Publication of clinical trials: accountability and accessibility.
Publication of findings from clinical trials is a necessary step in the research continuum, to provide a record of the work done, convey information to the community, and support translation of research into clinical practice. Systematic reviews of randomized controlled trials are now widely regarded as the highest level of evidence in determining the effect of an intervention on an outcome. They largely depend on internationally accessible, published reports of all trials undertaken. Investigators and their institutions or organizations have responsibility for reporting their clinical trials accurately and completely, including disclosure of potential conflicts of interest. To ensure evidence-based health care, issues relating to accessibility and accountability of clinical trial results require immediate action.
Tumber
M B
MB
Department of Community Health, Brown University, 167 Angell Street, Providence, RI 02912, USA. marea_tumber@brown.edu
Dickersin
K
K
D001319:Authorship; D016265:Conflict of Interest; D017408:Guidelines as Topic; D006801:Humans; D033181:Information Dissemination / Q000379:methods; D010506:Periodicals as Topic; D011643:Publishing; D016032:Randomized Controlled Trials as Topic / Q000592:standards; D012941:Social Responsibility