Difluorophenylsulfanylmethyl radical and difluoromethylene diradical synthons: gem-difluoromethylene building block.
Bromodifluorophenylsulfanylmethane has been demonstrated to be a highly versatile gem-difluoromethylene (CF2) building block via the reaction of difluorophenylsulfanylmethyl radical with olefins. gem-Difluoroalkenes and products containing a midchain CF2 group and with manipulatable functionality can be readily synthesized. The first example of a gem-difluoromethylene radical synthon is also reported.
Reutrakul
Vichai
V
Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. scvrt@mahidol.ac.th
Thongpaisanwong
Thanchanok
T
Tuchinda
Patoomratana
P
Kuhakarn
Chutima
C
Pohmakotr
Manat
M