title: Asymmetric hydrogenation of ketones using a ruthenium(II) catalyst containing BINOL-derived monodonor phosphorus-donor ligands.
abstract: [structure: see text] A series of ruthenium(II) complexes containing BINOL-based monodonor phosphorus ligands have been prepared and applied to the asymmetric catalysis of the hydrogenation of aryl/alkyl ketones. The best ligands for this application are those which contain an aromatic groups with either a methoxide or bromide on the ortho position. Using these ligands, alcohols with ee's of up to 99% are formed.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Xu
authors.forename: Nat W
authors.initials: NW
authors.lastname: Alcock
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Clarkson
authors.forename: Gordon
authors.initials: G
authors.lastname: Docherty
authors.forename: Gary
authors.initials: G
authors.lastname: Woodward
authors.forename: Martin
authors.initials: M
authors.lastname: Wills