title: U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.
authors.affiliation: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Fukuoka, Japan.
authors.forename: Shigetsugu
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Takumi
authors.initials: T
authors.lastname: Kamura
authors.forename: Miyuki
authors.initials: M
authors.lastname: Murayama
authors.forename: Du-Hua
authors.initials: DH
authors.lastname: Chui
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Planel
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Takahashi
authors.forename: Keiichi I
authors.initials: KI
authors.lastname: Nakayama
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takashima
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000235:genetics; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000235:genetics; D002522:Chlorocebus aethiops; D003546:Cysteine Endopeptidases / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000378:metabolism; D016297:Mutagenesis, Site-Directed; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D011485:Protein Binding / Q000235:genetics / Q000502:physiology; D034622:RNA Interference; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics / Q000502:physiology*; D017384:Sequence Deletion; D024801:Tauopathies / Q000378:metabolism* / Q000473:pathology; D014162:Transfection; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; C494371:HSPA8 protein, human; C494372:Hspa8 protein, mouse; D009097:Multienzyme Complexes; D011993:Recombinant Fusion Proteins; D025801:Ubiquitin; D016875:tau Proteins; C492951:Stub1 protein, mouse; C471292:Ube4b protein, mouse; D044767:Ubiquitin-Protein Ligases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex