Antigen assay with the potential to aid in diagnosis of blastomycosis.
We report results of an immunoassay for Blastomyces dermatitidis antigenuria. Sensitivity was 92.9%, and specificity was 79.3%. Cross-reactions occurred in 96.3% of patients with histoplasmosis, 100% of patients with paracoccidioidomycosis, 70% of patients with penicilliosis marneffei, 2.9% of patients with cryptococcosis, and 1.1% of patients with aspergillosis. Reproducibility was 96.3%. These findings support a potential role for antigen testing in blastomycosis.
Durkin
Michelle
M
MiraVista Diagnostics/MiraBella Technologies, Indianapolis, Indiana 46241, USA. mdurkin@miravistalabs.com
Witt
John
J
Lemonte
Ann
A
Wheat
Blair
B
Connolly
Patricia
P
D000946:Antigens, Fungal / Q000652:urine*; D001758:Blastomyces / Q000302:isolation & purification*; D001759:Blastomycosis / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D007118:Immunoassay / Q000379:methods; D012680:Sensitivity and Specificity
D000946:Antigens, Fungal