Are antibodies important in mice infected with Plasmodium yoelii?
It is unwise to extrapolate results, even from one mouse strain to another, when attempting to define the mechanisms that control and effect anti-malaria immunity. It is important to better characterize the broad range o f possible responses that are likely to occur when individuals in an outbred population are infected. Here, Peter Sayles and Donald Wossom discuss briefly their views on the role of antibody in murine and human malaria infections, based on their work on mice infected with Plasmodium yoelii.
Sayles
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Department of Medical Microbiology and Immunology School of Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Wassom
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DL