Polyelectrolyte complex films derived from polyethyleneoxide-maleic acid copolymer and chitosan: preparation and characterization.
Polyelectrolyte complex films were prepared with polyethyleneoxide-maleic acid copolymer and chitosan using a casting/solvent evaporation method. The films were examined in terms of their IR spectra, surface and cross-section morphologies, cytotoxicity, and swelling behavior at different pH levels. To assess the potential of these films as a biomedical device, the profiles of the release of model drug from the CS/PEOMA films were examined at pH 4.8. The surface morphology of the films was quite smooth and uniform, and the cross-sectional morphology was dense and homogeneous. The swelling behaviors of CS/PEOMA films were found to depend on the pH of the solution as well as on the CS/PEOMA composition. Drug release from different CS/PEOMA films at pH 4.8 was found to be dependent on film composition. The results showed the potential applicability of CS/PEOMA film as a drug delivery vehicle.
Department of International Development Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8550, Japan. yshin-ya@kuramae.ne.jp
Yoshitsune
Y
Shin-Ya
Hideo
H
Tsurushima
Taro
T
Tsurumi
Toshio
T
Kajiuchi
Kam W
KW
Leong
D000042:Absorption; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008298:Maleates / Q000009:adverse effects / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014116:Toxicology; D014867:Water
D008298:Maleates; D014867:Water; D011092:Polyethylene Glycols; D048271:Chitosan; C030272:maleic acid