Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity.
Modular polyketide synthases biosynthesise natural products through successive Claisen-type condensations, where one module is responsible for one round of chain extension. This review describes recent findings where this rule of co-linearity is broken, either by one module being bypassed (skipping) or through one module being used for multiple chain extension events (stuttering).
Moss
Steven J
SJ
Biotica Technology Ltd., Chesterford Research Park, Little Chesterford, Essex, UK CB10 1XL. steven.moss@biotica.co.uk
Martin
Christine J
CJ
Wilkinson
Barrie
B
D005075:Biological Evolution; D018942:Macrolides / Q000378:metabolism*; D008958:Models, Molecular; D048630:Polyketide Synthases / Q000737:chemistry / Q000145:classification / Q000235:genetics
D018942:Macrolides; D048630:Polyketide Synthases