Oxidative stress in colon tissue induced by vitamin E depletion.
Inflammatory disorders of the bowel and colon cancer are associated with elevated indices of oxidative stress. Analogous elevations in markers of oxidative stress and loss of cell-membrane integrity are also observed in the colons of rats deficient in vitamin E (D-alpha-tocopherol), the major lipid-soluble antioxidant in biological systems. The causal relationship between colon pathologies associated with oxidative stress and dietary deficiency in antioxidant vitamins such as vitamin E is still uncertain. Investigation of potential mechanisms by which lack of dietary vitamin E may lead to clinically relevant pathological changes in colon tissue was conducted using gene expression profiling strategies on vitamin E-sufficient and -deficient rats. Morphological changes and increased indices of lipid peroxidation were linked to vitamin E deficiency. These changes in colon tissue are potentially important in disease pathogenesis of the colon linked with oxidative stress or other direct consequences of inadequate levels of vitamin E.
Drew
J E
JE
Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK. jed@rowett.ac.uk
Mercer
D K
DK
Mayer
C
C
Farquharson
A J
AJ
Morrice
P C
PC
Arthur
J R
JR
Duthie
G G
GG
D000818:Animals; D003106:Colon / Q000503:physiopathology*; D005786:Gene Expression Regulation / Q000502:physiology; D015227:Lipid Peroxidation; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014811:Vitamin E Deficiency / Q000503:physiopathology*; D024502:alpha-Tocopherol / Q000097:blood / Q000378:metabolism
D024502:alpha-Tocopherol