title: Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1.
authors.affiliation: Division of Pulmonary Biology, Children's Hospital Medical Center and Department of Pediatrics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Dong
authors.initials: D
authors.lastname: Yan
authors.forename: Molly
authors.initials: M
authors.lastname: Bruggeman
authors.forename: Hong
authors.initials: H
authors.lastname: Du
authors.forename: Cong
authors.initials: C
authors.lastname: Yan
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004742:Enhancer Elements, Genetic / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D020868:Gene Silencing; D017930:Genes, Reporter; D051548:Histone Acetyltransferases; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007763:Lac Operon; D008156:Luciferases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D008239:Lysine / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D056920:Nuclear Receptor Coactivator 1; D017354:Point Mutation; D011650:Pulmonary Alveoli / Q000166:cytology / Q000378:metabolism; D037701:Pulmonary Surfactant-Associated Protein B / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D020545:Respiratory Mucosa / Q000166:cytology / Q000378:metabolism; D017384:Sequence Deletion; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C000614412:NKX2-1 protein, human; C000614414:Nkx2-1 protein, mouse; D009687:Nuclear Proteins; D037701:Pulmonary Surfactant-Associated Protein B; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D008156:Luciferases; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; C538859:NCOA1 protein, human; C538861:Ncoa1 protein, mouse; D056920:Nuclear Receptor Coactivator 1; D008239:Lysine