Recent advances in small molecule microarrays: applications and technology.
The field of Small Molecule Microarray's (SMM's) is an ever-expanding part of the larger microarray field. SMM's are array based detection systems that use small molecules as probes immobilized on a variety of microarray surfaces that are screened against a number of targets for purposes including, but not limited to, protein-small molecule ligand recognition and protein function profiling. This review covers the recent advances in the field with particular emphasis on the successful applications of SMM's, as well as technical advances in platform optimization and novel small molecule immobilization strategies.
Walsh
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New York University, Department of chemistry, 29 Washington place, room 551, New York, NY 10003, USA.
Chang
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YT
D000818:Animals; D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques / Q000639:trends; D006801:Humans; D008024:Ligands; D008832:Microchemistry / Q000379:methods*; D015336:Molecular Probe Techniques / Q000639:trends*; D015335:Molecular Probes; D013499:Surface Properties
D008024:Ligands; D015335:Molecular Probes