The preischemic combination of the sodium-hydrogen exchanger inhibitor cariporide and the adenosine agonist AMP579 acts additively to reduce porcine myocardial infarct size.
Kristo
Gentian
G
Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40536-0084, USA.
Yoshimura
Yukihiro
Y
Ferraris
Suellen P
SP
Jahania
Salik A
SA
Mentzer
Robert M
RM
Lasley
Robert D
RD
D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006146:Guanidines / Q000008:administration & dosage* / Q000494:pharmacology; D007093:Imidazoles / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D009203:Myocardial Infarction / Q000276:immunology / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000276:immunology / Q000517:prevention & control*; D018375:Neutrophil Activation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D058906:Purinergic P1 Receptor Agonists; D011725:Pyridines / Q000008:administration & dosage* / Q000494:pharmacology; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors; D013450:Sulfones / Q000008:administration & dosage* / Q000494:pharmacology; D013552:Swine
C113971:4-(7-((2-3-chloro-2-thienyl)-1-methyl-propylamino)-3H-imidazo(4,5-b)pyridyl-3-yl)cyclopentane carboxamide; D002316:Cardiotonic Agents; D006146:Guanidines; D007093:Imidazoles; D058906:Purinergic P1 Receptor Agonists; D011725:Pyridines; D017923:Sodium-Hydrogen Exchangers; D013450:Sulfones; C093373:cariporide