title: Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Reigan
authors.forename: Abdul
authors.initials: A
authors.lastname: Gbaj
authors.forename: Edwin
authors.initials: E
authors.lastname: Chinje
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Stratford
authors.forename: Kenneth T
authors.initials: KT
authors.lastname: Douglas
authors.forename: Sally
authors.initials: S
authors.lastname: Freeman
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D004926:Escherichia coli / Q000201:enzymology; D006801:Humans; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D014969:Xanthine Oxidase / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs; D011743:Pyrimidines; D011758:Pyrroles; D011759:Pyrrolidines; D014969:Xanthine Oxidase; D013939:Thymidine Phosphorylase