An in vitro screening assay based on synthetic prion protein peptides for identification of fibril-interfering compounds.
Boshuizen
Ronald S
RS
Pepscan Systems B.V., Edelhertweg 15, 8219 PH Lelystad, The Netherlands. r.s.boshuizen@pepscan.nl
Langeveld
Jan P M
JP
Salmona
Mario
M
Williams
Alun
A
Meloen
Rob H
RH
Langedijk
Johannes P M
JP
D000595:Amino Acid Sequence; D052160:Benzothiazoles; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005456:Fluorescent Dyes; D005780:Gelatin; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D009454:Neurofibrils / Q000187:drug effects* / Q000378:metabolism*; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011328:Prions / Q000037:antagonists & inhibitors* / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013194:Staining and Labeling; D013752:Tetracycline; D013844:Thiazoles; D013997:Time Factors
D052160:Benzothiazoles; D005456:Fluorescent Dyes; D010446:Peptide Fragments; D011328:Prions; D013844:Thiazoles; C009462:thioflavin T; D005780:Gelatin; D013752:Tetracycline