title: Antimicrobial and antileishmanial activities of hypocrellins A and B.
abstract: Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.
authors.affiliation: The National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Guoyi
authors.initials: G
authors.lastname: Ma
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Jacob
authors.forename: Babu L
authors.initials: BL
authors.lastname: Tekwani
authors.forename: Zuqiang
authors.initials: Z
authors.lastname: Li
authors.forename: David S
authors.initials: DS
authors.lastname: Pasco
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007893:Leishmania donovani / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009894:Opportunistic Infections / Q000382:microbiology; D010569:Perylene / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019800:Phenol; D011809:Quinones / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D011809:Quinones; D019800:Phenol; D010569:Perylene; C048388:hypocrellin A; C064522:hypocrellin B