Intrinsic neuronal regulation of axon and dendrite growth.
Neurons extend long axons and highly branched dendrites, and our understanding of the essential regulators of these processes has advanced in recent years. In the past year, investigators have shown that transcriptional control, posttranslational degradation and signaling cascades may be master regulators of axon and dendrite elongation and branching. Thus, evidence is mounting for the importance of the intrinsic growth state of a neuron as a crucial determinant of its ability to grow, or to regenerate, axons and dendrites.
Department of Ophthalmology, McKnight Vision Research Center, Bascom Palmer Eye Institute, 1638 NW 10th Ave, Miami, Florida 33136, USA. jgoldberg@med.miami.edu
Jeffrey L
JL
Goldberg
D000818:Animals; D001369:Axons / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics; D003712:Dendrites / Q000502:physiology*; D005809:Genes, Regulator / Q000235:genetics; D006801:Humans; D009416:Nerve Regeneration / Q000235:genetics*; D009420:Nervous System / Q000254:growth & development*; D009473:Neuronal Plasticity / Q000235:genetics*; D011499:Protein Processing, Post-Translational / Q000235:genetics