Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.
Vaglini
Francesca
F
Department of Neuroscience, Section of Pharmacology, University of Pisa, Pisa, Italy. f.vaglini@drugs.med.unipi.it
Pardini
Carla
C
Viaggi
Cristina
C
Bartoli
Cristina
C
Dinucci
Dinuccio
D
Corsini
Giovanni Umberto
GU
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000378:metabolism; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000498:Allyl Compounds / Q000494:pharmacology; D000818:Animals; D015153:Blotting, Western; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics / Q000378:metabolism*; D065691:Cytochrome P-450 CYP2E1 Inhibitors; D004195:Disease Models, Animal; D004050:Ditiocarb / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017551:Microdialysis; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000201:enzymology* / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013440:Sulfides / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis
D000498:Allyl Compounds; D065691:Cytochrome P-450 CYP2E1 Inhibitors; D004791:Enzyme Inhibitors; D013440:Sulfides; D015102:3,4-Dihydroxyphenylacetic Acid; C038491:allyl sulfide; D004050:Ditiocarb; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D019392:Cytochrome P-450 CYP2E1; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine