Is secondary lymphoid-organ chemokine (SLC/CCL21) much more than a constitutive chemokine?
Chemokines are a superfamily of small cytokines with activities ranging from leukocyte traffick to hematopoiesis, angiogenesis, and tissue organogenesis. Secondary lymphoid-organ chemokine (SLC/CCL21) was originally reported as a chemokine constitutively expressed by stromal cells and high endothelial venules in secondary lymphoid tissues and endothelium of afferent lymphatics, directing CCR7+ cells. More recently, others and we have demonstrated that SLC/CCL21 is up-regulated in different skin inflammatory conditions. Thereafter, this molecule is much more than a constitutive chemokine, which could play a role in effector and regulatory immune functions.
Serra
H M
HM
Inmunología, Dpto. Bioquímica Clínica, Facultad de Ciencias Químicas--Universidad Nacional de Córdoba, Argentina.
Baena-Cagnani
C E
CE
Eberhard
Y
Y
D054421:Chemokine CCL21; D018925:Chemokines; D019742:Chemokines, CC / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology*
C515478:CCL21 protein, human; D054421:Chemokine CCL21; D018925:Chemokines; D019742:Chemokines, CC