Evaluation of alternative calculation methods for determining low-density lipoprotein cholesterol in hemodialysis patients.
OBJECTIVE
To evaluate alternative equations for the estimation of low-density lipoprotein cholesterol (LDL-C) than the Friedewald equation in hemodialysis patients.


METHODS
The equations LDL-C = 0.41TC - 0.14TG + 0.66ApoB - 10.43 and LDL-C = 0.94TC - 0.94HDL-C - 0.19TG were evaluated in 86 patients and compared with the Friedewald equation and the ultracentrifugation procedure.


RESULTS
The alternative equations yield significantly lower bias than the Friedewald equation and are less affected by increased triglycerides (TG) levels.


CONCLUSIONS
The alternative equations for LDL-C yield slightly better results than the Friedewald equation especially in hypertriglyceridemia.
Bairaktari
Eleni T
ET
Laboratory of Biochemistry, University Hospital, Medical School, University of Ioannina, 451 10, Ioannina, Greece. ebairakt@cc.uoi.gr
Tzallas
Christos
C
Kalientzidou
M
M
Tselepis
Alexandros D
AD
Siamopoulos
Kostas C
KC
Seferiadis
Konstantin I
KI
Elisaf
Moses S
MS
D000328:Adult; D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D006435:Renal Dialysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014280:Triglycerides / Q000097:blood; D014461:Ultracentrifugation
D008078:Cholesterol, LDL; D011933:Reagent Kits, Diagnostic; D014280:Triglycerides