DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus.
The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo.
Institute for Clinical and Molecular Virology, University Erlangen-Nürnberg, Nikolaus-Fiebiger-Center, Glückstrasse 6, D-91054 Erlangen, Germany.
Andrea
A
Marzi
Thomas
T
Gramberg
Graham
G
Simmons
Peggy
P
Möller
Andrew J
AJ
Rennekamp
Mandy
M
Krumbiegel
Martina
M
Geier
Jutta
J
Eisemann
Nadine
N
Turza
Bertrand
B
Saunier
Alexander
A
Steinkasserer
Stephan
S
Becker
Paul
P
Bates
Heike
H
Hofmann
Stefan
S
Pöhlmann
D015815:Cell Adhesion Molecules / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology*; D037181:Lectins, C-Type / Q000502:physiology*; D029024:Marburgvirus / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000502:physiology*; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000502:physiology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human; C578557:spike glycoprotein, SARS-CoV; C578553:spike protein, mouse hepatitis virus