Investigation of antioxidant status in children with acute otitis media and tonsillitis.
OBJECTIVE
Antioxidant enzymes status was investigated in children with acute otitis media (AOM) and acute tonsillitis. The aim was to determine the effect of oxidative damage due to free radicals on the antioxidant enzymes status in children with AOM and acute tonsillitis.


METHODS
We measured erythrocyte levels of superoxide dismutase and glutathione peroxidase (GPx) and activity of serum catalase, ceruloplasmin, albumin and total bilirubin in 23 children with AOM, 27 with acute tonsillitis and 17 control subjects.


RESULTS
There was statistically significant difference between the groups for all parameters. All antioxidant activities except for albumin level were increased in the studies groups. When the values of AOM and acute tonsillitis were compared, there was statistically significant difference between the groups for erythrocyte GPx.


CONCLUSIONS
Our findings indicate that not only a few antioxidant enzymes but almost all antioxidant activities showed a significant enhancement in children with AOM and acute tonsillitis.
Department of Biochemistry, Faculty of Science and Arts, Afyon Kocatepe University, Afyon, Turkey. mcemek@yahoo.com
Mustafa
M
Cemek
Hüseyin
H
Caksen
Fatma
F
Cemek
Fahri
F
Bayiroğlu
Semiha
S
Dede
Haluk
H
Dülger
Ramazan
R
Ustün
D000208:Acute Disease; D001663:Bilirubin / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D012016:Reference Values; D012709:Serum Albumin / Q000032:analysis; D014069:Tonsillitis / Q000378:metabolism*
D012709:Serum Albumin; D010088:Oxidoreductases; D001663:Bilirubin