[Parameters of lipid peroxidation and low density lipoprotein (LDL) oxidation in the course of hyperthyroidism].
The aim of this study was to evaluate the influence of hyperthyroidism on lipid peroxidation and oxidative modification of low density lipoprotein (LDL). Twenty patients with hyperthyroidism due to Graves' disease or toxic multinodular goitre and 17 healthy subjects as the control group were investigated. Lipid peroxidation was measured by the serum level of malondialdehyde and 4-hydroxynonenal (MDA+4-HNE) whereas the oxidative modification of LDL was determined by measuring the serum levels of antibodies against oxidized LDL (anti-oxLDL). Ratios, which were evaluated as proportions of lipid peroxidation products level or anti-oxLDL level to the LDL-cholesterol level (LDL-C) were also determined: MDA+4-HNE/LDL-C and anti-oxLDL/LDL-C. The patients with hyperthyroidism displayed a significant elevation of the MDA+4-HNE/LDL-C ratio. The level of anti-oxLDL and anti-oxLD/LDL-C ratio were positively correlated with FT4 level and inversely correlated with HDL-cholesterol. These data suggest that the intensification of lipid peroxidation and oxidative modification of plasma lipoprotein is affected by changes in the level of thyroid hormones.
Lampka
Magdalena
M
Zakład Patobiochemii i Chemii Klinicznej AM w Bydgoszczy.
Nowicka-Lipska
Anna
A
Junik
Roman
R
Kopczyńska
Ewa
E
Paternoga
Agnieszka
A
Tyrakowski
Tomasz
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000447:Aldehydes / Q000097:blood; D000906:Antibodies / Q000097:blood; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000378:metabolism*; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood* / Q000276:immunology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged
D000447:Aldehydes; D000906:Antibodies; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D008315:Malondialdehyde; C027576:4-hydroxy-2-nonenal