Antimicrobial activity of some pentacyclic triterpenes and their synthesized 3-O-lipophilic chains.
The major metabolites of Diopsyros melanoxylon viz. amyrins and ursolic acid and their lipophilic 3-O-fatty acid ester chains (C12-C18), which are synthesized now under mild esterification conditions in excellent yields (80-95%), were evaluated for their antimicrobial activity against a series of Gram positive and Gram negative bacteria. Significantly these compounds were found to exhibit potent activity against Gram negative bacteria Pseudomonas syringae (ATCC #13457) and fairly good activity against Gram positive bacteria, Bacillus sphaericus (ATCC #14577) and Bacillus subtilis (ATCC #6051).
Centre for Herbal Drugs Department, Regional Research Laboratory (CSIR), Bhubaneswar, Orissa, India. uvmavadani@rrlbhu.res.in
Uppuluri Venkata
UV
Mallavadhani
Anita
A
Mahapatra
Kaiser
K
Jamil
Peddi Srinivasa
PS
Reddy
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D029788:Diospyros; D004951:Esterification; D005227:Fatty Acids / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000097245:Ursolic Acid
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D009828:Oleanolic Acid; D010936:Plant Extracts; D014315:Triterpenes; D000097245:Ursolic Acid; C036380:beta-amyrin