Methadone-induced torsade de pointes in a patient with normal baseline QT interval.
Torsade de pointes (TdP) is a life threatening cardiac arrhythmia that is typically associated with prolongation of the QT interval. A wide variety of nonantiarrthymic medications may trigger TdP in patients with prolonged QT interval, only a few reports have described an association between TdP and methadone. We report a case of TdP caused by a large dose of methadone in a patient with presumably normal QT interval at baseline prior to his presentation at the hospital.
Almehmi
Ammar
A
Dept. of Medicine, West Virginia University School of Medicine, Charleston Division, USA.
Malas
Amer M
AM
Yousufuddin
Mohammed
M
Rosencrance
J Gregory
JG
D000701:Analgesics, Opioid / Q000009:adverse effects*; D004554:Electric Countershock; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008691:Methadone / Q000009:adverse effects*; D008875:Middle Aged; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
D000701:Analgesics, Opioid; D008691:Methadone