[Spironolactone inhibits production of proinflammatory cytokines, including tumor necrosis factor-alpha and interferon-gamma and has potential effect in the treatment of arthritis].
Bendtzen
Klaus
K
H:S Rigshospitalet, Finsencentret, Institut for Inflammationsforskning, og Amtssygehuset i Gentofte, Kardiologisk Afdeling P, København. kben@mail.dk
Hansen
Peter Riis
PR
Rieneck
Klaus
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy* / Q000276:immunology; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D013148:Spironolactone / Q000009:adverse effects / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology
D018501:Antirheumatic Agents; D016207:Cytokines; D000451:Mineralocorticoid Receptor Antagonists; D014409:Tumor Necrosis Factor-alpha; D013148:Spironolactone; D007371:Interferon-gamma
Spironolacton haemmer produktionen af inflammatoriske cytokiner, inklusive tumornekrotiserende faktor-alpha og interferon-gamma og har potentiel effekt ved behandling af artrit.