Mother-to-infant vertical transmission of transfusion transmitted virus in South China.
A nested PCR was used to detect TTV DNA in serum from 490 mother-infant pairs to determine the rate of vertical transmission of TTV in Guangzhou City, P.R. China. TTV DNA was positive in 87 mothers and 12 of their babies, giving a prevalence of 17.8% in pregnant women and a mother-to-child transmission rate of 13.8%. In eight mother-infant pairs, TTV DNA nucleotide sequences from the mothers and their corresponding infants were identical. The homology of Guangzhou TTV and Japanese TTV ranged from 85.3%-98.2% at nucleotide level. TTV infection is common in pregnant women in South China and vertical transmission can occur. Guangzhou's and Japanese TTV isolates belong to the same genotype.
Xin
Xiao
X
Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China. txin@jnu.edu.cn
Xiaoguang
Zhou
Z
Ninghu
Zhu
Z
Youtong
Luo
L
Liumei
Xu
X
Boping
Zhou
Z
D001483:Base Sequence; D002681:China / Q000453:epidemiology; D017931:DNA Primers; D004266:DNA Virus Infections / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000821:virology; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification*
D017931:DNA Primers; D004279:DNA, Viral