Visual recovery after radiation therapy for bilateral subfoveal acute myelogenous leukemia (AML).
OBJECTIVE
Present a case of bilateral foveal acute myelogenous leukemic tumors that responded to radiation therapy.


METHODS
Case report.


METHODS
A patient was diagnosed with bilateral subfoveal infiltration of known systemic acute myelogenous leukemia. He received a standard induction chemotherapy, followed by consolidation therapy for his systemic leukemia. However, despite a complete marrow response, the intraocular tumors did not regress. Therefore, he was given low dose (1950-cGy) ocular external beam radiation therapy.


RESULTS
One course of systemic cytarabine chemotherapy failed to control the subfoveal tumors, leaving the patient at risk for permanent vision loss. In contrast, external beam radiation therapy improved his vision from 20/60 in his right eye to 20/20 and from 20/70 in his left eye to 20/25.


CONCLUSIONS
Although systemic chemotherapy can be used to treat intraocular metastasis, external beam radiation may provide more prompt resolution of vision-threatening tumors.
Finger
Paul T
PT
The Ocular Tumor Service, The New York Eye and Ear Infirmary, New York, New York 10021, USA. pfinger@eyecancer.com <pfinger@eyecancer.com>
Pro
Michael J
MJ
Schneider
Susan
S
Kurli
Madhavi
M
Shapira
Ilan
I
Hu
Kenneth
K
D000328:Adult; D005451:Fluorescein Angiography; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000503:physiopathology / Q000532:radiotherapy*; D008297:Male; D020127:Recovery of Function / Q000502:physiology*; D019572:Retinal Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D014792:Visual Acuity / Q000502:physiology*