title: Molecular mechanism of gibberellin signaling in plants.
abstract: The hormone gibberellin (GA) plays an important role in modulating diverse processes throughout plant development. In recent years, significant progress has been made in the identification of upstream GA signaling components and trans- and cis-acting factors that regulate downstream GA-responsive genes in higher plants. GA appears to derepress its signaling pathway by inducing proteolysis of GA signaling repressors (the DELLA proteins). Recent evidence indicates that the DELLA proteins are targeted for degradation by an E3 ubiquitin ligase SCF complex through the ubiquitin-26S proteasome pathway.
authors.affiliation: Department of Biology, Duke University, Durham, North Carolina 27708, USA. tps@duke.edu
authors.forename: Tai-Ping
authors.initials: TP
authors.lastname: Sun
authors.forename: Frank
authors.initials: F
authors.lastname: Gubler
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D005875:Gibberellins / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D063245:Plant Development; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000235:genetics; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D005875:Gibberellins; D010940:Plant Proteins