Contrast dependence of suppressive influences in cortical area MT of alert macaque.
Visual neurons are often characterized in terms of their tuning for various stimulus properties, such as shape, color, and velocity. Generally, these tuning curves are further modulated by the overall intensity of the stimulus, such that increasing the contrast increases the firing rate, up to some maximum. In this paper, we describe the tuning of neurons in the middle temporal area (MT or V5) of macaque visual cortex for moving stimuli of varying contrast. We find that, for some MT neurons, tuning curves for stimulus direction, speed, and size are shaped in part by suppressive influences that are present at high stimulus contrast but weak or nonexistent at low contrast. For most neurons, the suppression is direction-specific and strongest for large, slow-moving stimuli. The surprising consequence of this phenomenon is that some MT neurons actually fire more vigorously to a large low-contrast stimulus than to one of high contrast. These results are consistent with recent perceptual observations, as well as with information-theoretic models, which hypothesize that the visual system seeks to reduce redundancy at high contrast while maintaining sensitivity at low contrast.
Pack
Christopher C
CC
Deptartment of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, MA 02115, USA. cpack@hms.harvard.edu
Hunter
J Nicholas
JN
Born
Richard T
RT
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001143:Arousal / Q000502:physiology*; D015350:Contrast Sensitivity / Q000502:physiology; D008251:Macaca; D015233:Models, Statistical; D009039:Motion Perception / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D013028:Space Perception / Q000502:physiology; D013702:Temporal Lobe / Q000166:cytology*; D014795:Visual Pathways / Q000502:physiology*