Evaluation of tests based on the antibody response to keyhole limpet haemocyanin and soluble egg antigen to differentiate acute and chronic human schistosomiasis mansoni.
Specific IgG and IgM responses to soluble egg antigen (SEA) and keyhole limpet haemocyanin (KLH) were measured by ELISA in patients with acute and chronic schistosomiasis. The tests based upon IgM and IgG antibodies responses to KLH presented the best diagnostic discrimination, and can be used in conjunction with clinical and epidemiological data to the differential diagnosis of acute schistosomiasis.
Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.
Lílian
L
Beck
Daniele S M
DS
Van-Lüme
Joelma R de
JR
Souza
Clarice N Lins de
CN
Morais
Wlademir G
WG
Melo
Edeneide
E
Xavier
Constança S
CS
Barbosa
Marcílio L
ML
Aroucha
Ana Lúcia C
AL
Domingues
Tereza
T
Favre
Otávio
O
Pieri
Frederico G C
FG
Abath
Silvia M L
SM
Montenegro
D000208:Acute Disease; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D000947:Antigens, Helminth / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D015801:Helminth Proteins / Q000097:blood*; D006433:Hemocyanins / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015415:Biomarkers; D015801:Helminth Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C055560:p40 egg antigen, Schistosoma; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin