title: Allergens in Japanese patients with allergic conjunctivitis in autumn.
abstract: OBJECTIVE
  The purpose of the current study is to evaluate the relation between various specific class E immunoglobulins (IgE) in the serum and allergic conjunctivitis in autumn.
  
  
  METHODS
  Total IgE and specific IgE to 12 inhalant allergens were measured using the CAP system in 32 patients with allergic conjunctivitis in spring (spring group), 27 patients with allergic conjunctivitis in autumn (autumn group), and 40 healthy volunteers (control group).
  
  
  RESULTS
  Specific IgE levels caused by house dust, Dermatophagoides pteronyssinus, and orchard grass were higher in the autumn group than in the spring group. The highest positivity rate for a specific allergen was 51.9% for house dust, followed by D. pteronyssinus(48.1%) in the autumn group, while the highest rate was 68.8 % for cedar pollen, followed by cypress pollen (59.4%) in the spring group. Correlation analysis showed that house dust was significantly correlated with animal epithelia, D. pteronyssinus, acarus, and Alternaria tenuis in the autumn group (P<0.001).
  
  
  CONCLUSIONS
  These results suggest that house dust is the main cause of allergic conjunctivitis during autumn. In spring, cypress pollen is the largest cause of allergic conjunctivitis, while indoor allergens such as house dust, animal epithelia, D. pteronyssinus, and acarus are not causative allergens in Japan.
authors.affiliation: Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan. mimura@mbg.ocn.ne.jp
authors.forename: T
authors.initials: T
authors.lastname: Mimura
authors.forename: S
authors.initials: S
authors.lastname: Yamagami
authors.forename: S
authors.initials: S
authors.lastname: Amano
authors.forename: H
authors.initials: H
authors.lastname: Funatsu
authors.forename: A
authors.initials: A
authors.lastname: Arimoto
authors.forename: T
authors.initials: T
authors.lastname: Usui
authors.forename: K
authors.initials: K
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Araie
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology*; D000918:Antibody Specificity; D039741:Antigens, Dermatophagoides / Q000276:immunology; D003233:Conjunctivitis, Allergic / Q000276:immunology*; D040002:Dermatophagoides pteronyssinus / Q000276:immunology; D004391:Dust / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000276:immunology; D011852:Radioallergosorbent Test; D012621:Seasons
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D004391:Dust; D007073:Immunoglobulin E