Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis.
OBJECTIVE
To assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP-3) and macrophage colony-stimulating factor (M-CSF) in patients with ankylosing spondylitis (AS).


METHODS
Serum levels of MMP-3 and M-CSF were measured in AS patients who did and did not receive infliximab treatment. These were compared with those of 28 healthy subjects.


RESULTS
In the group of AS patients not treated with biologics, both M-CSF and MMP-3 correlated with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) values, but not with each other. Logistic regression analysis showed that MMP-3 values were high in those with severely active disease. Infusions of infliximab in AS patients led to a significant decrease in the values of the BASDAI as well as the serum MMP-3, but no change in the serum M-CSF values.


CONCLUSIONS
MMP-3 and M-CSF are potentially useful markers of AS disease activity.
University of California Los Angeles, USA.
Chunhua
C
Yang
Jieruo
J
Gu
Markus
M
Rihl
Dominique
D
Baeten
Feng
F
Huang
Miansong
M
Zhao
Hanwei
H
Zhang
Walter P
WP
Maksymowych
Filip
F
De Keyser
Eric M
EM
Veys
David T Y
DT
Yu
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015415:Biomarkers; D005260:Female; D006801:Humans; D000069285:Infliximab; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood* / Q000235:genetics; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000097:blood* / Q000188:drug therapy / Q000235:genetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D016173:Macrophage Colony-Stimulating Factor; D000069285:Infliximab; D019278:Matrix Metalloproteinase 3