title: Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors.
abstract: Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase.
authors.affiliation: UPRES EA 1085 Biomolécules et Cibles Cellulaires Tumorales, Faculté de Pharmacie, 2 rue du Docteur Marcland, 87025 Limoges, France.
authors.forename: Samir
authors.initials: S
authors.lastname: Yahiaoui
authors.forename: Christelle
authors.initials: C
authors.lastname: Pouget
authors.forename: Catherine
authors.initials: C
authors.lastname: Fagnere
authors.forename: Yves
authors.initials: Y
authors.lastname: Champavier
authors.forename: Gérard
authors.initials: G
authors.lastname: Habrioux
authors.forename: Albert José
authors.initials: AJ
authors.lastname: Chulia
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047072:Aromatase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D010920:Placenta / Q000648:ultrastructure; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D047309:Flavones; D014230:Triazoles