Structured therapy interruption (STI) and deceptive imprinting.
The immune response in individuals chronically infected with HIV-1 is unable to prevent progression of disease. Diversion of immune recognition via 'Deceptive Imprinting' allows virus variants to continue the infection. Structured Interrupting of (HAART) therapy (STI) causes rebound of virus with 'wild-type' strains that stimulate the immune system. Combining STI with suppression of the dominant response against anti-wild-type virus is proposed to enhance the beneficial effects of STI.
Kohler
Heinz
H
ImmPheron Inc., Lexington, Kentucky 40509, USA. hkohl00@uky.edu
D016915:AIDS Vaccines / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015497:HIV-1 / Q000276:immunology*; D006801:Humans
D016915:AIDS Vaccines