An analogue of adenine that forms an "A:T" base pair of comparable stability to G:C.
The heterocyclic base 7-aminopropargyl-7-deaza-2,6-diaminopurine (D) has been incorporated into oligodeoxynucleotides. D:T has similar thermodynamic stability to G:C and is a stable analogue of A:T.
School of Chemistry, University of Southampton, Highfield, Southampton, UK SO17 1BJ.
James
J
Booth
W Jon
WJ
Cummins
Tom
T
Brown
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry; D020029:Base Pairing; D001483:Base Sequence; D003596:Cytosine / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D013816:Thermodynamics; D013941:Thymine / Q000737:chemistry*
D006147:Guanine; D003596:Cytosine; D000225:Adenine; D013941:Thymine