Ethanol targets: a BK channel cocktail in C. elegans.
A genetic screen for resistance to ethanol intoxication in Caenorhabditis elegans isolated mutants of the gene slo-1. slo-1 encodes the pore-forming subunit of a large-conductance Ca(2+)-activated K(+) channel previously shown to limit excitatory neurotransmitter release in C. elegans. Electrophysiological data recorded in vivo are consistent with a model in which ethanol potentiation of SLO-1 produces intoxication in C. elegans by reducing excitatory neurotransmitter release.
Crowder
C Michael
CM
Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Ave, St Louis, MO 63110, USA. crowderm@morpheus.wustl.edu <crowderm@morpheus.wustl.edu>
D000435:Alcoholic Intoxication / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins; D004351:Drug Resistance / Q000187:drug effects / Q000235:genetics; D000431:Ethanol / Q000494:pharmacology*; D051036:Large-Conductance Calcium-Activated Potassium Channels; D008564:Membrane Potentials / Q000187:drug effects / Q000235:genetics; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics; D009154:Mutation / Q000187:drug effects / Q000235:genetics; D009433:Neural Inhibition / Q000187:drug effects / Q000235:genetics; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D024681:Potassium Channels, Calcium-Activated / Q000172:deficiency* / Q000187:drug effects* / Q000235:genetics; D009435:Synaptic Transmission / Q000187:drug effects / Q000235:genetics
D029742:Caenorhabditis elegans Proteins; D051036:Large-Conductance Calcium-Activated Potassium Channels; D024681:Potassium Channels, Calcium-Activated; C494845:slo-1 protein, C elegans; D000431:Ethanol