Modulation of synaptic strength: subunit expression controls the critical period. Focus on "viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptors and restores NT-3-Induced potentiation of AMPA-kainate responses in maturing rat motoneurons".
Frank
Eric
E
D000818:Animals; D003423:Critical Period, Psychological; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005822:Genetic Vectors; D007608:Kainic Acid / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology*; D009046:Motor Neurons / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000502:physiology; D020933:Neurotrophin 3 / Q000494:pharmacology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000235:genetics* / Q000378:metabolism*; D017661:Receptors, Presynaptic / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology*
D018690:Excitatory Amino Acid Agonists; C464436:NR2D NMDA receptor; D020933:Neurotrophin 3; D016194:Receptors, N-Methyl-D-Aspartate; D017661:Receptors, Presynaptic; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D008274:Magnesium; D007608:Kainic Acid