Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
Yamashita
Ayako
A
Chemical and Screening Sciences and Oncology Research, Wyeth Research, Pearl River, NY 10965, USA. ay2122@columbia.edu
Norton
Emily B
EB
Kaplan
Joshua A
JA
Niu
Chuan
C
Loganzo
Frank
F
Hernandez
Richard
R
Beyer
Carl F
CF
Annable
Tami
T
Musto
Sylvia
S
Discafani
Carolyn
C
Zask
Arie
A
Ayral-Kaloustian
Semiramis
S
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001704:Biopolymers; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007624:KB Cells; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008819:Mice, Nude; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry*; D050257:Tubulin Modulators; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents; D001704:Biopolymers; C473896:HTI-286; D009842:Oligopeptides; D014404:Tubulin; D050257:Tubulin Modulators; C467070:hemiasterlin