title: Antibiotics for preterm rupture of the membranes: a systematic review.
abstract: OBJECTIVE
  We sought to evaluate the administration of antibiotics to pregnant women with preterm rupture of membranes (PROM).
  
  
  METHODS
  We collected data by using the Cochrane Controlled Trials Register and MEDLINE.
  
  
  METHODS
  We included randomized controlled comparisons of antibiotic versus placebo (14 trials, 6,559 women).
  
  
  RESULTS
  Antibiotics were associated with a statistically significant reduction in maternal infection and chorioamnionitis. There also was a reduction in the number of infants born within 48 hours and 7 days and with the following morbidities: neonatal infection (relative risk [RR] 0.67, 95% confidence interval [CI] 0.52-0.85), positive blood culture (RR 0.75, 95% CI 0.60-0.93), use of surfactant (RR 0.83 95% CI 0.72-0.96), oxygen therapy (RR 0.88, 95% CI 0.81-0.96), and abnormal cerebral ultrasound scan before discharge from hospital (RR 0.82, 95% CI 0.68-0.99). Perinatal mortality was not significantly reduced (RR 0.91, 95% CI 0.75-1.11). A benefit was present both in trials where penicillins and erythromycin were used. Amoxicillin/clavulanate was associated with a highly significant increase in the risk of necrotizing enterocolitis (RR 4.60, 95% CI 1.98-10.72).
  
  
  CONCLUSIONS
  The administration of antibiotics after PROM is associated with a delay in delivery and a reduction in maternal and neonatal morbidity. These data support the routine use of antibiotics for women with PROM. Penicillins and erythromycin were associated with similar benefits, but erythromycin was used in larger trials and, thus, the results are more robust. Amoxicillin/clavulanate should be avoided in women at risk of preterm delivery because of the increased risk of neonatal necrotizing enterocolitis. Antibiotic administration after PROM is beneficial for both women and neonates.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Leicester, United Kingdom.
authors.forename: Sara
authors.initials: S
authors.lastname: Kenyon
authors.forename: Michel
authors.initials: M
authors.lastname: Boulvain
authors.forename: Jim
authors.initials: J
authors.lastname: Neilson
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D020345:Enterocolitis, Necrotizing / Q000209:etiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D009017:Morbidity; D010406:Penicillins / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D000658:Amoxicillin