Fermentative production of chemicals that can be used for polymer synthesis.
The fermentative production of chemicals that can be used as monomers for the synthesis of polymers has become an important topic in biotechnology research because of the limited nature of petroleum and environmental issues. In particular, the fermentative production of metabolites such as dicarboxylic acids, amino acids, and diols, which are suitable as building blocks for subsequent polymerization, has attracted much attention. Various wild-type and metabolically engineered microorganisms have been developed for the efficient production of these chemicals from renewable resources. In addition, the development of fermentation strategies to achieve the highest possible productivities has been another focus of research, considering that these monomers should be produced at costs low enough to compete with petroleum-derived ones. In this paper, the metabolic pathways leading to the synthesis of such important monomers including succinic acid, lactic acid, fumaric acid, propan-1,2-diol, and propan-1,3-diol are reviewed. In addition, the metabolic engineering and fermentation strategies for their production are reviewed.
Department of Chemical & Biomolecular Engineering and BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea. leesy@kaist.ac.kr
Sang Y
SY
Lee
Soon H
SH
Hong
Seung H
SH
Lee
Si J
SJ
Park
D001709:Biotechnology / Q000379:methods*; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism*; D003998:Dicarboxylic Acids / Q000378:metabolism; D005285:Fermentation; D011108:Polymers / Q000138:chemical synthesis*; D019946:Propylene Glycol / Q000378:metabolism; D011409:Propylene Glycols / Q000737:chemistry / Q000378:metabolism*
D002264:Carboxylic Acids; D003998:Dicarboxylic Acids; D011108:Polymers; D011409:Propylene Glycols; D019946:Propylene Glycol