Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens.
Koopman
Gerrit
G
Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, the Netherlands.
Mortier
Daniella
D
Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, the Netherlands.
Hofman
Sam
S
Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, the Netherlands.
Niphuis
Henk
H
Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, the Netherlands.
Fagrouch
Zahra
Z
Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, the Netherlands.
Norley
Steve
S
Robert Koch Institut, Nordufer 20, D-13353 Berlin, Germany.
Sutter
Gerd
G
GSF-Institut für Molekulare Virologie, Trogerstrasse 4b, 81675 München, Germany.
Liljeström
Peter
P
Karolinska Institute, PO Box 280, SE-171 77 Solna, Sweden.
Heeney
Jonathan L
JL
Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, the Netherlands.
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D018791:CD4 Lymphocyte Count; D007114:Immunization; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008253:Macaca mulatta; D018449:SAIDS Vaccines / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
D000914:Antibodies, Viral; D007376:Interleukin-2; D018449:SAIDS Vaccines; D014614:Vaccines, Synthetic; D015847:Interleukin-4; D007371:Interferon-gamma