Evaluation of analgesic, antipyretic activity and toxicity study of Bryonia laciniosa in mice and rats.
Analgesic, antipyretic activity and toxicity study of the leaves of Bryonia laciniosa Linn. (Family: Cucurbitaceae) was evaluated in the standard animal models. The methanol extract of Bryonia laciniosa (MEBL) was evaluated by hot plate and acetic acid-induced writhing methods to assess analgesic activity. The antipyretic activity of the extract was also evaluated by normal body temperature and yeast-induced hyperpyrexia. The extract showed significant analgesic and antipyretic activity. The MEBL was further evaluated for toxicity at the doses of 125 and 250 mg/kg administered orally for 14 days in rats. At the end of experiments, the blood, liver function and kidney metabolism were observed. The hematological profile and different biochemical parameters such as SGOT, SGPT and ALP were estimated. The present study revealed that MEBL exhibited significant analgesic and antipyretic activity in the tested experimental animal models. The toxicity study indicates that the extract is not toxic at the tested doses.
Natural Products Research Laboratory, J. K. K. Nataraja College of Pharmacy, Tamilnadu, India. sivaecp@yahoo.com
T
T
Sivakumar
P
P
Perumal
R Sambath
RS
Kumar
M L M
ML
Vamsi
P
P
Gomathi
U K
UK
Mazumder
M
M
Gupta
D000410:Alanine Transaminase / Q000032:analysis; D019883:Alkyl and Aryl Transferases / Q000032:analysis; D000700:Analgesics / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D029772:Bryonia; D004305:Dose-Response Relationship, Drug; D005260:Female; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008297:Male; D008305:Malignant Hyperthermia / Q000517:prevention & control; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D017855:Transferases (Other Substituted Phosphate Groups) / Q000032:analysis
D000700:Analgesics; D010936:Plant Extracts; D019883:Alkyl and Aryl Transferases; C112459:geranylpyrophosphate olivetolate geranyltransferase; D000410:Alanine Transaminase; D017855:Transferases (Other Substituted Phosphate Groups); C106504:UDP-GlcNAc-undecaprenyl phosphate N-acetylglucosaminyl 1-phosphate transferase