[Association of interleukin-1 gene polymorphism with gastric cancer in a high-risk area of China].
OBJECTIVE
To study the difference in the frequencies of interleukin-1B (IL-1) +3954, -511, -31 and IL-1RN gene polymorphism between gastric cancer patients and normal subjects in Shaanxi Province, a high risk area of gastric cancer of China.


METHODS
The genomic DNA was extracted from the peripheral blood of 169 normal subjects and 86 gastric cancer patients in Shaanxi Province. IL-1 polymorphisms were analyzed using PCR-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
T/T genotype frequencies of IL-1 in +3954, -511, -31 and IL-1RN loci were similar between gastric cancer patients and normal subjects (x(2) = 0, 0.04, 0.3 and 0, P>0.05, respectively).


CONCLUSIONS
IL-1 gene polymorphism may be not associated with the risk of gastric cancer in this high-risk area.
Hu
Sheng
S
Oncology Hospital of Hubei Province, Wuhan 430079, China. ehusmn@yahoo.com.cn
Song
Qi-bin
QB
Yu
Ding
D
Ke
Yu-hua
YH
Hu
Pin-jing
PJ
Zeng
Zhi-rong
ZR
D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012494:Sampling Studies; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics*
D007375:Interleukin-1