Baseline risk factors for the development of primary open-angle glaucoma in the Ocular Hypertension Treatment Study.
OBJECTIVE
Higher baseline pattern standard deviation (PSD) and larger vertical cup-to-disk ratio (VC/D) were factors in the predictive model for the development of primary open-angle glaucoma (POAG) in the Ocular Hypertension Treatment Study. Because early changes in PSD and VC/D may be indicative of early POAG damage, we repeated the prediction model excluding PSD and VC/D.


METHODS
Reanalysis of baseline factors for the development of POAG.


METHODS
We compared the hazard ratios for baseline factors predictive of POAG in the multivariate Cox proportional hazards model that included PSD and VC/D and in the model that excluded them.


RESULTS
Hazard ratios for baseline factors predictive of POAG in Ocular Hypertension Treatment Study were not substantially affected by the inclusion or exclusion of PSD and VC/D in the proportional hazards model.


CONCLUSIONS
Whether PSD or VC/D was included in the Cox proportional hazards model, the same baseline factors were statistically significant and their hazard ratios were essentially similar.
Jules Stein Eye Institute, University of California, Los Angeles, USA.
Anne L
AL
Coleman
Mae O
MO
Gordon
Julia A
JA
Beiser
Michael A
MA
Kass
D005902:Glaucoma, Open-Angle / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007429:Intraocular Pressure; D008954:Models, Biological; D009798:Ocular Hypertension / Q000628:therapy; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors