Amphotericin B as a potential probe of the physical state of vesicle membranes.
[structure: see text] The investigations described introduce a new role for a natural product such as amphotericin B as a potential biophysical reporter group to probe the physical state of a membrane. Specifically, we demonstrated that the K(+) efflux pattern reveals an interesting sterol dependence. This is suggested to be correlated to the physical state of the membrane showing high efflux in a vesicle membrane of intermediate fluidity.
Zumbuehl
Andreas
A
Laboratorium für Organische Chemie, ETH Hönggerberg CH-8093 Zürich, Switzerland.
Stano
Pasquale
P
Heer
Dominik
D
Walde
Peter
P
Carreira
Erick M
EM