[Infiltrating lobular carcinoma of the breast with histiocytoid features: three cases].
Histiocytoid carcinoma of the breast, a cellular variant of invasive breast cancer, is mainly found among infiltrating lobular carcinomas (ILC). It can be easily confused with benign conditions or other mammary tumors also composed of cells with a pink granular to foamy cytoplasm and an eccentric nucleus. We report 3 cases of histiocytoid ILC. Our aim is to discuss recent immunocytochemical data that could suggest a special type of apocrine differentiation of tumor cells, including a diffuse immunoreactivity for GCDFP-15 (Gross Cystic Disease Fluid Protein 15) and a predominant expression of androgen receptor, and to describe the features useful for the differential diagnosis.
Laboratoire d'Anatomie et Cytologie Pathologiques Marcel Mérieux, Avenue Tony Garnier, 69007 Lyon. maugros@lab-merieux.fr
Marilyn
M
Augros
Annie
A
Buénerd
Mojgan
M
Devouassoux-Shisheboran
Gérard
G
Berger
D000368:Aged; D001053:Apolipoproteins; D053399:Apolipoproteins D; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D002352:Carrier Proteins / Q000032:analysis; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006644:Histiocytes / Q000737:chemistry / Q000648:ultrastructure; D006801:Humans; D008207:Lymphatic Metastasis; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D017698:Postmenopause; D011944:Receptors, Androgen / Q000032:analysis
C024328:APOD protein, human; D001053:Apolipoproteins; D053399:Apolipoproteins D; D002352:Carrier Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D009363:Neoplasm Proteins; C488892:PIP protein, human; D011944:Receptors, Androgen