Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.
Koehler
Niklas K U
NK
Departments of Microbiology and Immunology, Neurology, and Pathology, Georgetown University Medical Center, Washington, D.C. 20007, USA.
Yang
Chao-Yie
CY
Varady
Judith
J
Lu
Yipin
Y
Wu
Xiong-Wu
XW
Liu
Ming
M
Yin
Daxu
D
Bartels
Margreet
M
Xu
Bi-ying
BY
Roller
Peter P
PP
Long
Ya-qiu
YQ
Li
Peng
P
Kattah
Michael
M
Cohn
Marjorie L
ML
Moran
Kelly
K
Tilley
Eurona
E
Richert
John R
JR
Wang
Shaomeng
S
D000818:Animals; D001391:Azo Compounds / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001667:Binding, Competitive; D002460:Cell Line; D016208:Databases, Factual; D006684:HLA-DR Antigens / Q000737:chemistry / Q000276:immunology*; D059811:HLA-DRB1 Chains; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D051379:Mice; D008958:Models, Molecular; D004676:Myelin Basic Protein / Q000737:chemistry / Q000276:immunology*; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*; D011810:Quinoxalines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D001391:Azo Compounds; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C492962:HLA-DRB1*13:01 antigen; C489631:HLA-DRB1*15:01 antigen; D007376:Interleukin-2; D004676:Myelin Basic Protein; D009281:Naphthalenes; D010446:Peptide Fragments; D011810:Quinoxalines; C492963:myelin basic protein 152-165