Sudden infant death syndrome due to parainfluenza virus 2 associated with hemophagocytic syndrome.
We report a child with Sudden Infant Death Syndrome (SIDS), aged 16 months. The histological findings of tonsils, spleen, and bone marrow revealed many hemophagocytic cells. Parainfluenza virus type 2 (PIV2) was cultured in the nasopharynx and detected by reverse-transcription (RT)-PCR in liver tissue and bone marrow. His laboratory data of elevated level of ferritin and IL-6 suggested hemophagocytic syndrome (HPS). It is suspected that PIV2 infection in infants is a risk factor for SIDS.
Kashiwagi
Yasuyo
Y
Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. hoyohoyo@tokyo-med.ac.jp
Kawashima
Hisashi
H
Kanetaka
Yuki
Y
Ioi
Hiroaki
H
Takekuma
Kouji
K
Hoshika
Akinori
A
Matsubayashi
Jun
J
Mukai
Kiyoshi
K
D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D010223:Parainfluenza Virus 2, Human / Q000302:isolation & purification*; D019351:Rubulavirus Infections / Q000150:complications* / Q000821:virology; D013398:Sudden Infant Death / Q000209:etiology*