Montelukast and airway remodeling in children with chronic persistent asthma: an open study.
We report a 4 yr follow up study of seven asthmatic children with chronic persistent asthma, high-residual volume and low-density areas at high-resolution computerized tomography after treatment with salmeterol and fluticasone. Improvement of lung function with disappearance of low-density areas in six patients after treatment with fluticasone and montelukast was obtained.
Department of Pediatrics, University of Pisa, Via Roma 67, 56100 Pisa, Italy. m.pifferi@med.unipi.it
Massimo
M
Pifferi
Davide
D
Caramella
Vincenzo
V
Ragazzo
Emanuela
E
De Marco
Angelo
A
Pietrobelli
Attilio L
AL
Boner
D000085:Acetates / Q000627:therapeutic use*; D000420:Albuterol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000730:Androstadienes / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D002908:Chronic Disease; D003521:Cyclopropanes; D004359:Drug Therapy, Combination; D000068298:Fluticasone; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000187:drug effects*; D011804:Quinolines / Q000627:therapeutic use*; D012129:Respiratory Function Tests; D000068299:Salmeterol Xinafoate; D013440:Sulfides
D000085:Acetates; D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; D000068299:Salmeterol Xinafoate; D000068298:Fluticasone; C093875:montelukast; D000420:Albuterol