[Air embolus as a complication of a haemoperfusion catheter removal after iatrogenic intoxication with doxorubicin--a case report].
The case of a 67-year-old patient, treated for melanoma, who was given a toxic dose of doxorubicin (600 mg/m2), was described. The haemoperfusion was performed a short time after intoxication. No toxic effects were seen during the observation for three weeks. The catheter was removed from the sitting patient by an oncologist. The patient abruptly lost consciousness, there were also cyanosis, loss of muscle tone and apnea. The reanimation was unsuccessful. The air embolism was probably the cause of death. The diagnosis was confirmed by the sudden attack, wide duct after the removal of catheter, sitting position of the patient and the presence of foramen ovale found during autopsy.


CONCLUSIONS
Cannulation as well as decannulation of the central vessels should be performed by experienced doctors. Decannulation should always be done in the Trendelenburg position.
Chodorowski
Zygmunt
Z
I Klinika Chorób Wewnetrznych i Ostrych Zatruć, Akademii Medycznej w Gdańsku. jsanand@amedec.amg.gda.pl
Sein Anand
Jacek
J
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000506:poisoning; D001344:Autopsy; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D004317:Doxorubicin / Q000506:poisoning; D004618:Embolism, Air / Q000175:diagnosis* / Q000209:etiology*; D017809:Fatal Outcome; D006464:Hemoperfusion / Q000295:instrumentation*; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D011041:Poisoning / Q000628:therapy; D011187:Posture
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin