Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves innate-defense capacity in healthy middle-aged people.
Different lactic acid bacteria have often been administered as a dietary means to enhance immune system activity. Based on this statement, the aim of the current work was to test the effects of a Lactobacillus casei DN114001 fermented milk consumption on the immune response capacity in middle-age volunteers. Forty-five healthy volunteers, 24 women and 21 men (aged: 51-58 years), were randomized into two groups to receive three cups per day of a L. casei DN114001 (10(8)-10(10) ufc/g) fermented milk (n = 23), or placebo (n = 22), during an 8-week period. Measurements were performed before (day 0), and after the nutritional intervention (day 56). After the trial, no changes in immune cell proportions were detected, but the probiotic-treated group increased oxidative burst capacity of monocytes (probiotic group: p = 0.029; placebo group: p = 0.625), as well as NK cells tumoricidal activity (probiotic group: p = 0.023; placebo group: p = 0.125). Results showed that daily intake of fermented milk containing Lactobacillus casei DN114001 could have a positive effect in modulating the innate immune defense in healthy-middle-age people.
Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain.
M D
MD
Parra
B E
BE
Martínez de Morentin
J M
JM
Cobo
A
A
Mateos
J A
JA
Martínez
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D005285:Fermentation; D005434:Flow Cytometry; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D020014:K562 Cells; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007780:Lacticaseibacillus casei / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008892:Milk / Q000382:microbiology*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D010919:Placebos; D019936:Probiotics; D016897:Respiratory Burst / Q000187:drug effects; D013997:Time Factors
D010919:Placebos