title: Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, SAFAT, Kuwait.
authors.forename: S M
authors.initials: SM
authors.lastname: Al-Saidan
authors.forename: Y S R
authors.initials: YS
authors.lastname: Krishnaiah
authors.forename: V
authors.initials: V
authors.lastname: Satyanarayana
authors.forename: P
authors.initials: P
authors.lastname: Bhaskar
authors.forename: R S
authors.initials: RS
authors.lastname: Karthikeyan
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D004341:Drug Evaluation / Q000379:methods; D005685:Galactans / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008351:Mannans / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008790:Metoprolol / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008956:Models, Chemical; D053149:Plant Gums; D012995:Solubility / Q000187:drug effects; D013608:Tablets, Enteric-Coated
chemical_list: D003692:Delayed-Action Preparations; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D013608:Tablets, Enteric-Coated; C007894:guar gum; D008790:Metoprolol