title: [Modern therapy of COPD].
abstract: Although the prevalence of chronic obstructive pulmonary disease (COPD) is gradually increasing in all industrialized countries, there have been relatively few treatment advances. Recently, a better understanding of the cellular and molecular mechanisms involved in the inflammatory and destructive processes underlying COPD has identified new therapeutic targets. Several classes of drug are now in preclinical and clinical development: phosphodiesterase-4 inhibitors, protease inhibitors and remodelling agents such as retinoic acid will be available in the near future.
authors.forename: René
authors.initials: R
authors.lastname: Pariente
authors.forename: Michel
authors.initials: M
authors.lastname: Aubier
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D004791:Enzyme Inhibitors; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4
vernacular_title: Avancées thérapeutiques dans les bronchopneumopathies chroniques obstructives.