Judging a virus by its cover.
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Eva
E
Szomolanyi-Tsuda
Raymond M
RM
Welsh
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology; D051379:Mice; D009500:Neutralization Tests; D012367:RNA, Viral; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000276:immunology; D014771:Virion / Q000235:genetics / Q000276:immunology
D000914:Antibodies, Viral; D008562:Membrane Glycoproteins; D012367:RNA, Viral; D014759:Viral Envelope Proteins