Assessment of cadmium impregnation in women suffering from endometriosis: a preliminary study.
Environmental chemicals with oestrogen-like activity are suspected aetiological factors of endometriosis. In animal experiments, cadmium was recently shown to possess oestrogen-like properties. In the frame of a case-control study designed to investigate environmental risk factors for endometriosis, we compared cadmium urinary excretion (CdU) and blood concentration in 59 patients with peritoneal endometriosis, deep endometriotic (adenomyotic) nodules of the recto-vaginal septum and controls. After standardisation for age (30 years) and smoking status, the mean levels of cadmium in urine were (geometric mean [geometric S.D.]) 0.25 [1.50], 0.29 [1.76] and 0.26 [1.46] microg/g creatinine, respectively. Cadmium concentrations in blood did not differ among the three groups. These data, therefore, do not support a role for cadmium in the onset or the growth of endometriosis or deep endometriotic (adenomyotic) nodules of the recto-vaginal septum.
Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Université catholique de Louvain, 30.54 Clos Chapelle aux Champs, B-1200 Brussels, Belgium. Jean-Francois.Heilier@toxi.ucl.ac.be
Jean-François
JF
Heilier
Violaine
V
Verougstraete
Fabienne
F
Nackers
René
R
Tonglet
Jacques
J
Donnez
Dominique
D
Lison
D000328:Adult; D001530:Belgium; D015415:Biomarkers / Q000032:analysis; D001822:Body Burden; D002104:Cadmium / Q000378:metabolism*; D016022:Case-Control Studies; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D010049:Ovarian Diseases / Q000378:metabolism* / Q000473:pathology
D015415:Biomarkers; D002104:Cadmium