Effects of Magnolol and Honokiol on the activities of streptococcal glucosyltransferases both in solution and adsorbed on an experimental pellicle.
OBJECTIVE
To investigate the inhibitory effects of Magnolol and Honokiol on the activity of streptococcal glucosyltransferases (Gtfs).


RESULTS
The effect of Magnolol and Honokiol that inhibits the activities of streptococcal GtfB, GtfC, GtfD and GtfS was explored with standard assays. The results showed that both samples can efficiently inhibit the activity of all Gtfs in solution (66.4-96.3%) and adsorbed on the surface of saliva-coated hydroxyapatite (sHA) beads (65.5-92.7%) at concentrations between 1.25 and 5.0 mg ml(-1). Furthermore, Magnolol had a stronger inhibition of four kinds of Gtfs than Honokiol both in solution and adsorbed on the surface of sHA beads at concentrations between 0.04 and 0.63 mg ml(-1) (P < 0.05).


CONCLUSIONS
Magnolol had significant effects on the activities of streptococcal Gtfs.


CONCLUSIONS
Magnolol as a natural herb can be developed into a new oral hygiene product to prevent plaque formation.
Division of Infectious Disease, 1st Affiliated Hospital, Medical College of Zhejiang University, Qingchun Rd. 79, Hangzhou, China. lijun@hz.cn
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Jun
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Jifang
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Miaoquan
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Yingyan
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Xihong
D000327:Adsorption; D001713:Biphenyl Compounds / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005936:Glucans; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D017705:Lignans / Q000494:pharmacology*; D008863:Microspheres; D013291:Streptococcus / Q000201:enzymology*; D000498:Allyl Compounds; D010636:Phenols
D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D005936:Glucans; D005964:Glucosyltransferases; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols; C036655:1,3-alpha-D-glucan synthase