Organic nanoparticles whose size and rigidity are finely tuned by cross-linking the end groups of dendrimers.
Dendrimers with molecular weights ranging from ca. 2700 to 11 000 and from 16 to 64 homoallyl ether end groups were cross-linked using the Grubbs ring-closing metathesis reaction. A combination of SEC, MALDI-TOF-MS, and AFM were used to characterize the cross-linked nanoparticles. The data suggest a significant decrease in volume with cross-linking and a concomitant increase in rigidity, both of which can be controlled independently with a fair degree of precision.
Lemcoff
N Gabriel
NG
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Matthews Avenue, Urbana, IL 61801, USA.
Spurlin
Tighe A
TA
Gewirth
Andrew A
AA
Zimmerman
Steven C
SC
Beil
James B
JB
Elmer
Stephanie L
SL
Vandeveer
H George
HG
D003432:Cross-Linking Reagents / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D008970:Molecular Weight; D036103:Nanotechnology; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D003432:Cross-Linking Reagents; D004987:Ethers; D011108:Polymers