title: PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.
abstract: The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod) score of 9.88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hatano
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: B
authors.initials: B
authors.lastname: Elibol
authors.forename: H
authors.initials: H
authors.lastname: Yoshino
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamura
authors.forename: V
authors.initials: V
authors.lastname: Bonifati
authors.forename: H
authors.initials: H
authors.lastname: Shinotoh
authors.forename: M
authors.initials: M
authors.lastname: Asahina
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: A R
authors.initials: AR
authors.lastname: Ng
authors.forename: R L
authors.initials: RL
authors.lastname: Rosales
authors.forename: S
authors.initials: S
authors.lastname: Hassin-Baer
authors.forename: Y
authors.initials: Y
authors.lastname: Shinar
authors.forename: C S
authors.initials: CS
authors.lastname: Lu
authors.forename: H C
authors.initials: HC
authors.lastname: Chang
authors.forename: Y H
authors.initials: YH
authors.lastname: Wu-Chou
authors.forename: F B
authors.initials: FB
authors.lastname: Ataç
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Toda
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: N
authors.initials: N
authors.lastname: Hattori
mesh_terms: D017668:Age of Onset; D001208:Asia / Q000453:epidemiology; D025063:Chromosome Disorders / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008877:Middle East / Q000453:epidemiology; D009154:Mutation / Q000235:genetics*; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D010375:Pedigree; D011494:Protein Kinases / Q000235:genetics*; D000099202:PTEN-Induced Putative Kinase
chemical_list: D005819:Genetic Markers; D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase