Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination.
Antony
Joseph M
JM
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
van Marle
Guido
G
Opii
Wycliffe
W
Butterfield
D Allan
DA
Mallet
François
F
Yong
Voon Wee
VW
Wallace
John L
JL
Deacon
Robert M
RM
Warren
Kenneth
K
Power
Christopher
C
D000328:Adult; D000368:Aged; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001253:Astrocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D016923:Cell Death / Q000276:immunology; D002460:Cell Line; D003373:Coumaric Acids / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004660:Encephalitis / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D020077:Endogenous Retroviruses / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015686:Gene Products, env / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D009186:Myelin Sheath / Q000378:metabolism; D009836:Oligodendroglia / Q000276:immunology* / Q000378:metabolism; D010084:Oxidation-Reduction; D011257:Pregnancy Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000494:pharmacology
D000975:Antioxidants; D003373:Coumaric Acids; D015686:Gene Products, env; D011257:Pregnancy Proteins; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D011993:Recombinant Fusion Proteins; C405335:syncytin; C004999:ferulic acid