title: Chemoenzymatic synthesis and high-throughput screening of an aminoglycoside-polyamine library: identification of high-affinity displacers and DNA-binding ligands.
authors.affiliation: Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, New York 12180, USA.
authors.forename: Kaushal
authors.initials: K
authors.lastname: Rege
authors.forename: Shanghui
authors.initials: S
authors.lastname: Hu
authors.forename: James A
authors.initials: JA
authors.lastname: Moore
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Dordick
authors.forename: Steven M
authors.initials: SM
authors.lastname: Cramer
mesh_terms: D000617:Aminoglycosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D002412:Cations; D002852:Chromatography, Ion Exchange / Q000379:methods*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D045304:Cytochromes c / Q000737:chemistry / Q000302:isolation & purification; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005601:Framycetin; D007612:Kanamycin / Q000031:analogs & derivatives / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism; D011073:Polyamines / Q000737:chemistry* / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000617:Aminoglycosides; D002412:Cations; D008024:Ligands; D011073:Polyamines; D011506:Proteins; D005601:Framycetin; D007612:Kanamycin; C488396:neamine; D045304:Cytochromes c; D004247:DNA; D009113:Muramidase