title: MOP-UP: an online tool for finding strain-specific primers or motifs in DNA or protein alignments.
abstract: MOP-UP is a web-based application that enables efficient searching of nucleic acid or amino-acid alignments for sequences or motifs that are unique to a subset of the members represented in the alignment. This has applications in the design of assays that aim to detect particular strains or species. Since molecular-based characterisation of microbes is becoming increasingly important, MOP-UP can aid microbiologists in finding the best loci on which to base such assays. The program is accessible at: http://www.hpa.org.uk/srmd/bioinformatics/tools/mop-ups.htm.
authors.affiliation: Central Public Health Laboratory, Genomics, Proteomics and Bioinformatics Unit, London, UK. anthony.underwood@hpa.org.uk
authors.forename: A P
authors.initials: AP
authors.lastname: Underwood
authors.forename: J
authors.initials: J
authors.lastname: Green
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D017931:DNA Primers / Q000737:chemistry; D020407:Internet; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods; D020539:Sequence Analysis, Protein / Q000379:methods
chemical_list: D017931:DNA Primers