[Study on the changes of electrocardiogram and ultrastructural in heroin dependence in rats].
OBJECTIVE
To study the changes of electrocardiograms (ECG) and myocardial ultrastructure in heroin dependence in rats, in order to reveal the mechanisms of the myocardial injury by heroin.


METHODS
Establish heroin addict model in SD mice, investigate the changes in electrocardiograms, HE staining and myocardial ultrastructure.


RESULTS
The electrocardiograms of the addict group had prominently changes, main expressions: heart rate decreased, P wave and T wave amplitude reduced and duration increased, S-T reduced and duration increased, QT interval prolongation, these changes indicated that myocardium had been injured, myocardial ischemia, ventricle function declined. These difference was significant (P<0.05) between before inject heroin and after inject heroin. Transformations in the ultrastructure: nuclear concentrate, reduce, nuclear membrane shrink, chromatin agglutinate, mitochondria cristal had disorder formation, disappeared or hollowed, these indicated that heroin could cause pathological changes in myocardial ultrastructure.


CONCLUSIONS
Above-mentioned changes indicated that heroin can injure myocardium, and the changes of myocardial ultrastructure suggested that myocardial apoptosis may be one of the mechanisms of the myocardial injury by heroin.
Liu
Xiao-shan
XS
Department of Forensic Medicine, Medical Center of Zhongshan University, Guanzhou 510080, China. lxsa@gzsums.edu.cn
Chen
Yu-chuang
YC
Li
Zhao-hui
ZH
D000818:Animals; D004195:Disease Models, Animal; D004562:Electrocardiography; D006339:Heart Rate; D006556:Heroin Dependence / Q000473:pathology / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure*; D051381:Rats; D017207:Rats, Sprague-Dawley