[The influence of panthotenic acid mitochondrial oxidation and oxidative phosphorylation in liver of rats with alimentary obesity].
Alimentary obesity induced by the long-term feeding of rats by high-fat diet results the reducing of rate and efficiency of oxidative phosphorylation in liver mitochondria when NAD-dependent substrates are used. The treatment of the obese rats with panthotenic acid derivatives (phosphopantotenate, panthetin, panthenol) enhanced oxidative phosphorylation of pyruvate and fatty acid carnitine esters. Among investigated compounds panthenol activated respiratory control and phosphorylation rate more effectively. Moreover, panthenol, but not phosphopanthotenate nor panthetine, increased the activity of carnitine palmitoyltransferase 1 that confirms the preferable usage of fatty acids for mitochondrial oxidation under the influence of this compound.
Naruta
E E
EE
Egorov
A I
AI
Omel'ianchik
C N
CN
Buko
V U
VU
D000818:Animals; D002331:Carnitine / Q000378:metabolism; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D008930:Mitochondria, Liver / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010205:Pantothenic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats
D005227:Fatty Acids; D010205:Pantothenic Acid; D019289:Pyruvic Acid; D002334:Carnitine O-Palmitoyltransferase; D002331:Carnitine