title: Characterization of a novel immunoglobulin-like domain containing receptor.
abstract: A not yet described gene was identified in a lymphoma specific subtraction strategy. Three splice variants of this gene denoted immunoglobulin-like domain containing receptor 1 (ILDR1) were identified and characterized. Cellular localization studies showed membrane-association for two of the variants, while the third was cytoplasmic and appeared to translocate to the membrane upon co-expression with any of the other two isoforms. ILDR1 shows approximately 30% homology to a recently described protein from rat, lipolysis stimulated receptor, that has been shown to bind low-density lipoprotein. The gene encoding ILDR1 is localized to chromosome 3q21.1 and it is expressed in prostate, testis, pancreas, kidney, liver, and heart. Interestingly, the shortest transcript corresponding to the cytoplasmic variant could only be detected in lymphoma samples and not in normal tissues or cell lines tested. The expression of this variant may therefore be related to the development and/or progression of cancer.
authors.affiliation: Department of Immunology, The Norwegian Radium Hospital, Oslo, Norway.
authors.forename: Helena
authors.initials: H
authors.lastname: Hauge
authors.forename: Sebastian
authors.initials: S
authors.lastname: Patzke
authors.forename: Jan
authors.initials: J
authors.lastname: Delabie
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Aasheim
mesh_terms: D000595:Amino Acid Sequence; D014408:Biomarkers, Tumor / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D008223:Lymphoma / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009928:Organ Specificity; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid; D013347:Subcellular Fractions / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D014408:Biomarkers, Tumor; C493788:ILDR1 protein, human; D011956:Receptors, Cell Surface