Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.
Reigan
Philip
P
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Gbaj
Abdul
A
Chinje
Edwin
E
Stratford
Ian J
IJ
Douglas
Kenneth T
KT
Freeman
Sally
S
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D004926:Escherichia coli / Q000201:enzymology; D006801:Humans; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D014969:Xanthine Oxidase / Q000737:chemistry*
D000970:Antineoplastic Agents; D011355:Prodrugs; D011743:Pyrimidines; D011758:Pyrroles; D011759:Pyrrolidines; D014969:Xanthine Oxidase; D013939:Thymidine Phosphorylase