A suppression strategy for antibiotic discovery.
High-throughput phenotype screening and target identification have been combined in an effort to isolate antimicrobial, small-molecule therapeutics. This approach, developed by Brown and colleagues and reported in this issue, is a major technological advance for antimicrobial drug discovery.
Gaweska
Helena
H
Johnson Research Foundation, Department of Biochemistry and Biophysics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6059, USA.
Kielec
Joseph
J
McCafferty
Dewey
D
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods*
D000900:Anti-Bacterial Agents