Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.
Vooijs
Marc
M
Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Schroeter
Eric H
EH
Pan
Yonghua
Y
Blandford
Mary
M
Kopan
Raphael
R
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D053829:Amyloid Precursor Protein Secretases; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000737:chemistry; D001665:Binding Sites; D019921:Biotinylation; D015153:Blotting, Western; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D019281:Dimerization; D010450:Endopeptidases / Q000378:metabolism; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D005822:Genetic Vectors; D006801:Humans; D047468:Immunoprecipitation; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry*; D051379:Mice; D008954:Models, Biological; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009154:Mutation; D041681:NIH 3T3 Cells; D010455:Peptides / Q000737:chemistry; D010957:Plasmids / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D051880:Receptors, Notch; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014162:Transfection
D008024:Ligands; D008565:Membrane Proteins; D010455:Peptides; D051880:Receptors, Notch; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C460085:signal peptide peptidase; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse