Antifungal therapy of murine Aspergillus terreus infection.
Aspergillus terreus is a species which is being seen increasingly frequently and which is highly resistant to amphotericin B in vitro and clinically. We evaluated amphotericin B, caspofungin, and posaconazole in a murine model of acute invasive aspergillosis. Caspofungin and posaconazole both appeared beneficial and may be reasonable treatment alternatives for infection with A. terreus.
Graybill
John R
JR
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases (mail code 7881), 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, USA.
Hernandez
Steve
S
Bocanegra
Rosie
R
Najvar
Laura K
LK
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009503:Neutropenia / Q000188:drug therapy; D013534:Survival
D000935:Antifungal Agents