title: [Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphosarcoma].
abstract: OBJECTIVE
  Efficacy of the treatment of primary mediastinal B-cell lymphosarcoma depends to a great extent on early diagnosis and treatment policy. In this study we evaluated possibilities of diagnosis and treatment of thrombotic complications of primary mediastinal B-cell lymphosarcoma (PMBL).
  
  
  METHODS
  61 patients were examined using roentgenography, computed tomography, chest ultrasound investigation,coagulogram, allelle specific polymerase chain reaction, ultrasound investigation of the jugular, subclavian, brachial veins, vena cava superior to detect mutation of genes II, V factors and methylentetrahydrofolatereductase.
  
  
  RESULTS
  In 7 cases prechemotherapy examination detected thrombosis of the internal jugular and subclavian veins. In 4 of 7 cases there was a combined thrombosis of the left internal jugular and subclavian veins, in 3 cases one the vessels was affected with thrombosis. In 2 cases, in the course of polychemotherapy, there was recurrent thrombosis and development of pulmonary artery thromboembolism (PATE). In progression of the disease there was thrombosis of the left subclavian vein (1 case) and PATE (a case). Coagulologically, hypercoagulation syndrome signs were registered. 5 patients with PMBL complicated by thromboses showed gene mutations.
  
  
  CONCLUSIONS
  In PMBL there is a tendency to formation of venous thrombosis and development of PATE. This is explained by tumor process and hereditary factors of thrombogenicity. Therefore, specific antitumor treatment should include anticoagulation therapy.
authors.forename: B T
authors.initials: BT
authors.lastname: Dzhumabaeva
authors.forename: A M
authors.initials: AM
authors.lastname: Kremenetskaia
authors.forename: S A
authors.initials: SA
authors.lastname: Vasil'ev
authors.forename: E M
authors.initials: EM
authors.lastname: Shulutko
authors.forename: S K
authors.initials: SK
authors.lastname: Kravchenko
authors.forename: A A
authors.initials: AA
authors.lastname: Shevelev
authors.forename: E V
authors.initials: EV
authors.lastname: Sergeeva
authors.forename: Ia D
authors.initials: IaD
authors.lastname: Sakhibov
authors.forename: E B
authors.initials: EB
authors.lastname: Orel
authors.forename: E A
authors.initials: EA
authors.lastname: Romanova
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000097:blood / Q000150:complications* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D008479:Mediastinal Neoplasms / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants
vernacular_title: Vozmozhnosti diagnostiki i lecheniia tromboticheskikh oslozhneniĭ pri pervichnoĭ mediastenal'noĭ B-kletochnoĭ limfosarkome.