Affinity mass spectrometry from a tailored porous silicon surface.
The development of chemically stable porous silicon (pSi) materials for DIOS (Desorption/Ionization on Silicon) mass spectrometry, covalent linkers cleaved in the DIOS laser pulse, and efficient methods for bond formation to immobilized species, allows for on-chip affinity purification and mass detection.
Meng
Jun-Cai
JC
Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Siuzdak
Gary
G
Finn
M G
MG
D016062:Porosity; D011506:Proteins / Q000032:analysis; D012825:Silicon / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013499:Surface Properties
D011506:Proteins; D012825:Silicon