Efficient and selective removal of methoxy protecting groups in carbohydrates.
[reaction: see text] The selective removal from carbohydrate substrates of methoxy protecting groups next to hydroxy groups is reported. On treatment with PhI(OAc)(2)-I(2), the methoxy group is transformed into an easily removable acetal. The mild conditions of this methodology are compatible with many functional groups, and good to excellent yields are usually achieved.
Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez 3, 38206-La Laguna, Tenerife, Spain. alicia@ipna.csic.es
Alicia
A
Boto
Dácil
D
Hernández
Rosendo
R
Hernández
Ernesto
E
Suárez
D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*
D002241:Carbohydrates