title: Synthesis of polysubstituted 4-fluoroquinolinones.
abstract: [reaction: see text] A convenient one-pot synthesis of 4-fluoroquinolinones that are active against KDR kinase is described. The mechanism of the reaction is believed to involve the formation of a quinone methide intermediate.
authors.affiliation: Department of Chemistry, ImClone Systems, 180 Varick Street, 6th Floor, New York, New York 10014, USA.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Kiselyov
authors.forename: Evgueni L
authors.initials: EL
authors.lastname: Piatnitski
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Doody