Preparation and enantioseparation characteristics of two chiral stationary phases based on mono(6(A)-azido-6(A)-deoxy)-perphenylcarbamoylated alpha- and gamma-cyclodextrin.
Two chiral stationary phases, ph-alpha-CD and ph-gamma-CD, were prepared from mono(6(A)-azido-6(A)-deoxy)perphenylcarbamoylated alpha- and gamma-cyclodextrin immobilized onto silica gel via the Staudinger reaction. The chromatographic characteristics of these two chiral stationary phases were evaluated. The influence of different cyclodextrins (CDs) on the enantioselectivities was also investigated in this study. Compared to ph-gamma-CD, ph-alpha-CD exhibited quite good enantioselectivity toward the analytes with bulky molecular structures. It was found that the formation of inclusion complex might play a quite important role in the chiral recognition not only under reverse phases but also under normal phases.
Lai
Xiang-Hua
XH
Department of Chemistry, National University of Singapore, Singapore.
Bai
Zheng-Wu
ZW
Ng
Siu-Choon
SC
Ching
Chi-Bun
CB