Self-assembly of human serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) microcapsules for controlled drug release.
Human serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) were applied as a pair to encapsulate ibuprofen microcrystals by means of a technique based on the layer-by-layer (LbL) assembly of oppositely charged species, for the purpose of controlling drug release. The successful adsorption of HSA and DMPA multilayers onto ibuprofen crystals was confirmed by optical microscopy. The drug release process, in a solution of pH 7.4, was monitored by optical microscopy and UV spectroscopy. The results revealed that the rate of release of ibuprofen from HSA/DMPA microcapsules decreased as the capsule wall thickness and drug crystal size increased, indicating that the permeability of the microcapsules can be controlled by simply varying the number of HSA/DMPA deposition cycles.
International Joint Lab, Key Laboratory of Colloid and Interface Science, The Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Zhihua
Z
An
Gang
G
Lu
Helmuth
H
Möhwald
Junbai
J
Li
D002214:Capsules / Q000737:chemistry; D003460:Crystallization; D016503:Drug Delivery Systems; D020404:Glycerophospholipids / Q000737:chemistry*; D006801:Humans; D007052:Ibuprofen / Q000737:chemistry; D008863:Microspheres; D008958:Models, Molecular; D010539:Permeability; D017434:Protein Structure, Tertiary; D012709:Serum Albumin / Q000737:chemistry*
D002214:Capsules; D020404:Glycerophospholipids; D012709:Serum Albumin; C025602:dimyristoylphosphatidic acid; D007052:Ibuprofen