Science review: extracellular acidosis and the immune response: clinical and physiologic implications.
Metabolic acidosis is among the most common abnormalities seen in patients suffering from critical illness. Its etiologies are multiple and treatment of the underlying condition is the mainstay of therapy. However, growing evidence suggests that acidosis itself has profound effects on the host, particularly in the area of immune function. Given the central importance of immune function to the outcome of critical illness, there is renewed interest in elucidating the effects of this all too common condition on the immune response. In this review we concentrate on the effects of extracellular acids on production and release of inflammatory mediators, and we demonstrate that different acids produce different effects despite similar extracellular pH. Finally, we discuss potential clinical implications.
Critical Care Medicine and Medicine, The Mechanisms And Novel Therapies for Resuscitation and Acute illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. kellumja@ccm.upmc.edu
John A
JA
Kellum
Mingchen
M
Song
Jinyou
J
Li
D000136:Acid-Base Equilibrium / Q000276:immunology*; D000138:Acidosis / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D016638:Critical Illness; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D005110:Extracellular Space / Q000737:chemistry*; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism*; D008262:Macrophage Activation / Q000276:immunology / Q000502:physiology; D009102:Multiple Organ Failure / Q000276:immunology; D016896:Treatment Outcome
D016207:Cytokines; D018836:Inflammation Mediators