Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4+CD25+ regulatory T cells to rescue abortion-prone fetuses.
Zhu
Xiao-Yong
XY
Laboratory of Reproductive Immunology, Institute of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China.
Zhou
Yue-Hua
YH
Wang
Ming-Yan
MY
Jin
Li-Ping
LP
Yuan
Min-Min
MM
Li
Da-Jin
DJ
D000022:Abortion, Spontaneous / Q000503:physiopathology*; D000818:Animals; D019138:Antibodies, Blocking / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D015703:Antigens, CD / Q000502:physiology; D051940:B7-2 Antigen; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism; D003656:Decidua / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005327:Fetal Resorption / Q000503:physiopathology; D005434:Flow Cytometry; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010920:Placenta / Q000502:physiology; D011247:Pregnancy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D015375:Receptors, Interleukin-2 / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018417:Th1 Cells / Q000378:metabolism / Q000502:physiology; D018418:Th2 Cells / Q000502:physiology*
D019138:Antibodies, Blocking; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D051940:B7-2 Antigen; C497965:Cd86 protein, mouse; D016207:Cytokines; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D015375:Receptors, Interleukin-2