[Molecular biology for familial Parkinson's disease].
Parkinson's disease (PD) is the second most common neurodegenerative disorders. Recently, several forms of familial PD have been reported so far. Among them, several causative genes such as alpha-synuclein, UCH-L1, PINK1, and DJ-1 have been identified. Functional analysis on these causative genes may help us to explore the molecular mechanisms of nigral neuronal death in not only FPD but also sporadic form of PD. Thus, the identification of FPD gives us good information of etiologies of PD.
Shiba
Kahori
K
Research Institute for Diseases of Old Ages, Juntendo University School of Medicine.
Hattori
Nobutaka
N
D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics*; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases / Q000235:genetics; D051843:Synucleins; D043222:Ubiquitin Thiolesterase / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D051844:alpha-Synuclein; D000099202:PTEN-Induced Putative Kinase
D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D015513:Oncogene Proteins; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases; D051843:Synucleins; D043222:Ubiquitin Thiolesterase; D044767:Ubiquitin-Protein Ligases; D051844:alpha-Synuclein; D000099202:PTEN-Induced Putative Kinase; C497604:SNCA protein, human; C482860:UCHL1 protein, human; C111567:parkin protein; C105131:PARK7 protein, human