title: Taxol induces caspase-10-dependent apoptosis.
authors.affiliation: Department of Pharmacology and Toxicology and Indiana University Cancer Center, Indianapolis, Indiana 46202, USA.
authors.forename: Soo-Jung
authors.initials: SJ
authors.lastname: Park
authors.forename: Ching-Haung
authors.initials: CH
authors.lastname: Wu
authors.forename: John D
authors.initials: JD
authors.lastname: Gordon
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zhong
authors.forename: Armaghan
authors.initials: A
authors.lastname: Emami
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Safa
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis* / Q000737:chemistry; D017304:Annexin A5 / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D015153:Blotting, Western; D002352:Carrier Proteins / Q000378:metabolism; D053455:Caspase 10; D053148:Caspase 3; D053178:Caspase 6; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000096:biosynthesis* / Q000378:metabolism; D018929:Cell Culture Techniques; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival; D004396:Coloring Agents / Q000494:pharmacology; D045304:Cytochromes c / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D053200:Fas-Associated Death Domain Protein; D005434:Flow Cytometry; D005799:Genes, Dominant; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D008954:Models, Biological; D017239:Paclitaxel / Q000494:pharmacology*; D010957:Plasmids / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D017382:Reactive Oxygen Species; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D014162:Transfection
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D017304:Annexin A5; D000972:Antineoplastic Agents, Phytogenic; D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D004396:Coloring Agents; C412403:DIABLO protein, human; D004791:Enzyme Inhibitors; C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D047888:Receptors, Tumor Necrosis Factor, Type I; D013778:Tetrazolium Salts; D013844:Thiazoles; D045304:Cytochromes c; D011065:Poly(ADP-ribose) Polymerases; C505407:CASP3 protein, human; C505514:CASP6 protein, human; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053455:Caspase 10; D053148:Caspase 3; D053178:Caspase 6; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases; C506438:CASP10 protein, human; C022616:thiazolyl blue; D017239:Paclitaxel