Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats.
McKenna
Sean D
SD
Serono Reproductive Biology Institute, Rockland, Massachusetts 02370, USA. sean.mckenna@serono.com
Pietropaolo
Michael
M
Tos
Enrico Gillio
EG
Clark
Ann
A
Fischer
David
D
Kagan
David
D
Bao
Bagna
B
Chedrese
P Jorge
PJ
Palmer
Stephen
S
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D005298:Fertility; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D009865:Oocytes / Q000187:drug effects / Q000502:physiology; D010060:Ovulation / Q000187:drug effects*; D010080:Oxazoles / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D011621:Pteridines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011974:Receptors, LH / Q000378:metabolism
D001549:Benzamides; D006063:Chorionic Gonadotropin; D010080:Oxazoles; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011621:Pteridines; D011725:Pyridines; D011974:Receptors, LH; C412083:mesopram; C081896:7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C087566:piclamilast