A case of Lambert-Eaton myasthenic syndrome associated with atypical bronchopulmonary carcinoid tumor.
The Lambert-Eaton myasthenic syndrome (LEMS) is typically recognized as a paraneoplastic syndrome associated with a small cell lung carcinoma (SCLC), whereas LEMS with other neuroendocrine lung tumors, including carcinoids or large cell lung carcinoma, are highly unusual. Here, we report a rare case of LEMS with atypical bronchopulmonary carcinoid tumor: a 65-yr-old man presented with progressive leg weakness and a diagnosis of LEMS was made by serial repetitive nerve stimulation test. Chest CT revealed a lung nodule with enlargement of paratracheal lymph nodes, and surgically resected lesion showed pathological features of atypical carcinoid tumor. We concluded that LEMS could be associated with rare pulmonary neuroendocrine tumor other than SCLC, which necessitates pathologic confirmation followed by aggressive treatment for optimal management in these rare cases.
Lee
Jae-Hyeok
JH
Department of Neurology, College of Medicine, Pusan National University, Busan, Korea.
Shin
Jin-Hong
JH
Kim
Dae-Seong
DS
Jung
Dae Soo
DS
Park
Kyu-Hyun
KH
Lee
Min-Ki
MK
Kim
Jee-Yeon
JY
D000368:Aged; D002276:Carcinoid Tumor / Q000150:complications* / Q000473:pathology / Q000601:surgery; D004576:Electromyography; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications* / Q000175:diagnosis; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008297:Male