title: Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer.
authors.affiliation: Servicio de Análisis Clínicos, Hospital Universitario Virgen de las Nieves, Universidad de Granada, 18014 Granada, Spain.
authors.forename: Jose María
authors.initials: JM
authors.lastname: Romero
authors.forename: Pilar
authors.initials: P
authors.lastname: Jiménez
authors.forename: Teresa
authors.initials: T
authors.lastname: Cabrera
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Cózar
authors.forename: Susana
authors.initials: S
authors.lastname: Pedrinaci
authors.forename: Miguel
authors.initials: M
authors.lastname: Tallada
authors.forename: Federico
authors.initials: F
authors.lastname: Garrido
authors.forename: Francisco
authors.initials: F
authors.lastname: Ruiz-Cabello
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D017951:Antigen Presentation; D017920:Antiporters / Q000378:metabolism; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000378:metabolism; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008285:Major Histocompatibility Complex; D026901:Membrane Transport Proteins; D009097:Multienzyme Complexes / Q000378:metabolism; D009154:Mutation; D046988:Proteasome Endopeptidase Complex; D013602:T-Lymphocytes, Cytotoxic; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000235:genetics / Q000378:metabolism*
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D017920:Antiporters; D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; D026901:Membrane Transport Proteins; D009097:Multienzyme Complexes; C073119:TAP1 protein, human; D001613:beta 2-Microglobulin; C107762:tapasin; C071313:LMP-2 protein; C071692:TAP2 protein, human; D003546:Cysteine Endopeptidases; C077436:LMP7 protein; D046988:Proteasome Endopeptidase Complex