A new lignan glycoside and phenylethanoid glycosides from Strobilanthes cusia BREMEK.
The root of Strobilanthes cusia BREMEK. (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used to treat influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia, mumps, and severe acute respiratory syndrome (SARS). In this study, we found a new lignan glycoside (6) and two new phenylethanoid glycosides (7, 8) together with five known compounds as chemical constituents of Strobilanthes cusia root. Some samples were examined for anti-herpes simplex virus type-1 (HSV-1) activity. Among the tested samples, lupeol showed anti-HSV-1 activity (EC(50): 11.7 microM) and showed 100% inhibition of virus plaque formation at 58.7 microM.
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Tomonori
T
Tanaka
Tsuyoshi
T
Ikeda
Miho
M
Kaku
Xing-Hua
XH
Zhu
Masafumi
M
Okawa
Kazumi
K
Yokomizo
Masaru
M
Uyeda
Toshihiro
T
Nohara
D027901:Acanthaceae; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010666:Phenylpropionates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots; D013237:Stereoisomerism; D014709:Vero Cells
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017705:Lignans; D010666:Phenylpropionates