[Efficacy of a complementary antiinflammatory treatment with erespal in chronic obstructive and nonobstructive bronchitis].
OBJECTIVE
To compare efficacy of atrovent alone and in combination with erespal in patients with chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD).


METHODS
Of 80 participants of the trial (51 male and 29 female--63.75 and 36.25%, respectively) who had CB or COPD, 39 patients (28 with CB and 11 with COPD) received 6-month combined treatment with erespal (160 mg/day) and atrovent (160 mcg/day) and 41 patients (32 with CB and 9 with COPD) received atrovent monotherapy in the same dosage.


RESULTS
Combined therapy produced positive changes in dyspnea, sputum characteristics and its discharge, cough, monotherapy improved sputum discharge and relieved cough; pulmonary ventilation improved in both groups especially in those on monotherapy. CB patients showed low cytosis, percentage and absolute count of neutrophils, absolute count of lymphocytes and eosinophils in induced sputum. In CB patients percentage of lymphocytes reduced while count of macrophages went up. Combined treatment including erespal also promoted a significant fall of serum and sputum TNFalpha and IL-8 reduction in the sputum.


CONCLUSIONS
Erespal+atrovent treatment proved more effective than atrovent alone. It is recommended for both CB and COPD patients without marked disorders of external respiration function.
L I
LI
Volkova
A A
AA
Budkova
N N
NN
Filonova
E I
EI
Khristoliubova
E B
EB
Kutuzova
N V
NV
Koroleva
T T
TT
Radzivil
Z R
ZR
Aminova
A G
AG
Chuchalin
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001772:Blood Cell Count; D029481:Bronchitis, Chronic / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D004221:Disulfiram / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D009241:Ipratropium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D013183:Sputum / Q000737:chemistry / Q000378:metabolism; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D009241:Ipratropium; D004221:Disulfiram