title: An analysis of the association between respiratory symptoms in subjects with asthma and daily air pollution in Spokane, Washington.
abstract: The association between respiratory symptoms and ambient levels of particulate matter (PM) air pollution has been the focus of several panel studies. The majority of studies focused only on PM10, were conducted for relatively short periods, reported peak flow data, and involved children with asthma. The goal of our study was to evaluate the effect of particulate matter of various size fractions (PM10, PM2.5, PM1.0, and PM coarse fraction) on respiratory symptoms in both adults and children with asthma monitored over many months. Daily diary data on respiratory symptoms and medication use were collected. Air pollution data were collected by the local air agency and Washington State University. Data were collected in Spokane, WA, a semiarid city with diverse sources of particulate matter, including motor vehicles, woodstoves, agricultural burning, resuspended road dust, and dust storms. Sixteen adults and nine children living in Spokane participated in the study. The majority of adult subjects participated for over 1 yr and the children were studied for over 8 mo. In the children, we found a strong association between cough and PM10, PM2.5, PM coarse fraction, and PM1.0(p < .05). Sputum production and runny nose were associated with PM10and coarse fraction. However, no association was found between the presence of any respiratory symptom any PM metric in the adult subjects. These positive associations between various metrics of PM and respiratory symptoms in children suggest that children are more sensitive than adults to the effects of increased levels of PM air pollution or that the central site monitor was more representative for children who spend more time outdoors than adults. These findings also suggest that both larger and smaller particles can aggravate asthma symptoms.
authors.affiliation: Department of Environmental Health, University of Washington, Seattle, Washington, USA.
authors.forename: Therese F
authors.initials: TF
authors.lastname: Mar
authors.forename: Timothy V
authors.initials: TV
authors.lastname: Larson
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stier
authors.forename: Candis
authors.initials: C
authors.lastname: Claiborn
authors.forename: Jane Q
authors.initials: JQ
authors.lastname: Koenig
mesh_terms: D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects* / Q000737:chemistry; D001249:Asthma / Q000150:complications* / Q000175:diagnosis; D002648:Child; D003625:Data Collection / Q000379:methods*; D004781:Environmental Exposure / Q000009:adverse effects*; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D011058:Pollen / Q000009:adverse effects*; D012120:Respiration Disorders / Q000145:classification / Q000150:complications*; D013997:Time Factors; D014505:Urban Population; D014861:Washington / Q000453:epidemiology
chemical_list: D000393:Air Pollutants