[Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphosarcoma].
OBJECTIVE
Efficacy of the treatment of primary mediastinal B-cell lymphosarcoma depends to a great extent on early diagnosis and treatment policy. In this study we evaluated possibilities of diagnosis and treatment of thrombotic complications of primary mediastinal B-cell lymphosarcoma (PMBL).


METHODS
61 patients were examined using roentgenography, computed tomography, chest ultrasound investigation,coagulogram, allelle specific polymerase chain reaction, ultrasound investigation of the jugular, subclavian, brachial veins, vena cava superior to detect mutation of genes II, V factors and methylentetrahydrofolatereductase.


RESULTS
In 7 cases prechemotherapy examination detected thrombosis of the internal jugular and subclavian veins. In 4 of 7 cases there was a combined thrombosis of the left internal jugular and subclavian veins, in 3 cases one the vessels was affected with thrombosis. In 2 cases, in the course of polychemotherapy, there was recurrent thrombosis and development of pulmonary artery thromboembolism (PATE). In progression of the disease there was thrombosis of the left subclavian vein (1 case) and PATE (a case). Coagulologically, hypercoagulation syndrome signs were registered. 5 patients with PMBL complicated by thromboses showed gene mutations.


CONCLUSIONS
In PMBL there is a tendency to formation of venous thrombosis and development of PATE. This is explained by tumor process and hereditary factors of thrombogenicity. Therefore, specific antitumor treatment should include anticoagulation therapy.
Dzhumabaeva
B T
BT
Kremenetskaia
A M
AM
Vasil'ev
S A
SA
Shulutko
E M
EM
Kravchenko
S K
SK
Shevelev
A A
AA
Sergeeva
E V
EV
Sakhibov
Ia D
IaD
Orel
E B
EB
Romanova
E A
EA
Frank
G A
GA
D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000097:blood / Q000150:complications* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D008479:Mediastinal Neoplasms / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome
D000925:Anticoagulants
Vozmozhnosti diagnostiki i lecheniia tromboticheskikh oslozhneniĭ pri pervichnoĭ mediastenal'noĭ B-kletochnoĭ limfosarkome.