title: Changes of antimicrobial resistance and extended-spectrum beta-lactamase production in Klebsiella spp. strains.
abstract: Changes of antimicrobial resistance and extended-spectrum beta-lactamase (ESBL) production of Klebsiella spp. strains isolated at the Central Military Hospital, Ruzomberok, Slovakia, with a special focus on the Anesthesiology--Resuscitation and Intensive Medicine Department during the years 1998-2002, were analyzed. Of 3920 gram-negative strains isolated from clinical materials during this period, Klebsiella spp. represented 8%. The incidence of ESBL-producing Klebsiella spp. isolates increased from 29% in 1998 to 69% in 2002. Of 17 antibiotics tested, meropenem was found to be the most effective drug (100%). The overall efficacy of cefotaxime was 31%, that of gentamicin 23%, and that of ciprofloxacin 54%. Analyzed Klebsiella isolates were characterized also by a high degree of multiresistance (53%). The high incidence of reduced antibiotic susceptibility among Klebsiella spp. strains isolated at the intensive-care department suggests that more effective strategies are necessary to control the selection and spread of resistant organisms in this hospital.
authors.affiliation: Department of Clinical Microbiology, Central Military Hospital, 034 26 Ruzomberok, Slovakia. timkoj@uvn.sk
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Timko
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006772:Hospitals, Military; D006801:Humans; D007362:Intensive Care Units; D007709:Klebsiella / Q000145:classification / Q000187:drug effects*; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D018154:Slovakia / Q000453:epidemiology; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases