[A comparison between the effects of periocline and yakang on the treatment of periodontitis].
OBJECTIVE
To compare the efficacy of 2 available periodontal systems for local delivery of antibiotics.


METHODS
26 teeth with moderate to severe periodontitis (PD > or = 4 mm) from 11 patients were selected. The teeth were randomly divided into test group and control group. Periocline (2% minocycline hydrochoride ointment) was applied to the teeth in the test group, while Yakang (local metronidazole) was applied in the control group. The data including clinical indices and microbiological parameters was collected before and on the 7th, 14th day after the therapy.


RESULTS
Before treatment, the mean of each clinical indices and microbiological parameters between the two groups was not different (P > 0.05). But both groups demonstrated significant differences with control after treatment (P < 0.05), while there were no significant differences between the two test groups (P > 0.05).


CONCLUSIONS
Both Periocline and Yakang were effective and secure local delivery drug for treating periodontitis.
Sun
Ying
Y
Dept. of Periodontology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Wu
Ya-fei
YF
Xiao
Xiao-rong
XR
Ding
Yi
Y
Zhu
Zhu
Z
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D008911:Minocycline / Q000627:therapeutic use*; D009824:Ointments / Q000627:therapeutic use; D010518:Periodontitis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D009824:Ointments; D008795:Metronidazole; D008911:Minocycline