Granulomatous diseases in a patient with cystic fibrosis.
We report the case of an adult with Crohn's disease and pulmonary sarcoidosis on the background of cystic fibrosis (CF). There is a recognized association between Crohn's colitis and CF, but cases of pulmonary sarcoidosis in CF are rare. There may be a pathogenic link between the two granulomatous disorders and CF with chronic immune stimulation leading to hyperimmunoglobulinemia, circulating immune complexes and subsequent granuloma formation.
Department of Respiratory Medicine, E 11 South, Royal Prince Alfred Hospital, Missenden Road, Camperdown NSW 2050, Australia.
Catherine J
CJ
Dobbin
Carmel
C
Moriarty
Peter T P
PT
Bye
D000328:Adult; D016956:Burkholderia cepacia / Q000302:isolation & purification; D003424:Crohn Disease / Q000150:complications*; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D017565:Sarcoidosis, Pulmonary / Q000150:complications*