Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
Kim
Seong-Hun
SH
Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.
Yin
Ye Ingrid
YI
Li
Yue-Ming
YM
Sisodia
Sangram S
SS
D020816:Amino Acid Motifs; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry; D016282:Aspartic Acid Endopeptidases; D001577:Benzophenones / Q000494:pharmacology; D001665:Binding Sites; D019921:Biotinylation; D015153:Blotting, Western; D002384:Catalysis; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002474:Cell-Free System; D003432:Cross-Linking Reagents / Q000494:pharmacology; D018076:DNA, Complementary / Q000378:metabolism; D010450:Endopeptidases / Q000737:chemistry*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000939:Epitopes / Q000737:chemistry; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry; D010447:Peptide Hydrolases; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D051880:Receptors, Notch; D014162:Transfection; D021601:trans-Golgi Network / Q000737:chemistry
D016564:Amyloid beta-Protein Precursor; D001577:Benzophenones; D003432:Cross-Linking Reagents; D018076:DNA, Complementary; D004791:Enzyme Inhibitors; D000939:Epitopes; D008565:Membrane Proteins; C469349:PSENEN protein, human; D051880:Receptors, Notch; C047723:benzophenone; C475154:APH1A protein, human; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D010447:Peptide Hydrolases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human