Novel PEEK-WC membranes with low plasma protein affinity related to surface free energy parameters.
There has been growing interest in innovative materials with specific physico-chemical properties that provide an improved blood/cell compatibility. In this paper we evaluated the performance of new membranes prepared from a modified polyetheretherketone (PEEK-WC) contacting human plasma proteins. These membranes were prepared by using the phase inversion technique. Membrane wettability and affinity to proteins were evaluated by means of contact angle experiments, roughness measurements, and quantitative UV analysis. The energy parameters of membrane surfaces were determined according to Good, van Oss and Chaudhury's theory. The extent of human albumin, fibrinogen and immunoglobulin G adsorption was related to quantitative expressions of the membrane surface hydrophilicity: the base parameter of surface free energy and the free energy of interfacial interaction. The performance of PEEK-WC membranes was compared to that of commercial membranes, which conventionally are used in biomedical applications. The experimental results showed a reduction of protein adsorption on PEEK-WC membranes with respect to other commercial membranes. The low protein affinity of PEEK-WC membranes is due to the intrinsic physico-chemical characteristics of the polymeric material which makes these membranes interesting for potential use in biomedical applications.
Institute on Membrane Technology, National Research Council of Italy, ITM-CNR, c/o University of Calabria, via P. Bucci cubo 17/C, I-87030 Rende (CS), Italy. l.debartolo@itm.cnr.it.
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L
De Bartolo
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Gugliuzza
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S
Morelli
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B
Cirillo
A
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Gordano
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Drioli
D000327:Adsorption; D001577:Benzophenones; D001672:Biocompatible Materials / Q000737:chemistry*; D001798:Blood Proteins / Q000737:chemistry*; D006801:Humans; D007659:Ketones / Q000737:chemistry*; D008422:Materials Testing; D008567:Membranes, Artificial; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers; D011485:Protein Binding; D025941:Protein Interaction Mapping; D013223:Statistics as Topic; D013500:Surface Tension
D001577:Benzophenones; D001672:Biocompatible Materials; D001798:Blood Proteins; D007659:Ketones; D008567:Membranes, Artificial; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols