Effect of oral L-arginine on oxidant stress, endothelial dysfunction, and systemic arterial pressure in young cardiac transplant recipients.
Oral L-arginine therapy reverses endothelial dysfunction and attenuates high blood pressure in hypertensive cardiac transplant recipients. L-arginine corrects derangements in the vascular endothelial nitric oxide (NO)-dependent signaling pathway. Our data support the concept that cardiac transplant recipients use excess endogenous NO from L-arginine supplementation to buffer increased vascular oxidant stress.
Lim
D Scott
DS
Department of Pediatrics, University of Virginia, Charlottesville, VA 22908-0386, USA. SL9PC@virginia.edu
Mooradian
Stephen J
SJ
Goldberg
Caren S
CS
Gomez
Carlen
C
Crowley
Dennis C
DC
Rocchini
Albert P
AP
Charpie
John R
JR
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D002648:Child; D003331:Coronary Vessels / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D018384:Oxidative Stress
D001120:Arginine