Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men.
The human androgen receptor (AR) gene contains a CAG (glutamine) repeat polymorphism in exon 1 that is inversely associated with transcriptional activity of the AR. We studied the association of AR CAG repeat length, fat-free mass (FFM), and testosterone in two independent cohorts: 294 Caucasian men, aged 55-93 yr, from the Study of Osteoporotic Risk in Men (STORM), and 202 Caucasian volunteers (112 men and 90 women), aged 19-90 yr, from the Baltimore Longitudinal Study of Aging (BLSA). Subjects were genotyped to determine the number of AR CAG repeats and grouped as carrying either < 22 or > or =22 repeats. Whole body soft tissue composition was measured by dual-energy X-ray absorptiometry. Men with greater CAG repeat number exhibited significantly greater total FFM than those with fewer CAG repeats in both cohorts (STORM: 59.2 +/- 0.3 vs. 58.0 +/- 0.4 kg, P = 0.02; BLSA: 57.2 +/- 1.1 vs. 53.8 +/- 1.1 kg, P = 0.04). Similar results were observed for total FFM normalized to height. No differences were seen in women in the BLSA cohort. In the BLSA cohort, serum testosterone levels were higher in subjects with greater repeat number (P = 0.003). This same pattern approached significance in the STORM cohort (P = 0.07). In conclusion, the androgen receptor CAG repeat polymorphism is associated with FFM in men in two independent cohorts. Additional studies are needed to confirm this observation and to clarify the mechanisms involved.
Walsh
Sean
S
Dept. of Kinesiology, University of Maryland, 2134 HHP Bldg., College Park, MD 20742-2611, USA.
Zmuda
Joseph M
JM
Cauley
Jane A
JA
Shea
Patrick R
PR
Metter
E Jeffrey
EJ
Hurley
Ben F
BF
Ferrell
Robert E
RE
Roth
Stephen M
SM
D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000502:physiology; D000328:Adult; D000368:Aged; D001823:Body Composition / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005973:Glutamine / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009929:Organ Size / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011944:Receptors, Androgen / Q000235:genetics*; D013223:Statistics as Topic; D013739:Testosterone / Q000097:blood*; D018911:Trinucleotide Repeats / Q000235:genetics*
D011944:Receptors, Androgen; D005973:Glutamine; D013739:Testosterone