title: A new precursor for the preparation of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling.
abstract: For the electrophilic preparation of 6-[18F]fluoro-L-m-tyrosine ([18F]FMT), a PET tracer for measuring changes in dopaminergic function in movement disorders, a novel precursor, N-(tert-butoxycarbonyl)-3-(tert-butoxycarbonyloxy)-6-trimethylstannnyl-L-phenylalanine ethyl ester, was synthesized in four steps and 26% yield starting from L-m-tyrosine. [18F]FMT produced by two methods at two institutions was comparable in both radiochemical yield, 25-26%, and quality (chemical, enantiomeric, and radiochemical purity and specific activity) as that obtained with the original N-trifluoroacetyl-3-acetyl-6-trimethylstannyl-L-m-tyrosine ethyl ester [18F]FMT precursor.
authors.affiliation: Department of Nuclear Medicine and Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors.forename: Henry F
authors.initials: HF
authors.lastname: VanBrocklin
authors.forename: Milen
authors.initials: M
authors.lastname: Blagoev
authors.forename: Alexander
authors.initials: A
authors.lastname: Hoepping
authors.forename: James P
authors.initials: JP
authors.lastname: O'Neil
authors.forename: Manuela
authors.initials: M
authors.lastname: Klose
authors.forename: Pius A
authors.initials: PA
authors.lastname: Schubiger
authors.forename: Simon
authors.initials: S
authors.lastname: Ametamey
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification*; D007553:Isotope Labeling / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000302:isolation & purification; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C080704:6-fluoro-3-tyrosine; D014443:Tyrosine