title: [Relationship between genetic polymorphism of tumor necrosis factor-alpha and susceptibility to intrauterine HBV infection].
abstract: OBJECTIVE
  To study the possible relationship between tumor necrosis factor (TNF)-alpha-238G/A gene polymorphism and the susceptibility to intrauterine HBV infection.
  
  
  METHODS
  Two hundred and fifty-six children, including 130 infants born to HBsAg positive mothers were divided into two groups: forty-five children with intrauterine HBV infection (group I) and 85 children without intrauterine HBV infection (group II), with a control group of 126. TNF-alpha-238G/A gene polymorphism was examined in all 256 children, by means of real-time quantitative fluorescent PCR.
  
  
  RESULTS
  A significant difference of TNF-alpha-238A allele frequency was found between group I and group II (x2=6.797, P=0.009), and between group I and the controls group (x2=0.047, P=0.002), but there was no significant difference between group II and the control groups (x2=0.047, p=0.828).
  
  
  CONCLUSIONS
  This study found that genetic polymorphism of tumor necrosis factor-a was associated with intrauterine HBV infection
authors.affiliation: Department of Infectious Diseases, Children's Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Shao-Qing
authors.initials: SQ
authors.lastname: Gu
authors.forename: Qi-Rong
authors.initials: QR
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Lin-E
authors.initials: LE
authors.lastname: Fei
authors.forename: Zuo-Quan
authors.initials: ZQ
authors.lastname: Dong
authors.forename: Dong-Po
authors.initials: DP
authors.lastname: Pu
mesh_terms: D000328:Adult; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D006509:Hepatitis B / Q000635:transmission*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors / Q000235:genetics*
chemical_list: C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors