Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein.
Ellert-Miklaszewska
Aleksandra
A
Department of Biochemistry and Clinical Chemistry, Medical Academy of Warsaw, Poland.
Kaminska
Bozena
B
Konarska
Liliana
L
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D048588:Benzoxazines; D002186:Cannabinoids / Q000494:pharmacology*; D002352:Carrier Proteins / Q000502:physiology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D005910:Glioma; D007700:Kinetics; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology*; D009025:Morpholines / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology*; D019869:Phosphatidylinositol 3-Kinases / Q000187:drug effects / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D051381:Rats; D051025:bcl-Associated Death Protein
D048588:Benzoxazines; D002186:Cannabinoids; D002352:Carrier Proteins; D009025:Morpholines; D009281:Naphthalenes; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; D051025:bcl-Associated Death Protein; C494821:Bad protein, rat; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; C494920:Akt1 protein, rat