Evasive maneuvers by secreted bacterial proteins to avoid innate immune responses.
To cause disease, bacterial pathogens must first breach physical barriers, such as the mucous membrane that lines organs, and then successfully replicate and disseminate while avoiding destruction by the immune system. Many bacterial pathogens accomplish this by secreting proteins into their host environment, which act to subvert or dampen the expanding immune response. Here, we discuss how bacterial pathogens use an arsenal of secreted virulence proteins to modify the outcome of innate immune activation by altering how the immune system recognizes microbial invaders.
Michael Smith Laboratories, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Brian K
BK
Coombes
Yanet
Y
Valdez
B Brett
BB
Finlay
D001419:Bacteria / Q000276:immunology* / Q000378:metabolism / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology*; D001426:Bacterial Proteins / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D018448:Models, Immunological; D010587:Phagocytosis / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors; D023084:alpha-Defensins / Q000276:immunology
D001426:Bacterial Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D023084:alpha-Defensins