title: Cell cycle arrest at the initiation step of human chromosomal DNA replication causes DNA damage.
authors.affiliation: Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, UK.
authors.forename: Dávid
authors.initials: D
authors.lastname: Szüts
authors.forename: Torsten
authors.initials: T
authors.lastname: Krude
mesh_terms: D015082:2,2'-Dipyridyl / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D064007:Ataxia Telangiectasia Mutated Proteins; D015153:Blotting, Western; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D002460:Cell Line; D049109:Cell Proliferation; D000071877:Checkpoint Kinase 1; D002614:Chelating Agents / Q000494:pharmacology; D002875:Chromosomes / Q000648:ultrastructure*; D000077768:Ciclopirox; D004247:DNA / Q000737:chemistry; D004249:DNA Damage; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism; D006367:HeLa Cells; D006657:Histones / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007501:Iron / Q000378:metabolism; D008898:Mimosine / Q000494:pharmacology*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011728:Pyridones / Q000494:pharmacology*; D051716:Replication Protein A; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D018797:Cell Cycle Proteins; D002614:Chelating Agents; D004268:DNA-Binding Proteins; C468783:H2AX protein, human; D006657:Histones; D011728:Pyridones; C497167:RPA1 protein, human; D051716:Replication Protein A; D000077768:Ciclopirox; D008898:Mimosine; D015082:2,2'-Dipyridyl; D004247:DNA; D007501:Iron; D011494:Protein Kinases; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; C000605867:CHEK1 protein, human; D000071877:Checkpoint Kinase 1; D017346:Protein Serine-Threonine Kinases