Current trends in the enhancement of biomaterial osteointegration: biophysical stimulation.
To enhance bone implant osteointegration, many strategies for improving biomaterial properties have been developed which include optimization of implant material, implant design, surface morphology and osteogenetic coatings. Other methods that have been attempted to enhance endogenous bone healing around biomaterials are different forms of biophysical stimulations such as pulsed electromagnetic fields (PEMFs) and low intensity pulsed ultrasounds (LIPUS), which were initially developed to accelerate fracture healing. To aid in the use of adjuvant biophysical therapies in the management of bone-implant osteointegration, the present authors reviewed experimental and clinical studies published in the literature over the last 20 years on the combined use of biomaterials and PEMFs or LIPUS, and summarized the methodology, and the possible mechanism of action and effectiveness of the different biophysical stimulations for the enhancement of bone healing processes around bone implanted biomaterials.
Fini
M
M
Department of Experimental Surgery, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute, Bologna, Italy.
Giavaresi
G
G
Setti
S
S
Martini
L
L
Torricelli
P
P
Giardino
R
R
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D004574:Electromagnetic Fields; D016348:Osseointegration; D010012:Osteogenesis; D019736:Prostheses and Implants; D014465:Ultrasonics
D001672:Biocompatible Materials