Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin K.
Tavares
Francis X
FX
Department of Medicinal Chemistry, Discovery Research Biology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. francis.x.tavares@gsk.com
Deaton
David N
DN
Miller
Aaron B
AB
Miller
Larry R
LR
Wright
Lois L
LL
Zhou
Hui-Qiang
HQ
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry; D056657:Cathepsin K; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
D000577:Amides; D002219:Carbamates; D003503:Cyclobutanes; D003517:Cyclopentanes; D007659:Ketones; D011720:Pyrazoles; D002403:Cathepsins; D056657:Cathepsin K