Resistive training and chromium picolinate: effects on inositols and liver and kidney functions in older adults.
This study assessed the effects of resistive training (RT) with or without chromium picolinate (Cr-pic) supplementation on the 24-h urinary excretions of myo-inositol, D-chiro-inositol, and pinitol, as well as clinical indices of kidney and liver functions. Thirty-two nondiabetic subjects, age 62 +/- 4 y, performed RT twice weekly for 12 wk and consumed either 924 ug Cr/d as Cr-pic (n = 17) or a placebo (n = 15). Whole-body strength increased in all subjects by 20 % and urinary chromium excretion increased 47-fold in the Cr-pic group. Urinary myo-inositol, D-chiro-inositol, and pinitol were not changed with RT or influenced by Cr-pic. Serum indices of kidney and liver functions were within clinically normal ranges at baseline and the end of the study. These results suggest that RT did not influence the urinary excretions of inositols. High dose Cr-pic did not influence the urinary excretion of inositols and the selected indices of kidney and liver functions in conjunction with RT.
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA.
Wayne W
WW
Campbell
Lyndon J O
LJ
Joseph
Richard E
RE
Ostlund
Richard A
RA
Anderson
Peter A
PA
Farrell
William J
WJ
Evans
D019540:Area Under Curve; D001774:Blood Chemical Analysis; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007294:Inositol / Q000652:urine*; D007502:Iron Chelating Agents / Q000378:metabolism / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects; D010848:Picolinic Acids / Q000494:pharmacology* / Q000652:urine; D012737:Sex Factors; D014891:Weight Lifting / Q000502:physiology
D007502:Iron Chelating Agents; D010848:Picolinic Acids; D007294:Inositol; C030614:picolinic acid