Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
Beswick
Paul
P
Neurology and Gastrointestinal Diseases, Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.
Bingham
Sharon
S
Bountra
Chas
C
Brown
Terry
T
Browning
Kerry
K
Campbell
Ian
I
Chessell
Iain
I
Clayton
Nick
N
Collins
Sue
S
Corfield
John
J
Guntrip
Stephen
S
Haslam
Claudine
C
Lambeth
Paul
P
Lucas
Fiona
F
Mathews
Neil
N
Murkit
Graham
G
Naylor
Alan
A
Pegg
Neil
N
Pickup
Elizabeth
E
Player
Hazel
H
Price
Helen
H
Stevens
Alexander
A
Stratton
Sharon
S
Wiseman
Joanne
J
D000284:Administration, Oral; D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy; D001682:Biological Availability; D001921:Brain / Q000378:metabolism; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D005620:Freund's Adjuvant; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry* / Q000378:metabolism; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D008565:Membrane Proteins; D011720:Pyrazoles; D011724:Pyridazines; D005620:Freund's Adjuvant; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases