In search of the holy replicator.
After 40 years of searching for the eukaryotic replicator sequence, it is time to abandon the concept of 'the' replicator as a single genetic entity. Here I propose a 'relaxed replicon model' in which a positive initiator-replicator interaction is facilitated by a combination of several complex features of chromatin. An important question for the future is whether the positions of replication origins are simply a passive result of local chromatin structure or are actively localized to coordinate replication with other chromosomal activities.
Gilbert
David M
DM
Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NewYork 13210, USA. gilbertd@upstate.edu
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D004279:DNA, Viral; D005057:Eukaryotic Cells / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008957:Models, Genetic; D012093:Replicon
D004279:DNA, Viral; D004247:DNA