Efficacy of E2-sub-unit marker and C-strain vaccines in reducing horizontal transmission of classical swine fever virus in weaner pigs.
At present, two types of vaccines against classical swine fever (CSF) virus are commercially available: E2 sub-unit marker vaccines and the conventional attenuated live C-strain vaccines. To evaluate the reduction of the horizontal virus transmission, three comparable experiments were carried out in which groups of weaner pigs (vaccinated with a marker vaccine or a C-strain vaccine) were challenged with CSF virus at 0, 7, and 14 days post-vaccination (dpv). Virus transmission was prevented totally when the challenge occurred at 14 dpv with an E2-marker vaccine (0/12 contact pigs positive in virus isolation (VI); R = 0 (0; 1.5)). At 7 dpv, transmission was reduced slightly (5/12 contact pigs positive in VI; R = 1.0 (0.3; 3.0)), whereas at 0dpv, vaccination had no effect on transmission (10/12 contact pigs positive in VI; R = 2.9 (1.5; 10.8)). In the C-strain-vaccinated pigs, no virus transmission was detected even when the challenge was performed at the same day as the vaccination (0/12 contact pigs positive in VI; R = 0 (0; 1.5)).
Department of Reproduction, Obstetrics and Herd Health, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. jeroen.dewulf@ugent.be
J
J
Dewulf
H
H
Laevens
F
F
Koenen
K
K
Mintiens
A
A
de Kruif
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D006691:Classical Swine Fever / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006692:Classical Swine Fever Virus / Q000235:genetics / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005819:Genetic Markers; D007962:Leukocytes / Q000821:virology; D008297:Male; D013552:Swine; D014611:Vaccination / Q000662:veterinary; D022581:Vaccines, Marker; D014759:Viral Envelope Proteins; D014765:Viral Vaccines; D014886:Weaning
D000914:Antibodies, Viral; D005819:Genetic Markers; D022581:Vaccines, Marker; D014759:Viral Envelope Proteins; D014765:Viral Vaccines; C087086:glycoprotein E2, classical swine fever virus