Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan.
Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (C270T named formerly) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C > T in exon V: genotype, P = 0.586, allele, P = 0.594; 196G > A (val66met) in exon XIIIA: genotype, P = 0.889, allele, P = 0.713). Furthermore, there was no difference between clinical parameters (e.g., prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C > T in exon V and 196G > A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers. This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html.
Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan.
Kanako
K
Itoh
Kenji
K
Hashimoto
Eiji
E
Shimizu
Yoshimoto
Y
Sekine
Norio
N
Ozaki
Toshiya
T
Inada
Mutsuo
M
Harano
Nakao
N
Iwata
Tokutaro
T
Komiyama
Mitsuhiko
M
Yamada
Ichiro
I
Sora
Kenji
K
Nakata
Hiroshi
H
Ujike
Masaomi
M
Iyo
D000328:Adult; D000483:Alleles; D019969:Amphetamine-Related Disorders / Q000209:etiology / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008694:Methamphetamine / Q000506:poisoning; D008875:Middle Aged; D011110:Polymorphism, Genetic
D019208:Brain-Derived Neurotrophic Factor; D008694:Methamphetamine