Intrathecal morphine, but not buprenorphine or pentazocine, can induce spastic paraparesis after a noninjurious interval of spinal cord ischemia in the rat.
In this study, we sought to determine the effect of intrathecal (IT) pentazocine or buprenorphine on the neurological outcome after a short interval of spinal cord ischemia in rats. Although IT morphine (30 microg) induced spastic paraparesis after 6 min of aortic occlusion, neither pentazocine (150 microg) nor buprenorphine (4 microg) produced neurological dysfunction. Our results indicate that the effect of various opioids on the motor function after a noninjurious interval of spinal cord ischemia is opioid-specific.
Nakamura
Seiya
S
Department of Anesthesiology, University of the Ryukyus, Okinawa, Japan.
Kakinohana
Manabu
M
Sugahara
Kazuhiro
K
Kinjo
Sakura
S
Miyata
Yuji
Y
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002047:Buprenorphine / Q000008:administration & dosage / Q000633:toxicity*; D007278:Injections, Spinal; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000633:toxicity*; D018908:Muscle Weakness / Q000139:chemically induced; D020335:Paraparesis / Q000139:chemically induced* / Q000503:physiopathology; D010423:Pentazocine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000473:pathology; D020760:Spinal Cord Ischemia / Q000150:complications / Q000503:physiopathology*
D000701:Analgesics, Opioid; D002047:Buprenorphine; D009020:Morphine; D010423:Pentazocine