Association of intracellular proteins with folded major histocompatibility complex class I molecules.
The major histocompatibility complex (MHC) class I molecule is responsible for presenting peptide antigens at the cell surface for recognition by cytotoxic T lymphocytes. Several chaperone molecules interact with the MHC class I heavy chain and release when the MHC groove folds around peptide. Two additional proteins, invariant chain and amyloid precursor-like protein 2 (APLP2), interact specifically and stably with MHC class I molecules that have folded peptide-binding grooves. Invariant chain and APLP2 also affect MHC class I cell-surface expression, and so may play a part in MHC class I trafficking. Association of APLP2 with the MHC class I molecule appears to be regulated by a viral protein, the adenovirus E3/19K protein. Analysis of the interactions of these proteins with each other and with MHC class I will clarify how presentation of antigens by MHC class I is controlled by events that occur subsequent to MHC class I folding.
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.
Chantey R
CR
Morris
Adrian J
AJ
Reber
Jason L
JL
Petersen
Shanna E
SE
Vargas
Joyce C
JC
Solheim
D000256:Adenoviridae / Q000276:immunology; D017503:Adenovirus E3 Proteins / Q000276:immunology*; D016564:Amyloid beta-Protein Precursor / Q000276:immunology*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000821:virology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000276:immunology*; D017510:Protein Folding; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
C084104:APLP2 protein, human; D017503:Adenovirus E3 Proteins; D016564:Amyloid beta-Protein Precursor; C492952:Aplp2 protein, mouse; D015395:Histocompatibility Antigens Class I; D009419:Nerve Tissue Proteins