title: Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay.
abstract: Three new macrocyclic diterpenes, kansuinins F (1), G (2), and H (3), together with four known jatrophane diterpenes, kansuinins D (4), E (5), and A (6) and 3beta,5alpha,7beta,15beta-tetraacetoxy-9alpha-nicotinoyloxyjatropha-6(17)-11E-dien-14-one, were isolated from the roots of Euphorbia kansui. Compounds 1 and 2 were assigned as 6(17)-en-11,12-epoxy-14-one-type jatrophane diterpenes, and compound 3 as a 6(17)-en-11,14-epoxy-12-one jatrophane diterpene. The structures of compounds 1-3 and the relative configurations of compounds 4 and 5 were determined by spectral data analysis. Kansuinin E (5) exhibited a specific survival effect on fibroblasts that expressed TrkA, a high-affinity receptor for nerve growth factor.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Pan
authors.forename: Fanny C F
authors.initials: FC
authors.lastname: Ip
authors.forename: Nancy Y
authors.initials: NY
authors.lastname: Ip
authors.forename: Hua-Xu
authors.initials: HX
authors.lastname: Zhu
authors.forename: Zhi-Da
authors.initials: ZD
authors.lastname: Min
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D005347:Fibroblasts / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D020917:Receptor, trkA / Q000187:drug effects
chemical_list: D004224:Diterpenes; D020932:Nerve Growth Factor; D020917:Receptor, trkA