[Study of the strength of compacts of mixed dry binders consisting of powdered cellulose and directly compressible lactose].
The paper studied the strength of compacts of dry binders consisting of powdered cellulose and directly compressible lactose. The powdered cellulose employed was Arbocel A300, the directly compressible lactose, Pharmatosa DCL 21. The first step of the evaluation comprised the tensile strength of compacts and sensitivity of dry binders alone to an addition of magnesium stearate. The same method of evaluation was then used for mixed dry binders from Arbocel A300 and Pharmatosa DCL 21 in ratios of 3:1, 1:1 and 1:3. The tested concentrations of magnesium stearate were 0.4 and 0.8%. Sensitivity of dry binders to an addition of the lubricant was evaluated by means of lubricant sensitivity ratio (LSR) values. The compacts with the highest strength and at the same time the lowest sensitivity to an addition of magnesium stearate were produced using a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3. The evaluation also included the commercially produced mixed dry binder Cellactosa 80, in which higher sensitivity to an addition of stearate than in a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3 was found.
Muzíková
J
J
Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. muzikova@faf.cuni.cz
Hájková
P
P
Vinklarová
S
S
D002482:Cellulose; D007785:Lactose; D010592:Pharmaceutic Aids; D011208:Powders; D013607:Tablets; D013678:Technology, Pharmaceutical; D013718:Tensile Strength
D010592:Pharmaceutic Aids; D011208:Powders; D013607:Tablets; D002482:Cellulose; D007785:Lactose
Studium pevnosti výlisků ze smesných suchých pojiv slozených z práskové celulosy a prímo lisovatelné laktosy.