Elongation by RNA polymerase II: the short and long of it.
Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP II) have identified this stage as a dynamic and highly regulated step of the transcription cycle. Here, we discuss the many factors that regulate the elongation stage of transcription. Our discussion includes the classical elongation factors that modulate the activity of RNAP II, and the more recently identified factors that facilitate elongation on chromatin templates. Additionally, we discuss the factors that associate with RNAP II, but do not modulate its catalytic activity. Elongation is highlighted as a central process that coordinates multiple stages in mRNA biogenesis and maturation.
Howard Hughes Medical Institute, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
Robert J
RJ
Sims
Rimma
R
Belotserkovskaya
Danny
D
Reinberg
D000255:Adenosine Triphosphate / Q000378:metabolism; D002843:Chromatin / Q000502:physiology; D006657:Histones / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D010766:Phosphorylation; D012319:RNA Polymerase II / Q000378:metabolism / Q000502:physiology*; D012322:RNA Precursors / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*; D035602:Transcriptional Elongation Factors / Q000378:metabolism / Q000502:physiology
D002843:Chromatin; D006657:Histones; D018832:Molecular Chaperones; D012322:RNA Precursors; D012333:RNA, Messenger; D035602:Transcriptional Elongation Factors; D000255:Adenosine Triphosphate; D012319:RNA Polymerase II