Experimental validation of the countercurrent model of urinary concentration.
This essay looks at the historical significance of four APS classic papers that are freely available online: Jolliffe N, Shannon JA, and Smith HW. The excretion of urine in the dog. III. The use of non-metabolized sugars in the measurement of the glomerular filtrate. Am J Physiol 100: 301-312, 1932 (http://ajplegacy.physiology.org/cgi/reprint/100/2/301). Shannon JA. The excretion of inulin by the dog. Am J Physiol 112: 405-413, 1935 (http://ajplegacy.physiology.org/cgi/reprint/112/3/405). Shannon JA and Fisher S. The renal tubular reabsorption of glucose in the normal dog. Am J Physiol 122: 765-774, 1938 (http://ajplegacy.physiology.org/cgi/reprint/122/3/765). Shannon JA, Farber S, and Troast L. The measurement of glucose Tm in the normal dog. Am J Physiol 133: 752-761, 1941 (http://ajplegacy.physiology.org/cgi/reprint/133/3/752).
Dept. of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Blvd., Rm. 834 MCLM, Birmingham, AL 35294-0005, USA. jschafer@uab.edu
James A
JA
Schafer
D000818:Animals; D004285:Dogs; D049673:History, 20th Century; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007671:Kidney Concentrating Ability / Q000502:physiology*; D010827:Physiology / Q000266:history*