A normal organ antigen and its corresponding antibodies in pathological human sera.
Previous studies on the appearance in pathological human sera of antibodies to an antigen of normal mammalian organs were continued. In gel precipitation reactions, antibodies combining with saline extracts of mammalian organs were found in 20 of 63 cancer sera and in 4 of 15 syphilis sera, but only in 3 of 56 other pathological sera. Furthermore, an identical antigen was demonstrated in 5 of 58 pathological sera. The antigen under study did not belong to any group of known heterophile antigens and it was devoid of organ and tissue specificity.
Milgrom
Felix
F
Department of Microbiology and Immunology, State University of New York at Buffalo, NY 14214, USA. milgrom@buffalo.edu
Czechowski
Donna
D
D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000097:blood / Q000276:immunology*; D002417:Cattle; D003110:Colonic Neoplasms / Q000097:blood / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D008099:Liver / Q000276:immunology; D013587:Syphilis / Q000097:blood / Q000276:immunology*; D013588:Syphilis Serodiagnosis; D014020:Tissue Extracts / Q000276:immunology
D000910:Antibodies, Heterophile; D000941:Antigens; D000951:Antigens, Neoplasm; D014020:Tissue Extracts