Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation.
Chang
Ya Jen
YJ
Department of Pharmacology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan.
Wu
Ming Shiang
MS
Lin
Jaw Town
JT
Sheu
Bor Shyang
BS
Muta
Tatsushi
T
Inoue
Hiroyasu
H
Chen
Ching-Chow
CC
D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D051546:Cyclooxygenase 2; D004789:Enzyme Activation; D005753:Gastric Mucosa / Q000201:enzymology* / Q000382:microbiology; D015971:Gene Expression Regulation, Enzymologic; D016391:Genes, src / Q000502:physiology*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008562:Membrane Glycoproteins / Q000502:physiology*; D008565:Membrane Proteins; D008745:Methylation; D016328:NF-kappa B / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000502:physiology*; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors
D022762:CCAAT-Enhancer-Binding Proteins; D017362:Cyclic AMP Response Element-Binding Protein; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D016328:NF-kappa B; D011956:Receptors, Cell Surface; C495342:TLR2 protein, human; C495345:TLR4 protein, human; C495371:TLR9 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases