The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease.
Bronchial hyperresponsiveness is present in virtually all patients with asthma and in more than two thirds of patients with chronic obstructive pulmonary disease. Thus far, methacholine and histamine are usually used to measure bronchial hyperresponsiveness. Both are direct stimuli, because they act directly on airway smooth muscle. Another possible stimulus to measure bronchial hyperresponsiveness is AMP. AMP is an indirect stimulus, because it acts via the release of histamine and other mediators from immunologically primed mast cells. There is increasing interest in the role of AMP as a bronchoconstrictor stimulus because it has been suggested that the concentration of AMP causing the FEV 1 to decrease by 20% (PC 20 AMP) may be used as a noninvasive marker of airway inflammation. The aim of this article was to review the literature assessing AMP's value in asthma and chronic obstructive pulmonary disease.
van den Berge
Maarten
M
Department of Pulmonology, University Hospital Groningen, The Netherlands.
Polosa
Riccardo
R
Kerstjens
Huib A M
HA
Postma
Dirkje S
DS
D000249:Adenosine Monophosphate / Q000037:antagonists & inhibitors / Q000276:immunology*; D000318:Adrenergic beta-Agonists / Q000276:immunology / Q000627:therapeutic use; D001249:Asthma / Q000276:immunology*; D015415:Biomarkers; D016535:Bronchial Hyperreactivity / Q000276:immunology*; D001985:Bronchial Provocation Tests; D006801:Humans; D008407:Mast Cells / Q000276:immunology; D011014:Pneumonia / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000276:immunology*
D000318:Adrenergic beta-Agonists; D015415:Biomarkers; D000249:Adenosine Monophosphate