title: Regional changes of brain serotonin and its metabolite 5-hydroxyindolacetic Acid and development of immunosuppression in submissive mice.
abstract: The production of submissive behavior in C57BL/6J mice during 10 or 20 days of social confrontations resulted in increases in serotonin (5-HT) content in the amygdala, hippocampus, nucleus caudatus, Al1, A10, A9, and hypothalamus. The level of 5-hydroxyindolacetic acid (5-HIAA) was higher in most structures after 20 daily encounters compared to animals tested for 10 days. The ratio 5-HIAA/5-HT was increased in the nucleus raphe, accumbens, A9, and hypothalamus in mice displaying submission during 10 and 20 confrontations. The experience of defeats during 10 days accompanied with 5-HT system activation in a number of brain structures (nucleus raphe, accumbens, and A9) produced immunosuppression. With increasing number of confrontations the ratio 5-HIAA/5-HT was decreased in the same structures and a tendency to the immune response elevation appeared.
authors.affiliation: State Research Institute of Physiology, Russian Academy of Medical Sciences, Siberian Branch, Russian Federation. L.V.Devojno@iphma.nsc.ru
authors.forename: Lidia
authors.initials: L
authors.lastname: Devoino
authors.forename: Elizavrta
authors.initials: E
authors.lastname: Alperina
authors.forename: Elena
authors.initials: E
authors.lastname: Podgornaya
authors.forename: Rostislav
authors.initials: R
authors.lastname: Ilyutchenok
authors.forename: Galina
authors.initials: G
authors.lastname: Idova
authors.forename: Oleg
authors.initials: O
authors.lastname: Polyakov
mesh_terms: D000679:Amygdala / Q000276:immunology / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000276:immunology / Q000378:metabolism*; D002421:Caudate Nucleus / Q000276:immunology / Q000378:metabolism; D004291:Dominance-Subordination; D006624:Hippocampus / Q000276:immunology / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D007031:Hypothalamus / Q000276:immunology / Q000378:metabolism; D007108:Immune Tolerance / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid