Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice.
The 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene was synthesized from N,N'-di(1-adamantyl)malondiamide and C(60) in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene. The intraperitoneal administration of this fullerene derivative (10mg/kg) caused an antagonistic effect on haloperidol-induced catalepsy in mice.
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Manabu
M
Nakazono
Shigeo
S
Hasegawa
Tsuneyuki
T
Yamamoto
Kiyoshi
K
Zaitsu
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology; D006220:Haloperidol; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure
C497852:61-bis(1-adamantylcarbamoyl)-1,2-methano(60)fullerene; D037741:Fullerenes; D006220:Haloperidol; D000218:Adamantane