A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache.
Several polymorphisms of the hypocretin/orexin system genes were evaluated in 109 cluster headache patients and 211 controls. The 1246 G>A polymorphism of the gene was significantly different between cases and controls. Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.
Rainero
I
I
Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15-10126 Turin, Italy. irainero@molinette.piemonte.it
Gallone
S
S
Valfrè
W
W
Ferrero
M
M
Angilella
G
G
Rivoiro
C
C
Rubino
E
E
De Martino
P
P
Savi
L
L
Ferrone
M
M
Pinessi
L
L
D000328:Adult; D016022:Case-Control Studies; D003027:Cluster Headache / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D064446:Orexin Receptors; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide / Q000235:genetics*
D064446:Orexin Receptors; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide