title: Adrenal insufficiency due to primary bilateral adrenal non-Hodgkin's lymphoma.
abstract: A case of primary adrenal insufficiency, secondary to primary bilateral adrenal lymphoma is reported. A 50-year-old woman presented with features of primary adrenal insufficiency (darkening of skin, asthenia, anorexia, constipation) for at least 8 months. Clinical examination was unremarkable except for low body mass index and generalized skin and buccal mucosal pigmentation. Routine investigations including complete hemogram, serum chemistry, urine analysis, chest radiograph and electrocardiogram were normal; serum lactate dehydrogenase was moderately elevated. Primary adrenal insufficiency was confirmed on cortisol dynamics (very low basal and peak cortisol) after insulin-induced hypoglycemia. Routinely detected adrenal masses on ultrasonography were confirmed by contrast enhanced CT abdomen. A diagnosis of primary adrenal non- Hodgkin's lymphoma (B-cell) was made after exploratory laprotomy and further staging. The patient was put on combination chemotherapy (CHOP) protocol, but was lost to follow-up after receiving two cycles of treatment. Primary adrenal lymphoma, although a rare entity, needs to be suspected in patients with features of primary adrenal insufficiency who have evidence of bilateral adrenal masses on imaging.
authors.affiliation: Department of Endocrinology, Sher-i-kashmir Institute of Medical Sciences, Srinagar, Kashmir, India. abdulhamidz@vsnl.com
authors.forename: A
authors.initials: A
authors.lastname: Hamid Zargar
authors.forename: B
authors.initials: B
authors.lastname: Ahmad Laway
authors.forename: K
authors.initials: K
authors.lastname: Alam Bhat
authors.forename: A
authors.initials: A
authors.lastname: Shah
authors.forename: M
authors.initials: M
authors.lastname: Ahmad
authors.forename: S
authors.initials: S
authors.lastname: Aejaz Aziz
authors.forename: M
authors.initials: M
authors.lastname: Iftikhar Bashir
authors.forename: A
authors.initials: A
authors.lastname: Iqbal Wani
authors.forename: M
authors.initials: M
authors.lastname: Hayat Bhat
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D000309:Adrenal Insufficiency / Q000188:drug therapy / Q000209:etiology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone