[Antigenic activity of oral whole-culture meningococcal serogroup B vaccine].
The whole-culture vaccine preparation of Neisseria meningitidis, serogroup B, obtained by cultivation in a computer-controlled bioreactor, was studied. The preparation was shown to contain antigenically active polysaccharide, outer membrane proteins, as well as lipooligosaccharide, faintly pyrogenic and with low toxicity. After oral immunization of rabbits a multiple increase in the levels of IgG antibodies to these antigens in their blood serum was noted during the period of observation (303 days).
Aleksakhina
N N
NN
Basnak'ian
I A
IA
Kozlova
N N
NN
Verner
I K
IK
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D019149:Bioreactors; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007074:Immunoglobulin G / Q000097:blood; D008589:Meningococcal Infections / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage*; D051379:Mice; D038541:Neisseria meningitidis, Serogroup B / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology; D011817:Rabbits; D013997:Time Factors; D014611:Vaccination
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D007074:Immunoglobulin G; D022401:Meningococcal Vaccines; D011134:Polysaccharides