Adrenocortical responses to tumor necrosis factor-alpha and interferon-gamma in cattle.
The responses of plasma cortisol and adrenocorticotropic hormone (ACTH) were examined to intravenous injection of recombinant bovine tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma) in Holstein cows. INF-gamma induced dose-dependent rises in the plasma levels of both cortisol and ACTH, while TNF-alpha induced comparable plasma cortisol responses with much smaller rises in plasma ACTH. The results suggest a direct stimulatory action of TNF-alpha on cortisol secretion from the adrenal gland in cattle.
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. ahmed276@vetmed.hokudai.ac.jp
Mohamed
M
Soliman
Shiki
S
Okamoto
Hiroshi
H
Kitamura
Shiro
S
Kushibiki
Kazuhiro
K
Kimura
Masayuki
M
Saito
D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000493:pharmacokinetics; D000818:Animals; D002417:Cattle / Q000097:blood / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006854:Hydrocortisone / Q000097:blood* / Q000493:pharmacokinetics; D007275:Injections, Intravenous / Q000662:veterinary; D007371:Interferon-gamma / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000494:pharmacology*
D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone