title: Sequential assembly strategy for tetrasubstituted olefin synthesis using vinyl 2-pyrimidyl sulfide as a platform.
abstract: We have developed a programmable and diversity-oriented synthetic scheme for tetrasubstituted olefins through a site-selective and sequential assembly of pi-components onto a C=C core of vinyl 2-pyrimidyl sulfide. Noteworthy features are that (i) all components assembled stem from readily available organic halides or their Grignard reagents, (ii) the installation at the desired position can be achieved by the addition of the components in the appropriate order, and (iii) simple alteration of addition order in the sequence results in the production of all possible regio- and stereoisomers of multisubstituted olefins.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan. itami@sbchem.kyoto-u.ac.jp
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Itami
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mineno
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Muraoka
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Yoshida