Utilization of macrophages in anticancer therapy: the macrophage network theory.
Appropriate and rational modulation of innate immunity may enhance the therapeutic efficacy of emerging immune therapies for treating cancer. One of the crucial cells of innate immunity is the macrophage. The purpose of this article was to review those issues that suggest ways of exploiting macrophage local functions in immune therapy, and to discuss the suitability of low molecular-weight lipopolysaccharides as potent modulators of macrophage functions for immune therapy of cancer.
Kohchi
Chie
C
Institute for Health Science, Tokushima Bunri University, Nishihama, Yamashiro-cho, Tokushima-shi, Japan.
Inagawa
Hiroyuki
H
Hino
Mami
M
Oda
Mutsumi
M
Nakata
Kazue
K
Yoshida
Aya
A
Hori
Hitoshi
H
Terada
Hiroshi
H
Makino
Kimiko
K
Takiguchi
Kunio
K
Soma
Gen-Ichiro
G
D000818:Animals; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*
D008070:Lipopolysaccharides