Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively.
Lai
Yurong
Y
Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.
Lee
Eun-Woo
EW
Ton
Carl C
CC
Vijay
Shashi
S
Zhang
Huixia
H
Unadkat
Jashvant D
JD
D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D017124:Conserved Sequence; D004285:Dogs; D005838:Genotype; D049452:Green Fluorescent Proteins / Q000235:genetics; D006151:Guanosine / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000166:cytology; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D014316:Tritium; D014529:Uridine / Q000493:pharmacokinetics
D026901:Membrane Transport Proteins; C065171:cif nucleoside transporter; D014316:Tritium; D006151:Guanosine; D049452:Green Fluorescent Proteins; D014529:Uridine