Palladium-catalyzed tandem cyclization/suzuki coupling reaction of 1,2,7-trienes.
[reaction: see text] A Pd(0)-catalyzed 1,2,7-triene cyclization/arylation cascade reaction was realized via pi-allylpalladium intermediate formation and a subsequent Suzuki coupling reaction to preferentially give a five-membered ring product with a stereodefined exocyclic double bond. Excellent cis/trans selectivity was achieved (only cis-3 was isolated) with heteroatom-tethered 1,2,7-triene substrates.
Zhu
Gangguo
G
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, and Graduate School of the Chinese Academy of Sciences, Shanghai 200032, China.
Zhang
Zhaoguo
Z