CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases.
The gene bla(CARB-9) was located in the Vibrio cholerae super-integron, but in a different location relative to bla(CARB-7). CARB-9 (pI 5.2) conferred beta-lactam MICs four to eight times lower than those conferred by CARB-7, differing at Ambler's positions V97I, L124F, and T228K. Comparison of the genetic environments of all reported bla(CARB) genes indicated that the CARB enzymes constitute a family of cassette-encoded beta-lactamases.
Petroni
Alejandro
A
Servicio Antimicrobianos, INEI-ANLIS "Dr. Carlos G. Malbrán," Av. Velez Sarsfield 563 (1281), Buenos Aires, Argentina.
Melano
Roberto G
RG
Saka
Héctor A
HA
Garutti
Alicia
A
Mange
Laura
L
Pasterán
Fernando
F
Rapoport
Melina
M
Miranda
Mariana
M
Faccone
Diego
D
Rossi
Alicia
A
Hoffman
Paul S
PS
Galas
Marcelo F
MF
D000595:Amino Acid Sequence; D001118:Argentina; D008969:Molecular Sequence Data; D010405:Penicillinase / Q000145:classification / Q000235:genetics*; D020449:Repetitive Sequences, Amino Acid; D014734:Vibrio cholerae / Q000201:enzymology* / Q000235:genetics*; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics* / Q000378:metabolism
D010405:Penicillinase; C493254:CARB-9 beta-lactamases; D001618:beta-Lactamases