N-acetylcysteine treatment normalizes serum tumor necrosis factor-alpha level and hinders the progression of cardiac injury in hypertensive rats.
Bourraindeloup
Marie
M
Fédération de Cardiologie, Hôpital Henri Mondor, Créteil, France.
Adamy
Christophe
C
Candiani
Gabriele
G
Cailleret
Michel
M
Bourin
Marie-Claude
MC
Badoual
Thierry
T
Su
Jin Bo
JB
Adubeiro
Sylviane
S
Roudot-Thoraval
Françoise
F
Dubois-Rande
Jean-Luc
JL
Hittinger
Luc
L
Pecker
Françoise
F
D000111:Acetylcysteine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D003094:Collagen / Q000032:analysis; D018450:Disease Progression; D004353:Drug Evaluation, Preclinical; D005978:Glutathione / Q000172:deficiency / Q000502:physiology*; D006352:Heart Ventricles / Q000737:chemistry; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000032:analysis; D020780:Matrix Metalloproteinase 9 / Q000032:analysis; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000633:toxicity; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017673:Sodium Chloride, Dietary / Q000633:toxicity; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D020257:Ventricular Remodeling / Q000187:drug effects*
D000975:Antioxidants; D017673:Sodium Chloride, Dietary; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D003094:Collagen; D019001:Nitric Oxide Synthase; D013108:Sphingomyelin Phosphodiesterase; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D005978:Glutathione; D019331:NG-Nitroarginine Methyl Ester; D000111:Acetylcysteine