Pharmacokinetics and tumor targeting of 131I-labeled F(ab')2 fragments of the chimeric monoclonal antibody G250: preclinical and clinical pilot studies.
Brouwers
Adrienne
A
Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands.
Mulders
Peter
P
Oosterwijk
Egbert
E
Buijs
Wilhelmina
W
Corstens
Frans
F
Boerman
Otto
O
Oyen
Wim
W
D000328:Adult; D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging*; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D010865:Pilot Projects; D011786:Quality Control; D016719:Radioimmunodetection
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes