Electrochemical generation of active oxygen into aqueous solutions for organism detoxification.
A method has been developed to synthesize long-living active oxygen in Na(2)SO(4) solution. The inactivity of oxygen containing synthesized solutions toward formed elements of blood has been observed. The interactions of some metabolites and xenobiotics in blood and plasma with the active oxygen solution were investigated. The kinetic parameters of the oxidizing detoxification of blood containing endotoxins and xenobiotics were obtained. Solutions containing sodium sulfate and active oxygen accelerate metabolic processes. The synthesized solution continued to detoxify through oxidizing reactions during a 72 h period.
N.V. Sklifosovsky Research Institute for Emergency Medicine, 3, Sukharevskaya Ploshchad, Moscow, 129010, Russia.
Mark M
MM
Goldin
Alexander G
AG
Volkov
Yuri S
YS
Goldfarb
Evgeny A
EA
Luzhnikov
D004563:Electrochemistry; D004731:Endotoxins / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D007700:Kinetics; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D011041:Poisoning / Q000628:therapy; D013431:Sulfates / Q000737:chemistry; D015262:Xenobiotics / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*
D004731:Endotoxins; D013431:Sulfates; D015262:Xenobiotics; C012036:sodium sulfate; D010100:Oxygen