A ring-rearrangement metathesis approach toward the synthesis of cyclopenta- and cyclohexa[c]indene systems.
[reaction: see text] A highly efficient synthesis of angularly fused tricyclic enones, cyclopenta- and cyclohexa[c]indene skeletons, has been achieved by the tether-directed ring-rearrangement metathesis sequence starting with readily accessible norbornene derivatives bearing allyl and homoallyl groups at the bridging carbon.
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Jeremy
J
Holtsclaw
Masato
M
Koreeda