Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation.
Sutherland
May Kung
MK
Department of Gene Function & Target Validation, Celltech R & D, Inc, Bothell, WA 98021, USA.
Geoghegan
James C
JC
Yu
Changpu
C
Turcott
Eileen
E
Skonier
John E
JE
Winkler
David G
DG
Latham
John A
JA
D048868:Adaptor Proteins, Signal Transducing; D000469:Alkaline Phosphatase / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D010012:Osteogenesis / Q000187:drug effects / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D061945:Caspase Inhibitors; D004791:Enzyme Inhibitors; D005819:Genetic Markers; C422903:SOST protein, human; D000469:Alkaline Phosphatase; D020169:Caspases