Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-L-tryptophanate protect human serum albumin against heat and oxidative stress.
Anraku
Makoto
M
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
Tsurusaki
Yasufumi
Y
Watanabe
Hiroshi
H
Maruyama
Toru
T
Kragh-Hansen
Ulrich
U
Otagiri
Masaki
M
D002152:Calorimetry, Differential Scanning; D002210:Caprylates; D002942:Circular Dichroism; D004355:Drug Stability; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012709:Serum Albumin / Q000737:chemistry* / Q000302:isolation & purification; D014364:Tryptophan / Q000031:analogs & derivatives*
D002210:Caprylates; D008024:Ligands; D012709:Serum Albumin; C006392:N-acetyltryptophan; D014364:Tryptophan; C031492:octanoic acid