Severe ciprofloxacin-associated pseudomembranous colitis in an eight-year-old child.
Clostridium difficile is the principal cause of antibiotic-associated diarrhea and pseudomembranous enterocolitis in children. A case of severe pseudomembranous colitis developing in an 8-year-old child who had received oral ciprofloxacin therapy as part of an investigational protocol is presented. The safety and efficacy of fluoroquinolones in children has not yet been established. Use of these antibiotics in children outside investigational protocols ("off-label" use) as oral antipseudomonas agents is discouraged.
Angel
Carlos A
CA
Department of Surgery (Pediatric Surgery), The University of Texas Medical Branch, Galveston, TX 77555-0353, USA.
Green
Justtin
J
Swischuk
Leonard
L
Patel
Janak
J
D000890:Anti-Infective Agents / Q000009:adverse effects*; D019072:Antibiotic Prophylaxis / Q000009:adverse effects*; D002648:Child; D002939:Ciprofloxacin / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D016360:Clostridioides difficile / Q000302:isolation & purification; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000382:microbiology; D006801:Humans; D008297:Male; D014513:Ureter / Q000601:surgery; D014552:Urinary Tract Infections / Q000150:complications / Q000601:surgery; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000601:surgery
D000890:Anti-Infective Agents; D002939:Ciprofloxacin