Enantioselective aldol reaction of trimethoxysilyl enol ether catalyzed by lithium binaphtholate.
[reaction: see text] An aldol reaction of trimethoxysilyl enol ether catalyzed by lithium binaphtholate, in which water serves as an additive and plays a pivotal role in stereoselectivities, was developed. This is the first example of an aldol reaction of trimethoxysilyl enol ether catalyzed by a chiral base.
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. nakajima@gpo.kumamoto-u.ac.jp
Makoto
M
Nakajima
Yuya
Y
Orito
Tadao
T
Ishizuka
Shunichi
S
Hashimoto