[Antihyperalgesic activity of chlorimipramine and sodium phenytoin in an induced model of neuropathic pain in rats].
BACKGROUND
Neuropathic pain results from injury or impairment of the nervous system manifested by pain syndrome. Experimental models have been used to study its effects and how to suppress these. Tricyclic antidepressants (TCA) and anticonvulsant (AC) have been used for treatment.


OBJECTIVE
To evaluate the antihyperanalgesic efficiency of intraperitoneal (IP) chlorimipramine (CIP) vs IP phenytoine (DFH) for induced neuropathic pain in an experimental animal model.


METHODS
After making a surgical ligature of the sciatic nerve in the right leg of 18 male rats, the time of withdrawal of both claws immersed in hot (45 degrees C) and cold water (10 degrees C) was measured during a four week period before and after IP CIP, DFH, or placebo administered in a double blind study.


RESULTS
Significant statistical differences were observed in the time of withdrawal with CIP as compared with DFH and when both groups were compared with placebo (as tested by the paw immersion in hot water). When the thermal stimulus was cold water, an increase of the time of withdrawal was seen with DFH.


CONCLUSIONS
These findings suggest that CIP and FS are both effective in the treatment of neuropathic pain in an animal model, as well as for the treatment of secondary hiperalgesia.
Guevara-López
Uriah
U
Jefe de la Unidad de Medicina del Dolor y Paliativa, INCMNSZ, Médico Anestesiólogo Algólogo, Hospital de Traumatología Victorio de la Fuente Narváez, IMSS. uriahguevara@hotmail.com
Gutiérrez-Sougarret
Bernardo
B
López-Pavón
Lucy
L
Aldrete
J Antonio
JA
Tamayo-Valenzuela
Antonio
A
D000818:Animals; D002997:Clomipramine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000188:drug therapy*; D008297:Male; D009422:Nervous System Diseases / Q000150:complications; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D010672:Phenytoin / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D010672:Phenytoin; D002997:Clomipramine