[Effect of jianxin pinglu pill on arrhythmia and aquaporin 4 expression in rats with myocardial ischemia/reperfusion injury].
OBJECTIVE
To explore the effect of jianxin pinglu pill (JPP) on arrhythmia and aquaporin 4 (AQP4) in rats with myocardial ischemia/reperfusion (I/R) injury.


METHODS
The effects of JPP on arrhythmia, mortality and AQP4 on I/R injured rats model induced by blocking left coronary artery were observed using II lead of ECG, HE stain and AQP4 immunohistochemical stain.


RESULTS
JPP showed significant effect in lowering the arrhythmia occurrence and mortality, reducing myocardial ischemic edema and injury, strengthening AQP4 expression in myocardial tissue.


CONCLUSIONS
JPP has the effect of preventing I/R induced arrhythmia, it might be related with its action in up-regulating AQP4 expression level in myocardium and reducing the intracellular edema.
He
Xu-ping
XP
Department of Internal Medicine, Shenzhen Municipal Hospital of TCM, Guangdong (518033). hxp-szzy@163.net
Chen
Dong-feng
DF
Zheng
Jian-hong
JH
Du
Shaohui
S
Deng
Bin
B
Zhang
Shangbin
S
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D051401:Aquaporin 4; D020346:Aquaporins / Q000032:analysis / Q000096:biosynthesis*; D001145:Arrhythmias, Cardiac / Q000378:metabolism* / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000150:complications* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; C496032:Aqp4 protein, rat; D051401:Aquaporin 4; D020346:Aquaporins; D004365:Drugs, Chinese Herbal