Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects.
Wnuk
Stanislaw F
SF
Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA. wnuk@fiu.edu
Lewandowska
Elzbieta
E
Sacasa
Pablo R
PR
Crain
Leigh N
LN
Zhang
Jinsong
J
Borchardt
Ronald T
RT
De Clercq
Erik
E
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D010920:Placenta / Q000201:enzymology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D000480:Alkynes; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D043383:Adenosylhomocysteinase; D000241:Adenosine; D014529:Uridine