Pityriasis lichenoides et varioliformis acuta immunohistopathologic study.
Immunoglobulin M and complement (Clq, C3 and C9) were found to be deposited together in the walls of affected blood vessels and also in the basement membrane zone of skin lesions from two patients with pityriasis lichenoides et varioliformis acuta (PLVA). The fluorescence appeared to be most intensely distributed in blood vessels which were affected by inflammatory infiltrates and frequently showed hyaline or fibrinoid changes of their walls. Deposits of C3 activator, fibrin and albumin were not observed. These findings suggest that the disease process in PLVA is the result of a vasculitis mediated by an immune complex and possibly by activation of the classical complement pathway. In addition, serum IgM was slightly increased in both patients.
Hayashi
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Department of Dermatology, Jichi Medical School, Minami-kawachi-machi, Kawachi-gun, Tochigi-ken, Japan.
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D003176:Complement C3 / Q000032:analysis / Q000276:immunology*; D003186:Complement C9 / Q000032:analysis / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis / Q000276:immunology; D007150:Immunohistochemistry; D007564:Japan; D008297:Male; D008875:Middle Aged; D017514:Pityriasis Lichenoides / Q000276:immunology* / Q000473:pathology*; D011379:Prognosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D003176:Complement C3; D003186:Complement C9; D007075:Immunoglobulin M