Antimicrobial prophylaxis in solid-organ transplantation.
Solid-organ transplantation has become a widely accepted treatment modality for end-stage diseases. With the advent of newer and more potent immunosuppressive regimens, graft survival has improved, but at the expense of an increased risk for the development of infections secondary to bacterial, fungal, viral and parasitic pathogens. Prevention of such infectious complications with effective, well-tolerated and cost-effective antimicrobials would be ideal to improve the outcome of transplant patients. Cytomegalovirus is the most common cause of viral infections. Herpes simplex virus, Varicella-zoster virus, Epstein-Barr virus and others are also significant pathogens. Fungal infections are associated with the highest mortality rates. This review summarizes the most relevant data pertaining to the current understanding of infection prevention for solid-organ transplant recipients.
Ospedale Università, Clinica Malattie Infettive, A.O. San Martino di Genova, Largo R.Benzi 10, 16132 Genova, Italy. mattba@tin.it
Matteo
M
Bassetti
Elda
E
Righi
Dante
D
Bassetti
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001424:Bacterial Infections / Q000150:complications / Q000517:prevention & control; D006801:Humans; D009181:Mycoses / Q000150:complications / Q000517:prevention & control; D016377:Organ Transplantation / Q000009:adverse effects*; D010272:Parasitic Diseases / Q000150:complications / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D014777:Virus Diseases / Q000150:complications / Q000517:prevention & control
D000890:Anti-Infective Agents