title: Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a double-blind, placebo-controlled randomised multicenter trial [ISRCTN38327949].
authors.affiliation: Department of Surgery, University Medical Center Utrecht PO Box 85500, HP G04,228, 3508 GA Utrecht, The Netherlands. m.besselink@chir.azu.nl
authors.forename: Marc G H
authors.initials: MG
authors.lastname: Besselink
authors.forename: Harro M
authors.initials: HM
authors.lastname: Timmerman
authors.forename: Erik
authors.initials: E
authors.lastname: Buskens
authors.forename: Vincent B
authors.initials: VB
authors.lastname: Nieuwenhuijs
authors.forename: Louis M A
authors.initials: LM
authors.lastname: Akkermans
authors.forename: Hein G
authors.initials: HG
authors.lastname: Gooszen
mesh_terms: D000208:Acute Disease; D000328:Adult; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D048191:Lactiplantibacillus plantarum; D015337:Multicenter Studies as Topic; D009336:Necrosis / Q000517:prevention & control; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000517:prevention & control*; D019936:Probiotics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D018401:Sample Size