227Th-EDTMP: a potential therapeutic agent for bone metastasis.
The biodistribution of 227Th-EDTMP and retention of its daughter nuclide 223Ra were examined. 227Th-EDTMP was found to show high uptake and long-term retention in bone. The clearance of 227Th-EDTMP from blood and soft tissues was rapid and the femur-to-tissue uptake ratios reached more than 100 within 30 min for all tissues except the kidney. Seven and 14 days after injection of 227Th-EDTMP, the retention index of 223Ra in bone showed high values, and the differences between these time points were not significant. Therefore, 227Th-EDTMP is a potential radiotherapeutic agent for bone metastasis.
School of Health Sciences, Faculty of Medicine, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan. kwashi@mhs.mp.kanazawa-u.ac.jp
Kohshin
K
Washiyama
Ryohei
R
Amano
Jun
J
Sasaki
Seigo
S
Kinuya
Norihisa
N
Tonami
Yoshinobu
Y
Shiokawa
Toshiaki
T
Mitsugashira
D000818:Animals; D001859:Bone Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D005240:Feasibility Studies; D005269:Femur / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008813:Mice, Inbred ICR; D009928:Organ Specificity; D009942:Organometallic Compounds / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D063065:Organophosphonates / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution
C499127:227Th-ethylenediamine-tetramethylenephosphonic acid; D009942:Organometallic Compounds; D063065:Organophosphonates; D019275:Radiopharmaceuticals