Reconsidering idiopathic CK-elevation.
This study investigated the frequency of persisting, idiopathic creatine-kinase (CK)-elevation, how often the cause of idiopathic CK-elevation could be clarified, and the most frequent causes of idiopathic CK-elevation. Among 28 patients with previously idiopathic CK-elevation, CK remained elevated in 32%. The cause of idiopathic CK-elevation could be determined in 46%. Causes were mitochondriopathy (n = 5), seizure (n = 2), stroke (n = 2), myositis (n = 1), intramuscular-injection (n = 1), alcohol myopathy (n = 1), and pravastátin myopathy (n = 1). In 10 of these patients CK was normal at follow-up. CK-elevation remained idiopathic in 54%. Idiopathic CK-elevation should be comprehensively re-evaluated, even if CK is only slightly elevated or normal at follow-up.
Finsterer
Josef
J
Neurological Hospital Rosenhügel, Vienna, Austria. duarte@aonmail.at
Neuhuber
Werner
W
Mittendorfer
Bettina
B
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000201:enzymology*; D011446:Prospective Studies; D012016:Reference Values; D012189:Retrospective Studies; D012640:Seizures / Q000201:enzymology
D007527:Isoenzymes; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form