title: Development of an implantable undulation type ventricular assist device for control of organ circulation.
abstract: It is well known that a rotary blood pump (RP) is effective as a small ventricular assist device (VAD). It might be still more effective if pulsation was available. The undulation pump (UP), which is a type of small RP, can also produce pulsation. In Japan, a development project for an implantable type UP ventricular assist device (UPVAD) is now advanced. Six universities and some companies together have been in charge of the development project for 5 years. In this study, the influence which the UP under development has on circulation in internal organs was investigated. Goats with the same weight as an average Asian person were used for the experiment. The left chest cavity was opened after resection of the fourth rib and the heart was approached. A cannula was inserted in the left ventricle from the apex. An outflow cannula was inserted into the left descending aorta. Heart muscle was excised using a newly developed puncher. The UPVAD was implanted using a left-heart bypass system. The myocardial blood flow, carotid arterial blood flow, and the kidney blood flow were recorded together with an electrocardiogram, blood pressure, and the flow rate. In these animal experiments, the blood circulation dynamic state was stabilized and sufficient support of the left heart was observed. Myocardial blood flow, carotid arterial flow, and a kidney blood flow increase resulting from UPVAD support was observed. Often the problem of multiple organ failure is important at the time of clinical application of a ventricular assist device. Assisting circulation to internal organs is important for prevention of multiple organ failure. It was concluded that the UPVAD might be useful for prevention of multiple organ failure.
authors.affiliation: Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Tohoku, Japan. yambe@idac.tohoku.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yambe
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Abe
authors.forename: Kou
authors.initials: K
authors.lastname: Imachi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shiraishi
authors.forename: Mune-Ichi
authors.initials: M
authors.lastname: Shibata
authors.forename: Tasuku
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Quintian
authors.initials: Q
authors.lastname: Wang
authors.forename: Xudong
authors.initials: X
authors.lastname: Duan
authors.forename: Hongjian
authors.initials: H
authors.lastname: Liu
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshizawa
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Matsuki
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Sato
authors.forename: You-Ichi
authors.initials: Y
authors.lastname: Haga
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Esashi
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tabayashi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasada
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Umezu
authors.forename: Takehisa
authors.initials: T
authors.lastname: Matsuda
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Nitta
mesh_terms: D000818:Animals; D001243:Assisted Circulation / Q000295:instrumentation*; D001698:Biomedical Engineering; D001783:Blood Flow Velocity; D049628:Body Size; D004867:Equipment Design; D006353:Heart-Assist Devices; D007564:Japan; D023421:Models, Animal