Preparation and in-vivo evaluation of 99mTc-IOTIDA for cholescintigraphy.
The synthesis, radiolabeling and in vivo evaluation of 99mTc-IOIDA(3-iodo 2,4,6-trimethylpheyl carbamoylmethyl iminodiacetic acid) for the assessment of hepatocytic function and the functional status of the cystic duct and the gallbladder are described. For a scintigraphic imaging comparison, three different 99mTc-IDA derivatives, 99mTc-DISIDA, 99mTc-mebrofenin and 99mTc-IOTIDA, were prepared and evaluated for their in vivo pharmacokinetic behavior through animal studies. Serial static image scans of rabbits injected with 99mTc-IOTIDA revealed that none of the tissues except the hepatobiliary system showed radioactivity concentrations. A scintigraphic study in a healthy volunteer showed that most of the administrated radioactivity accumulated in the liver and was rapidly excreted through the hepatobiliary system, visualizing the gallbladder within 15 min. In conclusion, 99mTc-IOTIDA is a potential hepatobiliary imaging agent for the evaluation of the functional status of hepatocytes and the patency of the biliary duct.
Hong
Young-Don
YD
Division of Radioisotope Production and Application, HANARO Center, Korea Atomic Energy Research Institute, Dukjin-dong 150, Yuseong, Daejeon 305-353, South Korea. ydhong@kaeri.re.ki
Jang
Beom-Su
BS
Choi
Sang-Mu
SM
Park
Woong-Woo
WW
Park
Kyung-Bae
KB
Choi
Sun-Ju
SJ
D000818:Animals; D001652:Bile Ducts / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000378:metabolism; D007098:Imino Acids / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D007553:Isotope Labeling / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D014018:Tissue Distribution
D007098:Imino Acids; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C065266:technetium Tc 99m-3-iodo-2,4,6-trimethylphenylcarbamoylmethyliminodiacetic acid