Antigenicity and immunogenicity of collagen.
Pertinent issues of collagen antigenicity and immunogenicity are concisely reviewed as they relate to the design and application of biomedical devices. A brief discussion of the fundamental concepts of collagen immunochemistry is presented, with a subsequent review of documented clinical responses to devices containing reconstituted soluble or solubilized collagen. The significance of atelocollagen, concerns regarding collagen-induced autoimmunity, and other relevant topics are also addressed in the context of current understanding of the human immune response to collagen.
Lynn
A K
AK
Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Pembroke Street, CB2 3QZ UK. akl28@cam.ac.uk
Yannas
I V
IV
Bonfield
W
W
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001672:Biocompatible Materials / Q000009:adverse effects; D003094:Collagen / Q000276:immunology*; D003432:Cross-Linking Reagents; D004864:Equipment and Supplies / Q000009:adverse effects; D006801:Humans
D000941:Antigens; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003094:Collagen