Characterisation of advanced glycation endproducts in saliva from patients with diabetes mellitus.
Patients with diabetes mellitus are prone to develop increased advanced glycation endproducts causing local complications and increased overall morbidity and mortality. Nuclear magnetic resonance spectra were determined in saliva of 52 consecutive patients with diabetes mellitus and 47 age-matched healthy control subjects. Resonance spectra showed specific peaks at 2.3, 7.3, and 8.4 ppm in saliva from patients with diabetes mellitus. These peaks could be generated by incubation of saliva from healthy control subjects with hypochloric acid in vitro, indicating the presence of advanced glycation endproducts. The presence of advanced glycation endproducts in patients with diabetes mellitus was associated with approximal plaque index, indicating increased periodontal damage. The study indicates that increased advanced glycation endproducts are involved in the pathogenesis of diabetic complications.
Yoon
Min-Sung
MS
Charité--Universitätsmedizin Berlin, Med. Klinik IV, CBF, Berlin, Germany.
Jankowski
Vera
V
Montag
Susanne
S
Zidek
Walter
W
Henning
Lars
L
Schlüter
Hartmut
H
Tepel
Martin
M
Jankowski
Joachim
J
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D017127:Glycation End Products, Advanced / Q000032:analysis* / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000175:diagnosis / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry*
D015415:Biomarkers; D017127:Glycation End Products, Advanced