title: [A case of successful management of nonresectable pancreas cancer with liver metastasis by intra-arterial infusion chemotherapy with gemcitabine hydrochloride, 5-FU, CDDP and administration of tegafur/uracil].
abstract: We report a case of a 43-year-old man with liver metastasis of advanced pancreatic cancer successfully treated with intra-arterial regional chemotherapy. The patient was admitted to our hospital suffering from anorexia and back pain. Abdominal CT showed pancreatic tail cancer with liver and Schnitzler metastasis. We decided a curative operation was impossible. Then, enteric-coated tegafur/uracil (400 mg) was administered. Simultaneously, intraarterial infusion with CDDP, 5-fluorouracil (500 mg) and infusion of gemcitabine (1,000 mg) with 50 microg of AT-II was given once a week. After 3 courses, the pancreatic tumor was reduced and the tumor markers decreased. Multiple metastatic liver tumors remarkably decreased. As a result, the maximum diameter of the pancreatic tumor decreased from 7 cm to 5 cm on the CT-scan. Serum carbohydrate antigen 19-9 (CA19-9) decreased from 122,000 U/ml to 10,200 U/ml. Moreover, the performance status of patient also improved. He was able to receive outpatient treatment despite his terminal cancer. Furthermore, the patient can take sufficient meals without any adverse effects. His quality of life has been preserved. This regimen could well be effective for advanced pancreatic cancer.
authors.affiliation: Dept. of Gastroenterology, Saiseikai Niigata Second Hospital.
authors.forename: Toru
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Mizuno
authors.forename: Kouji
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Baba
authors.forename: Hironobu
authors.initials: H
authors.lastname: Oota
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yoshida
authors.forename: Tomoteru
authors.initials: T
authors.lastname: Kamimura
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011788:Quality of Life; D005641:Tegafur / Q000008:administration & dosage*; D014498:Uracil / Q000008:administration & dosage*; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; C096910:UFT(R) drug; D003841:Deoxycytidine; D005641:Tegafur; D014498:Uracil; D002945:Cisplatin; D005472:Fluorouracil; D000093542:Gemcitabine