title: Current immunosuppressive agents in pediatric renal transplantation: efficacy, side-effects and utilization.
abstract: Advances in immunosuppressive therapy over the past decade have led to dramatic improvements in graft survival. The immunosuppression that is used is center-dependent and is constantly evolving with the development of new medications. The goal remains to find the best combination that will optimize graft survival, while minimizing the adverse effects.
authors.affiliation: Division of Nephrology, Children's Hospital and Regional Medical Center, University of Washington, 4800 Sand Point Way, Seattle, WA 98105, USA. jodi.smith@seattlechildrens.org
authors.forename: Jodi M
authors.initials: JM
authors.lastname: Smith
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Nemeth
authors.forename: Ruth A
authors.initials: RA
authors.lastname: McDonald
mesh_terms: D000208:Acute Disease; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D000077561:Daclizumab; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation; D016853:Muromonab-CD3 / Q000009:adverse effects / Q000627:therapeutic use; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020123:Sirolimus / Q000009:adverse effects / Q000627:therapeutic use; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D016853:Muromonab-CD3; D016572:Cyclosporine; D000077561:Daclizumab; D009173:Mycophenolic Acid; D001379:Azathioprine; D020123:Sirolimus; D016559:Tacrolimus