Preparation of naltrexone hydrochloride loaded poly (DL-lactide-co-glycolide) microspheres and the effect of polyvinyl alcohol (PVA) as surfactant on the characteristics of the microspheres.
The aim of this study was to investigate the effect of the surfactant properties of polyvinyl alcohol (PVA) in enhancing the yield of small size microspheres. Naltrexone microspheres were prepared by solvent-solvent extraction evaporation process. PVA of various concentrations were added into the aqueous phase prior to the mixing process. The addition of PVA was expected to influence the shape, size distribution, drug loading and drug release profile. The results indicated that it is desirable to increase the weight fraction of the microspheres with size range below 106 mm for the highest possible yield.
Suhaida
M G
MG
Biomaterial Groups, AMREC, SIRIM Berhad.
Yahya
I B
IB
Darmawati
M Y
MY
D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000032:analysis / Q000138:chemical synthesis*; D006016:Glycolates / Q000032:analysis / Q000138:chemical synthesis*; D006801:Humans; D019344:Lactic Acid; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009271:Naltrexone / Q000032:analysis / Q000138:chemical synthesis*; D010316:Particle Size; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011142:Polyvinyl Alcohol / Q000032:analysis / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000032:analysis / Q000138:chemical synthesis*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006016:Glycolates; D013501:Surface-Active Agents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D009271:Naltrexone; D011142:Polyvinyl Alcohol