title: Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlates.
abstract: A magnetic-resonance-imaging-based method of cortical parcellation was used to evaluate the morphology of the superior temporal plane and its subregions (Heschl's gyrus [HG], planum temporale [PT], and planum polare [PP]) in a group of 30 patients with schizophrenia versus a matched group of healthy subjects. Right HG volume was significantly reduced in patients compared with control subjects. Each subregion showed a unique set of structure/function relationships: reduced volumes of the HG were associated with greater duration of illness; reduced volumes of the PT were associated with positive symptoms; and in most contrast, elevated volumes of the PP were associated with cumulative neuroleptic exposure.
authors.affiliation: Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
authors.forename: Benedicto
authors.initials: B
authors.lastname: Crespo-Facorro
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Eran
authors.initials: E
authors.lastname: Chemerinski
authors.forename: Vincent
authors.initials: V
authors.lastname: Magnotta
authors.forename: Nancy C
authors.initials: NC
authors.lastname: Andreasen
authors.forename: Peg
authors.initials: P
authors.lastname: Nopoulos
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology*