Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity.
Yu
Donghui
D
Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Khan
Ehsan
E
Khaleque
Md Abdul
MA
Lee
James
J
Laco
Gary
G
Kohlhagen
Glenda
G
Kharbanda
Surender
S
Cheng
Yung-Chi
YC
Pommier
Yves
Y
Bharti
Ajit
A
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002166:Camptothecin / Q000494:pharmacology*; D002467:Cell Nucleus / Q000201:enzymology; D002478:Cells, Cultured; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004351:Drug Resistance; D004789:Enzyme Activation / Q000528:radiation effects; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010766:Phosphorylation; D016315:Proto-Oncogene Proteins c-abl / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D059004:Topoisomerase I Inhibitors; D018909:src Homology Domains
D059004:Topoisomerase I Inhibitors; D016315:Proto-Oncogene Proteins c-abl; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin