Pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection with profound teratospermia.
OBJECTIVE
To assess the pregnancy outcome of IVF with intracytoplasmic sperm injection (ICSI) in couples with profound teratospermia (Kruger's strict criteria of zero).


METHODS
Retrospective analysis of 545 consecutive cycles of IVF/ICSI performed between January 2000 and January 2003.


METHODS
Tertiary care center.


METHODS
Of 545 IVF/ICSI cycles, 45 patients were identified with a semen strict morphology of 0 using Kruger's strict criteria.


METHODS
Ovarian down-regulation (Lupron) was followed by controlled ovarian stimulation exclusively with hMG. Embryo transfer was performed 2 days after transvaginal aspiration/ICSI.


METHODS
Pregnancy outcomes and newborn/infant status.


RESULTS
Of 45 patients undergoing 54 treatment cycles, 21 patients were positive for pregnancy (38.9% pregnancy/cycle). No birth defects were noted at time of delivery and all infants had obtained appropriate developmental milestones at 1 year of age.


CONCLUSIONS
Men with profound teratospermia (Kruger's strict criteria of zero) may achieve acceptable pregnancy rates after IVF/ICSI thereby alleviating the use of donor sperm in this group. Furthermore, no increased risk of birth defects is apparent in this small series.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Baylor College of Medicine, Houston, Texas 77030, USA.
Laurie Jane
LJ
McKenzie
Ertug
E
Kovanci
Paula
P
Amato
Pauline
P
Cisneros
Dolores
D
Lamb
Sandra A
SA
Carson
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013081:Sperm Motility / Q000502:physiology; D013094:Spermatozoa / Q000473:pathology