title: Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine.
authors.affiliation: Department of Biological Sciences, University of Delaware, Delaware Biotechnology Institute, Newark, DE 19711, USA.
authors.forename: Hetal
authors.initials: H
authors.lastname: Parekh-Olmedo
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: James F
authors.initials: JF
authors.lastname: Gusella
authors.forename: Eric B
authors.initials: EB
authors.lastname: Kmiec
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D042622:DNA Repeat Expansion; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism; D002479:Inclusion Bodies; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D016017:Odds Ratio; D009841:Oligonucleotides / Q000235:genetics / Q000378:metabolism*; D016716:PC12 Cells; D010455:Peptides / Q000378:metabolism* / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C499524:Htt protein, rat; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D009841:Oligonucleotides; D010455:Peptides; D011993:Recombinant Fusion Proteins; C097188:polyglutamine