Recombination mechanisms; fortieth anniversary meeting of the Holliday model.
The year 2004 marks the fortieth anniversary of the Holliday junction. This extraordinary DNA structure, originally proposed by Robin Holliday to explain genetic recombination in fungi, now appears to be a pivotal intermediate in many aspects of DNA metabolism. In those forty years the Holliday junction has gone from a hypothetical structure to models for its atomic structure and visualization of its dynamics at the single molecule level.
Heyer
Wolf-Dietrich
WD
Section of Microbiology, Center for Genetics and Development, University of California, Davis, CA 95616 USA. wdheyer@ucdavis.edu
Kanaar
Roland
R
D000818:Animals; D004249:DNA Damage / Q000502:physiology; D045566:DNA, Cruciform; D043211:Exodeoxyribonuclease V / Q000502:physiology; D005818:Genetic Engineering; D006801:Humans; D008957:Models, Genetic; D011995:Recombination, Genetic
D045566:DNA, Cruciform; D043211:Exodeoxyribonuclease V