title: Clobetasol propionate lotion in the treatment of moderate to severe plaque-type psoriasis.
abstract: Owing to its anti-inflammatory, antipruritic, vasoconstrictive, and immune-modulating properties, clobetasol propionate is used to treat psoriasis. This study was conducted to evaluate the efficacy, safety, and cosmetic acceptability of clobetasol propionate lotion compared with its vehicle and with clobetasol propionate cream in the treatment of moderate to severe plaque-type psoriasis. A total of 222 patients were treated. After 4 weeks of treatment, clobetasol propionate lotion was more efficient than vehicle lotion and of equivalent efficacy as clobetasol propionate cream. Cosmetic acceptability was significantly better with clobetasol propionate lotion than with clobetasol propionate cream. Clobetasol propionate lotion was efficient, safe, and well tolerated and offers a significantly higher cosmetic advantage in the treatment of moderate to severe plaque-type psoriasis compared with clobetasol propionate cream.
authors.affiliation: Department of Dermatology and Venereology, Alexander's University Hospital, Sofia, Bulgaria.
authors.forename: Jacques
authors.initials: J
authors.lastname: Decroix
authors.forename: Henrik
authors.initials: H
authors.lastname: Pres
authors.forename: Nicola
authors.initials: N
authors.lastname: Tsankov
authors.forename: Michel
authors.initials: M
authors.lastname: Poncet
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Arsonnaud
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002990:Clobetasol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013684:Telangiectasis / Q000139:chemically induced; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D002990:Clobetasol