Peering into the birth canal during ion channel parturition.
Recent studies have provided detailed structures of the N-terminal T1 domain of Kv channel alpha subunits that mediates contranslational subunit assembly. In this issue of Neuron, Kosolapov et al. probe T1 domain structure within the ribosomal tunnel. They find that the T1 domain forms secondary structure within the tunnel, in preparation for its immediate role in governing channel assembly upon exit.
Department of Pharmacology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
James S
JS
Trimmer
D000818:Animals; D006801:Humans; D024642:Potassium Channels, Voltage-Gated / Q000737:chemistry* / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D017433:Protein Structure, Secondary; D021122:Protein Subunits / Q000737:chemistry* / Q000502:physiology; D012270:Ribosomes / Q000502:physiology
D024642:Potassium Channels, Voltage-Gated; D021122:Protein Subunits