Oxidizing intermediates in cytochrome P450 model reactions.
Oxoiron(IV) porphyrin pi-cation radicals have been considered as the sole reactive species in the catalytic oxidation of organic substrates by cytochromes P450 and their iron porphyrin models over the past two decades. Recent studies from several laboratories, however, have provided experimental evidence that multiple oxidizing species are involved in the oxygen transfer reactions and that the mechanism of oxygen transfer is much more complex than initially believed. In this Commentary, reactive intermediates that have been shown or proposed to be involved in iron porphyrin complex-catalyzed oxidation reactions are reviewed. Particularly, the current controversy on the oxoiron(IV) porphyrin pi-cation radical as a sole reactive species versus the involvement of multiple oxidizing species in oxygen transfer reactions is discussed.
Nam
Wonwoo
W
Department of Chemistry, Division of Nano Sciences, and Center for Biomimetic Systems, Ewha Womans University, 120-750 Seoul, Korea. wwnam@ewha.ac.kr
Ryu
Yon Ok
YO
Song
Woon Ju
WJ
D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000378:metabolism*; D007501:Iron / Q000737:chemistry / Q000378:metabolism; D008665:Metalloporphyrins / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction
D008665:Metalloporphyrins; D009942:Organometallic Compounds; D003577:Cytochrome P-450 Enzyme System; D007501:Iron