Primary myelofibrosis terminated in basophilic leukemia and successful allogeneic bone marrow transplantation.
Transformation of primary myelofibrosis (PMF) to basophilic leukemia is very rare. We report the case of a 44-year-old man who had had PMF for 6 years. His hematopoiesis deteriorated with marked splenomegaly, requiring multiple red blood cell and platelet transfusions. Soon after splenectomy, progressive basophilia (32.3 x 10(9)/L) developed, infiltrating the skin as well as the bone marrow. The patient underwent allogeneic bone marrow transplantation with cells from an HLA-matched sibling. Despite the presence of hyperhistaminemia (99.1 ng/mL) after conditioning with cyclophosphamide, the pregrafting and post-grafting periods were uneventful. Prophylactic administration of both H1 and H2 receptor antagonists and sufficient hydration appeared to be important.
Department of Hematology and Clinical Immunology, Kobe City General Hospital, Kobe, Japan.
Naoshi
N
Sugimoto
Takayuki
T
Ishikawa
Saori
S
Gotoh
Isaku
I
Shinzato
Akiko
A
Matsushita
Kenichi
K
Nagai
Noriko
N
Ohgoh
Takayuki
T
Takahashi
D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000379:methods* / Q000473:pathology; D006410:Hematopoiesis; D006801:Humans; D015471:Leukemia, Basophilic, Acute / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications* / Q000473:pathology