OBOC small-molecule combinatorial library encoded by halogenated mass-tags.
[reaction: see text] A bromine-/chlorine-containing mass-tag encoding strategy for a small-molecule OBOC combinatorial library is reported. The resulting MALDI FTMS isotope pattern of each tag clearly defines the component building blocks of each "hit" bead in an 1890-member demonstration library screened on-bead for binding against streptavidin via both enzyme-linked colorimetric and Quantum Dot/COPAS assays.
Hwang
Sung Hee
SH
Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, California 95616-5295, USA.
Lehman
Alan
A
Cong
Xin
X
Olmstead
Marilyn M
MM
Lam
Kit S
KS
Lebrilla
Carlito B
CB
Kurth
Mark J
MJ