Chronic inflammatory demyelinating polyradiculoneuropathy in patients with liver transplantation.
We report two patients with orthotopic liver transplantation (OLT) who developed a syndrome that fulfilled criteria for definite chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). One patient had OLT because of alcoholic cirrhosis and one following hepatitis C-induced hepatic failure. Both had immunosuppressive therapy, with cyclosporine and prednisolone in one case and tacrolimus in the other case. Treatment with intravenous immune globulin (IVIG) significantly improved the neuropathy in both patients. In patients with OLT developing disabling sensorimotor neuropathies, CIDP should be considered as should the use of potentially beneficial immunosuppressive treatment.
Echaniz-Laguna
Andoni
A
Département de Neurologie, Hôpital Civil de Strasbourg, 1 Place de l'Hôpital, BP 426, 67091, France. Echaniz-Laguna@medecine.u-strasbg.fr
Battaglia
Fabrice
F
Ellero
Bernard
B
Mohr
Michel
M
Jaeck
Daniel
D
D004568:Electrodiagnosis; D004576:Electromyography; D006526:Hepatitis C / Q000601:surgery; D006801:Humans; D007116:Immunization, Passive; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009460:Neurologic Examination; D010543:Peroneal Nerve / Q000473:pathology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000209:etiology* / Q000473:pathology / Q000628:therapy