Comparison of electrical thresholds for evoking movements from sensori-motor areas of the cat cerebral cortex and its relation to motor training.
Motor maps and electrical thresholds for evoking movements from motor areas of the cerebral cortex were evaluated in normal cats by using intracortical microstimulation techniques. Stainless steel chambers were implanted over craniotomies in adult cats trained to perform reaching and retrieval movements with their forelimbs. Prehensile motor training was continued and movement performance monitored for about 6-10 weeks during which the cortex was progressively explored with sharp tungsten electrodes inserted into cortical gyri (anterior and posterior sigmoid, and coronal) and the banks of sulci (cruciate, presylvian and coronal). Twice weekly, under light general anaesthesia, 3-4 tracks were made in either hemisphere till about 50 tracks were made in each hemisphere. Mean thresholds for evoking forelimb movements from different cytoarchitectonic areas (4gamma, 4delta, 6agamma and 3a) were compared and no consistent or significant differences were observed between the different areas. In the animals (4/6) which used either forelimb to perform the tasks, there were no consistent differences in the mean thresholds for evoking forelimb movements from the two hemispheres. However, in 2 animals, which used their right forelimbs predominantly or exclusively to perform all the tasks, mean thresholds for evoking forelimb movements was significantly higher in areas 4gamma and 6agamma of the left hemisphere (compared to the right); no consistent differences in the mean thresholds for evoking hindlimb or facial movements were observed between the two hemispheres. These findings suggest that ICMS thresholds for evoking forelimb movements may be similar in different sensorimotor areas of the cat cerebral cortex, and these thresholds could be influenced by motor training.
Ghosh
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Centre for Neuromuscular & Neurological Disorders, University of Western Australia, Perth, WA 6009, Australia. sghosh@cyllene.uwa.edu.au
Koh
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AH
Ring
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D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology*; D003399:Craniotomy; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004594:Electrophysiology; D005152:Facial Muscles / Q000294:innervation / Q000502:physiology; D005260:Female; D005552:Forelimb / Q000294:innervation / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology*; D009068:Movement / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*