A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats.
Cui
Guang-Hui
GH
Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Xu
Zeng-Lu
ZL
Yang
Zhan-Jun
ZJ
Xu
Yuan-Yuan
YY
Xue
She-Pu
SP
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D020169:Caspases / Q000235:genetics; D003272:Contraceptive Agents, Male / Q000008:administration & dosage* / Q000009:adverse effects; D053938:DNA Fragmentation; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D006072:Gossypol / Q000008:administration & dosage* / Q000009:adverse effects; D017403:In Situ Hybridization; D020287:In Situ Nick-End Labeling; D008297:Male; D008777:Methyltestosterone / Q000008:administration & dosage*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D051028:bcl-2-Associated X Protein; D019014:fas Receptor / Q000235:genetics
C494828:Bax protein, rat; D003272:Contraceptive Agents, Male; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D051028:bcl-2-Associated X Protein; D019014:fas Receptor; D004997:Ethinyl Estradiol; D020169:Caspases; D006072:Gossypol; D008777:Methyltestosterone