Genetic polymorphism of glutathione S-transferase P1 and breast cancer risk.
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted on Korean women. The study population consisted of 171 histologically confirmed incident breast cancer cases and 171 age-matched controls with no present or previous history of cancer. PCR-RFLP was used for the GSTP1 genotyping and statistical evaluations were performed using an unconditional logistic regression model. Postmenopausal women with the GSTP1 Val allele were found to have a reduced risk of breast cancer (OR = 0.3, 95 % CI = 0.10-0.74). A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95 % CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95 % CI = 0.27-0.93). Our findings suggest that the GSTP1 polymorphism influences individual susceptibility to breast cancer in the Korean women and this effect may be modified by alcohol consumption.
Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, 28 Yongon-Dong, Chongno-Gu, Seoul, 110-799, Korea.
Sook-Un
SU
Kim
Kyoung-Mu
KM
Lee
Sue-Kyung
SK
Park
Keun-Young
KY
Yoo
Dong-Young
DY
Noh
Kook-Jin
KJ
Choe
Sei-Hyun
SH
Ahn
Ari
A
Hirvonen
Daehee
D
Kang
D000328:Adult; D000368:Aged; D044466:Asian People; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008593:Menopause; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase