Detection and expression of Epstein-Barr Virus (EBV) DNA in tissues from penile tumors in Brazil.
Epstein-Barr Virus (EBV) is prevalent in all human populations and high titers of antibody correlate with specific malignancies such as Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease. Our study detected EBV DNA in 20 of 21 penile tumor samples using PCR reaction. Expression of EBV protein LMP-1 was identified in tumor cells from two EBV PCR-positive tumors. Our findings indicate that EBV can be implicated in rising and/or progression of penile tumors independently of the histological type.
Alves
Gilda
G
Serviço de Hematologia, HC I, Instituto Nacional de Câncer, Pç. da Cruz Vermelha, 23, 8 andar, 20230-130 Rio de Janeiro, RJ, Brazil. gbrown@inca.gov.br
Macrini
Camila Menezes Trindade
CM
de Souza Nascimento
Patrícia
P
Morais
José Carlos
JC
Ornellas
Antonio Augusto
AA
D001938:Brazil / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000378:metabolism / Q000821:virology; D018289:Carcinoma, Verrucous / Q000453:epidemiology / Q000378:metabolism / Q000821:virology; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism*; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D010412:Penile Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D016133:Polymerase Chain Reaction; D014763:Viral Matrix Proteins / Q000235:genetics / Q000378:metabolism
D004279:DNA, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins