Impairment of recognition memory in schizophrenia: event-related potential study using a continuous recognition task.
Recognition memory and the dissociation of immediate and delayed repetition in schizophrenic patients were investigated using event-related potential (ERP) and a continuous word recognition task. In total, 14 schizophrenic patients and 14 age and gender-matched control subjects, were recruited. Among 240 stimulus words used, 40 words were not repeated, 100 were repeated immediately, and 100 were repeated after five intervening words. Both schizophrenic and control groups responded faster to words repeated immediately than to words repeated after a delay and to new words. However, schizophrenic patients responded less accurately to words repeated immediately and to words repeated after a delay than the controls. In terms of ERP, schizophrenic patients showed significantly reduced N200, late positive component (LPC), and N400 amplitudes, and a more frontally-distributed N200 topography than the controls. For controls, immediate repetition was associated with a large LPC amplitude and the absence of N400, while delayed repetition was associated with a small LPC amplitude and the presence of N400. However, this dissociation between immediate and delayed repetition was not observed in schizophrenic patients. All of these results suggest that schizophrenic patients have recognition memory impairment, the cause of which may range from early encoding, and memory search to late retrieval.
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Myung-Sun
MS
Kim
Jun Soo
JS
Kwon
Seung-Suk
SS
Kang
Tak
T
Youn
Kyung-Whun
KW
Kang
D000328:Adult; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012153:Retention, Psychology / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014706:Verbal Learning / Q000502:physiology*