title: Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein.
authors.affiliation: Structural Biology Laboratory, Nara Institute of Science and Technology, CREST, Japan Science and Technology Agency, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Maita
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hatakeyama
authors.forename: Kengo
authors.initials: K
authors.lastname: Okada
authors.forename: Toshio
authors.initials: T
authors.lastname: Hakoshima
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001708:Biopterins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism; D006136:GTP Cyclohydrolase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D005786:Gene Expression Regulation; D047908:Intracellular Signaling Peptides and Proteins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D010455:Peptides / Q000737:chemistry; D010649:Phenylalanine / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D051381:Rats
chemical_list: C491065:Gchfr protein, rat; D047908:Intracellular Signaling Peptides and Proteins; D010455:Peptides; D011506:Proteins; D001708:Biopterins; D010649:Phenylalanine; D004295:Dihydroxyphenylalanine; D006136:GTP Cyclohydrolase