title: [Financial assessment of device for the preparation of intravenous mixtures in hospital pharmacy].
abstract: OBJECTIVE
  To financially assess a device for the preparation of intravenous mixtures (DPIVM) --Grifill system-- such as IV gammaglobulin, salbutamol, ondansetron/dexametasone, cisplatin rehydrating solution and mesna.
  
  
  METHODS
  The most relevant resources used in the preparation and rebottling of each of the above-mentioned intravenous mixtures (for both the DPIVM and the commonly used alternative system) are assessed, as well as unitary costs (obtained from six Spanish hospitals enrolled), and an approach to the real cost by system used is obtained. A sensitivity analysis is performed considering most influencing variables. Results are calculated for one month of system operation.
  
  
  RESULTS
  For IV gammaglobulin, mesna, salbutamol, ondansetron/dexametasone and polyionic solutions DPIVM resulted in financial benefit, but it did not in the preparation of cisplatin rehydrating solution.
  
  
  CONCLUSIONS
  An individualized study in each center is needed to achieve reliable financial data on the system's profitability at hospital pharmacy departments. DPIVM may allow significant financial savings in centers and hospital departments using high-cost pharmaceuticals susceptible of customized dosing --e. g., IV gammaglobulin, other blood derivatives, monoclonal antibodies and/or antibiotics-- or intravenous mixtures requiring pharmaceuticals usually purchased directly from the manufacturer that may be prepared from low-cost raw materials (for instance, salbutamol and polyionic solution) requiring high-quality manipulation (e. g., sterility and precision).
authors.affiliation: Unidad de Bioestadística, Departamento de Salud Pública, Universidad de Barcelona, Barcelona. acasado@3d-healthresearch.com
authors.forename: A
authors.initials: A
authors.lastname: Casado Collado
authors.forename: L
authors.initials: L
authors.lastname: Luengo Pascual
authors.forename: M
authors.initials: M
authors.lastname: Herdman
authors.forename: X
authors.initials: X
authors.lastname: Bonafont Pujol
authors.forename: S
authors.initials: S
authors.lastname: Clemente Bautista
authors.forename: R
authors.initials: R
authors.lastname: Jódar Masanés
authors.forename: V
authors.initials: V
authors.lastname: Napal Lecumberri
authors.forename: G
authors.initials: G
authors.lastname: Serrano Padilla
mesh_terms: D000420:Albuterol; D002945:Cisplatin; D003907:Dexamethasone; D004338:Drug Combinations; D004339:Drug Compounding / Q000191:economics* / Q000295:instrumentation*; D016527:Drug Costs; D017721:Hospital Costs; D006801:Humans; D007262:Infusions, Intravenous / Q000191:economics*; D015080:Mesna; D017294:Ondansetron; D010607:Pharmacy Service, Hospital / Q000191:economics*; D013030:Spain; D005719:gamma-Globulins
chemical_list: D004338:Drug Combinations; D005719:gamma-Globulins; D017294:Ondansetron; D003907:Dexamethasone; D015080:Mesna; D002945:Cisplatin; D000420:Albuterol
vernacular_title: Evaluación económica de un dispositivo para preparación de mezclas intravenosas en farmacia hospitalaria.