Prior heat acclimation confers protection against noise-induced hearing loss.
Exposure to intense noise stress can cause a permanent noise-induced hearing loss which is thought to be due to elevation of reactive oxygen species in excess of the inherent antioxidant mechanisms of the cell. However, preconditioning to low levels of stress of one type can activate cellular mechanisms leading to the elevation of antioxidant levels so that the cell is then better able to tolerate subsequent severe stress of a different type. This has been called cross-tolerance. Here, we tested this hypothesis by acclimating rats to a moderate heat stress (30 days at 34 degrees C). The rats were exposed to 113 dB SPL noise for 3 days (12 h/day) in three different groups: heat acclimated then noise exposed; noise exposed and then heat acclimated; heat acclimated, then noise exposed and then heat acclimated again. Permanent changes in auditory function--auditory nerve brainstem evoked responses (ABR) and distortion product otoacoustic emissions (DPOAEs)--were evaluated in each of these animals and compared with those in rats exposed to noise only and in control groups of rats. Statistical evaluation of the results showed that when assessed with ABR, each of the heat-acclimated, noise-exposed groups was protected from the noise, even the group that was heat-acclimated after the noise exposure. When assessed with DPOAE, protection was statistically apparent only in the group that was heat acclimated, then exposed to noise, and not in the other groups. Thus, heat acclimation provides protection against permanent noise-induced hearing loss.
Department of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Ziv
Z
Paz
Sharon
S
Freeman
Michal
M
Horowitz
Haim
H
Sohmer
D000064:Acclimatization / Q000502:physiology*; D000818:Animals; D002470:Cell Survival / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D006198:Hair Cells, Auditory / Q000166:cytology / Q000502:physiology*; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology* / Q000517:prevention & control*; D006358:Hot Temperature; D008297:Male; D009622:Noise / Q000009:adverse effects; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains