Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.
Malamas
Michael S
MS
Department of Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, USA. malamam@wyeth.com
Manas
Eric S
ES
McDevitt
Robert E
RE
Gunawan
Iwan
I
Xu
Zhang B
ZB
Collini
Michael D
MD
Miller
Chris P
CP
Dinh
Tam
T
Henderson
Ruth A
RA
Keith
James C
JC
Harris
Heather A
HA
D000726:Androgen Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D030801:Animals, Genetically Modified; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D001831:Body Temperature / Q000187:drug effects; D001851:Bone Diseases, Metabolic / Q000517:prevention & control; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D015195:Drug Design; D047629:Estrogen Receptor beta; D005260:Female; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D008958:Models, Molecular; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000819:agonists* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
D000726:Androgen Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal; D047629:Estrogen Receptor beta; D015796:HLA-B27 Antigen; D007555:Isoxazoles; D010636:Phenols; D011960:Receptors, Estrogen