Ena/VASP family: new partners, bigger enigma.
Linking external signals to remodeling of the cytoskeleton is essential to multiple processes during animal development and physiology. Two new studies have uncovered a new family of proteins that can regulate actin dynamics both locally at the membrane interface and globally throughout the cell.
Division of Cell Biology, Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, United Kingdom.
Maryse
M
Bailly
D000199:Actins / Q000378:metabolism; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001665:Binding Sites; D015815:Cell Adhesion Molecules / Q000737:chemistry* / Q000378:metabolism; D003285:Contractile Proteins / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D008840:Microfilament Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000737:chemistry* / Q000378:metabolism; D051304:Profilins; D011392:Proline / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011554:Pseudopodia / Q000378:metabolism; D015398:Signal Transduction; D014615:Vaccinia / Q000378:metabolism; D020827:rap1 GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D000098662:Vasodilator-Stimulated Phosphoprotein
D000199:Actins; D015815:Cell Adhesion Molecules; D003285:Contractile Proteins; C102177:Evl protein, mouse; D016023:Integrins; D008024:Ligands; D008840:Microfilament Proteins; D010750:Phosphoproteins; D051304:Profilins; D000098662:Vasodilator-Stimulated Phosphoprotein; D011392:Proline; D020558:GTP Phosphohydrolases; D020827:rap1 GTP-Binding Proteins