Role of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the development of hypertensive organ damage.
Recently, a novel endothelial oxidized low-density lipoprotein (LDL) receptor, lectin-like oxidized LDL receptor (LOX)-1, has been identified by the expression cloning of cultured bovine aortic endothelial cells (BAEC). The experimental evidence has suggested that LOX-1 may contribute to the development of vascular injury. For example, LOX-1 is upregulated in aorta from hypertensive, diabetic, and hyperlipidemic model animals. Also, LOX-1 overexpression is observed in atherosclerotic regions and damaged kidneys. In hypertensive animals, not only antihypertensive drugs but also antioxidant agents suppress the LOX-1 overexpression. Peroxisome proliferator-activated receptor-gamma (PPARgamma) activators inhibit cytokine-stimulated LOX-1 expression, possibly through their antioxidant effects, while, in contrast, LOX-1 generates reactive oxygen species (ROS). Therefore, ROS may play an important role in both the expression and function of LOX-1.
Department of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Katsuyuki
K
Ando
Toshiro
T
Fujita
D000818:Animals; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications* / Q000235:genetics* / Q000517:prevention & control; D007668:Kidney / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology; D047495:PPAR gamma / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism; D011973:Receptors, LDL / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; D013654:Taurine / Q000627:therapeutic use
C495137:OLR1 protein, human; D047495:PPAR gamma; D017382:Reactive Oxygen Species; D011973:Receptors, LDL; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; D013654:Taurine