Age-related differences in auditory event-related potentials during a cued attention task.
OBJECTIVE
To determine if aging is associated with differences in attentional regulation using behavioral and event-related potential (ERP) measures.


METHODS
Younger (n=13;M=20 years) and older (n=12;M=76 years) subjects performed an auditory cued attention task. Verbal cues correctly (valid) or incorrectly (invalid) predicted the ear receiving a target tone 1.5 s later, or were uninformative (neutral). Targets were either 'high' (2000 Hz) or 'low' (1000 Hz) pitch monaural tones. Subjects pressed one of 4 buttons to indicate target ear and pitch. ERPs following cues and targets (P50, N100, P200, slow waves), and negative slow potentials (CNV) between cues and targets were assessed.


RESULTS
Cue information had significant effects on reaction time for both groups (valid<neutral<invalid). Target N100 amplitude was significantly affected by cueing in younger (invalid>valid) but not older subjects. Target slow waves were also affected by cue information (invalid>valid), and the difference was larger and lasted longer in older subjects. Slow waves following cues were significantly larger in older subjects, but the subsequent CNV amplitudes were comparable among groups.


CONCLUSIONS
When performing a cued attention task, age differences are present in transient ERPs following cues and targets.


CONCLUSIONS
Age differences in ERPs associated with attentional regulation support the hypothesis that attentional changes contribute to cognitive aging.
Department of Neurology, Institute for Brain Aging and Dementia, University of California, 154 Med Surge I, Irvine, CA 92697, USA.
Ilana J
IJ
Bennett
Edward J
EJ
Golob
Arnold
A
Starr
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology* / Q000523:psychology*; D001288:Attention; D003265:Contingent Negative Variation; D003463:Cues; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time