Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line.
OBJECTIVE
To determine whether 2-(3-carboxy-1-oxopropy1) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109.


METHODS
Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazolium-based colorimetric assay (MTT assay).


RESULTS
COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximum inhibition rate was 83.75%.


CONCLUSIONS
COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy.
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Gansu Province, China. wujing36@163.com
Jing
J
Wu
Hong
H
Lu
Yun
Y
Zhou
Liang
L
Qiao
Rui
R
Ji
Ai-Qing
AQ
Wang
Wei-Min
WM
Liu
Qun-Ji
QJ
Xue
D000970:Antineoplastic Agents / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004938:Esophageal Neoplasms; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans
C495189:2-(3-carboxy-1-oxopropyl)amino-2-deoxy-D-glucose; D000970:Antineoplastic Agents; D003847:Deoxyglucose; D005947:Glucose