Enhanced hepatocyte-selective in vivo gene expression by stabilized galactosylated liposome/plasmid DNA complex using sodium chloride for complex formation.
Fumoto
Shintaro
S
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Kawakami
Shigeru
S
Ito
Yoshitaka
Y
Shigeta
Kosuke
K
Yamashita
Fumiyoshi
F
Hashida
Mitsuru
M
D000818:Animals; D002460:Cell Line; D004247:DNA / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D005260:Female; D031541:Fluorescence Resonance Energy Transfer; D005690:Galactose / Q000737:chemistry*; D015870:Gene Expression; D022781:Hepatocytes / Q000378:metabolism*; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008156:Luciferases / Q000032:analysis / Q000235:genetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010477:Perfusion; D010957:Plasmids / Q000008:administration & dosage* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000737:chemistry*; D014162:Transfection / Q000379:methods*
D008081:Liposomes; D012965:Sodium Chloride; D004247:DNA; D008156:Luciferases; D005690:Galactose