Judging a virus by its cover.
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.
Szomolanyi-Tsuda
Eva
E
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Welsh
Raymond M
RM
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology; D051379:Mice; D009500:Neutralization Tests; D012367:RNA, Viral; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000276:immunology; D014771:Virion / Q000235:genetics / Q000276:immunology
D000914:Antibodies, Viral; D008562:Membrane Glycoproteins; D012367:RNA, Viral; D014759:Viral Envelope Proteins