Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla.
The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo-inositol measurement of 37%, compared with 6% for N-acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects.
Department of Radiology, University of California-San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California 94141, USA. lkaiser@itsa.ucsf.edu
Lana G
LG
Kaiser
Norbert
N
Schuff
Nathan
N
Cashdollar
Michael W
MW
Weiner
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D020772:Internal Capsule / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000378:metabolism*; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D014018:Tissue Distribution
D011522:Protons; C009217:scyllitol; D007294:Inositol