Intrauterine infection after delivery: a marker of HIV-1 seropositivity among puerperal women in Uganda?
A case controlled study about HIV seroprevalence among women with post-partum endometritis-myometritis (PPEM) matched with two controls. Each was performed in a non-governmental organization hospital in Kampala, Uganda. All participants were offered HIV pre- and post-test counselling. Personal and clinical information was obtained and HIV-1 ELISA tests performed on blood samples and discordant results resolved by Western blot test. HIV-1 seroprevalence was significantly higher among women with PPEM than controls, 26 (42.3%) and 26 (21.3%) respectively (P = 0.002). Women with PPEM were two-and-a-half times more likely to be HIV-positive than controls, odds ratio 2.74 (95% CI 1.34-5.65). Single or cohabiting women and low salaried women were also significantly more among PPEM cases than controls. In conclusion, PPEM cases had significantly higher seroprevalence of HIV-1 infection than controls and this needs further elucidation for purposes of management strategies.
Okong
P
P
Department of Obstetrics and Gynaecology, Nsambya Hospital, Kampala, Uganda.
Biryahwaho
B
B
Bergstrom
S
S
D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D004716:Endometritis / Q000150:complications*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D006679:HIV Seropositivity; D015528:HIV Seroprevalence; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D011247:Pregnancy; D011644:Puerperal Disorders / Q000150:complications*; D014454:Uganda / Q000453:epidemiology
D015415:Biomarkers; D015483:HIV Antibodies