Synthesis of AB diblock copolymers by atom-transfer radical polymerization (ATRP) and living polymerization of alpha-amino acid-N-carboxyanhydrides.
The synthesis of poly(methyl acrylate)-block-poly(gamma-benzyl-L-glutamate) (PMA-b-PBLG) diblock copolymers, using atom-transfer radical polymerization (ATRP) of methyl acrylate and living polymerization of gamma-benzyl-L-glutamate-N-carboxyanhydride (Glu-NCA) is described. Amido-amidate nickelacycle end groups were incorporated onto amino-terminated poly(methyl acrylates), and the resulting complexes were successfully used as macroinitiators for the growth of polypeptide segments. This method allows the controlled preparation of polypeptide-block-poly(methyl acrylate) diblock architectures with control over polypeptide chain length and without the formation of homopolypeptide contaminants.
Materials Research Laboratory, Chemistry Department, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
Krystyna R
KR
Brzezinska
Timothy J
TJ
Deming
D000596:Amino Acids / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis*; D011109:Polymethacrylic Acids / Q000737:chemistry*
D000596:Amino Acids; D000812:Anhydrides; D011108:Polymers; D011109:Polymethacrylic Acids; C003172:poly-gamma-benzyl-L-glutamate; C030613:polymethacrylic acid; D011099:Polyglutamic Acid