Multiple cerebral aneurysms and subarachnoid hemorrhage in a patient with Alagille syndrome.
Although intracranial hemorrhage has frequently been found responsible for mortality in adult patients with Alagille syndrome (AGS), no specific underlying cause has been identified. We describe the case of severe subarachnoid hemorrhage in a 30-year-old woman harboring five intracranial aneurysms and multiple peripheral vascular anomalies. To evaluate a possible higher incidence of intracranial aneurysms, a study of the cerebral vasculature in all AGS patients by using noninvasive imaging techniques should be considered.
Schlosser
Hans-Georg
HG
Department of Neurosurgery, Charité, Virchow-Clinic, Humboldt-University of Berlin, Berlin, Germany.
Kerner
Thoralf
T
Woiciechowsky
Christian
C
Benndorf
Goetz
G
D000328:Adult; D016738:Alagille Syndrome / Q000150:complications*; D000783:Aneurysm / Q000209:etiology; D001017:Aortic Coarctation / Q000209:etiology; D018376:Cardiovascular Abnormalities / Q000209:etiology; D002445:Celiac Artery; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000000981:diagnostic imaging* / Q000209:etiology*; D012077:Renal Artery; D012720:Severity of Illness Index; D013157:Splenic Artery; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging* / Q000209:etiology*