Characteristics of the increase in plasma brain natriuretic peptide level in left ventricular systolic dysfunction, associated with muscular dystrophy in comparison with idiopathic dilated cardiomyopathy.
To determine whether the plasma brain natriuretic peptide level increases differentially in muscular dystrophy and idiopathic dilated cardiomyopathy, we investigated the plasma brain natriuretic peptide level and echocardiographic parameters in patients with similarly low left ventricular ejection fraction. The plasma brain natriuretic peptide level was lower, and the left ventricular end-diastolic diameter was shorter in the patients with muscular dystrophy than in those with idiopathic dilated cardiomyopathy. The correlation between the plasma brain natriuretic peptide and left ventricular ejection fraction was shifted downward in the patients with muscular dystrophy compared with those with idiopathic dilated cardiomyopathy. Those between the brain natriuretic peptide and left ventricular end-diastolic diameter were superimposable, although the data from the muscular dystrophy patients were located at the shorter left ventricular end-diastolic diameter side. The plasma brain natriuretic peptide level may differentially increase in the two diseases with similar left ventricular systolic dysfunction. Differences in the left ventricular distension and in the physical activity might explain at least partially the different plasma brain natriuretic peptide levels.
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Jun
J
Demachi
Yutaka
Y
Kagaya
Jun
J
Watanabe
Masahito
M
Sakuma
Jun
J
Ikeda
Yasunori
Y
Kakuta
Iyoko
I
Motoyoshi
Takeshi
T
Kohnosu
Hiroaki
H
Sakuma
Shigeru
S
Shimazaki
Hideaki
H
Sakai
Teiko
T
Kimpara
Toshiaki
T
Takahashi
Kiyoshi
K
Omura
Miho
M
Okada
Hiroshi
H
Saito
Kunio
K
Shirato
D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000150:complications; D004452:Echocardiography / Q000379:methods; D005260:Female; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015592:Immunoradiometric Assay / Q000379:methods; D008297:Male; D009133:Muscular Atrophy / Q000097:blood* / Q000150:complications; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D018709:Statistics, Nonparametric; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000150:complications / Q000209:etiology
D020097:Natriuretic Peptide, Brain