title: Palladium(0)-catalyzed cyclization of electron-deficient enynes and enediynes.
abstract: In the presence of a Pd(0) precatalyst, Pd2(bq)2(nbe)2 or Pd2(dba)3, 1,6-enyne esters were heated in refluxing benzene to give cyclodimers as single regioisomers. On the other hand, the combination of the Pd(0) precatalyst and triphenyl phosphite gave rise to various cycloisomerization products depending on the substitution pattern of the enyne esters. Six-membered ring cycloisomerization products were predominantly obtained from enyne esters bearing methallyl or 2-phenyl-2-propenyl moieties, while other enyne esters afforded normal five-membered ring cycloisomerization products. Intramolecular [2 + 2 + 2] cyclocotrimerization of enediyne esters also proceeded in the presence of the Pd(0) precatalyst and triphenylphosphine to give fused cyclohexadienes.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan. yamamoto@apchem.nagoya-u.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Kuwabara
authors.forename: Yoji
authors.initials: Y
authors.lastname: Ando
authors.forename: Hitomi
authors.initials: H
authors.lastname: Nagata
authors.forename: Hisao
authors.initials: H
authors.lastname: Nishiyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Itoh