Dietary isoflavones suppress endotoxin-induced inflammatory reaction in liver and intestine.
Dietary isoflavone intake has been linked to cancer prevention and their anti-inflammation activity was examined. Intraperitoneal lipopolysaccharide (LPS) injection in mice led to a decrease in the liver antioxidant glutathione level but this decrease was prevented in mice fed with an isoflavone-containing diet. Similarly, isoflavone diet prevented the inflammation-associated induction of metallothionein (MT) in the intestine; and the induction of manganese superoxide dismutase (Mn-SOD) in the liver. Results from the intestinal cell studies suggest that isoflavones suppress the intestinal response to inflammation by modulating the action of pro-inflammatory cytokine, IL-6. IL-6 secretion and the STAT3 (signal transducer and activator of transcription protein 3) nuclear translocation in response to IL-6 were both decreased by genistein.
Paradkar
Prasad N
PN
Department of Exercise and Nutrition Sciences, University at Buffalo, 15 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA.
Blum
Penny S
PS
Berhow
Mark A
MA
Baumann
Heinz
H
Kuo
Shiu-Ming
SM
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000378:metabolism; D004032:Diet; D019833:Genistein / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D007529:Isoflavones / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D021381:Protein Transport / Q000187:drug effects; D050796:STAT3 Transcription Factor; D013482:Superoxide Dismutase / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism
D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D015850:Interleukin-6; D007529:Isoflavones; D008070:Lipopolysaccharides; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C494087:Stat3 protein, mouse; D015534:Trans-Activators; D008668:Metallothionein; D019833:Genistein; D013482:Superoxide Dismutase; D005978:Glutathione