Adverse reactions to voriconazole.
Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable--more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.
Boyd
Aileen E
AE
Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, United Kingdom.
Modi
Simon
S
Howard
Susan J
SJ
Moore
Caroline B
CB
Keevil
Brian G
BG
Denning
David W
DW
D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D014230:Triazoles / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole