Successful treatment of disseminated nonmeningeal coccidioidomycosis with voriconazole.
A 31-year-old Jamaican man with disseminated nonmeningeal coccidioidomycosis that involved the spine, ribs, pelvis, liver, and spleen did not clinically respond to a prolonged course of both amphotericin B deoxycholate and liposomal amphotericin B therapy. After institution of voriconazole monotherapy, the patient had a favorable (albeit slow) radiological and clinical response without adjunctive surgical intervention.
Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Rajesh M
RM
Prabhu
Mark
M
Bonnell
Bradford L
BL
Currier
Robert
R
Orenstein
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003047:Coccidioidomycosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole