Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.
Most cortical interneurons arise from the subcortical telencephalon, but the molecules that control their migration remain largely unidentified. Here, we show that different isoforms of Neuregulin-1 are expressed in the developing cortex and in the route that migrating interneurons follow toward the cortex, whereas a population of the migrating interneurons express ErbB4, a receptor for Neuregulin-1. The different isoforms of Neuregulin-1 act as short- and long-range attractants for migrating interneurons, and perturbing ErbB4 function in vitro decreases the number of interneurons that tangentially migrate to the cortex. In vivo, loss of Neuregulin-1/ErbB4 signaling causes an alteration in the tangential migration of cortical interneurons and a reduction in the number of GABAergic interneurons in the postnatal cortex. These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system.
Flames
Nuria
N
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 San Joan d'Alacant, Spain.
Long
Jason E
JE
Garratt
Alistair N
AN
Fischer
Tobias M
TM
Gassmann
Martin
M
Birchmeier
Carmen
C
Lai
Cary
C
Rubenstein
John L R
JL
Marín
Oscar
O
D000818:Animals; D019556:COS Cells; D002465:Cell Movement / Q000502:physiology*; D002540:Cerebral Cortex / Q000196:embryology*; D002522:Chlorocebus aethiops; D066246:ErbB Receptors / Q000378:metabolism; D017403:In Situ Hybridization; D007395:Interneurons / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D020890:Neuregulin-1 / Q000502:physiology*; D020033:Protein Isoforms / Q000502:physiology; D066247:Receptor, ErbB-4; D015398:Signal Transduction
D020890:Neuregulin-1; D020033:Protein Isoforms; D066246:ErbB Receptors; C587690:Erbb4 protein, mouse; D066247:Receptor, ErbB-4