Spectral analysis of burst periods in EEG from healthy and post-asphyctic full-term neonates.
OBJECTIVE
To investigate whether the periodic EEG patterns seen in healthy and sick full term neonates (trace alternant and burst suppression, respectively) have different frequency characteristics.


METHODS
Burst episodes were selected from the EEGs of 9 healthy and 9 post-asphyctic full-term neonates and subjected to power spectrum analysis. Powers in two bands were estimated; 0-4 and 4-30 Hz, designated low- and high-frequency activity, respectively (LFA, HFA). The spectral edge frequency (SEF) was also assessed.


RESULTS
In bursts, the LFA power was lower in periods of burst suppression as compared to those of trace alternant. The parameter that best discriminated between the groups was the relative amount of low- and high-frequency activity. The SEF parameter had a low sensitivity to the group differences. In healthy neonates, the LFA power was higher over the posterior right as compared to the posterior left region.


CONCLUSIONS
Spectral power of low frequencies differs significantly between the burst episodes of healthy and sick neonates.


CONCLUSIONS
These results can be used when monitoring cerebral function in neonates.
Institute of Clinical Neuroscience, Unit of Clinical Neurophysiology, Bla straket 7, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden. magnus.thordstein@neuro.gu.se
M
M
Thordstein
A
A
Flisberg
N
N
Löfgren
R
R
Bågenholm
K
K
Lindecrantz
B G
BG
Wallin
I
I
Kjellmer
D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000503:physiopathology*; D016022:Case-Control Studies; D004569:Electroencephalography; D006801:Humans; D007231:Infant, Newborn; D012680:Sensitivity and Specificity