[Concomitant labyrinthitis].
The principal pathogenetic mechanism of labyrinthopaty development after traumas and operations lies in autoimmune inflammation of the contralateral ear similar to sympathetic inflammation of the eye. By analogy with sympathetic ophthalmitis, a term <<concomitant labyrinthitis>> is proposed. Due to selective permeability of selective membranes, immune system has no connection with <<extrabarrier>> organs. These organs and tissues are isolated from the key sourse of immunity -- blood. Autotolerance to them is absent and their proteins are autoantigens. In destruction of hemato-labyrinthine barrier these autoantigens can reach lymphoid organs and provoke immune response inducing a cytotoxic action in relation to both the affected and the contralateral labyrinth. Besides pathology of the affected labyrinth, clinical picture of labyrinthopathy is caused by autoimmune labyrinthitis of the contralateral ear whereas in <<dead>> labyrinthitis of the affected ear - slow-progressive autoimmune concomitant labyrinthitis. Case reports are presented.
Nugumanov
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D000328:Adult; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology; D003638:Deafness / Q000209:etiology; D004244:Dizziness / Q000209:etiology; D005260:Female; D034381:Hearing Loss / Q000209:etiology; D006801:Humans; D007762:Labyrinthitis / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014012:Tinnitus / Q000209:etiology; D016896:Treatment Outcome
D001324:Autoantigens