Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.
Van Aubel
Rémon A M H
RA
Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.
Smeets
Pascal H E
PH
van den Heuvel
Jeroen J M W
JJ
Russel
Frans G M
FG
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics; D018929:Cell Culture Techniques; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008099:Liver / Q000502:physiology; D026901:Membrane Transport Proteins / Q000378:metabolism; D008727:Methotrexate / Q000493:pharmacokinetics; D024101:Mitochondrial Proteins / Q000378:metabolism; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D027361:Organic Anion Transporters / Q000378:metabolism; D012269:Ribosomal Proteins / Q000378:metabolism; D018411:Spodoptera; D014527:Uric Acid / Q000493:pharmacokinetics*
D000255:Adenosine Triphosphate; D000964:Antimetabolites, Antineoplastic; D000242:Cyclic AMP; D006152:Cyclic GMP; D026901:Membrane Transport Proteins; D008727:Methotrexate; D024101:Mitochondrial Proteins; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D027361:Organic Anion Transporters; D012269:Ribosomal Proteins; D014527:Uric Acid; C000715087:ABCC2 protein, human; C073492:ABCC4 protein, human; C103862:urate transporter