Involvement of immunoglobulin FcgammaRIIA and FcgammaRIIIB gene polymorphisms in susceptibility to rheumatic fever.
OBJECTIVE
To assess the impact of the human FcgammaRIIA and FcgammaRIIIB gene polymorphisms on the risk of rheumatic fever (RF).


METHODS
FcgammaRIIA-R/H-131 and FcgammaRIIIB-NA1/NA2 genotypes were determined using polymerase chain reaction in 66 RF cases and 117 healthy controls in this case control study.


RESULTS
Compared with healthy controls, the RR genotype was enriched in the entire group of RF cases (odds ratio [OR] 4.98, 95% confidence interval [95% CI] 1.81-13.70). RF patients were more frequently HR heterozygotes rather than HH homozygotes (OR 3.09 vs. 0.11). The results of this study show that patients who have RF are more likely to have the RR and HR genotypes than control children. These probabilities show that RR is associated with the greatest risk for rheumatic fever and HR is associated with an intermediate risk. For the distribution of FcgammaRIIIB NA2 genotypes, a nonsignificant increase was found in RF patients (39.31% vs. 51.51%; OR 1.64, P = 0.1226).


CONCLUSIONS
The FcgammaRIIA-R/H-131 polymorphism may be an important marker in determining predisposition to RF.
Berdeli
Afig
A
Laboratory of Molecular Medicine, Department of Pediatrics, Ege University School of Medicine, Bornova, 35100 Izmir, Turkey. afig@med.ege.edu.tr
Celik
Handan Ak
HA
Ozyürek
Ruhi
R
Aydin
Hikmet Hakan
HH
D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D058851:GPI-Linked Proteins; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012213:Rheumatic Fever / Q000235:genetics* / Q000276:immunology; D014421:Turkey
D015703:Antigens, CD; C428200:FCGR3B protein, human; C080568:Fc gamma receptor IIA; D058851:GPI-Linked Proteins; D017452:Receptors, IgG