Immunopathology of granuloma formation and fibrosis in schistosomiasis.
In schistosomiasis the deposition of parasite ova within host tissues is the initial event in a complex pathophysiological cascade which is characterized by granuloma formation, and may terminate in fibrosis and related sequelae (Fig. 1). In spite of intensive study, the complex relationship between infection and morbidity remains poorly understood. In this article, Michael Phillips and Patrick Lammie review current concepts of the mechanisms of granuloma formation and its regulation in schistosome infections.
Phillips
S M
SM
University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Lammie
P J
PJ