliocytoma of the cerebellum or Lhermitte-Duclos Disease (LDD) is presented.


METHODS
Assessment using 2-deoxy-2-[18F]fluoro-D-glucose (FDG), carbon-11-labeled methionine (11C-MET), carbon-11-labeled choline (11C-Choline) positron emission tomography (PET), and 1H-proton magnetic resonance spectroscopy (MRS) was carried out in a 30-year-old Caucasian woman.


RESULTS
FDG-PET revealed hypermetabolism of the tumor. 11C-MET-PET revealed moderate uptake and 11C-Choline showed no uptake. 1H-MRS demonstrated an elevated level of lactate and decreased levels of choline (Cho) and myoinositol.


CONCLUSIONS
Functional imaging in LDD reflects the dual pathological features of neoplasm and hamartoma.
Padma
Madakasira V
MV
Wallace-Kettering Neurosciences Institute, Kettering Medical Center, OH 45429, USA.
Jacobs
Martin
M
Sequeira
Pam
P
Adineh
Mehdi
M
Satter
Martin
M
Kraus
Gary
G
Mantil
Joseph C
JC
D000328:Adult; D002531:Cerebellum / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005729:Ganglioneuroma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D049268:Positron-Emission Tomography; D011859:Radiography
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18