Stopping for FISH and chips along the chromatin fiber superhighway.
Gilbert et al. (2004) report in a recent issue of Cell on the analysis of chromatin fiber structure across the human genome. They show that compact chromatin fibers are composed of heterochromatin but also contain some active genes, while open chromatin fibers correlate with regions of highest gene density, but not with gene expression.
Spector
David L
DL
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
D002843:Chromatin / Q000737:chemistry / Q000235:genetics*; D002871:Chromosome Banding; D022041:Euchromatin / Q000378:metabolism; D015894:Genome, Human; D006570:Heterochromatin / Q000378:metabolism; D006801:Humans; D017404:In Situ Hybridization, Fluorescence
D002843:Chromatin; D022041:Euchromatin; D006570:Heterochromatin