Antiinflammatory triterpenoid saponins from the seeds of Aesculus chinensis.
Phytochemical study of the ethanol extract of the seeds of Aesculus chinensis led to the isolation of a new triterpenoid saponin (6), together with five known triterpenoid saponins (1-5). The structure of the new compound was elucidated on the basis of spectral data to be 21,28-di-O-acetylprotoaescigenin-3-O-[beta-D-glucopyranosyl(1-2)][beta-D-glucopyranosyl(1-4)]-beta-D-glucopyranosiduronic acid (aesculiside A, 6). The antiinflammatory activities of the four main saponins (1-4) were compared with those of total saponin extracts, and single saponins showed more potent activity than total saponin extracts in mice.
Wei
Feng
F
Division of Chinese Materia Medica and Natural Products, National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, Beijing, Peoples's Republic of China. hograwei@hotmail.com
Ma
Lin-Yun
LY
Jin
Wen-Tao
WT
Ma
Shuang-Cheng
SC
Han
Guo-Zhu
GZ
Khan
Ikhlas Ahmad
IA
Lin
Rui-Chao
RC
D031319:Aesculus; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014992:Xylenes / Q000009:adverse effects
C496671:21,28-di-O-acetylprotoaescigenin-3-O-(beta-D-glucopyranosyl(1-2)9beta-D-glucopyranosyl(1-4))-beta-D-glucopyranosiduronic acid; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; D014992:Xylenes