A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides.
Siddiqui
Maqbool A
MA
Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD 21702, USA.
Hughes
Stephen H
SH
Boyer
Paul L
PL
Mitsuya
Hiroaki
H
Van
Que N
QN
George
Clifford
C
Sarafinanos
Stefan G
SG
Marquez
Victor E
VE
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D002460:Cell Line; D018360:Crystallography, X-Ray; D004279:DNA, Viral / Q000737:chemistry; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000737:chemistry; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D010755:Organophosphates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010766:Phosphorylation; D010770:Phosphotransferases / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D016047:Zalcitabine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
C492964:6-amino-3-(5-ethynyl-5-(hydroxymethyl)oxolan-2-yl)-3-hydroxypyrimidin-2-one; D000480:Alkynes; D019380:Anti-HIV Agents; D004279:DNA, Viral; D015224:Dideoxynucleosides; D010755:Organophosphates; D011355:Prodrugs; D016047:Zalcitabine; D010770:Phosphotransferases; D054303:HIV Reverse Transcriptase