High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide.
A novel continuous-flow scCO(2) process for kinetic resolution of racemic alcohols can be performed with an immobilized lipase to lead to a quantitative mixture of the corresponding optically active acetates with up to 99% ee and unreacted alcohols with up to 99% ee, in which the productivity of the optically active compounds was improved by over 400 times compared to the corresponding batch reaction using scCO(2).
Matsuda
Tomoko
T
Department of Materials Chemistry, Ryukoku University, Otsu, Shiga 520-2194, Japan.
Watanabe
Kazunori
K
Harada
Tadao
T
Nakamura
Kaoru
K
Arita
Yoshitaka
Y
Misumi
Yukihiro
Y
Ichikawa
Shinichiro
S
Ikariya
Takao
T
D000438:Alcohols / Q000737:chemistry* / Q000302:isolation & purification; D002175:Candida / Q000201:enzymology; D002245:Carbon Dioxide / Q000737:chemistry*; D007700:Kinetics; D008049:Lipase / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D002245:Carbon Dioxide; D008049:Lipase