title: Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.
authors.affiliation: Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Villani
authors.forename: Valentina
authors.initials: V
authors.lastname: Appierto
authors.forename: Elena
authors.initials: E
authors.lastname: Cavadini
authors.forename: Manuela
authors.initials: M
authors.lastname: Valsecchi
authors.forename: Sandro
authors.initials: S
authors.lastname: Sonnino
authors.forename: Robert W
authors.initials: RW
authors.lastname: Curley
authors.forename: Franca
authors.initials: F
authors.lastname: Formelli
mesh_terms: D016588:Anticarcinogenic Agents / Q000097:blood*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003577:Cytochrome P-450 Enzyme System / Q000097:blood* / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D017313:Fenretinide / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics*; D005822:Genetic Vectors; D006801:Humans; D015151:Immunoblotting; D013058:Mass Spectrometry; D010051:Ovarian Neoplasms / Q000097:blood* / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism; D000072516:Retinoic Acid 4-Hydroxylase; D012177:Retinol-Binding Proteins / Q000096:biosynthesis*; D054840:Retinol-Binding Proteins, Cellular; D054839:Retinol-Binding Proteins, Plasma; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D013997:Time Factors; D014162:Transfection; D014212:Tretinoin / Q000494:pharmacology; D015854:Up-Regulation
chemical_list: C494898:4-oxofenretinide; D016588:Anticarcinogenic Agents; D018076:DNA, Complementary; C518456:RBP1 protein, human; D012333:RNA, Messenger; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular; D054839:Retinol-Binding Proteins, Plasma; D017313:Fenretinide; D014212:Tretinoin; D003577:Cytochrome P-450 Enzyme System; D000072516:Retinoic Acid 4-Hydroxylase; D010100:Oxygen