The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors.
Campbell
Erica L
EL
Department of Pharmacology, The University of Sydney, Sydney 2006, NSW, Australia.
Chebib
Mary
M
Johnston
Graham A R
GA
D000818:Animals; D047310:Apigenin / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D004032:Diet; D004347:Drug Interactions; D005419:Flavonoids / Q000494:pharmacology; D019833:Genistein / Q000494:pharmacology; D006801:Humans; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D011994:Recombinant Proteins / Q000187:drug effects / Q000378:metabolism; D014982:Xenopus laevis; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005419:Flavonoids; D011963:Receptors, GABA-A; D011994:Recombinant Proteins; D005680:gamma-Aminobutyric Acid; D047310:Apigenin; D002392:Catechin; C045651:epigallocatechin gallate; D019833:Genistein; D003975:Diazepam