Neutrophil-derived S100A12 is profoundly upregulated in the early stage of acute Kawasaki disease.
Neutrophil-derived S100A12 is strongly upregulated during the acute stage of Kawasaki disease and decreases significantly in response to intravenous immune globulin (IVIG) treatment, whereas in nonresponders, serum concentrations increases after initial treatment. Decreased S100A12 expression in neutrophils was detected initially in nonresponders but increased significantly after IVIG treatment, suggesting delayed inflammatory response of neutrophils in nonresponders. Furthermore, in vitro S100A12 secretion increased with tumor necrosis factor-alpha (TNF-alpha) stimulation, whereas intracellular levels were lower in neutrophils with the higher TNF-alpha dose, suggesting intracellular depletion. S100A12 expression in neutrophils appears to reflect responsiveness to IVIG treatment and is possibly involved in the pathophysiology of acute vasculitis.
Ye
Fei
F
Department of Pediatrics, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0134, Japan.
Foell
Dirk
D
Hirono
Kei-ich
KI
Vogl
Thomas
T
Rui
Chen
C
Yu
Xianyi
X
Watanabe
Sayaka
S
Watanabe
Kazuhiro
K
Uese
Kei-ichiro
K
Hashimoto
Ikuo
I
Roth
Johannes
J
Ichida
Fukiko
F
Miyawaki
Toshio
T
D000208:Acute Disease; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D009418:S100 Proteins / Q000097:blood*; D000067616:S100A12 Protein; D015854:Up-Regulation
D015415:Biomarkers; D016756:Immunoglobulins, Intravenous; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human