title: Antiplaque and antigingivitis efficacy of toothpastes containing Triclosan and fluoride.
abstract: OBJECTIVE
  To compare the reduction of plaque and gingivitis from the following three toothpaste formulations containing: 0.3% Triclosan, 1,000ppm fluoride and 0.13% calcium glycerophosphate in a natural calcium carbonate base (a new paste); 0.2% Triclosan and 1,000ppm fluoride in a precipitated calcium carbonate base; 0.3% Triclosan, 1,000ppm fluoride and Gantrez in a silica base. A control group was maintained, which used commercially available toothpastes without the above actives.
  
  
  METHODS
  A double-blind, four-cell, stratified, parallel group design study. Subjects brushed twice daily with their allocated toothpaste for 12 weeks. Plaque, MGI and gingival bleeding assessments were carried out at baseline, after 6 and 12 weeks of product use.
  
  
  CONCLUSIONS
  An analysis of covariance of the 12-week results showed significant differences between products [p<0.0001] for plaque, MGI and gingival bleeding. The new toothpaste formulation containing 0.3% Triclosan, 1,000ppm fluoride and 0.13% calcium glycerophosphate in a natural calcium carbonate base was shown to be significantly more effective in reducing plaque and gingivitis than the other toothpaste formulations in the study.
authors.affiliation: Manipal College of Dental Sciences, Mangalore, Karnataka, India. sobenpeter@yahoo.co.in
authors.forename: S
authors.initials: S
authors.lastname: Peter
authors.forename: D G
authors.initials: DG
authors.lastname: Nayak
authors.forename: P
authors.initials: P
authors.lastname: Philip
authors.forename: N S
authors.initials: NS
authors.lastname: Bijlani
mesh_terms: D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000008:administration & dosage; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control*; D005994:Glycerophosphates / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D010512:Periodontal Index; D012822:Silicon Dioxide / Q000008:administration & dosage; D014099:Toothbrushing; D014100:Toothpastes / Q000627:therapeutic use*; D016896:Treatment Outcome; D014260:Triclosan / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D005994:Glycerophosphates; D014100:Toothpastes; D014260:Triclosan; D012822:Silicon Dioxide; D002119:Calcium Carbonate; D005459:Fluorides