The use of bone marrow stem cells for bone tissue engineering.
Bone marrow stem cells (BMSC), known for its multipotency to differentiate into various mesenchymal cells such as chodrocyte, osteoblasts, adipocytes, etc, have been actively applied in tissue engineering. BMSC have been successfully isolated from bone marrow aspirate and bone marrow scraping from patients of various ages (13-56 years) with as little as 2ml to 5ml aspirate. BMSC isolated from our laboratory showed the presence of a heterogenous population that showed varying prevalence of surface antigens and the presence of telomerase activity albeit weak. Upon osteogenic induction, alkaline phosphatase activity and mineralization activity were observed.
Tissue Engineering Laboratory, Hospital Universiti Kebangsaan Malaysia.
M H Angela
MH
Ng
B S
BS
Aminuddin
K K
KK
Tan
G H
GH
Tan
M
M
Sabarul Afian
B H I
BH
Ruszymah
D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D019098:Telomerase / Q000378:metabolism; D023822:Tissue Engineering
D019098:Telomerase