title: Effects of GM-CSF on the neural progenitor cells.
abstract: Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent hematopoietic cytokine, which stimulates stem cell proliferation in the bone marrow. We now report that GM-CSF receptors expressed on neural progenitor cells and can mediate a biological response in cells to treat with GM-CSF treated neural progenitor cells exhibited a proliferative response and a marked decrease in terminal differentiation to mature neuron or astrocytes. GM-CSF treatment also suppressed neural progenitor cell apoptosis. These findings suggest that GM-CSF can stimulate the proliferation and inhibit the apoptosis of neural progenitor cells to expand the progenitor population, and that GM-CSF has a potential role in neural development or repair.
authors.affiliation: Department of Neurosurgery, Inha University College of Medicine, 7-206, shinheung-dong 3ga, Chung-gu, Inchon, Korea.
authors.forename: Jin Kyun
authors.initials: JK
authors.lastname: Kim
authors.forename: Byung Hyun
authors.initials: BH
authors.lastname: Choi
authors.forename: Hyung Chun
authors.initials: HC
authors.lastname: Park
authors.forename: So Ra
authors.initials: SR
authors.lastname: Park
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Yoon
authors.forename: Hyun Seon
authors.initials: HS
authors.lastname: Park
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Yoon
authors.initials: Y
authors.lastname: Ha
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000819:agonists / Q000096:biosynthesis; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor