title: In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
authors.affiliation: Department of Exploratory Neurobiology, Global Pharmaceuticals Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6125, USA. art.a.hancock@abbott.com
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Hancock
authors.forename: Marilyn S
authors.initials: MS
authors.lastname: Diehl
authors.forename: Ramin
authors.initials: R
authors.lastname: Faghih
authors.forename: Eugene N
authors.initials: EN
authors.lastname: Bush
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Krueger
authors.forename: Gopala
authors.initials: G
authors.lastname: Krishna
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Miller
authors.forename: Denise M
authors.initials: DM
authors.lastname: Wilcox
authors.forename: Phong
authors.initials: P
authors.lastname: Nguyen
authors.forename: John K
authors.initials: JK
authors.lastname: Pratt
authors.forename: Marlon D
authors.initials: MD
authors.lastname: Cowart
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: Peer B
authors.initials: PB
authors.lastname: Jacobson
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004195:Disease Models, Animal; D015195:Drug Design; D006633:Histamine Antagonists / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D015162:Micronucleus Tests; D015394:Molecular Structure; D009570:Nitriles / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D011869:Radioligand Assay; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D013329:Structure-Activity Relationship; D015431:Weight Loss / Q000187:drug effects
chemical_list: C496814:4'-(3-((3R)-3-(dimethylamino)-1-pyrrolidinyl)-propoxy)-3',5'-difluoro-1,1'-biphenyl-4-carbonitrile; C496813:4'-(3-((3R)-3-(dimethylamino)-1-pyrrolidinyl)propoxy)-3'-fluoro-1,1'-biphenyl-4-carbonitrile; C493218:4'-(3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy)-biphenyl-4-carbonitrile; D019440:Anti-Obesity Agents; D001713:Biphenyl Compounds; D006633:Histamine Antagonists; D009570:Nitriles; D011759:Pyrrolidines; D018100:Receptors, Histamine H3