Post-transcriptional gene silencing in neurons.
The techniques evolving from the rapidly developing field of small RNAs promise accessible approaches to dissecting cellular and molecular mechanisms of higher brain function. Here, a current overview of the technology is presented, along with an outline of how these approaches might help neuroscientists to more rapidly uncover the cellular and molecular bases of behavior.
Zeringue
Henry C
HC
Department of Biology, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Constantine-Paton
Martha
M
D000818:Animals; D001921:Brain / Q000502:physiology*; D018390:Gene Targeting / Q000379:methods / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D023421:Models, Animal; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D009474:Neurons / Q000502:physiology*; D034622:RNA Interference / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics*
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering