title: A cytotoxic cyclic heptapeptide from the seeds of Annona cherimola.
abstract: From a methanol extract of the seeds of Annona cherimola, a new cyclic heptapeptide, cherimolacyclopeptide C, has been isolated. The structure was elucidated on the basis of the MS/MS fragmentation using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR experiments, and chemical degradation. Cherimolacyclopeptide C exhibited significant in vitro cytotoxic activity against KB cells, with an IC(50) value of 0.072 microM.
authors.affiliation: Laboratoire de Chimie Organique et Thérapeutique, Faculté de Médecine et de Pharmacie, Université Cheikh Anta Diop Dakar-Fann, Sénégal. alassanewele@yahoo.fr
authors.forename: Alassane
authors.initials: A
authors.lastname: Wélé
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Idrissa
authors.initials: I
authors.lastname: Ndoye
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Brouard
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Pousset
authors.forename: Bernard
authors.initials: B
authors.lastname: Bodo
mesh_terms: D000595:Amino Acid Sequence; D031041:Annona / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013030:Spain
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010456:Peptides, Cyclic; C493122:cherimolacyclopeptide C