JNKing Revealed.
In a recent issue of Molecular Cell, Sabapathy et al. (2004) demonstrate that JNK2 destabilizes c-Jun under nonstimulating conditions, whereas after stress, activated JNK1 phosphorylates c-Jun, resulting in its activation and stabilization, thereby highlighting functional differences between JNK1 and JNK2.
Ronai
Ze'ev
Z
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.
D000818:Animals; D002478:Cells, Cultured; D004789:Enzyme Activation; D005347:Fibroblasts / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D048055:Mitogen-Activated Protein Kinase 8; D048056:Mitogen-Activated Protein Kinase 9; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008954:Models, Biological; D010766:Phosphorylation; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D013379:Substrate Specificity
D016755:Proto-Oncogene Proteins c-jun; D048056:Mitogen-Activated Protein Kinase 9; D048055:Mitogen-Activated Protein Kinase 8; D020928:Mitogen-Activated Protein Kinases