Serum CC-10 in inflammatory lung diseases.
BACKGROUND
Although Clara cell secretory protein (CC-10) has been ascribed an anti-inflammatory role in lung diseases, its precise role remains unclear.


OBJECTIVE
To further our understanding of the role of CC-10 in inflammatory lung diseases, CC-10 protein levels were measured.


METHODS
Sera or bronchoalveolar lavage (BAL) fluids were collected from patients with different inflammatory lung diseases including bronchial asthma, chronic obstructive lung disease (COPD), sarcoidosis, idiopathic interstitial pneumonia (IIP), chronic eosinophilic pneumonia (CEP), pneumonia and lung cancer. Serum CC-10 concentrations were measured by enzyme-linked immunosorbent assay using urinary protein-1 antibody. Then, the relationships between CC-10 concentrations and lung diseases were investigated. Immunohistochemistry was performed using lung biopsy samples.


RESULTS
Increased serum CC-10 levels were recognized in IIP patients, while CC-10 levels were decreased in bronchial asthma patients and CEP patients. Immunohistochemistry revealed an aberrant expression in areas of fibrosis in IIP patients. Serum CC-10 concentrations were not associated with severity among IIP, COPD, and sarcoidosis. In contrast, serum CC-10 concentrations were correlated with FEV(1)/FVC in bronchial asthma patients.


CONCLUSIONS
Although the number of patients was quite limited, these data provide new insights into the role of CC-10 in lung diseases, and the possibility that the CC-10 concentration in serum could be a new marker indicating the severity of bronchial asthma.
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Qing
Q
Ye
Masaki
M
Fujita
Hiroshi
H
Ouchi
Ichiro
I
Inoshima
Takashige
T
Maeyama
Kazuyoshi
K
Kuwano
Yasuhiro
Y
Horiuchi
Nobuyuki
N
Hara
Yoichi
Y
Nakanishi
D000328:Adult; D016022:Case-Control Studies; D018450:Disease Progression; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D007249:Inflammation / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000097:blood* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014018:Tissue Distribution; D014598:Uteroglobin / Q000097:blood* / Q000378:metabolism
C556389:SCGB1A1 protein, human; D014598:Uteroglobin