Mucosal administration of flagellin induces innate immunity in the mouse lung.
Nonsurgical intratracheal instillation of 1 microg of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1alpha, and MIP-2.
Honko
Anna N
AN
Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Mizel
Steven B
SB
D000818:Animals; D054407:Chemokine CCL4; D054426:Chemokine CXCL2; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005408:Flagellin / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D006090:Gram-Negative Bacteria / Q000276:immunology*; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D007113:Immunity, Innate; D015850:Interleukin-6 / Q000378:metabolism; D008168:Lung / Q000276:immunology*; D019402:Macrophage Inflammatory Proteins / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D015846:Monokines / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology; D012477:Salmonella enteritidis / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D054407:Chemokine CCL4; D054426:Chemokine CXCL2; D016207:Cytokines; D015850:Interleukin-6; D019402:Macrophage Inflammatory Proteins; D015846:Monokines; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D005408:Flagellin; D016179:Granulocyte Colony-Stimulating Factor