Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is a well-recognized form of chronic liver disease affecting both children and adults that has gained increased recognition. Recently NAFLD has been associated with insulin resistance and its incidence and prevalence is likely increasing, paralleling the rise in obesity and diabetes mellitus in the United States. The article includes current thoughts on the natural history and pathogenesis of NAFLD and describes current trends in the diagnosis and treatment of this condition.
Harrison
Stephen A
SA
Department of Gastroenterology and Hepatology, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA. Stephen.Harrison@cen.amedd.army.mil
Neuschwander-Tetri
Brent A
BA
D002908:Chronic Disease; D048909:Diabetes Complications; D005234:Fatty Liver / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006505:Hepatitis / Q000473:pathology*; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications; D015995:Prevalence