Comparison of coenzyme Q10 plasma levels in obese and normal weight children.
BACKGROUND
Childhood obesity is associated with lower plasma levels of lipophilic antioxidants which may contribute to a deficient protection of low-density lipoproteins (LDL). An increased plasma level of oxidized LDL in obese people with insulin resistance has been demonstrated. The lipophilic antioxidant coenzyme Q10 (CoQ10) is known as an effective inhibitor of oxidative damage in LDL as well. The aim of the present study was to compare the CoQ10 levels in obese and normal weight children.


METHODS
The CoQ10 plasma concentrations were measured in 67 obese children (BMI>97th percentile) and related to their degree of insulin resistance. Homeostasis model assessment (HOMA) was used to detect the degree of insulin resistance. The results were compared to a control group of 50 normal weight and apparently healthy children. The results of the CoQ10 levels were related to the plasma cholesterol concentrations.


RESULTS
After adjustment to plasma cholesterol, no significant difference in the CoQ10 levels between obese and normal weight children could be demonstrated. Furthermore, there was no difference between insulin-resistant and non-insulin-resistant obese children.


CONCLUSIONS
CoQ10 plasma levels are not reduced in obese children and are not related to insulin resistance.
Menke
Thomas
T
Vestische Kinderklinik Datteln, Universität Witten/Herdecke, Dr.-Friedrich-Steiner-Str. 5, D-45711 Datteln, Germany. th.menke@t-online.de
Niklowitz
Petra
P
de Sousa
Gideon
G
Reinehr
Thomas
T
Andler
Werner
W
D000293:Adolescent; D001835:Body Weight; D002648:Child; D002784:Cholesterol / Q000097:blood; D003067:Coenzymes; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology; D012016:Reference Values; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood*
D003067:Coenzymes; D008077:Lipoproteins, LDL; D014451:Ubiquinone; D002784:Cholesterol; C024989:coenzyme Q10