title: Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice.
abstract: We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Chikara
authors.initials: C
authors.lastname: Nakasone
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawakami
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Hoshino
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawase
authors.forename: Koichi
authors.initials: K
authors.lastname: Yokota
authors.forename: Kohichiro
authors.initials: K
authors.lastname: Yoshino
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takeda
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
mesh_terms: D000818:Animals; D054426:Chemokine CXCL2; D017353:Gene Deletion; D020382:Interleukin-18 / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D015846:Monokines / Q000096:biosynthesis / Q000276:immunology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D011552:Pseudomonas Infections / Q000276:immunology* / Q000378:metabolism / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000276:immunology
chemical_list: D054426:Chemokine CXCL2; D020382:Interleukin-18; D015846:Monokines; D014409:Tumor Necrosis Factor-alpha