In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.
Sutinen
J
J
Division of Diabetes, Department of Medicine, University of Helsinki, Helsinki, Finland. jussi.sutinen@hus.fi
Kannisto
K
K
Korsheninnikova
E
E
Nyman
T
T
Ehrenborg
E
E
Andrew
R
R
Wake
D J
DJ
Hamsten
A
A
Walker
B R
BR
Yki-Järvinen
H
H
D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000235:genetics*; D000273:Adipose Tissue / Q000201:enzymology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008060:Lipodystrophy / Q000139:chemically induced*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D006854:Hydrocortisone