Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease.
BACKGROUND
Venous and arterial thromboses occur in patients with Behçet's disease and are associated with significant morbidity and mortality. Studies on a possible association between the occurrence of thrombosis and thrombophilia in patients with this disease have been controversial.


OBJECTIVE
To determine the prevalence of the most common thrombophilias and dyslipidaemia in patients with Behçet's disease with and without thrombosis.


METHODS
Blood samples from 107 patients with Behçet's disease who had or did not have thrombosis were analysed for factor V Leiden, prothrombin G20210A polymorphism, methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, factor VIII level, homocysteine and C reactive protein concentrations, dyslipidaemia, and plasma glucosylceramide.


RESULTS
There was no difference between patients with and without thrombosis in the prevalence of prothrombin G20210A polymorphism, factor V Leiden, homozygous MTHFR C677T, or plasma concentrations of homocysteine, C reactive protein, or glucosylceramide. In contrast, patients with thrombosis were found to have significantly higher mean levels of factor VIII, total cholesterol, triglycerides, VLDL cholesterol, and apolipoproteins B-100, C-II, and C-III than those without thrombosis. Multistepwise logistic regression analysis showed that triglyceride concentration was the best marker associated with thrombosis (p = 0.008), with an estimated odds ratio of 1.58 (95% confidence interval, 1.09 to 2.30) for a difference of 40 mg/dl.


CONCLUSIONS
Thrombophilia does not seem to play a major role in the tendency to thrombosis in Behçet's disease. However, dyslipidaemia, predominantly hypertriglyceridaemia, might be a risk factor.
Department of Medicine C, Sheba Medical Centre, Tel-Hashomer 52621, Israel.
M
M
Leiba
U
U
Seligsohn
Y
Y
Sidi
D
D
Harats
B A
BA
Sela
J H
JH
Griffin
A
A
Livneh
N
N
Rosenberg
I
I
Gelernter
H
H
Gur
M
M
Ehrenfeld
D000293:Adolescent; D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000032:analysis; D001528:Behcet Syndrome / Q000097:blood / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002784:Cholesterol / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D019851:Thrombophilia / Q000097:blood / Q000150:complications*; D013927:Thrombosis / Q000097:blood / Q000209:etiology*; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D015415:Biomarkers; D015243:Cholesterol, VLDL; D014280:Triglycerides; D005169:Factor VIII; D002784:Cholesterol