Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2'-5' oligoadenylate synthetase.
Goswami
Biswendu B
BB
Division of Molecular Biology, Office of Applied Research and Safety Assessment, Food and Drug Administration, HFS-025, OARSA, FDA, 8301 Muirkirk Road, Laurel, MD 20708, USA, bgoswami@cfsan.fda.gov
Kulka
Michael
M
Ngo
Diana
D
Cebula
Thomas A
TA
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D004789:Enzyme Activation; D000882:Haplorhini; D030041:Hepatitis A virus / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology*; D016899:Interferon-beta / Q000494:pharmacology*; D012335:RNA, Ribosomal / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000227:Adenine Nucleotides; D012335:RNA, Ribosomal; D016899:Interferon-beta; D015088:2',5'-Oligoadenylate Synthetase; D020169:Caspases