Bone morphogenetic proteins in vertebrate hematopoietic development.
During embryonic development, the hematopoietic system is the first to generate terminally differentiated, functional cell types. The urgent necessity for the early formation of blood and blood vessels during embryogenesis means that the induction, expansion, and maturation of these systems must be rapidly and precisely controlled. Bone morphogenic proteins (BMPs) have been implicated in hematopoietic development in the vertebrate embryo and stimulate the proliferation and/or differentiation of human cord blood hematopoietic stem cells (HSC) and embryonic stem cells in vitro. Here we review the mechanisms of action and potential roles of these soluble signaling molecules in vertebrate hematopoiesis.
Snyder
Alexandra
A
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
Fraser
Stuart T
ST
Baron
Margaret H
MH
D000818:Animals; D052004:Bone Morphogenetic Protein Receptors; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D006410:Hematopoiesis; D006801:Humans; D017978:Receptors, Growth Factor / Q000378:metabolism; D015398:Signal Transduction; D014714:Vertebrates
D019485:Bone Morphogenetic Proteins; D017978:Receptors, Growth Factor; D052004:Bone Morphogenetic Protein Receptors