Cell signalling and motility in Entamoeba histolytica.
Entamoeba histolytica crawls as a polarized cell following external stimuli, with the translocation of signals modifying extracellular matrix interactions and the amoeba cytoskeleton. Nancy Guillén here describes how the gliding of E. histolytica cells requires the activity of the actomyosin complex, and how actomyosin functions related to motility are necessary for pathogenesis and for amoebal escape from the host immune response.
Unité de Pathogénie Microbienne Moléculaire, U199 INSERM, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cédex 15, France.
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