[Surveillance of resistance of Mycobacterium tuberculosis to anti-TB drugs in Cuba, 1995-1998].
Drug-resistance surveillance by means of culture and drug susceptibility test (DST) allows the estimation of the regional and global magnitude of multidrug-resistance (MDR). Two reports on anti-tuberculosis drug resistance by the WHO/IUATLD showed that drug-resistance TB varied widely across regions. This work determined the prevalence of drug resistance among new cases and among previously treated cases of tuberculosis in Cuba during the period 1995-1998. Drug resistance was determined using the proportion method in 1379 Mycobacterium tuberculosis strains to first line antituberculosis drugs (isoniazid, streptomycin, ethambutol and rifampicin). The resistance in new cases was 8.3% and 6.5%; MDR was 0.7% and 0% in the first and second study respectively. The contributed data through Cuba demonstrated that our country is relatively free of MDR strains, recognizing it to world level the good tuberculosis-control programs and the success of the application in our country of the directly-observed-treatment strategy from the year 1971.
Montoro
Ernesto
E
Laboratorio Nacional de Referencia e Investigaciones en Tuberculosis y Micobacterias, Centro Colaborador OPS/OMS, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba. emontoro@ipk.sld.cu
Echemendía
Miguel
M
Lemus
Dihadenys
D
Marrero
Antonio
A
Llanes
María J
MJ
Valdivia
José A
JA
D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003462:Cuba; D024881:Drug Resistance, Bacterial; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011159:Population Surveillance; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology
D000995:Antitubercular Agents