title: [Glucagonoma: a recent series of 7 cases].
abstract: We report a series of 7 glucagonoma patients seen between 1994 and 2001, 5 males and 2 females, aged 32-69 years, with: necrolytic migratory erythema (NME) (n = 2), liver metastases (n = 3), jaundice (n = 1) and 1 case of familial history of multiple endocrine neoplasia. The diagnosis combined histology and hyperglucagonemia; 6 patients developed metastasis (5 initially); during the follow-up 3 developed a necrolytic erythema migraticum (NEM) worsening the general status. Somatostatin receptor scanning was highly positive in all. Four patients were operated, 5 received chemotherapy (2 OR and 2 SD), 3 had chemoembolization (1 transient improvement). Somatostatin was efficient on general status or skin lesions in all patients. Two died and 5 are alive with a follow up ranging from 12 to 60 months. We want to emphasize on the higher frequency than expected of this disease, the frequency of NEM, the efficacy of SMS on NEM and general status and on the fairly good prognosis. The high uptake of SMS by tumors on scanning could rise hopes about radioconjugate therapy.
authors.affiliation: Département d'oncologie médicale, Centre Eugène Marquis, 35042 Rennes, FRANCE.
authors.forename: Elodie
authors.initials: E
authors.lastname: Vauleon
authors.forename: Joëlle
authors.initials: J
authors.lastname: Egreteau
authors.forename: Eveline
authors.initials: E
authors.lastname: Boucher
authors.forename: Véronique
authors.initials: V
authors.lastname: Desfourneaux
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bretagne
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Raoul
mesh_terms: D000328:Adult; D000368:Aged; D004890:Erythema / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005935:Glucagonoma / Q000150:complications* / Q000175:diagnosis / Q000556:secondary; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000175:diagnosis; D013004:Somatostatin / Q000627:therapeutic use
chemical_list: D006728:Hormones; D013004:Somatostatin
vernacular_title: Le glucagonome: à propos d'une série récente de 7 cas.