Epstein-Barr virus: exploiting the immune system by interfering with defective ribosomal products.
The interaction of cytotoxic T lymphocytes with major histocompatibility complex (MHC)-peptide complexes is a critical step toward the initiation and propagation of specific immune responses against viral infection. Here we review new evidence, taking Epstein-Barr virus as an example, showing that defective ribosomal products provide an important supply of endogenous peptides for entry into the MHC class I antigen-presentation pathway.
Institut de Pharmacologie, EPI0334 Hôpital St Louis, 27, rue Juliette-Dodu 75010, France. benedicte.manoury@curie.fr
Sébastien
S
Apcher
Robin
R
Fahraeus
Bénédicte
B
Manoury
D000818:Animals; D017951:Antigen Presentation; D019309:Epstein-Barr Virus Nuclear Antigens / Q000378:metabolism*; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000472:pathogenicity*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D010455:Peptides / Q000276:immunology / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D019309:Epstein-Barr Virus Nuclear Antigens; D015395:Histocompatibility Antigens Class I; D010455:Peptides; D046988:Proteasome Endopeptidase Complex; C417029:EBV-encoded nuclear antigen 1