Cytokines in the central nervous system: targets for therapeutic intervention.
Accumulating evidence implicates inflammatory processes in the development of a number of neurodegenerative diseases and demonstrates that neurons and microglia can be a source for various cytokines, which are believed to be involved in neuropathology, and therefore can serve as targets for therapeutic treatment. Moreover, it is now established that many of these pro-inflammatory molecules, commonly associated with the peripheral immune system, are also produced within the central nervous system (CNS). The term 'cytokine network' has been widely used to describe cytokine biology in the brain. However, the function of this network has not been well-characterised. It is believed that understanding the function of this network might have important clinical applications. This article reviews recent and current developments in cytokine research that pertain to the development of new strategies targeting cytokines in the brain, thus opening up new avenues for novel therapeutic approaches for the treatment of various pathological conditions and diseases of the CNS.
Safieh-Garabedian
Bared
B
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, 1107-2020, Lebanon. bared@aub.edu.lb
Haddad
John J
JJ
Saadé
Nayef E
NE
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D002490:Central Nervous System / Q000187:drug effects / Q000276:immunology* / Q000503:physiopathology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000276:immunology*; D004660:Encephalitis / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000639:trends; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000276:immunology*; D017628:Microglia / Q000187:drug effects / Q000276:immunology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D018836:Inflammation Mediators