The structure of an endosomal protein sorter.
Three "endosomal sorting complexes required for transport," ESCRT-I, -II, and -III, mediate sorting of ubiquitinated membrane proteins into intraluminal endosomal vesicles that are destined for degradation in lysosomes. Two recent reports, one in Nature and one in this issue of Developmental Cell, reveal the crystal structure of the yeast form of ESCRT-II.
Slagsvold
Thomas
T
Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway.
Stenmark
Harald
H
D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D019281:Dimerization; D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000737:chemistry* / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008566:Membranes / Q000378:metabolism; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D021381:Protein Transport / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000737:chemistry; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism; D033921:Vesicular Transport Proteins; D016335:Zinc Fingers
D002352:Carrier Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D008081:Liposomes; D008565:Membrane Proteins; C094045:SNF8 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D025801:Ubiquitin; D014452:Ubiquitins; D033921:Vesicular Transport Proteins; C491125:Vps25 protein, S cerevisiae; C491128:Vps36 protein, S cerevisiae