[A role of lipid peroxidation in postoperative impairments of thrombocytic hemostasis in patients with lung cancer].
The paper analyzes the time course of changes in spontaneous platelet aggregation (SPA), malonic dialdehyde (MDA) levels, and overall blood antioxidative capacity in the sera of patients with lung cancer after surgical treatment. The laboratory signs of impaired lipid peroxidation are shown to form by postoperative days 7 to 14. Depletion of the activity of antioxidants is followed by the elevated blood levels of MDA and may an additional factor of enhanced SPA. The use of antioxidants on postoperative days 7 to 14 will assist in avoiding the depletion of the antioxidative system. The efficiency of this therapy may be evaluated from SPA.
A N
AN
Afanas'eva
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Udut
V A
VA
Evtushenko
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010974:Platelet Aggregation / Q000502:physiology*; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000188:drug therapy; D013997:Time Factors
D000975:Antioxidants; D008315:Malondialdehyde