title: First- and midtrimester Down syndrome screening and detection.
abstract: Overall, Down syndrome detection capabilities have improved remarkably over the last 2 decades. Widely practiced first-trimester screening and less extensively elevated midtrimester urine screening promise even greater accuracy than was available a decade ago. Recently, the combination of first- and second-trimester screening has been reported to enhance discrimination of the Down syndrome fetus from normal cases. Although the advances are welcome, they present the significant prospect of multiple competitive algorithms with the risk of confusing patients, practitioners, and health care planners. The need for reasonable consensus has never been more pressing.
authors.affiliation: University of Cincinnati, Department of Obstetrics and Gynecology, 231 Albert Sabin Way ML0526, Cincinnati, OH 45267-0526, USA. bahadoro@ucmail.ac.edu
authors.forename: Ray O
authors.initials: RO
authors.lastname: Bahado-Singh
authors.forename: Sang-Joon
authors.initials: SJ
authors.lastname: Choi
authors.forename: Chih Chien
authors.initials: CC
authors.lastname: Cheng
mesh_terms: D015415:Biomarkers / Q000097:blood; D001699:Biometry; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods*; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers