title: The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia.
abstract: In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of > or =1,000 parasites/microl than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.
authors.affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom. patrick.corran@lshtm.ac.uk
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Corran
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: O'Donnell
authors.forename: Jim
authors.initials: J
authors.lastname: Todd
authors.forename: Chairat
authors.initials: C
authors.lastname: Uthaipibull
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Holder
authors.forename: Brendan S
authors.initials: BS
authors.lastname: Crabb
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Riley
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005714:Gambia / Q000453:epidemiology / Q000208:ethnology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D020066:Merozoite Surface Protein 1 / Q000737:chemistry* / Q000276:immunology*; D008970:Molecular Weight; D018512:Parasitemia / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000737:chemistry / Q000276:immunology*; D015995:Prevalence
chemical_list: D000913:Antibodies, Protozoan; D020066:Merozoite Surface Protein 1