title: Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes.
abstract: Current antibiotic therapy encourages the use of antibiotics that may potentiate the host's immune defences. We therefore investigated the effect of thiamphenicol (TAP), the active principle of thiamphenicol glycinate acetylcysteinate (TGA), on human granulocyte functions, mainly phagocytosis and intracellular killing of Streptococcus pyogenes. Our findings support the use of thiamphenicol in the treatment of respiratory tract infections caused by S. pyogenes as it acts directly against the pathogen as well as in cooperation with PMNs by eliciting their intracellular killing.
authors.affiliation: Department of Public Health and Microbiology, Microbiology Division, University of Turin, Via Santena 9, 10126 Turin, Italy. vivian.tullio@unito.it
authors.forename: Vivian
authors.initials: V
authors.lastname: Tullio
authors.forename: Annamaria
authors.initials: A
authors.lastname: Cuffini
authors.forename: Narcisa
authors.initials: N
authors.lastname: Mandras
authors.forename: Janira
authors.initials: J
authors.lastname: Roana
authors.forename: Giuliana
authors.initials: G
authors.lastname: Banche
authors.forename: Domenico
authors.initials: D
authors.lastname: Ungheri
authors.forename: Nicola
authors.initials: N
authors.lastname: Carlone
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009504:Neutrophils / Q000187:drug effects / Q000382:microbiology / Q000502:physiology*; D010653:Phenylbutazone / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013839:Thiamphenicol / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013839:Thiamphenicol; D010653:Phenylbutazone