title: Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
authors.affiliation: Membrane Trafficking Laboratory, CME-VIB04, Gasthuisberg-KU Leuven, 3000 Leuven, Belgium.
authors.forename: Cary
authors.initials: C
authors.lastname: Esselens
authors.forename: Viola
authors.initials: V
authors.lastname: Oorschot
authors.forename: Veerle
authors.initials: V
authors.lastname: Baert
authors.forename: Tim
authors.initials: T
authors.lastname: Raemaekers
authors.forename: Kurt
authors.initials: K
authors.lastname: Spittaels
authors.forename: Lutgarde
authors.initials: L
authors.lastname: Serneels
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.forename: Paul
authors.initials: P
authors.lastname: Saftig
authors.forename: Bart
authors.initials: B
authors.lastname: De Strooper
authors.forename: Judith
authors.initials: J
authors.lastname: Klumperman
authors.forename: Wim
authors.initials: W
authors.lastname: Annaert
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001343:Autophagy / Q000502:physiology*; D000071192:Autophagy-Related Protein 12; D002402:Cathepsin D / Q000235:genetics; D015815:Cell Adhesion Molecules; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D011992:Endosomes / Q000235:genetics / Q000378:metabolism; D006367:HeLa Cells; D006624:Hippocampus / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008247:Lysosomes / Q000235:genetics / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D046529:Microscopy, Electron, Transmission; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000235:genetics / Q000378:metabolism; D053764:Presenilin-1; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D025841:Small Ubiquitin-Related Modifier Proteins; D014617:Vacuoles / Q000378:metabolism / Q000648:ultrastructure
chemical_list: C466624:ATG12 protein, human; D000199:Actins; D016564:Amyloid beta-Protein Precursor; D000071192:Autophagy-Related Protein 12; D015815:Cell Adhesion Molecules; C086747:ICAM5 protein, human; C504585:Icam5 protein, mouse; C477012:MAP1LC3A protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C508853:PSEN1 protein, human; D019269:Phosphatidylinositol 4,5-Diphosphate; D053764:Presenilin-1; D011506:Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse; D002402:Cathepsin D