Preparation and thermosensitivity of naturally occurring polypeptide poly(gamma-glutamic acid) derivatives modified by propyl groups.
Poly(gamma-glutamic acid) (gamma-PGA) is a biosynthetic polymer, and the carboxyl groups are able to undergo a chemical modification. In this study, poly(alpha-propyl gamma-glutamate) (gamma-PGA propylate) was synthesized by the esterification of these carboxyl groups to yield a thermosensitive and biodegradable polymer. In aqueous solution, the gamma-PGA propylate can impart thermosensitivity by controlling the hydrophobic-hydrophilic balance of the gamma-PGA polymeric chains.
Shimokuri
Taiki
T
Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan.
Kaneko
Tatsuo
T
Serizawa
Takeshi
T
Akashi
Mitsuru
M
D004355:Drug Stability; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D011099:Polyglutamic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D011422:Propionates; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D004952:Esters; D011422:Propionates; D011099:Polyglutamic Acid; C029658:propionic acid