Inroads into base excision repair I. The discovery of apurinic/apyrimidinic (AP) endonuclease. "An endonuclease for depurinated DNA in Escherichia coli B," Canadian Journal of Biochemistry, 1972.
DNA treated with alkylating agents is incised at sites of damage by cell extracts. A key component of this DNA repair function was shown by Verly and co-workers to be an endonuclease acting at secondary lesions, apurinic sites, rather than directly at alkylated nucleotide residues.
Lindahl
Tomas
T
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK. Tomas.Lindahl@cancer.org.uk
Verly
W G
WG
Paquette Y
D004260:DNA Repair; D004269:DNA, Bacterial / Q000266:history; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000266:history*; D004926:Escherichia coli / Q000201:enzymology*; D049673:History, 20th Century
D004269:DNA, Bacterial; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase