title: Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects.
authors.affiliation: Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA. wnuk@fiu.edu
authors.forename: Stanislaw F
authors.initials: SF
authors.lastname: Wnuk
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Lewandowska
authors.forename: Pablo R
authors.initials: PR
authors.lastname: Sacasa
authors.forename: Leigh N
authors.initials: LN
authors.lastname: Crain
authors.forename: Jinsong
authors.initials: J
authors.lastname: Zhang
authors.forename: Ronald T
authors.initials: RT
authors.lastname: Borchardt
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D010920:Placenta / Q000201:enzymology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D043383:Adenosylhomocysteinase; D000241:Adenosine; D014529:Uridine