[Major hypoglycemia during malaria outburst treated by quinine: importance of glucagon].
An efficient quinine therapy administered for the treatment of severe malaria has induced a major hypoglycemia in a pregnant woman. Glycemia varied from 0.3 to 0.6 g/l (normal: 0.7-1.1 g/l) despite symptoms correction by infusion of 2.51 of hypertonic glucose serum at 30% per day. The continuous infusion of glucagon: 1 mg diluted in 50 cm3 of physiological saline solution, at 0.5 to 6 ml/h rate has allowed a normal glycemia value and quinine therapy was carried on until the 7th day.
Service de réanimation chirurgicale CHU HJRA Ampefiloha, 101 Antananarivo, Madagascar. mpanjato@yahoo.com
M R
MR
Rasoloherimampiononiaina
D000328:Adult; D000962:Antimalarials / Q000009:adverse effects*; D005260:Female; D005934:Glucagon / Q000627:therapeutic use*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced* / Q000188:drug therapy*; D016778:Malaria, Falciparum / Q000188:drug therapy*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011803:Quinine / Q000009:adverse effects*
D000962:Antimalarials; D005934:Glucagon; D011803:Quinine