Mapping a syntenic modifier on mouse chromosome 1 influencing the expressivity of the compact phenotype in the myostatin mutant (MstnCmpt-dl1Abc) compact mouse.
A novel method for mapping a modifier gene that is syntenic to its major gene was used to map a male-sex-limited modifier of the expressivity of the Compact phenotype in the myostatin mutant (Mstn(Cmpt-dl1Abc)) Compact mouse. The modifier was mapped to the general region of D1Mit262, 40 cM distal to Mstn on chromosome 1. Myogenin, a postulated downstream target of myostatin, maps to the same region.
Institute for Animal Biology, Agricultural Biotechnology Center, H-2101 Gödöllo, Hungary. varga@abc.hu
László
L
Varga
Orsolya
O
Pinke
Géza
G
Müller
Balázs
B
Kovács
Edit
E
Korom
Gyula
G
Szabó
Morris
M
Soller
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005809:Genes, Regulator; D005819:Genetic Markers; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018482:Muscle, Skeletal / Q000378:metabolism; D009154:Mutation; D018008:Myogenin / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype
D005819:Genetic Markers; C503801:Myog protein, mouse; D018008:Myogenin