Screening of wood damaging fungi and macrofungi for inhibitors of pancreatic lipase.
A total of 120 methanol and dichloromethane extracts, from 60 species of wood-damaging fungi and 50 methanol/water extracts from macrofungi were screened for inhibition of pancreatic lipase using the chromogenic substrate p-nitrophenylpalmitate. Of the extracts screened, those from Laetiporus sulphureus, Tylopilus felleus and Hygrocybe conica exhibited the highest lipase inhibitory activities of 83% +/- 5%, 96% +/- 3% and 97% +/- 5%, respectively.
Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI-1000, Slovenia. petra.slanc@ffa.uni-lj.si
Petra
P
Slanc
Bojan
B
Doljak
Ales
A
Mlinaric
Borut
B
Strukelj
D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005658:Fungi; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors*; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014934:Wood
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D008049:Lipase