Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine.
Seven morphologists examined 382 slide and 82 non-slide, post-Chernobyl pediatric acute leukemia (AL) cases in radiation-exposed areas of Belarus, Russia and Ukraine; part of a case-control study by the International Consortium for Research on the Health Effects of Radiation. Among the slide cases, 99% were confirmed as AL: 92% acute lymphoid leukemia (ALL) and 86% acute myeloid leukemia (AMD demonstrating the utility of FAB classification for distinguishing ALL and AML. Among the non-slide cases, 79% were confirmed as AL: 84% ALL, and 71% AML. This study affirms AL diagnostic accuracy during a time of social upheaval in the former Soviet Union.
McCarthy
Philip L
PL
Department of Medicine, Blood and Marrow Transplant Section, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. philip.mccarthy@roswellpark.org
Paltiel
Ora
O
Maslova
Elena
E
Kulikov
Sergei
S
Hahn
Theresa
T
Kopecky
Kenneth J
KJ
Drozdova
Vera
V
Shmatina
Natalya
N
Tichonova
Ludmilla
L
Van Hoff
Jack
J
Gavrilova
Inna
I
Weinstein
Howard
H
D000208:Acute Disease; D016022:Case-Control Studies; D047852:Chernobyl Nuclear Accident; D019937:Diagnostic Techniques and Procedures / Q000592:standards; D006652:Histological Techniques / Q000592:standards; D006801:Humans; D007938:Leukemia / Q000145:classification* / Q000175:diagnosis*; D015203:Reproducibility of Results; D002094:Republic of Belarus; D012426:Russia; D014455:Ukraine