Src family kinases, key regulators of signal transduction.
The Src family of protein tyrosine kinases (SFKs) plays key roles in regulating signal transduction by a diverse set of cell surface receptors in the context of a variety of cellular environments. SFKs have evolved many ingenious molecular strategies to couple receptors with the cytoplasmic signaling machinery. The contributions to this issue of ONCOGENE describe how this machinery regulates fundamental cellular processes, including cell growth, differentiation, cell shape, migration and survival, and specialized cell signals. The pleiotropic functions of Src and Src family members underscore the importance of these kinases and explain why many of the members of this family have been identified as cellular oncogenes. In this volume, we have attempted to provide the reader with an overview of the current understanding of the function of Src family kinases in the regulation of selected cellular signaling pathways.
Parsons
Sarah J
SJ
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908-0734, USA. sap@virginia.edu
Parsons
J Thomas
JT
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D019061:src-Family Kinases / Q000502:physiology*
D043562:Receptors, G-Protein-Coupled; D020794:Receptor Protein-Tyrosine Kinases; D019061:src-Family Kinases