The role of oxidants and antioxidants in generalized vitiligo at tissue level.
BACKGROUND
The role of oxidative stress has not been fully understood in the aetiopathogenesis of vitiligo in different studies.


OBJECTIVE
We aimed to investigate the role of the oxidative stress in the pathogenesis of vitiligo.


METHODS
In this study, we examined levels of superoxide dismutase, glutathione peroxidase, malondialdehyde and nitric oxide in tissue of 25 patients with generalized vitiligo and 25 healthy controls.


RESULTS
Our results revealed that levels of superoxide dismutase, glutathione peroxidase and malondialdehyde in tissue were significantly increased in patients with generalized vitiligo (P < 0.05). However, there was no statistically significantly difference between two groups at tissue level of nitric oxide (P > 0.05).


CONCLUSIONS
Our results demonstrate the presence of an imbalance in the oxidant-antioxidant system in vitiligo at tissue level and provide further support for a free radical-mediated damage as an initial pathogenic event in melanocyte degeneration in vitiligo.
Yildirim
M
M
Department of Dermatology, Faculty of Medicine, University of Suleyman Demirel, Isparta, Turkey. yildirim@med.sdu.edu.tr
Baysal
V
V
Inaloz
H S
HS
Can
M
M
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism*; D014820:Vitiligo / Q000201:enzymology / Q000378:metabolism*
D009569:Nitric Oxide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase