Tubulin as a regulator of G-protein signaling.
Tubulin is known to form high-affinity complexes with certain G proteins. The formation of such complexes allows tubulin to activate Galpha and fosters a system whereby elements of the cytoskeleton can influence G-protein signaling. This article describes the interaction between tubulin and G proteins and discusses methods for examining this interaction.
Department of Physiology & Biophysics, University of Illinois, Chicago 60612, USA.
Mark M
MM
Rasenick
Robert J
RJ
Donati
Juliana S
JS
Popova
Jiang-Zhou
JZ
Yu
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D004789:Enzyme Activation; D044385:GTP-Binding Protein alpha Subunits / Q000235:genetics / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D054799:Phospholipase C beta; D011485:Protein Binding; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*; D014404:Tubulin / Q000378:metabolism*; D010738:Type C Phospholipases / Q000378:metabolism
D044385:GTP-Binding Protein alpha Subunits; D007527:Isoenzymes; D011993:Recombinant Fusion Proteins; D014404:Tubulin; D006160:Guanosine Triphosphate; D010738:Type C Phospholipases; D054799:Phospholipase C beta; D019204:GTP-Binding Proteins