Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
Li
Qun
Q
Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. qun.li@abbott.com
Wang
Gary T
GT
Li
Tongmei
T
Gwaltney
Stephen L
SL
Woods
Keith W
KW
Claiborne
Akiyo
A
Wang
Xilu
X
Gu
Wendy
W
Cohen
Jerry
J
Stoll
Vincent S
VS
Hutchins
Charles
C
Frost
David
D
Rosenberg
Saul H
SH
Sham
Hing L
HL
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002461:Cell Line, Transformed; D018360:Crystallography, X-Ray; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051231:Farnesyltranstransferase; D011905:Genes, ras; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008958:Models, Molecular; D041681:NIH 3T3 Cells; D015363:Quinolones / Q000737:chemistry; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D004987:Ethers; D007093:Imidazoles; D015363:Quinolones; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase; C402769:tipifarnib