title: The extracellular adherence protein from Staphylococcus aureus inhibits neutrophil binding to endothelial cells.
abstract: Extracellular adherence protein (Eap) from Staphylococcus aureus inhibits the adherence of neutrophils to nonstimulated and tumor necrosis factor alpha-stimulated endothelial cells in both static adhesion assays and flow adhesion assays. Consequently, Eap also impaired their transendothelial migration. During an S. aureus infection, Eap may thus serve to reduce inflammation by inhibiting neutrophil adhesion and extravasation.
authors.affiliation: Division of Clinical Bacteriology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Axana
authors.initials: A
authors.lastname: Haggar
authors.forename: Cecilia
authors.initials: C
authors.lastname: Ehrnfelt
authors.forename: Jan
authors.initials: J
authors.lastname: Holgersson
authors.forename: Jan-Ingmar
authors.initials: JI
authors.lastname: Flock
mesh_terms: D001426:Bacterial Proteins / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology* / Q000187:drug effects*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology / Q000378:metabolism; D009504:Neutrophils / Q000166:cytology* / Q000187:drug effects* / Q000382:microbiology; D016601:RNA-Binding Proteins / Q000494:pharmacology*; D013211:Staphylococcus aureus; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; C444739:Eap-N protein, Staphylococcus aureus; D016601:RNA-Binding Proteins; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1