The effect of mannan-binding lectin variant alleles on coronary artery reactivity in healthy young men.
Mannan-binding lectin (MBL) is a serum acute-phase protein and a complement component secreted by the liver. Its deficiency caused by point mutations in the MBL gene has recently been associated with severe atherosclerosis. In this study, we investigated the effect of MBL variant alleles on coronary artery reactivity, which is an early marker of coronary dysfunction and predicts the development of atherosclerosis and coronary artery disease. The study population consisted of 51 apparently healthy, normo- or mildly hypercholesterolemic young men. Myocardial blood flow was measured at baseline and during adenosine-induced hyperemia with positron emission tomography (PET), and MBL genotyping was performed using restriction fragment-length polymorphism. As a result, MBL variant alleles had no effect on coronary artery reactivity. This finding suggests that MBL deficiency is not an independent risk factor for coronary dysfunction and early atherogenic changes but rather a co-factor in the development of atherosclerosis. Thus, the connection of MBL variant alleles with environmental risk factors in atherosclerosis should further be assessed.
Janne
J
Aittoniemi
Yue-Mei
YM
Fan
Reijo
R
Laaksonen
Tuula
T
Janatuinen
Risto
R
Vesalainen
Pirjo
P
Nuutila
Juhani
J
Knuuti
Janne
J
Hulkkonen
Mikko
M
Hurme
Terho
T
Lehtimäki
D000328:Adult; D000483:Alleles; D002306:Cardiac Volume / Q000235:genetics*; D003326:Coronary Circulation / Q000235:genetics*; D003331:Coronary Vessels / Q000502:physiology*; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D012016:Reference Values
D037601:Mannose-Binding Lectin