title: BCL-6-positive human herpesvirus 8-associated solid lymphoma arising from liver and spleen as multiple nodular lesions.
abstract: We report a case of BCL-6-positive B cell lymphoma with human herpesvirus 8 (HHV-8) infection. A human immunodeficiency virus-infected patient developed a diffuse large B cell lymphoma, which was found exclusively in the liver and spleen with the absence of lymphadenopathy and effusion in any body cavities. The lymphoma cells were composed of medium to large-sized cells positive for CD20, CD45, and BCL-6, and negative for epithelial cell membrane antigen, CD30, CD45RO, and CD138/syndecan-1, suggesting a germinal center B cell origin. The patient was serologically positive for HHV-8, and HHV-8 was detected in the liver biopsy tissue both by polymerase chain reaction and by immunohistochemistry for HHV-8-encoded latency-associated nuclear antigen. Other HHV-8-associated diseases, such as Kaposi's sarcoma, primary effusion lymphoma, or multicentric Castleman's disease were not detected in the patient. Chemotherapy was effective and reduced the size of the lymphoma dramatically. This is the first case report of a germinal center B cell-originating lymphoma with HHV-8 infection.
authors.affiliation: Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Harutaka
authors.initials: H
authors.lastname: Katano
authors.forename: Masataka
authors.initials: M
authors.lastname: Tanno
authors.forename: Shigeru
authors.initials: S
authors.lastname: Masuo
authors.forename: Takako
authors.initials: T
authors.lastname: Ae
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sato
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takuya
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kurata
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sata
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004268:DNA-Binding Proteins / Q000032:analysis*; D018858:Germinal Center / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000150:complications; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000821:virology*; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000821:virology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D051560:Proto-Oncogene Proteins c-bcl-6; D012074:Remission Induction; D013160:Splenic Neoplasms / Q000473:pathology / Q000821:virology*
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6