Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice.
Ito
Yoshiya
Y
Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona, 85724-5044, USA.
Abril
Edward R
ER
Bethea
Nancy W
NW
McCuskey
Robert S
RS
D000082:Acetaminophen / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000473:pathology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D006470:Hemorrhage / Q000201:enzymology / Q000473:pathology; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D008833:Microcirculation / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D009336:Necrosis; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology
C480682:2-((4-biphenylsulfonyl)amino)-3-phenylpropionic acid; D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D013449:Sulfonamides; D000082:Acetaminophen; D010649:Phenylalanine; D020782:Matrix Metalloproteinases; D005978:Glutathione