Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells.
T cell priming by dendritic cells (DC) from gut-associated lymphoid tissues gives rise to effector cells with pronounced gut tropism. The mechanism for DC-dependent imprinting of gut specificity has remained unknown. New findings point to retinoic acid, which is uniquely produced by intestinal DC, but not by DC from other lymphoid organs.
Mora
J Rodrigo
JR
The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
von Andrian
Ulrich H
UH
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003713:Dendritic Cells / Q000276:immunology; D004064:Digestive System / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology; D016201:Receptors, Lymphocyte Homing / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014212:Tretinoin / Q000494:pharmacology*
D000970:Antineoplastic Agents; D016201:Receptors, Lymphocyte Homing; D014212:Tretinoin