The development of clearance methods for measurement of glomerular filtration and tubular reabsorption.
This essay looks at the historical significance of four APS classic papers that are freely available online: Jolliffe N, Shannon JA, and Smith HW. The excretion of urine in the dog. III. The use of non-metabolized sugars in the measurement of the glomerular filtrate. Am J Physiol 100: 301-312, 1932 (http://ajplegacy.physiology.org/cgi/reprint/100/2/301). Shannon JA. The excretion of inulin by the dog. Am J Physiol 112: 405-413, 1935 (http://ajplegacy.physiology.org/cgi/reprint/112/3/405). Shannon JA and Fisher S. The renal tubular reabsorption of glucose in the normal dog. Am J Physiol 122: 765-774, 1938 (http://ajplegacy.physiology.org/cgi/reprint/122/3/765). Shannon JA, Farber S, and Troast L. The measurement of glucose Tm in the normal dog. Am J Physiol 133: 752-761, 1941 (http://ajplegacy.physiology.org/cgi/reprint/133/3/752).
Hostetter
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TH
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 6707 Democracy Blvd, Bethesda, MD 20892, USA. hostettert@extra.niddk.nih.gov
Meyer
T W
TW
D000042:Absorption; D000818:Animals; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006029:Glycosuria / Q000378:metabolism; D049673:History, 20th Century; D007678:Kidney Glomerulus / Q000502:physiology*; D007684:Kidney Tubules / Q000378:metabolism*; D010827:Physiology / Q000266:history*
D005947:Glucose