Pharmacokinetics, stability, and retrospective analysis of use of an oral gel formulation of the bovine injectable enrofloxacin in horses.
In many cases of equine infectious disease, long-term administration of antimicrobial drugs is required. Oral agents are preferred because of the relative ease of administration compared with other routes. Enrofloxacin has been shown to be effective against a variety of equine pathogens, but oral administration of this drug has proved difficult in horses. An oral gel formulation made from the injectable cattle product produces blood levels sufficient to resolve infections caused by a variety of common equine pathogens.
Epstein
Kira
K
Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, PA, USA.
Cohen
Noah
N
Boothe
Dawn
D
Nieuwoudt
Cornelia
C
Chandler
Jeff
J
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D019540:Area Under Curve; D001424:Bacterial Infections / Q000188:drug therapy / Q000662:veterinary*; D001682:Biological Availability; D018592:Cross-Over Studies; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005782:Gels; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D015363:Quinolones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012189:Retrospective Studies; D013696:Temperature; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D024841:Fluoroquinolones; D005782:Gels; D015363:Quinolones; D000077422:Enrofloxacin