The influence of some antipsychotics on erythrocyte magnesium and plasma magnesium, calcium, copper and zinc in patients with paranoid schizophrenia.
OBJECTIVE
The aim of the study was the investigation of plasma magnesium, calcium, copper and zinc and erythrocyte magnesium levels in patients with paranoid schizophrenia and the influence of the therapy with two antipsychotic drugs (haloperidol and risperidone) on these concentrations.


METHODS
We investigated the influence of treatment with haloperidol and risperidoneon plasma and erythrocyte magnesium and on plasmatic levels of zinc, calcium and copper on hospitalized 56 patients diagnosed with paranoid schizophrenia (DSM IV).


RESULTS
Our data indicate a decrease of erythrocyte magnesium levels in schizophrenic patients (4.82 +/- 3.1 mg/L vs. 59.2 +/- 1.1 mg/L in control group, p < 0.01). The plasma level of magnesium was unchanged (18.9 +/- 2.17 mg/L in schizophrenic patients vs. 18.26 +/- 1.9 mg/L in control group).


CONCLUSIONS
We consider plasma Cu(2+)/erythrocyte Mg(2+) and plasma Cu(2+)/Zn(2+) ratio two important biological markers of the acute paranoid schizophrenia.
Department of Pharmacology, University of Medicine and Pharmacy, Gr. T. Popa Iaśi, Str. Universită'tii nr. 16, Iaśi 700115, Romania. mnechif@iasi.mednet.ro
Mihai
M
Nechifor
C
C
Vaideanu
I
I
Palamaru
C
C
Borza
I
I
Mindreci
D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D003300:Copper / Q000097:blood; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D006220:Haloperidol; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018967:Risperidone; D012563:Schizophrenia, Paranoid / Q000097:blood* / Q000188:drug therapy*; D013053:Spectrophotometry; D015032:Zinc / Q000097:blood
D014150:Antipsychotic Agents; D015415:Biomarkers; D003300:Copper; D008274:Magnesium; D015032:Zinc; D006220:Haloperidol; D018967:Risperidone; D002118:Calcium