An analysis of type-III secretion gene clusters in Chromobacterium violaceum.
Chromobacterium violaceum is an environmental Gram-negative bacterium that is common in soil and water in tropical and sub-tropical regions. It is also a model organism for studying quorum-sensing and is a rare but deadly human pathogen. Recent completion of the genome sequence of C. violaceum strain ATCC 12472 revealed the presence of genes associated with type-III secretion systems (TTSSs). One of these systems resembles the Spi-1 system found in Salmonella enterica, whereas another is similar to the Spi-2 system from the same organism. Here, we present a detailed analysis and a fresh annotation of the two gene clusters. Moreover, we highlight the presence of several genes encoding putative type-III effector proteins that lead us to predict that this organism can manipulate vesicular trafficking, the actin cytoskeleton and apoptotic pathways within mammalian cells to its own advantage.
Betts
Helen J
HJ
Bacterial Pathogenesis and Genomics Unit, Division of Immunity and Infection, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham B15 2TT UK.
Chaudhuri
Roy R
RR
Pallen
Mark J
MJ
D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D002861:Chromobacterium / Q000235:genetics* / Q000502:physiology; D005798:Genes, Bacterial; D005810:Multigene Family; D021381:Protein Transport; D019779:Salmonella enterica / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D001426:Bacterial Proteins