Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway.
Inoue
Akiko
A
Department of Pediatrics, Osaka Medical College, Takatsuki 569-8686, Japan.
Muranaka
Shikibu
S
Fujita
Hirofumi
H
Kanno
Tomoko
T
Tamai
Hiroshi
H
Utsumi
Kozo
K
D000077584:2-Methoxyestradiol; D000111:Acetylcysteine / Q000494:pharmacology; D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D051023:BH3 Interacting Domain Death Agonist Protein; D002352:Carrier Proteins / Q000502:physiology; D020169:Caspases / Q000502:physiology; D002867:Chromones / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology; D016572:Cyclosporine / Q000494:pharmacology; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D045304:Cytochromes c / Q000502:physiology; D053938:DNA Fragmentation / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects; D004008:Diclofenac / Q000494:pharmacology*; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D018922:HL-60 Cells / Q000187:drug effects*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D009025:Morpholines / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt; D017382:Reactive Oxygen Species; D015398:Signal Transduction / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors
D000590:Amino Acid Chloromethyl Ketones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D051023:BH3 Interacting Domain Death Agonist Protein; C494814:BID protein, human; D002352:Carrier Proteins; D002867:Chromones; D015853:Cysteine Proteinase Inhibitors; D004273:DNA, Neoplasm; D004791:Enzyme Inhibitors; D009025:Morpholines; D009842:Oligopeptides; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D017382:Reactive Oxygen Species; C401206:acetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehyde; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; D004008:Diclofenac; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D004958:Estradiol; D000077584:2-Methoxyestradiol; D016572:Cyclosporine; D045304:Cytochromes c; D000242:Cyclic AMP; D013482:Superoxide Dismutase; C494918:AKT1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D020169:Caspases; D000111:Acetylcysteine