Evidence for biliary excretion of vancomycin into stool during intravenous therapy: potential implications for rectal colonization with vancomycin-resistant enterococci.
Sixty-three stool samples and five bile samples were prospectively collected from 33 patients receiving intravenous vancomycin therapy and were quantitatively analyzed for vancomycin by a competitive immunoassay. Vancomycin was excreted via bile into the stools of almost all patients at concentrations of 3.3 to 94.8 microg/ml after >/=5 days of a therapy of 1 g every 12 h.
Currie
Brian P
BP
Montefiore Medical Center, 111 E. 210th St., Bronx, NY 10467, USA. bcurrie@montefiore.org
Lemos-Filho
Luciano
L
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry; D001646:Bile / Q000378:metabolism*; D019729:Carbon-Oxygen Ligases / Q000737:chemistry; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination / Q000378:metabolism; D016983:Enterococcus / Q000187:drug effects*; D005243:Feces / Q000737:chemistry* / Q000382:microbiology; D016231:Fluorescence Polarization Immunoassay; D005839:Gentamicins / Q000378:metabolism; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D007275:Injections, Intravenous; D012007:Rectum / Q000382:microbiology*; D014640:Vancomycin / Q000008:administration & dosage / Q000378:metabolism*; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D005839:Gentamicins; C071437:VanA ligase, Bacteria; D014640:Vancomycin; D019729:Carbon-Oxygen Ligases