Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro.
We investigated the scavenging effects of tertiary selenoamide compounds for super oxide radicals using a highly sensitive and quantitative chemiluminescence method. At 333 nM, tertiary selenoamide compounds scavenged 25.8-81.6% of O(2)(-). N-(Phenylselenocarbonyl) piperidine was the most effective scavenger of superoxide radicals. While N,N-diethyl-2-selenonaphthylamide and N,N-diethyl-4-chloroselenobenzamide was a moderately effective scavenger of superoxide radicals. The IC(50) of N-(phenylselenocarbonyl) piperidine and N,N-diethyl-2-selenonaphthylamide were determined to be 110 and 182 nM, respectively. The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals.
Gunma Industrial Technology Center, 884-1 Kamesato, Maebashi, Gunma 379-2147, Japan.
Hitoe
H
Takahashi
Atsuyoshi
A
Nishina
Hirokazu
H
Kimura
Kenji
K
Motoki
Mamoru
M
Koketsu
Hideharu
H
Ishihara
D000577:Amides / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D008163:Luminescent Measurements; D016566:Organoselenium Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000737:chemistry*
D000577:Amides; D016166:Free Radical Scavengers; D016566:Organoselenium Compounds; D013481:Superoxides