title: Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
authors.affiliation: Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Jiandie
authors.initials: J
authors.lastname: Lin
authors.forename: Pei-Hsuan
authors.initials: PH
authors.lastname: Wu
authors.forename: Paul T
authors.initials: PT
authors.lastname: Tarr
authors.forename: Katrin S
authors.initials: KS
authors.lastname: Lindenberg
authors.forename: Julie
authors.initials: J
authors.lastname: St-Pierre
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Zhang
authors.forename: Vamsi K
authors.initials: VK
authors.lastname: Mootha
authors.forename: Sibylle
authors.initials: S
authors.lastname: Jäger
authors.forename: Claudia R
authors.initials: CR
authors.lastname: Vianna
authors.forename: Richard M
authors.initials: RM
authors.lastname: Reznick
authors.forename: Libin
authors.initials: L
authors.lastname: Cui
authors.forename: Monia
authors.initials: M
authors.lastname: Manieri
authors.forename: Mi X
authors.initials: MX
authors.lastname: Donovan
authors.forename: Zhidan
authors.initials: Z
authors.lastname: Wu
authors.forename: Marcus P
authors.initials: MP
authors.lastname: Cooper
authors.forename: Melina C
authors.initials: MC
authors.lastname: Fan
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Rohas
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Zavacki
authors.forename: Saverio
authors.initials: S
authors.lastname: Cinti
authors.forename: Gerald I
authors.initials: GI
authors.lastname: Shulman
authors.forename: Bradford B
authors.initials: BB
authors.lastname: Lowell
authors.forename: Dimitri
authors.initials: D
authors.lastname: Krainc
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Spiegelman
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D001069:Appetite Regulation / Q000235:genetics; D001480:Basal Ganglia Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000235:genetics / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004734:Energy Metabolism / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D005943:Gluconeogenesis / Q000235:genetics*; D005947:Glucose / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics; D006948:Hyperkinesis / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D015534:Trans-Activators / Q000172:deficiency / Q000235:genetics*; D014157:Transcription Factors; D015854:Up-Regulation / Q000235:genetics
chemical_list: D022782:CCAAT-Enhancer-Binding Protein-beta; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D005947:Glucose