title: Ancistroheynine B and two further 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus heyneanus Wall.
abstract: A new axially chiral naphthylisoquinoline alkaloid, ancistroheynine B (7), has been isolated from the leaves of the Indian liana Ancistrocladus heyneanus Wall., along with two known related alkaloids, ancistrocladidine (3) and ancistrotanzanine C (6), which are 7,3'-coupled, too. The structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Biological activities of ancistroheynine B against the pathogens of malaria, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated.
authors.affiliation: Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany. bringmann@chemie.uni-wuerzburg.de
authors.forename: Gerhard
authors.initials: G
authors.lastname: Bringmann
authors.forename: Michael
authors.initials: M
authors.lastname: Dreyer
authors.forename: Manuela
authors.initials: M
authors.lastname: Michel
authors.forename: Francis S K
authors.initials: FS
authors.lastname: Tayman
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification; D007546:Isoquinolines / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000302:isolation & purification; D009284:Naphthols / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D000981:Antiprotozoal Agents; D007546:Isoquinolines; D009281:Naphthalenes; D009284:Naphthols; C494932:ancistroheynine B; C486998:ancistrotanzanine C; C451486:ancistrocladidine