title: The development of a modified human IFN-alpha2b linked to the Fc portion of human IgG1 as a novel potential therapeutic for the treatment of hepatitis C virus infection.
authors.affiliation: Biovation Ltd., Babraham, Cambridge, UK. tim.jones@biovation.co.uk
authors.forename: Tim D
authors.initials: TD
authors.lastname: Jones
authors.forename: Marian
authors.initials: M
authors.lastname: Hanlon
authors.forename: Beverley J
authors.initials: BJ
authors.lastname: Smith
authors.forename: Charles T
authors.initials: CT
authors.lastname: Heise
authors.forename: Prakash D
authors.initials: PD
authors.lastname: Nayee
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Sanders
authors.forename: Anita
authors.initials: A
authors.lastname: Hamilton
authors.forename: Clive
authors.initials: C
authors.lastname: Sweet
authors.forename: Esther
authors.initials: E
authors.lastname: Unitt
authors.forename: Graeme
authors.initials: G
authors.lastname: Alexander
authors.forename: Kin-Ming
authors.initials: KM
authors.lastname: Lo
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Gillies
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Carr
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Baker
mesh_terms: D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000737:chemistry* / Q000627:therapeutic use; D002460:Cell Line; D018984:Epitopes, T-Lymphocyte / Q000032:analysis; D016174:Hepacivirus / Q000187:drug effects / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D007128:Immunoglobulin Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000235:genetics* / Q000276:immunology; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000737:chemistry / Q000235:genetics* / Q000627:therapeutic use; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics; D017354:Point Mutation; D011993:Recombinant Fusion Proteins / Q000276:immunology; D011994:Recombinant Proteins
chemical_list: D000998:Antiviral Agents; D018984:Epitopes, T-Lymphocyte; D007141:Immunoglobulin Fc Fragments; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010455:Peptides; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins