title: Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin.
abstract: In frog skin, tachykinins stimulate the ion transport, estimated by measuring the short-circuit current (SCC) value, by interacting with NK1-like receptors. In this paper we show that Kassinin (NK2 preferring in mammals) increases the SCC, while Enterokassinin has no effect. Therefore, either 2 Pro residues or 1 Pro and 1 basic amino acid must be present in the part exceeding the C-terminal pentapeptide. Eledoisin (NK3 preferring in mammals) stimulation of SCC is reduced by CP99994 and SR48968 (NK1 and NK2 antagonists) and not affected by SB222200 (NK3 antagonist). None of the three antagonists affects Kassinin stimulation of SCC.
authors.affiliation: Dipartimento di Fisiologia Generale ed Ambientale, Università di Bari, Via Amendola 165/A, 70126 Bari, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Lippe
authors.forename: Vito
authors.initials: V
authors.lastname: Bellantuono
authors.forename: Concetta
authors.initials: C
authors.lastname: Ardizzone
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cassano
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D004600:Eledoisin / Q000378:metabolism / Q000494:pharmacology*; D017136:Ion Transport / Q000502:physiology*; D015286:Kassinin / Q000378:metabolism / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D011893:Rana esculenta / Q000502:physiology*; D012867:Skin / Q000378:metabolism*; D012879:Skin Physiological Phenomena / Q000187:drug effects; D013237:Stereoisomerism; D015320:Tachykinins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001549:Benzamides; D010880:Piperidines; D011804:Quinolines; C109112:SB 222200; D015320:Tachykinins; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; D015286:Kassinin; D004600:Eledoisin; C073839:SR 48968