[Experimental study on the effect of low molecular DNA from salmon milt on hemopoiesis].
Biological activity of low molecular DNA isolated from salmon milt was studied. When administered subcutaneously to mice with with acute experimental radiation disease in a course dose of 10 mg/kg, it showed a therapeutic effect, stimulated hemopoiesis, increased the survival rate and the average life span of the animals. Moreover, its marked effect on the humoral immunity was observed.
Fedianina
L N
LN
Potapova
V V
VV
Ivanushko
L A
LA
Besednova
N N
NN
Epshteĭn
L N
LN
Orlovskaia
I A
IA
Blinov
B G
BG
D000208:Acute Disease; D000818:Animals; D021461:Animals, Outbred Strains; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006388:Hemagglutinins / Q000096:biosynthesis; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D007279:Injections, Subcutaneous; D008136:Longevity / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects
D006388:Hemagglutinins; D004247:DNA