A male patient with steroid-dependent nephrotic syndrome for 25 years and obesity-associated focal segmental glomerulosclerosis.
An obese male patient with steroid-dependent nephrotic syndrome since age 6 years had a thirty-third relapse at the age of 29 years. Renal biopsy showed focal segmental glomerulosclerosis. Proteinuria disappeared after treatment with prednisolone. He went into complete remission and renal function remained normal at the age of 31 years. Focal segmental glomerulosclerosis associated with obesity was suspected. Long-term follow-up with renal biopsy is necessary in obese children with steroid-dependent nephrotic syndrome.
First Department of Pediatrics, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan.
Osamu
O
Motoyama
Atsuhiko
A
Muto
Hidetaka
H
Ogiwara
Sonoo
S
Mizuiri
Sadao
S
Kawamura
Kikuo
K
Iitaka
D000375:Aging / Q000502:physiology; D015992:Body Mass Index; D002648:Child; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D009765:Obesity / Q000150:complications*; D012008:Recurrence; D013256:Steroids / Q000627:therapeutic use*
D013256:Steroids