Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol.
Besumbes
Oscar
O
Departament de Bioquímica i Biologia Molecular, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-7, 08028 Barcelona, Spain.
Sauret-Güeto
Susanna
S
Phillips
Michael A
MA
Imperial
Santiago
S
Rodríguez-Concepción
Manuel
M
Boronat
Albert
A
D000475:Alkenes / Q000378:metabolism*; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D004224:Diterpenes / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D007535:Isomerases / Q000235:genetics / Q000378:metabolism*; D017239:Paclitaxel / Q000096:biosynthesis*; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D030821:Plants, Genetically Modified; D011106:Polyisoprenyl Phosphates / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D020946:Taxus / Q000201:enzymology / Q000235:genetics*
D000475:Alkenes; D004224:Diterpenes; D010940:Plant Proteins; D011106:Polyisoprenyl Phosphates; D011994:Recombinant Proteins; C093125:taxa-4(5),11(12)diene; D007535:Isomerases; C095926:taxa-4(5),11(12)-diene synthase; C002963:geranylgeranyl pyrophosphate; D017239:Paclitaxel