title: Complex variant Philadelphia translocation involving the short arm of chromosome 9 in a case of chronic myeloid leukemia.
abstract: Here we describe how we detected the BCR/ABL fusion gene on the short arm of der(9) combining classical GTG banding and Fluorescence In Situ Hybridization (FISH) in a case of chronic myeloid leukemia (CML). To our knowledge, variant translocations involving the short arm of chromosome 9, in literature, are almost rare in chronic myeloid leukemia. It is not clear if this complex genetic translocation represents clonal evolution or a unique, initial presentation variant of the Philadelphia chromosome (Ph).
authors.affiliation: Department of Clinical Pathology, Cytogenetic Unit, Regina Elena Cancer Institute, Rome, Italy. cianciulli@ifo.it <cianciulli@ifo.it>
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Cianciulli
authors.forename: Raffaella
authors.initials: R
authors.lastname: Marzano
authors.forename: Roberta
authors.initials: R
authors.lastname: Merola
authors.forename: Giulia
authors.initials: G
authors.lastname: Orlandi
authors.forename: M Concetta
authors.initials: MC
authors.lastname: Petti
authors.forename: Fiorella
authors.initials: F
authors.lastname: Guadagni
authors.forename: Francesco
authors.initials: F
authors.lastname: Pisani
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D015466:Leukemia, Myeloid, Chronic-Phase / Q000235:genetics*; D010677:Philadelphia Chromosome