title: Inroads into base excision repair I. The discovery of apurinic/apyrimidinic (AP) endonuclease. "An endonuclease for depurinated DNA in Escherichia coli B," Canadian Journal of Biochemistry, 1972.
abstract: DNA treated with alkylating agents is incised at sites of damage by cell extracts. A key component of this DNA repair function was shown by Verly and co-workers to be an endonuclease acting at secondary lesions, apurinic sites, rather than directly at alkylated nucleotide residues.
authors.affiliation: Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK. Tomas.Lindahl@cancer.org.uk
authors.forename: Tomas
authors.initials: T
authors.lastname: Lindahl
authors.forename: W G
authors.initials: WG
authors.lastname: Verly
authors.lastname: Paquette Y
mesh_terms: D004260:DNA Repair; D004269:DNA, Bacterial / Q000266:history; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000266:history*; D004926:Escherichia coli / Q000201:enzymology*; D049673:History, 20th Century
chemical_list: D004269:DNA, Bacterial; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase