Exposure to cobalt in the production of cobalt and cobalt compounds and its effect on the heart.
OBJECTIVE
To investigate whether exposure to cobalt in cobalt plants has any measurable effect on the cardiovascular system.


METHODS
Occupational, cross sectional study, using a self administered questionnaire, blood pressure measurement, electrocardiography, and laboratory tests in which 203 male workers with at least one year of exposure to cobalt and 94 unexposed controls participated. Echocardiography was performed on a subset of 122 most highly exposed cobalt workers, of which 109 were analysed, and on 60 controls, of which 57 were analysed. Analysis of covariance and a multiple regression analysis were used to evaluate the data.


RESULTS
Two of the echocardiography parameters measured were associated with cobalt exposure. In the higher exposure group the left ventricular isovolumic relaxation time (mean 53.3, 49.1, and 49.7 ms in the high exposure, low exposure, and control groups respectively) and the deceleration time of the velocity of the early rapid filling wave (mean 194.3, 180.5, and 171.7 ms for those in the high exposure, low exposure, and control groups respectively) were prolonged, indicating altered left ventricular relaxation and early filling.


CONCLUSIONS
Cumulative exposure to cobalt was found to be associated with the results of Doppler echocardiography measurements, indicating altered diastole. This finding supports the hypothesis that cobalt accumulation in the myocardium could affect myocardial function. Whether this finding has clinical implications remains to be evaluated.
Kokkola Zinc Oy, Kokkola, Finland. asko.linna@boliden.com
A
A
Linna
P
P
Oksa
K
K
Groundstroem
M
M
Halkosaari
P
P
Palmroos
S
S
Huikko
J
J
Uitti
D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry / Q000633:toxicity*; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005387:Finland; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000000981:diagnostic imaging
D003035:Cobalt