Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts.
Bellingham
Shayne A
SA
Department of Genetics, The University of Melbourne, Victoria, Australia.
Ciccotosto
Giuseppe D
GD
Needham
B Elise
BE
Fodero
Lisa R
LR
White
Anthony R
AR
Masters
Colin L
CL
Cappai
Roberto
R
Camakaris
James
J
D016564:Amyloid beta-Protein Precursor / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology; D003300:Copper / Q000378:metabolism*; D003301:Copper Radioisotopes; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D015870:Gene Expression; D006706:Homeostasis / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009474:Neurons / Q000166:cytology / Q000378:metabolism*
D016564:Amyloid beta-Protein Precursor; C492952:Aplp2 protein, mouse; D003301:Copper Radioisotopes; D003300:Copper