title: Synthesis of novel 26-substituted milbemycin A4 derivatives and their acaricidal activities.
abstract: A series of novel 26-substituted milbemycin A4 derivatives was synthesized from 5-O-t-butyldimethylsilyl-26-hydroxymilbemycin A4 prepared by selenium dioxide oxidation of 5-O-t-butyldimethylsilyl-milbemycin A4. Their acaricidal activities were assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
authors.affiliation: Agroscience Research Laboratories, Sankyo Co., Ltd. 894, Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. tukiya@Sankyo-agro.co.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsukiyama
authors.forename: Hisaki
authors.initials: H
authors.lastname: Kajino
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: Harumi
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yanai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sato
authors.forename: Shinji
authors.initials: S
authors.lastname: Yokoi
authors.forename: Reiji
authors.initials: R
authors.lastname: Ichinose
authors.forename: Keiji
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology; D008925:Mites / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D018942:Macrolides; C027837:moxidectin