title: [Administration of activated recombinant factor VII (novo seven) for the control of massive bleeding in gynecology].
abstract: We report our clinical opinion for recombinant activated factor VII (NovoSeven, Novo Nordisk, Copenhagen, Denmark) administration in gynecology patients with massive haemorrhage. 3 women with gynecology deseases and severe bleeding in recieved NovoSeven in bolus IV. The blood loss and laboratory changes in hematology and haemostasis parameters are monitored. The bleeding was ceased in all cases. Decrease in values of Hb, Er and PTT was noted. The use of recombinant factor VIIA in gynecology patients with severe bleeding is effective and safe enough and could be an alternative to the extreme surgical procedures.
authors.forename: S
authors.initials: S
authors.lastname: Tanchev
authors.forename: F
authors.initials: F
authors.lastname: Pandurski
authors.forename: A
authors.initials: A
authors.lastname: Georgiev
authors.forename: Iu
authors.initials: Iu
authors.lastname: Gesheva
authors.forename: V
authors.initials: V
authors.lastname: Platikanov
authors.forename: P
authors.initials: P
authors.lastname: Dinov
mesh_terms: D000328:Adult; D002648:Child; D005167:Factor VII / Q000008:administration & dosage / Q000627:therapeutic use*; D015942:Factor VIIa; D005260:Female; D005831:Genital Diseases, Female / Q000097:blood / Q000188:drug therapy*; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa