Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana.
By bioassay-guided separation, an already known saponin, Pulsatilla saponin D was isolated from the root of Pulsatilla koreana Nakai as a antitumor component when evaluated by in vivo antitumor activity as well as in vitro cytotoxic activity test. It showed potent inhibition rate of tumor growth (IR, 82%) at the dose of 6.4 mg/kg on the BDF1 mice bearing LLC cells.
SB Pharmaceutical Co. LTD, 533-2 Bonggok-ri, Banpo-myeon, Gongju-shi 314-923, Chungnam, Korea.
Yong
Y
Kim
Seong-Cheol
SC
Bang
Ji-Hyun
JH
Lee
Byung-Zun
BZ
Ahn
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D018517:Plant Roots; D031946:Pulsatilla; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins