Effect of drug-loading methods on drug load, encapsulation efficiency and release properties of alginate/poly-L-arginine/chitosan ternary complex microcapsules.
The drug-loaded alginate/poly-L-arginine/chitosan ternary complex microcapsules were prepared by mixing method, absorption method and the combined method of mixing and absorption, respectively. The effect of drug-loading methods on drug load, the encapsulation efficiency and the release properties of the complex microcapsules were investigated. The results showed that the absorption process is a dominating factor to greatly increase the drug load of Hb into microcapsules. Upon loading Hb into microcapsules by combined method of mixing and absorption, the drug load (19.9%) is up to the maximum value, and the encapsulation efficiency is 93.8%. Moreover, the drug release is a zero-order kinetics process for the ternary complex microcapsules made by mixing. For the complex microcapsules made by absorption, the drug release is a first-order kinetics. However, for the complex microcapsules made by combining the mixing and the absorption, the drug release obeys a first-order kinetics during the first eighteen hours, changing afterwards to a zero-order kinetics process. Effect of drug-loading methods on drug load and encapsulation efficiency of alginate/poly-L-arginine/chitosan ternary complex microcapsules.
College of Materials Science and Engineering, Huaqiao University, Quanzhou, Fujian 362011, China. sbwang@hqu.edu.cn
Shi-Bin
SB
Wang
Ai-Zheng
AZ
Chen
Lian-Jin
LJ
Weng
Mei-Ying
MY
Chen
Xiao-Lin
XL
Xie
D000464:Alginates / Q000737:chemistry; D000818:Animals; D001120:Arginine / Q000737:chemistry; D002214:Capsules / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D002417:Cattle; D048271:Chitosan / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D020723:Glucuronic Acid / Q000737:chemistry; D006454:Hemoglobins / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry
D000464:Alginates; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006454:Hemoglobins; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D048271:Chitosan; D001120:Arginine