title: The molecular cell biology of head and neck cancer with clinical applications. Section 1: Fundamental biology and the basis of cancer.
abstract: This article addresses the subject of the fundamental workings of the cell. The essential mechanisms that underlie life are discussed and explained as succinctly as intelligibility will allow and the basic principles of molecular and cell biology detailed. In preparing this article I have made reference not only to standard works but also to the most recent research. In the article I attempt to provide both the surgical and medical head and neck oncologist with the basic insights into fundamental oncology necessary to understand and treat the clinical conditions that are head and neck cancer. In addition I hope it will facilitate the understanding of the various evolving novel treatment strategies.
authors.affiliation: Faculty of Medicine, The University of Liverpool, Clincal Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK. profasjones@beestoncastle.fsnet.co.uk
authors.forename: A
authors.initials: A
authors.lastname: Jones
mesh_terms: D017209:Apoptosis / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics; D002462:Cell Membrane / Q000502:physiology; D002875:Chromosomes / Q000235:genetics; D003599:Cytoskeleton / Q000235:genetics; D004247:DNA / Q000737:chemistry; D026942:DNA Topoisomerases / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D005109:Extracellular Matrix / Q000235:genetics; D016161:Genes, Retinoblastoma / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000502:physiology; D016158:Genes, p53 / Q000235:genetics; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D008967:Molecular Biology / Q000379:methods*; D017354:Point Mutation / Q000235:genetics; D011519:Proto-Oncogenes / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics; D016615:Telomere / Q000235:genetics; D018808:Transcription Factor AP-1 / Q000235:genetics; D024363:Transcription Initiation Site / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D015815:Cell Adhesion Molecules; D004272:DNA, Mitochondrial; D018808:Transcription Factor AP-1; D004247:DNA; D026942:DNA Topoisomerases