Bilineage acute leukemia of T-lymphoid and myeloid lineages.
We report the case of a child with Philadelphia chromosome-negative bilineage leukemia characterized by the coexistence of T-cell leukemia and myelomonocytic leukemia. Comparative analyses of genetic markers and proliferative/differentiative potential show the possibility of malignant transformation of a T-lineage stem cell with the potential to differentiate into the myeloid lineage.
Kobayashi
Norimoto
N
Matsuda
Kazuyuki
K
Sakashita
Kazuo
K
Matsuzaki
Satoshi
S
Iwasaki
Ryu
R
Koike
Kenichi
K
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D001483:Base Sequence; D002454:Cell Differentiation; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D018899:CpG Islands; D017809:Fatal Outcome; D006412:Hematopoietic Stem Cells / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology*; D008297:Male; D008954:Models, Biological; D008969:Molecular Sequence Data; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000473:pathology*; D013997:Time Factors
D015703:Antigens, CD