[ATM and telomere instability].
Accumulation of DNA damage has been associated with the onset of senescence and the predisposition to cancer. The gene responsible for ataxia telangiectasia (A-T) is ATM (Ataxia-telangiectasia mutant), a master controller of cellular pathways and networks, orchestrating the response to a specific type of DNA damage, i.e., the double strand break. It has now been demonstrated that mutations in ATM lead to defective telomere maintenance in mammalian cells. This review will focus on its roles in telomere metabolism and how ATM and telomeres serve as controllers of cellular responses to DNA damage.
Wang
Hong-Mei
HM
Department of Forensic Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Xia
Yun-Fei
YF
Wu
Xin-Yao
XY
D001260:Ataxia Telangiectasia / Q000235:genetics*; D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D043171:Chromosomal Instability; D004249:DNA Damage; D004268:DNA-Binding Proteins; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction; D019098:Telomerase / Q000378:metabolism; D016615:Telomere; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases; D019098:Telomerase