Convenient magnesiation of aromatic and heterocyclic rings bearing a hydroxy group in presence of LiCl.
The reaction of various iodophenols with MeMgCl in presence of LiCl followed by the addition of i-PrMgCl provides the corresponding magnesiated magnesium phenolates as THF soluble reagents; this approach can be extended to heterocyclic compounds bearing a hydroxy group like pyridines and quinolines.
Department Chemie, Ludwig-Maximilians-Universität München, Germany.
Felix
F
Kopp
Arkady
A
Krasovskiy
Paul
P
Knochel