title: Frequent human leukocyte antigen class I alleles are associated with higher viral load among HIV type 1 seroconverters in Thailand.
abstract: The loss of viral control by the host may be due to the evolution of viruses with mutations that limit presentation by human leukocyte antigen (HLA) to cytotoxic T cells. The authors hypothesized that the consequence of such evolution might be that persons with common HLA class I alleles would be less able to control viremia, on average, than would those with rare alleles. HLA class I typing was completed for 128 injection drug users who seroconverted in a prospective cohort study in Bangkok, Thailand. Logistic regression was used to model viral load (greater than or equal to the median) at 9 and 12 months after seroconversion with an HLA score that profiled the relative prevalence of each individual's alleles. At 12 months after seroconversion, injection drug users with the most common HLA alleles (highest quartile HLA score) had an almost 4-fold increased risk for higher viral load (> or = 32,055 copies/mL) than injection drug users with less common HLA alleles (adjusted odds ratio, 3.92; 95% confidence interval, 1.3-11.8). These findings support the importance of frequency-dependent effects of host genes on HIV type 1 evolution in different populations and suggest that HLA-driven viral evolution critically influences control of viremia in early HIV type 1 infection.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors.forename: Lily
authors.initials: L
authors.lastname: Nguyen
authors.forename: Thanyanan
authors.initials: T
authors.lastname: Chaowanachan
authors.forename: Suphak
authors.initials: S
authors.lastname: Vanichseni
authors.forename: Janet M
authors.initials: JM
authors.lastname: McNicholl
authors.forename: Philip A
authors.initials: PA
authors.lastname: Mock
authors.forename: Robert
authors.initials: R
authors.lastname: Nelson
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Hodge
authors.forename: Frits
authors.initials: F
authors.lastname: van Griensven
authors.forename: Kachit
authors.initials: K
authors.lastname: Choopanya
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Mastro
authors.forename: Jordan W
authors.initials: JW
authors.lastname: Tappero
authors.forename: Dale J
authors.initials: DJ
authors.lastname: Hu
mesh_terms: D000483:Alleles; D005805:Genes, MHC Class I / Q000235:genetics*; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000235:genetics* / Q000821:virology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D015235:HLA-B Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015819:Substance Abuse, Intravenous / Q000150:complications*; D013785:Thailand; D019562:Viral Load
chemical_list: D015483:HIV Antibodies; D015235:HLA-B Antigens