title: Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
authors.affiliation: Neuroscience Drug Discovery, Bristol-Myers Squibb, P.O. Box 5100, 3CD-405, 5 Research Pkwy., Wallingford, CT 06492, USA. donna.barten@bms.com
authors.forename: D M
authors.initials: DM
authors.lastname: Barten
authors.forename: V L
authors.initials: VL
authors.lastname: Guss
authors.forename: J A
authors.initials: JA
authors.lastname: Corsa
authors.forename: A
authors.initials: A
authors.lastname: Loo
authors.forename: S B
authors.initials: SB
authors.lastname: Hansel
authors.forename: M
authors.initials: M
authors.lastname: Zheng
authors.forename: B
authors.initials: B
authors.lastname: Munoz
authors.forename: K
authors.initials: K
authors.lastname: Srinivasan
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: B J
authors.initials: BJ
authors.lastname: Robertson
authors.forename: C T
authors.initials: CT
authors.lastname: Polson
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: S B
authors.initials: SB
authors.lastname: Roberts
authors.forename: J P
authors.initials: JP
authors.lastname: Hendrick
authors.forename: J J
authors.initials: JJ
authors.lastname: Anderson
authors.forename: J K
authors.initials: JK
authors.lastname: Loy
authors.forename: R
authors.initials: R
authors.lastname: Denton
authors.forename: T A
authors.initials: TA
authors.lastname: Verdoorn
authors.forename: D W
authors.initials: DW
authors.lastname: Smith
authors.forename: K M
authors.initials: KM
authors.lastname: Felsenstein
mesh_terms: D000375:Aging / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D015153:Blotting, Western; D001923:Brain Chemistry / Q000187:drug effects* / Q000235:genetics*; D002469:Cell Separation; D004305:Dose-Response Relationship, Drug; D010450:Endopeptidases / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006801:Humans; D047468:Immunoprecipitation; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D058225:Plaque, Amyloid / Q000473:pathology; D011480:Protease Inhibitors / Q000494:pharmacology*; D051880:Receptors, Notch; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; D011480:Protease Inhibitors; D051880:Receptors, Notch; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse