Oxygenated diterpenes and other constituents from Moroccan Juniperus phoenicea and Juniperus thurifera var. africana.
Six new diterpenic acids isolated as their methyl ester derivatives, i.e., methyl 12-oxo-8alpha,15-dihydroxyabiet-13-en-19-oate, methyl 12-oxo-8alpha-hydroxyabiet-13-en-19-oate, methyl 15-hydroperoxy-8alpha,12alpha-epidioxiabiet-13-en-19-oate, methyl 15-hydroxy-8alpha,12alpha-epidioxiabiet-13-en-19-oate, methyl 15-hydroperoxy-8alpha,14alpha,12alpha,13alpha-diepoxiabietan-13-en-19-oate, and methyl 7alpha,12beta-dihydroxysandaracopimarate, together with two new isovalerate derivatives of p-methoxycinnamyl alcohol and linalool, were isolated from the leaves of Juniperus thurifera var. africana and Juniperus phoenicea, grown in Morocco. The structures of these compounds were established by using spectroscopic techniques, including 2D NMR spectra. The cytotoxicity of the abietane diterpenoids was tested against five cell lines.
Barrero
Alejandro F
AF
Departamento de Quimica Orgánica, Instituto de Biotecnologia, Facultad de Ciencias, Universidad de Granada, Campus Fuentenueva s/n, 18071-Granada, Spain. afbarre@ugr.es
Quilez del Moral
José F
JF
Herrador
M Mar
MM
Akssira
Mohamed
M
Bennamara
Ahmed
A
Akkad
Said
S
Aitigri
Mohamed
M
D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000032:analysis* / Q000633:toxicity; D018653:Juniperus / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009018:Morocco; D013045:Species Specificity
D004224:Diterpenes