Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease.
Jana
Arundhati
A
Section of Neuroscience, Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA.
Pahan
Kalipada
K
D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000502:physiology*; D017209:Apoptosis; D002470:Cell Survival; D002478:Cells, Cultured; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D019852:Diacylglycerol Kinase / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000494:pharmacology; D019271:Hypoxanthine / Q000737:chemistry; D020287:In Situ Nick-End Labeling; D008055:Lipids / Q000737:chemistry; D026901:Membrane Transport Proteins / Q000378:metabolism; D009252:NADPH Dehydrogenase / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D016376:Oligonucleotides, Antisense / Q000737:chemistry; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D010446:Peptide Fragments / Q000737:chemistry / Q000502:physiology*; D010455:Peptides / Q000737:chemistry*; D010750:Phosphoproteins / Q000378:metabolism; D017382:Reactive Oxygen Species; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*; D013481:Superoxides / Q000737:chemistry; D013997:Time Factors; D014969:Xanthine Oxidase / Q000737:chemistry
D016229:Amyloid beta-Peptides; D002518:Ceramides; D008055:Lipids; D026901:Membrane Transport Proteins; D016376:Oligonucleotides, Antisense; D010446:Peptide Fragments; D010455:Peptides; D010750:Phosphoproteins; D017382:Reactive Oxygen Species; C075222:amyloid beta-protein (1-42); D013481:Superoxides; D019271:Hypoxanthine; D004247:DNA; D006861:Hydrogen Peroxide; D014969:Xanthine Oxidase; D019255:NADPH Oxidases; C086986:CYBA protein, human; D009252:NADPH Dehydrogenase; D019852:Diacylglycerol Kinase; D013108:Sphingomyelin Phosphodiesterase; D010100:Oxygen