Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.
Dervieux
Thierry
T
Prometheus Laboratories, San Diego, California, USA.
Furst
Daniel
D
Lein
Diana Orentas
DO
Capps
Robert
R
Smith
Katie
K
Walsh
Michael
M
Kremer
Joel
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018501:Antirheumatic Agents / Q000378:metabolism / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics; D003430:Cross-Sectional Studies; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D019877:Hydroxymethyl and Formyl Transferases / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics*; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use*; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000235:genetics; D009709:Nucleotide Deaminases / Q000235:genetics; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D058978:Reduced Folate Carrier Protein; D013940:Thymidylate Synthase / Q000235:genetics*; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D002352:Carrier Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009097:Multienzyme Complexes; D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human; C120043:SLC19A2 protein, human; C113120:inosine monophosphate synthase; D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D013940:Thymidylate Synthase; D019877:Hydroxymethyl and Formyl Transferases; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase; D009709:Nucleotide Deaminases; D008727:Methotrexate