Evaluation of the GTI-ASP-1 platelet antigen genotyping kit for the determination of the HPA-1 genotype.
The human platelet antigen system HPA-1 is involved in most cases of neonatal alloimmune thrombocytopenia and posttransfusion purpura, and occasionally causes refractoriness to platelet transfusions. Complete concordance was obtained in genotyping for HPA-1 in all samples tested with the HPA-1 genotyping kit and a ligation-based typing method. However, the genotyping kit is less sensitive than ligation- based typing, which could be of importance when testing cells from amnionic fluid or from chorionic villi.
Legler
T J
TJ
Department of Transfusion Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
Hagner
C
C
Köhler
M
M