title: Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2'-5' oligoadenylate synthetase.
authors.affiliation: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Food and Drug Administration, HFS-025, OARSA, FDA, 8301 Muirkirk Road, Laurel, MD 20708, USA, bgoswami@cfsan.fda.gov
authors.forename: Biswendu B
authors.initials: BB
authors.lastname: Goswami
authors.forename: Michael
authors.initials: M
authors.lastname: Kulka
authors.forename: Diana
authors.initials: D
authors.lastname: Ngo
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Cebula
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D004789:Enzyme Activation; D000882:Haplorhini; D030041:Hepatitis A virus / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology*; D016899:Interferon-beta / Q000494:pharmacology*; D012335:RNA, Ribosomal / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D000227:Adenine Nucleotides; D012335:RNA, Ribosomal; D016899:Interferon-beta; D015088:2',5'-Oligoadenylate Synthetase; D020169:Caspases