Soymilk intake is associated with plasma and liver lipid profiles in rats fed a high-cholesterol diet.
OBJECTIVE
This study investigated the effects of soymilk on lipid metabolism in Sprague-Dawley rats fed a cholesterol-enriched (0.3%) diet.


METHODS
Thirty male Sprague-Dawley rats weighing 230.0 +/- 9.8 g were randomly assigned to one of three groups: control, S1 (containing 15% soymilk powder in the diet), and S2 (22.5%). After 8 wk, lipid profiles of the plasma, liver, and feces were determined.


RESULTS
Body weight gain, daily food intake, and feeding efficiency showed no differences across groups (P > 0.05). The experimental groups had significantly lower plasma levels of cholesterol, triacylglycerol, and low-density lipoprotein cholesterol than the control group (P < 0.05) at weeks 4 and 8. However, total fecal excretion of neutral steroid did not significantly differ across groups (P > 0.05).


CONCLUSIONS
Soymilk affects the metabolism of plasma cholesterol in Sprague-Dawley rats.
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China.
Jiun-Rong
JR
Chen
Shih-Ming
SM
Liu
Suh-Ching
SC
Yang
Kunio
K
Suetsuna
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D041942:Soy Milk / Q000008:administration & dosage* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol