title: Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal spray.
abstract: Oxymetazoline is a sympathomimetic amine found in over-the-counter nasal decongestants. We report a case of chronic use of nasal oxymetazoline associated with thunderclap headache due to reversible segmental intracranial vasoconstriction.
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alta.
authors.forename: Andrea H S
authors.initials: AH
authors.lastname: Loewen
authors.forename: Mark E
authors.initials: ME
authors.lastname: Hudon
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hill
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D001921:Brain / Q000098:blood supply*; D004334:Drug Administration Schedule; D005260:Female; D006261:Headache / Q000139:chemically induced* / Q000503:physiopathology*; D006801:Humans; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000009:adverse effects*; D010109:Oxymetazoline / Q000008:administration & dosage / Q000009:adverse effects*; D014661:Vasoconstriction / Q000502:physiology*
chemical_list: D014663:Nasal Decongestants; D010109:Oxymetazoline