Interleukin-8, neutropenia, and graft failure in human stem cell transplantation.
We studied the role of interleukin (IL)-8 during engraftment after hematopoietic stem cell transplantation. In 40 consecutive patients undergoing either allogeneic marrow (n=32) or autologous peripheral blood stem cell transplantation (n=8), IL-8 plasma levels were serially determined. Median IL-8 concentrations peaked during the neutropenic phase and, subsequently, subsided to pretransplant levels in patients achieving engraftment. In all patients, we observed an inverse correlation of IL-8 with leukocytes (P<0.0001) and a direct correlation of IL-8 with the extent of neutropenia (P<0.0001). Four patients who developed graft failure showed sustained median IL-8 concentrations of >300 pg/mL together with persistent neutropenia. This marked elevation of IL-8 was statistically significant as early as day 11 after transplantation, at a time when no other evidence alluded to imminent graft failure. Our data suggest that IL-8 may play an important role during engraftment after hematopoietic stem cell transplantation.
Department of Hematology and Oncology, University of Freiburg Medical Center, Hugstetterstrasse, Freiburg, Germany.
Michael
M
Schwabe
Anne-Mone
AM
Hartert
Hartmut
H
Bertz
Jürgen
J
Finke
D006801:Humans; D016209:Interleukin-8 / Q000097:blood / Q000502:physiology*; D009503:Neutropenia / Q000097:blood*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous
D016209:Interleukin-8