title: Evaluation of alternative calculation methods for determining low-density lipoprotein cholesterol in hemodialysis patients.
abstract: OBJECTIVE
  To evaluate alternative equations for the estimation of low-density lipoprotein cholesterol (LDL-C) than the Friedewald equation in hemodialysis patients.
  
  
  METHODS
  The equations LDL-C = 0.41TC - 0.14TG + 0.66ApoB - 10.43 and LDL-C = 0.94TC - 0.94HDL-C - 0.19TG were evaluated in 86 patients and compared with the Friedewald equation and the ultracentrifugation procedure.
  
  
  RESULTS
  The alternative equations yield significantly lower bias than the Friedewald equation and are less affected by increased triglycerides (TG) levels.
  
  
  CONCLUSIONS
  The alternative equations for LDL-C yield slightly better results than the Friedewald equation especially in hypertriglyceridemia.
authors.affiliation: Laboratory of Biochemistry, University Hospital, Medical School, University of Ioannina, 451 10, Ioannina, Greece. ebairakt@cc.uoi.gr
authors.forename: Eleni T
authors.initials: ET
authors.lastname: Bairaktari
authors.forename: Christos
authors.initials: C
authors.lastname: Tzallas
authors.forename: M
authors.initials: M
authors.lastname: Kalientzidou
authors.forename: Alexandros D
authors.initials: AD
authors.lastname: Tselepis
authors.forename: Kostas C
authors.initials: KC
authors.lastname: Siamopoulos
authors.forename: Konstantin I
authors.initials: KI
authors.lastname: Seferiadis
authors.forename: Moses S
authors.initials: MS
authors.lastname: Elisaf
mesh_terms: D000328:Adult; D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D006435:Renal Dialysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014280:Triglycerides / Q000097:blood; D014461:Ultracentrifugation
chemical_list: D008078:Cholesterol, LDL; D011933:Reagent Kits, Diagnostic; D014280:Triglycerides