O6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course.
Watanabe
Takao
T
Department of Neurological Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-kamumachi, Itabashi-ku, Tokyo 173-8610, Japan. takao@med.nihon-u.ac.jp
Katayama
Yoichi
Y
Komine
Chiaki
C
Yoshino
Atsuo
A
Ogino
Akiyoshi
A
Ohta
Takashi
T
Fukushima
Takao
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D001932:Brain Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D019175:DNA Methylation; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016899:Interferon-beta / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D015376:Nimustine / Q000494:pharmacology; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics; D011446:Prospective Studies; D011829:Radiation Dosage; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53; D015376:Nimustine; D016899:Interferon-beta; D019853:O(6)-Methylguanine-DNA Methyltransferase