title: Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma.
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine, USA.
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Gould
authors.forename: Laura
authors.initials: L
authors.lastname: Miceli-Libby
authors.forename: Olga V
authors.initials: OV
authors.lastname: Savinova
authors.forename: Mario
authors.initials: M
authors.lastname: Torrado
authors.forename: Stanislav I
authors.initials: SI
authors.lastname: Tomarev
authors.forename: Richard S
authors.initials: RS
authors.lastname: Smith
authors.forename: Simon W M
authors.initials: SW
authors.lastname: John
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000494:pharmacology; D000328:Adult; D000818:Animals; D003598:Cytoskeletal Proteins; D005123:Eye / Q000033:anatomy & histology; D005136:Eye Proteins / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D005902:Glaucoma, Open-Angle / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009900:Optic Nerve / Q000033:anatomy & histology / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism; D014129:Trabecular Meshwork / Q000166:cytology / Q000378:metabolism; D000099179:Myocilin
chemical_list: D000305:Adrenal Cortex Hormones; D003598:Cytoskeletal Proteins; D005136:Eye Proteins; D006023:Glycoproteins; D000099179:Myocilin