Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia.
Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS.
Department of Radiology, Division of Research, Section of Imaging Science, 950 W. Walnut St., Research Institute 2, Room E124, Indianapolis, IN 46202, USA. kkyoder@iupui.edu
Karmen K
KK
Yoder
Gary D
GD
Hutchins
Evan D
ED
Morris
Allison
A
Brashear
Chunzi
C
Wang
Anantha
A
Shekhar
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001007:Anxiety / Q000175:diagnosis / Q000453:epidemiology; D001665:Binding Sites; D002421:Caudate Nucleus / Q000378:metabolism; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D003342:Corpus Striatum / Q000378:metabolism*; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology; D050483:Dopamine Plasma Membrane Transport Proteins; D004409:Dyskinesia, Drug-Induced / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D049268:Positron-Emission Tomography; D011699:Putamen / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism*
D014150:Antipsychotic Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human