In vitro antiviral diterpenes from the Brazilian brown alga Dictyota pfaffii.
Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-di-hydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude ex-tract of D. pfaffii. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.
Barbosa
Jussara Pinheiro
JP
Post-Graduate Program in Organic Chemistry, Institute of Chemistry, Universidade Federal Fluminense, Niterói, 24001-970 Rio de Janeiro, Brazil.
Pereira
Renato Crespo
RC
Abrantes
Juliana Lourenço
JL
Cirne dos Santos
Cláudio César
CC
Rebello
Moacyr Alcoforado
MA
Frugulhetti
Izabel Christina de Palmer Paixão
IC
Texeira
Valéria Laneuville
VL
D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects*; D008519:Medicine, Traditional; D000459:Phaeophyceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014709:Vero Cells / Q000821:virology
D019380:Anti-HIV Agents; D004224:Diterpenes; D010936:Plant Extracts