Analysis of irises with a latanoprost-induced change in iris color.
OBJECTIVE
To study the histologic aspects of irises subjected to extended latanoprost treatment.


METHODS
Prospective, observer-masked study.


METHODS
Iris biopsies of eyes treated with latanoprost were analyzed (all had a photographically documented increase in iris pigmentation) plus control eyes (untreated with prostanoids) using optical microscopy. PATIENT OR STUDY POPULATION: There were 14 study eyes treated with latanoprost and 8 untreated control eyes.


METHODS
The morphologic characteristics of the irises.


RESULTS
The irises treated with latanoprost had an increased number of melanocytes with nuclear inclusions, granules of melanin in the vascular walls and the melanocytes and free granules in the stroma compared with control eyes (P = .001, P = .01, P = .004, P = .01, respectively, by the chi(2) test).


CONCLUSIONS
Chronic therapy with latanoprost appears to induce more changes in the iris than a simple increase in the melanin content of the melanocytes.
Hospital Oftalmológico Internacional de Madrid, Madrid, Spain. esther-arranz@ole.com <esther-arranz@ole.com>
Esther
E
Arranz-Marquez
Miguel A
MA
Teus
M Antonia
MA
Saornil
M Carmen
MC
Mendez
Raquel
R
Gil
D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001706:Biopsy; D017889:Exfoliation Syndrome / Q000188:drug therapy; D005127:Eye Color / Q000187:drug effects; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D007498:Iris / Q000187:drug effects / Q000473:pathology*; D007499:Iris Diseases / Q000139:chemically induced / Q000473:pathology*; D000077338:Latanoprost; D008297:Male; D008543:Melanins / Q000032:analysis; D008544:Melanocytes / Q000473:pathology; D008548:Melanosis / Q000139:chemically induced / Q000473:pathology*; D008875:Middle Aged; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*
D000959:Antihypertensive Agents; D008543:Melanins; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost