title: Does functional mitral regurgitation improve with isolated aortic valve replacement?
abstract: BACKGROUND
  The surgical treatment of mitral valve regurgitation (MR) at the time of aortic valve replacement (AVR) remains controversial. The purpose of this study was to evaluate the change in severity of MR following isolated AVR, and to determine survival benefit.
  
  
  METHODS
  Between 1991 and 2001, 250 patients underwent isolated AVR; 196 patients had concomitant functional MR. Follow-up transthoracic echocardiography (TTE) was available on 107 patients, with a median of 818 +/- 752 days. Aortic valve was stenotic in 77 and regurgitant in 30 patients.
  
  
  RESULTS
  Mean age was 67 +/- 15 years and 57 (53%) were male. Preoperative MR was trivial (1+) in 27 (25%), mild (2+) in 44 (41%), moderate (3+) in 29 (27%), and severe (4+) in 7 (7%). At follow-up TTE, MR improved by 1 or 2 grades in 48 patients (45%). Of patients with preoperative 2+ MR, 19 (43%) improved, 16 (36%) remained unchanged, and 9 (21%) worsened. Although some patients with preoperative 3+ MR exhibited improvement, 11 (38%) remained with moderate-to-severe MR. Of those with a preoperative MR of 4+, 3 (71%) improved, and 4 remained with 3-4+ MR. For patients with preoperative 1 to 2+ MR, survival at 3 years was 98% compared to 78% for those with 3 to 4+ MR (p = 0.038).
  
  
  CONCLUSIONS
  Functional MR does not always improve after isolated AVR. Survival is lower for patients with preoperative 3 to 4+ MR. Moderate-to-severe MR should be repaired at the time of aortic valve surgery.
authors.affiliation: Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA. Moazamin@msnotes.wustl.edu
authors.forename: Nader
authors.initials: N
authors.lastname: Moazami
authors.forename: Michael D
authors.initials: MD
authors.lastname: Diodato
authors.forename: Marc R
authors.initials: MR
authors.lastname: Moon
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Lawton
authors.forename: Michael K
authors.initials: MK
authors.lastname: Pasque
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Herren
authors.forename: Tracey J
authors.initials: TJ
authors.lastname: Guthrie
authors.forename: Ralph J
authors.initials: RJ
authors.lastname: Damiano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000601:surgery*; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000150:complications*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis