Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion.
Autoantibodies may cause severe hemolytic anemia, but only rarely are they the cause of a hemolytic transfusion reaction due to the destruction of transfused allogeneic blood. In two patients, autoantibody was detected shortly after blood transfusion. The first case was a D-negative patient who produced an autoanti-Ce and subsequently developed hemoglobinuria and hyperbilirubinemia. The second case was a patient who developed an autoanti-Wrb that caused severe hemolysis that resulted in death.
Chan
D
D
National Blood Service, South West, Southmead Road, Bristol BS10 5ND, UK.
Poole
G D
GD
Binney
M
M
Hamon
M D
MD
Copplestone
J A
JA
Prentice
A G
AG