[Amiodarone-associated thyroid dysfunction: prevalence and possibilities of correction].
During 1 year of amiodarone intake development of amiodarone-associated thyroid dysfunction was observed in 25% of patients (hypothyroidism and thyrotoxicosis in 19.2 and 5.8%, respectively). Development of hypothyroidism was not accompanied with loss of antiarrhythmic efficacy of amiodarone and therapy with L-thyroxin was conducted at the background of continued amiodarone intake. In all patients with clinical and in less than one half (47.6%) of patients with subclinical forms of hypothyroidism replacement therapy with L-thyroxin was carried out. Development of amiodarone-associated thyrotoxicosis was accompanied with loss of antiarrhythmic efficacy of amiodarone in all cases. In all patients with thyrotoxicosis which developed during amiodarone intake thyrostatic therapy with mercasolil was carried out and in case of its inefficacy prednisolone was added. In 87.5% of patients with thyrotoxicosis correction of the thyroid status was conducted under conditions of continued amiodarone intake as this drug had been prescribed because of life saving indications. Achievement of euthyroid state was followed by restoration of antiarrhythmic efficacy of amiodarone. Amiodarone was discontinued just in 1 patient with ventricular extrasystole as correction of thyroid status and restoration of euthyroidosis enabled effective use of other antiarrhythmic drugs.
Serdiuk
S E
SE
Bakalov
S A
SA
Soboleva
V A
VA
Golitsin
S P
SP
Molashenko
N V
NV
Platonova
N M
NM
Sviridenko
N Iu
NIu
D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000188:drug therapy; D007037:Hypothyroidism / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D015995:Prevalence; D013959:Thyroid Diseases / Q000139:chemically induced* / Q000188:drug therapy; D013974:Thyroxine / Q000627:therapeutic use; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D000893:Anti-Inflammatory Agents; D013956:Antithyroid Agents; D008713:Methimazole; D011239:Prednisolone; D000638:Amiodarone; D013974:Thyroxine