Antiinflammatory triterpenoid saponins from the seeds of Aesculus chinensis.
Phytochemical study of the ethanol extract of the seeds of Aesculus chinensis led to the isolation of a new triterpenoid saponin (6), together with five known triterpenoid saponins (1-5). The structure of the new compound was elucidated on the basis of spectral data to be 21,28-di-O-acetylprotoaescigenin-3-O-[beta-D-glucopyranosyl(1-2)][beta-D-glucopyranosyl(1-4)]-beta-D-glucopyranosiduronic acid (aesculiside A, 6). The antiinflammatory activities of the four main saponins (1-4) were compared with those of total saponin extracts, and single saponins showed more potent activity than total saponin extracts in mice.
Division of Chinese Materia Medica and Natural Products, National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, Beijing, Peoples's Republic of China. hograwei@hotmail.com
Feng
F
Wei
Lin-Yun
LY
Ma
Wen-Tao
WT
Jin
Shuang-Cheng
SC
Ma
Guo-Zhu
GZ
Han
Ikhlas Ahmad
IA
Khan
Rui-Chao
RC
Lin
D031319:Aesculus; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014992:Xylenes / Q000009:adverse effects
C496671:21,28-di-O-acetylprotoaescigenin-3-O-(beta-D-glucopyranosyl(1-2)9beta-D-glucopyranosyl(1-4))-beta-D-glucopyranosiduronic acid; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; D014992:Xylenes