Antimicrobial and cytotoxic agents from Calophyllum inophyllum.
The study of the chemical constituents of the root bark and the nut of Calophyllum inophyllum has resulted in the isolation and characterization of a xanthone derivative, named inoxanthone, 3, together with 12 known compounds: caloxanthones A, 4 and B, 5, macluraxanthone, 6, 1,5-dihydroxyxanthone, 7, calophynic acid, 8, brasiliensic acid, 9 inophylloidic acid, 10, friedelan-3-one, 11, calaustralin, 12, calophyllolide, 13, inophyllums C, 14 and E, 15. Their structures were established on the basis of spectral evidence. Their in vitro cytotoxicity against the KB cell line and their antibacterial activity and potency against a wide range of micro organisms were evaluated.
Department of Organic Chemistry, Faculty of Science, University of Yaounde I, PO Box 812, Yaounde, Cameroon.
Marie C
MC
Yimdjo
Anatole G
AG
Azebaze
Augustin E
AE
Nkengfack
A Michele
AM
Meyer
Bernard
B
Bodo
Zacharias T
ZT
Fomum
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D001419:Bacteria / Q000187:drug effects; D029759:Calophyllum / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D044004:Xanthones