title: Surgical outcome of serosa-negative advanced gastric carcinoma.
abstract: The purpose of the present study was to clarify prognostic factors and to investigate appropriate therapeutic strategies for T2 gastric carcinoma. A total of 297 consecutive patients with T2 gastric carcinoma (T2a; 130, T2b; 167) were enrolled in this study. The overall 5-year survival rate was 75.3%. There was a significant difference in survival between T2a and T2b tumor. Multivariate analysis showed that age, depth of invasion and lymph node metastasis independently influenced prognosis. Peritoneal recurrence was frequently observed in 37 patients. Multivariate analysis revealed that lymph node metastasis was an independent predictive factor for peritoneal recurrence. Furthermore, the quantity of the stroma was an independent prognostic factor for hematogenous metastasis, and lymph node metastasis for lmphatic metastasis. Prophylactic therapeutic strategy should be advised for patients with many metastatic lymph nodes, for peritoneal or lymphatic recurrence and in patients with "medullary" stroma for hematogenous recurrence.
authors.affiliation: Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Yokohama, Japan. s0714@med.yokohama-cu.ac.jp
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimada
authors.forename: Masato
authors.initials: M
authors.lastname: Nomura
authors.forename: Goro
authors.initials: G
authors.lastname: Matsuda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Otsuka
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Ono
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Akiyama
mesh_terms: D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012704:Serous Membrane / Q000473:pathology; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome