Synthesis of (-)-noviose from 2,3-O-isopropylidene-D-erythronolactol.
Noviose is a key synthon for the construction of novobiocin, a clinically useful antitumor agent that has been shown to inhibit both type II topoisomerases and Hsp90. The synthesis of d-noviose from 2,3-O-isopropylidene-d-erythronolactol is described.
Department of Medicinal Chemistry and The Center for Protein Structure and Function, The University of Kansas, 1251 Wescoe Hall Drive, Malott Hall 4070, Lawrence, Kansas 66045-7564, USA.
Xiao Ming
XM
Yu
Gang
G
Shen
Brian S J
BS
Blagg
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009005:Monosaccharides / Q000138:chemical synthesis*; D009675:Novobiocin / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
C494072:2,3-O-isopropylidene-D-erythronolactol; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D006574:Heterocyclic Compounds, 2-Ring; D009005:Monosaccharides; C494073:noviose; D009675:Novobiocin