title: Significant ABO hemolytic disease of the newborn in a group B infant with a group A2 mother.
abstract: ABO hemolytic disease of the newborn (HDN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case in which clinically significant ABO-HDN occurred in a group B neonate from anti-B of a group A2 mother. The IgG anti-B titer was much higher (256) than that found in a group A1 mother/infant control group (</= 32). The maternal antibody screen was negative and antibodies to low-frequency antigens were not detected. Therefore, when evaluating unexplained HDN in a group B newborn of a group A mother, it may be relevant to determine the subgroup of the mother. As presented here, anti-B from a group A2 mother may, on occasion, be responsible for HDN.
authors.affiliation: University of Chicago Hospitals, Department of Pathology, Blood Bank, IL 60637, USA.
authors.forename: H
authors.initials: H
authors.lastname: Jeon
authors.forename: B
authors.initials: B
authors.lastname: Calhoun
authors.forename: M
authors.initials: M
authors.lastname: Pothiawala
authors.forename: M
authors.initials: M
authors.lastname: Herschel
authors.forename: B W
authors.initials: BW
authors.lastname: Baron