Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment.
Ferritin regulates iron levels and, for unknown reasons, serum ferritin concentrations are increased in patients at risk for and with acute lung injury (ALI) and multiple organ failure. Uncomplexed iron could exacerbate the toxicity of the increased oxidative stress that occurs in patients with ALI and multiple organ failure and thereby contribute to disease. In the present investigation, the authors found that serum and lung lavage ferritin concentrations increased in hemorrhaged rats that develop ALI as manifested by increased lung inflammation (increased lung lavage leukocyte counts and lung myeloperoxidase activities) and increased lung leak (increased lung lavage protein concentrations). Treatment with mepacrine, a phospholipase A2 inhibitor, attenuated the increases in serum and lung lavage ferritin concentrations, lung inflammation, and lung leak that occur in rats subjected to hemorrhage. The findings show that serum and lung ferritin levels increase and may play a role in the development of acute lung injury caused by hemorrhage.
Yoon-yub
Park
P
The Webb-Waring Institute for Cancer, Aging and Antioxidant Research, Denver, Colorado, USA.
Hybertson
Brooks
B
Wright
Richard
R
Fini
Mehdi
M
Elkins
Nancy
N
Repine
John
J
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005293:Ferritins / Q000097:blood*; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008297:Male; D016877:Oxidants / Q000097:blood; D011014:Pneumonia / Q000097:blood / Q000188:drug therapy / Q000276:immunology; D011796:Quinacrine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000188:drug therapy* / Q000276:immunology
D004791:Enzyme Inhibitors; D016877:Oxidants; D005293:Ferritins; D011796:Quinacrine