A novel PPAR alpha/gamma dual agonist inhibits cell growth and induces apoptosis in human glioblastoma T98G cells.
Liu
Da-Chuan
DC
Division of Oncology/Hematology, School of Medicine (Charite, Humboldt University, 10117 Berlin, Germany.
Zang
Chuan-Bing
CB
Liu
Hong-Yu
HY
Possinger
Kurt
K
Fan
Shao-Guang
SG
Elstner
Elena
E
D017209:Apoptosis / Q000187:drug effects*; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D018797:Cell Cycle Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D050760:Cyclin-Dependent Kinase Inhibitor p27; D005260:Female; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism; D010647:Phenyl Ethers / Q000494:pharmacology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D045162:Thiazolidinediones / Q000494:pharmacology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D051028:bcl-2-Associated X Protein
C483680:5-(3-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)-2,4-thiazolidinedione; C494826:BAX protein, human; D018797:Cell Cycle Proteins; D047493:PPAR alpha; D047495:PPAR gamma; D010647:Phenyl Ethers; D019253:Proto-Oncogene Proteins c-bcl-2; D045162:Thiazolidinediones; D025521:Tumor Suppressor Proteins; D051028:bcl-2-Associated X Protein; D050760:Cyclin-Dependent Kinase Inhibitor p27; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases