Large duodenal somatostatinoma in the third portion associated with severe glucose intolerance.
A 51-year-old man was admitted with hyperglycemia and a duodenal tumor. Although his glycemic control was poor, basal C-peptide levels were not suppressed. Further examination revealed a mass measuring 7.8 cm in diameter in the third portion of the duodenum. Duodenectomy revealed a slow-growing sessile tumor located near Treitz's ligament. The immunohistochemical profile of sections of the specimen revealed the presence of somatostatin. The patient's serum somatostatin was elevated to 300 pg/ml preoperatively, but was reduced to 10 pg/ml postoperatively. Glycemic control also normalized after the operation.
Kimura
Ryosuke
R
Department of Internal Medicine, Kariya General Hospital, 5-15 Sumiyoshi-cho Kariya, Aichi 448-8505.
Hayashi
Yoshinari
Y
Takeuchi
Toyo
T
Shimizu
Manabu
M
Hiratsuka
Maki
M
Yoshida
Michihiro
M
Hamajima
Eiji
E
Iwata
Masaru
M
Imoto
Masami
M
Hattori
Hideo
H
D013505:Digestive System Surgical Procedures / Q000379:methods; D004379:Duodenal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery; D018149:Glucose Intolerance / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013004:Somatostatin / Q000097:blood; D013005:Somatostatinoma / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery
D013004:Somatostatin