Dopamine receptors in C. elegans.
Dopamine regulates various physiological functions in the central nervous system and the periphery. Dysfunction of the dopamine system is implicated in a wide variety of disorders and behaviors including schizophrenia, addiction, and attention-deficit hyperactivity disorder. Medications that modulate dopamine signaling have therapeutic efficacy on the treatment of these disorders. However, the causes of these disorders and the role of dopamine are still unclear. Studying the dopamine system in a model organism, such as Caenorhabditis elegans, allows the genetic analysis in a simple and well-described nervous system, which may provide new insight into the molecular mechanisms of dopamine signaling. In this review, we summarize recent findings on pharmacological and biochemical properties of the C. elegans dopamine receptors and their physiological role in the control of behavior.
Laboratory of Molecular Neurobiology, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada.
Satoshi
S
Suo
Shoichi
S
Ishiura
Hubert H M
HH
Van Tol
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D005786:Gene Expression Regulation; D011954:Receptors, Dopamine / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D011954:Receptors, Dopamine; D004298:Dopamine