Anti-IgE therapy in children with asthma.
The prevalence of asthma continues to grow rapidly among children in areas undergoing urbanization. Current pharmacotherapy for asthma reduces inflammation and provides symptomatic relief, but it does not work for all patients and it does not entirely suppress the underlying disease. For these reasons new therapeutic approaches are still needed. Anti-IgE, the newest therapeutic modality for asthma, a biologic agent to control allergic disorders, represents a fundamentally new concept in treatment.
Milgrom
H
H
Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA. milgromh@njc.org
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000888:Antibodies, Anti-Idiotypic; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology*; D002648:Child; D004195:Disease Models, Animal; D006801:Humans; D007073:Immunoglobulin E / Q000187:drug effects* / Q000276:immunology*; D008137:Longitudinal Studies; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D008875:Middle Aged; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D012138:Respiratory Therapy; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D018926:Anti-Allergic Agents; D018927:Anti-Asthmatic Agents; D000888:Antibodies, Anti-Idiotypic; D010919:Placebos; C026408:anti-IgE antibodies; D007073:Immunoglobulin E