What is the role of high-frequency ventilation in adult respiratory distress syndrome?
The goal of positive-pressure mechanical ventilation is to provide respiratory support to a patient while allowing the underlying diseased lungs to heal. Research using both animal models and humans suggests that positive-pressure ventilation can injure the lung through both overdistension and under recruitment. Theoretically,the ultimate lung-protective strategy would consist of very small tidal volumes to avoid pressure swings while maintaining alveolar recruitment. High-frequency ventilation provides such a strategy of mechanical ventilation. This article examines the utility of using high-frequency modes of mechanical ventilation in supporting the patient with ARDS.
Division of Pulmonary, Allergy, and Critical Care and the Department of Anesthesia, Duke University Medical Center, Box 3221, Durham, NC 27710, USA. bartz001@mc.duke.edu
Raquel R
RR
Bartz
D000818:Animals; D006612:High-Frequency Ventilation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D011175:Positive-Pressure Respiration / Q000009:adverse effects* / Q000379:methods; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000401:mortality / Q000517:prevention & control / Q000628:therapy*; D013990:Tidal Volume / Q000502:physiology