Genetic and genomic approaches to reward and addiction.
Drug addiction is recognized as a mental disease affecting the brain's natural reward system. Drugs of abuse strongly activate reward structures in the brain and induce lasting changes in behavior that reflect changes in neuron physiology and biochemistry. With the ultimate goal of developing therapeutic interventions, it is of interest to determine the molecular and cellular components of motivation and reward, and identify those gene products that contribute to the process of drug addiction. Our laboratory has chosen three general genetic approaches to examine reward and addiction: reverse genetics to assess the role of candidate genes in drug responsiveness, forward genetics to discover novel regulators of dopamine transmission, and gene expression profiling to define gene sets in different brain structures that contribute to the molecular and neurobiological basis of reward.
Mohn
Amy R
AR
Department of Cell Biology, HHMI Laboratories, Duke University Medical Centre, Box 3287, CARL Building, Durham, NC 27710, USA.
Yao
Wei-Dong
WD
Caron
Marc G
MG
D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D009154:Mutation; D012201:Reward; D019966:Substance-Related Disorders / Q000235:genetics* / Q000523:psychology*; D009435:Synaptic Transmission / Q000235:genetics / Q000502:physiology
D018698:Glutamic Acid; D004298:Dopamine