Recent progress in testing the longevity determinant and dysdifferentiation hypotheses of aging.
An overview of the longevity determinant and dysdifferentiation hypotheses is presented, highlighting some of the major postulates and predictions. Results of recent experiments testing these hypotheses are discussed, including the search for specific longevity determinant genes and evidence that cancer and aging may have common causative mechanisms of action and control. Regulation of oxidative stress is considered a potential longevity determinant mechanism and methods and results testing this prediction are reviewed. Possibility of enhancing protective mechanisms against oxidative stress is discussed by way of intervention of central regulatory mechanisms of antioxidants using the cyclase-arachidonic acidcyclooxygenase (GAC model).
Cutler
R G
RG
Gerontology Research Center, Baltimore, MD 21224, U.S.A.