title: [Synthesis and antioxiactivity of squamosamide cyclic analogs].
abstract: OBJECTIVE
  To design and synthesize a series of squamosamide cyclic analogues and to test their antioxidation activity.
  
  
  METHODS
  Eleven 3-substituted indole-2-one derivatives were designed and synthesized through 9 steps with p-hydroxyphenylacetic acid as the starting material and their structures were confirmed by nuclear magnetic resonance and mass spectrometry.
  
  
  RESULTS
  Eleven compounds showed antioxidation activity and the activities of compounds 9 and 13 matches the positive control FLZ-52.
  
  
  CONCLUSIONS
  Cyclic reconstruction with FLZ-52 as the lead compound have some antioxidation activity.
authors.affiliation: Department of Drug Synthesis, Institute of Materia Medica, CAMS and PUMC, Beijing 100050, China. pingxie123@vip.sohu.net
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Xiao-zhen
authors.initials: XZ
authors.lastname: Jiao
authors.forename: Xiao-tian
authors.initials: XT
authors.lastname: Liang
authors.forename: Wei-hong
authors.initials: WH
authors.lastname: Feng
authors.forename: Huai-ling
authors.initials: HL
authors.lastname: Wei
authors.forename: Geng-tao
authors.initials: GT
authors.lastname: Liu
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D044482:Benzeneacetamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D044482:Benzeneacetamides; D010636:Phenols; C084439:squamosamide