[Immunoregulation of the population of intestinal gram-negative microflora].
The authors present summarized data obtained in their studies on the presence of close feedback relationship between the state of immunity to common antigenic determinants of lipopolysaccharides (LPS), localized on the cell-wall surface of Gram-negative bacteria, and the development of intestinal dysbacteriosis. The problems dealing with the regulation of the amount of intestinal microflora with immunity factors taking part in the mechanism of such regulation are discussed and analyzed. The state of immunity to common antigenic determinants of LPS of Gram-negative bacteria re-flects, seemingly, the total resistance level of the body, i.e. the functional state of the immune system as a whole. The suggestion has been made that the development of intestinal dysbacteriosis may be basically caused by functional disturbances of the immune system, induced by different exogenous and endogenous damaging factors.
V M
VM
Bondarenko
V G
VG
Likhoded
A A
AA
Vorob'ev
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D015169:Colony Count, Microbial; D006090:Gram-Negative Bacteria / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007107:Immune System; D007410:Intestinal Diseases / Q000097:blood / Q000276:immunology* / Q000382:microbiology*; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice
D000907:Antibodies, Bacterial; D008070:Lipopolysaccharides; C085483:Re lipopolysaccharide