Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors.
Alagille
David
D
EA 3247 Laboratoire de Chimie Organique, UFR des Sciences Pharmaceutiques, Université de Tours, 31 Avenue Monge, 37200 Tours, France.
Pfeiffer
Bruno
B
Scalbert
Elizabeth
E
Ferry
Gilles
G
Boutin
Jean A
JA
Renard
Pierre
P
Viaud-Massuard
Marie-Claude
MC
D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D053818:Chymases; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014162:Transfection
D004791:Enzyme Inhibitors; D006827:Hydantoins; D007211:Indoles; D011994:Recombinant Proteins; D015842:Serine Proteinase Inhibitors; D044005:Tetrahydroisoquinolines; D012697:Serine Endopeptidases; D053818:Chymases