title: Apolipoprotein Eepsilon4 allele, a risk factor for late onset nonfamilial Alzheimer's disease among Israeli Jews.
abstract: Apolipoprotein (apoE) genotypes were determined in 90 Israeli Jews with late onset sporadic Alzheimer's Disease (AD) and in 90 age- and sex-matched non-demented controls. The percentage of subjects carrying at least one apoEepsilon4 allele was 6% among the controls, and 42% among the patients (P<0.001), indicating a strong association between late onset sporadic AD and the apoEepsilon4 allele. However, no association was found between the apoEepsilon4 allele in demented and non-demented Jewish Israeli patients with Down's syndrome or Creutzfeldt-Jakob disease (CJD). The data presented in this paper confirmed several recent reports, suggesting that the apoEepsilon4 allele is a risk factor for the development of AD but not for the development of CJD or Down's syndrome among Israeli Jews.
authors.affiliation: Division of Medicine, Geriatric Unit, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Friedman
authors.forename: R
authors.initials: R
authors.lastname: Gabizon
authors.forename: A
authors.initials: A
authors.lastname: Ben-Yehuda