A hypothesis about the role of adult neurogenesis in hippocampal function.
The functional relevance of adult hippocampal neurogenesis has long been a matter of intense experimentation and debate, but the precise role of new neurons has not been sufficiently elaborated. Here we propose a hypothesis in which specific features of newly generated neurons contribute to hippocampal plasticity and function and discuss the most recent and relevant findings in the context of the proposed hypothesis.
Schinder
Alejandro F
AF
Laboratory of Neuronal Plasticity, Leloir Institute Foundation, 1405 Buenos Aires, Argentina. aschinder@leloir.org.ar
Gage
Fred H
FH
D000328:Adult; D000818:Animals; D002455:Cell Division / Q000502:physiology; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000166:cytology*