title: Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
authors.affiliation: Chemical and Screening Sciences and Oncology Research, Wyeth Research, Pearl River, NY 10965, USA. ay2122@columbia.edu
authors.forename: Ayako
authors.initials: A
authors.lastname: Yamashita
authors.forename: Emily B
authors.initials: EB
authors.lastname: Norton
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Kaplan
authors.forename: Chuan
authors.initials: C
authors.lastname: Niu
authors.forename: Frank
authors.initials: F
authors.lastname: Loganzo
authors.forename: Richard
authors.initials: R
authors.lastname: Hernandez
authors.forename: Carl F
authors.initials: CF
authors.lastname: Beyer
authors.forename: Tami
authors.initials: T
authors.lastname: Annable
authors.forename: Sylvia
authors.initials: S
authors.lastname: Musto
authors.forename: Carolyn
authors.initials: C
authors.lastname: Discafani
authors.forename: Arie
authors.initials: A
authors.lastname: Zask
authors.forename: Semiramis
authors.initials: S
authors.lastname: Ayral-Kaloustian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001704:Biopolymers; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007624:KB Cells; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008819:Mice, Nude; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry*; D050257:Tubulin Modulators; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D001704:Biopolymers; C473896:HTI-286; D009842:Oligopeptides; D014404:Tubulin; D050257:Tubulin Modulators; C467070:hemiasterlin