title: [Pulmonary hypertension: the issues of diagnosis and treatment].
abstract: Pulmonary hypertension is not a rare pathology that is met in a doctor's practice. It has been defined as a mean pulmonary artery pressure >25 mmHg at rest or >30 mmHg at exercise, or by a systolic pulmonary artery pressure >40 mmHg measured by echo-Doppler. The article analyzes pulmonary arterial hypertension, especially primary one, and its classification, diagnosis, and possibilities for medication. The major role in pathogenesis is ascribed for in situ thrombosis, intimal and adventitial proliferation and smooth muscle hypertrophy. Prostacyclin analogues, nitric oxide, calcium channel blockers and endothelin-1 receptor blockers are the most important medicines, which decrease pressure in the pulmonary artery. The clinical case of the 63-year-old woman, who was ill with severe primary pulmonary arterial hypertension, is described in the article.
authors.affiliation: Clinic of Pulmonology and Immunology, Kaunas University of Medicine Hospital, Lithuania. 0917@one.lt
authors.forename: Raimundas
authors.initials: R
authors.lastname: Sakalauskas
authors.forename: Diana
authors.initials: D
authors.lastname: Barkauskiene
authors.forename: Jolita
authors.initials: J
authors.lastname: Vebriene
authors.forename: Saulius
authors.initials: S
authors.lastname: Sadauskas
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use; D004562:Electrocardiography; D011464:Epoprostenol / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000145:classification / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality; D016285:Iloprost / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D013902:Radiography, Thoracic; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013997:Time Factors; D018608:Ultrasonography, Doppler; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D001993:Bronchodilator Agents; D002121:Calcium Channel Blockers; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D009569:Nitric Oxide; D011464:Epoprostenol; D016285:Iloprost