Clinical management of medulloblastoma in adults.
Although medulloblastoma is the most common malignant brain tumor in children, 30% of cases occur in adults. Recent therapeutic advances in the treatment of average-risk childhood medulloblastoma have emphasized the reduction of treatment-related toxicity while improving progression-free survival. However, lessons learned from the pediatric experience have not been widely applied to the adult population in Phase II or randomized clinical trials. This review will compare adult and pediatric medulloblastoma, highlight case series of adults treated at major academic institutions, and suggest directions for the contemporary management of adults with medulloblastoma.
Department of Pediatrics & Child Health, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Room 5016, Winnipeg, Manitoba, R3E 0V9, Canada. eisensta@cc.umanitoba.ca
David D
DD
Eisenstat
D000328:Adult; D017668:Age of Onset; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D002648:Child; D002986:Clinical Trials as Topic; D018450:Disease Progression; D006801:Humans; D008527:Medulloblastoma / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D013534:Survival
D000970:Antineoplastic Agents