DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus.
The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo.
Marzi
Andrea
A
Institute for Clinical and Molecular Virology, University Erlangen-Nürnberg, Nikolaus-Fiebiger-Center, Glückstrasse 6, D-91054 Erlangen, Germany.
Gramberg
Thomas
T
Simmons
Graham
G
Möller
Peggy
P
Rennekamp
Andrew J
AJ
Krumbiegel
Mandy
M
Geier
Martina
M
Eisemann
Jutta
J
Turza
Nadine
N
Saunier
Bertrand
B
Steinkasserer
Alexander
A
Becker
Stephan
S
Bates
Paul
P
Hofmann
Heike
H
Pöhlmann
Stefan
S
D015815:Cell Adhesion Molecules / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology*; D037181:Lectins, C-Type / Q000502:physiology*; D029024:Marburgvirus / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000502:physiology*; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000502:physiology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human; C578557:spike glycoprotein, SARS-CoV; C578553:spike protein, mouse hepatitis virus