title: No major association between TGFBR1*6A and prostate cancer.
abstract: Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused by heritable factors but the search for prostate cancer susceptibility genes has thus far remained elusive. TGFBR1*6A, a common hypomorphic variant of the type I Transforming Growth Factor Beta receptor, is emerging as a tumor susceptibility allele that predisposes to the development of breast, colon and ovarian cancer. The association with prostate cancer has not yet been explored. A total of 907 cases and controls from New York City were genotyped to test the hypothesis that TGFBR1*6A may contribute to the development of prostate cancer. TGFBR1*6A allelic frequency among cases (0.086) was slightly higher than among controls (0.080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer.
authors.affiliation: Cancer Genetics Program, Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. virginia.kaklamani@prodigy.net
authors.forename: Virginia
authors.initials: V
authors.lastname: Kaklamani
authors.forename: Lisa
authors.initials: L
authors.lastname: Baddi
authors.forename: Diana
authors.initials: D
authors.lastname: Rosman
authors.forename: Junjian
authors.initials: J
authors.lastname: Liu
authors.forename: Nathan
authors.initials: N
authors.lastname: Ellis
authors.forename: Carole
authors.initials: C
authors.lastname: Oddoux
authors.forename: Harry
authors.initials: H
authors.lastname: Ostrer
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Habibul
authors.initials: H
authors.lastname: Ahsan
authors.forename: Kenneth
authors.initials: K
authors.lastname: Offit
authors.forename: Boris
authors.initials: B
authors.lastname: Pasche
mesh_terms: D030201:Activin Receptors, Type I / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human