Synthesis and fungicidal activity of ethaboxam against Oomycetes.
This study describes the chemical synthesis and intrinsic fungicidal activity of ethaboxam [(RS)-N-(alpha-cyano-2-thenyl)-4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide], a new Oomycetes fungicide. In in vitro tests, ethaboxam showed inhibitory activity against isolates of Phytophthora and some Pythium spp, with MIC values ranging from 0.1 to 0.5 mg litre(-1) for nine isolates of Phytophthora infestans (Montagne) de Bary and from 1.0 to 5.0 mg litre(-1) for eight isolates of Phytophthora capsici Leonian. In tests to determine time and concentration for complete inactivation of each pathogen (five isolates of P infestans and five isolates of P capsici), ethaboxam inactivated all isolates of P infestans within 48h at 10 mg litre(-1) and those of P capsici within 96 h at 10 mg litre(-1). Ethaboxam effectively suppressed development of tomato late blight caused by P infestans and pepper Phytophthora blight caused by P capsici in the studies conducted to determine its preventive, curative, persistent and systemic activity. These results show that ethaboxam has desirable fungicidal characteristics as an Oomycetes fungicide.
Kim
Dal-Soo
DS
LG Life Sciences Ltd, R&D Park, 104-1, Moonjidong, Yuseonggu, Daejeon 305-380, Korea. dalskim@lgls.co.kr
Chun
Sam-Jae
SJ
Jeon
Jae-Jin
JJ
Lee
Sang-Who
SW
Joe
Goon-Ho
GH
D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D009868:Oomycetes / Q000187:drug effects* / Q000254:growth & development; D010838:Phytophthora / Q000187:drug effects / Q000254:growth & development; D010935:Plant Diseases / Q000382:microbiology*; D011775:Pythium / Q000187:drug effects / Q000254:growth & development; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*
D005659:Fungicides, Industrial; D013844:Thiazoles; D013876:Thiophenes; C492076:ethaboxam