Severe calcification of mucocutaneous and gastrointestinal tissues induced by high dose administration of vitamin D in a puppy.
A three-month-old male Bull Terrier was referred to the Animal Medical Centre, Nihon University with chief complaints of subacute emesis and lethargy. Severe leukocytosis, high CRP, hypercalcemia and hypochloremia were detected. Moreover, severe calcification of gingival mucosa and abdominal skin, and abnormalities of the skeletal system were discerned. Abdominal X-ray and endoscopic examination revealed ulcer and hemorrhage on the mucosal membrane of the stomach. This might have been due to injections of high dose vitamin D at 3 and 2 weeks ago by another practioner, according to the detailed history of medication. After two months, a gastrointestinal and skin disorder disappeared, although calcification of the stomach membranes remained and abnormality of the skeletal system had worsened. Therefore, vitamin D should be carefully administrated to a puppy.
Department of Veterinary Internal Medicine, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan.
Yuka
Y
Nakamura
Mayumi
M
Gotoh
Yoshiko
Y
Fukuo
Akihiro
A
Takei
Takahiro
T
Noda
Akihiro
A
Murakami
Rui
R
Kano
Toshihiro
T
Watari
Mikihiko
M
Tokuriki
Atsuhiko
A
Hasegawa
Yoshihide
Y
Sasaki
D000818:Animals; D002114:Calcinosis / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced / Q000378:metabolism*; D004285:Dogs; D005552:Forelimb / Q000000981:diagnostic imaging; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D011859:Radiography; D012871:Skin Diseases / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D013270:Stomach / Q000000981:diagnostic imaging; D014807:Vitamin D / Q000009:adverse effects*
D014807:Vitamin D