Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction.
Signaling by receptors in the TNF receptor (TNFR) superfamily mediate biological outcomes ranging from inflammation to apoptosis and other forms of programmed cell death. How receptor signaling mediates these divergent responses is just beginning to be understood. Here, we discuss how receptor submembrane localization and the formation of alternate signaling complexes can alter the fate of cells stimulated through TNFRs with a death domain, also known as "death receptors."
Muppidi
Jagan R
JR
Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Tschopp
Jürg
J
Siegel
Richard M
RM
D000818:Animals; D016923:Cell Death / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D018124:Receptors, Tumor Necrosis Factor