title: p38 alpha mitogen-activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol-induced acute myocardial injury in rats.
authors.affiliation: Department of Pharmacology and Preclinical Research, Scios Inc., Fremont, CA 94555, USA. li@sciosinc.com
authors.forename: Zhihe
authors.initials: Z
authors.lastname: Li
authors.forename: Thomas-Toan
authors.initials: TT
authors.lastname: Tran
authors.forename: Jing Ying
authors.initials: JY
authors.lastname: Ma
authors.forename: Gilbert
authors.initials: G
authors.lastname: O'Young
authors.forename: Ann M
authors.initials: AM
authors.lastname: Kapoun
authors.forename: Sarvajit
authors.initials: S
authors.lastname: Chakravarty
authors.forename: Sundeep
authors.initials: S
authors.lastname: Dugar
authors.forename: George
authors.initials: G
authors.lastname: Schreiner
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Protter
mesh_terms: D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007545:Isoproterenol; D008297:Male; D048308:Mitogen-Activated Protein Kinase 14 / Q000037:antagonists & inhibitors*; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D009929:Organ Size / Q000187:drug effects; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002316:Cardiotonic Agents; D012333:RNA, Messenger; D048308:Mitogen-Activated Protein Kinase 14; D007545:Isoproterenol