An alternative evaluation method for swelling studies of bioadhesive tablet formulations.
A new and alternative evaluation method is preferred for swelling studies of bioadhesive tablet formulations. CIELAB color coordinates, related to visual color response, are used for the first time to follow the swelling state and to calculate the swelling volume. The results are evaluated statistically. A simple equation is given to explain the relation between the swelling volume change % and color difference for three different bioadhesive formulations. It was found that the estimated equation is in good agreement with observed swelling volume results.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Izmir, Turkey. baloglue@pharm.ege.edu.tr
E
E
Baloglu
S Y
SY
Hizarcioglu
H A
HA
Karavana
D000179:Acrylates; D000269:Adhesives; D000465:Algorithms; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003124:Colorimetry; D005079:Excipients; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D013607:Tablets
D000179:Acrylates; D000269:Adhesives; D005079:Excipients; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D013607:Tablets; C007894:guar gum; C453622:carbopol 934P