[Gene expression profiles in different tissues of human nasopharyngeal carcinoma].
OBJECTIVE
To screen the genes that may play an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC).


METHODS
Microdissection and cDNA genechip hybridization techniques were used to examine the differentially expressed genes in NPC tissue, the surrounding and adjacent tissues of NPC, and the nasopharyngeal inflammation tissue. The fluorescent signals on cDNA chip were scanned and the results of hybridization analyzed by image processing software.


RESULTS
Many differentially expressed genes were identified between the three samples, including many different types of genes, such as those responsible for signal and protein transmission, oncogene and tumor suppression genes, immune-associated genes, apoptosis genes and DNA binding and transcription factor genes.


CONCLUSIONS
The carcinogenesis of NPC involves many genes of a variety of types, suggesting its complex process.
Department of Pathology, Southern Medical University, Guangzhou 510515, China. hhxia@fimmu.com
Hui-xia
HX
Han
Lian-sheng
LS
Yao
Shuang
S
Wang
Wei-nong
WN
Han
Kai-tai
KT
Yao
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D018076:DNA, Complementary / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D009361:Neoplasm Invasiveness; D020411:Oligonucleotide Array Sequence Analysis
D018076:DNA, Complementary; D004273:DNA, Neoplasm