title: Pituicytoma.
abstract: Pituicytoma is a rare, low-grade neoplasm that originates in the neurohypophysis of the pituitary gland. We report the clinicopathologic features of a pituicytoma arising in a 52-year-old man who presented with a mass and panhypopituitarism, clinically suggestive of a pituitary adenoma. The tumor was marked by a proliferation of elongated cells arranged in bundles and interlacing fascicles. The tumor demonstrated positive staining with S-100 protein and glial fibrillary acid protein antibodies. The tumor did not stain with antibodies to cytokeratin, synaptophysin, chromogranin, anterior pituitary hormones, or p53. An MIB-1 labeling index of 1.1% was observed. The tumor was subtotally resected and recurred 11 months after the initial surgery. The literature on this rare tumor will be reviewed and differential diagnosis discussed.
authors.affiliation: Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Kowalski
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
authors.forename: Marc R
authors.initials: MR
authors.lastname: Mayberg
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D003131:Combined Modality Therapy; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010904:Pituitary Gland, Posterior / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D009418:S100 Proteins