[Relationship between genetic polymorphism of tumor necrosis factor-alpha and susceptibility to intrauterine HBV infection].
OBJECTIVE
To study the possible relationship between tumor necrosis factor (TNF)-alpha-238G/A gene polymorphism and the susceptibility to intrauterine HBV infection.


METHODS
Two hundred and fifty-six children, including 130 infants born to HBsAg positive mothers were divided into two groups: forty-five children with intrauterine HBV infection (group I) and 85 children without intrauterine HBV infection (group II), with a control group of 126. TNF-alpha-238G/A gene polymorphism was examined in all 256 children, by means of real-time quantitative fluorescent PCR.


RESULTS
A significant difference of TNF-alpha-238A allele frequency was found between group I and group II (x2=6.797, P=0.009), and between group I and the controls group (x2=0.047, P=0.002), but there was no significant difference between group II and the control groups (x2=0.047, p=0.828).


CONCLUSIONS
This study found that genetic polymorphism of tumor necrosis factor-a was associated with intrauterine HBV infection
Gu
Shao-Qing
SQ
Department of Infectious Diseases, Children's Hospital, Fudan University, Shanghai 200032, China.
Zhu
Qi-Rong
QR
Yu
Hui
H
Fei
Lin-E
LE
Dong
Zuo-Quan
ZQ
Pu
Dong-Po
DP
D000328:Adult; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D006509:Hepatitis B / Q000635:transmission*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors / Q000235:genetics*
C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors