Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB.
Imose
Motoaki
M
First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan.
Nagaki
Masahito
M
Kimura
Kiminori
K
Takai
Shinji
S
Imao
Motohiro
M
Naiki
Takafumi
T
Osawa
Yosuke
Y
Asano
Takahiko
T
Hayashi
Hideki
H
Moriwaki
Hisataka
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D061945:Caspase Inhibitors; D002478:Cells, Cultured; D003208:Concanavalin A / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D006505:Hepatitis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D007555:Isoxazoles / Q000494:pharmacology*; D000077339:Leflunomide; D008099:Liver / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D012333:RNA, Messenger / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D061945:Caspase Inhibitors; D016207:Cytokines; D007376:Interleukin-2; D007555:Isoxazoles; D016328:NF-kappa B; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A; D007371:Interferon-gamma; D020928:Mitogen-Activated Protein Kinases; D000077339:Leflunomide