[Signal transduction on transdifferentiation of renal tubular epithelial cell].
It is an important cell biological phenomenon that epithelial cells transit into mesenchymal cells under special physiological and pathological condition. In recent years, it has been known that epithelial-mesenchymal-transition may be mediated by several intracellular signaling pathways, such as MAPK, Rho, Src, PI3 kinase and Smads. Renal tubular epithelial cells have been observed to transit to myo-fibroblasts in renal diseases. However, the intracellular signaling pathways are rarely known. The progress on this field is reviewed.
Renal Division, Department of Medicine, First Hospital and Institute of Nephrology, Peking University, Beijing 100034.
Mei
M
Zhang
Xiao-Mei
XM
Li
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D006801:Humans; D007684:Kidney Tubules / Q000166:cytology* / Q000254:growth & development; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D009395:Nephritis, Interstitial / Q000473:pathology; D015398:Signal Transduction
D020928:Mitogen-Activated Protein Kinases