Seminal fluid enhances replication of human T-cell leukemia virus type 1: implications for sexual transmission.
Seminal fluid enhanced human T-cell leukemia virus type 1 (HTLV-1) infection by transactivating the HTLV-1 long terminal repeat promoter, which is chromosomally integrated in a cell-type-dependent manner. Our data may indicate a potential role for seminal fluid in the sexual transmission of HTLV-1 and imply complex features of regulation of HTLV-1 expression.
Moriuchi
Masako
M
Department of Pediatrics, Nagasaki University Hospital, Nagasaki 852-8501, Japan.
Moriuchi
Hiroyuki
H
D015490:HTLV-I Infections / Q000635:transmission*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D012661:Semen / Q000502:physiology*; D012749:Sexually Transmitted Diseases / Q000209:etiology*; D020079:Terminal Repeat Sequences; D014779:Virus Replication