Management of infertility and prevention of ovarian hyperstimulation in women with polycystic ovary syndrome.
Anovulatory infertility is a prevalent presenting feature of polycystic ovary syndrome (PCOS). Restoration of ovulation might be achieved by ovarian stimulation or by reducing insulin and LH concentrations. Clomiphene citrate is the first-line ovulation-inducing agent, usually followed by direct stimulation with follicle stimulating hormone (FSH), if unsuccessful. The prevalent complications of ovarian hyperstimulation syndrome and multiple pregnancies can largely be avoided by administering FSH in a low dose and individualized regimen. Hyperinsulinaemia can be corrected by weight loss or insulin-sensitizing agents, such as metformin, which alone or in combination with other agents are capable of restoring ovulation. Advice about weight loss is critical in modern management of PCOS and infertility. Laparoscopic ovarian drilling produces similar results to FSH stimulation, and in vitro fertilization/embryo transfer (IVF/ET)-if all else fails-produces excellent results. The possible use of aromatase inhibitors, novel insulin sensitizers and in vitro maturation of oocytes is still being evaluated. The plethora of treatment options available today ensures that the great majority of women who are subfertile due to PCOS can be treated successfully.
Homburg
Roy
R
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Vrije Universiteit Medisch Centrum, De Boelelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands. r.homburg@vumc.nl
D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D006946:Hyperinsulinism / Q000188:drug therapy; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D015431:Weight Loss
D005300:Fertility Agents, Female; D002996:Clomiphene