Role of postdose cyclosporine monitoring in living renal transplant recipients.
Achieving optimal cyclosporine (Neoral) absorption is critical for successful graft outcome. Recently there have been studies on postdose monitoring of cyclosporine. Two- and 3-hour postdose cyclosporine levels measured by radioimmunoassay were correlated with occurrence of rejection and cyclosporine nephrotoxicity in 30 patients; C(2) and C(3) levels were significantly lower than the desired therapeutic levels in patients with acute rejection. Based on our study and those of others we suggest C(3) levels should be adopted in clinical practice.
Thomas
R
R
Department of Transplant Surgery, Chandigarh, India.
Minz
M
M
Singh
B
B
Heer
M
M
Kashyap
R
R
D000208:Acute Disease; D001379:Azathioprine / Q000627:therapeutic use; D016572:Cyclosporine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D019520:Living Donors; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone; D001379:Azathioprine