Modafinil in endozepine stupor. A case report.
BACKGROUND
Endozepine-4 stupor is a rare disorder. It presents with recurrent episodes of stupor and coma. Endozepine-4 levels are elevated during an attack with electroencephalogram showing fast activity during the ictal phase. There is no specific treatment and various drugs have been tried without long-term benefit.


METHODS
We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor.


RESULTS
The vigilance promoting drug modafinil prevented recurrent episodes of stupor and coma in this patient at a dose of 200 mg/day for a period of six months. Upon withdrawal of the drug, the patient experienced recurrent episodes and on reinstitution of modafinil she has remained asymptomatic in the following one year.
Scott
Sharon
S
Department of Family Practice, Trinity Lutheran Hospital, Kansas City, Missouri, USA.
Ahmed
Iftekhar
I
D000284:Administration, Oral; D000368:Aged; D001559:Benzhydryl Compounds / Q000008:administration & dosage*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D003128:Coma / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D026261:Diazepam Binding Inhibitor / Q000378:metabolism*; D005260:Female; D006801:Humans; D000077408:Modafinil
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D026261:Diazepam Binding Inhibitor; D000077408:Modafinil