Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
Eldrup
Anne B
AB
Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, CA 92008, USA. aeldrup@isisph.com
Prhavc
Marija
M
Brooks
Jennifer
J
Bhat
Balkrishen
B
Prakash
Thazha P
TP
Song
Quanlai
Q
Bera
Sanjib
S
Bhat
Neelima
N
Dande
Prasad
P
Cook
P Dan
PD
Bennett
C Frank
CF
Carroll
Steven S
SS
Ball
Richard G
RG
Bosserman
Michele
M
Burlein
Christine
C
Colwell
Lawrence F
LF
Fay
John F
JF
Flores
Osvaldo A
OA
Getty
Krista
K
LaFemina
Robert L
RL
Leone
Joseph
J
MacCoss
Malcolm
M
McMasters
Daniel R
DR
Tomassini
Joanne E
JE
Von Langen
Derek
D
Wolanski
Bohdan
B
Olsen
David B
DB
D000243:Adenosine Deaminase / Q000737:chemistry; D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D002460:Cell Line; D004355:Drug Stability; D016174:Hepacivirus / Q000235:genetics*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010766:Phosphorylation; D011683:Purine-Nucleoside Phosphorylase / Q000737:chemistry; D012367:RNA, Viral / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D013329:Structure-Activity Relationship
C492972:4-amino-5-fluoro-7H-pyrrolo(2,3-d)pyrimidine ribonucleoside; D000998:Antiviral Agents; D012367:RNA, Viral; D012263:Ribonucleosides; D011683:Purine-Nucleoside Phosphorylase; D000243:Adenosine Deaminase