title: Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.
authors.affiliation: Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy. mario.sechi@uniss.it
authors.forename: Mario
authors.initials: M
authors.lastname: Sechi
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Derudas
authors.forename: Roberto
authors.initials: R
authors.lastname: Dallocchio
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dessì
authors.forename: Alessia
authors.initials: A
authors.lastname: Bacchi
authors.forename: Luciano
authors.initials: L
authors.lastname: Sannia
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Carta
authors.forename: Michele
authors.initials: M
authors.lastname: Palomba
authors.forename: Omar
authors.initials: O
authors.lastname: Ragab
authors.forename: Carney
authors.initials: C
authors.lastname: Chan
authors.forename: Robert
authors.initials: R
authors.lastname: Shoemaker
authors.forename: Shizuko
authors.initials: S
authors.lastname: Sei
authors.forename: Raveendra
authors.initials: R
authors.lastname: Dayam
authors.forename: Nouri
authors.initials: N
authors.lastname: Neamati
mesh_terms: D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D015195:Drug Design; D019427:HIV Integrase / Q000737:chemistry / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007651:Keto Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D012996:Solutions; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000821:virology
chemical_list: D019428:HIV Integrase Inhibitors; D007211:Indoles; D007651:Keto Acids; D012996:Solutions; D019427:HIV Integrase