Ingestive behaviors and metabolic fuels after central injections of 5-HT1A and 5-HT1D/1B receptors agonists in the pigeon.
The effects of intracerebroventricular injections of 8-OH-DPAT (a 5-HT1A agonist; 3, 15 or 30 nmol) or GR46611 (a 5-HT1B/1D agonist; 3, 15 or 30 nmol) on feeding, drinking, preening and sleep-like behaviors were investigated in free-feeding (FF) pigeons. The effects of these 5-HT agonists on blood glucose and free fatty acids levels were also examined. Injections of 8-OH-DPAT evoked intense lipolytic and dipsogenic effects, but failed to affect feeding, non-ingestive behaviors and glycemic levels. On the other hand, GR46611 evoked significant increases in food intake (at the higher dose), as well as lipolytic and hyperglycemic effects, but left drinking and other non-ingestive behaviors unchanged. These effects are opposed to those found in rodents, and may be associated with the diverse, species-specific nature and distribution of these receptors, underscoring the need to examine the functional aspects of the 5-HT1 receptor family in a more extensive range of non-rodent species.
Department of Physiological Sciences, CCB, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
Renata A
RA
Da Silva
Silvana Tomazoni
ST
de Oliveira
Luciane P N
LP
Hackl
Caroline Inacio
CI
Spilere
Moacir Serralvo
MS
Faria
José
J
Marino-Neto
Marta A
MA
Paschoalini
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000178:Acrylamides / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D010856:Columbidae; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
D000178:Acrylamides; D001786:Blood Glucose; D005227:Fatty Acids; C119994:GR 46611; D007211:Indoles; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin