Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study.
We administered a culturally corrected University of Pennsylvania Smell Identification Test (ccUPSIT) consisting of 25 odor items to 20 patients with 'Lubag' or X-linked dystonia-parkinsonism and 20 control subjects matched by sex, age, educational background, smoking history, and geographical origin. The mean ccUPSIT score of Lubag patients (18 +/- 3.19) was statistically lower (P = 0.003) than controls (20.5 +/- 3.02). The smell scores did not correlate with phenotype, severity of dystonia, or duration of disease. Nine of 20 Lubag patients (45%) had ccUPSIT scores below the mean, with the lowest score being 11. This pilot study suggests that olfactory dysfunction may occur in Lubag patients.
Department of Neurology, Mayo Clinic, 13400 E. Shea Boulevard, Scottsdale, AZ 85259, USA. evidente.virgilio@mayo.edu
Virgilio Gerald H
VG
Evidente
Raymund P
RP
Esteban
Jose Luis
JL
Hernandez
Filipinas F
FF
Natividad
Joel
J
Advincula
Katrina
K
Gwinn-Hardy
John
J
Hardy
Amanda
A
Singleton
Andrew
A
Singleton
D000328:Adult; D004421:Dystonia / Q000175:diagnosis* / Q000235:genetics*; D040181:Genetic Diseases, X-Linked / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009812:Odorants; D010300:Parkinson Disease / Q000175:diagnosis* / Q000235:genetics*; D010865:Pilot Projects; D012903:Smell / Q000235:genetics*