Scaling the amplitudes of the circadian pattern of resting oxygen consumption, body temperature and heart rate in mammals.
We questioned whether the amplitudes of the circadian pattern of body temperature (T(b)), oxygen consumption (V (O(2))) and heart rate (HR) changed systematically among species of different body weight (W). Because bodies of large mass have a greater heat capacitance than those of smaller mass, if the relative amplitude (i.e., amplitude/mean value) of metabolic rate was constant, one would expect the T(b) oscillation to decrease with the increase in the species W. We compiled data of T(b), V (O(2)) and HR from a literature survey of over 200 studies that investigated the circadian pattern of these parameters. Monotremata, Marsupials and Chiroptera, were excluded because of their characteristically low metabolic rate and T(b). The peak-trough ratios of V (O(2)) (42 species) and HR (35 species) averaged, respectively, 1.57+/-0.08, and 1.35+/-0.07, and were independent of W. The daily high values of T(b) did not change, while the daily low T(b) values slightly increased, with the species W; hence, the high-low T(b) difference (57 species) decreased with W (3.3 degrees C.W(-0.13)). However, the decrease in T(b) amplitude with W was much less than expected from physical principles, and the high-low T(b) ratio remained significantly above unity even in the largest mammals. Thus, it appears that in mammals, despite the huge differences in physical characteristics, the amplitude of the circadian pattern is a fixed (for V (O(2)) and HR), or almost fixed (for T(b)), fraction of the 24-h mean value. Presumably, the amplitudes of the oscillations are controlled parameters of physiological significance.
Mortola
Jacopo P
JP
Department of Physiology, McGill University, 3655, Sir William Osler Promenade Montreal, Quebec, Canada, H3G 1Y6. jacopo.mortola@mcgill.ca
Lanthier
Clement
C
D000818:Animals; D001683:Biological Clocks; D055592:Biophysical Phenomena; D001703:Biophysics; D001831:Body Temperature; D001833:Body Temperature Regulation; D001835:Body Weight; D002940:Circadian Rhythm; D006339:Heart Rate; D006358:Hot Temperature; D008322:Mammals / Q000033:anatomy & histology* / Q000502:physiology*; D008991:Monitoring, Physiologic; D010101:Oxygen Consumption; D012119:Respiration; D013696:Temperature