Copper-catalyzed enantioselective conjugate addition of grignard reagents to acyclic enones.
A highly enantioselective Cu-catalyzed addition of Grignard reagents to acyclic aliphatic enones is described. In the presence of 5 mol % of CuBr.SMe2 and 6 mol % of JosiPhos diphosphine aliphatic enones react with Grignard reagents to provide beta-substituted linear ketones with high yields, regio-, and enantioselectivities.
Department of Organic Chemistry and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Fernando
F
López
Syuzanna R
SR
Harutyunyan
Adriaan J
AJ
Minnaard
Ben L
BL
Feringa