Antimicrobial susceptibility of Helicobacter pylori strains isolated in Bangladesh.
Antimicrobial susceptibility of 120 Helicobacter pylori isolates to metronidazole, tetracycline, clarithromycin, and amoxicillin was determined, and 77.5, 15, 10, and 6.6% of the isolates, respectively, were resistant. Only rdxA inactivation and both rdxA and frxA inactivation were responsible for metronidazole resistance in 66% (8 of 12) and 33% (4 of 12) of the isolates, respectively.
Nahar
Shamsun
S
International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Mukhopadhyay
Asish K
AK
Khan
Rasel
R
Ahmad
Mian Mashhud
MM
Datta
Simanti
S
Chattopadhyay
Santanu
S
Dhar
Swapan Chandra
SC
Sarker
Shafiqul Alam
SA
Engstrand
Lars
L
Berg
Douglas E
DE
Nair
G Balakrish
GB
Rahman
Motiur
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D001459:Bangladesh / Q000453:epidemiology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009601:Nitroreductases / Q000235:genetics
D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D008795:Metronidazole; D009601:Nitroreductases; C476646:RdxA protein, Helicobacter pylori