Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.
Genovese
Tiziana
T
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C. Valeria, Gazzi, 98100 Messina, Italy.
Mazzon
Emanuela
E
Muià
Carmelo
C
Patel
Nimesh S A
NS
Threadgill
Michael D
MD
Bramanti
Placido
P
De Sarro
Angelina
A
Thiemermann
Christoph
C
Cuzzocrea
Salvatore
S
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001549:Benzamides / Q000494:pharmacology / Q000627:therapeutic use; D015153:Blotting, Western; D002467:Cell Nucleus / Q000187:drug effects / Q000201:enzymology; D003720:Densitometry; D024202:Electrophoretic Mobility Shift Assay; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D020672:I-kappa B Proteins / Q000378:metabolism; D020287:In Situ Nick-End Labeling; D007546:Isoquinolines / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000473:pathology*
C411425:5-aminoisoquinolinone; D001549:Benzamides; D004791:Enzyme Inhibitors; D020672:I-kappa B Proteins; D007546:Isoquinolines; D016328:NF-kappa B; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C025160:3-aminobenzamide; D009195:Peroxidase; D011065:Poly(ADP-ribose) Polymerases