Outcome after invasive recurrence in patients with ductal carcinoma in situ of the breast.
BACKGROUND
Local recurrence is used as a marker of treatment failure for patients with ductal carcinoma in situ (DCIS). As follow-up lengthens, distant recurrence, breast cancer-specific survival (BCSS), and overall survival must be monitored.


METHODS
A prospective database was used to analyze 1031 patients with DCIS. Patients having invasive recurrence after DCIS treatment were compared with patients having infiltrating ductal carcinoma (IDC). End points included distant recurrence, BCSS, and overall survival.


RESULTS
Overall, patients with DCIS had a BCSS of 99%. BCSS was 85% for patients with invasive recurrences. DDFS in this group was 80%. Stage I IDC patients had a BCSS of 91%, whereas it was 38% in those with stage I IDC and invasive recurrences.


CONCLUSIONS
Most patients with DCIS that recur can be salvaged. For the small subgroup of patients who recur with invasive breast cancer, survival is similar to that of patients with stage IIA IDC.
Breast Service, Department of Surgery and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave., No. 7415, Los Angeles, CA 90033, USA. melsilver9@aol.com
Lina
L
Romero
Laura
L
Klein
Wei
W
Ye
Dennis
D
Holmes
Rashida
R
Soni
Howard
H
Silberman
Michael D
MD
Lagios
Melvin J
MJ
Silverstein
D001943:Breast Neoplasms / Q000401:mortality*; D002278:Carcinoma in Situ / Q000401:mortality*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D011446:Prospective Studies; D015996:Survival Rate; D013997:Time Factors