Towards the prevention of transfusion-transmitted infectious diseases.
Transfusion-transmission of viral infections, such as HIV and hepatitis C virus, were once the scourge of blood transfusion. However, due to remarkable progress over the last 30 years, tests for viral proteins, antibody responses and more recently, viral nucleic acids, have virtually eliminated these risks. This review summarizes these advances in an historical context, describes new methodologies on the horizon, and discusses residual infectious risks associated with blood transfusion.
Schuetz
Audrey
A
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Roback
John D
JD
D001424:Bacterial Infections / Q000517:prevention & control / Q000635:transmission; D006800:Deltaretrovirus Infections / Q000517:prevention & control / Q000635:transmission; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission; D006525:Hepatitis, Viral, Human / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D017096:Prion Diseases / Q000517:prevention & control / Q000635:transmission; D065227:Transfusion Reaction