Why calcium-stimulated adenylyl cyclases?
The Ca(2+)/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca(2+) increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.
Ferguson
Gregory D
GD
Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
Storm
Daniel R
DR
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D009474:Neurons / Q000201:enzymology*; D015398:Signal Transduction / Q000502:physiology*
D002147:Calmodulin; D000262:Adenylyl Cyclases; D002118:Calcium