Untangling the web: mitochondrial fission and apoptosis.
Mitochondria exist as an interconnected network that is constantly remodeled by balancing membrane fission and fusion events. A new study by Szabadkai et al. in the October 8th issue of Molecular Cell shows that dynamin-related protein 1 (Drp1)-induced scission hinders the ability of mitochondria to transport calcium across the cell and mediate apoptosis.
Oakes
Scott A
SA
Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA.
Korsmeyer
Stanley J
SJ
D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002118:Calcium / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002462:Cell Membrane / Q000378:metabolism; D064550:Death-Associated Protein Kinases; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D064550:Death-Associated Protein Kinases; D017346:Protein Serine-Threonine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002118:Calcium