The ubiquitous phosphoinositides.
There are now known to exist seven phosphoinositides all derived through various metabolic routes from the parent lipid phosphatidylinositol. With one additional metabolite, diacylglycerol, these represent a rich resource of bioactive lipids responsible for recruiting protein effectors and marking membrane compartments. The metabolic map of this pathway and the nature of the binding partner interactions are reviewed.
Parker
P J
PJ
Protein Phosphorylation Laboratory, London Research Institute CRUK, 44 Lincoln's Inn Fields, London EC2A 3PX, UK. Peter.Parker@cancer.org.uk
D000818:Animals; D004075:Diglycerides / Q000378:metabolism; D008954:Models, Biological; D010716:Phosphatidylinositols / Q000378:metabolism*; D015398:Signal Transduction
D004075:Diglycerides; D010716:Phosphatidylinositols