Cytomegalovirus prevalence and transmission after islet allograft transplant in patients with type 1 diabetes mellitus.
Cytomegalovirus (CMV) serological status of transplant donors and recipients has important implications on antiviral prophylaxis, morbidity/mortality, donor selection and hospital stay. We evaluated CMV prevalence in our islet transplant candidates (ITC) in comparison with organ donors. We correlated the CMV serological status of our ITC with serology for Epstein-Barr virus and Parvovirus B19, auto-antibodies, patient's age, age at DM onset, duration of DM, gender, race, ABO group, HLA haplotype and C-peptide levels. Cytomegalovirus transmission after islet transplant using the Edmonton regimen was also evaluated. Cytomegalovirus seropositivity varied according to patient group, age, gender and race. Type 1 DM patients had reduced odds of CMV seropositivity when compared with organ donors. In all groups studied, older patients, females, and non-Caucasians were more likely to be CMV seropositive. In addition, no CMV reactivation, infection or disease was observed among our transplanted patients using this steroid-free regimen even after donor/recipient CMV mismatch.
Hafiz
Muhammad M
MM
Diabetes Research Institute, University of Miami School of Medicine, Miami, FL, USA.
Poggioli
Raffaella
R
Caulfield
Aileen
A
Messinger
Shari
S
Geiger
Milene C
MC
Baidal
David A
DA
Froud
Tatiana
T
Ferreira
Jacqueline V
JV
Tzakis
Andreas G
AG
Ricordi
Camillo
C
Alejandro
Rodolfo
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery* / Q000821:virology; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D014019:Tissue Donors