Synthesis, characterization and antimicrobial activity of 1,5-bis[2-(hydroximino)-1-methyl-3-oxo-butane-1,1-diyl]thiocarbonohydrazide and 1,5-bis[2-(hydroximino) -3-oxo-1-phenyl-butane-1,1-diyl]thiocarbonohydrazide.
1,5-Bis[2-(hydroximino)-1-methyl-3-oxo-butane-1,1-diyl]thiocarbonohydrazide [IV] and 1,5-bis[2-(hydroximino)-3-oxo-1-phenyl-butane-1,1-diyl]thiocarbonohydrazide [V] were synthesized by the reaction of thiocarbonohydrazide [I] with either 3-(hydroximino)-pentane-2,4-dione [II] or 2-(hydroximino)-1-phenyl-butane-1,3-dione [III] in a 1:2 molar proportion, respectively. Compounds [IV] and [V] were characterized by elemental analyses, IR and PMR spectroscopic studies. These newly synthesized compounds have been screened or their antimicrobial activity against S. aureus, S. typhi. C. albicans, T. mentagrophytes, T. rubrum and M. tuberculosis.
Patil
Meenakshi V
MV
Department of Chemistry, The Institute of Science, Mumbai, India.
Malve
Sheela P
SP
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D006834:Hydrazines / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data
D000900:Anti-Bacterial Agents; D006834:Hydrazines; C011368:thiocarbohydrazide