Putative protective effect of inspiratory threshold loading against exercise-induced supraspinal diaphragm fatigue.
The present investigation was intended to assess the consequences of an inspiratory load on the diaphragm central component of fatigue during exercise. We recorded the motor potential evoked (MEP) by transcranial magnetic stimulation of the motor cortex in 10 subjects. The diaphragm and rectus femoris were studied before and 10, 20, and 40 min after two 16-min cycling exercise (E) trials requiring 55% of maximal oxygen uptake: 1) one with an inspiratory threshold load (E + ITL), corresponding to 10% of maximal inspiratory pressure; and 2) the other without the load (E). Dyspnea, heart rate, electromyographic activity of the sternocleidomastoid, and diaphragm work were significantly higher in E + ITL than in E. Neither trial affected the response to phrenic magnetic stimulation, which was performed 15 and 25 min postexercise, or the maximal inspiratory pressure (116 and 120 cm H(2)O before E and E + ITL, respectively, and 110 and 114 cm H(2)O at 30 min postexercise). Whereas the amplitude of the diaphragm MEP was unaffected by E + ITL (+2.1 +/- 29.4%), a significant decrease was observed 10 min after E compared with baseline (-37.1 +/- 22.3%) and compared with E + ITL. The MEP amplitude of rectus femoris remained unchanged with E and E + ITL. The recruitment of synergistic agonists during E + ITL may have normalized the major ventilatory stress and reset up the excitability of the diaphragm pathway.
Laboratoire des Adaptations Physiologiques aux Activités Physiques, UPRES EA 3813, Faculté des Sciences du Sport, 4 allée Jean Monnet, 86000 Poitiers, France. sophie.jonville@wanadoo.fr
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Jonville
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Jutand
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Similowski
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Denjean
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Delpech
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D003964:Diaphragm / Q000502:physiology*; D004056:Differential Threshold / Q000502:physiology*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D001239:Inhalation / Q000502:physiology*; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D018763:Muscle Fatigue / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*