Effects and mechanisms of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats.
Wei
Yao Hong
YH
Zhejiang Respiratory Drugs Research Laboratory of State Food and Drugs Administration of China, School of Medicine, Zhejiang University, Hangzhou 310031, China. yhgwei@hotmail.com
Li
Yue
Y
Qiang
Chen Ji
CJ
D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001835:Body Weight / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002681:China; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D005620:Freund's Adjuvant / Q000008:administration & dosage / Q000009:adverse effects; D007279:Injections, Subcutaneous; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000494:pharmacology* / Q000627:therapeutic use; D016753:Interleukin-10 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007555:Isoxazoles / Q000494:pharmacology / Q000627:therapeutic use; D007719:Knee Joint / Q000187:drug effects / Q000503:physiopathology / Q000648:ultrastructure; D000077339:Leflunomide; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011720:Pyrazoles / Q000008:administration & dosage / Q000493:pharmacokinetics; D011725:Pyridines / Q000008:administration & dosage / Q000493:pharmacokinetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects / Q000502:physiology; D013582:Synovial Fluid / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
C104334:FR 167653; D007375:Interleukin-1; D007555:Isoxazoles; D011720:Pyrazoles; D011725:Pyridines; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D005620:Freund's Adjuvant; D000077339:Leflunomide