A new phenanthrene glycoside and other constituents from Dioscorea opposita.
Phytochemical investigation of the rhizome of Dioscorea opposita has led to the isolation of a new phenanthrene glycoside, 3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside (1), and five known compounds, soyacerebroside I (2), adenosine (3), beta-sitosterol (4), palmitic acid (5) and palmitoyloleoylphosphatidylcholine (6). Their structures were determined by spectroscopic methods, including 1D- and 2D-NMR. Compounds 1-6 exhibited no antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis.
Sautour
Marc
M
Laboratoire de Pharmacognosie, Unité UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.
Mitaine-Offer
Anne-Claire
AC
Miyamoto
Tomofumi
T
Wagner
Hildebert
H
Lacaille-Dubois
Marie-Aleth
MA
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D027742:Dioscorea; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts; D027343:Rhizome
C496664:3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside; D000935:Antifungal Agents; D006027:Glycosides; D010616:Phenanthrenes; D010936:Plant Extracts