[Lovastatin effect on ergosterol production and growth of Tolypocladium inflatum 106].
The effect of lovastatin on Tolypocladium inflatum 106 was studied. The strain was shown to be highly sensitive to lovastatin when its MIC was determined by the agar diffusion method and under submerged conditions that was considered possible to use the strain as a test culture in screening of new natural compounds with hypolipidemic action and to study its specificity. It was demonstrated that the effect of lovastatin on ergosterol synthesis in T. inflatum 106 was of specific dose-dependent polymodal nature.
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Katlinskiĭ
D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004875:Ergosterol / Q000096:biosynthesis*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008148:Lovastatin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects* / Q000378:metabolism
D000960:Hypolipidemic Agents; D008148:Lovastatin; D004875:Ergosterol