Synthesis and antitumor activity of bicyclo[3.3.1]nonenol derivatives.
Various novel bicyclo[3.3.1.]nonenol derivatives were synthesized in an efficient one-pot procedure in a remarkably stereoselective reaction. The title compounds show significant antitumor activity against human cancer cell lines. A variety of cinnamic acid derivatives were linked to the title compounds as side chains in order to enhance the antitumor activity. These compounds were subjected to the in vitro antitumor screening, and the results are discussed. It seems important with respect to antitumor activity to locate an aromatic ring at the C-7 position of the bicyclo[3.3.1]nonane framework.
Science Institute, University of Iceland, Dunhaga 3, IS-107 Reykjavik, Iceland. jkfg@raunvis.hi.is
Jon K F
JK
Geirsson
Stefan
S
Jonsson
Jon
J
Valgeirsson
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans
D000970:Antineoplastic Agents; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; C458301:bicyclo(3.3.1)nonane