Gastrointestinal stromal tumor of the stomach with rhabdoid phenotype: immunohistochemical, ultrastructural, and immunoelectron microscopic evaluation.
A variety of neoplasms with rhabdoid differentiation have been reported in many sites. The authors describe a case of gastrointestinal stromal tumor (GIST) of the stomach that exhibited prominent rhabdoid features. Immunohistochemically, the tumor cells displayed positive staining for vimentin, c-kit, CD34, and alpha smooth muscle actin. Ultrastructural examination of the rhabdoid tumor cells revealed paranuclear whorls of intermediate filaments, which were immunoreactive for vimentin by both light microscopic immunohistochemical and protein A gold immunoelectron microscopic techniques. On H&E light microscopic examination alone, such a tumor could be mistaken for a variety of epithelial, mesenchymal, or other neoplasms that may show rhabdoid features. One report of GIST with a rhabdoid histologic phenotype has been described. This is the second known report of such a case with immunophenotypic and ultrastructural evaluation, and the first case with immunoelectron microscopic examination.
Richmond
Jeffrey A
JA
University of Vermont College of Medicine, Fletcher Allen Health Care, Department of Pathology, Burlington, Vermont 05401, USA. jeffrey.richmond@vtmednet.org
Mount
Sharon L
SL
Schwarz
Janet E
JE
D000199:Actins / Q000032:analysis; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D017809:Fatal Outcome; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000648:ultrastructure; D008297:Male; D046529:Microscopy, Electron, Transmission; D010641:Phenotype; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis
D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D014746:Vimentin; D019009:Proto-Oncogene Proteins c-kit