Dental characteristics of the Wolf-Hirschhorn syndrome: a case report.
Little attention in the dental literature has been given to the dental characteristics of patients with the Wolf-Hirschhorn Syndrome (WHS). The syndrome is caused by deletions of the terminal portion of the short arm of chromosome 4. This case report provides information on dental anomalies noted in a child with WHS. The dental findings include agenesis of multiple permanent teeth, particularly premolars and molars, taurodontism, and over-retained primary teeth. This syndrome exhibits variable clinical expressivity, possibly due to the extent and the specific locus of the chromosomal deletion. Further studies are required to obtain a clearer view of the clinical oral/dental manifestations of this syndrome.
Babich
Sara B
SB
Department of Dentistry, Long Island College Hospital, Brooklyn, NY, USA. SBbabich@aol.com
Banducci
Carla
C
Teplitsky
Paul
P
D000015:Abnormalities, Multiple; D001641:Bicuspid / Q000002:abnormalities; D002648:Child; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D003786:Dental Pulp Cavity / Q000002:abnormalities; D005260:Female; D006801:Humans; D008963:Molar / Q000002:abnormalities; D014071:Tooth Abnormalities / Q000473:pathology*; D014078:Tooth Eruption / Q000235:genetics; D014094:Tooth, Deciduous / Q000002:abnormalities