A cyclic peptide mimicking the third intracellular loop of the V2 vasopressin receptor inhibits signaling through its interaction with receptor dimer and G protein.
Granier
Sébastien
S
Unité INSERM U469, CCIPE, 141 rue de la Cardonille, 34094 Montpellier, France.
Terrillon
Sonia
S
Pascal
Robert
R
Déméné
Hélène
H
Bouvier
Michel
M
Guillon
Gilles
G
Mendre
Christiane
C
D000262:Adenylyl Cyclases / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry; D001669:Biochemical Phenomena; D001671:Biochemistry; D001921:Brain / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002942:Circular Dichroism; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D004735:Energy Transfer; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000737:chemistry; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008156:Luciferases / Q000378:metabolism; D008164:Luminescent Proteins / Q000737:chemistry; D008954:Models, Biological; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D010957:Plasmids / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D051381:Rats; D017483:Receptors, Vasopressin / Q000737:chemistry*; D048790:Renilla; D015398:Signal Transduction; D013050:Spectrometry, Fluorescence
D001426:Bacterial Proteins; D008164:Luminescent Proteins; D010455:Peptides; D017483:Receptors, Vasopressin; C054562:yellow fluorescent protein, Bacteria; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D006160:Guanosine Triphosphate; D008156:Luciferases; D000262:Adenylyl Cyclases