Effect of cefoxitin and clindamycin on selection of derepressed mutants in Enterobacter cloacae.
The characteristics of an antibiotic that favor its ability to select for resistant bacteria are not completely understood. Otherwise, by the common use of broad-spectrum cephalosporins, resistant strains of several gram-negative species, especially Enterobacter cloacae, have been more frequently isolated. During our studies on beta-lactam resistance in E. cloacae, we observed that the addition of an inhibitor (clindamycin) to a potent inducer (cefoxitin) leads to an enhanced selection of resistant mutants. This could explain the emergence of beta-lactam resistant strains during antibiotic therapy.
Department of Experimental Medicine, Section of Human Anatomy, University of Genova, Italy.
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D
Saverino
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Milintenda-Floriani
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Medeiros
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D015964:Gene Expression Regulation, Bacterial; D008826:Microbial Sensitivity Tests; D009154:Mutation; D012641:Selection, Genetic; D018440:beta-Lactam Resistance / Q000235:genetics
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D002440:Cefoxitin; D002439:Cefotaxime