Translation silenced by fused pair of tRNA synthetases.
In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory response.
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Paul
P
Schimmel
Karla
K
Ewalt
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D002570:Ceruloplasmin / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D020868:Gene Silencing; D007371:Interferon-gamma / Q000378:metabolism; D014176:Protein Biosynthesis
D007371:Interferon-gamma; D002570:Ceruloplasmin; D000604:Amino Acyl-tRNA Synthetases; C415462:glutamyl-prolyl-tRNA synthetase