NMR spectroscopy of inclusion complex of D-(-)-chloramphenicol with beta-cyclodextrin in aqueous solution.
(1)HNMR spectroscopic study in D(2)O of mixtures of D-(-)-chloramphenicol (guest), present in two tautomeric forms in solution, and beta-cyclodextrin (host) revealed the formation of 1:1 inclusion complex in which aromatic ring of the guest is tightly held by the host cavity. There seems no discrimination between the aromatic rings of two tautomers by the host.
Department of Chemistry, Aligarh Muslim University, Aligarh-202002 UP, India. smashhoodali@yahoo.com
Syed Mashhood
SM
Ali
Fahmeena
F
Asmat
Arti
A
Maheshwari
D002701:Chloramphenicol / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D047392:beta-Cyclodextrins / Q000737:chemistry*
D047392:beta-Cyclodextrins; D002701:Chloramphenicol; C031215:betadex