Diterpenoids with inhibitory activity against NFAT transcription factor from Acanthopanax koreanum.
Six diterpenoids and two diterpene glycosides were isolated from the dichloromethane and the water fractions of Acanthopanax koreanum roots, respectively. Of these compounds, 16alphaH, 17-isovaleryloxy-ent-kauran-19-oic acid containing an isovaleryloxy group at C-17 was found to exhibit the strongest inhibitory activity (IC(50), 6.7 microm) against NFAT transcription factor. However, sumogaside, 16alpha-hydroxy-ent-kauran-19-oic acid and paniculosides IV containing a hydroxy group at C-16 or a glycoside at C-4 carboxyl acid showed no activity.
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Xing Fu
XF
Cai
Im Seon
IS
Lee
Nguyen Tien
NT
Dat
Guanghai
G
Shen
Young Ho
YH
Kim
D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D028001:Eleutherococcus; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014157:Transcription Factors / Q000037:antagonists & inhibitors*
D004224:Diterpenes; D010936:Plant Extracts; D018894:Reverse Transcriptase Inhibitors; D014157:Transcription Factors