Bcl-2 and immunoglobulin gene rearrangements in patients with malaria related chronic splenomegaly.
Two cases of malaria related chronic splenomegaly, one with tropical splenic lymphoma with villous lymphocytes (TSLVL) and the other with hyperreactive malarial splenomegaly (HMS) were analyzed by cytology, histology, karyotyping, immunophenotyping, and polymerase chain reaction (PCR) for detection of bcl-2/JH and FR3/JH rearrangements on blood and bone marrow samples, at diagnosis and 12 months after malarial prophylaxis. The reported data suggest that the detection of FR3/JH rearrangement might contribute to the diagnosis of TSLVL in patients with malaria related chronic splenomegaly, for whom bcl-2/JH rearrangement may be a common molecular event.
Dascalescu
Cristina Mihaela
CM
Centre Hospitalier Universitaire Saint-Antoine, 184 rue du Faubourg St. Antoine, 75571 Paris cedex 12, France.
Rosenzwajg
Michelle
M
Bonte
Hélène
H
Mir
Ilhem Agha
IA
Aoudjhane
Malek
M
Smadja
Nicole Véronique
NV
Lemoine
François M
FM
Najman
Albert
A
D000368:Aged; D001402:B-Lymphocytes; D002908:Chronic Disease; D005260:Female; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D008223:Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000469:parasitology; D008288:Malaria / Q000150:complications*; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000469:parasitology; D013163:Splenomegaly / Q000235:genetics* / Q000469:parasitology*
D007143:Immunoglobulin Heavy Chains; D019253:Proto-Oncogene Proteins c-bcl-2