[Dendritic cells, natural killer cells and adhesion molecules in psoriasis].
OBJECTIVE
To study the role of the dendritic cells, natural killer cells and adhesion molecules play in the pathogenesis of psoriasis.


METHODS
The expression levels of human leukocyte antigen (HLA)-DR, CD1a, CD16, CD57, tumor necrosis factor (TNF)-alpha and intercellular adhesion molecule (ICAM)-1 were detected by immunohistochemistry in lesions of 26 patients with psoriasis before and after treatment.


RESULTS
The expression of HLA-DR, CD1a, CD16, CD57, TNF-alpha and ICAM-1 showed no significant difference between the active phase and the static phase of psoriatic lesions (P>0.05). After treatment, the positive expression of all markers decreased evidently or even disappeared with histopathological improvement in the resolvent phase of psoriatic lesions. There were statistically significant difference by Wilcoxon rank sum test (P<0.05).


CONCLUSIONS
Dendritic cells, natural killer cells and adhesion molecules play an important role in the pathogenesis of psoriasis.
Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Min
M
Zhang
Yi-zhi
YZ
Zhang
Sheng
S
Wang
Lin
L
Wang
Feng-yuan
FY
Li
D000328:Adult; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D011565:Psoriasis / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D012867:Skin / Q000276:immunology / Q000473:pathology
D006684:HLA-DR Antigens; D018799:Intercellular Adhesion Molecule-1