HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY.
Yannopoulos
Constantin G
CG
ViroChem Pharma Inc., 275 Armand-Frappier Blvd., Laval, Quebec, Canada H7V 4A7. cyannopoulos@virochempharma.com
Xu
Ping
P
Ni
Feng
F
Chan
Laval
L
Pereira
Oswy Z
OZ
Reddy
T Jagadeeswar
TJ
Das
Sanjoy K
SK
Poisson
Carl
C
Nguyen-Ba
Nghe
N
Turcotte
Nathalie
N
Proulx
Melanie
M
Halab
Lilianne
L
Wang
Wuyi
W
Bédard
Jean
J
Morin
Nicolas
N
Hamel
Martine
M
Nicolas
Olivier
O
Bilimoria
Darius
D
L'Heureux
Lucille
L
Bethell
Richard
R
Dionne
Gervais
G
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry
D000998:Antiviral Agents; D011725:Pyridines; D013449:Sulfonamides; D013876:Thiophenes; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase