[Mucinous cholangiocarcinoma associated with Clonorchis sinensis infestation: a case report].
Mucinous cholangiocarcinoma, characterized by large quantities of mucin production, is a rare subtype of peripheral cholangiocarcinoma and usually shows rapid progression and a fatal outcome. We report here a case of mucinous cholangiocarcinoma in a 69 year-old man, who was infected with Clonorchis sinensis. Histologically, the tumor was an adenocarcinoma with extensive intracellular and extracellular mucin production, up to 70% of the tumor mass and there was frequent lymphovascular invasion of the tumor cells. The liver adjacent to the mass contained eggs of Clonorchis sinensis in the bile duct lumen and showed ductal epithelial hyperplasia, mucinous metaplasia and adenomatous proliferation of intramural glands. The patient was treated with a right hepatectomy. Four months after the surgery, the tumor recurred in the soft tissue of the right flank.
Shim
Hyo Sup
HS
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Lim
Beom Jin
BJ
Kim
Myeong-Jin
MJ
Lee
Woo Jung
WJ
Park
Chanil
C
Park
Young Nyun
YN
D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications* / Q000378:metabolism; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000150:complications* / Q000378:metabolism; D003003:Clonorchiasis / Q000150:complications*; D006801:Humans; D008297:Male; D009077:Mucins / Q000378:metabolism
D009077:Mucins