title: Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone-related hypercalcemia.
abstract: Ovarian tumors associated with hypercalcemia due to ectopic secretion of parathyroid hormone (PTH) are extremely rare. A 33-year-old woman presented with a pelvic mass and profound hypercalcemia accompanied by an elevated serum level of PTH. Laparotomy demonstrated a left ovarian tumor that on histological examination was a neuroendocrine carcinoma of non-small cell type admixed with a component of endometrioid adenocarcinoma. After left salpingo-oophorectomy, the serum calcium and PTH levels normalized. The cells of the neuroendocrine carcinoma were positive for neuron-specific enolase, synaptophysin, chromogranin A, and PTH. Hypercalcemia and elevated serum PTH levels recurred during tumor relapse, and the patient died of disease 6 months postoperatively. This is the eleventh case of neuroendocrine carcinoma of non-small cell type associated with surface epithelial neoplasm of the ovary, and the first such tumor to be associated with hypercalcemia.
authors.affiliation: Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. osatoshi@hsp.md.shinshu-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohira
authors.forename: Kazuko
authors.initials: K
authors.lastname: Itoh
authors.forename: Tanri
authors.initials: T
authors.lastname: Shiozawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Horiuchi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ono
authors.forename: Haruka
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Waki
authors.initials: W
authors.lastname: Hosoda
authors.forename: Ikuo
authors.initials: I
authors.lastname: Konishi
mesh_terms: D002118:Calcium / Q000097:blood; D018269:Carcinoma, Endometrioid / Q000378:metabolism / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D009384:Paraneoplastic Endocrine Syndromes / Q000150:complications / Q000473:pathology*; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium