Relative flexibility of DNA and RNA: a molecular dynamics study.
State of the art molecular dynamics simulations are used to study the structure, dynamics, molecular interaction properties and flexibility of DNA and RNA duplexes in aqueous solution. Special attention is paid to the deformability of both types of structures, revisiting concepts on the relative flexibility of DNA and RNA duplexes. Our simulations strongly suggest that the concepts of flexibility, rigidity and deformability are much more complex than usually believed, and that it is not always true that DNA is more flexible than RNA.
Noy
Agnes
A
Molecular Modeling and Bioinformatics Unit, Institut de Recerca Biomèdica, Parc Científic de Barcelona, Josep Samitier 1-5, Barcelona 08028, Spain.
Pérez
Alberto
A
Lankas
Filip
F
Javier Luque
F
F
Orozco
Modesto
M
D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D018583:Pliability; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D013816:Thermodynamics
D012313:RNA; D004247:DNA