Enhanced biocompatibility in biostable poly(carbonate)urethane.
In this work, we synthesized two MDI-based polyurethanes, including a poly(ether)urethane (PEU) and a poly(carbonate)urethane (PCU), by using different soft segments, poly(tetramethylene oxide) and poly(hexyl, ethyl)carbonate diol (M approximately 2,000). We demonstrated that, in addition to the enhanced biostability of PCU over PEU, the biological performances of PCU in vitro were also improved in general. These included, better cellular attachment and proliferation, less platelet activation, as well as reduced monocyte activation. The unusual wide-ranging enhancement in biocompatibility for PCU was believed to be related to the larger micro-phase separation in PCU (approximately 25 nm) that caused distinct protein adsorption on the surface. The total number of adherent monocytes (nonactivated and activated) on the bare sample surfaces, albumin pre-adsorbed sample surfaces, and fibrinogen pre-adsorbed sample surfaces.
Hsu
Shan-Hui
SH
Department of Chemical Engineering, National Chung Hsing University, Taichung, 402, Taiwan. shhsu@nchu.edu.tw
Kao
Yu-Chih
YC
Lin
Zu-Chang
ZC
D000327:Adsorption; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D005340:Fibrinogen; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry*; D012709:Serum Albumin; D013499:Surface Properties; D013816:Thermodynamics
D001672:Biocompatible Materials; D011108:Polymers; D011140:Polyurethanes; D012709:Serum Albumin; C110029:poly(carbonate urea) urethane; D005340:Fibrinogen