Case report: passively acquired anti-D in a D+ pregnant patient.
A sample was submitted for serologic evaluation from a pregnant patient with immune thrombocytopenic purpura (ITP) for possible transfusion in the future because of a decreased platelet count. Anti-D and -E were identified in the patient's serum using several antibody identification techniques, and anti-D was recovered in an acid eluate prepared from the patient's red cells. It was discovered that WinRho had been administered to treat the ITP. This product has been licensed for treatment of nonsplenectomized D+ children and adults with ITP to increase the platelet count. Administration of anti-D to D+ individuals for treatment of ITP can cause a red cell anemia.
Holub
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Blood Systems Laboratories, Immunohematology Services, 6220 E. Oak Street, PO Box 1541, Scottsdale, AZ 85252-1541, USA.
Kitchen
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Mensinger
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