title: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
authors.affiliation: Department of Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Chiocco
authors.forename: Laura Shapiro
authors.initials: LS
authors.lastname: Kulnane
authors.forename: Linda
authors.initials: L
authors.lastname: Younkin
authors.forename: Steve
authors.initials: S
authors.lastname: Younkin
authors.forename: Geneviève
authors.initials: G
authors.lastname: Evin
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Lamb
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000235:genetics* / Q000378:metabolism*; D010450:Endopeptidases; D005260:Female; D015870:Gene Expression; D023281:Genomics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D012333:RNA, Messenger; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse