title: SGS742: the first GABA(B) receptor antagonist in clinical trials.
authors.affiliation: Neuroscience Research, Novartis Pharma AG, WKL-136.5.25, CH-4002 Basel, Switzerland. wolfgang.froestl@pharma.novartis.com
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Froestl
authors.forename: Michela
authors.initials: M
authors.lastname: Gallagher
authors.forename: Helen
authors.initials: H
authors.lastname: Jenkins
authors.forename: Annette
authors.initials: A
authors.lastname: Madrid
authors.forename: Thorsten
authors.initials: T
authors.lastname: Melcher
authors.forename: Sam
authors.initials: S
authors.lastname: Teichman
authors.forename: Cesare G
authors.initials: CG
authors.lastname: Mondadori
authors.forename: Rodney
authors.initials: R
authors.lastname: Pearlman
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D003072:Cognition Disorders / Q000188:drug therapy*; D005260:Female; D018756:GABA Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D058788:GABA-B Receptor Antagonists; D006801:Humans; D008297:Male; D051379:Mice; D009943:Organophosphorus Compounds / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
chemical_list: D018756:GABA Antagonists; D058788:GABA-B Receptor Antagonists; D009943:Organophosphorus Compounds; C079148:(3-aminopropyl)(n-butyl)phosphinic acid