SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa.
Smallheer
Joanne M
JM
Bristol-Myers Squibb Company, PO Box 5400, Princeton, NJ 08543-5400, USA. joanne.smallheer@bms.com
Alexander
Richard S
RS
Wang
Jianmin
J
Wang
Shuaige
S
Nakajima
Suanne
S
Rossi
Karen A
KA
Smallwood
Angela
A
Barbera
Frank
F
Burdick
Debra
D
Luettgen
Joseph M
JM
Knabb
Robert M
RM
Wexler
Ruth R
RR
Jadhav
Prabhakar K
PK
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001665:Binding Sites; D018360:Crystallography, X-Ray; D015949:Factor IXa / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D015951:Factor Xa / Q000737:chemistry*; D065427:Factor Xa Inhibitors; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; D065427:Factor Xa Inhibitors; D011720:Pyrazoles; D015949:Factor IXa; D015951:Factor Xa