Utility of currently available modes of therapy in reaching lipid goals.
The National Cholesterol Education Program Adult Treatment Panel III lipid management guidelines emphasize the importance of matching the intensity of lipid modification therapy to each patient's risk of coronary heart disease. For many patients who are at low risk, nonpharmacologic interventions such as diet, exercise, and smoking cessation can be effective lipid-lowering strategies. However, many patients require the addition of drug therapy to achieve lipid targets. Currently available lipid-modifying drugs include bile acid sequestrants, fibrates, nicotinic acid, cholesterol absorption inhibitors, and statins. In addition, nonprescription agents such as plant stanols and sterols are available to modify plasma lipid levels. These agents can be used individually or coadministered to achieve lipid goals.
University of Pennsylvania Health System, Cardiovascular Division, Philadelphia Heart Institute, Second Floor, 39th & Market Streets, Philadelphia, PA 19104, USA. kspratt@uphs.upenn.edu
Kelly Anne
KA
Spratt
Margo A
MA
Denke
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D002995:Clofibric Acid / Q000627:therapeutic use; D003327:Coronary Disease / Q000517:prevention & control; D005395:Fish Oils / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008019:Life Style; D008055:Lipids / Q000097:blood*; D009525:Niacin / Q000627:therapeutic use
D000924:Anticholesteremic Agents; D005395:Fish Oils; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D008055:Lipids; D009525:Niacin; D002995:Clofibric Acid