The role of asymmetry of nervous and immune systems in the formation of cellular immunity of (CBaxC57Bl/6) F1 mice.
We have previously shown the existence of functional asymmetry of the immune system and the role of brain hemispheres and different lobes of thymus in the development of humoral immune response in (CBA x C57Bl/6) F1 mice. The role of asymmetry of the nervous and immune systems in the formation of the cellular immune response [delayed-type hypersensitivity (DTH) reaction] in these mice has been studied in our work. In order to test the influence of asymmetry of the primary immune organs, thymus, on the cellular immune response, mice were thymectomized and then we studied the effect of the injection of cells from contralateral thymus lobes of right-dominant and left-dominant donors by motor asymmetry on how pronounced the DTH reaction in the back left paw was. The injection of thymocytes from right-dominant donors appeared to result in significant differences in DTH reaction between left- and right-handed mice. At the same time, our experiments failed to discover any pronounced role of thymus asymmetry in the formation of DTH reaction. In order to test the influence of asymmetry of peripheral immune organs, regional lymph nodes, on the regulation of cellular immune response, we compared the DTH reaction in left and right paws of mice. We found that the intensity of the DTH reaction to sheep red blood cells in the front paws of (CBA x C57Bl/6) F1 mice depends not only on whether the antigen is injected into the left or right paw but also on the motor asymmetry of the hemispheres. While comparing the DTH reaction in the back left and right paw of mice we showed that in both right- and left-handed mice it was much more pronounced in the left paw than in the right one. The data obtained testify to the functional asymmetry of bilateral lymph nodes located near the forming cellular immune reaction. Thus, the results obtained show that the intensity of DTH reaction in (CBA x C57Bl/6) F1 mice depends on the functional asymmetry of regional lymph nodes and motor of brain hemispheres. The thymus functional asymmetry is of slight importance in DTH reaction.
Research Institute of Clinical Immunology, Siberian Branch of the Russian Academy of Medical Science, Novosibirsk-99, Russia.
Irina A
IA
Gontova
Valery V
VV
Abramov
Vladimir A
VA
Kozlov
D000818:Animals; D002490:Central Nervous System / Q000276:immunology* / Q000503:physiopathology; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000276:immunology; D005552:Forelimb / Q000276:immunology / Q000294:innervation; D007839:Functional Laterality / Q000502:physiology*; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000503:physiopathology; D007107:Immune System / Q000276:immunology* / Q000503:physiopathology; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009044:Motor Cortex / Q000276:immunology; D009068:Movement / Q000502:physiology; D015213:Neuroimmunomodulation / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology / Q000637:transplantation