A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection.
Olcott
Angelica P
AP
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1735, USA.
Tocco
Georges
G
Tian
Jide
J
Zekzer
Dan
D
Fukuto
Jon
J
Ignarro
Louis
L
Kaufman
Daniel L
DL
D000818:Animals; D002384:Catalysis; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control*; D005029:Ethylenediamines / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006084:Graft Rejection / Q000517:prevention & control*; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D017895:Manganese Compounds / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D016688:Mice, Inbred NOD; D009942:Organometallic Compounds / Q000494:pharmacology*
D005029:Ethylenediamines; D016166:Free Radical Scavengers; D017895:Manganese Compounds; D009942:Organometallic Compounds; C090577:N,N'-bis(salicylideneamino)ethane-manganese(II)