Neuronal microcircuits: frequency-dependent flow of inhibition.
New work suggests that feedback inhibition of neurons in the hippocampus is mediated by two distinct microcircuits. Interneurons targeting a neuron's soma are triggered by onset of activity, while those targeting distal dendrites are recruited by sustained activity. These circuits may thus convey information about the timing and rate of activity, respectively.
Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK.
Wolfgang
W
Mittmann
Paul
P
Chadderton
Michael
M
Häusser
D000818:Animals; D003712:Dendrites / Q000502:physiology; D025461:Feedback, Physiological / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007395:Interneurons / Q000502:physiology*; D008959:Models, Neurological; D017966:Pyramidal Cells / Q000502:physiology; D011999:Recruitment, Neurophysiological / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology