[RGS proteins (regulators of G protein signaling) and their roles in regulation of immune response].
RGS proteins (Regulators of G-protein Signaling) comprise a protein family responsible for regulating G proteins. By enhancing the GTPase activity of the a subunit, they speed up the reconstruction of the heterotrimeric structure of G protein, thus inhibiting its signal transduction. Sst2 protein in yeast Saccharomyces cervisiae, FlbA in fungus Aspergillus nidulans, and Egl-10 in the nematode Caenorhabditis elegans are the first native G regulators with GTPase activity (GAPs:--GTPase-activating proteins). The existence of over 30 RGS human proteins has been confirmed thus far, and they have been grouped and classified into six subfamilies. In immunocompetent cells, RGS proteins are entangled in a complicate net of different interrelating signal pathways. They are connected with B- and T-cell chemokine susceptibility, efficient T cell proliferation, and the regulation of B cell maturation. They also take an essential part in inflammation. High hopes are held for drugs, which handle would be RGS proteins and which would further provide the possibility of modifying the pharmacokinetics of drugs acting through G protein- coupled receptors. The aim of this review is to discuss the new RGS protein family and explain the potential involvement of RGS proteins in the modulation of the immune response
Katedra i Zakład Immunologii Klinicznej, Uniwersytetu Medycznego w Łodzi. anulka_pl@poczta.onet.pl
Anna M
AM
Lewandowicz
Marek L
ML
Kowalski
Rafał
R
Pawliczak
D000818:Animals; D001233:Aspergillus nidulans / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D017173:Caenorhabditis elegans / Q000276:immunology; D019204:GTP-Binding Proteins / Q000276:immunology; D020690:GTPase-Activating Proteins / Q000378:metabolism; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D020710:RGS Proteins / Q000145:classification* / Q000276:immunology*; D012441:Saccharomyces cerevisiae / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D020690:GTPase-Activating Proteins; D020710:RGS Proteins; D019204:GTP-Binding Proteins