Reducing agents and Entamoeba histolytica.
Entamoeba histolytica remains an important but enigmatic parasite. It displays both non-pathogenic and invasive pathogenic types, which can be distinguished clinically and by isoenzyme markers. Yet as debated in Parasitology Today last year(1), the relationship between these two forms remains unclear. Bacterial associates and reducing agents are known to play on important role in the culture of E. histolytica, and possibly in its differentiation and invasive mechanisms. This article briefly reviews available information on the role o f reducing agents, and explores the possibility that bacteria may play a role in reduction o f toxic oxygen product - thereby promoting the virulence of E. histolytica. The review is not definitive, but should help to stimulate further research in this neglected area.
Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, India.
R K
RK
Mehlotra
O P
OP
Shukla