Effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs.
The effects of cyclic AMP increasing cardiotonics (dopamine, dobutamine, amrinone and milrinone) on the blood flow in most organs were compared using colored microsphere technique in isoflurane-anesthetized dogs. Dopamine increased blood flow in ventricular myocardium. Furthermore dopamine induced the increase in blood flow in intestine and kidney at low to middle dose, but not at high dose. Dobutamine induced the highest increase in blood flow in ventricular myocardium and skeletal muscle among the drugs evaluated at middle and high doses. Amrinone and milrinone increased blood flow in ventricular myocardium almost same with catecholamines, and milrinone decreased vascular resistance moderately in most other organs. Milrinone might be more useful than catecholamines for improvement of congestive heart failure or peripheral circulatory failure accompanied with exceeded vasoconstriction.
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Denji
D
Tobata
Koji
K
Takao
Manabu
M
Mochizuki
Ryohei
R
Nishimura
Nobuo
N
Sasaki
D000676:Amrinone / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002395:Catecholamines / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D004064:Digestive System / Q000098:blood supply; D004280:Dobutamine / Q000494:pharmacology; D004285:Dogs / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology; D005123:Eye / Q000098:blood supply; D007530:Isoflurane; D008168:Lung / Q000098:blood supply; D008863:Microspheres; D020105:Milrinone / Q000494:pharmacology; D018482:Muscle, Skeletal / Q000098:blood supply; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
D002316:Cardiotonic Agents; D002395:Catecholamines; D010726:Phosphodiesterase Inhibitors; D004280:Dobutamine; D007530:Isoflurane; D020105:Milrinone; D000676:Amrinone; D004298:Dopamine