Brasilicardins B-D, new tricyclic terpenoids [correction of terpernoids] from actinomycete Nocardia brasiliensis.
Three new tricyclic terpenoids, brasilicardins B-D (2-4), were isolated together with brasilicardin A (1), a potent immunosuppressive compound, from the cultured broth of a pathogenic actinomycete Nocardia brasiliensis IFM0406, and the structures and stereochemistry were determined by spectroscopic data and a single crystal X-ray diffraction analysis. The immunosuppressive and cytotoxic activities of 2-4 were examined in the comparison with 1.
Komatsu
Kazusei
K
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Tsuda
Masashi
M
Shiro
Motoo
M
Tanaka
Yasushi
Y
Mikami
Yuzuru
Y
Kobayashi
Jun'ichi
J
D000617:Aminoglycosides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D003500:Cyclization; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009615:Nocardia / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D000617:Aminoglycosides; D003603:Cytotoxins; D007166:Immunosuppressive Agents; D013729:Terpenes; C118259:brasilicardin A