title: Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
authors.affiliation: Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, CA 92008, USA. aeldrup@isisph.com
authors.forename: Anne B
authors.initials: AB
authors.lastname: Eldrup
authors.forename: Marija
authors.initials: M
authors.lastname: Prhavc
authors.forename: Jennifer
authors.initials: J
authors.lastname: Brooks
authors.forename: Balkrishen
authors.initials: B
authors.lastname: Bhat
authors.forename: Thazha P
authors.initials: TP
authors.lastname: Prakash
authors.forename: Quanlai
authors.initials: Q
authors.lastname: Song
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bera
authors.forename: Neelima
authors.initials: N
authors.lastname: Bhat
authors.forename: Prasad
authors.initials: P
authors.lastname: Dande
authors.forename: P Dan
authors.initials: PD
authors.lastname: Cook
authors.forename: C Frank
authors.initials: CF
authors.lastname: Bennett
authors.forename: Steven S
authors.initials: SS
authors.lastname: Carroll
authors.forename: Richard G
authors.initials: RG
authors.lastname: Ball
authors.forename: Michele
authors.initials: M
authors.lastname: Bosserman
authors.forename: Christine
authors.initials: C
authors.lastname: Burlein
authors.forename: Lawrence F
authors.initials: LF
authors.lastname: Colwell
authors.forename: John F
authors.initials: JF
authors.lastname: Fay
authors.forename: Osvaldo A
authors.initials: OA
authors.lastname: Flores
authors.forename: Krista
authors.initials: K
authors.lastname: Getty
authors.forename: Robert L
authors.initials: RL
authors.lastname: LaFemina
authors.forename: Joseph
authors.initials: J
authors.lastname: Leone
authors.forename: Malcolm
authors.initials: M
authors.lastname: MacCoss
authors.forename: Daniel R
authors.initials: DR
authors.lastname: McMasters
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Tomassini
authors.forename: Derek
authors.initials: D
authors.lastname: Von Langen
authors.forename: Bohdan
authors.initials: B
authors.lastname: Wolanski
authors.forename: David B
authors.initials: DB
authors.lastname: Olsen
mesh_terms: D000243:Adenosine Deaminase / Q000737:chemistry; D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D002460:Cell Line; D004355:Drug Stability; D016174:Hepacivirus / Q000235:genetics*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010766:Phosphorylation; D011683:Purine-Nucleoside Phosphorylase / Q000737:chemistry; D012367:RNA, Viral / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D013329:Structure-Activity Relationship
chemical_list: C492972:4-amino-5-fluoro-7H-pyrrolo(2,3-d)pyrimidine ribonucleoside; D000998:Antiviral Agents; D012367:RNA, Viral; D012263:Ribonucleosides; D011683:Purine-Nucleoside Phosphorylase; D000243:Adenosine Deaminase