title: ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages.
authors.affiliation: CEA, Service de Neurovirologie, Université Paris XI, CRSSA, EPHE, IPSC, Fontenay-aux-Roses, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Jorajuria
authors.forename: Nathalie
authors.initials: N
authors.lastname: Dereuddre-Bosquet
authors.forename: François
authors.initials: F
authors.lastname: Becher
authors.forename: Solenne
authors.initials: S
authors.lastname: Martin
authors.forename: Fabrice
authors.initials: F
authors.lastname: Porcheray
authors.forename: Alexia
authors.initials: A
authors.lastname: Garrigues
authors.forename: Aloise
authors.initials: A
authors.lastname: Mabondzo
authors.forename: Henri
authors.initials: H
authors.lastname: Benech
authors.forename: Jacques
authors.initials: J
authors.lastname: Grassi
authors.forename: Stéphane
authors.initials: S
authors.lastname: Orlowski
authors.forename: Dominique
authors.initials: D
authors.lastname: Dormont
authors.forename: Pascal
authors.initials: P
authors.lastname: Clayette
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D019469:Indinavir / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism / Q000821:virology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism / Q000821:virology; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000378:metabolism; D011339:Probenecid / Q000494:pharmacology; D012333:RNA, Messenger / Q000032:analysis; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D015215:Zidovudine / Q000494:pharmacology*
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D003524:Cyclosporins; D017320:HIV Protease Inhibitors; D019469:Indinavir; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D011339:Probenecid; D012333:RNA, Messenger; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; C073492:ABCC4 protein, human; C120809:ABCC5 protein, human; C070272:valspodar