title: Novel resistance-nodulation-cell division efflux system AdeDE in Acinetobacter genomic DNA group 3.
abstract: Resistance-nodulation-cell division type efflux pump AdeDE was identified in acinetobacters belonging to genomic DNA group 3. Inactivation of adeE showed that it may be responsible for reduced susceptibility to amikacin, ceftazidime, chloramphenicol, ciprofloxacin, erythromycin, ethidium bromide, meropenem, rifampin, and tetracycline. However, unlike what was found for other similar efflux systems, the open reading frame for the outer membrane component was not found downstream of the adeDE gene cluster.
authors.affiliation: Public Health Laboratory Centre, Department of Health, Hong Kong Special Administrative Region, People's Republic of China.
authors.forename: Sze-Lok
authors.initials: SL
authors.lastname: Chau
authors.forename: Yiu-Wai
authors.initials: YW
authors.lastname: Chu
authors.forename: Elizabeth T S
authors.initials: ET
authors.lastname: Houang
mesh_terms: D000150:Acinetobacter / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D024901:Drug Resistance, Multiple, Bacterial; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial