Fatal staphylococcal sepsis in Crohn's disease after infliximab.
We report a case of a 40-year-old woman who had received infliximab for perianal Crohn's disease. After six infusions of infliximab, the patient developed staphylococcal pneumonia resulting in fatal adult respiratory distress syndrome. The case is discussed in the context of the toxicity profile of infliximab.
Herrlinger
Klaus R
KR
Department of Internal Medicine, Robert-Bosch-Hospital, Stuttgart, Germany.
Borutta
Annette
A
Meinhardt
Gabriel
G
Stange
Eduard F
EF
Fellermann
Klaus
K
D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D000069285:Infliximab; D018410:Pneumonia, Bacterial / Q000139:chemically induced*; D012003:Rectal Fistula / Q000209:etiology / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000139:chemically induced; D018805:Sepsis / Q000139:chemically induced*; D013203:Staphylococcal Infections / Q000139:chemically induced*; D014409:Tumor Necrosis Factor-alpha
D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab