title: Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.
authors.affiliation: Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C. Valeria, Gazzi, 98100 Messina, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Genovese
authors.forename: Emanuela
authors.initials: E
authors.lastname: Mazzon
authors.forename: Carmelo
authors.initials: C
authors.lastname: Muià
authors.forename: Nimesh S A
authors.initials: NS
authors.lastname: Patel
authors.forename: Michael D
authors.initials: MD
authors.lastname: Threadgill
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
authors.forename: Angelina
authors.initials: A
authors.lastname: De Sarro
authors.forename: Christoph
authors.initials: C
authors.lastname: Thiemermann
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cuzzocrea
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001549:Benzamides / Q000494:pharmacology / Q000627:therapeutic use; D015153:Blotting, Western; D002467:Cell Nucleus / Q000187:drug effects / Q000201:enzymology; D003720:Densitometry; D024202:Electrophoretic Mobility Shift Assay; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D020672:I-kappa B Proteins / Q000378:metabolism; D020287:In Situ Nick-End Labeling; D007546:Isoquinolines / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000473:pathology*
chemical_list: C411425:5-aminoisoquinolinone; D001549:Benzamides; D004791:Enzyme Inhibitors; D020672:I-kappa B Proteins; D007546:Isoquinolines; D016328:NF-kappa B; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C025160:3-aminobenzamide; D009195:Peroxidase; D011065:Poly(ADP-ribose) Polymerases