title: Marked elevation of soluble fas ligand and cytokine secretion after splenectomy in aggressive natural killer cell leukemia/lymphoma.
abstract: We report a case of Epstein-Barr virus-associated aggressive natural killer cell leukemia/lymphoma with giant splenomegaly in which splenectomy resulted in progression of apoptosis and hemophagocytosis. The serum level of ferritin, triglycerides, interferon-gamma (IFN-gamma), interleukin 10 (IL-10), and soluble Fas ligand (sFasL) increased markedly, and liver damage progressed after splenectomy. The number of apoptotic cells in peripheral blood smears increased following splenectomy. In the present case, splenectomy caused disruption of the cytokine network, resulting in apoptosis of blood cells and hepatocytes, as well as phagocytosis.
authors.affiliation: Department of Pediatrics, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Kaizu
authors.forename: Miho
authors.initials: M
authors.lastname: Maeda
authors.forename: Takuya
authors.initials: T
authors.lastname: Ohkawa
authors.forename: Mari
authors.initials: M
authors.lastname: Hayashida
authors.forename: Seiko
authors.initials: S
authors.lastname: Nakajima
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sugisaki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Fukunaga
mesh_terms: D000293:Adolescent; D017209:Apoptosis; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D053222:Fas Ligand Protein; D017809:Fatal Outcome; D005293:Ferritins / Q000097:blood; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D007694:Killer Cells, Natural / Q000166:cytology*; D007938:Leukemia / Q000097:blood* / Q000628:therapy; D008099:Liver / Q000293:injuries; D008223:Lymphoma / Q000097:blood* / Q000628:therapy; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D010587:Phagocytosis; D013156:Splenectomy; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D016207:Cytokines; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D014280:Triglycerides; D016753:Interleukin-10; D007371:Interferon-gamma; D005293:Ferritins