Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.
Copp
Jeremy
J
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0359, USA.
Wiley
Sandra
S
Ward
Manus W
MW
van der Geer
Peter
P
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D053148:Caspase 3; D020169:Caspases / Q000187:drug effects / Q000378:metabolism*; D002522:Chlorocebus aethiops; D045304:Cytochromes c / Q000187:drug effects / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology; D015151:Immunoblotting; D047468:Immunoprecipitation; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D020928:Mitogen-Activated Protein Kinases / Q000187:drug effects / Q000378:metabolism; D009997:Osmotic Pressure / Q000187:drug effects; D017978:Receptors, Growth Factor / Q000378:metabolism*; D012462:Saline Solution, Hypertonic; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014709:Vero Cells; D018631:ras Proteins / Q000187:drug effects / Q000378:metabolism
D006133:Growth Substances; D017978:Receptors, Growth Factor; D012462:Saline Solution, Hypertonic; D045304:Cytochromes c; D020928:Mitogen-Activated Protein Kinases; D053148:Caspase 3; D020169:Caspases; D018631:ras Proteins