Are there genetic influences on sporadic brain arteriovenous malformations?
The genesis of brain arteriovenous malformations remains enigmatic. We reviewed some pathways involving inflammatory and angiogenic signals that are amenable to the study of genetic single-nucleotide polymorphisms associated with the sporadic disease. Such study can yield insights into arteriovenous malformation pathogenesis and suggest possible fruitful approaches to developing medical therapy. Moreover, single-nucleotide polymorphisms identification would provide targets for risk stratification for planning clinical trials and eventually guiding management.
Young
William L
WL
Department of Anesthesia, Center for Cerebrovascular Research, Neurological Surgery, and Neurology, University of California San Franscisco, 1001 Potrero Ave, Box 1371 San Francisco, CA 94110, USA. ccr@anesthesia.ucsf.edu
Yang
Guo-Yuan
GY
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000235:genetics*; D020300:Intracranial Hemorrhages / Q000209:etiology / Q000235:genetics* / Q000517:prevention & control; D020641:Polymorphism, Single Nucleotide; D012306:Risk