Synthesis and antileishmanial profile of some novel terpenyl pyrimidines.
Some novel terpenyl pyrimidine derivatives 2(a-d) and 6(a-b) have been synthesised from alpha/beta-ionone keteneacetals 1 and 5. The terpenyl pyrimidine 2e has been synthesised from beta-ionone 3 in two steps in quantitative yield. The pyrimidine derivatives were screened for in-vivo antilesihmanial activity. The compounds 2d, 2e, 6a and 6b showed promising in-vivo antileishmanial activity.
Pandey
Susmita
S
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Suryawanshi
S N
SN
Gupta
Suman
S
Srivastava
V M L
VM
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006224:Cricetinae / Q000469:parasitology; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D007896:Leishmaniasis / Q000188:drug therapy*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013730:Terphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000981:Antiprotozoal Agents; D011743:Pyrimidines; D013730:Terphenyl Compounds