The effects of castration and testosterone administration on mast cells and hydroxyproline in rat skin.
In rat skin of both sexes, significantly higher concentrations of mast cells were observed in the genital area as compared with the skin of the back. The hydroxyproline (HPL) value in the preputial skin was half that in the dorsal skin. The influence of castration and the administration of testosterone on male rat skin mast cells and HPL were investigated. A possible relationship was pointed out between HPL value and the mast cell population of the skin.
Department of Dermatology, Okayama University Medical School, Okayama 700, Japan.
M
M
Hagiyama
J
J
Arata
K
K
Tanioku
D000818:Animals; D002369:Castration; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005260:Female; D006909:Hydroxyproline / Q000032:analysis / Q000378:metabolism*; D007564:Japan; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D009919:Orchiectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012680:Sensitivity and Specificity; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D006909:Hydroxyproline