An Approach towards the quantitative structure-activity relationships of caffeic acid and its derivatives.
Caffeic acid and its derivatives are already known to possess a wide range of biological activities. We have developed quantitative structure-activity relationships (QSARs) for different series of caffeic acid derivatives (including caffeic acid) in order to understand the chemical-biological interactions governing antitumor activity against six different tumor cell lines, nitric oxide production, anti-HIV and enzymatic activities, and binding affinity to the lck domain. QSAR results have shown that the different activities of caffeic acid and its derivatives are largely dependent on their hydrophobicity or molar refractivity, with a bilinear correlation being the most important.
Verma
Rajeshwar P
RP
Department of Chemistry, Pomona College, Claremont, CA 91711, USA. rverma@pomona.edu
Hansch
Corwin
C
D000465:Algorithms; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D021281:Quantitative Structure-Activity Relationship; D011955:Receptors, Drug / Q000737:chemistry; D018909:src Homology Domains / Q000187:drug effects
D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D002109:Caffeic Acids; D004791:Enzyme Inhibitors; D008024:Ligands; D016859:Lipoxygenase Inhibitors; D011955:Receptors, Drug; D019001:Nitric Oxide Synthase