title: A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model.
abstract: We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.
authors.affiliation: Department of Biochemistry, Chonbuk National University Medical School, Chonju, Republic of Korea.
authors.forename: Young-Rae
authors.initials: YR
authors.lastname: Lee
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Park
authors.forename: Zhao-Zhen
authors.initials: ZZ
authors.lastname: Lin
authors.forename: Young-Jong
authors.initials: YJ
authors.lastname: Kho
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Hye-Won
authors.initials: HW
authors.lastname: Rho
authors.forename: Bon-Sun
authors.initials: BS
authors.lastname: Koo
authors.forename: Hyung-Rho
authors.initials: HR
authors.lastname: Kim
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Song
authors.forename: Hong-Nu
authors.initials: HN
authors.lastname: Yu
authors.forename: Myung-Kwan
authors.initials: MK
authors.lastname: Han
authors.forename: Seung-Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Eun-Chung
authors.initials: EC
authors.lastname: Jhee
authors.forename: Jong-Suk
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000418:Albumins / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002147:Calmodulin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects*; D002460:Cell Line; D003603:Cytotoxins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D023421:Models, Animal; D021381:Protein Transport / Q000187:drug effects; D014268:Trifluoperazine / Q000494:pharmacology*; D041261:Vibrio vulnificus / Q000737:chemistry / Q000472:pathogenicity* / Q000502:physiology
chemical_list: D000418:Albumins; D002147:Calmodulin; D003603:Cytotoxins; D014268:Trifluoperazine; D002118:Calcium