title: Treatment of periapical inflammatory lesion with the combination of platelet-rich plasma and tricalcium phosphate: a case report.
abstract: Periapical surgery is an important treatment alternative in the presence of a periapical inflammatory lesion. To achieve optimal healing and regeneration of the bone, different bone substitutes or barrier membranes can be used after degranulation of the lesion. Tricalcium phosphate (TCP) graft material is one of these substitutes. Platelet Rich Plasma (PRP) preparation is a new biotechnology and can be used in many different surgical procedures. It consists of thrombocyte concentrates and high amounts of growth factors (GFs), especially platelet derived growth factor (PDGF), insulin-like growth factor (IGF-I) and transforming growth factor (TGF-beta), which are important in wound healing and regeneration. In this case report, use of platelet gel in conjunction with TCP in the treatment of periapical inflammatory lesion and the results of 12 months has been reported.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. bdemirip@ttnet.net.tr
authors.forename: Burak
authors.initials: B
authors.lastname: Demiralp
authors.forename: Hüseyin Gencay
authors.initials: HG
authors.lastname: Keçeli
authors.forename: Mehmet
authors.initials: M
authors.lastname: Muhtaroğullar
authors.forename: Ahmet
authors.initials: A
authors.lastname: Serper
authors.forename: Bahtiyar
authors.initials: B
authors.lastname: Demiralp
authors.forename: Kenan
authors.initials: K
authors.lastname: Eratalay
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery*; D001792:Blood Platelets; D001861:Bone Regeneration; D018786:Bone Substitutes; D002130:Calcium Phosphates; D012534:Dental Scaling; D005500:Follow-Up Studies; D005782:Gels; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010485:Periapical Periodontitis / Q000601:surgery*; D010956:Plasmapheresis; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D012390:Root Canal Therapy; D016212:Transforming Growth Factor beta / Q000627:therapeutic use
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D005782:Gels; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; C485817:beta-tricalcium phosphate; D007334:Insulin-Like Growth Factor I