Transfer of celecoxib into human milk.
The aim of this study was to investigate the transfer of celecoxib into human milk. In one group of 3 breastfeeding patients on celecoxib at steady state, milk levels were determined at set intervals over 24 hours. Plasma levels were determined in 2 of their infants, age 17 and 22 months. In a second group of 2 subjects, intravenous lines were placed and a single 200-mg dose of celecoxib was followed by multiple paired plasma and milk samples over 8 hours. The mean milk-to-plasma ratio for celecoxib was 0.23 (95% confidence interval [CI]: 0.15-0.31). The average concentration of celecoxib in milk during the 8-hour dosing interval was 66 microg/L (95% CI: 41-89). The absolute infant dose averaged 9.8 microg/kg/d (95% CI: 6.2-13.4); the mean relative infant dose was 0.30%. Therefore, the average clinical dose transferred to the infant daily would be approximately 0.3% of the weight-adjusted maternal dose. The authors suggest that the use of celecoxib in breastfeeding mothers at these doses is very unlikely to cause untoward effects in breastfed infants.
Hale
Thomas W
TW
Department of Pediatrics, Texas Tech University School of Medicine, Amarillo, TX, USA.
McDonald
Rose
R
Boger
James
J
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001942:Breast Feeding; D000068579:Celecoxib; D005260:Female; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007774:Lactation / Q000378:metabolism*; D008895:Milk, Human / Q000737:chemistry* / Q000378:metabolism; D011720:Pyrazoles / Q000097:blood / Q000493:pharmacokinetics*; D013449:Sulfonamides / Q000097:blood / Q000493:pharmacokinetics*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib