Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp.
A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class A carbapenem-hydrolyzing enzyme, KPC-2 beta-lactamase, was isolated from a patient with sepsis at a Boston hospital. This is the first report of the production of a plasmid-encoded KPC-2 beta-lactamase by an Enterobacter sp.
Hossain
Ashfaque
A
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.
Ferraro
M J
MJ
Pino
R M
RM
Dew
R B
RB
Moland
E S
ES
Lockhart
T J
TJ
Thomson
K S
KS
Goering
R V
RV
Hanson
N D
ND
D015780:Carbapenems / Q000378:metabolism*; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004754:Enterobacter / Q000201:enzymology* / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D010957:Plasmids / Q000235:genetics*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
D015780:Carbapenems; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases