title: Synthesis and antihyperglycemic activity profiles of novel thiazolidinedione derivatives.
abstract: A number of thiazolidine-2,4-diones derivatives having carboxylic ester appendage at N-3 were synthesized and their antihyperglycemic activity was evaluated. Many of these derivatives as well as their corresponding carboxylic acid showed significant improvement on post-prandial hyperglycemia in normal rats, in contrast to their poor agonist activity at PPARgamma.
authors.affiliation: Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Bashir A
authors.initials: BA
authors.lastname: Bhat
authors.forename: Shashikanth
authors.initials: S
authors.lastname: Ponnala
authors.forename: Devi Prasad
authors.initials: DP
authors.lastname: Sahu
authors.forename: Priti
authors.initials: P
authors.lastname: Tiwari
authors.forename: Brajendra K
authors.initials: BK
authors.lastname: Tripathi
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D047495:PPAR gamma / Q000378:metabolism; D051381:Rats; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D047495:PPAR gamma; D045162:Thiazolidinediones