In vitro biocompatibility of PTMO-based polyurethanes and those containing PDMS blocks.
In this work, a series of different polyurethanes based on poly(tetramethylene oxide) (PTMO, MW approximately 2000) and chain extended with butenediol were synthesized by a two-step solution polymerization. Three of them contained silanol terminated polydimethylsiloxane (PDMS, MW approximately 2000) blocks. It was shown that these polymers exhibited various degrees of micro-phase separation that further influenced their biological performances in vitro. The formulation with diphenylmethane diisocyanate/PTMO/PDMS/2-butene-1,4-diol at a molar ratio of 2: 0.75: 0.5: 1 in synthesis was favorable due to a combination of enhanced mechanical properties, biostability, cellular affinity as well as platelet nonadherence.
Hsu
Shan-Hui
SH
Department of Chemical Engineering, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung, Taiwan 402, ROC. shhsu@nchu.edu.tw
Tseng
Hsiang-Jung
HJ
D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation; D002478:Cells, Cultured; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004548:Elasticity; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008422:Materials Testing; D010087:Oxides / Q000737:chemistry*; D015539:Platelet Activation / Q000502:physiology; D010973:Platelet Adhesiveness / Q000502:physiology*; D011140:Polyurethanes / Q000737:chemistry*; D012828:Silicones / Q000737:chemistry*; D013499:Surface Properties
D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D010087:Oxides; D011140:Polyurethanes; D012828:Silicones; C404813:polytetramethyloxide; C013830:baysilon