Most effective stimulation site in subthalamic deep brain stimulation for Parkinson's disease.
The optimal stimulation site in subthalamic deep brain stimulation (STN-DBS) was evaluated by correlation of the stereotactic position of the stimulation electrode with the electrophysiologically specified dorsal STN border. In a series of 25 electrodes, best clinical results with least energy consumption were found in contacts located in the dorsolateral border zone, whereas contacts within the subthalamic white matter, e.g., zona incerta, were significantly less effective. We suggest that the dorsolateral STN border should be covered by STN-DBS.
Herzog
Jan
J
Department of Neurology, Christian-Albrechts-Universität Kiel, Germany.
Fietzek
Urban
U
Hamel
Wolfgang
W
Morsnowski
Andre
A
Steigerwald
Frank
F
Schrader
Bettina
B
Weinert
Dieter
D
Pfister
Gerd
G
Müller
Dieter
D
Mehdorn
Hubertus M
HM
Deuschl
Günther
G
Volkmann
Jens
J
D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004567:Electrodes, Implanted; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D013378:Substantia Nigra / Q000473:pathology; D020531:Subthalamic Nucleus / Q000473:pathology / Q000502:physiology*