A pilot study of the relationship between selective serotonin reuptake inhibitors and in vitro fertilization outcome.
In a retrospective chart review study women taking selective serotonin reuptake inhibitors antidepressants were compared with a matched comparison group to determine whether there were any differences in IVF outcome-related variables. There were no significant differences between the groups in peak E(2), number of oocytes retrieved, number of oocytes fertilized, percentage of 8-cell or blastocysts developed, day of transfer, or initial hCG values; however, 40% of women taking selective serotonin reuptake inhibitors had ongoing pregnancies compared to 51% of women not taking selective serotonin reuptake inhibitors.
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois, USA. sck318@northwestern.edu
Susan C
SC
Klock
Sandra
S
Sheinin
Ralph
R
Kazer
Xingqi
X
Zhang
D047108:Embryonic Development / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D009865:Oocytes / Q000254:growth & development; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
D004958:Estradiol; D017367:Selective Serotonin Reuptake Inhibitors