Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.
Afaq
Farrukh
F
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA.
Saleem
Mohammad
M
Krueger
Christian G
CG
Reed
Jess D
JD
Mukhtar
Hasan
H
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000287:Administration, Topical; D000818:Animals; D000872:Anthocyanins / Q000627:therapeutic use*; D002273:Carcinogens / Q000633:toxicity; D051546:Cyclooxygenase 2; D004487:Edema / Q000517:prevention & control; D004817:Epidermis / Q000201:enzymology; D005260:Female; D005638:Fruit / Q000737:chemistry; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000627:therapeutic use*; D006965:Hyperplasia / Q000517:prevention & control; D051550:I-kappa B Kinase; D007527:Isoenzymes / Q000378:metabolism; D029561:Lythraceae / Q000737:chemistry*; D051379:Mice; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D000872:Anthocyanins; D002273:Carcinogens; D047348:Hydrolyzable Tannins; D007527:Isoenzymes; D016328:NF-kappa B; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D017346:Protein Serine-Threonine Kinases; C496564:Chuk protein, mouse; D051550:I-kappa B Kinase; C496562:Ikbkb protein, mouse; C496566:Ikbke protein, mouse; D020928:Mitogen-Activated Protein Kinases; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate