Regression of rectal mucosa-associated lymphoid tissue lymphoma but persistence of Helicobacter pylori infection of gastric mucosa after administration of levofloxacin: report of a case.
OBJECTIVE
Several articles have reported regression of rectal lymphoma of mucosa-associated lymphoid tissue after anti- Helicobacter pylori therapy. It remains unclear, however, whether lymphoma of rectal mucosa-associated lymphoid tissue is related to Helicobacter pylori infection.


METHODS
A 60-year-old woman visited our hospital with a complaint of hematochezia. On colonoscopy a pale, ulcerated protrusion approximately 3.5 cm in diameter was found in the rectum. Pathologic diagnosis of a biopsy specimen was low-grade mucosa-associated lymphoid tissue lymphoma. The patient received a ten-day course of levofloxacin, and the cycle was repeated three times over seven months.


RESULTS
Although persistence of Helicobacter pylori infection was confirmed, the tumor regressed completely.


CONCLUSIONS
Our findings in this case suggest that rectal lymphoma of mucosa-associated lymphoid tissue may be related to unknown microorganisms other than Helicobacter pylori. Levofloxacin may be effective for treatment of rectal lymphoma of mucosa-associated lymphoid tissue regardless of Helicobacter pylori infection.
Dohden
Kenji
K
Department of Surgery, Fukui Prefectural Hospital, Fukui, Japan. kenji-d@mx1.fctu.ne.jp
Kaizaki
Yasuharu
Y
Hosokawa
Osamu
O
Hayashi
Hiroyuki
H
Hattori
Masakazu
M
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology*; D064704:Levofloxacin; D008223:Lymphoma / Q000188:drug therapy* / Q000382:microbiology*; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000382:microbiology*; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin