[Effect of corundum-vancomycin composite on soft tissue reaction].
The ceramics on the basis of corundum is used for implantation in the form of porous and solid materials. The solid form was used to produce tissue endoprosthesis while porous form is mainly used to fill in the bone defects. The corundum ceramics are also known to be used as coatings for implants in orthopedics and dentistry. On the other hand there is still a need to find out the new way of treatment of the chronic bone infection, during which the traditional way of antibiotics therapy is no more effective. One of the possibly solution is to use the different biomaterials as drug carriers and in the bone surgery one of the best are porous corundum implants, being themselves of high biocompatibility, and additionally containing Vancomycin. The main target of the investigation presented in this paper was the comparative assessment of the corundum ceramics and its composite containing Vancomycin after implantation into back muscle of the total of 15 rats. During the post mortem macroscopic assessment in the tissues which surrounded the implants there were no any inflammatory neither pathological changes observed. In the microscopic findings, in early periods, the observed inflammatory tissue reaction for implants with vancomycin was significantly greater what could be explained by the high concentration of the antibiotic in the given material. On the basis of the results of macroscopic and microscopic findings we can state that the composite material of corundum ceramic containing vancomycin is of high compatibility and could be regarded as the good drug carrier.
Rusiecki
Marek
M
Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów Akademii, Medycznej we Wrocławiu.
Pielka
Stanisław
S
Rutowski
Roman
R
Paluch
Danuta
D
Staniszewska-Kuś
Jolanta
J
Solski
Leszek
L
D000537:Aluminum Oxide / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology*; D002516:Ceramics; D004337:Drug Carriers; D005260:Female; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D014640:Vancomycin; D000537:Aluminum Oxide