Glomerular filtration of albumin: how small is the sieving coefficient?
A model was developed to describe how the concentration of albumin in proximal tubule fluid will vary with axial position, including the effects of luminal flow and water and albumin reabsorption. The results show that the high albumin sieving coefficients proposed recently cannot be reconciled with micropuncture data in rats.
Deen
William M
WM
Department of Chemical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. wmdeen@mit.edu
Lazzara
Matthew J
MJ
D000419:Albuminuria / Q000378:metabolism*; D000818:Animals; D005919:Glomerular Filtration Rate; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008954:Models, Biological; D012709:Serum Albumin / Q000378:metabolism
D012709:Serum Albumin