Molecular detection of minimal residual disease is associated with early relapse in adult acute lymphoblastic leukemia.
Several studies in childhood acute lymphoblastic leukemia (ALL) have documented that molecular detection of minimal residual disease (MRD) based on screening for T-cell receptor and immunoglobulin gene rearrangements can identify patients at a high risk of relapse. In our experience, evaluation of MRD in adult ALL can help to identify high risk patients.
Specchia
Giorgina
G
Liso
Arcangelo
A
Pannunzio
Alessandra
A
Albano
Francesco
F
Mestice
Anna
A
Pastore
Domenico
D
Liso
Vincenzo
V
D000293:Adolescent; D000328:Adult; D001856:Bone Marrow Examination; D004273:DNA, Neoplasm / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000401:mortality / Q000473:pathology; D017254:Leukemic Infiltration; D008297:Male; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D018365:Neoplasm, Residual; D016133:Polymerase Chain Reaction; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000401:mortality / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D012074:Remission Induction; D015203:Reproducibility of Results; D016019:Survival Analysis
D004273:DNA, Neoplasm; D007145:Immunoglobulin kappa-Chains; D009363:Neoplasm Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta