Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats.
Saxena
Geetu
G
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India.
Flora
S J S
SJ
D000818:Animals; D001921:Brain / Q000187:drug effects; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000627:therapeutic use; D005978:Glutathione / Q000097:blood; D006454:Hemoglobins / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D007854:Lead / Q000378:metabolism; D007855:Lead Poisoning / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D008670:Metals / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D000623:Porphobilinogen Synthase / Q000097:blood; D011524:Protoporphyrins / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D004113:Succimer / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014494:Unithiol / Q000627:therapeutic use
D002614:Chelating Agents; D006454:Hemoglobins; D008670:Metals; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007854:Lead; D014494:Unithiol; D004492:Edetic Acid; C091888:monoisoamyl-2,3-dimercaptosuccinate; D004113:Succimer; D000623:Porphobilinogen Synthase; D005978:Glutathione