title: Elucidation of structure-activity relationships for 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones.
abstract: 1,4-Naphthoquinones have already been recognized to possess a wide range of biological activities. We have developed quantitative structure activity relationships (QSAR) for different series of 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones to understand the chemical-biological interaction governing antiproliferative/cytotoxic activities against L1210 cells. QSAR results have shown that these activities of 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones depend largely on their hydrophobicity.
authors.affiliation: Department of Chemistry, Pomona College, Claremont, CA 91711, USA. rverma@pomona.edu
authors.forename: Rajeshwar P
authors.initials: RP
authors.lastname: Verma
authors.forename: Corwin
authors.initials: C
authors.lastname: Hansch
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D021281:Quantitative Structure-Activity Relationship; D013329:Structure-Activity Relationship
chemical_list: D009285:Naphthoquinones