title: Pantoprazole-induced acute interstitial nephritis.
abstract: Pantoprazole is a proton-pump inhibitor (PPI) that is commonly prescribed for the treatment of gastroesophageal reflux-related disorders. There are many documented side effects of PPIs. Here we report a case of acute interstitial nephritis, which developed after 6 weeks of treatment with pantoprazole. A 23-year-old man presented with acute renal failure requiring renal replacement therapy. Acute interstitial nephritis was diagnosed by renal biopsy and was successfully treated with corticosteroids and withdrawal of pantoprazole. Drug-induced acute interstitial nephritis can occur with PPIs such as pantoprazole and vigilance needs to be maintained.
authors.affiliation: Department of Nephrology, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
authors.forename: Iain
authors.initials: I
authors.lastname: Moore
authors.forename: John A
authors.initials: JA
authors.lastname: Sayer
authors.forename: Anitha
authors.initials: A
authors.lastname: Nayar
authors.forename: Saeed
authors.initials: S
authors.lastname: Ahmed
authors.forename: John S
authors.initials: JS
authors.lastname: Tapson
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D001562:Benzimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D009853:Omeprazole / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077402:Pantoprazole; D018570:Risk Assessment; D013454:Sulfoxides / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; D007166:Immunosuppressive Agents; D013454:Sulfoxides; D000077402:Pantoprazole; D009853:Omeprazole