Epstein-Barr virus-associated peripheral T-cell lymphoma and hemophagocytic syndrome arising after liver transplantation: case report and review of the literature.
Post-transplantation lymphoproliferative disorders (PTLD) are a well-recognized complication of solid organ transplantation. The vast majority of PTLD are Epstein-Barr virus (EBV)-related infections that manifest as B-cell malignancies. We report an unusual case of an EBV-associated T-cell lymphoma in a 10-year-old boy who had previously undergone liver transplantation at age 4 years. He presented with hemophagocytic syndrome (HPS) and active EBV infection, with positive serum titers and polymerase chain reaction (PCR) for EBV in blood, colon, and antral samples.
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA. tigeorge@stanford.edu
Tracy I
TI
George
Michael
M
Jeng
William
W
Berquist
Athena M
AM
Cherry
Michael P
MP
Link
Daniel A
DA
Arber
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000209:etiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology*; D006801:Humans; D016130:Immunophenotyping; D016031:Liver Transplantation; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications