title: Oxaspirodion, a new inhibitor of inducible TNF-alpha expression from the Ascomycete chaetomium subspirale. Production, isolation and structure elucidation.
abstract: In a search for new inhibitors of the TNF-alpha promoter activity, a new spiro-compound, designated oxaspirodion, was obtained as a mixture of four isomers from fermentations of the ascomycete Chaetomium subspirale. The structure was determined by a combination of spectroscopic techniques.
authors.affiliation: Institut für Biotechnologie und Wirkstoff-Forschung e. V., Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Rether
authors.forename: Gerhard
authors.initials: G
authors.lastname: Erkel
authors.forename: Timm
authors.initials: T
authors.lastname: Anke
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
mesh_terms: D002597:Chaetomium / Q000378:metabolism*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011401:Promoter Regions, Genetic / Q000187:drug effects*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000235:genetics*
chemical_list: D005663:Furans; D013141:Spiro Compounds; D014409:Tumor Necrosis Factor-alpha; C493110:oxaspirodion