title: ["Using model organisms and phylogenetic conservation, the DrosoMan project combines high tech hand-made science and industrial know-how to target the Achilles heel of cancer cells. A comparative proteomic project that associates Academia and Biotech"].
abstract: The post-genomic era offers a huge challenge for scientists used to hand-made tailored approaches that can deal with deep insight into a small number of objects. Reciprocally, industry is used to undergo massively parallel approaches, dealing with large numbers but rather shallow insight. The complementation is obviously tantalizing, and Institut Curie and Hybrigenics (HGX) have signed an alliance in the field of cancer and signal transduction. A comparative proteomic approach was undertaken, where ortholog baits from Homo sapiens and flies were used to screen extremely complex two-hybrid cDNA libraries. New partners of "old" proteins have been identified, new networks have emerged, and unexpected connectors have been shown to link biological niches supposed to be independent.
authors.affiliation: Inserm U528, Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05. jcamonis@curie.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Camonis
authors.forename: Laurent
authors.initials: L
authors.lastname: Daviet
mesh_terms: D000818:Animals; D016045:Human Genome Project; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
vernacular_title: "Entre systèmes modèles et conservation phylogénique, le projet DrosoMan de protéomique comparative entre l'Homme et la Drosophile ou l'association de moyens industriels et de la science artisanale pour établir les maillons faibles des ensembles protéiques"