title: Homology-based modelling of targets for rational drug design.
abstract: The current status in rational drug design using homology-based models is discussed, with focus on template selection, model building, model verification and strategies for drug design based on model structures. A novel approach for identification of unique binding site features from homology-based models, Protein Alpha Shape Similarity Analysis (PASSA) is described.
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, MTFS, Norwegian University of Science and Technology, N-7489 Trondheim.
authors.forename: Heather
authors.initials: H
authors.lastname: Wieman
authors.forename: Kristin
authors.initials: K
authors.lastname: Tøndel
authors.forename: Endre
authors.initials: E
authors.lastname: Anderssen
authors.forename: Finn
authors.initials: F
authors.lastname: Drabløs
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D017385:Sequence Homology; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D011506:Proteins