T-lymphocyte death during shutdown of an immune response.
The immune system serves to protect organisms from infectious pathogens. During infection, lymphocytes and cells of the innate immune system, expressing receptors that recognize foreign antigens, proliferate and differentiate to develop effector functions that help to kill the pathogens. Effector functions, such as cellular or antibody mediated cytotoxicity, and inflammatory cytokines can be harmful to the host. To limit damage to healthy tissue, mechanisms have evolved to shut down immune responses, including cell inactivation and cell death. Here we discuss recent studies demonstrating that the death of antigen-activated T lymphocytes during termination of an immune response is initiated by the BH3-only Bcl-2 family member Bim and also requires its multi-BH domain pro-apoptotic relatives Bax and Bak.
Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia. strasser@wehi.edu.au
Andreas
A
Strasser
Marc
M
Pellegrini
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D051017:Apoptosis Regulatory Proteins; D000072224:Bcl-2-Like Protein 11; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; C000606775:BCL2L11 protein, human; D000072224:Bcl-2-Like Protein 11; D002352:Carrier Proteins; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor