A new phenanthrene glycoside and other constituents from Dioscorea opposita.
Phytochemical investigation of the rhizome of Dioscorea opposita has led to the isolation of a new phenanthrene glycoside, 3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside (1), and five known compounds, soyacerebroside I (2), adenosine (3), beta-sitosterol (4), palmitic acid (5) and palmitoyloleoylphosphatidylcholine (6). Their structures were determined by spectroscopic methods, including 1D- and 2D-NMR. Compounds 1-6 exhibited no antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis.
Laboratoire de Pharmacognosie, Unité UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.
Marc
M
Sautour
Anne-Claire
AC
Mitaine-Offer
Tomofumi
T
Miyamoto
Hildebert
H
Wagner
Marie-Aleth
MA
Lacaille-Dubois
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D027742:Dioscorea; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts; D027343:Rhizome
C496664:3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside; D000935:Antifungal Agents; D006027:Glycosides; D010616:Phenanthrenes; D010936:Plant Extracts