[The effect of propofol on isolated human pregnant uterine muscles].
OBJECTIVE
To investigate the effects of propofol on spontaneous contractions of isolated human pregnant myometrial smooth muscles.


METHODS
Twenty isolated human pregnant myometrial muscle strips with rhythmic spontaneous contraction were randomly divided into two groups: control group (n=10) and propofol group (n=10). In propofol group propofol was added cumulatively. The changes of uterine contraction were monitored.


RESULTS
Propofol at concentration of 0. 5 microg/ml and 2 microg/ml had no effect on the spontaneous contraction of isolated human pregnant uterine muscles; propofol at concentration of 5 microg/ml and 10 microg/ml could significantly reduce the spontaneous contraction of isolated human pregnant uterine muscles; the higher the concentration was, the more would be the reduction. The effect could be blocked by oxytocin (140 +/- 50) microU/ml.


CONCLUSIONS
Propofol could significantly reduce the spontaneous rhythmic contractions of isolated human pregnant myometrial smooth muscles in concentration-dependent manner. Oxytocin could antagonize the action.
Luo
Dong
D
Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, China.
Wang
Quan-yun
QY
Huang
Wei
W
Lü
Sheng
S
Kong
Gu-ya
GY
D000328:Adult; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009215:Myometrium / Q000502:physiology; D011247:Pregnancy; D015742:Propofol / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D015742:Propofol