title: Seropositivity for Helicobacter pylori antibodies is associated with lower occurrence of venous bypass graft occlusion.
abstract: Common chronic infections including those caused by cytomegalovirus (CMV), herpes simplex viruses (HSV), Helicobacter pylori and Chlamydia pneumoniae have previously been related to increased risk of coronary heart disease (CHD). We investigated the association between serology of these chronic infections and coronary bypass graft occlusions in 61 patients. As a result, IgG seropositivity rate against H. pylori was higher among patients without occlusion (82%) than in those with occlusion (45%) or apparently healthy controls (57%) (p = 0.004 and p = 0.008, respectively). In conclusion, H. pylori infection, as judged by IgG seropositivity, is associated with lower occurrence of venous bypass graft occlusion in patients with CHD and may thus be connected with better outcome and prognosis of CHD patients after bypass graft surgery.
authors.affiliation: Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
authors.forename: Vilho
authors.initials: V
authors.lastname: Limnell
authors.forename: Rafael
authors.initials: R
authors.lastname: Pasternack
authors.forename: Jussi
authors.initials: J
authors.lastname: Karjalainen
authors.forename: Vesa
authors.initials: V
authors.lastname: Virtanen
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Janne
authors.initials: J
authors.lastname: Aittoniemi
mesh_terms: D000328:Adult; D017677:Age Distribution; D000907:Antibodies, Bacterial / Q000032:analysis*; D000914:Antibodies, Viral / Q000032:analysis; D015331:Cohort Studies; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods; D003327:Coronary Disease / Q000175:diagnosis / Q000601:surgery; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D018139:Simplexvirus / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral