title: [Redox homeostasis in inflammatory bowel diseases].
abstract: Janus faced oxygen radicals are secondary messengers of intracellular signal transduction pathways but also cytotoxic agents of cells. Activation of signal transduction proteins on mild oxidant stress and metal elements are still not clearly understood. Oxygen free radicals may have several functions in the expression of cytokines associated with inflammatory bowel disease. The molecular mechanism between activation, and inhibition participants of signal transduction are delicately controlled. Antioxidant-prooxidant balance of the cells can be traced back to the concentration of free-SH and its oxidised form,-S-S-. Healthy erythrocytes and plasma are rich in antioxidants, but their type of protection, differs significantly. The balance of free radicals and antioxidants is disturbed in inflammatory bowel disease. The antioxidant defence mechanism depends on concentration of metal elements, which determines enzyme activities. It seems that nutritional supplementation and adequate therapy restore the ion homeostasis, although, Zn overdose may cause disturbance in iron metabolism and consequently may influence erythrocyte functions.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest.
authors.forename: Anna
authors.initials: A
authors.lastname: Blázovics
authors.forename: Klára
authors.initials: K
authors.lastname: Szentmihályi
authors.forename: László
authors.initials: L
authors.lastname: Prónai
authors.forename: Krisztina
authors.initials: K
authors.lastname: Hagymási
authors.forename: Andrea
authors.initials: A
authors.lastname: Lugasi
authors.forename: Agota
authors.initials: A
authors.lastname: Kovács
authors.forename: János
authors.initials: J
authors.lastname: Fehér
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D015179:Colorectal Neoplasms / Q000209:etiology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000150:complications / Q000378:metabolism*; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015290:Second Messenger Systems; D015398:Signal Transduction; D014131:Trace Elements / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016207:Cytokines; D017382:Reactive Oxygen Species; D014131:Trace Elements; D014157:Transcription Factors; D015032:Zinc
vernacular_title: Redox-homeosztázis gyulladásos bélbetegségekben.