Tissue engineering with muscle-derived stem cells.
Tissue engineering and cell therapy approaches aim to take advantage of the repopulating ability and plasticity of multipotent stem cells to regenerate lost or diseased tissue. Researchers continue to investigate stem cells in mature tissues and demonstrate the potential ability of organ-specific cells to differentiate into multiple lineages. One stem cell that displays such promise is the muscle-derived stem cell (MDSC). Data supporting the existence of MDSCs have emerged as part of investigations to improve myoblast cell transplantation for the treatment of muscular dystrophies. As these efforts continue, the potential for MDSC-based therapy for other musculoskeletal injuries, as well as for cardiac and smooth muscle injuries, is currently being explored.
Bioengineering Department, University of Pittsburgh School of Medicine, PA 15260, USA.
Bridget M
BM
Deasy
Yong
Y
Li
Johnny
J
Huard
D000818:Animals; D001847:Bone Diseases / Q000628:therapy; D006331:Heart Diseases / Q000628:therapy; D006801:Humans; D009140:Musculoskeletal Diseases / Q000628:therapy; D032446:Myoblasts / Q000637:transplantation*; D033581:Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods; D014570:Urologic Diseases / Q000628:therapy