title: Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism.
authors.affiliation: Department of Neurology, Baylor College of Medicine, One Baylor Plaza, NB 302, Houston, TX, 77030, USA.
authors.forename: Weihua
authors.initials: W
authors.lastname: Zhao
authors.forename: Wenjie
authors.initials: W
authors.lastname: Xie
authors.forename: Weidong
authors.initials: W
authors.lastname: Le
authors.forename: David R
authors.initials: DR
authors.lastname: Beers
authors.forename: Yi
authors.initials: Y
authors.lastname: He
authors.forename: Jenny S
authors.initials: JS
authors.lastname: Henkel
authors.forename: Ericka P
authors.initials: EP
authors.lastname: Simpson
authors.forename: Albert A
authors.initials: AA
authors.lastname: Yen
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiao
authors.forename: Stanley H
authors.initials: SH
authors.lastname: Appel
mesh_terms: D027322:Amino Acid Transport System X-AG / Q000037:antagonists & inhibitors / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002374:Catalase / Q000378:metabolism / Q000494:pharmacology; D002450:Cell Communication / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D002478:Cells, Cultured; D018920:Coculture Techniques; D005609:Free Radicals / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism* / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology; D017628:Microglia / Q000378:metabolism*; D009046:Motor Neurons / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D018384:Oxidative Stress / Q000502:physiology*; D030421:Peroxynitrous Acid / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology
chemical_list: D027322:Amino Acid Transport System X-AG; D005609:Free Radicals; D018091:Receptors, AMPA; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D018698:Glutamic Acid; D002374:Catalase; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D005978:Glutathione