Novel applications of therapeutic hypothermia: report of three cases.
Therapeutic hypothermia can provide neuroprotection in various situations where global or focal neurological injury has occurred. Hypothermia has been shown to be effective in a large number of animal experiments. In clinical trials, hypothermia has been used in patients with postanoxic injury following cardiopulmonary resuscitation, in traumatic brain injury with high intracranial pressure, in the perioperative setting during various surgical procedures and for various other indications. There is thus evidence that hypothermia can be effective in various situations of neurological injury, although a number of questions remain unanswered. We describe three patients with unusual causes of neurological injury, whose clinical situation was in fundamental aspects analogous to conditions where hypothermia has been shown to be effective.
Department of Intensive Care and Surgery, VU University Medical Center, Amsterdam, The Netherlands. kjhartemink@hetnet.nl <kjhartemink@hetnet.nl>
Koen J
KJ
Hartemink
Willem
W
Wisselink
Jan A
JA
Rauwerda
Armand R J
AR
Girbes
Kees H
KH
Polderman
D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D002560:Cerebrovascular Circulation; D003422:Critical Care / Q000379:methods*; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000628:therapy; D012151:Resuscitation / Q000379:methods; D016896:Treatment Outcome