DNA cleavage induced by thermal electron transfer from a dimeric NADH analogue to acridinium ions in the presence of oxygen.
Acridinium ions, which can intercalate to DNA, act as thermal DNA cleavers in the presence of a dimeric NADH analogue and O2 in an aqueous solution via thermal electron transfer from a dimeric NADH analogue to acridinium ions, followed by the electron-transfer reduction of O2 to O2*- by the resulting NAD radicals.
Fukuzumi
Shunichi
S
Department of Material and Life Science, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan. fukuzumi@chem.eng-osaka-u.ac.jp
Yukimoto
Kazusa
K
Ohkubo
Kei
K
D000166:Acridines / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D007700:Kinetics; D009243:NAD / Q000031:analogs & derivatives* / Q000737:chemistry; D009536:Niacinamide / Q000031:analogs & derivatives / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
D000166:Acridines; D009243:NAD; D013481:Superoxides; D009536:Niacinamide; D004247:DNA; D010100:Oxygen