Expression of Alzheimer's amyloid precursor protein in human lymphocyte.
Beta-amyloid precursor protein (betaAPP) has been shown to be involved in cell growth regulation. In spleen, the majority of cells showing betaAPP like immunoreactivity was found in the T cell-dependent zone. In Northern blot, the expression of betaAPP was increased to reach the peak at 72 h after the treatment of phytohemagglutinin (PHA). But, in cytofluorometry, almost all CD4(+) T helper/inducer cells and the majority of CD(8+) T suppressor/cytotoxic cells show betaAPP immunoreactivity which remained constant during the stimulation with PHA. These results suggest that betaAPP is a surface molecule of T lymphocyte and the turnover or release of APP might be increased with the treatment of T cell mitogen.
Suh
Y H
YH
Department of Pharmacology, College of Medicine, Neuroscience Research Institute, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-799, South Korea.
Choi
W
W
Kim
S H
SH
Kim
J S
JS
Rhi
B Y
BY
Chong
Y H
YH
Woo
J I
JI
Lee
K W
KW