An infantile Cushing syndrome due to misuse of topical steroid.
Chronic low-dose exogenous steroid therapy in children can result in hypothalamic-pituitary-adrenal axis dysfunction. However, the development of Cushing syndrome from topical steroid therapy is unusual. A 9-month-old girl with a diagnosis of Cushing syndrome caused by long-term topical clobetasol propionate application was evaluated. The patient was found to have severe adrenal suppression. Limiting the use of steroid-containing drugs, prescription of less potent agents, especially during infancy, and warning of parents about potential side effects are very important.
Siklar
Zeynep
Z
Department of Pediatrics, Ankara Hospital, Ankara, Turkey. zeynepsklr@hotmail.com
Bostanci
Ilknur
I
Atli
Ozlem
O
Dallar
Yildiz
Y
D000279:Administration, Cutaneous; D002990:Clobetasol / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003480:Cushing Syndrome / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D003963:Diaper Rash / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant
D005938:Glucocorticoids; D002990:Clobetasol