Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.
We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.
Federation de Rhumatologie, Hopital Lariboisiere, Paris, France. pascal.richette@lrb.ap-hop-paris.fr
Pascal
P
Richette
Philippe
P
Dieudé
Joël
J
Damiano
Frédéric
F
Lioté
Philippe
P
Orcel
Thomas
T
Bardin
D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D009475:Neurons, Afferent / Q000473:pathology*; D011129:Polyradiculoneuropathy / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D020293:Vasculitis, Central Nervous System / Q000139:chemically induced / Q000473:pathology
D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab