CT screening for lung cancer Assessing a regimen's diagnostic performance.
OBJECTIVE
The purpose of this study was to characterize the diagnostic performance of a regimen of CT screening for lung cancer.


METHODS
Using a common protocol/regimen of screening, 2968 asymptomatic persons at high risk for lung cancer were enrolled in two studies [Early Lung Cancer Action Projects (ELCAP) I and II] for baseline and annual repeat screening. A total of 4538 annual repeat screenings were performed. The regimen's diagnostic performance was characterized in terms of frequency of positive result of the initial CT as well as of screen-diagnosis and Stage I screen-diagnosis among all diagnoses (interim-diagnoses included), all separately for baseline and annual repeat screenings.


RESULTS
The proportions with positive result of the initial CT were 12% and 6% in the baseline and repeat screenings, respectively. The proportions of screen-diagnoses among all diagnoses (interim-diagnoses included) were 97% and 99% in the baseline and repeat cycles, respectively. The corresponding proportions of pre-surgical Stage I screen-diagnoses were 95% and 93%.


CONCLUSIONS
The performance of the ELCAP regimen is quite satisfactory in avoiding over many positive results of the initial CT, and it produces highly promising diagnostic results as for the attainment of cure by early intervention.
Henschke
Claudia I
CI
Department of Radiology, Weill Medical College of Cornell University, New York, NY 10021, USA. chensch@med.cornell.edu
Yankelevitz
David F
DF
Smith
James P
JP
Libby
Daniel
D
Pasmantier
Mark
M
McCauley
Dorothy
D
McGuinness
Georgeann
G
Naidich
David P
DP
Farooqi
Ali
A
Vasquez
Madeline
M
Miettinen
Olli S
OS
D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*