Social support as a buffer in the relationship between treatment for depression and T-cell production of interferon gamma in patients with multiple sclerosis.
OBJECTIVE
This study examined the buffering effects of social support on the relationship between depression and autoaggressive immune function in multiple sclerosis (MS).


METHODS
Fourteen participants with comorbid diagnoses of MS and major depressive disorder received 16 weeks of psychotherapy or antidepressant medications. Depression and T-cell production of interferon-gamma (IFN-gamma), a lynchpin in MS pathogenesis, were assessed at baseline and posttreatment. Social support was assessed at baseline.


RESULTS
Both depression and T-cell production of IFN-gamma were significantly reduced over the 16 weeks of treatment. There was a significant interaction between change in depression, change in IFN-gamma, and social support (R(2)=.26, P=.03) such that social support served as a buffer.


CONCLUSIONS
These results support the hypothesis that social support buffers the effects of change in depression on IFN-gamma production. However, these findings should be viewed as preliminary due to the small sample size and the absence of a control condition.
Mohr
David C
DC
Departments of Psychiatry and Neurology, and VA Medical Center, University of California-San Francisco, 4150 Clement Street (116-A), San Francisco, CA 94121, USA. dmohr@itsa.ucsf.edu
Genain
Claude
C
D000328:Adult; D000368:Aged; D003863:Depression / Q000097:blood* / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000523:psychology; D011584:Psychology; D012944:Social Support; D011795:Surveys and Questionnaires; D013601:T-Lymphocytes / Q000378:metabolism*
D007371:Interferon-gamma