[Patched/Sonic Hedgehog pathway and basal cell carcinoma].
The recent discovery of the role of the Patched Sonic Hedgehog pathway in the physiopathogeny of BCC (basocellular carcinoma) and Gorlin's syndrome has greatly improved our knowledge on the mechanism of development of these tumors. For the first time, murine models have been developed allowing to further understand other molecular events implicated in such tumors as well as providing in vivo models to search for new curative or preventive therapeutical strategies which would be helpful to control CBC multiple forms, that are often disabling.
Basset-Seguin
Nicole
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Inserm U.532, Institut de recherche sur la peau, Hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. nbs@chu-stlouis.fr
Soufir
Nadem
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D000230:Adenocarcinoma / Q000235:genetics*; D000818:Animals; D001478:Basal Cell Nevus Syndrome / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D000072079:Patched Receptors; D011956:Receptors, Cell Surface; D012878:Skin Neoplasms / Q000235:genetics
D008565:Membrane Proteins; D000072079:Patched Receptors; D011956:Receptors, Cell Surface