title: Sagliker syndrome: uglifying human face appearance in late and severe secondary hyperparathyroidism in chronic renal failure.
abstract: Almost every patient with chronic renal failure (CRF) eventually develops secondary hyperparathyroidism (SH) unless they are treated with proper and novel medications in advanced medical centers by skilled medical personnel. Every kind of bone abnormality including skull deformities has been described in detail by almost every concerned researcher and textbook, but descriptions of this phenomenon are limited in the medical literature to the years from 1973 to 1977. To our knowledge, extensive data regarding uglifying human face appearances have not been defined so far in the literature. We are therefore making this addition to the clinical nephrology field by accumulating such data. After we found 2 consecutive peculiar and unique patients with uglifying human face appearances in 2000, we attempted to inform and draw attention to this new entity to all hemodialysis (HD) centers in Turkey, as well as in other developing countries around the world to collect data on this phenomenon. Accordingly, we visited dialysis centers and patients' houses to collect detailed information, including medical clinical histories, physical examinations, laboratory data, biographies, current medications, and so forth. We found 25 patients who had CRF, SH, short stature, extremely severe skull changes, maxillary and mandibular bone changes, teeth/dental abnormalities, and soft and innocuous tumoral tissues in the mouth (hence, uglifying the appearance of the face), fingertip changes, severe psychologic problems, and depression. It appears that patients with CRF may have a new syndrome of bone deformities that have long been neglected, ignored, and forgotten since the mid-1970s when they were first described. This is vital and critical information for the clinical status of patients who suffered from the syndrome that we have named Sagliker syndrome (SS), and we believe there are many more patients in the world who are suffering from it.
authors.affiliation: Cukurova University Medical Faculty, Adana, Turkey. sagerya@superonline.com
authors.forename: Yahya
authors.initials: Y
authors.lastname: Sagliker
authors.forename: Mustafa
authors.initials: M
authors.lastname: Balal
authors.forename: Piril
authors.initials: P
authors.lastname: Sagliker Ozkaynak
authors.forename: Saime
authors.initials: S
authors.lastname: Paydas
authors.forename: Cemal
authors.initials: C
authors.lastname: Sagliker
authors.forename: Hasan
authors.initials: H
authors.lastname: Sabit Sagliker
authors.forename: Necati
authors.initials: N
authors.lastname: Kiralp
authors.forename: Siddik
authors.initials: S
authors.lastname: Mumin Adam
authors.forename: Ilhan
authors.initials: I
authors.lastname: Tuncer
authors.forename: Gulfiliz
authors.initials: G
authors.lastname: Gonlusen
authors.forename: Mustafa
authors.initials: M
authors.lastname: Esenturk
authors.forename: Erdal
authors.initials: E
authors.lastname: Gocmez
authors.forename: Hulya
authors.initials: H
authors.lastname: Taskapan
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yeksan
authors.forename: Ersin
authors.initials: E
authors.lastname: Kobaner
authors.forename: Ozan
authors.initials: O
authors.lastname: Ozkaya
authors.forename: Musa
authors.initials: M
authors.lastname: Yuksekgonul
authors.forename: Idris
authors.initials: I
authors.lastname: Emir
authors.forename: Nurdan
authors.initials: N
authors.lastname: Cengiz
authors.forename: Ismet
authors.initials: I
authors.lastname: Onder Isik
authors.forename: Omer
authors.initials: O
authors.lastname: Bilginer
authors.forename: Turgay
authors.initials: T
authors.lastname: Guler
authors.forename: Hasan
authors.initials: H
authors.lastname: Yakar
authors.forename: Nedim
authors.initials: N
authors.lastname: Sarsmaz
authors.forename: Serkan
authors.initials: S
authors.lastname: Dilaver
authors.forename: Balim
authors.initials: B
authors.lastname: Akoglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Basgumus
authors.forename: Ercin
authors.initials: E
authors.lastname: Chirik
mesh_terms: D000015:Abnormalities, Multiple; D000367:Age Factors; D002648:Child; D005145:Face / Q000002:abnormalities*; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D012720:Severity of Illness Index; D013577:Syndrome