The potential of antispermatogenic drugs against trypanosomatids.
In recent years, two antispermatogenic drugs - gossypol and lonidamine (Fig. I) - have been reported to inhibit the growth of Trypanosoma cruzi in culture. In this article, Julio Turrens discusses the biochemical similarities between trypanosomatids and spermatozoa. and the potential o f these antispermatogenic drugs against the parasites.
Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 1113 Bs.As, Argentina.
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Turrens