Detecting and managing patients with type 2 diabetic kidney disease: proteinuria and cardiovascular disease.
BACKGROUND
The increasing prevalence of type 2 diabetes (T2DM) places more patients at risk for developing chronic kidney disease (CKD) or cardiovascular (CV) events. Effective therapy for CKD or CV disease (CVD) requires a method of identifying affected patients and monitoring the effectiveness of therapy.


METHODS
We tested the predictive value of proteinuria for identifying patients at risk for progressive CDK and CVD, and monitoring treatment was determined using RENAAL study results.


RESULTS
Baseline proteinuria identified patients at risk for progressive CKD and CVD. Suppression of proteinuria was associated with decreased likelihood of CKD or CVD.


CONCLUSIONS
Proteinuria identifies the risk of CKD and CVD, and can be used to monitor the effectiveness of therapy.
Mitch
William E
WE
University of Texas Medical Branch, Galveston, Texas, USA. wmitch@utmb.edu
Shahinfar
Shahnaz
S
Dickson
Tania Z
TZ
de Zeeuw
Dick
D
Zhang
Zhongxin
Z
D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D011237:Predictive Value of Tests; D011507:Proteinuria / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D012307:Risk Factors