Isoniazid acetylation phenotyping in Saudi Arabs.
OBJECTIVE
The present study is designed to investigate the acetylator status in Saudi Arabs.


METHODS
Isoniazid (INH) acetylation phenotyping was studied in 136 Saudi Arabs in Riyadh, Saudi Arabia, using a single plasma sample taken 3 h post-INH oral dose of 200 mg. Metabolic ratio (MR) of plasma acetyl-INH (Ac-INH) to INH was used to determine the acetylation phenotype.


RESULTS
The MR had a bimodal distribution with an antimode of 1.0. The frequency distribution of slow acetylators (MR < 1.0) was 94.9% (n = 129). Using Hardy-Weinberg Law, the gene frequency (q) of the recessive allele determining slow acetylator phenotype was found to be 0.97.


CONCLUSIONS
INH phenotyping suggests a high frequency of slow acetylators among Saudi Arabs. There was no association between the MR of plasma Ac-INH/INH and age or gender.
Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat. kamal@hsc.kuniv.edu.kw
K M
KM
Matar
A Y
AY
Mayet
E A
EA
Ayoola
S A
SA
Bawazir
F Z
FZ
Al-Faleh
A
A
Al-Wazzan
D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics* / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007538:Isoniazid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012529:Saudi Arabia
D000995:Antitubercular Agents; D000123:Acetyltransferases; D007538:Isoniazid