Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug.
Al-Saidan
S M
SM
Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, SAFAT, Kuwait.
Krishnaiah
Y S R
YS
Satyanarayana
V
V
Bhaskar
P
P
Karthikeyan
R S
RS
D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D004341:Drug Evaluation / Q000379:methods; D005685:Galactans / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008351:Mannans / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008790:Metoprolol / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008956:Models, Chemical; D053149:Plant Gums; D012995:Solubility / Q000187:drug effects; D013608:Tablets, Enteric-Coated
D003692:Delayed-Action Preparations; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D013608:Tablets, Enteric-Coated; C007894:guar gum; D008790:Metoprolol