Mapping of a milk production quantitative trait locus to a 420-kb region on bovine chromosome 6.
A QTL affecting milk production traits was previously mapped to an interval of 7.5 cM on chromosome 6 in Norwegian dairy cattle. This article aimed to refine this position by increasing the map density in the region by a set of single-nucleotide polymorphisms and analyzing the data with a combined linkage and linkage disequilibrium approach. Through a series of single- and multitrait and single- and multipoint analyses, the QTL was positioned to an interval surrounded by the genes ABCG2 and LAP3. As no recombinations were detected in this interval, physical mapping was required for further refining. By using radiation hybrid mapping as well as BAC clones, the bovine and human comparative maps in the region are resolved, and the QTL is mapped within a distance of 420 kb.
Olsen
Hanne Gro
HG
Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N-1432 Aas, Norway.
Lien
Sigbjørn
S
Gautier
Mathieu
M
Nilsen
Heidi
H
Roseth
Arne
A
Berg
Paul R
PR
Sundsaasen
Kristil K
KK
Svendsen
Morten
M
Meuwissen
Theo H E
TH
D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D022202:Chromosomes, Artificial, Bacterial; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006239:Haplotypes; D007774:Lactation / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D009664:Norway; D040641:Quantitative Trait Loci / Q000235:genetics*