Autologous human fibrin as the biomaterial for tissue engineering.
Patient own fibrin may act as the safest, cheapest and immediate available biodegradable scaffold material in clinical 1 tissue engineering. This study investigated the feasibility of using patient own fibrin isolated from whole blood to construct a new human cartilage, skin and bone. Constructed in vitro tissues were implanted on the dorsal part of the nude mice for in vivo maturation. After 8 weeks of implantation, the engineered tissues were removed for histological analysis. Our results demonstrated autologous fibrin has great potential as clinical scaffold material to construct various human tissues.
Department of Physiology, Medical Faculty of Universiti Kebangsaan Malaysia.
B H I
BH
Ruszymah
D000818:Animals; D001672:Biocompatible Materials; D016025:Bone Transplantation; D002356:Cartilage / Q000637:transplantation*; D002455:Cell Division / Q000502:physiology; D003470:Culture Media; D005337:Fibrin; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051379:Mice; D008819:Mice, Nude; D009924:Organ Culture Techniques; D010521:Periosteum / Q000166:cytology; D016038:Skin Transplantation; D023822:Tissue Engineering
D001672:Biocompatible Materials; D003470:Culture Media; D005337:Fibrin