Movement disorders in pregnancy.
Movement disorders are not particularly common during pregnancy, with a few exceptions. RLS occurs most commonly followed by CG. Currently, with the incidence of rheumatic fever lower than previously, any woman who develops CG should be checked for illness other than rheumatic heart disease. The differential includes systemic lupus erythromatosis and antiphospholipid antibody syndrome. Regarding the use of dopaminergic agents, the dopamine agonist, pergolide, can be maintained during pregnancy for the treatment of PD, Segawa disease, and RLS. The use of levodopa and ropinirole should be limited during pregnancy because of the possible teratogenic effects. Amantadine is contraindicated during pregnancy. The data on selegiline are controversial; animal studies show possible serotonergic effects and teratogenic effects. If treatment is indicated in patients who have Tourette syndrome, the high potency neuroleptics drugs (haloperidol) are preferred to treat associated symptoms. Depression is a common comorbidity in patients who have PD, HD,Tourette syndrome, or other chronic neurologic diseases. Depression treatment during pregnancy is covered by Levy et al elsewhere in this issue. As discussed previously, most of the data on the use of drugs during pregnancy, especially the dopaminergic agents, are limited to animal studies and case reports. Therefore, it is in part left to the neurologist to decide on treatment based on the individual patient, clinical judgment, and inferences from animal studies and limited case reports.
Smith
Marsha S A
MS
Emory University School of Medicine, Atlanta, GA, USA.
Evatt
Marian L
ML
D014150:Antipsychotic Agents / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009069:Movement Disorders / Q000145:classification / Q000188:drug therapy / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists