Polymorphisms in the 5alpha reductase type 2 gene and urologic measures of BPH.
BACKGROUND
The objective of the study was to examine associations between SRD5A2 polymorphisms and measures of benign prostatic hyperplasia (BPH).


METHODS
Participants were 510 Caucasian men (median age 60 years), randomly selected from the Olmsted County, MN community to participate in a longitudinal study of BPH. From 1990 through 2000, biennial measurements of lower urinary tract symptom severity (assessed from the American Urological Association Symptom Index, AUASI), peak urinary flow rates (Qmax), and prostate volume were made. Genotyping of SRD5A2 V89L, A49T, and TA repeat polymorphisms were performed.


RESULTS
Compared with the VV genotype, the LL genotype was associated with an enlarged prostate (Hazard ratio (HR)=1.62, 95% confidence interval (CI)=1.06, 2.43) but not with AUASI, Qmax, or PSA. The A49T and TA repeat polymorphisms were not associated with BPH. When the LL/VL, AT/TT, and TA0/TA0 genotypes were considered high risk, the number of high risk genotypes increased with increasing prostate volume (32.3, 30.7, 34.1, and 38.7, respectively, P for trend=0.04).


CONCLUSIONS
These findings do not demonstrate consistent associations between SRD5A2 genotypes and BPH. However, they suggest that the associations of V89L polymorphisms and prostate volume should be investigated further.
Roberts
Rosebud O
RO
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. roberts.rosebud@mayo.edu
Bergstralh
Erik J
EJ
Farmer
Sara A
SA
Jacobson
Debra J
DJ
McGree
Michaela E
ME
Hebbring
Scott J
SJ
Cunningham
Julie M
JM
Anderson
Sarah A
SA
Thibodeau
Stephen N
SN
Lieber
Michael M
MM
Jacobsen
Steven J
SJ
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000235:genetics*; D000328:Adult; D000368:Aged; D000375:Aging; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000473:pathology*; D012720:Severity of Illness Index; D014555:Urination Disorders / Q000209:etiology
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase