title: The herbal prescription youkongdan modulates rodent memory, ischemic damage and cortical mRNA gene expression.
abstract: The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and alphaB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice.
authors.affiliation: Jaseng Research Institute of Biotechnology and Bioscience, Seoul, Korea.
authors.forename: Joon Shik
authors.initials: JS
authors.lastname: Shin
authors.forename: Chang Sok
authors.initials: CS
authors.lastname: So
authors.forename: Young Ock
authors.initials: YO
authors.lastname: Kim
authors.forename: Duk Kyun
authors.initials: DK
authors.lastname: Ahn
authors.forename: Kaizhi G
authors.initials: KG
authors.lastname: Sharman
authors.forename: Edward H
authors.initials: EH
authors.lastname: Sharman
mesh_terms: D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002545:Brain Ischemia / Q000517:prevention & control*; D002452:Cell Count / Q000379:methods; D002540:Cerebral Cortex / Q000187:drug effects*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D019587:Dietary Supplements; D004347:Drug Interactions; D051766:Early Growth Response Protein 1; D000091342:Endoplasmic Reticulum Chaperone BiP; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics / Q000378:metabolism; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000072105:Superoxide Dismutase-1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins; C000717248:Hspa5 protein, mouse; D017874:Immediate-Early Proteins; D018832:Molecular Chaperones; D018727:Muscarinic Antagonists; D010936:Plant Extracts; D028321:Plant Preparations; D012333:RNA, Messenger; D014157:Transcription Factors; C493326:youkongdan; D012601:Scopolamine; C000606291:Sod1 protein, mouse; C000606292:Sod1 protein, rat; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D020929:Mitogen-Activated Protein Kinase Kinases