[Results of midodrin treatment of vasovagal syncope].
OBJECTIVE
To elicit efficacy of midodrin in patients with vasovagal syncope.


METHODS
50 patients with recurrent vasovagal syncope documented by head-up tilt tests or bicycle exercise stress tests participated in the study. These tests controlled the effects of midodrin if syncopes occurred again in repetition of the tests. In the other patients the effect of the drug was assessed clinically. All the patients received midodrin in daily dose up to 15 mg.


RESULTS
Mirodrin effectively prevented syncope in 13 (72%) patients as shown by the tilt test, in 10 (59%) patients as shown by the exercise stress tests and in 14 (93%) patients as controlled clinically. Total efficacy of midodrin was 74% (37 of 50 patients).


CONCLUSIONS
Midodrin demonstrated high efficacy in prevention of vasovagal syncope. Side effects were not serious therefore the drug is well tolerated.
Kuchinskaia
E A
EA
Pevzner
A V
AV
Vershuta
E V
EV
Al'bitskaia
K V
KV
Kheĭmets
G I
GI
Rogoza
A N
AN
Golitsyn
S P
SP
D000293:Adolescent; D000328:Adult; D000368:Aged; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008879:Midodrine / Q000009:adverse effects / Q000627:therapeutic use*; D019462:Syncope, Vasovagal / Q000517:prevention & control*
D008879:Midodrine