Effects of lesions of the human posterior thalamus on ocular fixation during voluntary and visually triggered saccades.
OBJECTIVE
To investigate the role of the posterior thalamus in controlling voluntary and visually triggered eye movements and ocular fixation.


METHODS
The latency to initiate saccades to peripheral targets (visually triggered) and in response to verbal commands (voluntary) was measured in three patients with unilateral lesions of the posterior thalamus, in normal controls, and in neurological controls with Parkinson's disease. On half the trials a fixation point offset simultaneously with target onset, and on half it remained visible.


RESULTS
Offset of the fixation point simultaneous with target onset decreased saccade latency for both voluntary and visually triggered eye movements in controls, but only for voluntary saccades in patients with thalamic lesions.


CONCLUSIONS
These findings suggest that separate neural systems control fixation when making voluntary and visually triggered eye movements, and that the thalamus is involved in the control of fixation for visually triggered but not for voluntary saccades.
Centre for Cognitive Neuroscience, University of Wales, Bangor, UK. r.rafal@bangor.ac.uk
R
R
Rafal
M
M
McGrath
L
L
Machado
J
J
Hindle
D000368:Aged; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D002543:Cerebral Hemorrhage / Q000503:physiopathology*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology*; D006801:Humans; D018476:Hypokinesia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology; D010775:Photic Stimulation; D020656:Posterior Thalamic Nuclei / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012438:Saccades / Q000502:physiology*; D013786:Thalamic Diseases / Q000503:physiopathology*