Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome.
No specific anatomic abnormalities have been detected in typical Landau-Kleffner syndrome (LKS), an acquired epileptic aphasia with language regression in children. In four children with typical LKS without obvious anatomic abnormalities, the authors performed MRI volumetric analysis of various neocortical regions and subcortical substructures. Volume reduction was detected in bilateral superior temporal areas (26 to 51%), specifically in planum temporale (25 to 63%) and superior temporal gyrus (25 to 57%), where receptive language is localized.
Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children's Hospital, 300 Longwood Ave., Hunnewell 2, Boston, MA 02115, USA. maxtakeoka@aol.com
M
M
Takeoka
J J
JJ
Riviello
F H
FH
Duffy
F
F
Kim
D N
DN
Kennedy
N
N
Makris
V S
VS
Caviness
G L
GL
Holmes
D001303:Auditory Cortex / Q000473:pathology; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D019579:Neocortex / Q000473:pathology; D009929:Organ Size; D013702:Temporal Lobe / Q000473:pathology