Evaluation of tests based on the antibody response to keyhole limpet haemocyanin and soluble egg antigen to differentiate acute and chronic human schistosomiasis mansoni.
Specific IgG and IgM responses to soluble egg antigen (SEA) and keyhole limpet haemocyanin (KLH) were measured by ELISA in patients with acute and chronic schistosomiasis. The tests based upon IgM and IgG antibodies responses to KLH presented the best diagnostic discrimination, and can be used in conjunction with clinical and epidemiological data to the differential diagnosis of acute schistosomiasis.
Beck
Lílian
L
Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.
Van-Lüme
Daniele S M
DS
Souza
Joelma R de
JR
Morais
Clarice N Lins de
CN
Melo
Wlademir G
WG
Xavier
Edeneide
E
Barbosa
Constança S
CS
Aroucha
Marcílio L
ML
Domingues
Ana Lúcia C
AL
Favre
Tereza
T
Pieri
Otávio
O
Abath
Frederico G C
FG
Montenegro
Silvia M L
SM
D000208:Acute Disease; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D000947:Antigens, Helminth / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D015801:Helminth Proteins / Q000097:blood*; D006433:Hemocyanins / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015415:Biomarkers; D015801:Helminth Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C055560:p40 egg antigen, Schistosoma; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin