Re-structuring the host cell: up close with Salmonella's molecular machinery.
A common theme in bacterial disease is the manipulation of the eukaryotic cytoskeleton by pathogenic factors. Understanding how virulence factors operate to achieve these alterations is a growing and important research effort. This review focuses on several virulence factors from the pathogen Salmonella, and considers the contributions of structural biology to our appreciation of bacterial modulation of cytoskeletal dynamics.
Laboratory of Structural Microbiology, Rockefeller University, New York, NY 10021, USA. stebbins@rockefeller.edu
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D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D021381:Protein Transport; D012475:Salmonella / Q000378:metabolism / Q000472:pathogenicity*; D037521:Virulence Factors / Q000737:chemistry / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism
D001426:Bacterial Proteins; D037521:Virulence Factors; D020741:rho GTP-Binding Proteins