Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis.
Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found significant elevation of tTG concentration in the cerebrospinal fluid (CSF) of 54 patients with Parkinson's disease (PD) compared with that measured in 34 control subjects, thus showing increased neural cell apoptosis in patients with PD.
Vermes
Istvan
I
Department of Clinical Chemistry, Medisch Spectrum Twente Hospital Group, Enschede, The Netherlands. i.vermes@ziekenhuis-mst.nl
Steur
Ernst N H Jansen
EN
Jirikowski
Gustav F
GF
Haanen
Clemens
C
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications; D017209:Apoptosis / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000150:complications / Q000503:physiopathology*; D011503:Transglutaminases / Q000134:cerebrospinal fluid*
D011503:Transglutaminases