Breast cancer: the role of angiogenesis and antiangiogenic therapy.
Angiogenesis plays a role in breast cancer development. Preclinical and clinical evidence is reviewed. Development of targeted antiangiogenic agents provides new challenges to clinical trial design. Current antiangiogenic therapy with traditional agents and novel agents are classified and reviewed.
Miller
Kathy D
KD
Division of Hematology and Medical Oncology, Indiana University, 535 Barnhill Drive, RT-473, Indianapolis, IN 46202, USA. kathmill@iupui.edu
Dul
Carrie L
CL
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000453:epidemiology / Q000401:mortality; D005260:Female; D006801:Humans; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D011480:Protease Inhibitors / Q000627:therapeutic use; D014481:United States / Q000453:epidemiology
D020533:Angiogenesis Inhibitors; D011480:Protease Inhibitors