Candidate protein selection for diagnostic markers of African trypanosomiasis.
The ability to accurately diagnose the presence of an infective micro-organism is not only important for individual human and animal health and wellbeing, but is also central to surveillance programmes. Effective and sustainable control of many diseases in the developing world depends on the availability of field applicable diagnostics that are cheap, reliable, simple in design and application, and which provide immediate results. This review examines how the genome sequences can be used in the selection of potential candidate proteins for developing new serodiagnostics for African trypanosomiasis.
Institute of Zoology, Zoological Society of London, Regent's Park, London, NW1 4RY, UK.
Oliver Clyde
OC
Hutchinson
Helena
H
Webb
Kim
K
Picozzi
Sue
S
Welburn
Mark
M
Carrington
D000818:Animals; D015415:Biomarkers / Q000097:blood; D018503:Genome, Protozoan; D006801:Humans; D015800:Protozoan Proteins; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D013045:Species Specificity; D013997:Time Factors; D014347:Trypanosoma brucei gambiense / Q000235:genetics / Q000302:isolation & purification*; D014353:Trypanosomiasis, African / Q000175:diagnosis*
D015415:Biomarkers; D015800:Protozoan Proteins