title: Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides.
abstract: Analysis of the exon-intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significantly enriched in phase 1 proto-splice sites and this has favored insertion of spliceosomal introns in these sites.
authors.affiliation: Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Karolina út 29, P.O. Box 7, Budapest H-1518, Hungary.
authors.forename: Hedvig
authors.initials: H
authors.lastname: Tordai
authors.forename: László
authors.initials: L
authors.lastname: Patthy
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D021382:Protein Sorting Signals / Q000235:genetics; D022821:RNA Splice Sites; D012326:RNA Splicing; D017381:Spliceosomes / Q000235:genetics* / Q000378:metabolism
chemical_list: D021382:Protein Sorting Signals; D022821:RNA Splice Sites