title: Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation.
authors.affiliation: Department of Gene Function & Target Validation, Celltech R & D, Inc, Bothell, WA 98021, USA.
authors.forename: May Kung
authors.initials: MK
authors.lastname: Sutherland
authors.forename: James C
authors.initials: JC
authors.lastname: Geoghegan
authors.forename: Changpu
authors.initials: C
authors.lastname: Yu
authors.forename: Eileen
authors.initials: E
authors.lastname: Turcott
authors.forename: John E
authors.initials: JE
authors.lastname: Skonier
authors.forename: David G
authors.initials: DG
authors.lastname: Winkler
authors.forename: John A
authors.initials: JA
authors.lastname: Latham
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000469:Alkaline Phosphatase / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D010012:Osteogenesis / Q000187:drug effects / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D061945:Caspase Inhibitors; D004791:Enzyme Inhibitors; D005819:Genetic Markers; C422903:SOST protein, human; D000469:Alkaline Phosphatase; D020169:Caspases