Orthopaedic concerns in children with growth hormone therapy.
Growth hormone (GH) therapy is widely used in children; it may have various severe orthopaedic complications. Slipped capital femoral epiphysis, Legg-Calvé-Perthes disease, scoliosis and carpal tunnel syndrome may occur with GH treatment. Before beginning GH therapy, it is important to take into account all the risk factors of the individual patient, as some conditions could contraindicate GH treatment. During GH treatment, close monitoring with both clinical and radiographic examination is mandatory. The paediatric orthopaedic surgeon will frequently be asked about the management of these complications and about the necessity for treatment arrest. The authors review the orthopaedic complications which the orthopaedic surgeon may encounter in patients treated with GH.
Docquier
Pierre-Louis
PL
Department of Orthopaedic Surgery, University Clinics Saint-Luc, Brussels, Belgium. Pierre-Louis.Docquier@clin.ucl.ac.be
Mousny
Maryline
M
Jouret
Mathieu
M
Bastin
Christophe
C
Rombouts
Jean-Jacques
JJ
D000293:Adolescent; D002349:Carpal Tunnel Syndrome / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004839:Epiphyses, Slipped / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000175:diagnosis / Q000188:drug therapy*; D013006:Growth Hormone / Q000172:deficiency; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007873:Legg-Calve-Perthes Disease / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D009140:Musculoskeletal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D011859:Radiography; D018570:Risk Assessment; D012600:Scoliosis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery; D012720:Severity of Illness Index; D016896:Treatment Outcome
D019382:Human Growth Hormone; D013006:Growth Hormone