Direct generation of Ti-enolate of alpha-CF3 ketone: theoretical study and high-yielding and diastereoselective Aldol reaction.
Success in the direct generation of the Ti-enolate of alpha-CF3 ketone and its aldol reaction is reported. The importance of Ti-F interaction during the course of the reaction is also reported.
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.
Yoshimitsu
Y
Itoh
Masahiro
M
Yamanaka
Koichi
K
Mikami
D000447:Aldehydes / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007659:Ketones / Q000138:chemical synthesis*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry; D013237:Stereoisomerism; D013816:Thermodynamics; D014025:Titanium / Q000737:chemistry
D000447:Aldehydes; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D009942:Organometallic Compounds; D014025:Titanium