[Therapeutical effects of esculentoside A on rats with MsPGN induced by anti-Thy1.1 antibody].
OBJECTIVE
To observe the therapeutical effects of esculentoside A (EsA) on rats with mesangial proliferative glomerulonephritis (MsPGN) induced by anti-Thy1.1 antibody and make a comparison of the effects between EsA and dexamethasone (DXM).


METHODS
Wistar rats with MsPGN induced by anti-Thy1.1 serum (ATS) were randomly divided into 3 groups: EsA group, DXM group, and model group. Moreover, a normal group was used for comparison. The BUN, SCr, urinary protein and renal pathological changes were examined after 7 d treatment with EsA and DXM.


RESULTS
The urinary protein, cell count and mesangium area of glomerulus were significantly higher in all modeled groups than in normal group (P<0.001-0.05), and they were significantly lower in the treated groups than in untreated group (P<0.001-0.01).


CONCLUSIONS
The results suggest that EsA is effective for reducing the urinary protein excretion and inhibiting the proliferation process of glomerular mesangium and matrix in rats with MsPGN.
Zhang
Ke-fei
KF
Department of Nephrology, The First Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China.
Zhang
Liang
L
Wu
Xiong-fei
XF
Zhang
Xiang-gui
XG
Yu
Hong
H
Yi
Yang-hua
YH
Zhao
Shi-qi
SQ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D000906:Antibodies; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005920:Glomerular Mesangium / Q000378:metabolism; D015432:Glomerulonephritis, Membranoproliferative / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use*; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification / Q000627:therapeutic use*; D018800:Thy-1 Antigens / Q000276:immunology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000906:Antibodies; D004365:Drugs, Chinese Herbal; D012503:Saponins; D018800:Thy-1 Antigens; C076297:esculentoside A; D009828:Oleanolic Acid