Apo and inhibitor complex structures of BACE (beta-secretase).
Patel
Sahil
S
Astex Technology, 436 Cambridge Science Park, Milton Road, CB4 0QA, UK.
Vuillard
Laurent
L
Cleasby
Anne
A
Murray
Christopher W
CW
Yon
Jeff
J
D000588:Amines / Q000737:chemistry* / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001665:Binding Sites; D018360:Crystallography, X-Ray; D015195:Drug Design; D010450:Endopeptidases / Q000737:chemistry* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D006860:Hydrogen Bonding; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D017434:Protein Structure, Tertiary; D013696:Temperature
D000588:Amines; D004791:Enzyme Inhibitors; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse