title: Spectrophotometric analysis of raloxifene hydrochloride in pure and pharmaceutical formulations.
abstract: Two simple and sensitive spectrophotometric methods (A and B) for the determination of raloxifene hydrochloride in bulk samples and pharmaceutical formulations are described. Method A is based on the oxidation of the drug with ferric chloride and coupling with potassium ferric cyanide. Method B is based on reduction of the drug with Fehling's reagent. Bluish green color formed in method A absorbs at 735 nm and brown color produced in method B absorbs at 430 nm.
authors.affiliation: K.M.C.H. College of Pharmacy, Kovai Estate, Coimbatore, India. dharumanj@yahoo.com
authors.forename: J
authors.initials: J
authors.lastname: Dharuman
authors.forename: V
authors.initials: V
authors.lastname: Ravichandran
authors.forename: N
authors.initials: N
authors.lastname: Thirumoorthy
authors.forename: A
authors.initials: A
authors.lastname: Dharamsi
mesh_terms: D002626:Chemistry, Pharmaceutical; D002712:Chlorides; D005290:Ferric Compounds; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D020849:Raloxifene Hydrochloride / Q000032:analysis*; D012015:Reference Standards; D020845:Selective Estrogen Receptor Modulators / Q000032:analysis*; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
chemical_list: D002712:Chlorides; D005290:Ferric Compounds; D007202:Indicators and Reagents; D020845:Selective Estrogen Receptor Modulators; D012996:Solutions; D013607:Tablets; D020849:Raloxifene Hydrochloride; C024555:ferric chloride