Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity.
Several studies have indicated that CD8(+) T cells require CD4(+) T cell help for memory formation. Evidence suggests that such help can be antigen independent, challenging whether the 'licensing' of dendritic cells (DCs) by CD4(+) T cells is ever required for cytotoxic T lymphocyte (CTL) responses. We show here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4(+) T cells mediate help in a cognate, antigen-specific way. We provide direct in vivo evidence for DC licensing by helper T cells and show that licensing is rapid and essential for the formation of effector and memory CTLs. In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing.
Division of Immunology, The Co-operative Research Centre for Vaccine Technology at The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.
Christopher M
CM
Smith
Nicholas S
NS
Wilson
Jason
J
Waithman
Jose A
JA
Villadangos
Francis R
FR
Carbone
William R
WR
Heath
Gabrielle T
GT
Belz
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D051379:Mice; D008954:Models, Biological; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000949:Histocompatibility Antigens Class II