[Assessment of prognostic factors in common ovarian tumors of varying malignancy].
OBJECTIVE
The outcome and prognosis of apparently similar cases of epithelial ovarian cancers with the same histology and stage is highly variable. The objective was to compare survival and prognostic factors of patients treated at the 1st Department of Obstetrics and Gynecology of Semmelweis University between 1993-2003 with the similar data of the 25th Annual Report on the Results of Treatment in Gynecological Cancer of FIGO. In addition, the aim was to assess the prognostic value of MMP activities and fibronectin concentration in ovarian tumour patients.


METHODS
The 25th Annual Report of FIGO included 5694 patients with ovarian tumours from 32 countries diagnosed and treated between 1995 and 1998. Hungary did not participate in this report. Between 1993 and 2003, 180 patients with common epithelial ovarian tumours had been treated at the 1st Department of Obstetrics and Gynecology of Semmelweis University. Treatment and survival data derived from medical record review and from the Population Register Office. In order to compare different prognostic factors, a multivariate Cox proportional regression analysis was performed. The authors measured MMP activities in 33 surgically removed ovarian tumours, serum and ascites by applying zymographic technique. Fibronectin content was determined by Western blot analysis and quantitated by densitometry.


RESULTS
The 5-year survival was 90.0% and 30.9% in the case of ovarian tumours with low malignant potential and of epithelial ovarian cancers, respectively. Multivariate analysis identified adverse prognostic factors including advanced age (>60 years) and stage, high grade and suboptimal operation with residual macroscopic disease and the presence of ascites. However, the histological type was not identified to be an adverse prognostic factor in this study. No correlation could be seen between the histology of the ovarian tumours and the elevation of MMP-2/9 activity. More interestingly, however, MMP-9 expression and fibronectin concentration were significantly elevated and the activated forms of both MMP-9 and MMP-2 were more frequent in ovarian cancer patients who developed recurrent disease.


CONCLUSIONS
A great deal of effort should be devoted to identification of further prognostic factors to improve treatment of ovarian cancer. These prognostic factors might help to identify those ovarian cancer patients at the time of diagnosis whose disease will have unfavourable outcome. Our data support the notion that high expression of MMP-9 and fibronectin indicates poor prognosis of ovarian cancer patients.
Demeter
Attila
A
I. sz. Szülészeti és Nôgyógyászati Klinika, Semmelweis Egyetem AOK, Budapest 1088, Hungary. demeter@noi1.sote.hu
Várkonyi
Tibor
T
Csapó
Zsolt
Z
Szánthó
András
A
Oláh
Julianna
J
Papp
Zoltán
Z
D018262:Adenocarcinoma, Clear Cell / Q000150:complications / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000150:complications / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D001201:Ascites / Q000209:etiology; D015153:Blotting, Western; D002277:Carcinoma / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D018269:Carcinoma, Endometrioid / Q000150:complications / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D012307:Risk Factors