JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats.
Wei
Min
M
Department of Pathology, Osaka City University Medical School, Osaka, Japan.
Morimura
Keiichirou
K
Wanibuchi
Hideki
H
Shen
Jun
J
Salim
Elsayed I
EI
Moku
Masaharu
M
Hakoi
Katsuo
K
Fukushima
Shoji
S
D019813:1,2-Dimethylhydrazine / Q000633:toxicity*; D000230:Adenocarcinoma / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D000236:Adenoma / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control; D000818:Animals; D001557:Benzenesulfonates / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002273:Carcinogens / Q000633:toxicity*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D018450:Disease Progression; D020869:Gene Expression Profiling; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D010080:Oxazoles / Q000627:therapeutic use*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D000096926:Benzenesulfonamides
D019813:1,2-Dimethylhydrazine; D001557:Benzenesulfonates; D014408:Biomarkers, Tumor; D002273:Carcinogens; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D010080:Oxazoles; D011451:Prostaglandin-Endoperoxide Synthases; C110453:4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide; D000096926:Benzenesulfonamides