Synthesis, structure and pharmacology of acyl-2,6-xylidines.
L-2-perhydroheterocyclicalkyl acids were condensed with 2,6-xylidine. 8 new optically active acyl-2,6-xylidines were obtained. Absolute configuration of acyl-2,6-xylidines were selected for pharmacological examinations.
Białasiewicz
Włodzimierz
W
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, Poland.
Kwapiszewski
Wincenty
W
Zurek
Elzbieta
E
Olczak
Andrzej
A
Główka
Marek
M
Polakowski
Rościsław
R
D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D018360:Crystallography, X-Ray; D005260:Female; D008012:Lidocaine / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D008297:Male; D051379:Mice; D011817:Rabbits; D013329:Structure-Activity Relationship; D016677:Tocainide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity
D000814:Aniline Compounds; D000889:Anti-Arrhythmia Agents; D016677:Tocainide; C007766:2,6-xylidine; D008012:Lidocaine