Exposure of mouse to high gravitation forces induces long-term potentiation in the hippocampus.
The central nervous system is highly plastic and has been shown to undergo both transient and chronic adaptive changes in response to environmental influences. The purpose of this study was to investigate the effect of hypergravic field on long-term potentiation (LTP) in the mouse hippocampus. Exposure of mice to 4G fields for 48 h had no effect on input-output coupling during extracellular stimulation of Schaffer collaterals and paired pulse facilitation, suggesting that the hypergravic exposure had no detrimental effect on basal neurotransmission in the hippocampus. However, the exposure to 4G fields for 48 h significantly induced LTP compared with the control mouse hippocampus. In contrast, no significant changes of late-phase LTP (L-LTP) were found in the hippocampi of mice exposed to the hypergravic field. Exposure of mice to 4G fields for 48 h enhanced AMPA receptor phosphorylation but not cyclic AMP-responsive element binding protein (CREB) phosphorylation. These results suggest that exposure to hyperdynamic fields influences the synaptic plasticity in the hippocampus.
Ishii
Masamitsu
M
Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan.
Tomizawa
Kazuhito
K
Matsushita
Masayuki
M
Matsui
Hideki
H
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D002498:Centrifugation / Q000295:instrumentation; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology*; D018471:Hypergravity; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009473:Neuronal Plasticity / Q000502:physiology; D010766:Phosphorylation; D018091:Receptors, AMPA / Q000378:metabolism
D017362:Cyclic AMP Response Element-Binding Protein; D018091:Receptors, AMPA