p38 alpha mitogen-activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol-induced acute myocardial injury in rats.
Li
Zhihe
Z
Department of Pharmacology and Preclinical Research, Scios Inc., Fremont, CA 94555, USA. li@sciosinc.com
Tran
Thomas-Toan
TT
Ma
Jing Ying
JY
O'Young
Gilbert
G
Kapoun
Ann M
AM
Chakravarty
Sarvajit
S
Dugar
Sundeep
S
Schreiner
George
G
Protter
Andrew A
AA
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007545:Isoproterenol; D008297:Male; D048308:Mitogen-Activated Protein Kinase 14 / Q000037:antagonists & inhibitors*; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D009929:Organ Size / Q000187:drug effects; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
D002316:Cardiotonic Agents; D012333:RNA, Messenger; D048308:Mitogen-Activated Protein Kinase 14; D007545:Isoproterenol