title: Paxillin: adapting to change.
abstract: Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in cell migration and gene expression.
authors.affiliation: Dept. of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Brown
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Turner
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D051419:Paxillin; D010750:Phosphoproteins / Q000737:chemistry* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D003598:Cytoskeletal Proteins; D006133:Growth Substances; D016023:Integrins; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins