Vasohibin: the feedback on a new inhibitor of angiogenesis.
Angiogenesis is regulated in large part by the balance of various proangiogenic stimulators, such as VEGF, and a diverse group of endogenous inhibitors of angiogenesis, most of which are extrinsic to endothelial cells. With respect to the latter, until recently, none have appeared to be induced as a consequence of a specific, self-regulating, feedback inhibition response. A new inhibitor, called vasohibin, has been uncovered. Vasohibin is selectively induced in endothelial cells by proangiogenic stimulatory growth factors such as VEGF; it appears to operate as an intrinsic and highly specific feedback inhibitor of activated endothelial cells engaged in the process of angiogenesis.
Sunnybrook and Women's College Health Sciences Centre and the University of Toronto, Ontario, Canada. robert.kerbel@swchsc.on.ca
Robert S
RS
Kerbel
D020533:Angiogenesis Inhibitors / Q000378:metabolism*; D000818:Animals; D018797:Cell Cycle Proteins; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018919:Neovascularization, Physiologic; D011506:Proteins / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D018797:Cell Cycle Proteins; D011506:Proteins; C493181:VASH1 protein, human; D042461:Vascular Endothelial Growth Factor A