Intramolecular signaling in immunoglobulins -- new evidence emerging from the use of supramolecular protein ligands.
The postulated intramolecular signaling in immunoglobulins generated by antigen binding has been controversial for years. The high heterogeneity of immune complexes as signaling systems and the requirement of the immobilized antigen form for efficient triggering of effector activity is likely the reason for the lack of clarity. Here we present new evidence supporting the notion of intramolecular signaling, based on the use of supramolecular dyes that bind to signal-derived specific sites in immunoglobulins.
Piekarska
B
B
Institute of Medical Biochemistry, Jagiellonian University, Medical College, Kraków, Poland. mbpiekar@cyf-kr.edu.pl
Konieczny
L
L
Rybarska
J
J
Stopa
B
B
Spólnik
P
P
Roterman
I
I
Król
M
M
D000936:Antigen-Antibody Complex / Q000378:metabolism; D001665:Binding Sites; D004396:Coloring Agents; D003224:Congo Red; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D015398:Signal Transduction / Q000276:immunology*
D000936:Antigen-Antibody Complex; D004396:Coloring Agents; D007136:Immunoglobulins; D008024:Ligands; D003224:Congo Red