Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation.
The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the cervical lymph nodes, tonsils, and adenoids that was manifested as granulocytic sarcoma. Following chemotherapy, the patient underwent a conditioning regimen of busulfan, cyclophosphamide, and total body irradiation followed by successful allogeneic bone marrow transplantation from her single HLA locus-mismatched mother at 6 months after her diagnosis. The patient continues to be well and in remission 3 years after stem cell transplantation.
Imamura
Toshihiko
T
Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Osaka, Japan. imamura@koto.kpu-m.ac.jp
Matsuo
Satoshi
S
Yoshihara
Takao
T
Chiyonobu
Tomohiro
T
Mori
Kanako
K
Ishida
Hiroyuki
H
Nishimura
Yasutaka
Y
Kasubuchi
Yasuo
Y
Naya
Mayumi
M
Morimoto
Akira
A
Hibi
Shigeyoshi
S
Imashuku
Shinsaku
S
D000234:Adenoids / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000379:methods*; D002648:Child; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008198:Lymph Nodes / Q000473:pathology; D014066:Palatine Tonsil / Q000473:pathology; D011859:Radiography; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome