The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.
Hagenbeek
Thijs J
TJ
Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Naspetti
Marianne
M
Malergue
Fabrice
F
Garçon
Fabien
F
Nunès
Jacques A
JA
Cleutjens
Kitty B J M
KB
Trapman
Jan
J
Krimpenfort
Paul
P
Spits
Hergen
H
D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D017931:DNA Primers; D005434:Flow Cytometry; D005838:Genotype; D015151:Immunoblotting; D047468:Immunoprecipitation; D015851:Interleukin-7 / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D051059:PTEN Phosphohydrolase; D016133:Polymerase Chain Reaction; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism* / Q000502:physiology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D013950:Thymus Gland / Q000378:metabolism* / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism* / Q000502:physiology
D017931:DNA Primers; D015851:Interleukin-7; D016693:Receptors, Antigen, T-Cell, alpha-beta; D025521:Tumor Suppressor Proteins; D017027:Protein Tyrosine Phosphatases; D051059:PTEN Phosphohydrolase; C487757:Pten protein, mouse