Understanding carbohydrate-carbohydrate interactions by means of glyconanotechnology.
Carbohydrate-carbohydrate interaction is a reliable and versatile mechanism for cell adhesion and recognition. Glycosphingolipid (GSL) clusters at the cell membrane are mainly involved in this interaction. To investigate carbohydrate-carbohydrate interaction an integrated strategy (Glyconanotechnology) was developed. This strategy includes polyvalent tools (gold glyconanoparticles) mimicking GSL clustering at the cell membrane as well as analytical techniques such as AFM, TEM, and SPR to evaluate the interactions. The results obtained by means of this strategy and current status are presented.
de la Fuente
Jesus M
JM
Grupo Carbohidratos, Laboratory of Glyconanotechnology IIQ-CSIC, Américo Vespucio s/n, 41092 Sevilla, Spain.
Penadés
Soledad
S
D015374:Biosensing Techniques; D006001:Glycoconjugates / Q000378:metabolism*; D006046:Gold; D007700:Kinetics; D018625:Microscopy, Atomic Force; D008854:Microscopy, Electron; D049329:Nanostructures; D036103:Nanotechnology; D011134:Polysaccharides / Q000378:metabolism*; D020349:Surface Plasmon Resonance
D006001:Glycoconjugates; D011134:Polysaccharides; D006046:Gold