Enhanced acetaminophen toxicity by activation of the pregnane X receptor.
Guo
Grace L
GL
Laboratory of Metabolism, CCR, NCI, NIH, Bethesda, Maryland 20892, USA.
Moffit
Jeff S
JS
Nicol
Christopher J
CJ
Ward
Jerrold M
JM
Aleksunes
Lauren A
LA
Slitt
Angela L
AL
Kliewer
Steven A
SA
Manautou
Jose E
JE
Gonzalez
Frank J
FJ
D000082:Acetaminophen / Q000493:pharmacokinetics / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis; D001711:Biotransformation; D015152:Blotting, Northern; D002851:Chromatography, High Pressure Liquid; D051544:Cytochrome P-450 CYP3A; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis; D000077297:Pregnane X Receptor; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects*; D011987:Receptors, Steroid / Q000187:drug effects*; D013438:Sulfhydryl Compounds / Q000378:metabolism
D018712:Analgesics, Non-Narcotic; D008565:Membrane Proteins; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D013438:Sulfhydryl Compounds; D011285:Pregnenolone Carbonitrile; D000082:Acetaminophen; D001189:Aryl Hydrocarbon Hydroxylases; C496508:Cyp3a11 protein, mouse; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating