Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group.
Cai
Sui Xiong
SX
Maxim Pharmaceuticals, 6650 Nancy Ridge Drive, San Diego, CA 92121, USA. scai@maxim.com
Guan
Lufeng
L
Jia
Shaojuan
S
Wang
Yan
Y
Yang
Wu
W
Tseng
Ben
B
Drewe
John
J
D000590:Amino Acid Chloromethyl Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D015996:Survival Rate
C500087:2,4-di-Cl-Cbz-Val-Asp-fmk; D000590:Amino Acid Chloromethyl Ketones; D061945:Caspase Inhibitors; D004151:Dipeptides; D007659:Ketones; D011480:Protease Inhibitors; C484771:benzyloxycarbonyl-valyl-aspartic acid fluoromethyl ketone; C505407:CASP3 protein, human; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases