Mutational status of IgVH genes consistent with antigen-driven selection but not percent of mutations has prognostic impact in B-cell chronic lymphocytic leukemia.
Degan
Massimo
M
Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano, Italy.
Rupolo
Maurizio
M
Bo
Michele Dal
MD
Stefanon
Anna
A
Bomben
Riccardo
R
Zucchetto
Antonella
A
Canton
Enrica
E
Berretta
Massimiliano
M
Nanni
Paola
P
Steffan
Agostino
A
Ballerini
Pier Ferruccio
PF
Damiani
Daniela
D
Pucillo
Carlo
C
Attadia
Vincenza
V
Colombatti
Alfonso
A
Gattei
Valter
V
D036541:ADP-ribosyl Cyclase / Q000235:genetics; D051997:ADP-ribosyl Cyclase 1; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000941:Antigens / Q000737:chemistry; D015703:Antigens, CD / Q000235:genetics; D002454:Cell Differentiation; D004252:DNA Mutational Analysis; D005260:Female; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D013997:Time Factors
D000941:Antigens; D015703:Antigens, CD; D007135:Immunoglobulin Variable Region; D008562:Membrane Glycoproteins; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1