title: Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.
abstract: We report the first total synthesis of jiadifenin (1), the establishment of a modality for its biological evaluation, and the discovery of apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1.
authors.affiliation: Laboratory for Bioorganic Chemistry and Laboratory of Biochemistry and Pharmacology, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
authors.forename: Young Shin
authors.initials: YS
authors.lastname: Cho
authors.forename: David A
authors.initials: DA
authors.lastname: Carcache
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Li
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D000818:Animals; D009414:Nerve Growth Factors / Q000138:chemical synthesis / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D009414:Nerve Growth Factors; D012717:Sesquiterpenes; C457979:jiadifenin