Successful treatment of disseminated nonmeningeal coccidioidomycosis with voriconazole.
A 31-year-old Jamaican man with disseminated nonmeningeal coccidioidomycosis that involved the spine, ribs, pelvis, liver, and spleen did not clinically respond to a prolonged course of both amphotericin B deoxycholate and liposomal amphotericin B therapy. After institution of voriconazole monotherapy, the patient had a favorable (albeit slow) radiological and clinical response without adjunctive surgical intervention.
Prabhu
Rajesh M
RM
Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Bonnell
Mark
M
Currier
Bradford L
BL
Orenstein
Robert
R
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003047:Coccidioidomycosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole