title: Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
authors.affiliation: Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hays
authors.forename: Ivan
authors.initials: I
authors.lastname: Rusyn
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Burns
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Kennett
authors.forename: Jerrold M
authors.initials: JM
authors.lastname: Ward
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Gonzalez
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Peters
mesh_terms: D042962:Acyl-CoA Oxidase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001629:Bezafibrate / Q000378:metabolism* / Q000633:toxicity; D001647:Bile Acids and Salts / Q000378:metabolism; D015152:Blotting, Northern; D018797:Cell Cycle Proteins / Q000187:drug effects / Q000378:metabolism; D002779:Cholestasis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D042926:Cytochrome P-450 CYP4A / Q000187:drug effects / Q000378:metabolism; D045643:DNA Repair Enzymes / Q000187:drug effects / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D047493:PPAR alpha / Q000172:deficiency* / Q000235:genetics; D020025:Peroxisome Proliferators / Q000633:toxicity*; D012333:RNA, Messenger / Q000032:analysis; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors / Q000187:drug effects / Q000378:metabolism; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D042962:Acyl-CoA Oxidase; D001629:Bezafibrate; D001647:Bile Acids and Salts; D018797:Cell Cycle Proteins; D042926:Cytochrome P-450 CYP4A; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins; D047493:PPAR alpha; D020025:Peroxisome Proliferators; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated