[Signal transduction on transdifferentiation of renal tubular epithelial cell].
It is an important cell biological phenomenon that epithelial cells transit into mesenchymal cells under special physiological and pathological condition. In recent years, it has been known that epithelial-mesenchymal-transition may be mediated by several intracellular signaling pathways, such as MAPK, Rho, Src, PI3 kinase and Smads. Renal tubular epithelial cells have been observed to transit to myo-fibroblasts in renal diseases. However, the intracellular signaling pathways are rarely known. The progress on this field is reviewed.
Zhang
Mei
M
Renal Division, Department of Medicine, First Hospital and Institute of Nephrology, Peking University, Beijing 100034.
Li
Xiao-Mei
XM
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D006801:Humans; D007684:Kidney Tubules / Q000166:cytology* / Q000254:growth & development; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D009395:Nephritis, Interstitial / Q000473:pathology; D015398:Signal Transduction
D020928:Mitogen-Activated Protein Kinases