[Therapeutical effects of esculentoside A on rats with MsPGN induced by anti-Thy1.1 antibody].
OBJECTIVE
To observe the therapeutical effects of esculentoside A (EsA) on rats with mesangial proliferative glomerulonephritis (MsPGN) induced by anti-Thy1.1 antibody and make a comparison of the effects between EsA and dexamethasone (DXM).


METHODS
Wistar rats with MsPGN induced by anti-Thy1.1 serum (ATS) were randomly divided into 3 groups: EsA group, DXM group, and model group. Moreover, a normal group was used for comparison. The BUN, SCr, urinary protein and renal pathological changes were examined after 7 d treatment with EsA and DXM.


RESULTS
The urinary protein, cell count and mesangium area of glomerulus were significantly higher in all modeled groups than in normal group (P<0.001-0.05), and they were significantly lower in the treated groups than in untreated group (P<0.001-0.01).


CONCLUSIONS
The results suggest that EsA is effective for reducing the urinary protein excretion and inhibiting the proliferation process of glomerular mesangium and matrix in rats with MsPGN.
Department of Nephrology, The First Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China.
Ke-fei
KF
Zhang
Liang
L
Zhang
Xiong-fei
XF
Wu
Xiang-gui
XG
Zhang
Hong
H
Yu
Yang-hua
YH
Yi
Shi-qi
SQ
Zhao
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D000906:Antibodies; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005920:Glomerular Mesangium / Q000378:metabolism; D015432:Glomerulonephritis, Membranoproliferative / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use*; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification / Q000627:therapeutic use*; D018800:Thy-1 Antigens / Q000276:immunology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000906:Antibodies; D004365:Drugs, Chinese Herbal; D012503:Saponins; D018800:Thy-1 Antigens; C076297:esculentoside A; D009828:Oleanolic Acid