title: Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Xiao
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: John R
authors.initials: JR
authors.lastname: Vance
authors.forename: Robert S
authors.initials: RS
authors.lastname: Sidwell
authors.forename: Hui-Kang
authors.initials: HK
authors.lastname: Wang
authors.forename: Ming S
authors.initials: MS
authors.lastname: Chen
authors.forename: Qian
authors.initials: Q
authors.lastname: Shi
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D004355:Drug Stability; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D044967:Serum; D012995:Solubility; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D059005:Topoisomerase II Inhibitors; D011034:Podophyllotoxin