[Experimental studies of lycopene in inhibiting tumor growth in S180-bearing mice].
OBJECTIVE
To observe the effect of lycopene (LP) on tumor in mice.


METHODS
S180-bearing mice were used as animal model. The mice were given LP by oral. The effects of LP on tumor weight, immune function and antioxidative enzyme were measured respectively.


RESULTS
LP group could promote spleen lymphocyte proliferation, NK activity and increase activity of SOD, GSH-Px and decreased the concentrations of MDA significantly compared with model group (P < 0.05).


CONCLUSIONS
LP could inhibit the growth of S180 tumor. The antitumor effect may be related to its immune function and antioxidative effect.
Public Health School of Harbin Medical University, Harbin 150001, China.
Hongzhi
H
Pan
Xiumei
X
Jiang
Likui
L
Wan
Lixin
L
Na
Jun
J
Wang
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D000077276:Lycopene; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D002338:Carotenoids; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000077276:Lycopene