Stable isotopes in obesity research.
Obesity is recognized as a major public health problem. Obesity is a multifactorial disease and is often associated with a wide range of comorbidities including hypertension, non-insulin dependent (Type II) diabetes mellitus, and cardiovascular disease, all of which contribute to morbidity and mortality. This review deals with stable isotope mass spectrometric methods and the application of stable isotopes to metabolic studies of obesity. Body composition and total energy expenditure (TEE) can be measured by mass spectrometry using stable isotope labeled water, and the metabolism of protein, lipid, and carbohydrate can be measured using appropriate labeled tracer molecules.
Dolnikowski
Gregory G
GG
Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA. gregory.dolnikowski@tufts.edu
Marsh
Julian B
JB
Das
Sai Krupa
SK
Welty
Francine K
FK
D004734:Energy Metabolism; D006801:Humans; D007554:Isotopes; D013058:Mass Spectrometry; D009765:Obesity / Q000175:diagnosis* / Q000378:metabolism*
D007554:Isotopes