ParIS Genome Rearrangement server.
ParIS Genome Rearrangement is a web server for a Bayesian analysis of unichromosomal genome pairs. The underlying model allows inversions, transpositions and inverted transpositions. The server generates a Markov chain using a Partial Importance Sampler technique, and samples trajectories of mutations from this chain. The user can specify several marginalizations to the posterior: the posterior distribution of number of mutations needed to transform one genome into another, length distribution of mutations, number of mutations that have occurred at a given site. Both text and graphical outputs are available. We provide a limited server, a downloadable unlimited server that can be installed locally on any linux/Unix operating system, and a database of mitochondrial gene orders.
Theoretical Biology and Ecology Modelling Group, Hungarian Academy of Sciences and Eötvös Loránd University, Pázmány Péter Sétány 1/c. H-1117 Budapest, Hungary. miklosi@ramet.elte.hu
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D000465:Algorithms; D002869:Chromosome Aberrations; D002874:Chromosome Mapping / Q000379:methods*; D004252:DNA Mutational Analysis / Q000379:methods*; D020407:Internet; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software