Persistence of parvovirus B19 IgM antibodies and DNA in pure red cell aplasia resulting in myelodysplasia--a case report.
Human erythrovirus B19 (B19), previously known as parvovirus B19, is a small spherical, non-enveloped single stranded DNA virus. It has been shown to cause a wide spectrum of clinical conditons including various hematological disorders. We report here for the first time from Inida a case of pure red cell aplasia in a 45-year-old female for last 7 years due to chronic persistent B19 infection leading to myelodysplasia after 4 years. Her sera were positive for two times 4 months apart for B19 IgM and B19 DNA at the initial stage. Presently the patient is on repeated blood transfusion on every 15-20 days.
Kishore
J
J
Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow. janak@sgpgi.ac.in
Mukhopadhyay
C
C
D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008875:Middle Aged; D009436:Neural Tube Defects / Q000209:etiology / Q000276:immunology / Q000821:virology*; D010322:Parvoviridae Infections / Q000150:complications / Q000276:immunology / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D012010:Red-Cell Aplasia, Pure / Q000276:immunology / Q000821:virology*
D000914:Antibodies, Viral; D004279:DNA, Viral; D007075:Immunoglobulin M