Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.
Villani
Maria Grazia
MG
Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy.
Appierto
Valentina
V
Cavadini
Elena
E
Valsecchi
Manuela
M
Sonnino
Sandro
S
Curley
Robert W
RW
Formelli
Franca
F
D016588:Anticarcinogenic Agents / Q000097:blood*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003577:Cytochrome P-450 Enzyme System / Q000097:blood* / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D017313:Fenretinide / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics*; D005822:Genetic Vectors; D006801:Humans; D015151:Immunoblotting; D013058:Mass Spectrometry; D010051:Ovarian Neoplasms / Q000097:blood* / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism; D000072516:Retinoic Acid 4-Hydroxylase; D012177:Retinol-Binding Proteins / Q000096:biosynthesis*; D054840:Retinol-Binding Proteins, Cellular; D054839:Retinol-Binding Proteins, Plasma; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D013997:Time Factors; D014162:Transfection; D014212:Tretinoin / Q000494:pharmacology; D015854:Up-Regulation
C494898:4-oxofenretinide; D016588:Anticarcinogenic Agents; D018076:DNA, Complementary; C518456:RBP1 protein, human; D012333:RNA, Messenger; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular; D054839:Retinol-Binding Proteins, Plasma; D017313:Fenretinide; D014212:Tretinoin; D003577:Cytochrome P-450 Enzyme System; D000072516:Retinoic Acid 4-Hydroxylase; D010100:Oxygen