title: [Bax and bcl-2 imbalance and HPB infection in penile tumors and adjacent tissues].
abstract: OBJECTIVE
  To analyze the expression pattern of apoptotic related proteins Bax and Bcl-2 and HPV virus infection in samples of penile carcinomas and adjacent tissues.
  
  
  METHODS
  Bax and Bcl-2 were assayed by Western Blot and HPV virus presence by PCR in 16 tumor samples, 11 adjacent skin and 10 adjacent corpus cavernosum samples. Normal penile tissues were used as controls.
  
  
  RESULTS
  Comparative to control samples, tumors showed an imbalance in Bax and Bcl-2 expression. These alterations were also observed in tumor adjacent tissues. We found that 37.5% (6/16) of our samples were infected by HPV.
  
  
  CONCLUSIONS
  Bax and Bcl-2 imbalance is probably associated with the neoplastic process. No correlation between Bax/Bcl-2 balance and patient age and tumor differentiation was found. HPV infection should not be the major cause for penis cancer development.
authors.affiliation: Département de Génétique, Institut de Biologie, UFRJ, Brésil.
authors.forename: Patricia de Souza
authors.initials: Pde S
authors.lastname: Nascimento
authors.forename: Antonio Augusto
authors.initials: AA
authors.lastname: Ornellas
authors.forename: Mèrcia Mendes
authors.initials: MM
authors.lastname: Campos
authors.forename: Marcos Antonio Mauricio
authors.initials: MA
authors.lastname: Scheiner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Fiedler
authors.forename: Gilda
authors.initials: G
authors.lastname: Alves
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications*; D010412:Penile Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D051028:bcl-2-Associated X Protein
chemical_list: C494826:BAX protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein
vernacular_title: Déséquilibre de Bax, Bcl-2, et infection par HPV dans les tumeurs du pénis et les tissus adjacents.