Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes.
Blanchard
Nadège
N
Pharma Research Basel (70/131), F. Hoffmann-LaRoche Ltd., Pharmaceuticals Division, Grenzacherstrasse No. 124, CH 4070 Basel, Switzerland.
Richert
Lysiane
L
Notter
Brigitte
B
Delobel
Frederic
F
David
Pascale
P
Coassolo
Philippe
P
Lavé
Thierry
T
D000818:Animals; D002478:Cells, Cultured; D002853:Chromatography, Liquid; D003470:Culture Media / Q000737:chemistry*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D022781:Hepatocytes / Q000201:enzymology / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000201:enzymology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011237:Predictive Value of Tests; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar
D003470:Culture Media; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System