Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option.
Leenders
William P J
WP
Department of Pathology, University Medical Centre St. Radboud, Nijmegen, the Netherlands. w.leenders@pathol.umcn.nl
Küsters
Benno
B
Verrijp
Kiek
K
Maass
Cathy
C
Wesseling
Pieter
P
Heerschap
Arend
A
Ruiter
Dirk
D
Ryan
Andy
A
de Waal
Robert
R
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D045744:Cell Line, Tumor; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic; D016376:Oligonucleotides, Antisense / Q000737:chemistry; D010641:Phenotype; D010880:Piperidines / Q000494:pharmacology; D010919:Placebos; D011799:Quinazolines / Q000494:pharmacology; D012313:RNA / Q000378:metabolism; D014162:Transfection; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D016376:Oligonucleotides, Antisense; D010880:Piperidines; D010919:Placebos; D011799:Quinazolines; D042461:Vascular Endothelial Growth Factor A; D012313:RNA; C452423:vandetanib