Optimization of sustained-release propranolol dosage form using factorial design and response surface methodology.
The purpose of this study was to develop propranolol extended release formulations containing hydroxypropylmethylcellulose (HPMC). The results indicate that the drug release from the tablet form containing a high amount of HPMC was incomplete, and avicel addition could increase the release percent at a later stage. In order to readily obtain an optimal formulation, response surface methodology and multiple response optimization utilizing a quadratic polynomial equation was used. The model formulations were prepared according to a factorial design. The effects of causal factors including the HPMC/drug ratio (X1) and avicel level (X2), on drug release were also measured. The drug release percentage at 1.5, 4, 8, 14 and 24 h were the target response and were restricted to not more than 25%, 35-50%, 55-70%, 75-90%, and 95-110%, respectively. The results showed that the optimized formulation provided a dissolution pattern equivalent to the predicted curve, which indicated that the optimal formulation could be obtained using response surface methodology. The mechanism of drug release from HMPC matrices tablets followed quasi-Fickian diffusion.
School of Pharmacy, Kaohsiung Medical University, Kaohsiung City, Taiwan.
Yaw-Bin
YB
Huang
Yi-Hung
YH
Tsai
Wan-Chiech
WC
Yang
Jui-Sheng
JS
Chang
Pao-Chu
PC
Wu
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000737:chemistry; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D008433:Mathematics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008954:Models, Biological; D011433:Propranolol / Q000008:administration & dosage* / Q000737:chemistry; D012044:Regression Analysis; D012995:Solubility; D013607:Tablets
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D013607:Tablets; D065347:Hypromellose Derivatives; D002482:Cellulose; D008747:Methylcellulose; D011433:Propranolol; C109691:microcrystalline cellulose