Apolipoprotein(a) isoforms in infarcted men under 60 years old.
OBJECTIVE
The aim of this study was to compare the Lp(a) concentration and the frequency distribution of the apo(a) isoforms of a myocardial infarcted male group under 60 years old and a group of healthy subjects (controls).


METHODS
A total of 111 infarcted men and 99 men free from disease were enrolled in this study. Lp(a) concentrations were measured by a commercial available rate nephelometry method, and apolipoprotein(a) isoform analysis was performed by sodium dodecyl sulfate (SDS) polyacrilamide gel electrophoresis (PAGE) and immunoblotting.


RESULTS
Infarcted patients had higher Lp(a) concentrations (0.33 +/- 0.36 g/l) than noninfarcted subjects did (0.19 +/- 0.22 g/l), and these differences were significant (P = 0.001). Infarcted patients have also shown a greater proportion of elevated (> or = 0.30 g/l) Lp(a) concentrations 37.8% than controls 20.2% (P < 0.01). The distributions of apo(a) phenotypes for patients with myocardial infarction and controls were remarkably different (P < 0.001), and the proportions of smaller isoforms were significantly different by chi-square analysis (P < 0.01).


CONCLUSIONS
Infarcted patients under 60 years old display higher Lp(a) concentrations and a significantly higher proportion of low molecular weight apolipoprotein(a) isoforms than controls.
Calmarza
Pilar
P
Hospital General Yagüe., Avda. del Cid no. 96, 09005 Burgos, Spain. calmarza@hgy.es
Cordero
José
J
Santos
Victoria
V
Vella
Juan Carlos
JC
D001054:Apolipoproteins A / Q000032:analysis* / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009203:Myocardial Infarction / Q000097:blood*; D010641:Phenotype; D020033:Protein Isoforms
D001054:Apolipoproteins A; D020033:Protein Isoforms