Triphenyl phosphine adducts of platinum(IV) and palladium(II) dithiocarbamates complexes: a spectral and in vitro study.
Triphenyl phosphine adducts of dithiocarbamate complexes of platinum(IV) and palladium(II) of the type [Pt(L)2PPh3Cl2] and [Pd(L)2PPh3] [L: morpholine dithiocarbamate (L1), aniline dithiocarbamate (L2) and N-(methyl, cyclohexyl) dithiocarbamate (L3)] were prepared and characterized by elemental analysis, electronic, IR, 1H NMR and 13C NMR spectral studies. Thermal studies of the complexes were carried out. In vitro antitumor activity has been screened towards human adenocarcinoma cell lines and showed significant inhibition even at very low concentration.
Department of Chemistry, University of Delhi, 110007, India. navneet92@rediffmail.com
N
N
Manav
A K
AK
Mishra
N K
NK
Kaushik
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008024:Ligands; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D013057:Spectrum Analysis; D013696:Temperature; D013730:Terphenyl Compounds / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D008024:Ligands; D010720:Phosphines; D013730:Terphenyl Compounds; D013859:Thiocarbamates; D010984:Platinum; D010165:Palladium; C044646:phosphine