title: Antifungal therapy of murine Aspergillus terreus infection.
abstract: Aspergillus terreus is a species which is being seen increasingly frequently and which is highly resistant to amphotericin B in vitro and clinically. We evaluated amphotericin B, caspofungin, and posaconazole in a murine model of acute invasive aspergillosis. Caspofungin and posaconazole both appeared beneficial and may be reasonable treatment alternatives for infection with A. terreus.
authors.affiliation: The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases (mail code 7881), 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Graybill
authors.forename: Steve
authors.initials: S
authors.lastname: Hernandez
authors.forename: Rosie
authors.initials: R
authors.lastname: Bocanegra
authors.forename: Laura K
authors.initials: LK
authors.lastname: Najvar
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009503:Neutropenia / Q000188:drug therapy; D013534:Survival
chemical_list: D000935:Antifungal Agents