Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats.
Pitkänen
Asla
A
A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, P.O. Box 1627, FIN-70 211 Kuopio, Finland. asla.pitkanen@uku.fi
Narkilahti
Susanna
S
Bezvenyuk
Zinayida
Z
Haapalinna
Antti
A
Nissinen
Jari
J
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000502:physiology; D003975:Diazepam / Q000008:administration & dosage / Q000627:therapeutic use; D018450:Disease Progression; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004594:Electrophysiology; D004644:Emotions / Q000187:drug effects; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000517:prevention & control* / Q000523:psychology; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015918:Infusion Pumps, Implantable; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology; D007858:Learning / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013226:Status Epilepticus / Q000473:pathology / Q000517:prevention & control
D000316:Adrenergic alpha-Agonists; D000927:Anticonvulsants; D007093:Imidazoles; C050701:atipamezole; D003975:Diazepam