title: Usefulness of the peak velocity difference by tissue Doppler imaging technique as an effective predictor of response to cardiac resynchronization therapy.
abstract: Cardiac resynchronization therapy (CRT) improves symptoms and functional status in heart failure patients; however, current selection criteria need improvement. A novel tissue Doppler imaging parameter, the peak velocity difference (PVD), defined as the greatest difference in time to peak velocity between any of 6 left ventricular regions, may better select responders to CRT. Subjects were divided into 2 groups based on the PVD. Clinical and echocardiographic parameters significantly improved in subjects with dyssynchrony by the baseline PVD and had a better overall response to CRT.
authors.affiliation: Division of Cardiology, The Carlyle Fraser Heart Center, Emory University School of Medicine, 550 Peachtree Street NE, Atlanta, GA 30308, USA.
authors.forename: Dean
authors.initials: D
authors.lastname: Notabartolo
authors.forename: John D
authors.initials: JD
authors.lastname: Merlino
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Smith
authors.forename: David B
authors.initials: DB
authors.lastname: DeLurgio
authors.forename: Fernando V
authors.initials: FV
authors.lastname: Vera
authors.forename: Kirk A
authors.initials: KA
authors.lastname: Easley
authors.forename: Randolph P
authors.initials: RP
authors.lastname: Martin
authors.forename: Angel R
authors.initials: AR
authors.lastname: León
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial; D016009:Chi-Square Distribution; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008297:Male; D018579:Patient Selection; D011237:Predictive Value of Tests; D018709:Statistics, Nonparametric