title: Serum lipid levels correlate with solid tumor weight in hepatoma-bearing rats fed dietary fish oil.
abstract: The effects of dietary fish oil (FO) on serum lipid levels and tumor proliferation were studied in Donryu rats subcutaneously implanted with the ascites hepatoma cell line AH109A. Solid tumor weight was significantly less and serum total cholesterol (T-Ch) level significantly lower in the groups fed the FO diet both before and after AH109A implantation than in the groups fed the corn oil diet. There were no significant effects in the serum lipid levels and tumor proliferation in the groups fed the FO diet only before or after the hepatoma implantation. The serum triacylglyceride, phospholipid, nonesterified fatty acid, T-Ch, and very-low-density lipoprotein+low-density lipoprotein-Ch levels showed significant positive correlations with the solid tumor weight. These results suggest that dietary FO ingestion after hepatoma implantation suppresses tumor proliferation and reduces serum lipid levels along with suppressing tumor proliferation.
authors.affiliation: Department of Applied Biological Science, Tokyo Noko University, Fuchu, Tokyo 183-8509, Japan. masashi@iwate-pu.ac.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawasaki
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yagasaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Miura
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Funabiki
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005395:Fish Oils / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood*; D008114:Liver Neoplasms, Experimental / Q000097:blood* / Q000473:pathology*; D008297:Male; D009368:Neoplasm Transplantation; D010743:Phospholipids / Q000097:blood; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014407:Tumor Cells, Cultured
chemical_list: D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004042:Dietary Fats, Unsaturated; D005230:Fatty Acids, Nonesterified; D005395:Fish Oils; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol