Highly regioselective nucleophilic carbon-carbon bond formation on furans and thiophenes initiated by pummerer-type reaction.
[reaction: see text] The reactions of (phenylsulfinyl)furans or -thiophenes with carbon nucleophiles in the presence of trifluoroacetic anhydride allowed the nucleophilic installation of carbon functional groups on the furan and thiophene nuclei with complete regioselectivity.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565-0871, Japan.
Shuji
S
Akai
Norihito
N
Kawashita
Hideharu
H
Satoh
Yasufumi
Y
Wada
Keisuke
K
Kakiguchi
Ikumi
I
Kuriwaki
Yasuyuki
Y
Kita