Recurrent preeclampsia and perinatal outcome: a study of women with recurrent preeclampsia compared with women with preeclampsia who remained normotensive during their prior pregnancies.
OBJECTIVE
To evaluate the impact of preeclampsia recurrence on perinatal outcome.


METHODS
A case-controlled study was performed in multiparous women who developed preeclampsia in index pregnancy (n = 64). Among these, women who had preeclampsia in previous pregnancies (n = 21) were compared to those who remained normotensive during their prior pregnancies (n = 43). Maternal and fetal variables were compared. Multivariate logistic analyses were performed to examine the impact of preeclampsia recurrence on fetal loss, preterm delivery, small for gestational age (SGA) occurrence and respiratory distress syndrome adjusted for confounding variables.


RESULTS
No statistical significant difference was observed between the two groups in terms of age, delivery weeks, steroid use and laboratory markers. Fetal loss was higher in women with recurrent preeclampsia (19.0%) than in women with preeclampsia who had a normotensive pregnancy history (4.7%), with adjusted odds ratio (OR) of 5.77 [95% confidence interval (CI) 0.84-39.54].


CONCLUSIONS
Women with recurrent preeclampsia had a higher rate of perinatal loss compared to women with preeclampsia who were normotensive in their prior pregnancies.
Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Antalya, Turkey. imendilcioglu@hotmail.com
Inanc
I
Mendilcioglu
Bilal
B
Trak
Mine
M
Uner
Selda
S
Umit
Mesut
M
Kucukosmanoglu
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008499:Medical Records; D010298:Parity; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology