title: Slime production by clinical isolates of Blastoschizomyces capitatus from patients with hematological malignancies and catheter-related fungemia.
abstract: In order to expand the present knowledge of the pathogenic potential of Blastoschizomyces capitatus in central venous catheter (CVC)-related bloodstream infections, six strains of the organism recovered from three leukemic patients with CVC-related fungemia in different years were investigated. Isolates and control strains were tested for their genetic relatedness and for their ability to produce slime in glucose-containing solutions. DNA restriction enzyme analysis revealed that all strains of B. capitatus were identical, whereas slime production assays and examination of ex vivo material showed that they were able to produce large amounts of slime. Slime production may therefore play a relevant pathogenic role in cases of CVC-related fungemia caused by B. capitatus.
authors.affiliation: Unità Operativa di Microbiologia e Virologia Clinica, Dipartimento di Ematologia ed Oncologia, Ospedale Spirito Santo, Via Fonte Romana 8, 65100 Pescara, Italy. domenicodantonio@virgilio.it
authors.forename: D
authors.initials: D
authors.lastname: D'Antonio
authors.forename: G
authors.initials: G
authors.lastname: Parruti
authors.forename: E
authors.initials: E
authors.lastname: Pontieri
authors.forename: G
authors.initials: G
authors.lastname: Di Bonaventura
authors.forename: L
authors.initials: L
authors.lastname: Manzoli
authors.forename: R
authors.initials: R
authors.lastname: Sferra
authors.forename: A
authors.initials: A
authors.lastname: Vetuschi
authors.forename: R
authors.initials: R
authors.lastname: Piccolomini
authors.forename: F
authors.initials: F
authors.lastname: Romano
authors.forename: T
authors.initials: T
authors.lastname: Staniscia
mesh_terms: D018441:Biofilms / Q000254:growth & development*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D016469:Fungemia / Q000209:etiology / Q000382:microbiology*; D005848:Geotrichum / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000150:complications; D003904:Mitosporic Fungi / Q000302:isolation & purification / Q000378:metabolism*; D014250:Trichosporon / Q000378:metabolism