Subgroups of irritable bowel syndrome: a new approach.
OBJECTIVE
The newly revised Rome criteria for the definition of irritable bowel syndrome (IBS), derived from the consensus of experts in the field, were developed in order to identify subgroups of IBS patients for research. The criteria have, to our knowledge, never been validated. Both when trying to include IBS patients in studies and in clinical practice we found it difficult to apply the Rome 2 supportive criteria.


OBJECTIVE
To study the variation of stool consistency and defecatory symptoms in IBS patients prospectively with diary cards and to validate the Rome 2 supportive criteria.


METHODS
Sixty IBS patients, included by interview according to the Rome 1 criteria, recorded their bowel symptoms on diary cards over 40 days. Four subgroups were found, characterised by loose-stool-predominant, hard-stool-predominant, alternating stool consistency, and loose stools only. Urgency, straining and feeling of incomplete evacuation occurred in all but seven individuals, irrespective of subgroup.


RESULTS
The Rome 2 criteria could subclassify seven patients into diarrhoea-predominant IBS based on stool consistency and absence of straining and could subclassify no patients into constipation-predominant IBS, as urge was present in nearly all patients. Fifty-three patients could not be classified according to the Rome 2 criteria, as they had defecatory symptoms of all kinds.


CONCLUSIONS
As the Rome 2 supportive criteria use the presence or absence of specific defecatory symptoms as an instrument for categorising IBS patients into diarrhoea- and constipation-predominant subgroups, these criteria could not be used for the majority of IBS patients in this study and should be reconsidered.
Walter
Susanna A
SA
Department of Gastroenterology, University Hospital of Linköping, Sweden. suswa@imk.liu.se
Skagerström
Eva
E
Bodemar
Göran
G
D003248:Constipation / Q000209:etiology; D003967:Diarrhea / Q000209:etiology; D005243:Feces; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000145:classification* / Q000150:complications / Q000523:psychology; D008297:Male; D008499:Medical Records; D011446:Prospective Studies; D018709:Statistics, Nonparametric