Vasohibin: the feedback on a new inhibitor of angiogenesis.
Angiogenesis is regulated in large part by the balance of various proangiogenic stimulators, such as VEGF, and a diverse group of endogenous inhibitors of angiogenesis, most of which are extrinsic to endothelial cells. With respect to the latter, until recently, none have appeared to be induced as a consequence of a specific, self-regulating, feedback inhibition response. A new inhibitor, called vasohibin, has been uncovered. Vasohibin is selectively induced in endothelial cells by proangiogenic stimulatory growth factors such as VEGF; it appears to operate as an intrinsic and highly specific feedback inhibitor of activated endothelial cells engaged in the process of angiogenesis.
Kerbel
Robert S
RS
Sunnybrook and Women's College Health Sciences Centre and the University of Toronto, Ontario, Canada. robert.kerbel@swchsc.on.ca
D020533:Angiogenesis Inhibitors / Q000378:metabolism*; D000818:Animals; D018797:Cell Cycle Proteins; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018919:Neovascularization, Physiologic; D011506:Proteins / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D018797:Cell Cycle Proteins; D011506:Proteins; C493181:VASH1 protein, human; D042461:Vascular Endothelial Growth Factor A