Structurally simplified macrolactone analogues of halichondrin B.
A structurally simplified macrolactone analogue of halichondrin B was identified that retains the potent cell growth inhibitory activity of the natural product in vitro.
Seletsky
Boris M
BM
Department of Medicinal Chemistry, Eisai Research Institute, 4 Corporate Drive, Andover, MA 01810, USA.
Wang
Yuan
Y
Hawkins
Lynn D
LD
Palme
Monica H
MH
Habgood
Gregory J
GJ
DiPietro
Lucian V
LV
Towle
Murray J
MJ
Salvato
Kathleen A
KA
Wels
Bruce F
BF
Aalfs
Kimberley K
KK
Kishi
Yoshito
Y
Littlefield
Bruce A
BA
Yu
Melvin J
MJ
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004988:Ethers, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018942:Macrolides; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D000095662:Polyether Polyketides
D004988:Ethers, Cyclic; D007783:Lactones; D018942:Macrolides; C070519:halichondrin B; D000095662:Polyether Polyketides