title: 07H239-A, a new cytotoxic eremophilane sesquiterpene from the marine-derived Xylariaceous fungus LL-07H239.
abstract: 07H239-A (1), a new eremophilane sesquiterpene from a marine-derived xylariaceous fungus, was isolated, characterized, and shown to be cytotoxic toward a variety of cancer cell lines, with some selectivity for a CCRFCEM leukemia line (IC(50) = 0.9 microg/mL).
authors.affiliation: Wyeth-Research, 401 North Middletown Road, Pearl River, New York 10965, USA. mcdonal@wyeth.com
authors.forename: Leonard A
authors.initials: LA
authors.lastname: McDonald
authors.forename: Laurel R
authors.initials: LR
authors.lastname: Barbieri
authors.forename: Valerie S
authors.initials: VS
authors.lastname: Bernan
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Janso
authors.forename: Peter
authors.initials: P
authors.lastname: Lassota
authors.forename: Guy T
authors.initials: GT
authors.lastname: Carter
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C493119:07H239-A; D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; D009281:Naphthalenes; C416822:Sch 420789; D012717:Sesquiterpenes