Genetic dissection of human stature in a large sample of multiplex pedigrees.
Recently, we reported a whole genome scan on a sample of 630 Caucasian subjects from 53 human pedigrees. Several genomic regions were suggested to be linked to height. In an attempt to confirm the identified genomic regions, as well as to identify new genomic regions linked to height, we conducted a whole genome linkage study on an extended sample of 1,816 subjects from 79 pedigrees, which includes the 53 pedigrees containing the original 630 subjects from our previous whole genome study and an additional 128 new subjects, and 26 further pedigrees containing 1,058 subjects. Several regions achieved suggestive linkage signals, such as 9q22.32 [MLS (multipoint LOD score) = 2.74], 9q34.3 [MLS = 2.66], Xq24 [two-point LOD score = 2.64 at the marker DXS8067], and 7p14.2 [MLS = 2.05]. The importance of the above regions is supported either by other whole genome studies or by candidate genes within these regions relevant to linear growth or pathogenesis of short stature. In addition, this study has tentatively confirmed the Xq24 region's linkage to height, as this region was also detected in the previous whole genome study. To date, our study has achieved the largest sample size in the field of genetic linkage studies of human height. Together with the findings of other studies, the current study has further delineated the genetic basis of human stature.
Osteoporosis Research Center, Creighton University, 601 N. 30th St. Suite 6787, Omaha, NE 68131, USA.
Yao-Zhong
YZ
Liu
Fu-Hua
FH
Xu
Hui
H
Shen
Yong-Jun
YJ
Liu
Lan-Juan
LJ
Zhao
Ji-Rong
JR
Long
Yuan-Yuan
YY
Zhang
Peng
P
Xiao
Dong-Hai
DH
Xiong
Volodymyr
V
Dvornyk
Jin-Long
JL
Li
Theresa
T
Conway
K Michael
KM
Davies
Robert R
RR
Recker
Hong-Wen
HW
Deng
D000328:Adult; D000368:Aged; D001827:Body Height / Q000235:genetics*; D002874:Chromosome Mapping; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D023281:Genomics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012016:Reference Values; D044465:White People / Q000235:genetics