[Molecular pharmacogenetic studies of drug responses to obsessive-compulsive disorder and six functional genes].
OBJECTIVE
To investigate the associations between the drug responses to obsessive -pulsive disorder (OCD) and six functional genes related with serotonin and dopamine.


METHODS
One hundred and thirteen OCD nuclear families were collected. The OCD patients were treated with serotonin reuptake inhibitors (SRIs) for 8 weeks and the drug responses were assessed using the Yale-Brown obsessive-compulsive scale (Y-BOCS). The patients were divided into drug responders group and non-responders group according to the reducing rate of Y-BOCS score. The genotypes of six genes were determined with the Amp-FLP and Amp-RFLP techniques and analyzed by transmission disequilibrium test (TDT). The six genes are serotonin 2A receptor (5-HT2A), serotonin transporter (5-HTT), dopamine D2 receptor ( DRD2), dopamine D4 receptor (DRD4), catechol-O- methyltransferase (COMT) and monoamine oxidase A (MAOA).


RESULTS
No association was found between the six genes and different drug responses groups. However, there was significant difference between the drug responders and non-responders in homozygosity at the 5-HT2A -1438G/A locus (chi(2)=4.69, P=0.03).


CONCLUSIONS
The results suggested that the 5-HT2A may play some roles in the effects of drug treatment on OCD.
Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P.R. China. zhanglan@mail.sc.cninfo.net
Lan
L
Zhang
Xiehe
X
Liu
Tao
T
Li
Yanchun
Y
Yang
Xun
X
Hu
David
D
Collier
D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics / Q000379:methods; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050638:Receptors, Dopamine D4 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
D002394:Catechol O-Methyltransferase; D008995:Monoamine Oxidase; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; C493230:SLC6A4 protein, human