[Indinavir and renal lithiasis].
Indinavir is a new specific and potent drug that inhibits, like other antiretroviral agents, the protease of immune deficiency virus (HIV) or acquired immune deficiency syndrome (AIDS), an enzyme necessary to maduration and replication of the virus. Indinavir has the capacity to bind the active site causing a decrease in plasma of HIV1-RNA and an increase of T-CD4 helper lymphocytes. The aim of this work is to study in HIV and/or AIDS patients treated with indinavir the crystalluria and the formation of renal calculi due to the clearance of this drug. Two out of nine patients studied in this work presented abundant crystalluria and one of them presented spontaneously passed renal stone. Urinary crystals were studied under polarized-light microscopy and renal stone was analyzed by infrared spectroscopy.
Traba Villameytide
Ma L
ML
Laboratorio de Bioquímica, Sección de Fisiopatología Osea, Medicina Interna, Fundación Jiménez Díaz, Madrid.
Fernández-Guerrero
M
M
D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D015497:HIV-1; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D013055:Spectrophotometry, Infrared; D014545:Urinary Calculi / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
D017320:HIV Protease Inhibitors; D019469:Indinavir
Litiasis renal inducida por indinavir.