Metastasizing and non-metastasizing tumors likely evolve from DNA phenotypes via independent pathways.
We have recently discovered, using statistical models of Fourier transform-infrared spectra, two distinct cancer DNA phenotypes in histologically normal tissues surrounding non-metastasizing primary tumors and tumors with evidence of distant metastases. Structural comparisons of the DNA from these tumor types imply that each evolves via a separate pathway from DNA phenotypes originating in progenitor cells. These findings challenge the widely-held concept of metastasis.
Malins
Donald C
DC
Biochemical Oncology Program, Pacific Northwest Research Institute, Seattle, Washington 98122, USA. dmalins@pnri.org
D000818:Animals; D004273:DNA, Neoplasm / Q000235:genetics*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D010641:Phenotype
D004273:DNA, Neoplasm