Complexation of roxatidine acetate hydrochloride with beta-cyclodextrin: NMR spectroscopic study.
A NMR spectroscopic study of mixtures of varying ratios of roxatidine acetate hydrochloride (RAH) and beta-cyclodextrin (beta-CD) in D2O revealed the formation of a 1:1 inclusion compound. The aromatic ring of RAH selectively penetrates the beta-CD cavity in preference to the piperidine ring.
Ali
S M
SM
Department of Chemistry, Aligarh Muslim University, Aligarh, India. smashhoodali@yahoo.com
Maheshwari
A
A
Asmat
F
F
D000897:Anti-Ulcer Agents / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D017666:Deuterium Oxide / Q000737:chemistry; D005079:Excipients; D009682:Magnetic Resonance Spectroscopy; D010880:Piperidines / Q000737:chemistry*; D047392:beta-Cyclodextrins
D000897:Anti-Ulcer Agents; D003505:Cyclodextrins; D005079:Excipients; D010880:Piperidines; D047392:beta-Cyclodextrins; D017666:Deuterium Oxide; C031215:betadex; C053742:roxatidine acetate