The role of integrins in tumor angiogenesis.
Integrins are cell adhesion molecules that play an important role in the regulation of angiogenesis. In this overview, the vascular integrins and their mechanisms of action are outlined. Integrins have been evaluated in preclinical and clinical studies for the treatment of cancer and as diagnostic markers of angiogenesis. Furthermore, integrins are the basis for targeted therapy for solid tumors and novel imaging techniques to assess the angiogenic response of tumors.
Hwang
Rosa
R
Department of Surgery, University of California San Diego, Moores Comprehensive Cancer Center, 9500 Gilman Drive, La Jolla, CA 92093-0987, USA.
Varner
Judy
J
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D016023:Integrins / Q000502:physiology*; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000503:physiopathology*
D020533:Angiogenesis Inhibitors; D016023:Integrins