Topical treatment of atopic dermatitis.
Topical therapy of atopic dermatitis should incorporate an understanding of the underlying immune abnormalities of this complex chronic skin disease. Avoidance of irritants and proven allergens, skin hydration, and use of emollients and anti-inflammatory therapy help maintain a normal skin barrier. Topical calcineurin inhibitors have been added to the topical treatment armamentarium. Although the optimal treatment approach remains to be defined, several studies suggest the use of topical calcineurin inhibitors as early intervention therapy and topical corticosteroids as rescue therapy.
Boguniewicz
Mark
M
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado School of Medicine, 1400 Jackson Street, Room J310, Denver, CO 80206, USA. boguniewiczm@njc.org
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D065095:Calcineurin Inhibitors; D002986:Clinical Trials as Topic; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D006801:Humans; D016559:Tacrolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000305:Adrenal Cortex Hormones; D065095:Calcineurin Inhibitors; C117268:pimecrolimus; D016559:Tacrolimus