Regulation of gene expression in parasitic flatworms.
Transcriptional regulation and the role of transcription factors are widely regarded to be the major contributors controlling gene expression in eucaryotes. Translational control is less well understood due to the complexity of the components involved in regulation of protein synthesis at this level. Nevertheless, considerable advances have been made recently in elucidating the major controlling factors within the messenger RNA (mRNA) sequence and the translation machinery. In this article, Ron Podesta and Afzal Siddiqui suggest that protein synthesis in flatworm parasites is controlled post-transcriptionally and that these intracellular regulatory mechanisms are activated/suppressed by effectors of the host's immune response.
Department of Zoology, University of Western Ontario, London, Canada.
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Podesta
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Siddiqui