No effect of bovine interferon-tau for control of calf diarrhea and immunomodulation in calves.
Newborn calves received a low dose of bovine interferon-tau (boIFN-tau) orally for 4 weeks and calves that had developed diarrhea received a low dose of boIFN-tau orally for 5 days. No effects of boIFN-tau were seen in the duration of the diarrhea, or in daily weight gain. Calves received a high dose of boIFN-tau subcutaneously 3 times and they were then stimulated with bovine herpesvirus type 1 vaccine. No adverse effects were observed after the administration of boIFN-tau and lymphocyte subsets from calves did not change after the stimulation. Our results suggest that boIFN-tau does not seem protecting for preventing calves from diarrhea, recovering the health of calves with diarrhea or immunomodulation, although the treatment itself is not toxic.
Hokkaido Animal Research Center, Shintoku, hokkaido, Japan.
Junko
J
Kohara
Chizuru
C
Yayota
Yuichi
Y
Yokomizo
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000188:drug therapy*; D003967:Diarrhea / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D007370:Interferon Type I / Q000276:immunology / Q000627:therapeutic use*; D018655:Lymphocyte Count / Q000662:veterinary; D011257:Pregnancy Proteins / Q000276:immunology / Q000627:therapeutic use*; D013997:Time Factors
D007370:Interferon Type I; D011257:Pregnancy Proteins; C020947:interferon tau