[In vitro antibacterial activity of cefdinir against isolates of respiratory tract pathogens in children].
OBJECTIVE
To study the in vitro antibacterial activity of cefdinir against clinical isolates of respiratory tract pathogens in Children.


METHODS
MIC values of cefdinir against 380 strains were determined with E-test method and compared with those of cefaclor.


RESULTS
All penicillin-susceptible Streptococcus pneumoniae (PSSP) strains were also susceptible to cefdinir and cefaclor. Both cefdinir and cefaclor were not active against penicillin-resistant SP (PRSP). Against penicillin-intermediate SP (PISP) the susceptibility rates of cefdinir and cefaclor were 70.1% and 57.4%, respectively. The activity of cefdinir and cefaclor against beta-lactamases negative Hemophilus influenzae (HI) was excellent, but the susceptibility rates of cefdinir and cefaclor against beta-lactamases positive HI were 85.0% and 70.0%, respectively with MIC(90) of 1.5 mg/L vs. 256.0 mg/L. Cefdinir presented higher activities and lower MIC values than cefaclor against Moraxella catarrhalis (MC), Group A streptococcus (GAS), methicillin susceptible staphylococcus aureus (MSSA), and extended spectrum beta-lactamases (ESBLs) negative Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pn). Both cefdinir and cefaclor were not susceptible to ESBLs positive E. coli and K. pn.


CONCLUSIONS
Cefdinir exhibits excellent activity against PSSP, PISP, HI, as well as MC, GAS, MSSA and ESBLs negative E. coli or K. pn.
Lu
Quan
Q
Shanghai Children's Hospital, Shanghai 200040, China.
Zhang
Hong
H
Che
Da-tian
DT
Li
Wan-hua
WH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D000077525:Cefdinir; D002511:Cephalosporins / Q000494:pharmacology*; D002648:Child; D006801:Humans; D008826:Microbial Sensitivity Tests; D012137:Respiratory System / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077525:Cefdinir