title: Unusual location of eosinophilic granuloma.
abstract: Eosinophilic granuloma EG is a benign self-limiting disease, which belongs to the spectrum of Langerhans' cell histiocytosis LCH. The etiology of LCH remains unknown, although the evidence indicates that it is a clonal proliferative disorder of Langerhans cells, it has also been characterized as reactive disorder, neoplastic process and a berrant immune response. Eosinophilic granuloma is characterized by single or multiple skeletal lesions occurring predominately in children, adolescents and young adults, it accounts for 70% of LCH. It is more common in males, and the common sites are the skull, mandible, ribs, spines and long bones particularly the femur and the humerus. The estimated incidence of EG is 3-4 per million of the population. Vertebral bone involvement is rarely seen and usually affects the vertebral body. We are reporting an unusual case of EG in a female child presented with a solitary lesion at posterior element of lumbar vertebra.
authors.affiliation: Department of Radiology , Madina Maternity and Children's Hospital, Madina Al-Munawara, Kingdom of Saudi Arabia.
authors.forename: Ammar S
authors.initials: AS
authors.lastname: Haouimi
authors.forename: Zakaria M
authors.initials: ZM
authors.lastname: Al-Hawsawi
authors.forename: Ahmed N
authors.initials: AN
authors.lastname: Jameel
mesh_terms: D001707:Biopsy, Needle; D016025:Bone Transplantation / Q000379:methods; D002648:Child; D003131:Combined Modality Therapy; D003475:Curettage / Q000379:methods; D004803:Eosinophilic Granuloma / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D017116:Low Back Pain / Q000175:diagnosis / Q000209:etiology; D008159:Lumbar Vertebrae / Q000473:pathology* / Q000601:surgery; D018570:Risk Assessment; D012720:Severity of Illness Index; D013122:Spinal Diseases / Q000175:diagnosis* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome