title: Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells.
abstract: A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E(2) production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.
authors.affiliation: College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Park
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Min
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Ahn
authors.forename: Cheol-Man
authors.initials: CM
authors.lastname: Bae
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Pyee
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000818:Animals; D002460:Cell Line; D015232:Dinoprostone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000094162:Phytoalexins
chemical_list: D015232:Dinoprostone; D008070:Lipopolysaccharides; D013267:Stilbenes; C049032:pinosylvin; D000094162:Phytoalexins