The evolution of molecular biology into systems biology.
Systems analysis has historically been performed in many areas of biology, including ecology, developmental biology and immunology. More recently, the genomics revolution has catapulted molecular biology into the realm of systems biology. In unicellular organisms and well-defined cell lines of higher organisms, systems approaches are making definitive strides toward scientific understanding and biotechnological applications. We argue here that two distinct lines of inquiry in molecular biology have converged to form contemporary systems biology.
Westerhoff
Hans V
HV
Department of Molecular Cell Physiology, BioCentrum Amsterdam, De Boelelaan 1085, NL-108, HV Amsterdam, the Netherlands. hw@bio.vu.nl
Palsson
Bernhard O
BO
D001698:Biomedical Engineering / Q000266:history*; D023281:Genomics / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D008954:Models, Biological; D008967:Molecular Biology / Q000266:history*; D049490:Systems Biology / Q000266:history*