The human SCGB2A2 (mammaglobin-1) promoter/enhancer in a helper-dependent adenovirus vector directs high levels of transgene expression in mammary carcinoma cells but not in normal nonmammary cells.
Shi
Chang-Xin
CX
Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5.
Long
Michael A
MA
Liu
Limin
L
Graham
Frank L
FL
Gauldie
Jack
J
Hitt
Mary M
MM
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D020029:Base Pairing; D001943:Breast Neoplasms / Q000378:metabolism* / Q000628:therapy; D002277:Carcinoma / Q000378:metabolism* / Q000628:therapy; D045744:Cell Line, Tumor; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D017930:Genes, Reporter / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics*; D006378:Helper Viruses / Q000235:genetics; D006801:Humans; D008156:Luciferases / Q000032:analysis / Q000235:genetics; D060785:Mammaglobin A; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000628:therapy; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017384:Sequence Deletion / Q000235:genetics; D014598:Uteroglobin / Q000235:genetics*
D060785:Mammaglobin A; D009363:Neoplasm Proteins; C556448:SCGB2A2 protein, human; D014598:Uteroglobin; D008156:Luciferases