title: Pathological changes in the liver of a senescence accelerated mouse strain (SAMP8): a mouse model for the study of liver diseases.
abstract: Liver disease is characterized by fatty liver, hepatitis, fibrosis and cirrhosis and is a major cause of illness and death worldwide. The prevalence of liver diseases highlights the need for animal models for research on the mechanism of disease pathogenesis and efficient and cost-effective treatments. Here we show that a senescence-accelerated mouse strain (SAMP8 mice), displays severe liver pathology, which is not seen in senescence-resistant mice (SAMR1). The livers of SAMP8 mice show fatty degeneration, hepatocyte death, fibrosis, cirrhotic changes, inflammatory mononuclear cell infiltration and sporadic neoplastic changes. SAMP8 mice also show abnormal liver function tests: significantly increased levels of alanine amino-transferase (ALT) and aspartate aminotransferase (AST). Furthermore, titers of murine leukemia virus are higher in livers of SAMP8 than in those of SAMR1 mice. Our observations suggest that SAMP8 mouse strain is a valuable animal model for the study of liver diseases. The possible mechanisms of liver damage in SAMP8 mice are also discussed.
authors.affiliation: NYS/Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA. XYE@hotmail.com
authors.forename: X
authors.initials: X
authors.lastname: Ye
authors.forename: H C
authors.initials: HC
authors.lastname: Meeker
authors.forename: P B
authors.initials: PB
authors.lastname: Kozlowski
authors.forename: J
authors.initials: J
authors.lastname: Wegiel
authors.forename: K C
authors.initials: KC
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Imaki
authors.forename: R I
authors.initials: RI
authors.lastname: Carp
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004195:Disease Models, Animal; D009052:Leukemia Virus, Murine / Q000302:isolation & purification; D008099:Liver / Q000648:ultrastructure; D008107:Liver Diseases / Q000201:enzymology / Q000209:etiology / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D013045:Species Specificity
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase