Lysophospholipid acyltransferases in monocyte inflammatory responses and sepsis.
Acyltransferases are important in the regulation of membrane phospholipid fatty acyl composition and together with phospholipase A2 enzymes control arachidonic acid incorporation and remodelling within phospholipids. In addition, monocyte and macrophage acyltransferase activity has been shown to respond to various inflammatory cytokines under conditions that can induce enhanced cellular responses. Work in our laboratory indicates that the enzyme lysophosphatidylcholine acyltransferase may mediate the priming reactions of monocytes to the cytokine interferon-gamma. Our recent studies suggest that this enzyme might also affect the responses of monocytes to the bacterial agent lipopolysaccharide that may be important in the development of sepsis. This article summarises the relationship between monocyte lysophosphatidylcholine acyltransferase, lipopolysaccharide and sepsis.
Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK. jacksonsk@cf.ac.uk
Simon K
SK
Jackson
Joan
J
Parton
D008243:1-Acylglycerophosphocholine O-Acyltransferase / Q000378:metabolism*; D007249:Inflammation / Q000276:immunology; D015850:Interleukin-6 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D009000:Monocytes / Q000201:enzymology / Q000276:immunology*; D018805:Sepsis / Q000201:enzymology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015854:Up-Regulation
D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D008243:1-Acylglycerophosphocholine O-Acyltransferase