Using functional genomics to improve productivity in the manufacture of industrial biochemicals.
Recent developments in the field of functional genomics have been used to increase productivity in the manufacture of industrial biochemicals. Technologies like transcriptomics and proteomics have profited from the increasing number of genome sequencing projects. Meanwhile functional genomics has evolved from several isolated technologies, such as DNA chip technology and proteomics, to combined approaches that can help us to understand why organisms produce a certain product. The combination of expression studies and kinetic studies, such as carbon flux determination or metabolite measurements, has significantly improved productivity in production processes.
Hermann
Thomas
T
Degussa AG, Feed Additives, Research and Development, Kantstrasse 2, 33790 Halle/Westfalen, Germany. thomas.hermann@degussa.com
D001419:Bacteria / Q000235:genetics*; D001709:Biotechnology / Q000379:methods; D002617:Chemical Industry; D015870:Gene Expression; D023281:Genomics; D007700:Kinetics; D040901:Proteomics; D014158:Transcription, Genetic