GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state.
Laviolette
Steven R
SR
Neurobiology Research Group, Department of Anatomy & Cell Biology, University of Toronto, Toronto, Ontario Canada M5S 1A8. laviolette@bns.pitt.edu
van der Kooy
Derek
D
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000378:metabolism*; D045042:Pedunculopontine Tegmental Nucleus / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D012201:Reward; D013375:Substance Withdrawal Syndrome / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000378:metabolism*
D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A; D009118:Muscimol; D001640:Bicuculline