title: Quantitative analysis of endosonographic parenchymal echogenicity in patients with chronic pancreatitis.
abstract: OBJECTIVE
  The aim of the study was to develop a method of quantitation of endoscopic ultrasonography (EUS) changes of chronic pancreatitis (CP).
  
  
  METHODS
  Twenty-three patients with chronic pancreatitis by EUS were compared with nine normal subjects. Hyperechogenicity was evaluated as the size of the hyperechoic area that was over a threshold echogenicity level. Mean echo density was expressed using the average gray-scale value within the region of interest. The quantitative data were compared with the diagnosis using conventional EUS criteria.
  
  
  RESULTS
  The size of the hyperechoic area over the threshold level was 0.86 +/- 0.67 mm2 (mean +/- SD) in the normal pancreas using EUS criteria. In chronic pancreatitis, the size of the hyperechoic area was 7.28 +/- 2.98 mm2 in patients with mild CP, 18.12 +/- 2.56 mm2 in patients with moderate CP, and 18.02 +/- 10.81 mm2 in patients with severe CP, respectively. These changes in hyperechoic size area were statistically significant in all patients having mild to severe CP when compared with normal controls.
  
  
  CONCLUSIONS
  Computer analysis of EUS images may provide objective information for the diagnosis of CP and may be useful in quantitating the severity of disease and overcoming interobserver variability in analyzing individual echo features supporting the diagnosis of CP.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Center for Endoscopic Ultrasound and Center for Experimental Endoscopy, University of Florida, Florida, USA.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Girish
authors.initials: G
authors.lastname: Mishra
authors.forename: Lyndon V
authors.initials: LV
authors.lastname: Hernandez
authors.forename: Manoop S
authors.initials: MS
authors.lastname: Bhutani
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003936:Diagnosis, Computer-Assisted; D019160:Endosonography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000000981:diagnostic imaging*