Neurotrophin action on a rapid timescale.
Mechanisms underlying the fast action of neurotrophins include intracellular Ca(2+) signaling, neuronal excitation, augmentation of synaptic excitation by modulation of N-methyl-d-aspartate receptor activity and control of synaptic inhibition through the regulation of the K(+)-Cl(-) cotransporter KCC2. The fastest action of brain-derived neurotrophic factor and neurotrophin-4/5 occurs within milliseconds, and involves activation of TrkB and the opening of the Na(+) channel Na(v)1.9. Through these rapid actions, neurotrophins shape neuronal activity, modulate synaptic transmission and produce instructive signals for the induction of long-term changes in the efficacy of synaptic transmission.
Kovalchuk
Yury
Y
Institut für Physiologie, Ludwig-Maximilians-Universität München, 80336 München, Germany.
Holthoff
Knut
K
Konnerth
Arthur
A
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D002490:Central Nervous System / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D013570:Synaptic Membranes / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D013997:Time Factors
D007473:Ion Channels; D009414:Nerve Growth Factors