Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.
Komander
David
D
Division of Biological Chemistry & Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, Scotland, UK.
Fairservice
Alison
A
Deak
Maria
M
Kular
Gursant S
GS
Prescott
Alan R
AR
Peter Downes
C
C
Safrany
Stephen T
ST
Alessi
Dario R
DR
van Aalten
Daan M F
DM
D064413:3-Phosphoinositide-Dependent Protein Kinases; D000595:Amino Acid Sequence; D001665:Binding Sites; D001667:Binding, Competitive; D002460:Cell Line; D018360:Crystallography, X-Ray; D003600:Cytosol / Q000737:chemistry / Q000378:metabolism; D031541:Fluorescence Resonance Energy Transfer; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007295:Inositol Phosphates / Q000378:metabolism*; D008024:Ligands; D050356:Lipid Metabolism; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D009154:Mutation; D010716:Phosphatidylinositols / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry
D007295:Inositol Phosphates; D008024:Ligands; D010716:Phosphatidylinositols; D011993:Recombinant Fusion Proteins; D014867:Water; D005982:Glutathione Transferase; D064413:3-Phosphoinositide-Dependent Protein Kinases; C578562:PDPK1 protein, human; D017346:Protein Serine-Threonine Kinases