Receptor editing in positive and negative selection of B lymphopoiesis.
In B lymphopoiesis, Ag receptor expression and signaling are critical to determine developmental progression, survival, and activation. Several positive and negative selection checkpoints to test this receptor have been described in B lymphopoiesis, aiming to ensure the generation of functionally competent, nonautoimmune repertoire. Secondary Ag receptor gene recombination allows B lymphocytes to replace an inappropriate receptor with a new receptor, a mechanism called receptor editing. This salvage mechanism uncouples the Ag receptor fate from that of the cell itself, suggesting that B cell repertoire is regulated by a process of receptor selection. Secondary rearrangements are stimulated in different stages of B cell development, where editing of the receptor is necessary to fulfill stage-specific requirements. In this study, we discuss the contribution of receptor editing in B lymphopoiesis and its regulation by positive and negative selection signals.
Edry
Efrat
E
Department of Immunology, Faculty of Medicine, Technion, Israel.
Melamed
Doron
D
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology*; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D038041:Lymphopoiesis / Q000235:genetics / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000096:biosynthesis* / Q000502:physiology; D011995:Recombination, Genetic; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology
D011947:Receptors, Antigen, B-Cell