Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy.
Physical exercise and fitness programs in patients with epilepsy are still a matter of controversy. Effects of physical exercise in animals with epilepsy have been demonstrated. To further investigate the possible mechanisms by which physical activity interferes with epileptogenesis, the present work was aimed to study the effect of aerobic exercise on "in vitro" hippocampal electrophysiological parameters observed in rats submitted to the pilocarpine model of epilepsy. Electrophysiological changes were monitored by extracellular field potentials recorded from CA1 area. Control rats and rats with epilepsy were submitted to an aerobic exercise program. The number of population spikes (PS) and slope of field excitatory postsynaptic potentials (fEPSP) were analyzed. Trained rats with epilepsy exhibited a reduction in PS when compared with nontrained rats with epilepsy in different concentrations of extracellular potassium or bicuculline. Physical training also enhanced the late phase of LTP in rats with epilepsy. Our results indicate that physical training reduces CA1 hyperresponsiveness and can modify synaptic plasticity in rats submitted to the pilocarpine model of limbic epilepsy.
Arida
Ricardo Mario
RM
Laboratório de Neurologia Experimental, Universidade Federal de São Paulo-Escola Paulista de Medicina (UNIFESP/EPM), Rua Botucatú 862, Vila Clementino, CEP 04023-900 São Paulo, Brazil. arida.nexp@epm.br
Sanabria
Emilio Rafael Garrido
ER
da Silva
Andre Cesar
AC
Faria
Leonardo Coutinho
LC
Scorza
Fulvio Alexandre
FA
Cavalheiro
Esper Abrão
EA
D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D017774:Long-Term Potentiation; D018721:Muscarinic Agonists / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018721:Muscarinic Agonists; D010862:Pilocarpine