Lipid, sugar and liposaccharide based delivery systems 2.
The vast majority of biologically active compounds will never be considered as potential drugs due to inherently poor bioavailability. This review discusses the progress in the development of chemical systems to improve the metabolic stability, absorption and physicochemical properties of potential drugs. Delivery systems that involve the conjugation of lipid and/or sugar moieties are highlighted, as well as novel methods of conjugation of these groups to drugs. The use of sugar molecules to target drugs to particular organs or cells is also discussed, as is the use of lipids in the growing area of gene delivery. This is an update of a previous review.
Blanchfield
J
J
School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Toth
I
I
D000042:Absorption; D002241:Carbohydrates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004355:Drug Stability; D008055:Lipids / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry*; D009841:Oligonucleotides / Q000008:administration & dosage / Q000737:chemistry; D004364:Pharmaceutical Preparations; D012995:Solubility
D002241:Carbohydrates; D008055:Lipids; D008070:Lipopolysaccharides; D009841:Oligonucleotides; D004364:Pharmaceutical Preparations