Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor.
Wheatcroft
Stephen B
SB
Department of Cardiology, Guy's King's & St. Thomas' School of Medicine, King's College London, Bessemer Road, London SE5 9PJ, UK.
Shah
Ajay M
AM
Li
Jian-Mei
JM
Duncan
Edward
E
Noronha
Brian T
BT
Crossey
Paul A
PA
Kearney
Mark T
MT
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006579:Heterozygote; D006706:Homeostasis; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011972:Receptor, Insulin / Q000172:deficiency* / Q000235:genetics*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D019323:omega-N-Methylarginine / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D009599:Nitroprusside; D010656:Phenylephrine; D019323:omega-N-Methylarginine; D019001:Nitric Oxide Synthase; D011972:Receptor, Insulin; D005947:Glucose; D000109:Acetylcholine