Quinolone resistance is associated with increased risk of invasive illness or death during infection with Salmonella serotype Typhimurium.
In a registry-based cohort study, we determined the risk of invasive illness or death associated with infection with quinolone-resistant Salmonella serotype Typhimurium. We linked data from the Danish surveillance registry of enteric pathogens with data from the Danish civil registration system and 2 national health registries. Of 1323 patients infected with Salmonella Typhimurium, 46 (3.5%) were hospitalized due an invasive illness within 90 days of infection, and 16 (1.2%) died within 90 days of infection. After adjustment for age, sex, and comorbidity, infection with quinolone-resistant Salmonella Typhimurium was associated with a 3.15-fold (95% confidence interval, 1.39-7.10-fold) higher risk of invasive illness or death within 90 days of infection, compared with that observed for infection with pansusceptible strains.
Department of Epidemiology Research, Danish Epidemiology Science Center, Copenhagen, Denmark.
Morten
M
Helms
Jacob
J
Simonsen
Kare
K
Molbak
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015331:Cohort Studies; D003718:Denmark; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D015363:Quinolones / Q000494:pharmacology*; D018570:Risk Assessment; D012480:Salmonella Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence
D000900:Anti-Bacterial Agents; D015363:Quinolones