title: A case of antiphospholipid syndrome presenting with pulmonary truncus and main pulmonary artery thrombosis.
abstract: In patients with antiphospholipid syndrome (APS), thromboembolism and pulmonary hypertension are the most common pulmonary manifestations. Thrombotic obstruction at the level of the main and/or proximal pulmonary arteries is rare. We report a 40-year-old woman without any history of previous arterial and/or venous thrombosis who presented with severe dyspnea and was found to have pulmonary hypertension and positivity for anticardiolipin antibodies. Computed tomography revealed pulmonary truncus thrombosis extending to both right and left pulmonary arteries. The patient and her family refused surgical treatment. She had a prolonged hospital course, was unresponsive to thrombolytic, anticoagulant, antiplatelet, and immunosuppressive treatments, and died of right ventricle and respiratory failure 5 weeks later. This is the first reported case with thrombosis of pulmonary truncus and main pulmonary arteries concurrent with APS.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Division of Internal Medicine, Yuzuncu Yil University Medical Faculty, Van, Turkey. sayarli@hotmail.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sayarlioglu
authors.forename: Nazan
authors.initials: N
authors.lastname: Topcu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Harman
authors.forename: Unal
authors.initials: U
authors.lastname: Guntekin
authors.forename: Reha
authors.initials: R
authors.lastname: Erkoc
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications / Q000473:pathology*; D003937:Diagnosis, Differential; D004452:Echocardiography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000473:pathology; D011651:Pulmonary Artery / Q000473:pathology*; D011655:Pulmonary Embolism / Q000209:etiology / Q000473:pathology*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D017153:Antibodies, Anticardiolipin