Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone-related hypercalcemia.
Ovarian tumors associated with hypercalcemia due to ectopic secretion of parathyroid hormone (PTH) are extremely rare. A 33-year-old woman presented with a pelvic mass and profound hypercalcemia accompanied by an elevated serum level of PTH. Laparotomy demonstrated a left ovarian tumor that on histological examination was a neuroendocrine carcinoma of non-small cell type admixed with a component of endometrioid adenocarcinoma. After left salpingo-oophorectomy, the serum calcium and PTH levels normalized. The cells of the neuroendocrine carcinoma were positive for neuron-specific enolase, synaptophysin, chromogranin A, and PTH. Hypercalcemia and elevated serum PTH levels recurred during tumor relapse, and the patient died of disease 6 months postoperatively. This is the eleventh case of neuroendocrine carcinoma of non-small cell type associated with surface epithelial neoplasm of the ovary, and the first such tumor to be associated with hypercalcemia.
Ohira
Satoshi
S
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. osatoshi@hsp.md.shinshu-u.ac.jp
Itoh
Kazuko
K
Shiozawa
Tanri
T
Horiuchi
Akiko
A
Ono
Kyoko
K
Takeuchi
Haruka
H
Hosoda
Waki
W
Konishi
Ikuo
I
D002118:Calcium / Q000097:blood; D018269:Carcinoma, Endometrioid / Q000378:metabolism / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D009384:Paraneoplastic Endocrine Syndromes / Q000150:complications / Q000473:pathology*; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*
D010281:Parathyroid Hormone; D002118:Calcium