PtCl2-Catalyzed transannular cycloisomerization of 1,5-enynes: a new efficient regio- and stereocontrolled access to tricyclic derivatives.
[reaction: see text] Transannular PtCl(2)-catalyzed cycloisomerizations open a new route to cyclopropanic tricyclic systems. Ketones A or C were efficiently prepared from the same cycloundec-5-en-1-yne precursor B, depending on the substituent at the propargylic position (either benzoate or methoxy).
Laboratoire de Chimie Organique, UMR CNRS 7611, Université Pierre et Marie Curie, Case 229, 4 place Jussieu, 75252 Paris Cedex 05, France.
Christophe
C
Blaszykowski
Youssef
Y
Harrak
Maria-Helena
MH
Gonçalves
Jean-Manuel
JM
Cloarec
Anne-Lise
AL
Dhimane
Louis
L
Fensterbank
Max
M
Malacria