Mutations in the carboxy-terminus of the third intracellular loop of the human recombinant VPAC1 receptor impair VIP-stimulated [Ca2+]i increase but not adenylate cyclase stimulation.
Langer
Ingrid
I
Department of Biological Chemistry and Nutrition, Faculty of Medicine, Université Libre de Bruxelles, Campus Erasme, Bât G/E, 808 route de Lennik CP611, B-1070 Brussels, Belgium. ilanger@ulb.ac.be
Robberecht
Patrick
P
D000262:Adenylyl Cyclases / Q000187:drug effects / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D016466:CHO Cells; D002118:Calcium / Q000378:metabolism*; D006224:Cricetinae; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010446:Peptide Fragments; D017433:Protein Structure, Secondary; D018005:Receptors, Vasoactive Intestinal Peptide / Q000737:chemistry* / Q000235:genetics*; D051238:Receptors, Vasoactive Intestinal Polypeptide, Type I; D011994:Recombinant Proteins / Q000737:chemistry; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D010446:Peptide Fragments; D018005:Receptors, Vasoactive Intestinal Peptide; D051238:Receptors, Vasoactive Intestinal Polypeptide, Type I; D011994:Recombinant Proteins; D014660:Vasoactive Intestinal Peptide; D000262:Adenylyl Cyclases; D002118:Calcium