Heterogeneous conditions in dissolved oxygen affect N-glycosylation but not productivity of a monoclonal antibody in hybridoma cultures.
Serrato
J Antonio
JA
Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apdo. Postal 510-3, Cuernavaca, Morelos, CP 62250, Mexico.
Palomares
Laura A
LA
Meneses-Acosta
Angélica
A
Ramírez
Octavio T
OT
D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism*; D019149:Bioreactors; D002240:Carbohydrate Sequence / Q000502:physiology; D006031:Glycosylation; D006825:Hybridomas / Q000502:physiology*; D007074:Immunoglobulin G / Q000378:metabolism*; D051379:Mice; D010100:Oxygen / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D010100:Oxygen