Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids.
Nipecotic acid derivatives bearing an aryl iminoxymethyl side chain at the position 6 were synthesised and tested for their GABA uptake inhibitory properties. Contrarily to the N-substituted derivatives 2, 3 the introduction of the oxime function in the side chain of analogues of the active nipecotic derivative 4 does neither increase, nor maintain the activity.
Faculté de pharmacie, UMR7081 du CNRS, laboratoire de pharmacochimie de la communication cellulaire, 74 route du Rhin, 67401 Illkirch, France.
Victor
V
N'goka
Tine B
TB
Stenbøl
Povl
P
Krogsgaard-Larsen
Gilbert
G
Schlewer
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D018682:GABA Agents / Q000138:chemical synthesis / Q000378:metabolism; D009557:Nipecotic Acids / Q000138:chemical synthesis* / Q000378:metabolism*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018682:GABA Agents; D009557:Nipecotic Acids; D005680:gamma-Aminobutyric Acid