Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
Andrews
Martin J I
MJ
Cyclacel Limited, James Lindsay Place, Dundee, Scotland, UK. mandrews@cyclacel.com
McInnes
Campbell
C
Kontopidis
George
G
Innes
Lorraine
L
Cowan
Angela
A
Plater
Andy
A
Fischer
Peter M
PM
D001665:Binding Sites / Q000187:drug effects; D019295:Computational Biology; D018360:Crystallography, X-Ray; D019925:Cyclin A / Q000737:chemistry; D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000187:drug effects; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011487:Protein Conformation
D019925:Cyclin A; D009097:Multienzyme Complexes; D019151:Peptide Library; D010456:Peptides, Cyclic; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051357:Cyclin-Dependent Kinase 2