Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells.
BACKGROUND
Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists.


RESULTS
Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia.


CONCLUSIONS
G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
Shyu
Woei-Cherng
WC
Department of Neurology, Neuro-Medical Scientific Center, Tzu-Chi Buddhist General Hospital, Tzu-Chi University, Hualien, Taiwan.
Lin
Shinn-Zong
SZ
Yang
Hui-I
HI
Tzeng
Yi-Shiuan
YS
Pang
Cheng-Yoong
CY
Yen
Pao-Sheng
PS
Li
Hung
H
D000818:Animals; D015415:Biomarkers; D001853:Bone Marrow / Q000187:drug effects; D001923:Brain Chemistry; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D004261:DNA Replication; D004353:Drug Evaluation, Preclinical; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D019416:Head Movements; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology / Q000628:therapy*; D007279:Injections, Subcutaneous; D008124:Locomotion; D008297:Male; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D019718:Receptors, CXCR4 / Q000096:biosynthesis / Q000235:genetics; D020127:Recovery of Function; D015854:Up-Regulation
D015415:Biomarkers; C486264:Cxcr4 protein, rat; D019718:Receptors, CXCR4; D016179:Granulocyte Colony-Stimulating Factor