Cord blood myeloperoxidase in preterm infants with periventricular hyperechogenicity.
BACKGROUND
Cytokines, adhesion molecules, and inflammatory mediators are believed to play central roles in the pathophysiologic mechanisms of brain white matter lesions. To examine the relationships of cytokines, adhesion molecules, and inflammatory mediators in the cord blood of preterm infants and neonatal cerebral ultrasound periventricular hyperechogenicity (PVH), cord blood cytokines, adhesion molecules, and inflammatory mediators were analyzed, and routine cerebral ultrasound scans were performed in all 96 premature infants.


METHODS
The non-PVH group consisted of 20 infants with normal cerebral ultrasound findings during the first week of life. The PVH group consisted of 20 infants with PVH during the first week of life. Cytokines, adhesion molecules, and inflammatory mediators in cord blood including interleukin-8 (IL-8), prostaglandin E2 (PGE2), P-selectin, soluble vascular cell adhesion molecules (sVCAMs), and myeloperoxidase (MPO) were examined by enzyme-linked immunosorbent assay.


RESULTS
There were no significant differences in IL-8, PGE2, P-selectin, and sVCAM levels between patients with and without PVH. Interestingly, MPO levels were marginally significantly higher in patients with PVH than those without PVH (7.46 +/- 3.6 vs. 4.81 +/- 3.5; p = 0.024).


CONCLUSIONS
It is concluded that MPO from leukocytes may contribute to the occurrence of PVH in premature infants.
Wang
Chien-An
CA
Department of Pediatrics, Chang Gung Children's Hospital, Kaoshiung, Taiwan.
Yang
Kuender D
KD
Huang
Chung-Bin
CB
Huang
Hsin-Chun
HC
Huang
Li-Tung
LT
D001921:Brain / Q000473:pathology* / Q000648:ultrastructure; D015232:Dinoprostone / Q000097:blood; D004453:Echoencephalography; D004797:Enzyme-Linked Immunosorbent Assay; D005312:Fetal Blood / Q000201:enzymology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D016209:Interleukin-8 / Q000097:blood; D019007:P-Selectin / Q000097:blood; D009195:Peroxidase / Q000097:blood*; D012995:Solubility; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D016209:Interleukin-8; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D009195:Peroxidase; D015232:Dinoprostone