title: Enantioselective alkylation of beta-keto esters by phase-transfer catalysis using chiral quaternary ammonium salts.
abstract: Catalytic enantioselective alkylation promoted by a quaternary ammonium salt from cinchonine as a phase transfer catalyst is described. Treatment of cyclo beta-keto esters with alkyl halide under mild reaction conditions afforded the corresponding alpha-alkylated beta-keto esters in moderate to excellent yields with high enantiomeric excesses
authors.affiliation: Department of Chemistry, Soonchunhyang University, Asan P.O. Box 97, Chungnam 336-600, Korea.
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Park
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Kim
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kim