title: Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.
authors.affiliation: Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
authors.forename: Govindarajan
authors.initials: G
authors.lastname: Manikumar
authors.forename: Randy M
authors.initials: RM
authors.lastname: Wadkins
authors.forename: David
authors.initials: D
authors.lastname: Bearss
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Von Hoff
authors.forename: Mansukhlal C
authors.initials: MC
authors.lastname: Wani
authors.forename: Monroe E
authors.initials: ME
authors.lastname: Wall
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007659:Ketones / Q000737:chemistry; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
chemical_list: D000970:Antineoplastic Agents; D007659:Ketones; D059004:Topoisomerase I Inhibitors; D002166:Camptothecin