Non-peptide antigens activating human Vgamma9/Vdelta2 T lymphocytes.
Various non-peptidic ligands which specifically activate most of circulating human Vgamma9/Vdelta2 T lymphocytes are now known. Most of these are so-called phosphoantigens and directly trigger the Vgamma9/Vdelta2 TCR expressing cells, without need for MHC-restricted presentation molecules. Although some potent phosphoantigens currently involved in clinical trials are chemically-synthesized molecules, most of the natural antigens were isolated from microbial cultures. The structures and biosynthesis of phosphoantigens are reviewed here and the possible physiological significance of their recognition by gammadelta T lymphocytes is discussed.
Poupot
Mary
M
département Oncogénèse and Signalisation dans les Cellules Hématopoiétiques, Unité 563 de l'Institut National de la Santé Et de la Recherche Médicale, Centre de Physiopathologie de Toulouse Purpan, BP3028, 31024 Toulouse, France.
Fournié
Jean-Jacques
JJ
D000818:Animals; D000941:Antigens / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013729:Terpenes / Q000378:metabolism
D000941:Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013729:Terpenes