Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.
Manikumar
Govindarajan
G
Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Wadkins
Randy M
RM
Bearss
David
D
Von Hoff
Daniel D
DD
Wani
Mansukhlal C
MC
Wall
Monroe E
ME
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007659:Ketones / Q000737:chemistry; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
D000970:Antineoplastic Agents; D007659:Ketones; D059004:Topoisomerase I Inhibitors; D002166:Camptothecin