[The effect of "huang lian jie du tang" active fraction on experimental cerebral ischemia].
OBJECTIVE
To study the protective effect of "Huang Lian Jie Du Tang" active fraction (HLJDTAF) on experimental cerebral ischemia.


METHODS
Middle cerebral artery occlusion (MCAO) in rats was used to observe the protective effect of HLJDTAF on ischemia stroke. Common carotid artery occlusion (CCAO) rat was used to analyse the effect of HLJDTAF on blood brain barrier (BBB) permeability. Common carotid artery occlusion and reperfusion repeatedly (CCAORR) in mice were used to test effect of HLJDTAF on gasp time, brain exponential and water content of brain.


RESULTS
HLJDTAF could improve the abnormal behavior of MCAO rats and decrease the infarction area (P < 0. 05, P < 0. 01). HLJDTAF could also significantly prolong the shorten gasp time of CCAORR mice, reduce the brain exponential and decrease the water content in brain (P < 0. 05, P < 0. 01).


CONCLUSIONS
HLJDTAF can protect the brain ischemia injury.
Wu
Yan
Y
Beijing University of Chinese Traditional Medicine, Bejing 100102.
Sun
Jianning
J
Zhang
Ailin
A
Deng
Yun
Y
Shi
Renbing
R
Tan
Tao
T
Sun
Wenyan
W
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001929:Brain Edema / Q000473:pathology / Q000517:prevention & control*; D002545:Brain Ischemia / Q000473:pathology*; D002199:Capillary Permeability / Q000187:drug effects; D002544:Cerebral Infarction / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D014867:Water