Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor.
Pyrimidine methyl anilines as potent and selective mGlu2 potentiators are described. Findings from the structure-activity-relationship investigations are discussed.
Hu
Essa
E
Department of Medicinal Chemistry, Merck Research Laboratories, San Diego, CA 92121, USA. essa_hu@merck.com
Chua
Peter C
PC
Tehrani
Lida
L
Nagasawa
Johnny Y
JY
Pinkerton
Anthony B
AB
Rowe
Blake A
BA
Vernier
Jean-Michel
JM
Hutchinson
John H
JH
Cosford
Nicholas D P
ND
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000814:Aniline Compounds; D011743:Pyrimidines; D018094:Receptors, Metabotropic Glutamate; D013449:Sulfonamides; C108822:metabotropic glutamate receptor 2