High throughput approaches in neuroscience.
Traditional approaches to understanding biological problems are now being advanced with the use of high throughput technologies, which analyse multiple samples simultaneously, or thousands of analytes in a single sample. The application of these technologies in neurochemistry and neuroscience is beginning to be explored and is assisting in the development of new models of drug action, neuroanatomical investigations, and in identifying molecular pathways involved in neurological and psychiatric disease. Tools such as microarray-based gene expression profiling and 2D and multidimensional proteomic methods are uncovering functional components to a wide variety of neuroscience paradigms and the application of these technologies is set to become standard in analysis.
Morris
C M
CM
MRC Building, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne, Tyne and Wear, NE4 6BE, UK. c.m.morris@ncl.ac.uk
Wilson
K E
KE
D000818:Animals; D020869:Gene Expression Profiling / Q000379:methods* / Q000639:trends; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods / Q000639:trends; D008967:Molecular Biology / Q000379:methods* / Q000639:trends; D009448:Neurochemistry / Q000379:methods* / Q000639:trends; D009488:Neurosciences / Q000379:methods* / Q000639:trends; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods / Q000639:trends; D025941:Protein Interaction Mapping / Q000379:methods / Q000639:trends; D040901:Proteomics / Q000379:methods / Q000639:trends