Effects of flavonoids on the resistance of microsomes to lipid peroxidation in vitro and ex vivo.
Incubation of rat liver microsomes with preparations of grape flavonoids, dihydroquercetin, and silibinin increased their resistance to lipid peroxidation induced by NADPH-Fe2+. This was manifested in less pronounced accumulation of lipid peroxidation products and changes in activity of microsomal enzymes induced by lipid peroxidation. In vitro antioxidant activity of grape flavonoids markedly surpassed that of dihydroquercetin and silibinin. Addition of flavonoids into fodder led to moderate, statistically significant, and similar increase in the resistance of rat liver microsomes to ex vivo induced lipid peroxidation.
Kravchenko
L V
LV
Institute of Nutrition, Russian Academy of Medical Sciences, Moscow.
Morozov
S V
SV
Tutel'yan
V A
VA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D044948:Flavonols / Q000302:isolation & purification / Q000494:pharmacology; D028221:Larix / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D020944:Silybum marianum / Q000737:chemistry; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000077385:Silybin; D012838:Silymarin / Q000302:isolation & purification / Q000494:pharmacology; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D027843:Vitis / Q000737:chemistry
D000975:Antioxidants; D005419:Flavonoids; D044948:Flavonols; D010936:Plant Extracts; D012838:Silymarin; D017392:Thiobarbituric Acid Reactive Substances; D000077385:Silybin; D011794:Quercetin; C003377:taxifolin; D009251:NADPH-Ferrihemoprotein Reductase