Evaluation of isolated lung perfusion as neoadjuvant therapy of lung metastases using a novel in vivo pig model: II. High-dose cisplatin is well tolerated by the native lung tissue.
Franke
Ulrich F W
UF
Department of Cardiothoracic and Vascular Surgery, Friedrich-Schiller-University Jena, D-07740 Jena, Germany. ulrich.franke@med.uni-jena.de
Wittwer
Thorsten
T
Kaluza
Mirko
M
Albert
Marc
M
Becker
Valentin
V
Roskos
Martin
M
Lessel
Marlene
M
Wahlers
Thorsten
T
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D006979:Hyperthermia, Induced; D008168:Lung / Q000378:metabolism; D008170:Lung Compliance / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D020360:Neoadjuvant Therapy / Q000379:methods; D010984:Platinum / Q000493:pharmacokinetics; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000473:pathology; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects
D000970:Antineoplastic Agents; D010984:Platinum; D002945:Cisplatin