Molecular genetics of hereditary hair and nail disease.
Hair and nail development have many similarities and are likely to share many developmental pathways. This is evident from the ectodermal dysplasias that affect both appendages. Of special interest are syndromic disorders as they show the effects of disturbances in molecular pathways that are essential for normal embryonic development. In this review, recent results from studies of syndrome affecting hair and nail development will be discussed.
Dermatology Department, University Hospital Maastricht, the Netherlands. mvst@sder.azm.nl
M A M
MA
van Steensel
M
M
van Geel
P M
PM
Steijlen
D002448:Cell Adhesion / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D003896:Desmosomes / Q000502:physiology; D005786:Gene Expression Regulation; D006201:Hair Diseases / Q000235:genetics* / Q000473:pathology*; D018859:Hair Follicle / Q000196:embryology / Q000503:physiopathology; D006801:Humans; D009260:Nail Diseases / Q000235:genetics* / Q000473:pathology*; D009262:Nails / Q000196:embryology / Q000503:physiopathology; D013577:Syndrome