A stochastic model for the mutation-selection balance in an infinite asexual population with a genome of fixed size.
A stochastic model is presented which describes the evolution of a genome of a haploid species in an infinite population. The genome is a finite set of elements. The elements are divided into different classes according to their effect on the fitness of the organism. Repeated mutations of the genome elements are permitted, in particular positive mutations are introduced. The distribution of the deleterious elements in the genome with respect to the impact on the fitness is given after the replication step. The steady state is fully described including the distribution and the fitness.
Fukshansky
Anna
A
Department of Computer Science, Royal Holloway University of London, Egham, Surrey, TW20 0EX, UK. a.fukshansky@cs.rhul.ac.uk
D000818:Animals; D016678:Genome; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D011157:Population Dynamics; D012100:Reproduction, Asexual; D012641:Selection, Genetic