Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers.
The forearm blood flow (FBF) responses to acetylcholine and to sodium nitroprusside were evaluated before and after administration of edaravone in 10 smokers and 10 nonsmokers. FBF response to acetylcholine was lower in smokers than in nonsmokers. The vasodilatory effects of sodium nitroprusside were similar in both groups. Co-infusion of edaravone increased the FBF response to acetylcholine in smokers, but did not affect the FBF response to acetylcholine in nonsmokers. The administration of N(G)-monomethyl-l-arginine abolished edaravone-induced augmentation of the FBF response to acetylcholine in smokers. The antioxidative agent edaravone increases nitric oxide mediated vasodilation through a decrease in oxidative stress.
Jitsuiki
Daisuke
D
Department of Cardiovascular Physiology and Medicine, Hiroshima University, Hiroshima, Japan.
Higashi
Yukihito
Y
Goto
Chikara
C
Kimura
Masashi
M
Noma
Kensuke
K
Hara
Keiko
K
Nakagawa
Keigo
K
Oshima
Tetsuya
T
Chayama
Kazuaki
K
Yoshizumi
Masao
M
D000109:Acetylcholine / Q000494:pharmacology; D000328:Adult; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000077553:Edaravone; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D012907:Smoking / Q000503:physiopathology*; D014664:Vasodilation / Q000187:drug effects*; D019323:omega-N-Methylarginine / Q000494:pharmacology
D016166:Free Radical Scavengers; D009599:Nitroprusside; D019323:omega-N-Methylarginine; D000109:Acetylcholine; D000077553:Edaravone; D000983:Antipyrine