Synaptic and extrasynaptic neurotransmitter receptors in glial precursors' quest for identity.
It is widely established that neurotransmitter receptors are expressed in non-neuronal cells, and particularly in neural progenitor cells in the postnatal central nervous system. The functional role of these receptors during development is unclear, but it needs to be revisited now that cells previously considered restricted to glial lineages have been shown to generate neurons. The present review integrates recent advances, to shed new light on how neurotransmitter receptors may, alternatively, serve as excitable mediators of neuron-glia and neuron-neuroblast interactions.
Belachew
Shibeshih
S
Center for Cellular and Molecular Neurobiology, University of Liège, Liège, Belgium.
Gallo
Vittorio
V
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development / Q000502:physiology; D006801:Humans; D009457:Neuroglia / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D017981:Receptors, Neurotransmitter