PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.
Chen
Jing
J
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Deangelo
Daniel J
DJ
Kutok
Jeffery L
JL
Williams
Ifor R
IR
Lee
Benjamin H
BH
Wadleigh
Martha
M
Duclos
Nicole
N
Cohen
Sarah
S
Adelsperger
Jennifer
J
Okabe
Rachel
R
Coburn
Allison
A
Galinsky
Ilene
I
Huntly
Brian
B
Cohen
Pamela S
PS
Meyer
Thomas
T
Fabbro
Doriano
D
Roesel
Johannes
J
Banerji
Lolita
L
Griffin
James D
JD
Xiao
Sheng
S
Fletcher
Jonathan A
JA
Stone
Richard M
RM
Gilliland
D Gary
DG
D000818:Animals; D002460:Cell Line; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D004195:Disease Models, Animal; D005260:Female; D014644:Genetic Variation; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D051496:Receptor, Fibroblast Growth Factor, Type 1; D017468:Receptors, Fibroblast Growth Factor / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014170:Transformation, Genetic; D014178:Translocation, Genetic; D016335:Zinc Fingers
D017468:Receptors, Fibroblast Growth Factor; C496348:FGFR1 protein, human; C496349:Fgfr1 protein, mouse; D020794:Receptor Protein-Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1; D019311:Staurosporine; C059539:midostaurin