cAMP, tubulin, axonal transport, and regeneration.
Mounting a regenerative response after injury is a multistep process for PNS neurons. The reason for failure of mammalian CNS neurons to regenerate successfully may involve more than one of those steps. Han et al. [Exp. Neurol. 189 (2004) 293] and others show that increasing cAMP levels in neuronal cell bodies elicits a partial regenerative response, altering expression of tubulin isotypes but not expression of other growth-associated genes or rate of axonal transport. This approach allows identification of specific steps in the regenerative response and the roles played by these steps.
Liu
Howard H
HH
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Brady
Scott T
ST
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002490:Central Nervous System / Q000293:injuries / Q000378:metabolism* / Q000503:physiopathology; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology
D014404:Tubulin; D000242:Cyclic AMP