Non-Hodgkin lymphoma in a child with Williams syndrome.
Non-Hodgkin lymphoma in an 8-year-old boy with Williams syndrome is reported. Molecular DNA analysis showed a maternal deletion at 7q11.23, the locus of elastin and several other genes, including the BCL7B gene, involved in early development. To our knowledge, this is the second reported case of a lymphoma in a Williams syndrome patient and the first in a child.
Amenta
Styliani
S
Medical Genetics, Athens University School of Medicine, Choremio Research Laboratory, Aghia Sophia Children's Hospital, Athens PC 11527, Greece.
Moschovi
Maria
M
Sofocleous
Christalena
C
Kostaridou
Stavroula
S
Mavrou
Ariadni
A
Fryssira
Helen
H
D002051:Burkitt Lymphoma / Q000209:etiology / Q000235:genetics*; D002648:Child; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007078:Ileal Neoplasms / Q000209:etiology / Q000235:genetics; D008297:Male; D011506:Proteins / Q000235:genetics; D018980:Williams Syndrome / Q000150:complications / Q000235:genetics*
C116387:BCL7B protein, human; D011506:Proteins