Neuroprotective effect of Ginkgo biloba L. extract in a rat model of Parkinson's disease.
The neuroprotective effects of a standardized extract of Ginkgo biloba L. (EGb 761) were investigated on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in the nigrostriatal dopaminergic system of the rat brain. Rats were given a week of pretreatment with daily administrations of EGb 761. Unilateral striatal injection of 6-OHDA was followed by treatment with EGb 761 for a week. Serial measurement of contralateral forepaw adjusting steps revealed a progressive deficit in motor activity. At 8 weeks after 6-OHDA lesion the number of contralateral forepaw adjusting steps was significantly higher in rats that were treated with high doses of EGb 761 (100 mg/kg daily) than in those treated with low doses (50 mg/kg) or with the vehicle. Dopamine neuron loss in the substantia nigra and a depletion in striatal dopamine corresponded with behavioural deficit. These data suggest that the neuroprotective effects of EGb 761 reduce the behavioural deficit in 6-OHDA lesions in rat and also indicates a possible role for the extract in the treatment of Parkinson's disease.
Department of Food and Nutrition, Catholic University, Puchon City, Kyonggi-Do, Korea.
M-S
MS
Kim
J-I
JI
Lee
W-Y
WY
Lee
S-E
SE
Kim
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000517:prevention & control*; D004195:Disease Models, Animal; D005684:Gait / Q000502:physiology; D020441:Ginkgo biloba; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016627:Oxidopamine; D010300:Parkinson Disease / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D000096983:Ginkgo Extract
D018696:Neuroprotective Agents; D016627:Oxidopamine; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract