title: Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples.
abstract: The present study investigated polymorphisms of the NOTCH 4 gene in two independent samples from India and USA, consisting of patients with schizophrenia and their parents (n = 182, and n = 148 'trios,' respectively). Five DNA markers, namely (GAAG)(n), (TAA)(n), SNP1, SNP2, and (CTG)(n) were evaluated. Transmission distortion, consistent with a modest association was detected among both samples. Additional association studies at this locus are warranted.
authors.affiliation: Department of Genetics, University of Delhi, South Campus, Benito Juarez Road, New Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Prasad
authors.forename: K V
authors.initials: KV
authors.lastname: Chowdari
authors.forename: J
authors.initials: J
authors.lastname: Wood
authors.forename: T
authors.initials: T
authors.lastname: Bhatia
authors.forename: S N
authors.initials: SN
authors.lastname: Deshpande
authors.forename: V L
authors.initials: VL
authors.lastname: Nimgaonkar
authors.forename: B K
authors.initials: BK
authors.lastname: Thelma
mesh_terms: D000483:Alleles; D001483:Base Sequence; D005192:Family Health; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007194:India; D015810:Linkage Disequilibrium; D008297:Male; D009679:Nuclear Family; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D000074562:Receptor, Notch4; D011956:Receptors, Cell Surface / Q000235:genetics*; D051880:Receptors, Notch; D012559:Schizophrenia / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000235:genetics; D014481:United States
chemical_list: C106075:NOTCH4 protein, human; D011518:Proto-Oncogene Proteins; D000074562:Receptor, Notch4; D011956:Receptors, Cell Surface; D051880:Receptors, Notch