Glomerular filtration rate: assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney.
OBJECTIVE
To describe the use of MRI and a cortical-compartment model to measure the glomerular filtration rate (GFR), and compare the results with those obtained with the Patlak-Rutland model.


METHODS
Dynamic MRI of rabbit kidneys was performed during and after injection of gadoterate dimeglumine. The enhancement curves in the aorta and the kidney were analyzed with the cortical-compartment and Patlak-Rutland models to assess the GFR.


RESULTS
A substantial correlation was observed between the GFR measured with MRI using the cortical-compartment model and the plasma clearance of 51Cr-EDTA (r=0.821, P=0.004). No significant correlation was observed between the 51Cr-EDTA clearance (r=0.628, P=0.052) and the GFR obtained with the Patlak-Rutland model in regions of interest (ROIs) encompassing the renal cortex and medulla. A Bland and Altman analysis showed that GFR(cortical) (compartment) agreed better with the 51Cr-EDTA clearance compared to GFR(Patlak) when ROIs were limited to the cortex. However, the GFR values obtained by MRI were lower than the plasma clearance of 51Cr-EDTA.


CONCLUSIONS
MRI with a cortical-compartment model provides more accurate assessments of glomerular filtration than the Patlak-Rutland model.
Annet
Laurence
L
Department of Radiology, Université Catholique de Louvain, Cliniques Universitaires St.-Luc, Brussels, Belgium. laurence.annet@clin.ucl.ac.be
Hermoye
Laurent
L
Peeters
Frank
F
Jamar
François
F
Dehoux
Jean-Paul
JP
Van Beers
Bernard E
BE
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D005919:Glomerular Filtration Rate / Q000502:physiology*; D020896:Hypovolemia / Q000503:physiopathology; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007668:Kidney / Q000033:anatomy & histology* / Q000098:blood supply / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage*; D023421:Models, Animal; D009942:Organometallic Compounds / Q000008:administration & dosage*; D011817:Rabbits; D015203:Reproducibility of Results; D013997:Time Factors
D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine