[Combined effect of agonists and antagonists of the membranes channels on hemodynamic indices in rats with normal blood pressure and spontaneous hypertension].
It has been investigated the influence of synthesized in Institute of Organic Chemistry NA of Science fluorinated Compound "C" on haemodynamic indexes of normotensive (Wistar) and hypertensive (SHR) rats. Molecules of Compound 'C' contain the blocker of calcium channels foridon and the potassium channels activator flocalin. It was shown that separately used foridon (0.5 mg/kg) and flocalin (which has dose-depended effect) evoke hypertensive reaction, decreasing the total peripheral resistance. They differently affect the systolic blood volume (foridon decreases and flocalin increases) but do not change the heart rate. Compound "C" (0.5 mg/kg) decreases arterial pressure and total peripheral vessels resistance, decreases heart rate and increases systolic blood volume. In hypertensive animals these effects were more pronounced in comparison with normotensive animals.
Tarasova
K V
KV
Karvats'kyĭ
I M
IM
Shevchuk
V H
VH
Iahupol's'kyĭ
L M
LM
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004562:Electrocardiography; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D015221:Potassium Channels / Q000819:agonists*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004338:Drug Combinations; D015221:Potassium Channels