Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.
Edsall
Allison B
AB
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Mohanakrishnan
Arasambattu K
AK
Yang
Donglai
D
Fanwick
Philip E
PE
Hamel
Ernest
E
Hanson
Arthur D
AD
Agoston
Gregory E
GE
Cushman
Mark
M
D000077584:2-Methoxyestradiol; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001704:Biopolymers; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry*
D000970:Antineoplastic Agents; D001704:Biopolymers; D014404:Tubulin; D004958:Estradiol; D000077584:2-Methoxyestradiol