New ion exchange materials for use in a 82Sr/82Rb generator.
82Rb is a short-lived positron-emitting isotope (T1/2 = 75 s) that is increasingly being used in positron emission tomography for the evaluation of myocardial perfusion. The short half-life of 82Rb results in rapid decay of the administered radioactivity allowing repeat scans to be performed after a relatively short time interval. The 82Rb is available from a 82Sr/82Rb generator in which the 82Sr parent is immobilized on an ion exchange column and 82Rb eluted when required. Consequently, suitable ion exchangers for use in a generator must have a very high affinity for strontium and a negligible affinity for rubidium, allowing the pure 82Rb to be safely and efficiently eluted in high yields. This study evaluated a number of strontium-selective ion exchange materials using batch experiments and identified sodium nonatitanate as the best material for use in a 82Sr/82Rb generator.
Sylvester
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P
Lynntech Inc., 7607 Eastmark Drive, College Station, TX 77840, USA. psylvester@solmetex.com
Möller
T
T
Adams
T W
TW
Cisar
A
A
D002852:Chromatography, Ion Exchange / Q000379:methods*; D007475:Ion Exchange Resins / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000302:isolation & purification; D012414:Rubidium Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification*; D013326:Strontium Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification*; D014025:Titanium / Q000737:chemistry*
D007475:Ion Exchange Resins; D019275:Radiopharmaceuticals; D012414:Rubidium Radioisotopes; D013326:Strontium Radioisotopes; D014025:Titanium