title: Wegener's granulomatosis in pregnancy: a novel approach to management.
abstract: Wegener's granulomatosis rarely is diagnosed in women of childbearing age and is, thus, uncommonly encountered in pregnancy. Although conventional treatment with steroids and cyclophosphamide controls disease activity in 90% of patients, the associated teratogenicity of such a regimen warrants careful consideration in pregnancy. We describe successful remission induction with the use of intravenous immunoglobulin and steroids alone in a woman diagnosed with de novo Wegener's granulomatosis during the first trimester of pregnancy.
authors.affiliation: Department of Nephrology, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia. Rosemary.masterson@mh.org.au
authors.forename: Rosemary
authors.initials: R
authors.lastname: Masterson
authors.forename: Rebecca
authors.initials: R
authors.lastname: Pellicano
authors.forename: Karl
authors.initials: K
authors.lastname: Bleasel
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: McMahon
mesh_terms: D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011261:Pregnancy Trimester, First; D012074:Remission Induction
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D011239:Prednisolone