Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.
Yu
Guo-Liang
GL
Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China.
Wei
Er-Qing
EQ
Zhang
Shi-Hong
SH
Xu
Hui-Ming
HM
Chu
Li-Sheng
LS
Zhang
Wei-Ping
WP
Zhang
Qi
Q
Chen
Zhong
Z
Mei
Ru-Huan
RH
Zhao
Meng-Hui
MH
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000188:drug therapy / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002867:Chromones / Q000494:pharmacology; D003521:Cyclopropanes; D004305:Dose-Response Relationship, Drug; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000627:therapeutic use; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy / Q000473:pathology; D020024:Leukotriene Antagonists / Q000494:pharmacology*; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011597:Psychomotor Performance / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D018077:Receptors, Leukotriene / Q000187:drug effects*; D013440:Sulfides; D016019:Survival Analysis; D013997:Time Factors
D000085:Acetates; D002867:Chromones; D003521:Cyclopropanes; D016166:Free Radical Scavengers; D020024:Leukotriene Antagonists; D018696:Neuroprotective Agents; D011804:Quinolines; D018077:Receptors, Leukotriene; D013440:Sulfides; C093875:montelukast; D000077553:Edaravone; D000983:Antipyrine; C047681:pranlukast