Plasma testosterone and sexual function in men receiving buprenorphine maintenance for opioid dependence.
High-dose methadone is well known to cause testosterone deficiency and sexual dysfunction in opioid-dependent men. Buprenorphine is a new drug for the pharmacotherapy of opioid dependence. Its influence on the gonadal axis has not been investigated to date. We therefore assayed testosterone, free testosterone, estradiol, SHBG, LH, FSH, and prolactin in 17 men treated with buprenorphine. Thirty-seven men treated with high-dose methadone and 51 healthy blood donors served as controls. Sexual function and depression were assessed using a self-rating sexual function questionnaire and the Beck Depression Inventory. Patients treated with buprenorphine had a significantly higher testosterone level [5.1 +/- 1.2 ng/ml (17.7 +/- 4.2 nmol/liter) vs. 2.8 +/- 1.2 ng/ml (9.7 +/- 4.2 nmol/liter); P < 0.0001] and a significantly lower frequency of sexual dysfunction (P < 0.0001) compared with patients treated with methadone. The testosterone level of buprenorphine-treated patients did not differ from that of healthy controls. In conclusion, we demonstrated for the first time that buprenorphine, in contrast with high-dose methadone, seems not to suppress plasma testosterone in heroin-addicted men. To this effect, buprenorphine was less frequently related to sexual side effects. Buprenorphine might therefore be favored in the treatment of opioid dependence to prevent patients from the clinical consequences of methadone-induced hypogonadism.
Department of Clinical Biochemistry, Division of Endocrinology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany. nbliesener@yahoo.com
Niclaas
N
Bliesener
Susanne
S
Albrecht
Andra
A
Schwager
Klaus
K
Weckbecker
Dirk
D
Lichtermann
Dietrich
D
Klingmüller
D000328:Adult; D002047:Buprenorphine / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood; D006801:Humans; D008297:Male; D008691:Methadone / Q000009:adverse effects; D009293:Opioid-Related Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D012725:Sexual Behavior / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D002047:Buprenorphine; D004958:Estradiol; D008691:Methadone