title: Dipole density of low-frequency and spike magnetic activity: a reliable procedure in presurgical evaluation of temporal lobe epilepsy.
abstract: Conventional visual analysis and dipole density analysis of magnetoencephalographic data for both spike and low-frequency magnetic activity were compared for presurgical evaluation in temporal lobe epilepsy (TLE) in a sample of 26 drug-resistant operated TLE patients. A series of logistic regression analyses were performed. Dipole density sensitivity was superior to visual localization analysis. Three separated logistic models were calculated for interictal spikes, low-frequency magnetic activity, and the combination of both measures. A combined interictal spike/low-frequency magnetic activity model predicted correctly the operated temporal lobe in all patients. Clear-cut criteria for the probability model are proposed that are valid for 92.3% of cases in the sample. The quantitative approach proposed by this study is an evidence-based model for presurgical evaluation of temporal lobe epilepsy, which improves previous magnetoencephalographic investigations and establishes working clinical criteria for patient evaluation in TLE.
authors.affiliation: Centro MEG Dr. Pérez Modrego, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández
authors.forename: Rafael G
authors.initials: RG
authors.lastname: de Sola
authors.forename: Carlos
authors.initials: C
authors.lastname: Amo
authors.forename: Agustín
authors.initials: A
authors.lastname: Turrero
authors.forename: Pilar
authors.initials: P
authors.lastname: Zuluaga
authors.forename: Fernando
authors.initials: F
authors.lastname: Maestú
authors.forename: Pablo
authors.initials: P
authors.lastname: Campo
authors.forename: Tomás
authors.initials: T
authors.lastname: Ortiz
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D016015:Logistic Models; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011300:Preoperative Care