title: Effects and mechanisms of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats.
authors.affiliation: Zhejiang Respiratory Drugs Research Laboratory of State Food and Drugs Administration of China, School of Medicine, Zhejiang University, Hangzhou 310031, China. yhgwei@hotmail.com
authors.forename: Yao Hong
authors.initials: YH
authors.lastname: Wei
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.forename: Chen Ji
authors.initials: CJ
authors.lastname: Qiang
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001835:Body Weight / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002681:China; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D005620:Freund's Adjuvant / Q000008:administration & dosage / Q000009:adverse effects; D007279:Injections, Subcutaneous; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000494:pharmacology* / Q000627:therapeutic use; D016753:Interleukin-10 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007555:Isoxazoles / Q000494:pharmacology / Q000627:therapeutic use; D007719:Knee Joint / Q000187:drug effects / Q000503:physiopathology / Q000648:ultrastructure; D000077339:Leflunomide; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011720:Pyrazoles / Q000008:administration & dosage / Q000493:pharmacokinetics; D011725:Pyridines / Q000008:administration & dosage / Q000493:pharmacokinetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects / Q000502:physiology; D013582:Synovial Fluid / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: C104334:FR 167653; D007375:Interleukin-1; D007555:Isoxazoles; D011720:Pyrazoles; D011725:Pyridines; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D005620:Freund's Adjuvant; D000077339:Leflunomide