Structurally simplified macrolactone analogues of halichondrin B.
A structurally simplified macrolactone analogue of halichondrin B was identified that retains the potent cell growth inhibitory activity of the natural product in vitro.
Department of Medicinal Chemistry, Eisai Research Institute, 4 Corporate Drive, Andover, MA 01810, USA.
Boris M
BM
Seletsky
Yuan
Y
Wang
Lynn D
LD
Hawkins
Monica H
MH
Palme
Gregory J
GJ
Habgood
Lucian V
LV
DiPietro
Murray J
MJ
Towle
Kathleen A
KA
Salvato
Bruce F
BF
Wels
Kimberley K
KK
Aalfs
Yoshito
Y
Kishi
Bruce A
BA
Littlefield
Melvin J
MJ
Yu
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004988:Ethers, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018942:Macrolides; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D000095662:Polyether Polyketides
D004988:Ethers, Cyclic; D007783:Lactones; D018942:Macrolides; C070519:halichondrin B; D000095662:Polyether Polyketides