title: Maternal colonisation with group B streptococcus and effectiveness of a culture-based protocol to prevent early-onset neonatal sepsis.
abstract: This study was conducted to find out the group B streptococcus colonisation of pregnant women in Kocaeli, Turkey. A culture plus individualised high-risk-based antibiotic prophylaxis was compared with high-risk-based approach alone. The screening of women was performed via vaginal and anal cultures for group B streptococcus (GBS). The maternal GBS colonisation rate was found to be 6.5%. All colonised women or preterm labours with unavailable culture results until delivery received prophylactic antibiotics. Neonatal colonisation rate and early-onset neonatal sepsis due to GBS was 1/200. The unscreened 900 women received prophylactic antibiotics due to a risk factor-based approach. The neonatal colonisation rate was 17/900 (p = 0.1), and the rate of early-onset neonatal sepsis was 3/900 (p = 0.6). A culture plus individualised high-risk-based antibiotic prophylaxis provided an insignificant change in neonatal colonisation and early-onset neonatal sepsis with GBS when compared with high-risk-based approach alone.
authors.affiliation: Department of Obstetrics and Gynaecology, Kocaeli University, Faculty of Medicine Kocaeli, Turkey. gulserene@superonline.com
authors.forename: G
authors.initials: G
authors.lastname: Yücesoy
authors.forename: E
authors.initials: E
authors.lastname: Calişkan
authors.forename: A
authors.initials: A
authors.lastname: Karadenizli
authors.forename: A
authors.initials: A
authors.lastname: Corakçi
authors.forename: I
authors.initials: I
authors.lastname: Yücesoy
authors.forename: N
authors.initials: N
authors.lastname: Hüseyinoğlu
authors.forename: K
authors.initials: K
authors.lastname: Babaoğlu
mesh_terms: D000328:Adult; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D018805:Sepsis / Q000517:prevention & control*; D013290:Streptococcal Infections / Q000517:prevention & control*; D013292:Streptococcus agalactiae