Interferon-gamma and granulocyte colony-stimulating factor in bronchoalveolar lavage fluid after oesophagectomy.
BACKGROUND
Activated polymorphonuclear leucocytes play a pivotal role in pulmonary complications after oesophagectomy. A lot of inflammatory mediators including interferon-gamma and granulocyte colony-stimulating factor are reported to modify the life span of polymorphonuclear leucocytes.


OBJECTIVE
In this study we investigated whether interferon-gamma and granulocyte colony-stimulating factor are associated with pulmonary complications after oesophagectomy.


METHODS
We measured interferon-gamma and granulocyte colony-stimulating factor concentrations in bronchoalveolar lavage fluid of 37 patients who had undergone oesophagectomy and examined the relationship between these mediators and pulmonary complications.


RESULTS
Pulmonary complications occurred in nine patients (24%, Pneum(+)). There was no significant difference in age, gender, preoperative comorbid conditions, tumour stage, operation method, operating time or blood loss between the Pneum(+) group and another 28 patients(Pneum(-)). Days until extubation were significantly increased in the Pneum(+) group than in the Pneum(-) group. Interferon-gamma (on postoperative day 2) and granulocyte colony-stimulating factor (on postoperative days 1-3) in bronchoalveolar lavage fluid were significantly increased in the Pneum(+) group than in the Pneum(-) group and granulocyte colony-stimulating factor was significantly correlated with days until extubation.


CONCLUSIONS
Our results indicate that bronchoalveolar lavage fluid granulocyte colony-stimulating factor is associated with respiratory conditions after oesophagectomy and assaying it can be useful for predicting pulmonary complications.
Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 3-39-22 Showamachi, Maebashi 371-8511, Japan. katukada@topaz.ocn.ne.jp
K
K
Tsukada
T
T
Miyazaki
H
H
Katoh
N
N
Masuda
H
H
Ojima
M
M
Fukuchi
R
R
Manda
Y
Y
Fukai
M
M
Nakajima
M
M
Sohda
H
H
Kuwano
D001992:Bronchoalveolar Lavage Fluid; D016629:Esophagectomy / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis*; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D008168:Lung / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality; D015996:Survival Rate
D016179:Granulocyte Colony-Stimulating Factor; D007371:Interferon-gamma