Pamidronate treatment in acute vitamin D intoxication.
Management with glucocorticoid, high iv fluid saline intake, furosemide and calcitonin may not result in a favorable reduction of hypercalcemia and may cause several side effects in infants with acute vitamin D intoxication. The bisphosphonate pamidronate, a specific inhibitor of bone resorption through osteoclast mediation was successfully used in a 6-month old infant with acute vitamin D intoxication managed in the Pediatric Emergency and Intensive Care Unit, after an ineffective trial of hydration, furosemide, calcitonin and prednisolone. After a double infusion of pamidronate on two consecutive days (1 mg/kg/day), an early and safe correction of hypercalcemia/hypercalciuria was supplied. Pamidronate therapy may be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.
Gurkan
F
F
Department of Pediatrics, Pediatric Emergency Unit, Dicle University Medical School, Diyarbakir, Turkey. fuatgurkan@hotmail.com
Davutoglu
M
M
Bosnak
M
M
Ece
A
A
Dikici
B
B
Bilici
M
M
Haspolat
K
K
D000208:Acute Disease; D000284:Administration, Oral; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D000077268:Pamidronate; D014807:Vitamin D / Q000008:administration & dosage / Q000506:poisoning*
D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D014807:Vitamin D; D000077268:Pamidronate