Quinolone resistance is associated with increased risk of invasive illness or death during infection with Salmonella serotype Typhimurium.
In a registry-based cohort study, we determined the risk of invasive illness or death associated with infection with quinolone-resistant Salmonella serotype Typhimurium. We linked data from the Danish surveillance registry of enteric pathogens with data from the Danish civil registration system and 2 national health registries. Of 1323 patients infected with Salmonella Typhimurium, 46 (3.5%) were hospitalized due an invasive illness within 90 days of infection, and 16 (1.2%) died within 90 days of infection. After adjustment for age, sex, and comorbidity, infection with quinolone-resistant Salmonella Typhimurium was associated with a 3.15-fold (95% confidence interval, 1.39-7.10-fold) higher risk of invasive illness or death within 90 days of infection, compared with that observed for infection with pansusceptible strains.
Helms
Morten
M
Department of Epidemiology Research, Danish Epidemiology Science Center, Copenhagen, Denmark.
Simonsen
Jacob
J
Molbak
Kare
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015331:Cohort Studies; D003718:Denmark; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D015363:Quinolones / Q000494:pharmacology*; D018570:Risk Assessment; D012480:Salmonella Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence
D000900:Anti-Bacterial Agents; D015363:Quinolones