title: PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.
authors.affiliation: Burnham Institute, La Jolla, California 92037, USA.
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Bruey
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bruey-Sedano
authors.forename: Ruchi
authors.initials: R
authors.lastname: Newman
authors.forename: Sharon
authors.initials: S
authors.lastname: Chandler
authors.forename: Christian
authors.initials: C
authors.lastname: Stehlik
authors.forename: John C
authors.initials: JC
authors.lastname: Reed
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051017:Apoptosis Regulatory Proteins; D001483:Base Sequence; D001665:Binding Sites; D053468:CARD Signaling Adaptor Proteins; D020170:Caspase 1 / Q000378:metabolism*; D002460:Cell Line; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D004789:Enzyme Activation; D015870:Gene Expression; D006801:Humans; D018836:Inflammation Mediators / Q000737:chemistry / Q000378:metabolism*; D007375:Interleukin-1 / Q000096:biosynthesis; D008264:Macrophages / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics; D014162:Transfection
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D003598:Cytoskeletal Proteins; D018836:Inflammation Mediators; D007375:Interleukin-1; D016328:NF-kappa B; C495732:NLRP2 protein, human; C402202:PYCARD protein, human; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D020170:Caspase 1