title: Current advances in bone health of disabled children.
abstract: OBJECTIVE
  Bone health is now recognized to contribute to overall lifetime management of children, adolescents, and adults with disabling conditions including physical and intellectual disability and with many chronic disease processes. Such disorders have multiple components, with aspects of care covering a wide number of specialist practices. This review will highlight advances in understanding the nature of bone mass accumulation through childhood and adolescence, the impingement of a spectrum of chronic and disabling diseases and their treatments on bone, and will address current approaches to interpretation of bone mass in the growing skeleton and interventional strategies for improving outcomes for this group.
  
  
  RESULTS
  Increased skeletal fragility in the disabled child is well recognized. Insights into the contributions of skeletal size and bone strength in males and females have altered interpretation of data, allowing a new focus on determinants of future bone health, particularly with regard to the contributions of growth and puberty. Strategies to address bone health including public and medical education concerning consumption of calcium, appropriate selection of vitamin D preparations, pubertal contribution to phases of growth and possible specialist use of newer drugs, such as bisphosphonates where indicated, are changing the outlook for this large group.
  
  
  CONCLUSIONS
  Implications of these changed understandings provide a new focus on maximizing bone mass accumulation by the end of adolescence within the constraints of what is possible to achieve for an individual and for provision of an holistic approach to bone health.
authors.affiliation: Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville 3052, Victoria, Australia. margaret.zacharin@rch.org.au
authors.forename: Margaret
authors.initials: M
authors.lastname: Zacharin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000328:Adult; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D002648:Child; D019988:Children with Disabilities; D006801:Humans; D010024:Osteoporosis / Q000378:metabolism / Q000517:prevention & control; D011627:Puberty / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000305:Adrenal Cortex Hormones; D014807:Vitamin D; D002118:Calcium