Control of mRNA translation and stability in haematopoietic cells: the function of hnRNPs K and E1/E2.
Studies on the post-transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH-domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA-protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.
Ostareck-Lederer
Antje
A
Department of Biochemistry and Biotechnology, Institute of Biochemistry, Martin-Luther-University, Kurt-Mothes-Str. 3, 06120 Halle (Saale), Germany.
Ostareck
Dirk H
DH
D001093:Arachidonate 15-Lipoxygenase / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D004920:Erythropoiesis / Q000502:physiology; D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D034641:Heterogeneous-Nuclear Ribonucleoprotein K / Q000378:metabolism*; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000378:metabolism*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D012156:Reticulocytes / Q000378:metabolism
D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012333:RNA, Messenger; D005914:Globins; D001093:Arachidonate 15-Lipoxygenase