[A new synthesis of alpha-methylspermidine].
A five-step synthesis of alpha-methylspermidine (1,8-diamino-5-azanonane), the first polyamine analogue preventing pathological consequences of spermidine depletion in transgenic rats overproducing spermine/spermidine N'-acetyltransferase, from ethyl 3-aminobutyrate was achieved in a high overall yield.
Grigorenko
N A
NA
Vepsalainen
J
J
Jarvinen
A
A
Keinanen
T A
TA
Alhonen
L
L
Janne
J
J
Kritsyn
A M
AM
Khomutov
A R
AR
D000818:Animals; D030801:Animals, Genetically Modified; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051381:Rats; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
C073193:1-methylspermidine; D013095:Spermidine