Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity.
Modular polyketide synthases biosynthesise natural products through successive Claisen-type condensations, where one module is responsible for one round of chain extension. This review describes recent findings where this rule of co-linearity is broken, either by one module being bypassed (skipping) or through one module being used for multiple chain extension events (stuttering).
Biotica Technology Ltd., Chesterford Research Park, Little Chesterford, Essex, UK CB10 1XL. steven.moss@biotica.co.uk
Steven J
SJ
Moss
Christine J
CJ
Martin
Barrie
B
Wilkinson
D005075:Biological Evolution; D018942:Macrolides / Q000378:metabolism*; D008958:Models, Molecular; D048630:Polyketide Synthases / Q000737:chemistry / Q000145:classification / Q000235:genetics
D018942:Macrolides; D048630:Polyketide Synthases