Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis.
Nomoto
Hiroshi
H
Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
Iigo
Masaaki
M
Hamada
Hiroki
H
Kojima
Shuji
S
Tsuda
Hiroyuki
H
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D001397:Azoxymethane / Q000633:toxicity; D044946:Biflavonoids / Q000494:pharmacology / Q000627:therapeutic use; D002273:Carcinogens / Q000633:toxicity; D053148:Caspase 3; D020169:Caspases / Q000187:drug effects / Q000378:metabolism*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects*; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D007150:Immunohistochemistry; D008297:Male; D044945:Proanthocyanidins / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344
D000975:Antioxidants; D044946:Biflavonoids; D002273:Carcinogens; D044945:Proanthocyanidins; C013221:proanthocyanidin; C479580:procyanidin B2; D002392:Catechin; C045651:epigallocatechin gallate; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; D001397:Azoxymethane