Kappa opioids inhibit physiologically identified medullary pain modulating neurons and reduce morphine antinociception.
Meng
I D
ID
Department of Neurology, University of California, San Francisco, California, USA. imeng@une.edu
Johansen
J P
JP
Harasawa
I
I
Fields
H L
HL
D000200:Action Potentials / Q000187:drug effects; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D044482:Benzeneacetamides / Q000494:pharmacology; D004347:Drug Interactions; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology* / Q000503:physiopathology; D008845:Microinjections / Q000379:methods; D009020:Morphine / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000187:drug effects; D010812:Physical Stimulation / Q000379:methods; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017473:Receptors, Opioid, kappa / Q000819:agonists / Q000502:physiology*
D000701:Analgesics, Opioid; D044482:Benzeneacetamides; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; D009020:Morphine; C045444:U 69593