Pseudopyogenic granuloma: effects of corticosteroid on newly-formed vessels.
Papular lesions of pseudopyogenic granuloma were examined before and during treatment with systemic corticosteroid using both light and electron microscopy. Before treatment, these lesions showed a proliferation of vessels lined with plump endothelial cells and heavy lymphohistiocytic infiltrates with numerous eosinophils in the dermis. During treatment, flattened papules showed a dilatation of vessels lined with flattened endothelial cells, extravasation of red cells, discontinuity of endothelial basal lamina, and, ultimately, discontinuity of the endothelial cells themselves. Eosinophils were rarely found. From these findings, it can be said that the morphological effects of corticosteroid on microvasculature have in part been elucidated.
Kimura
S
S
Department of Dermatology , Keio University School of Medicine, Shinjuku-ku, Tokyo 160, Japan.
D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000188:drug therapy* / Q000473:pathology*; D001707:Biopsy, Needle; D001808:Blood Vessels / Q000473:pathology / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D011239:Prednisolone / Q000008:administration & dosage*; D016896:Treatment Outcome
D011239:Prednisolone