title: [Importance of microcirculation in plastic surgery].
abstract: The article summarizes distinct microcirculatory models for use in surgical research with a special interest to plastic surgery. Methods for the quantitative analysis of the microcirculation in burns, flaps and wounds are presented. Vascularization of biomaterials can be observed by means of the dorsal skinfold chamber model in hamsters and mice. Developing capillary sprouts can be assessed by means of videomicroscopy and angiogenetic drugs can be tested using this model. Hairless mice allow for direct, long-term observation of the microcirculation in burns as well as during healing of dermal wounds. The pathophysiology of diabetic wound healing can also be studied. A mouse model to assess flap microcirculation during ischemia/reperfusion injury with special emphasis on platelet/endothelium interaction in vivo is described. Platelets adherent to the inner vessel wall are known to trigger compromised perfusion in flaps. The model allows us to test anti-thrombotic drugs. The use of a special microscopic device (OPS imaging) allows us to study the microcirculation at sites of burn injury and chronic wounds in humans. Microcirculatory research in plastic surgery has increased the understanding of the pathophysiology of vascularization of biomaterials, wound healing and ischemia/reperfusion.
authors.affiliation: Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte -- Handchirurgiezentrum, BG-Kliniken Bergmannsheil, Ruhr-Universität Bochum. Stefan.Langer@ruhr-uni-bochum.de
authors.forename: S
authors.initials: S
authors.lastname: Langer
authors.forename: T
authors.initials: T
authors.lastname: Galla
authors.forename: H U
authors.initials: HU
authors.lastname: Steinau
authors.forename: H H
authors.initials: HH
authors.lastname: Homann
authors.forename: D
authors.initials: D
authors.lastname: Druecke
authors.forename: R
authors.initials: R
authors.lastname: Hatz
authors.forename: D
authors.initials: D
authors.lastname: Nolte
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000502:physiology; D002056:Burns / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D015815:Cell Adhesion Molecules / Q000502:physiology; D002908:Chronic Disease; D004195:Disease Models, Animal; D005453:Fluorescence; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D008812:Mice, Hairless; D008807:Mice, Inbred BALB C; D008833:Microcirculation; D008853:Microscopy; D018919:Neovascularization, Physiologic; D019651:Plastic Surgery Procedures; D015427:Reperfusion Injury / Q000503:physiopathology; D013518:Surgery, Plastic; D013524:Surgical Flaps; D023822:Tissue Engineering; D014180:Transplantation; D014945:Wound Healing / Q000502:physiology; D014947:Wounds and Injuries / Q000175:diagnosis* / Q000503:physiopathology*
chemical_list: D001672:Biocompatible Materials; D015815:Cell Adhesion Molecules
vernacular_title: Die Bedeutung der Mikrozirkulation in der Plastischen Chirurgie.