[Ultrasonographic evaluation of the venous tone in humans in the clinical pharmacology of venotropic drugs].
A new ultrasonographic method of evaluation of the venous tone in humans is described and experimentally justified. The method is based on the principles of venous occlusion plethysmograhy and ultrasonographic two-dimensional imaging of the cross section of cubital veins. It is found that an increment of the cross-sectional area of the vein is correlated with a change in the volume of distal segment of the upper extremity according to the data of aqueous plethysmography. The tests with nitroglycerin and dihydroergotamine (vasoactive drugs producing opposite effects upon the venous tone) confirmed the possibility of using this technique in the clinical pharmacology of venotropic drugs.
Modin
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Shashkov
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D000328:Adult; D004087:Dihydroergotamine / Q000494:pharmacology; D004341:Drug Evaluation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology; D010991:Plethysmography; D014463:Ultrasonography / Q000379:methods*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*; D014680:Veins / Q000000981:diagnostic imaging* / Q000187:drug effects
D004087:Dihydroergotamine; D005996:Nitroglycerin