title: Left atrioventricular plane displacement but not left ventricular ejection fraction is influenced by the degree of aortic stenosis.
abstract: OBJECTIVE
  To examine how left atrioventricular plane displacement (AVPD), a widely used measure of left ventricular (LV) function, is related to presence and degree of aortic stenosis.
  
  
  RESULTS
  Cardiac dimensions, LV filling, left AVPD, LV ejection fraction (LVEF), and valve function were assessed by echocardiography/Doppler in 182 patients with various cardiac diseases (mean (SD) age 69 (12) years, 36% women), 49 consecutive with and 133 consecutive without aortic stenosis. In an analysis of covariance, neither left AVPD nor LVEF was independently correlated with the presence of aortic stenosis. However, looking separately at patients with aortic stenosis, left AVPD (p = 0.03) but not LVEF correlated independently with degree of aortic stenosis in multiple linear regression analysis. In patients with aortic stenosis, an abnormal left AVPD had 94% sensitivity and 90% negative predictive value with regard to severe aortic stenosis, compared with 56% and 62%, respectively, for LVEF.
  
  
  CONCLUSIONS
  In patients with cardiac disease, neither left AVPD nor LVEF correlated independently with presence of aortic stenosis. However, in patients with aortic stenosis, left AVPD but not LVEF correlated with the degree of aortic valve obstruction and left AVPD but not LVEF had high sensitivity and negative predictive value with regard to severe aortic stenosis. Compared with LVEF, left AVPD is an earlier and more sensitive marker of LV haemodynamic load in patients with aortic stenosis.
authors.affiliation: Department of Cardiology, Malmö University Hospital, S-205 02 Malmö, Sweden. erik.rydberg@medforsk.mas.lu.se
authors.forename: E
authors.initials: E
authors.lastname: Rydberg
authors.forename: P
authors.initials: P
authors.lastname: Gudmundsson
authors.forename: L
authors.initials: L
authors.lastname: Kennedy
authors.forename: L
authors.initials: L
authors.lastname: Erhardt
authors.forename: R
authors.initials: R
authors.lastname: Willenheimer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016277:Ventricular Function, Left / Q000502:physiology*