[The antitumor activities of the extracts from Stellera chamaejasmel L. in vitro by means of systematic solvent extraction].
OBJECTIVE
To screen the antitumor extract from Stellera chamaejasmel L..


METHODS
The means of systematic solvent extraction was used to separate the 95% ethanol extract. The antitumor activities of the different extracts in vitro were analyzed with MTT assay.


RESULTS
The petroleum ether extract and the chloroform extract strongly inhibited cell proliferation of human cancer cell lines such as leukemia HL-60, stomach cancer SGC-7901 and hepatocarcinoma BEL-7402, and showed significant dose-dependent response while the n-butanol extract and the methanol extract exhibited low antitumor activities in vitro. The petroleum ether extract was most active.


CONCLUSIONS
The petroleum ether extract is the principal antitumor extract from Stellera chamaejasmel L..
Wang
Bin
B
School of Life Science, Lanzhou University, Lanzhou 730000.
Wang
Rui
R
Jia
Zhengping
Z
Fan
Junjie
J
Ma
Jun
J
Zhang
Ruxue
R
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003124:Colorimetry / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry*; D013274:Stomach Neoplasms / Q000473:pathology*; D029645:Thymelaeaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal