Complex cytogenetics in a case of probably work related MDS/AML.
In the majority of cases of overt acute myeloid leukemia (AML), there is no knowledge about a preleukemic phase of myelodysplastic syndrome (MDS). A few recent case-control studies suggest an association between MDS and several occupations. We report a unique case of MDS/AML related to the patient's work condition with numerous cytostatic agents. The karyotype revealed a spectrum of genetic rearrangements identified by conventional cytogenetics, fluorescence in situ hybridization (FISH) and spectral karyotyping (SKY). We suggest that amplification of chromosomal material may play a greater role in leukemogenesis than has been recognized previously.
Department of Hematology, Jagiellonian University Medical College, Kopernika 17, 31-501 Krakow, Poland. salaman@hemat.cm-uj.krakow.pl
Zoriana
Z
Salamanchuk
Małgorzata
M
Jakóbczyk
Wiesław
W
Nowak
Aleksander B
AB
Skotnicki
D000208:Acute Disease; D000477:Alkylating Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001856:Bone Marrow Examination; D020732:Cytogenetic Analysis; D004791:Enzyme Inhibitors / Q000009:adverse effects; D005260:Female; D020440:Gene Duplication; D015321:Gene Rearrangement; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000209:etiology / Q000235:genetics*; D016273:Occupational Exposure / Q000009:adverse effects*; D059005:Topoisomerase II Inhibitors
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors