In search of the holy replicator.
After 40 years of searching for the eukaryotic replicator sequence, it is time to abandon the concept of 'the' replicator as a single genetic entity. Here I propose a 'relaxed replicon model' in which a positive initiator-replicator interaction is facilitated by a combination of several complex features of chromatin. An important question for the future is whether the positions of replication origins are simply a passive result of local chromatin structure or are actively localized to coordinate replication with other chromosomal activities.
Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NewYork 13210, USA. gilbertd@upstate.edu
David M
DM
Gilbert
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D004279:DNA, Viral; D005057:Eukaryotic Cells / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008957:Models, Genetic; D012093:Replicon
D004279:DNA, Viral; D004247:DNA