[Induction of an immune response to mycobacterial antigens by means of dendritic cells].
The study evaluated whether a vaccine can be designed by using dendritic cells loaded by mycobacterial antigens. A method for preparing murine dendritic cells from the bone-marrow precursors was modified. The dendritic cells were characterized by the expression of surface molecules by flow cytofluorometry. The study has shown that T lymphocytes can be primed in vivo by administering the dendritic cells expressing the protective Mycobacterium tuberculosis antigens H37Rv.
S N
SN
Petrovskaia
E I
EI
Rubakova
A S
AS
Apt
T K
TK
Kondrat'eva
D000942:Antigens, Bacterial / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology*; D003712:Dendrites / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D005822:Genetic Vectors; D006801:Humans; D008213:Lymphocyte Activation; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011994:Recombinant Proteins
D000942:Antigens, Bacterial; D015703:Antigens, CD; D018984:Epitopes, T-Lymphocyte; D011994:Recombinant Proteins