Ethics of testicular stem cell medicine.
The ethical issues raised by advances in reproductive technology allowing the transplantation of testicular stem cells to enable infertile men and cancer patients, including the pre-pubertal, to have children, and to provide new contraceptive prospects for fertile men are discussed. Consideration of respect for the patient's autonomy, the need for informed consent and the health of any offspring resulting from such a procedure are included. Topics covered include: the problems raised by cases needing consent for the transplantation of testicular stem cells from pre-pubertal and adolescent patients; the legal status of stem cells; the arguements for treating such tissue as property which might serve as a means of guaranteeing respect for patients' rights in disputed cases; aspects of patents and the ethics of allowing commercial traffic of such material; questions relating to health and safety, as well as xenotransplantation technology in humans; and posthumous procurement use of germ cells from minors. Proposals are made to enhance informed and effective consent, while supporting patient determination, choice, autonomy and technological advances. The paper appeals to the emerging EU directives in relation to tissue procurement, storing and use of tissue and cells to adopt a pragmatic and meaningful position which will help enhance patient determination and autonomy in relation to the emerging technologies in reproductive medicine, whilst providing a pragmatic way forward for fertility clinics and laboratories to function.
Bahadur
G
G
Department of Obstetrics and Gynaecology, Fertility and Reproductive Medicine Laboratories, Royal Free and University College Medical School, 25 Grafton Way, London WC1E 6DB, UK. g.bahadur@ucl.ac.uk
D004992:Ethics, Medical; D005060:Europe; D006806:Human Rights; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000628:therapy*; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000628:therapy; D010330:Patents as Topic; D011627:Puberty; D027724:Reproductive Techniques, Assisted / Q000941:ethics*; D033581:Stem Cell Transplantation / Q000941:ethics* / Q000331:legislation & jurisprudence; D013234:Stem Cells / Q000502:physiology*; D013737:Testis / Q000166:cytology*; D014021:Tissue Preservation / Q000379:methods / Q000639:trends