Effect of environmental fluctuations on the dynamic composition of engineered cartilage: a deterministic model in stochastic environment.
Dynamics of extracellular matrix (ECM) deposition and scaffold degradation in cell-polymer constructs have been studied in a random fluctuating environment created due to the applications of growth factors into the in vitro generation of cartilaginous constructs. Existing models of cell-polymer constructs for the design of engineered cartilage have been discussed and then a new deterministic scheme in random environment proposed taking into account the effects of growth factors as the environmental variability in the form of Gaussian white noise. Steady-state probability distribution of each individual component of the ECM in its homeostasis is found explicitly. The computer-simulated results of the model have been discussed and then compared with the data from a variety of scaffold systems and culture conditions.
Saha
A K
AK
IRIS, Swinbume University of Technology, PO Box 218, Hawthorn, Melbourne, Vic. 3122, Australia.
Mazumdar
J N
JN
Morsi
Y S
YS
D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000502:physiology*; D018929:Cell Culture Techniques / Q000379:methods; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology*; D003198:Computer Simulation; D004777:Environment; D005109:Extracellular Matrix / Q000502:physiology* / Q000648:ultrastructure; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D013269:Stochastic Processes; D023822:Tissue Engineering / Q000379:methods*
D016326:Extracellular Matrix Proteins