Chemoattractant signaling in dictyostelium discoideum.
Dictyostelium is an accessible organism for studies of signaling via chemoattractant receptors. Chemoattractant-mediated signaling events and components are reviewed and presented as a series of connected modules, including excitation, inhibition, G protein-independent responses, early gene expression, inositol lipids, PH domain-containing proteins, cyclic AMP signaling, polarization acquisition, actin polymerization, and cortical myosin. The network incorporates information from biochemical, genetic, and cell biological experiments carried out on living cells. The modules and connections represent current understanding, and future information is expected to modify and build upon this structure.
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Carol L
CL
Manahan
Pablo A
PA
Iglesias
Yu
Y
Long
Peter N
PN
Devreotes
D000199:Actins / Q000378:metabolism; D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002630:Chemotactic Factors / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004023:Dictyostelium / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D009218:Myosins / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism / Q000502:physiology; D015800:Protozoan Proteins / Q000737:chemistry / Q000378:metabolism; D011554:Pseudopodia / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
D000199:Actins; D002630:Chemotactic Factors; D010716:Phosphatidylinositols; D015800:Protozoan Proteins; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D009218:Myosins