title: The unusual transmembrane electron transporter DsbD and its homologues: a bacterial family of disulfide reductases.
abstract: The bacterial membrane protein DsbD transfers electrons across the cytoplasmic membrane to reduce protein disulfide bonds in extracytoplasmic proteins. Its substrates include protein disulfide isomerases and a protein involved in cytochrome c assembly. Two membrane-embedded cysteines in DsbD alternate between the disulfide-bonded (oxidized) and reduced states in this process.
authors.affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Porat
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Cho
authors.forename: Jon
authors.initials: J
authors.lastname: Beckwith
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D004220:Disulfides / Q000737:chemistry; D004579:Electron Transport; D004926:Escherichia coli / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000737:chemistry; D019704:Protein Disulfide-Isomerases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D004220:Disulfides; D009247:NADH, NADPH Oxidoreductases; C014703:disulfide reductase (NADH); D019704:Protein Disulfide-Isomerases