Stoichiometric and catalytic reductive aldol cyclizations of alkynediones induced by Stryker's reagent.
Conjugate reduction of alkynones by stoichiometric [(Ph(3)P)CuH](6) or catalytic [(Ph(3)P)CuH](6) and polymethyl-hydrosiloxane proceeds to cyclization by an aldol reaction with tethered ketones to generate [small beta]-hydroxyenones with good diastereoselectivity.
Chiu
Pauline
P
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. pchiu@hku.hk.
Leung
Sze Kar
SK