Health effects of diazinon on a family.
There is increasing evidence of permanent sequalae from acute organophosphate poisoning. We report on accidental diazinon overexposure with acute organophosphate poisoning through cutaneous absorption and inhalation followed by persistent neurological effects. In addition, we observed skeletal and endocrine effects likely attributable to the diazinon poisoning. A family of seven was exposed to diazinon in June 1999 over a two-day period. The pesticide company mistakenly used diazinon to heavily spray the inside of the home instead of permethrin. The applicator applied the pesticide over the entire surface of the floor, carpeting, furniture, and clothing in closets to eradicate an infestation of fleas. Acute symptoms in the family members included headaches, nausea, skin irritation, runny nose, and vomiting. The family was first evaluated at 3 months and then 3 years after the acute poisoning. There were persisting neurological symptoms of memory loss, decreased concentration, irritability, and personality changes of varying degrees in all family members. Objective neurological findings of impaired balance, reaction time, color vision, slotted pegboards and trials making were present in the three older children who could be tested. Neuropsychological evaluation revealed evidence of organic brain dysfunction in all seven family members. Bone growth difficulties are present in four of five children. One child has delayed menarche.
UCLA School of Medicine, 2811 Wilshire Blvd. Suite 510, Santa Monica, CA 90403, USA. Dahlgren@envirotoxicology.com
J G
JG
Dahlgren
H S
HS
Takhar
C A
CA
Ruffalo
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M
Zwass
D000328:Adult; D000388:Air / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003976:Diazinon / Q000032:analysis / Q000493:pharmacokinetics / Q000506:poisoning*; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007223:Infant; D019570:Inhalation Exposure / Q000009:adverse effects / Q000032:analysis; D007306:Insecticides / Q000032:analysis / Q000493:pharmacokinetics / Q000506:poisoning*; D007509:Irritants; D008297:Male; D009483:Neuropsychological Tests; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000523:psychology; D011247:Pregnancy; D012220:Rhinitis / Q000139:chemically induced; D012869:Skin Absorption; D014839:Vomiting / Q000139:chemically induced
D007306:Insecticides; D007509:Irritants; D003976:Diazinon