title: Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure.
abstract: gp130 is a common signal-transducing receptor subunit for the interleukin (IL)-6 cytokine family. Studies in genetically engineered animal models have demonstrated a critical role for the gp130-dependent cardiomyocyte survival pathway in the transition to heart failure. In the present study, we examined plasma levels of the IL-6 family of cytokines and the soluble form of their receptors in patients with congestive heart failure (CHF). Circulating levels of the IL-6 family of cytokines, soluble IL-6 receptor (sIL-6R), and soluble gp130 (sgp130) were examined in 48 patients with various degrees of CHF, including dilated cardiomyopathy (DCM), ischemic cardiomyopathy (ICM), and valvular cardiomyopathy (VCM). Circulating levels of IL-6, leukemia inhibitory factor (LIF), and sgp130 significantly increased in association with the severity of CHF. No significant difference was observed in the circulating levels of sIL-6R and IL-11 among these patients. Interestingly, DCM patients showed higher circulating sgp130 levels than patients with ICM or VCM. Our findings suggest that gp130 expression in the heart is likely to be dynamic, and that the IL-6 family of cytokines and their common receptor gp130 participates in the pathogenesis of CHF, especially in DCM.
authors.affiliation: Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Hirota
authors.forename: Masahiro
authors.initials: M
authors.lastname: Izumi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Hamaguchi
authors.forename: Shoko
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Eiki
authors.initials: E
authors.lastname: Murakami
authors.forename: Keita
authors.initials: K
authors.lastname: Kunisada
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujio
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oshima
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakaoka
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi-Takihara
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000503:physiopathology; D050822:Cytokine Receptor gp130; D004797:Enzyme-Linked Immunosorbent Assay / Q000295:instrumentation; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D017370:Interleukin-11 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D053605:Leukemia Inhibitory Factor; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D020097:Natriuretic Peptide, Brain / Q000097:blood; D019947:Receptors, Interleukin-6 / Q000097:blood*
chemical_list: D015703:Antigens, CD; C494199:IL6ST protein, human; D017370:Interleukin-11; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008562:Membrane Glycoproteins; D019947:Receptors, Interleukin-6; D020097:Natriuretic Peptide, Brain; D050822:Cytokine Receptor gp130