title: Impairments of attention following treatment with cranial irradiation and chemotherapy in children.
abstract: Neurobehavioral impairments are frequently reported following treatment for childhood cancers, with cranial irradiation (CRT). This study investigated attention and information processing skills, predicting that these skills would be impaired due to the vulnerability of cerebral white matter in early childhood. Three treatment groups were studied: (i) CRT+chemotherapy (n = 35); (ii) chemotherapy alone (n = 19); (iii) healthy children (n = 35). All children were aged 9 to 16 years at time of assessment, with no pre-diagnosis history of neurologic, developmental, or psychiatric disorder. Children were administered a series of task measuring processing speed and sustained, selective, and shifting attention. For children treated with CRT + chemo, results identified residual deficits in processing speed for complex tasks, selective and shifting attention. In contrast, processing speed was intact for simple tasks, and there was no clear evidence of deterioration in performance over time, as might be expected in the presence of a sustained attention deficit. Children treated with chemotherapy alone demonstrated generally intact attentional skills. However, this group did record an increasing number of attentional lapses over time on tasks tapping sustained attention skills.
authors.affiliation: Department of Psychology, University of Melbourne, Parkville, Vic. 3052, Australia. v.anderson@psych.unimelb.edu.au
authors.forename: Vicki A
authors.initials: VA
authors.lastname: Anderson
authors.forename: Tim
authors.initials: T
authors.lastname: Godber
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Smibert
authors.forename: Sophie
authors.initials: S
authors.lastname: Weiskop
authors.forename: Henry
authors.initials: H
authors.lastname: Ekert
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects; D016371:Cranial Irradiation / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology; D007361:Intelligence Tests / Q000706:statistics & numerical data; D008297:Male; D009369:Neoplasms / Q000628:therapy; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D013997:Time Factors