Using a system-on-a-chip implantable device to filter circulating infected cells in blood or lymph.
This paper describes a system on a chip (SoC) that makes use of nanoscale cellular adhesion mechanisms in an integrated electronic microsystem to filter infected cells from blood or lymph. An example of a human immunodeficiency virus-specific SoC is explored in depth. Such systems work in vivo, and blood and lymph are filtered on a continuous basis. With the intelligence on the chip, captured cells can be identified and lyzed, expelled, or otherwise acted upon. These types of systems transfer the burden of research from traditional chemotherapy to bioengineering and system design.
Hanna
Darrin M
DM
School of Engineering and Computer Science, Oakland University, Rochester, MI 48309 USA.
Oakley
Barbara A
BA
Stryker
Gabrielle A
GA
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D001773:Blood Cells / Q000473:pathology*; D001781:Blood Component Removal / Q000295:instrumentation* / Q000379:methods; D002448:Cell Adhesion; D002469:Cell Separation / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004867:Equipment Design; D006801:Humans; D007239:Infections / Q000473:pathology / Q000628:therapy; D008196:Lymph / Q000166:cytology*; D017551:Microdialysis / Q000295:instrumentation / Q000379:methods; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D019736:Prostheses and Implants; D018511:Systems Integration; D014462:Ultrafiltration / Q000295:instrumentation* / Q000379:methods
D020099:Coated Materials, Biocompatible