Effect of different doses of chromium picolinate on protein metabolism in infant rats.
This 12-day study was conducted to evaluate the effects of three different levels of dietary chromium (100, 200, and 500 microg/day) in the form of chromium picolinate (CrPic) on growth and protein use in weaned rats. No significant effect of CrPic on body weight gain, food intake, or food conversion rate was observed. Elevated doses of CrPic seemed to increase muscle mass, either by stimulating protein anabolism by activation of insulin by chromium or by lowering protein degradation. However, these effects had no repercussions on overall growth, suggesting that any anabolic effect of chromium due to the action of insulin was probably marginal.
Department of Nutrition, Bromatology and Toxicology, Faculty of Pharmacy, University of Alcalá de Henares, Madrid, Spain.
Aonio
A
Bernao
Isabel
I
Meseguer
María Victorina
MV
Aguilar
María Carmen Martínez
MC
Para
María José González
MJ
Muñoz
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects*; D043402:Cathepsin A / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism*; D019587:Dietary Supplements; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000033:anatomy & histology / Q000737:chemistry; D009584:Nitrogen / Q000378:metabolism; D009929:Organ Size; D010848:Picolinic Acids / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D004044:Dietary Proteins; D007328:Insulin; D010848:Picolinic Acids; D043402:Cathepsin A; D009584:Nitrogen; C030614:picolinic acid