True versus mild hyperthermia during isolated hepatic perfusion: effects on melphalan pharmacokinetics and liver function.
Pilati
Pierluigi
P
Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Mocellin
Simone
S
Rossi
Carlo R
CR
Ori
Carlo
C
Innocente
Federico
F
Scalerta
Romano
R
Ceccherini
Mauro
M
Da Pian
Pier Paolo
PP
Nitti
Donato
D
Lise
Mario
M
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000493:pharmacokinetics* / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000473:pathology; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D004195:Disease Models, Animal; D004357:Drug Synergism; D005240:Feasibility Studies; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D006979:Hyperthermia, Induced / Q000379:methods*; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D008558:Melphalan / Q000493:pharmacokinetics* / Q000633:toxicity; D011877:Radionuclide Imaging; D013552:Swine; D013668:Technetium Tc 99m Aggregated Albumin / Q000493:pharmacokinetics; D013696:Temperature
D018906:Antineoplastic Agents, Alkylating; D013668:Technetium Tc 99m Aggregated Albumin; D008558:Melphalan