Comparison of cortical 5-HT2A receptor binding in bulimia nervosa patients and healthy volunteers.
OBJECTIVE
Bulimia nervosa has been associated with alterations in central serotonergic (5-HT) function. This study investigated iodine-labeled 4-amino-N-[1-[3-(4-fluorophenoxy) propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide ((123)I-5-I-R91150) binding to the 5-HT(2A) receptor in the brain by using single photon emission computed tomography in acutely ill bulimia nervosa patients.


METHODS
Cortical (123)I-5-I-R91150 binding in 10 normal-weight patients with bulimia nervosa, purging type, was compared with that of 11 healthy volunteers.


RESULTS
The 5-HT(2A) binding index of the bulimia nervosa patients, with and without correction for age, was not significantly different from that of the comparison group.


CONCLUSIONS
As a group, acutely ill bulimia nervosa patients cannot be discriminated from healthy subjects on the basis of cortical (123)I-5-I-R91150 binding to the 5-HT(2A) receptor.
Goethals
Ingeborg
I
Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. ingeborg.goethals@ugent.be.
Vervaet
Myriam
M
Audenaert
Kurt
K
Van de Wiele
Christophe
C
Ham
Hamphrey
H
Vandecapelle
Marleen
M
Slegers
Guido
G
Dierckx
Rudi
R
van Heeringen
Cees
C
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D002032:Bulimia / Q000000981:diagnostic imaging / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D010880:Piperidines; D011485:Protein Binding; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D010880:Piperidines; C105020:R 91150; D044402:Receptor, Serotonin, 5-HT2A