title: Mini-review: overcoming tumor-intrinsic resistance to immune effector function.
abstract: In immunological cancer therapy, the current treatment emphasis is on the generation of effector cells that are specific for tumor antigens. However, there is a distressing lack of correlation between the induction of specific immunity in cancer patients and measurable clinical benefit. By studying mouse models of de novo tumorigenesis we are beginning to understand that the tumor itself, in particular the manifestation of a distinct tumor environment, impairs immune effector function; this concept is yet to be applied in human malignancy.
authors.affiliation: Department of Molecular Immunology, German Cancer Research Center, Heidelberg, Germany. r.ganss@dkfz.de
authors.forename: Ruth
authors.initials: R
authors.lastname: Ganss
authors.forename: Bernd
authors.initials: B
authors.lastname: Arnold
authors.forename: Günter J
authors.initials: GJ
authors.lastname: Hämmerling
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines