Clear cell and non-clear cell hepatocellular carcinoma: a case report and literature review.
Clear cell hepatocellular carcinoma (HCC) is an uncommon variant of HCC. It is considered to have a better prognosis than non-clear cell HCC, but recent large studies show that there is some controversy. DNA image cytometry reveals diploid and non-diploid DNA content tumors that have different pleomorphisms and mitosis corresponding to different prognoses. Clear cell HCC is classified as focal or diffuse. Herein, we report a rare case of a 61-year-old male with two adjacent hyper- and hypoechoic hepatic nodules and an alpha-fetoprotein concentration of 6,370 ng/mL. Pathologic examination of a specimen obtained during wedge hepatectomy showed both clear cell and non-clear cell HCC. Bone metastasis was later found. We suggest that a patient with clear cell HCC should be followed up closely after complete resection.
Division of Gastroenterology, Shalu Kuang-Tien Hospital, Taichung, Taiwan. liujeha@ms1.hisky.com.tw
Jenn-Hwa
JH
Liu
Huey-Ling
HL
Tsai
Soa-Ming
SM
Hsu
Dong-Her
DH
Hu
Shy-Shen
SS
Chen
D000792:Angiography; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018227:Sarcoma, Clear Cell / Q000175:diagnosis*; D014463:Ultrasonography