Autologous human fibrin as the biomaterial for tissue engineering.
Patient own fibrin may act as the safest, cheapest and immediate available biodegradable scaffold material in clinical 1 tissue engineering. This study investigated the feasibility of using patient own fibrin isolated from whole blood to construct a new human cartilage, skin and bone. Constructed in vitro tissues were implanted on the dorsal part of the nude mice for in vivo maturation. After 8 weeks of implantation, the engineered tissues were removed for histological analysis. Our results demonstrated autologous fibrin has great potential as clinical scaffold material to construct various human tissues.
Ruszymah
B H I
BH
Department of Physiology, Medical Faculty of Universiti Kebangsaan Malaysia.
D000818:Animals; D001672:Biocompatible Materials; D016025:Bone Transplantation; D002356:Cartilage / Q000637:transplantation*; D002455:Cell Division / Q000502:physiology; D003470:Culture Media; D005337:Fibrin; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051379:Mice; D008819:Mice, Nude; D009924:Organ Culture Techniques; D010521:Periosteum / Q000166:cytology; D016038:Skin Transplantation; D023822:Tissue Engineering
D001672:Biocompatible Materials; D003470:Culture Media; D005337:Fibrin