title: Age-dependent alteration of neural visual adaptation.
abstract: Age alterations of neural visual adaptation mechanisms were studied in young, adult and old rats by means of electroretinogram (ERG) registration. The age peculiarities of neural/fast adaptation appear mostly in limit states, partly in the range of low intensity light stimuli about the threshold sensitivity, partly in the range of high intensity light stimuli. In the case of low intensity light stimuli, the increase of light sensitivity in the course of neural dark adaptation was fastest and greatest in adult animals. In the retina of aged animals, no neural adaptation light sensitivity change could be detected about the ERG threshold. In the domain of medium intensity the adaptability of the aged retina is equivalent to that of young and adult ones, whereas its spatial and temporal summation ability gets worse in this domain. High intensity light stimuli rapidly narrow down the functional range of fast neural adaptation mechanism of the aged animal. Receptor cells of aged animals proved to be most vulnerable to glaring illumination and light loading.
authors.affiliation: Gerontology Center and Second Eye Clinic, Semmelweis University Medical School, P.O. Box 45, H-1428, Budapest, Hungary.
authors.forename: S
authors.initials: S
authors.lastname: Tóth
authors.forename: J
authors.initials: J
authors.lastname: Sármány
authors.forename: V
authors.initials: V
authors.lastname: Kelemen