Successful use of topical cysteamine formulated from the oral preparation in a child with keratopathy secondary to cystinosis.
OBJECTIVE
To report the successful use of topical cysteamine formulated from the oral preparation in the treatment of severe photophobia from corneal crystal deposition in cystinosis.


METHODS
Interventional case report.


METHODS
Retrospective chart review.


RESULTS
An 8-year-old boy with nephropathic cystinosis was experiencing debilitating and worsening photophobia from corneal crystal deposition. Because no parenteral cysteamine was available nationally, the oral capsule was used to formulate an ophthalmic preparation for compassionate use. After 8 months of topical application, the patient has marked improvement of his corneal disease, both subjectively and objectively.


CONCLUSIONS
In situations of need, there is a role for the formulation of ophthalmic cysteamine from its oral preparation.
Khan
Arif O
AO
King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia. arif.khan@mssm.edu <arif.khan@mssm.edu>
Latimer
Bruce
B
D000287:Administration, Topical; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D002648:Child; D003316:Corneal Diseases / Q000188:drug therapy* / Q000209:etiology; D003543:Cysteamine / Q000008:administration & dosage*; D003554:Cystinosis / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D004364:Pharmaceutical Preparations; D020795:Photophobia / Q000188:drug therapy / Q000209:etiology; D012189:Retrospective Studies
D002214:Capsules; D009883:Ophthalmic Solutions; D004364:Pharmaceutical Preparations; D003543:Cysteamine