title: Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
authors.affiliation: Alzheimer Research Unit, Massachusetts General Hospital, 114 16th St, Charlestown, Massachusetts 02129, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Lleó
authors.forename: Oksana
authors.initials: O
authors.lastname: Berezovska
authors.forename: Lauren
authors.initials: L
authors.lastname: Herl
authors.forename: Susan
authors.initials: S
authors.lastname: Raju
authors.forename: Amy
authors.initials: A
authors.lastname: Deng
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Bacskai
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Frosch
authors.forename: Michael
authors.initials: M
authors.lastname: Irizarry
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
mesh_terms: D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016282:Aspartic Acid Endopeptidases; D016466:CHO Cells; D002352:Carrier Proteins / Q000378:metabolism*; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D010450:Endopeptidases / Q000378:metabolism*; D031541:Fluorescence Resonance Energy Transfer; D008565:Membrane Proteins / Q000737:chemistry*; D051379:Mice; D008822:Mice, Transgenic; D008958:Models, Molecular; D010446:Peptide Fragments / Q000378:metabolism*; D053764:Presenilin-1; D058255:Protease Nexins; D011487:Protein Conformation / Q000187:drug effects; D011956:Receptors, Cell Surface
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002352:Carrier Proteins; D008565:Membrane Proteins; D010446:Peptide Fragments; D053764:Presenilin-1; D058255:Protease Nexins; D011956:Receptors, Cell Surface; C086839:amyloid beta-protein (17-42); D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse