Sensitization to the psychosis-inducing effects of cocaine compared with measures of cocaine craving and cue reactivity.
A previous study has suggested that sensitization to the psychosis-inducing effects of cocaine may be a marker of vulnerability to relapse in cocaine addiction. In this report, cocaine-dependent subjects participating in a study on naturally occurring and cue-induced cocaine craving were interviewed about prior experience of cocaine-induced psychosis and the degree to which this effect had become more frequent or severe or had occurred at lower cumulative doses. Sensitization to cocaine-induced psychosis was negatively correlated with baseline measures of drug dependence severity and indices of cocaine craving over the preceding 24 hours but not with measures of cocaine cue reactivity.
Reid
Malcolm S
MS
Department of Psychiatry, New York University School of Medicine, New York, NY, USA. malcolm.reid@med.va.gov
Ciplet
Debra
D
O'Leary
Siobhan
S
Branchey
Marc
M
Buydens-Branchey
Laure
L
Angrist
Burt
B
D000328:Adult; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000209:etiology*; D012008:Recurrence
D018765:Dopamine Uptake Inhibitors; D003042:Cocaine