Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic beta-cells.
Haase
Claus
C
Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark.
Skak
Kresten
K
Michelsen
Birgitte K
BK
Markholst
Helle
H
D000375:Aging; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001786:Blood Glucose / Q000378:metabolism; D023201:CD40 Ligand / Q000032:analysis / Q000235:genetics*; D003713:Dendritic Cells / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006943:Hyperglycemia / Q000276:immunology; D007328:Insulin / Q000276:immunology*; D007515:Islets of Langerhans / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D013601:T-Lymphocytes / Q000276:immunology
D001786:Blood Glucose; D007328:Insulin; D023201:CD40 Ligand