[Immunity of peritoneal monocytes against Plasmodium yoelii infected erythrocytes].
OBJECTIVE
To test the immunity of peritoneal monocytes against Plasmodium yoelii infected red blood cells (target cells).


METHODS
Saponinized Plasmodium yoelii infected red blood cells (SPRBC, Ghost erythrocyte) were used to immunize mice i.p twice. Three weeks later, the infected red blood cells were injected i.p.; 90 min later, the total peritoneal cells were isolated and washed for scanning electromicroscopy to observe the effects of the peritoneal monocyte to the target cell.


RESULTS
The peritoneal cells of the immunized mice were activated after 90 min of the challenge of target cells. The size of the cell was not even and the pili on the cell surface turned to be long and densed. Cell interconnections were found among the cells. In some peritoneal monocytes, their cell plasma were scattered (omlette-like) or with the shape as "cellular bomb". The scattered or the sheeted pili and spredding cell plasma could adhere to the target cells which were perforated densely and damaged.


CONCLUSIONS
The protective adaptive immunity exists in the peritoneal monocytes of immunized mice.
Mao
Ying-hong
YH
Department of Etiology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
Yuan
Jie
J
Liu
Bao-feng
BF
D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D004910:Erythrocyte Membrane / Q000469:parasitology*; D005260:Female; D017780:Malaria Vaccines / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000276:immunology* / Q000648:ultrastructure; D010537:Peritoneum / Q000166:cytology; D010967:Plasmodium yoelii / Q000276:immunology* / Q000648:ultrastructure
D000913:Antibodies, Protozoan; D017780:Malaria Vaccines