The role of Dectin-1 in antifungal immunity.
beta-Glucans are structural components of fungal cell walls, which have a stimulatory effect on the immune system. Although a number of receptors for these carbohydrates have been proposed, the recently identified C-type lectin-like receptor, Dectin-1, appears to play a central role. Dectin-1 is expressed on phagocytic cells, including macrophages and neutrophils, and mediates both the internalization and cellular responses to beta-glucan, through unique mechanisms. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule, although its function in these responses is less clear. This review will highlight the current knowledge of Dectin-1 and its potential role in antifungal immunity, as well as deficiencies in our understanding.
Sir William Dunn School of Pathology, University of Oxford, UK.
Jurgen
J
Herre
Janet A
JA
Willment
Siamon
S
Gordon
Gordon D
GD
Brown
D000818:Animals; D005658:Fungi / Q000276:immunology*; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000276:immunology; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D008954:Models, Biological; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D010587:Phagocytosis / Q000276:immunology; D011971:Receptors, Immunologic / Q000378:metabolism / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D047071:beta-Glucans / Q000276:immunology / Q000378:metabolism; D000099181:Dectin-1
D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D047071:beta-Glucans; D000099181:Dectin-1