[The effect of acetylcholine, dopamine, histamine and serotonin in the tracheal smooth muscle in the response with desquamative and non-desquamative epithelium of respiratory pathways in vitro].
In this paper we have examined the receptor bronchial system in newly born children with desquamative and with preserved epithelium of aerial pathways. The response was followed in: acetylcholine, dopamine, histamine and scrotonin in various concentrations (10(-4), 10(-3), 10(-2), 10(-1)). The tonus of the tracheal smooth muscle was examined in 29 tracheal preparations, taken by autopsy after excitation from various factors. On the basis of functional investigation it has been established as follows: acetylcholine had caused the response of the bronchial smooth muscle with desquamative epithelium in a significant way (p < 0.01), in contrast to cases which were treated with unimpaired epithelium (p > 0.1). The effect of dopamine was significant in cases with desquamative epithelium (p < 0.05), in contrast to cases where epithelium was preserved (p > 0.1). The effect of histamine was also significant in cases with desquamative epithelium of respiratory pathways (p < 0.01), in contrast to cases where epithelium was preserved. Cases with desquamative epithelium in serotonin have reacted significantly (p < 0.01), despite cases which had no impaired epithelium of respiratory pathways (p > 0.1). Obtained results show that the response of the tracheal discs with desquamative epithelium of respiratory pathways was significant (p < 0.01), despite cases which had preserved the epithelium of respiratory pathways (p > 0.1). This suggest that various mediators with local effect are released during desquamation of epithelium which increase thus the bronchial reactibility of respiratory pathways.
Katedra za Farmaciju, Medicinski Fakultet, Prishtina, R Makedonija.
Hilmi
H
Islami
B
B
Kastrati
R
R
Shabani
M
M
Disha
D000109:Acetylcholine / Q000494:pharmacology; D046508:Culture Techniques; D004298:Dopamine / Q000494:pharmacology; D005333:Fetus / Q000166:cytology / Q000502:physiology; D005865:Gestational Age; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007231:Infant, Newborn; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D011950:Receptors, Cholinergic / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D020545:Respiratory Mucosa / Q000166:cytology / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D006632:Histamine; D000109:Acetylcholine; D004298:Dopamine