[Signal transduction pathways and transcription factors involved in luteinizing hormone beta subunit gene expression].
The pulsatile pattern of the hypothalamic hormone gonadotropin-releasing hormone (GnRH) plays a critical role in reproductive function by regulating the biosynthesis and secretion of the pituitary gonadotropins. Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) are heterodimeric glycoproteins composed of a common peptide, the glycoprotein hormone subuint alpha, and either a specific FSHbeta or LHbeta polypeptide. GnRH regulates LHbeta gene expression through GnRH receptor activation of the protein kinase C (PKC) and calcium signaling cascades. Recently, many transcription factors, such as early growth response-1 (Egr-1), steroidogenic factor-1 (SF-1), Ptx1 and Sp1, have been recognized to be involved in expression of the LHbeta gene through binding to the promoter region of LHbeta gene.
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095.
Lian
L
Li
Gen-Lin
GL
Wang
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005786:Gene Expression Regulation; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000235:genetics* / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D011966:Receptors, LHRH / Q000235:genetics; D015398:Signal Transduction; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*
C515057:NR5A1 protein, human; D011966:Receptors, LHRH; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D011493:Protein Kinase C; D002118:Calcium