[Lung transplantation. Possibilities and limitations].
Lung transplantation is an option for patients with endstage pulmonary diseases without contraindications. Recent European studies showed a survival benefit for patients with cystic fibrosis, fibrosis and emphysema after lung transplantation. Early mortality has been reduced recently by surgical improvements. Life expectancy after lung transplantation has improved in recent years but is still lower than in patients with other solid organ transplantations. Quality of life is consistently improved but exercise tolerance keeps reduced in comparison to the normal population. Specific problems described in detail are frequent organ rejections and infections, airway problems and a high incidence of malignant diseases. 5-year survival after lung transplantation is in average 60%.
Gottlieb
J
J
Abteilung Pneumologie, Medizinische Hochschule Hannover. gottlieb.jens@mh-hannover.de
Welte
T
T
Höper
M M
MM
Strüber
M
M
Niedermeyer
J
J
D015897:Comorbidity; D005060:Europe / Q000453:epidemiology; D006084:Graft Rejection / Q000401:mortality*; D006801:Humans; D008171:Lung Diseases / Q000401:mortality* / Q000601:surgery*; D016040:Lung Transplantation / Q000401:mortality*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome