Genetic determinants of platelet function in thromboembolic diseases.
Within the past decade our understanding of thromboembolic disorders has become even more sophisticated as recent discoveries have suggested the influence of gene variants on the development of atherosclerotic disease and arterial thrombosis. Candidate genes encode proteins involved in processes relevant to atherosclerosis, ranging from cholesterol metabolism to arterial thrombosis. Platelets are key elements in primary hemostasis, but also in arterial thrombosis. Moreover, a number of genetic polymorphisms of platelet proteins may also induce gain or loss of function, supporting a role predisposing some individuals to thrombotic events. However, after thousands of studies, much controversy remains whether individual platelet polymorphisms contribute to an increased likelihood of thromboembolic disorders. Although platelet polymorphisms are a promising addition to more established cardiovascular risk factors, identifying genetic variants as a single cause of cardiovascular disease would be an oversimplification; instead, the contribution of these polymorphisms should also be considered in the context of a multifactorial disease. Gene-gene and gene-environment studies would identify specific combinations associated with a high risk to suffer from these diseases. The platelet's genetic heterogeneity should also be considered in every aspect of clinical medicine, ranging from susceptibility to diseases, pathogenesis, and clinical outcome to diversity in responses to drug treatment (pharmacogenomics), and bleeding.
University of Murcia, Department of Medicine, Centro Regional de Hemodonación, Murcia, Spain. javier.corral@carm.es
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D017304:Annexin A5 / Q000235:genetics; D015703:Antigens, CD / Q000235:genetics; D001792:Blood Platelets / Q000502:physiology*; D002864:Chromogranins; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D005787:Gene Frequency; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D008954:Models, Biological; D019007:P-Selectin / Q000235:genetics; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics; D013923:Thromboembolism / Q000235:genetics*
D017304:Annexin A5; D015703:Antigens, CD; D002864:Chromogranins; C080568:Fc gamma receptor IIA; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein; D017452:Receptors, IgG; C406732:GNAS protein, human; D019205:GTP-Binding Protein alpha Subunits, Gs