Paxillin: adapting to change.
Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in cell migration and gene expression.
Brown
Michael C
MC
Dept. of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
Turner
Christopher E
CE
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D051419:Paxillin; D010750:Phosphoproteins / Q000737:chemistry* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D003598:Cytoskeletal Proteins; D006133:Growth Substances; D016023:Integrins; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins