Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferator-activated receptor (PPAR) alpha in obese mice.
Ide
Tomohiro
T
Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan.
Tsunoda
Masaki
M
Mochizuki
Toshiro
T
Murakami
Koji
K
D000818:Animals; D015415:Biomarkers; D005786:Gene Expression Regulation / Q000187:drug effects; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D055504:Insulin Receptor Substrate Proteins; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D047493:PPAR alpha / Q000819:agonists / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D019000:Phosphotyrosine / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
D015415:Biomarkers; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; C526295:Irs1 protein, mouse; D047493:PPAR alpha; D010750:Phosphoproteins; D011743:Pyrimidines; D019000:Phosphotyrosine; C006253:pirinixic acid; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin