[In vitro alternatives to Draize eye irritation test].
For reasons of animal welfare and better science, a series of in vitro methods, including assays based isolated eye or cornea, Chorioallantoic membrane, cultured tissue or cell, had been established and evaluated to replace the Draize eye irritation test. This paper provides a brief review of the recent progress in the in vitro alternatives to Draize eye irritation test, and the principles of scientific validation of these alternatives were also discussed.
Zhou
Jianchang
J
Institute of Toxicology, Guangdong Center for Disease Control and Prevention, Guangzhou 510300, China.
Yang
Mingjie
M
Yang
Xingfen
X
He
Xiwen
X
D000826:Animal Testing Alternatives / Q000379:methods*; D000818:Animals; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000187:drug effects; D003315:Cornea / Q000187:drug effects; D005123:Eye / Q000187:drug effects*; D007509:Irritants / Q000633:toxicity*; D011817:Rabbits
D007509:Irritants