Prevalence of anti-heat shock protein antibodies in cerebrospinal fluids of patients with Guillain-Barré syndrome.
We examined antibodies against 10 heat shock proteins (HSPs) in cerebrospinal fluids (CSF) and sera from patients with Guillain-Barré syndrome (GBS). Significantly higher IgG antibody titers against HSP27, HSP60, HSP70 and HSP90 family, including mycobacterial HSP65 and Escherichia coli GroEL, were found in CSF from GBS patients as compared with motor neuron disease. Serum IgG antibodies against each HSP showed no difference between GBS patients and normal controls. GBS seems to be induced by reactive autoimmune responses frequently triggered by infections. The CSF antibodies against HSPs may modify the immune responses and/or cell-protective functions of HSPs in the pathophysiology of GBS.
Department of Neurology, Sapporo Medical University School of Medicine, Minami 1-Jo Nishi 16 chome, Chuo-ku, Sapporo 060-8543, Japan.
Kazumi
K
Yonekura
Shin-ichi
S
Yokota
Shingo
S
Tanaka
Hiroshi
H
Kubota
Nobuhiro
N
Fujii
Hiroyuki
H
Matsumoto
Susumu
S
Chiba
D000328:Adult; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid* / Q000453:epidemiology / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000134:cerebrospinal fluid* / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
D001323:Autoantibodies; D006360:Heat-Shock Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M