[Clinical analysis of 61 patients with antiphospholipid syndrome].
OBJECTIVE
To investigate the clinical manifestations, diagnosis and treatment of anti-phospholipid syndrome (APS).


METHODS
61 patients with defined APS admitted from Jan 1986 to Dec 2002 were analyzed retrospectively.


RESULTS
10 patients with primary APS and 51 patients with secondary APS were analyzed. Women were affected 3.1 times as that of men. 48 of the 51 (94.1%) patients with secondary APS were complicated with other autoimmune diseases, including 33 cases (64.7%) of systemic lupus erythematosus. Vascular thrombosis was presented in around 80.3% of the patients in this study. Thrombosis frequently involved the gastrointestinal system (21 cases, 22.6%), pulmonary system (19 cases, 20.4%), the cerebral vascular system (17 cases, 18.3%), lower limb deep venous system (16 cases, 17.2%), and infrequently coronary arteries or adrenal glands. The abnormal pregnancy rate in the 37 married women was 45.9%. The prevalence of anticardiolipin antibody (ACL) and lupus anticoagulant (LA) was 77.0% and 62.3% respectively. LA was associated with ACL.


CONCLUSIONS
APS occurs most commonly among young women, is a disorder characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with positive ACL or LA. Thrombosis frequently occurs in gastrointestinal system, pulmonary system, cerebral vascular system and deep venous system. The association between clinical features of APS and antiphospholipid antibody is significant. LA is a stronger risk factor for thrombosis and abnormal pregnancy than ACL. Antiplatelet with low-dosage aspirin and long-term anticoagulation are main therapeutics.
Leng
Xiao-mei
XM
Department of Rheumatology & Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical Colleges, Beijing 100730, China.
Liu
Xiao-min
XM
Ai
Mai-xing
MX
Zeng
Xiao-feng
XF
Tang
Fu-lin
FL
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013927:Thrombosis / Q000150:complications / Q000276:immunology
D017153:Antibodies, Anticardiolipin; D001323:Autoantibodies