title: Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.
authors.affiliation: Department of Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, USA. malamam@wyeth.com
authors.forename: Michael S
authors.initials: MS
authors.lastname: Malamas
authors.forename: Eric S
authors.initials: ES
authors.lastname: Manas
authors.forename: Robert E
authors.initials: RE
authors.lastname: McDevitt
authors.forename: Iwan
authors.initials: I
authors.lastname: Gunawan
authors.forename: Zhang B
authors.initials: ZB
authors.lastname: Xu
authors.forename: Michael D
authors.initials: MD
authors.lastname: Collini
authors.forename: Chris P
authors.initials: CP
authors.lastname: Miller
authors.forename: Tam
authors.initials: T
authors.lastname: Dinh
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Henderson
authors.forename: James C
authors.initials: JC
authors.lastname: Keith
authors.forename: Heather A
authors.initials: HA
authors.lastname: Harris
mesh_terms: D000726:Androgen Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D030801:Animals, Genetically Modified; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D001831:Body Temperature / Q000187:drug effects; D001851:Bone Diseases, Metabolic / Q000517:prevention & control; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D015195:Drug Design; D047629:Estrogen Receptor beta; D005260:Female; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D008958:Models, Molecular; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000819:agonists* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D000726:Androgen Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal; D047629:Estrogen Receptor beta; D015796:HLA-B27 Antigen; D007555:Isoxazoles; D010636:Phenols; D011960:Receptors, Estrogen