title: O6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course.
authors.affiliation: Department of Neurological Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-kamumachi, Itabashi-ku, Tokyo 173-8610, Japan. takao@med.nihon-u.ac.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Katayama
authors.forename: Chiaki
authors.initials: C
authors.lastname: Komine
authors.forename: Atsuo
authors.initials: A
authors.lastname: Yoshino
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Ogino
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohta
authors.forename: Takao
authors.initials: T
authors.lastname: Fukushima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D001932:Brain Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D019175:DNA Methylation; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016899:Interferon-beta / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D015376:Nimustine / Q000494:pharmacology; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics; D011446:Prospective Studies; D011829:Radiation Dosage; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53; D015376:Nimustine; D016899:Interferon-beta; D019853:O(6)-Methylguanine-DNA Methyltransferase