title: Hemispherectomy procedures in children: haematological issues.
abstract: OBJECTIVE
  In literature, excessive perioperative haemorrhage and related haemodynamic instability have been described as major risk factors in hemispherectomy. In this report we analyse the impact of neurosurgical operation on both the haematological and coagulative patterns of these children, especially focusing on younger patients.
  
  
  METHODS
  From 1993 to 2003, 18 consecutive children suffering from intractable epilepsia and treated by hemispherectomy were admitted to the Pediatric Intensive Care Unit (PICU) of Catholic University Medical School, Policlinico Gemelli, Rome. Eight children had an entire hemisphere removed (anatomical hemispherectomy), whereas the remaining 10 underwent disconnective procedures (functional hemispherectomy) or cerebral cortex ablations (e.g. hemicorticectomy). Eleven out of these 18 children underwent hemispherectomy because of hemimegalencephaly (HME): their mean age was 14.5 months (range 3-56 months); non-HME patients underwent surgery for epileptogenic lesions involving the cerebral hemisphere to a great extent or diffusely. Data have been compared with an historical cohort of 13 children operated on before 1992 at the same institution comparable for age, aetiology of epilepsy and the modalities of surgical operation.
  
  
  CONCLUSIONS
  Blood losses and haemotransfusions showed a profound influence on the haematologic/coagulative status of the children operated upon. A strict correlation was demonstrated between estimated red cell volume (ERCV) loss and haemostatic impairment in this series. Recent surgical techniques appear to reduce blood losses and related haemocoagulative risks even in younger patients.
authors.affiliation: Paediatric Intensive Care Unit, Catholic University Medical School, 00168 Rome, Italy. xoct01@yahoo.it
authors.forename: M
authors.initials: M
authors.lastname: Piastra
authors.forename: D
authors.initials: D
authors.lastname: Pietrini
authors.forename: E
authors.initials: E
authors.lastname: Caresta
authors.forename: A
authors.initials: A
authors.lastname: Chiaretti
authors.forename: L
authors.initials: L
authors.lastname: Viola
authors.forename: F
authors.initials: F
authors.lastname: Cota
authors.forename: A
authors.initials: A
authors.lastname: Pusateri
authors.forename: G
authors.initials: G
authors.lastname: Polidori
authors.forename: C
authors.initials: C
authors.lastname: Di Rocco
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000503:physiopathology; D004827:Epilepsy / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D004906:Erythrocyte Count / Q000379:methods; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D038421:Hemispherectomy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011516:Prothrombin; D005340:Fibrinogen