A peptide domain of bovine milk lactoferrin inhibits the interaction between streptococcal surface protein antigen and a salivary agglutinin peptide domain.
The peptide domain of salivary agglutinin responsible for its interaction with cell surface protein antigen (PAc) of Streptococcus mutans or bovine lactoferrin was found in the same peptide, scavenger receptor cysteine-rich domain peptide 2 (SRCRP2). Inhibition studies suggest that PAc and lactoferrin, of which residues 480 to 492 seem important, competitively bind to the SRCRP2 domain of salivary agglutinin.
Oho
Takahiko
T
Department of Preventive Dentistry, Kyushu University Faculty of Dental Sciences, Fukuoka, Japan. oho@denta.hal.kagoshima-u.ac.jp
Bikker
Floris J
FJ
Nieuw Amerongen
Arie V
AV
Groenink
Jasper
J
D000373:Agglutinins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D002135:Calcium-Binding Proteins; D002417:Cattle; D004268:DNA-Binding Proteins; D006801:Humans; D007781:Lactoferrin / Q000737:chemistry*; D008297:Male; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008892:Milk / Q000737:chemistry; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D013295:Streptococcus mutans; D025521:Tumor Suppressor Proteins
D000373:Agglutinins; D001426:Bacterial Proteins; D002135:Calcium-Binding Proteins; C108174:DMBT1 protein, human; D004268:DNA-Binding Proteins; D008562:Membrane Glycoproteins; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; C055764:S-layer proteins; D012471:Salivary Proteins and Peptides; D025521:Tumor Suppressor Proteins; D007781:Lactoferrin; D002118:Calcium