Serum creatinine levels in 10-year survivors of cadaveric kidney transplants.
A yearly history of serum creatinine levels was made in a selected cohort of cadaver donor transplant patients who survived 10 years. 1. A stepwise increase in serum creatinine levels was noted with increasing age of the donor. 2. A similar increase was found with increasing recipient weight. 3. In all analyses of kidney size in relation to recipient weight, such as sex of the donor and races, a corresponding relationship to the serum creatinine was noted. That is, whenever the kidney was smaller, or the recipient was larger, an increased level of serum creatinine was found. 4. Rejection at discharge and cold ischemia time had a small long-term effect on serum creatinine levels. Kidneys from donors who had a stroke had higher serum creatinine levels than those who died of anoxia or head trauma. 5. In general, patients with polycystic kidney disease had the lowest serum creatinine levels, whereas those with SLE and GN had higher serum creatinine levels. 6. Patients with 0-A,B,DR mismatched kidneys had the lowest serum creatinine levels every year from the first year on through the tenth year. 7. The rates at which serum creatinine increases with time was established for patients with various original diseases, as well as in the total population. The increase in serum creatinine levels in those who failed after 5 years was similar to those who failed in 10 years.
Mizutani
Kazuo
K
Terasaki Foundation Laboratory, Los Angeles, California, USA.
Terasaki
Paul I
PI
D000367:Age Factors; D003404:Creatinine / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000208:ethnology / Q000601:surgery; D016030:Kidney Transplantation / Q000706:statistics & numerical data; D008297:Male; D012042:Registries; D012737:Sex Factors; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data
D003404:Creatinine