title: Efficacy and tolerability of olanzapine in the treatment of schizotypal personality disorder.
abstract: BACKGROUND
  Few treatment studies of schizotypal personality disorder (SPD) have investigated the new, atypical antipsychotic drugs. This study examined the efficacy and tolerability of olanzapine, an atypical antipsychotic drug, in a series of patients with DSM-IV diagnosed schizotypal personality disorder.
  
  
  METHODS
  This was a 26-week, open-label study with flexible dose design in 11 subjects with a diagnosis of schizotypal personality disorder based on Structured Clinical Interview for DSM-IV (SCID) and Personality Disorder Examination (PDE Journal of Psychiatric Disorders 1 (1987) 1). Subjects were treated with a low dose (average 9.32 mg/day) of olanzapine. Psychopathology was assessed at baseline and at the end of the study and analyzed with last observation carried forward analysis.
  
  
  RESULTS
  Patients showed significant improvements in psychosis and depression ratings, as well as in overall functioning. Olanzapine was well tolerated, though significant weight gain was observed.
  
  
  CONCLUSIONS
  This study provides preliminary data regarding olanzapine efficacy and tolerability in schizotypal personality disorder subjects. These data need to be confirmed in larger controlled clinical trials.
authors.affiliation: University of Pittsburgh Medical Center, Health System-Western Psychiatric Institute and Clinic, Room 984, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. keshavanms@msx.upmc.edu
authors.forename: Matcheri
authors.initials: M
authors.lastname: Keshavan
authors.forename: Mujeeb
authors.initials: M
authors.lastname: Shad
authors.forename: Paul
authors.initials: P
authors.lastname: Soloff
authors.forename: Nina
authors.initials: N
authors.lastname: Schooler
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D010054:Brief Psychiatric Rating Scale; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D004562:Electrocardiography; D005500:Follow-Up Studies; D017048:Health Care Costs; D006801:Humans; D000077152:Olanzapine; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000188:drug therapy*; D012720:Severity of Illness Index
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine