Aminoboranes as "compatible" iminium ion generators in aminative C-C bond formations.
Aminoboranes have been shown to be highly efficient and mild iminium ion generators in the Mannich-type aminative coupling of aldehydes with silyl ketene acetals. By using aminoboranes bearing bulky amino groups, such as a diisopropylamino group, free secondary amines can be successfully used as the amino component in a three-component Mannich reaction with aldehydes and silyl ketene acetals.
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, PRESTO, Japan Science and Technology Corporation, Katsura, Kyoto 615-8510, Japan. suginome@sbchem.kyoto-u.ac.jp
Michinori
M
Suginome
Lars
L
Uehlin
Masahiro
M
Murakami