title: Solid-phase chemoenzymatic synthesis of C-sialosides.
abstract: The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.
authors.affiliation: Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
authors.forename: Sultan N
authors.initials: SN
authors.lastname: Baytas
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.forename: Nathalie A
authors.initials: NA
authors.lastname: Karst
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Dordick
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Linhardt
mesh_terms: D000215:Acylation; D006027:Glycosides / Q000138:chemical synthesis*; D008956:Models, Chemical; D015394:Molecular Structure; D009438:Neuraminic Acids / Q000737:chemistry*; D009439:Neuraminidase / Q000037:antagonists & inhibitors
chemical_list: D006027:Glycosides; D009438:Neuraminic Acids; D009439:Neuraminidase