title: Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin K.
authors.affiliation: Department of Medicinal Chemistry, Discovery Research Biology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. francis.x.tavares@gsk.com
authors.forename: Francis X
authors.initials: FX
authors.lastname: Tavares
authors.forename: David N
authors.initials: DN
authors.lastname: Deaton
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Miller
authors.forename: Larry R
authors.initials: LR
authors.lastname: Miller
authors.forename: Lois L
authors.initials: LL
authors.lastname: Wright
authors.forename: Hui-Qiang
authors.initials: HQ
authors.lastname: Zhou
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry; D056657:Cathepsin K; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D002219:Carbamates; D003503:Cyclobutanes; D003517:Cyclopentanes; D007659:Ketones; D011720:Pyrazoles; D002403:Cathepsins; D056657:Cathepsin K