title: Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives.
authors.affiliation: Teijin Institute for Bio-medical Research, 4-3-2 Asahigaoka, Hino, Tokyo 191-8512, Japan. min.imai@teijin.co.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Imai
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Shiota
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Kataoka
authors.forename: Christine M
authors.initials: CM
authors.lastname: Tarby
authors.forename: Wilna J
authors.initials: WJ
authors.lastname: Moree
authors.forename: Takaharu
authors.initials: T
authors.lastname: Tsutsumi
authors.forename: Masaki
authors.initials: M
authors.lastname: Sudo
authors.forename: Michele M
authors.initials: MM
authors.lastname: Ramirez-Weinhouse
authors.forename: Daniel
authors.initials: D
authors.lastname: Comer
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Yamagami
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tanaka
authors.forename: Takuya
authors.initials: T
authors.lastname: Morita
authors.forename: Takahiko
authors.initials: T
authors.lastname: Hada
authors.forename: Jonathan
authors.initials: J
authors.lastname: Greene
authors.forename: Doug
authors.initials: D
authors.lastname: Barnum
authors.forename: John
authors.initials: J
authors.lastname: Saunders
authors.forename: Peter L
authors.initials: PL
authors.lastname: Myers
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kato
authors.forename: Noriaki
authors.initials: N
authors.lastname: Endo
mesh_terms: D002460:Cell Line; D018932:Chemokine CCL2 / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D006801:Humans; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: C515334:CCR2 protein, human; D018932:Chemokine CCL2; D010879:Piperazines; D054390:Receptors, CCR2; D019707:Receptors, Chemokine