Crossreactive antigens between life cycle stages of plasmodium falciparum.
The high mortality and morbidity induced by falciparum malaria has motivated research to find an efficient antimalarial vaccine. The parasite has a complex life cycle, both in the mosquito and human hosts, and presents a number of potential targets for vaccine-induced immune attack. Here, Inge Moelans and John Schoenmakers discuss how the search for protective antigens has been complicated by the discovery of multiple crossreactivities between different parasite proteins.
Department of Molecular Biology, University of Nijmegen, 6525 ED Nijmegen, The Netherlands.
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Moelans
J G
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Schoenmakers