Paracoccidioidomycosis in a woman with idiopathic hirsutism.
Paracoccidioidomycosis, especially the chronic pulmonary form of the disease, is not commonly described in females. Data from in vitro and vivo studies support the hypothesis that estrogens might influence the pathogenesis of paracoccidioidomycosis in humans by inhibition of transition of conidia or mycelia to yeast form of Paracoccidioides brasiliensis. The authors describe a chronic progressive pulmonary form of paracoccidioidomycosis in a woman with idiopathic hirsutism. In addition to estrogens, the present report suggests that other hormonal factors might play an important role in the pathogenesis of paracoccidioidomycosis, including the increased production of 5alpha-dehydrotestosterone frequently described in individuals with idiopathic hirsutism.
Infectious Diseases Unit, and Endocrinology Section, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
Rodrigo Pires
RP
dos Santos
Ana Luiza
AL
Maia
Luciano Z
LZ
Goldani
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006628:Hirsutism / Q000150:complications* / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D010228:Paracoccidioides / Q000254:growth & development*; D010229:Paracoccidioidomycosis / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D013739:Testosterone / Q000031:analogs & derivatives* / Q000096:biosynthesis
D000935:Antifungal Agents; D017964:Itraconazole; D013739:Testosterone; C013915:boldenone; D000666:Amphotericin B