Cytogenetic findings in phyllodes tumor and fibroadenomas of the breast.
The cytogenetic data on fibroadenomas and cystosarcoma phyllodes tumor of the breast, which are both biphasic breast tumors composed of epithelial and stromal components, are quite limited. In this study, we report on clonal chromosomal alterations in three fibroadenomas and one cystosarcoma phyllodes analyzed by GTG banding. The fibroadenomas presented mostly numerical abnormalities involving chromosomes 16, 18, and 21. One case presented a deletion on 17p. The cystosarcoma phyllodes presented numerous numerical abnormalities, mostly chromosome gains, and several marker chromosomes.
Departamento de Genética, Universidade Federal do Paraná, Centro Politécnico, Jardim das Américas, Curitiba, Paraná, Brazil, 80.000.
Miriam L
ML
Barbosa
Enilze M S F
EM
Ribeiro
Guaracira F
GF
Silva
Marcos E
ME
Maciel
Rubens S
RS
Lima
Luciane R
LR
Cavalli
Iglenir J
IJ
Cavalli
D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D005260:Female; D018226:Fibroadenoma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D003557:Phyllodes Tumor / Q000235:genetics*