Homer-PIKE complex: a novel link between mGluRI and PI 3-kinase.
Metabotropic glutamate (mGlu) receptors, a family of G-protein-coupled receptors, are thought to signal through the phospholipase and inositol (1,4,5)-trisphosphate receptor system, or through the adenylyl cyclase and protein kinase C system. Rong et al. have recently identified a new phosphoinositide (PI) 3-kinase enhancer (PIKE-L) that links group I mGlu receptors (mGluRI) to PI 3-kinase through Homer proteins, adaptors that bind mGluRI. mGluRI agonists enhanced mGluRI-Homer-PIKE-L complex formation, leading to activation of PI 3-kinase and inhibition of staurosporine-induced neuronal apoptosis. These results reveal a novel anti-apoptotic signaling mechanism that involves formation of an mGluRI signaling complex.
Section on Neural Development and Plasticity, NICHD/NIH, Bethesda, MD 20892-4480, USA.
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Guhan
Bai
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Lu
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000378:metabolism*; D000072233:Homer Scaffolding Proteins; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000737:chemistry / Q000378:metabolism*
D002352:Carrier Proteins; D020690:GTPase-Activating Proteins; D000072233:Homer Scaffolding Proteins; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; D019869:Phosphatidylinositol 3-Kinases; C485997:AGAP2 protein, human; D019204:GTP-Binding Proteins