title: Complete replacement of H2 by D2 via Pd/C-catalyzed H/D exchange reaction.
abstract: [reaction: see text] A general and in situ D2 gas generation method using 10% Pd/C-catalyzed H2-D2 exchange reaction in a H2-D2O system has been developed. H2 gas sealed in a reaction flask was efficiently converted into nearly pure D2 gas, which can be used for the reductive deuteration of substrates possessing reducible functionalities within the molecule.
authors.affiliation: Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. sajiki@gifu-pu.ac.jp
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
authors.forename: Takanori
authors.initials: T
authors.lastname: Kurita
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Esaki
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Aoki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maegawa
authors.forename: Kosaku
authors.initials: K
authors.lastname: Hirota