Possible reduction in posttraumatic stress disorder symptoms with oxcarbazepine in a patient with bipolar disorder.
OBJECTIVE
To report the effect of oxcarbazepine in a patient with bipolar illness and posttraumatic stress disorder (PTSD).


METHODS
A 38-year-old white woman with PTSD and bipolar disorder who had partially responded to carbamazepine was treated with oxcarbazepine. Within a month of initiation of treatment with oxcarbazepine, she reported progressive improvement in her PTSD symptoms. As oxcarbazepine monotherapy with 750 mg twice daily continued, she reported significant reduction of her PTSD symptoms and stabilization of her mood. She tolerated oxcarbazepine without adverse effects.


CONCLUSIONS
PTSD symptoms tend to wax and wane. Spontaneous remission also occurs in some patients with PTSD. There are a few reports indicating that carbamazepine alleviates PTSD symptoms. Since oxcarbazepine is an analog of carbamazepine, it is theorized that oxcarbazepine also has efficacy in significantly reducing PTSD symptoms.


CONCLUSIONS
There are case reports and uncontrolled studies suggesting that antiepileptic drugs (AEDs) alleviate PTSD symptoms. Oxcarbazepine may also benefit patients with PTSD. However, controlled studies are needed to investigate the use of AEDs in patients with PTSD and bipolar disorder.
Department of Neuropsychiatry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA. parviz.malekahmadi@ttuhsc.edu
Parviz
P
Malek-Ahmadi
Allan T
AT
Hanretta
D000328:Adult; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy*; D002220:Carbamazepine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D000078330:Oxcarbazepine; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000188:drug therapy*
D002220:Carbamazepine; D000078330:Oxcarbazepine