Alpha-1-acid glycoprotein directly affects the pharmacokinetics and the analgesic effect of methadone in the rat beyond protein binding.
Rodriguez
Monica
M
Department of Pharmacology, Faculty of Medicine, University of the Basque Country, Leioa s/n, Vizcaya 48940, Spain.
Ortega
Ignacio
I
Soengas
Itziar
I
Leal
Nerea
N
Suarez
Elena
E
Calvo
Rosario
R
Lukas
John C
JC
D000701:Analgesics, Opioid / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D008297:Male; D008691:Methadone / Q000493:pharmacokinetics* / Q000494:pharmacology; D009961:Orosomucoid / Q000378:metabolism*; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000701:Analgesics, Opioid; D009961:Orosomucoid; D008691:Methadone