The pioneering use of systems analysis to study cardiac output regulation.
This essay examines the historical significance of an APS classic paper that is freely available online: Guyton AC, Lindsey AW, and Kaufmann BN. Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180: 463-468, 1955 (http://ajplegacy.physiology.org/cgi/reprint/180/3/463).
John E
JE
Hall
D000818:Animals; D002302:Cardiac Output / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D004285:Dogs; D006321:Heart / Q000502:physiology; D049673:History, 20th Century; D008954:Models, Biological; D010827:Physiology / Q000266:history*