title: On-chip high-pressure picoliter injector for pressure-driven flow through porous media.
abstract: A high-pressure (> 3 MPa) on-chip injector has been developed for microchip applications including HPLC. The mechanical injector is implemented using in situ photopolymerization of fluorinated acrylates inside wet-etched silica microchips. The injector allows reproducible injections as small as 180 pL with < 250 ms duration. The injector operated robustly over 60 days and over 1000 injections. The injector is unique among polymer-based valves as it functions in aqueous, acetonitrile, and mixed buffers at high pressures without detectable leakage.
authors.affiliation: Sandia National Laboratories, Livermore, California, P.O. Box 969 MS 9951, Livermore, California 94551, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Reichmuth
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Shepodd
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Kirby
mesh_terms: D000179:Acrylates / Q000737:chemistry; D002021:Buffers; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D005465:Fluorocarbon Polymers / Q000737:chemistry; D006874:Hydrostatic Pressure; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D010777:Photochemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000179:Acrylates; D002021:Buffers; D005465:Fluorocarbon Polymers; D012822:Silicon Dioxide