title: Biaryl guanidine inhibitors of in vitro HCV-IRES activity.
abstract: A structure-activity relationship analysis was carried out on a high-throughput small molecule screening lead for HCV-IRES translation inhibition. The study led to the identification of a guanidine-based structure with low microM inhibitory activity.
authors.affiliation: Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA. ejeffers@isiph.com
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Jefferson
authors.forename: Punit P
authors.initials: PP
authors.lastname: Seth
authors.forename: Dale E
authors.initials: DE
authors.lastname: Robinson
authors.forename: Dana K
authors.initials: DK
authors.lastname: Winter
authors.forename: Alycia
authors.initials: A
authors.lastname: Miyaji
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Osgood
authors.forename: Eric E
authors.initials: EE
authors.lastname: Swayze
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Risen
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D016208:Databases, Factual; D006146:Guanidines / Q000737:chemistry*; D016174:Hepacivirus / Q000235:genetics* / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects*; D012270:Ribosomes / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects; D014764:Viral Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D000998:Antiviral Agents; D006146:Guanidines; D014764:Viral Proteins