Complex variant Philadelphia translocation involving the short arm of chromosome 9 in a case of chronic myeloid leukemia.
Here we describe how we detected the BCR/ABL fusion gene on the short arm of der(9) combining classical GTG banding and Fluorescence In Situ Hybridization (FISH) in a case of chronic myeloid leukemia (CML). To our knowledge, variant translocations involving the short arm of chromosome 9, in literature, are almost rare in chronic myeloid leukemia. It is not clear if this complex genetic translocation represents clonal evolution or a unique, initial presentation variant of the Philadelphia chromosome (Ph).
Cianciulli
Anna Maria
AM
Department of Clinical Pathology, Cytogenetic Unit, Regina Elena Cancer Institute, Rome, Italy. cianciulli@ifo.it <cianciulli@ifo.it>
Marzano
Raffaella
R
Merola
Roberta
R
Orlandi
Giulia
G
Petti
M Concetta
MC
Guadagni
Fiorella
F
Pisani
Francesco
F
D000328:Adult; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D015466:Leukemia, Myeloid, Chronic-Phase / Q000235:genetics*; D010677:Philadelphia Chromosome