Isolated cranial neuropathy associated with anti-glycolipid antibodies.
We describe seven patients with isolated cranial neuropathy in whom serum anti-glycolipid antibodies were detected. Trigeminal sensory neuropathy was found in four patients, who had exhibited symptoms for 2 months to 4 years. The other three patients showed facial nerve palsy with or without ophthalmoparesis. Temporal profile analysis of anti-glycolipid antibodies revealed that titers of anti-glycolipid IgM antibodies against GM2 and LM1 gradually decreased in patients having chronic trigeminal sensory neuropathy. In patients with acute trigeminal sensory neuropathy, elevation of anti-LM1 antibody titers continued over 12 months although anti-GalNAc-GD1a antibody disappeared. On the other hand, titers of anti-glycolipid antibodies rapidly decreased in patients with acute facial nerve palsy with or without ophthalmoparesis. We conclude that anti-glycolipid antibodies may play an important role in the development of isolated cranial neuropathy in some patients.
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Makoto
M
Kunishige
Takao
T
Mitsui
Hiide
H
Yoshino
Atsuko
A
Asano
Miho
M
Tsuruo
Itsuro
I
Endo
Fumikazu
F
Yagi
Toshio
T
Matsumoto
D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D001767:Blinking / Q000502:physiology; D003389:Cranial Nerve Diseases / Q000145:classification / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D003587:Cytomegalovirus / Q000276:immunology; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D005678:G(M2) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D006017:Glycolipids / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D005732:Gangliosides; D006017:Glycolipids; C036208:LM1 ganglioside; C044203:anti-IgM; D005678:G(M2) Ganglioside; C055253:IV(4)-galactosyl-N-acetylganglioside GD1a