Translocation (16;18)(p13;q21.3) in follicular lymphoma.
We describe a novel t(16;18)(p13;q21.3) in a male patient with follicular lymphoma. This unique chromosomal rearrangement has never been described in patients with follicular lymphoma. The breakpoint of 16p13 has several hematopoietic neoplasm-related genes such as MHC2TA, a master regulatory gene for HLA-D, and BCMA, tumor necrosis factor receptor super-family. The majority of follicular lymphomas have a rearrangement of the BCL2 gene, which is a pathogenetic factor in their development. The diagnostic and prognostic significance of this new translocation is yet to be determined.
Department of Pathology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA.
Mandana
M
Mahmoodi
Silvio S
SS
Tanev
Hope H
HH
Punnett
Pamela
P
Crilley
J Steve
JS
Hou
D002885:Chromosomes, Human, Pair 16; D002887:Chromosomes, Human, Pair 18; D019254:Genes, bcl-2; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic