The potential calcification of octacalcium phosphate on intraocular lens surfaces.
Recently, calcification was observed on implanted intraocular lens (IOL) surfaces when viscoelastic substances were applied during surgery. To elucidate the mechanisms of mineral formation, the crystallization of calcium phosphates on IOL surfaces was studied in vitro with nanomolar sensitivity using a constant composition method. Three different commercial viscoelastic materials (Viscoat, OcuCoat, and Amvisc Plus) were investigated and it was found that some IOLs treated with Viscoat or Amvisc Plus induced the nucleation and growth of octacalcium phosphate crystallites under biological conditions. After treatments, the IOL surfaces became more hydrophilic probably because of the high viscoelastic phosphate and carboxylate contents. In contrast to Viscoat, the use of OcuCoat during surgery resulted in virtually no octacalcium phosphate nucleations. Calcification studies of IOL surfaces treated with fatty acids, which are present in human aqueous humor, suggest that hydrophobic cyclic silicones adsorbed on the IOL surfaces interact strongly with hydrophobic hydrocarbon chains of the fatty acids, creating a layer of amphiphiles oriented with functional carboxylate groups exposed to the aqueous solution and serving as active calcification sites.
Guan
Xiangying
X
Department of Chemistry, 756 Natural Sciences Complex, The State University of New York at Buffalo, Buffalo, New York 14260, USA.
Tang
Ruikang
R
Nancollas
George H
GH
D002114:Calcinosis; D002130:Calcium Phosphates / Q000737:chemistry*; D003460:Crystallization; D003500:Cyclization; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology; D007910:Lenses, Intraocular; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D012825:Silicon / Q000737:chemistry / Q000494:pharmacology
D002130:Calcium Phosphates; D005227:Fatty Acids; C022045:octacalcium phosphate; D012825:Silicon