Synthesis and study of naphthacenedione (TQ) as a photosensitizer for one-electron oxidation of DNA.
[reaction: see text] Photosensitizers are useful for the study of one-electron oxidation of DNA. Most such photosensitizers absorb light in the UV spectral region. We report the synthesis and investigation of a 5,12-naphthacenedione (TQ) derivative as a DNA photosensitizer. Irradiation of a TQ-linked duplex with visible light results in reaction of the DNA that is characteristic of one-electron oxidation. The results from TQ sensitization are identical, within experimental error, with that of a well-studied anthraquinone derivative.
Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Lezah W
LW
Roberts
Gary B
GB
Schuster
D004247:DNA / Q000737:chemistry*; D004583:Electrons; D009279:Naphthacenes / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D017319:Photosensitizing Agents / Q000138:chemical synthesis*; D013056:Spectrophotometry, Ultraviolet
D009279:Naphthacenes; D017319:Photosensitizing Agents; D004247:DNA