Plasma cGMP and large artery remodeling in asymptomatic men.
cGMP regulates vascular smooth muscle tone and arterial wall response to proliferative signals. We determined plasma cGMP and carotid artery intima-media thickness (IMT) and diameter in 84 asymptomatic men submitted to investigation of their cardiovascular risk profiles. Plasma cGMP was positively associated with IMT (P<0.01) and diameter (P<0.05), independently of coexisting risk factors. These associations were reinforced in the subgroup of subjects with high-sensitivity C-reactive protein level or multiple atherosclerotic plaques. A positive relationship existed between diameter and IMT (P<0.01) and disappeared after cGMP adjustment. This suggests a link between cGMP pathway and arterial wall geometry that is revealed by vascular injury conditions and may participate in early large artery remodeling.
Devynck
Marie-Aude
MA
Centre de Médecine Préventive Cardiovasculaire, UNR-CNRS 7131, Hôpital Broussais, Assistance Publique-Hôpitaux de Paris, Université Paris 5, France.
Simon
Alain
A
Pernollet
Marie-Gabrielle
MG
Chironi
Gilles
G
Gariepy
Jérôme
J
Rendu
Francine
F
Levenson
Jaime
J
D001161:Arteriosclerosis / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000378:metabolism; D002339:Carotid Arteries / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology; D006152:Cyclic GMP / Q000097:blood* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D017539:Tunica Intima / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D014463:Ultrasonography
D002097:C-Reactive Protein; D006152:Cyclic GMP