title: CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases.
abstract: The gene bla(CARB-9) was located in the Vibrio cholerae super-integron, but in a different location relative to bla(CARB-7). CARB-9 (pI 5.2) conferred beta-lactam MICs four to eight times lower than those conferred by CARB-7, differing at Ambler's positions V97I, L124F, and T228K. Comparison of the genetic environments of all reported bla(CARB) genes indicated that the CARB enzymes constitute a family of cassette-encoded beta-lactamases.
authors.affiliation: Servicio Antimicrobianos, INEI-ANLIS "Dr. Carlos G. Malbrán," Av. Velez Sarsfield 563 (1281), Buenos Aires, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Petroni
authors.forename: Roberto G
authors.initials: RG
authors.lastname: Melano
authors.forename: Héctor A
authors.initials: HA
authors.lastname: Saka
authors.forename: Alicia
authors.initials: A
authors.lastname: Garutti
authors.forename: Laura
authors.initials: L
authors.lastname: Mange
authors.forename: Fernando
authors.initials: F
authors.lastname: Pasterán
authors.forename: Melina
authors.initials: M
authors.lastname: Rapoport
authors.forename: Mariana
authors.initials: M
authors.lastname: Miranda
authors.forename: Diego
authors.initials: D
authors.lastname: Faccone
authors.forename: Alicia
authors.initials: A
authors.lastname: Rossi
authors.forename: Paul S
authors.initials: PS
authors.lastname: Hoffman
authors.forename: Marcelo F
authors.initials: MF
authors.lastname: Galas
mesh_terms: D000595:Amino Acid Sequence; D001118:Argentina; D008969:Molecular Sequence Data; D010405:Penicillinase / Q000145:classification / Q000235:genetics*; D020449:Repetitive Sequences, Amino Acid; D014734:Vibrio cholerae / Q000201:enzymology* / Q000235:genetics*; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics* / Q000378:metabolism
chemical_list: D010405:Penicillinase; C493254:CARB-9 beta-lactamases; D001618:beta-Lactamases