title: Peritoneal dialysis in end-stage renal disease after liver transplantation.
abstract: Peritoneal dialysis (PD) has seldom been reported in patients developing end-stage renal disease (ESRD) after liver transplantation (LTx). Here we present our recent experience with PD in 5 such patients. Of the 5 patients, 3 were men and 2 were women. Average age at initiation of PD was 64.6 years (range: 54 - 72 years). Chronic renal failure (CRF) was diagnosed an average of 3.8 years (range: 1 - 7 years) post transplant and resulted in ESRD an average of 9.2 years (range: 6 - 15 years) after LTx. Calcineurin inhibitor toxicity was the presumed causative factor in all 5 patients, with biopsy confirmation in 2. All of the patients had hypertension at the time of diagnosis of CRF, 2 had coronary artery disease, and 1 developed diabetes mellitus. No patient had ascites before PD initiation. Peritoneal dialysis catheter implantation was uneventful in all patients. Average duration of follow-up was 13.6 months (range: 6 - 29 months). Three episodes of peritonitis occurred in 2 patients (coagulase-negative staphylococcus, Staphylococcus aureus, and Acinetobacter). All episodes of peritonitis responded to standard treatment. Clearance was found to be adequate in all but 1 patient. One patient died 19 months after initiation of PD. At the time of writing, the remaining 4 patients are alive on PD after an average of 12.2 months (range: 6 - 29 months). We conclude that PD is a viable and safe option for managing ESRD that develops after LTx.
authors.affiliation: Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ashutosh M
authors.initials: AM
authors.lastname: Shukla
authors.forename: Thierry
authors.initials: T
authors.lastname: Lobbedez
authors.forename: Maggie
authors.initials: M
authors.lastname: Chu
authors.forename: Sharone
authors.initials: S
authors.lastname: Izatt
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Bargman
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Oreopoulos
mesh_terms: D000368:Aged; D065095:Calcineurin Inhibitors; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010538:Peritonitis / Q000209:etiology / Q000382:microbiology
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents