Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.
Frelin
Catherine
C
Institut National de la Santé et de la Recherche Médicale U526, Physiopathologie de la Survie et de Mort Cellulaires et Infetions Virales, Nice, France.
Imbert
Véronique
V
Griessinger
Emmanuel
E
Peyron
Annie-Claude
AC
Rochet
Nathalie
N
Philip
Patrick
P
Dageville
Christian
C
Sirvent
Anne
A
Hummelsberger
Michaël
M
Bérard
Etienne
E
Dreano
Michel
M
Sirvent
Nicolas
N
Peyron
Jean-François
JF
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D002648:Child; D019008:Drug Resistance, Neoplasm; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005047:Etoposide / Q000494:pharmacology; D005260:Female; D006801:Humans; D051550:I-kappa B Kinase; D007951:Leukemia, Myeloid; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism
D018952:Antigens, CD34; D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D016328:NF-kappa B; D005047:Etoposide; D017346:Protein Serine-Threonine Kinases; C496559:CHUK protein, human; D051550:I-kappa B Kinase; C496560:IKBKB protein, human; C496565:IKBKE protein, human; D020169:Caspases