title: Unmet need: what justifies the search for a new antidepressant?
authors.affiliation: University of Michigan, Department of Psychiatry, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, USA. gredenj@umich.edu
authors.forename: John F
authors.initials: JF
authors.lastname: Greden
mesh_terms: D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001284:Atrophy; D002908:Chronic Disease; D003866:Depressive Disorder / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology; D004345:Drug Industry; D004351:Drug Resistance; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D010349:Patient Compliance; D012008:Recurrence; D012107:Research Design; D013678:Technology, Pharmaceutical / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents