4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists.
Synthesis, in vitro biological evaluation and structure-activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.
Receveur
Jean-Marie
JM
7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark.
Bjurling
Emelie
E
Ulven
Trond
T
Little
Paul Brian
PB
Nørregaard
Pia K
PK
Högberg
Thomas
T
D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D007028:Hypothalamic Hormones / Q000378:metabolism*; D008024:Ligands; D008543:Melanins / Q000378:metabolism*; D010907:Pituitary Hormones / Q000378:metabolism*; D011869:Radioligand Assay; D011979:Receptors, Pituitary Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D001549:Benzamides; D007028:Hypothalamic Hormones; D008024:Ligands; D008543:Melanins; D010907:Pituitary Hormones; D011979:Receptors, Pituitary Hormone; C019463:melanin-concentrating hormone; D014508:Urea