Intermediate precision study on a capillary electrophoretic method for chlortetracycline.
We describe an intermediate precision study on a capillary electrophoretic (CE) method for chlortetracycline. It is shown how in one setup the influence of the factors time, analyst, and equipment on the precision can be investigated. As different types of CE equipments were included, the transferability of the method could be examined. Both the qualitative and quantitative aspect of the method were investigated. It was shown that small adaptations in method conditions can have a large influence on the method transferability. Although the method could be transferred to different types of CE equipments, the precision of the method was found poor when the between-equipment variability was taken into account. Despite the use of an internal standard, the between injection variability was found rather high.
Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, Faculteit Farmaceutische Wetenschappen, K.U. Leuven, Leuven, Belgium.
Pieter
P
Dehouck
Phani K R
PK
Jaggavarapu
Aline
A
Desmedt
Ann
A
Van Schepdael
Jos
J
Hoogmartens
D002751:Chlortetracycline / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results
D002751:Chlortetracycline