title: Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
authors.affiliation: Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. qun.li@abbott.com
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.forename: Akiyo
authors.initials: A
authors.lastname: Claiborne
authors.forename: Tongmei
authors.initials: T
authors.lastname: Li
authors.forename: Lisa
authors.initials: L
authors.lastname: Hasvold
authors.forename: Vincent S
authors.initials: VS
authors.lastname: Stoll
authors.forename: Steven
authors.initials: S
authors.lastname: Muchmore
authors.forename: Clarissa G
authors.initials: CG
authors.lastname: Jakob
authors.forename: Wendy
authors.initials: W
authors.lastname: Gu
authors.forename: Jerry
authors.initials: J
authors.lastname: Cohen
authors.forename: Charles
authors.initials: C
authors.lastname: Hutchins
authors.forename: David
authors.initials: D
authors.lastname: Frost
authors.forename: Saul H
authors.initials: SH
authors.lastname: Rosenberg
authors.forename: Hing L
authors.initials: HL
authors.lastname: Sham
mesh_terms: D042462:4-Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D051231:Farnesyltranstransferase; D008958:Models, Molecular; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D042462:4-Quinolones; D011728:Pyridones; D015363:Quinolones; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase; C402769:tipifarnib