A nuclear strike against Listeria--the evolving life of LXR.
LXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control cholesterol efflux and inhibit the transcription factor NF-kappaB-mediated proinflammatory responses. In this issue of Cell, discover surprising, protective functions for LXRalpha in innate immunity.
Barish
Grant D
GD
Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Evans
Ronald M
RM
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004268:DNA-Binding Proteins; D007113:Immunity, Innate; D008087:Listeria / Q000276:immunology*; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D020033:Protein Isoforms / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000276:immunology*
D004268:DNA-Binding Proteins; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D020033:Protein Isoforms; D018160:Receptors, Cytoplasmic and Nuclear; D002784:Cholesterol