Interactions of poly(amidoamine) dendrimers with the surfactants SDS, DTAB, and C12EO6: an equilibrium and structural study using a SDS selective electrode, isothermal titration calorimetry, and small angle neutron scattering.
Interactions in aqueous solutions of different generations of poly(amidoamine) (PAMAM) dendrimers containing amine, hydroxyl, or delta-glucolactone functional groups at the periphery with the anionic surfactant sodium dodecyl sulfate (SDS) were investigated. We used a SDS-specific electrode (EMF) for SDS monomer concentration monitoring, isothermal titration calorimetry (ITC) for binding information, and small angle neutron scattering (SANS) for structural studies. ITC experiments monitoring the interaction of the dendrimers with cationic dodecyltrimethylammonium bromide (DTAB) and nonionic hexaethylene glycol mono-n-dodecyl ether (C12EO6) showed no significant binding effects. In contrast, SDS binds to all of the above dendrimers. EMF and ITC data demonstrated a regular trend for both the onset of binding and binding saturation as the generation in each family of dendrimers increased. In addition, generation G6 exhibited a noncooperative binding process at very low SDS concentrations. Furthermore, the onset of cooperative binding in the EMF experiments started at lower concentrations as the weight % (w/v), the size, and the numbers of the internal or surface groups increased. On the other hand, the binding capacity of the dendrimers showed only a small dependence on the above parameters. At SDS concentrations approaching the binding limit and also at selective concentrations within the binding range, SANS measurements indicated that in all cases the bound surfactant is in the micellar form. From the electromotive force (EMF) measurements, ITC data, and SANS data, the stoichiometry of the supramolecular complexes was determined.
School of Chemical Sciences, Science Research Institute, University of Salford, Salford M5 4WT, UK.
J
J
Sidhu
The Late D M
TL
Bloor
S
S
Couderc-Azouani
J
J
Penfold
J F
JF
Holzwarth
E
E
Wyn-Jones
D002151:Calorimetry / Q000379:methods; D050091:Dendrimers / Q000737:chemistry*; D004566:Electrodes; D004987:Ethers / Q000737:chemistry*; D006018:Glycols / Q000737:chemistry*; D015394:Molecular Structure; D033363:Neutron Diffraction / Q000379:methods; D011073:Polyamines / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D017186:Titrimetry
D050091:Dendrimers; D004987:Ethers; D006018:Glycols; D011073:Polyamines; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; C509668:hexaethylene glycol mono-n-dodecyl ether; D012967:Sodium Dodecyl Sulfate; C022806:dodecyltrimethylammonium