Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases.
The diagnosis of neurodegenerative diseases with dementias requires several different test approaches and often remains uncertain. Using a proteomic approach it was shown in nine patients that heart fatty acid binding protein (H-FABP) might be a biomarker for Creutzfeldt-Jakob disease (CJD). The aim of our study was to evaluate whether H-FABP is a biomarker for the differential diagnosis of dementias. Therefore we measured H-FABP in cerebrospinal fluid (CSF) and serum of patients having CJD, dementia with Lewy-bodies (DLB), Alzheimer's disease (AD) and in non-demented control (NDC) patients. H-FABP levels in CSF and serum of CJD patients are increased compared to non-demented controls. Levels of H-FABP were significantly higher in CJD patients compared to AD and DLB in CSF. However, discrimination between CJD and AD was not possible in serum. Interestingly, highest levels of H-FABP were found in serum of DLB patients. Our results suggest that H-FABP might be a useful biomarker for the differentiation between the dementias examined if levels in CSF and serum are determined in parallel.
Department of Neurology, University Hospital, Robert-Koch-Str. 40, 37075 Goettingen, Germany.
Petra
P
Steinacker
Brit
B
Mollenhauer
Mirko
M
Bibl
Lukas
L
Cepek
Hermann
H
Esselmann
Peter
P
Brechlin
Piotr
P
Lewczuk
Sigrid
S
Poser
Hans A
HA
Kretzschmar
Jens
J
Wiltfang
Claudia
C
Trenkwalder
Markus
M
Otto
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism; D015415:Biomarkers; D002352:Carrier Proteins / Q000097:blood* / Q000134:cerebrospinal fluid*; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D050556:Fatty Acid-Binding Proteins; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000378:metabolism; D018709:Statistics, Nonparametric
D015415:Biomarkers; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins