Synthesis and biological activity of new derivatives of 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid.
New 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid derivatives (8-14) were synthesized by condensation of N(3)-substituted amidrazones (1-7) with maleic anhydride. Molecular structure of obtained compounds was confirmed by an elemental analysis, IR and (1)H NMR spectra, and the X-ray crystallography for compound 11. The influence of the compound 9 on the central nervous system (CNS) of mice in some behavioural test was examined. The investigated compound showed anticonvulsive activity and potent antinociceptive action.
Department of Organic Chemistry, Medical University, Jagiellońska 13, 85-067 Bydgoszcz, Poland. modzel@panaceum.am.lublin.pl
Boźena
B
Modzelewska-Banachiewicz
Jacek
J
Banachiewicz
Anna
A
Chodkowska
Ewa
E
Jagiełło-Wójtowicz
Liliana
L
Mazur
D000475:Alkenes / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000475:Alkenes; D000927:Anticonvulsants; D014230:Triazoles; C013658:propylene