title: Intravenous valproate in acute adolescent mania: a preliminary report.
abstract: This study evaluated the efficacy and tolerability of intravenous valproate in acute mania in adolescents. Five consecutive patients, meeting the study criteria, were treated with intravenous valproate. Of them, three significantly improved and one had no appreciable improvement. Two out of five patients experienced gastrointestinal and neurological side effects. This preliminary study suggests intravenous valproate is useful and safe to treat acute juvenile mania.
authors.affiliation: Central Institute of Psychiatry Kanke (PO), Ranchi-834006 Jharkhand, India. anupsy@rediffmail.com
authors.forename: Anupam
authors.initials: A
authors.lastname: Thakur
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Dutta
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Sinha
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014150:Antipsychotic Agents; D014635:Valproic Acid