title: The plasminogen activator system in young and lean women with polycystic ovary syndrome.
abstract: The purpose of the study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) levels and PAI-1 activity in young and lean women with PCOS and to compare with controls matched for age and weight. Thirty two women with PCOS and 25 weight and age-matched healthy controls participated in this study. Patients were evaluated clinically and by pelvic ultrasound and fasting blood samples were taken for hematological and biochemical tests. Fasting insulin, glucose, lipid profile, FSH, LH, PRL, testosterone, SHBG, 17-hydroxyprogesterone, androstenedione, PAI-1 antigen; PAI-1 activity, insulin sensitivity indices (HOMA and QUICKI) were measured. PAI-1 Ag and activity were significantly higher in PCOS women than healthy control group. PAI-1 levels were directly correlated with BMI, insulin levels and insulin sensitivity indices. PAI-1 activity was also correlated with insulin levels and insulin resistance. As a conclusion PAI-1 Ag levels and activity were increased in lean PCOS women and these were directly correlated with insulin resistance. The finding may contribute to evidence of increase risk of cardiovascular disease and anovulatory infertility in PCOS women.
authors.affiliation: Department of Endocrinology and Metabolism, Kocaeli University Hospital, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Tarkun
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Cantürk
authors.forename: Berrin C
authors.initials: BC
authors.lastname: Arslan
authors.forename: Erdem
authors.initials: E
authors.lastname: Türemen
authors.forename: Pinar
authors.initials: P
authors.lastname: Tarkun
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001835:Body Weight; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D007328:Insulin; D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1