Movement of a novel serum tumour marker, RCAS1, in patients with biliary diseases.
BACKGROUND
We have demonstrated immunohistochemically that RCAS 1 antigen is expressed in biliary neoplasms. Serum RCAS 1 levels are also elevated in a high percentage of patients with intra-hepatic cholangiocarcinoma.


OBJECTIVE
The study was designed to determine whether serum levels of RCAS1 are of clinical significance as a tumour marker for biliary tract tumour, in comparison to CA19-9.


METHODS
In 38 patients with biliary carcinoma (gallbladder carcinoma, extra-hepatic and intra-hepatic cholangiocarcinoma and ampullary carcinoma), we measured serum RCAS1 and CA19-9 levels. For control, serum samples from patients with benign biliary disease and healthy volunteers were also examined.


RESULTS
We established a threshold value for RCAS1 of 17.5 U/ml, which permitted discrimination between malignant and non-malignant biliary diseases. In comparison to CA 19-9, serum RCAS1 was more sensitive and specific for malignancy, and was not influenced by cholestasis. RCAS1 levels varied with respect to the disease course and the effect of clinical treatment.


CONCLUSIONS
Serum RCAS1 appears to be valuable as a diagnostic index for biliary carcinomas, as well as for evaluating the progression of cancers during therapy. We speculate that RCAS1 is a clinically more significant serum marker for biliary neoplasms than CA19-9.
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. enjoji@intmed3.med.kyushu-u.ac.jp
M
M
Enjoji
K
K
Yamaguchi
M
M
Nakamuta
M
M
Nakashima
K
K
Kotoh
M
M
Tanaka
H
H
Nawata
T
T
Watanabe
D000951:Antigens, Neoplasm / Q000097:blood*; D017734:Bile Ducts, Extrahepatic / Q000473:pathology; D001661:Biliary Tract Neoplasms / Q000175:diagnosis* / Q000628:therapy; D014408:Biomarkers, Tumor / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000628:therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D011237:Predictive Value of Tests
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; C120762:EBAG9 protein, human; D005472:Fluorouracil