The use of antisense oligonucleotides as chemotherapeutic agents for parasites.
Although several approaches to the control of human parasites are possible, the prevention and therapy of the corresponding diseases still remain a difficult task. The development of vaccines has been hampered by the poor immunological response to or the high variability of parasitic antigens. Problems also arise for chemotherapy where differences in the biochemistry of host and parasite must be exploited. The increasingly difficult search for new drugs is always challenged by the appearance of resistance.
Sartorius
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Biocenter, Department of Structural Biology, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Franklin
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RM