The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings.
Several studies have demonstrated the involvement of 5-HT1A receptors in the pathogenesis of depression and in the antidepressant response to SSRIs. A functional new variant in the promoter region of the 5-HT1A gene was recently reported (-1019 C>G). The aim of this study is to investigate a possible association between this 5-HT1A receptor variant and antidepressant response to fluvoxamine in a sample of 262 mood-disorder subjects (151 major depressed and 111 bipolars) treated with fluvoxamine for 6 wk. The severity of depressive symptoms was assessed weekly with the Hamilton Rating Scale for Depression (HAMD). 5-HT1A variants did not influence antidepressant response in the whole sample and in unipolar subjects. In bipolars, 5-HT1A*C/C genotype carriers showed a better response to fluvoxamine (p=0.036), independently from clinical variables. The 5-HT1A polymorphism effect on antidepressant response was independent from the previously reported effect of the 5-HTTLPR polymorphism. In conclusion, 5-HT1A variants could influence the antidepressant efficacy in bipolar subjects, even if results must be verified on larger samples.
Department of Psychiatry, School of Medicine, Vita-Salute University San Raffaele, Milan, Italy. serretti.alessandro@hsr.it
Alessandro
A
Serretti
Paola
P
Artioli
Cristina
C
Lorenzi
Adele
A
Pirovano
Viviana
V
Tubazio
Raffaella
R
Zanardi
D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D004247:DNA / Q000235:genetics; D005260:Female; D016666:Fluvoxamine / Q000627:therapeutic use; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*
D018687:Antidepressive Agents, Second-Generation; D044282:Receptor, Serotonin, 5-HT1A; D004247:DNA; D016666:Fluvoxamine