LEAPT: lectin-directed enzyme-activated prodrug therapy.
Robinson
Mark A
MA
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.
Charlton
Stuart T
ST
Garnier
Philippe
P
Wang
Xiang-tao
XT
Davis
Stanley S
SS
Perkins
Alan C
AC
Frier
Malcolm
M
Duncan
Ruth
R
Savage
Tony J
TJ
Wyatt
David A
DA
Watson
Susan A
SA
Davis
Benjamin G
BG
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics / Q000627:therapeutic use; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D016503:Drug Delivery Systems; D004789:Enzyme Activation; D004795:Enzyme Stability; D006026:Glycoside Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007668:Kidney / Q000378:metabolism; D037102:Lectins; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011355:Prodrugs / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015202:Protein Engineering; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; D037102:Lectins; D011355:Prodrugs; D004317:Doxorubicin; D006026:Glycoside Hydrolases; C022525:alpha-L-rhamnosidase