title: Characterisation of advanced glycation endproducts in saliva from patients with diabetes mellitus.
abstract: Patients with diabetes mellitus are prone to develop increased advanced glycation endproducts causing local complications and increased overall morbidity and mortality. Nuclear magnetic resonance spectra were determined in saliva of 52 consecutive patients with diabetes mellitus and 47 age-matched healthy control subjects. Resonance spectra showed specific peaks at 2.3, 7.3, and 8.4 ppm in saliva from patients with diabetes mellitus. These peaks could be generated by incubation of saliva from healthy control subjects with hypochloric acid in vitro, indicating the presence of advanced glycation endproducts. The presence of advanced glycation endproducts in patients with diabetes mellitus was associated with approximal plaque index, indicating increased periodontal damage. The study indicates that increased advanced glycation endproducts are involved in the pathogenesis of diabetic complications.
authors.affiliation: Charité--Universitätsmedizin Berlin, Med. Klinik IV, CBF, Berlin, Germany.
authors.forename: Min-Sung
authors.initials: MS
authors.lastname: Yoon
authors.forename: Vera
authors.initials: V
authors.lastname: Jankowski
authors.forename: Susanne
authors.initials: S
authors.lastname: Montag
authors.forename: Walter
authors.initials: W
authors.lastname: Zidek
authors.forename: Lars
authors.initials: L
authors.lastname: Henning
authors.forename: Hartmut
authors.initials: H
authors.lastname: Schlüter
authors.forename: Martin
authors.initials: M
authors.lastname: Tepel
authors.forename: Joachim
authors.initials: J
authors.lastname: Jankowski
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D017127:Glycation End Products, Advanced / Q000032:analysis* / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000175:diagnosis / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced