Endovascular management of iliofemoral deep venous thrombosis due to iliac vein compression syndrome in patients with protein C and/or S deficiency.
The purpose of this study was to evaluate the early outcome of endovascular management in patients with iliofemoral deep venous thrombosis (DVT) due to iliac vein compression syndrome (IVCS) and protein C and/or S deficiency. Between September 2000 and January 2003, catheter-directed thrombolysis was performed in 11 patients with a diagnosis of acute iliofemoral DVT: 7 with protein C and/or S deficiency and 4 without protein C and/or S deficiency. After thrombolysis, the diagnosis of IVCS was confirmed in 6 patients: 4 with protein C and/or S deficiency and 2 without protein C and/or S deficiency. Further intervention consisted of angioplasty and stent placement was performed. Four patients with IVCS and protein C and/or S deficiency were included in this study. The immediate technical and clinical success rates were 100% in all 4 patients. There were no complications or clinically detectable pulmonary emboli. This initial experience suggests that endovascular management of iliofemoral DVT due to IVCS in patients with protein C and/or S deficiency is safe and effective.
Department of Surgery, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea. ypcho@gnah.co.kr.
Yong Pil
YP
Cho
Je-Hong
JH
Ahn
Soo-Jung
SJ
Choi
Myoung Sik
MS
Han
Hyuk Jai
HJ
Jang
Yong Ho
YH
Kim
Hee Jeong
HJ
Kim
Tae-Won
TW
Kwon
Sung Gyu
SG
Lee
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007084:Iliac Vein; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000008:administration & dosage; D020151:Protein C Deficiency / Q000150:complications*; D018455:Protein S Deficiency / Q000150:complications*; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage; D020246:Venous Thrombosis / Q000150:complications* / Q000188:drug therapy*
D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator