Differential effects of interferon-alpha and -beta on the secretion of vascular endothelial growth factor by eutopic and ectopic endometrial stromal cells.
Interferon (IFN)-beta, not IFN-alpha, suppresses vascular endothelial growth factor secretion in endometriotic cyst stromal cells. It was suggested that IFN-beta may be more suitable than IFN-alpha as an anti-endometriotic agent.
Fukuda
Junichiro
J
Department of Obstetrics and Gynecology, Oita University, Hasama-machi, Oita 879-5593, Japan. dajun1@med.oita-u.ac.jp
Kawano
Yasushi
Y
Nasu
Kaei
K
Nishida
Masakazu
M
Narahara
Hisashi
H
Miyakawa
Isao
I
D002828:Choristoma / Q000473:pathology*; D004717:Endometrium; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D016899:Interferon-beta / Q000494:pharmacology*; D017154:Stromal Cells / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D016898:Interferon-alpha; D042461:Vascular Endothelial Growth Factor A; D016899:Interferon-beta