A case of atypical benign fibrous histiocytoma.
A case of atypical benign fibrous histiocytoma is reported. A 62-year-old Japanese female visited our clinic because of an asymptomatic solitary lesion on the skin of the left leg. Physical examination revealed a polypoid mass lesion (2.5 x 2.3 x 1.8 cm) with central erosion. The lesion began with a 1 mm-sized papule and slowly enlarged over the 20 years. Clinical diagnosis was a malignant tumor such as dermatofibrosarcoma protuberans, atypical fibroxanthoma or adnexal tumors. Biopsy of the polypoid lesion was carried out. Histopathological examination revealed a polypoid lesion consisting of proliferation of fibroblast-like spindle cells in the dermis. Large atypical cells with pleomorphic nuclei were occasionally observed but mitotic figures were rare. From immunohistochemical results (CD68, Factor-XIII, MIB-1 labeling index), we diagnosed this case as "atypical benign fibrous histiocytoma (ABFH)". Clear distinction has not been made between ABFH, a variant of benign fibrous histiocytoma, and atypical fibroxanthoma, which is a variant of malignant fibrous histiocytoma. Here we report a case of ABFH with a diagnosis of the neoplasm.
Ikoma
Norihiro
N
Department of Dermatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. n-ikoma@is.icc.u-tokai.ac.jp
Matsuyama
Takashi
T
Nuruki
Hiroko
H
Iizuka
Mariko
M
Umezawa
Yoshinori
Y
Ohta
Yukinori
Y
Ozawa
Akira
A
Sekido
Yasutomo
Y
Shimamura
Kazuo
K
Ueyama
Yoshito
Y
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D005176:Factor XIII / Q000032:analysis; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D007866:Leg; D008875:Middle Aged; D012867:Skin / Q000737:chemistry / Q000473:pathology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D005176:Factor XIII; D019394:Ki-67 Antigen; C067980:CD68 antigen, human; D000097382:CD68 Molecule