title: Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones.
authors.affiliation: Merck Research Laboratories, MRLSDB2, 3535 General Atomics Court, San Diego, CA 92121, USA. anthony_pinkerton@merck.com
authors.forename: Anthony B
authors.initials: AB
authors.lastname: Pinkerton
authors.forename: Rowena V
authors.initials: RV
authors.lastname: Cube
authors.forename: John H
authors.initials: JH
authors.lastname: Hutchinson
authors.forename: Blake A
authors.initials: BA
authors.lastname: Rowe
authors.forename: Hervé
authors.initials: H
authors.lastname: Schaffhauser
authors.forename: Xiumin
authors.initials: X
authors.lastname: Zhao
authors.forename: Lorrie P
authors.initials: LP
authors.lastname: Daggett
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Vernier
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000494:Allosteric Regulation; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000098:Acetophenones; D018094:Receptors, Metabotropic Glutamate; D013777:Tetrazoles; C108822:metabotropic glutamate receptor 2