Screening study for potential lead compounds for natural product-based fungicides: I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea.
An efficient, one-pot synthesis of angular and linear dihydropyranocoumarins, along with C-6 and C-8 prenylated coumarins is reported. These compounds, together with single- and furanocoumarins, were tested for their potential antifungal activity against the phytopathogen Botrytis cinerea Pers ex Fr. The results show that furanocoumarins may be able to control the fungus B cinerea.
Daoubi
Mourad
M
Laboratoire de Chimie des Substances Naturelles et Hétérocycles, Université Cadi Ayyad, Faculté des Sciences Semlalia, BP 2390, Marrakech, Marocco.
Durán-Patrón
Rosa
R
Hmamouchi
Mohamed
M
Hernández-Galán
Rosario
R
Benharref
Ahmed
A
Collado
Isidro G
IG
D001685:Biological Factors / Q000138:chemical synthesis / Q000633:toxicity*; D020171:Botrytis / Q000187:drug effects*; D003374:Coumarins / Q000138:chemical synthesis / Q000633:toxicity*; D046508:Culture Techniques; D005659:Fungicides, Industrial / Q000138:chemical synthesis / Q000633:toxicity*; D011564:Furocoumarins / Q000138:chemical synthesis / Q000633:toxicity; D010572:Pest Control, Biological / Q000379:methods*; D017368:Protein Prenylation
D001685:Biological Factors; D003374:Coumarins; D005659:Fungicides, Industrial; D011564:Furocoumarins