[Clinical peculiarities of optic neuritis and alterations of local immune response in patients with multiple sclerosis].
Multiple sclerosis (MS) is a severe organic disease of the central nervous system (CNS) affecting mostly young people. Optic neuritis (ON) is one of the first manifestations of the disease in approximately 75% of cases. The autoimmune reactions to myelin antigens play a key role in ON pathogenesis of MS. The pro- and anti-inflammatory unbalance is the most important factor of the origin, development and stabilization of CNS changes. Presented are the data on alterations of the levels of pro- and anti-inflammatory cytokines TNF-alpha, IF-gamma and antibodies to MBP and anti DNA in patient's tears. The clinical peculiarities of ON in MS correlating with immunological alterations are established.
Naroev
V V
VV
Karlova
I Z
IZ
Boĭko
A N
AN
Zaĭtsev
O V
OV
Gusev
E I
EI
D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology*; D009902:Optic Neuritis / Q000209:etiology* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D014792:Visual Acuity / Q000502:physiology
D007074:Immunoglobulin G; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma