Convenient magnesiation of aromatic and heterocyclic rings bearing a hydroxy group in presence of LiCl.
The reaction of various iodophenols with MeMgCl in presence of LiCl followed by the addition of i-PrMgCl provides the corresponding magnesiated magnesium phenolates as THF soluble reagents; this approach can be extended to heterocyclic compounds bearing a hydroxy group like pyridines and quinolines.
Kopp
Felix
F
Department Chemie, Ludwig-Maximilians-Universität München, Germany.
Krasovskiy
Arkady
A
Knochel
Paul
P