MPTP as a mitochondrial neurotoxic model of Parkinson's disease.
1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria play a pivotal role, drives MPTP neurotoxicity. How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review.
Przedborski
Serge
S
Department of Neurology, Columbia University, New York, New York 10032, USA. sp30@columbia.edu
Tieu
Kim
K
Perier
Celine
C
Vila
Miquel
M
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004195:Disease Models, Animal; D020267:MPTP Poisoning / Q000139:chemically induced* / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000139:chemically induced / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism*; D009498:Neurotoxins / Q000633:toxicity; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
D024101:Mitochondrial Proteins; D009498:Neurotoxins; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine