Reprogramming DNA-directed reactions on the basis of a DNA conformational change.
A strategy has been developed for switching chemical reactions between two identical reagents on the basis of DNA duplex-triplex transition. In response to the change of solution pH, a DNA complex changes its conformation and repositions chemical reagents that are conjugated with DNA strands. As a result, chemical reactions are reprogrammed. This strategy is expected to be applicable to sophisticated chemical syntheses.
Chen
Yi
Y
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Mao
Chengde
C
D000215:Acylation; D000588:Amines / Q000737:chemistry* / Q000378:metabolism; D002264:Carboxylic Acids / Q000737:chemistry* / Q000378:metabolism; D003596:Cytosine / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D006863:Hydrogen-Ion Concentration; D009690:Nucleic Acid Conformation; D013329:Structure-Activity Relationship
D000588:Amines; D002264:Carboxylic Acids; C051802:triplex DNA; D003596:Cytosine; D004247:DNA