Polychlorinated biphenyl mixtures (Aroclors) induce apoptosis via Bcl-2, Bax and caspase-3 proteins in neuronal cell cultures.
Sánchez-Alonso
Jesús Adolfo
JA
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Alcalá de Henares, 28871 Madrid, Spain.
López-Aparicio
Pilar
P
Recio
María N
MN
Pérez-Albarsanz
Miguel A
MA
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001140:Aroclors / Q000633:toxicity*; D015153:Blotting, Western; D053148:Caspase 3; D020169:Caspases / Q000502:physiology*; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004249:DNA Damage / Q000187:drug effects; D053938:DNA Fragmentation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000187:drug effects*; D009707:Nucleosomes / Q000187:drug effects; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*; D051381:Rats; D051028:bcl-2-Associated X Protein
D001140:Aroclors; C494828:Bax protein, rat; D004785:Environmental Pollutants; D009707:Nucleosomes; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D007770:L-Lactate Dehydrogenase; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases