[The Use of Clopidogrel in Conjunction With Thrombolytic Therapy in PatientsWith ST-Elevation Acute Myocardial Infarction.].
Clopidogrel (300 mg before initiation of thrombolysis and 75 mg/day thereafter) was given to 46 of 131 patients with streptokinase treated ST-elevation acute myocardial infarction. Mortality and efficacy of thrombolysis were similar in 2 groups, however deaths of acute heart failure were distributed unevenly (0 in clopidogrel group and 8 or 9.4% among other patients, p <0.03). Clopidogrel treated compared with other patients had significantly higher left ventricular ejection fraction on days 1-2 of disease (52.5+/-2.2 and 45.9+/-2.0%, respectively, p<0.03). Number of bleedings did not differ significantly between 2 groups. Thus patients addition of clopidogrel to aspirin and thrombolysis with streptokinase was associated with better myocardial contractile function and lower mortality due to acute heart failure.
Dyskin
Iu A
IuA
Moscow State Medical Dental University; ul. Delegatskaya 20, 103473 Moscow, Russia.
Makarycheva
O V
OV
Vasil'eva
E Iu
EIu
Shpektor
A V
AV
D001241:Aspirin / Q000627:therapeutic use; D006801:Humans; D009203:Myocardial Infarction; D013300:Streptokinase / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D016277:Ventricular Function, Left
D013300:Streptokinase; D001241:Aspirin