title: Ganglioside complexes as new target antigens in Guillain-Barré syndrome.
abstract: Antibodies specific for a complex of gangliosides GD1a and GD1b (GD1a/GD1b) were found in sera from eight of 100 patients with Guillain-Barre syndrome (GBS) by the use of enzyme-linked immunosorbent assay and thin-layer chromatogram immunostaining. Those sera also had antibody activities to such ganglioside complexes as GD1a/GM1, GD1b/GT1b, and GM1/GT1b but had little or no reactivity to the each isolated antigen. Clustered epitopes of the ganglioside complex in the plasma membrane may be targeted by such an antibody, and interaction between the antibody and ganglioside complex may induce the neuropathy.
authors.affiliation: Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kaida
authors.forename: Daiji
authors.initials: D
authors.lastname: Morita
authors.forename: Mami
authors.initials: M
authors.lastname: Kanzaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Kamakura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Motoyoshi
authors.forename: Minako
authors.initials: M
authors.lastname: Hirakawa
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D002855:Chromatography, Thin Layer / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005732:Gangliosides / Q000097:blood / Q000276:immunology; D005733:Gangliosidoses / Q000097:blood / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood* / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D008297:Male; D008875:Middle Aged
chemical_list: D000906:Antibodies; D005732:Gangliosides; C021298:ganglioside, GD1a; C033851:ganglioside, GD1b