Cell death promoted by homologous DNA interaction from bacteria to humans.
Pairing between homologous DNA controls cellular functions including double-strand break repair, mitotic recombination, and progression of DNA replication forks, as well as chiasma formation during meiosis. Here I summarize that homologous interaction could promote the cell killing in bacteria, yeast, and multicellular organisms. The mechanisms of cell killing are categorized into two types: (1) the killing due to the accumulation of extrachromosomal DNA; (2) the killing induced by Holliday junction structures. I propose that the mechanisms of such killing function as novel apoptotic pathways in the cells carrying severe DNA damages to eliminate such damages from cell population.
Kusano
Kohji
K
Department of Biological Functions and Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino (Research Park), Wakamatsu-ku, Kitakyushu 808-0196, Japan. kusano@life.kyutech.ac.jp
D000251:Adenosine Triphosphatases / Q000235:genetics; D017209:Apoptosis; D001419:Bacteria / Q000235:genetics; D018407:Bacterial Physiological Phenomena; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D004265:DNA Helicases / Q000235:genetics; D004260:DNA Repair; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D008957:Models, Genetic; D010957:Plasmids / Q000378:metabolism; D051135:Rad51 Recombinase; D053484:RecQ Helicases; D011995:Recombination, Genetic; D004718:Saccharomycetales; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D004268:DNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; D004247:DNA; C495153:RAD51 protein, human; D051135:Rad51 Recombinase; D000251:Adenosine Triphosphatases; C506725:RECQL protein, human; D004265:DNA Helicases; D053484:RecQ Helicases