Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Hays
Thomas
T
Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Rusyn
Ivan
I
Burns
Amanda M
AM
Kennett
Mary J
MJ
Ward
Jerrold M
JM
Gonzalez
Frank J
FJ
Peters
Jeffrey M
JM
D042962:Acyl-CoA Oxidase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001629:Bezafibrate / Q000378:metabolism* / Q000633:toxicity; D001647:Bile Acids and Salts / Q000378:metabolism; D015152:Blotting, Northern; D018797:Cell Cycle Proteins / Q000187:drug effects / Q000378:metabolism; D002779:Cholestasis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D042926:Cytochrome P-450 CYP4A / Q000187:drug effects / Q000378:metabolism; D045643:DNA Repair Enzymes / Q000187:drug effects / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D047493:PPAR alpha / Q000172:deficiency* / Q000235:genetics; D020025:Peroxisome Proliferators / Q000633:toxicity*; D012333:RNA, Messenger / Q000032:analysis; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors / Q000187:drug effects / Q000378:metabolism; D000099150:Receptor, Farnesoid X-Activated
D042962:Acyl-CoA Oxidase; D001629:Bezafibrate; D001647:Bile Acids and Salts; D018797:Cell Cycle Proteins; D042926:Cytochrome P-450 CYP4A; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins; D047493:PPAR alpha; D020025:Peroxisome Proliferators; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated