Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.
Breslin
Henry J
HJ
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh and McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, USA. HBreslin@prdus.jnj.com
Miskowski
Tamara A
TA
Rafferty
Bryan M
BM
Coutinho
Santosh V
SV
Palmer
Jeffrey M
JM
Wallace
Nathaniel H
NH
Schneider
Craig R
CR
Kimball
Edward S
ES
Zhang
Sui-Po
SP
Li
Jian
J
Colburn
Raymond W
RW
Stone
Dennis J
DJ
Martinez
Rebecca P
RP
He
Wei
W
D000009:Abdominal Muscles / Q000187:drug effects / Q000502:physiology; D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D005769:Gastrointestinal Motility / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009119:Muscle Contraction / Q000187:drug effects; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists*; D017465:Receptors, Opioid, delta / Q000819:agonists; D017450:Receptors, Opioid, mu / Q000819:agonists; D013329:Structure-Activity Relationship
D000700:Analgesics; D007093:Imidazoles; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu