title: Three cases of ischemic ulcer due to arteriosclerosis obliterans responding to basic fibroblast growth factor spray.
abstract: The management of the chronically ischemic leg with ulcer formation that is not suitable for either surgical or interventional treatment is still a matter of controversy. We describe three cases of ischemic ulcer treated with basic fibroblast growth factor spray. Ulcer healing was accelerated and complete epithelialization was achieved in all cases. Basic fibroblast growth factor spray is useful in the treatment of the ischemic ulcer in patients with arteriosclerosis obliterans, especially in high-risk surgical patients.
authors.affiliation: Department of Cardiovascular Surgery, Nagasaki Municipal Medical Center, 20-5 Fuchi-machi, 852-8012, Nagasaki, Japan, m-nogu@ngs2.cncm.ne.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Noguchi
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Eishi
authors.forename: Shiro
authors.initials: S
authors.lastname: Yamachika
authors.forename: Shiro
authors.initials: S
authors.lastname: Hazama
mesh_terms: D000287:Administration, Topical; D000336:Aerosols; D000368:Aged; D000369:Aged, 80 and over; D001162:Arteriosclerosis Obliterans / Q000150:complications*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D005528:Foot / Q000098:blood supply*; D016523:Foot Ulcer / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007511:Ischemia / Q000150:complications* / Q000209:etiology; D008297:Male; D017468:Receptors, Fibroblast Growth Factor; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000336:Aerosols; D017468:Receptors, Fibroblast Growth Factor; D016222:Fibroblast Growth Factor 2