Protective roles of CNS mitochondria.
Mitochondria benefit their host cells by generating ATP, detoxifying oxygen, maintaining cellular redox potential, and detoxifying reactive oxygen species and xenobiotics. These beneficial roles are in stark contrast to mitochondrial participation in both necrotic and apoptotic degenerative pathways. However, cellular stresses do not always result in deleterious mitochondrial changes. Decreases in the calcium sensitivity of the permeability transition may be initial mitochondrial responses to stress that act to preserve mitochondrial function and prolong normal functioning of the host cell.
Dubinsky
Janet M
JM
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA. dubin001@umn.edu
Brustovetsky
Nickolay
N
LaFrance
Reghann
R
D000222:Adaptation, Physiological; D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002463:Cell Membrane Permeability; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*
D015220:Calcium Channels; D033681:Mitochondrial Membrane Transport Proteins; D002118:Calcium