Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion.
De Corte
Veerle
V
Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology (V.I.B.), Ghent University, Faculty of Medicine and Health Sciences, Albert Baertsoenkaai 3, 9000 Ghent, Belgium.
Van Impe
Katrien
K
Bruyneel
Erik
E
Boucherie
Ciska
C
Mareel
Marc
M
Vandekerckhove
Joël
J
Gettemans
Jan
J
D000199:Actins / Q000737:chemistry / Q000378:metabolism*; D021581:Active Transport, Cell Nucleus; D000595:Amino Acid Sequence; D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D003094:Collagen / Q000737:chemistry; D003593:Cytoplasm / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D008156:Luciferases / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009687:Nuclear Proteins / Q000378:metabolism*; D010587:Phagocytosis; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017354:Point Mutation; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D014162:Transfection; D028961:beta Karyopherins / Q000378:metabolism / Q000502:physiology*; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
D000199:Actins; D008840:Microfilament Proteins; D009687:Nuclear Proteins; D028961:beta Karyopherins; D049452:Green Fluorescent Proteins; C066575:CAPG protein, human; D003094:Collagen; D008156:Luciferases; D019869:Phosphatidylinositol 3-Kinases; D020764:cdc42 GTP-Binding Protein; D020742:rhoA GTP-Binding Protein