Isolation, structure determination and biological activity of 15-deoxo-7,32-O-didesmethylrapamycin from the soil actinomycete LL-D45042.
Graziani
Edmund I
EI
Department of Chemical & Screening Sciences, Oncology, Wyeth Research, 401 North Middletown Road, Pearl River, New York, 10965, USA. graziaei@wyeth.com
Summers
Mia Y
MY
Janso
Jeffrey E
JE
Yu
Ker
K
Bernan
Valerie S
VS
Greenstein
Michael
M
Carter
Guy T
GT
D039903:Actinobacteria / Q000378:metabolism*; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D012988:Soil Microbiology; D013329:Structure-Activity Relationship
C492085:15-deoxo-7,32-O-didesmethylrapamycin; D020123:Sirolimus