Mitochondrial trafficking in neurons: a key variable in neurodegeneration?
Mitochondria are the proximate target of a number of different neurotoxins. Typically, impairing of the key bioenergetic function of mitochondria by toxins is considered as the main mechanism of action. However, the effective maintenance of energy generation in neurons depends on the biogenesis, trafficking, and degradation of mitochondria in addition to the traditional bioenergetic functions. We have recently demonstrated that glutamate alters both the trafficking and morphology of mitochondria in primary neurons. In addition, several other potential neurotoxins, including nitric oxide and zinc, inhibit mitochondrial movement and, in some cases, alter morphology too. This suggests that some part of the action of neurotoxins might include the impairment of mitochondrial trafficking in neurons, with the resultant failure of local ATP delivery.
Reynolds
Ian J
IJ
Department of Pharmacology, University of Pittsburgh, W1351 Biomedical Science Tower, Pittsburgh, Pennsylvania 15261, USA. iannmda@pitt.edu
Malaiyandi
Latha M
LM
Coash
Marcy
M
Rintoul
Gordon L
GL
D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D019636:Neurodegenerative Diseases / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D009498:Neurotoxins / Q000633:toxicity*; D021381:Protein Transport / Q000187:drug effects*
D009498:Neurotoxins