Expanded nuclear roles for IkappaBs.
I kappa B (IkappaB) was initially identified as a factor that inhibits DNA binding and nuclear translocation of the transcription factor nuclear factor kappa B (NF-kappaB). Recently, however, IkappaB family members have demonstrated direct nuclear roles in regulating NF-kappaB-dependent transcription. Some IkappaB proteins, including IkappaBalpha and IkappaBbeta, can regulate transcription by modulating the concentration of active NF-kappaB complexes within the nucleus. Others, such as IkappaBzeta and Bcl-3, can directly activate transcription by forming transcriptional complexes at gene promoters. Thus, IkappaB proteins play important nuclear roles in regulating NF-kappaB-dependent transcription after stimulation with various extracellular signals.
Department of Pharmacology, University of Wisconsin-Madison Medical School, 301 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA.
Paul W
PW
Bates
Shigeki
S
Miyamoto
D000818:Animals; D006801:Humans; D020672:I-kappa B Proteins / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology*
D020672:I-kappa B Proteins; D009687:Nuclear Proteins