Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma.
GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.
Sensi
Elisa
E
Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and University Hospital of Pisa, Italy.
Tancredi
Mariella
M
Aretini
Paolo
P
Cipollini
Giovanna
G
Collecchi
Paola
P
Naccarato
A Giuseppe
AG
Viacava
Paolo
P
Bevilacqua
Generoso
G
Caligo
Maria A
MA
D001943:Breast Neoplasms / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics*; D004249:DNA Damage; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D019656:Loss of Heterozygosity; D010375:Pedigree; D011506:Proteins / Q000235:genetics*; D000097642:GADD45 Proteins
D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D000097642:GADD45 Proteins