New ring C-seco limonoids from Brazilian Melia azedarach and their cytotoxic activity.
A methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Parana, Brazil, afforded seven new ring C-seco limonoids (1-7) together with three known limonoids (8-10). The structures of the new compounds were elucidated by NMR and MS analysis and comparison of spectral data with those of previously known compounds. Compounds 4 and 5 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1, 2, 3, and 8 showed weak cytotoxicity.
Zhou
Honglei
H
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Hamazaki
Atsuko
A
Fontana
Jose Domingos
JD
Takahashi
Hironobu
H
Esumi
Tomoyuki
T
Wandscheer
Carolina Bueno
CB
Tsujimoto
Hiroaki
H
Fukuyama
Yoshiyasu
Y
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D006801:Humans; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031586:Melia azedarach / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins