title: In vitro and in vivo antithrombotic activity of PD-198961, a novel synthetic factor Xa inhibitor.
authors.affiliation: Cardiovascular Pharmacology, Pfizer Global R&D, Ann Arbor Laboratories, Ann Arbor, Michigan 48105, USA. Liguo.Chi@pfizer.com
authors.forename: Liguo
authors.initials: L
authors.lastname: Chi
authors.forename: Yun-Wen
authors.initials: YW
authors.lastname: Peng
authors.forename: Glenn
authors.initials: G
authors.lastname: Gibson
authors.forename: Gary
authors.initials: G
authors.lastname: Hicks
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Mertz
authors.forename: Stephen
authors.initials: S
authors.lastname: Rapundalo
authors.forename: Nancy
authors.initials: N
authors.lastname: Janiczek
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Edmunds
authors.forename: Robert
authors.initials: R
authors.lastname: Leadley
mesh_terms: D000818:Animals; D001760:Bleeding Time; D002712:Chlorides; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D065427:Factor Xa Inhibitors; D005290:Ferric Compounds; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D011810:Quinoxalines / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013045:Species Specificity; D013927:Thrombosis / Q000139:chemically induced / Q000188:drug therapy; D013997:Time Factors
chemical_list: D002712:Chlorides; D065427:Factor Xa Inhibitors; D005290:Ferric Compounds; D005343:Fibrinolytic Agents; C501117:PD-198961; D011810:Quinoxalines; C024555:ferric chloride