title: Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors.
authors.affiliation: Department of Cancer Research, Merck and Company, Sumneytown Pike, West Point, PA 19454, USA. stan_barnett@merck.com
authors.forename: Stanley F
authors.initials: SF
authors.lastname: Barnett
authors.forename: Deborah
authors.initials: D
authors.lastname: Defeo-Jones
authors.forename: Sheng
authors.initials: S
authors.lastname: Fu
authors.forename: Paula J
authors.initials: PJ
authors.lastname: Hancock
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Haskell
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Jones
authors.forename: Jason A
authors.initials: JA
authors.lastname: Kahana
authors.forename: Astrid M
authors.initials: AM
authors.lastname: Kral
authors.forename: Karen
authors.initials: K
authors.lastname: Leander
authors.forename: Ling L
authors.initials: LL
authors.lastname: Lee
authors.forename: John
authors.initials: J
authors.lastname: Malinowski
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: McAvoy
authors.forename: Debbie D
authors.initials: DD
authors.lastname: Nahas
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Robinson
authors.forename: Hans E
authors.initials: HE
authors.lastname: Huber
mesh_terms: D064413:3-Phosphoinositide-Dependent Protein Kinases; D000255:Adenosine Triphosphate / Q000378:metabolism; D051017:Apoptosis Regulatory Proteins; D001596:Benzylamines / Q000494:pharmacology; D001667:Binding, Competitive; D001798:Blood Proteins / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D002277:Carcinoma / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D003001:Cloning, Molecular; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006574:Heterocyclic Compounds, 2-Ring / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000494:pharmacology; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D010750:Phosphoproteins / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D010766:Phosphorylation / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D011810:Quinoxalines / Q000494:pharmacology; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology
chemical_list: C501520:Akt-I-1 compound; C501521:Akt-I-1,2 compound; D051017:Apoptosis Regulatory Proteins; D001596:Benzylamines; D001798:Blood Proteins; D004791:Enzyme Inhibitors; D006574:Heterocyclic Compounds, 2-Ring; D007527:Isoenzymes; D008562:Membrane Glycoproteins; D010455:Peptides; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D011810:Quinoxalines; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; C039077:platelet protein P47; D000255:Adenosine Triphosphate; D064413:3-Phosphoinositide-Dependent Protein Kinases; C494918:AKT1 protein, human; C494921:AKT2 protein, human; C578562:PDPK1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D020169:Caspases