Cardiovascular disease in renal failure.
Cardiovascular disease is prevalent in patients with chronic kidney disease and may account for 50% of all deaths. Left ventricular hypertrophy is the most frequent cardiac alteration in end-stage renal disease (ESRD) patients. It is due to a combination of hemodynamic and humoral factors. Volume overload and pressure overload are responsible for adaptative alterations of the heart and the vessels consider as a unique functional system. These alterations are first beneficial but their persistence leads to a detrimental process, mainly cardiac dilation and failure. Treatment of the hemodynamic overload could partially stabilize or reverse this evolution.
Department of Nephrology, Manhes Hospital, Fleury-Merogis, France. alguerin@club-internet.fr
A P
AP
Guerin
H
H
Adda
G M
GM
London
S J
SJ
Marchais
D000740:Anemia / Q000209:etiology; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects; D005355:Fibrosis / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000150:complications*; D009206:Myocardium / Q000473:pathology; D018487:Ventricular Dysfunction, Left / Q000209:etiology