Adenomyosis in the baboon is associated with primary infertility.
OBJECTIVE
To determine whether an association exists between the histopathologic diagnosis of adenomyosis and infertility in a population of captive baboons.


METHODS
Case-control study.


METHODS
Southwest National Primate Research Center.


METHODS
Necropsy records of 37 baboons diagnosed with adenomyosis uteri and 38 baboons with normal uterine histology.


METHODS
None.


METHODS
Chi2 analysis of the association between adenomyosis, primary infertility, and the presence of coexisting endometriosis.


RESULTS
Endometriosis was associated with the presence of adenomyosis (OR = 31.5, 95% CI 4.2-1,348). There was a trend toward an association of endometriosis with the presence of lifelong infertility, but this correlation did not quite achieve statistical significance (OR = 3.6, 95% CI 0.9-15.8). Adenomyosis was associated with the presence of lifelong infertility (OR = 20.6, 95% CI 2.7-897). This association was maintained when cases of coexisting endometriosis (n = 17) were excluded (OR = 20.1, 95% CI 2.1-921).


CONCLUSIONS
Adenomyosis is strongly associated with lifelong primary infertility in the baboon, even in the absence of coexisting endometriosis.
Barrier
Breton F
BF
Southwest Foundation for Biomedical Research, San Antonio, Texas, USA. reton.barrier@lackland.af.mil
Malinowski
Marshall J
MJ
Dick
Edward J
EJ
Hubbard
Gene B
GB
Bates
G Wright
GW
D000818:Animals; D002908:Chronic Disease; D016001:Confidence Intervals; D004715:Endometriosis / Q000150:complications* / Q000473:pathology; D005260:Female; D007247:Infertility, Female / Q000209:etiology*; D016017:Odds Ratio; D010215:Papio