Trisomy 4 and ring chromosome in a patient with acute myelomonocytic leukemia.
We describe a patient with acute myelomonocytic leukemia (AMML) in whom cytogenetic analysis revealed trisomy 4 associated with a ring chromosome. In addition, in a cytogenetically unrelated clone, trisomy 8 and 5q- abnormalities were detectable. The possibility of a subclinical myelodysplastic syndrome preceding the onset of AML is discussed on the basis of the morphological and cytogenetic findings.
Vicari
L
L
Medical Genetics Service, Cardarelli Hospital, Naples, Italy.
Sebastio
L
L
Stanziola
M C
MC
Fasanaro
A
A
Ferrara
F
F
D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002872:Chromosome Deletion; D002894:Chromosomes, Human, Pair 4; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure; D002898:Chromosomes, Human, Pair 8; D002999:Clone Cells / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology; D011289:Preleukemia / Q000235:genetics / Q000473:pathology; D012303:Ring Chromosomes; D014314:Trisomy