title: Diffusion/perfusion-weighted magnetic resonance imaging after carotid angioplasty and stenting.
abstract: OBJECTIVE
  Carotid angioplasty and stenting, a so far non-validated procedure, may be an alternative to surgery in patients with a high surgical risk. However, it carries also a risk of cerebral embolic events. The purpose of this study was to evaluate tissue signal abnormalities in the brain before and after carotid angioplasty and stenting by means of diffusion- (DWI) and perfusion (PWI) weighted magnetic resonance imaging (MRI).
  
  
  METHODS
  We performed cerebral MRI before and after carotid angioplasty in 22 consecutive patients, with 23 treated high-grade carotid stenoses. The lesions were located at the origin of the internal carotid artery (ICA) in 20 patients, and at the origin of the common carotid artery (CCA) in 2. MRI was performed the day before, and repeated within 24 hours after the procedure, and examined by two neuroradiologists.
  
  
  RESULTS
  All stent implantations were successful but 4 patients developed an acute neurological deficit within 24 hours after carotid angioplasty. On PWI, Time To Peak (TTP) values ipsilateral to the carotid stenosis were increased before the procedure in 15 patients, and had remained normal in 6 and were not assessable in 1. After the procedure, TTP values were normal in 12 patients, increased in 8 and not assessable in 2. On DWI, new ipsilateral lesions were detected in 2 patients: 1 with an acute neurological deficit and 1 symptom free.
  
  
  CONCLUSIONS
  Perfusion deficits may be present in severe carotid stenosis and be improved within 24 hours by carotid angioplasty and stenting. Asymptomatic infarcts may occur.
authors.affiliation: Service de Neuroradiologie and EA 2691, Hôpital Roger Salengro, Rue Emile Laine, 59037, Lille, France. jygauvrit@chru-lille.fr
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Gauvrit
authors.forename: Christine
authors.initials: C
authors.lastname: Delmaire
authors.forename: Hilde
authors.initials: H
authors.lastname: Henon
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Debette
authors.forename: Mohamad
authors.initials: M
authors.lastname: al Koussa
authors.forename: Didier
authors.initials: D
authors.lastname: Leys
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pruvo
authors.forename: Xavier
authors.initials: X
authors.lastname: Leclerc
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty / Q000706:statistics & numerical data; D016893:Carotid Stenosis / Q000473:pathology* / Q000601:surgery*; D016009:Chi-Square Distribution; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D015607:Stents / Q000706:statistics & numerical data