title: Pulmonary alveolar proteinosis associated with psoriasis and complicated by mycobacterial infection: successful treatment with granulocyte-macrophage colony stimulating factor after a partial response to whole lung lavage.
abstract: Pulmonary alveolar proteinosis (PAP) is a rare lung disease. Although whole lung lavage is considered the most effective treatment, not every patient shows a complete response. The case ofa young man with PAP in association with psoriasis who underwent frequent whole lung lavage but only achieved remission following treatment with granulocyte-macrophage colony stimulating factor (GM-CSF) is reported. His lung problem was complicated by atypical mycobacterial infection,which resolved with treatment. The role of GM-CSF is discussed.
authors.affiliation: Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. alamine@pd.jaring.my
authors.forename: Jamalul Azizi
authors.initials: JA
authors.lastname: Abdul Rahman
authors.forename: Yuben P
authors.initials: YP
authors.lastname: Moodley
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Phillips
mesh_terms: D000328:Adult; D018893:Bronchoalveolar Lavage; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications*; D019909:Mycobacterium kansasii; D011565:Psoriasis / Q000150:complications*; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D012074:Remission Induction; D019233:Retreatment
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor