Phenotypic selection for residual feed intake and its effect on humoral immune responses in growing layer hens.
According to the resource allocation theory, animals have to make a trade-off between resource-demanding life traits to obtain maximal fitness. Artificial selection toward efficient producing farm animals, however, may have created animals that have an impaired ability to divert resources to maintenance processes, such as responding to immune challenges. Residual feed intake (RFI), defined as the difference between observed feed intake (FI) and expected feed intake based on metabolic BW and growth, was used as a measure for feed efficiency. Individual BW and FI of 352 pullets were recorded weekly from 4 until 14 wk of age to estimate RFI. The top 50 efficient R- and the top 50 nonefficient R+ birds were selected. BW and BW gain in both groups were similar. FI and RFI, however, were significantly higher in R+ birds. Thirty animals out of every group were randomly allocated to 1 of 3 treatments: immunization with keyhole limpet hemocyanin (KLH), Mycobacterium butyricum, or heat-inactivated Salmonella enteritidis bacteria. Antibody titers against KLH, M. butyricum, or Salmonella lipopolysaccharide did not differ between R+ and R- birds. The antibody titer against Salmonella protein was higher in R+ birds. We concluded that a population of chickens from a commercial breed shows considerable variation in RFI. Specific antibody production against KLH, M. butyricum, and S. enteritidis lipopolysaccharide, however, is not influenced by efficiency in terms of RFI. R+ animals may have a higher level of nonantigen specific antibodies, as indicated by the higher antibody response to Salmonella protein.
Van Eerden
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Adaptation Physiology Group, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands. Ellen.VanEerden@wur.nl
Van Den Brand
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Parmentier
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De Jong
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MC
Kemp
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D000821:Animal Feed; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D000917:Antibody Formation / Q000502:physiology; D002645:Chickens / Q000276:immunology*; D004435:Eating / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006128:Growth / Q000276:immunology*; D006433:Hemocyanins / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D009161:Mycobacterium / Q000276:immunology*; D010641:Phenotype; D012477:Salmonella enteritidis / Q000276:immunology*; D012641:Selection, Genetic
D000907:Antibodies, Bacterial; D008070:Lipopolysaccharides; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin