title: Antioxidant lignans from Larrea tridentata.
abstract: Three lignans, (7S,8S,7'S,8'S)-3,3',4'-trihydroxy-4-methoxy-7,7'-epoxylignan, meso-(rel 7S,8S,7'R,8'R)-3,4,3',4'-tetrahydroxy-7,7'-epoxylignan, and (E)-4,4'-dihydroxy-7,7'-dioxolign-8(8')-ene, together with 10 known compounds, were isolated from the leaves of Larrea tridentata. The structures of the new compounds were determined primarily from 1D and 2D NMR spectroscopic analysis. Their antioxidant activities against intracellular reactive oxygen species were evaluated in HL-60 cells.
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Abou-Gazar
authors.forename: Erdal
authors.initials: E
authors.lastname: Bedir
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takamatsu
authors.forename: Daneel
authors.initials: D
authors.lastname: Ferreira
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D018922:HL-60 Cells; D006801:Humans; D032442:Larrea / Q000737:chemistry*; D017705:Lignans / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: C494253:(7S,8S,7'S,8'S)-3,3',4'-trihydroxy-4-methoxy-7,7'-epoxylignan; C494255:(E)-4,4'-dihydroxy-7,7'-dioxolign-8(8')-ene; D000975:Antioxidants; D017705:Lignans; C494254:meso-(rel 7S,8S,7'R,8'R)-3,4,3',4'-tetrahydroxy-7,7'-epoxylignan