title: [Aerosolized iloprost combined with a phosphodiesterase inhibitor in the treatment of primary pulmonary hypertension].
abstract: Iloprost, a prostacyclin analogue administered by inhalation, improves hemodynamic and functional class variables in patients with primary pulmonary hypertension. However, repetitive inhalations are required due to its short term effects. One potential approach to prolong and increase the effects of aerosolized iloprost might be to combine its use with phosphodiesterase inhibitors. We report a 36 year old female patient with primary pulmonary hypertension treated with this combination. After 18 months of therapy the patient had an improvement in functional class and in the 6 min walk distance despite persistence of high pulmonary pressures. Our case is in agreement with the reported beneficial effect of the association of sildenafil and iloprost. We postulate that functional improvement in primary pulmonary hypertension is not always related to a decrease in pulmonary artery pressure.
authors.affiliation: Departamento de Enfermedades Cardiovasculares, Hospital Clínico y Facultad de Medicina, Pontificia Universidad Católica de Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Isa
authors.forename: Pablo
authors.initials: P
authors.lastname: Castro
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martínez
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D016285:Iloprost / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D016285:Iloprost
vernacular_title: Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria.