Haplotypes of the beta2-adrenergic receptor gene are associated with essential hypertension in a Singaporean Chinese population.
OBJECTIVE
To investigate the relation between the gene encoding the beta2-adrenergic receptor (B2AR) and essential hypertension in a Singaporean Chinese cohort.


METHODS
Three single nucleotide polymorphisms (SNPs) were genotyped in 190 cases and 323 controls, and eight haplotypes were determined and tested for association using the likelihood test statistic.


RESULTS
We observed a significant difference in haplotype frequency distributions between the cases and the controls (P <0.00001). A logistic regression model fitted to the data supported this finding.


CONCLUSIONS
The results suggest that variants at the B2AR locus may play a role in the pathophysiology of hypertension in this population.
Lee
Yee-Wei
YW
Division of Clinical Pharmacology, Department of Medicine, National University of Singapore.
Oh
Vernon M S
VM
Garcia
Edwin
E
Taylor
Elizabeth A
EA
Wu
Huimin
H
Yap
Eric Ph
EP
Kazeem
Gbenga R
GR
Caulfield
Mark J
MJ
Munroe
Patricia B
PB
D000328:Adult; D044466:Asian People / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012044:Regression Analysis; D012846:Singapore
D018343:Receptors, Adrenergic, beta-2