Sustained release of BSA from a novel drug delivery matrix -- bullfrog skin collagen film.
A novel drug delivery system, bullfrog skin collagen film, was employed to release bovine serum albumin (BSA). The biophysical properties of bullfrog skin collagen film used were evaluated by thermal denaturation temperature and percentage water loss. The film obtained exhibited good stability and can be taken as a good candidate for drug delivery matrix. Compared with conventional collagen from molecular weight and amino acid composition, bullfrog skin collagen showed significant differences. For safety considerations, bullfrog skin collagen has great advantages. The release kinetics of BSA from bullfrog skin collagen film was measured in vitro. The results indicated bullfrog skin collagen film could be used for sustained release of BSA. Thus, bullfrog skin collagen film can be taken as a novel drug delivery system.
Li
He
H
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, P.O. Box 415, Chengdu, Sichuan 610041, PR China. leon_cd16@hotmail.com
Wang
Diqiang
D
Li
Songjun
S
Liu
Bailing
B
Gao
Lizhen
L
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002152:Calorimetry, Differential Scanning / Q000379:methods; D003094:Collagen / Q000737:chemistry* / Q000648:ultrastructure; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D011892:Rana catesbeiana; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D012867:Skin
D000596:Amino Acids; D004337:Drug Carriers; D012710:Serum Albumin, Bovine; D003094:Collagen