Primitive neuroectodermal tumor (PNET) of the uterus in a renal allograft patient: a case report.
The incidence of malignancy after renal transplant has been reported to range from 4% to 18%. Tumors of the skin and lip tend to be the most common with non-Hodgkin lymphoma comprising 20% of all neoplasms. Primitive neuroectodermal tumors (PNET) are collectively described as being a part of the Ewing sarcoma family of tumors. PNET occur more commonly in the second decade of life, predominantly affecting Whites and Hispanics, and rarely occur in individuals of African or Asian descent. The most common primary site of involvement is along the central axis, particularly the chest (Askin tumor), but it can arise in any soft tissue. PNET also occur in the head and neck. PNET involving the cervix, urinary bladder, uterus, and vagina have been reported. We describe a case of a 15-year-old female who, 9 years after receiving a living related renal transplant, developed a post-transplant PNET of the uterus.
Department of Pediatric Hematology/Oncology, Children's Hospital of Michigan and Wayne State University School of Medicine, Detroit, Michigan, USA. eperes@dmc.org
Edward
E
Peres
Tej K
TK
Mattoo
Janet
J
Poulik
Indira
I
Warrier
D000293:Adolescent; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D018242:Neuroectodermal Tumors, Primitive / Q000209:etiology*; D011183:Postoperative Complications; D014184:Transplantation, Homologous; D014594:Uterine Neoplasms / Q000209:etiology*