Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine.
Parekh-Olmedo
Hetal
H
Department of Biological Sciences, University of Delaware, Delaware Biotechnology Institute, Newark, DE 19711, USA.
Wang
Jin
J
Gusella
James F
JF
Kmiec
Eric B
EB
D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D042622:DNA Repeat Expansion; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism; D002479:Inclusion Bodies; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D016017:Odds Ratio; D009841:Oligonucleotides / Q000235:genetics / Q000378:metabolism*; D016716:PC12 Cells; D010455:Peptides / Q000378:metabolism* / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
C499524:Htt protein, rat; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D009841:Oligonucleotides; D010455:Peptides; D011993:Recombinant Fusion Proteins; C097188:polyglutamine