title: SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa.
authors.affiliation: Bristol-Myers Squibb Company, PO Box 5400, Princeton, NJ 08543-5400, USA. joanne.smallheer@bms.com
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Smallheer
authors.forename: Richard S
authors.initials: RS
authors.lastname: Alexander
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
authors.forename: Shuaige
authors.initials: S
authors.lastname: Wang
authors.forename: Suanne
authors.initials: S
authors.lastname: Nakajima
authors.forename: Karen A
authors.initials: KA
authors.lastname: Rossi
authors.forename: Angela
authors.initials: A
authors.lastname: Smallwood
authors.forename: Frank
authors.initials: F
authors.lastname: Barbera
authors.forename: Debra
authors.initials: D
authors.lastname: Burdick
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Luettgen
authors.forename: Robert M
authors.initials: RM
authors.lastname: Knabb
authors.forename: Ruth R
authors.initials: RR
authors.lastname: Wexler
authors.forename: Prabhakar K
authors.initials: PK
authors.lastname: Jadhav
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001665:Binding Sites; D018360:Crystallography, X-Ray; D015949:Factor IXa / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D015951:Factor Xa / Q000737:chemistry*; D065427:Factor Xa Inhibitors; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; D065427:Factor Xa Inhibitors; D011720:Pyrazoles; D015949:Factor IXa; D015951:Factor Xa