Protein- and gene-based tissue engineering in bone repair.
A tissue engineering approach to bone regeneration includes the use of a scaffold, cells and bioactive factors alone or in various combinations. Several investigators have demonstrated enhanced bone formation when the tissue-engineered construct possesses traits inherent to autogenic bone grafts, namely osteoconductivity, osteoinductivity and osteogenicity. Use of the biodegradable polymer poly(lactide-co-glycolide) in combination with bone morphogenetic protein or primary cells genetically modified to release osteogenic protein have demonstrated the ability to induce osteogenic differentiation of, and subsequent mineralization by, muscle-derived cells and mesenchymal stem cells in both in vitro and in vivo applications.
Kofron
Michelle D
MD
Li
Xudong
X
Laurencin
Cato T
CT
D000818:Animals; D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D001861:Bone Regeneration; D016503:Drug Delivery Systems / Q000379:methods; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D023822:Tissue Engineering / Q000379:methods; D014945:Wound Healing
D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D011100:Polyglycolic Acid