title: Serum ascorbic acid concentrations in previously unsupplemented greyhounds after administration of a single dose of ascorbic acid intravenously or per os.
abstract: Plasma vitamin C concentrations (mean + SD) were measured after a large (1 g) dose of vitamin C was administered orally or intravenously to each of four trained greyhounds in a randomized cross-over design. Concentrations increased (p<0.05) for 2 h but returned to baseline by 6 h after supplementation. Peak concentrations were greater (p<0.01) after intravenous than oral administration (6.1+/-1.2 vs. 0.54+/-0.23 mg/dl). This suggests that vitamin C must be administered many times daily to maintain plasma concentrations above normal.
authors.affiliation: Department of Small Animal Clinical Sciences and the Center for Veterinary Sports Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
authors.forename: K C
authors.initials: KC
authors.lastname: Scott
authors.forename: R C
authors.initials: RC
authors.lastname: Hill
authors.forename: D D
authors.initials: DD
authors.lastname: Lewis
authors.forename: R
authors.initials: R
authors.lastname: Gronwall
authors.forename: D A
authors.initials: DA
authors.lastname: Sundstrom
authors.forename: G L
authors.initials: GL
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Harper
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000097:blood*; D018592:Cross-Over Studies; D004285:Dogs / Q000097:blood*; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D011897:Random Allocation
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid