title: Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U.K.
authors.forename: Peter
authors.initials: P
authors.lastname: Grundt
authors.forename: Ian A
authors.initials: IA
authors.lastname: Williams
authors.forename: John W
authors.initials: JW
authors.lastname: Lewis
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Husbands
mesh_terms: D001665:Binding Sites; D008958:Models, Molecular; D009292:Narcotic Antagonists / Q000138:chemical synthesis / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009292:Narcotic Antagonists; D010880:Piperidines; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D013764:Tetrahydronaphthalenes