In vitro antifungal susceptibility of Cryptococcus gattii.
We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans. MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 microg/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 microg/ml). In general, C. gattii was less susceptible than C. neoformans to all drugs tested, with the exception of amphotericin B and flucytosine.
Serviçio de Micología Médica, Instituto de Pesquisa Clínica Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.
Luciana
L
Trilles
Belkys
B
Fernández-Torres
Márcia dos Santos
Mdos S
Lazéra
Bodo
B
Wanke
Josep
J
Guarro
D000935:Antifungal Agents / Q000494:pharmacology*; D003454:Cryptococcus / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
D000935:Antifungal Agents; D011799:Quinazolines; D013844:Thiazoles; D014230:Triazoles; C104066:ER 30346; C112424:albaconazole