PHEMA hydrogels obtained by a novel low-heat curing procedure with a potential for in situ preparation.
In this work, we report on poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels obtained by a low heat curing reaction. These materials are suitable for in situ preparation and therefore endowed with a potential for several biomedical applications. The novel procedure adopted involves as the first step the synthesis of a soluble oligomeric PHEMA precursor containing polymerizable functions as side substituents. As the second step, the precursor is dissolved in equal amounts of 2-hydroxyethyl methacrylate (HEMA) and water, to form a viscous but still injectable syrup. A low temperature water soluble initiator is then added. The curing reaction starts promptly and is completed within few minutes. During the entire process the internal temperature never rises above 40 degrees C. Preliminary mechanical characterizations performed on the hydrogels in their water-swollen state and diffusion tests in absorption/desorption experiments clearly indicated that on all respects the novel hydrogels are comparable with conventional PHEMA hydrogels obtained according to literature from HEMA in the presence of divinyl crosslinkers. However, the much shorter curing time combined with the far lower curing temperature endow the new hydrogels with a higher potential in view of specific surgical requirements, and particularly for in situ preparation.
Dipartimento di Chimica Organica e Industriale, via Venezia 21, 20123 Milan, Italy.
Paolo
P
Ferruti
Michela
M
Grigolini
Elisabetta
E
Ranucci
D000042:Absorption; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D006358:Hot Temperature; D020100:Hydrogels / Q000138:chemical synthesis*; D011102:Polyhydroxyethyl Methacrylate / Q000138:chemical synthesis*; D019736:Prostheses and Implants; D014867:Water
D001672:Biocompatible Materials; D020100:Hydrogels; D014867:Water; D011102:Polyhydroxyethyl Methacrylate