title: Synthesis, characterization and antimicrobial activity of 1,5-bis[2-(hydroximino)-1-methyl-3-oxo-butane-1,1-diyl]thiocarbonohydrazide and 1,5-bis[2-(hydroximino) -3-oxo-1-phenyl-butane-1,1-diyl]thiocarbonohydrazide.
abstract: 1,5-Bis[2-(hydroximino)-1-methyl-3-oxo-butane-1,1-diyl]thiocarbonohydrazide [IV] and 1,5-bis[2-(hydroximino)-3-oxo-1-phenyl-butane-1,1-diyl]thiocarbonohydrazide [V] were synthesized by the reaction of thiocarbonohydrazide [I] with either 3-(hydroximino)-pentane-2,4-dione [II] or 2-(hydroximino)-1-phenyl-butane-1,3-dione [III] in a 1:2 molar proportion, respectively. Compounds [IV] and [V] were characterized by elemental analyses, IR and PMR spectroscopic studies. These newly synthesized compounds have been screened or their antimicrobial activity against S. aureus, S. typhi. C. albicans, T. mentagrophytes, T. rubrum and M. tuberculosis.
authors.affiliation: Department of Chemistry, The Institute of Science, Mumbai, India.
authors.forename: Meenakshi V
authors.initials: MV
authors.lastname: Patil
authors.forename: Sheela P
authors.initials: SP
authors.lastname: Malve
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D006834:Hydrazines / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data
chemical_list: D000900:Anti-Bacterial Agents; D006834:Hydrazines; C011368:thiocarbohydrazide