[Effect of anti-infective reconstituted bone xenograft as primary bone grafting on repair of contaminated radius defect in canine].
OBJECTIVE
To investigate the effect of anti-infective reconstituted bone xenograft (ARBX) as primary grafting on repair of a segmental contaminated defect in canine radius.


METHODS
The contaminated segmental defects of 1.5 cm were made in both radius of 8 canine and 1 ml of staphylococal suspension was injected into the defect region at a concentration of 5 x 10(6) CFU/ml. ARBX(experimental side) or RBX(control side) was implanted into the two sides of the defects respectively as primary grafting followed by internal fixation. The results were compared between the two grafting materials in repairing the contaminated segmental defect.


RESULTS
In ARBX side, the defects were repaired completely in 5 cases and partially in 1 case, and there existed no osteomyelitis in all cases; while in RBX side, the defects were repaired partially in 1 case and were not repaired in 5 cases after 6 months of operation, and there existed osteomyelitis in all cases.


CONCLUSIONS
Besides its strong osteoinductive and osteoconductive activity, ARBX is highly antibacterial and can be used as primary grafting in repairing contaminated segmental defects.
Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi 710032, PR China.
Zhi
Z
Yuan
Yunyu
Y
Hu
Jian
J
Liu
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D004285:Dogs; D005839:Gentamicins / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control; D011884:Radius / Q000293:injuries / Q000601:surgery*; D013530:Surgical Wound Infection / Q000601:surgery*; D014183:Transplantation, Heterologous
D000900:Anti-Bacterial Agents; D005839:Gentamicins