The effects of autologous human serum on the growth of tissue engineered human articular cartilage.
Culture media supplemented with animal serum e.g. fetal bovine serum; FBS is commonly used for human culture expansion. However, for clinical application, FBS is restricted as its carry a risk of viral or prion transmission. Engineering autologous cartilage with autologous human serum supplementation is seen as a better solution to reduce the risk of transmitting infectious diseases and immune rejection during cartilage transplantation. The purpose of this study is to establish and compare the effects of 10% autologous human serum (AHS) and 10% FBS on the growth of chondrocytes and the formation of tissue engineered human articular cartilage.
Badrul
A H M Y
AH
Department of Orthopaedics & Traumatology, Faculty of Medicine, UKM, Malaysia.
Aminuddin
B S
BS
Sharaf
I
I
Samsudin
O C
OC
Munirah
S
S
Ruszymah
B H I
BH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002358:Cartilage, Articular / Q000254:growth & development / Q000637:transplantation*; D002452:Cell Count; D002455:Cell Division / Q000502:physiology; D002648:Child; D019902:Chondrocytes / Q000166:cytology*; D003470:Culture Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044967:Serum; D023822:Tissue Engineering
D003470:Culture Media