title: Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively.
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Lai
authors.forename: Eun-Woo
authors.initials: EW
authors.lastname: Lee
authors.forename: Carl C
authors.initials: CC
authors.lastname: Ton
authors.forename: Shashi
authors.initials: S
authors.lastname: Vijay
authors.forename: Huixia
authors.initials: H
authors.lastname: Zhang
authors.forename: Jashvant D
authors.initials: JD
authors.lastname: Unadkat
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D017124:Conserved Sequence; D004285:Dogs; D005838:Genotype; D049452:Green Fluorescent Proteins / Q000235:genetics; D006151:Guanosine / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000166:cytology; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D014316:Tritium; D014529:Uridine / Q000493:pharmacokinetics
chemical_list: D026901:Membrane Transport Proteins; C065171:cif nucleoside transporter; D014316:Tritium; D006151:Guanosine; D049452:Green Fluorescent Proteins; D014529:Uridine