Pharmacoepidemiology and rheumatic disorders.
This article reviews the application of pharmacoepidemiology in the evaluation of drugs that are used commonly for rheumatic disorders. Data sources and methodology considerations for these studies are highlighted. The topics that are covered included the safety evaluation of nonsteroidal ant-inflammatory drugs, adverse pregnancy outcomes of pharmaceutical agents, gastroduodenal safety of alendronate, long-term beneficial effects of methotrexate for rheumatoid arthritis, and drug use study.
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA. kachan@hsph.harvard.edu
K Arnold
KA
Chan
Sonia
S
Hernandez-Diaz
D018501:Antirheumatic Agents / Q000627:therapeutic use; D004363:Drug Utilization; D005260:Female; D006801:Humans; D008297:Male; D017891:Pharmacoepidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012216:Rheumatic Diseases / Q000188:drug therapy* / Q000453:epidemiology*
D018501:Antirheumatic Agents