title: Diaryloxy methano phenanthrenes: a new class of antituberculosis agents.
abstract: A new series of diaryloxy methano phenanthrenes were prepared through tertiary-aminoalkylations of [(methoxy-phenyl)-phenanthren-9-yl-methyl]-phenols obtained from Friedel-Crafts alkylations on (methoxy-phenyl)-phenanthren-9-yl-methanols. These series of compounds were evaluated against Mycobacterium tuberculosis H37Rv and showed the desired activity in the range of 6.25 microg/mL in vitro. One of the compound 12j protects the mice from the challenge of M. tuberculosis in vivo, as 30% of the mice were survived at treatment of 50 mg/kg body weight.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India. gautam_panda@lycos.com
authors.forename: Gautam
authors.initials: G
authors.lastname: Panda
authors.lastname: Shagufta
authors.forename: Jitendra Kumar
authors.initials: JK
authors.lastname: Mishra
authors.forename: Vinita
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: Anil K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Ranjana
authors.initials: R
authors.lastname: Srivastava
authors.forename: Brahm S
authors.initials: BS
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D010616:Phenanthrenes