Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain.
Kortagere
Sandhya
S
Department of Physiology & Biophysics, Weill Medical College of Cornell University, New York, New York, USA.
Gmeiner
Peter
P
Weinstein
Harel
H
Schetz
John A
JA
D000818:Animals; D001665:Binding Sites; D019556:COS Cells; D002522:Chlorocebus aethiops; D016297:Mutagenesis, Site-Directed; D010879:Piperazines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D050638:Receptors, Dopamine D4; D011994:Recombinant Proteins / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
C493601:Drd4 protein, rat; D010879:Piperazines; D010880:Piperidines; D017448:Receptors, Dopamine D2; D011994:Recombinant Proteins; D050638:Receptors, Dopamine D4