[Synthesis and antioxiactivity of squamosamide cyclic analogs].
OBJECTIVE
To design and synthesize a series of squamosamide cyclic analogues and to test their antioxidation activity.


METHODS
Eleven 3-substituted indole-2-one derivatives were designed and synthesized through 9 steps with p-hydroxyphenylacetic acid as the starting material and their structures were confirmed by nuclear magnetic resonance and mass spectrometry.


RESULTS
Eleven compounds showed antioxidation activity and the activities of compounds 9 and 13 matches the positive control FLZ-52.


CONCLUSIONS
Cyclic reconstruction with FLZ-52 as the lead compound have some antioxidation activity.
Xie
Ping
P
Department of Drug Synthesis, Institute of Materia Medica, CAMS and PUMC, Beijing 100050, China. pingxie123@vip.sohu.net
Jiao
Xiao-zhen
XZ
Liang
Xiao-tian
XT
Feng
Wei-hong
WH
Wei
Huai-ling
HL
Liu
Geng-tao
GT
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D044482:Benzeneacetamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D044482:Benzeneacetamides; D010636:Phenols; C084439:squamosamide