Evaluation of antitussive activity of Lagerstroemia parviflora leaf extract.
The methanol extract of the leaves of Lagerstroemia parviflora Roxb was investigated for its effect on a cough model induced by sulfur dioxide gas in mice. It exhibited significant antitussive activity when compared with the control in a dose-dependent manner. The L. parviflora extract (100, 200, 300 mg/kg) showed maximum inhibition of cough reflex at 90 min after drug administration and the antitussive activity was comparable to that of codeine phosphate, a standard antitussive agent.
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, India. avijitmazum@yahoo.com
Avijit
A
Mazumder
B P
BP
Saha
S P
SP
Basu
Rupa
R
Mazumder
R
R
Boominathan
B Parimala
BP
Devi
S C
SC
Mandal
D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D031563:Lagerstroemia; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D013458:Sulfur Dioxide
D000996:Antitussive Agents; D010936:Plant Extracts; D013458:Sulfur Dioxide