Treponema pallidum fibronectin-binding proteins.
Putative adhesins were predicted by computer analysis of the Treponema pallidum genome. Two treponemal proteins, Tp0155 and Tp0483, demonstrated specific attachment to fibronectin, blocked bacterial adherence to fibronectin-coated slides, and supported attachment of fibronectin-producing mammalian cells. These results suggest Tp0155 and Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions.
Box 357185, Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, WA 98195, USA. caroc@u.washington.edu.
Caroline E
CE
Cameron
Elizabeth L
EL
Brown
Janelle M Y
JM
Kuroiwa
Lynn M
LM
Schnapp
Nathan L
NL
Brouwer
D018829:Adhesins, Bacterial; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D014210:Treponema pallidum / Q000472:pathogenicity / Q000502:physiology
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D002352:Carrier Proteins; D005353:Fibronectins; D011994:Recombinant Proteins; C078635:fibronectin-binding proteins, bacterial