Anuric renal failure associated with zinc toxicosis in a dog.
The development of anuric renal failure associated with zinc intoxication was detected in a dog following ingestion of an ornamental brass knob from a toilet paper holder. The 3-y-old, male neutered, 15.4 kg Welsh Corgi presented to a local veterinary clinic with a 2-w history of intermittent vomiting, inappetance and lethargy. The dog was transferred to a veterinary teaching hospital where surgery was performed to remove the foreign body. The dogwas euthanized 24 h post-surgery due to the development of anuric renal failure. Whole blood drawn at the time of surgery had a serum zinc concentration of 89.8 ppm (normal 0.7-2.0 ppm). The serum zinc concentration in this dog is the highest reported concentration in the literature. Ingestion of any zinc-containing metal object can potentially result in a severe intravascular hemolysis with subsequent renal impairment. Zinc intoxication should be suspected when hemolysis is accompanied by the finding of a metallic object in the gut.
Veterinary Diagnostic Laboratory, 3836 VMBSB, 2001 S Lincoln Avenue, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, 61802, USA.
Petra A
PA
Volmer
Jennifer
J
Roberts
Gavin L
GL
Meerdink
D000818:Animals; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology*; D004285:Dogs; D005547:Foreign Bodies / Q000601:surgery / Q000662:veterinary*; D006461:Hemolysis; D008297:Male; D051437:Renal Insufficiency / Q000209:etiology* / Q000662:veterinary*; D015032:Zinc / Q000506:poisoning*
D015032:Zinc