Discovery of novel nuclear receptor modulating ligands: an integral role for peptide interaction profiling.
Pearce
Kenneth H
KH
Department of Gene Expression and Protein Biochemistry, GlaxoSmithKline Discovery Research, Research Triangle Park, NC 27709, USA. kenneth.h.pearce@gsk.com
Iannone
Marie A
MA
Simmons
Catherine A
CA
Gray
John G
JG
D000818:Animals; D015195:Drug Design; D008024:Ligands; D015394:Molecular Structure; D009928:Organ Specificity; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry*
D008024:Ligands; D019151:Peptide Library; D010455:Peptides; D018160:Receptors, Cytoplasmic and Nuclear