title: Elimination rate constants of 46 polycyclic aromatic hydrocarbons in the unionid mussel, Elliptio complanata.
abstract: Elimination rate constants (k2), biological half-lives (t(1/2)), and the time required to reach 95% of steady-state (t95) are reported for 46 individual polycyclic aromatic hydrocarbons (PAHs) including both parent and alkyl homologues, for the freshwater unionid mussel, Elliptio complanata. Elimination rate constants generally follow first-order kinetics and range from 0.04/day (d) for perylene to 0.26/d for 2,6-dimethylnapthalene, half-lives range from 2.6 to 16.5 d, and t95 values range from 11.3 to 71.3 d. These values compare well with other k2, t(1/2), and t95 values reported in the literature for PAHs and other classes of hydrophobic organic contaminants. A linear regression of k2 versus log Kow demonstrates dependence of PAH elimination on hydrophobicity, as measured by an r2 value of 0.83, and produces the following regression equation: k2 = -0.06 (log Kow) + 0.44. This study provides evidence that mussels experiencing different forms of physiological stress (e.g., handling stress and fungal or bacterial growth) can exhibit large variation in toxicokinetic parameters. These results are particularly relevant to the extrapolation of laboratory results to field situations.
authors.affiliation: Department of Environmental and Molecular Toxicology, North Carolina State University, Box 7633, Raleigh, North Carolina 27695, USA. Wathorsen@hotmail.com
authors.forename: W A
authors.initials: WA
authors.lastname: Thorsen
authors.forename: D
authors.initials: D
authors.lastname: Forestier
authors.forename: T
authors.initials: T
authors.lastname: Sandifer
authors.forename: P R
authors.initials: PR
authors.lastname: Lazaro
authors.forename: W G
authors.initials: WG
authors.lastname: Cope
authors.forename: D
authors.initials: D
authors.lastname: Shea
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000150:complications / Q000662:veterinary; D049872:Bivalvia / Q000382:microbiology / Q000502:physiology*; D006207:Half-Life; D006304:Health Status; D007700:Kinetics; D009181:Mycoses / Q000150:complications / Q000662:veterinary; D011084:Polycyclic Aromatic Hydrocarbons / Q000493:pharmacokinetics*; D012016:Reference Values; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics*
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical