Acetylcholine-induced relaxation of rabbit basilar artery in vitro is rapidly reduced by reactive oxygen species in acute hyperglycemia: role of NADPH oxidase.
Sercombe
Richard
R
Laboratory for Microcirculation Research, Faculty of Medicine, University Paris VII, Paris, France. sercombe@ext.jussieu.fr
Vicaut
Eric
E
Oudart
Nicole
N
Sercombe
Christine
C
Girard
Pierre
P
D000109:Acetylcholine / Q000494:pharmacology*; D000208:Acute Disease; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006943:Hyperglycemia / Q000378:metabolism / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009994:Osmolar Concentration; D011817:Rabbits; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D014665:Vasodilator Agents; D019255:NADPH Oxidases; D005947:Glucose; D000109:Acetylcholine