title: [Antiarrhythmic properties of 2-(2'-hydroxy-2')-substituted ethyl-1,2,3,4-octahydropyrrolo[1,2-a]pyrazines].
abstract: The antiarrhythmic activity and acute toxicity of a series of 2-(2'-hydroxy-2')-substituted ethyloctahydropyrrolo[1,2-a]pyrazines were studied. Two most promising compound (PV-238) is characterized by high antiarrhythmic activity, broad spectrum of action, and low toxicity.
authors.forename: O V
authors.initials: OV
authors.lastname: Filippova
authors.forename: S A
authors.initials: SA
authors.lastname: Kryzhanovskiĭ
authors.forename: V P
authors.initials: VP
authors.lastname: Peresada
authors.forename: A M
authors.initials: AM
authors.lastname: Likhosherstov
authors.forename: S V
authors.initials: SV
authors.lastname: Revenko
authors.forename: N V
authors.initials: NV
authors.lastname: Kaverina
authors.forename: K M
authors.initials: KM
authors.lastname: Reznikov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D011719:Pyrazines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats
chemical_list: D000889:Anti-Arrhythmia Agents; D011719:Pyrazines