title: Perfusion technique for nonhaemic cardiopulmonary bypass prime in neonates and infants under 6 kg body weight.
abstract: BACKGROUND
  Cardiopulmonary bypass (CPB) in neonates and infants is associated with significant haemodilution when priming of the CPB circuit is accomplished without transfusion of homologous blood components. The degree of haemodilution and, thus, the requirements for blood transfusion may be reduced when the CPB circuit is miniaturized without compromising patient safety.
  
  
  METHODS
  Between January 2002 and October 2003, selected neonates and small infants were operated on using a nonhaemic prime extracorporeal circuit. CPB priming volume could be reduced from 300 mL to 190 mL by using a dedicated neonatal CPB console with mast-mounted roller pump heads. Reduction of priming volume resulted from shortening of all CPB lines to the minimum, downsizing of all CPB lines, exclusion of unused CPB components, use of vacuum-assisted venous drainage and from close co-operation between the perfusionist, cardiac surgeon and anaesthesiologist. The reduction in priming volume was achieved without eliminating the arterial line filter as safety device.
  
  
  RESULTS
  A total of nine patients weighing between 3.2 and 5.9 kg (mean 4.7 kg) and with a body surface area of 0.22-0.35 m2 (mean 0.29 m2) were operated on with the use of the modified neonatal CPB circuit and a nonhaemic prime. Bypass time varied from 38 to 167 min (mean 96 min). The mean haematocrit on CPB was 22.5% with a range of 17-29%. The postoperative course of all patients was uneventful.
  
  
  CONCLUSIONS
  A significant reduction in CPB priming volume makes nonhaemic prime CPB in neonates and small infants undergoing complex repair of congenital heart defects possible.
authors.affiliation: Academy for Perfusion, Deutsches Herzzentrum Berlin, Berlin, Germany. merkle@dhzb.de
authors.forename: Frank
authors.initials: F
authors.lastname: Merkle
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Boettcher
authors.forename: Fritz
authors.initials: F
authors.lastname: Schulz
authors.forename: Andreas
authors.initials: A
authors.lastname: Koster
authors.forename: Michael
authors.initials: M
authors.lastname: Huebler
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
mesh_terms: D001804:Blood Transfusion, Autologous; D001810:Blood Volume; D001835:Body Weight; D002315:Cardiopulmonary Bypass; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006438:Hemodilution; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015424:Reperfusion / Q000379:methods*