Zinc status and bone mineralisation in adolescent girls.
The aim of the project was to assess the relationship between zinc status and bone mineralisation in pre-menarcheal adolescent girls. One hundred and thirty-nine healthy pre-menarcheal girls (Tanner pubic hair stage < or = 4), aged 12.4 +/- 1.0 years, had two visits at an interval of 2 years. Serum and urine zinc concentrations (Zn S; Zn U; Zn U/ creatinine), insulin-like growth factor 1 (IGF-I), and markers of bone turn-over, i.e. osteocalcin and parathormone (PTH), concentrations were measured at the first visit. Lumbar (L2-L4) bone mineral content and density (BMC, BMD) were measured at both visits. BMC and BMD and their increase at the follow-up after 2 years were compared with biochemical data by multiple regression. The stage of puberty was added as a covariable in the analysis. At the first visit, a significant correlation was found between sexual maturity and initial BMC, BMD, height, weight, and IGF-I. Zn S was negatively correlated with osteocalcin. Zn U showed a positive correlation with BMC, BMD, IGF-I, height, weight, and PTH. At the second visit, sexual maturity showed a positive correlation with BMD and weight increments and a negative one with BMC and height gains. Zn S was significantly related with BMD increase. These correlations suggest that zinc plays a role in normal growth and bone mineralisation during puberty onset.
Laboratoire de Physiologie et Service de Pédiatrie A, CHU de Caen, Avenue Georges Clémenceau, F-14033 Caen Cedex, France. bougle-d@chu-caen.fr
Dominique L
DL
Bouglé
Jean-Pierre
JP
Sabatier
Geneviève
G
Guaydier-Souquières
Françoise
F
Guillon-Metz
Dominique
D
Laroche
Philippe
P
Jauzac
François
F
Bureau
D000293:Adolescent; D000818:Animals; D015415:Biomarkers; D015519:Bone Density; D002113:Calcification, Physiologic / Q000502:physiology*; D005260:Female; D006801:Humans; D012044:Regression Analysis; D012741:Sexual Maturation / Q000502:physiology; D015032:Zinc / Q000097:blood* / Q000652:urine*
D015415:Biomarkers; D015032:Zinc