Lipoxygenase inhibitory constituents from Periploca aphylla.
Bisflavan-3-ols 1 and 2 and norterpenoid 3 have been isolated from the methanolic extract of the whole plant of Periploca aphylla. Their structures have been assigned on the basis of spectroscopic analysis including 1D and 2D NMR techniques. In addition, o-phthalic acid bis(2-ethylnonyl) ester (4), 1,3,6-trihydroxy-2,5-dimethoxyxanthone (5), and (+)-lyoniresinol (6) have been reported for the first time from this species. Compounds 1-3 displayed evident inhibitory potential against the enzyme lipoxygenase in a concentration-dependent fashion with IC(50) values 19.7, 13.5, and 150.1 microM, respectively.
Aziz-Ur-Rehman
Aziz-Ur-Rehman
AU
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Malik
Abdul
A
Riaz
Naheed
N
Nawaz
Hafiz Rub
HR
Ahmad
Habib
H
Nawaz
Sarfraz Ahmad
SA
Choudhary
M Iqbal
MI
D003510:Cyclohexanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D031109:Periploca / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C493043:2alpha,6alpha-dihydroxy-5-((E)-3'-hydroxy-3'-methyl-1'-butenyl)-6-methyl-4-cyclohexen-3-one; D003510:Cyclohexanes; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; D013729:Terpenes; C493045:catechin-(3'-O-3''')-afzelechin; C493046:epicatechin-(3'-O-7'')-epiafzelechin