[Repair of the rabbit ear cartilage defects with transforming growth factor-beta1 and allogenic chondrocyte/poly-DL-lactide higher porosity polymer].
OBJECTIVE
To study the repair of the rabbit ear cartilage defects with transforming growth factor-beta1 (TGF-beta1) and allogenic chondrocyte/poly-DL-lactide (PDLLA) higher porosity polymer.


METHODS
A total of 18 rabbits were divided into the TGF-beta1 and chondrocytes/PDLLA graft group, the chondrocytes/PDLLA graft group, and the blank control group. Samples were taken out at 4, 12 and 18 weeks after implantation. The histological characteristics were investigated.


RESULTS
After 18 weeks of the transplantation, the repaired effects of TGF-beta1 and allogenic chondrocytes/PDLLA graft group was better than the allogenic chondrocytes/PDLLA graft group not only on general sample but also histology, and the blank control group were repaired with fibrous tissue.


CONCLUSIONS
The allogenic chondrocytes/PDLLA graft could repair the rabbit ear cartilage defects while TGF-beta1 could improve the quality of the rabbit ear cartilage defects.
Department of Otorhinolaryngology, First Military Medical University Zhujiang Hospital, Guangzhou 510282, China.
Jing-Hong
JH
Li
Jin-Zhong
JZ
Huang
Jiang
J
Du
You
Y
Cheng
D000818:Animals; D019902:Chondrocytes / Q000637:transplantation*; D004431:Ear, External / Q000293:injuries / Q000601:surgery*; D008297:Male; D011091:Polyesters / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits; D016212:Transforming Growth Factor beta / Q000008:administration & dosage* / Q000494:pharmacology; D053773:Transforming Growth Factor beta1; D014184:Transplantation, Homologous
D011091:Polyesters; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; C033616:poly(lactide)