[Dinitrosyl iron complexes are endogenous signaling agents in animal and human cells and tissues (a hypothesis)].
The hypothesis was advanced that dinitrosyl iron complexes generated in animal and human cells and tissues producing nitric oxide can function as endogenous universal regulators of biochemical and physiological processes. This function is realized by the ability of dinitrosyl iron complexes to act as donors of free nitric oxide molecules interacting with the heme groups of proteins, nitrosonium ions, or Fe+(NO+)2 interacting with the thiol groups of proteins. The effect of dinitrosyl iron complexes on the activity of some enzymes and the expression of the genome at the translation and transcription levels was considered.
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D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007501:Iron / Q000502:physiology*; D009589:Nitrogen Oxides; D013438:Sulfhydryl Compounds / Q000502:physiology
D009589:Nitrogen Oxides; D013438:Sulfhydryl Compounds; C073661:dinitrosyl iron complex; D007501:Iron