title: Change with donor age in the degradation rate of endogenous proteins of mouse hepatocytes in primary culture.
abstract: The degradation rate of [(3)H]leucine labeled intracellular proteins was compared in hepatocytes derived from young (4-7-month-old) and aged (23-month-old) mice. Average half-lives of long-lived proteins were 40 h and 65 h in the cells from young and old animals, respectively. This observation confirms our earlier results that half-lives of foreign proteins introduced into the cells from old mice are 50-60% longer than those of younger counterparts (Ishigami and Goto, 1988, Mech. Ageing Dev., 46, 125-133; Ishigami and Goto, 1990, Arch. Biochem. Biophys., 277, 189-195).
authors.affiliation: Department of Biochemistry, School of Pharmaceutical Science, Toho University, Miyama, Funabashi, Chiba, 274 Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: A
authors.initials: A
authors.lastname: Ishigamia
authors.forename: K
authors.initials: K
authors.lastname: Anzai
authors.forename: S
authors.initials: S
authors.lastname: Goto