Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugs.
Osborne
Neville N
NN
Nuffield Laboratory of Ophthalmology, Oxford University, Oxford, United Kingdom. neville.osborne@eye.ox.ac.uk <neville.osborne@eye.ox.ac.uk>
Wood
John P M
JP
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D015153:Blotting, Western; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D005136:Eye Proteins / Q000378:metabolism; D051606:G-Protein-Coupled Receptor Kinase 1; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D015227:Lipid Peroxidation / Q000187:drug effects*; D014290:Metipranolol / Q000494:pharmacology*; D020030:Nitric Oxide Donors / Q000633:toxicity*; D009599:Nitroprusside / Q000633:toxicity; D020419:Photoreceptor Cells, Vertebrate / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D005136:Eye Proteins; D020030:Nitric Oxide Donors; D019253:Proto-Oncogene Proteins c-bcl-2; D017392:Thiobarbituric Acid Reactive Substances; D009599:Nitroprusside; D011065:Poly(ADP-ribose) Polymerases; D011494:Protein Kinases; D051606:G-Protein-Coupled Receptor Kinase 1; C496765:Grk1 protein, rat; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; D014290:Metipranolol