Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells.
Moodie
Fiona M
FM
ELEGI and Colt Research Laboratories, MRC Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh, UK.
Marwick
John A
JA
Anderson
Charlotte S
CS
Szulakowski
Patryk
P
Biswas
Saibal K
SK
Bauter
Mark R
MR
Kilty
Iain
I
Rahman
Irfan
I
D000111:Acetylcysteine / Q000494:pharmacology; D000123:Acetyltransferases / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D004847:Epithelial Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051548:Histone Acetyltransferases; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D016328:NF-kappa B / Q000378:metabolism*; D018384:Oxidative Stress; D011650:Pulmonary Alveoli / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism; D012907:Smoking
D016207:Cytokines; D016328:NF-kappa B; D012097:Repressor Proteins; D006861:Hydrogen Peroxide; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases; D000111:Acetylcysteine