title: Antigenicity and immunogenicity of collagen.
abstract: Pertinent issues of collagen antigenicity and immunogenicity are concisely reviewed as they relate to the design and application of biomedical devices. A brief discussion of the fundamental concepts of collagen immunochemistry is presented, with a subsequent review of documented clinical responses to devices containing reconstituted soluble or solubilized collagen. The significance of atelocollagen, concerns regarding collagen-induced autoimmunity, and other relevant topics are also addressed in the context of current understanding of the human immune response to collagen.
authors.affiliation: Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Pembroke Street, CB2 3QZ UK. akl28@cam.ac.uk
authors.forename: A K
authors.initials: AK
authors.lastname: Lynn
authors.forename: I V
authors.initials: IV
authors.lastname: Yannas
authors.forename: W
authors.initials: W
authors.lastname: Bonfield
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D001672:Biocompatible Materials / Q000009:adverse effects; D003094:Collagen / Q000276:immunology*; D003432:Cross-Linking Reagents; D004864:Equipment and Supplies / Q000009:adverse effects; D006801:Humans
chemical_list: D000941:Antigens; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003094:Collagen