title: What antepartum fetal test should guide the timing of delivery of the preterm growth-restricted fetus? A decision-analysis.
abstract: OBJECTIVE
  The purpose of this study was to use a decision-analytic approach to explore the best strategy for the timing of the delivery of preterm intrauterine growth-restricted fetuses.
  
  
  METHODS
  We constructed a decision-analysis model that compared 4 antenatal fetal testing strategies The fetal/neonatal states that were compared included live in utero pregnancy; fetal death; neonatal death; disabled neonate, and healthy neonate. Probability estimates for these states and sensitivity and specificity for Doppler velocimetry and biophysical profile were derived from literature review. Sensitivity analyses were performed on the baseline assumptions.
  
  
  RESULTS
  Under the baseline assumptions, biophysical profile was the best test to guide decisions on delivery. Sensitivity analyses revealed the model to be sensitive only to the specificity of a biophysical profile <82%.
  
  
  CONCLUSIONS
  Compared with the other options, biophysical profile was the best strategy to guide physicians on the timing of the delivery of the preterm growth-restricted fetus.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, University of Pennsylvania Medical Center, 3400 Spruce Street, 2000 Ravdin Courtyard, Philadelphia, PA 19104, USA. aodibo@mail.obgyn.upenn.edu
authors.forename: Anthony O
authors.initials: AO
authors.lastname: Odibo
authors.forename: Joanne N
authors.initials: JN
authors.lastname: Quinones
authors.forename: Kirsten
authors.initials: K
authors.lastname: Lawrence-Cleary
authors.forename: David M
authors.initials: DM
authors.lastname: Stamilio
authors.forename: George A
authors.initials: GA
authors.lastname: Macones
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D003661:Decision Support Techniques; D036861:Delivery, Obstetric; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D017078:Laser-Doppler Flowmetry; D011247:Pregnancy; D011336:Probability; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013997:Time Factors; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal