Peroxisome proliferator-activated receptor gamma: its role in metabolic syndrome.
Here we review PPARgamma function in relation to human adipogenesis, insulin sensitization, lipid metabolism, blood pressure regulation and prothrombotic state to perhaps provide justification for this nuclear receptor remaining a key therapeutic target for the continuing development of agents to treat human metabolic syndrome.
Pakala
Rajbabu
R
Cardiovascular Research Institute, Washington Hospital Center, 110 Irving Street NW, Suite 4B-1, Washington, DC 20010, USA.
Kuchulakanti
Pramod
P
Rha
Seung-Woon
SW
Cheneau
Edouard
E
Baffour
Richard
R
Waksman
Ron
R
D000273:Adipose Tissue / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007249:Inflammation / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000378:metabolism*; D047495:PPAR gamma / Q000187:drug effects / Q000502:physiology*; D011516:Prothrombin / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007004:Hypoglycemic Agents; D047495:PPAR gamma; D011516:Prothrombin