title: LigaSure versus clamp-and-tie thyroidectomy for benign nodular disease.
abstract: BACKGROUND
  LigaSure is an alternative bipolar diathermy system (BDS) combining vessel sealing with reduced thermal spread, which has been successfully used in many abdominal operations; however, there is a little experience in open thyroidectomy. This study compares the efficacy and the advantages of the LigaSure BDS when used for total thyroidectomy for benign thyroid disease with the conventional clamp-and-tie technique.
  
  
  METHODS
  Between May 1998 and October 2002, 517 patients underwent total thyroidectomy for benign thyroid multinodular goiter. Among them, from May 1998 until May 2000, 247 patients (group I) were operated on with the conventional clamp-and-tie technique, whereas from May 2000 until October 2003, 270 patients (group II) underwent total thyroidectomy for benign multinodular goiter with LigaSure BDS through a 4-cm transverse suprasternal incision. Demographics, pathologic characteristics, gland mass, operative time, blood loss, and complications were assessed.
  
  
  RESULTS
  There were no intraoperative complications. Thyroid mass was similar in both groups, but the operative time was shorter in group II than in group I (mean +/- standard deviation, 71 +/- 14 minutes vs 86 +/- 22 minutes; p < .01). Intraoperative total blood loss was similar between the two groups, but postoperative drain volume was less in group II than in group I (21 +/- 15 mL; p < .01). Major post-thyroidectomy complications (ie, laryngeal nerve palsy, hematoma, and hypocalcemia) occurred less frequently in the LigaSure group than in the clamp-and-tie group (0.7%, 0.4%, 1.1% vs 4%, 2%, 4.8%, respectively; p < .05). The mean +/- standard deviation postoperative hospital stay was significantly less for the patients in group II than for those in group I (2.3 +/- 1.7 days vs 2.8 +/- 1.3 days; p < .05).
  
  
  CONCLUSIONS
  The use of the LigaSure vessel sealer for thyroid surgery is an effective and safe alternative that reduces the overall operative time and could be successfully applied through a narrow surgical incision.
authors.affiliation: Department of General Surgery, University General Hospital of Heraklion, University of Crete, 114 Akadimias Avenue, GR-71305, Heraklion Crete, Greece. petrakis@post.com
authors.forename: Ioannis E
authors.initials: IE
authors.lastname: Petrakis
authors.forename: Nektarios E
authors.initials: NE
authors.lastname: Kogerakis
authors.forename: Kostas G
authors.initials: KG
authors.lastname: Lasithiotakis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Vrachassotakis
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Chalkiadakis
mesh_terms: D000328:Adult; D000368:Aged; D003250:Constriction; D004564:Electrocoagulation; D005260:Female; D006044:Goiter, Nodular / Q000601:surgery*; D006801:Humans; D008026:Ligation / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D013965:Thyroidectomy / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome