title: No association of IL-1beta C + 3954 T polymorphism and thyroid disease.
abstract: Interleukin-1 is a potent pro inflammatory agent, has a direct influence on human thyroid cell function, and modulates cell growth in differentiated thyroid carcinoma cell lines. To evaluate whether a polymorphism on the IL-1beta gene has an influence on the incidence of thyroid disorders, we analyzed the C + 3954 T polymorphism in DNA samples of 673 individuals. 414 venous blood samples were collected from patients suffering from thyroid diseases (Graves' disease n = 53, euthyroid or hyperthyroid non-immunogenic benign thyroid disorders n = 240, thyroid carcinoma n = 121). 259 persons without thyroid disease served as a control. There was no statistically significant association between either of the thyroid alterations or functional conditions on the one hand and the examined genetic polymorphism on the other. Because of the large number of samples tested we can conclude with a high degree of confidence that there is no association between the genotype and the surveyed diseases.
authors.affiliation: Department of General and Visceral Surgery, Heinrich-Heine-University, Düsseldorf, Germany. Ira.Reichmann@uni-duesseldorf.de
authors.forename: I
authors.initials: I
authors.lastname: Reichmann
authors.forename: K M
authors.initials: KM
authors.lastname: Schulte
authors.forename: H D
authors.initials: HD
authors.lastname: Roeher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013959:Thyroid Diseases / Q000235:genetics*
chemical_list: D007375:Interleukin-1