REM sleep is impaired by a small amount of alcohol in young women sensitive to alcohol.
OBJECTIVE
The effect of a small amount of alcohol on the sleep structure in relation to alcohol sensitivity was examined using polysomnography (PSG).


METHODS
Alcohol sensitivity was evaluated using alcohol patch test for all subjects. PSGs were performed on three nights after one night for acclimation, and subjects consumed no alcohol, 0.28 or 0.69 g ethanol/kg body weight, respectively, before going to bed. The percentages of sleep time in each sleep stage of 1, 2, 3+4 and rapid eye movement (REM), REM latency, and REM cycle were calculated.


METHODS
Thirteen healthy female students (age 21.1 +/- 0.7 years) were enrolled in this study.


RESULTS
In all subjects, there were no significant differences in any of the sleep parameters between baseline night and alcohol nights. Six of the 13 subjects were sensitive to alcohol, in whom %stage REM was significantly decreased by alcohol consumption (baseline night: 18.3 +/- 6.2%, alcohol night I: 9.8 +/- 5.1% and alcohol night II: 11.0 +/- 2.8%), and the REM latency was significantly prolonged. The standard deviation of REM cycle was significantly greater on alcohol nights I and II than baseline night. There were no significant differences in other sleep parameters. In the other seven subjects who were insensitive to alcohol, none of the sleep parameters were significantly affected by alcohol consumption.


CONCLUSIONS
REM sleep was adversely affected by a small amount of alcohol in alcohol-sensitive healthy young women. Alcohol sensitivity might play some important role in impaired REM sleep by an ingestion of a small amount of alcohol.
Miyata
Seiko
S
Department of Pathophysiological Laboratory Sciences Nagoya University Graduate School of Medicine, 1-1-20 Daiko Minami, Higashi, Nagoya, Aichi 461-8673.
Noda
Akiko
A
Ito
Nami
N
Atarashi
Misaho
M
Yasuma
Fumihiko
F
Morita
Setsuko
S
Koike
Yasuo
Y
D000428:Alcohol Drinking / Q000009:adverse effects*; D019973:Alcohol-Related Disorders / Q000209:etiology*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D010328:Patch Tests; D017286:Polysomnography; D012893:Sleep Wake Disorders / Q000139:chemically induced* / Q000175:diagnosis; D012895:Sleep, REM / Q000187:drug effects*