Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role.
Small
George W
GW
The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.
Shi
Yue Y
YY
Edmund
Natalie A
NA
Somasundaram
Sivagurunathan
S
Moore
Dominic T
DT
Orlowski
Robert Z
RZ
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001897:Boronic Acids / Q000494:pharmacology*; D000069286:Bortezomib; D001940:Breast / Q000166:cytology; D001943:Breast Neoplasms / Q000473:pathology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D002461:Cell Line, Transformed; D045744:Cell Line, Tumor; D054638:Dual Specificity Phosphatase 1; D005347:Fibroblasts / Q000502:physiology; D016259:Genes, myc; D006801:Humans; D017874:Immediate-Early Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008819:Mice, Nude; D010749:Phosphoprotein Phosphatases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D011480:Protease Inhibitors / Q000494:pharmacology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D054645:Protein Phosphatase 1; D017027:Protein Tyrosine Phosphatases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D011719:Pyrazines / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000378:metabolism; D014183:Transplantation, Heterologous
D001897:Boronic Acids; D018797:Cell Cycle Proteins; D017874:Immediate-Early Proteins; D011480:Protease Inhibitors; D011719:Pyrazines; D011994:Recombinant Proteins; D000069286:Bortezomib; D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1; C517019:DUSP1 protein, human; D054638:Dual Specificity Phosphatase 1; C517020:Dusp1 protein, mouse; D017027:Protein Tyrosine Phosphatases; D046988:Proteasome Endopeptidase Complex