Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones.
Pinkerton
Anthony B
AB
Merck Research Laboratories, MRLSDB2, 3535 General Atomics Court, San Diego, CA 92121, USA. anthony_pinkerton@merck.com
Cube
Rowena V
RV
Hutchinson
John H
JH
Rowe
Blake A
BA
Schaffhauser
Hervé
H
Zhao
Xiumin
X
Daggett
Lorrie P
LP
Vernier
Jean-Michel
JM
D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000494:Allosteric Regulation; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000098:Acetophenones; D018094:Receptors, Metabotropic Glutamate; D013777:Tetrazoles; C108822:metabotropic glutamate receptor 2