title: Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor.
abstract: Pyrimidine methyl anilines as potent and selective mGlu2 potentiators are described. Findings from the structure-activity-relationship investigations are discussed.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, San Diego, CA 92121, USA. essa_hu@merck.com
authors.forename: Essa
authors.initials: E
authors.lastname: Hu
authors.forename: Peter C
authors.initials: PC
authors.lastname: Chua
authors.forename: Lida
authors.initials: L
authors.lastname: Tehrani
authors.forename: Johnny Y
authors.initials: JY
authors.lastname: Nagasawa
authors.forename: Anthony B
authors.initials: AB
authors.lastname: Pinkerton
authors.forename: Blake A
authors.initials: BA
authors.lastname: Rowe
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Vernier
authors.forename: John H
authors.initials: JH
authors.lastname: Hutchinson
authors.forename: Nicholas D P
authors.initials: ND
authors.lastname: Cosford
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000814:Aniline Compounds; D011743:Pyrimidines; D018094:Receptors, Metabotropic Glutamate; D013449:Sulfonamides; C108822:metabotropic glutamate receptor 2