Maintaining integrity.
Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland. Top
The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. yossih@post.tau.ac.il <yossih@post.tau.ac.il>
Yosef
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Shiloh
Alan R
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Lehmann
D000818:Animals; D018385:Centrosome; D002869:Chromosome Aberrations; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D030342:Genetic Diseases, Inborn / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000209:etiology / Q000235:genetics; D042822:Genomic Instability / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D011371:Progeria / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction