[Anti-inflammatory cytokines of cervical secretions and the blood serum in women with genital infections].
In cervical secretions of healthy non-pregnant women of the reproductive age high concentrations of ant-inflammatory cytokines, greatly exceeding those in blood serum, were detected. During pregnancy the level of TNF-alpha in cervical secretions dropped. The inflammation of the uterus neck was accompanied by a drop in the levels of IL-alpha and IL-1beta and a rise in the level of IL-8 in cervical secretions in pregnant and non-pregnant women. Similar changes in the cytokine profile occurred also in the blood serum, but they were less pronounced and could be observed only in non-pregnant women. The threat of the interruption of pregnancy, developing simultaneously with cervicitis, was accompanied not only by changes in the levels of cytokines in cervical secretions, but also by a perceptible increase in the content of IL-1alpha in the blood serum.
I I
II
Dolgushin
L F
LF
Telesheva
A Iu
AIu
Savochkina
O V
OV
Markina
D000328:Adult; D002582:Cervix Mucus / Q000737:chemistry / Q000276:immunology*; D016207:Cytokines / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000097:blood; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000276:immunology*; D047928:Premature Birth / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D002575:Uterine Cervicitis / Q000097:blood / Q000276:immunology*
D016207:Cytokines; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha