Roles of RecA homologues Rad51 and Dmc1 during meiotic recombination.
RecA protein is involved in homology search and strand exchange processes during recombination. Mitotic cells in eukaryotes express one RecA, Rad51, which is essential for the repair of double-strand breaks (DSBs). Additionally, meiotic cells induce the second RecA, Dmc1. Both Rad51 and Dmc1 are necessary to generate a crossover between homologous chromosomes, which ensures the segregation of the chromosomes at meiotic division I. It is largely unknown how the two RecAs cooperate during meiotic recombination. In this review, recent advances on our knowledge about the roles of Rad51 and Dmc1 during meiosis are summarized and discussed.
Shinohara
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A
Institute for Protein Research, Osaka University, Suita, Osaka, Japan. ashino@protein.osaka-u.ac.jp
Shinohara
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M
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D051135:Rad51 Recombinase; D011938:Rec A Recombinases; D011995:Recombination, Genetic / Q000502:physiology*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C495153:RAD51 protein, human; D051135:Rad51 Recombinase; D011938:Rec A Recombinases; C074556:DMC1 protein, human