Usefulness of the peak velocity difference by tissue Doppler imaging technique as an effective predictor of response to cardiac resynchronization therapy.
Cardiac resynchronization therapy (CRT) improves symptoms and functional status in heart failure patients; however, current selection criteria need improvement. A novel tissue Doppler imaging parameter, the peak velocity difference (PVD), defined as the greatest difference in time to peak velocity between any of 6 left ventricular regions, may better select responders to CRT. Subjects were divided into 2 groups based on the PVD. Clinical and echocardiographic parameters significantly improved in subjects with dyssynchrony by the baseline PVD and had a better overall response to CRT.
Notabartolo
Dean
D
Division of Cardiology, The Carlyle Fraser Heart Center, Emory University School of Medicine, 550 Peachtree Street NE, Atlanta, GA 30308, USA.
Merlino
John D
JD
Smith
Andrew L
AL
DeLurgio
David B
DB
Vera
Fernando V
FV
Easley
Kirk A
KA
Martin
Randolph P
RP
León
Angel R
AR
D000368:Aged; D002304:Cardiac Pacing, Artificial; D016009:Chi-Square Distribution; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008297:Male; D018579:Patient Selection; D011237:Predictive Value of Tests; D018709:Statistics, Nonparametric