Phosphoinositides: older than we first thought?
Despite nearly 50 years of study, it is good to see that phosphoinositides are still capable of springing the odd surprise. Signaling by the second messenger phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) was thought to be absent in yeast, but a recent paper now describes the presence of PtdIns(3,4,5)P(3) in Schizosaccharomyces pombe.
Cooke
Frank T
FT
Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. f.cooke@ucl.ac.uk
D019143:Evolution, Molecular; D008954:Models, Biological; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000378:metabolism* / Q000502:physiology; D015290:Second Messenger Systems; D015398:Signal Transduction; D013045:Species Specificity
D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate