EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2.
Oosterhoff
Josien K
JK
Department of Reproduction and Development, Erasmus MC, Rotterdam, Rotterdam, The Netherlands.
Kühne
Liesbeth C
LC
Grootegoed
J Anton
JA
Blok
Leen J
LJ
D000728:Androgens / Q000494:pharmacology; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D051766:Early Growth Response Protein 1; D004705:Endocytosis; D004815:Epidermal Growth Factor / Q000378:metabolism / Q000494:pharmacology*; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000235:genetics / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000728:Androgens; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D017874:Immediate-Early Proteins; D047908:Intracellular Signaling Peptides and Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; C489722:REPS2 protein, human; D012333:RNA, Messenger; D014157:Transcription Factors; D004815:Epidermal Growth Factor; D066246:ErbB Receptors