Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands.
Ray
Denise M
DM
The Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA.
Bernstein
Steven H
SH
Phipps
Richard P
RP
D017209:Apoptosis; D015153:Blotting, Western; D020169:Caspases / Q000187:drug effects / Q000378:metabolism; D045744:Cell Line, Tumor; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D007155:Immunologic Factors / Q000494:pharmacology*; D020287:In Situ Nick-End Labeling; D015850:Interleukin-6 / Q000378:metabolism; D008024:Ligands; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009101:Multiple Myeloma / Q000276:immunology*; D047495:PPAR gamma / Q000096:biosynthesis* / Q000187:drug effects; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D045162:Thiazolidinediones / Q000494:pharmacology*; D014212:Tretinoin / Q000378:metabolism
C097240:15-deoxy-delta(12,14)-prostaglandin J2; D007155:Immunologic Factors; D015850:Interleukin-6; D008024:Ligands; D047495:PPAR gamma; D012333:RNA, Messenger; D045162:Thiazolidinediones; D014212:Tretinoin; D020169:Caspases; D015230:Prostaglandin D2; C039671:ciglitazone