title: Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors.
abstract: Long-term results are reported in 23 patients and short-term results in 30 patients presenting with bone tumors treated by curettage or resection followed by implantation of hydroxyapatite (HA) or highly purified beta-tricalcium phosphate (beta-TCP), respectively. Mean follow-up was 97 and 26 months in cases involving HA implantation and beta-TCP implantation, respectively. Radiographs revealed HA incorporation into host bone in all but two cases; moreover, no obvious evidence of HA biodegradation was observed. A single patient exhibited late deformity following implantation of HA. All grafted beta-TCP was, at least partially, absorbed and replaced by newly formed bone. The mean period required for the disappearance of radiolucent zones between the ceramics and host bone was 17 weeks in HA and 9.7 weeks in beta-TCP. Highly purified beta-TCP appears to be advantageous relative to HA for surgical intervention in bone tumors consequent to the nature of remodeling and superior osteoconductivity.
authors.affiliation: Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. aogose@med.niigata-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Ogose
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hotta
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawashima
authors.forename: Naoki
authors.initials: N
authors.lastname: Kondo
authors.forename: Wenguang
authors.initials: W
authors.lastname: Gu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamura
authors.forename: Naoto
authors.initials: N
authors.lastname: Endo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D018786:Bone Substitutes / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000378:metabolism / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006882:Hydroxyapatites / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C018392:tricalcium phosphate