Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related Kaposi's sarcoma patients before and after diagnosis.
Human herpesvirus 8 (HHV-8) is detected more often in patients progressing towards Kaposi's sarcoma (KS) than in patients who do not develop the disease, suggesting that the level of viremia might be associated with Kaposi's sarcoma disease and progression. Longitudinal serum samples from 19 AIDS-Kaposi's sarcoma patients, ranging from 2 years before KS till 2 years after KS diagnosis were tested. No correlation was found between viral load and progression to KS, or disease stage.
Polstra
Abeltje M
AM
Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands.
Cornelissen
Marion
M
Goudsmit
Jaap
J
van der Kuyl
Antoinette C
AC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D015497:HIV-1; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000821:virology*
D004279:DNA, Viral