Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors.
Barnett
Stanley F
SF
Department of Cancer Research, Merck and Company, Sumneytown Pike, West Point, PA 19454, USA. stan_barnett@merck.com
Defeo-Jones
Deborah
D
Fu
Sheng
S
Hancock
Paula J
PJ
Haskell
Kathleen M
KM
Jones
Raymond E
RE
Kahana
Jason A
JA
Kral
Astrid M
AM
Leander
Karen
K
Lee
Ling L
LL
Malinowski
John
J
McAvoy
Elizabeth M
EM
Nahas
Debbie D
DD
Robinson
Ronald G
RG
Huber
Hans E
HE
D064413:3-Phosphoinositide-Dependent Protein Kinases; D000255:Adenosine Triphosphate / Q000378:metabolism; D051017:Apoptosis Regulatory Proteins; D001596:Benzylamines / Q000494:pharmacology; D001667:Binding, Competitive; D001798:Blood Proteins / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D002277:Carcinoma / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D003001:Cloning, Molecular; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006574:Heterocyclic Compounds, 2-Ring / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000494:pharmacology; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D010750:Phosphoproteins / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D010766:Phosphorylation / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D011810:Quinoxalines / Q000494:pharmacology; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology
C501520:Akt-I-1 compound; C501521:Akt-I-1,2 compound; D051017:Apoptosis Regulatory Proteins; D001596:Benzylamines; D001798:Blood Proteins; D004791:Enzyme Inhibitors; D006574:Heterocyclic Compounds, 2-Ring; D007527:Isoenzymes; D008562:Membrane Glycoproteins; D010455:Peptides; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D011810:Quinoxalines; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; C039077:platelet protein P47; D000255:Adenosine Triphosphate; D064413:3-Phosphoinositide-Dependent Protein Kinases; C494918:AKT1 protein, human; C494921:AKT2 protein, human; C578562:PDPK1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D020169:Caspases