title: Cytotoxic constituents of roots of Chaerophyllum hirsutum.
abstract: Two new lignan derivatives (1 and 2), along with the known scopoletin (3), methyl caffeate (4), falcarindiol (5), 3,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic methyl ester, chlorogenic acid, p-hydroxyphenylethyl-trans-ferulate, and vanillin, were isolated from extracts of the roots of Chaerophyllum hirsutum. Structure elucidation of the new compounds was carried out by 1D and 2D NMR experiments and by HRMS analysis. Several of the isolated compounds were tested for their cytotoxic activity against the HL-60, HT-1080, LoVo, and LoVo/Doxo cell lines.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Padova, Via Marzolo 5, 35131 Padova, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Dall'Acqua
authors.forename: Giampietro
authors.initials: G
authors.lastname: Viola
authors.forename: Sonia
authors.initials: S
authors.lastname: Piacente
authors.forename: Elsa Mariella
authors.initials: EM
authors.lastname: Cappelletti
authors.forename: Gabbriella
authors.initials: G
authors.lastname: Innocenti
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007558:Italy; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012603:Scopoletin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C493135:2-(4-hydroxybenzeoyl)-3-(1-(4-hydroxyphenyl)methylidene)succinic acid; C493133:2-(4-hydroxyphenyl)-4-(1-(4-hydroxyphenyl)methylidene)-5-oxotetrahydro-3-furancarboxylic acid; D000972:Antineoplastic Agents, Phytogenic; D001547:Benzaldehydes; D002109:Caffeic Acids; D017705:Lignans; C042405:methyl caffeate; C100058:vanillin; D012603:Scopoletin