New aspects on the preparation of [11C]acetate--a simple and fast approach via distillation.
[11C]Acetate, initially developed for nuclear cardiology has gained increased interest also for oncological problems. A conjoint problem of all preparation methods is the high sensitivity of the Grignard-precursor to moisture, demanding long cleaning and drying procedures of apparatus and reaction vials. Our rationale was to simplify and accelerate the preparation of [11C]acetate by the development of an inert, sterile and disposable system. The present publication deals with the remote-controlled preparation of [11C]acetate via distillation into a buffer ready to use.
Mitterhauser
Markus
M
Department of Nuclear Medicine, University of Vienna, AKH Wien, Waehringer Guertel 18-20, Vienna A1090, Austria. markus.mitterhauser@akh-wien.ac.at
Wadsak
Wolfgang
W
Krcal
Andreas
A
Schmaljohann
Joern
J
Bartosch
Ewald
E
Eidherr
Harald
H
Viernstein
Helmut
H
Kletter
Kurt
K
D000085:Acetates / Q000138:chemical synthesis* / Q000302:isolation & purification*; D002244:Carbon / Q000302:isolation & purification*; D005591:Chemical Fractionation / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000302:isolation & purification
D000085:Acetates; D019275:Radiopharmaceuticals; C438206:carbon-11 acetate; D002244:Carbon