[Dopaminergic modulation of impulse activity of sensorymotor cortex neurons during conditioned reflex].
Changes of conditioned impulse reaction of cortical neurons wer studied during microiontophoretic application of agonist and antagonists of glutamate and GABA transmission and their modulation by dopamine. It was shown paradoxal reaction of facilitation of impulse activity during iontophoretic application of ionotropic glutamate antagonist and depressive influences of metabotropic antagonist. Local iontophoretic application of dopamine increased background and evoked impulse activity of pyramidal neurons of deep layers of cortex and eliminated inhibitory influences of glutamate metabotropic antagonist MCPG. It is concluded that DA has stabilizing effects on activity of cortical neurons. It is suppose that these effects of DA realize through system of inhibitory interneurons.
Storozhuk
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D000818:Animals; D002415:Cats; D003214:Conditioning, Classical; D004298:Dopamine / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D009044:Motor Cortex / Q000166:cytology / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D018755:GABA Agonists; D018756:GABA Antagonists; D004298:Dopamine