Computational approach to systems biology: from fraction to integration and beyond.
Systems biology is an approach to understanding the workings of whole biological systems. The various methods used for systems analyses range from experimental to computational. In this paper, we describe basic concepts of systems biology, modeling challenges that arise from the massively parallel interaction among components in biological systems, and what lies beyond integration of modular knowledge.
Systems Biology Group, Bioinformatics Institute, Singapore 138671.
Pawan K
PK
Dhar
Hao
H
Zhu
Santosh K
SK
Mishra
D000818:Animals; D002468:Cell Physiological Phenomena; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D049490:Systems Biology / Q000379:methods* / Q000639:trends; D018511:Systems Integration