Adult onset Fanconi syndrome: extensive tubulo-interstitial lesions and glomerulopathy in the early stage of Chinese herbs nephropathy.
A 33-year-old woman was transferred to our hospital with a 5-month history of taking Chinese herbal medicine containing aristolochic acid. She presented with metabolic acidosis, severe anemia, hypophosphatemia and uric aciduria, and generalized aminoaciduria and glycosuria, features which were consistent with the clinical manifestations of Fanconi syndrome. Renal biopsy was performed when her plasma creatinine was 0.7 mg/dl and creatinine clearance was 46 ml/min per 1.73 m(2). The renal specimen showed extensive interstitial edema with focal fibrosis, tubular atrophy, and focal glomerulopathy, which suggested the presence of glomerular endothelial damage or glomerular ischemia. Although steroid therapy ameliorated the plasma electrolyte levels, renal failure progressed, and hemodialysis therapy was initiated approximately 18 months after the time of renal biopsy. This patient demonstrated the early renal lesions of Chinese herbs nephropathy in association with various clinical manifestations. The characteristic glomerulopathy found in the present patient is considered to be an additional renal lesion, leading to the renal failure.
Kazama
Itsuro
I
Division of Molecular Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.
Matsubara
Mitsunobu
M
Michimata
Mari
M
Suzuki
Michiko
M
Hatano
Ryo
R
Sato
Hiroshi
H
Ito
Sadayoshi
S
D000328:Adult; D034341:Aristolochic Acids / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005198:Fanconi Syndrome / Q000473:pathology*; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology*; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology*
D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; C000228:aristolochic acid I