A prospective study linked both alcohol and tobacco to Dupuytren's disease.
OBJECTIVE
To address the role of alcohol intake and tobacco smoking and the combination of the two on subsequent risk of Dupuytren's disease.


METHODS
Cohort study of 7,254 subjects enrolled in the Copenhagen City Heart Study (1981-1983). Both self-reported information on lifestyle and objective measures at the baseline examination were linked to presence of Dupuytren's disease at a subsequent examination (1991-1994) using multivariate logistic regression analysis.


RESULTS
A total of 772 subjects had signs of Dupuytren's disease at follow-up. After adjustment for age, sex, educational level, diabetes, and either alcohol or tobacco consumption, respectively, odds ratios for having the disease increased in a dose-dependent manner with increasing levels of alcohol or tobacco intake; however, there was no statistical interaction between heavy smoking and heavy drinking.


CONCLUSIONS
Alcohol intake and tobacco smoking are independently associated with increased risk of Dupuytren's disease, and the combination of the two conveys a very large risk.
Copenhagen Centre for Prospective Population Studies, Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen University Hospital, Svanemøllevej 25, DK-2100 Copenhagen, Denmark.
Nina S
NS
Godtfredsen
Hasse
H
Lucht
Eva
E
Prescott
Thorkild I A
TI
Sørensen
Morten
M
Grønbaek
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects*; D003718:Denmark / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D004387:Dupuytren Contracture / Q000453:epidemiology / Q000209:etiology*; D004812:Epidemiologic Methods; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects*
D000431:Ethanol