Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death.
UTH1 is a yeast aging gene that has been identified on the basis of stress resistance and longer life span of mutants. It was also shown to participate in mitochondrial biogenesis. The absence of Uth1p was found to trigger resistance to autophagy induced by rapamycin. Uth1p is therefore the first mitochondrial protein proven to be required for the autophagic degradation of mitochondria. Since this protein is also involved in yeast cell death induced by heterologous expression of the pro-apoptotic protein Bax, the results are discussed in the light of evidence suggesting a co-regulation of apoptosis and autophagy in mammalian cells.
Camougrand
Nadine
N
Institut de Biochimie et Genetique, Cellulaires du CNRS, UMR5095 CNRS/Université de Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France. n.camougrand@ibgc.u-bordeaux2.fr
Kissová
Ingrid
I
Velours
Gisèle
G
Manon
Stéphen
S
D000595:Amino Acid Sequence; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D001343:Autophagy / Q000235:genetics / Q000502:physiology; D018882:Heat Stress Disorders / Q000235:genetics / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins; D008928:Mitochondria / Q000235:genetics / Q000502:physiology*; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*; D051028:bcl-2-Associated X Protein
D006360:Heat-Shock Proteins; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D029701:Saccharomyces cerevisiae Proteins; C116477:UTH1 protein, S cerevisiae; D051028:bcl-2-Associated X Protein