Safety and efficacy of infertility treatment after conservative management of borderline ovarian tumors: a preliminary report.
OBJECTIVE
To evaluate the safety and efficacy of infertility treatment in a group of patients after conservative management of borderline ovarian tumors.


METHODS
Retrospective study.


METHODS
University IVF unit.


METHODS
Five patients with previous conservative treatment of borderline ovarian tumor.


METHODS
Seventeen IVF cycles.


METHODS
Recurrence, IVF outcome.


RESULTS
At the time of diagnosis, the mean age of the patients was 32.2 +/- 6.9 years. The mean time elapsed between the initial diagnosis of a borderline tumor and the performance of IVF was 42.2 months. After IVF, the mean number of oocytes retrieved was 7.9 +/- 4.0 with a mean fertilization rate of 57.1% and a mean number of 3.1 +/- 1.4 day 3 embryos transferred. Six pregnancies were achieved in three of the five patients with a pregnancy rate per retrieval of 37.5% and per transfer of 42.9%. The mean follow-up time that elapsed since the first IVF cycle was 39.2 months (range 9-78 months). One patient had three recurrences 13, 27, and 43 months after her first IVF cycle, all of which remained histologically serous borderline tumor. All patients were without evidence of disease at the time of last follow-up.


CONCLUSIONS
At a mean follow-up time of 39.2 months, our results suggest that IVF may be considered for patients with conservatively treated borderline tumors. Furthermore, overall IVF success rates were very satisfactory, suggesting no perceptible negative impact of prior borderline ovarian neoplasia on pregnancy rates after IVF.
Fasouliotis
Sozos J
SJ
Center for Reproductive Medicine and Infertility, Weill Medical College at Cornell University, 505 East 70th Street, New York, NY 10021, USA. sjf2002@med.cornell.edu
Davis
Owen
O
Schattman
Glenn
G
Spandorfer
Steven D
SD
Kligman
Isaac
I
Rosenwaks
Zev
Z
D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D008499:Medical Records; D010051:Ovarian Neoplasms / Q000150:complications / Q000601:surgery*; D011247:Pregnancy; D012008:Recurrence; D012189:Retrospective Studies