title: Influence of orthostatic hypotension in Parkinson's disease on plasma atrial natriuretic peptide.
abstract: The effect of orthostatic hypotension in Parkinson's disease (PD) on plasma atrial natriuretic peptide (ANP) was examined in fifteen individuals with PD without autonomic dysfunction (63-85 years), nine PD patients with autonomic dysfunction (orthostatic hypotension; systolic BP change > 20 mmHg after 5 min standing: 69-82 years) and 14 fit elderly volunteers (62-93 years). The mean ANP level was 42.2 pg/ml (range 16.8-89.2 pg/ml) in the PD group without autonomic dysfunction; 44.4 pg/ml (range 27.2-91.2 pg/ml) in the PD group with autonomic dysfunction; and 48.5 pg/ml (range 22.2-111.6 pg/ml) in the elderly group. There was no statistical difference in plasma atrial natriuretic peptide between all three groups. The mean change in blood pressure was -39 mmHg (systolic) and -18 mmHg (diastolic) between supine and standing in the group with orthostatic hypotension.
authors.affiliation: Department of Geriatrics, Glan Hafren NHS Trust, Newport, Gwent, UK.
authors.forename: S D
authors.initials: SD
authors.lastname: Lennox
authors.forename: D
authors.initials: D
authors.lastname: Sykesa
authors.forename: M
authors.initials: M
authors.lastname: Penney
authors.forename: D
authors.initials: D
authors.lastname: Hampton
authors.forename: K
authors.initials: K
authors.lastname: Woodhouse