title: Neuropathology: many paths lead to hereditary spastic paraplegia.
abstract: Studies with animal models are providing new insights into the pathology of hereditary spastic paraplegia, particularly how mutations in multiple, converging pathways can lead to this family of neuropathies.
authors.affiliation: Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Gould
authors.forename: Scott T
authors.initials: ST
authors.lastname: Brady
mesh_terms: D006801:Humans; D000251:Adenosine Triphosphatases / Q000378:metabolism; D001369:Axons / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D015419:Spastic Paraplegia, Hereditary / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000074181:Spastin; D013572:Synaptic Vesicles / Q000378:metabolism
chemical_list: D000251:Adenosine Triphosphatases; D009185:Myelin Proteins; C400283:SPAST protein, human; D000074181:Spastin