Hotspots of homologous recombination in the human genome: not all homologous sequences are equal.
Homologous recombination between alleles or non-allelic paralogous sequences does not occur uniformly but is concentrated in 'hotspots' with high recombination rates. Recent studies of these hotspots show that they do not share common sequence motifs, but they do have other features in common.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. jlupski@sanger.ac.uk
James R
JR
Lupski
D000818:Animals; D015894:Genome, Human; D006801:Humans; D011995:Recombination, Genetic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid