Scintigraphic assessment of slow transit constipation with special reference to right- or left-sided colonic delay.
OBJECTIVE
Subtotal colectomy and ileorectal anastomosis for slow transit constipation has several side-effects. The motor abnormality in some patients may be segmental which could motivate a limited resection of the colon. Therefore a diagnostic tool to identify a segmental colonic motor dysfunction is needed. The aim of this study was to evaluate a scintigraphic method to assess colonic transit with special reference to right- or left-sided delay.


METHODS
Twenty-three constipated patients (19 women, mean age 50 years) with slow colonic transit on radio-opaque marker studies and 13 healthy individuals (11 women, mean age 46 years) were studied. All subjects were examined with oral (111)Indium-DTPA scintigraphy. The scintigraphic results for patients and controls were presented as geometric centre of radioactivity and percent activity over time in the right, the left and the recto-sigmoid colon. The inter-observer variation in the interpretation of the scans was also evaluated.


RESULTS
There was no difference in transit time between the groups of patients and controls in the right colon whereas the patients had a significant delay in the left colon (P < 0.05). Two patients had a marked delay in the right colon followed by relatively rapid transit in the left colon. The inter-observer correlation was good comparing the right, the left and the recto-sigmoid colon (r = 0.58-0.98, P < 0.01-0.001).


CONCLUSIONS
The results indicate that colonic scintigraphy with oral (111)Indium-DTPA may help to select patients for a left or, in a few cases, a right hemicolectomy for slow transit constipation.
Lundin
E
E
Department of Nuclear Medicine, University Hospital, SE-751 85 Uppsala, Sweden. erik.lundin@kirurgi.uas.lul.se
Karlbom
U
U
Westlin
J E
JE
Kairemo
K
K
Jung
B
B
Husin
S
S
Påhlman
L
L
Graf
W
W
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003106:Colon / Q000502:physiology; D003248:Constipation / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology*; D049691:History, Medieval; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008365:Manometry; D008875:Middle Aged; D015588:Observer Variation; D011336:Probability; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013997:Time Factors
D007205:Indium Radioisotopes