Epithelioid variant of pleomorphic liposarcoma: report of a case.
A case of an epithelioid variant of pleomorphic liposarcoma (PL) arising in the back of a 72-year old male is presented. The lesion was a well-circumscribed but unencapsulated, yellowish white mass measuring 11 x 10 x 9 cm in the subcutis and muscle. Histologically, the tumor consisted of three elements; an epithelioid cell element occupying about 50%, a lipogenic and mixed lipogenic and epithelioid cell element occupying 40%, and a malignant fibrous histiocytoma-like element. The lipogenic area was composed of uni- and multivacuolated pleomorphic lipoblasts. Immunohistochemically, the tumor was positive for vimentin, epithelial membrane antigen, and CD10. It was negative for desmin, alpha-smooth muscle actin, muscle actin, S-100 protein, and cytokeratins 8 and 18. The epithelioid variant of PL should be differentiated from metastatic renal cell carcinoma and adrenal cortical adenocarcinoma.
Department of Pathology, The Jikei Daisan Hospital, The Jikei University School of Medicine, 4-11-1 Izumihoncho, Komaeshi, Tokyo 201-8601, Japan. maasafu@jikei.ac.jp
Masaharu
M
Fukunaga
Kouich
K
Nomura
D000368:Aged; D001415:Back; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008080:Liposarcoma / Q000737:chemistry / Q000473:pathology*; D008297:Male; D018396:Mucin-1 / Q000032:analysis; D015260:Neprilysin / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D018396:Mucin-1; D014746:Vimentin; D015260:Neprilysin