title: Metal content of saliva of patients with and without metal restorations.
abstract: Many in vitro studies have confirmed the corrosion of dental alloys. However, in vivo corrosion studies, for example, recording of the release of metal ions into saliva, are scarce, and data on the repeatability of the metal content measurements of saliva are lacking. The present study examined the metal content of saliva of patients with and without metal restorations and assessed the repeatability of these data. The composition of each patient's oral cast alloys was analyzed using the energy-dispersive X-ray analysis of metal biopsy specimens and was compared to the metals found in saliva. Saliva analysis was performed using atomic absorption spectroscopy. Chemical analysis comprised the metals Ag, Au, Co, Cr, Cu, Fe, Ga, In, Ni, Pd, Pt, Sn, and Zn. The metals Ag, Cr, Cu, Fe, Ni, and Zn were found in saliva of patients without metal restorations, but these data showed statistically significant differences in the metal content between consecutively performed samples per patient. The metals Ag, Au, Cr, Cu, Fe, Ni, and Zn were identified in saliva of patients with metal restorations being higher in concentration than in control patients. In 77% of the cases at least one metal of the restoration was found in the patient's saliva. However, the metal content showed statistically significant differences between replicate samples of the same patient taken at different times. The metal content of saliva is affected among other things by intraoral metal restorations, but present data do not support the idea that it is a reliable indicator for the systemic exposure to metals released from dental alloys.
authors.affiliation: Department of Operative Dentistry and Periodontology, Regensburg University Hospital, 93042 Regensburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Garhammer
authors.forename: K-A
authors.initials: KA
authors.lastname: Hiller
authors.forename: T
authors.initials: T
authors.lastname: Reitinger
authors.forename: G
authors.initials: G
authors.lastname: Schmalz
mesh_terms: D002857:Chromium / Q000032:analysis; D003300:Copper / Q000032:analysis; D003722:Dental Alloys / Q000032:analysis*; D003793:Dental Restoration, Permanent; D004577:Electron Probe Microanalysis; D005708:Gallium / Q000032:analysis; D006046:Gold / Q000032:analysis; D006801:Humans; D007204:Indium / Q000032:analysis; D007501:Iron / Q000032:analysis; D008670:Metals / Q000032:analysis*; D009532:Nickel / Q000032:analysis; D010165:Palladium / Q000032:analysis; D010984:Platinum / Q000032:analysis; D015203:Reproducibility of Results; D012463:Saliva / Q000737:chemistry*; D012834:Silver / Q000032:analysis; D013054:Spectrophotometry, Atomic; D014001:Tin / Q000032:analysis; D015032:Zinc / Q000032:analysis
chemical_list: D003722:Dental Alloys; D008670:Metals; D007204:Indium; D002857:Chromium; D012834:Silver; D010984:Platinum; D010165:Palladium; D014001:Tin; D006046:Gold; D003300:Copper; D009532:Nickel; D005708:Gallium; D007501:Iron; D015032:Zinc