Two classic papers in acid-base physiology: contributions of R. F. Pitts, R. S. Alexander, and W. D. Lotspeich.
This essay looks at the historical significance of two APS classic papers that are freely available online: Pitts RF and Alexander RS. The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144: 239-254, 1945 (http://ajplegacy.physiology.org/cgi/reprint/144/2/239). Pitts RF and Lotspeich WD. Bicarbonate and the renal regulation of acid base balance. Am J Physiol 147: 138-154, 1946 (http://ajplegacy.physiology.org/cgi/reprint/147/1/138).
Dept. of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8026, USA. Gerhard.giebisch@yale.edu
Gerhard
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Giebisch
D000136:Acid-Base Equilibrium / Q000502:physiology*; D000138:Acidosis / Q000503:physiopathology; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D049673:History, 20th Century; D007668:Kidney / Q000502:physiology*; D007684:Kidney Tubules / Q000378:metabolism / Q000502:physiology; D010827:Physiology / Q000266:history*; D014556:Urine / Q000502:physiology
D001639:Bicarbonates