[Mice lacking PACAP: a mini-review focussing on brain function].
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal peptide (VIP)/ secretin/ glucagon superfamily and functions as a hormone, neurohormone, and neurotransmitter in the central nervous system as well as in several peripheral tissues. Recently, several groups including ours have independently produced lines of mice lacking PACAP (PACAP(-/-)). These mutant mice have not only led to a better understanding of the physiologic roles of endogenous PACAP, but have also revealed some unexpected roles of PACAP. In this paper, phenotypic changes in several brain functions in PACAP(-/-) mice, including light-induced phase-resetting of the circadian activity rhythm, hippocampal long-term potentiation, and psychomotor behaviors, are reviewed based on the results obtained in our laboratory.
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan. shintani@phs.osaka-u.ac.jp
Norihito
N
Shintani
D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000502:physiology*; D002940:Circadian Rhythm / Q000235:genetics; D017353:Gene Deletion; D006624:Hippocampus / Q000502:physiology; D017774:Long-Term Potentiation / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D009473:Neuronal Plasticity / Q000235:genetics; D009479:Neuropeptides / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011597:Psychomotor Performance
C495402:Adcyap1 protein, mouse; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide