Association of the mitochondrial DNA haplogroup J with longevity is population specific.
Evidences are accumulating on the effects of the variability of mitochondrial DNA (mtDNA) on many complex traits. In particular, mtDNA haplogroup J has been reported to increase the individual chance to attain longevity in northern Italians, Northern Irish and Finns. However, since the genetic contribution to longevity may be population specific, we wanted to verify if haplogroup J does affect longevity also in a southern European population having a different genetic and environmental history. We analysed a population sample (883 subjects, 371 males and 521 females; age range 18-108 years) from southern Italy for the presence of haplogroup J. No frequency increase of this mtDNA haplogroup was found in the older cohorts, suggesting that, in this population, haplogroup J does not play a significant role in longevity. This finding shows that, as for other genetic factors, the association of mtDNA inherited variability with longevity is population specific.
Department of Cell Biology, University of Calabria, Rende, Italy.
Serena
S
Dato
Giuseppe
G
Passarino
Giuseppina
G
Rose
Katia
K
Altomare
Dina
D
Bellizzi
Vincenzo
V
Mari
Emidio
E
Feraco
Claudio
C
Franceschi
Giovanna
G
De Benedictis
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004272:DNA, Mitochondrial; D005260:Female; D006239:Haplotypes; D006801:Humans; D007558:Italy; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics*
D004272:DNA, Mitochondrial