Cytokines: making the right choice.
Fred Finkelmon and Joseph Urban propose that optimal host defense against different classes of parasite depends upon induction of different sets of immune effector mechanisms, which are, in turn, dependent upon secretion of different sets of cytokines. The authors suggest that hosts identify characteristics common to parasites of a given type as those triggers that stimulate secretion of the proper cytokine set.
Division of Immunology and Rheumatology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
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Finkelman
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Urban