Genetic mosaic analysis in the nervous system.
Genetic mosaic techniques provide a powerful tool for dissecting gene function in the intricate genetic networks that underlie the formation and function of nervous systems. For instance, it is possible to make individual cells or groups of cells homozygous for mutations of interest at specific points during an organism's development. It is also possible to resolve lineage relationships and to characterize cellular morphology and connectivity. Current techniques for creating genetically mosaic organisms incorporate improved controls over clone induction, identification, and/or mosaic tissue characterization.
Department of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801, USA.
Christopher T
CT
Zugates
Tzumin
T
Lee
D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D048430:Cell Shape / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008967:Molecular Biology / Q000379:methods* / Q000639:trends; D009030:Mosaicism / Q000196:embryology*; D009154:Mutation / Q000235:genetics; D009420:Nervous System / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D010641:Phenotype; D011995:Recombination, Genetic / Q000235:genetics
D005819:Genetic Markers