Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays.
Zhu
Zhengrong
Z
Bristol-Myers Squibb Company, Wallingford, CT 06492, USA. zhengrong.zhu@bms.com
Kim
Sean
S
Chen
Taosheng
T
Lin
Jun-Hsiang
JH
Bell
Aneka
A
Bryson
James
J
Dubaquie
Yves
Y
Yan
Ning
N
Yanchunas
Joseph
J
Xie
Dianlin
D
Stoffel
Robert
R
Sinz
Michael
M
Dickinson
Kenneth
K
D002478:Cells, Cultured; D003470:Culture Media; D008024:Ligands; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000378:metabolism; D000077297:Pregnane X Receptor; D011485:Protein Binding; D011869:Radioligand Assay / Q000379:methods*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D012044:Regression Analysis; D015203:Reproducibility of Results; D015533:Transcriptional Activation
D003470:Culture Media; D008024:Ligands; D004364:Pharmaceutical Preparations; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid