[Heterosexual precocious puberty due to arrhenoblastoma. Postsurgical spontaneous pregnancy].
It is presented the case of a female with heterosexual precocious puberty associated to hyperandrogenism and virilization due to arrhenoblastoma, who became pregnant after surgery. Clinical study: a 14-year-old female initiated at age 6 years with premature pubarche and telarche. By age 11, the patient only had one menstrual period along with virilization. Physical exam disclosed: facial acne, cricoid enlargement, breast Tanner II, pubic hair Tanner III, clitoromegaly of 4.5 cm and hypotrophy of labia majora. Ferriman and Gallwey: 12. Basal quantitation of circulating testosterone: 1.25 ng/mL (normal: 0.2 to 0.8 ng/mL), androstenedione 13.9 ng/mL (normal: 0.5 to 2.4 ng/mL). A pelvic ultrasonographic study showed: uterus of 66 x 25 x 30 mm, right ovary of 50 x 50 mm, hyperechoic with echolucid and nodular areas (vol. 65.3 cc). Left ovary was of 30 x 30 mm with echolucid areas of 2.0 mm (vol. 5.1 cc). Cariotype: 46XX. Surgical right oophorectomy was performed containing an ovoid tumor of 4 x 3 x 3 cm. Histologic analysis revealed a Sertoli Leydig (Type II, Mayoer) cell tumor. The patient resumed menses and became pregnant at age 20 (22 week obitus). In the last assessment, performed 6 years after surgery, the patient resumed normal menses, Ferriman and Gallwey 5, Tanner V and regression of clitoromegaly to 3.0 cm. In this case, surgery provided remission of hyperandrogenism, normal menstrual cycles and fertility restoration.
Málaga Correa
Yanet R
YR
Departamento de biología de la reproducción humana, Hospital Juárez de México, SSA.
Tovar Rodríguez
José María
JM
Hernández Marín
Imelda
I
Ayala
Aquiles R
AR
D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications / Q000601:surgery*; D011247:Pregnancy; D011629:Puberty, Precocious / Q000209:etiology*; D018310:Sertoli-Leydig Cell Tumor / Q000150:complications / Q000601:surgery*