[Adrenoleukodystrophy: single voxel MR spectroscopy findings (case report)].
Adrenoleukodystrophy is a rare genetic disorder. Histopathological features of this disorder include demyelination and axonal loss in white matter. We describe a six-year-old boy with significantly decreased N-acetyl-aspartate (NAA)/Creatin (Cr), increased Choline (Cho)/Cr and Myo-inositol (MI)/Cr in parieto-occipital white matter by MR spectroscopy. In contrast to the normal appearance of frontal white matter on MR imaging, increased Cho/Cr and MI/Cr ratios were detected on MR spectroscopy. These changes in involved areas could be an indication of neuroaxonal loss, demyelination and gliosis.
Alkan
Alpay
A
Inönü Universitesi Tip Fakültesi, Turgut Ozal Tip Merkezi, Radyodiagnostik Anabilim Dali, Malatya, Turkey.
Kutlu
Ramazan
R
Aslan
Mehmet
M
Yakinci
Cengiz
C
D000326:Adrenoleukodystrophy / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male