[The effect of mometasone furoate on mucociliary clearance in patients with perennial allergic rhinitis].
OBJECTIVE
We investigated the effect of mometasone furoate on mucociliary clearance in patients with perennial allergic rhinitis.


METHODS
The study included 25 patients (16 females, 9 males; mean age 30 years; range 18 to 50 years) with perennial allergic rhinitis. Mometasone furoate (nasal spray) was administered at a dose of 2 puffs (100 microgr) to each nostril daily for a month. Mucociliary clearance was evaluated by the saccharin test before and after treatment.


RESULTS
The mean mucociliary clearance time was 6.89 +/- 0.64 minutes before the treatment and 7.18 +/- 0.54 minutes after the treatment. No significant delay in the mucociliary clearance was detected (p > 0.05). The mean mucociliary clearance time did not differ significantly between male and female patients (p > 0.05).


CONCLUSIONS
The results suggest that mometasone furoate do not affect mucociliary clearance in patients with perennial allergic rhinitis.
Pata
Yavuz Selim
YS
Mersin Universitesi, Tip Fakültesi Kulak Burun Boğaz Hastahiklari Anabilim Dali, Mersin. yavuzpata@mersin.edu.tr
Akbaş
Yücel
Y
Unal
Murat
M
Görür
Kemal
K
Ozcan
Cengiz
C
Vayisoğlu
Yusuf
Y
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068656:Mometasone Furoate; D009079:Mucociliary Clearance / Q000187:drug effects*; D009297:Nasal Mucosa / Q000187:drug effects; D011244:Pregnadienediols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D018926:Anti-Allergic Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate