title: Effect of the Met344His mutation on the conformational dynamics of bovine beta-1,4-galactosyltransferase: crystal structure of the Met344His mutant in complex with chitobiose.
authors.affiliation: Structural Glycobiology Section, Laboratory of Experimental and Computational Biology, SAIC-Frederick, Inc., Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: Boopathy
authors.initials: B
authors.lastname: Ramakrishnan
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Boeggeman
authors.forename: Pradman K
authors.initials: PK
authors.lastname: Qasba
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism; D000818:Animals; D002236:Carbohydrate Conformation; D002384:Catalysis; D002417:Cattle; D003460:Crystallization; D018360:Crystallography, X-Ray; D004187:Disaccharides / Q000737:chemistry* / Q000378:metabolism; D006586:Hexanes / Q000737:chemistry; D006639:Histidine / Q000235:genetics*; D008274:Magnesium / Q000737:chemistry; D008345:Manganese / Q000737:chemistry; D008715:Methionine / Q000235:genetics*; D009005:Monosaccharides / Q000737:chemistry; D016297:Mutagenesis, Site-Directed; D009237:N-Acetyllactosamine Synthase / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014443:Tyrosine / Q000378:metabolism; D014531:Uridine Diphosphate Galactose / Q000737:chemistry
chemical_list: D004187:Disaccharides; D006586:Hexanes; D009005:Monosaccharides; D014531:Uridine Diphosphate Galactose; D014443:Tyrosine; D008345:Manganese; D006639:Histidine; C032438:chitobiose; D008715:Methionine; D009237:N-Acetyllactosamine Synthase; D008274:Magnesium; D000117:Acetylglucosamine