Blasts from the past: new lessons in stem cell biology from chronic myelogenous leukemia.
Cancer can be viewed as a hierarchical system that is dependent on a small population of "cancer stem cells" with unlimited self-renewal potential for continued growth and propagation of tumors. The identity and nature of these cells remains enigmatic, but an improved understanding of their biology may allow for selective therapeutic targeting. A recent report by sheds new light on leukemia stem cells by identifying the cells with in vitro self-renewing properties in various phases of chronic myelogenous leukemia, and linking the self-renewal properties of this population to activation of beta-catenin, a major effector of the canonical Wnt signaling pathway.
Huntly
Brian J P
BJ
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. bhuntly@rics.bwh.harvad.edu
Gilliland
D Gary
DG
D002455:Cell Division; D019070:Cell Lineage; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D016503:Drug Delivery Systems; D006410:Hematopoiesis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology; D015534:Trans-Activators / Q000378:metabolism*; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin