Disposition of 4,6,4'-trimethylangelicin in mice maintained in the dark and after UVA irradiation.
The disposition of the furocoumarin 4,6,4'-trimethylangelicin (4,6,4'-TMA) was studied in mice. After oral administration of (3)H 4,6,4'-TMA, radioactivity measured in serum shows fast absorption and slow elimination. Serum protein binding is higher as compared to 8-methoxypsoralen (8-MOP), currently used in photochemotherapy (PUVA) and linearly declines from 30 min to 6 h after administration. Distribution in the various organs was similar to that of 8-MOP and was relatively uninfluenced by UVA radiation, required for the biological effects of 4,6,4'-TMA. Mice eliminate (3)H 4,6,4'-TMA mostly through the urine, but also through the faeces. Two metabolites were identified in the urine and serum of the treated mice, one of which proved to be a derivative of 4,6,4'-TMA, formed by hydrogenation of the double 4',5' bond of the furocoumarin nucleus.
Bevilacqua
R
R
Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, I-35131 Padua, Italy. rita.bevilacqua@unipd.it
Baccichetti
F
F
Gaion
R M
RM
Guiotto
A
A
D000818:Animals; D003624:Darkness; D011564:Furocoumarins / Q000493:pharmacokinetics*; D051379:Mice; D011701:PUVA Therapy; D011485:Protein Binding; D014018:Tissue Distribution; D014466:Ultraviolet Rays
D011564:Furocoumarins; C041621:4,4',6-trimethylangelicin