Effect of losartan versus atenolol on aortic valve sclerosis (a LIFE substudy).
Neither losartan- nor atenolol-based antihypertensive regimens could prevent the progression of aortic valve (AV) sclerosis in elderly, high-risk hypertensive patients, and the regression of AV sclerosis did not translate into reduced cardiovascular risk.
Olsen
Michael H
MH
Glostrup University Hospital, Glostrup, Denmark. mho@dadlnet.dk
Wachtell
Kristian
K
Bella
Jonathan N
JN
Liu
Jennifer E
JE
Boman
Kurt
K
Gerdts
Eva
E
Papademetriou
Vasilios
V
Nieminen
Markku S
MS
Rokkedal
Jens
J
Dahlöf
Björn
B
Devereux
Richard B
RB
D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000473:pathology* / Q000503:physiopathology; D001262:Atenolol / Q000627:therapeutic use*; D005260:Female; D006349:Heart Valve Diseases / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012598:Sclerosis
D001262:Atenolol; D019808:Losartan