title: Malignant tumours of the minor salivary glands--a 20 year review.
abstract: The UK incidence of malignant disease of the minor salivary glands is only 0.6 per million per year. The tumours have a varied histology, can present in any age group and are frequently advanced if located in the sinonasal cavities. In a 20-year review of 21 patients treated for minor salivary gland malignancy in a single institution, it was found that mucoepidermoid tumours were more common in the oral cavity and adenoid cystic carcinomas in the sinonasal tract (p = 0.002). Outcome was variable with sinonasal and adenoid cystic carcinoma having a poorer outcome. Kaplan-Meier curves showed that oral tumours had a higher probability of long term survival. Radical surgery with reconstruction and post-operative adjuvant radiotherapy was effective in achieving loco-regional control. There were no local recurrences within 5 years and three after 5 years. Five patients developed metastatic disease within 10 years and a further two after 10 years. Late recurrences occurred and survival was mainly determined by the presence of systemic disease.
authors.affiliation: Head and Neck Unit, Department of Plastic and Reconstructive Surgery, Royal Victoria Infirmary, Queen Victoria Rd, Newcastle-upon-Tyne, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Strick
authors.forename: C
authors.initials: C
authors.lastname: Kelly
authors.forename: J V
authors.initials: JV
authors.lastname: Soames
authors.forename: N R
authors.initials: NR
authors.lastname: McLean
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012470:Salivary Glands, Minor; D014057:Tomography, X-Ray Computed / Q000379:methods