Synthesis and anti-tuberculosis activity of N-aryl-C-nitroazoles.
Twelve N-aryl derivatives of 4-nitroimidazole, 2-methyl-4-nitroimidazole, 4-nitropyrazole or 3-nitro-1,2,4-triazole have been synthesized either by a degenerated ring transformation reaction of 1,4-dinitroimidazoles with 4-substituted anilines or by a condensation of fluoronitrobenzenes with salts prepared from C-nitro-1H-azoles and 1,8-diazabicyclo[5.4.0]-7-undecene. The Tuberculosis Antimicrobial Acquisition and Coordinating Facility has provided anti-mycobacterial data concerning inhibition activity of 12 compounds.
Walczak
Krzysztof
K
Department of Organic Chemistry, Biochemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland.
Gondela
Andrzej
A
Suwiński
Jerzy
J
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000502:physiology; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000995:Antitubercular Agents; D001393:Azoles; D009593:Nitroimidazoles