title: Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes.
authors.affiliation: Pharma Research Basel (70/131), F. Hoffmann-LaRoche Ltd., Pharmaceuticals Division, Grenzacherstrasse No. 124, CH 4070 Basel, Switzerland.
authors.forename: Nadège
authors.initials: N
authors.lastname: Blanchard
authors.forename: Lysiane
authors.initials: L
authors.lastname: Richert
authors.forename: Brigitte
authors.initials: B
authors.lastname: Notter
authors.forename: Frederic
authors.initials: F
authors.lastname: Delobel
authors.forename: Pascale
authors.initials: P
authors.lastname: David
authors.forename: Philippe
authors.initials: P
authors.lastname: Coassolo
authors.forename: Thierry
authors.initials: T
authors.lastname: Lavé
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002853:Chromatography, Liquid; D003470:Culture Media / Q000737:chemistry*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D022781:Hepatocytes / Q000201:enzymology / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000201:enzymology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011237:Predictive Value of Tests; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003470:Culture Media; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System