Oocyte quality in patients with severe ovarian hyperstimulation syndrome: a self-controlled clinical study.
OBJECTIVE
To investigate the oocyte quality in patients with severe ovarian hyperstimulation syndrome (OHSS).


METHODS
Self-controlled clinical study.


METHODS
University teaching hospital.


METHODS
Twenty-two patients from our assisted reproductive technology (ART) program who developed severe OHSS during their first controlled ovarian hyperstimulation for IVF or intracytoplasmic sperm injection (ICSI) (OHSS cycles) during a period of 10 years and had a second ART attempt performed in our center in which OHSS did not develop (control cycles).


METHODS
IVF and ICSI.


METHODS
Oocyte yield and quality, fertilization rate, embryo yield and quality, implantation rate, and pregnancy rate.


RESULTS
The total number of oocytes retrieved and the mean number of metaphase II oocytes were significantly higher in patients with OHSS than in control cycles. Fertilization rates were similar in both groups of ART cycles, and thus the number of viable embryos were significantly higher in OHSS cycles. Implantation and pregnancy rates were similar in OHSS and control cycles. Oocyte and embryo yield and quality were similar in early and late OHSS. Oocyte yield and quality, embryological outcome, and implantation and pregnancy rates were similar in patients with and without polycystic ovarian syndrome (PCOS) both in cycles developing OHSS and control cycles.


CONCLUSIONS
Oocyte quality is not compromised in severe OHSS cycles irrespective of whether patients had or did not have PCOS.
Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Francisco
F
Fábregues
Joana
J
Peñarrubia
Ester
E
Vidal
Gemma
G
Casals
Juan A
JA
Vanrell
Juan
J
Balasch
D000328:Adult; D010064:Embryo Implantation / Q000502:physiology*; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007246:Infertility / Q000473:pathology / Q000628:therapy*; D008297:Male; D009865:Oocytes / Q000502:physiology*; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000473:pathology* / Q000628:therapy; D011085:Polycystic Ovary Syndrome / Q000473:pathology; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects / Q000379:methods*
D004958:Estradiol