title: An association between polymorphisms of the interleukin-10 gene promoter and schizophrenia in the Chinese population.
abstract: Immunological abnormalities have been found to be associated with schizophrenia for decades. Cytokines are key proteins involved in the immune system activation. Interleukin-10 (IL-10), an important immunoregulatory cytokine, is located on chromosome 1q31-32, a region previously reported to be linked to schizophrenia in genetic studies. Thus, a study was carried out on the association between schizophrenia and three single nucleotide polymorphisms in the promoter region of IL-10 gene. Totally, 341 patients and 334 controls of Chinese descent were analyzed. Statistically significant differences were observed in both allelic and genotypic frequencies of the -592A/C polymorphism (Allele, chi(2)=4.43, df=1, P=0.032, odds ratio (OR)=1.26, 95% CI 1.02-1.56; Genotype, chi(2)=6.18, df=2, P=0.044) while the other two polymorphisms did not show such differences. The observed haplotype distributions revealed a significant association with schizophrenia (P=0.0008). These data suggest that the IL-10 gene may confer susceptibility to the development of schizophrenia in the Chinese population.
authors.affiliation: Institute of Nutrition Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.forename: Mao-sheng
authors.initials: MS
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.forename: Yong-yong
authors.initials: YY
authors.lastname: Shi
authors.forename: Xin-zhi
authors.initials: XZ
authors.lastname: Zhao
authors.forename: Jian-dong
authors.initials: JD
authors.lastname: Yang
authors.forename: Zhuang-jun
authors.initials: ZJ
authors.lastname: Liu
authors.forename: Niu-fan
authors.initials: NF
authors.lastname: Gu
authors.forename: Guo-yin
authors.initials: GY
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D000483:Alleles; D002681:China; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
chemical_list: D017931:DNA Primers; D016753:Interleukin-10