Familial primary mediastinal nonseminomatous germ-cell tumors.
In this article, we describe the case of 4 brothers, 2 of which had primary mediastinal nonseminomatous germ cell tumors (PMNSGCT), while the other 2 had benign mediastinal disease. We discuss the relationship between these diseases of the mediastinum and the thymic microenvironment. Additionally, we suggest that a genetic predisposition for germ-cell tumors (GCT) may be involved since the parents were relatives.
Marti
Adina
A
Institut Gustave Roussy, Villejuif, France.
Culine
Stéphane
S
Carde
Patrice
P
Paugam
Bertrand
B
Fizazi
Karim
K
D000293:Adolescent; D000328:Adult; D003241:Consanguinity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008477:Mediastinal Diseases / Q000235:genetics* / Q000473:pathology*; D008479:Mediastinal Neoplasms / Q000235:genetics* / Q000473:pathology*; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics* / Q000473:pathology*; D010375:Pedigree; D035781:Siblings