Association of DAAO with schizophrenia in the Chinese population.
Recently, the gene called DAAO was reported to be associated with schizophrenia in the French Canadian populations. Here, we report a result obtained in the study of our large collection of 547 schizophrenia cases and 536 controls in the Chinese population. Six single-nucleotide polymorphisms (SNPs) were genotyped at and around the DAAO locus, covering a 10-kb region entirely encompassing the complementary DNA sequences of DAAO. We found statistically significant differences in allele distributions on one marker: SNP rs3741775 (P = 0.0000001). In the haplotype analysis based on the information of linkage-disequilibrium block across this gene locus, we demonstrated a highly significant association between schizophrenia and a DAAO haplotype (P = 2.0173 x 10(-21)), which therefore provides an independent statistical support for association of the DAAO gene with schizophrenia and indicates that the DAAO gene may play a significant role in the etiology of schizophrenia in the Han Chinese.
Bio-X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, 1954 Huashan Road, P.O. Box 501, Shanghai 200030, PR China.
Xinmin
X
Liu
Guang
G
He
Xiaoyan
X
Wang
Qi
Q
Chen
Xueqing
X
Qian
Wei
W
Lin
Dawei
D
Li
Niufan
N
Gu
Guoyin
G
Feng
Lin
L
He
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D003605:D-Amino-Acid Oxidase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012559:Schizophrenia / Q000235:genetics*
D012333:RNA, Messenger; D003605:D-Amino-Acid Oxidase