title: Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis.
authors.affiliation: Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nomoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Iigo
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hamada
authors.forename: Shuji
authors.initials: S
authors.lastname: Kojima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D001397:Azoxymethane / Q000633:toxicity; D044946:Biflavonoids / Q000494:pharmacology / Q000627:therapeutic use; D002273:Carcinogens / Q000633:toxicity; D053148:Caspase 3; D020169:Caspases / Q000187:drug effects / Q000378:metabolism*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects*; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D007150:Immunohistochemistry; D008297:Male; D044945:Proanthocyanidins / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000975:Antioxidants; D044946:Biflavonoids; D002273:Carcinogens; D044945:Proanthocyanidins; C013221:proanthocyanidin; C479580:procyanidin B2; D002392:Catechin; C045651:epigallocatechin gallate; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; D001397:Azoxymethane