Transfer of celecoxib into human milk.
The aim of this study was to investigate the transfer of celecoxib into human milk. In one group of 3 breastfeeding patients on celecoxib at steady state, milk levels were determined at set intervals over 24 hours. Plasma levels were determined in 2 of their infants, age 17 and 22 months. In a second group of 2 subjects, intravenous lines were placed and a single 200-mg dose of celecoxib was followed by multiple paired plasma and milk samples over 8 hours. The mean milk-to-plasma ratio for celecoxib was 0.23 (95% confidence interval [CI]: 0.15-0.31). The average concentration of celecoxib in milk during the 8-hour dosing interval was 66 microg/L (95% CI: 41-89). The absolute infant dose averaged 9.8 microg/kg/d (95% CI: 6.2-13.4); the mean relative infant dose was 0.30%. Therefore, the average clinical dose transferred to the infant daily would be approximately 0.3% of the weight-adjusted maternal dose. The authors suggest that the use of celecoxib in breastfeeding mothers at these doses is very unlikely to cause untoward effects in breastfed infants.
Department of Pediatrics, Texas Tech University School of Medicine, Amarillo, TX, USA.
Thomas W
TW
Hale
Rose
R
McDonald
James
J
Boger
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001942:Breast Feeding; D000068579:Celecoxib; D005260:Female; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007774:Lactation / Q000378:metabolism*; D008895:Milk, Human / Q000737:chemistry* / Q000378:metabolism; D011720:Pyrazoles / Q000097:blood / Q000493:pharmacokinetics*; D013449:Sulfonamides / Q000097:blood / Q000493:pharmacokinetics*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib