title: ACE1 polymorphism and progression of SARS.
abstract: We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p=0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.
authors.affiliation: Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Itoyama
authors.forename: Naoto
authors.initials: N
authors.lastname: Keicho
authors.forename: Tran
authors.initials: T
authors.lastname: Quy
authors.forename: Nguyen Chi
authors.initials: NC
authors.lastname: Phi
authors.forename: Hoang Thuy
authors.initials: HT
authors.lastname: Long
authors.forename: Le Dang
authors.initials: LD
authors.lastname: Ha
authors.forename: Vo Van
authors.initials: VV
authors.lastname: Ban
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.forename: Minako
authors.initials: M
authors.lastname: Hijikata
authors.forename: Ikumi
authors.initials: I
authors.lastname: Matsushita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawana
authors.forename: Hideki
authors.initials: H
authors.lastname: Yanai
authors.forename: Teruo
authors.initials: T
authors.lastname: Kirikae
authors.forename: Tadatoshi
authors.initials: T
authors.lastname: Kuratsuji
authors.forename: Takehiko
authors.initials: T
authors.lastname: Sasazuki
mesh_terms: D018450:Disease Progression; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D000860:Hypoxia / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011024:Pneumonia, Viral / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D011110:Polymorphism, Genetic; D045169:Severe Acute Respiratory Syndrome / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics*; D014744:Vietnam / Q000453:epidemiology
chemical_list: D007703:Peptidyl-Dipeptidase A