Helicobacter pylori seroprevalence in patients with lung cancer.
OBJECTIVE
To assess Helicobacter pylori (H pylori) seroprevalence in a cohort of Greek patients with lung cancer.


METHODS
Seventy-two lung cancer patients (55 males and 17 females, aged 58.2+/-11.7 years) and 68, age and gender-matched, control subjects were enrolled. All subjects underwent an enzyme-linked immunosorbent assay IgG serologic test for H pylori diagnosis.


RESULTS
A correlation between age and H pylori IgG level was detected for both lung cancer patients (r = 0.42, P = 0.004) and controls (r = 0.44, P = 0.004). Seropositivity for H pylori did not differ significantly between patients with lung cancer and controls (61.1% vs 55.9%, P>0.05). Concerning the mean serum concentration of IgG antibodies against H pylori, no significant difference between the two groups was detected (32.6+/-19.1 vs 27.4+/-18.3 U/mL, P>0.05).


CONCLUSIONS
No significant association between H pylori infection and lung cancer was found.
9th Department of Pulmonary Medicine, SOTIRIA Chest Diseases Hospital, 152 Mesogion Street, PO Box 11527, Athens, Greece. roumar26@yahoo.com
Nikiphoros
N
Philippou
Panagiotis
P
Koursarakos
Evgenia
E
Anastasakou
Vasiliki
V
Krietsepi
Stavroula
S
Mavrea
Anastasios
A
Roussos
Dionissia
D
Alepopoulou
Irineos
I
Iliopoulos
D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006115:Greece / Q000453:epidemiology; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G