The history of intratympanic drug therapy in otology.
The application of drugs through the eardrum and into the middle ear to treat various otologic disorders has recently gained wide-spread popularity. Despite the relatively recent interest in this technique, if one considers any application of medication into the middle ear as intratympanic therapy, the roots of this method can really be considered to date back to antiquity. This article presents the development of intratympanic drug therapy from early times through the nineteenth century.
Lustig
Lawrence R
LR
Department of Otolaryngology-Head & Neck Surgery, University of California San Francisco, 400 Parnassus Avenue, Suite ACC-746, San Francisco, CA 94143-0342, USA. llustig@ohns.ucsf.edu
D000287:Administration, Topical; D004427:Ear Diseases / Q000188:drug therapy / Q000266:history*; D049668:History, 15th Century; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D014432:Tympanic Membrane