title: Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios.
abstract: The glutamate pathways are involved in diverse processes such as learning and memory, epilepsy, and they play important roles in neural plasticity, neural development, and neurodegeneration. It has been proposed that autism could be a hypoglutamatergic disorder. Recently, Jamain et al. reported that the glutamate receptor 6 (GluR6 or GRIK2) is in linkage disequilibrium with autism. In the present study, the transmission disequilibrium test (TDT) and the haplotype transmission were performed to analyze the four SNPs (SNP1: rs995640; SNP2: rs2227281; SNP3: rs2227283; SNP4: rs2235076) of GluR6 in 174 Chinese Han parent-offspring trios. The TDT demonstrated that the two SNPs (SNP2 and SNP3) showed preferential transmission (TDT P = 0.032). The global chi(2) test for haplotype transmission also revealed an association between GluR6 and autism (chi(2) = 10.78, df = 3, P = 0.013). Our results suggested that GluR6 is in linkage disequilibrium with autism.
authors.affiliation: Institute of Mental Health, Peking University, Beijing, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Shuang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Mei Xiang
authors.initials: MX
authors.lastname: Jia
authors.forename: Jian Zhong
authors.initials: JZ
authors.lastname: Yang
authors.forename: Su Ping
authors.initials: SP
authors.lastname: Wu
authors.forename: Xiao Hong
authors.initials: XH
authors.lastname: Gong
authors.forename: Yan Su
authors.initials: YS
authors.lastname: Ling
authors.forename: Yan
authors.initials: Y
authors.lastname: Ruan
authors.forename: Xiao Ling
authors.initials: XL
authors.lastname: Yang
authors.forename: Dai
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D001321:Autistic Disorder / Q000235:genetics*; D002681:China; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009679:Nuclear Family; D020641:Polymorphism, Single Nucleotide; D018092:Kainic Acid Receptors / Q000235:genetics*; D000097806:GluK2 Kainate Receptor
chemical_list: D018092:Kainic Acid Receptors; D000097806:GluK2 Kainate Receptor