Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts.
Bogatkevich
Galina S
GS
Division of Rheumatology and Immunology, Dept. of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. bogatkev@musc.edu
Gustilo
Estella
E
Oates
Jim C
JC
Feghali-Bostwick
Carol
C
Harley
Russell A
RA
Silver
Richard M
RM
Ludwicka-Bradley
Anna
A
D000368:Aged; D017209:Apoptosis / Q000187:drug effects; D018797:Cell Cycle Proteins / Q000378:metabolism; D002470:Cell Survival; D002478:Cells, Cultured; D019938:Cyclin D1 / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004247:DNA / Q000096:biosynthesis*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D053222:Fas Ligand Protein; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000494:pharmacology; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000473:pathology; D010766:Phosphorylation / Q000187:drug effects; D011493:Protein Kinase C / Q000378:metabolism*; D051571:Protein Kinase C-alpha; D051744:Protein Kinase C-epsilon; D044463:Receptor, PAR-1 / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000473:pathology*; D013917:Thrombin / Q000494:pharmacology*
C493956:CDKN1A protein, human; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D007527:Isoenzymes; D008562:Membrane Glycoproteins; D044463:Receptor, PAR-1; D019938:Cyclin D1; D004247:DNA; C496628:PRKCA protein, human; C497255:PRKCE protein, human; D011493:Protein Kinase C; D051571:Protein Kinase C-alpha; D051744:Protein Kinase C-epsilon; D048049:Extracellular Signal-Regulated MAP Kinases; D013917:Thrombin