A possibility to predict the absorbability of poorly water-soluble drugs in humans based on rat intestinal permeability assessed by an in vitro chamber method.
Watanabe
Etsushi
E
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan. watanqsf@daiichipharm.co.jp
Takahashi
Masayuki
M
Hayashi
Masahiro
M
D000818:Animals; D015194:Diffusion Chambers, Culture; D006801:Humans; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism*; D011237:Predictive Value of Tests; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility / Q000187:drug effects; D014867:Water / Q000737:chemistry*
D004364:Pharmaceutical Preparations; D014867:Water