Schistosome surface antigens: developmental expression and immunological function.
It has long been held as axiomatic that antigens exposed on the surfaces of parasitic organisms are primary targets of protective immune responses. It is becoming apparent that not all protective schistosome antigens are surface antigens and that not all surface antigens are necessarily targets of protective immunity. Andy Simpson suggests that one of the factors that determines the immunological function of surface antigens may be developmental expression.
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
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