Effect of obesity and thoracic epidural analgesia on perioperative spirometry.
BACKGROUND
Lung volumes in obese patients are reduced significantly in the postoperative period. As the effect of different analgesic regimes on perioperative spirometric tests in obese patients has not yet been studied, we investigated the effect of thoracic epidural analgesia and conventional opioid-based analgesia on perioperative lung volumes measured by spirometry.


METHODS
Eighty-four patients having midline laparotomy for gynaecological procedures successfully completed the study. Premedication, anaesthesia and analgesia were standardized. The patients were given a free choice between epidural analgesia (EDA) (n=42) or opioids (n=42) for postoperative analgesia. We performed spirometry to measure vital capacity (VC), forced vital capacity, peak expiratory flow, mid-expiratory flow and forced expiratory volume in 1 s at preoperative assessment, 30-60 min after premedication and 20 min, 1 h, 3 h and 6 h after extubation.


RESULTS
Baseline values were all within the normal range. All perioperative spirometric values decreased significantly with increasing body mass index (BMI). The greatest reduction in VC occurred directly after extubation, but was less in the EDA group than in the opioid group: mean of -23(sd 8)% versus -30(12)% (P<0.001). In obese patients (BMI>30) the difference in VC was significantly more pronounced than in patients of normal weight (BMI<25): -45(10)% versus -33(4)% (P<0.001). Recovery of spirometric values was significantly quicker in patients receiving EDA, particularly in obese patients.


CONCLUSIONS
We conclude that EDA should be considered in obese patients undergoing midline laparotomy to improve postoperative spirometry.
Department of Anaesthesia, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland. bvonungern@uhbs.ch
B S
BS
von Ungern-Sternberg
A
A
Regli
A
A
Reber
M C
MC
Schneider
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015360:Analgesia, Epidural; D000701:Analgesics, Opioid / Q000494:pharmacology; D000768:Anesthesia, General / Q000379:methods; D015992:Body Mass Index; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D008176:Lung Volume Measurements; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D010149:Postoperative Pain / Q000628:therapy*; D011184:Postoperative Period; D011446:Prospective Studies; D012143:Respiratory Physiological Phenomena / Q000187:drug effects*; D012307:Risk Factors; D013147:Spirometry
D000701:Analgesics, Opioid