Primary myelofibrosis terminated in basophilic leukemia and successful allogeneic bone marrow transplantation.
Transformation of primary myelofibrosis (PMF) to basophilic leukemia is very rare. We report the case of a 44-year-old man who had had PMF for 6 years. His hematopoiesis deteriorated with marked splenomegaly, requiring multiple red blood cell and platelet transfusions. Soon after splenectomy, progressive basophilia (32.3 x 10(9)/L) developed, infiltrating the skin as well as the bone marrow. The patient underwent allogeneic bone marrow transplantation with cells from an HLA-matched sibling. Despite the presence of hyperhistaminemia (99.1 ng/mL) after conditioning with cyclophosphamide, the pregrafting and post-grafting periods were uneventful. Prophylactic administration of both H1 and H2 receptor antagonists and sufficient hydration appeared to be important.
Sugimoto
Naoshi
N
Department of Hematology and Clinical Immunology, Kobe City General Hospital, Kobe, Japan.
Ishikawa
Takayuki
T
Gotoh
Saori
S
Shinzato
Isaku
I
Matsushita
Akiko
A
Nagai
Kenichi
K
Ohgoh
Noriko
N
Takahashi
Takayuki
T
D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000379:methods* / Q000473:pathology; D006410:Hematopoiesis; D006801:Humans; D015471:Leukemia, Basophilic, Acute / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications* / Q000473:pathology