Concurrent focal hepatic and splenic lesions: a pictorial guide to differential diagnosis.
Although medical literature and differential diagnoses discussions tend to be organ specific, systemic diseases more commonly manifest with multi-organ involvement. Detection of dual organ involvement combined with clinical history narrows the differential to provide a more specific diagnosis. Two organs closely linked are the liver and the spleen. Many processes affect both of these organs through their common denominator, the reticuloendothelial system (RES). This pictorial essay reviews the wide spectrum of benign and malignant pathologies to be considered when computed tomography (CT) demonstrates concurrent focal disease in the liver and spleen.
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 601 North Caroline Street, Room 3140 A, Baltimore, MD 21287, USA. mbean3@jhmi.edu
Marchelle J
MJ
Bean
Karen M
KM
Horton
Elliot K
EK
Fishman
D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000000981:diagnostic imaging; D002177:Candidiasis / Q000150:complications / Q000000981:diagnostic imaging; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005776:Gaucher Disease / Q000150:complications / Q000000981:diagnostic imaging; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000150:complications* / Q000000981:diagnostic imaging* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D010382:Peliosis Hepatis / Q000150:complications / Q000000981:diagnostic imaging; D016720:Pneumocystis Infections / Q000150:complications / Q000000981:diagnostic imaging; D011857:Radiographic Image Interpretation, Computer-Assisted; D012507:Sarcoidosis / Q000150:complications / Q000000981:diagnostic imaging; D013158:Splenic Diseases / Q000150:complications* / Q000000981:diagnostic imaging* / Q000382:microbiology; D014057:Tomography, X-Ray Computed