Microwave thermotherapy of prostatic enlargement--analysis of radiometric thermometry using a hybrid bio-heat equation.
The radiometric temperature measurement included in a commercial device for transurethral microwave thermotherapy (TUMT) of the prostate was investigated utilizing both phantom experiments and computer simulations. Two finite element (FE) models were developed. One is in part based on the experimental results, and serves as a complement to the experiments, while the other describes a perfused tissue situation for which the hybrid bio-heat equation was used to model the thermal effects of blood perfusion. The aim of the study was to investigate how the radiometric thermometer is affected by the temperature close to the antenna, and to analyze the relation between blood perfusion, temperature distribution and radiometric temperature measurement. It was found that the radiometric temperature was affected to a greater extent by the temperature very close to the antenna, in contrast to what has been expected in previous studies. The blood perfusion was found to mainly affect the temperature distribution outside the maximum temperature (located 2-3 mm outside the cooled catheter). Thus, the relation between the radiometric temperature and the temperature in the treated area is relatively weak.
Wren
Joakim
J
Department of Mechanical Engineering, Linköpings Universitet, SE-581 83 Linköping, Sweden. joawr@ikp.liu.se
D016477:Artifacts; D001833:Body Temperature Regulation / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008954:Models, Biological; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013813:Therapy, Computer-Assisted / Q000379:methods; D013817:Thermography / Q000295:instrumentation / Q000379:methods*; D020728:Transurethral Resection of Prostate / Q000379:methods*; D016896:Treatment Outcome