Effects of GM-CSF on the neural progenitor cells.
Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent hematopoietic cytokine, which stimulates stem cell proliferation in the bone marrow. We now report that GM-CSF receptors expressed on neural progenitor cells and can mediate a biological response in cells to treat with GM-CSF treated neural progenitor cells exhibited a proliferative response and a marked decrease in terminal differentiation to mature neuron or astrocytes. GM-CSF treatment also suppressed neural progenitor cell apoptosis. These findings suggest that GM-CSF can stimulate the proliferation and inhibit the apoptosis of neural progenitor cells to expand the progenitor population, and that GM-CSF has a potential role in neural development or repair.
Kim
Jin Kyun
JK
Department of Neurosurgery, Inha University College of Medicine, 7-206, shinheung-dong 3ga, Chung-gu, Inchon, Korea.
Choi
Byung Hyun
BH
Park
Hyung Chun
HC
Park
So Ra
SR
Kim
Young Soo
YS
Yoon
Seung Hwan
SH
Park
Hyun Seon
HS
Kim
Eun Young
EY
Ha
Yoon
Y
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000819:agonists / Q000096:biosynthesis; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor