Cell-specific cytotoxicity of human pancreatic adenocarcinoma cells using rat insulin promoter thymidine kinase-directed gene therapy.
Tirone
Thomas A
TA
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin, Suite 1661, 77030, Houston, Texas, USA.
Wang
Xaio-Ping
XP
Templeton
Nancy S
NS
Lee
Tim
T
Nguyen
Liz
L
Fisher
William
W
Brunicardi
F Charles
FC
D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000628:therapy*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000235:genetics*; D005240:Feasibility Studies; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007274:Injections, Intraperitoneal; D008081:Liposomes; D008099:Liver / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000628:therapy*; D051381:Rats; D018139:Simplexvirus / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000473:pathology*; D001616:beta-Galactosidase / Q000235:genetics
D018398:Homeodomain Proteins; D008081:Liposomes; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein; D013937:Thymidine Kinase; D001616:beta-Galactosidase; D015774:Ganciclovir