Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly.
Eph receptor tyrosine kinases and ephrins have key roles in regulation of the migration and adhesion of cells required to form and stabilize patterns of cell organization during development. Activation of Eph receptors or ephrins can lead either to cell repulsion or to cell adhesion and invasion, and recent work has found that cells can switch between these distinct responses. This review will discuss biochemical mechanisms and developmental roles of the diverse cell responses controlled by Eph receptors and ephrins.
Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
Alexei
A
Poliakov
Marisa
M
Cotrina
David G
DG
Wilkinson
D000818:Animals; D019521:Body Patterning; D002448:Cell Adhesion; D002465:Cell Movement; D036342:Ephrins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D018919:Neovascularization, Physiologic; D009432:Neural Crest / Q000166:cytology; D036081:Receptors, Eph Family / Q000378:metabolism / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D036342:Ephrins; D036081:Receptors, Eph Family; D020928:Mitogen-Activated Protein Kinases; D020741:rho GTP-Binding Proteins