Lead (Pb(+2)) impairs long-term memory and blocks learning-induced increases in hippocampal protein kinase C activity.
Vázquez
Adrinel
A
Department of Biology, University of Puerto Rico, San Juan 00931-3360, Puerto Rico.
Peña de Ortiz
Sandra
S
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005508:Food Deprivation; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006185:Habituation, Psychophysiologic; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology*; D007150:Immunohistochemistry; D007854:Lead / Q000633:toxicity*; D007858:Learning / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced* / Q000523:psychology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D020318:Rats, Long-Evans
D007854:Lead; D011493:Protein Kinase C; D002118:Calcium