Anti-inflammatory and anti-nociceptive activity of the water decoction Desmodium gangeticum.
The water decoction of root and aerial parts of Desmodium gangeticum (Leguminosae) was examined for anti-inflammatory and anti-nociceptive activity in experimental animals. The root and aerial decoction in doses of 5, 10 and 20 mg /kg caused a dose-dependent inhibition of swelling caused by carrageenin equivalent to 14.58-51.02% protection and 14.43-38.67%, respectively, in cotton pellet granuloma. There was a significant increase in analgesio-meter-induced force equivalent to 6.56-67.66% protection and 22.18-73.83% protection in acetic acid-induced writhing. The result establishes the traditional use of water decoction of Desmodium gangeticum codified in Indian System of Medicine.
Rathi
Anshu
A
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute (Council of Scientific and Industrial Research), Rana Pratap Marg, Post Box No. 436, Lucknow 226 001, Uttar Pradesh, India. rathi_anshu@yahoo.com
Rao
Ch V
ChV
Ravishankar
B
B
De
S
S
Mehrotra
S
S
D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D007887:Fabaceae; D005260:Female; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D014867:Water
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D014867:Water