Caveolae meet endosomes: a stable relationship?
The endocytic trafficking of caveolae has been the subject of some controversy for many years. A new study (Pelkmans et al.) shows that budded caveolae can interact with both the caveosome and the early endosome and that caveolin-enriched regions of the early endosomal membrane form unusually stable domains that can incorporate cargo in a regulated manner.
Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Queensland 4072, Australia.
Robert G
RG
Parton
D021941:Caveolae / Q000378:metabolism*; D004705:Endocytosis; D011992:Endosomes / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D017434:Protein Structure, Tertiary