B7-H1-targeted immunotherapy for head and neck cancer.
Manipulation of defined costimulatory pathways may provide a means to direct the immune response against head and neck cancer. Three broad hurdles serve as relative obstacles to effective clinical translation of reagents designed to alter costimulatory function. First is an expanding, but still limited, understanding of the biological function of each individual costimulatory pathway. Second is the paucity of reagents suitable for clinical application. Third is the limited number of valid model systems to evaluate the utility of these novel reagents prior to clinical intervention. This review focuses on the role of a recently discovered costimulatory molecule, B7-H1, as a model for the development of novel strategies for immunotherapy of head and neck cancer.
Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Xiaoyu
X
Zhang
Scott E
SE
Strome
D000069594:Abatacept; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000187:drug effects / Q000276:immunology; D000954:Antigens, Surface / Q000502:physiology; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D018122:B7-1 Antigen / Q000187:drug effects* / Q000276:immunology; D060908:CTLA-4 Antigen; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000628:therapy*; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology; D018450:Disease Progression; D006258:Head and Neck Neoplasms / Q000276:immunology / Q000628:therapy*; D006801:Humans; D018796:Immunoconjugates / Q000494:pharmacology / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008546:Melanoma, Experimental / Q000276:immunology / Q000628:therapy; D051379:Mice; D009369:Neoplasms / Q000628:therapy; D061026:Programmed Cell Death 1 Receptor; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D019139:Tumor Escape
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D018122:B7-1 Antigen; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C556707:Ctla4 protein, mouse; D018796:Immunoconjugates; C105992:PDCD1 protein, human; C491383:Pdcd1 protein, mouse; D061026:Programmed Cell Death 1 Receptor; D000069594:Abatacept