The antiparasitic compound licochalcone a is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed.
The well-known antiparasitic compound licochalcone A is a potent membrane-active agent that transforms normal erythrocytes into echinocytes in parallel with the inhibition of growth of Plasmodium falciparum cultures, the in vitro antiplasmodial effect apparently being an indirect effect on the host cell. In vitro experiments with synchronous cultures demonstrate that inhibition of invasion is the principal mechanism of growth inhibition. The erythrocyte membrane-modifying effect was also transiently observed in vivo in mice after intravenous administration.
Ziegler
Hanne L
HL
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Hansen
Harald S
HS
Staerk
Dan
D
Christensen
Søren Brøgger
SB
Hägerstrand
Henry
H
Jaroszewski
Jerzy W
JW
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology*; D002599:Chalcone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D047188:Chalcones; D002851:Chromatography, High Pressure Liquid; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006801:Humans; D007275:Injections, Intravenous; D051379:Mice; D046529:Microscopy, Electron, Transmission; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D047188:Chalcones; D002599:Chalcone; C070840:licochalcone A