Unspecific increase of antistreptolysin-O titer in acute guttate psoriasis.
An acute streptococcal infection is well-known to be a predisposing factor in acute guttate psoriasis. This study also revealed a high ASO titer in 11 of 13 patients at first examination. However, a non-specific ASO increase due to non-immunological reaction of serum lipoproteins with antistreptolysin-O, was found in 5 of these patients who visited our clinic at the evolving phase, 2 or 3 weeks after onset of the eruption but was no longer observed at 5-6 weeks and thereafter. On the other hand, specific ASO increase, which was not related to lipoproteins, was observed first in some patients at 3-4 weeks and at 7-10 weeks in all patients examined. These observations suggest the role of streptococcal lipoprotein alteration in the occurrence of this disease.
Department of Dermatology, Gunma University, School of Medicine, Maebashi, Japan.
H
H
Sato
H
H
Ishikawa
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D000989:Antistreptolysin / Q000032:analysis* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D011379:Prognosis; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology*; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000382:microbiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000175:diagnosis*
D000907:Antibodies, Bacterial; D015415:Biomarkers; D000989:Antistreptolysin