Worsening fluid retention in a patient with hereditary angioedema and end-stage renal disease.
A 60-year-old woman who was diagnosed with hereditary angioedema (HAE) developed nephrotic syndrome, with end-stage renal disease (ESRD) occurring about 2.5 years later. During her slide toward ESRD, she experienced three severe episodes of angioedema that each resulted in significant fluid retention. Though the therapeutic administration of C1-inhibitor concentrate was effective in controlling her angioedema, seemed ineffective in preventing her from developing ESRD requiring hemodialysis treatment. We theorized that the patient's low colloid osmolality and glomerular perfusion were important facilitators of her attacks of angioedema.
Internal Medicine II, Nihon University School of Medicine, Tokyo.
Isao
I
Ohsawa
Atsushi
A
Satomura
Yoshinobu
Y
Fuke
Mutsuko
M
Hidaka
Morito
M
Endo
Takayuki
T
Fujita
Hiroyuki
H
Ohi
D000799:Angioedema / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; D004487:Edema / Q000209:etiology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology; D015843:Serpins / Q000627:therapeutic use
D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; D004791:Enzyme Inhibitors; C469952:SERPING1 protein, human; D015843:Serpins