Influence of felbamate on selected central effects of ethanol in experimental animals.
Both felbamate and ethanol demonstrate complex action on central nervous system (CNS). There are several data indicating that ethanol influences pharmacokinetics of new generation of antiepileptic drugs. Investigation of CNS interaction of felbamate and ethanol may bring up some suggestions as for adverse reactions of concomitance of these substances and consequences of such reactions are concerned. The influence of felbamate on the action of ethanol in a rota-rod test (1.5 g/kg), the duration of ethanol sleeping time (4 g/kg) as well as on spontaneous locomotor activity (2 g/kg) and ethanol-induced hypothermia (2.5 g/kg) was investigated. Felbamate was administered at a single dose (200 mg/kg i.p.) or as daily injections dose (50 mg/kg for 10 days). At a single dose, felbamate prolonged ethanol-sleeping time, increased ethanol-induced disturbances of motor coordination and ethanol-induced hypothermia as well as prevented increased locomotor activity observed after ethanol intake. Felbamate administered for 10 days reduced ethanol sleeping time, did not effect ethanol on locomotor activity of mice, but augmented ethanol-induced changes in motor coordination and ethanol hypothermia. These interactions may be of pharmacodynamic character, but pharmacokinetic nature cannot be excluded, felbamate and ethanol are substrates for the cytochrome CYP2E1.
Pietrzak
Bogusława
B
Department of Pharmacodynamics, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland. bpietrzak@pharm.am.lodz.pl
Czarnecka
Elzbieta
E
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D000078328:Felbamate; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D000431:Ethanol; D000078328:Felbamate