Synthesis and biological activity of new derivatives of 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid.
New 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid derivatives (8-14) were synthesized by condensation of N(3)-substituted amidrazones (1-7) with maleic anhydride. Molecular structure of obtained compounds was confirmed by an elemental analysis, IR and (1)H NMR spectra, and the X-ray crystallography for compound 11. The influence of the compound 9 on the central nervous system (CNS) of mice in some behavioural test was examined. The investigated compound showed anticonvulsive activity and potent antinociceptive action.
Modzelewska-Banachiewicz
Boźena
B
Department of Organic Chemistry, Medical University, Jagiellońska 13, 85-067 Bydgoszcz, Poland. modzel@panaceum.am.lublin.pl
Banachiewicz
Jacek
J
Chodkowska
Anna
A
Jagiełło-Wójtowicz
Ewa
E
Mazur
Liliana
L
D000475:Alkenes / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000475:Alkenes; D000927:Anticonvulsants; D014230:Triazoles; C013658:propylene