Proteoglycan depletion of intact articular cartilage by retinoic acid is irreversible and involves loss of hyaluronate.
Von den Hoff
H W
HW
Jan van Breemen Instituut, Center for Rheumatology and Rehabilitation, Amsterdam, The Netherlands.
van Kampen
G P
GP
van der Korst
J K
JK
D053674:Aggrecans; D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism*; D002417:Cattle; D002847:Chromatography, Agarose; D004305:Dose-Response Relationship, Drug; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis; D006820:Hyaluronic Acid / Q000378:metabolism*; D037181:Lectins, C-Type; D011509:Proteoglycans / Q000096:biosynthesis / Q000378:metabolism*; D046509:Tissue Culture Techniques; D014212:Tretinoin / Q000494:pharmacology*
D053674:Aggrecans; D016326:Extracellular Matrix Proteins; D037181:Lectins, C-Type; D011509:Proteoglycans; D014212:Tretinoin; D006820:Hyaluronic Acid