Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors.
Nakamura
Toshio
T
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-Cho 1-Chome, Kita-ku, Saitama-Shi, Saitama 331-9530, Japan. toshio.nakamura@po.rd.taisho.co.jp
Ishii
Takaaki
T
Miyata
Noriyuki
N
Taniguchi
Kazuo
K
Tomishima
Yasumitsu
Y
Ueki
Tomokazu
T
Sato
Masakazu
M
D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism / Q000648:ultrastructure; D008861:Microsomes / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship
D065607:Cytochrome P-450 Enzyme Inhibitors; D006893:Hydroxyeicosatetraenoic Acids; D007093:Imidazoles; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid