12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes.
Wang
Hong
H
Department of Neurology, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Li
Jianrong
J
Follett
Pamela L
PL
Zhang
Yumin
Y
Cotanche
Douglas A
DA
Jensen
Frances E
FE
Volpe
Joseph J
JJ
Rosenberg
Paul A
PA
D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000502:physiology*; D016718:Arachidonic Acid / Q000494:pharmacology*; D016923:Cell Death / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D009836:Oligodendroglia / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D016859:Lipoxygenase Inhibitors; D016718:Arachidonic Acid; D001092:Arachidonate 12-Lipoxygenase; D005978:Glutathione