title: Optimizing the antibacterial activity of a lead structure discovered by "SAR by MS" technology.
authors.affiliation: Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA. e.jeffers@isisph.com
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Jefferson
authors.forename: Punit P
authors.initials: PP
authors.lastname: Seth
authors.forename: Dale E
authors.initials: DE
authors.lastname: Robinson
authors.forename: Dana K
authors.initials: DK
authors.lastname: Winter
authors.forename: Alycia
authors.initials: A
authors.lastname: Miyaji
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Risen
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Osgood
authors.forename: Myra
authors.initials: M
authors.lastname: Bertrand
authors.forename: Eric E
authors.initials: EE
authors.lastname: Swayze
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D013058:Mass Spectrometry; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012338:RNA, Ribosomal, 23S / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D005663:Furans; D010879:Piperazines; D012338:RNA, Ribosomal, 23S