Effect of change in cellular GSH levels on mitochondrial damage and cell viability loss due to mitomycin c in small cell lung cancer cells.
Lee
Chung Soo
CS
Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 156-756, South Korea. leecs@cau.ac.kr
Park
Se Young
SY
Ko
Hyun Hee
HH
Han
Eun Sook
ES
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D018288:Carcinoma, Small Cell; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D045304:Cytochromes c / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D016685:Mitomycin / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D016685:Mitomycin; D045304:Cytochromes c; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases; D005978:Glutathione