The tau H2 haplotype is almost exclusively Caucasian in origin.
We have assessed the distribution of the tau H1/H2 haplotype in the publicly available reference series of samples with representatives of most racial groups. This analysis shows that the H2 haplotype is probably exclusively Caucasian in origin and its marginal occurrence in other racial groups is likely to reflect admixture. We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies.
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Whitney
W
Evans
Hon Chung
HC
Fung
John
J
Steele
Johanna
J
Eerola
Pentti
P
Tienari
Alan
A
Pittman
Rohan de
Rd
Silva
Amanda
A
Myers
Fabienne Wavrant-De
FW
Vrieze
Andrew
A
Singleton
John
J
Hardy
D005787:Gene Frequency; D005820:Genetic Testing / Q000379:methods; D006239:Haplotypes; D006801:Humans; D024801:Tauopathies / Q000453:epidemiology / Q000235:genetics*; D044465:White People / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins