Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy.
The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.
Reminger
Sheryl L
SL
Department of Pediatrics, University of Arizona, Tucson, AZ, USA. reminger@u.arizona.edu <reminger@u.arizona.edu>
Kaszniak
Alfred W
AW
Labiner
David M
DM
Littrell
Lindsey D
LD
David
Brian T
BT
Ryan
Lee
L
Herring
Anne M
AM
Kaemingk
Kris L
KL
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011788:Quality of Life; D014706:Verbal Learning / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology
D000927:Anticonvulsants