Synapse scaffolding: intersection of endocytosis and growth.
The Drosophila dynamin-associated protein Dap160, homolog of the vertebrate Intersectins, is thought likely to act as a molecular scaffold in the synaptic periactive zone. New mutant analyses have revealed separable roles for Dap160 in the regulation of vesicular endocytosis and synaptic growth.
Department of Biological Sciences, Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37232, USA. Kendal.Broadie@Vanderbilt.edu
Kendal
K
Broadie
D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology; D034281:Dynamins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D009479:Neuropeptides / Q000378:metabolism / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D013569:Synapses / Q000378:metabolism / Q000502:physiology*; D022161:Transport Vesicles / Q000502:physiology; D033921:Vesicular Transport Proteins
D033942:Adaptor Proteins, Vesicular Transport; C113692:Dap160 protein, Drosophila; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009479:Neuropeptides; D033921:Vesicular Transport Proteins; D034281:Dynamins