Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria.
In an unmatched case-control study of 63 non-immune European patients with uncomplicated (n = 52) and complicated (n = 11) falciparum malaria, serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid-binding protein (H-FABP), myoglobin, troponin T and creatin kinase-muscle brain were compared. Elevated levels of NT-proBNP and H-FABP indicated myocardial impairment in complicated but not in uncomplicated falciparum malaria. The clinical impact of these findings remains to be evaluated. The pathophysiology of cardiac impairment in complicated falciparum malaria warrants further investigation.
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. ehrhardt@bni-hamburg.de
S
S
Ehrhardt
D
D
Wichmann
C J
CJ
Hemmer
G D
GD
Burchard
N W
NW
Brattig
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D009202:Cardiomyopathies / Q000097:blood / Q000469:parasitology*; D002352:Carrier Proteins / Q000097:blood; D016022:Case-Control Studies; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D050556:Fatty Acid-Binding Proteins; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications*; D009211:Myoglobin / Q000097:blood; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D020107:Troponin T / Q000097:blood
D015415:Biomarkers; D001798:Blood Proteins; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins; D007527:Isoenzymes; D009211:Myoglobin; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form