Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
Chockalingam
Priya S
PS
Wyeth Research, Cambridge, Massachusetts 02140, USA.
Zeng
Weilan
W
Morris
Elisabeth A
EA
Flannery
Carl R
CR
D051722:ADAM Proteins; D000071121:ADAMTS4 Protein; D053674:Aggrecans; D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism*; D002417:Cattle; D016207:Cytokines / Q000494:pharmacology; D010450:Endopeptidases / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism*; D007375:Interleukin-1 / Q000494:pharmacology; D037181:Lectins, C-Type; D008666:Metalloendopeptidases / Q000494:pharmacology*; D011348:Procollagen N-Endopeptidase; D011509:Proteoglycans / Q000378:metabolism*; D000099249:Proteoglycan Link Protein
D051722:ADAM Proteins; D000071121:ADAMTS4 Protein; D053674:Aggrecans; D016207:Cytokines; D010450:Endopeptidases; D016326:Extracellular Matrix Proteins; D006025:Glycosaminoglycans; D006820:Hyaluronic Acid; D007375:Interleukin-1; D037181:Lectins, C-Type; D008666:Metalloendopeptidases; D011348:Procollagen N-Endopeptidase; D011509:Proteoglycans; D000099249:Proteoglycan Link Protein; C013786:A73025; C000603918:ADAMTS4 protein, human; C083641:aggrecanase