title: Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells.
authors.affiliation: John Hughes Bennett Laboratory, Division of Oncology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.
authors.forename: Melany
authors.initials: M
authors.lastname: Jackson
authors.forename: Anna
authors.initials: A
authors.lastname: Krassowska
authors.forename: Nick
authors.initials: N
authors.lastname: Gilbert
authors.forename: Timothy
authors.initials: T
authors.lastname: Chevassut
authors.forename: Lesley
authors.initials: L
authors.lastname: Forrester
authors.forename: John
authors.initials: J
authors.lastname: Ansell
authors.forename: Bernard
authors.initials: B
authors.lastname: Ramsahoye
mesh_terms: D000107:Acetylation; D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage; D002478:Cells, Cultured; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics / Q000378:metabolism*; D019175:DNA Methylation; D000090205:DNA Methyltransferase 3A; D004268:DNA-Binding Proteins / Q000378:metabolism; D004622:Embryo, Mammalian / Q000033:anatomy & histology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D056572:Histone Deacetylase Inhibitors; D006657:Histones / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D053605:Leukemia Inhibitory Factor; D008239:Lysine / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology; D050814:Octamer Transcription Factor-3; D050796:STAT3 Transcription Factor; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D019076:Transgenes
chemical_list: D015415:Biomarkers; D004268:DNA-Binding Proteins; C000715535:Dnmt3a protein, mouse; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; C000619381:Dnmt1 protein, mouse; D008239:Lysine