Synthesis and fungicidal activity of ethaboxam against Oomycetes.
This study describes the chemical synthesis and intrinsic fungicidal activity of ethaboxam [(RS)-N-(alpha-cyano-2-thenyl)-4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide], a new Oomycetes fungicide. In in vitro tests, ethaboxam showed inhibitory activity against isolates of Phytophthora and some Pythium spp, with MIC values ranging from 0.1 to 0.5 mg litre(-1) for nine isolates of Phytophthora infestans (Montagne) de Bary and from 1.0 to 5.0 mg litre(-1) for eight isolates of Phytophthora capsici Leonian. In tests to determine time and concentration for complete inactivation of each pathogen (five isolates of P infestans and five isolates of P capsici), ethaboxam inactivated all isolates of P infestans within 48h at 10 mg litre(-1) and those of P capsici within 96 h at 10 mg litre(-1). Ethaboxam effectively suppressed development of tomato late blight caused by P infestans and pepper Phytophthora blight caused by P capsici in the studies conducted to determine its preventive, curative, persistent and systemic activity. These results show that ethaboxam has desirable fungicidal characteristics as an Oomycetes fungicide.
LG Life Sciences Ltd, R&D Park, 104-1, Moonjidong, Yuseonggu, Daejeon 305-380, Korea. dalskim@lgls.co.kr
Dal-Soo
DS
Kim
Sam-Jae
SJ
Chun
Jae-Jin
JJ
Jeon
Sang-Who
SW
Lee
Goon-Ho
GH
Joe
D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D009868:Oomycetes / Q000187:drug effects* / Q000254:growth & development; D010838:Phytophthora / Q000187:drug effects / Q000254:growth & development; D010935:Plant Diseases / Q000382:microbiology*; D011775:Pythium / Q000187:drug effects / Q000254:growth & development; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*
D005659:Fungicides, Industrial; D013844:Thiazoles; D013876:Thiophenes; C492076:ethaboxam