Update on childhood neutropenia: molecular and clinical advances.
Congenital and inherited disorders are important differential diagnoses of neutropenia, particularly in neonates and children, although acquired causes are more common. This article focuses on recent advances in understanding the cellular and molecular defects in inherited neutropenias as well as issues that are related to clinical presentation, diagnosis, and complications.
Dror
Yigal
Y
Division of Hematology/Oncology, The Hospital for Sick Children and The University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada. yigal.dror@sickkids.ca
Sung
Lillian
L
D002648:Child; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D009503:Neutropenia / Q000145:classification / Q000235:genetics* / Q000628:therapy*