title: [Syphilis--diagnosis, treatment and characteristics in HIV-infected patients].
abstract: Venereal syphilis is a chronic cyclic infectious disease that, if untreated, runs a decades-long course. The responsible pathogen is Treponema pallidum. Clinically, a differentiation is made into early (primary) syphilis (up to 1 year following infection, syphilis I), during which disease manifestations are localized, secondary syphilis (syphilis II) with generalized manifestations, and late, or tertiary syphilis (syphilis III). Clinical manifestations that have been observed in HIV patients are syphilis maligna and neurosyphilis. Treatment of choice continues to be penicillin. Instead of only a single injection of penicillin, HIV infected patients with early syphilis should be given three injections, with an interval of 1 week between them, to prevent the development of neurosyphilis.
authors.affiliation: Universitätsklinikum Heidelberg. martin.hartmann@uni-heidelberg.de
authors.forename: M
authors.initials: M
authors.lastname: Hartmann
authors.forename: D
authors.initials: D
authors.lastname: Gey
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009494:Neurosyphilis / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D010406:Penicillins / Q000627:therapeutic use*; D011379:Prognosis; D013587:Syphilis / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D019380:Anti-HIV Agents; D010406:Penicillins
vernacular_title: Syphilis und HIV-Infektion. Dem Duo möglichst fruh den Kampf ansagen.