Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice.
Two inbred strains of mice, A/J, C57BL/6J and F2 intercross progenies,were used for QTL mapping for weight and cross-sectional area on cervical enlargement of spinal cord in mice. 13 QTLs located on Chromosome 2, 4, 8, 14, 15, 17, 18, 19 and X, respectively, for these two traits were found. Six QTLs were responsible for the cord weight, four for the cross-sectional area and three for both. Among 13 QTLs, three QTLs (P < 0.01) termed SC1 (located near D15Mit158) ,SC2 (DXMit140) and SC3 (DXMit64) accounted for 24%, 19% and 15% of the total variance in weight phenotype, and -3.78, 3.41 and 2.06 mg additive effect, respectively. The P value of other QTLs is between 0.01 and 0.05. SC1 is only one QTL that responsible for both weight and cross-sectional area in three QTLs above. This study revealed the location of major QTLs related size of spinal cord in mice, and may be helpful in fine mapping and ultimate identification of candidate genes.
Tan
Xiang-Ling
XL
Key Laboratory of Nerve Regeneration in Jiangsu Province, Nantong Medical College, Nantong 226001 China. tanxl@public.nt.js.cn
Zhou
Yan
Y
Cai
Ke-Fu
KF
Shao
Yi-Xiang
YX
Zhu
Shun-Xing
SX
Lu
L
L
Williams
R W
RW
Gu
Xiao-Song
XS
D000818:Animals; D002574:Cervical Vertebrae; D051379:Mice; D008810:Mice, Inbred C57BL; D018895:Microsatellite Repeats; D009929:Organ Size; D040641:Quantitative Trait Loci; D013116:Spinal Cord / Q000033:anatomy & histology* / Q000378:metabolism*