Paraneoplastic antibodies coexist and predict cancer, not neurological syndrome.
We investigated coexisting autoantibodies in sera of 553 patients with a neurological presentation and one or more paraneoplastic neuronal nuclear or cytoplasmic autoantibodies: antineuronal nuclear autoantibody type 1 (ANNA-1), ANNA-2, ANNA-3; Purkinje cell cytoplasmic autoantibody type 1 (PCA-1), PCA-2; and CRMP-5-immunoglobulin G or amphiphysin-immunoglobulin G. Except for PCA-1, which occurred alone, 31% of sera had more than one of these autoantibodies. In addition, 25% of sera had neuronal calcium channel (P/Q-type or N-type), potassium channel, ganglionic acetylcholine receptor, muscle acetylcholine receptor, or striational antibodies. The autoantibody profiles observed in patients with paraneoplastic disorders imply the targeting of multiple onconeural antigens and predict the patient's neoplasm, but not a specific neurological syndrome.
Pittock
Sean J
SJ
Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Kryzer
Thomas J
TJ
Lennon
Vanda A
VA
D000974:Antibodies, Antinuclear / Q000097:blood / Q000145:classification; D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western / Q000379:methods; D001921:Brain / Q000378:metabolism; D020865:Calcium Channels, P-Type / Q000097:blood; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D006867:Hydrolases; D007074:Immunoglobulin G / Q000097:blood; D007668:Kidney / Q000378:metabolism; D008297:Male; D008869:Microtubule-Associated Proteins; D009132:Muscles / Q000378:metabolism; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000097:blood / Q000276:immunology; D020361:Paraneoplastic Syndromes, Nervous System / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D015221:Potassium Channels / Q000097:blood; D011237:Predictive Value of Tests; D011689:Purkinje Cells / Q000166:cytology / Q000276:immunology; D011950:Receptors, Cholinergic / Q000378:metabolism; D012189:Retrospective Studies
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D020865:Calcium Channels, P-Type; D007074:Immunoglobulin G; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D011950:Receptors, Cholinergic; C075637:amphiphysin; C415087:DPYSL5 protein, human; D006867:Hydrolases