Expression of the intracisternal A particle endogenous retrovirus genes over the lifetime of mouse and Syrian hamster.
Transcription of intracisternal A particle genes in several tissues has been examined throughout the lifespan of inbred C57BL/6J and outbred wild-type mice and golden Syrian hamster. In both rodent species, expression of the genes occurs at all ages and in all tissues. Also, in both species, RNA transcripts of heterogeneous lengths are found that correspond in size not only to the proviral genes previously characterized but also to genes larger than those reported. In hamster, the size heterogeneity is more extensive than in the mouse, where discrete size transcripts are detectable over the heterogeneous signal. Transcription of these genes throughout the lifespan is not peculiar to the hamster or inbred laboratory mouse strain (C57BL/6J) but also occurs in many tissues of outbred wild-type Mus musculus at each age examined. Lifelong transcription of intracisternal A particle retrovirus genes raises the suggestion that retrovirus proteins and cDNA are continuously produced and could facilitate cumulative genomic rearrangements. This could lead to improper gene regulation and thus contribute to the age-dependent increase of cancer and more generally to the aging process itself.
Brown
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AR
Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, U.S.A.
Ts'o
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Cutler
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RG