title: Defects in the prostaglandin system--what is known?
abstract: The central role of prostaglandins as local mediators is well accepted. Molecular biology and in particular knock-out mice models teach us a lot on mechanisms and eventual biological consequences. Despite the broad basic knowledge available, human data on defects in the prostaglandin system are extremely rare. Why? Don't we search for them? Are they of clinical relevance? What is their prevalence, the outcome? How to treat, if possible? For this purpose we are planning a platform and databank to improve knowledge, pool information and allow exchange of probes. All interested people are invited to join.
authors.affiliation: Department of Clinical Pharmacology, University of Vienna, Austria.
authors.forename: Rosemarie A
authors.initials: RA
authors.lastname: Reiter
authors.forename: Bernhard A
authors.initials: BA
authors.lastname: Peskar
authors.forename: Helmut
authors.initials: H
authors.lastname: Sinzinger
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001792:Blood Platelets; D011464:Epoprostenol; D006470:Hemorrhage; D006801:Humans; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D011453:Prostaglandins / Q000235:genetics / Q000502:physiology*; D013927:Thrombosis; D013930:Thromboxane-A Synthase
chemical_list: D011453:Prostaglandins; D016718:Arachidonic Acid; D011464:Epoprostenol; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D013930:Thromboxane-A Synthase