[Characteristics of a clinical course of immune cytopenias with a high titer of autoantibodies to the microsomal antigen of the thyroid gland].
OBJECTIVE
To ascertain the role of high antibodies (Ab) titers to microsomal antigen (MA) of the thyroid in clinical manifestations of cytopenic syndromes.


METHODS
Clinical data are presented on 144 patients with depressed hemopoiesis having different levels of thyroid Aab.


RESULTS
When the titer was significantly elevated (41% patients with immune cytopenias), hematological malignancies run with recurrences, remission is rare. Treatment of the thyroid pathology improves hematological indices in some cases though does not reduce titers of Ab thyroid MA.


CONCLUSIONS
Detection of autoimmune pathology of the thyroid is necessary not only for specification of the concurrent process diagnosis but also for initiation of adequate combined treatment.
Vinogradova
Iu E
IuE
Shinkarkina
A P
AP
Vinogradov
D L
DL
Poverennyĭ
A M
AM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology*; D003038:Cobamides / Q000172:deficiency; D005260:Female; D006402:Hematologic Diseases / Q000097:blood / Q000276:immunology*; D006410:Hematopoiesis; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D033862:Iron-Binding Proteins / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000276:immunology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D003038:Cobamides; D033862:Iron-Binding Proteins; C056658:TPO protein, human; D007453:Iodide Peroxidase
Osobennosti klinicheskogo techeniia immunnykh tsitopeniĭ, soprovozhdaiushchikhsia povyshennym titrom autoantitel k mikrosomal'nomu antigenu shchitovidnoĭ zhelezy.