[Toxic liver injuries].
Drug induced hepatotoxicity is clinically important for several reasons. These forms of liver injury can mimic almost all other liver diseases, making it necessary to include them into the differential diagnosis in patients with unclear liver damage. The diagnosis must be made indirectly, by judging the temporal relationship with therapy and by exclusion of other liver diseases. Re-exposure is dangerous should be avoided. Knowledge of the most important risk factors is important for avoiding drug-induced liver injury. Since there is no specific therapy for most drug-induced liver injuries, early stopping of the administration of suspected drugs is very important.
Klinik für Pharmakologie und Toxikologie, Universitätsspital Basel, Schweiz. kraehenbuehl@uhbs.ch
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D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000473:pathology; D008297:Male; D012307:Risk Factors