Mechanism of albuminuria associated with cardiovascular disease and kidney disease.
The major underlying factors associated with tissue damage and fibrosis in cardiovascular and kidney disease are the up-regulation and action of growth factors such as transforming growth factor-beta (TGF-beta) and cytokines produced in response to changes in systemic factors, particularly blood pressure or hyperglycemia. This study identifies the relationship of elevated levels of TGF-beta to increased levels of intact albumin in the urine (micro- and macroalbuminuria). This mechanism may be directly linked to the effect of TGF-beta on albumin uptake and the lysosomal breakdown of filtered albumin by proximal tubular cells prior to excretion.
Russo
Leileata M
LM
Program in Membrane Biology, Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
Comper
Wayne D
WD
Osicka
Tanya M
TM
D000419:Albuminuria / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000503:physiopathology*; D016326:Extracellular Matrix Proteins / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics; D053773:Transforming Growth Factor beta1; D000099222:betaIG-H3 Protein
D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D000099222:betaIG-H3 Protein