Multiple myofibromas and an epidermal verrucous nevus in a child with neurofibromatosis type 1.
Neurofibromatosis type 1 (NF1) is a common neurocutaneous autosomal dominant genetic disorder affecting primarily tissues derived from the embryonic neural crest. Two hallmark features of NF1 are the wide range of potentially affected tissues and the enormous phenotypic variability of disease traits even among patients from the same family. We present a boy fulfilling the diagnostic criteria for NF1 with two unusual lesions: infantile myofibromatosis and a verrucous epidermal nevus. To our knowledge this association has never been described before.
Department of Dermatology, University Hospital Ghent, Ghent, Belgium.
Sofie
S
De Schepper
Sandra
S
Janssens
Ludwine
L
Messiaen
Caroline
C
Van den Broecke
Jean-Marie
JM
Naeyaert
D002675:Child, Preschool; D006801:Humans; D008297:Male; D018224:Myofibromatosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D009506:Nevus / Q000150:complications* / Q000473:pathology; D010375:Pedigree; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery