title: Joint hypermobility syndrome and mitral valve prolapse in panic disorder.
abstract: OBJECTIVE
  The purpose of this study is to test the association between joint hypermobility syndrome (JHS) and panic disorder (PD) and to determine whether mitral valve prolapse (MVP) modifies or accounts in part for the association.
  
  
  METHODS
  A total of 115 subjects are included in this study in three groups. Group I (n = 42): panic disorder patients with MVP. Group II (n = 35): panic disorder patients without mitral valve prolapse. Group III (n = 38): control subjects who had mitral valve prolapse without any psychiatric illness. Beighton criteria were used to assess joint hypermobility syndrome. Two-dimensional and M-mode echocardiography was performed on each subject to detect mitral valve prolapse.
  
  
  RESULTS
  Joint hypermobility syndrome was found in 59.5% of panic disorder patients with mitral valve prolapse, in 42.9% of patients without mitral valve prolapse and in 52.6% of control subjects. Beighton scores was 4.93 +/- 2.97 in group I, 4.09 +/- 2.33 in group II, and 4.08 +/- 2.34 in group III. There was no significant difference between groups according to Beighton scores.
  
  
  CONCLUSIONS
  We did not detect a statistically significant relationship between panic disorder and joint hypermobility syndrome. Mitral valve prolapse and joint hypermobility syndrome are known to be etiologically related and we suggest that mitral valve prolapse affects the prevalence of joint hypermobility syndrome in the panic disorder patients.
authors.affiliation: Department of Psychiatry, Atatürk Education and Research Hospital, Basin Sitesi, Izmir, Turkey. drdemetgulpek@hotmail.com
authors.forename: Demet
authors.initials: D
authors.lastname: Gulpek
authors.forename: Erhan
authors.initials: E
authors.lastname: Bayraktar
authors.forename: Sebnem Pirildar
authors.initials: SP
authors.lastname: Akbay
authors.forename: Kazým
authors.initials: K
authors.lastname: Capaci
authors.forename: Meral
authors.initials: M
authors.lastname: Kayikcioglu
authors.forename: Emil
authors.initials: E
authors.lastname: Aliyev
authors.forename: Cahide
authors.initials: C
authors.lastname: Soydas
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D007593:Joint Instability / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008945:Mitral Valve Prolapse / Q000453:epidemiology / Q000209:etiology*; D016584:Panic Disorder / Q000150:complications* / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales