[Impact of cardiopulmonary bypass on free amino acid spectrum in plasma for patients with prosthetic valve replacement during the perioperative period].
OBJECTIVE
To investigate the impact of cardiopulmonary bypass (CPB) on free amino acid spectrum in plasma for patients with prosthetic valve replacement.


METHODS
The concentrations of the free amino acid in plasma for 22 patients with prosthetic valve replacement were measured with pre-column derivatization of high-performance liquid chromatography.


RESULTS
Compared with the preoperative data, the concentrations of some free amino acid in plasma decreased after the operation of cardiopulmonary bypass (CPB), especially some of the glucogenic amino acid and branch chain amino acid decreased significantly (P<0.05).


CONCLUSIONS
The operation of cardiopulmonary bypass (CPB) can decrease the concentrations of some free amino acid in plasma for patients with prosthetic valve replacement. It is essential to give these patients proper nutrition support during perioperative period.
Nie
Liang-ming
LM
Department of Thoracic Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiao
Xi-jun
XJ
Liang
Mao-zhi
MZ
Liu
Guan-jian
GJ
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D001021:Aortic Valve / Q000601:surgery; D002315:Cardiopulmonary Bypass; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood* / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D018529:Nutritional Support / Q000379:methods; D011184:Postoperative Period
D000596:Amino Acids