Origin of stellate giant cells in oral fibrous lesions determined by immunohistochemical expression of vimentin, HHF-35, CD68 and factor XIIIa.
OBJECTIVE
To determine the origin of mono-, bi- and multinucleate stellate giant cells in giant cell fibroma, fibrous hyperplasia and fibroepithelial polyp of the oral mucosa.


METHODS
Ten cases of each lesion were studied immunohistochemically using anti-vimentin, -HHF-35, -CD68 and -factor XIIIa antibodies. Immunoreactivity of the cells was determined in the papillary and reticular lamina propria of these lesions.


RESULTS
Vimentin positivity in both the papillary and reticular lamina propria was observed for most samples, especially giant cell fibroma cases.


CONCLUSIONS
The immunohistochemical findings of the present study suggest that the mono-, bi- or multinucleate stellate giant cells observed in the lesions studied derived from the fibroblastic lineage.
Souza
Lélia B
LB
Laboratory of Oral Pathology, Dentistry School, Federal University of Rio Grande do Norte, 1787 CEP-59056-000 Natal, Brazil. leliasouza@dod.ufrn.br
Andrade
Emanuel S S
ES
Miguel
Márcia C C
MC
Freitas
Roseana A
RA
Pinto
Leão P
LP
D000199:Actins / Q000378:metabolism; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D019070:Cell Lineage; D026122:Factor XIIIa / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology; D005350:Fibroma / Q000378:metabolism* / Q000473:pathology; D015726:Giant Cells / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009059:Mouth Diseases / Q000378:metabolism* / Q000473:pathology; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology*; D011127:Polyps / Q000378:metabolism* / Q000473:pathology; D014746:Vimentin / Q000378:metabolism; D000097382:CD68 Molecule
D000199:Actins; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D026122:Factor XIIIa; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule