Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses.
Evans
Mark L
ML
Diabetes Endocrine Research Center, Fitkin 1, Yale School of Medicine, 333 Cedar St., New Haven, CT 06520, USA.
McCrimmon
Rory J
RJ
Flanagan
Daniel E
DE
Keshavarz
Tara
T
Fan
Xiaoning
X
McNay
Ewan C
EC
Jacob
Ralph J
RJ
Sherwin
Robert S
RS
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002096:C-Peptide / Q000097:blood; D002552:Cerebral Ventricles / Q000502:physiology; D005905:Glyburide / Q000008:administration & dosage / Q000494:pharmacology*; D007263:Infusions, Parenteral; D007328:Insulin / Q000097:blood; D008297:Male; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D015221:Potassium Channels; D005905:Glyburide