Synapse scaffolding: intersection of endocytosis and growth.
The Drosophila dynamin-associated protein Dap160, homolog of the vertebrate Intersectins, is thought likely to act as a molecular scaffold in the synaptic periactive zone. New mutant analyses have revealed separable roles for Dap160 in the regulation of vesicular endocytosis and synaptic growth.
Broadie
Kendal
K
Department of Biological Sciences, Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37232, USA. Kendal.Broadie@Vanderbilt.edu
D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology; D034281:Dynamins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D009479:Neuropeptides / Q000378:metabolism / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D013569:Synapses / Q000378:metabolism / Q000502:physiology*; D022161:Transport Vesicles / Q000502:physiology; D033921:Vesicular Transport Proteins
D033942:Adaptor Proteins, Vesicular Transport; C113692:Dap160 protein, Drosophila; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009479:Neuropeptides; D033921:Vesicular Transport Proteins; D034281:Dynamins