Effects of amifostine on healing of microvascular anastomoses, flap survival, and nerve regeneration with preoperative or postoperative irradiation.
Amifostine is an organic thiophosphate compound, which has both cytoprotective and radioprotective effects. An experimental study was undertaken to investigate the effects of its use on reconstructive surgery in cancer treatment. One hundred and twenty guinea pigs were divided into three equal groups to investigate flap survival and healing, patency of microvascular anastomoses, and nerve regeneration, respectively. The groups were subdivided in such a way that they were given either preoperative or postoperative radiotherapy, with or without amifostine treatment. Macroscopic and planimetric examination, light and electron microscopy, and histomorphometric analyses were performed to evaluate flap survival and healing, patency of arterial anastomoses, and nerve regeneration. Although flap survival rates were not affected, significantly better flap healing was observed in the postoperative radiotherapy subgroup with amifostine treatment. However, amifostine treatment did not result in a statistically significant difference in terms of anastomotic patency and nerve regeneration with either preoperative or postoperative radiotherapy.
Aydin
Atakan
A
Division of Hand Surgery, Department of Plastic and Reconstructive Surgery, Istanbul Medical Faculty, Istanbul, Turkey. atakanaydin@yahoo.com
Ozden
Burcu Celet
BC
Mezdeği
Ali
A
Kurul
Sidika
S
Meral
Rasim
R
Solakoğlu
Seyhun
S
D004999:Amifostine / Q000494:pharmacology*; D000704:Analysis of Variance; D000714:Anastomosis, Surgical; D000818:Animals; D001707:Biopsy, Needle; D006084:Graft Rejection; D006085:Graft Survival; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D008866:Microsurgery / Q000379:methods; D009416:Nerve Regeneration / Q000187:drug effects* / Q000528:radiation effects*; D011182:Postoperative Care; D011300:Preoperative Care / Q000379:methods; D011336:Probability; D011829:Radiation Dosage; D011897:Random Allocation; D019651:Plastic Surgery Procedures / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013524:Surgical Flaps / Q000098:blood supply*; D014656:Vascular Surgical Procedures / Q000379:methods; D014945:Wound Healing / Q000187:drug effects* / Q000528:radiation effects*
D004999:Amifostine