title: Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.
authors.affiliation: Division of Biological Chemistry & Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, Scotland, UK.
authors.forename: David
authors.initials: D
authors.lastname: Komander
authors.forename: Alison
authors.initials: A
authors.lastname: Fairservice
authors.forename: Maria
authors.initials: M
authors.lastname: Deak
authors.forename: Gursant S
authors.initials: GS
authors.lastname: Kular
authors.forename: Alan R
authors.initials: AR
authors.lastname: Prescott
authors.forename: C
authors.initials: C
authors.lastname: Peter Downes
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Safrany
authors.forename: Dario R
authors.initials: DR
authors.lastname: Alessi
authors.forename: Daan M F
authors.initials: DM
authors.lastname: van Aalten
mesh_terms: D064413:3-Phosphoinositide-Dependent Protein Kinases; D000595:Amino Acid Sequence; D001665:Binding Sites; D001667:Binding, Competitive; D002460:Cell Line; D018360:Crystallography, X-Ray; D003600:Cytosol / Q000737:chemistry / Q000378:metabolism; D031541:Fluorescence Resonance Energy Transfer; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007295:Inositol Phosphates / Q000378:metabolism*; D008024:Ligands; D050356:Lipid Metabolism; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D009154:Mutation; D010716:Phosphatidylinositols / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry
chemical_list: D007295:Inositol Phosphates; D008024:Ligands; D010716:Phosphatidylinositols; D011993:Recombinant Fusion Proteins; D014867:Water; D005982:Glutathione Transferase; D064413:3-Phosphoinositide-Dependent Protein Kinases; C578562:PDPK1 protein, human; D017346:Protein Serine-Threonine Kinases