Antioxidant lignans from Larrea tridentata.
Three lignans, (7S,8S,7'S,8'S)-3,3',4'-trihydroxy-4-methoxy-7,7'-epoxylignan, meso-(rel 7S,8S,7'R,8'R)-3,4,3',4'-tetrahydroxy-7,7'-epoxylignan, and (E)-4,4'-dihydroxy-7,7'-dioxolign-8(8')-ene, together with 10 known compounds, were isolated from the leaves of Larrea tridentata. The structures of the new compounds were determined primarily from 1D and 2D NMR spectroscopic analysis. Their antioxidant activities against intracellular reactive oxygen species were evaluated in HL-60 cells.
Abou-Gazar
Hassan
H
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA.
Bedir
Erdal
E
Takamatsu
Satoshi
S
Ferreira
Daneel
D
Khan
Ikhlas A
IA
D000975:Antioxidants / Q000032:analysis*; D018922:HL-60 Cells; D006801:Humans; D032442:Larrea / Q000737:chemistry*; D017705:Lignans / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
C494253:(7S,8S,7'S,8'S)-3,3',4'-trihydroxy-4-methoxy-7,7'-epoxylignan; C494255:(E)-4,4'-dihydroxy-7,7'-dioxolign-8(8')-ene; D000975:Antioxidants; D017705:Lignans; C494254:meso-(rel 7S,8S,7'R,8'R)-3,4,3',4'-tetrahydroxy-7,7'-epoxylignan