Peptide/protein hybrid materials: enhanced control of structure and improved performance through conjugation of biological and synthetic polymers.
The conjugation of peptides/proteins and synthetic polymers is a useful strategy to overcome some of the limitations related to the use of the individual components. This review will highlight two aspects: enhanced structural control at the nanometer level and improved performance, in particular with respect to biomedical applications. In the former case, peptide sequences are mainly used to mediate self-assembly of synthetic polymers. In the latter case, conjugation of an appropriate synthetic polymer to a pharmaceutically active peptide/protein can, for example, prevent premature enzymatic degradation and enhance blood circulation times, which is therapeutically advantageous.
Max Planck Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany.
Guido W M
GW
Vandermeulen
Harm-Anton
HA
Klok
D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers; D015195:Drug Design; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011485:Protein Binding; D011487:Protein Conformation; D055503:Protein Multimerization; D011506:Proteins / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods
D016229:Amyloid beta-Peptides; D000970:Antineoplastic Agents; D004337:Drug Carriers; D010455:Peptides; D011506:Proteins