title: Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.
authors.affiliation: Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, NC 27599-7295, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Hu
authors.forename: Chad M
authors.initials: CM
authors.lastname: McCall
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ohta
authors.forename: Yue
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D000595:Amino Acid Sequence; D018797:Cell Cycle Proteins / Q000378:metabolism* / Q000528:radiation effects; D002460:Cell Line; D044842:Cullin Proteins / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage / Q000528:radiation effects*; D004268:DNA-Binding Proteins / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006367:HeLa Cells; D006801:Humans; D016297:Mutagenesis, Site-Directed; D034622:RNA Interference; D011994:Recombinant Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: C486317:CAND1 protein, human; C467199:CDT1 protein, human; C114234:CUL4A protein, human; D018797:Cell Cycle Proteins; D044842:Cullin Proteins; C091435:DDB1 protein, human; D004268:DNA-Binding Proteins; C490414:Ddb1 protein, rat; D011994:Recombinant Proteins; D014157:Transcription Factors; D014452:Ubiquitins; D043743:Ubiquitin-Protein Ligase Complexes