Effect of itraconazole on the pharmacokinetics of inhaled lidocaine.
Isohanni
Mika H
MH
Department of Anaesthesia, Diacor Hospital, Helsinki, Finland. mika.isohanni@diacor.fi
Neuvonen
Pertti J
PJ
Olkkola
Klaus T
KT
D000280:Administration, Inhalation; D000328:Adult; D000779:Anesthetics, Local / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004311:Double-Blind Method; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000097:blood / Q000494:pharmacology*; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male
D000779:Anesthetics, Local; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D017964:Itraconazole; D008012:Lidocaine; C001173:monoethylglycinexylidide; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human