PPARgamma signaling: one size fits all?
Outcome of PPARgamma activation in cancer cells is not one-dimensional. PPARgamma signaling is dependent upon PPARgamma ligand affinity and binding characteristics, target cell context and interacting signaling networks.
Jain
Anjali
A
Louis Warschaw Prostate Cancer Center, Cedars-Sinai Prostate Cancer Center, Los Angeles, California 90048, USA.
Agus
David B
DB
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008024:Ligands; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D008024:Ligands; D047495:PPAR gamma