Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line.
OBJECTIVE
To determine whether 2-(3-carboxy-1-oxopropy1) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109.


METHODS
Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazolium-based colorimetric assay (MTT assay).


RESULTS
COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximum inhibition rate was 83.75%.


CONCLUSIONS
COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy.
Wu
Jing
J
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Gansu Province, China. wujing36@163.com
Lu
Hong
H
Zhou
Yun
Y
Qiao
Liang
L
Ji
Rui
R
Wang
Ai-Qing
AQ
Liu
Wei-Min
WM
Xue
Qun-Ji
QJ
D000970:Antineoplastic Agents / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004938:Esophageal Neoplasms; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans
C495189:2-(3-carboxy-1-oxopropyl)amino-2-deoxy-D-glucose; D000970:Antineoplastic Agents; D003847:Deoxyglucose; D005947:Glucose