Gastrointestinal stromal tumor of the stomach with rhabdoid phenotype: immunohistochemical, ultrastructural, and immunoelectron microscopic evaluation.
A variety of neoplasms with rhabdoid differentiation have been reported in many sites. The authors describe a case of gastrointestinal stromal tumor (GIST) of the stomach that exhibited prominent rhabdoid features. Immunohistochemically, the tumor cells displayed positive staining for vimentin, c-kit, CD34, and alpha smooth muscle actin. Ultrastructural examination of the rhabdoid tumor cells revealed paranuclear whorls of intermediate filaments, which were immunoreactive for vimentin by both light microscopic immunohistochemical and protein A gold immunoelectron microscopic techniques. On H&E light microscopic examination alone, such a tumor could be mistaken for a variety of epithelial, mesenchymal, or other neoplasms that may show rhabdoid features. One report of GIST with a rhabdoid histologic phenotype has been described. This is the second known report of such a case with immunophenotypic and ultrastructural evaluation, and the first case with immunoelectron microscopic examination.
University of Vermont College of Medicine, Fletcher Allen Health Care, Department of Pathology, Burlington, Vermont 05401, USA. jeffrey.richmond@vtmednet.org
Jeffrey A
JA
Richmond
Sharon L
SL
Mount
Janet E
JE
Schwarz
D000199:Actins / Q000032:analysis; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D017809:Fatal Outcome; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000648:ultrastructure; D008297:Male; D046529:Microscopy, Electron, Transmission; D010641:Phenotype; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis
D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D014746:Vimentin; D019009:Proto-Oncogene Proteins c-kit