title: Spinal cord compression and lung metastasis of Wilms' tumor in a pregnant adolescent.
abstract: Wilms' tumor in adults is rare, and no treatment guidelines have been established. Spinal cord compression has also been rarely reported in all age groups. In this case report, we present a 19-year-old adolescent with recurrent Wilms' tumor, a paraspinal dumbbell mass, metastatic involvement of the vertebral bodies, lung metastasis, and pregnancy. To our knowledge, this is the first report of a pregnant patient with Wilms' tumor who had to undergo immediate chemotherapy with vincristine and actinomycin-D owing to spinal cord compression at 25 weeks of pregnancy. After delivery, complete remission was maintained with a regimen of ifosfamide, carboplatin, and etoposide and vincristine, actinomycin-D, and cyclophosphamide. No teratogenic or other toxic effects of vincristine or actinomycin-D were observed in the fetus.
authors.affiliation: Department of Pediatric Oncology, Kocaeli University, Izmit-Kocaeli, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Corapcioglu
authors.forename: Ozdal
authors.initials: O
authors.lastname: Dillioğlugil
authors.forename: Nazan
authors.initials: N
authors.lastname: Sarper
authors.forename: Gür
authors.initials: G
authors.lastname: Akansel
authors.forename: Muhittin
authors.initials: M
authors.lastname: Calişkan
authors.forename: A Engin
authors.initials: AE
authors.lastname: Arisoy
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D003907:Dexamethasone / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000150:complications* / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D008159:Lumbar Vertebrae; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010352:Patient Dropouts; D011128:Polyradiculopathy / Q000209:etiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D012074:Remission Induction; D013117:Spinal Cord Compression / Q000209:etiology*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects; D009396:Wilms Tumor / Q000150:complications* / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003907:Dexamethasone; D003520:Cyclophosphamide; D016190:Carboplatin; D007069:Ifosfamide