Isothermal titration calorimetry studies on the binding of DNA bases and PNA base monomers to gold nanoparticles.
An isothermal titration calorimetric (ITC) investigation of the interaction of DNA bases and PNA base monomers with gold nanoparticles is described revealing a binding sequence in the order C > G > A > T. Direct measurement of the strength of interaction of ligands with nanogold by ITC has important implications in surface modification strategies for biomedical, catalysis, and nanoarchitecture applications.
Organic Chemistry (Synthesis) Division, National Chemical Laboratory, Pune 411 008, India.
A
A
Gourishankar
Sourabh
S
Shukla
Krishna N
KN
Ganesh
Murali
M
Sastry
D000225:Adenine / Q000737:chemistry*; D002151:Calorimetry; D003596:Cytosine / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013941:Thymine / Q000737:chemistry*
D020135:Peptide Nucleic Acids; D006147:Guanine; D006046:Gold; D003596:Cytosine; D000225:Adenine; D013941:Thymine