Characteristics of the behavior and stress-reactivity of the hypophyseal-adrenal system in prenatally stressed rats.
The effects of daily 1-h immobilization of female rats from days 15 to 18 of pregnancy on the levels of anxiety, orientational-investigative activity in an open field test, and the dynamics of the stress response of the hypophyseal-adrenal system were studied in the male and female adult offspring of these rats. Maternal stress was found to induce significant reductions in the level of orientational-investigative activity of females in the stage of diestrus, and to increase anxiety as measured in an elevated cross maze. Prenatally stressed males, conversely, had decreased levels of anxiety, and behavior in the open field test was virtually unaltered. As a result, prenatally stressed rats showed smoothing out of the intergender differences in these forms of behavior, seen in control animals in normal conditions. Prenatal stress had a significant influence on the dynamics of the stress response of the hypophyseal-adrenal system in males and females; males showed impairment of the feedback control of this system in conditions of stress activation, while females showed significant increases in the maximum level of adrenal corticosterone secretion into the blood in response to immobilization lasting 20 min. These data provide evidence that maternal stress has significant influences on behavior and the stress response in both male and female rats.
Ordyan
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I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia.
Pivina
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D000818:Animals; D001007:Anxiety / Q000097:blood / Q000503:physiopathology; D001522:Behavior, Animal / Q000502:physiology*; D003345:Corticosterone / Q000097:blood*; D005106:Exploratory Behavior / Q000502:physiology; D025461:Feedback, Physiological; D005260:Female; D007103:Immobilization; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*
D003345:Corticosterone