title: Fluoxetine-induced memory impairment in four family members.
abstract: OBJECTIVE
  Fluoxetine, a selective serotonin reuptake inhibitor antidepressant agent, has been implicated in learning and memory. Here, we report four cases from the same family of fluoxetine-related memory-impairment.
  
  
  RESULTS
  Memory-impairment resulted after fluoxetine treatment and disappeared after changing to another selective serotonin reuptake inhibitor.
  
  
  CONCLUSIONS
  There may be a relationship between fluoxetine-related memory impairment and genetic factors, and this side-effect appears to be specific to fluoxetine treatment. Possible mechanisms underlying this effect may be the drug's influence on the central serotonergic system or brain-derived neurotrophic factor.
authors.affiliation: Department of Psychiatry, Chung-Shan Medical University Hospital, Taiwan, R.O.C. schwang@gcn.net.tw
authors.forename: Shu-Chi
authors.initials: SC
authors.lastname: Huang
authors.forename: Shih-Jen
authors.initials: SJ
authors.lastname: Tsai
authors.forename: Joseph C C
authors.initials: JC
authors.lastname: Chang
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects*; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008569:Memory Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics; D010641:Phenotype; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors