Approaches for trigger-inducible viral transgene regulation in gene-based tissue engineering.
Recent advances in mammalian transgene expression dosing have resulted in a portfolio of mutually compatible systems that can adjust therapeutic transgene levels in response to antibiotics, hormone analogues, quorum-sensing messengers and secondary metabolites. The molecular merger of trigger-inducible expression technology with the latest generation of virus-derived transduction systems has enabled unmatched clinical interventions to shape desired therapeutic cell and tissue phenotypes for the treatment of complex human diseases.
Weber
Wilfried
W
Institute of Biotechnology, Swiss Federal Institute of Technology, ETH Hoenggerberg, CH-8093 Zurich.
Fussenegger
Martin
M
D000818:Animals; D005786:Gene Expression Regulation; D005814:Genes, Viral; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000627:therapeutic use*; D006801:Humans; D012107:Research Design; D023822:Tissue Engineering / Q000379:methods / Q000639:trends; D019076:Transgenes / Q000235:genetics*