An extremely active catalyst for the Negishi cross-coupling reaction.
A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (tri- and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.
Milne
Jacqueline E
JE
Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Buchwald
Stephen L
SL
D001713:Biphenyl Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
D001713:Biphenyl Compounds; D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D010165:Palladium