Efficient and selective removal of methoxy protecting groups in carbohydrates.
[reaction: see text] The selective removal from carbohydrate substrates of methoxy protecting groups next to hydroxy groups is reported. On treatment with PhI(OAc)(2)-I(2), the methoxy group is transformed into an easily removable acetal. The mild conditions of this methodology are compatible with many functional groups, and good to excellent yields are usually achieved.
Boto
Alicia
A
Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez 3, 38206-La Laguna, Tenerife, Spain. alicia@ipna.csic.es
Hernández
Dácil
D
Hernández
Rosendo
R
Suárez
Ernesto
E
D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*
D002241:Carbohydrates