title: Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh and McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, USA. HBreslin@prdus.jnj.com
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Breslin
authors.forename: Tamara A
authors.initials: TA
authors.lastname: Miskowski
authors.forename: Bryan M
authors.initials: BM
authors.lastname: Rafferty
authors.forename: Santosh V
authors.initials: SV
authors.lastname: Coutinho
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Palmer
authors.forename: Nathaniel H
authors.initials: NH
authors.lastname: Wallace
authors.forename: Craig R
authors.initials: CR
authors.lastname: Schneider
authors.forename: Edward S
authors.initials: ES
authors.lastname: Kimball
authors.forename: Sui-Po
authors.initials: SP
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Raymond W
authors.initials: RW
authors.lastname: Colburn
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Stone
authors.forename: Rebecca P
authors.initials: RP
authors.lastname: Martinez
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D000009:Abdominal Muscles / Q000187:drug effects / Q000502:physiology; D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D005769:Gastrointestinal Motility / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009119:Muscle Contraction / Q000187:drug effects; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists*; D017465:Receptors, Opioid, delta / Q000819:agonists; D017450:Receptors, Opioid, mu / Q000819:agonists; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D007093:Imidazoles; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu