Adsorption of a blood protein on to hydrophilic sponges based on poly(2-hydroxyethyl methacrylate).
Spongy materials of poly(2-hydroxyethyl methacrylate) were synthesized and the adsorption of bovine serum albumin was carried out onto their surfaces. The sponges were characterized by IR spectral analysis, and water sorption property. It was noticed that the chemical architecture of the sponge has a pronounced impact on both the water sorption capacity and adsorption affinity of the sponge surfaces. The adsorption was also studied kinetically and the effect of pH was also investigated. The synthesized sponges were evaluated for antithrombogenic property by performing blood-clot formation tests.
Bajpai
A K
AK
Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur (M.P.) - 482 001, India. akbmrl@yahoo.co.in
Mishra
D D
DD
D000042:Absorption; D000327:Adsorption; D001777:Blood Coagulation / Q000187:drug effects*; D001798:Blood Proteins / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D004058:Diffusion; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008968:Molecular Conformation; D009995:Osmosis; D044367:Phase Transition; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000494:pharmacology; D014867:Water / Q000737:chemistry*
D001798:Blood Proteins; D020099:Coated Materials, Biocompatible; D014867:Water; D011102:Polyhydroxyethyl Methacrylate; D012710:Serum Albumin, Bovine