Established cell lines used in cystic fibrosis research.
The development of immortalized cell lines has been a significant benefit to the study of human disease, due to limitations in using primary cells and the availability of tissue. The immortalization of cells from cystic fibrosis (CF) patients as well as cells from non-CF individuals from tissues relevant to CF has been critical to enhancing our understanding of the physiological, biochemical and genetic mechanisms underlying CF and for the development of therapeutic strategies designed to manage CF pathology. A comprehensive list of immortalized cells from various tissue and species, with an emphasis on epithelial cells, is presented and discussed here.
California Pacific Medical Center Research Institute, San Francisco, CA, USA. dieter@cooper.cpmc.org
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Gruenert
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Willems
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Cassiman
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Frizzell
D000818:Animals; D001402:B-Lymphocytes; D002460:Cell Line; D003550:Cystic Fibrosis; D004847:Epithelial Cells; D004854:Herpesvirus 4, Human; D006801:Humans; D020545:Respiratory Mucosa; D014161:Transduction, Genetic