Short-term vasomotor adjustments to post immersion dehydration are hindered by natriuretic peptides.
Many studies have described the physiology of water immersion (WI), whereas few have focused on post WI physiology, which faces the global water loss of the large WI diuresis. Therefore, we compared hemodynamics and vasomotor tone in 10 trained supine divers before and after two 6h sessions in dry (DY) and head out WI environments. During each exposure (DY and WI) two exercise periods (each one hour 75W ergometer cycling) started after the 3rd and 5th hours. Weight losses were significant (-2.24 +/- 0.13 kg and -2.38 +/- 0.19 kg, after DY and WI, respectively), but not different between the two conditions. Plasma volume was reduced at the end of the two conditions (-9.7 +/- 1.6% and -14.7 +/- 1.6%, respectively; p < 0.05). This post-WI decrease was deeper than post DY (p < 0.05). Cardiac output (CO) and mean arterial blood pressure were maintained after the two exposures. Plasma levels of noradrenaline, antidiuretic hormone and ANP were twofold higher after WI than after DY (p < 0.05). After DY total peripheral resistances (TPR) were increased (p < 0.05) and heart rate (HR) was reduced (p < 0.05). After WI there was a trend for a decrease in stroke volume (p = 0.07) with unchanged TPR and HR, despite more sizeable increases in plasma noradrenaline and vasopressin than after DY. We hypothesized that the higher levels of plasma natriuretic peptides after WI were likely counteracting the dehydration-required vasomotor adjustments.
Physiologie Médecine and EA 479, Faculté de Médecine et de Pharmacie, Place St Jacques 25030 Besançon, France.
L
L
Mourot
J P
JP
Wolf
F
F
Galland
C
C
Robinet
A
A
Courtière
M
M
Bouhaddi
J L
JL
Meliet
J
J
Regnard
D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology; D003681:Dehydration / Q000097:blood / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007101:Immersion / Q000503:physiopathology*; D008297:Male; D045265:Natriuretic Peptides / Q000097:blood*; D010953:Plasma Volume / Q000502:physiology; D018709:Statistics, Nonparametric; D013997:Time Factors; D014666:Vasomotor System / Q000502:physiology
D045265:Natriuretic Peptides