title: A practical method for oxazole synthesis by cycloisomerization of propargyl amides.
abstract: [reaction: see text] 2,5-disubstituted and 2,4,5-trisubstituted oxazol-5-yl carbonyl compounds were prepared in good yields by a mild SiO2-mediated cycloisomerization of propargyl amides.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Tyler E
authors.initials: TE
authors.lastname: Benedum
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D010080:Oxazoles / Q000138:chemical synthesis*; D012822:Silicon Dioxide / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D010080:Oxazoles; D012822:Silicon Dioxide