[The role of free radicals oxidation in the deterioration of haemovascular homeostasis in aging].
Torty-two practically healthy subjects aged 60-80 and twenty-seven their younger counterparts aged 20-29 were investigated. The study involved investigation of interrelation between functional state of the endothelium, erythrocytes, platelets, and the state of free radicals oxidation indices. The results obtained showed the activation of free radicals oxidation processes in the group of older and old subjects in the decrease of antioxidant defence activity, this fact being corroborated by a statistically significant increase in the content of plasma malone dialdehyde, low level of superoxide dismutase, and the lack of adequate increment in catalase and glutathione in response to the increase in peroxidation processes. Moreover in the group of healthy older and old people, a deterioration of vasomotor function of the endothelium, a rise in erythrocytes and platelets aggregation activity, an increase in blood viscosity at various shift velocities were detected. The results of correlative analysis testify to the existance of interrelation between the deterioration of the indices of functional state of haemovascular homeustasis and uncompensated free radicals oxidation activity.
Lishnevskaia
V Iu
VIu
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood* / Q000378:metabolism; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D001808:Blood Vessels / Q000378:metabolism; D001809:Blood Viscosity; D004730:Endothelium, Vascular / Q000201:enzymology / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D018056:Hemorheology; D006706:Homeostasis; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D010974:Platelet Aggregation; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D008315:Malondialdehyde; D013482:Superoxide Dismutase