Adsorption of cationic antibacterial on collagen-coated titanium implant devices.
Two different cationic antimicrobial molecules, chlorhexidine (CH) and poly(hexamethylenebiguanide) (PH), were adsorbed from aqueous solution to titanium implant devices surface-modified by the covalent coupling of collagen on a polyanionic acrylic acid overlayer. Results show that more antimicrobial was adsorbed on surface modified implants as compared to control titanium devices. Moreover, the kinetic of release was affected by the interaction between the polyanionic overlayer and the cationic antimicrobial, leading to slower kinetic of release in the case of CH and stable adsorption in the case of polycationic PH . These data indicate that biochemically modified collagen coated surfaces could be endowed also by antimicrobial properties, in the spirit of present researches on multifunctional implant surfaces.
Nobil Bio Richerche, Strada San Rocco, 32,Villafranca d'Asti, 14018, Italy. mmorra@tin.it
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M
Morra
C
C
Cassinelli
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G
Cascardo
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A
Carpi
M
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Fini
G
G
Giavaresi
R
R
Giardino
D000327:Adsorption / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000493:pharmacokinetics*; D002710:Chlorhexidine / Q000493:pharmacokinetics*; D003094:Collagen; D015918:Infusion Pumps, Implantable; D014025:Titanium / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D003094:Collagen; D014025:Titanium; D002710:Chlorhexidine