Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.
Ostacolo
C
C
Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Via D. Montesano 49, 80181 Naples, Italy.
Marra
F
F
Laneri
S
S
Sacchi
A
A
Nicoli
S
S
Padula
C
C
Santi
P
P
D000409:Alanine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004304:Dosage Forms; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004423:Ear / Q000473:pathology*; D004950:Esterases / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism; D006868:Hydrolysis; D008099:Liver / Q000201:enzymology; D010539:Permeability / Q000187:drug effects; D011355:Prodrugs / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis; D011817:Rabbits; D012867:Skin / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D013552:Swine; D014018:Tissue Distribution; D024505:Tocopherols; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D004304:Dosage Forms; D011355:Prodrugs; D004950:Esterases; D024502:alpha-Tocopherol; D000409:Alanine; D024505:Tocopherols; D011761:Pyrrolidonecarboxylic Acid; D005998:Glycine