title: Monoclonal gammopathy in extranodal marginal zone lymphoma (ENMZL) correlates with advanced disease and bone marrow involvement.
abstract: Monoclonal gammopathy is a well-recognized occurrence in splenic marginal zone lymphoma (MZL); however, its prevalence has never been reported in extranodal MZL (ENMZL). We present results of a retrospective analysis of 26 patients with newly diagnosed as well as previously treated ENMZL. Monoclonal gammopathy was detected in 7 out of 26 (27%) patients. All patients with a monoclonal gammopathy had stage IV disease, and most of them had involvement of lymph nodes and/or bone marrow (n = 6). Only 1 out of 7 patients with a monoclonal spike had stage IV disease diagnosed based on multifocal mucosal involvement. There was also a strong correlation between the involvement of bone marrow and the presence of a monoclonal spike (Fisher's exact test, P = 0.0007). Prevalence of monoclonal gammopathy is higher than previously recognized and indicates advanced disease. However, the prognostic significance of the presence of monoclonal gammopathy in this population is unknown.
authors.affiliation: Georgetown University Hospital, Departments of Oncology and Medicine, Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA. ea26@georgetown.edu
authors.forename: Ekatherine
authors.initials: E
authors.lastname: Asatiani
authors.forename: Philip
authors.initials: P
authors.lastname: Cohen
authors.forename: Metin
authors.initials: M
authors.lastname: Ozdemirli
authors.forename: Craig M
authors.initials: CM
authors.lastname: Kessler
authors.forename: Blanche
authors.initials: B
authors.lastname: Mavromatis
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Cheson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010265:Paraproteinemias / Q000150:complications / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D007136:Immunoglobulins