Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol.
Crystallization of pindolol from the melt was studied by differential scanning calorimetry (DSC) and polarized light thermomicroscopy (PLTM) in order to discriminate the polymorphic forms obtained by this method. The crystallization process originates one exothermic signal localized in two different well-defined temperature ranges. Fusion gives rise to overlapped curves, which were analysed by peak-fitting. The polymorphs were identified as the clusters formed with the values obtained for T(peak) of the component curves. Three polymorphic forms were exhibited by pindolol crystallized from the melt. Commercial pindolol presents only two of these forms.
Nunes
Sandra C C
SC
Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal.
Eusébio
M Ermelinda
ME
Leitão
M Luísa P
ML
Redinha
J S
JS
D002152:Calorimetry, Differential Scanning / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003460:Crystallization / Q000379:methods; D008859:Microscopy, Polarization / Q000379:methods; D015394:Molecular Structure; D010869:Pindolol / Q000737:chemistry*; D011110:Polymorphism, Genetic; D013237:Stereoisomerism; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
D010869:Pindolol