The capacity of particles to increase allergic sensitization is predicted by particle number and surface area, not by particle mass.
Nygaard
Unni Cecilie
UC
Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO-0403 Oslo, Norway. unni.cecilie.nygaard@fhi.no
Samuelsen
Mari
M
Aase
Audun
A
Løvik
Martinus
M
D000276:Adjuvants, Immunologic; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D002244:Carbon / Q000633:toxicity; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006967:Hypersensitivity / Q000473:pathology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010316:Particle Size; D010641:Phenotype; D011137:Polystyrenes / Q000633:toxicity; D011237:Predictive Value of Tests; D012044:Regression Analysis; D013499:Surface Properties; D013936:Thymidine / Q000378:metabolism; D001335:Vehicle Emissions / Q000633:toxicity
D000276:Adjuvants, Immunologic; D000954:Antigens, Surface; D016207:Cytokines; D007074:Immunoglobulin G; D011137:Polystyrenes; D001335:Vehicle Emissions; D007073:Immunoglobulin E; D002244:Carbon; D010047:Ovalbumin; D013936:Thymidine