Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].
Cardillo
Giuliana
G
Dipartimento di Chimica G. Ciamician and CSFM, via Selmi 2, Università di Bologna, 40126 Bologna, Italy. giuliana.cardillo@unibo.it
Gentilucci
Luca
L
Tolomelli
Alessandra
A
Spinosa
Raffaella
R
Calienni
Maria
M
Qasem
Ahmed R
AR
Spampinato
Santi
S
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D000242:Cyclic AMP / Q000096:biosynthesis; D066298:In Vitro Techniques; D008024:Ligands; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D017450:Receptors, Opioid, mu / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship
D008024:Ligands; D010456:Peptides, Cyclic; D017450:Receptors, Opioid, mu; C492968:cyclo(tyrosyl-prolyl-tryptophyl-phenylalanyl-glycyl); D000242:Cyclic AMP