Nutritional status and oxidative processes in diabetic and nondiabetic peritoneal dialysis patients.
OBJECTIVE
The purpose of our study was to compare the level of malonyldialdehyde (MDA) and carbonyl groups (GC) in diabetic and nondiabetic peritoneal dialysis patients.


METHODS
Prospective, observational study on peritoneal dialysis patients in a teaching hospital dialysis unit.


METHODS
A total of 21 diabetic and 66 nondiabetic patients treated with peritoneal dialysis were examined in the study. Main outcome measures The assessment of nutritional status was determined by clinical, anthropometric, and biochemical methods. The GC content was determined by the 2,4-dinitrophenylohydrazine assay using the Garibaldi method. The MDA was measured using the colorimetric method (LPO-586).


RESULTS
The plasma content of the GC and the MDA of peritoneal dialysis patients was significantly higher than in the healthy group (2.0 +/- 1.3 versus 1.3 +/- 0.4 nmol/mg protein and 3.8 +/- 1.4 versus 3.0 +/- 1.2 micromol/L). Moreover, the tendency toward increased levels of MDA and GC in the diabetic group in comparison with the nondiabetic group was noticed. Also, the highest values of GC and MDA were observed in severely malnourished patients.


CONCLUSIONS
The increase in oxidative stress may be related to a degree of malnutrition.
Department of Clinical Nutrition and Diagnostic Laboratory, Medical University of Gdansk, Gdansk, Poland. lysiak@amg.gda.pl
Sylwia
S
Malgorzewicz
Monika
M
Lichodziejewska-Niemierko
Boleslaw
B
Rutkowski
Wieslawa
W
Lysiak-Szydlowska
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D001823:Body Composition; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000175:diagnosis; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010530:Peritoneal Dialysis; D012709:Serum Albumin / Q000032:analysis
D001798:Blood Proteins; D012709:Serum Albumin; D008315:Malondialdehyde; D002784:Cholesterol