Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats.
Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic acid found in beef, lamb, and dairy products. CLA has attracted considerable attention over the past several decades because of its potentially beneficial biologic effects, including protective effects against several cancers, atherosclerosis, and obesity. In previous studies, we provided evidence that dietary CLA could prevent the development of obesity-related hypertension in obese animals. Here, we show that CLA suppresses the development of non-obese essential hypertension in spontaneously hypertensive rats (SHRs). After 4 weeks of feeding with CLA, the increase of systolic blood pressure was significantly suppressed compared with rats fed linoleic acid. Abdominal adipose tissue weight was also significantly lowered in CLA-fed SHRs. Content of arachidonic acid, the substrate of eicosanoid production, was not changed, but accumulation of oleic acid, the lipogenesis end-product, was markedly decreased in the membrane phospholipids of CLA-fed SHRs. In addition, we found increased level of plasma adiponectin, suggested as a regulatory factor of hypertension, through the enhancement of mRNA expression in CLA-fed SHRs. We speculate that the antihypertensive effect of dietary CLA may be due to the increase of plasma adiponectin level and associated with the alleviation of membrane abnormality in SHRs.
Inoue
Nao
N
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan.
Nagao
Koji
K
Hirata
Junichi
J
Wang
Yu-Ming
YM
Yanagita
Teruyoshi
T
D052242:Adiponectin; D000273:Adipose Tissue / Q000187:drug effects* / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D018450:Disease Progression; D005227:Fatty Acids / Q000097:blood; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology* / Q000517:prevention & control*; D036341:Intercellular Signaling Peptides and Proteins; D019787:Linoleic Acid / Q000008:administration & dosage; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000032:analysis; D051381:Rats; D012720:Severity of Illness Index; D016896:Treatment Outcome
D052242:Adiponectin; D000959:Antihypertensive Agents; D005227:Fatty Acids; D036341:Intercellular Signaling Peptides and Proteins; D044243:Linoleic Acids, Conjugated; D011506:Proteins; D019787:Linoleic Acid