[Interest of color Doppler ultrasonography to evaluate a new anti-angiogenic treatment with thalidomide in metastatic renal cell carcinoma].
OBJECTIVE
To assess the effectiveness of Doppler Ultrasonography (DUS) in evaluating the anti-angiogenic effect of thalidomide.


METHODS
[corrected] Forty patients with metastases of cancer of the kidney were included in a phase II therapeutic trial. Twenty eight had tumor targets which could be evaluated by DUS. Before treatment, the volume was studied in 59 tumors and the vascularity in 54 tumors. During treatment, comparative DUS examinations were performed every 6 weeks.


RESULTS
Before treatment, the mean tumor volume was 41 cm3, more than 10 vessels were visible in 57% of them. A correlation was noted between the size of the tumors and the degree of vascularity. A stabilisation of tumor volume correlated with a decrease in the number of vessels and an increase in vascularity preceding an increase in tumor volume were also observed.


CONCLUSIONS
DUS is effective in assessing tumour size and vascularity.
Lassau
Nathalie
N
Unité d'échographie, Département d'imagerie, Institut Gustave-Roussy, 39 rue Camille-Desmoulins, 94805 Villejuif, FRANCE. lassau@igr.fr
Chawi
Imad
I
Rouffiac
Valérie
V
Bidault
Sophie
S
Escudier
Bernard
B
Leclère
Jérome
J
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000556:secondary; D006801:Humans; D007680:Kidney Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011446:Prospective Studies; D013792:Thalidomide / Q000627:therapeutic use*; D018615:Ultrasonography, Doppler, Color
D020533:Angiogenesis Inhibitors; D013792:Thalidomide
Intérêt de l'échographie-Doppler pour évaluer l'efficacité d'un traitement anti-angiogénique par thalidomide dans le cancer du rein métastatique.