Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome.
We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17alpha, and did not observe an important modulatory effect of this variant on circulating DHEAS. It does not appear that this common variant of CYP17, a T to C substitution in the 5' promoter region, plays a significant role in the adrenal androgen excess of PCOS.
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Melissa
M
Kahsar-Miller
Larry R
LR
Boots
Alfred
A
Bartolucci
Ricardo
R
Azziz
D000293:Adolescent; D000311:Adrenal Glands / Q000378:metabolism; D000328:Adult; D000483:Alleles; D000728:Androgens / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000235:genetics; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D015144:Southeastern United States; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics* / Q000378:metabolism; D013739:Testosterone / Q000097:blood
D000728:Androgens; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate; D004247:DNA; D013254:Steroid 17-alpha-Hydroxylase