title: Phytochemical determination and extraction of Momordica charantia fruit and its hypoglycemic potentiation of oral hypoglycemic drugs in diabetes mellitus (NIDDM).
abstract: Momordica charantia (MC) fruit was subjected to phytochemical and pharmacological interaction studies with oral hypoglycemis in NIDDM patients. Phytochemical, chromatographical analysis and extraction of methanolic MC fruit soft (semi-solid form) in CCl4 + C6H6 solvent system yielded 15 diverse chemical constituents--alkaloids, glycosides, aglycone, tannin, sterol, phenol and protein. The CCl4 + C6H6 MC soft extract was used orally in a dose of 200 mg twice daily (BD) for pharmacological interactions with two diversely acting oral hypoglycemic agents--1) metformin BD and 2) glibenclamide BD in 15 patients of either sex (52-65 years of age) of NIDDM. It was observed that with CCl4 + C6H6 MC soft extract plus half doses of metformin or glibenclamide or both in combination caused hypoglycemia greater than that caused by full doses used in the study with 7 days treatment. Conclusively the extract acts in synergism with oral hypoglycemics and potentiates their hypoglycemia in NIDDM.
authors.affiliation: Department of Chemistry, Govt Autonomous Holkar Science College, Devi Ahilya University, Indore-452 018.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Tongia
authors.forename: Sudhir Kumar
authors.initials: SK
authors.lastname: Tongia
authors.forename: Mangala
authors.initials: M
authors.lastname: Dave
mesh_terms: D000284:Administration, Oral; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005638:Fruit; D006801:Humans; D007003:Hypoglycemia / Q000097:blood; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008875:Middle Aged; D029777:Momordica charantia; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts