title: A neuroendocrine-based regulatory fatigue model.
abstract: OBJECTIVE
  To provide an overview of select existing fatigue models and propose a neuroendocrine-based regulatory fatigue model that can serve as a foundation for interventions to manage fatigue.
  
  
  METHODS
  Biobehavioral systems based on a neuroendocrine regulatory framework.
  
  
  METHODS
  Empirical data and literature review to develop a fatigue model to serve as a foundation for interventions to manage fatigue.
  
  
  CONCLUSIONS
  The proposed model will facilitate testing of interventions based on the premise that common neuroendocrine transmitters provide the mechanisms of fatigue in patients diagnosed with chronic illnesses, such as with cancer treatment-related fatigue. The model may also be used to identify predictors of fatigue in specific patient populations, provide guidance for clinicians in their selection of precise interventions to be implemented, and identify the effects of treatments captured in these populations. By clearly identifying the mechanisms of fatigue, we can discover which interventions are effective for particular types of fatigue.
authors.affiliation: Duke University School of Nursing, Durham, NC 27710, USA. Payne031@mc.duke.edu.
authors.forename: Judith K
authors.initials: JK
authors.lastname: Payne
mesh_terms: D002940:Circadian Rhythm; D005221:Fatigue / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D007030:Hypothalamo-Hypophyseal System; D008954:Models, Biological; D009490:Neurosecretory Systems; D018377:Neurotransmitter Agents; D010913:Pituitary-Adrenal System
chemical_list: D018377:Neurotransmitter Agents