Treatment of relapses in aggressive non Hodgkin's lymphoma.
In spite of considerable progress in the initial treatment of aggressive non Hodgkin's lymphoma, patients in relapse have poor prognosis. Patients with refractory disease have an even worse outcome. Current strategies and published reports of relapsing patients are presented. Intensification of chemosensitive relapse has yielded a number of continuous second remissions. However considerable efforts are required to define when transplantation should be performed, which type of graft should be used, and what type of post-intensification therapy can be proposed to improve the remission rate and duration.
Bosly
André
A
Université Catholique de Louvain, Department of Hematology, Mont-Godinne University Hospital, 5530 Yvoir, BELGIUM.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000628:therapy*; D012074:Remission Induction; D016879:Salvage Therapy / Q000379:methods*; D055502:Secondary Prevention