Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore.
Grundt
Peter
P
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U.K.
Williams
Ian A
IA
Lewis
John W
JW
Husbands
Stephen M
SM
D001665:Binding Sites; D008958:Models, Molecular; D009292:Narcotic Antagonists / Q000138:chemical synthesis / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
D009292:Narcotic Antagonists; D010880:Piperidines; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D013764:Tetrahydronaphthalenes