Comparison of endothelial function in young men and women with a family history of premature coronary artery disease.
Endothelial function was evaluated in 34 young men and women with a family history of premature coronary artery disease (CAD) and 28 control subjects. Men with a family history of CAD had significantly impaired flow-mediated, endothelium-dependent vasodilation of the brachial artery compared with controls; however, in women, there was no difference in flow-mediated vasodilation between subjects with a family history and controls.
Hamburg
Naomi M
NM
Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, 75 Francis Street, Boston, MA 02115, USA.
Charbonneau
François
F
Gerhard-Herman
Marie
M
Ganz
Peter
P
Creager
Mark A
MA
D000328:Adult; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D012737:Sex Factors; D014463:Ultrasonography; D014664:Vasodilation