[ATP receptors in pain sensation].
We reported that activation of P2X2/3 heteromeric channels in A delta-DRG neurons causes tactile allodynia and activation of P2X3 in C-fiber causes nocifensive behavior. We also found that tactile allodynia under the chronic pain state requires an activation of P2X4 ionotropic ATP receptor and p38 mitogen-activated protein kinase in spinal microglia.
Division of Biosignaling, National Institute of Health Sciences, Tokyo 158-8501, Japan.
Kazuhide
K
Inoue
Makoto
M
Tsuda
Schuichi
S
Koizumi
D000818:Animals; D005727:Ganglia, Spinal / Q000502:physiology; D017628:Microglia / Q000502:physiology; D009434:Neural Pathways; D009619:Nociceptors / Q000502:physiology*; D020671:Posterior Horn Cells / Q000502:physiology; D051381:Rats; D018048:Receptors, Purinergic P2 / Q000502:physiology*
D018048:Receptors, Purinergic P2