Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription.
Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[alpha-L-rhamnopyranosyl(1 --> 4)-beta-D-glucopyranosyl(1 --> 6)]-beta-D-glucopyranosyl] ester (3), and ursolic acid (4) by physicochemical and spectroscopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50: 12.65 microM).
Cai
Xing Fu
XF
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Lee
Im Seon
IS
Shen
Guanghai
G
Dat
Nguyen Tien
NT
Lee
Jung Joon
JJ
Kim
Young Ho
YH
D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D028001:Eleutherococcus; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C570594:3,11-dihydroxylup-20(29)-en-28-oic acid; D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D010936:Plant Extracts; D014157:Transcription Factors; D014315:Triterpenes