title: Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.
authors.affiliation: Prometheus Laboratories, San Diego, California, USA.
authors.forename: Thierry
authors.initials: T
authors.lastname: Dervieux
authors.forename: Daniel
authors.initials: D
authors.lastname: Furst
authors.forename: Diana Orentas
authors.initials: DO
authors.lastname: Lein
authors.forename: Robert
authors.initials: R
authors.lastname: Capps
authors.forename: Katie
authors.initials: K
authors.lastname: Smith
authors.forename: Michael
authors.initials: M
authors.lastname: Walsh
authors.forename: Joel
authors.initials: J
authors.lastname: Kremer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018501:Antirheumatic Agents / Q000378:metabolism / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics; D003430:Cross-Sectional Studies; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D019877:Hydroxymethyl and Formyl Transferases / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics*; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use*; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000235:genetics; D009709:Nucleotide Deaminases / Q000235:genetics; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D058978:Reduced Folate Carrier Protein; D013940:Thymidylate Synthase / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D002352:Carrier Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009097:Multienzyme Complexes; D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human; C120043:SLC19A2 protein, human; C113120:inosine monophosphate synthase; D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D013940:Thymidylate Synthase; D019877:Hydroxymethyl and Formyl Transferases; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase; D009709:Nucleotide Deaminases; D008727:Methotrexate