Micropuncture: unlocking the secrets of renal function.
This essay looks at the historical significance of five APS classic papers that are freely available online: Wearn JT and Richards AN. Observations on the composition of glomerular urine, with particular reference to the problem of reabsorption in the renal tubules. Am J Physiol 71: 209-227, 1924 (http://ajplegacy.physiology.org/cgi/reprint/71/1/209). Richards AN and Walker AM. Methods of collecting fluid from known regions of the renal tubules of Amphibia and of perfusing the lumen of a single tubule. Am J Physiol 118: 111-120, 1936 (http://ajplegacy.physiology.org/cgi/reprint/118/1/111). Walker AM and Hudson CL. The reabsorption of glucose from the renal tubule in Amphibia and the action of phlorhizin upon it. Am J Physiol 118: 130-143, 1936 (http://ajplegacy.physiology.org/cgi/reprint/118/1/130). Walker AM and Oliver J. Methods for the collection of fluid from single glomeruli and tubules of the mammalian kidney. Am J Physiol 134: 562-579, 1941 (http://ajplegacy.physiology.org/cgi/reprint/134/3/562). Walker AM, Bott PA, Oliver J, and MacDowell MC. The collection and analysis of fluid from single nephrons of the mammalian kidney. Am J Physiol 134: 580-595, 1941 (http://ajplegacy.physiology.org/cgi/reprint/134/3/580).
Emory University School of Medicine, Renal Division, WMRB Rm. 338, 1639 Pierce Drive NE, Atlanta, GA 30322, USA. jeff.sands@emory.edu
Jeff M
JM
Sands
D000042:Absorption; D000818:Animals; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006029:Glycosuria / Q000378:metabolism; D049673:History, 20th Century; D007678:Kidney Glomerulus / Q000502:physiology*; D007684:Kidney Tubules / Q000378:metabolism*; D010827:Physiology / Q000266:history*
D005947:Glucose