Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes.
Type I diabetes is a complex disease in which multiple susceptibility loci have been implicated by whole genome scans. IDDM8, a susceptibility locus, is located on chromosome 6q27, however the specific susceptibility gene has yet to be identified. We have examined five potential candidate genes using 36 genetic markers, spanning 360kb located near the chromosome 6q27 terminus in 478 families for diabetes association. No associations with type I diabetes susceptibility were detected with the strength previously observed for IDDM1 or IDDM2. However, a novel CAG/CAA polymorphism was detected in exon 3 of the TATA box-binding protein gene, which shows preliminary evidence of association with diabetes susceptibility (p<0.05).
Owerbach
David
D
Molecular Diabetes and Metabolism Section, Department of Pediatrics, Harry B. and Aileen B. Gordon Diabetes Research Center, Baylor College of Medicine, Houston, TX 77030, USA. davido@bcm.tmc.edu
Piña
Lazaro
L
Gabbay
Kenneth H
KH
D002874:Chromosome Mapping / Q000379:methods*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012189:Retrospective Studies; D035181:TATA-Box Binding Protein / Q000235:genetics*
D005819:Genetic Markers; D035181:TATA-Box Binding Protein