Polyomaviruses and primary central nervous system lymphomas.
The authors investigated the potential association of human primary CNS non-Hodgkin lymphoma (PCNSL) with polyomavirus in HIV-1 infected and uninfected individuals. Immunohistochemical analysis of CNS biopsies from 19 HIV-negative and 17 HIV-positive patients and PCR analysis of 12 HIV-negative and 14 HIV-positive patients revealed that the lymphomas were uniformly negative for polyomaviruses. The authors conclude that polyomaviruses are unlikely to be related to the pathogenesis of most PCNSL.
Department of Pathology, Box 1143, Mount Sinai School of Medicine, New York, NY 11377, USA. jacinta.murray@mssm.edu
Jacinta M
JM
Murray
Susan
S
Morgello
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000957:Antigens, Viral, Tumor / Q000032:analysis; D002467:Cell Nucleus / Q000821:virology; D016543:Central Nervous System Neoplasms / Q000821:virology*; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011120:Polyomavirus / Q000276:immunology / Q000302:isolation & purification*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D000957:Antigens, Viral, Tumor; D016159:Tumor Suppressor Protein p53