title: Cortical regulation during the early stage of initiation of voluntary swallowing in humans.
abstract: The aim of the present study was to reveal the spatiotemporal relations among cortical regions involved in the initiation of voluntary swallowing in humans using magnetoencephalography (MEG). As a control task, finger extension movement, which is purely voluntary, was also investigated using the same techniques. The swallowing-related activity was distributed widely for 2000 ms before the electromyogram onset of the right suprahyoid muscle; however, the finger-related activity occurred in the late stage of the recording. The cingulate cortex, the insula, and the inferior frontal gyrus were the main loci active prior to swallowing. These cortical loci coincide with those suggested by previous human brain mapping studies that investigated the brain mechanism which controls swallowing. Activation in the cingulate cortex was registered in the early stage of swallowing and could be related to the cognitive process regarding the food being safe to swallow. The activation in the insula lasted for a long time before the initiation of swallowing. This suggests that the long-lasting activation in the insula prior to swallowing is essential for the initiation of swallowing.
authors.affiliation: Department of Oral Medicine, Tokyo Dental College, Ichikawa General Hospital, Ichikawa-city, Chiba, Japan. ywata@tdc.ac.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Shinichi
authors.initials: S
authors.lastname: Abe
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yamada
authors.forename: Gen-yuki
authors.initials: GY
authors.lastname: Yamane
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000502:physiology*; D003679:Deglutition / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D013997:Time Factors