title: Comparative study of enamel matrix derivative with or without GTR in the treatment of class II furcation lesions in dogs.
abstract: Chronic Class II furcation lesions were created in four dogs. After 21 days, group I remained as a control, group 2 was treated with membranes and enamel matrix derivative (EMD), and group 3 received EMD alone. Healing in group 1 was characterized by a long junctional epithelium and discrete bone formation; group 2 showed reduced bone formation; and group 3 showed significant bone regeneration (area of new bone = 67.36%+/-3.93%; distance from furcation roof to bone crest = 0.57+/-0.15 mm). The EMD led to significant regeneration of the furcation lesions, and the association with membranes was detrimental.
authors.affiliation: Department of Oral and Maxillofacial Surgery and Traumatology and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil.
authors.forename: Plinio Fo
authors.initials: PF
authors.lastname: Regazzini
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Novaes
authors.forename: Paulo T
authors.initials: PT
authors.lastname: de Oliveira
authors.forename: Daniela B
authors.initials: DB
authors.lastname: Palioto
authors.forename: Mário
authors.initials: M
authors.lastname: Taba
authors.forename: Sergio L S
authors.initials: SL
authors.lastname: de Souza
authors.forename: Márcio F M
authors.initials: MF
authors.lastname: Grisi
mesh_terms: D000818:Animals; D001641:Bicuspid / Q000473:pathology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D004285:Dogs; D004492:Edetic Acid / Q000627:therapeutic use; D004846:Epithelial Attachment / Q000473:pathology; D017823:Furcation Defects / Q000145:classification / Q000473:pathology / Q000601:surgery*; D048091:Guided Tissue Regeneration / Q000379:methods*; D008567:Membranes, Artificial; D010012:Osteogenesis / Q000502:physiology; D011138:Polytetrafluoroethylene; D013524:Surgical Flaps; D014945:Wound Healing / Q000502:physiology
chemical_list: D018786:Bone Substitutes; D002614:Chelating Agents; D003746:Dental Enamel Proteins; D008567:Membranes, Artificial; C109069:enamel matrix proteins; D011138:Polytetrafluoroethylene; D004492:Edetic Acid