title: Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis.
abstract: Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found significant elevation of tTG concentration in the cerebrospinal fluid (CSF) of 54 patients with Parkinson's disease (PD) compared with that measured in 34 control subjects, thus showing increased neural cell apoptosis in patients with PD.
authors.affiliation: Department of Clinical Chemistry, Medisch Spectrum Twente Hospital Group, Enschede, The Netherlands. i.vermes@ziekenhuis-mst.nl
authors.forename: Istvan
authors.initials: I
authors.lastname: Vermes
authors.forename: Ernst N H Jansen
authors.initials: EN
authors.lastname: Steur
authors.forename: Gustav F
authors.initials: GF
authors.lastname: Jirikowski
authors.forename: Clemens
authors.initials: C
authors.lastname: Haanen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications; D017209:Apoptosis / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000150:complications / Q000503:physiopathology*; D011503:Transglutaminases / Q000134:cerebrospinal fluid*
chemical_list: D011503:Transglutaminases