Germinal center kinase is required for optimal Jun N-terminal kinase activation by Toll-like receptor agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization.
Zhong
Jian
J
Molecular Cardiology Research Institute Tufts-New England Medical Center, 750 Washington St., Box 8486, Boston, MA 02111, USA.
Kyriakis
John M
JM
D000818:Animals; D019013:CD40 Antigens / Q000378:metabolism; D002460:Cell Line; D004789:Enzyme Activation; D000081410:Germinal Center Kinases; D006801:Humans; D007369:Interferon Inducers / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008050:Lipid A / Q000378:metabolism; D008070:Lipopolysaccharides / Q000378:metabolism; D048728:MAP Kinase Kinase Kinase 1 / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000819:agonists* / Q000378:metabolism; D011070:Poly I-C / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D061988:Proteasome Inhibitors; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D011956:Receptors, Cell Surface / Q000819:agonists* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D048029:TNF Receptor-Associated Factor 6 / Q000378:metabolism*; D051193:Toll-Like Receptors; D025801:Ubiquitin / Q000378:metabolism*
D019013:CD40 Antigens; D000081410:Germinal Center Kinases; D007369:Interferon Inducers; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D061988:Proteasome Inhibitors; D011956:Receptors, Cell Surface; D048029:TNF Receptor-Associated Factor 6; D051193:Toll-Like Receptors; D025801:Ubiquitin; D017346:Protein Serine-Threonine Kinases; D048031:JNK Mitogen-Activated Protein Kinases; D048728:MAP Kinase Kinase Kinase 1; D046988:Proteasome Endopeptidase Complex; D011070:Poly I-C