title: Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.
authors.affiliation: Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK. M.D.Lloyd@bath.ac.uk
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Lloyd
authors.forename: Richard L
authors.initials: RL
authors.lastname: Pederick
authors.forename: Ramanathan
authors.initials: R
authors.lastname: Natesh
authors.forename: L W Lawrence
authors.initials: LW
authors.lastname: Woo
authors.forename: Atul
authors.initials: A
authors.lastname: Purohit
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Reed
authors.forename: K Ravi
authors.initials: KR
authors.lastname: Acharya
authors.forename: Barry V L
authors.initials: BV
authors.lastname: Potter
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism*; D001665:Binding Sites; D024402:Carbonic Anhydrase II / Q000737:chemistry* / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006207:Half-Life; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D009584:Nitrogen / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry* / Q000378:metabolism*; D013451:Sulfonic Acids; D015032:Zinc / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D013449:Sulfonamides; D013451:Sulfonic Acids; C520511:irosustat; D024402:Carbonic Anhydrase II; D015032:Zinc; D009584:Nitrogen