The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.
Cassera
María B
MB
Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, Brazil.
Gozzo
Fabio C
FC
D'Alexandri
Fabio L
FL
Merino
Emilio F
EF
del Portillo
Hernando A
HA
Peres
Valnice J
VJ
Almeida
Igor C
IC
Eberlin
Marcos N
MN
Wunderlich
Gerhard
G
Wiesner
Jochen
J
Jomaa
Hassan
H
Kimura
Emilia A
EA
Katzin
Alejandro M
AM
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D004286:Dolichols / Q000096:biosynthesis; D004896:Erythritol / Q000031:analogs & derivatives* / Q000378:metabolism*; D004912:Erythrocytes / Q000469:parasitology; D005578:Fosfomycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D017125:Genes, Protozoan; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D015394:Molecular Structure; D010428:Pentosephosphates / Q000096:biosynthesis; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000096:biosynthesis; D021241:Spectrometry, Mass, Electrospray Ionization; D013403:Sugar Phosphates / Q000378:metabolism*; D014451:Ubiquinone / Q000096:biosynthesis
C109460:1-deoxylulose 5-phosphate; C114232:2-C-methylerythritol 4-phosphate; D000962:Antimalarials; D004286:Dolichols; D010428:Pentosephosphates; D013403:Sugar Phosphates; D014451:Ubiquinone; D005578:Fosfomycin; C024640:fosmidomycin; D011732:Pyridoxal Phosphate; D004896:Erythritol; C024593:pyridoxine 5-phosphate