Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.
Mor
Marco
M
Dipartimento Farmaceutico, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43100 Parma, Italy.
Rivara
Silvia
S
Lodola
Alessio
A
Plazzi
Pier Vincenzo
PV
Tarzia
Giorgio
G
Duranti
Andrea
A
Tontini
Andrea
A
Piersanti
Giovanni
G
Kathuria
Satish
S
Piomelli
Daniele
D
D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003510:Cyclohexanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship; D051381:Rats; D012044:Regression Analysis; D000099252:Fatty Acid Amide Hydrolases
D000581:Amidohydrolases; D002219:Carbamates; D003510:Cyclohexanes; D000099252:Fatty Acid Amide Hydrolases