[The effect of various stage maturity of erythrocytes upon proliferatio rate of erythroid cells in "crown" of erythroblastic islands].
Joint cultivation of small amounts of young and mature erythrocytes with bone marrow erythroblastic islands during 24 hours in liquid culture system results in erythropoiesis stimulation due to increase of number of cells in the state of mitosis in island's "crown". Prolonged joint cultivation and/or joint cultivation with plenty of premature and mature erythrocytes leads to inhibition of the erythropoiesis in the state of mitosis in the island's "crown". The maximum of the inhibitory effect was shown by erythrocytes from polycythemia rats.
Iu M
IuM
Zakharov
S A
SA
Sheviakov
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D018920:Coculture Techniques; D004900:Erythroblasts / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D041905:Erythroid Cells / Q000166:cytology; D004920:Erythropoiesis / Q000502:physiology*; D008297:Male; D008938:Mitosis / Q000502:physiology; D051381:Rats