title: [Study on the expression of proto-oncogene eIF4E in laryngeal squamous carcinoma].
abstract: OBJECTIVE
  To investigate the expression of the proto-oncogene eIF4E in laryngeal squamous cell carcinoma and its relationship with clinical pathology.
  
  
  METHODS
  Sections of 37 samples of laryngeal squamous cell carcinoma (LSCC) and 10 samples of vocal cords polyp were analyzed with anti-eIF4E polyclonal antibody utilizing SP (Streptavidin Peroxidase) immunohistochemical technique.
  
  
  RESULTS
  All 37 LSCC samples overexpressed eIF4E in the tumors (eIF4E score: 30 approximately 210), whereas no staining was observed in 10 samples of vocal cords polyp (eIF4E score: 0). There was a significant correlation between overexpression of protein eIF4E with T stage, N stage, histological grade, recurrence and the states of metastases (P < 0.01). It did not correlate with age, sex, and site of tumor (P > 0.05).
  
  
  CONCLUSIONS
  The eIF4E plays an important role on tumorgenesis, development, invasion and metastases of laryngeal squamous cell carcinoma. There was a correlation between the overexpression of protein eIF4E with TNM stage, histological grade, recurrence and metastases. eIF4E in the laryngeal squamous cell carcinoma can be considered as an independent prognostic factor and tumour molecular marker.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200001.
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Luying
authors.initials: L
authors.lastname: Zheng
authors.forename: Yuping
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D039561:Eukaryotic Initiation Factor-4E / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D000090063:Proto-Oncogene Mas
chemical_list: D039561:Eukaryotic Initiation Factor-4E; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas