Polyomaviruses and primary central nervous system lymphomas.
The authors investigated the potential association of human primary CNS non-Hodgkin lymphoma (PCNSL) with polyomavirus in HIV-1 infected and uninfected individuals. Immunohistochemical analysis of CNS biopsies from 19 HIV-negative and 17 HIV-positive patients and PCR analysis of 12 HIV-negative and 14 HIV-positive patients revealed that the lymphomas were uniformly negative for polyomaviruses. The authors conclude that polyomaviruses are unlikely to be related to the pathogenesis of most PCNSL.
Murray
Jacinta M
JM
Department of Pathology, Box 1143, Mount Sinai School of Medicine, New York, NY 11377, USA. jacinta.murray@mssm.edu
Morgello
Susan
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000957:Antigens, Viral, Tumor / Q000032:analysis; D002467:Cell Nucleus / Q000821:virology; D016543:Central Nervous System Neoplasms / Q000821:virology*; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011120:Polyomavirus / Q000276:immunology / Q000302:isolation & purification*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D000957:Antigens, Viral, Tumor; D016159:Tumor Suppressor Protein p53