title: Effective use of preparative chiral HPLC in a preclinical drug synthesis.
abstract: Access to a key 3-aryl-delta-lactone intermediate in enantiopure form using preparative chiral chromatography allowed expedited preparation of an important drug discovery target. A preclinical drug discovery strategy that combines rapid route discovery with effective use of preparative chiral chromatography can result in significant savings of both time and labor.
authors.affiliation: Department of Process Research, Merck Research Laboratories, Merck & Co., Rahway, NJ 07065, USA.
authors.forename: Todd D
authors.initials: TD
authors.lastname: Nelson
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Welch
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Rosen
authors.forename: Jacqueline H
authors.initials: JH
authors.lastname: Smitrovich
authors.forename: Mark A
authors.initials: MA
authors.lastname: Huffman
authors.forename: James M
authors.initials: JM
authors.lastname: McNamara
authors.forename: David J
authors.initials: DJ
authors.lastname: Mathre
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D025924:Chromatography, Supercritical Fluid; D015195:Drug Design; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D004952:Esters; D007202:Indicators and Reagents; D007783:Lactones; D004364:Pharmaceutical Preparations