Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression.
Wu
Feng
F
Lawson Health Research Institute, University of Western Ontario, London, Ontario, N6A 5C1, Canada.
Wilson
John X
JX
Tyml
Karel
K
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000201:enzymology / Q000503:physiopathology; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002432:Cecum / Q000293:injuries; D004334:Drug Administration Schedule; D004790:Enzyme Induction; D007416:Intestinal Perforation / Q000150:complications; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000098:blood supply; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D052247:Nitric Oxide Synthase Type II; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D012333:RNA, Messenger / Q000096:biosynthesis; D018805:Sepsis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D014661:Vasoconstriction / Q000187:drug effects*
D009566:Nitrates; D009573:Nitrites; D012333:RNA, Messenger; D000804:Angiotensin II; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D001205:Ascorbic Acid