Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers.
The forearm blood flow (FBF) responses to acetylcholine and to sodium nitroprusside were evaluated before and after administration of edaravone in 10 smokers and 10 nonsmokers. FBF response to acetylcholine was lower in smokers than in nonsmokers. The vasodilatory effects of sodium nitroprusside were similar in both groups. Co-infusion of edaravone increased the FBF response to acetylcholine in smokers, but did not affect the FBF response to acetylcholine in nonsmokers. The administration of N(G)-monomethyl-l-arginine abolished edaravone-induced augmentation of the FBF response to acetylcholine in smokers. The antioxidative agent edaravone increases nitric oxide mediated vasodilation through a decrease in oxidative stress.
Department of Cardiovascular Physiology and Medicine, Hiroshima University, Hiroshima, Japan.
Daisuke
D
Jitsuiki
Yukihito
Y
Higashi
Chikara
C
Goto
Masashi
M
Kimura
Kensuke
K
Noma
Keiko
K
Hara
Keigo
K
Nakagawa
Tetsuya
T
Oshima
Kazuaki
K
Chayama
Masao
M
Yoshizumi
D000109:Acetylcholine / Q000494:pharmacology; D000328:Adult; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000077553:Edaravone; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D012907:Smoking / Q000503:physiopathology*; D014664:Vasodilation / Q000187:drug effects*; D019323:omega-N-Methylarginine / Q000494:pharmacology
D016166:Free Radical Scavengers; D009599:Nitroprusside; D019323:omega-N-Methylarginine; D000109:Acetylcholine; D000077553:Edaravone; D000983:Antipyrine