The risk of lymphoma in AKR/J mice does not rise with chronic exposure to 50 Hz magnetic fields (1 microT and 100 microT).
Some epidemiological studies suggest that exposure to 50 or 60 Hz magnetic fields might increase the risk of leukemia, especially in children with a comparable high residential exposure. To investigate this possibility experimentally, the influence of 50 Hz magnetic-field exposure on lymphoma induction was determined in a mouse strain that is genetically predisposed to this disease. The AKR/J mouse genome carries the AK virus, which leads within 1 year to spontaneous development of thymic lymphoblastic lymphoma. Beginning at an age of 4-5 weeks, groups of 160 female mice were sham-exposed or exposed to 50 Hz magnetic fields at 1 or 100 microT for 24 h per day, 7 days per week, for 38 weeks. Animals were checked visually daily and were weighed and palpated weekly. There was no effect of magnetic-field exposure on body weight gain or survival rate, and lymphoma incidence did not differ between exposed and sham-exposed animals. Therefore, these data do not support the hypothesis that chronic exposure to 50 Hz magnetic fields is a significant risk factor for developing hematopoietic malignancy.
Sommer
Angela M
AM
School of Engineering and Science, International University Bremen, Bremen, Germany.
Lerchl
Alexander
A
D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005260:Female; D015994:Incidence; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology*; D008280:Magnetics; D051379:Mice; D010100:Oxygen / Q000378:metabolism; D012307:Risk Factors
D010100:Oxygen