Surface properties and cell response of low metal ion release Ti-6Al-7Nb alloy after multi-step chemical and thermal treatments.
Ti-6Al-7Nb samples treated by innovative multi-step chemical and thermal processes were characterized in order to evaluate their surface properties and cell interaction. The main object was to asses if the treatments were effective in order to obtain a surface presenting at the same time bone-like apatite induction ability, low metal ion release, good cell response and high protein binding. The morphology, crystallographic structure, porosity and wettability of the treated materials were investigated, as well as their interaction with simulated body fluid during soaking for different times. Cytotoxicity, protein adsorption tests and in vitro fibroblast and osteoblast-like cell cultures were also performed.
Spriano
Silvia
S
Material Science and Chemical Engineering Department, University of Turin, Turin, Italy. silvia.spriano@polito.it
Bosetti
Michela
M
Bronzoni
Marco
M
Vernè
Enrica
E
Maina
Giovanni
G
Bergo
Valerio
V
Cannas
Mario
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001826:Body Fluids / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation; D048429:Cell Size; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003343:Corrosion; D006358:Hot Temperature; D006801:Humans; D007477:Ions; D008422:Materials Testing; D008670:Metals / Q000737:chemistry; D051379:Mice; D008968:Molecular Conformation; D041681:NIH 3T3 Cells; D016348:Osseointegration / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D016062:Porosity; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D007477:Ions; D008670:Metals; C070282:Ti-6Al-7Nb alloy; D014025:Titanium