title: Parosteal osteosarcoma of the mastoid bone following radiotherapy for nasopharyngeal carcinoma.
abstract: Radiation-induced tumors subsequent to nasopharyngeal carcinoma are very rare. To date, no post-irradiation parosteal osteosarcoma of the craniofacial bone has been reported in the English literature. In October 2000, a 57-year-old Chinese woman presented 5 years after radiotherapy for nasopharyngeal carcinoma with a 6-month history of a gradually enlarging left postauricular mass. CT scans revealed a densely calcified mass with radiating bony spicules, applied to left mastoid tip. The lesion was excised en-bloc through a postauricular incision. The histologic diagnosis was a parosteal osteosarcoma. Because of inadequate safe margins and the patient refusal of another surgery, 6600 cGy of radiation was subsequently administered to the temporal bone. Post-operative follow-up in 3 years was negative for any evidence of tumor recurrence and post-irradiation complications.
authors.affiliation: Department of Otolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Shun-Ta
authors.initials: ST
authors.lastname: Hsieh
authors.forename: Yuan-Ching
authors.initials: YC
authors.lastname: Guo
authors.forename: Tung-Lung
authors.initials: TL
authors.lastname: Tsai
authors.forename: Win-Yin
authors.initials: WY
authors.lastname: Li
authors.forename: Ching-Zong
authors.initials: CZ
authors.lastname: Lin
mesh_terms: D005260:Female; D006801:Humans; D008416:Mastoid / Q000473:pathology / Q000528:radiation effects*; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging; D012516:Osteosarcoma / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome