Transformation of 2-aminoacetophenone to ( S) -2-amino-1-phenylethanol by Arthrobacter sulfureus.
A new isolate of Arthrobacter sulfureus , when incubated at 50 g resting cells (dry cell wt) l(-1) with 50 g glucose l(-1) and 1 g 2-aminoacetophenone l(-1) in 50 mm potassium buffer (pH 7, 4 ml) at 30 degrees C, produced ( S )-2-amino-1-phenylethanol (e.e. >99%) with 75% yield in 6 h.
Zhao
Guogang
G
State Key Laboratory of Microorganism Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China.
Wang
Jianjun
J
Ma
Kai
K
Yang
Liu
L
Wu
Sheng
S
Liu
Yanbin
Y
Sun
Wanru
W
D000098:Acetophenones / Q000378:metabolism*; D001173:Arthrobacter / Q000145:classification / Q000254:growth & development* / Q000378:metabolism*; D001711:Biotransformation; D018929:Cell Culture Techniques / Q000379:methods*; D049109:Cell Proliferation; D019075:Electrophoresis, Capillary / Q000379:methods*; D005947:Glucose / Q000378:metabolism; D010626:Phenylethyl Alcohol / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D017680:Potassium Compounds / Q000378:metabolism; D012988:Soil Microbiology
D000098:Acetophenones; D010710:Phosphates; D017680:Potassium Compounds; C055495:2-aminoacetophenone; C013216:potassium phosphate; D005947:Glucose; D010626:Phenylethyl Alcohol