[Largest extension of CO2 laser surgery for laryngeal cancer in experimental animals].
OBJECTIVE
To explore the security and limit resection extension of CO2 laser surgery for laryngeal cancer in experimental animal under self-retaining laryngoscope.


METHODS
Ten experimental dogs were selected and received CO2 laser surgery with self-retaining laryngoscope. Vertical partial or supraglottic horizontal laryngectomy was performed according to the surgical criteria. All the dogs were killed immediately (5/10) or 40 days later(5/10) by using air embolus postoperatively. The whole larynx was taken out, and specimens were embedded with colloidion and then serially sectioned. Dimension of excision and wound surface recovery status were observed.


RESULTS
All the operations on experiment animals were successful and the results were satisfactory. The excision dimension was the same as standard surgery. Gross specimens and serial sectioning staining of 5 dogs were performed. And the other 5 dogs wound surface had already recovered.


CONCLUSIONS
CO2 laser surgery was comparable with traditional vertical partial laryngectomy and supraglottic horizontal laryngectomy for excision size. Animals were able to survive the surgery, wound surface could recover spontaneously. It suggested the possibility of extended laryngectomy with laser.
Department of Otorhinolarynology Head and Neck Surgery, Beijing Tongren Hospital, Affiliated to Capital University of Medical Sciences, Beijing 100730, China. enthzg@trhos.com
Zhi-Gang
ZG
Huang
De-Min
DM
Han
Zhen-Kun
ZK
Yu
Xin
X
Ni
Xiao-Hong
XH
Chen
D000818:Animals; D004285:Dogs; D005260:Female; D005931:Glottis / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D007828:Laryngoscopy; D053685:Laser Therapy; D008297:Male