Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.
We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.
Richette
Pascal
P
Federation de Rhumatologie, Hopital Lariboisiere, Paris, France. pascal.richette@lrb.ap-hop-paris.fr
Dieudé
Philippe
P
Damiano
Joël
J
Lioté
Frédéric
F
Orcel
Philippe
P
Bardin
Thomas
T
D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D009475:Neurons, Afferent / Q000473:pathology*; D011129:Polyradiculoneuropathy / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D020293:Vasculitis, Central Nervous System / Q000139:chemically induced / Q000473:pathology
D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab