The development of a modified human IFN-alpha2b linked to the Fc portion of human IgG1 as a novel potential therapeutic for the treatment of hepatitis C virus infection.
Jones
Tim D
TD
Biovation Ltd., Babraham, Cambridge, UK. tim.jones@biovation.co.uk
Hanlon
Marian
M
Smith
Beverley J
BJ
Heise
Charles T
CT
Nayee
Prakash D
PD
Sanders
Deborah A
DA
Hamilton
Anita
A
Sweet
Clive
C
Unitt
Esther
E
Alexander
Graeme
G
Lo
Kin-Ming
KM
Gillies
Stephen D
SD
Carr
Frank J
FJ
Baker
Matthew P
MP
D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000737:chemistry* / Q000627:therapeutic use; D002460:Cell Line; D018984:Epitopes, T-Lymphocyte / Q000032:analysis; D016174:Hepacivirus / Q000187:drug effects / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D007128:Immunoglobulin Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000235:genetics* / Q000276:immunology; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000737:chemistry / Q000235:genetics* / Q000627:therapeutic use; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics; D017354:Point Mutation; D011993:Recombinant Fusion Proteins / Q000276:immunology; D011994:Recombinant Proteins
D000998:Antiviral Agents; D018984:Epitopes, T-Lymphocyte; D007141:Immunoglobulin Fc Fragments; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010455:Peptides; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins