Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow.
OBJECTIVE
The study aims were to determine the role of inflammation in the pathogenesis of increased intracranial pressure (ICP) in patients with acute liver failure (ALF) and its interplay with cerebral blood flow (CBF) and ammonia.


METHODS
Twenty-one patients with ALF were studied from the time they were ventilated for grade 4 encephalopathy until receiving specific treatment for increased ICP. Depending upon the ICP, the patients were divided into two groups; those that required specific treatment (ICP>20 mmHg, group 1: n=8, ICP: 32 (28-54) mmHg); and those that did not (ICP< or =20 mmHg, group 2: n=13, ICP: 15 (10-20) mmHg).


RESULTS
Inflammatory markers, arterial ammonia and CBF were significantly higher in the group 1 patients. TNFalpha levels correlated with CBF (r=0.80). Four patients from group 2 developed surges of increased ICP (32 (15-112) hours from enrolment). These were associated increases in markers of inflammation and TNFalpha, and an increase in CBF. There was no change in these inflammatory markers, CBF or ICP in the other 9 group 2 patients.


CONCLUSIONS
The results of this study suggest that inflammation plays an important synergistic role in the pathogenesis of increased ICP possibly through its effects on CBF.
Jalan
Rajiv
R
Liver Failure Group, Institute of Hepatology, Royal Free and University College London Medical School and University College London Hospitals, 69-75 Chenies Mews, London WC1E 6HX, UK. r.jalan@ucl.ac.uk
Olde Damink
Steven W M
SW
Hayes
Peter C
PC
Deutz
Nicolaas E P
NE
Lee
Alistair
A
D000328:Adult; D000641:Ammonia / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000378:metabolism*; D002319:Cardiovascular System / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications*; D019586:Intracranial Hypertension / Q000209:etiology*; D007427:Intracranial Pressure; D017114:Liver Failure, Acute / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D008297:Male
D015415:Biomarkers; D000641:Ammonia