Prognostic use of mean ovarian volume in in vitro fertilization cycles: a prospective assessment.
OBJECTIVE
To determine the predictive value and to define prognostic threshold measurements for mean ovarian volume (MOV) in patients undergoing IVF.


METHODS
Prospective cohort analysis.


METHODS
Tertiary care center.


METHODS
Two hundred sixty-seven patients.


METHODS
Transvaginal ultrasound before starting gonadotropins.


METHODS
Number of oocytes retrieved, basal hormone levels, and cycle outcomes.


RESULTS
The MOV for the population was 4.78 +/- 2.6 cm(3) (range 0.9-21.1 cm(3)). The MOV significantly correlated with the majority of prestimulation and poststimulation IVF parameters. Threshold analysis demonstrated a lower pregnancy rate associated with a MOV of <2 cm(3) (31.6% vs. 55.6%). Threshold analysis revealed a trend toward higher cancellation rate associated with a MOV of <2 cm(3) (21.1% vs. 7.3%).


CONCLUSIONS
Although MOV correlated with IVF stimulation parameters, its use as an adjunct in counseling patients during IVF appears to be of limited value. A MOV <2 cm(3) was associated clinically with a higher cancellation rate (21.1%) and a lower pregnancy rate (31.6%) in those cycles not cancelled. However, these values do not deviate far from the mean national IVF outcome rates. There was no absolute MOV that was predictive of pregnancy outcome or cycle cancellation.
Frattarelli
John L
JL
Tripler Army Medical Center, Honolulu, Hawaii 96859-5000, USA. john.frattarelli@amedd.army.mil
Levi
Andrew J
AJ
Miller
Bradley T
BT
Segars
James H
JH
D015331:Cohort Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009865:Oocytes / Q000502:physiology; D010053:Ovary / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D014463:Ultrasonography
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone