[Calcium-dependent programmed cell death in prostate cancer].
In the present review we describe the major molecular determinants of calcium homeostasis in prostate cancer cells and establish their role in the transformation to apoptosis-resistant cell phenotypes typical of advanced androgen-independent prostate cancer. We show that the hallmark of such transformation is complete loss of apoptosis pathway associated with endoplasmic reticulum calcium store depletion.
Ia M
IaM
Shuba
N
N
Prevars'ka
R
R
Skryma
D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D002118:Calcium