[Safety assessment and effect of new-type drinking water on immunity in mice].
OBJECTIVE
To assess the safety of four kinds new-type drinking water and explore its effect on immunologic function in mice.


METHODS
Its acute oral toxicity and Genotoxicity were detected using acute toxicity test, Ames test, micronucleus assay of mice bone marrow cell and mice sperm malformation test. Its effects on cellular, humoral immune function were assessed respectively by metatarsus-thickening method, Jerne-improved slide method.


RESULTS
Its acute oral LD50 in mice were greater than 10000mg/kg BW, three genetic toxicity tests showed negative results, the metatarsal injected with SRBC and number of antibody forming cells were no evidently thicker in test group than in control group.


CONCLUSIONS
The result did not indicate the genotoxicity of the four kinds new-type drinking water and they couldn't effect immunologic function in mice.
Institute of Environment and Health Related Products Safety, China CDC, Beijing 100021, China.
Ruixia
R
Song
Shuxia
S
Xing
Xuetao
X
Bai
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D020552:Comet Assay; D005260:Female; D007109:Immunity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D023382:Toxicity Tests, Acute; D014881:Water Supply / Q000592:standards*