title: A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats.
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Cui
authors.forename: Zeng-Lu
authors.initials: ZL
authors.lastname: Xu
authors.forename: Zhan-Jun
authors.initials: ZJ
authors.lastname: Yang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Xu
authors.forename: She-Pu
authors.initials: SP
authors.lastname: Xue
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D020169:Caspases / Q000235:genetics; D003272:Contraceptive Agents, Male / Q000008:administration & dosage* / Q000009:adverse effects; D053938:DNA Fragmentation; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D006072:Gossypol / Q000008:administration & dosage* / Q000009:adverse effects; D017403:In Situ Hybridization; D020287:In Situ Nick-End Labeling; D008297:Male; D008777:Methyltestosterone / Q000008:administration & dosage*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D051028:bcl-2-Associated X Protein; D019014:fas Receptor / Q000235:genetics
chemical_list: C494828:Bax protein, rat; D003272:Contraceptive Agents, Male; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D051028:bcl-2-Associated X Protein; D019014:fas Receptor; D004997:Ethinyl Estradiol; D020169:Caspases; D006072:Gossypol; D008777:Methyltestosterone