Early prediction of changes in weight during six weeks of treatment with antidepressants.
Weight gain is a frequent and important side effect of psychotropic treatment. We sought to determine weight change predictors during treatment with antidepressant drugs. In 24 patients weight, plasma levels of leptin, tumor necrosis factor-alpha (TNF-alpha and soluble TNF receptors were determined longitudinally and a multiple linear regression analysis was used to predict weight change from baseline to the sixth week of treatment. Changes of weight during the first week of treatment, but no other parameter, strongly predicted weight change until endpoint (adjusted R2 = 0.68, F = 50.45, df = 1,23, p < 0.001). Very early changes in weight during treatment with psychotropic drugs might be a simple and clinically useful predictor of future weight development.
Himmerich
Hubertus
H
Max Planck Institute of Psychiatry, Kraepelinstrasse 10, Munich 80804, Germany. himmerich@mpipsykl.mpg.de
Schuld
Andreas
A
Haack
Monika
M
Kaufmann
Christian
C
Pollmächer
Thomas
T
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy; D005260:Female; D005544:Forecasting; D006801:Humans; D020738:Leptin / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D015430:Weight Gain
D000928:Antidepressive Agents; D020738:Leptin; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha