Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle.
Sakano
Katsuhisa
K
Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 5148507, Japan.
Oikawa
Shinji
S
Hiraku
Yusuke
Y
Kawanishi
Shosuke
S
D000080242:8-Hydroxy-2'-Deoxyguanosine; D002614:Chelating Agents / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism*; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008550:Melatonin / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects
D002614:Chelating Agents; D016166:Free Radical Scavengers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; C427203:calf thymus DNA; D006861:Hydrogen Peroxide; D009251:NADPH-Ferrihemoprotein Reductase; D003849:Deoxyguanosine; D008550:Melatonin; C012365:6-hydroxymelatonin