Expression of genes coding melatonin and serotonin receptors in rodent skin.
Targeted search for expression of melatonin and serotonin receptors genes in the skin of C57BL/6J mice showed expression of MT1B (but not MT1A). Mouse skin and hamster melanomas also expressed 5HT2B and 5HT7. We identified two novel isoforms of MT1A and 5HT7.
Slominski
Andrzej
A
Department of Pathology, University of Tennessee Health Science Center, 930 Madison Ave., Room 519, Memphis, TN 38163, USA. aslominski@utmem.edu
Pisarchik
Alexander
A
Wortsman
Jacobo
J
D000818:Animals; D006224:Cricetinae; D005260:Female; D005786:Gene Expression Regulation; D008544:Melanocytes / Q000166:cytology / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D044094:Receptors, Melatonin / Q000235:genetics* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D044094:Receptors, Melatonin; D011985:Receptors, Serotonin