title: Forearm endothelial function and bone mineral loss in postmenopausal women.
abstract: It is widely believed that the vasculature plays an important role in bone remodeling. We investigated the relationship between forearm endothelial function and bone mass in the lumbar spine in early postmenopausal women without a history of smoking or diabetes mellitus. We studied the forearm resistance artery endothelial function in 110 Japanese women-52 postmenopausal women with normal spinal bone mineral density (BMD), 36 postmenopausal women with osteopenia, and 22 osteoporotic postmenopausal women. Forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography. BMD of the lumbar spine (L2-L4) was measured by dual-energy X-ray absorptiometry. After adjustment for age, body mass index, years since the start of menopause, and basal FBF, women with osteoporosis had a lower maximal FBF response to reactive hyperemia (28.4 +/- 3.8 mL/min per 100 mL tissue) than those with normal BMD (39.8 +/- 2.8 mL/min per 100mL tissue) or osteopenia (35.6 +/- 2.5 mL/min per 100mL tissue) (P = 0.029). A significant increase in serum angiotensin-converting enzyme (ACE) activity (P = 0.042) and a significant decrease in the serum concentrations of nitrite/nitrate (P = 0.041) were noted in osteoporotic women compared to women with normal BMD or osteopenia. The present findings suggest that postmenopausal women with low BMD, especially those with osteoporosis, have impaired endothelial function in the forearm resistance arteries.
authors.affiliation: Department of Obstetrics and Gynecology, Sanada Hospital, Graduate School of Biomedical Sciences, Hiroshima University, 3-13-21 Minami-machi, Minami-ku, Hiroshima 734 0007, Japan. msanada64@hotmail.com
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Sanada
authors.forename: Akira
authors.initials: A
authors.lastname: Taguchi
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Higashi
authors.forename: Mikio
authors.initials: M
authors.lastname: Tsuda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kodama
authors.forename: Masao
authors.initials: M
authors.lastname: Yoshizumi
authors.forename: Koso
authors.initials: K
authors.lastname: Ohama
mesh_terms: D015502:Absorptiometry, Photon; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000503:physiopathology; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D008159:Lumbar Vertebrae; D008875:Middle Aged; D010024:Osteoporosis / Q000503:physiopathology*; D017698:Postmenopause; D012039:Regional Blood Flow; D014655:Vascular Resistance / Q000502:physiology*