title: Severe acute respiratory syndrome: correlation between clinical outcome and radiologic features.
abstract: OBJECTIVE
  To evaluate whether there is a correlation between the clinical outcomes and radiologic features of severe acute respiratory syndrome (SARS).
  
  
  METHODS
  The clinical, laboratory, and radiologic features of 138 patients with SARS were analyzed. Three radiologists in consensus retrospectively assessed the frontal chest radiographs obtained at presentation and during treatment (n = 2045) for the distribution (each lung was divided into upper, middle, and lower zones) and extent of lung parenchymal abnormality. Clinical end points included intensive care unit (ICU) admission and death.
  
  
  RESULTS
  Thirty-six (26.1%) patients required ICU care, and eight (5.8%) died. The patients who required ICU care and/or died had more extensive consolidation on chest radiographs obtained initially (median percentage of consolidation, 3.30%, with interquartile range [IR] of 1.70%-8.78% vs 1.70% [IR, 0%-3.30%]; P < .001) and on day 7 after fever onset (median percentage of consolidation, 15.00% [IR, 6.48%-28.73%] vs 5.00% [IR, 2.50%-7.50%]; P < .001) than did surviving patients who did not require ICU care. Patients with involvement of more than one lung zone on initial and day 7 chest radiographs were more likely to require ICU care and/or die than were those with involvement of one or fewer zones (P < .001). Patients with bilateral pneumonic changes at presentation were more likely to have an adverse outcome than were those with unilateral pneumonia (P < .001). Involvement of more than one lung zone at baseline chest radiography was an independent predictor of ICU admission and/or death (odds ratio, 3.16; 95% confidence interval: 1.07, 9.32; P = .037) after adjustments for other significant factors (ie, patient age, and baseline neutrophil count and lactate dehydrogenase level).
  
  
  CONCLUSIONS
  More extensive airspace disease at presentation is an independent predictor of adverse outcome in patients with SARS.
authors.affiliation: Department of Diagnostic Radiology and Organ Imaging, The Chinese Univ of Hong Kong, Prince of Wales Hosp, 30-32 Ngan Shing St, Shatin, Hong Kong SAR.
authors.forename: David S C
authors.initials: DS
authors.lastname: Hui
authors.forename: K T
authors.initials: KT
authors.lastname: Wong
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Antonio
authors.forename: Nelson
authors.initials: N
authors.lastname: Lee
authors.forename: Alan
authors.initials: A
authors.lastname: Wu
authors.forename: Vincent
authors.initials: V
authors.lastname: Wong
authors.forename: Winnie
authors.initials: W
authors.lastname: Lau
authors.forename: Justin C
authors.initials: JC
authors.lastname: Wu
authors.forename: L S
authors.initials: LS
authors.lastname: Tam
authors.forename: L M
authors.initials: LM
authors.lastname: Yu
authors.forename: Gavin M
authors.initials: GM
authors.lastname: Joynt
authors.forename: Sydney S C
authors.initials: SS
authors.lastname: Chung
authors.forename: Anil T
authors.initials: AT
authors.lastname: Ahuja
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D045169:Severe Acute Respiratory Syndrome / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology