Successful revascularization of acute carotid stent thrombosis by facilitated thrombolysis.
A 64-year-old woman undergoing protected carotid artery stent placement developed acute stent thrombosis despite pretreatment with combined antiplatelet therapy. A reduced dose of recombinant tissue plasminogen activator and a half-dose bolus of abciximab were administered intra-arterially via superselective catherization followed by systemic intravenous infusion of abciximab for 12 hours. Control angiography showed complete restoration of blood flow paralleled by neurologic improvement.
Second Department of Medicine, University of Vienna Medical School, Vienna, Austria.
Sabine
S
Steiner-Böker
Manfred
M
Cejna
Christian
C
Nasel
Erich
E
Minar
Christoph W
CW
Kopp
D000077284:Abciximab; D000208:Acute Disease; D015901:Angiography, Digital Subtraction; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D016893:Carotid Stenosis / Q000628:therapy*; D002533:Cerebral Angiography; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D015607:Stents / Q000009:adverse effects*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D005343:Fibrinolytic Agents; D007140:Immunoglobulin Fab Fragments; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; D000077284:Abciximab