A two-holed story: structural secrets about ClC proteins become unraveled?
ClC Cl(-) channels are found in almost all organisms, ranging from bacteria to mammals, in which nine Cl(-) channels belonging to the ClC family have been identified. The biophysical properties and physiological functions of ClC Cl(-) channels have been extensively reviewed. In this short review, we will focus on recent results obtained on the X-ray structure and functional properties of the prokaryotic ClC-ec1 protein and some results obtained on the role of the cytoplasmic COOH terminus of mammalian ClCs.
Babini
Elena
E
Istituto di Biofisica, Consiglio Nazionale delle Ricerche, I-16149 Genova, Italy.
Pusch
Michael
M
D000818:Animals; D018118:Chloride Channels / Q000737:chemistry* / Q000502:physiology*; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
C086321:CLC-1 channel; D018118:Chloride Channels