Diagnostic value of reverse transcription-PCR of amniotic fluid for prenatal diagnosis of congenital rubella infection in pregnant women with confirmed primary rubella infection.
The diagnostic value of RT-PCR of amniotic fluid (AF) for prenatal diagnosis of congenital rubella virus infection in 45 pregnant women with confirmed primary infection was assessed. Specificity of RT-PCR was 100% and sensitivity ranged between 83 and 95%.
Service de Microbiologie-Immunologie biologique, Hôpital Antoine Béclère, Clamart, France.
Muriel
M
Macé
Denis
D
Cointe
Caroline
C
Six
Daniel
D
Levy-Bruhl
Isabelle
I
Parent du Châtelet
Didier
D
Ingrand
Liliane
L
Grangeot-Keros
D000653:Amniotic Fluid / Q000821:virology*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000821:virology; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D011296:Prenatal Diagnosis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods*; D012409:Rubella / Q000175:diagnosis / Q000821:virology; D012410:Rubella Syndrome, Congenital / Q000175:diagnosis* / Q000821:virology; D012412:Rubella virus / Q000235:genetics / Q000302:isolation & purification*; D012680:Sensitivity and Specificity