Pbx genes are required in Xenopus lens development.
Development of the vertebrate eye is dependent on multiple tissue interactions and distinct sets of transcription factors and signalling molecules. The latter are thought to be FGF8 and BMP4, proteins secreted from the neural plate to induce lens formation in the overlying ectoderm. Here we show that the Pbx transcription factor plays a crucial role in this process, as it is required for FGF8 expression in the neural plate and is thus part of the complex hierarchy of genes involved in lens induction.
Department of Basic Medical Sciences, St. George's Hospital Medical School, London, UK. rmorgan@sghms.ac.uk
Richard
R
Morgan
Jastinder
J
Sohal
Mita
M
Paleja
Ruth
R
Pettengell
D000818:Animals; D001483:Base Sequence; D015153:Blotting, Western; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology*; D017931:DNA Primers / Q000737:chemistry; D004475:Ectoderm / Q000378:metabolism; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D005822:Genetic Vectors; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics; D017403:In Situ Hybridization; D007908:Lens, Crystalline / Q000196:embryology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D009432:Neural Crest / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism / Q000502:physiology*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011485:Protein Binding; D012313:RNA / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors; D014158:Transcription, Genetic; D014981:Xenopus; D029867:Xenopus Proteins
D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D017931:DNA Primers; C101121:HOXB1 homeodomain protein; C499813:HXP4 peptide; D018398:Homeodomain Proteins; D010455:Peptides; D029867:Xenopus Proteins; C525812:bmp4 protein, Xenopus; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors; D012313:RNA