The effect of testosterone propionate supplement on testicular toxicity with thiamphenicol in male Sprague-Dawley rats.
Testosterone propionate (TP) was supplemented to male rats for assessment of its ameliorating effect on testicular toxicity with thiamphenicol (TAP). A total of 20 male Sprague-Dawley rats were treated orally with TAP at 200 mg/kg/day for up to 4 weeks. In addition, 5 male rats were allotted to the control group receiving vehicle only. Ten of the 20 treated rats had a Silastic capsule (containing about 80 mg of TP) implanted in the dorsal skin at Week 2 and assigned to the TAP-TP group, while the other 10 treated rats were in the TAP group. After Weeks 3 and 4, five of both treated groups were examined for weight and histology of the testis and accessory genital glands, and for staging analysis of the seminiferous tubules. The same parameters were also assessed in the control group after Week 4. Weights and morphology of the seminal vesicle and prostate recovered remarkably from the TAP toxicity after TP supplement. However, no ameliorating effects of TP were obtained for the testis in either weight, morphology, or staging analysis of the seminiferous tubules.
The Institute of Environmental Toxicology, 4321 Uchimoriya-machi, Mitsukaido, Ibaraki 303-0043, Japan.
Keizo
K
Maita
Maki
M
Kuwahara
Tadashi
T
Kosaka
Kosei
K
Inui
Kayoko
K
Sugimoto
Yukiko
Y
Kashimoto
Naofumi
N
Takahashi
Takanori
T
Harada
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D043343:Testosterone Propionate / Q000008:administration & dosage / Q000494:pharmacology*; D013839:Thiamphenicol / Q000008:administration & dosage / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D013839:Thiamphenicol; D043343:Testosterone Propionate