title: Thrombophilic polymorphisms--factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations--and preterm birth.
abstract: OBJECTIVE
  To evaluate the influence of three common thrombophilic polymorphisms, factor V Leiden (FV), prothrombin G20210A (PT), and methylenetetrahydrofolate reductase (MTHFR) C677T mutations, on preterm birth of unknown cause.
  
  
  METHODS
  A single-centre case-control study of women with preterm infants < or =35 weeks of gestation, in whom obvious maternal, uterine, and fetal causes responsible for preterm birth were excluded (n = 35). The controls were 54 women with term infants hospitalised in the same ward.
  
  
  RESULTS
  There were no significant differences between the groups of mothers in history of fetal loss, venous or familial thrombosis, or previous preterm birth. FV was found in 8.6% of the cases, PT in 5.7%, and MTHFR mutation (homozygous) in 4.8% compared with 5.4% (p=0.292, OR 1.594, CI95% 0.303-8.384), 7.4% (p=0.379, OR 0.758, CI95% 0.131-4.374), and 4.5% (p = 0.485, OR 1.050, CI95% 0.090-12.276), respectively, in the controls. Differences in the three thrombophilic polymorphisms in the two groups of infants were also not significant.
  
  
  CONCLUSIONS
  We could not demonstrate a distinct association between these thrombophilic polymorphisms and preterm birth.
authors.affiliation: Department of Pediatrics, University Hospital Graz, Graz, Austria. bernhard.resch@meduni-graz.at
authors.forename: Bernhard
authors.initials: B
authors.lastname: Resch
authors.forename: Siegfried
authors.initials: S
authors.lastname: Gallistl
authors.forename: Jörg
authors.initials: J
authors.lastname: Kutschera
authors.forename: Christine
authors.initials: C
authors.lastname: Mannhalter
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Muntean
authors.forename: Wilhelm D
authors.initials: WD
authors.lastname: Mueller
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D005865:Gestational Age; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D008423:Maternal Age; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)