Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential.
A series of C2-exo-fluorounsaturated pyrrolobenzodiazepines (PBDs) have been synthesized. These C2-exo-fluorounsaturated PBD dimers have exhibited remarkable DNA-binding affinity.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@ins.iictnet.com
Reddy
P S M M
PS
Reddy
D Rajasekhar
DR
Laxman
E
E
Murthy
Y L N
YL
D001569:Benzodiazepines / Q000138:chemical synthesis / Q000494:pharmacology; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites / Q000187:drug effects; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D017611:Fluorine Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008968:Molecular Conformation; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
C423343:1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione); D001570:Benzodiazepinones; D017611:Fluorine Compounds; D011758:Pyrroles; D001569:Benzodiazepines; D004247:DNA