Determination of d-alpha-tocopherol and its impurity by chiral high performance liquid chromatography in pharmaceutical preparations.
In the present study we used chiral high performance liquid chromatography to determine d-alpha-tocopherol and its impurity in vitamin preparations. A chiralcel OD-H column was used for the chiral separation. Statistical evaluation of the results established a high accuracy and precision of this method.
Kłaczkow
Gabriela
G
National Institute of Public Health, Department of Biochemistry and Biopharmaceuticals 30/34 Chełmska Str., 00-725 Warsaw, Poland.
Jakoniuk
Dorota
D
Anuszewska
Elzbieta L
EL
D000975:Antioxidants / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004340:Drug Contamination; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013237:Stereoisomerism; D024505:Tocopherols / Q000032:analysis*
D000975:Antioxidants; D004364:Pharmaceutical Preparations; D024505:Tocopherols