A combined linkage-physical map of the human genome.
We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N=14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.
Kong
X
X
Department of Genetics, Rutgers University, Piscataway, NJ 08840, USA.
Murphy
K
K
Raj
T
T
He
C
C
White
P S
PS
Matise
T C
TC
D002874:Chromosome Mapping; D030541:Databases, Genetic; D005819:Genetic Markers / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D020161:Physical Chromosome Mapping; D011110:Polymorphism, Genetic
D005819:Genetic Markers