Cardio: a web-based knowledge resource of genes and proteins related to cardiovascular disease.
BACKGROUND
Cardiovascular disease (CVD) is the leading killer for human. In order to understand the linkage between cardiovascular diseases and genes or proteins, it is essential to construct a database to organize the body of knowledge. While the existing molecular biological databases focus on the sequence and structural aspects of biological macromolecules, i.e. DNAs, RNAs and proteins, Cardio is the web-based system we built to provide a knowledge environment with visual interface to integrate information about major cardiovascular diseases in relation to genes and proteins.


METHODS
We collected the information from the web by using a group of software we developed and used a relational database management system to manage the information of these data.


RESULTS
Cardio consists of six sections: GENE, PROTEIN, DISEASE, DRUG, LINKS, and REFERENCE. Each section contains relevant information about the topic. Using a phenotype-driven approach, we can identify genetic mechanisms underlying the physiology and pathophysiology of specific cardiovascular disease, such as atherosclerosis, hypertension, heart failure, and stroke.


CONCLUSIONS
The website titled "Database of Genes and Proteins Related to Cardiovascular Disease (Cardio)" is available at along with additional information on cardiovascular disease, supplementary materials and related figures.
Zhang
Qipeng
Q
Institute of Cardiovascular Sciences, Peking University, Beijing, China. zhang7peng@163.com
Lu
Ming
M
Shi
Lei
L
Rui
Wei
W
Zhu
Xiaohua
X
Chen
Guanghui
G
Shang
Tong
T
Tang
Jian
J
D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D003196:Computer Graphics; D003628:Database Management Systems; D030541:Databases, Genetic; D006801:Humans; D020407:Internet; D011506:Proteins / Q000502:physiology*; D018511:Systems Integration
D011506:Proteins