title: c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.
authors.affiliation: Beatson Institute for Cancer Research, Bearsden, UK. annmac@scripps.edu
authors.forename: Ann
authors.initials: A
authors.lastname: MacLaren
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Black
authors.forename: William
authors.initials: W
authors.lastname: Clark
authors.forename: David A F
authors.initials: DA
authors.lastname: Gillespie
mesh_terms: D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins; D018929:Cell Culture Techniques / Q000379:methods; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D002478:Cells, Cultured; D016922:Cellular Senescence; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D017930:Genes, Reporter; D006657:Histones / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017434:Protein Structure, Tertiary; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism*; D011839:Radiation, Ionizing; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D025521:Tumor Suppressor Proteins
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D006657:Histones; D016877:Oxidants; D016755:Proto-Oncogene Proteins c-jun; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; C475961:gamma-H2AX protein, mouse; D006861:Hydrogen Peroxide; D064007:Ataxia Telangiectasia Mutated Proteins; C576325:Atm protein, mouse; D017346:Protein Serine-Threonine Kinases; D010100:Oxygen