Ezrin gene, coding for a membrane-cytoskeleton linker protein, is regionally expressed in the developing mouse neuroepithelium.
Ezrin is a member of the Ezrin, Radixin, Moesin (ERM) proteins family that are proposed to act as linkers between the cytoskeleton and plasma membrane. Ezrin regulates cell-cell and cell-matrix interactions playing a role in the regulation of cellular adhesion, movement and morphology in epithelia. Alterations in the expression of Ezrin and other members of ERM family have also been observed in brain tumours. Here we report the expression pattern of Ezrin during mouse neural development, from early stages to postnatal stages. In young and middle gestation embryos, Ezrin is expressed in the roof plate of the neural tube, in the presumptive domain of the choroidal plexus, and in some precise domains of ventricular epithelium. These domains are distributed in basal and alar neuroepithelial regions, some of them in relation to the expression of cadherins. At later gestation and postnatal stages, Ezrin expression is maintained on the mature choroidal plexus and is weakly detected in the proliferative regions of the mature brain.
Instituto de Neurociencias, CSIC-UMH, Campus de San Juan, Apdo correos 18, 03550 Alicante, Spain.
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Gimeno
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Corradi
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Cobos
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Consalez
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Martinez
D000818:Animals; D001921:Brain / Q000196:embryology*; D002462:Cell Membrane / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D016518:Neurofibromatosis 2 / Q000378:metabolism; D010750:Phosphoproteins / Q000096:biosynthesis* / Q000502:physiology*; D017434:Protein Structure, Tertiary; D013997:Time Factors; D014018:Tissue Distribution; D000099149:Ezrin
D003598:Cytoskeletal Proteins; D010750:Phosphoproteins; D000099149:Ezrin