Modification of zearalenone structure in model and natural conditions.
Zearalenone is a mycotoxin widely occurring in cereals and animal feed, and it is associated with hyperestrogenism and other reprodutive disorders in animals. A new method of detoxication of feedstuffs involves alkaline hydrolysis of toxic macrolactone (1) (as well as model compounds (2a, 2b)). The method caused modification of zearalenone structure under mild conditions and the toxin underwent irreversible hydrolysis with high efficiency.
Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland. mgora@chemia.uj.edu.pl
M
M
Góra
M K
MK
Luczyński
L
L
Smoczyński
K
K
Obremski
M
M
Polak
M
M
Swist
L
L
Zielonka
M
M
Gajecki
D000821:Animal Feed; D000818:Animals; D005506:Food Contamination / Q000517:prevention & control; D015651:Mycotoxicosis / Q000517:prevention & control / Q000662:veterinary*; D013329:Structure-Activity Relationship; D013696:Temperature; D013997:Time Factors; D015025:Zearalenone / Q000737:chemistry* / Q000633:toxicity*
D015025:Zearalenone