[Effects of norepinephrine on the therapeutic effect of nitric oxide inhalation in the treatment of acute respiratory distress syndrome in goat].
OBJECTIVE
To observe effects of norepinephrine (NE) on the therapeutic effects of nitric oxide (NO) inhalation in goats with endotoxin-induced acute respiratory distress syndrome (ARDS).


METHODS
A model of septic ARDS was reproduced by an intravenous infusion of low dose endotoxin in six goats, and then these animals were treated with 40 x 10(-6) NO inhalation. After 30 minutes, intravenous infusion of NE in dose of 0.5 microg x kg(-1) x h(-1) was given. The dynamic changes in gas exchange and hemodynamics were measured with the aid of Swan-Ganz catheter and arterial blood gas analysis before and after the onset of ARDS, 30 minutes after NO inhalation and administration of NE.


RESULTS
Inhalation of NO rapidly reduced mean pulmonary arterial pressure (MPAP), increased PaO(2), decreased alveolar-arterial partial pressure of oxygen difference (P (A-a) O(2)) and intrapulmonary shunt fraction (Qs/Qt) in septic ARDS goats. These changes were more pronounced when NE was given compared with NO inhalation alone. The combination of NO inhalation and NE infusion resulted in an increase in mean arterial pressure.


CONCLUSIONS
Norepinephrine enhances the beneficial effect of nitric oxide inhalation on lung gas exchange in goats with endotoxin induced acute respiratory distress syndrome.
The First Affiliated Hospital of Nanjing Medicial University, Nanjing 210029, Jiangsu, China.
Shao-Hua
SH
Liu
Xin-Rong
XR
Xu
Ji
J
Xu
Xiang-Rong
XR
Zuo
Ping-Ping
PP
Qin
D000818:Animals; D004195:Disease Models, Animal; D004357:Drug Synergism; D006041:Goats; D006439:Hemodynamics / Q000187:drug effects; D009569:Nitric Oxide / Q000627:therapeutic use*; D009638:Norepinephrine / Q000627:therapeutic use*; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000503:physiopathology
D009569:Nitric Oxide; D009638:Norepinephrine