CO sniffing through heme-based sensor proteins.
O(2), NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O(2) respiration, denitrification, N(2) fixation, and methanogenesis. Over the last decade, O(2), NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.
Ascenzi
Paolo
P
Department of Biology and the Interdepartmental Laboratory for Electron Microscopy University Roma Tre, Viale G. Marconi 446, I-00146 Rome, Italy. ascenzi@bio.uniroma3.it
Bocedi
Alessio
A
Leoni
Livia
L
Visca
Paolo
P
Zennaro
Elisabetta
E
Milani
Mario
M
Bolognesi
Martino
M
D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism*; D006418:Heme / Q000378:metabolism; D006420:Hemeproteins / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D001426:Bacterial Proteins; D006420:Hemeproteins; D014157:Transcription Factors; D006418:Heme; D002248:Carbon Monoxide