Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Li
Qun
Q
Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. qun.li@abbott.com
Claiborne
Akiyo
A
Li
Tongmei
T
Hasvold
Lisa
L
Stoll
Vincent S
VS
Muchmore
Steven
S
Jakob
Clarissa G
CG
Gu
Wendy
W
Cohen
Jerry
J
Hutchins
Charles
C
Frost
David
D
Rosenberg
Saul H
SH
Sham
Hing L
HL
D042462:4-Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D051231:Farnesyltranstransferase; D008958:Models, Molecular; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000737:chemistry; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D011728:Pyridones; D015363:Quinolones; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase; C402769:tipifarnib