Model for transition from waves to synchrony in the olfactory lobe of Limax.
A biophysical model for the interactions between bursting (B) cells and nonbursting (NB) cells in the procerebral lobe of Limax is developed and tested. Phase-sensitivity of the NB cells is exhibited due to the strong inhibition from the rhythmically bursting B cells. Electrical and chemical junctions coupled with a parameter gradient lead to sustained periodic waves in the lobe. Excitatory interactions between the NB cells, which rarely fire, lead to stimulus evoked synchrony in the lobe oscillations. A novel calcium current is suggested to explain the effects of nitric oxide (NO) on the lobe. Gap junctions are shown both experimentally and through simulations to be required for the oscillating field potentials.
Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Bard
B
Ermentrout
Jing W
JW
Wang
Jorge
J
Flores
Alan
A
Gelperin
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001562:Benzimidazoles / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004347:Drug Interactions; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology / Q000528:radiation effects; D018756:GABA Antagonists / Q000494:pharmacology; D017952:Ganglia, Invertebrate / Q000166:cytology; D017629:Gap Junctions / Q000502:physiology / Q000528:radiation effects; D006034:Glycyrrhetinic Acid / Q000494:pharmacology; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008959:Models, Neurological; D008974:Mollusca; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000145:classification / Q000502:physiology*; D009812:Odorants; D009830:Olfactory Bulb / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D018408:Patch-Clamp Techniques / Q000379:methods; D010507:Periodicity; D010852:Picrotoxin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors
D001562:Benzimidazoles; D002712:Chlorides; D018756:GABA Antagonists; D006034:Glycyrrhetinic Acid; D010852:Picrotoxin; C447680:hoechst 32258