title: Effects of green tea polyphenol on cognitive and acetylcholinesterase activities.
abstract: The effect of tea polyphenol (TP) on cognitive and anti-cholinesterase activity was examined in scopolamine-treated mice. Chronic administration of TP significantly reversed scopolamine-induced retention deficits in both step-through passive avoidance and spontaneous alternation behavior tasks. Furthermore, TP exhibited a dramatic inhibitory effect on acetylcholinesterase activity. This finding suggests that TP might be useful in the treatment of Alzheimer's disease.
authors.affiliation: Department of Food and Biotechnology, Hanseo University, Seosan, Korea. hkkim111@hanseo.ac.kr
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Mija
authors.initials: M
authors.lastname: Kim
authors.forename: Sunki
authors.initials: S
authors.lastname: Kim
authors.forename: Mujo
authors.initials: M
authors.lastname: Kim
authors.forename: Joo Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D008569:Memory Disorders / Q000188:drug therapy; D051379:Mice; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D059808:Polyphenols; D012601:Scopolamine; D013662:Tea / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D012601:Scopolamine; D000110:Acetylcholinesterase