title: Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype.
abstract: Tetraodon nigroviridis is a freshwater puffer fish with the smallest known vertebrate genome. Here, we report a draft genome sequence with long-range linkage and substantial anchoring to the 21 Tetraodon chromosomes. Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to be absent in fish. Comparison with other vertebrates and a urochordate indicates that fish proteins have diverged markedly faster than their mammalian homologues. Comparison with the human genome suggests approximately 900 previously unannotated human genes. Analysis of the Tetraodon and human genomes shows that whole-genome duplication occurred in the teleost fish lineage, subsequent to its divergence from mammals. The analysis also makes it possible to infer the basic structure of the ancestral bony vertebrate genome, which was composed of 12 chromosomes, and to reconstruct much of the evolutionary history of ancient and recent chromosome rearrangements leading to the modern human karyotype.
authors.affiliation: UMR 8030 Genoscope, CNRS and Université d'Evry, 2 rue Gaston Crémieux, 91057 Evry Cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Jaillon
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Aury
authors.forename: Frédéric
authors.initials: F
authors.lastname: Brunet
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Petit
authors.forename: Nicole
authors.initials: N
authors.lastname: Stange-Thomann
authors.forename: Evan
authors.initials: E
authors.lastname: Mauceli
authors.forename: Laurence
authors.initials: L
authors.lastname: Bouneau
authors.forename: Cécile
authors.initials: C
authors.lastname: Fischer
authors.forename: Catherine
authors.initials: C
authors.lastname: Ozouf-Costaz
authors.forename: Alain
authors.initials: A
authors.lastname: Bernot
authors.forename: Sophie
authors.initials: S
authors.lastname: Nicaud
authors.forename: David
authors.initials: D
authors.lastname: Jaffe
authors.forename: Sheila
authors.initials: S
authors.lastname: Fisher
authors.forename: Georges
authors.initials: G
authors.lastname: Lutfalla
authors.forename: Carole
authors.initials: C
authors.lastname: Dossat
authors.forename: Béatrice
authors.initials: B
authors.lastname: Segurens
authors.forename: Corinne
authors.initials: C
authors.lastname: Dasilva
authors.forename: Marcel
authors.initials: M
authors.lastname: Salanoubat
authors.forename: Michael
authors.initials: M
authors.lastname: Levy
authors.forename: Nathalie
authors.initials: N
authors.lastname: Boudet
authors.forename: Sergi
authors.initials: S
authors.lastname: Castellano
authors.forename: Véronique
authors.initials: V
authors.lastname: Anthouard
authors.forename: Claire
authors.initials: C
authors.lastname: Jubin
authors.forename: Vanina
authors.initials: V
authors.lastname: Castelli
authors.forename: Michael
authors.initials: M
authors.lastname: Katinka
authors.forename: Benoît
authors.initials: B
authors.lastname: Vacherie
authors.forename: Christian
authors.initials: C
authors.lastname: Biémont
authors.forename: Zineb
authors.initials: Z
authors.lastname: Skalli
authors.forename: Laurence
authors.initials: L
authors.lastname: Cattolico
authors.forename: Julie
authors.initials: J
authors.lastname: Poulain
authors.forename: Véronique
authors.initials: V
authors.lastname: De Berardinis
authors.forename: Corinne
authors.initials: C
authors.lastname: Cruaud
authors.forename: Simone
authors.initials: S
authors.lastname: Duprat
authors.forename: Philippe
authors.initials: P
authors.lastname: Brottier
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Coutanceau
authors.forename: Jérôme
authors.initials: J
authors.lastname: Gouzy
authors.forename: Genis
authors.initials: G
authors.lastname: Parra
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lardier
authors.forename: Charles
authors.initials: C
authors.lastname: Chapple
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: McKernan
authors.forename: Paul
authors.initials: P
authors.lastname: McEwan
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bosak
authors.forename: Manolis
authors.initials: M
authors.lastname: Kellis
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Volff
authors.forename: Roderic
authors.initials: R
authors.lastname: Guigó
authors.forename: Michael C
authors.initials: MC
authors.lastname: Zody
authors.forename: Jill
authors.initials: J
authors.lastname: Mesirov
authors.forename: Kerstin
authors.initials: K
authors.lastname: Lindblad-Toh
authors.forename: Bruce
authors.initials: B
authors.lastname: Birren
authors.forename: Chad
authors.initials: C
authors.lastname: Nusbaum
authors.forename: Daniel
authors.initials: D
authors.lastname: Kahn
authors.forename: Marc
authors.initials: M
authors.lastname: Robinson-Rechavi
authors.forename: Vincent
authors.initials: V
authors.lastname: Laudet
authors.forename: Vincent
authors.initials: V
authors.lastname: Schachter
authors.forename: Francis
authors.initials: F
authors.lastname: Quétier
authors.forename: William
authors.initials: W
authors.lastname: Saurin
authors.forename: Claude
authors.initials: C
authors.lastname: Scarpelli
authors.forename: Patrick
authors.initials: P
authors.lastname: Wincker
authors.forename: Eric S
authors.initials: ES
authors.lastname: Lander
authors.forename: Jean
authors.initials: J
authors.lastname: Weissenbach
authors.forename: Hugues
authors.initials: H
authors.lastname: Roest Crollius
mesh_terms: D000818:Animals; D001482:Base Composition; D002875:Chromosomes / Q000235:genetics*; D002877:Chromosomes, Human / Q000235:genetics; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D005399:Fishes / Q000235:genetics*; D020440:Gene Duplication; D005796:Genes / Q000235:genetics; D016678:Genome; D006801:Humans; D007621:Karyotyping; D008322:Mammals / Q000235:genetics; D008957:Models, Genetic; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D020543:Proteome; D017422:Sequence Analysis, DNA; D026801:Synteny / Q000235:genetics; D014561:Urochordata / Q000235:genetics; D014714:Vertebrates / Q000235:genetics*
chemical_list: D020543:Proteome