title: Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts.
authors.affiliation: Division of Rheumatology and Immunology, Dept. of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. bogatkev@musc.edu
authors.forename: Galina S
authors.initials: GS
authors.lastname: Bogatkevich
authors.forename: Estella
authors.initials: E
authors.lastname: Gustilo
authors.forename: Jim C
authors.initials: JC
authors.lastname: Oates
authors.forename: Carol
authors.initials: C
authors.lastname: Feghali-Bostwick
authors.forename: Russell A
authors.initials: RA
authors.lastname: Harley
authors.forename: Richard M
authors.initials: RM
authors.lastname: Silver
authors.forename: Anna
authors.initials: A
authors.lastname: Ludwicka-Bradley
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000187:drug effects; D018797:Cell Cycle Proteins / Q000378:metabolism; D002470:Cell Survival; D002478:Cells, Cultured; D019938:Cyclin D1 / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004247:DNA / Q000096:biosynthesis*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D053222:Fas Ligand Protein; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000494:pharmacology; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000473:pathology; D010766:Phosphorylation / Q000187:drug effects; D011493:Protein Kinase C / Q000378:metabolism*; D051571:Protein Kinase C-alpha; D051744:Protein Kinase C-epsilon; D044463:Receptor, PAR-1 / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000473:pathology*; D013917:Thrombin / Q000494:pharmacology*
chemical_list: C493956:CDKN1A protein, human; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D007527:Isoenzymes; D008562:Membrane Glycoproteins; D044463:Receptor, PAR-1; D019938:Cyclin D1; D004247:DNA; C496628:PRKCA protein, human; C497255:PRKCE protein, human; D011493:Protein Kinase C; D051571:Protein Kinase C-alpha; D051744:Protein Kinase C-epsilon; D048049:Extracellular Signal-Regulated MAP Kinases; D013917:Thrombin