title: Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.
authors.affiliation: Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. a.c.pearce@bham.ac.uk
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Pearce
authors.forename: Yotis A
authors.initials: YA
authors.lastname: Senis
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Billadeau
authors.forename: Martin
authors.initials: M
authors.lastname: Turner
authors.forename: Steve P
authors.initials: SP
authors.lastname: Watson
authors.forename: Elena
authors.initials: E
authors.lastname: Vigorito
mesh_terms: D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D001792:Blood Platelets / Q000737:chemistry / Q000502:physiology; D018955:CD36 Antigens / Q000737:chemistry / Q000502:physiology; D018797:Cell Cycle Proteins; D003094:Collagen / Q000494:pharmacology*; D004789:Enzyme Activation / Q000502:physiology; D004792:Enzyme Precursors / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D018345:Mice, Knockout; D015513:Oncogene Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D051966:Phospholipase C gamma; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D015539:Platelet Activation / Q000187:drug effects* / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D038981:Receptors, Collagen / Q000737:chemistry / Q000502:physiology; D000072377:Syk Kinase; D010738:Type C Phospholipases / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D018955:CD36 Antigens; D018797:Cell Cycle Proteins; D004792:Enzyme Precursors; D020662:Guanine Nucleotide Exchange Factors; D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D038981:Receptors, Collagen; C496618:VAV1 protein, human; C496621:VAV3 protein, human; C496619:Vav1 protein, mouse; C490565:Vav2 protein, mouse; C496622:Vav3 protein, mouse; D019000:Phosphotyrosine; D003094:Collagen; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000606896:SYK protein, human; D000072377:Syk Kinase; C000606897:Syk protein, mouse; D019061:src-Family Kinases; D010738:Type C Phospholipases; D051966:Phospholipase C gamma