Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Lleó
Alberto
A
Alzheimer Research Unit, Massachusetts General Hospital, 114 16th St, Charlestown, Massachusetts 02129, USA.
Berezovska
Oksana
O
Herl
Lauren
L
Raju
Susan
S
Deng
Amy
A
Bacskai
Brian J
BJ
Frosch
Matthew P
MP
Irizarry
Michael
M
Hyman
Bradley T
BT
D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016282:Aspartic Acid Endopeptidases; D016466:CHO Cells; D002352:Carrier Proteins / Q000378:metabolism*; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D010450:Endopeptidases / Q000378:metabolism*; D031541:Fluorescence Resonance Energy Transfer; D008565:Membrane Proteins / Q000737:chemistry*; D051379:Mice; D008822:Mice, Transgenic; D008958:Models, Molecular; D010446:Peptide Fragments / Q000378:metabolism*; D053764:Presenilin-1; D058255:Protease Nexins; D011487:Protein Conformation / Q000187:drug effects; D011956:Receptors, Cell Surface
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002352:Carrier Proteins; D008565:Membrane Proteins; D010446:Peptide Fragments; D053764:Presenilin-1; D058255:Protease Nexins; D011956:Receptors, Cell Surface; C086839:amyloid beta-protein (17-42); D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse