title: Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.
authors.affiliation: Departments of Microbiology and Immunology, Neurology, and Pathology, Georgetown University Medical Center, Washington, D.C. 20007, USA.
authors.forename: Niklas K U
authors.initials: NK
authors.lastname: Koehler
authors.forename: Chao-Yie
authors.initials: CY
authors.lastname: Yang
authors.forename: Judith
authors.initials: J
authors.lastname: Varady
authors.forename: Yipin
authors.initials: Y
authors.lastname: Lu
authors.forename: Xiong-Wu
authors.initials: XW
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Daxu
authors.initials: D
authors.lastname: Yin
authors.forename: Margreet
authors.initials: M
authors.lastname: Bartels
authors.forename: Bi-ying
authors.initials: BY
authors.lastname: Xu
authors.forename: Peter P
authors.initials: PP
authors.lastname: Roller
authors.forename: Ya-qiu
authors.initials: YQ
authors.lastname: Long
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Michael
authors.initials: M
authors.lastname: Kattah
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: Cohn
authors.forename: Kelly
authors.initials: K
authors.lastname: Moran
authors.forename: Eurona
authors.initials: E
authors.lastname: Tilley
authors.forename: John R
authors.initials: JR
authors.lastname: Richert
authors.forename: Shaomeng
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001667:Binding, Competitive; D002460:Cell Line; D016208:Databases, Factual; D006684:HLA-DR Antigens / Q000737:chemistry / Q000276:immunology*; D059811:HLA-DRB1 Chains; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D051379:Mice; D008958:Models, Molecular; D004676:Myelin Basic Protein / Q000737:chemistry / Q000276:immunology*; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*; D011810:Quinoxalines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D001391:Azo Compounds; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C492962:HLA-DRB1*13:01 antigen; C489631:HLA-DRB1*15:01 antigen; D007376:Interleukin-2; D004676:Myelin Basic Protein; D009281:Naphthalenes; D010446:Peptide Fragments; D011810:Quinoxalines; C492963:myelin basic protein 152-165