title: Criteria for neuropathic abnormality in quantitative anal sphincter electromyography.
abstract: For the external anal sphincter muscle, both normative values and an optimal set of motor unit potential (MUP) parameters have been defined. However, criteria for the diagnosis of neuropathic conditions have not yet been validated. Therefore, in this study, sensitivity was examined in 86 patients with cauda equina lesions (227 muscles), and specificity in 77 controls (119 muscles), using multi-MUP analysis. Six previously defined diagnostic criteria (mean values and outliers for MUP area, duration, and number of turns) were used. An increase in the number of diagnostic criteria required for muscle abnormality (two and three instead of one), and the application of more stringent normative limits resulted in a progressive increase in specificity from 74% to 99% (controls), and a decrease in sensitivity from 70% to 21% (patients). The data suggest that no single cut-off diagnostic criterion has both satisfactory sensitivity and specificity. Introduction of the diagnostic categories of "possible," "probable," and "definite" neuropathic abnormalities into quantitative electromyographic analysis is proposed.
authors.affiliation: Institute of Clinical Neurophysiology, Division of Neurology, University Medical Center Ljubljana, SI-1525 Ljubljana, Slovenia. simon.podnar@kclj.si <simon.podnar@kclj.si>
authors.forename: Simon
authors.initials: S
authors.lastname: Podnar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000002:abnormalities* / Q000033:anatomy & histology / Q000502:physiology*; D002420:Cauda Equina / Q000002:abnormalities; D016001:Confidence Intervals; D004576:Electromyography / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011128:Polyradiculopathy / Q000175:diagnosis* / Q000503:physiopathology*