title: [Clinical implication of parameter-optimized 3D-FISP MR angiography (MRA) in children with aortic coarctation: comparison with catheter angiography].
abstract: OBJECTIVE
  To implement parameter-optimized 3D-FISP MR angiography (MRA) with interleaved double-slab excitation and to compare the result with catheter angiography in children with aortic coarctation.
  
  
  METHODS
  Eighteen children aged 2 - 15 years (mean 9.1 years) underwent MR imaging on a 1.5T body scanner (Magnetom Vision, Siemens, Germany). All patients had undergone correlative catheter angiography. T1-weighted turbo spin echo (TSE) images (TR 600 ms, TE 17 ms, flip 160 degrees, slice thickness 2 - 4 mm) were obtained in axial and parasagittal orientation, followed by an optimized 3D-FISP MR angiography in a sagittal plane (TR 12.5 ms, TE 5.5 ms, flip 22 degrees, matrix 256 x 256, slice thickness 1.25 mm). All children were sedated but on spontaneous breathing. Image quality was graded by two experienced reviewers using a 4-point scoring system. Source images and reformatted maximum intensity projections (MIP) were analyzed for blood-tissue contrast as well as size and focal stenoses of the aortic arch.
  
  
  RESULTS
  Aortic coarctation was found in 13 of 18 patients, using the 3D-FISP MRA. A high correlation value (r = 0.96) was found compared to catheter angiography. Image quality was high in 94 % with well defined blood-tissue contrast in all cases. The sensitivity to flow and breathing motion was low. Examination time was about 15 minutes depending on volume of interest and heart rate. Diagnostic accuracy has shown improvement using a combined analysis of source and MIP images. The mentioned technique has provided an excellent display of thoracic vasculature.
  
  
  CONCLUSIONS
  MR imaging represents an excellent tool for non-invasive examination of the cardiovascular system of children. The 3D-MRA allows the recording of a large 3D data set without the use of contrast agent and within an adequate measurement period, particularly in small infants unable to hold their breath. In addition, hemodynamic significance of aortic coarctation, the existence of collateral vessels and other congenital heart diseases can be described reliably by using this technique.
authors.affiliation: Radiologische Klinik, Abteilung Radiologische Diagnostik, Eberhard-Karls-Universität Tübingen. ulrich.kramer@med.uni-tuebingen.de
authors.forename: U
authors.initials: U
authors.lastname: Kramer
authors.forename: G
authors.initials: G
authors.lastname: Greil
authors.forename: F
authors.initials: F
authors.lastname: Dammann
authors.forename: F
authors.initials: F
authors.lastname: Schick
authors.forename: S
authors.initials: S
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Fenchel
authors.forename: L
authors.initials: L
authors.lastname: Sieverding
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000792:Angiography / Q000379:methods*; D015901:Angiography, Digital Subtraction; D001017:Aortic Coarctation / Q000175:diagnosis* / Q000503:physiopathology; D002404:Catheterization; D002648:Child; D002675:Child, Preschool; D003097:Collateral Circulation; D003627:Data Interpretation, Statistical; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D012680:Sensitivity and Specificity; D012737:Sex Factors
vernacular_title: Stellenwert einer parameteroptimierten 3D-FISP-MR-Angiographie bei Kindern mit Aortenisthmusstenose im Vergleich zur Katheterangiographie.