A case of severe chronic active Epstein-Barr virus infection with T-cell lymphoproliferative disorder.
Chronic infection with Epstein-Barr virus (EBV) without previous immunodeficiency or immuno-suppressive therapy is relatively rare. Severe chronic active EBV (SCAEBV) infection was reported for the first time in 1984 as 'chronic mononucleosis syndrome', and diagnostic criteria were proposed. It is characterized by clinical features including fever, severe hepatosplenomegaly, lymphadenopathy, hematologic features such as anemia and thrombocytopenia, and elevated antibody titers to EBV. We experienced a 21-year-old woman who initially presented with fever and chronic fatigue; however, no definite diagnosis could be made at the time of admission. Three months after the initial admission, there was evidence of only splenomegaly and the patient had persistent, multiple, paraaortic lymphadenopathies in abdominal CT. Diagnostic splenectomy was performed, and SCAEBV infection with T-cell lymphoproliferative disorder was ultimately diagnosed.
Cho
Hyun Seok
HS
Department of Internal Medicine and Pathology, Hanyang University College of Medicine, Seoul, Korea.
Kim
In Soon
IS
Park
Hwan Cheol
HC
Ahn
Myung Ju
MJ
Lee
Young Yiul
YY
Park
Chan Kum
CK
D000328:Adult; D002908:Chronic Disease; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012720:Severity of Illness Index; D013156:Splenectomy; D013601:T-Lymphocytes; D014057:Tomography, X-Ray Computed