Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription.
Wang
B
B
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA.
Ma
L
L
Tao
X
X
Lipsky
P E
PE
D000818:Animals; D018929:Cell Culture Techniques; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004852:Epoxy Compounds; D015870:Gene Expression; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis* / Q000235:genetics; D052247:Nitric Oxide Synthase Type II; D050811:Octamer Transcription Factor-1; D010616:Phenanthrenes / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D029757:Tripterygium
D004268:DNA-Binding Proteins; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D004852:Epoxy Compounds; D050811:Octamer Transcription Factor-1; D010616:Phenanthrenes; D010936:Plant Extracts; C494166:Pou2f1 protein, mouse; D014157:Transcription Factors; C001899:triptolide; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse