Effects of dietary long chain PUFAs on hippocampal lipid peroxidation and NMDA receptor subunits A and B concentration in streptozotocin-diabetic rats.
This study examined the effects of streptozotocin (STZ)-diabetes and dietary long chain polyunsaturated fatty acids (LC-PUFAs) on hippocampal N-methyl-D-aspartate (NMDA) receptor subunit expression and lipid peroxidation. MDA level was significantly increased after 8 weeks of STZ-diabetes. LC-PUFAs administration significantly reduced MDA levels in diabetic rats. NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats. Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats. Consequently, dietary LC-PUFAs can partially restore hippocampal NMDA receptors and decrease lipid peroxidation in diabetes. LC-PUFAs are thus a possible prophylactic means for preventing the cognitive deficiencies of diabetes.
Delibas
Namik
N
Suleyman Demirel University, Faculty of Medicine, Department of Biochemistry and Physiology, Isparta, Turkey. delibas@med.sdu.edu.tr
Altuntas
Irfan
I
Sutcu
Recep
R
Yonden
Zafer
Z
Koylu
Halis
H
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D015153:Blotting, Western / Q000379:methods; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism*; D018709:Statistics, Nonparametric
D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate; D008315:Malondialdehyde