In vivo elimination of CD25+ regulatory T cells leads to tumor rejection of B16F10 melanoma, when combined with interleukin-12 gene transfer.
Nagai
Hiroshi
H
Division of Dermatology, Department of Clinical Molecular Medicine Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. hnagai@med.kobe-u.ac.jp
Horikawa
Tatsuya
T
Hara
Isao
I
Fukunaga
Atsushi
A
Oniki
Shuntaro
S
Oka
Masahiro
M
Nishigori
Chikako
C
Ichihashi
Masamitsu
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D045744:Cell Line, Tumor; D018014:Gene Transfer Techniques; D018664:Interleukin-12 / Q000235:genetics; D007694:Killer Cells, Natural / Q000166:cytology; D008212:Lymphocyte Depletion; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D051379:Mice; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015375:Receptors, Interleukin-2; D018664:Interleukin-12