The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.
Screaton
Robert A
RA
Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Conkright
Michael D
MD
Katoh
Yoshiko
Y
Best
Jennifer L
JL
Canettieri
Gianluca
G
Jeffries
Shawn
S
Guzman
Ernesto
E
Niessen
Sherry
S
Yates
John R
JR
Takemori
Hiroshi
H
Okamoto
Mitsuhiro
M
Montminy
Marc
M
D048948:14-3-3 Proteins / Q000378:metabolism; D021581:Active Transport, Cell Nucleus / Q000235:genetics; D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D005947:Glucose / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism; D046911:Macromolecular Substances; D051379:Mice; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D034741:RNA, Small Interfering; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors
D048948:14-3-3 Proteins; C493245:CRTC2 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D006728:Hormones; D046911:Macromolecular Substances; D010750:Phosphoproteins; D034741:RNA, Small Interfering; D015534:Trans-Activators; D014157:Transcription Factors; D000242:Cyclic AMP; C474808:salt-inducible kinase-2, mouse; D017346:Protein Serine-Threonine Kinases; D019703:Calcineurin; D005947:Glucose; D002118:Calcium