title: Angiotensin receptor blockade with candesartan attenuates atherosclerosis, plaque disruption, and macrophage accumulation within the plaque in a rabbit model.
authors.affiliation: Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, RW-453, Boston, MA 02115, USA. mjohnst1@bidmc.harvard.edu.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Johnstone
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Perez
authors.forename: Imad
authors.initials: I
authors.lastname: Nasser
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
authors.forename: Anand
authors.initials: A
authors.lastname: Vaidya
authors.forename: Fawaz
authors.initials: F
authors.lastname: Al Ammary
authors.forename: Ben
authors.initials: B
authors.lastname: Schmidt
authors.forename: Gary
authors.initials: G
authors.lastname: Horowitz
authors.forename: Jennifer
authors.initials: J
authors.lastname: Dolgoff
authors.forename: James
authors.initials: J
authors.lastname: Hamilton
authors.forename: William C
authors.initials: WC
authors.lastname: Quist
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001011:Aorta / Q000293:injuries* / Q000473:pathology; D001018:Aortic Diseases / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D002404:Catheterization / Q000009:adverse effects*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004730:Endothelium, Vascular / Q000293:injuries / Q000473:pathology; D008264:Macrophages / Q000187:drug effects*; D011817:Rabbits; D012422:Rupture, Spontaneous; D013777:Tetrazoles / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D002791:Cholesterol, Dietary; D013777:Tetrazoles; D002784:Cholesterol; C077793:candesartan cilexetil