Marked elevation of soluble fas ligand and cytokine secretion after splenectomy in aggressive natural killer cell leukemia/lymphoma.
We report a case of Epstein-Barr virus-associated aggressive natural killer cell leukemia/lymphoma with giant splenomegaly in which splenectomy resulted in progression of apoptosis and hemophagocytosis. The serum level of ferritin, triglycerides, interferon-gamma (IFN-gamma), interleukin 10 (IL-10), and soluble Fas ligand (sFasL) increased markedly, and liver damage progressed after splenectomy. The number of apoptotic cells in peripheral blood smears increased following splenectomy. In the present case, splenectomy caused disruption of the cytokine network, resulting in apoptosis of blood cells and hepatocytes, as well as phagocytosis.
Kaizu
Kiyohiko
K
Department of Pediatrics, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Maeda
Miho
M
Ohkawa
Takuya
T
Hayashida
Mari
M
Nakajima
Seiko
S
Sugisaki
Yuichi
Y
Fukunaga
Yoshitaka
Y
D000293:Adolescent; D017209:Apoptosis; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D053222:Fas Ligand Protein; D017809:Fatal Outcome; D005293:Ferritins / Q000097:blood; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D007694:Killer Cells, Natural / Q000166:cytology*; D007938:Leukemia / Q000097:blood* / Q000628:therapy; D008099:Liver / Q000293:injuries; D008223:Lymphoma / Q000097:blood* / Q000628:therapy; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D010587:Phagocytosis; D013156:Splenectomy; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D016207:Cytokines; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D014280:Triglycerides; D016753:Interleukin-10; D007371:Interferon-gamma; D005293:Ferritins