Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
Barten
D M
DM
Neuroscience Drug Discovery, Bristol-Myers Squibb, P.O. Box 5100, 3CD-405, 5 Research Pkwy., Wallingford, CT 06492, USA. donna.barten@bms.com
Guss
V L
VL
Corsa
J A
JA
Loo
A
A
Hansel
S B
SB
Zheng
M
M
Munoz
B
B
Srinivasan
K
K
Wang
B
B
Robertson
B J
BJ
Polson
C T
CT
Wang
J
J
Roberts
S B
SB
Hendrick
J P
JP
Anderson
J J
JJ
Loy
J K
JK
Denton
R
R
Verdoorn
T A
TA
Smith
D W
DW
Felsenstein
K M
KM
D000375:Aging / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D015153:Blotting, Western; D001923:Brain Chemistry / Q000187:drug effects* / Q000235:genetics*; D002469:Cell Separation; D004305:Dose-Response Relationship, Drug; D010450:Endopeptidases / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006801:Humans; D047468:Immunoprecipitation; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D058225:Plaque, Amyloid / Q000473:pathology; D011480:Protease Inhibitors / Q000494:pharmacology*; D051880:Receptors, Notch; D013601:T-Lymphocytes / Q000378:metabolism
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; D011480:Protease Inhibitors; D051880:Receptors, Notch; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse