title: Neural control of hepatic osmolytes and parenchymal cell hydration.
abstract: Liver cell function is strongly influenced by cell hydration and osmolyte content via osmosensing and osmosignaling pathways. Electrical stimulation of hepatic nerves increases the hepatocellular hydration state via an alpha-adrenergic mechanism, promotes taurine release from parenchymal cells and myo-inositol release from hepatic stellate cells. Although changes in liver cell hydration and osmolyte content are known regulators of liver cell function, the functional relevance and integration of nerve-stimulation-dependent alterations of liver cell volume and osmolyte content in the overall hepatic response to towards signals from the nervous system remains to be established.
authors.affiliation: Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Düsseldorf, Germany. haeussin@uni-duesseldorf.de
authors.forename: Dieter
authors.initials: D
authors.lastname: Häussinger
mesh_terms: D000818:Animals; D001622:Betaine / Q000378:metabolism; D004558:Electric Stimulation; D022781:Hepatocytes / Q000378:metabolism / Q000502:physiology; D007294:Inositol / Q000378:metabolism; D039641:Integrin beta Chains; D007477:Ions / Q000378:metabolism; D008099:Liver / Q000166:cytology* / Q000294:innervation* / Q000502:physiology; D010525:Peripheral Nerves / Q000502:physiology*; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D013654:Taurine / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D039641:Integrin beta Chains; D007477:Ions; D013654:Taurine; D001622:Betaine; D007294:Inositol