Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.
Sechi
Mario
M
Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy. mario.sechi@uniss.it
Derudas
Massimiliano
M
Dallocchio
Roberto
R
Dessì
Alessandro
A
Bacchi
Alessia
A
Sannia
Luciano
L
Carta
Fabrizio
F
Palomba
Michele
M
Ragab
Omar
O
Chan
Carney
C
Shoemaker
Robert
R
Sei
Shizuko
S
Dayam
Raveendra
R
Neamati
Nouri
N
D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D015195:Drug Design; D019427:HIV Integrase / Q000737:chemistry / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007651:Keto Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D012996:Solutions; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000821:virology
D019428:HIV Integrase Inhibitors; D007211:Indoles; D007651:Keto Acids; D012996:Solutions; D019427:HIV Integrase