title: Tritium in [18O]water containing [18F]fluoride for [18F]FDG synthesis.
abstract: The presence of tritium in enriched [18O]water irradiated with 9.6 MeV protons used to produce [18F]fluoride by the 18O(p, n)18F reaction was inferred from the cross sections and threshold energies of the 18O(p, t)16O reaction, and the existence of tritium was confirmed experimentally. Tritium was also detected in both [18O]water recovered for recycling and waste acetonitrile solutions. The purified [18F]FDG was not contaminated with 3H. The amount of 3H discharged into the air was far less than the International Basic Safety Standard Level.
authors.affiliation: Radioisotope Research Center and Graduate School of Environmental Studies, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Ito
authors.forename: Takuya
authors.initials: T
authors.lastname: Saze
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sakane
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ito
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ito
authors.forename: Kunihide
authors.initials: K
authors.lastname: Nishizawa
mesh_terms: D004340:Drug Contamination / Q000517:prevention & control; D005462:Fluorine Radioisotopes / Q000032:analysis* / Q000737:chemistry*; D019788:Fluorodeoxyglucose F18 / Q000032:analysis* / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D010103:Oxygen Isotopes / Q000032:analysis / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000032:analysis / Q000737:chemistry; D014316:Tritium / Q000032:analysis* / Q000737:chemistry*; D014867:Water / Q000032:analysis* / Q000737:chemistry
chemical_list: D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D014867:Water; D019788:Fluorodeoxyglucose F18; D014316:Tritium