Synthesis of AB diblock copolymers by atom-transfer radical polymerization (ATRP) and living polymerization of alpha-amino acid-N-carboxyanhydrides.
The synthesis of poly(methyl acrylate)-block-poly(gamma-benzyl-L-glutamate) (PMA-b-PBLG) diblock copolymers, using atom-transfer radical polymerization (ATRP) of methyl acrylate and living polymerization of gamma-benzyl-L-glutamate-N-carboxyanhydride (Glu-NCA) is described. Amido-amidate nickelacycle end groups were incorporated onto amino-terminated poly(methyl acrylates), and the resulting complexes were successfully used as macroinitiators for the growth of polypeptide segments. This method allows the controlled preparation of polypeptide-block-poly(methyl acrylate) diblock architectures with control over polypeptide chain length and without the formation of homopolypeptide contaminants.
Brzezinska
Krystyna R
KR
Materials Research Laboratory, Chemistry Department, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
Deming
Timothy J
TJ
D000596:Amino Acids / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis*; D011109:Polymethacrylic Acids / Q000737:chemistry*
D000596:Amino Acids; D000812:Anhydrides; D011108:Polymers; D011109:Polymethacrylic Acids; C003172:poly-gamma-benzyl-L-glutamate; C030613:polymethacrylic acid; D011099:Polyglutamic Acid