One thing leads to another.
In 1956, the JCI published an article by Vincent Dole on a method for titrating plasma fatty acids that uncovered the importance of fatty acids as a substrate for glucose metabolism. When asked to prepare a historical perspective on this very popular paper, I paid Dole a visit and we reminisced. His answer to my question of how he came to do this work on plasma fatty acids was: "Well, one thing leads to another." Let me remind the reader of what "things" were like in 1956 and how they might have related to Dole's important contribution.
Hirsch
Jules
J
D001774:Blood Chemical Analysis / Q000266:history* / Q000379:methods; D004734:Energy Metabolism; D005227:Fatty Acids / Q000097:blood* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D014481:United States
D005227:Fatty Acids; D005947:Glucose