Synthesis of the bicyclo[7.3.0]dodecatrienediyne core of the C-1027 chromophore.
[reaction: see text] C-1027, an extremely potent antitumor agent, is composed of chromophore 1 and an apoprotein. Here we report a general and efficient route to the exceedingly reactive bicyclo[7.3.0]dodecatrienediyne core of 1, utilizing selenoxide elimination and epoxide deoxygenation to build the cyclopentadiene and enediyne structures, respectively.
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. inoue@ykbsc.chem.tohoku.ac.jp
Masayuki
M
Inoue
Suguru
S
Hatano
Masaki
M
Kodama
Takeo
T
Sasaki
Tsukasa
T
Kikuchi
Masahiro
M
Hirama