title: Cytochrome P4501A1 polymorphisms in the Amerindian and Mestizo populations of Mexico.
abstract: Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 polymorphic sites (position 4889 and 6235) in a group of 212 unrelated healthy individuals belonging to three different Mexican populations (106 Mexican Mestizos, 52 Teenek and 54 Mayos). Comparison among Mexican populations showed increased frequency of the *Ile allele (A on position 4889) in Mexican Mestizos when compared to Amerindians (p < 0.05). The analysis of position 6235 showed increased frequencies of *m2 (C in this position) allele in Teenek when compared to Mestizos and Mayos (p < 0.05) and of *m2/*m2 genotype when compared to Mestizos (p < 0.05). Amerindian populations (from Mexico and South America) presented the lowest frequencies of *Ile (position 4889) and *m1 (position 6235) alleles, however these frequencies vary according to the ethnic group studied. Mexican Amerindian groups together with other South Amerindian populations showed the highest frequencies for *Val at position 4889 and the *m2 allele at position 6235. The present study corroborates the high frequencies of*Val and *m2 alleles in the Amerindian populations and detects some differences between Mexican populations that correlate with linguistic differences. Our data could be helpful in understanding the distribution of these polymorphisms and in clarifying their roles as genetic and evolution markers in Amerindian populations.
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
authors.forename: Teresa
authors.initials: T
authors.lastname: Juárez-Cedillo
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Hernández-Pacheco
authors.forename: Erick
authors.initials: E
authors.lastname: Ramírez
authors.forename: Joaquín
authors.initials: J
authors.lastname: Zuñiga
authors.forename: Raul
authors.initials: R
authors.lastname: Izaguirre
authors.forename: Aurora
authors.initials: A
authors.lastname: de la Peña
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
mesh_terms: D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D007802:Language; D008800:Mexico; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D019363:Cytochrome P-450 CYP1A1