Infectious non-self recognition in invertebrates: lessons from Drosophila and other insect models.
The vertebrate innate immune system recognizes infectious non-self by employing a set of germline-encoded receptors such as nucleotide-binding oligomerisation domain proteins (NODs) or Toll-like receptors (TLRs). These proteins are involved in the recognition of various microbial-derived molecules, including lipopolysaccharide (LPS), peptidoglycan (PGN) and beta1,3-glucan. Drosophila Toll receptors are not directly dedicated to non-self recognition and insect NOD orthologues have not yet been identified. Studies started more than 20 years ago and conducted on different insect models have identified other receptors on which invertebrate innate systems rely to sense invading microorganisms.
Royet
Julien
J
UPR 9022 CNRS réponse immunitaire des invertébrés, Institut de Biologie Moléculaire et Cellulaire, Université Louis Pasteur, 15 rue René Descartes, 67084 Strasbourg, France. j.royet@ibmc.u-strasbg.fr
D000209:Acute-Phase Proteins / Q000276:immunology / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000276:immunology / Q000378:metabolism; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism*; D004330:Drosophila / Q000276:immunology* / Q000382:microbiology; D029721:Drosophila Proteins / Q000276:immunology / Q000502:physiology; D005786:Gene Expression Regulation / Q000276:immunology / Q000502:physiology; D007113:Immunity, Innate / Q000276:immunology*; D019476:Insect Proteins / Q000276:immunology / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000276:immunology / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology; D051193:Toll-Like Receptors
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D002352:Carrier Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D011956:Receptors, Cell Surface; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; C118897:peptidoglycan recognition protein