title: Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line.
authors.affiliation: Gene Targeting Group, Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London W12 ONN, United Kingdom.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Carpenter
authors.forename: Andrew C G
authors.initials: AC
authors.lastname: Porter
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism*; D017209:Apoptosis / Q000235:genetics; D002460:Cell Line; D002467:Cell Nucleus / Q000235:genetics; D002877:Chromosomes, Human / Q000378:metabolism; D004250:DNA Topoisomerases, Type II / Q000235:genetics* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D004318:Doxycycline / Q000494:pharmacology; D017353:Gene Deletion; D005804:Genes, Lethal / Q000235:genetics*; D005816:Genetic Complementation Test; D006801:Humans; D008938:Mitosis; D009154:Mutation / Q000235:genetics*; D010766:Phosphorylation; D011123:Polyploidy; D012694:Serine / Q000235:genetics / Q000378:metabolism; D014443:Tyrosine / Q000235:genetics / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D004268:DNA-Binding Proteins; D014443:Tyrosine; D012694:Serine; D004250:DNA Topoisomerases, Type II; D004318:Doxycycline