Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios.
The glutamate pathways are involved in diverse processes such as learning and memory, epilepsy, and they play important roles in neural plasticity, neural development, and neurodegeneration. It has been proposed that autism could be a hypoglutamatergic disorder. Recently, Jamain et al. reported that the glutamate receptor 6 (GluR6 or GRIK2) is in linkage disequilibrium with autism. In the present study, the transmission disequilibrium test (TDT) and the haplotype transmission were performed to analyze the four SNPs (SNP1: rs995640; SNP2: rs2227281; SNP3: rs2227283; SNP4: rs2235076) of GluR6 in 174 Chinese Han parent-offspring trios. The TDT demonstrated that the two SNPs (SNP2 and SNP3) showed preferential transmission (TDT P = 0.032). The global chi(2) test for haplotype transmission also revealed an association between GluR6 and autism (chi(2) = 10.78, df = 3, P = 0.013). Our results suggested that GluR6 is in linkage disequilibrium with autism.
Shuang
Mei
M
Institute of Mental Health, Peking University, Beijing, China.
Liu
Jing
J
Jia
Mei Xiang
MX
Yang
Jian Zhong
JZ
Wu
Su Ping
SP
Gong
Xiao Hong
XH
Ling
Yan Su
YS
Ruan
Yan
Y
Yang
Xiao Ling
XL
Zhang
Dai
D
D000483:Alleles; D001321:Autistic Disorder / Q000235:genetics*; D002681:China; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009679:Nuclear Family; D020641:Polymorphism, Single Nucleotide; D018092:Kainic Acid Receptors / Q000235:genetics*; D000097806:GluK2 Kainate Receptor
D018092:Kainic Acid Receptors; D000097806:GluK2 Kainate Receptor