title: Susceptibility of Mexican brucella isolates to moxifloxacin, ciprofloxacin and other antimicrobials used in the treatment of human brucellosis.
abstract: Brucellosis is a disease of domestic and wild animals that is transmitted to humans and exists worldwide. We assessed the in vitro activity of moxifloxacin, ciprofloxacin, tetracycline, doxicycline, rifampin, streptomycin and trimethoprim-sulfamethoxazole (TMP/SMX) against 97 Brucella strains isolated from clinical samples, animals and dairy products in Mexico. Fluoroquinolones showed an antibacterial activity similar to that of tetracyclines (MIC(90) 0.5). Other drugs commonly used against brucellosis were less active, such as rifampin (MIC(90) 2.0 microg/ml) and streptomycin (MIC(90) 4.0 microg/ml). TMP/SMX showed the poorest activity (MIC(90) 8.0 microg/ml). Fluoroquinolones, either first-generation or the newer 8-methoxi derivatives, might be useful in the therapy of brucellosis, which remains to be assessed in clinical trials.
authors.affiliation: Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, IPN, México D.F., 06400, México. ahide99@hotmail.com
authors.forename: Ahidé
authors.initials: A
authors.lastname: López-Merino
authors.forename: Araceli
authors.initials: A
authors.lastname: Contreras-Rodríguez
authors.forename: Roberto
authors.initials: R
authors.lastname: Migranas-Ortiz
authors.forename: Rubén
authors.initials: R
authors.lastname: Orrantia-Gradín
authors.forename: Gerardo M
authors.initials: GM
authors.lastname: Hernández-Oliva
authors.forename: Arturo Torres Y
authors.initials: AT
authors.lastname: Gutiérrez-Rubio
authors.forename: Oscar
authors.initials: O
authors.lastname: Cardeñosa
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D002002:Brucella / Q000187:drug effects* / Q000302:isolation & purification; D002006:Brucellosis / Q000188:drug therapy / Q000453:epidemiology; D002939:Ciprofloxacin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D011804:Quinolines / Q000494:pharmacology*; D012680:Sensitivity and Specificity
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D002939:Ciprofloxacin; D000077266:Moxifloxacin