Inclusion of organ movements in IMRT treatment planning via inverse planning based on probability distributions.
In this paper, we investigate an off-line strategy to incorporate inter-fraction organ motion in IMRT treatment planning. It was suggested that inverse planning could be based on a probability distribution of patient geometries instead of a single snap shot. However, this concept is connected to two intrinsic problems: first, this probability distribution has to be estimated from only a few images; and second, the distribution is only sparsely sampled over the treatment course due to a finite number of fractions. In the current work, we develop new concepts of inverse planning which account for these two problems.
Unkelbach
J
J
Department of Medical Physics in Radiation Therapy, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. j.unkelbach@dkfz.de
Oelfke
U
U
D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D009068:Movement; D011336:Probability; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D013997:Time Factors; D014057:Tomography, X-Ray Computed