A new approach to bioconjugates for proteins and peptides ("pegylation") utilising living radical polymerisation.
The synthesis of protein-polymer bioconjugates is reported using N-succinimidyl ester functionalised polymers from transition metal mediated living radical polymerisation.
Lecolley
François
F
Department of Chemistry, University of Warwick, Coventry, UKCV4 7AL.
Tao
Lei
L
Mantovani
Giuseppe
G
Durkin
Ian
I
Lautru
Sylvie
S
Haddleton
David M
DM
D000179:Acrylates / Q000737:chemistry*; D002021:Buffers; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D008689:Methacrylates; D010455:Peptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*
D000179:Acrylates; D002021:Buffers; D008689:Methacrylates; D010455:Peptides; D011506:Proteins; D013388:Succinimides; C421283:poly(ethylene glycol)-dimethacrylate; D011092:Polyethylene Glycols