Using genetic admixture to study the biology of obesity traits and to map genes in admixed populations.
Differences among ethnic and racial groups in obesity-related traits have been clearly established in the scientific literature. To explore the genetic component underlying these differences, the genetic admixture approach has been used. In this approach, ancestry informative genetic markers are used to estimate a quantitative value representing the degree of ancestral background in individuals of admixed genetic background. Genetic admixture has been successfully used to explain racial and ethnic variation in obesity related traits; however, the understanding and measure of cultural and environmental components that also influence these phenotypes still requires further exploration.
Fernández
José R
JR
Division of Physiology and Metabolism, Department and Nutrition Sciences, University of Alabama at Birmingham, 1530 3rd Ave S, Birmingham, AL 35294-3360, USA.
Shiver
Mark D
MD
D044467:American Indian or Alaska Native / Q000235:genetics; D044383:Black People / Q000235:genetics; D002874:Chromosome Mapping; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D009765:Obesity / Q000208:ethnology / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D044465:White People / Q000235:genetics
D005819:Genetic Markers