Retracted: Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody.
CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
Di Paola
Rosanna
R
Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica-Policlinico Universitario, Messina, Italy.
Di Marco
Roberto
R
Mazzon
Emanuela
E
Genovese
Tiziana
T
Bendtzen
Klaus
K
Macrì
Battesimo
B
Nicoletti
Ferdinando
F
Cuzzocrea
Salvatore
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology*; D053285:CD30 Ligand; D002351:Carrageenan / Q000009:adverse effects; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D017730:Ki-1 Antigen / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D019007:P-Selectin / Q000378:metabolism; D010998:Pleurisy / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000911:Antibodies, Monoclonal; D053285:CD30 Ligand; D017730:Ki-1 Antigen; D008562:Membrane Glycoproteins; D019007:P-Selectin; C505775:Tnfsf8 protein, mouse; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; C002744:3-nitrotyrosine; D014443:Tyrosine; D002351:Carrageenan