Unusual neuro-ophthalmologic findings in a patient with anti-Yo-associated cerebellar degeneration.
We report a woman with anti-Yo-associated cerebellar degeneration, severe eye movement abnormalities, and no evidence of malignancy after 3 years of extensive evaluation. The prominent neuro-ophthalmologic findings suggest brainstem involvement, which may be a novel manifestation of anti-Yo associated paraneoplastic syndrome.
Cohen
Adam B
AB
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Zupa-Fernandez
Adriana
A
Dalmau
Josep
J
Galetta
Steven L
SL
D015153:Blotting, Western / Q000379:methods; D002526:Cerebellar Diseases / Q000150:complications* / Q000276:immunology; D004268:DNA-Binding Proteins / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology*; D009419:Nerve Tissue Proteins; D015835:Ocular Motility Disorders / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000276:immunology; D012189:Retrospective Studies
C095184:CDR2 protein, human; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins