Ciprofloxacin-induced renal insufficiency in cystic fibrosis.
Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly. We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy. The incidence of this adverse effect in children and young adults who have cystic fibrosis is unknown. Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.
Moffett
Brady S
BS
Department of Pharmacy, The Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Park 316, Baltimore, MD 21287, USA.
Rosenstein
Beryl J
BJ
Mogayzel
Peter J
PJ
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001806:Blood Urea Nitrogen; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D003550:Cystic Fibrosis / Q000188:drug therapy*; D005260:Female; D006801:Humans
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D003404:Creatinine