Effect of preoperative administration of tepoxalin on hemostasis and hepatic and renal function in dogs.
Preemptive analgesia is an important part of surgical management, but some NSAIDs can adversely affect platelet function or renal or hepatic status. Tepoxalin is approved in the United States for control of pain and inflammation associated with arthritis and in Europe for relief of pain caused by musculoskeletal disorders. In this study, no significant effects on indices of hemostasis or renal or hepatic function were detected when a single preoperative oral dose of tepoxalin was administered to young healthy dogs undergoing anesthesia and surgery.
Kay-Mugford
Patricia A
PA
Schering-Plough Animal Health, Union, NJ, USA.
Grimm
Kurt A
KA
Weingarten
Allan J
AJ
Brianceau
Philippe
P
Lockwood
Patrick
P
Cao
Jean
J
D000698:Analgesia / Q000379:methods / Q000662:veterinary; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004283:Dog Diseases / Q000188:drug therapy / Q000517:prevention & control; D004285:Dogs; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006488:Hemostasis, Surgical; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010146:Pain / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary; D011229:Preanesthetic Medication / Q000662:veterinary*; D011720:Pyrazoles / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D011897:Random Allocation; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; C073135:tepoxalin