Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice.
We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.
Nakasone
Chikara
C
Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Kawakami
Kazuyoshi
K
Hoshino
Tomoaki
T
Kawase
Yusuke
Y
Yokota
Koichi
K
Yoshino
Kohichiro
K
Takeda
Kiyoshi
K
Akira
Shizuo
S
Saito
Atsushi
A
D000818:Animals; D054426:Chemokine CXCL2; D017353:Gene Deletion; D020382:Interleukin-18 / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D015846:Monokines / Q000096:biosynthesis / Q000276:immunology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D011552:Pseudomonas Infections / Q000276:immunology* / Q000378:metabolism / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000276:immunology
D054426:Chemokine CXCL2; D020382:Interleukin-18; D015846:Monokines; D014409:Tumor Necrosis Factor-alpha