The complete genomic sequence of Nocardia farcinica IFM 10152.
We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.
Ishikawa
Jun
J
Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan. jun@nih.go.jp
Yamashita
Atsushi
A
Mikami
Yuzuru
Y
Hoshino
Yasutaka
Y
Kurita
Haruyo
H
Hotta
Kunimoto
K
Shiba
Tadayoshi
T
Hattori
Masahira
M
D000595:Amino Acid Sequence; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D009615:Nocardia / Q000235:genetics*; D012319:RNA Polymerase II / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D012319:RNA Polymerase II