title: A PFG NMR experiment for translational diffusion measurements in low-viscosity solvents containing multiple resonances.
abstract: Pulsed gradient simulated-echo (PGSE) NMR diffusion measurements provide a facile and accurate means for determining the self-diffusion coefficients for molecules over a wide range of sizes and conditions. The measurement of diffusion in solvents of low intrinsic viscosity is particularly challenging, due to the persistent presence of convection. Although convection can occur in most solvent systems at elevated temperatures, in lower viscosity solvents (e.g., short chain alkanes), convection may manifest itself even at ambient laboratory temperatures. In most circumstances, solvent suppression will also be required, and for solvents that have multiple resonances, effective suppression can likewise represent a substantial challenge. In this article, we report an NMR experiment that combines a double-stimulated echo PFG approach with a WET-based solvent suppression scheme that effectively and simultaneously address the issues of dynamic range and the deleterious effects of convection. The experiment described will be of general benefit to studies aimed at the characterization of diffusion of single molecules directly dissolved in low-viscosity solvents, and should also be of substantial utility in studies of supramolecular assemblies such as reverse-micelles dissolved in apolar solvents.
authors.affiliation: Department of Chemistry, University of Utah, Salt Lake City, UT, USA.
authors.forename: Alana K
authors.initials: AK
authors.lastname: Simorellis
authors.forename: Peter F
authors.initials: PF
authors.lastname: Flynn
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D004058:Diffusion; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D014783:Viscosity
chemical_list: D000473:Alkanes; D046911:Macromolecular Substances; D011506:Proteins; D012997:Solvents