Epstein-Barr virus-associated peripheral T-cell lymphoma and hemophagocytic syndrome arising after liver transplantation: case report and review of the literature.
Post-transplantation lymphoproliferative disorders (PTLD) are a well-recognized complication of solid organ transplantation. The vast majority of PTLD are Epstein-Barr virus (EBV)-related infections that manifest as B-cell malignancies. We report an unusual case of an EBV-associated T-cell lymphoma in a 10-year-old boy who had previously undergone liver transplantation at age 4 years. He presented with hemophagocytic syndrome (HPS) and active EBV infection, with positive serum titers and polymerase chain reaction (PCR) for EBV in blood, colon, and antral samples.
George
Tracy I
TI
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA. tigeorge@stanford.edu
Jeng
Michael
M
Berquist
William
W
Cherry
Athena M
AM
Link
Michael P
MP
Arber
Daniel A
DA
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000209:etiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology*; D006801:Humans; D016130:Immunophenotyping; D016031:Liver Transplantation; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications