title: [Assessment of a topical NSAIDs in the treatment of pain and inflammation. The example of Flector Plaster, a local bioadhesive plaster containing diclofenac epolamine].
abstract: ADVANTAGES AND INCONVENIENCIES OF TRANSDERMAL SYSTEMS: Regarding the advantages, one notes the reduction or even suppression of the gastro-intenstinal disorders related to the oral administration of non-steroidal anti-inflammatories (NSAIDs), the absence of first pass hepatic effect and the better control of the quantities administered of a strong acting drug. Regarding the inconveniencies, one should bear in mind the impossibility of administering or the diffusion of high doses of irritant or sensitizing molecules on the skin. A preparation for application on the skin must be both hydrophilic and lipophilic, with great solubility in water and affinity for the lipids, as is the case with diclofenac epolamine. FROM AN EXPERIMENTAL POINT OF VIEW: Diclofenac epolamine has demonstrated a strong anti-inflammatory effect in the rat or the rabbit, with transfer following repeated local applications, measurable concentrations in the plasma and adjacent tissues, excellent general tolerance and the safety of the plaster. VARIOUS CLINICAL TRIALS: Have shown that the Flector Plaster is well tolerated and effective in the treatment of epicondylitis, sprained ankles, minor sport-induced trauma and osteo-arthrosis of the knee.
authors.forename: Marie
authors.initials: M
authors.lastname: Solignac
mesh_terms: D000287:Administration, Topical; D000818:Animals; D016512:Ankle Injuries / Q000150:complications / Q000188:drug therapy; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use*; D001265:Athletic Injuries / Q000150:complications / Q000188:drug therapy; D004008:Diclofenac / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D010003:Osteoarthritis / Q000150:complications / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy*; D011817:Rabbits; D051381:Rats; D013180:Sprains and Strains
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C064142:diclofenac hydroxyethylpyrrolidine; D004008:Diclofenac