Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts.
We investigated on colon cancer cells the effect of geraniol on thymidylate synthase and thymidine kinase expression, two enzymes related to 5-fluorouracil cytotoxicity. The anti-tumoral efficacy of geraniol and 5-fluorouracil were also evaluated on TC-118 human tumors transplanted in Swiss nu/nu mice. Geraniol (150 microM) but not 5-fluorouracil caused a 2-fold reduction of thymidylate synthase and thymidine kinase expression in cancer cells. In nude mice, the combined administration of 5-fluorouracil (20 mg/kg) and geraniol (150 mg/kg) caused a 53% reduction of the tumor volume, whereas a 26% reduction was obtained with geraniol alone, 5-fluorouracil alone showed no effect.
Carnesecchi
Stephanie
S
Laboratory of Nutritional Oncology, INSERM UMR S 392, IRCAD, 1, place de l'hôpital, 67091 Strasbourg cedex, France.
Bras-Gonçalves
Rui
R
Bradaia
Amyaouch
A
Zeisel
Mirjam
M
Gossé
Francine
F
Poupon
Marie-France
MF
Raul
Francis
F
D000080462:Acyclic Monoterpenes; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D004247:DNA / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009822:Oils, Volatile; D010938:Plant Oils; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013729:Terpenes / Q000008:administration & dosage*; D013937:Thymidine Kinase / Q000235:genetics / Q000378:metabolism; D013940:Thymidylate Synthase / Q000235:genetics / Q000378:metabolism; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D000080462:Acyclic Monoterpenes; D000964:Antimetabolites, Antineoplastic; D009822:Oils, Volatile; D010938:Plant Oils; D012333:RNA, Messenger; D013729:Terpenes; D004247:DNA; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; C007836:geraniol; D005472:Fluorouracil