title: Alpha-1-acid glycoprotein directly affects the pharmacokinetics and the analgesic effect of methadone in the rat beyond protein binding.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of the Basque Country, Leioa s/n, Vizcaya 48940, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Ignacio
authors.initials: I
authors.lastname: Ortega
authors.forename: Itziar
authors.initials: I
authors.lastname: Soengas
authors.forename: Nerea
authors.initials: N
authors.lastname: Leal
authors.forename: Elena
authors.initials: E
authors.lastname: Suarez
authors.forename: Rosario
authors.initials: R
authors.lastname: Calvo
authors.forename: John C
authors.initials: JC
authors.lastname: Lukas
mesh_terms: D000701:Analgesics, Opioid / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D008297:Male; D008691:Methadone / Q000493:pharmacokinetics* / Q000494:pharmacology; D009961:Orosomucoid / Q000378:metabolism*; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000701:Analgesics, Opioid; D009961:Orosomucoid; D008691:Methadone