The effect of cholate on solubilisation and permeability of simple and protein-loaded phosphatidylcholine/sodium cholate mixed aggregates designed to mediate transdermal delivery of macromolecules.
Simões
S I
SI
UNFAB, Departamento de Biotecnologia, INETI, Lisboa, Portugal, EU.
Marques
C M
CM
Cruz
M E M
ME
Cevc
G
G
Martins
M B F
MB
D000279:Administration, Cutaneous; D020355:Cholates / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D046911:Macromolecular Substances / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D010539:Permeability / Q000187:drug effects; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D020358:Sodium Cholate / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility / Q000187:drug effects
D020355:Cholates; D046911:Macromolecular Substances; D010713:Phosphatidylcholines; D011506:Proteins; D020358:Sodium Cholate