Spherical molecularly imprinted polymers (SMIPs) via a novel precipitation polymerization in the controlled delivery of sulfasalazine.
Spherical molecularly imprinted polymers (SMIPs) have been prepared via a novel precipitation polymerization using sulfasalazine (prodrug used in the diseases of the colon) as template. The sulfasalazine was incorporated into SMIPs and into a spherical non-imprinted polymer (control), and then the release rate of the bioactive agent at different pH values was evaluated. Considerable differences in the release characteristics between imprinted and non-imprinted polymers have been observed. This opens the possibility of the development of drug release systems capable of modulating the release of a specific molecule. Photomicrography of spherical molecularly imprinted polymers (SMIPs).
Puoci
F
F
Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy. francesco.puoci@unical.it
Iemma
F
F
Muzzalupo
R
R
Spizzirri
U G
UG
Trombino
S
S
Cassano
R
R
Picci
N
N
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems; D008689:Methacrylates / Q000737:chemistry*; D008863:Microspheres; D009570:Nitriles / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012460:Sulfasalazine / Q000008:administration & dosage / Q000737:chemistry*; D013678:Technology, Pharmaceutical
D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D008689:Methacrylates; D009570:Nitriles; D011108:Polymers; C008384:methacrylic acid; D012460:Sulfasalazine; C004919:ethylene dimethacrylate; C004526:azobis(isobutyronitrile)