Synthesis of alkylated deoxynojirimycin and 1,5-dideoxy-1,5-iminoxylitol analogues: polar side-chain modification, sulfonium and selenonium heteroatom variants, conformational analysis, and evaluation as glycosidase inhibitors.
Szczepina
Monica G
MG
Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
Johnston
Blair D
BD
Yuan
Yue
Y
Svensson
Birte
B
Pinto
B Mario
BM
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000478:Alkylation; D001234:Aspergillus niger / Q000201:enzymology; D002240:Carbohydrate Sequence; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005087:Glucan 1,4-alpha-Glucosidase / Q000037:antagonists & inhibitors; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013452:Sulfonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014993:Xylitol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D004791:Enzyme Inhibitors; D016566:Organoselenium Compounds; D013452:Sulfonium Compounds; D017485:1-Deoxynojirimycin; D006026:Glycoside Hydrolases; D005087:Glucan 1,4-alpha-Glucosidase; D014993:Xylitol