Somatostatin signal transduction in thyroid parafollicular C cells.
The effects of somatostatin (SRIF) through its receptors (SSTRs) has been explored in many tissues, and here we discuss the role of the SRIF-SSTR system in human parafollicular C cells, reporting recent data on the effects of selective SSTR agonists on parafollicular C cells, that suggest new therapeutic approaches for medical treatment of medullary thyroid carcinoma. Moreover, the possible pathways involved in SRIF signalling in parafollicular C cells are discussed.
Zatelli
M C
MC
Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy.
degli Uberti
E C
EC
D000818:Animals; D006801:Humans; D017481:Receptors, Somatostatin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013004:Somatostatin / Q000494:pharmacology / Q000502:physiology*; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D017481:Receptors, Somatostatin; D013004:Somatostatin