Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways.
Weinmann
Martin
M
Department of Radiation Oncology, University of Tübingen, Tübingen, Germany.
Jendrossek
Verena
V
Güner
Dilek
D
Goecke
Barbara
B
Belka
Claus
C
D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D019069:Cell Respiration; D050759:Cyclin-Dependent Kinase Inhibitor p21; D005047:Etoposide / Q000633:toxicity; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008562:Membrane Glycoproteins / Q000633:toxicity; D008928:Mitochondria / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D010507:Periodicity; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry; D011839:Radiation, Ionizing; D015398:Signal Transduction; D053221:TNF-Related Apoptosis-Inducing Ligand; D014157:Transcription Factors / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000633:toxicity; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051028:bcl-2-Associated X Protein
D051017:Apoptosis Regulatory Proteins; C494826:BAX protein, human; C493956:CDKN1A protein, human; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008562:Membrane Glycoproteins; D019253:Proto-Oncogene Proteins c-bcl-2; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014157:Transcription Factors; D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein; D005047:Etoposide