[Effects of immunomodulating therapy on immune status and the disease course in patients with relapsing herpetic stomatitis].
Clinical and immunological efficiency of leukinferone in combination with polyoxidonium (immunomodulator) was studied in patients with relapsing herpetic stomatitis (RHS). The levels of alpha- and gamma-IFN were decreased, levels of IgM, IgG, and IgE were increased, active oxygen forms were actively produced, and the count of CD8(+)-cells was increased in patients with RHS. Treatment with polyoxidonium and leukinferone led to an increase of the blood levels of alpha- and gamma-IFN, decrease of IgM, IgG, and IgE levels, normalization of phagocytosis, and decrease of CD8(+)-cell count. The treatment had a pronounced clinical effect in patients with RHS of any severity, which indicates the efficiency of these drugs in combined therapy of patients with RHS.
O F
OF
Rabinovich
I M
IM
Rabinovich
B V
BV
Pinegin
N V
NV
Razzhivina
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D016827:CD8 Antigens / Q000097:blood; D016207:Cytokines / Q000494:pharmacology / Q000627:therapeutic use*; D004338:Drug Combinations; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007136:Immunoglobulins / Q000097:blood; D007370:Interferon Type I / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009930:Organic Chemicals; D010587:Phagocytosis / Q000187:drug effects; D055502:Secondary Prevention; D013283:Stomatitis, Herpetic / Q000097:blood / Q000188:drug therapy* / Q000276:immunology*; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D016827:CD8 Antigens; D016207:Cytokines; D004338:Drug Combinations; D007136:Immunoglobulins; D007370:Interferon Type I; D009930:Organic Chemicals; C062252:leukinferon; C089921:polyoxydonium