title: Sequential therapy with caspofungin and fluconazole for Candida albicans infection.
abstract: A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated. Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration. Our data suggest that switching from CAS to FLC is a potentially explorable therapeutic option for treatment of systemic candidiasis.
authors.affiliation: Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliera Umberto I, Via Conca, 60020, Torrette di Ancona, Ancona, Italy. l.infettive@ao-umbertoprimo.marche.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Barchiesi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Spreghini
authors.forename: Isabella
authors.initials: I
authors.lastname: Baldassarri
authors.forename: Anna
authors.initials: A
authors.lastname: Marigliano
authors.forename: Daniela
authors.initials: D
authors.lastname: Arzeni
authors.forename: Daniele
authors.initials: D
authors.lastname: Giannini
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scalise
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D000077336:Caspofungin; D015169:Colony Count, Microbial; D004359:Drug Therapy, Combination; D054714:Echinocandins; D015725:Fluconazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000382:microbiology; D055666:Lipopeptides; D008297:Male; D051379:Mice; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D015725:Fluconazole; D000077336:Caspofungin