title: Non-ablative skin remodeling: an 8-month clinical and 3D in vivo profilometric study with an 810 nm diode laser.
abstract: BACKGROUND
  Non-ablative remodeling has recently been proposed as a new anti-aging treatment with no downtime.
  
  
  OBJECTIVE
  This study aimed to evaluate objectively, with a three-dimensional (3D) in vivo profilometric study, the efficacy and safety of non-ablative skin remodeling with an 810 nm diode laser on periorbital wrinkles with an 8-month follow-up.
  
  
  METHODS
  Ten female patients (mean age: 55 years) were treated three times at 1-month intervals and then evaluated 5 months after the last treatment. Patients were evaluated using clinical data, standardized photographs and 3D in vivo profilometry in order to quantify the degree of improvement. This objective method evaluates the general degree of roughness (anisotropy) and the depth of the wrinkles.
  
  
  RESULTS
  An observer independent from the study showed slight improvement in the quality of the skin and visual aspect of the wrinkles at 3 months. Eight months later this was confirmed to a lesser degree by clinical and 3D profilometry. No immediate or late adverse effects were noted at any stage of the procedure.
  
  
  CONCLUSIONS
  This study demonstrated that irradiation with a 810 nm laser emitting in a pulsed mode and connected to a cooling system reduced anisotropy of the skin and improved the clinical aspects of the wrinkles. Results appear quickly at 3 months and are stable at 8 months.
authors.affiliation: Centre Laser Dermatologique, Marseille, France. laserder@jeanluclevy.com
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Levy
authors.forename: Mario
authors.initials: M
authors.lastname: Trelles
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Servant
authors.forename: Lise
authors.initials: L
authors.lastname: Agopian
mesh_terms: D000328:Adult; D005260:Female; D050904:Homocysteine S-Methyltransferase; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D053685:Laser Therapy; D007834:Lasers / Q000145:classification*; D008780:Methyltransferases; D008875:Middle Aged; D015595:Skin Aging / Q000502:physiology*
chemical_list: D008780:Methyltransferases; D050904:Homocysteine S-Methyltransferase