Coughing in pre-school children in general practice: when are RAST's for inhalation allergy indicated?
To identify patterns of clinical history associated with extreme (high or low) probabilities of allergic sensitization in coughing children so as to restrict allergy testing to those with an intermediate probability of sensitization. A total of 752 children, aged 1-4, visiting their GPs for coughing (>or=5 days), were tested for IgE-antibodies to house dust mite, cat and dog [RadioAllergoSorbent Test (RAST)]. Parents completed a questionnaire on family history of atopy, breastfeeding, smoking, pets, and floor covering. Data of 640 children could be analyzed, 83 (13%) were IgE-positive. In a logistic regression analysis, a scoring formula for the prediction of being IgE-positive was constructed using variables from the patient's history. Significant contributors for sensitization were: age (3-4 yr), infantile eczema, positive family history of mite-allergy, sibling(s) with pollen-allergy, and smoking by parents. If only one of these characteristics is present, the probability of sensitization is < 25%. In such cases watchful waiting may be preferred over allergy testing. In other cases, a negative RAST may help to exclude sensitization, whereas a positive RAST helps to establish the diagnosis. Thus, acting on clinical history alone may save approximately 80% of RAST's. Patient history-derived information contributes to distinguishing children who are at low risk for sensitization to house dust mite, cat, and dog. The scoring formula may help GPs to identify children with a low probability of being sensitized. This may form the basis for watchful waiting. In others, allergy testing may be useful to gain more diagnostic certainty.
Department of General Practice, Division Clinical Methods and Public Health, Academic Medical Center - University of Amsterdam, Amsterdam, The Netherlands.
Petra E D
PE
Eysink
Ben J A M
BJ
Bottema
Gerben
G
ter Riet
Rob C
RC
Aalberse
Steven O
SO
Stapel
Patrick J E
PJ
Bindels
D000485:Allergens / Q000276:immunology; D002675:Child, Preschool; D003371:Cough / Q000209:etiology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis*; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D019570:Inhalation Exposure; D008297:Male; D015233:Models, Statistical; D011852:Radioallergosorbent Test; D012307:Risk Factors; D011795:Surveys and Questionnaires
D000485:Allergens; D007073:Immunoglobulin E