Association of blunted nighttime blood pressure dipping with coronary artery stenosis in men.
BACKGROUND
The aim of this work was to study the association between blunted nighttime dipping of blood pressure (BP) and coronary artery stenosis in men.


METHODS
Sixty-eight men (aged 52 +/- 11 years) with coronary artery disease (CAD) defined as >/=70% diameter stenosis, and a control group of 68 men, matched for age and risk factors without angiographic CAD were studied by ambulatory blood pressure monitoring. Patients were defined as nondippers when the nighttime systolic and diastolic BP decrease was <10%. Medications included beta-blockers in 20 (15%), calcium antagonists in 39 (29%), angiotensin-converting enzyme inhibitors in 44 (32%), angiotensin receptor blockers in 21 (15%), and diuretics in 37 (27%) patients. A logistic regression model was used to define independent predictors of angiographic CAD. Covariates were symptoms, total cholesterol, daytime BP, and nondipping.


RESULTS
A larger proportion of patients with CAD were nondippers as compared to control subjects (49 [72%] v 31 [46%], P < .005). In a logistic regression model, nondipping was associated with coronary artery stenosis independent of other clinical parameters (odds ratio 3.6, 95% confidence interval 1.6-8.8).


CONCLUSIONS
Blunted nighttime dipping of BP is independently associated with angiographic coronary artery stenosis in men.
Mousa
Tarek
T
Department of Physiology, University of Nebraska Medical Centre, Omaha, Nebraska, USA.
el-Sayed
Moustafa A
MA
Motawea
Ahmed K
AK
Salama
Mohsen A
MA
Elhendy
Abdou
A
D000787:Angina Pectoris; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D002940:Circadian Rhythm; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D011237:Predictive Value of Tests
D000959:Antihypertensive Agents