Voriconazole-induced QT interval prolongation and ventricular tachycardia: a non-concentration-dependent adverse effect.
A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non-concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment.
Infectious Diseases Unit, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel-Aviv University, Israel.
Y
Y
Alkan
W E
WE
Haefeli
J
J
Burhenne
J
J
Stein
I
I
Yaniv
I
I
Shalit
D000293:Adolescent; D000935:Antifungal Agents / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced*; D005260:Female; D005670:Fusarium; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D009894:Opportunistic Infections / Q000188:drug therapy; D011743:Pyrimidines / Q000009:adverse effects*; D017180:Tachycardia, Ventricular / Q000139:chemically induced*; D016171:Torsades de Pointes / Q000139:chemically induced; D014230:Triazoles / Q000009:adverse effects*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole