Silylstannylation of highly functionalized acetylenes. synthesis of precursors for annulations via radical or Heck reactions.
[reaction: see text] Pd-catalyzed silylstannylation of acetylenes tolerates a variety of reactive functional groups (aldehydes, nonterminal acetylenes, epoxides, activated and unactivated olefins), providing easy access to precursors that can be converted into carbocyclic and heterocyclic compounds via free radical or Heck reactions. Examples of the synthesis of pyrrolidines, bicyclic beta-lactams, hydrindanes, and tetrahydrofurans are described.
Apte
Sandeep
S
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Radetich
Branko
B
Shin
Seunghoon
S
RajanBabu
T V
TV