title: Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
authors.affiliation: Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center (KASPAC), Neurotec, Novum, SE-141 57 Huddinge, Sweden.
authors.forename: Camilla A
authors.initials: CA
authors.lastname: Hansson
authors.forename: Susanne
authors.initials: S
authors.lastname: Frykman
authors.forename: Mark R
authors.initials: MR
authors.lastname: Farmery
authors.forename: Lars O
authors.initials: LO
authors.lastname: Tjernberg
authors.forename: Camilla
authors.initials: C
authors.lastname: Nilsberth
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Pursglove
authors.forename: Akira
authors.initials: A
authors.lastname: Ito
authors.forename: Bengt
authors.initials: B
authors.lastname: Winblad
authors.forename: Richard F
authors.initials: RF
authors.lastname: Cowburn
authors.forename: Johan
authors.initials: J
authors.lastname: Thyberg
authors.forename: Maria
authors.initials: M
authors.lastname: Ankarcrona
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000544:Alzheimer Disease / Q000378:metabolism; D000595:Amino Acid Sequence; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000737:chemistry; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry; D000818:Animals; D017209:Apoptosis; D016282:Aspartic Acid Endopeptidases; D001921:Brain / Q000378:metabolism; D002793:Cholic Acids / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D010450:Endopeptidases / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D015151:Immunoblotting; D047468:Immunoprecipitation; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008565:Membrane Proteins / Q000096:biosynthesis*; D016253:Microscopy, Immunoelectron; D008928:Mitochondria / Q000378:metabolism; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D018384:Oxidative Stress; D010447:Peptide Hydrolases; D010455:Peptides / Q000737:chemistry; D053764:Presenilin-1; D017434:Protein Structure, Tertiary; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D002793:Cholic Acids; D003902:Detergents; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C469349:PSENEN protein, human; D010455:Peptides; D053764:Presenilin-1; C413604:nicastrin protein; C048531:chapso; D000255:Adenosine Triphosphate; C475154:APH1A protein, human; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D010447:Peptide Hydrolases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human