A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects.
Mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the 150T polymorphism in the noncoding region, have been associated with longevity. We have studied here the association of 150T with longevity further and assessed differences in this association between various mtDNA haplogroups. We analysed a sample of 321 very old subjects and 489 middle-aged controls from Finland and Japan. 150T was more frequent among the very old than among the controls in both the Finnish and Japanese subjects. Interestingly, the association was not similar in all haplogroups, and a stratified analysis revealed that two additional common polymorphisms, 489C and 10398G, modified the association between 150T and longevity. These findings suggest that longevity is partly determined by epistatic interactions involving these three mtDNA loci.
Department of Neurology, University of Oulu, FIN-90014 Oulu, Finland.
Anna-Kaisa
AK
Niemi
Jukka S
JS
Moilanen
Masashi
M
Tanaka
Antti
A
Hervonen
Mikko
M
Hurme
Terho
T
Lehtimäki
Yasumichi
Y
Arai
Nobuyoshi
N
Hirose
Kari
K
Majamaa
D000368:Aged; D000369:Aged, 80 and over; D004272:DNA, Mitochondrial / Q000235:genetics*; D004843:Epistasis, Genetic; D005260:Female; D005387:Finland; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007564:Japan; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics
D004272:DNA, Mitochondrial