Developmental changes in dopamine modulation of the heart in the isopod crustacean Ligia exotica: reversal of chronotropic effect.
Developmental changes in dopamine modulation of the heart were examined in the isopod crustacean Ligia exotica. The Ligia cardiac pacemaker is transferred from the myocardium to the cardiac ganglion during juvenile development and the heartbeat changes from myogenic to neurogenic. In the myogenic heart of early juveniles, dopamine affected the myocardium and caused a decrease in the frequency and an increase in the duration of the myocardial action potential, resulting in negative chronotropic (decrease in beat frequency) and positive inotropic (increase in contractile force) effects on the heart. Contrastingly, in the heart of immature adults just after juvenile development, dopamine caused effects of adult type, positive chronotropic and positive inotropic effects on the heart affecting the cardiac ganglion and myocardium. During the middle and late juvenile stages, dopamine caused individually a negative or a positive chronotropic effect on the heart. These results suggest that the chronotropic effect of dopamine on the Ligia heart is reversed from negative to positive in association with the cardiac pacemaker transfer from the myocardium to the cardiac ganglion during juvenile development.
Yamagishi
Hiroshi
H
Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan. yamagashi@biol.tsukuba.ac.jp
Miyamoto
Hiroshi
H
Sakurai
Akira
A
D000200:Action Potentials; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004594:Electrophysiology; D005071:Evoked Potentials; D005260:Female; D017952:Ganglia, Invertebrate / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D006321:Heart / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D006329:Heart Conduction System / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D033321:Isopoda / Q000187:drug effects / Q000196:embryology / Q000254:growth & development*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000378:metabolism
D002316:Cardiotonic Agents; D004298:Dopamine