title: Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0359, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Copp
authors.forename: Sandra
authors.initials: S
authors.lastname: Wiley
authors.forename: Manus W
authors.initials: MW
authors.lastname: Ward
authors.forename: Peter
authors.initials: P
authors.lastname: van der Geer
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D053148:Caspase 3; D020169:Caspases / Q000187:drug effects / Q000378:metabolism*; D002522:Chlorocebus aethiops; D045304:Cytochromes c / Q000187:drug effects / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology; D015151:Immunoblotting; D047468:Immunoprecipitation; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D020928:Mitogen-Activated Protein Kinases / Q000187:drug effects / Q000378:metabolism; D009997:Osmotic Pressure / Q000187:drug effects; D017978:Receptors, Growth Factor / Q000378:metabolism*; D012462:Saline Solution, Hypertonic; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014709:Vero Cells; D018631:ras Proteins / Q000187:drug effects / Q000378:metabolism
chemical_list: D006133:Growth Substances; D017978:Receptors, Growth Factor; D012462:Saline Solution, Hypertonic; D045304:Cytochromes c; D020928:Mitogen-Activated Protein Kinases; D053148:Caspase 3; D020169:Caspases; D018631:ras Proteins