[Hydro-cellular dressing and silver sulfadiazine. Evaluation of its combination in the treatment of infected skin ulcers].
The authors carried out an observational, descriptive, prospective and multi-centric study on 49 infected lesions which had clinical signs of local infection as well as infection from a positive sprinkler method culture. These lesions were treated over a three week period with argentic sulfadiazine and a semi-permeable dressing; afterward, treatment continued for seven weeks more based on cures in a humid environment by means of a semi-permeable dressing. After three weeks of treatment, two-thirds of these lesions showed a negative exudative culture, the number of strains present in the rest of the cultures diminished to at least half of those present at the start of this study. 15 of these lesions completely closed over during the period of study (mean = 46.73 +/- 22.74 days) and the absolute cicatrisation surface area varied, on average, from 23.46 square cm at the start to 12.39 square cm at the end of this study. In relation to the relative cicatrisation an average reduction of 76.5% (IC 95= (66.85% - 86.2%)) occurred. Variance analysis (ANOVA) over repeated measurements established significant differences (p = 0.001) having a tendency toward a lineal decrease. The authors also found statistically significant differences regarding the mean relative cicatrisation in the subgroup having lesions which stopped being infected during the third week of treatment when compared to those lesions which continued being infected. In conclusion, the authors state the topical treatment using argentic sulfadiazine in combination with a semi-permeable dressing has been favorable in treating two of every three lesions which stopped being infected in the third week of treatment, furthermore, this treatment produced a reduction in the size of these lesions, both in terms of the absolute mean cicatrisation area as in the relative mean cicatrisation area cicatrisation area for the lesion group in this study.
Martínez Cuervo
Fernando
F
Hospital de La Rioja.
Soldevilla Agreda
Javier
J
Verdú Soriano
José
J
Germán Torres de Castro
Oscar
O
García Toro
Manuel
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D011446:Prospective Studies; D012837:Silver Sulfadiazine / Q000008:administration & dosage*; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D012883:Skin Ulcer / Q000188:drug therapy* / Q000382:microbiology*
D000891:Anti-Infective Agents, Local; D012837:Silver Sulfadiazine
Apósito hidro celular sulfadiacina argéntica. Evaluación de su combinación en el tratamiento de úlceras cutáneas infectadas.