[Laboratory assessment problems of the efficacy of acellular pertussis vaccines].
Although composition of acellular pertussis vaccines is better defined than whole-cell vaccines, differences in the formulation, content, and detoxification of pertussis vaccine antigens led to a unique character of each of differently produced acellular vaccine. Currently used methods for laboratory evaluation of whole-cell pertussis vaccine efficacy were found not suitable for acellular vaccines. There is a strong need to perform analysis and evaluation of the safety and efficacy profiles of acellular pertussis vaccines combined with other vaccine antigens (e.g. Hib) both before and after conjugation. Mechanisms of interactions seen after conjugation inducing weaker immunogenicity or efficacy are still poorly recognized.
Gzyl
Anna
A
Zakład Badania Surowic i Szczepionek Państwowego Zakładu Higieny, Warszawa.
D000917:Antibody Formation / Q000276:immunology*; D006801:Humans; D008828:Microbiological Techniques; D010567:Pertussis Vaccine / Q000276:immunology* / Q000592:standards*; D022282:Vaccines, Acellular / Q000276:immunology / Q000592:standards
D010567:Pertussis Vaccine; D022282:Vaccines, Acellular