Pragmatic target discovery from novel gene to functionally defined drug target: the interleukin-1 story.
Allan
Stuart McRae
SM
School of Biological Science, University of Manchester, United Kingdom.
D000818:Animals; D015195:Drug Design; D015870:Gene Expression; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007375:Interleukin-1 / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009410:Nerve Degeneration / Q000188:drug therapy / Q000209:etiology / Q000235:genetics; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D015398:Signal Transduction; D020521:Stroke / Q000188:drug therapy / Q000209:etiology / Q000235:genetics
D018836:Inflammation Mediators; D007375:Interleukin-1; D017472:Receptors, Interleukin-1