Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives.
Imai
Minoru
M
Teijin Institute for Bio-medical Research, 4-3-2 Asahigaoka, Hino, Tokyo 191-8512, Japan. min.imai@teijin.co.jp
Shiota
Tatsuki
T
Kataoka
Ken-ichiro
K
Tarby
Christine M
CM
Moree
Wilna J
WJ
Tsutsumi
Takaharu
T
Sudo
Masaki
M
Ramirez-Weinhouse
Michele M
MM
Comer
Daniel
D
Sun
Chung-Ming
CM
Yamagami
Shinsuke
S
Tanaka
Hiroko
H
Morita
Takuya
T
Hada
Takahiko
T
Greene
Jonathan
J
Barnum
Doug
D
Saunders
John
J
Myers
Peter L
PL
Kato
Yoshinori
Y
Endo
Noriaki
N
D002460:Cell Line; D018932:Chemokine CCL2 / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D006801:Humans; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
C515334:CCR2 protein, human; D018932:Chemokine CCL2; D010879:Piperazines; D054390:Receptors, CCR2; D019707:Receptors, Chemokine