Semisynthesis of linarin, acacetin, and 6-iodoapigenin derivatives from diosmin.
Semisynthesis of linarin and acacetin from the Citrus flavonoid diosmin was performed via, as first intermediate, the 3'-O-phenyltetrazolyl ether of diosmin. This paper relates also a semisynthetic access to 6-iodoapigenin derivatives, which are key compounds in the synthesis of some biflavonoids such as robustaflavone.
Quintin
Jérôme
J
Laboratoire de Pharmacognosie, Centre d'Etudes Pharmaceutiques, 5 Rue J.-B. Clément, 92296 Châtenay-Malabry Cedex, France.
Lewin
Guy
G
D044946:Biflavonoids / Q000138:chemical synthesis / Q000737:chemistry; D002957:Citrus / Q000737:chemistry*; D004145:Diosmin / Q000138:chemical synthesis* / Q000737:chemistry; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
C493146:6-iodoapigenin; D044946:Biflavonoids; D047309:Flavones; D005419:Flavonoids; D006027:Glycosides; C116328:robustaflavone; D004145:Diosmin; C008282:linarin; C023717:acacetin