Reduction in neutrophil elastase concentration by recombinant alphal-antitrypsin (recAAT) does not alter bacterial loading in the sputum of cystic fibrosis patients.
Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Northern Ireland, UK. jemoore@niphl.dnet.co.uk
J E
JE
Moore
A
A
Shaw
B C
BC
Millar
S L
SL
Martin
P G
PG
Murphy
D G
DG
Downey
M
M
Ennis
J S
JS
Elborn
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D015169:Colony Count, Microbial / Q000379:methods; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D019272:Leukocyte Elastase / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology; D011994:Recombinant Proteins / Q000627:therapeutic use; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use*; D013183:Sputum / Q000382:microbiology*; D000515:alpha 1-Antitrypsin / Q000627:therapeutic use*
D011994:Recombinant Proteins; D015842:Serine Proteinase Inhibitors; D000515:alpha 1-Antitrypsin; D019272:Leukocyte Elastase