[Mechanisms of hypertension in obesity].
Obesity is a chronic disease, considered to be an important risk factor in the development of coronary disease, hypertension, renal insufficiency and failure. Obesity contributes to hypertension by mechanisms such as: insulinic resistance and hyperinsulinaemia, increase of adrenergic activity and of concentrations of aldosterone, retention of sodium and water and increase of cardiac wear, alteration of the endothelial function, through molecules such as leptin and adiponectin and genetic factors. Many paths of research remain open. The angiotensin-converting-enzyme inhibitors (ACEI) and/or the angiotensin II receptor antagonists (ARA II) are first choice medicines because of their beneficial effect on insulinic resistance and sympathetic activity.
López de Fez
C M
CM
Servicio de Medicina Interna, Hospital García Orcoyen, Estella, Navarra. trubiove@cfnavarra.es
Gaztelu
M T
MT
Rubio
T
T
Castaño
A
A
D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D006973:Hypertension / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D007333:Insulin Resistance; D020738:Leptin / Q000502:physiology; D009765:Obesity / Q000150:complications* / Q000628:therapy; D013564:Sympathetic Nervous System / Q000503:physiopathology
D020738:Leptin
Mecanismos de hipertensión en obesidad.