title: Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation.
authors.affiliation: MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Fox
authors.forename: David S
authors.initials: DS
authors.lastname: Barber
authors.forename: Bhupinder
authors.initials: B
authors.lastname: Singh
authors.forename: Birgit
authors.initials: B
authors.lastname: Zucker
authors.forename: Mary K
authors.initials: MK
authors.lastname: Swindell
authors.forename: Fran
authors.initials: F
authors.lastname: Norflus
authors.forename: Rodica
authors.initials: R
authors.lastname: Buzescu
authors.forename: Raman
authors.initials: R
authors.lastname: Chopra
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ferrante
authors.forename: Aleksey
authors.initials: A
authors.lastname: Kazantsev
authors.forename: Steven M
authors.initials: SM
authors.lastname: Hersch
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D019328:Buthionine Sulfoximine / Q000494:pharmacology; D003538:Cystamine / Q000494:pharmacology*; D003545:Cysteine / Q000378:metabolism*; D019610:Cytoprotection / Q000187:drug effects; D004195:Disease Models, Animal; D018450:Disease Progression; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D005978:Glutathione / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D016716:PC12 Cells; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D051381:Rats
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D010455:Peptides; C097188:polyglutamine; D019328:Buthionine Sulfoximine; D005978:Glutathione; D003545:Cysteine; D003538:Cystamine