Association of the M55L and Q192R paraoxonase gene polymorphisms with age-related macular degeneration.
OBJECTIVE
To investigate the reported association of the two single-nucleotide polymorphisms (SNPs) of the paraoxonase gene (PON1), Met-Leu 55 (M55L) and Gln-Arg 192 (Q192R), in individuals of Anglo-Celtic descent who have age-related macular degeneration (AMD).


METHODS
Case-control association study.


METHODS
Sixty-two individuals with late (end-stage) AMD and 115 control subjects (without AMD) were included in this study. The M55L and Q192R SNPs were amplified by polymerase chain reaction and genotyped, and statistical analysis was undertaken.


RESULTS
No association of either SNP was detected in persons of Anglo-Celtic descent who had AMD, although there was a significant difference in SNP allele frequency between Anglo-Celtic and Japanese individuals.


CONCLUSIONS
The M55L and Q192R SNPs of the PON1 gene do not appear to be associated with late AMD in individuals of Anglo-Celtic descent.
Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia. pnb@unimelb.edu.au <pnb@unimelb.edu.au>
Paul N
PN
Baird
Diep
D
Chu
Elizabeth
E
Guida
Hien T V
HT
Vu
Robyn
R
Guymer
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008268:Macular Degeneration / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014739:Victoria / Q000453:epidemiology
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human