Requirement of c-myb in T cell development and in mature T cell function.
Previous reports have suggested that the protooncogene c-myb participates in T cell development in the thymus and mature T cell proliferation. We have generated two T cell-specific c-myb knockout mouse models, myb/LckCre and myb/CD4Cre. We have demonstrated that c-myb is required for the development of thymocytes at the DN3 stage, for survival and proliferation of double-positive thymocytes, for differentiation of single-positive CD4 and CD8 T cells, and for the proliferative responses of mature T cells. In addition, our data show that c-myb is directly involved in the formation of double-positive CD4+CD8+CD25+, CD4+CD25+, and CD8+CD25+ T cells, developmental processes that may imply a role for c-myb in autoimmune dysfunction.
Lieu
Yen K
YK
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Kumar
Atul
A
Pajerowski
Anthony G
AG
Rogers
Thomas J
TJ
Reddy
E Premkumar
EP
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D002455:Cell Division; D002470:Cell Survival; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D020570:Genes, myb / Q000235:genetics*; D005838:Genotype; D051379:Mice; D018345:Mice, Knockout; D020598:Proto-Oncogene Proteins c-myb / Q000172:deficiency / Q000235:genetics*; D015183:Restriction Mapping; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology*; D013950:Thymus Gland / Q000276:immunology
D020598:Proto-Oncogene Proteins c-myb