Pharmacokinetics of rofecoxib in children with sickle cell hemoglobinopathy.
Prescilla
Randy P
RP
Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, School of Medicine, Wayne State University, Children's Hospital of Michigan, Detroit, Michigan, USA. rprescil@med.wayne.edu
Frattarelli
Daniel A C
DA
Haritos
Demitris
D
Aranda
Jacob V
JV
Edwards
David J
DJ
D000284:Administration, Oral; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D007783:Lactones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D008657:Metabolic Clearance Rate; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D013450:Sulfones; D013535:Suspensions
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D013450:Sulfones; D013535:Suspensions; C116926:rofecoxib