Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant.
Randolph
G P
GP
CV/CNS Biological Research and Discovery Technologies, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Simon
J S
JS
Arreaza
M G
MG
Qiu
P
P
Lachowicz
J E
JE
Duffy
R A
RA
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000187:drug effects / Q000235:genetics*; D006639:Histidine / Q000235:genetics; D006801:Humans; D064729:Neurokinin-1 Receptor Antagonists; D010446:Peptide Fragments / Q000494:pharmacology; D020641:Polymorphism, Single Nucleotide / Q000187:drug effects / Q000235:genetics*; D011485:Protein Binding / Q000187:drug effects / Q000235:genetics; D018040:Receptors, Neurokinin-1 / Q000819:agonists / Q000235:genetics*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D014443:Tyrosine / Q000235:genetics
D064729:Neurokinin-1 Receptor Antagonists; D010446:Peptide Fragments; D018040:Receptors, Neurokinin-1; C068032:GR 73632; D013373:Substance P; D014443:Tyrosine; D006639:Histidine