[Cerebral aneurysms in identical twins].
The hypothesis that genetic factors play a role in the genesis of cerebral aneurysms may be supported by clinical analysis of cerebral aneurysms in identical twins. In addition to reporting the present case, we review the literature on clinical features and genetical considerations in this matter. A forty-two-year-old male presented with subarachnoid hemorrhage (SAH) due to a left MCA aneurysm. At the age of 39, his identical twin brother also had SAH due to a ruptured left MCA aneurysm. This identical twin brother and his father's sisters died of SAH. Venous blood of the patient and his parents was collected to determine apolipoprotein E, angiotensinogen, angiotensin-converting enzyme, and very low density lipoprotein receptor genes. This analysis suggested a strong genetic association of apolipoprotein E epsilon4 with the pathogenesis. Including our cases, 13 cases of cerebral aneurysms in identical twins have been reported. There was a total of 37 aneurysms. Six twins had the same sites of aneurysm. These aneurysms show a tendency to be small in size, and to cause a high frequency of SAH occurring at a similar age. In young adults, cerebral aneurysms in identical twins tend to rupture. A screening diagnosis should be carried out as early as possible on an asymptomatic twin when the other has been discovered to have a ruptured cerebral aneurysm. Preventive treatment and systemic genome-wide linkage study should be conducted.
Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center, 1163 Tate-machi, Hachioji, Tokyo 193-0998, Japan. shin5-oh@tokyo-med.ac.jp
Shingo
S
Ohno
Yukio
Y
Ikeda
Toshiaki
T
Onitsuka
Satoshi
S
Nakajima
Hiroyuki
H
Uchino
Jo
J
Haraoka
Zentaro
Z
Yamagata
D000328:Adult; D017542:Aneurysm, Ruptured / Q000150:complications / Q000235:genetics* / Q000601:surgery; D001057:Apolipoproteins E / Q000235:genetics; D004200:Diseases in Twins; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000235:genetics* / Q000601:surgery; D008297:Male; D011110:Polymorphism, Genetic; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000209:etiology; D016896:Treatment Outcome; D014430:Twins, Monozygotic
D001057:Apolipoproteins E