Isolation and identification of a new thymic peptide from calf thymus.
Various thymic peptides (including thymulin, thymic humoral factor, thymopoietin, etc.) play important roles in the process of T cell maturation and development. We isolated a new peptide from calf thymus and named it thymus activity factor II (TAF-II). A yield of 0.92 mg of TAF-II was purified from 500 g calf thymus. Analysis by LC/MSD-Trap showed the amino acid sequence of this hexapeptide to be Glu-Ala-Lys-Ser-Gln-Gly-OH with molecular weight 618.5 daltons. We have also begun to investigate the influence of TAF-II.
Qin
Xi-Ming
XM
State Key Laboratory of Biomembranes and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China.
Duan
Ming-Xing
MX
Deng
Bin
B
Liu
Xi-Cheng
XC
Zhang
Qiang-Zhe
QZ
Liu
Zheng
Z
He
Hong-Xuan
HX
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008970:Molecular Weight; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013949:Thymus Extracts / Q000737:chemistry; D013950:Thymus Gland / Q000737:chemistry*; D014462:Ultrafiltration
D009842:Oligopeptides; D013949:Thymus Extracts