[Study on the polymorphism of interleukin-1 gene and the susceptibility to essential hypertension].
OBJECTIVE
To make investigations on the polymorphism of interleukin-1 (IL-1)gene in Chinese Han population, on its association with essential hypertension, and on the relationship between the genotype of IL-1 and susceptibility to essential hypertension.


METHODS
The polymorphisms of IL-1 gene in Han population of Hubei province, including polymorphisms of IL-1alpha (-889C/T), IL-1beta (-511C/T),IL-1beta (+3953C/T), IL-1Ra(+8006T/C) and IL-1Ra (variable number of tandem repeat, VNTR), were analyzed by polymerase chain reaction (PCR) and a combination of PCR-restriction fragment length polymorphism methods in 152 patients with essential hypertension and 168 healthy controls.


RESULTS
The polymorphism distributions of IL-1alpha (-889C/T), IL-1beta (+3953C/T), IL-1Ra (+8006T/C) and IL-1Ra (VNTR) showed no differences between the essential hypertension group and control group, but the IL-1beta (-511C/T) exhibited a significant difference between the two groups. CT genotype carriers were at increased risk for essential hypertension (OR=2.54, 95%CI: 1.41-4.58), compared with healthy controls.


CONCLUSIONS
The polymorphism of promotor region -511C/T in IL-1beta gene is probably associated with the susceptibility to essential hypertension.
Department of Clinical Laboratory Science, Renmin Hospital of Wuhan University, Wuhan, Hubei,430060 P.R. China.
Yan
Y
Li
Pu
P
Xu
Ping-an
PA
Zhang
Xiao-yan
XY
Li
Cong-xin
CX
Huang
D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
D053590:Interleukin 1 Receptor Antagonist Protein; D053582:Interleukin-1alpha; D053583:Interleukin-1beta