Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.
Wojnowski
Leszek
L
Department of Pharmacology, University Mainz, Obere Zahlbacher Str. 67, D-55101 Mainz, Germany.
Turner
Paul C
PC
Pedersen
Bonnie
B
Hustert
Elisabeth
E
Brockmöller
Jürgen
J
Mendy
Maimuna
M
Whittle
Hilton C
HC
Kirk
Greg
G
Wild
Christopher P
CP
D000293:Adolescent; D000328:Adult; D016604:Aflatoxin B1 / Q000031:analogs & derivatives* / Q000097:blood; D000348:Aflatoxins / Q000097:blood* / Q000633:toxicity; D000368:Aged; D000418:Albumins; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D002648:Child; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005714:Gambia; D015870:Gene Expression; D005787:Gene Frequency; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000378:metabolism; D011110:Polymorphism, Genetic; D012307:Risk Factors
D000348:Aflatoxins; D000418:Albumins; D009153:Mutagens; C098408:aflatoxin-albumin adduct; C006426:aflatoxin B1-2,3-oxide; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D016604:Aflatoxin B1; C104464:CYP3A protein, human; C510164:CYP3A5 protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human