title: Reduced plasma membrane Ca2+-ATPase function in platelets from patients with non-insulin-dependent diabetes mellitus.
abstract: We clearly show that plasma membrane Ca2+ ATPase (PMCA) activity is lower in platelets from patients with non-insulin-dependent diabetes mellitus (NIDDM) than in those from healthy controls. The lower activity is likely due to reduced PMCA expression and increased tyrosine phosphorylation. These findings provide an explanation for the cellular ionic defects occurring in insulin resistant conditions.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Rosado
authors.forename: Francisco Raúl
authors.initials: FR
authors.lastname: Saavedra
authors.forename: Pedro Cosme
authors.initials: PC
authors.lastname: Redondo
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Hernández-Cruz
authors.forename: Ginés María
authors.initials: GM
authors.lastname: Salido
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Pariente
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D002118:Calcium / Q000097:blood; D000252:Calcium-Transporting ATPases / Q000097:blood / Q000737:chemistry / Q000172:deficiency*; D027682:Cation Transport Proteins / Q000097:blood / Q000737:chemistry / Q000172:deficiency*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000201:enzymology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015759:Ionomycin / Q000494:pharmacology; D008297:Male; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000032:analysis; D053499:Plasma Membrane Calcium-Transporting ATPases; D015539:Platelet Activation; D011499:Protein Processing, Post-Translational; D019284:Thapsigargin / Q000494:pharmacology
chemical_list: D027682:Cation Transport Proteins; D019000:Phosphotyrosine; D015759:Ionomycin; D019284:Thapsigargin; D053499:Plasma Membrane Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases; D002118:Calcium