Electron spin resonance spectroscopy reveals alpha-phenyl-N-tert-butylnitrone spin-traps free radicals in rat striatum and prevents haloperidol-induced vacuous chewing movements in the rat model of human tardive dyskinesia.
Rogoza
Raina M
RM
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5.
Fairfax
David F
DF
Henry
Paul
P
N-Marandi
Sevil
S
Khan
Rao F
RF
Gupta
Suresh K
SK
Mishra
Ram K
RK
D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal; D001665:Binding Sites; D003342:Corpus Striatum / Q000187:drug effects*; D003497:Cyclic N-Oxides; D004195:Disease Models, Animal; D018491:Dopamine Agonists / Q000494:pharmacology; D004347:Drug Interactions; D004409:Dyskinesia, Drug-Induced / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D004578:Electron Spin Resonance Spectroscopy; D006220:Haloperidol / Q000633:toxicity; D006801:Humans; D008297:Male; D008409:Mastication / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D009069:Movement Disorders / Q000209:etiology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009589:Nitrogen Oxides / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000502:physiology
D014150:Antipsychotic Agents; D003497:Cyclic N-Oxides; D018491:Dopamine Agonists; D018696:Neuroprotective Agents; D009589:Nitrogen Oxides; D017382:Reactive Oxygen Species; D017448:Receptors, Dopamine D2; C029217:phenyl-N-tert-butylnitrone; D006220:Haloperidol; D001058:Apomorphine