No effect of bovine interferon-tau for control of calf diarrhea and immunomodulation in calves.
Newborn calves received a low dose of bovine interferon-tau (boIFN-tau) orally for 4 weeks and calves that had developed diarrhea received a low dose of boIFN-tau orally for 5 days. No effects of boIFN-tau were seen in the duration of the diarrhea, or in daily weight gain. Calves received a high dose of boIFN-tau subcutaneously 3 times and they were then stimulated with bovine herpesvirus type 1 vaccine. No adverse effects were observed after the administration of boIFN-tau and lymphocyte subsets from calves did not change after the stimulation. Our results suggest that boIFN-tau does not seem protecting for preventing calves from diarrhea, recovering the health of calves with diarrhea or immunomodulation, although the treatment itself is not toxic.
Kohara
Junko
J
Hokkaido Animal Research Center, Shintoku, hokkaido, Japan.
Yayota
Chizuru
C
Yokomizo
Yuichi
Y
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000188:drug therapy*; D003967:Diarrhea / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D007370:Interferon Type I / Q000276:immunology / Q000627:therapeutic use*; D018655:Lymphocyte Count / Q000662:veterinary; D011257:Pregnancy Proteins / Q000276:immunology / Q000627:therapeutic use*; D013997:Time Factors
D007370:Interferon Type I; D011257:Pregnancy Proteins; C020947:interferon tau