[Effect of moxonidine on parameters of lipid metabolism in patients with metabolic syndrome.].
OBJECTIVE
To compare effects of moxonidine and lisinopril on parameters of lipid metabolism in patients with metabolic syndrome.


METHODS
Moxonidine (0.2-04 mg/day) and lisinopril (10-20 mg/day) were given to 25 and 24 patients, respectively. Blood pressure, heart rate, parameters of lipid profile and fasting blood glucose were measured before and after 12 weeks of treatment.


RESULTS
Antihypertensive efficacy of 2 drugs was similar. No changes of lipid profile occurred in lisinopril treated patients while significant elevation of high density lipoprotein cholesterol and tendency to lowering of triglyceride level were observed in moxonidine group.


CONCLUSIONS
Therapy with moxonidine was associated with favorable changes of lipid profile.
Anichkov
D A
DA
Russian State Medical University; ul. Ostrovityanova, 1, 117437 Moscow, Russia.
Shostak
N A
NA
D000959:Antihypertensive Agents; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D050356:Lipid Metabolism; D017706:Lisinopril; D024821:Metabolic Syndrome
D000959:Antihypertensive Agents; D017706:Lisinopril