Dynamics of the cell and its extracellular matrix--a simple mathematical approach.
The extracellular matrix (ECM) is produced by the cells and secreted into the surrounding medium, and consists of a complex mixture of structural and functional proteins. It has been recently observed that the ECM can influence the behavior of cell growth in vitro quite remarkably. A simple mathematical model has been constructed based on negative feedback control mechanisms to represent the dynamics of ECM deposition and cellular differentiation. The model analysis shows a strong relationship between the numerical solution and the experimental observations in cell-polymer constructs for the design of engineered cartilage. The current paper may be a useful guide for those who want to explore the studies on cell-matrix interactions.
Saha
A K
AK
IRIS, Swinburne University of Technology, PO Box 218, Hawthorn, Melbourne, Vic. 3122, Australia.
Mazumdar
J N
JN
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology* / Q000502:physiology*; D003094:Collagen / Q000378:metabolism; D003198:Computer Simulation; D005109:Extracellular Matrix / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D023822:Tissue Engineering / Q000379:methods*
D016326:Extracellular Matrix Proteins; D003094:Collagen