Long-term persistence of clonally expanded T cells in patients with polymyositis.
Polymyositis is a CD8(+) T-cell-mediated disease. T-cell clonal expansions are observed at disease onset, but little is known about their persistence over time. Qualitative and quantitative spectratyping demonstrated that PM relapse features dramatically perturbed blood T-cell repertoires but is not associated with the emergence of new T-cell clones. It is striking that patients in remission also maintained all their T-cell repertoire abnormalities. The clonally expanded T-cells displayed a memory phenotype, expressed intracellular perforin, and dramatically responded to IL-2, showing a potential to be reactivated upon appropriate conditions. These results indicate that persistent T-cell clonal expansion is an important feature of polymyositis.
Benveniste
Olivier
O
Service de Médecine Interne, Hôpital Pitié-Salpêtrière, Paris, France. olivier.benveniste@psl.ap-hop-paris.fr
Herson
Serge
S
Salomon
Benoît
B
Dimitri
Dalia
D
Trébeden-Nègre
Hélène
H
Jean
Laetitia
L
Bon-Durand
Véronique
V
Antonelli
David
D
Klatzmann
David
D
Boyer
Olivier
O
D049109:Cell Proliferation; D002478:Cells, Cultured; D002999:Clone Cells; D006801:Humans; D008213:Lymphocyte Activation; D017285:Polymyositis / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology*; D013997:Time Factors