title: Determination of susceptibilities of 26 Leptospira sp. serovars to 24 antimicrobial agents by a broth microdilution technique.
abstract: The MICs of 24 antimicrobials for 26 Leptospira spp. serovars were determined using a broth microdilution technique. The MICs at which 90% of isolates tested were inhibited (MIC(90)s) of cefepime, imipenem-cilastatin, erythromycin, clarithromycin, and telithromycin were all </=0.01 microg/ml. The MIC(90)s of amoxicillin, aztreonam, cefdinir, chloramphenicol, and penicillin G were >/=3.13 microg/ml. Many antimicrobials have excellent in vitro activity against Leptospira.
authors.affiliation: Infectious Disease (MCHE-MDI), Brooke Army Medical Center, 3851 Roger Brooke Dr., Fort Sam Houston, TX 78234, USA.
authors.forename: Clinton K
authors.initials: CK
authors.lastname: Murray
authors.forename: Duane R
authors.initials: DR
authors.lastname: Hospenthal
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology; D007919:Leptospira / Q000187:drug effects*; D007922:Leptospirosis / Q000382:microbiology*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents