title: Antioxidants in peripheral arterial disease.
abstract: Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggest a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamin supplementation should be recommended for PAD patients.
authors.affiliation: Divisione IV Clinica Medica, Policlinico Umberto I, Università "La Sapienza", Rome, Italy. francesco.violi@uniroma1.it
authors.forename: F
authors.initials: F
authors.lastname: Violi
authors.forename: L
authors.initials: L
authors.lastname: Loffredo
authors.forename: A
authors.initials: A
authors.lastname: Marcoccia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002986:Clinical Trials as Topic; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D018384:Oxidative Stress; D016491:Peripheral Vascular Diseases / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL