title: [The expression profiles of human chromosome 21 orthologues in mouse M II oocyte].
abstract: OBJECTIVE
  To analyse the expression profile of orthologues of human chromosome 21 (HC21) in mouse M II oocytes, and to discuss the relationship between this expression profile and early embryonic development and further to find the possible reasons of DS phenotypes genesis.
  
  
  METHODS
  cDNA array and Global RT-PCR methods were used to analyse and identify the expression profile of 93 HC21 orthologues in mouse M II oocytes.
  
  
  RESULTS
  26 of 93 orthologues were proved to be expressed in mouse M II oocytes and these genes were involved in many biological procedure including transcriptional, metabolism, ionic channel, and ubiquitin pathway etc.
  
  
  CONCLUSIONS
  To our knowledge, this is first report about the HC21 orthologues expression profile in M II oocytes and this expression profile indicates that 26 of 93 HC21 orthologues may directly play important role in early development, and the biological information obtained from this experiment would be beneficial to understand imbalance of HC21 genes expression and the molecular mechanism of DS phenotypes genesis.
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Yu
authors.forename: Rong
authors.initials: R
authors.lastname: Liang
authors.forename: Huan
authors.initials: H
authors.lastname: Shen
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Yang
authors.forename: Jing-Zhu
authors.initials: JZ
authors.lastname: Guo
mesh_terms: D000818:Animals; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D004314:Down Syndrome / Q000235:genetics* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D005796:Genes / Q000235:genetics; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009865:Oocytes / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D010641:Phenotype; D016372:RNA, Antisense / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D026801:Synteny; D014158:Transcription, Genetic
chemical_list: D016372:RNA, Antisense