title: Alcohol consumption and the risk of bladder cancer in the Framingham Heart Study.
abstract: The association between alcohol consumption and bladder cancer is controversial. We used data from 10,125 participants in the Framingham Heart Study to assess the association between total and beverage-specific alcohol consumption and the risk of bladder cancer. For each case of bladder cancer, up to five control subjects were selected and matched on major confounders using a risk set method. We used conditional logistic regression to assess the risk of bladder cancer according to categories of alcohol consumption. During a mean follow-up of 27.3 +/- 10.1 years, there were 126 incident cases of bladder cancer. There was no statistically significant association between alcohol consumption and risk of bladder cancer (P(trend) =.3). In beverage-specific analyses, beer consumption was associated with a reduced risk of bladder cancer (P(trend) =.03), whereas wine (P(trend) =.7) and spirit (P(trend) =.2) consumption were not. Our data suggest that total and beverage-specific alcohol consumption are not associated with an increased risk of bladder cancer.
authors.affiliation: Preventive Medicine and Epidemiology Section, Evans Department of Medicine, Boston University School of Medicine, Rm. B-612, 715 Albany St., Boston, MA 02118, USA. ldjousse@bu.edu
authors.forename: Luc
authors.initials: L
authors.lastname: Djoussé
authors.forename: Arthur
authors.initials: A
authors.lastname: Schatzkin
authors.forename: Lori B
authors.initials: LB
authors.lastname: Chibnik
authors.forename: Ralph B
authors.initials: RB
authors.lastname: D'Agostino
authors.forename: Bernard E
authors.initials: BE
authors.lastname: Kreger
authors.forename: R Curtis
authors.initials: RC
authors.lastname: Ellison
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000209:etiology*