Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics.
Several nocathiacin I analogues (4-35) were synthesized and evaluated for their antibacterial activity. Most of these semi-synthetic analogues retained very good in vitro and in vivo antibacterial activity of 1.
Naidu
B Narasimhulu
BN
The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. narasimhulu.naidu@bms.com
Sorenson
Margaret E
ME
Zhang
Yunhui
Y
Kim
Oak K
OK
Matiskella
John D
JD
Wichtowski
John A
JA
Connolly
Timothy P
TP
Li
Wenying
W
Lam
Kin S
KS
Bronson
Joanne J
JJ
Pucci
Michael J
MJ
Clark
Junius M
JM
Ueda
Yasutsugu
Y
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects / Q000254:growth & development; D036341:Intercellular Signaling Peptides and Proteins; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship
D000588:Amines; D000900:Anti-Bacterial Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C463319:nocathiacin I