Squamous cell carcinoma with sarcomatous stroma in the nasal cavity of a dog.
This is a report of an unusual squamous cell carcinoma in the nasal cavity of a dog. A 13-year-old Golden Retriever was presented with a unilateral nasal and ocular discharge. Although a nasal tumour was suspected, initial diagnostic investigations were unrewarding, and, with worsening clinical signs, the dog was euthanatized. Necropsy examination confirmed the presence of a nasal tumour that was composed histologically of both a well-differentiated squamous cell carcinoma component blending with a predominant spindle cell component. Immunohistochemical staining with anti-human keratin/cytokeratin (AE1/AE3, CAM 5.2 and broad spectrum cytokeratin), Vimentin, Desmin, smooth muscle actin and S-100 protein supported a diagnosis of a squamous cell carcinoma with (pseudo) sarcomatous stroma.
Faculty of Veterinary Science, University of Sydney, New South Wales 2006. kateb@camden.usyd.edu.au
K L
KL
Bosward
A E
AE
Kessell
R J
RJ
Lucy
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary; D009669:Nose Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D011859:Radiography; D012509:Sarcoma / Q000175:diagnosis / Q000662:veterinary*