title: The Py235 proteins: glimpses into the versatility of a malaria multigene family.
abstract: Py235 rhoptry proteins, encoded by a multigene family of the rodent malaria parasite Plasmodium yoelii, combine a functional role in invasion with one of immune evasion, and have homologues in malaria parasites of humans. Investigations of Py235 are summarised and the perspectives for dissecting the molecular and biological mechanisms underlying these crucial phenomena are discussed.
authors.affiliation: Département d'Immunologie, Institut Cochin, Inserm U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France.
authors.forename: Anne Charlotte
authors.initials: AC
authors.lastname: Grüner
authors.forename: Georges
authors.initials: G
authors.lastname: Snounou
authors.forename: Katy
authors.initials: K
authors.lastname: Fuller
authors.forename: William
authors.initials: W
authors.lastname: Jarra
authors.forename: Laurent
authors.initials: L
authors.lastname: Rénia
authors.forename: Peter R
authors.initials: PR
authors.lastname: Preiser
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008288:Malaria / Q000469:parasitology; D005810:Multigene Family; D010967:Plasmodium yoelii / Q000472:pathogenicity*; D015800:Protozoan Proteins / Q000235:genetics*
chemical_list: D015800:Protozoan Proteins; C065352:rhoptry associated protein, Plasmodium