Adherin: key to the cohesin ring and cornelia de Lange syndrome.
Adherin facilitates sister chromatid cohesion, DNA repair and binding of the cohesin complex to chromosomes. New studies indicate that adherin activity is coordinated with DNA replication and chromosome segregation, and that its dosage is critical for gene expression and human development.
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA.
Dale
D
Dorsett
D006801:Humans; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D002842:Chromatids / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology; D002875:Chromosomes / Q000378:metabolism; D003635:De Lange Syndrome / Q000235:genetics; D004261:DNA Replication / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D008954:Models, Biological
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins