High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide.
A novel continuous-flow scCO(2) process for kinetic resolution of racemic alcohols can be performed with an immobilized lipase to lead to a quantitative mixture of the corresponding optically active acetates with up to 99% ee and unreacted alcohols with up to 99% ee, in which the productivity of the optically active compounds was improved by over 400 times compared to the corresponding batch reaction using scCO(2).
Department of Materials Chemistry, Ryukoku University, Otsu, Shiga 520-2194, Japan.
Tomoko
T
Matsuda
Kazunori
K
Watanabe
Tadao
T
Harada
Kaoru
K
Nakamura
Yoshitaka
Y
Arita
Yukihiro
Y
Misumi
Shinichiro
S
Ichikawa
Takao
T
Ikariya
D000438:Alcohols / Q000737:chemistry* / Q000302:isolation & purification; D002175:Candida / Q000201:enzymology; D002245:Carbon Dioxide / Q000737:chemistry*; D007700:Kinetics; D008049:Lipase / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D002245:Carbon Dioxide; D008049:Lipase