Translocation (16;18)(p13;q21.3) in follicular lymphoma.
We describe a novel t(16;18)(p13;q21.3) in a male patient with follicular lymphoma. This unique chromosomal rearrangement has never been described in patients with follicular lymphoma. The breakpoint of 16p13 has several hematopoietic neoplasm-related genes such as MHC2TA, a master regulatory gene for HLA-D, and BCMA, tumor necrosis factor receptor super-family. The majority of follicular lymphomas have a rearrangement of the BCL2 gene, which is a pathogenetic factor in their development. The diagnostic and prognostic significance of this new translocation is yet to be determined.
Mahmoodi
Mandana
M
Department of Pathology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA.
Tanev
Silvio S
SS
Punnett
Hope H
HH
Crilley
Pamela
P
Hou
J Steve
JS
D002885:Chromosomes, Human, Pair 16; D002887:Chromosomes, Human, Pair 18; D019254:Genes, bcl-2; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic