Interaction and relationship between angiotensin converting enzyme gene and environmental factors predisposing to essential hypertension in Mongolian population of China.
OBJECTIVE
To investigate the association of specific functional gene ACE (I/D) variants of the renin-angiotensin system with essential hypertension (EH) and interaction between ACE (I/D) gene and risk factors for EH in a genetically homogenous Mongolia rural population of China.


METHODS
Individuals (n=1099) were recruited from general population of Kezuohouqi Banner in Inner Mongolian Autonomous Region.


RESULTS
The association was found between ACE genotype DD plus ID and EH, with an interaction between ACE genotype DD plus ID and cigarette smoking in an additive model. Cigarette smoking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 7.10 to 1.16. Interaction between ACE genotype DD plus ID and alcohol drinking on EH appeared an additive model. Alcohol drinking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 1.66 to 1.09. BMI and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 6.15 to 2.49. Interactions between ACE genotype and WHR on EH showed a multiplicative model. In a short,there was an interaction between ACE gene and cigarette smoking, alcohol drinking and BMI on EH, especially in a low dose-exposure effect


CONCLUSIONS
It is important for individuals who carry ACE D allele gene to prevent EH, and furthermore, to prevent and control coronary heart disease, in a view of population-based prevention.
Xu
Qun
Q
National Laboratory of Medical Molecular Biology, School of Basic Medicine, Peking College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China.
Wang
Yan-Hua
YH
Tong
Wei-Jun
WJ
Gu
Ming-Liang
ML
Wu
Gang
G
Buren
Batu
B
Liu
Yong-Yue
YY
Wang
Jian
J
Li
Yong-Shan
YS
Feng
Hua
H
Bai
Shuang-Lian
SL
Pang
Hai-Hua
HH
Huang
Gui-Rong
GR
Fang
Ming-Wu
MW
Zhang
Yong-Hong
YH
Wu
Zheng-Lai
ZL
Qiu
Chang-Chun
CC
D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking; D000886:Anthropometry; D001786:Blood Glucose; D002681:China; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008986:Mongolia / Q000208:ethnology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics; D012307:Risk Factors; D012424:Rural Population; D012737:Sex Factors; D012907:Smoking; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol; D007703:Peptidyl-Dipeptidase A