Raising high-density lipoprotein cholesterol with inhibitors of cholesteryl ester transfer protein - a new approach to coronary artery disease.
Although the low-density lipoprotein (LDL) cholesterol-lowering statins reduce the mortality and morbidity associated with coronary artery disease, considerable mortality and morbidity remains. Increasing high-density lipoprotein (HDL) cholesterol reduces coronary artery disease mortality and morbidity. In healthy subjects with mild dyslipidaemia, treatment with JTT-705 decreased cholesteryl ester transfer protein (CETP) activity, increased HDL-cholesterol and decreased LDL-cholesterol. Similarly, another CETP inhibitor, torcetrapib 120 mg/day has recently been shown to increase HDL-cholesterol by 46%, decrease LDL-cholesterol by 8% and have no effect on triglycerides in subjects with HDL-cholesterol < 1 mmol/l. In subjects treated with atorvastatin to lower their LDL-cholesterol levels, torcetrapib further lowered LDL-cholesterol while increasing HDL-cholesterol. In conclusion, raising HDL-cholesterol with inhibitors of CETP is a new approach to coronary artery disease that requires further investigation, especially in patients with coronary artery disease.
Doggrell
Sheila A
SA
Doggrell Biomedical Communications, 47 Caronia Crescent, Lynfield, Auckland, New Zealand. s.doggrell@xtra.com
D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism; D002986:Clinical Trials as Topic; D002995:Clofibric Acid / Q000494:pharmacology / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000188:drug therapy*; D006023:Glycoproteins / Q000037:antagonists & inhibitors*; D006801:Humans; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use*
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006023:Glycoproteins; D011804:Quinolines; C483909:torcetrapib; D002995:Clofibric Acid