title: [The expression of MMP-9, MMP-2 in the remodeling bone tissue around implant during unloaded period].
abstract: OBJECTIVE
  To discuss the function of MMP-9, MMP-2 in the remodeling bone tissue around implant during unloaded period.
  
  
  METHODS
  At the anterior of the maxilla and mandibular of the Beagle dog, implants were placed at different periods, so the implant specimens of different periods were obtained after dogs were killed. The implant specimens were removed, fixed in 4% paraformaldehyde for 24 hours at 4 degrees C, decalcified with 10% EDTA at pH 7.2, embedded in paraffin wax and sectioned. The observation of the expression changes of the MMP-2, MMP-9 in the milien bone tissue of the implant at different periods were taken by immunohistochemical staining.
  
  
  RESULTS
  Matrix metalloprotainase (MMP-9) was mostly expressed at the peripheral cytoplasmic of osteoclast, macrophage, lining cell and fibroblast. MMP-2 was mostly expressed at the peripheral cytoplasmic of osteoblast, fibroblast, some osteoclast also expressed this enzyme.
  
  
  CONCLUSIONS
  MMP-2 and MMP -9 have an important function at the injured bone absorption, healing and bone remodeling after dental implant placement.
authors.affiliation: Dept. of Prosthodontics, the Affiliated Stomatologic Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310006, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Fu-ming
authors.initials: FM
authors.lastname: He
authors.forename: Le-le
authors.initials: LL
authors.lastname: Li
authors.forename: Ji-an
authors.initials: JA
authors.lastname: Hu
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D008334:Mandible; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008437:Maxilla
chemical_list: D015921:Dental Implants; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9