Maternal colonisation with group B streptococcus and effectiveness of a culture-based protocol to prevent early-onset neonatal sepsis.
This study was conducted to find out the group B streptococcus colonisation of pregnant women in Kocaeli, Turkey. A culture plus individualised high-risk-based antibiotic prophylaxis was compared with high-risk-based approach alone. The screening of women was performed via vaginal and anal cultures for group B streptococcus (GBS). The maternal GBS colonisation rate was found to be 6.5%. All colonised women or preterm labours with unavailable culture results until delivery received prophylactic antibiotics. Neonatal colonisation rate and early-onset neonatal sepsis due to GBS was 1/200. The unscreened 900 women received prophylactic antibiotics due to a risk factor-based approach. The neonatal colonisation rate was 17/900 (p = 0.1), and the rate of early-onset neonatal sepsis was 3/900 (p = 0.6). A culture plus individualised high-risk-based antibiotic prophylaxis provided an insignificant change in neonatal colonisation and early-onset neonatal sepsis with GBS when compared with high-risk-based approach alone.
Yücesoy
G
G
Department of Obstetrics and Gynaecology, Kocaeli University, Faculty of Medicine Kocaeli, Turkey. gulserene@superonline.com
Calişkan
E
E
Karadenizli
A
A
Corakçi
A
A
Yücesoy
I
I
Hüseyinoğlu
N
N
Babaoğlu
K
K
D000328:Adult; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D018805:Sepsis / Q000517:prevention & control*; D013290:Streptococcal Infections / Q000517:prevention & control*; D013292:Streptococcus agalactiae