title: Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors.
authors.affiliation: EA 3247 Laboratoire de Chimie Organique, UFR des Sciences Pharmaceutiques, Université de Tours, 31 Avenue Monge, 37200 Tours, France.
authors.forename: David
authors.initials: D
authors.lastname: Alagille
authors.forename: Bruno
authors.initials: B
authors.lastname: Pfeiffer
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Scalbert
authors.forename: Gilles
authors.initials: G
authors.lastname: Ferry
authors.forename: Jean A
authors.initials: JA
authors.lastname: Boutin
authors.forename: Pierre
authors.initials: P
authors.lastname: Renard
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Viaud-Massuard
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D053818:Chymases; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014162:Transfection
chemical_list: D004791:Enzyme Inhibitors; D006827:Hydantoins; D007211:Indoles; D011994:Recombinant Proteins; D015842:Serine Proteinase Inhibitors; D044005:Tetrahydroisoquinolines; D012697:Serine Endopeptidases; D053818:Chymases