Synthesis and structure-activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands.
Van Dort
Marcian E
ME
Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109-0552, USA. mvandort@girindus.com
Jung
Yong-Woon
YW
D000818:Animals; D001667:Binding, Competitive; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D008024:Ligands; D008297:Male; D009570:Nitriles / Q000138:chemical synthesis / Q000494:pharmacology; D011467:Prostate / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism*; D013329:Structure-Activity Relationship
D006827:Hydantoins; D007093:Imidazoles; D007457:Iodine Radioisotopes; D008024:Ligands; D009570:Nitriles; D011944:Receptors, Androgen; C086458:RU 58841; C086459:RU 59063