Bioadhesion and biocompatibility evaluations of gelatin and polyacrylic acid as a crosslinked hydrogel in vitro.
This study describes the potentiality of crosslinked hydrogels comprised of gelatin and polyacrylic acid (CHGP) as a biological glue for soft tissues and compares its bonding strength with that of fibrin glue. Water-soluble carbodimide (WSC) was used to crosslink the mixture of gelatin and polyacrylic acid (PAA). An addition of PAA to gelatin increases bonding strength and reduces the gelation time and WSC concentration. Increasing the gelatin, WSC and PAA concentration increases the bonding strength. There is a critical concentration to have a maximum bonding strength. The cured hydrogel exhibited sufficient adhesion to mouse skin with a higher bonding strength than fibrin glue. The in vitro test has been done for evaluating CHGP toxicity.
Amirkabir University of Technology, Department of Polymer Engineering, Hafez Avenue, Tehran, Iran.
Rosa
R
Ghavamzadeh
Vahid
V
Haddadi-Asl
Hamid
H
Mirzadeh
D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry* / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D051379:Mice; D012867:Skin / Q000737:chemistry / Q000187:drug effects; D013997:Time Factors; D000267:Tissue Adhesions; D014867:Water / Q000032:analysis / Q000737:chemistry
D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D020100:Hydrogels; D014867:Water; C006903:carbopol 940; D005780:Gelatin