[Detection of antibodies against cytomegalovirus in donors and recipients of kidney transplants].
The paper analyzed the values and titer of IgM and IgG antibodies on CMV in donors and recipients of kidney transplntats. The objective was to investigate the presence of CMV in donors and recipients.


METHODS
Test enzignost anti CMV/IgM was used. Detection of antibodies in 15 donors before transplantation and in 22 patients-recipients before and after the transplantation was done.


RESULTS
From total of 15 donors, the values of IgM ranged from 0,002 I.U. do 0,080 I.U. One case was positive. Four patients were seropositive and treated by Gancyclovirom 10 mg/kg/b.w (body weight) in period of 3 month. IgM values ranged from 0.88399 to 25978. The control finding 3 patients was negative, in 1 patient positive (IgM 0.569). In 18 patients the finding was negative. Refererent value for IgM is < 0.10 the result is negative. For IgG four times greater value comparing to the basic value was found.


CONCLUSIONS
The most significant factor for reactivation of CMV infection is iatrogenic Immunosuppressive therapy. Exclusion of CMV infection in donors and negative finding in recipient decrease.
Zavod za Farmakologiju Medicinski Fakultet u Tuzli.
Jasenko
J
Karamehić
Mirsada
M
Hukić
Faris
F
Gavrankapetanović
Bećir
B
Heljić
Emir
E
Hodzić
Zineta
Z
Delibegović
Vanja
V
Karlović
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M