Use of polyurethane with sustained release dexamethasone in delayed adjustable strabismus surgery.
OBJECTIVE
To determine the effect of polyurethane film with sustained release dexamethasone (SRD) in delayed adjustable strabismus surgery.


METHODS
A prospective, masked observer, controlled study was performed in rabbits. Thirty four rabbit eyes were divided into three groups. After recession of the superior rectus muscle (SRM), polyurethane film with or without SRD, or balanced salt solution was applied beneath and over SRM in the polyurethane-dexamethasone group (group P-D), polyurethane group (group P), and the control group (group C), respectively. Delayed adjustment was performed once on each SRM at 4 and 6 weeks postoperatively by a masked observer. The possible length to adjust and the necessary force required for the adjustment, as well as the degree of any adhesions, were also evaluated.


RESULTS
In the control group, adjustment was impossible in all of the eyes at 4 and 6 weeks postoperatively. In group P-D, adjustment was possible in 11 out of 11 eyes (11/11) 4 weeks postoperatively and in 10/11 eyes 6 weeks postoperatively. In group P, adjustment was possible in 9/11 eyes 4 weeks postoperatively and in 10/12 eyes 6 weeks postoperatively.


CONCLUSIONS
Use of polyurethane film with and without SRD could delay adjustment in most eyes for up to 6 weeks postoperatively. Polyurethane is helpful for delaying adjustment in rabbit eyes until 6 weeks postoperatively without the need for frequent topical instillation of steroids.
Department of Ophthalmology, College of Medicine Seoul National University, Seoul National University Bundang Hospital, Seongnam, Korea.
J H
JH
Kim
S Y
SY
Jeong
M H
MH
Jung
J-M
JM
Hwang
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003229:Conjunctival Diseases / Q000517:prevention & control; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage*; D009801:Oculomotor Muscles / Q000473:pathology; D011140:Polyurethanes / Q000008:administration & dosage*; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011817:Rabbits; D015422:Scleral Diseases / Q000517:prevention & control; D013285:Strabismus / Q000473:pathology / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control
D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D011140:Polyurethanes; D003907:Dexamethasone