Successful treatment of hypersensitivity pneumonitis caused by Grifola frondosa (Maitake) mushroom using a HFA-BDP extra-fine aerosol.
We successfully treated a patient with occupational hypersensitivity pneumonitis (HP) caused by Grifola frondosa (Maitake) mushroom spore with an extra-fine aerosol corticosteroid; beclomethasone dipropionate (BDP) dissolved in hydrofluoroalkane-134a (HFA). A 49-year-old woman developed respiratory symptoms 3 months after beginning work on a mushroom farm. She was diagnosed as HP based on radiological and serological findings. Oral prednisolone therapy improved her HP and she returned to the same farm. Her HP relapsed after 5 months, and daily 400 microg of HFA-BDP was administered with gradual improvement. An extra-fine particle inhaled corticosteroid might reach appropriate alveoli to be effective therapy for mild HP.
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543.
Hiroshi
H
Tanaka
Kazunori
K
Tsunematsu
Naohito
N
Nakamura
Kazuhiko
K
Suzuki
Nobuyuki
N
Tanaka
Isao
I
Takeya
Toyohiro
T
Saikai
Shosaku
S
Abe
D000280:Administration, Inhalation; D000335:Aerosol Propellants; D000363:Agaricales / Q000276:immunology*; D000382:Agricultural Workers' Diseases / Q000188:drug therapy* / Q000276:immunology*; D000542:Alveolitis, Extrinsic Allergic / Q000188:drug therapy* / Q000276:immunology*; D001507:Beclomethasone / Q000008:administration & dosage; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000008:administration & dosage; D008875:Middle Aged; D013172:Spores, Fungal / Q000276:immunology; D005466:Fluorocarbons
D000335:Aerosol Propellants; D001507:Beclomethasone; D005938:Glucocorticoids; D006845:Hydrocarbons, Fluorinated; C094049:apaflurane; D005466:Fluorocarbons