Ena/VASP family: new partners, bigger enigma.
Linking external signals to remodeling of the cytoskeleton is essential to multiple processes during animal development and physiology. Two new studies have uncovered a new family of proteins that can regulate actin dynamics both locally at the membrane interface and globally throughout the cell.
Bailly
Maryse
M
Division of Cell Biology, Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, United Kingdom.
D000199:Actins / Q000378:metabolism; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001665:Binding Sites; D015815:Cell Adhesion Molecules / Q000737:chemistry* / Q000378:metabolism; D003285:Contractile Proteins / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D008840:Microfilament Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000737:chemistry* / Q000378:metabolism; D051304:Profilins; D011392:Proline / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011554:Pseudopodia / Q000378:metabolism; D015398:Signal Transduction; D014615:Vaccinia / Q000378:metabolism; D020827:rap1 GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D000098662:Vasodilator-Stimulated Phosphoprotein
D000199:Actins; D015815:Cell Adhesion Molecules; D003285:Contractile Proteins; C102177:Evl protein, mouse; D016023:Integrins; D008024:Ligands; D008840:Microfilament Proteins; D010750:Phosphoproteins; D051304:Profilins; D000098662:Vasodilator-Stimulated Phosphoprotein; D011392:Proline; D020558:GTP Phosphohydrolases; D020827:rap1 GTP-Binding Proteins