title: Cellular G protein-coupled receptor kinase levels regulate sensitivity of the {alpha}2b-adrenergic receptor to undergo agonist-induced down-regulation.
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204-5037, USA.
authors.forename: Aarti N
authors.initials: AN
authors.lastname: Desai
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Standifer
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Eikenburg
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D015153:Blotting, Western; D002460:Cell Line; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D009638:Norepinephrine / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011869:Radioligand Assay; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D014162:Transfection; D051552:beta-Adrenergic Receptor Kinases
chemical_list: C547771:ADRA2B protein, human; D000316:Adrenergic alpha-Agonists; D018341:Receptors, Adrenergic, alpha-2; D017346:Protein Serine-Threonine Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D051552:beta-Adrenergic Receptor Kinases; D009638:Norepinephrine; D004837:Epinephrine