N- t-Boc-amino acid esters of isomannide. Potential inhibitors of serine proteases.
Hepatitis C, Dengue and West Nile virus are some of the most important flaviviruses, that share one important serine protease enzyme. Serine proteases are the most studied class of proteolytic enzyme and, in these cases, a primary target for drug discovery. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N- t-Boc amino acid esters derived of isomannide as potential serine proteases inhibitors.
Muri
E M F
EM
Instituto de Química, UFRJ, Cidade Universitária, CT Bloco A, Rio de Janeiro, Brazil.
Gomes
M
M
Costa
J S
JS
Alencar
F L
FL
Sales
A
A
Bastos
M L
ML
Hernandez-Valdes
R
R
Albuquerque
M G
MG
da Cunha
E F F
EF
Alencastro
R B
RB
Williamson
J S
JS
Antunes
O A C
OA
D000596:Amino Acids / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D003716:Dengue Virus / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005416:Flavivirus / Q000378:metabolism; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008353:Mannitol / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation; D012697:Serine Endopeptidases / Q000737:chemistry*; D013696:Temperature; D017361:Viral Nonstructural Proteins / Q000737:chemistry
C502182:1,4-3,6-dianhydromannitol; D000596:Amino Acids; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D010455:Peptides; D017361:Viral Nonstructural Proteins; D008353:Mannitol; D002244:Carbon; D012697:Serine Endopeptidases; D008358:Mannose