Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects.
Müllner
Carmen
C
Abteilung Pharmakologie und Toxikologie, Institut für Pharmazie, Universität Innsbruck, Peter-Mayrstrasse 1/I, A-6020 Innsbruck, Austria.
Broos
Ludo A M
LA
van den Maagdenberg
Arn M J M
AM
Striessnig
Jörg
J
D000818:Animals; D020864:Calcium Channels, N-Type / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D006429:Hemiplegia / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D015640:Ion Channel Gating; D020325:Migraine with Aura / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D020125:Mutation, Missense; D009865:Oocytes / Q000378:metabolism; D017354:Point Mutation; D021122:Protein Subunits; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014982:Xenopus laevis
D020864:Calcium Channels, N-Type; D021122:Protein Subunits; D011994:Recombinant Proteins