Bone marrow metastasis of angiosarcoma.
We report a rare finding of bone marrow metastasis from an angiosarcoma. The patient was a 36-year-old man who initially presented with a high-grade angiosarcoma of the spleen and was treated with splenectomy and chemotherapy. He developed leukoerythroblastic anemia three years after splenectomy. Bone marrow biopsy revealed extensive infiltrate by angiosarcoma with typical features of spindle tumor cells and anastomosing vascular channels. The immunohistochemistry showed tumor cells positive for the endothelial markers of CD31, CD34, and von Willebrand factor. Angiosarcomas are rare and aggressive tumors. Although metastases occur commonly, bone marrow findings have been rarely documented. We have found in the literature two other cases of bone marrow metastasis of angiosarcoma, and all these patients had a primary tumor of the spleen. It would seem that splenic angiosarcomas have a virtually unique propensity for infiltration in the bone marrow.
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, 600 University Av., Toronto, Canada M5G 1X5. cwang@mtsinai.on.ca
Chen
C
Wang
Rola
R
Rabah
Martin
M
Blackstein
Robert H
RH
Riddell
D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D001706:Biopsy; D019046:Bone Marrow Neoplasms / Q000737:chemistry / Q000473:pathology / Q000556:secondary*; D006394:Hemangiosarcoma / Q000737:chemistry / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D013160:Splenic Neoplasms / Q000473:pathology*; D014841:von Willebrand Factor / Q000032:analysis
D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014841:von Willebrand Factor