title: Fenitrothion-induced changes in lipids of rats.
abstract: The dose-dependent lipid accumulation caused by fenitrothion administration is associated with alteration of the ratio of various components of phospholipids and neutral lipids in various organs of rats up to 48 h. The concentration of triacylglycerol, phosphatidyl choline, phosphatidyl ethanolamine and phosphatidyl glycerol increased in liver, kidney and brain in treated rats whereas phosphatidyl serine was greatly reduced. High-performance liquid chromatography and gas-liquid chromatography were used for quantiative analysis of phospholipids and triacylglycerol. The changes in relative composition of various lipids by fenitrothion administration may lead to malfunctioning and alteration of biological properties.
authors.affiliation: Department of Biotechnology, IIT, Roorkee-247667, India. shalubas2000@yahoo.com
authors.forename: Shalini
authors.initials: S
authors.lastname: Roy
authors.forename: Sharmila
authors.initials: S
authors.lastname: Roy
authors.forename: C B
authors.initials: CB
authors.lastname: Sharma
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005278:Fenitrothion / Q000493:pharmacokinetics / Q000633:toxicity*; D007306:Insecticides / Q000493:pharmacokinetics / Q000633:toxicity*; D007668:Kidney / Q000378:metabolism; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D014018:Tissue Distribution
chemical_list: D007306:Insecticides; D008055:Lipids; D005278:Fenitrothion