Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting "sleep attacks".
Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of "sleep attacks" in PD was observed.
Rissling
Ida
I
Department of Neurology, Philipps-University Marburg, Germany.
Geller
Frank
F
Bandmann
Oliver
O
Stiasny-Kolster
Karim
K
Körner
Yvonne
Y
Meindorfner
Charlotte
C
Krüger
Hans-Peter
HP
Oertel
Wolfgang H
WH
Möller
J Carsten
JC
D000368:Aged; D000483:Alleles; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced / Q000235:genetics*; D018491:Dopamine Agonists / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000139:chemically induced / Q000235:genetics*; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics; D010865:Pilot Projects; D011110:Polymorphism, Genetic / Q000187:drug effects / Q000235:genetics*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000235:genetics; D050637:Receptors, Dopamine D3; D050638:Receptors, Dopamine D4; D012307:Risk Factors
D000978:Antiparkinson Agents; C493593:DRD3 protein, human; C493599:DRD4 protein, human; D018491:Dopamine Agonists; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D050638:Receptors, Dopamine D4