title: Bridging the gap between therapeutic research results and physician prescribing decisions: knowledge transfer, a prerequisite to knowledge translation.
abstract: BACKGROUND
  A wide gap continues to exist between available therapeutic research results and physician's prescribing. Numerous explanations account for this gap, but one central reason is the difficulty in transferring comprehensive research information to practicing clinicians. This problem arises from information overload and the growing complexity of research findings. We propose a multistep process that can be used to develop systems to bridge this information/prescription gap. The steps include: comprehensively collecting and summarizing clinical trial reports, scoring and ranking these according to their level of evidence, exploring and synthesizing the data using meta-analyses, summarizing these results, representing them in an easily understandable form, and transmitting the overview findings to prescribers at the time they need them.
  
  
  CONCLUSIONS
  This ambitious endeavor is needed to ensure that prescribers have access to pertinent research results for use in their prescription decisions. We demonstrate in this article that there are no theoretical or technical obstacles to make the proposed system workable.
authors.affiliation: Faculté RTH Laennec, Service de Pharmacologie Clinique (EA3736), rue Guillaume Paradin, 69376, Lyon Cedex 08, France. jpb@upcl.univ-lyon1.fr
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Boissel
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Amsallem
authors.forename: Michel
authors.initials: M
authors.lastname: Cucherat
authors.forename: Patrice
authors.initials: P
authors.lastname: Nony
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Haugh
mesh_terms: D002983:Clinical Competence; D003661:Decision Support Techniques; D004346:Drug Information Services; D004358:Drug Therapy; D019317:Evidence-Based Medicine; D006801:Humans; D033181:Information Dissemination / Q000379:methods*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D012106:Research; D013997:Time Factors