title: PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.
authors.affiliation: Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Deangelo
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Kutok
authors.forename: Ifor R
authors.initials: IR
authors.lastname: Williams
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Lee
authors.forename: Martha
authors.initials: M
authors.lastname: Wadleigh
authors.forename: Nicole
authors.initials: N
authors.lastname: Duclos
authors.forename: Sarah
authors.initials: S
authors.lastname: Cohen
authors.forename: Jennifer
authors.initials: J
authors.lastname: Adelsperger
authors.forename: Rachel
authors.initials: R
authors.lastname: Okabe
authors.forename: Allison
authors.initials: A
authors.lastname: Coburn
authors.forename: Ilene
authors.initials: I
authors.lastname: Galinsky
authors.forename: Brian
authors.initials: B
authors.lastname: Huntly
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Cohen
authors.forename: Thomas
authors.initials: T
authors.lastname: Meyer
authors.forename: Doriano
authors.initials: D
authors.lastname: Fabbro
authors.forename: Johannes
authors.initials: J
authors.lastname: Roesel
authors.forename: Lolita
authors.initials: L
authors.lastname: Banerji
authors.forename: James D
authors.initials: JD
authors.lastname: Griffin
authors.forename: Sheng
authors.initials: S
authors.lastname: Xiao
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fletcher
authors.forename: Richard M
authors.initials: RM
authors.lastname: Stone
authors.forename: D Gary
authors.initials: DG
authors.lastname: Gilliland
mesh_terms: D000818:Animals; D002460:Cell Line; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D004195:Disease Models, Animal; D005260:Female; D014644:Genetic Variation; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D051496:Receptor, Fibroblast Growth Factor, Type 1; D017468:Receptors, Fibroblast Growth Factor / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014170:Transformation, Genetic; D014178:Translocation, Genetic; D016335:Zinc Fingers
chemical_list: D017468:Receptors, Fibroblast Growth Factor; C496348:FGFR1 protein, human; C496349:Fgfr1 protein, mouse; D020794:Receptor Protein-Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1; D019311:Staurosporine; C059539:midostaurin