Patch-clamp and chloride channels in Ascaris suum.
Single-channel electrophysiology is an invaluable tool fo the study of ion channels. However, it is a technique that has failed to attract widespread use by parasitologists. Here, Diane Dixon and Richard Martin outline the principles undelrying single channel recording and highlight its uses in the discovery of a new and unusual chloride channel in the musculature of Ascaris suum.
Dixon
D M
DM
Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Sciences, Summerhall, Edinburgh, UK EH9 1QH.
Martin
R J
RJ