Upper tract tumour after radical cystectomy for transitional cell carcinoma of the bladder: incidence and risk factors.
OBJECTIVE
To review the incidence, pattern and outcome of upper tract transitional cell carcinoma (TCC) after radical cystectomy for carcinoma of the bladder, and identify risk factors for its development.


METHODS
The records of 235 consecutive patients who had a radical cystectomy and urinary diversion for TCC at the authors' institution by one surgeon between January 1992 and August 2003 were retrospectively reviewed.


RESULTS
Five (2%) of 235 patients developed an upper tract urothelial tumour. The mean follow-up for all patients was 42 months, and was 52.2 months for those with an upper tract tumour. Four of the five patients presented with haematuria and one was diagnosed on routine follow-up intravenous urography. The mean time to the diagnosis of an upper tract tumour was 39.6 months. Of the potential risk factors, only the presence of TCC of the prostatic urethra had a statistically significant association with eventual upper tract tumour (P < 0.01). At the last follow-up, four patients died from urothelial cancer and one was disease-free.


CONCLUSIONS
The incidence of upper tract tumour after cystectomy for TCC is low; most patients present with symptoms (haematuria) and have advanced disease at diagnosis. Patients with prostatic urethral involvement at cystectomy are at greater risk of developing upper tract tumour.
Department of Urology, University of Miami School of Medicine, Miami, FL, USA.
Paul D
PD
Sved
Pablo
P
Gomez
Alan M
AM
Nieder
Murugesan
M
Manoharan
Sandy S
SS
Kim
Mark S
MS
Soloway
D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000556:secondary* / Q000601:surgery; D015653:Cystectomy / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000556:secondary; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D014516:Ureteral Neoplasms / Q000556:secondary*; D001749:Urinary Bladder Neoplasms / Q000601:surgery*