Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity.
Duncan
Robin E
RE
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Fitzgerald Building, 150 College Street, Toronto, Ont., Canada M5S 3E2.
Lau
Dominic
D
El-Sohemy
Ahmed
A
Archer
Michael C
MC
D000080462:Acyclic Monoterpenes; D001943:Breast Neoplasms / Q000473:pathology; D042846:CDC2-CDC28 Kinases / Q000378:metabolism*; D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D051357:Cyclin-Dependent Kinase 2; D004305:Dose-Response Relationship, Drug; D016193:G1 Phase / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D045792:Norisoprenoids / Q000494:pharmacology*; D016196:S Phase / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology*; D013997:Time Factors; D014407:Tumor Cells, Cultured
D000080462:Acyclic Monoterpenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D045792:Norisoprenoids; D013729:Terpenes; C008157:beta-ionone; D006903:Hydroxymethylglutaryl CoA Reductases; D042846:CDC2-CDC28 Kinases; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2; C007836:geraniol