[Effect of cyclooxygenase-2,and matrix metalloproteinase-2 expression on prognosis of lung cancer].
OBJECTIVE
Expression of cyclooxygenase-2 (COX-2)and matrix metalloproteinase-2 (MMP-2)increased in most tumor tissues. Inhibitors of both COX-2 and MMP-2 have been experimentally and clinically proved effective against the development of tumor. Our study was designed to investigate the expression of COX-2 and MMP-2, and the effect of those proteins on lymphoid metastasis and prognosis of lung cancer.


METHODS
SP immunohistochemistry was used to determine the expression of COX-2 and MMP-2 in 42 patients with lung cancer. Kaplan-Meier and log-rank test were used to compare the survival time of positive staining group and negative staining group.


RESULTS
The positive rate of COX-2 was 31%, and that of MMP-2 was 62%. The survival time in positive COX-2 group was significantly shorter than that in negative COX-2 group (P=0.019). The lymphoid metastasis rate of positive MMP-2 group was significantly higher than that of negative MMP-2 group (P=0.009). The survival time in positive MMP-2 group was significantly shorter than that in negative MMP-2 group (P=0.001). No relationship was found between the expression of COX-2 and MMP-2 (P=0.257).


CONCLUSIONS
The expression of COX-2 and MMP-2 are closely correlate with the prognosis of lung cancer, and the over-expression of those proteins suggest poor prognosis in patients with lung cancer.
Department of Cardiothoracic Surgery,Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, P.R.China.
Hui-Zhong
HZ
Zhang
Zhi-Qiang
ZQ
Lu
De-Rong
DR
Xie
Hai-Gang
HG
Li
Li-Hua
LH
Xiong
Hua
H
Zhang
Xiao-Bing
XB
Chen
D000230:Adenocarcinoma / Q000201:enzymology* / Q000556:secondary; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000556:secondary; D051546:Cyclooxygenase 2; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008565:Membrane Proteins; D008875:Middle Aged; D011379:Prognosis; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D015996:Survival Rate
D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D020778:Matrix Metalloproteinase 2