[Anti-lipid peroxidation effect of Rosa davurica Pall. fruit].
OBJECTIVE
To study the anti-lipid peroxidation action of Rosa davurica Pall. fruit.


METHODS
The contents of malondialdehyde (MDA) of the tissue homogenate of the liver, heart, kidney, brain and of the red blood cells induced by hydrogen peroxide in mice were measured. The contents of MDA and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of ischemic myocardium of mice were measured.


RESULTS
0.2 g/L Rosa davurica Pall. fruit could decrease significantly the contents of MDA of the all tissue (P < 0.05). Inhibition rate of 6.7 g/L Rosa davurica Pall. fruit on MDA of the red blood cells induced by hydrogen peroxide was 89.2%. Administration of this extraction successively for six days (ig, 2.0 g x kg(-1) x d(-1)) can significantly reduce the content of MDA (P < 0.01) and augment the activities of SOD and GHS-Px (P < 0.05) in the ischemic myocardium of mice.


CONCLUSIONS
Rosa davurica Pall. fruit can significantly prevent the lipid peroxidation.
Jiao
Shu-Ping
SP
Department of Biochemistry, College of Medicine, Beihua University, Jilin, Jilin Province 132001, China.
Chen
Biao
B
Du
Pei-Ge
PG
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004228:Dithionitrobenzoic Acid; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005638:Fruit / Q000737:chemistry*; D005978:Glutathione / Q000032:analysis / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000032:analysis / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D011897:Random Allocation; D027826:Rosa; D013439:Sulfhydryl Reagents; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D013439:Sulfhydryl Reagents; D008315:Malondialdehyde; D004228:Dithionitrobenzoic Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione