Atherosclerotic renal artery stenosis: one year outcome of total and separate kidney function following stenting.
BACKGROUND
Renal artery stenosis (RAS) is a known cause of hypertension and ischemic nephropathy. Stenting of the artery is a valid approach, in spite of cases of unexpected adverse evolution of renal function.


METHODS
In this study, 27 patients with unilateral RAS were subjected to stenting and followed for a period of one year, while 19 patients were observed while on medical treatment only. The group of 27 patients, 67.33 +/- 6.8 years of age, creatinine of 2.15 +/- 0.9 mg/dl, following stenting, were followed at intervals with biochemical tests, renal scintigraphy and doppler ultrasonography. The control group (70.0 +/- 6.1 years, creatinine 1.99 +/- 0.7 mg/dl) was also followed for one year.


RESULTS
One year after stenting mean creatinine clearance (Ccr) increased from 36.07 +/- 17.2 to 40.4 +/- 21.6 ml/min (NS). Arterial BP, decreased after 1,3,6, and 12 months (p < 0.05). The number of antihypertensive drugs also decreased (p < 0.05). A significant increase in proteinuria was also observed. In the control group both Ccr, BP and proteinuria did not show significant changes. Based on renal scintigraphy and Ccr at subsequent times, it was possible to evaluate the timecourse of renal function in both kidneys of the stented patients. In the stented kidneys Ccr increased significantly. On the controlateral kidney a decrease of renal function (p < 0.05) was observed. Resistance index appeared to be a risk factor of the functional outcome.


CONCLUSIONS
Stenting of RAS due to atherosclerosis is followed by stabilization or improvement of Ccr, mainly at the stented kidney, while contralateral renal function showed a decrease.
Renal Pathophysiology and Hypertension Unit, Dept of Medical Sciences, La Sapienza University, Rome, Italy. coen.gf@flashnet.it
Giorgio
G
Coen
Eleonora
E
Moscaritolo
Carlo
C
Catalano
Raffaella
R
Lavini
Italo
I
Nofroni
Giuseppe
G
Ronga
Daniela
D
Sardella
Alvaro
A
Zaccaria
Rosario
R
Cianci
D000368:Aged; D000800:Angioplasty, Balloon; D001161:Arteriosclerosis / Q000150:complications* / Q000628:therapy; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D011446:Prospective Studies; D012078:Renal Artery Obstruction / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D015607:Stents; D016896:Treatment Outcome
D003404:Creatinine