Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats.
The modifying effects of administering an ethyl acetate extract of Kurosu (EK), a vinegar made from unpolished rice, in drinking water on the development of azoxymethane (AOM)-induced colon carcinogenesis were investigated in male F344 rats. Animals were given 2 weekly subcutaneous injections of AOM (20 mg/kg body weight). They also received drinking water containing 0%, 0.05%, or 0.1% EK for 35 wk, starting 1 wk after the last dosing of AOM. EK administration significantly inhibited the incidence and multiplicity of colon adenocarcinoma (P < 0.05), compared with those in the AOM alone group. These findings suggest that EK may be effective for inhibiting colon carcinogenesis.
Shimoji
Yumi
Y
Research Center, Tamanoi Vinegar, Co., Ltd., Nara, Japan.
Kohno
Hiroyuki
H
Nanda
Kumiko
K
Nishikawa
Yasushi
Y
Ohigashi
Hajime
H
Uenakai
Kazuo
K
Tanaka
Takuji
T
D019342:Acetic Acid / Q000494:pharmacology*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001397:Azoxymethane / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D008297:Male; D012275:Oryza / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D010936:Plant Extracts; D001397:Azoxymethane; D019342:Acetic Acid