Unsaturated 1,2-amino alcohols and ethers from aziridines and organolithiums.
Organolithium-induced ring-opening of aziridines of 2,5-dihydrofuran (5 and 8) and 1,4-dimethoxybut-2-ene (16, 17 and 23) gives 3-substituted 2-aminobut-3-en-1-ols 9-15 and amino ethers 18-20 and 24-26.
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UKOX1 3TA. david.hodgson@chem.ox.ac.uk
David M
DM
Hodgson
Bogdan
B
Stefane
Timothy J
TJ
Miles
Jason
J
Witherington