Binary CaO-SiO(2) gel-glasses for biomedical applications.
Bioactive materials are routinely used in dental and orthopaedic applications. The concept was first introduced in 1971, with the discovery of 45S5 Bioglass, which is known to develop an interfacial bond between the implant and the host tissue. This glass is composed of SiO(2), CaO, P(2)O(5) and Na(2)O. Since then numerous glasses and glass ceramics with similar compositions have been extensively studied for clinical applications. Until 1990 it was accepted that P(2)O(5) and Na(2)O were necessary components for the glass composition to be bioactive. However, calcium silicate glasses with high SiO(2) content are impossible to produce using the traditional melt-quench method. This is due to the liquid-liquid immiscibility region that is present between 0.02 and 0.3 mole fraction of CaO and in terms of bioactivity, high CaO compositions were inferior to those quaternary bioactive glass compositions already in existence. In the last few years several studies have been reported regarding the production of CaO-SiO(2) glasses via the sol-gel processing technique. This report summarises the findings of the past and the present and also outlines potential of these calcium silicate gel-glasses in the field of biomaterials.
Tissue Engineering and Regenerative Medicine Centre, Department of Materials, Imperial College London, UK. p.pavan@imperial.ac.uk
Priya
P
Saravanapavan
Julian R
JR
Jones
Sophie
S
Verrier
Robert
R
Beilby
Victoria J
VJ
Shirtliff
Larry L
LL
Hench
Julia M
JM
Polak
D000818:Animals; D001698:Biomedical Engineering / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D018786:Bone Substitutes / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry*; D002516:Ceramics; D005139:Eyeglasses; D005782:Gels / Q000737:chemistry; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D019736:Prostheses and Implants; D017640:Silicates / Q000737:chemistry*; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods* / Q000639:trends
D018786:Bone Substitutes; D017610:Calcium Compounds; D005782:Gels; D017640:Silicates; C425330:bioactive glass 45S5; C031293:calcium silicate