Intratympanic corticosteroids for Meniere's disease and vertigo.
Hearing loss can be caused by acoustic trauma, aging, ototoxic medications, and various other causes. At the cellular level hearing loss seems to be mediated by reactive oxygen species and ultimately through the activation of apoptotic mechanisms. This article explains the cellular and molecular mechanisms of hearing loss and presents medications that could be used in the intratympanic treatment of hearing loss.
Barrs
David M
DM
Department of Otolaryngology Head and Neck Surgery/Audiology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA. barrs.david@mayo.edu
D000287:Administration, Topical; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008575:Meniere Disease / Q000188:drug therapy*; D012405:Round Window, Ear / Q000378:metabolism; D014432:Tympanic Membrane / Q000601:surgery; D014717:Vertigo / Q000188:drug therapy*
D005938:Glucocorticoids