Community-based study in Taiwan aborigines concerning renal dysfunction in gout patients.
OBJECTIVE
To reveal the factors associated with renal dysfunction among gout patients in Taiwan aborigines.


METHODS
Social demographic data, alcohol consumption data, anthropometric measurements, blood samples, and 24-h urine samples were collected from 128 aboriginals (101 men, 27 women) suffering from gout.


RESULTS
The men displayed higher mean creatinine clearance (Ccr) values than women. Twenty-two post-menopausal women had significantly lower Ccr values compared to the five pre-menopausal women [probability (p)<0.001]. The males displayed higher 24-h urinary creatinine value than females (8.60+/-5.39 versus 5.58+/-2.14 mmol/L; p<0.05), and showed a significantly higher positive relationship between 24-h urinary creatinine and uric acid excretion [correlation coefficient (r)=0.7304; p<0.001], whereas the females did not (r=0.1144; p=0.5691). Overall, those who were older members of the Tsou tribe, or had excreted less uric acid from urine in 24 h tended to suffer renal dysfunction.


CONCLUSIONS
Gout patients displayed diversity in renal function. An exogenous source of creatinine in men was more likely than in women.
Chang
S J
SJ
Department of Public Health, School of Medicine, Kaohsiung Medical University, Taiwan.
Chen
C J
CJ
Hung
H P
HP
Ou
T T
TT
Ko
Y C
YC
D000328:Adult; D000368:Aged; D000886:Anthropometry; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006073:Gout / Q000150:complications* / Q000208:ethnology*; D006306:Health Surveys; D006801:Humans; D007674:Kidney Diseases / Q000208:ethnology* / Q000209:etiology*; D008297:Male; D008593:Menopause; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D013624:Taiwan
D003404:Creatinine