Endocrine tumors of the gut and pancreas tumor biology and classification.
The endocrine tumors of the gut and pancreas tract are a group of neoplasms composed of cells with a neuroendocrine phenotype. Well-differentiated tumors, well-differentiated carcinomas and poorly differentiated carcinomas are the major categories identified. According to their localization (stomach, duodenum-jejunum, ileum, appendix and colorectum), they display distinct phenotypes, regarding their pathology, immunohistochemistry and hormonal syndromes. Their clinical behavior spans from benign, uncertain malignant potential, low-grade malignant to high-grade malignant. Currently, extensive work is performed to unravel the genetic background.
Rindi
G
G
Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Parma, Italy. guido.rindi@unipr.it
Klöppel
G
G
D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D019858:Enteroendocrine Cells / Q000378:metabolism / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000145:classification* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D018358:Neuroendocrine Tumors / Q000145:classification* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000145:classification* / Q000473:pathology
D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins