The surface-mosaic model in host-parasite relationships.
The dynamics of protein adsorption to a microbial surface could be of significance in host-parasite relationships because non-defense proteins might interfere with the binding of defense proteins. A surface mosaic of defense and non-defense proteins formed on the microbial surface could activate one of the tissue reactivity programs via a binary code (help or silence) generated by the adsorbed proteins. Understanding the mechanisms of the mosaic formation and its evolution might help to identify evasion mechanisms used by virulent microorganisms. This also provides a conceptual framework to design new strategies to control the infectious diseases they cause.
Department of Microbiology, Immunology and Pathology, Colorado State University, Central receiving 200 W. Lake St. Campus Delivery 1619, CO 80523, USA. santiago.mejia@colostate.edu <santiago.mejia@colostate.edu>
J Santiago
JS
Mejia
Fernando
F
Moreno
Carlos
C
Muskus
Iván D
ID
Vélez
Richard G
RG
Titus
D000327:Adsorption; D000818:Animals; D001698:Biomedical Engineering / Q000379:methods*; D006790:Host-Parasite Interactions / Q000502:physiology*; D006801:Humans; D017053:Infection Control / Q000379:methods*; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D014774:Virulence / Q000502:physiology
D011506:Proteins