Once-daily propranolol extended-release tablet dosage form: formulation design and in vitro/in vivo investigation.
Huang
Yaw-Bin
YB
School of Pharmacy, Kaohsiung Medical University, Kaohsiung City, Taiwan, ROC.
Tsai
Yi-Hung
YH
Yang
Wan-Chiech
WC
Chang
Jui-Sheng
JS
Wu
Pao-Chu
PC
Takayama
Kozo
K
D000284:Administration, Oral; D000818:Animals; D002482:Cellulose / Q000008:administration & dosage / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D004285:Dogs; D004304:Dosage Forms; D004334:Drug Administration Schedule; D015195:Drug Design; D007785:Lactose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008297:Male; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D010078:Oxazines; D011433:Propranolol / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D013607:Tablets
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D010078:Oxazines; D013607:Tablets; D002482:Cellulose; D008747:Methylcellulose; C071191:MK 458; D011433:Propranolol; D007785:Lactose; C109691:microcrystalline cellulose