Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy.
Cytokines, having central functions in immunological and inflammatory process, are always expected to play important roles in the pathogenesis of various diseases, such as asthma. Genetic polymorphisms of those cytokine and cytokine receptor genes are the focus of genetic association studies. In an effort to identify gene(s) whose variant(s) are involved in the development of asthma, we examined the genetic effects of 19 single nucleotide polymorphisms in eight cytokine and cytokine receptor genes, including IL1A, IL1B, IL2, IL3, IL4, IL8, IL10, and IL5RA, on asthma and atopy. Nineteen single nucleotide polymorphisms in eight cytokine and cytokine receptor genes were genotyped using the single-base extension method in a Korean asthma cohort (n = 723). Logistic regression and multiple regressions were used for statistical analyses controlling for smoking, age, and gender as covariables. Genetic association analysis of polymorphisms revealed that one exonic (exon 1), IL3 + 79T > C ( Ser27Pro), showed significant association with the risk of asthma and atopy. The Pro allele had shown dominant and protective effects on development of asthma in nonatopic subjects (P = 0.002) and also showed significant association with the risk of atopy in normal control subjects (P = 0.007). This information about the genetic association of important genes with asthma might provide valuable insights into strategies for the pathogenesis of asthma and atopy.
Park
Byung Lae
BL
Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-gu, Seoul, 110-834, South Korea.
Kim
Lyoung Hyo
LH
Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-gu, Seoul, 110-834, South Korea.
Choi
Yoo Hyun
YH
Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-gu, Seoul, 110-834, South Korea.
Lee
June-Hyuk
JH
Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
Rhim
Taiyoun
T
Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
Lee
Young Mok
YM
Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
Uh
Soo-Taek
ST
Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
Park
Hae-Sim
HS
Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
Choi
Byoung Whui
BW
Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
Hong
Soo-Jong
SJ
Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea.
Park
Choon-Sik
CS
Asthma Genome Research Group, Soonchunhyang University Hospital, Seoul, South Korea. schalr@schbc.ac.kr.
Shin
Hyoung Doo
HD
Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-gu, Seoul, 110-834, South Korea.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000235:genetics*; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018121:Receptors, Cytokine / Q000235:genetics; D012307:Risk Factors
D017931:DNA Primers; D007377:Interleukin-3; D018121:Receptors, Cytokine