title: Expression of Alzheimer's amyloid precursor protein in human lymphocyte.
abstract: Beta-amyloid precursor protein (betaAPP) has been shown to be involved in cell growth regulation. In spleen, the majority of cells showing betaAPP like immunoreactivity was found in the T cell-dependent zone. In Northern blot, the expression of betaAPP was increased to reach the peak at 72 h after the treatment of phytohemagglutinin (PHA). But, in cytofluorometry, almost all CD4(+) T helper/inducer cells and the majority of CD(8+) T suppressor/cytotoxic cells show betaAPP immunoreactivity which remained constant during the stimulation with PHA. These results suggest that betaAPP is a surface molecule of T lymphocyte and the turnover or release of APP might be increased with the treatment of T cell mitogen.
authors.affiliation: Department of Pharmacology, College of Medicine, Neuroscience Research Institute, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-799, South Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Suh
authors.forename: W
authors.initials: W
authors.lastname: Choi
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: B Y
authors.initials: BY
authors.lastname: Rhi
authors.forename: Y H
authors.initials: YH
authors.lastname: Chong
authors.forename: J I
authors.initials: JI
authors.lastname: Woo
authors.forename: K W
authors.initials: KW
authors.lastname: Lee