Evidence for archaic Asian ancestry on the human X chromosome.
The human RRM2P4 pseudogene has a pattern of nucleotide polymorphism that is unlike any locus published to date. A gene tree constructed from a 2.4-kb fragment of the RRM2P4 locus sequenced in a sample of 41 worldwide humans clearly roots in East Asia and has a most-recent common ancestor approximately 2 Myr before present. The presence of this basal lineage exclusively in Asia results in higher nucleotide diversity among non-Africans than among Africans. A global survey of a single-nucleotide polymorphism that is diagnostic for the basal, Asian lineage in 570 individuals shows that it occurs at frequencies up to 53% in south China, whereas only one of 177 surveyed Africans carries this archaic lineage. We suggest that this ancient lineage is a remnant of introgressive hybridization between expanding anatomically modern humans emerging from Africa and archaic populations in Eurasia.
Garrigan
Daniel
D
Mobasher
Zahra
Z
Severson
Tesa
T
Wilder
Jason A
JA
Hammer
Michael F
MF
D000349:Africa; D000818:Animals; D001208:Asia; D044466:Asian People / Q000235:genetics*; D002681:China; D041321:Chromosomes, Human, X / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D011110:Polymorphism, Genetic; D011544:Pseudogenes / Q000235:genetics*; D012262:Ribonucleoside Diphosphate Reductase / Q000235:genetics*
C093713:ribonucleotide reductase M2; D012262:Ribonucleoside Diphosphate Reductase