Is an ephedrine caffeine treatment contraindicated in hypertension?
OBJECTIVE
To examine how the slimming drug, Letigen, containing ephedrine (E) 20 mg and caffeine (C) 200 mg (E + C), affects blood pressure in normotensive and hypertensive patients treated with adrenergic beta-receptor blocking drugs and/or other antihypertensive agents, during a period of six weeks.


METHODS
A double-blind, randomised, placebo controlled study of five parallel groups of overweight patients from general practices.


METHODS
One hundred and thirty-six patients with Body Mass Index (BMI) > 25 kg/m2 were included consecutively by 25 general practitioners in Denmark and randomized into five groups: (1) Hypertensive patients treated with betablockers and E + C; (2) Hypertensive patients treated with antihypertensive agents other than betablockers, and E + C; (3) Normotensive patients treated with E + C; (4) Hypertensive patients under any antihypertensive treatment + placebo; and (5) Normotensive patients + placebo. All patients were instructed in a 1200 kcal (= 5040 kj) diet.


RESULTS
Of a total of 136 patients aged 20-74 y, 112 completed the study protocol. Fluctuations in systolic and diastolic blood pressure were seen in all groups. The systolic blood pressure was reduced significantly (5.5 mmHg) in the patients treated with antihypertensive agents other than betablockers, plus E + C. In the other hypertensive groups the reduction in blood pressure was not significant. In normotensive patients treated with E + C, the systolic and the diastolic blood pressure declined significantly (4.4/3.9 mmHg). At the end of the treatment period heart rate had increased significantly (4.9 beats/min) in the group of normotensive patients treated with E + C. Blood pressure and heart rate measured by the patient at home showed similar fluctuations from baseline prior to and during treatment with E + C or placebo. A mean loss of weight of approximately 4 kg in 6 weeks was significant for all the groups. There was no significant difference between the groups during this short period of treatment. In 56% of the patients treated with E + C complaints/side-effects related to the medical treatment were found at questioning. Corresponding complaints occurred in 21% of the placebo treated patients. In the E + C treated group 7% dropped out due to side-effects. In the placebo group there were no drop-outs.


CONCLUSIONS
This study does not support the assumption that E + C should cause rises in blood pressure, acutely or during shortterm treatment, in either normotensive or hypertensive obese patients. The antihypertensive effect of the betablockers was not reversed by E + C.
Geriatric Department, Bispebjerg Hospital, Copenhagen, Denmark.
J
J
Ingerslev
T L
TL
Svendsen
A
A
Mørk
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001067:Appetite Depressants; D002110:Caffeine / Q000009:adverse effects*; D016009:Chi-Square Distribution; D000075202:Contraindications; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004809:Ephedrine; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists; D001067:Appetite Depressants; D004338:Drug Combinations; C029944:caffeine, ephedrine drug combination; D002110:Caffeine; D004809:Ephedrine