Ca2+ regulation and gene expression in normal brain aging.
Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca(2+) regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.
Toescu
Emil C
EC
Department of Physiology, Division of Medical Sciences, The University of Birmingham, Edgbaston B15 2TT, UK. e.c.toescu@bham.ac.uk <e.c.toescu@bham.ac.uk>
Verkhratsky
Alexei
A
Landfield
Philip W
PW
D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D009474:Neurons / Q000502:physiology*
D002118:Calcium