title: Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study.
abstract: A high prevalence of abnormal cavum septi pellucidi (CSP) in schizophrenia may reflect neurodevelopmental abnormalities in midline structures of the brain. The relationship, however, between abnormal CSP and clinical symptoms, and with abnormalities in other limbic structures remains unclear, as does the question of whether a similar abnormality is present in affective psychosis. Seventy-four patients at their first hospitalization, 33 with schizophrenia and 41 with affective (mainly manic) psychosis, and 56 healthy control subjects underwent high-spatial-resolution magnetic resonance imaging (MRI). CSP on six slices or more on 0.9375-mm resampled coronal images was categorized as abnormal. The prevalence of abnormal CSP in both schizophrenic patients (26.1%) and affective psychosis patients (18.2%) was significantly higher than was observed in control subjects (8.2%). In schizophrenic patients only, larger CSP was significantly associated with more severe thinking disturbance and smaller left parahippocampal gyrus gray matter volumes. While the relationships between CSP ratings and clinical symptoms did not significantly differ between the two psychosis groups as assessed by the comparison of regression slopes, the association with limbic volumes appeared to be specific to schizophrenic patients. These results suggest that psychosis associated with schizophrenia and affective disorder share, at least to some extent, neurodevelopmental abnormalities involving midline structures and associated psychopathological consequences. However, the association between abnormal CSP and limbic systems may be more specific to schizophrenia.
authors.affiliation: Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, 940 Belmont St., Brockton, MA 02301, USA.
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Robert W
authors.initials: RW
authors.lastname: McCarley
authors.forename: Dean F
authors.initials: DF
authors.lastname: Salisbury
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Onitsuka
authors.forename: Susan
authors.initials: S
authors.lastname: Demeo
authors.forename: Deborah
authors.initials: D
authors.lastname: Yurgelun-Todd
authors.forename: Ron
authors.initials: R
authors.lastname: Kikinis
authors.forename: Ferenc A
authors.initials: FA
authors.lastname: Jolesz
authors.forename: Martha E
authors.initials: ME
authors.lastname: Shenton
mesh_terms: D000293:Adolescent; D000328:Adult; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006760:Hospitalization; D006801:Humans; D008032:Limbic System / Q000002:abnormalities / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis / Q000503:physiopathology*; D020534:Parahippocampal Gyrus / Q000002:abnormalities / Q000503:physiopathology; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology*; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology* / Q000534:rehabilitation; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000503:physiopathology*