Tritium in [18O]water containing [18F]fluoride for [18F]FDG synthesis.
The presence of tritium in enriched [18O]water irradiated with 9.6 MeV protons used to produce [18F]fluoride by the 18O(p, n)18F reaction was inferred from the cross sections and threshold energies of the 18O(p, t)16O reaction, and the existence of tritium was confirmed experimentally. Tritium was also detected in both [18O]water recovered for recycling and waste acetonitrile solutions. The purified [18F]FDG was not contaminated with 3H. The amount of 3H discharged into the air was far less than the International Basic Safety Standard Level.
Ito
Shigeki
S
Radioisotope Research Center and Graduate School of Environmental Studies, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan.
Saze
Takuya
T
Sakane
Hitoshi
H
Ito
Satoshi
S
Ito
Shinichi
S
Nishizawa
Kunihide
K
D004340:Drug Contamination / Q000517:prevention & control; D005462:Fluorine Radioisotopes / Q000032:analysis* / Q000737:chemistry*; D019788:Fluorodeoxyglucose F18 / Q000032:analysis* / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D010103:Oxygen Isotopes / Q000032:analysis / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000032:analysis / Q000737:chemistry; D014316:Tritium / Q000032:analysis* / Q000737:chemistry*; D014867:Water / Q000032:analysis* / Q000737:chemistry
D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D014867:Water; D019788:Fluorodeoxyglucose F18; D014316:Tritium