title: Efficient preparation of glycoclusters from silsesquioxanes.
abstract: [structure: see text] A new type of glycocluster based on polyhedral oligosilsesquioxanes (POSS) has been efficiently prepared from unprotected mannoside and lactoside employing a convergent approach of thiol-radical addition reaction. The versatility of this approach was demonstrated by functionalization of mannosides and lactosides of different-length spacers.
authors.affiliation: Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Gao
authors.forename: Atsuko
authors.initials: A
authors.lastname: Eguchi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kakehi
authors.forename: Yuan C
authors.initials: YC
authors.lastname: Lee
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006023:Glycoproteins / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry*; D006801:Humans; D008362:Mannosides / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017646:Organosilicon Compounds / Q000737:chemistry*
chemical_list: D006023:Glycoproteins; D006027:Glycosides; D008362:Mannosides; D009844:Oligosaccharides; D017646:Organosilicon Compounds; C008245:lactosides