Significant effects of diacylglycerol on body fat and lipid metabolism in patients on hemodialysis.
OBJECTIVE
The long-term effects of dietary diacylglycerol (DAG) on body fat and lipid metabolism were studied in patients undergoing hemodialysis (HD).


METHODS
Ten patients (seven males, three females) ranging in age from 40 to 64 years were enrolled. During the test period, 9.8 g of DAG was ingested per day for 3 months.


RESULTS
Body mass index did not change throughout the study. The abdominal fat area measured by CT scan decreased significantly at 3 months, and increased significantly 3 months after completion of the DAG ingestion period. The serum composition of very low-density lipoprotein (VLDL) decreased significantly at 3 months and high-density lipoprotein (HDL) increased significantly at 3 months; these were determined using polyacrylamide gel electrophoresis. Serum lipoprotein (a) decreased significantly at 3 months.


CONCLUSIONS
Our study showed that 3-month ingestion of DAG reduced the amount of abdominal fat and improved serum lipid profiles in free-living HD patients.
Teramoto
T
T
Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173-8605, Japan.
Watanabe
H
H
Ito
K
K
Omata
Y
Y
Furukawa
T
T
Shimoda
K
K
Hoshino
M
M
Nagao
T
T
Naito
S
S
D000005:Abdomen / Q000033:anatomy & histology; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000328:Adult; D001823:Body Composition / Q000187:drug effects* / Q000502:physiology; D004075:Diglycerides / Q000008:administration & dosage*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D004075:Diglycerides; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL