Successful allogeneic bone marrow transplantation in a patient with acute myelogenous leukemia and cytomegalovirus retinitis.
A 1-year-old boy with acute myeloid leukemia with cytomegalovirus (CMV) retinitis that was refractory because of severely impaired cellular immunity underwent bone marrow transplantation from an HLA-matched donor after a conditioning regimen of busulfan, cyclophosphamide, and etoposide. Although we continued administration of ganciclovir from preparation therapy, retinitis worsened after engraftment. Thereafter retinitis improved gradually as the number of CD4+ T-lymphocytes increased. The findings in this case suggest that stem cell transplantation for a leukemia patient with CMV disease may be effective.
Matsubara
Hiroshi
H
Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan. matsu-ncc@umin.ac.jp
Adachi
Souichi
S
Yano
Jun
J
Kitamura
Noriko
N
Miyazaki
Maki
M
Mizushima
Yasuhiro
Y
Hiramatsu
Hidefumi
H
Kobayashi
Michihiro
M
Nakahata
Tatsutoshi
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000502:physiology*; D017726:Cytomegalovirus Retinitis / Q000150:complications* / Q000188:drug therapy; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D008297:Male; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D000998:Antiviral Agents; D015774:Ganciclovir