Universal high-level primary metronidazole resistance in Helicobacter pylori isolated from children in Egypt.
Antimicrobial susceptibility testing was performed on 48 isolates of Helicobacter pylori recovered from Egyptian children undergoing routine endoscopies. The isolates were universally highly resistant to metronidazole, but resistance to other tested antimicrobial agents was rare (4% for clarithromycin, erythromycin, and azithromycin resistance versus 2% for ciprofloxacin and ampicillin resistance). Use of metronidazole for the treatment of H. pylori in Egypt should be avoided.
Sherif
May
M
Naval Medical Research Unit No. 3, Cairo, Egypt.
Mohran
Zaynab
Z
Fathy
Hanan
H
Rockabrand
David M
DM
Rozmajzl
Patrick J
PJ
Frenck
Robert W
RW
D000293:Adolescent; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D004534:Egypt; D004724:Endoscopy; D005260:Female; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D008795:Metronidazole