Speckled lentiginous nevus syndrome: report of a further case.
A 42-year-old man had a large speckled lentiginous nevus on the left side of his trunk. The involved area was painful when touched and paresthetic. Moreover, the ipsilateral half of his body showed a pronounced hyperhidrosis. This case can be categorized as a typical example of speckled lentiginous nevus syndrome, a recently recognized phenotype characterized by a speckled lentiginous nevus of the papular type and ipsilateral neurological abnormalities in the form of dysesthesia, muscular weakness or hyperhidrosis. Speckled lentiginous nevus syndrome represents a mosaic phenotype. Most likely it originates from loss of heterozygosity occurring in a heterozygous embryo at an early developmental stage.
Vente
Claudia
C
Department of Dermatology, Georg August University, Göttingen, Germany.
Neumann
Christine
C
Bertsch
Hans
H
Rupprecht
Rainer
R
Happle
Rudolf
R
D000328:Adult; D006801:Humans; D006945:Hyperhidrosis / Q000150:complications; D008297:Male; D020752:Neurocutaneous Syndromes / Q000175:diagnosis* / Q000473:pathology; D009508:Nevus, Pigmented / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013577:Syndrome