Helicobacter pylori vaccine development based on combined subproteome analysis.
Effective vaccines could provide long-term solutions to many important infectious diseases, however, vaccine development has been hampered by the slow identification of protective antigens. Proteomics provides global information about relevant antigen properties and thus might be ideally suited for identifying promising vaccine antigen subsets. Helicobacter pylori proteomics data are stored in a proteomics database (http://www.mpiib-berlin.mpg.de/2D-PAGE/). In this review, we describe how a combined Helicobacter subproteome analysis resulted in the rapid identification of novel, highly protective antigens. This illustrates the great potential of pathogen proteomics for vaccine development.
Bumann
Dirk
D
Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany. Bumann.Dirk@mh-hannover.de
Jungblut
Peter R
PR
Meyer
Thomas F
TF
D000942:Antigens, Bacterial / Q000737:chemistry; D001428:Bacterial Vaccines / Q000235:genetics*; D019992:Databases as Topic; D015180:Electrophoresis, Gel, Two-Dimensional; D005756:Gastritis / Q000517:prevention & control; D016481:Helicobacter Infections / Q000517:prevention & control; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D020543:Proteome; D040901:Proteomics / Q000379:methods; D014612:Vaccines
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D020543:Proteome; D014612:Vaccines