title: Signet ring cell adenocarcinoma of the urachus.
abstract: Signet ring cell adenocarcinoma of the urachus is an extremely rare variety of adenocarcinoma of the urachus; only 23 cases have been reported in the literature to date. In the present report we discuss two more cases of this type and review the literature. For our first case, a 17-year-old man was treated with partial cystectomy with en-bloc excision of the urachus and umbilicus. He received local radiotherapy because of positive surgical margins. Local recurrence occurred after 21 months of diagnosis and he was lost to follow up. For our second case, a 31-year-old man was found to have peritoneal carcinomatosis at the time of surgery and partial cystectomy was carried out as a palliative procedure for hematuria. He received six cycles of chemotherapy, a combination of methotrexate, vinblastine, adriamycin and cisplatinum. The patient's response to the chemotherapy lasted for 8 months, after which his disease progressed and he died 19 months after diagnosis.
authors.affiliation: Department of Surgery, Mohan Dai Oswal Cancer Treatment and Research Foundation, Ludhiana (Punjab), India.
authors.forename: Singh
authors.initials: S
authors.lastname: Daljeet
authors.forename: Singh
authors.initials: S
authors.lastname: Amreek
authors.forename: Jain
authors.initials: J
authors.lastname: Satish
authors.forename: Arora
authors.initials: A
authors.lastname: Raman
authors.forename: G S
authors.initials: GS
authors.lastname: Hara
authors.forename: Garg
authors.initials: G
authors.lastname: Lovneesh
authors.forename: B R
authors.initials: BR
authors.lastname: Prabhakar
authors.forename: Aggarwal
authors.initials: A
authors.lastname: Neeraj
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018279:Carcinoma, Signet Ring Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local; D009373:Neoplasms, Germ Cell and Embryonal / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D014497:Urachus; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D014747:Vinblastine; D004317:Doxorubicin; D002945:Cisplatin; D008727:Methotrexate