Id3 knockout mice as a new model for sjogren's syndrome: only a T cell defect or more?
Id3(-/-) mice were found to have autoantibodies, lymphocytic infiltrates in, and decreased secretion by exocrine glands. Similar symptoms are found in primary Sjogren's Syndrome. In this issue of Immunity, Li and colleagues suggest an important role for Id3 function in T cell development and Sjogren's Syndrome.
Department Immunology, Erasmus MC, Rotterdam, The Netherlands.
Marjan A
MA
Versnel
D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins / Q000502:physiology*; D012859:Sjogren's Syndrome / Q000235:genetics*; D013601:T-Lymphocytes / Q000502:physiology*
D009363:Neoplasm Proteins