Serum leptin concentrations in patients with severe ovarian hyperstimulation syndrome during in vitro fertilization-embryo transfer treatment.
OBJECTIVE
To investigate the changes in serum leptin concentration in the conception cycle of severe ovarian hyperstimulation syndrome (OHSS).


METHODS
Prospective longitudinal study of 66 IVF-ET cycles between May 2000 and June 2002.


METHODS
Infertility outpatient clinic at a Japanese medical school.


METHODS
Infertile patients undergoing IVF-ET cycles at the infertility outpatient clinic were divided into three groups consisting of group 1 (conception-cycle patients with severe OHSS, n = 9), and group 2 (conception cycle, non-OHSS, n = 28), and group 3 (nonconception cycle, non-OHSS, n = 29).


METHODS
Blood samples were collected at five different periods. Period I, on the first day of ovarian stimulation with FSH; period II, at hCG administration before oocyte retrieval; period III, 7 days after oocyte retrieval; period IV, 14 days after oocyte retrieval; and period V, 21 days after oocyte retrieval.


METHODS
Serum leptin concentration.


RESULTS
The serum leptin concentration was low in the OHSS group compared with that of the non-OHSS groups in all serum samples, with significant levels at periods III (vs. groups 2 and 3; P<.05) and IV (vs. group 3; P<.01). A twofold increase of leptin concentration from period I to period II (P<.05) was observed in all groups.


CONCLUSIONS
The change pattern in serum leptin concentration might provide a great contribution to the pathophysiology development of OHSS patients during assisted reproductive treatment.
Ayustawati
Department of Obstetrics and Gynecology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi 329-0498, Japan.
Shibahara
Hiroaki
H
Hirano
Yuki
Y
Suzuki
Tatsuya
T
Takamizawa
Satoru
S
Suzuki
Mitsuaki
M
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D020738:Leptin / Q000097:blood*; D008137:Longitudinal Studies; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood* / Q000503:physiopathology
D020738:Leptin