Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV.
Inhibition of phagolysosome biogenesis in infected macrophages is a classical pathogenesis determinant of Mycobacterium tuberculosis. In this review we primarily cover the cellular mechanisms of M. tuberculosis phagosome maturation arrest. A detailed picture is beginning to emerge, involving regulators of membrane trafficking in mammalian cells and phagosomal interactions with endosomal organelles and the trans-Golgi network. We also present a hypothesis that overlaps may exist between the mycobacterial interference with the host cell membrane trafficking processes and the targeting of the late endosomal sorting machinery by HIV during viral budding in macrophages. We propose that interference with the endosomal sorting machinery contributes to the synergism between the two significant human diseases--AIDS and tuberculosis.
Department of Molecular Genetics, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131-001, USA. vderetic@salud.unm.edu
Vojo
V
Deretic
Isabelle
I
Vergne
Jennifer
J
Chua
Sharon
S
Master
Sudha B
SB
Singh
Joseph A
JA
Fazio
George
G
Kyei
D002462:Cell Membrane / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism*; D005786:Gene Expression Regulation; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008264:Macrophages / Q000382:microbiology / Q000648:ultrastructure / Q000821:virology; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D010587:Phagocytosis