Legioliulin, a new isocoumarin compound responsible for blue-white autofluorescence in Legionella (Fluoribacter) dumoffii under long-wavelength UV light.
Legionella dumoffii is one of the causative agents of Legionnaires' disease. There are 50 species in the genus Legionella, of which 10 species including L. dumoffii are known to exhibit uncharacterized blue-white autofluorescence. We constructed an L. dumoffii strain that exhibited a high intensity blue-white fluorescence, isolated a fluorescent pigment from the strain, and determined its molecular formula to be C(19)H(14)O(3) by high-resolution mass spectrometry. An NMR analysis revealed that this was a new isocoumarin compound, which was named legioliulin.
Amemura-Maekawa
Junko
J
Department of Bacteriology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. jmaekawa@nih.go.jp
Hayakawa
Yoichi
Y
Sugie
Hajime
H
Moribayashi
Atsuko
A
Kura
Fumiaki
F
Chang
Bin
B
Wada
Akihito
A
Watanabe
Haruo
H
D003374:Coumarins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism* / Q000528:radiation effects; D007875:Legionella / Q000166:cytology / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects*; D008163:Luminescent Measurements; D008164:Luminescent Proteins / Q000378:metabolism* / Q000528:radiation effects; D008279:Magnetic Resonance Imaging; D008968:Molecular Conformation; D008970:Molecular Weight; D015202:Protein Engineering; D013045:Species Specificity; D014466:Ultraviolet Rays
D003374:Coumarins; D008164:Luminescent Proteins; C493787:legioliulin; C030123:coumarin