Protein-based tissue engineering in bone and cartilage repair.
Bioactive proteins signal host or transplanted cells to form the desired tissue type. Matrix systems are utilized to locally deliver the proteins and to maintain effective protein concentrations. For some indications, a matrix is required to define the physical form of the regenerated tissue. Substantial progress has been made in bone tissue engineering in recent years, based on the results of controlled clinical studies using bone morphogenetic proteins. Ongoing research in this area centers on the design of additional delivery matrices to expand the clinical indications, using synthetic delivery systems that mimic biological qualities of the natural materials currently in use. Although a similar rationale exists for the regeneration of articular cartilage with bioactive factors, advancement in this area has not been as substantial.
Wozney
John M
JM
Wyeth Research, 87 CambridgePark Drive, Cambridge, Massachusetts 02140, USA. jwozney@wyeth.com
Seeherman
Howard J
HJ
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage; D001861:Bone Regeneration; D002358:Cartilage, Articular / Q000502:physiology; D006133:Growth Substances / Q000627:therapeutic use; D006801:Humans; D015202:Protein Engineering / Q000379:methods; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods; D014945:Wound Healing
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances