Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters.
Gustavson
Mark D
MD
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232-6840, USA.
Crawford
Howard C
HC
Fingleton
Barbara
B
Matrisian
Lynn M
LM
D000818:Animals; D001665:Binding Sites; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D016384:Consensus Sequence / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D005786:Gene Expression Regulation; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008156:Luciferases / Q000378:metabolism; D051821:Lymphoid Enhancer-Binding Factor 1; D020783:Matrix Metalloproteinase 7 / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D016296:Mutagenesis; D009154:Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D024363:Transcription Initiation Site / Q000502:physiology*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D014162:Transfection; D051176:beta Catenin
C495270:CTNNB1 protein, human; C495267:CTNNB1 protein, mouse; D015820:Cadherins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; C497573:LEF1 protein, human; C497574:Lef1 protein, mouse; D051821:Lymphoid Enhancer-Binding Factor 1; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin; D008156:Luciferases; D020783:Matrix Metalloproteinase 7