Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2.
Seasholtz
Tammy M
TM
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0636, USA.
Radeff-Huang
Julie
J
Sagi
Sarah A
SA
Matteo
Rosalia
R
Weems
Jessica M
JM
Cohen
Annemarie Stoudt
AS
Feramisco
James R
JR
Brown
Joan Heller
JH
D001254:Astrocytoma / Q000188:drug therapy / Q000378:metabolism*; D045744:Cell Line, Tumor; D048429:Cell Size / Q000187:drug effects / Q000502:physiology; D003599:Cytoskeleton / Q000187:drug effects / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000378:metabolism; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000378:metabolism; D006801:Humans; D008246:Lysophospholipids / Q000494:pharmacology*; D008845:Microinjections; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D017434:Protein Structure, Tertiary / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013917:Thrombin / Q000494:pharmacology; D010738:Type C Phospholipases / Q000187:drug effects / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000187:drug effects / Q000378:metabolism*
D008246:Lysophospholipids; D019269:Phosphatidylinositol 4,5-Diphosphate; D004247:DNA; D010738:Type C Phospholipases; D013917:Thrombin; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D043802:GTP-Binding Protein alpha Subunits, Gq-G11; D020830:rac1 GTP-Binding Protein; D020741:rho GTP-Binding Proteins; C032881:lysophosphatidic acid