Antioxidant activities of a new lignan and a neolignan from Saururus chinensis.
A new diarylbutane lignan, 2'-hydroxy dihydroguaiaretic acid (4), and a known 8-O-4'-type neolignan, machilin D (5), were isolated from the ethyl acetate extracts of the underground parts of Saururus chinensis. Compounds 4 and 5 exhibited low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substances (TBARS) assay (4: IC(50)=3.3 microM and 5: IC(50)=3.8 microM), the lag time of conjugated diene production, the relative electrophoretic mobility (REM) of ox-LDL, the apoB-100 fragmentation on copper-mediated LDL oxidation and the macrophage-mediated LDL oxidation, and radical DPPH scavenging activity.
Lee
Woo Song
WS
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Daejeon 305-333, Republic of Korea.
Baek
Young-Il
YI
Kim
Ju-Ryoung
JR
Cho
Kyung-Hyun
KH
Sok
Dai-Eun
DE
Jeong
Tae-Sook
TS
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors; D008264:Macrophages / Q000187:drug effects; D008968:Molecular Conformation; D032134:Saururaceae / Q000737:chemistry*; D013997:Time Factors
C497853:2'-hydroxy dihydroguaiaretic acid; D000975:Antioxidants; D017705:Lignans; D008077:Lipoproteins, LDL; C446120:machilin D