The effects of hydroxyurea on PRV-1 expression in patients with essential thrombocythemia and polycythemia vera.
The study was designed to investigate the influence of hydroxyurea (HU) treatment on PRV-1 expression. Eighteen newly diagnosed patients with essential thrombocythemia (ET) or polycythemia vera (PV) were included. HU significantly increased PRV-1 gene expression in the early stage of treatment.
Johansson
Peter
P
Ricksten
Anne
A
Wasslavik
Carina
C
Johansson
Berit
B
Andréasson
Björn
B
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D003199:Computer Systems; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology* / Q000627:therapeutic use; D007519:Isoantigens / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D010976:Platelet Count; D011087:Polycythemia Vera / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000097:blood*; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013920:Thrombocythemia, Essential / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D015854:Up-Regulation / Q000187:drug effects*
D015415:Biomarkers; C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D007519:Isoantigens; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D006918:Hydroxyurea