Ondansetron amelioration of scopolamine induced cognitive deficits in three-panel runway apparatus in rats.
Effect of ondansetron (5-HT3-receptor antagonist) was studied on the working memory deficits induced by scopolamine, a muscarinic receptor antagonist in rats using a three-panel runway apparatus. Varying doses of scopolamine (0.1-0.56mg/kg, ip) were administered alone or in combination with ondansetron (0.01-1.0 mg/kg, ip) and memory errors and latency period of the session were recorded on a three-panel runway apparatus. Treatment with scopolamine (0.56 mg/kg) produced working memory deficits in rats. Treatment with ondansetron (1.0 mg/kg) significantly reduced the scopolamine-induced working memory deficits.
Department of Pharmacology, Lady Hardinge Medical College, New Delhi 110001, India. nk999999@rediffmail.com
Naveen
N
Kumar
Anil Kumar
AK
Kela
D000818:Animals; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D018727:Muscarinic Antagonists / Q000633:toxicity*; D017294:Ondansetron / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000633:toxicity*; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D018727:Muscarinic Antagonists; D012702:Serotonin Antagonists; D017294:Ondansetron; D012601:Scopolamine