Modified DNA analogues that sense light exposure with color changes.
We report the discovery of a new class of light-sensing molecules. These light sensors are composed of fluorophore oligomers assembled on a DNA backbone. A combinatorial library of tetrafluorophores consisting of over 14 000 compounds was synthesized and screened for rapid responses toward light exposure. Among the most light-sensitive molecules, at least three tetramers were found to respond to light exposure with apparent color changes, rather than simple photobleaching.
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
Jianmin
J
Gao
Soichiro
S
Watanabe
Eric T
ET
Kool
D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D003853:Deoxyribonucleosides / Q000138:chemical synthesis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry; D008027:Light; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects; D010777:Photochemistry; D013050:Spectrometry, Fluorescence / Q000379:methods*
D003853:Deoxyribonucleosides; D005456:Fluorescent Dyes; D006027:Glycosides; D009841:Oligonucleotides; D004247:DNA