title: Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant.
authors.affiliation: CV/CNS Biological Research and Discovery Technologies, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Randolph
authors.forename: J S
authors.initials: JS
authors.lastname: Simon
authors.forename: M G
authors.initials: MG
authors.lastname: Arreaza
authors.forename: P
authors.initials: P
authors.lastname: Qiu
authors.forename: J E
authors.initials: JE
authors.lastname: Lachowicz
authors.forename: R A
authors.initials: RA
authors.lastname: Duffy
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000187:drug effects / Q000235:genetics*; D006639:Histidine / Q000235:genetics; D006801:Humans; D064729:Neurokinin-1 Receptor Antagonists; D010446:Peptide Fragments / Q000494:pharmacology; D020641:Polymorphism, Single Nucleotide / Q000187:drug effects / Q000235:genetics*; D011485:Protein Binding / Q000187:drug effects / Q000235:genetics; D018040:Receptors, Neurokinin-1 / Q000819:agonists / Q000235:genetics*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D014443:Tyrosine / Q000235:genetics
chemical_list: D064729:Neurokinin-1 Receptor Antagonists; D010446:Peptide Fragments; D018040:Receptors, Neurokinin-1; C068032:GR 73632; D013373:Substance P; D014443:Tyrosine; D006639:Histidine