Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway.
St-Pierre
Simon J G
SJ
Ottawa Health Research Institute, Molecular Medicine Program, Ottawa Hospital, General Campus, Ottawa, Canada.
Chakkalakal
Joe V
JV
Kolodziejczyk
Steven M
SM
Knudson
Jennifer C
JC
Jasmin
Bernard J
BJ
Megeney
Lynn A
LA
D021581:Active Transport, Cell Nucleus; D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004789:Enzyme Activation; D051379:Mice; D018101:Mice, Inbred mdx; D048055:Mitogen-Activated Protein Kinase 8 / Q000037:antagonists & inhibitors; D018485:Muscle Fibers, Skeletal / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins / Q000378:metabolism*; D011282:Pregnenediones / Q000494:pharmacology* / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000378:metabolism*; D015533:Transcriptional Activation; D049411:Utrophin / Q000378:metabolism
D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D011282:Pregnenediones; D014157:Transcription Factors; D049411:Utrophin; D048055:Mitogen-Activated Protein Kinase 8; D019703:Calcineurin; C021988:deflazacort