[Effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats].
OBJECTIVE
To investigate the effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats.


METHODS
Forty-seven Wistar rats were randomly allocated into six groups: sham-operated (sham), ovarietomized (ovx), ovarietomized supplied with diethyl stilbestrol (E, 20 microg/kg BW) or genistetin (25, 50, 100 mg/kg BW). After the rats had been fed for three months, the bone mineral density and biomechanical properties and histomorphometric parameters of the rats was analysed.


RESULTS
The trabecular bone volume and the mean trabecular plate density and bone density of ovariectomized rats were significantly decreased, while the mean trabecular plate space increased compared with sham animals. After three months supplementation to ovariectomized rats, trabecular bone volume and mean trabecular plate density increased.


CONCLUSIONS
Genistein can reduced bone loss on ovariecromized rats.
Department of Nutrition, General Hospital of Chinese PLA, Beijing 100853, China.
Yuehong
Y
Zhang
Hong
H
Jin
Zhiqin
Z
Xu
Wenkao
W
Nan
Xianyuan
X
Wang
Changyong
C
Xue
Lanxing
L
Gao
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D001862:Bone Resorption / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D005260:Female; D019833:Genistein / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D006131:Growth Inhibitors; D019833:Genistein