[Effects of interferonotherapy on functional activity of platelets in chronic viral hepatitis and cirrhosis of the liver].
OBJECTIVE
To characterize effects of interferon alpha (If-a) on functional activity of platelets in patients with chronic viral hepatitis (CVH) and viral hepatic cirrhosis (VHC).


METHODS
Induced platelet aggregation (PA), spontaneous PA, levels of cAMP, cGMP and glycogen in platelets, plasm beta-thromboglobulin (bTG) and activity of thrombocytic factor 4 (TF4) were measured in 95 patients before, 4.5 h after the first If-a introduction, after 12 and 24 weeks of If-a treatment.


RESULTS
The patients demonstrated low induced PA, intracellular glycogen and high cAMP, b-TG and TF4. The initial administration of If-a led to normalization of most of functional platelet indices. A 24-h course of If-a therapy normalized platelet functions irrespective of stability of the virusological response.


CONCLUSIONS
If-a preparations in single and multiple administrations normalize platelet function.
Iagoda
A V
AV
Koroĭ
P V
PV
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D002908:Chronic Disease; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism; D006152:Cyclic GMP / Q000032:analysis / Q000378:metabolism; D005260:Female; D006003:Glycogen / Q000032:analysis / Q000378:metabolism; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects
D016898:Interferon-alpha; D006003:Glycogen; D000242:Cyclic AMP; D006152:Cyclic GMP