[The Use of Clopidogrel in Conjunction With Thrombolytic Therapy in PatientsWith ST-Elevation Acute Myocardial Infarction.].
Clopidogrel (300 mg before initiation of thrombolysis and 75 mg/day thereafter) was given to 46 of 131 patients with streptokinase treated ST-elevation acute myocardial infarction. Mortality and efficacy of thrombolysis were similar in 2 groups, however deaths of acute heart failure were distributed unevenly (0 in clopidogrel group and 8 or 9.4% among other patients, p <0.03). Clopidogrel treated compared with other patients had significantly higher left ventricular ejection fraction on days 1-2 of disease (52.5+/-2.2 and 45.9+/-2.0%, respectively, p<0.03). Number of bleedings did not differ significantly between 2 groups. Thus patients addition of clopidogrel to aspirin and thrombolysis with streptokinase was associated with better myocardial contractile function and lower mortality due to acute heart failure.
Moscow State Medical Dental University; ul. Delegatskaya 20, 103473 Moscow, Russia.
Iu A
IuA
Dyskin
O V
OV
Makarycheva
E Iu
EIu
Vasil'eva
A V
AV
Shpektor
D001241:Aspirin / Q000627:therapeutic use; D006801:Humans; D009203:Myocardial Infarction; D013300:Streptokinase / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D016277:Ventricular Function, Left
D013300:Streptokinase; D001241:Aspirin