Malaria sporozoites: survival, transmission and disease control.
A basic fact in malariology is that human malaria infections result from the bite of an infective anopheline mosquito. Without sporozoite transmission there is no malaria. Here, John Beier highlights our understanding of sporozoite biology from the perspective of how sporozoites develop and survive in mosquitoes, how they are transmitted during bloodfeeding, and how key elements in sporozoite-vector relationships present new opportunities for tackling critical questions relevant for disease control.
Department of Immunology and Infectious Diseases, School of Hygiene and Public Health, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.
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