title: 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.
abstract: 5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.
authors.affiliation: Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. sulskyr@bms.com
authors.forename: Richard
authors.initials: R
authors.lastname: Sulsky
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Robl
authors.forename: Scott A
authors.initials: SA
authors.lastname: Biller
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Harrity
authors.forename: John
authors.initials: J
authors.lastname: Wetterau
authors.forename: Fergal
authors.initials: F
authors.lastname: Connolly
authors.forename: Kern
authors.initials: K
authors.lastname: Jolibois
authors.forename: Lori
authors.initials: L
authors.lastname: Kunselman
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D006224:Cricetinae; D003498:Cyclic P-Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; C473731:BMS201038; D001562:Benzimidazoles; D002352:Carrier Proteins; D003498:Cyclic P-Oxides; C106092:microsomal triglyceride transfer protein