title: Self-healing congenital verruciform hyperkeratosis.
abstract: We report on an apparently previously undescribed neonatal diffuse congenital hyperkeratosis with spontaneous improvement. The child, born to consanguinous parents, presented at birth with a verrucous hyperkeratosis involving face, trunk, and limbs, but sparing palms and soles. No visceral or skeletal abnormality was associated and neurosensory status was normal. The skin condition improved dramatically during the first month of life. At age 7 years, the child was healthy with normal psychomotor development and growth. He had an abnormal curvature of nose, ulerythema ophryogenes, and large ears. The skin was moderately dry. This favorable clinical outcome led us to propose the term "regressive congenital hyperkeratosis" until further molecular characterization of this new phenotype.
authors.affiliation: Unité de Dermatologie Pédiatrique et, Hôpital Pellegrin-Enfants, Place Amelie Raba-Leon, Bordeaux, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Léauté-Labrèze
authors.forename: Franck
authors.initials: F
authors.lastname: Boralevi
authors.forename: Mariane
authors.initials: M
authors.lastname: Cony
authors.forename: Jean
authors.initials: J
authors.lastname: Maleville
authors.forename: Didier
authors.initials: D
authors.lastname: Lacombe
authors.forename: Jean-Etienne
authors.initials: JE
authors.lastname: Surlève-Bazeille
authors.forename: Alain
authors.initials: A
authors.lastname: Taïeb
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007642:Keratosis / Q000151:congenital / Q000235:genetics / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D010375:Pedigree; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure; D014945:Wound Healing