[DNA content and survival in subserous gallbladder carcinoma].
BACKGROUND
The clinical and morphological characterization of the subserous gallbladder carcinomas is controversial.


OBJECTIVE
To study the prognostic importance of DNA content of subserous gallbladder carcinoma.


METHODS
We studied 104 females aged 60+/-12 years old and 16 men aged 70+/-13 years old. In all of them diagnosis was established after mapping of cholecystectomy sample and had a complete clinical follow up. DNA content was measured by flow cytometry.


RESULTS
All tumors were adenocarcinoma, and only 16% were well differentiated. Aneuploidy was observed in 29 cases (26%) with DNA index fluctuating between 1.1 and 1.8. Lymphatic vessel tumor involvement was present in 16 of 22 cases with aneuploidy and in 22 of 46 diploid tumors (p=0.05). Eighty nine percent of aneuploid tumors were detected macroscopically and 11% were unapparent. Five years survival was non significantly better among patients with diploid tumors than in patients with aneuploid tumors (45 and 28%, respectively, p=0.2). The histological differentiation was the only variable significantly associated with survival.


CONCLUSIONS
Aneuploidy is present in 26% of subserous gallbladder carcinoma. It is not related with any of the morphological or clinical variables studied in this series of patients.
Roa
Iván
I
Departamento de Anatomía Patológica, Facultad de Medicina, Universidad de la Frontera. Iroa@ufro.cl
de Aretxabala
Xabier
X
Fuentealba
Patricia
P
Cabrera
María Elena
ME
Araya
Juan C
JC
Roa
Juan
J
D000230:Adenocarcinoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D000368:Aged; D000782:Aneuploidy; D002677:Chile / Q000453:epidemiology; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D005706:Gallbladder Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
D004273:DNA, Neoplasm
Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar.