Interferon-gamma deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice.
Immunocompetent mice 129Sv (129) and C57BL/6 (B6) mice are similarly susceptible to Anaplasma phagocytophilum. We now show that 129 mice lacking interferon-gamma (IFN-gamma) develop more severe infection with A. phagocytophilum than IFN-gamma deficient B6 mice. These data demonstrate that there is an inherent increased susceptibility of 129 mice, compared with B6 mice, to A. phagocytophilum that can only be discerned in the absence of IFN-gamma.
Section of Rheumatology, Department of Internal Medicine, Yale University of School of Medicine, 300 Cedar Street, New Haven, CT, USA.
Tian
T
Wang
Mustafa
M
Akkoyunlu
Rila
R
Banerjee
Erol
E
Fikrig
D041081:Anaplasma phagocytophilum; D000818:Animals; D054426:Chemokine CXCL2; D018925:Chemokines / Q000032:analysis; D019743:Chemokines, CXC / Q000032:analysis; D004198:Disease Susceptibility; D016873:Ehrlichiosis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D005260:Female; D017353:Gene Deletion; D007371:Interferon-gamma / Q000235:genetics* / Q000276:immunology; D018664:Interleukin-12 / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D016897:Respiratory Burst
D054426:Chemokine CXCL2; D018925:Chemokines; D019743:Chemokines, CXC; C404915:Cxcl2 protein, mouse; D018664:Interleukin-12; D007371:Interferon-gamma