Solid-phase synthesis of second-generation polyproline dendrimers.
Second-generation dendrimers have been prepared on solid phase by successive additions of branched polyproline building blocks starting from two different branching units anchored to the solid support. The preparation of Pro-rich building blocks was carried out by stepwise solid-phase synthesis and their iterative addition was performed by a convergent approach, also using solid-phase synthesis. cis-4-Amino-L-proline and imidazolidine-2-carboxylic acid were used as branching units due to their structural resemblance to proline. The optimized strategy allowed the target compounds to be obtained with high purities without the need for purification steps.
Sanclimens
Glòria
G
Barcelona Biomedical Research Institute, Barcelona Science Park, University of Barcelona, Josep Samitier 1, 08028 Barcelona, Spain.
Crespo
Laia
L
Giralt
Ernest
E
Royo
Miriam
M
Albericio
Fernando
F
D002851:Chromatography, High Pressure Liquid; D008722:Methods; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides; C011083:polyproline