Reproducibility of fMRI at 1.5 T in a strictly controlled motor task.
Reproducibility of functional MRI (fMRI) data has been controversial. This issue was examined in this study by evaluating a strictly controlled voluntary force-matching handgrip task. Handgrip force, electromyogram (EMG), and fMRI data of brain activity were simultaneously recorded during the task performance. The task was repeated three times in each of the two experimental sessions. While force remained unchanged and EMG showed little variation across trials and sessions, the results revealed that fMRI-measured brain signals varied significantly among individual trials. However, the averaged fMRI signals over the three trials did not show significant difference between the two sessions. Our data suggest that fMRI is better at defining brain activation qualitatively than quantitatively, i.e., the locations of the activation areas could be reproduced quite reliably while their sizes fluctuated substantially.
Liu
Jing Z
JZ
Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. liuj@bme.ri.ccf.org
Zhang
Luduan
L
Brown
Robert W
RW
Yue
Guang H
GH
D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D004576:Electromyography; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D015203:Reproducibility of Results