[Changes in extracellular K+ concentration modulate properties of voltage dependent K+ channel conductance in PC-12 cells].
The complex processing and integration of signals observed in neurons are facilitated by the diverse range of gating properties of the ion channels in this cell type, particularly the voltage-gated K+ channels (Kv). A distinctive combination of K+ channels endows neurons with a broad repertoire of excitable properties and allows each neuron to respond in a specific manner to a given input at a given time. The properties of many K+ channels can be modulated by second messenger pathways activated by neurotransmitters and other stimuli. K+ channels are among the most frequent targets of the actions of several signalling systems.
N Ia
NIa
Boĭko
V V
VV
Kucher
N Kh
NKh
Pohoriela
I S
IS
Mahura
D000818:Animals; D003470:Culture Media; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D016716:PC12 Cells; D011188:Potassium / Q000378:metabolism*; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D019789:Tetraethylammonium / Q000494:pharmacology
D003470:Culture Media; D024642:Potassium Channels, Voltage-Gated; D019789:Tetraethylammonium; D011188:Potassium