Human herpesvirus 6 DNA polymerase: enzymatic parameters, sensitivity to ganciclovir and determination of the role of the A961V mutation in HHV-6 ganciclovir resistance.
De Bolle
Leen
L
Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.
Manichanh
Chaysavanh
C
Agut
Henri
H
De Clercq
Erik
E
Naesens
Lieve
L
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism*; D024882:Drug Resistance, Viral / Q000235:genetics; D015774:Ganciclovir / Q000494:pharmacology*; D005814:Genes, Viral; D015654:Herpesvirus 6, Human / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D016297:Mutagenesis, Site-Directed; D019384:Nucleic Acid Synthesis Inhibitors; D017354:Point Mutation; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D011817:Rabbits
D000998:Antiviral Agents; D019384:Nucleic Acid Synthesis Inhibitors; D012333:RNA, Messenger; D012367:RNA, Viral; D004259:DNA-Directed DNA Polymerase; D015774:Ganciclovir