title: [Synthesis and anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives].
abstract: OBJECTIVE
  To study the anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives.
  
  
  METHODS
  The target compounds were synthesized from p-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice.
  
  
  RESULTS
  Eleven compounds were obtained and confirmed by IR, 1HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity.
  
  
  CONCLUSIONS
  N-(4-arylamidophenyl) methanesulfonamide showed appreciable anti-inflammatory activity.
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Lou
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Dong
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Xu
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Ji
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004423:Ear / Q000473:pathology; D004427:Ear Diseases / Q000139:chemically induced / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014992:Xylenes
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D014992:Xylenes