Molting, enzymes and new targets for chemotherapy of Onchocerca volvulus.
Parasitic nematodes do not multiply in definitive hosts, but they do molt, grow and mature for a certain period after infection, after which they devote their energies almost entirely to egg production. In this review, Sara Lustigman describes key metabolic enzymes that are essential to the development of the larval stages of Onchocerca volvulus in the host, making them potential therapeutic targets.
Lustigman
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Department of Virology and Parasitology, The Lindsley F. Kimball Research Institute o f the New York Blood Center, 310 East 67th Street, New York, NY 10021, USA.