[Mechanisms of hypo and hyper alphalipoproteinemia in Chilean adults].
BACKGROUND
High density lipoprotein (HDL) cholesterol is inversely associated to atherosclerotic cardiovascular risk. Disturbances in HDL cholesterol plasma levels are frequent in the Chilean population, however the pathophysiological mechanisms are unknown.


OBJECTIVE
To evaluate the mechanisms involved in the hypo and hyper alfalipoproteinemias in Chilean subjects.


METHODS
Twenty three subjects with hyperalphalipoproteinemia and 12 with hypoalphalipoproteinemia, paired with control subjects (col-HDL between 35 and 55 mg/dl) were studied. We measured plasma lipids, subfractions and sizing of HDL particles and enzymatic activity of cholesteryl ester transfer protein (CETP), lecithtin: cholesterol acyltransferase (LCAT), lipoprotein lipase (LPL) and hepatic lipase (LH).


RESULTS
Subjects with hyperalphalipoproteinemia showed significantly higher levels of total HDL-cholesterol (70 +/- 2 vs 44 +/- 1 mg/dl), HDL 2 (30 +/- 3 vs 5 +/- 1 mg/dl), Apo A I (175 +/- 3 vs 146 +/- 4 mg/dl), lower HL activity (23.7 +/- 0.8 vs 32.4 +/- 1.8 mmol/h/l) and HDL particles of greater size, compared to their controls. Subjects with hypoalphalipoproteinemia, showed significantly lower levels of total HDL-cholesterol (26 +/- 1 vs 48 +/- 2 mg/dl), HDL 3 (21 +/- 1 vs 40 +/- 2 mg/dl), Apo A I (107 +/- 5 vs 145 +/- 7 mg/dl), lower LCAT activity (18.6 +/- 1.9 vs 26.2 +/- 1.6 nmol/h/ml) and smaller HDL particles, compared to their controls.


CONCLUSIONS
Changes in hepatic lipase and lecithin cholesterol acyltransferase activities may explain the hyper and hypo alphalipoproteinemia respectively, in Chilean subjects.
Cuevas
Ada
A
Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. acuevas@rdc.cl
Alvarez
Verónica
V
Acosta
Ana María
AM
Altayó
Marcela
M
Montero
Joaquín
J
Rigotti
Attilio
A
D000328:Adult; D002352:Carrier Proteins / Q000378:metabolism; D016022:Case-Control Studies; D002677:Chile; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D006951:Hyperlipoproteinemias / Q000201:enzymology / Q000378:metabolism*; D007009:Hypolipoproteinemias / Q000201:enzymology / Q000378:metabolism*; D008049:Lipase / Q000097:blood*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D006023:Glycoproteins; C504173:LIPC protein, human; D008049:Lipase; D008071:Lipoprotein Lipase
Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos.