[Effect of iron and zinc levels in diet on development of bone in growing rats exposed to lead].
OBJECTIVE
The purpose of this paper was to explore the effect of iron and zinc in diet on development of bone in growing rats exposed to lead and observed the change of bone mineral content (BMC) and bone mineral density (BMD).


METHODS
The growing rats were fed with diet added with different levels of iron, zinc and lead for 12 weeks.


RESULTS
Long-term exposure to lead may inhibit the development of bone and reduce BMC and BMD, it can be improved the weight and length of bone and increased BMC and BMD following the increased in iron and zinc levels in the diets, but the lead level of bone increases.


CONCLUSIONS
Supplementary suitable iron or/and zinc could improve the BMC and BMD, the mechanism of iron and zinc in diets on bone exposed to lead should be further research.
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Jianqiang
J
Lai
Jing
J
Zhou
Shian
S
Yin
Xianfeng
X
Zhao
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D007501:Iron / Q000494:pharmacology*; D007854:Lead / Q000032:analysis / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000494:pharmacology*
D007854:Lead; D007501:Iron; D015032:Zinc