No argument for not accepting a single, well-performed trial for the highest level of recommendation.
John P
JP
Kepros
Moustafa
M
Hassan
D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine / Q000592:standards*; D006801:Humans; D017410:Practice Guidelines as Topic / Q000592:standards*; D012772:Shock, Septic / Q000628:therapy*; D018746:Systemic Inflammatory Response Syndrome / Q000628:therapy*