Aggressive multimodal treatment for peritoneal dissemination and needle tract implantation of hepatocellular carcinoma: a case report.
We encountered a patient with hepatocellular carcinoma (HCC) with peritoneal dissemination and needle tract implantation, both of which were strongly suspected to have been caused by percutaneous needle biopsy. The patient was a 65-year-old man. Partial hepatectomy of subsegment VI had been performed following the diagnosis of HCC by percutaneous needle biopsy in February 1997. After this first surgery, the patient additionally underwent five further surgeries for the treatment of intrahepatic recurrences, peritoneal recurrences and needle tract implantation caused by the percutaneous needle biopsy. The intrahepatic and peritoneal recurrences were surgically controlled for 3 years after the fifth operation. The needle tract implantation was first resected in February 2001. Since then, treatment by surgery and radiotherapy has been administered twice for local recurrences forming tumor thrombosis of the abdominal wall. Now, 7 years after the first surgery, the patient remains alive without any evidence of recurrence. This case report serves to emphasize that needle tract implantation and peritoneal seeding caused by percutaneous needle biopsy are rare but possible complications. When such iatrogenic spreading of malignant cells occurs, aggressive multimodal treatment is well worth considering. Wide resection of the tumor including the adjacent soft tissues should be performed in these cases, considering that the tumor spreads along the subcutaneous veins in needle tract implantation of HCC and repeated aggressive surgeries could provide good local control.
Takahashi
Hidenori
H
Department of Surgery and Clinical Oncology, Osaka University, Graduate School of Medicine, Osaka 565-0871, Japan. h-takaha@dd.iij4u.or.jp
Konishi
Masaru
M
Nakagohri
Toshio
T
Inoue
Kazuto
K
Takahashi
Shinichiro
S
Tanizawa
Yutaka
Y
Monden
Morito
M
Kinoshita
Taira
T
D000368:Aged; D001707:Biopsy, Needle / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000556:secondary* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000556:secondary; D020246:Venous Thrombosis / Q000209:etiology / Q000473:pathology