The intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism is not associated with ischaemic heart disease: an investigation using family-based tests of association.
The possible role of the K469E polymorphism in the intercellular adhesion molecule-1 (ICAM-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family-based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped for the ICAM-1 K469E polymorphism. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the ICAM-1 K469E polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the ICAM-1 K469E polymorphism is not associated with IHD.
McGlinchey
P G
PG
Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, UK.
Spence
M S
MS
Patterson
C C
CC
Allen
A R
AR
Murphy
G
G
Belton
C
C
McKeown
P P
PP
D000328:Adult; D017668:Age of Onset; D019943:Amino Acid Substitution; D003062:Codon / Q000235:genetics; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D007494:Ireland / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D035781:Siblings; D044465:White People / Q000235:genetics
D003062:Codon; D018799:Intercellular Adhesion Molecule-1