title: Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity.
authors.affiliation: Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Tim A
authors.initials: TA
authors.lastname: Rand
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Ginalski
authors.forename: Nick V
authors.initials: NV
authors.lastname: Grishin
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D060565:Argonaute Proteins; D002460:Cell Line; D043224:Deoxyribonuclease (Pyrimidine Dimer) / Q000737:chemistry / Q000235:genetics; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics; D034743:RNA-Induced Silencing Complex / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D017386:Sequence Homology, Amino Acid; D012965:Sodium Chloride
chemical_list: C433807:AGO2 protein, Drosophila; D060565:Argonaute Proteins; D029721:Drosophila Proteins; D011506:Proteins; D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex; C116498:piwi protein, Drosophila; D012965:Sodium Chloride; D043224:Deoxyribonuclease (Pyrimidine Dimer)