Acute megakaryoblastic leukemia with t(17;22)(q21;q13) and liver dysfunction.
The t(1;22)(p13;q13) is associated with acute megakaryoblastic leukemia (AMKL) seen mostly in young infants and known to have a poor prognosis. A 5-year-old child had prolonged prothrombin and partial thromboplastin times, low albumin, and decreased vitamin K-dependent coagulation factors and factor V activities at the time of AMKL diagnosis. All of these factors normalized following chemotherapy when remission was achieved. Cytogenetic analysis revealed a female karyotype with a balanced t(17;22)(q21;q13). Here, we present an AMKL pediatric case with a novel translocation and significant hepatocellular dysfunction that resolved with chemotherapy. The t(17;22) (q21;q13) may represent a variant of t(1;22)(p13;q13).
Children's Hospital of Michigan, Division of Hematology/Oncology, 3901 Beaubien Blvd., Detroit, MI 48201, USA.
Meera B
MB
Chitlur
Kanta
K
Bhambhani
Anwar N
AN
Mohamed
Yaddanapudi
Y
Ravindranath
Süreyya
S
Savaşan
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000188:drug therapy / Q000235:genetics*; D008107:Liver Diseases / Q000150:complications*; D014178:Translocation, Genetic