Vitamin E prevents deleterious effects of di (2-ethyl hexyl) phthalate, a plasticizer used in PVC blood storage bags.
Vitamin E administration prevented DEHP induced deleterious effects like (i) degenerative changes in the brain and thyroid, (ii) decrease in the activity of neuronal membrane Na+ - K+ ATPase, (iii) decrease in the concentration of insulin, cortisol and TSH, and (iv) the increase in T3 and T4 in female Albino rats. The results suggest use of vitamin E to prevent harmful effects of repeated transfusion of DEHP containing blood as in thalassemia patient. The possibility of using vitamin E to prevent the harmful effects of repeated transfusion of DEHP containing blood, as in thalassemia patients, is discussed.
Metabolic Disorders Research Center, Trivandrum 695014, India.
C R
CR
Dhanya
N S
NS
Gayathri
K
K
Mithra
K V Neelakantan
KV
Nair
P A
PA
Kurup
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001793:Blood Preservation / Q000379:methods*; D001803:Blood Transfusion / Q000379:methods*; D004051:Diethylhexyl Phthalate / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D010968:Plasticizers / Q000737:chemistry*; D011143:Polyvinyl Chloride / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism; D014810:Vitamin E / Q000627:therapeutic use*
D001786:Blood Glucose; D007328:Insulin; D010968:Plasticizers; D014810:Vitamin E; D013972:Thyrotropin; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate; D000254:Sodium-Potassium-Exchanging ATPase; D006854:Hydrocortisone