Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine.
Chang
Tong-Shin
TS
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA.
Jeong
Woojin
W
Woo
Hyun Ae
HA
Lee
Sun Mi
SM
Park
Sunjoo
S
Rhee
Sue Goo
SG
D000255:Adenosine Triphosphate / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D045744:Cell Line, Tumor; D003001:Cloning, Molecular; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry*; D018076:DNA, Complementary / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000378:metabolism; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D051379:Mice; D008956:Models, Chemical; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000737:chemistry*; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D010544:Peroxidases / Q000737:chemistry* / Q000502:physiology*; D054464:Peroxiredoxins; D034622:RNA Interference; D051381:Rats; D011994:Recombinant Proteins / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013696:Temperature; D013879:Thioredoxins / Q000737:chemistry; D013997:Time Factors; D014018:Tissue Distribution
D018076:DNA, Complementary; D011994:Recombinant Proteins; D029701:Saccharomyces cerevisiae Proteins; D013879:Thioredoxins; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D010088:Oxidoreductases; D010544:Peroxidases; D054464:Peroxiredoxins; D050862:Oxidoreductases Acting on Sulfur Group Donors; C479426:SRX1 protein, S cerevisiae; C529381:sulfiredoxin protein, mouse; D005982:Glutathione Transferase; D005978:Glutathione; D003545:Cysteine; D010100:Oxygen; C013461:cysteine sulfinic acid