Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora.
To evaluate the pharmacological actions of herbal medicines, metabolic activities of herbal medicine components, ginsenoside Rb1, glycyrrhizin, geniposide and baicalin to their bioactive compounds compound K, 18beta-glycyrrhetic acid, genipin and baicalein by fecal specimens were measured. Their metabolic activities were 646.1+/-591.4, 29.4+/-51.7, 926.3+/-569.6 and 3884.6+/-1400.1 micromol/h/g, respectively. The profiles of these metabolic activities of baicalin and ginsenoside Rb1 were not significantly different to those of water extracts of Scutellariae Radix and Ginseng Radix. None of the metabolic activities tested were different between males and females, or between ages. However, the difference in these metabolic activities in individuals was significant. These results suggest that the human intestinal microflora enzymes that convert herbal components to their bioactive compounds may be used as selection markers of responders to traditional medicines.
Yim
Jang-Shim
JS
College of Oriental Medicine, Kyung Hee University, Dongdaemun-ku, Seoul, Korea.
Kim
Young-Suk
YS
Moon
Sang-Kwan
SK
Cho
Ki-Ho
KH
Bae
Hyung-Sup
HS
Kim
Jung-Jin
JJ
Park
Eun-Kyung
EK
Kim
Dong-Hyun
DH
D000328:Adult; D002855:Chromatography, Thin Layer; D005243:Feces / Q000382:microbiology*; D005260:Female; D044950:Flavanones / Q000378:metabolism; D005419:Flavonoids / Q000378:metabolism*; D036145:Ginsenosides / Q000378:metabolism*; D006034:Glycyrrhetinic Acid / Q000737:chemistry / Q000378:metabolism; D019695:Glycyrrhizic Acid / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D057889:Iridoid Glycosides; D039823:Iridoids / Q000378:metabolism*; D008297:Male; D005894:Panax; D010936:Plant Extracts / Q000378:metabolism; D011714:Pyrans / Q000378:metabolism*; D031364:Scutellaria baicalensis; D013237:Stereoisomerism
D044950:Flavanones; D005419:Flavonoids; D036145:Ginsenosides; D006034:Glycyrrhetinic Acid; D019695:Glycyrrhizic Acid; D057889:Iridoid Glycosides; D039823:Iridoids; D010936:Plant Extracts; D011714:Pyrans; C007835:geniposide; C038044:baicalin; C006680:baicalein; C442759:ginsenoside Rb1; C007834:genipin; C112772:ginsenoside compound K