Clinical value of serum squamous cell carcinoma antigen in the management of sinonasal inverted papilloma.
BACKGROUND
Although sinonasal inverted papilloma (IP) is a rare benign tumor, it has a tendency to recur and is sometimes associated with squamous cell carcinoma (SCC). Therefore, postoperative long-term follow-up of these patients is recommended. We previously reported that serum SCC antigen might be a useful tumor marker for sinonasal IP. In this study, we investigated whether serum SCC antigen level has a correlation with disease status and is useful in the early detection of recurrent disease.


METHODS
Blood samples for the analysis of serum SCC antigen were taken from 28 IP patients before and after surgical treatment.


RESULTS
Twenty-five (89%) of 28 cases showed evaluated serum SCC antigen levels above the upper limit. This marker level decreased in all cases after surgical resection. Four of these patients had a recurrence. None of the patients with recurrent tumor showed symptoms at the time of detection of their recurrent tumor, and recurrence was discovered from elevated levels of SCC antigen.


CONCLUSIONS
Serum SCC antigen level has a correlation with disease status of IP and has a potential to serve as a useful tool for monitoring the course of disease. SCC antigen is a reliable tumor marker in the management of sinonasal IPs.
Yasumatsu
Ryuji
R
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. ryuji.yasumatsu@childrens.harvard.edu
Nakashima
Torahiko
T
Masuda
Muneyuki
M
Kuratomi
Yuichiro
Y
Shiratsuchi
Hideki
H
Hirakawa
Naoya
N
Tomita
Kichinobu
K
Yamamoto
Tomoya
T
Komune
Shizuo
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018308:Papilloma, Inverted / Q000097:blood* / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000097:blood* / Q000601:surgery; D012016:Reference Values
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor