The role of the medicinal chemist in drug discovery--then and now.
The role of the medicinal chemist in drug discovery has undergone major changes in the past 25 years, mainly because of the introduction of technologies such as combinatorial chemistry and structure-based drug design. As medicinal chemists with more than 50 years of combined experience spanning the past four decades, we discuss this changing role using examples from our own and others' experience. This historical perspective could provide insights in to how to improve the current model for drug discovery by helping the medicinal chemist regain the creative role that contributed to past successes.
Jlombardin@aol.com
Joseph G
JG
Lombardino
John A
JA
Lowe
D002626:Chemistry, Pharmaceutical / Q000266:history* / Q000379:methods / Q000639:trends; D015195:Drug Design; D005060:Europe; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D017056:Medical Laboratory Personnel / Q000266:history* / Q000639:trends*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000266:history*; D014481:United States
D004364:Pharmaceutical Preparations