title: Impact of regular LDL apheresis on the development of restless legs syndrome.
abstract: We examined 25 hyperlipidaemic patients with coronary heart disease undergoing regular low-density lipoprotein apheresis (LA) treatment in weekly intervals. In this patient population, half were found to have concomitant restless legs syndrome (RLS). Laboratory investigations suggest that iron metabolism is modified by regular LA treatment and this change may be involved in the pathogenesis of this previously unrecognised form of secondary RLS. Substitution of iron therefore may be a promising line of treatment for LA-induced RLS.
authors.affiliation: Department of Clinical Neurophysiology, University of Goettingen, Robert-Koch-Str. 40, 37075 Goettingen, Germany. ttings@med.uni-goettingen.de
authors.forename: Tobias
authors.initials: T
authors.lastname: Tings
authors.forename: Volker
authors.initials: V
authors.lastname: Schettler
authors.forename: Monica
authors.initials: M
authors.lastname: Canelo
authors.forename: Walter
authors.initials: W
authors.lastname: Paulus
authors.forename: Claudia
authors.initials: C
authors.lastname: Trenkwalder
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000453:epidemiology; D001781:Blood Component Removal / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012148:Restless Legs Syndrome / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D012720:Severity of Illness Index; D014168:Transferrin / Q000378:metabolism
chemical_list: D014168:Transferrin; D002097:C-Reactive Protein; D005293:Ferritins