Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
Terzioglu
Nalan
N
Istanbul University, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 34452 Istanbul, Turkey.
van Rijn
Richard M
RM
Bakker
Remko A
RA
De Esch
Iwan J P
IJ
Leurs
Rob
R
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001667:Binding, Competitive; D002460:Cell Line; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors*; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; C418607:HRH4 protein, human; D006634:Histamine H1 Antagonists; D007211:Indoles; D008024:Ligands; D010879:Piperazines; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4