Ketoamide-based inhibitors of cysteine protease, cathepsin K: P3 modifications.
Tavares
Francis X
FX
Department of Medicinal Chemistry, Discovery Research Biology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. francis.x.tavares@gsk.com
Deaton
David N
DN
Miller
Larry R
LR
Wright
Lois L
LL
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D056657:Cathepsin K; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
D000577:Amides; D003503:Cyclobutanes; D007659:Ketones; D002403:Cathepsins; D056657:Cathepsin K