title: Tracheo-bronchitis associated with Crohn's disease improved on inhaled corticotherapy.
abstract: We report a case of tracheo-bronchitis in Crohn's disease. A 23-year-old Japanese woman who had been diagnosed with Crohn's disease three years previously was hospitalized. She had been suffering from dry cough for one month. Computed tomography of the chest revealed marked thickening of the tracheal wall. Bronchoscopy showed erythematous and edematous mucosa with diffuse whitish granular lesions in the trachea and bronchi. The bronchial biopsy specimens showed non-specific inflammatory infiltrates consisting of lymphocytes and plasma cells, and hyperplasia of bronchial glands. Inhaled corticotherapy, fluticasone propionate 800 microg/day, was effective for both the inflammatory mucosa and thickened tracheal wall.
authors.affiliation: Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kinebuchi
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Oohashi
authors.forename: Toshinori
authors.initials: T
authors.lastname: Takada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moriyama
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Yoshizawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Kobayashi
authors.forename: Eiichi
authors.initials: E
authors.lastname: Suzuki
authors.forename: Fumitake
authors.initials: F
authors.lastname: Gejyo
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001991:Bronchitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D001999:Bronchoscopy; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D000068298:Fluticasone; D006801:Humans; D014057:Tomography, X-Ray Computed; D014136:Tracheitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000068298:Fluticasone