Evaluation of suitable biodegradable scaffolds for engineered bone tissue.
Tricalcium phosphate/hydroxyapatite (TCP/HA), hydroxyapatite (HA), chitosan and calcium sulphate (CaSO4) were studied and evaluated for possible bone tissue engineered construct acting as good support for osteogenic cells to proliferate, differentiate, and eventually spread and integrate into the scaffold. Surface morphology visualized by SEM showed that scaffold materials with additional fibrin had more cell densities attached than those without, depicting that the presence of fibrin and collagen fibers were truly a favourite choice of cells to attach. In comparison of various biomaterials used incorporated with fibrin, TCP/HA had the most cluster of cells attached.
Phang
M Y
MY
Institute of Bioscience, Universiti Putra Malaysia.
Ng
M H Angela
MH
Tan
K K
KK
Aminuddin
B S
BS
Ruszymah
B H I
BH
Fauziah
O
O
D001673:Biodegradation, Environmental; D016025:Bone Transplantation; D002130:Calcium Phosphates; D002133:Calcium Sulfate; D002448:Cell Adhesion / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002516:Ceramics; D048271:Chitosan; D017886:Durapatite; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009924:Organ Culture Techniques / Q000379:methods*; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
D002130:Calcium Phosphates; D048271:Chitosan; D017886:Durapatite; C018392:tricalcium phosphate; D002133:Calcium Sulfate