An investigation into causes and effects of high cyanide levels in the palladium-catalyzed cyanation reaction.
[reaction: see text] The palladium-catalyzed cyanation reaction is known to be sensitive to dissolved cyanide. Investigation into some causes of high levels of dissolved cyanide is presented here, along with a robust solution to this problem.
Marcantonio
Karen M
KM
Department of Process Research, Merck Research Laboratories, P.O. Box 2000 Rahway, New Jersey 07065, USA. karen_marcantonio@merck.com
Frey
Lisa F
LF
Liu
Yong
Y
Chen
Yadan
Y
Strine
Jeff
J
Phenix
Brian
B
Wallace
Debra J
DJ
Chen
Cheng-yi
CY
D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D003486:Cyanides; D010165:Palladium