Stanniocalcin in terminally differentiated mammalian cells.
Stanniocalcin (STC) is a glycoprotein hormone originally found in teleost fish, where it regulates the calcium/phosphate homeostasis, and protects the fish against toxic hypercalcemia. STC was considered an exclusive fish protein, until the cloning of cDNA for human (in 1995) and murine (in 1996) STC. We originally reported a high constitutive content of STC in mammalian brain neurons, and found that the expression of STC occurred concomitantly with terminal differentiation of neural cells. Since then, we have investigated the expression of STC in relation to terminal cell differentiation also in mammalian hematopoietic tissue, and fat tissues. In this review we summarize our findings on STC expression during postmitotic differentiation in three different cell systems; in neural cells, in megakaryocytes and in adipocytes. We also present findings, suggesting that STC plays a role for maintaining the integrity of terminally differentiated mammalian cells.
Department of Pathology, Haartman Institute, University of Helsinki, P.O. Box 21 (Haartmaninkatu 3), Helsinki 00014, Finland.
Martina
M
Serlachius
Ke-Zhou
KZ
Zhang
Leif C
LC
Andersson
D017667:Adipocytes / Q000166:cytology; D000818:Animals; D002118:Calcium / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D005399:Fishes; D006023:Glycoproteins / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D008322:Mammals
D006023:Glycoproteins; C051795:teleocalcin; D002118:Calcium