Mortality analysis of HIV-1 infected patients for prioritizing antiretroviral drug therapy.
Mortality data of patients, classified according to their clinical status and CD4+ cell count status, would be very useful to guide clinicians to prioritizing patients who need antiretroviral drug therapy. In the current study, the authors re-analyzed data derived from a previously published retrospective study of HIV-1-infected individuals at Lampang Hospital in northern Thailand. According to the Cox proportional hazard model, compared to asymptomatic patients with a high CD4+ cell count (> 200 cell/microl), the mortality rate of asymptomatic patients with a medium CD4+ cell count (100-199 cell/microl) did not significantly differ. However, the mortality rate of patients with a CD4+ cell count below 100 cell/microl was at least 16 times higher, regardless of the presence of clinical symptoms. Based on these results, the authors produced a Lampang Hospital guideline of antiretroviral drug use; priority of antiretroviral therapy should, therefore, be given to patients with CD4+ cell count < 100 cell/microl.
Lampang Hospital, Ampur Muang Lampang, Thailand.
Panita
P
Pathipvanich
Archawin
A
Rojanawiwat
Koya
K
Ariyoshi
Toshiyuki
T
Miura
Wadchara
W
Pumpradit
Suchint
S
Wongchoosie
Pipat
P
Yingseree
Paijit
P
Warachit
Pathom
P
Sawanpanyalert
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality*; D015497:HIV-1; D006801:Humans; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors
D019380:Anti-HIV Agents