title: [Familial dyskeratotic comedone].
abstract: BACKGROUND
  Familial dyskeratotic comedones is a rare affection of autosomal transmission and characterized by pseudo-comedone papules predominantly on the limbs. We report a new familial case characterized by its clinical and histological profile.
  
  
  METHODS
  A 6 year-old boy presented with a papular, pseudo-comedone eruption that had appeared shortly after birth and had progressively extended symmetrically to both legs. The child's father complained of a similar eruption since childhood. Histological examination of the papules revealed a pseudo-follicular invagination, obstructed by keratin and associated with areas of focal dyskeratosis. Treatment with local retinoids was ineffective.
  
  
  CONCLUSIONS
  Since it is often asymptomatic, the prevalence of dyskeratosis comedones is probably underestimated. A review of the literature on the preceding observations is presented. The dermatites that would represent differential diagnoses because of the presence of comedone-like lesions and/or histological dyskeratosis are discussed.
authors.affiliation: Service de Dermatologie, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France. carine.michot@wanadoo.fr
authors.forename: C
authors.initials: C
authors.lastname: Michot
authors.forename: J-J
authors.initials: JJ
authors.lastname: Guilhou
authors.forename: D
authors.initials: D
authors.lastname: Bessis
mesh_terms: D002648:Child; D007644:Darier Disease / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007866:Leg / Q000473:pathology; D008297:Male; D010375:Pedigree; D012176:Retinoids / Q000627:therapeutic use; D012873:Skin Diseases, Genetic / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
chemical_list: D012176:Retinoids