title: Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
authors.affiliation: Cyclacel Limited, James Lindsay Place, Dundee, Scotland, UK. mandrews@cyclacel.com
authors.forename: Martin J I
authors.initials: MJ
authors.lastname: Andrews
authors.forename: Campbell
authors.initials: C
authors.lastname: McInnes
authors.forename: George
authors.initials: G
authors.lastname: Kontopidis
authors.forename: Lorraine
authors.initials: L
authors.lastname: Innes
authors.forename: Angela
authors.initials: A
authors.lastname: Cowan
authors.forename: Andy
authors.initials: A
authors.lastname: Plater
authors.forename: Peter M
authors.initials: PM
authors.lastname: Fischer
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D019295:Computational Biology; D018360:Crystallography, X-Ray; D019925:Cyclin A / Q000737:chemistry; D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000187:drug effects; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011487:Protein Conformation
chemical_list: D019925:Cyclin A; D009097:Multienzyme Complexes; D019151:Peptide Library; D010456:Peptides, Cyclic; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051357:Cyclin-Dependent Kinase 2