Hydrogel formation between enantiomeric B-A-B-type block copolymers of polylactides (PLLA or PDLA: A) and polyoxyethylene (PEG: B); PEG-PLLA-PEG and PEG-PDLA-PEG.
A mixed suspension of the enantiomeric B-A-B triblock copolymers, polyoxyethylene-block-poly(L-lactide)-block-polyoxyethylene (PEG-PLLA-PEG) and polyoxyethylene-block-poly(D-lactide)-block-polyoxyethylene (PEG-PDLA-PEG), was found to induce reversible gel-to-sol transition depending on the polymer concentration and temperature. The storage and loss moduli of the gel formed at lower temperature were much higher than those of the gel prepared from the corresponding ABA-type triblock copolymers because of the higher polymer concentration in the former. Although the stereo-complexation of the PLLA and PDLA blocks occurred at higher temperature also in the B-A-B copolymers, it was not responsible for the gelation of the mixed suspension. The PEG chains, involved in the helix formation of the PLLA and PDLA, should form helices with opposite helical senses to aggregate and lead the gelation of the system.
Department Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
Takashi
T
Mukose
Tomoko
T
Fujiwara
Junko
J
Nakano
Ikuo
I
Taniguchi
Masatoshi
M
Miyamoto
Yoshiharu
Y
Kimura
Iwao
I
Teraoka
Chan
C
Woo Lee
D020100:Hydrogels / Q000737:chemistry*; D044367:Phase Transition; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D013696:Temperature
D020100:Hydrogels; D011091:Polyesters; D011108:Polymers; C499774:polyethylene glycol-polylactide-polyethylene glycol; D011092:Polyethylene Glycols; C033616:poly(lactide)