Vitiligo as a paraneoplastic syndrome preceding pituitary adenoma and subsequent acute lymphoblastic leukemia.
We present an unusual case of rapid onset of vitiligo heralding blindness due to pituitary apoplexy secondary to a non-secreting pituitary adenoma in a 49-year-old man. Deterioration in vision and skin condition coincided with tumor progression over 3 years. He subsequently died of acute lymphoblastic leukemia after pituitary radiation. The possible pathological associations between the 2 malignancies and vitiligo are discussed.
Au
Wing Y
WY
Department of Medicine, Queen Mary Hospital, Hong Kong. auwing@hotmail.com
Hon
Charmaine
C
Chan
Alex C L
AC
Sano
Toshiaki
T
Chan
Henry H
HH
D000236:Adenoma / Q000150:complications / Q000175:diagnosis*; D001766:Blindness / Q000175:diagnosis / Q000209:etiology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000209:etiology; D014820:Vitiligo / Q000175:diagnosis* / Q000209:etiology