Combinatorial synthesis of benztropine libraries and their evaluation as monoamine transporter inhibitors.
Pedersen
Hanne
H
Department of Chemistry, University of Aarhus, Langelandsgade 140, DK-8000, Aarhus C.
Sinning
Steffen
S
Bulow
Anne
A
Wiborg
Ove
O
Falborg
Lise
L
Bols
Mikael
M
D001590:Benztropine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002460:Cell Line; D002478:Cells, Cultured; D020650:Combinatorial Chemistry Techniques; D004298:Dopamine / Q000493:pharmacokinetics; D050483:Dopamine Plasma Membrane Transport Proteins / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D015394:Molecular Structure; D009638:Norepinephrine / Q000493:pharmacokinetics; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000187:drug effects*; D012701:Serotonin / Q000493:pharmacokinetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000187:drug effects*
D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D050484:Norepinephrine Plasma Membrane Transport Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D001590:Benztropine; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine