title: Sarcoidosis manifesting as massive splenomegaly: a rare occurrence.
abstract: Sarcoidosis is a multisystemic granulomatous disease of unknown origin occurring worldwide and affecting people of all races and ages. This disease manifests most frequently with bilateral hilar lymphadenopathy, pulmonary infiltrates, and skin and ocular lesions. Granulomatous inflammation of the spleen is common in patients with sarcoidosis, but splenic enlargement is unusual and massive splenomegaly quite rare. Splenomegaly is usually homogeneous, but multiple low-attenuating nodular lesions are occasionally seen and easily mistaken for lymphoma, metastases, or infections such as tuberculosis. We describe an unusual case of sarcoidosis in a woman who presented with massive splenomegaly with extensive nodularity that cleared completely with corticosteroid therapy.
authors.affiliation: Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
authors.forename: Anant
authors.initials: A
authors.lastname: Mohan
authors.forename: Rita
authors.initials: R
authors.lastname: Sood
authors.forename: Nasir
authors.initials: N
authors.lastname: Shariff
authors.forename: Manpreet Singh
authors.initials: MS
authors.lastname: Gulati
authors.forename: Siddharth Datta
authors.initials: SD
authors.lastname: Gupta
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Dutta
mesh_terms: D000328:Adult; D001706:Biopsy; D003287:Contrast Media; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D012507:Sarcoidosis / Q000000981:diagnostic imaging / Q000473:pathology*; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media