Metabolic storage diseases: amyloidosis.
This article provides an overview of the current concepts in pathogenesis, epidemiology, clinical significance, and treatment options for amyloidosis. Emphasis is given to hepatic amyloidosis, which ranges from a clinically insignificant histologic curiosity to a harbinger of widespread disease accompanied by a poor prognosis. Clinical characteristics and clues to the diagnosis are discussed as well as the importance of histologic confirmation and the controversy surrounding liver biopsy.
Department of Pathology, Saint Louis University School of Medicine, 4(th) Floor, SLUH, 3635 Vista Avenue, St. Louis, MO 63110, USA. bruntem@slu.edu
Elizabeth M
EM
Brunt
Dina G
DG
Tiniakos
D000686:Amyloidosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D015994:Incidence; D008099:Liver / Q000473:pathology*; D011379:Prognosis