Synthesis and characterization of partially biodegradable and thermosensitive hydrogel.
A partially biodegradable and thermosensitive hybrid hydrogel network (DAN series) based on dextran-allylisocyanate (Dex-AI) and poly(N-isopropylacrylamide) (PNIPAAm) was synthesized via UV photocrosslinking. These hybrid hydrogels were characterized in terms of their chemical structure, thermal, mechanical, morphological and temperature-induced swelling properties. The effect of the composition ratio of Dex-AI to PNIPAAm on such properties were examined. The differential scanning calorimetry data show that this Dex-AI/PNIPAAm hybrid network has an increased lower critical solution temperature (LCST) and glass transition temperature (Tg) with an increase in the Dex-AI content. The interior morphology of these hybrid hydrogels revealed a decreased porous microstructure with an increase in the Dex-AI content in the hybrid network. Furthermore, if the Dex-AI composition became too high, a distinctive network structure with two different microporous structures appeared. The mechanical properties of these hybrid hydrogels also increased with an increase in the Dex-AI content. The temperature dependence of the swelling ratio, the deswelling kinetics as well as the reswelling kinetics was also characterized by gravimetric method. When comparing with a normal PNIPAAm hydrogel, these Dex-AI/PNIPAAm hybrid networks, due to the presence of Dex-AI moiety, also show improved temperature-induced intelligent properties, such as the faster and controllable response dynamics, which may find promising applications in a wide variety of fields, such as biomedical and bioengineering fields.
Department of Textiles and Apparel and Biomedical Engineering Program, Cornell University, Ithaca, New York 14853-4401, USA.
Xian-Zheng
XZ
Zhang
Guo-Ming
GM
Sun
Da-Qing
DQ
Wu
Chih-Chang
CC
Chu
D020341:Absorbable Implants; D000042:Absorption; D000180:Acrylic Resins / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D022081:Cell Surface Extensions; D019245:Compressive Strength; D003911:Dextrans / Q000737:chemistry*; D004058:Diffusion; D004548:Elasticity; D020100:Hydrogels / Q000737:chemistry*; D017953:Isocyanates / Q000737:chemistry*; D007700:Kinetics; D008422:Materials Testing; D008968:Molecular Conformation; D009997:Osmotic Pressure; D044367:Phase Transition; D016062:Porosity; D013696:Temperature; D044366:Transition Temperature; D014867:Water / Q000737:chemistry*
D000180:Acrylic Resins; D000498:Allyl Compounds; D001672:Biocompatible Materials; D003911:Dextrans; D020100:Hydrogels; D017953:Isocyanates; C491149:allyl isocyanate; D014867:Water; C052970:poly-N-isopropylacrylamide