[The chromosomal location of AD7C-NTP gene and the prediction of transmembrane domains of its deduced protein].
OBJECTIVE
To characterize the chromosomal location of AD7C-NTP gene and predict the transmembrane domains and sub-cellular location of its deduced protein.


METHODS
The AD7C-NTP mRNA sequence was alignmented with human genomic DNA sequence by Blat server. The transmembrane domains and sub-cellular location of AD7C-NTP protein were predicted by using PHDhtm, TMHMM2.0, HMMTOP2.0, SMART and PSORT servers, etc.


RESULTS
The AD7C-NTP gene located in minus strand of 1p36.11, without intron. The AD7C-NTP protein was predicted to have 3 potential transmembrane domains and locate on peroxisome's membrane.


CONCLUSIONS
Bioinformatics analysis of the AD7C-NTP gene and its deduced protein provides valuable clues for further gene cloning and study of function.
Gui
Jun-hao
JH
Clinical Medical Research Institute, Urumqi General Hospital, Lanzhou Command of PLA, Urumqi 830000, China. guijunhao@163.net
Liu
Jia-yun
JY
Jia
Lin-tao
LT
Chou
Dong-hui
DH
Yu
Wu-zhong
WZ
He
Jiang
J
D000544:Alzheimer Disease / Q000235:genetics*; D000595:Amino Acid Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D019295:Computational Biology / Q000379:methods; D018076:DNA, Complementary / Q000235:genetics; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D016571:Neural Networks, Computer; D020675:Peroxisomes / Q000235:genetics* / Q000378:metabolism; D011446:Prospective Studies; D012333:RNA, Messenger / Q000235:genetics; D016415:Sequence Alignment
C109804:AD7c-NTP; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger