title: LEAPT: lectin-directed enzyme-activated prodrug therapy.
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Robinson
authors.forename: Stuart T
authors.initials: ST
authors.lastname: Charlton
authors.forename: Philippe
authors.initials: P
authors.lastname: Garnier
authors.forename: Xiang-tao
authors.initials: XT
authors.lastname: Wang
authors.forename: Stanley S
authors.initials: SS
authors.lastname: Davis
authors.forename: Alan C
authors.initials: AC
authors.lastname: Perkins
authors.forename: Malcolm
authors.initials: M
authors.lastname: Frier
authors.forename: Ruth
authors.initials: R
authors.lastname: Duncan
authors.forename: Tony J
authors.initials: TJ
authors.lastname: Savage
authors.forename: David A
authors.initials: DA
authors.lastname: Wyatt
authors.forename: Susan A
authors.initials: SA
authors.lastname: Watson
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Davis
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics / Q000627:therapeutic use; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D016503:Drug Delivery Systems; D004789:Enzyme Activation; D004795:Enzyme Stability; D006026:Glycoside Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007668:Kidney / Q000378:metabolism; D037102:Lectins; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011355:Prodrugs / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015202:Protein Engineering; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D000903:Antibiotics, Antineoplastic; D037102:Lectins; D011355:Prodrugs; D004317:Doxorubicin; D006026:Glycoside Hydrolases; C022525:alpha-L-rhamnosidase