Mitochondrial poly(ADP-ribosylation): from old data to new perspectives.
Poly(ADP-ribosylation) is involved in DNA repair and replication, transcription, and cell death. For a long time, only one poly(ADP-ribosylating) enzyme was known, named ADPRT/PARP (EC 2.4.2.30). The recent discovery of a family of PARPs has provided a high degree of complexity in the field. Moreover, the finding that poly(ADP-ribosylation) is not confined to the nucleus but is also carried out by cytoplasmic enzymes supports the idea that it could regulate proteins localized in different cellular compartments. In this respect, a reappraisal of the literature on mitochondrial poly(ADP-ribosylation) could be useful, as well as a discussion of its relevance regarding the current "hot" view of poly(ADP-ribosylation) as a mediator of cell death.
Istituto di Genetica Molecolare CNR, Pavia, Italy. scovassi@igm.cnr.it
A Ivana
AI
Scovassi
D000818:Animals; D004260:DNA Repair; D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*
D009243:NAD; D011065:Poly(ADP-ribose) Polymerases