Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi.
From the whole plant of Dracocephalum kotschyi BOISS., two new monoterpene glycosides (9, 10), together with seven known terpenoids and a phytosterol (1-8), were isolated. Their structures were determined to be limonen-10-al (1), geranial (2), neral (3), beta-sitosterol (4), oleanolic acid (5), ursolic acid (6), p-mentha-8-en-1,2-diol (7), colosolic acid (8), limonen-10-ol 10-O-beta-D-glucopyranoside (9), and limonen-10-ol 10-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (10). Compounds 1 (3.1 microM), 2 (3.1 microM), 3 (3.1 microM), 5 (6.2 microM), 6 (6.2 microM), and 8 (6.2 microM) were effective against epimastigotes of Trypanosoma cruzi.
Department of Pharmacy, Faculty of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran.
Soodabeh
S
Saeidnia
Ahmad Reza
AR
Gohari
Nahoko
N
Uchiyama
Michiho
M
Ito
Gisho
G
Honda
Fumiyuki
F
Kiuchi
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019686:Lamiaceae; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D039821:Monoterpenes; D013729:Terpenes; D014344:Trypanocidal Agents