Cytokine profile associated with human chronic schistosomiasis mansoni.
This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.
Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas s/no, 40110-160 Salvador, BA, Brazil.
Andréa
A
Magalhães
Delfin Gonzalez
DG
Miranda
Roberval Gonzalez
RG
Miranda
Maria Ilma
MI
Araújo
Adriana Almeida de
AA
Jesus
Angela
A
Silva
Luciana B
LB
Santana
Edward
E
Pearce
Edgar M
EM
Carvalho
Amélia Ribeiro de
AR
Jesus
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000276:immunology / Q000469:parasitology*; D008297:Male; D008875:Middle Aged; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000097:blood* / Q000276:immunology; D012720:Severity of Illness Index; D014463:Ultrasonography
D016207:Cytokines