Stevens Johnson syndrome in Pakistan: a ten-year survey.
OBJECTIVE
A pre-tested questionnaire-based, retrospective study to highlight the causative factors, mode of presentation, complications and outcome of patients with Stevens Johnson syndrome.


METHODS
Aga Khan University Hospital over a 10 year period.


METHODS
All case records with a diagnosis of Steven Johnson Syndrome in the period 1990 to 2000 were retrospectively reviewed. Data was retrieved on a comprehensive questionnaire. The demographic variatbles and drugs taken within the previous 21 days were noted. Date analysis was done by Epi-Info Version 6.0.


RESULTS
Of the 101 studied patient files, the most common offender was found to be the Penicillins as a group and Sulfadoxine-Pyrimethamine (Fansidar) when considering all drugs individually. Most common complications included electrolyte disturbances (13.9%) and congestive heart failure (6.9%). Mortality rate was high at 10.1%.


CONCLUSIONS
SJS was found to be a rare condition but having a mortality rate of 10.1%. As it can be induced by a large number of drugs, caution should be practiced while prescribing.
Ahmed
Y I
YI
Department of Medicine, The Aga Khan University Hospital, Karachi.
Azeem
S
S
Khan
O
O
Majid
T H
TH
Ahmed
D
D
Amin
A
A
Mahmood
A
A
Hameed
K
K
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002648:Child; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D012189:Retrospective Studies; D018805:Sepsis / Q000150:complications; D012737:Sex Factors; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D011795:Surveys and Questionnaires
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal