Suppression of inferior alveolar nerve-induced vasoconstrictor response by ongoing cervical sympathetic nerve activity in cat.
We examined the effects of ongoing cervical sympathetic trunk (CST) stimulation on the vasoconstrictor responses in the lower lip elicited by electrical stimulation (ES) of the inferior alveolar nerve (IAN) or CST in anaesthetised cats to determine whether (i) the previously reported suppressive effect of ongoing CST activity on IAN-induced vasoconstriction occurs during not only ipsilateral, but also contralateral CST stimulation; and (ii) a vasoconstriction can be elicited by brief CST stimulation during ongoing stimulation of the contralateral CST. The central lower lip blood vessels are innervated by both left and right CST. The fall in central lip blood flow (LBF) elicited by IAN stimulation alone was reduced in a frequency-dependent manner during concurrent CST stimulation at 0.2-2 Hz, and at the high end of this frequency range was transformed to a rise regardless of whether the CST stimulation was ipsilateral or contralateral to the IAN stimulation. The fall in central LBF elicited by stimulation of one CST was not transformed to a rise by ongoing stimulation of the contralateral CST. Possibly, IAN-evoked orofacial vasoconstriction does not occur under physiological conditions (unlike IAN-evoked vasodilatation) because it is suppressed by the spontaneous sympathetic discharge in CST.
Department of Oral Physiology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan. izumih@hoku-iryo-u.ac.jp
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D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D008046:Lip / Q000098:blood supply* / Q000502:physiology; D008297:Male; D008340:Mandibular Nerve / Q000502:physiology*; D012039:Regional Blood Flow; D013562:Sympathectomy / Q000379:methods; D013564:Sympathetic Nervous System / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology*; D014664:Vasodilation