Repair renal tubular cells: a potential false-positive diagnosis in urine cytology.
To study the cytopathology of repair renal tubular cells (RRTCs), the Papanicolaou-stained urine sediments of 371 patients with mild and moderate renal tubular injuries were reviewed. In 46 cases, the urine sediments showed, in addition to a mild or moderate increase in number of RTCs, a few isolated and clustered RRTCs that displayed well- or ill-defined, variably abundant, granular or vacuolated cytoplasm; slightly pleomorphic nuclei; and conspicuous or prominent nucleoli. A spectrum of nuclear changes ranging from mild to moderate atypias and/or severe atypia were present in many cases. These RRTCs stained strongly positively with vimentin antibody in 92.3% of the cases.
Nguyen
Gia-Khanh
GK
Department of Laboratory Medicine and Pathology, University of Alberta Hospitals, Edmonton, Alberta T6G 2B7, Canada. knguyen@cha.ab.ca
Smith
Roxanne
R
D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000473:pathology; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014556:Urine / Q000166:cytology* / Q000502:physiology; D014746:Vimentin / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
D014746:Vimentin