title: Community-based study in Taiwan aborigines concerning renal dysfunction in gout patients.
abstract: OBJECTIVE
  To reveal the factors associated with renal dysfunction among gout patients in Taiwan aborigines.
  
  
  METHODS
  Social demographic data, alcohol consumption data, anthropometric measurements, blood samples, and 24-h urine samples were collected from 128 aboriginals (101 men, 27 women) suffering from gout.
  
  
  RESULTS
  The men displayed higher mean creatinine clearance (Ccr) values than women. Twenty-two post-menopausal women had significantly lower Ccr values compared to the five pre-menopausal women [probability (p)<0.001]. The males displayed higher 24-h urinary creatinine value than females (8.60+/-5.39 versus 5.58+/-2.14 mmol/L; p<0.05), and showed a significantly higher positive relationship between 24-h urinary creatinine and uric acid excretion [correlation coefficient (r)=0.7304; p<0.001], whereas the females did not (r=0.1144; p=0.5691). Overall, those who were older members of the Tsou tribe, or had excreted less uric acid from urine in 24 h tended to suffer renal dysfunction.
  
  
  CONCLUSIONS
  Gout patients displayed diversity in renal function. An exogenous source of creatinine in men was more likely than in women.
authors.affiliation: Department of Public Health, School of Medicine, Kaohsiung Medical University, Taiwan.
authors.forename: S J
authors.initials: SJ
authors.lastname: Chang
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
authors.forename: H P
authors.initials: HP
authors.lastname: Hung
authors.forename: T T
authors.initials: TT
authors.lastname: Ou
authors.forename: Y C
authors.initials: YC
authors.lastname: Ko
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006073:Gout / Q000150:complications* / Q000208:ethnology*; D006306:Health Surveys; D006801:Humans; D007674:Kidney Diseases / Q000208:ethnology* / Q000209:etiology*; D008297:Male; D008593:Menopause; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D013624:Taiwan
chemical_list: D003404:Creatinine