Aggressive pharmacological treatment for reversing malignant bowel obstruction.
Early and intensive pharmacological treatment not only may reduce gastrointestinal symptoms but also reverse malignant bowel obstruction. Fifteen consecutive advanced cancer patients with inoperable bowel obstruction received a combination of drugs including metoclopramide, octreotide, dexamethasone and an initial bolus of amidotrizoato. Recovery of intestinal transit was reported within 1-5 days in fourteen patients, who continued this treatment without presenting symptoms of bowel obstruction until death. This case series establishes that the combination of propulsive and antisecretive agents can act synergistically to allow a fast recovery of bowel transit without inducing unpleasant colic. It suggests that the most important mechanism in these circumstances is functional and can be reversible, if an aggressive treatment is initiated early before fecal impaction and edema render bowel obstruction irreversible.
Mercadante
Sebastiano
S
Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy.
Ferrera
Patrizia
P
Villari
Patrizia
P
Marrazzo
Antonio
A
D000008:Abdominal Neoplasms / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage*; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D006801:Humans; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D010386:Pelvic Neoplasms / Q000150:complications / Q000188:drug therapy*; D020127:Recovery of Function / Q000187:drug effects; D013727:Terminal Care / Q000379:methods; D016896:Treatment Outcome
D000932:Antiemetics; D004338:Drug Combinations; D005765:Gastrointestinal Agents