title: Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity.
authors.affiliation: Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Donghui
authors.initials: D
authors.lastname: Yu
authors.forename: Ehsan
authors.initials: E
authors.lastname: Khan
authors.forename: Md Abdul
authors.initials: MA
authors.lastname: Khaleque
authors.forename: James
authors.initials: J
authors.lastname: Lee
authors.forename: Gary
authors.initials: G
authors.lastname: Laco
authors.forename: Glenda
authors.initials: G
authors.lastname: Kohlhagen
authors.forename: Surender
authors.initials: S
authors.lastname: Kharbanda
authors.forename: Yung-Chi
authors.initials: YC
authors.lastname: Cheng
authors.forename: Yves
authors.initials: Y
authors.lastname: Pommier
authors.forename: Ajit
authors.initials: A
authors.lastname: Bharti
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002166:Camptothecin / Q000494:pharmacology*; D002467:Cell Nucleus / Q000201:enzymology; D002478:Cells, Cultured; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004351:Drug Resistance; D004789:Enzyme Activation / Q000528:radiation effects; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010766:Phosphorylation; D016315:Proto-Oncogene Proteins c-abl / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D059004:Topoisomerase I Inhibitors; D018909:src Homology Domains
chemical_list: D059004:Topoisomerase I Inhibitors; D016315:Proto-Oncogene Proteins c-abl; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin