title: Effect of combined caries-preventive methods: a systematic review of controlled clinical trials.
abstract: The aim of this systematic review was to evaluate the caries-preventive effect of combined caries-preventive methods, defined as two or more different interventions in combination, each expected to prevent dental caries. The Medline database was searched for articles published in the period January 1966 to June 2003. Twenty-four controlled studies met the inclusion criteria, and their value as evidence was assessed according to predetermined criteria. The level of evidence for the overall conclusion regarding each method was graded according to the protocol of the Swedish Council on Technology Assessment in Health Care. The scientific evidence for the combination of treatments involving fluoride that had a preventive effect on caries in children and adolescents was graded as moderate. However, for elderly patients the scientific evidence for the caries-preventive effect of different combinations of treatments was found to be incomplete. No conclusion could be drawn regarding the evidence for combinations of treatments being effective for groups at high caries risk, as the results from the identified clinical studies were conflicting.
authors.affiliation: The Swedish Council on Technology Assessment in Health Care, Stockholm, Sweden. axelsson@sbu.se
authors.forename: Susanna
authors.initials: S
authors.lastname: Axelsson
authors.forename: Birgitta
authors.initials: B
authors.lastname: Söder
authors.forename: Gunilla
authors.initials: G
authors.lastname: Nordenram
authors.forename: Lars G
authors.initials: LG
authors.lastname: Petersson
authors.forename: Helena
authors.initials: H
authors.lastname: Dahlgren
authors.forename: Anders
authors.initials: A
authors.lastname: Norlund
authors.forename: Carina
authors.initials: C
authors.lastname: Källestål
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Mejàre
authors.forename: Peter
authors.initials: P
authors.lastname: Lingström
authors.forename: Folke
authors.initials: F
authors.lastname: Lagerlöf
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Holm
authors.forename: Svante
authors.initials: S
authors.lastname: Twetman
mesh_terms: D000293:Adolescent; D000368:Aged; D002327:Cariostatic Agents / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D018849:Controlled Clinical Trials as Topic; D003731:Dental Caries / Q000517:prevention & control*; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D009910:Oral Hygiene; D010353:Patient Education as Topic
chemical_list: D002327:Cariostatic Agents; D005459:Fluorides