title: Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
authors.affiliation: Neurology and Gastrointestinal Diseases, Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Beswick
authors.forename: Sharon
authors.initials: S
authors.lastname: Bingham
authors.forename: Chas
authors.initials: C
authors.lastname: Bountra
authors.forename: Terry
authors.initials: T
authors.lastname: Brown
authors.forename: Kerry
authors.initials: K
authors.lastname: Browning
authors.forename: Ian
authors.initials: I
authors.lastname: Campbell
authors.forename: Iain
authors.initials: I
authors.lastname: Chessell
authors.forename: Nick
authors.initials: N
authors.lastname: Clayton
authors.forename: Sue
authors.initials: S
authors.lastname: Collins
authors.forename: John
authors.initials: J
authors.lastname: Corfield
authors.forename: Stephen
authors.initials: S
authors.lastname: Guntrip
authors.forename: Claudine
authors.initials: C
authors.lastname: Haslam
authors.forename: Paul
authors.initials: P
authors.lastname: Lambeth
authors.forename: Fiona
authors.initials: F
authors.lastname: Lucas
authors.forename: Neil
authors.initials: N
authors.lastname: Mathews
authors.forename: Graham
authors.initials: G
authors.lastname: Murkit
authors.forename: Alan
authors.initials: A
authors.lastname: Naylor
authors.forename: Neil
authors.initials: N
authors.lastname: Pegg
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pickup
authors.forename: Hazel
authors.initials: H
authors.lastname: Player
authors.forename: Helen
authors.initials: H
authors.lastname: Price
authors.forename: Alexander
authors.initials: A
authors.lastname: Stevens
authors.forename: Sharon
authors.initials: S
authors.lastname: Stratton
authors.forename: Joanne
authors.initials: J
authors.lastname: Wiseman
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy; D001682:Biological Availability; D001921:Brain / Q000378:metabolism; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D005620:Freund's Adjuvant; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry* / Q000378:metabolism; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D008565:Membrane Proteins; D011720:Pyrazoles; D011724:Pyridazines; D005620:Freund's Adjuvant; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases