HSV vector-delivery of GDNF in a rat model of PD: partial efficacy obscured by vector toxicity.
Monville
Christelle
C
School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK. monville@cf.ac.uk
Torres
Eduardo
E
Thomas
Eleri
E
Scarpini
Cinzia G
CG
Muhith
Justna
J
Lewis
Jeff
J
Finn
Jaquie
J
Smith
Chris
C
Cai
Shijie
S
Efstathiou
Stacey
S
Howard
Keith
K
Dunnett
Stephen B
SB
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D005822:Genetic Vectors / Q000008:administration & dosage / Q000235:genetics / Q000633:toxicity*; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000235:genetics / Q000633:toxicity*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018139:Simplexvirus / Q000235:genetics
C495041:Gdnf protein, rat; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors