title: The role of nasal tolerance in a model of IgA nephropathy induced in mice by Sendai virus.
abstract: Mucosal antigenic exposure is implicated in pathogenesis of IgA nephropathy. Although IgG and/or IgM codeposits may promote disease, protracted mucosal antigenic exposure reduces IgG and IgM antibody, a process termed mucosal tolerance. We immunized mice intranasally with infectious or inactivated Sendai virus for 6 or 14 weeks. Anti-virus IgG remained high in mice given infectious virus for 14 weeks, but decreased after 6 weeks in mice given inactivated virus; IgA antibody remained high in both groups. Upon viral challenge, glomerular IgG and complement deposits and the frequency of hematuria, all equal after 6 weeks of immunization, were lower in mice immunized with inactivated virus for 14 weeks but remained high in mice given infectious virus; glomerular IgA increased over time in both immunized groups. Viremia in a non-tolerized immune host can promote glomerulonephritis with IgG and complement codeposits and glomerular dysfunction. These preliminary experiments may guide future, more mechanistic, investigation.
authors.affiliation: Department of Nephrology and Dialysis, Regina Margherita Hospital, Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Amore
authors.forename: R
authors.initials: R
authors.lastname: Coppo
authors.forename: J G
authors.initials: JG
authors.lastname: Nedrud
authors.forename: N
authors.initials: N
authors.lastname: Sigmund
authors.forename: M E
authors.initials: ME
authors.lastname: Lamm
authors.forename: S N
authors.initials: SN
authors.lastname: Emancipator
mesh_terms: D000818:Animals; D005455:Fluorescent Antibody Technique; D006417:Hematuria / Q000276:immunology; D007105:Immune Complex Diseases / Q000276:immunology; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology*; D007668:Kidney / Q000276:immunology; D007674:Kidney Diseases / Q000276:immunology*; D051379:Mice; D011507:Proteinuria / Q000276:immunology; D010253:Respirovirus Infections / Q000276:immunology*; D029082:Sendai virus / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A