[Adrenoleukodystrophy: single voxel MR spectroscopy findings (case report)].
Adrenoleukodystrophy is a rare genetic disorder. Histopathological features of this disorder include demyelination and axonal loss in white matter. We describe a six-year-old boy with significantly decreased N-acetyl-aspartate (NAA)/Creatin (Cr), increased Choline (Cho)/Cr and Myo-inositol (MI)/Cr in parieto-occipital white matter by MR spectroscopy. In contrast to the normal appearance of frontal white matter on MR imaging, increased Cho/Cr and MI/Cr ratios were detected on MR spectroscopy. These changes in involved areas could be an indication of neuroaxonal loss, demyelination and gliosis.
Inönü Universitesi Tip Fakültesi, Turgut Ozal Tip Merkezi, Radyodiagnostik Anabilim Dali, Malatya, Turkey.
Alpay
A
Alkan
Ramazan
R
Kutlu
Mehmet
M
Aslan
Cengiz
C
Yakinci
D000326:Adrenoleukodystrophy / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male