Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds.
A family of compounds based upon the chemical structure of valproate were synthesized and assayed for their ability to inhibit glycogen synthase kinase (GSK)-3 alpha and beta activity in vitro. This data is correlated to the known anti-convulsant properties of these compounds in order to determine the potential role of GSK-3 inhibition in the therapeutic efficacy of these drugs.
Department of Biochemistry and Biomedical Sciences, Henderson Research Centre, 711 Concession Street, Hamilton, Ontario, Canada L8V 1C3. gwerstuck@thrombosis.hhscr.org
Geoff H
GH
Werstuck
Anna J
AJ
Kim
Timothy
T
Brenstrum
Stephan A
SA
Ohnmacht
Ella
E
Panna
Alfredo
A
Capretta
D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D014635:Valproic Acid / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*
D000927:Anticonvulsants; D004791:Enzyme Inhibitors; D014635:Valproic Acid; D038362:Glycogen Synthase Kinase 3