Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques.
Fukumoto
Yoshihiro
Y
Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Medicine, and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA.
Deguchi
Jun-o
JO
Libby
Peter
P
Rabkin-Aikawa
Elena
E
Sakata
Yasuhiko
Y
Chin
Michael T
MT
Hill
Christopher C
CC
Lawler
Patrick R
PR
Varo
Nerea
N
Schoen
Frederick J
FJ
Krane
Stephen M
SM
Aikawa
Masanori
M
D019943:Amino Acid Substitution; D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D002452:Cell Count; D016923:Cell Death; D002465:Cell Movement; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism*; D017364:Collagenases / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D003433:Crosses, Genetic; D004036:Diet, Atherogenic; D008264:Macrophages / Q000201:enzymology*; D017737:Macrophages, Peritoneal / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D013379:Substrate Specificity / Q000235:genetics; D017539:Tunica Intima / Q000473:pathology
D001057:Apolipoproteins E; D024042:Collagen Type I; D017364:Collagenases