Downstream processing of recombinant proteins from transgenic feedstock.
The search for inexpensive production systems capable of producing large quantities of recombinant protein has resulted in the development of new technology platforms based on transgenic plants and animals. Over the past decade, these transgenic systems have been used to produce several products and potential therapeutic proteins. Improvements continue to be made, not only in how the proteins are expressed but also in how the end products are obtained. As improvements in expression are realized, cost-saving measures will increasingly focus on downstream processing.
Department of Biological and Agricultural Engineering, Texas A&M University, MS 2117, College Station 77843, USA. znikolov@tamu.edu
Zivko L
ZL
Nikolov
Susan L
SL
Woodard
D000818:Animals; D030801:Animals, Genetically Modified / Q000378:metabolism; D001709:Biotechnology / Q000379:methods*; D030821:Plants, Genetically Modified / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000627:therapeutic use
D011994:Recombinant Proteins