Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1.
Yang
Li
L
Division of Pulmonary Biology, Children's Hospital Medical Center and Department of Pediatrics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.
Yan
Dong
D
Bruggeman
Molly
M
Du
Hong
H
Yan
Cong
C
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004742:Enhancer Elements, Genetic / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D020868:Gene Silencing; D017930:Genes, Reporter; D051548:Histone Acetyltransferases; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007763:Lac Operon; D008156:Luciferases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D008239:Lysine / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D056920:Nuclear Receptor Coactivator 1; D017354:Point Mutation; D011650:Pulmonary Alveoli / Q000166:cytology / Q000378:metabolism; D037701:Pulmonary Surfactant-Associated Protein B / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D020545:Respiratory Mucosa / Q000166:cytology / Q000378:metabolism; D017384:Sequence Deletion; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C000614412:NKX2-1 protein, human; C000614414:Nkx2-1 protein, mouse; D009687:Nuclear Proteins; D037701:Pulmonary Surfactant-Associated Protein B; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D008156:Luciferases; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; C538859:NCOA1 protein, human; C538861:Ncoa1 protein, mouse; D056920:Nuclear Receptor Coactivator 1; D008239:Lysine