Effect of cyclohexenonic long-chain fatty alcohol on rat overactive bladder induced by bladder neck obstruction.
We attempted to clarify the preventive effects of cyclohexenonic long-chain fatty alcohol on detrusor overactivity induced by mild bladder neck obstruction. Bladder neck obstruction was created by partial ligation of the urethra. Female Sprague-Dawley rats were divided into three groups: those with bladder neck obstruction treated without long-chain fatty alcohol, those with bladder neck obstruction with long-chain fatty alcohol (8 mg/kg, i.p., every day) and the sham-operated control group (A, B, and C groups, respectively). Six weeks after the induction of bladder neck obstruction, voiding behavior was observed in the metabolic cage, and a cystometrogram was performed in the experimental animals. Furthermore, Hematoxylin and Eosin, Azan-Mallory, and Bodian stainings were performed in these bladders. Bladder weight, voiding behaviors and a cystometry indicated that rats in the A group showed detrusor overactivity, which was improved by treatment with long-chain fatty alcohol. The proportion of connective tissue and the density of bundles of neurofibers in the bladder of the A group was significantly less than that in the other bladders. Mild bladder neck obstruction induces detrusor overactivity, which is improved by treatment with long-chain fatty alcohol.
Department of Surgery, Division of Urology, Tottori University Faculty of Medicine, 36-1 Nishimachi, Yonago 683-0826 Japan. saitomo@grape.med.tottori-u.ac.jp
Motoaki
M
Saito
Hiroto
H
Suzuki
Masashi
M
Yamada
Katsuya
K
Hikita
Naoto
N
Kobayashi
Yukako
Y
Kinoshita
Daisuke
D
Houri
Ikuo
I
Miyagawa
Keisuke
K
Satoh
D000818:Animals; D003512:Cyclohexanones / Q000737:chemistry / Q000627:therapeutic use*; D005233:Fatty Alcohols / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy* / Q000473:pathology; D014549:Urinary Incontinence / Q000188:drug therapy* / Q000473:pathology
D003512:Cyclohexanones; D005233:Fatty Alcohols