Phosphorohydrazines of 4-oxo-4H-1-benzopyran and 1-benzopyran-2,4-dione exhibit antitumor activity against L1210 leukemia.
Phosphorohydrazines and phosphorohydrazones of benzopyran-2,4-dione as well as the phosphorohydrazone of 4-hydroxycoumarine were tested for antitumor activity in lymphatic leukemia L1210 bearing mice.
Nawrot-Modranka
J
J
Department of Bioinorganic Chemistry, Medical University, Lodz, Poland.
Ochocki
J
J
Graczyk
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
D000970:Antineoplastic Agents; D002867:Chromones; D006834:Hydrazines; D009943:Organophosphorus Compounds