Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings.
Tani
Kenzaburo
K
Advanced Clinical Research Center, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. taniken@bioreg.kyushu-u.ac.jp
Azuma
Miyuki
M
Nakazaki
Yukoh
Y
Oyaizu
Naoki
N
Hase
Hidenori
H
Ohata
Junko
J
Takahashi
Keisuke
K
OiwaMonna
Maki
M
Hanazawa
Kisaburo
K
Wakumoto
Yoshiaki
Y
Kawai
Kouji
K
Noguchi
Masayuki
M
Soda
Yasushi
Y
Kunisaki
Reiko
R
Watari
Kiyoshi
K
Takahashi
Satoshi
S
Machida
Utako
U
Satoh
Noriharu
N
Tojo
Arinobu
A
Maekawa
Taira
T
Eriguchi
Masazumi
M
Tomikawa
Shinji
S
Tahara
Hideaki
H
Inoue
Yusuke
Y
Yoshikawa
Hiroki
H
Yamada
Yoshitsugu
Y
Iwamoto
Aikichi
A
Hamada
Hirofumi
H
Yamashita
Naohide
N
Okumura
Koh
K
Kakizoe
Tadao
T
Akaza
Hideyuki
H
Fujime
Makoto
M
Clift
Shirley
S
Ando
Dale
D
Mulligan
Richard
R
Asano
Shigetaka
S
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D016516:CD4-CD8 Ratio; D019496:Cancer Vaccines / Q000009:adverse effects / Q000235:genetics / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000378:metabolism / Q000628:therapy*; D016207:Cytokines / Q000276:immunology; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis; D012882:Skin Tests; D014161:Transduction, Genetic; D014611:Vaccination / Q000379:methods
D015703:Antigens, CD; D019496:Cancer Vaccines; D016207:Cytokines; D006684:HLA-DR Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016178:Granulocyte-Macrophage Colony-Stimulating Factor