Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a double-blind, placebo-controlled randomised multicenter trial [ISRCTN38327949].
Besselink
Marc G H
MG
Department of Surgery, University Medical Center Utrecht PO Box 85500, HP G04,228, 3508 GA Utrecht, The Netherlands. m.besselink@chir.azu.nl
Timmerman
Harro M
HM
Buskens
Erik
E
Nieuwenhuijs
Vincent B
VB
Akkermans
Louis M A
LM
Gooszen
Hein G
HG
D000208:Acute Disease; D000328:Adult; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D048191:Lactiplantibacillus plantarum; D015337:Multicenter Studies as Topic; D009336:Necrosis / Q000517:prevention & control; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000517:prevention & control*; D019936:Probiotics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D018401:Sample Size