Blocking the anoxic depolarization protects without functional compromise following simulated stroke in cortical brain slices.
Anderson
Trent R
TR
Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada.
Jarvis
Cathryn R
CR
Biedermann
Alyson J
AJ
Molnar
Christine
C
Andrew
R David
RD
D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017480:Receptors, sigma / Q000502:physiology; D020521:Stroke / Q000503:physiopathology* / Q000517:prevention & control
D018696:Neuroprotective Agents; D017480:Receptors, sigma; D010042:Ouabain