What is the role of high-frequency ventilation in adult respiratory distress syndrome?
The goal of positive-pressure mechanical ventilation is to provide respiratory support to a patient while allowing the underlying diseased lungs to heal. Research using both animal models and humans suggests that positive-pressure ventilation can injure the lung through both overdistension and under recruitment. Theoretically,the ultimate lung-protective strategy would consist of very small tidal volumes to avoid pressure swings while maintaining alveolar recruitment. High-frequency ventilation provides such a strategy of mechanical ventilation. This article examines the utility of using high-frequency modes of mechanical ventilation in supporting the patient with ARDS.
Bartz
Raquel R
RR
Division of Pulmonary, Allergy, and Critical Care and the Department of Anesthesia, Duke University Medical Center, Box 3221, Durham, NC 27710, USA. bartz001@mc.duke.edu
D000818:Animals; D006612:High-Frequency Ventilation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D011175:Positive-Pressure Respiration / Q000009:adverse effects* / Q000379:methods; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000401:mortality / Q000517:prevention & control / Q000628:therapy*; D013990:Tidal Volume / Q000502:physiology