Effect of intraocular lenses on preventing posterior capsule opacification: design versus material.
OBJECTIVE
To compare the preventive effect of 4 types of design- and material-matched intraocular lenses (IOLs) on posterior capsule opacification (PCO).


METHODS
Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.


METHODS
After phacoemulsification, 1 of 2 matched IOLs in 3 groups was implanted in 1 eye and the other IOL in the contralateral eye of 4 to 6 rabbits. Three weeks postoperatively, posterior view and histopathological evaluations were performed and the capsular bending effect and amount of PCO evaluated.


RESULTS
The capsular bending effect was similar between a sharp-edged acrylic IOL (Sensar 40e, AMO) and a sharp-edged silicone IOL (ClariFlex, AMO) and between the Sensar 40e IOL and a sharp-edged acrylic IOL (AcrySof, Alcon Laboratories). There was no significant difference between IOL types in the amount of PCO. The capsular bend effect was slightly better and the PCO amount slightly less with the ClariFlex IOL than with the round-edged silicone PhacoFlex II IOL (AMO).


CONCLUSIONS
There was no substantial difference in PCO prevention between IOLs with sharp posterior optic edges, regardless of the IOL's material composition. The anterior edge design appeared to have no preventive effect. These results confirm that a sharp posterior optic edge is the main factor in preventing PCO.
Nishi
Okihiro
O
Nishi Eye Hospital, Tokyo, Japan. okihiro@nishi-ganka.or.jp
Nishi
Kayo
K
Osakabe
Yashuhiro
Y
D000180:Acrylic Resins; D000818:Animals; D001672:Biocompatible Materials; D002386:Cataract / Q000517:prevention & control*; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D018918:Phacoemulsification; D011183:Postoperative Complications / Q000517:prevention & control*; D011474:Prosthesis Design; D011817:Rabbits; D012826:Silicone Elastomers
D000180:Acrylic Resins; D001672:Biocompatible Materials; D012826:Silicone Elastomers