Metabolic storage diseases: amyloidosis.
This article provides an overview of the current concepts in pathogenesis, epidemiology, clinical significance, and treatment options for amyloidosis. Emphasis is given to hepatic amyloidosis, which ranges from a clinically insignificant histologic curiosity to a harbinger of widespread disease accompanied by a poor prognosis. Clinical characteristics and clues to the diagnosis are discussed as well as the importance of histologic confirmation and the controversy surrounding liver biopsy.
Brunt
Elizabeth M
EM
Department of Pathology, Saint Louis University School of Medicine, 4(th) Floor, SLUH, 3635 Vista Avenue, St. Louis, MO 63110, USA. bruntem@slu.edu
Tiniakos
Dina G
DG
D000686:Amyloidosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D015994:Incidence; D008099:Liver / Q000473:pathology*; D011379:Prognosis