Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.
Joseph
Jamie W
JW
Departments of Medicine and Physiology, University of Toronto, Ontario M5S 1A8, Canada.
Koshkin
Vasilij
V
Saleh
Monique C
MC
Sivitz
William I
WI
Zhang
Chen-Yu
CY
Lowell
Bradford B
BB
Chan
Catherine B
CB
Wheeler
Michael B
MB
D000244:Adenosine Diphosphate / Q000737:chemistry; D000255:Adenosine Triphosphate / Q000737:chemistry; D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D015153:Blotting, Western; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005947:Glucose / Q000737:chemistry / Q000378:metabolism; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007473:Ion Channels; D007515:Islets of Langerhans / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D008564:Membrane Potentials; D026901:Membrane Transport Proteins / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000096:biosynthesis* / Q000235:genetics; D009765:Obesity / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D019308:Palmitic Acid / Q000378:metabolism; D010641:Phenotype; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species; D011994:Recombinant Proteins / Q000737:chemistry; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D019076:Transgenes; D014280:Triglycerides / Q000737:chemistry / Q000378:metabolism; D000071246:Uncoupling Protein 2
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species; D011994:Recombinant Proteins; D014280:Triglycerides; C000604390:Ucp2 protein, mouse; D000071246:Uncoupling Protein 2; D019308:Palmitic Acid; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D005947:Glucose; D010100:Oxygen; D002118:Calcium