title: Solid-phase synthesis of second-generation polyproline dendrimers.
abstract: Second-generation dendrimers have been prepared on solid phase by successive additions of branched polyproline building blocks starting from two different branching units anchored to the solid support. The preparation of Pro-rich building blocks was carried out by stepwise solid-phase synthesis and their iterative addition was performed by a convergent approach, also using solid-phase synthesis. cis-4-Amino-L-proline and imidazolidine-2-carboxylic acid were used as branching units due to their structural resemblance to proline. The optimized strategy allowed the target compounds to be obtained with high purities without the need for purification steps.
authors.affiliation: Barcelona Biomedical Research Institute, Barcelona Science Park, University of Barcelona, Josep Samitier 1, 08028 Barcelona, Spain.
authors.forename: Glòria
authors.initials: G
authors.lastname: Sanclimens
authors.forename: Laia
authors.initials: L
authors.lastname: Crespo
authors.forename: Ernest
authors.initials: E
authors.lastname: Giralt
authors.forename: Miriam
authors.initials: M
authors.lastname: Royo
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D002851:Chromatography, High Pressure Liquid; D008722:Methods; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010455:Peptides; C011083:polyproline