Techniques: species' finest blend--humanized mouse models in inflammatory skin disease research.
Differences between humans and mice often hamper the transfer of promising results from the bench to the clinic. For ethical reasons, research that involves patients is limited, and so there is an urgent need for models that mimic the human situation as closely as possible. In recent years, there has been considerable progress in generating humanized mouse models, and their application to drug discovery has proved fruitful. So, how can mice be humanized, and how can humanized mice be employed in immunology research and drug discovery? In this article, we answer these questions, focusing on T-cell-mediated skin diseases as an example.
Igney
Frederik H
FH
Schering AG, CRBA Dermatology, Berlin, Germany. frederik.igney@schering.de
Asadullah
Khusru
K
Zollner
Thomas M
TM
D000818:Animals; D003872:Dermatitis / Q000188:drug therapy* / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice / Q000276:immunology*; D012107:Research Design; D013045:Species Specificity