title: Synthesis of microfolicoumarin, a constituent of Cedrelopsis microfoliata.
abstract: Microfolicoumarin (1), a prenylcoumarin from Cedrelopsis microfoliata, was synthesized from 2,4,5-trimethoxybenzaldehyde in five steps. 1 did not show significant antioxidative activity, but the key intermediates, esculetin (3) and 5-prenylesculetin (6), exhibited strong antioxidative activity in both the superoxide-radical and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging models.
authors.affiliation: Laila Impex R & D Centre, Unit 1, Phase III, Jawahar Autonagar, Vijayawada, India.
authors.forename: Marellapudi S
authors.initials: MS
authors.lastname: Ramachandra
authors.forename: Somepalli
authors.initials: S
authors.lastname: Venkateswarlu
authors.forename: Gottumukkala V
authors.initials: GV
authors.lastname: Subbaraju
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000975:Antioxidants; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D016166:Free Radical Scavengers; D019684:Magnoliopsida / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013481:Superoxides
chemical_list: D000447:Aldehydes; D000975:Antioxidants; D003374:Coumarins; D016166:Free Radical Scavengers; D013481:Superoxides