Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
Wang
Yanhua
Y
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Zhao
Rongbao
R
Goldman
I David
ID
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001692:Biological Transport; D015152:Blotting, Northern; D002352:Carrier Proteins / Q000737:chemistry*; D002460:Cell Line; D045744:Cell Line, Tumor; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000737:chemistry; D005493:Folic Acid Antagonists / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology*; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D007700:Kinetics; D026901:Membrane Transport Proteins / Q000737:chemistry*; D008727:Methotrexate / Q000494:pharmacology; D000068437:Pemetrexed; D020033:Protein Isoforms; D011799:Quinazolines / Q000494:pharmacology; D012313:RNA / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry*; D058978:Reduced Folate Carrier Protein; D013876:Thiophenes / Q000494:pharmacology; D013997:Time Factors; D014162:Transfection; D016597:Trimetrexate / Q000494:pharmacology
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists; D005971:Glutamates; D007477:Ions; D026901:Membrane Transport Proteins; D020033:Protein Isoforms; D011799:Quinazolines; D011956:Receptors, Cell Surface; D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human; D013876:Thiophenes; C094299:ZD 9331; D000068437:Pemetrexed; D006147:Guanine; D012313:RNA; D005492:Folic Acid; C068874:raltitrexed; D016597:Trimetrexate; D008727:Methotrexate