Is pulse pressure a predictor of cardiovascular complications in a frail elderly nursing home population?
OBJECTIVE
Previous studies have focused on systolic blood pressure (SBP), diastolic pressure (DBP), and more recently pulse pressure (PP) as risk factors for adverse cardiovascular (CV) endpoints in elderly people. However, the relation between these pressures and CV complications in the frail nursing home population has not been well studied. The aims of this project are to determine the value of PP in predicting CV complications in a nursing home population, and to compare its predictive value with SBP, DBP, and mean arterial pressure (MAP).


METHODS
This study is a retrospective 2-year review of the medical charts of 248 residents of the Hebrew Rehabilitation Center for the Aged, a long-term care facility in Boston, MA, USA. During the review process, data were collected about past medical history and new onset CV events, in addition to blood pressure and medication use.


RESULTS
The results showed, with 95% confidence, that within a 2-year period, the odds ratio for the occurrence of the selected CV outcomes (myocardial infarction, congestive heart failure, angina, stroke, renal failure, syncope, death) included 1.0 for PP, SBP, DBP, MAP, and changes in these values. After adjusting for medication use, pulse pressure was still not an independent risk factor for CV complications.


CONCLUSIONS
PP, SBP, DBP or MAP cannot serve as predictors of CV outcomes in the nursing home population. The presence of multiple medical problems in this frail population may have resulted in CV morbidity and mortality, independent of blood pressure effects.
Hebrew Rehabilitation Center For Aged Research and Training Institute, Boston, MA 02131, USA.
Morad
M
Askari
Dan K
DK
Kiely
Lewis A
LA
Lipsitz
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D009735:Nursing Homes / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D012307:Risk Factors