Medicinal application of long synthetic peptide technology.
This review covers the latest developments of long synthetic peptide technology for the rapid identification and development of malaria vaccine candidates and immunological modulators. A brief description of the two most common solid-phase synthetic procedures, together with the latest advances in optimisation of peptide chain assembly and analytical instrumentation, is given, with special attention to non-specialists. Several examples of vaccine candidates developed in the authors' or their collaborators' laboratories are also provided.
University of Lausanne, Department of Biochemistry, Epalinges, Switzerland. giampietro.corradin@ib.unil.ch
Giampietro
G
Corradin
Francois
F
Spertini
Antonio
A
Verdini
D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001514:Bee Venoms / Q000009:adverse effects / Q000201:enzymology / Q000276:immunology; D002625:Chemistry, Organic / Q000379:methods; D002986:Clinical Trials as Topic; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000517:prevention & control; D017780:Malaria Vaccines; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology / Q000627:therapeutic use*; D010741:Phospholipases A / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology; D010966:Plasmodium vivax / Q000276:immunology; D015800:Protozoan Proteins / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic
D000953:Antigens, Protozoan; D001514:Bee Venoms; D000939:Epitopes; D017780:Malaria Vaccines; D010455:Peptides; D015800:Protozoan Proteins; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D010741:Phospholipases A