Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.
Minutoli
Letteria
L
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina AOU G. Martino Torre Biologica 5th floor, Via Consolare Valeria, Gazzi 98100, Messina, Italy.
Altavilla
Domenica
D
Marini
Herbert
H
Passaniti
Maria
M
Bitto
Alessandra
A
Seminara
Paolo
P
Venuti
Francesco S
FS
Famulari
Ciro
C
Macrì
Antonio
A
Versaci
Antonino
A
Squadrito
Francesco
F
D000681:Amylases / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D015153:Blotting, Western; D002108:Ceruletide / Q000633:toxicity; D004195:Disease Models, Animal; D004487:Edema / Q000473:pathology*; D004789:Enzyme Activation / Q000187:drug effects; D006652:Histological Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008049:Lipase / Q000097:blood; D048670:MAP Kinase Kinase 4; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D048052:Mitogen-Activated Protein Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009841:Oligonucleotides; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced* / Q000517:prevention & control*; D009195:Peroxidase / Q000378:metabolism; D012313:RNA / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000873:Anthracenes; D009841:Oligonucleotides; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; C432165:pyrazolanthrone; D012313:RNA; D002108:Ceruletide; D009195:Peroxidase; D048031:JNK Mitogen-Activated Protein Kinases; D048052:Mitogen-Activated Protein Kinase 3; D048670:MAP Kinase Kinase 4; D020929:Mitogen-Activated Protein Kinase Kinases; D008049:Lipase; D000681:Amylases