Antimicrobial and antileishmanial activities of hypocrellins A and B.
Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.
Ma
Guoyi
G
The National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Khan
Shabana I
SI
Jacob
Melissa R
MR
Tekwani
Babu L
BL
Li
Zuqiang
Z
Pasco
David S
DS
Walker
Larry A
LA
Khan
Ikhlas A
IA
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007893:Leishmania donovani / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009894:Opportunistic Infections / Q000382:microbiology; D010569:Perylene / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019800:Phenol; D011809:Quinones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D011809:Quinones; D019800:Phenol; D010569:Perylene; C048388:hypocrellin A; C064522:hypocrellin B