Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells.
Ray
Adrian S
AS
Department of Drug Metabolism, Gilead Sciences, Inc., Foster City, CA 94404, USA. aray@gilead.com
Vela
Jennifer E
JE
Olson
Loren
L
Fridland
Arnold
A
D000225:Adenine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D000818:Animals; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D001692:Biological Transport; D002478:Cells, Cultured; D003838:Deoxyadenine Nucleotides / Q000378:metabolism; D006207:Half-Life; D006515:Hepatitis B virus / Q000187:drug effects; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D063065:Organophosphonates / Q000493:pharmacokinetics*; D010766:Phosphorylation
D000998:Antiviral Agents; D003838:Deoxyadenine Nucleotides; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine; C026600:2'-deoxyadenosine triphosphate