title: Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
authors.affiliation: Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. qun.li@abbott.com
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.forename: Gary T
authors.initials: GT
authors.lastname: Wang
authors.forename: Tongmei
authors.initials: T
authors.lastname: Li
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Gwaltney
authors.forename: Keith W
authors.initials: KW
authors.lastname: Woods
authors.forename: Akiyo
authors.initials: A
authors.lastname: Claiborne
authors.forename: Xilu
authors.initials: X
authors.lastname: Wang
authors.forename: Wendy
authors.initials: W
authors.lastname: Gu
authors.forename: Jerry
authors.initials: J
authors.lastname: Cohen
authors.forename: Vincent S
authors.initials: VS
authors.lastname: Stoll
authors.forename: Charles
authors.initials: C
authors.lastname: Hutchins
authors.forename: David
authors.initials: D
authors.lastname: Frost
authors.forename: Saul H
authors.initials: SH
authors.lastname: Rosenberg
authors.forename: Hing L
authors.initials: HL
authors.lastname: Sham
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002461:Cell Line, Transformed; D018360:Crystallography, X-Ray; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051231:Farnesyltranstransferase; D011905:Genes, ras; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008958:Models, Molecular; D041681:NIH 3T3 Cells; D015363:Quinolones / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004987:Ethers; D007093:Imidazoles; D015363:Quinolones; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase; C402769:tipifarnib