[Strain-specific antibodies as an indicator of the circulation of wild poliomyelitis viruses and their role in the formation of collective immunity in the population].
Essential differences in the intensity of collective immunity to poliomyelitis in the donors of Moscow and Kaluga were established. To find out the nature of high characteristics of collective immunity to poliovirus, types 1 and 2, in the donors of Kaluga, strain-specific antibodies to wild and vaccine polioviruses were studied. In a considerable number of donors strain-specific antibodies to poliovirus, types 1 and 2, were detected. This made it possible to presume a sufficiently wide circulation of these viruses among the population of the city in the middle of the 20th century and, as a consequence, high level of collective immunity appeared. Strain-specific antibodies to poliovirus of type 3 were rarely detected. This made it possible to suggest that the circulation of viruses of this type among the population was limited. Immunity to viruses of this type was due only to immunization. For this reason the characteristics of collective immunity in the donors of Moscow and Kaluga coincided. The detection of strain-specific antibodies to poliomyelitis virus allowed to retrospectively form the opinion of the spread and time of the circulation of wild poliomyelitis viruses in the population.
V B
VB
Seĭbil'
L P
LP
Malyshkina
I K
IK
Lavrova
V F
VF
Efimova
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008875:Middle Aged; D011051:Poliomyelitis / Q000097:blood* / Q000453:epidemiology; D017955:Poliovirus / Q000276:immunology / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral / Q000276:immunology; D012426:Russia / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D014505:Urban Population
D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral