title: Aerosol delivery during mechanical ventilation to the rat.
abstract: The authors have adjusted a jet nebulizer to a mechanical ventilator (Servo Ventilator, Siemens) to deliver an aerosol to rats. They aimed to clarify whether a modified jet nebulizer generating particles with a mass median aerodynamic diameter of 2 microm would be effective and safe in intubated ventilated rats. Fluorescent microspheres (diameter: 1.0 microm) were aerosolized to verify qualitatively and quantitatively intrapulmonary deposition. Particle deposition fraction was 3.8% (1.3%) of the delivered dose (median [interquartile range]). There was no evidence for any adverse event as assessed from heart rate, mean arterial pressure, PaO2 and PaCO2 before, during, and after nebulization. No pulmonary tissue trauma was detected histologically.
authors.affiliation: Department of Anaesthesiology, University of Frankfurt, Frankfurt, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hofstetter
authors.forename: Michael
authors.initials: M
authors.lastname: Flondor
authors.forename: Michael
authors.initials: M
authors.lastname: Flonder
authors.forename: Sandra
authors.initials: S
authors.lastname: Hoegl
authors.forename: Sandra
authors.initials: S
authors.lastname: Hoeg
authors.forename: Eckart
authors.initials: E
authors.lastname: Thein
authors.forename: Gregor
authors.initials: G
authors.lastname: Kemming
authors.forename: Hille
authors.initials: H
authors.lastname: Kisch-Wedel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kreyling
authors.forename: Bernhard
authors.initials: B
authors.lastname: Zwissler
mesh_terms: D000336:Aerosols; D000818:Animals; D001794:Blood Pressure; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D006339:Heart Rate; D008170:Lung Compliance; D008297:Male; D008863:Microspheres; D009330:Nebulizers and Vaporizers; D011650:Pulmonary Alveoli; D051381:Rats; D017207:Rats, Sprague-Dawley; D012121:Respiration, Artificial / Q000295:instrumentation* / Q000379:methods*; D013667:Technetium
chemical_list: D000336:Aerosols; D005456:Fluorescent Dyes; D013667:Technetium