title: Complete assignment of 1H and 13C NMR data for three aryltetralin lignan lactones.
abstract: We describe the complete 1H and 13C NMR analysis of three aryltetralin lignan lactones (polygamain, morelensin and 4,5-dimethoxymorelensin) using modern NMR techniques such as COSY, HMQC, HMBC, 2D-J-resolved and NOE experiments. The relative stereochemistry of these compounds, which is very important with regard to their biological activity, was completely determined.
authors.affiliation: Departamento de Análises Clínicas, Toxicológicas e Bromatológicas da Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, 14040-903 Ribeirão Preto, SP, Brazil. rosilva@usp.br
authors.forename: Rosangela
authors.initials: R
authors.lastname: da Silva
authors.forename: Vladimir Constantino Gomes
authors.initials: VC
authors.lastname: Heleno
authors.forename: Sérgio
authors.initials: S
authors.lastname: de Albuquerque
authors.forename: Jairo Kenupp
authors.initials: JK
authors.lastname: Bastos
authors.forename: Márcio Luis
authors.initials: ML
authors.lastname: Andrade e Silva
authors.forename: Paulo Marcos
authors.initials: PM
authors.lastname: Donate
authors.forename: Gil Valdo José
authors.initials: GV
authors.lastname: da Silva
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry*; D001681:Biological Assay; D002247:Carbon Isotopes; D004149:Dioxoles / Q000138:chemical synthesis / Q000737:chemistry*; D006859:Hydrogen; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry*; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: C499778:4,5-dimethoxymorelensin; D001572:Benzofurans; D002247:Carbon Isotopes; D004149:Dioxoles; D007783:Lactones; D017705:Lignans; C499777:morelensin; C499776:polygamain; D006859:Hydrogen