Expression of cell cycle-dependent genes and proliferative state of lymphocytes in aging.
The authors analyzed the expression of some genes involved in the control of T lymphocyte proliferation in a group of healthy elderly subjects. They focused their attention on genes involved in the G(0)/G(1) transition (TK, PCNA, H3, IL2-R) and showed decreased expression in the TK, H3 and IL2-R genes. Using flow cytofluorimetry, delayed transition from the G(0)/G(1) to the S stage was observed.
Travali
S
S
Istituto di Patologia Generale, Università di Catania, Catania, Italy.
Carnazzo
G
G
Distefano
A M
AM
Manciagli
P
P
Cosenza
C
C
Fidone
E
E
Petralia
S
S
Bernardini
A
A
Motta
L
L
Stivala
F
F