title: Enzyme inhibiting lignans from Vitex negundo.
abstract: Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.
authors.affiliation: International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.lastname: Azhar-Ul-Haq
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.forename: Sher Bahadar
authors.initials: SB
authors.lastname: Khan
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmed
authors.forename: Zaheer
authors.initials: Z
authors.lastname: Ahmed
authors.forename: Sarfraz Ahmad
authors.initials: SA
authors.lastname: Nawaz
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots; D020950:Vitex
chemical_list: D002800:Cholinesterase Inhibitors; D017705:Lignans; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase; D002091:Butyrylcholinesterase