Monoamine oxidase inhibitors, their structural analogues, and neuroprotection.
Monoamine oxidase (MAO) inhibitors have been used for many years in the treatment of psychiatric and neurological disorders. More recently, some of these drugs and their analogues have been shown to have neuroprotective and neurorescue effects in several models of neurologic insult, including in vitro and in vivo models of cerebral ischemia. This review will discuss current evidence regarding these aspects of l-deprenyl, tranylcypromine, phenelzine, and some structurally related drugs.
Sowa
Bernard N
BN
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada T6G 2R7.
Holt
Andrew
A
Todd
Kathryn G
KG
Baker
Glen B
GB
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000627:therapeutic use*
D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents