[Viagra effects on polysystemic energy metabolism in stress (an experimental study)].
Experiments on 40 white rats were made to study effects of cardura (doxasozine) and viagra on polysystemic energy metabolism in stress. All the animals were examined for cytochemical activity of succinate dehydrogenase, lactate dehydrogenase in blood lymphocytes, antioxidant activity of blood plasm, levels of hydroperoxides, malonic dialdehyde. 3-hour immobilization raises functional activity of mitochondria manifesting with intensification of energy metabolism. Adrenoreceptors blockade by cardura prevents changes in the cellular metabolism. The same antistress effect is observed in viagra action. This newly discovered mechanism may prevent complications of adrenergic reactions accompanying sexual intercourse.
E L
EL
Vishnevskiĭ
V S
VS
Sukhorukov
D Iu
DIu
Pushkar'
E I
EI
Shabel'nikova
A E
AE
Vishnevskiĭ
A N
AN
Koval'
D000818:Animals; D017292:Doxazosin / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008214:Lymphocytes / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D051381:Rats; D000068677:Sildenafil Citrate; D013312:Stress, Physiological / Q000201:enzymology / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000032:analysis; D013450:Sulfones
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D017292:Doxazosin