Brugada electrocardiographic pattern elicited by inadvertent flecainide overdose.
In a 70-year-old man, without clinical suggestion of the hereditary form of the Brugada syndrome, severe flecainide overdose resulted in profound widening of the QRS complex and the development of ST-T abnormalities typical of the Brugada sign. Serial ECGs recorded over a 5-day period revealed a parallel pattern of dynamic intraventricular conduction defect and ST-segment elevation. Resolution of ST-segment elevation lagged behind resolution of the QRS widening by 16-20 hours. Despite the marked Brugada abnormality no arrhythmia occurred and the patient recovered without complications.
Department of Internal Medicine, P.A. Carolinas Medical Center, Charlotte, North Carolina 28232, USA.
Christopher J
CJ
Hudson
Tanya E
TE
Whitner
Michael J
MJ
Rinaldi
Laszlo
L
Littmann
D000368:Aged; D002037:Bundle-Branch Block / Q000139:chemically induced* / Q000503:physiopathology; D062787:Drug Overdose; D004562:Electrocardiography; D005424:Flecainide / Q000506:poisoning*; D006801:Humans; D008297:Male
D005424:Flecainide