title: Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell.
authors.affiliation: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors.forename: Deepali K
authors.initials: DK
authors.lastname: Hattangadi
authors.forename: Gerald A
authors.initials: GA
authors.lastname: DeMasters
authors.forename: Teneille D
authors.initials: TD
authors.lastname: Walker
authors.forename: Kara R
authors.initials: KR
authors.lastname: Jones
authors.forename: Xu
authors.initials: X
authors.lastname: Di
authors.forename: Irene F
authors.initials: IF
authors.lastname: Newsham
authors.forename: David A
authors.initials: DA
authors.lastname: Gewirtz
mesh_terms: D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D001943:Breast Neoplasms / Q000473:pathology; D053148:Caspase 3; D020169:Caspases / Q000502:physiology*; D016922:Cellular Senescence / Q000187:drug effects* / Q000502:physiology; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000096:biosynthesis; D004249:DNA Damage / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D016159:Tumor Suppressor Protein p53; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases; D008727:Methotrexate