Crystal structures of HbA2 and HbE and modeling of hemoglobin delta 4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb.
Sen
Udayaditya
U
Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064, India.
Dasgupta
Jhimli
J
Choudhury
Debi
D
Datta
Poppy
P
Chakrabarti
Abhijit
A
Chakrabarty
Sudipa Basu
SB
Chakrabarty
Amit
A
Dattagupta
Jiban K
JK
D017398:Alternative Splicing / Q000235:genetics; D000986:Antisickling Agents / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D003460:Crystallization; D018360:Crystallography, X-Ray; D005295:Ferrocyanides / Q000378:metabolism*; D018698:Glutamic Acid / Q000235:genetics; D006443:Hemoglobin A2 / Q000737:chemistry* / Q000378:metabolism; D006446:Hemoglobin E / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008239:Lysine / Q000235:genetics; D008706:Methemoglobin / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D009154:Mutation; D011489:Protein Denaturation; D011499:Protein Processing, Post-Translational; D021122:Protein Subunits / Q000737:chemistry* / Q000378:metabolism; D013816:Thermodynamics
D000986:Antisickling Agents; D005295:Ferrocyanides; D006454:Hemoglobins; D021122:Protein Subunits; C007169:cyanomethemoglobin; D018698:Glutamic Acid; D008706:Methemoglobin; D006443:Hemoglobin A2; D006446:Hemoglobin E; C020354:hexacyanoferrate II; D008239:Lysine