Genome sequence of a polydnavirus: insights into symbiotic virus evolution.
Little is known of the fate of viruses involved in long-term obligatory associations with eukaryotes. For example, many species of parasitoid wasps have symbiotic viruses to manipulate host defenses and to allow development of parasitoid larvae. The complete nucleotide sequence of the DNA enclosed in the virus particles injected by a parasitoid wasp revealed a complex organization, resembling a eukaryote genomic region more than a viral genome. Although endocellular symbiont genomes have undergone a dramatic loss of genes, the evolution of symbiotic viruses appears to be characterized by extensive duplication of virulence genes coding for truncated versions of cellular proteins.
Espagne
Eric
E
Institut de Recherche sur la Biologie de l'Insecte, CNRS UMR 6035, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France.
Dupuy
Catherine
C
Huguet
Elisabeth
E
Cattolico
Laurence
L
Provost
Bertille
B
Martins
Nathalie
N
Poirié
Marylène
M
Periquet
Georges
G
Drezen
Jean Michel
JM
D020816:Amino Acid Motifs; D000818:Animals; D017089:Ankyrin Repeat; D001482:Base Composition; D005075:Biological Evolution; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics; D005814:Genes, Viral; D016679:Genome, Viral; D007438:Introns; D018402:Manduca / Q000469:parasitology / Q000821:virology; D008969:Molecular Sequence Data; D018071:Polydnaviridae / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases / Q000235:genetics; D017422:Sequence Analysis, DNA; D013559:Symbiosis; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics; D014863:Wasps / Q000821:virology*
D015853:Cysteine Proteinase Inhibitors; D014764:Viral Proteins; D037521:Virulence Factors; D017027:Protein Tyrosine Phosphatases