title: MAPK cascade possesses decoupled controllability of signal amplification and duration.
authors.affiliation: Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716, USA.
authors.forename: Kapil
authors.initials: K
authors.lastname: Mayawala
authors.forename: Claudio A
authors.initials: CA
authors.lastname: Gelmi
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Edwards
mesh_terms: D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D015536:Down-Regulation; D004705:Endocytosis / Q000502:physiology; D004789:Enzyme Activation / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism*; D005246:Feedback / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D020935:MAP Kinase Signaling System / Q000187:drug effects; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D020928:Mitogen-Activated Protein Kinases