Delayed hemolytic transfusion reaction due to anti-Fyb caused by a primary immune response: a case study and a review of the literature.
Delayed hemolytic transfusion reactions (DHTRs) usually occur between 3 and 14 days posttransfusion as a result of a secondary immune response, with a drop in Hb level, fever, jaundice, or hemoglobinuria. DHTRs caused by a primary immune response are particularly rare events, and only a few reports have been known. In this report, we describe an unusual case of a DHTR caused by anti-Fyb in a 42-year-old man, who had no prior history of transfusion. Although it seems to be a rare phenomenon, we suggest that DHTRs by a primary immune response may be considered even in the case of the patient who had typical evidence of hemolysis but who had no previous transfusion history.
Kim
H H
HH
Department of Laboratory Medicine, College of Medicine, Pusan National University, 1-10 Ami-dong, Seo-gu, Busan 602-739, Korea.
Park
T S
TS
Oh
S H
SH
Chang
C L
CL
Lee
E Y
EY
Son
H C
HC
D000328:Adult; D000743:Anemia, Hemolytic / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D004375:Duffy Blood-Group System / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D007519:Isoantigens / Q000009:adverse effects* / Q000276:immunology*; D008297:Male; D013997:Time Factors; D065227:Transfusion Reaction
D004375:Duffy Blood-Group System; D007518:Isoantibodies; D007519:Isoantigens