[Psychotropics and weight gain].
Weight overload and obesity became these last years a major health problem. However gain weight is a frequent side effect of a large number of psychotropics. This article proposes to discuss this potential while reviewing various molecules. This reveals that the atypical antipsychotics are most likely to induce weight gain, in particular clozapine and olanzapine. The tricyclic antidepressants and mirtazapine come next, with the majority of the mood stabilizers. The old antipsychotics seem to involve less gain of weight. The SSRI make lose weight in the first weeks of treatment, but induce a moderate weight gain on the long term.
Sahli
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Secteur Psychiatrique Ouest, Hôpital Psychiatrique de Prangins.
Bryois
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D000293:Adolescent; D000328:Adult; D000077582:Amisulpride; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D018692:Antimanic Agents / Q000008:administration & dosage / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D000068180:Aripiprazole; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects; D015992:Body Mass Index; D002648:Child; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D009765:Obesity / Q000139:chemically induced*; D000077152:Olanzapine; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects; D010919:Placebos; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects*; D000069348:Quetiapine Fumarate; D015363:Quinolones / Q000008:administration & dosage / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects; D012959:Socioeconomic Factors; D013469:Sulpiride / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D013844:Thiazoles / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors; D000077236:Topiramate; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects; D015430:Weight Gain
D000928:Antidepressive Agents; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D007093:Imidazoles; D007211:Indoles; D010879:Piperazines; D010919:Placebos; D011619:Psychotropic Drugs; D015363:Quinolones; D013844:Thiazoles; D000077236:Topiramate; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D005632:Fructose; D014635:Valproic Acid; C092292:ziprasidone; D013469:Sulpiride; D000077582:Amisulpride; D000068180:Aripiprazole; C066304:sertindole; D003024:Clozapine; D006220:Haloperidol; D018967:Risperidone; D000077152:Olanzapine