[Envelope capture by retroviruses].
Retroelement transposition is a major source of diversity in genome evolution. Among the retrotransposable elements, the retroviruses are distinct in that their "transposition" extends from their initial host cells to neighboring cells and organisms. A determining step in the conversion of a retrotransposable element into an infectious retrovirus is the acquisition of an envelope glycoprotein, designated Env. Here, we review some examples of envelope "capture" by mammal retroviruses and provide evidence for such a mechanism by HTLV. This phenomenon may explain the notable conservation of env genes observed between phylogenetically distant retroviruses. Elucidation of these recombination processes should help to clarify retroviral phylogeny, better understand retroviral pathogenesis, and may lead to the identification of new retroelements.
Institut de Génétique moléculaire de Montpellier (IGMM), CNRS-UMR5535, IFR122 et Université de Montpellier II, 1919, route de Mende, 34293 Montpellier 05, France. kim@mskcc.org
Felix J
FJ
Kim
Nicolas
N
Manel
Jean-Luc
JL
Battini
Marc
M
Sitbon
D000818:Animals; D015752:Genes, env; D016679:Genome, Viral; D006801:Humans; D018626:Retroelements / Q000235:genetics; D012190:Retroviridae / Q000235:genetics*; D012192:Retroviridae Infections / Q000503:physiopathology*; D014759:Viral Envelope Proteins / Q000235:genetics*
D018626:Retroelements; D014759:Viral Envelope Proteins