Monitoring haemophilia severity and treatment: new or old laboratory tests?
Testing of factor levels is desirable for a number of reasons, including diagnosis of the level of severity of the disease, and the efficacy of factor-replacement therapy. The older methods comprised the one-stage, two-stage, and chromogenic methods, and newer methods, including the thrombin generation test, are now available. This paper outlines the use of these methods and problems associated with them.
Barrowcliffe
T W
TW
NIBSC, Potters Bar, UK. tbarrowcliffe@nibsc.au.uk
D001803:Blood Transfusion; D019411:Clinical Laboratory Techniques; D005169:Factor VIII / Q000032:analysis*; D006403:Hematologic Tests / Q000379:methods; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D012720:Severity of Illness Index; D013917:Thrombin / Q000032:analysis
D005169:Factor VIII; D013917:Thrombin