Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice.
The fragile histidine triad (FHIT) gene is frequently inactivated in various types of tumours. However, the system-wide pathology caused by FHIT inactivation has not been examined in detail. Here we demonstrate that Fhit gene knockout mice develop tumours in the lymphoid tissue, liver, uterus, testis, forestomach and small intestine, together with structural abnormalities in the small intestinal mucosa. These results suggest that Fhit plays important roles in systemic tumour suppression and in the integrity of mucosal structure of the intestines.
Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoé-cho, Sakyo-ku, Kyoto 606-8501, Japan.
T
T
Fujishita
Y
Y
Doi
M
M
Sonoshita
H
H
Hiai
M
M
Oshima
K
K
Huebner
C M
CM
Croce
M M
MM
Taketo
D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000818:Animals; D005260:Female; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D007414:Intestinal Neoplasms / Q000473:pathology*; D007421:Intestine, Small / Q000002:abnormalities / Q000473:pathology; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase