[Signal transduction pathways and transcription factors involved in luteinizing hormone beta subunit gene expression].
The pulsatile pattern of the hypothalamic hormone gonadotropin-releasing hormone (GnRH) plays a critical role in reproductive function by regulating the biosynthesis and secretion of the pituitary gonadotropins. Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) are heterodimeric glycoproteins composed of a common peptide, the glycoprotein hormone subuint alpha, and either a specific FSHbeta or LHbeta polypeptide. GnRH regulates LHbeta gene expression through GnRH receptor activation of the protein kinase C (PKC) and calcium signaling cascades. Recently, many transcription factors, such as early growth response-1 (Egr-1), steroidogenic factor-1 (SF-1), Ptx1 and Sp1, have been recognized to be involved in expression of the LHbeta gene through binding to the promoter region of LHbeta gene.
Li
Lian
L
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095.
Wang
Gen-Lin
GL
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005786:Gene Expression Regulation; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000235:genetics* / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D011966:Receptors, LHRH / Q000235:genetics; D015398:Signal Transduction; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*
C515057:NR5A1 protein, human; D011966:Receptors, LHRH; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D011493:Protein Kinase C; D002118:Calcium