alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW 264.7 cells.
Demarco
Vincent G
VG
Department of Child Health, University of Missouri, Columbia, MO 65211, USA.
Scumpia
Philip O
PO
Bosanquet
James P
JP
Skimming
Jeffrey W
JW
D000818:Animals; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism; D004731:Endotoxins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D000076249:Heat Shock Transcription Factors; D018869:Heat-Shock Response / Q000502:physiology*; D006358:Hot Temperature; D020672:I-kappa B Proteins / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000096:biosynthesis* / Q000378:metabolism; D008063:Thioctic Acid / Q000494:pharmacology*; D051996:Transcription Factor RelA; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; D004731:Endotoxins; D018840:HSP70 Heat-Shock Proteins; D000076249:Heat Shock Transcription Factors; C490017:Hsf1 protein, mouse; D020672:I-kappa B Proteins; D008070:Lipopolysaccharides; D016328:NF-kappa B; D051996:Transcription Factor RelA; D014157:Transcription Factors; D009569:Nitric Oxide; D008063:Thioctic Acid; D019001:Nitric Oxide Synthase