title: Cytotoxic activity of compounds from the lichen: Cladonia convoluta.
abstract: The depsidone 9'-( O-methyl)protocetraric acid was isolated from the lichen Cladonia convoluta (Lam.) Anders along with the known (-)-usnic acid and fumarprotocetraric acid. The complete structure of 9'-( O-methyl)protocetraric acid was elucidated using HSQC and HMBC spectral data. (-)-Usnic acid was the only compound to display a moderate cytotoxic activity on various cancer cell lines (IC (50) = 6, 12.1, 15.8, 17.8, 8.2 and 6.8 microg/mL on L1210, 3LL, DU145, MCF7, K-562 and U251, respectively). This compound was also shown to induce apoptosis of murine leukaemia L1210 cells in a dose- and time-dependent manner.
authors.forename: Carine
authors.initials: C
authors.lastname: Bézivin
authors.forename: Sophie
authors.initials: S
authors.lastname: Tomasi
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rouaud
authors.forename: Jean-Guy
authors.initials: JG
authors.lastname: Delcros
authors.forename: Joël
authors.initials: J
authors.lastname: Boustie
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001203:Ascomycota; D045744:Cell Line, Tumor / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D008011:Lichens; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts