[Multi-drug resistant Mycobacterium leprae from patients with leprosy].
DNA sequences of Mycobacterium leprae in particular regions of the gyrA, rpoB, and folP genes responsible for resistance to new quinolones, rifampicin and dapsone, respectively, were analyzed. Among 88 isolates of M. leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines, eleven isolates had mutational changes in 2 genes (resistance to 2 drugs), and 2 isolates (Shinsei-1 and Zensho-4) showed mutations in 3 genes (resistance to 3 drugs). These findings are suggesting emergence of multi-drug resistant M. leprae.
Maeda
Shinji
S
Department of Host Defense, Osaka City University Graduate School of Medicine, Japan. smaeda@med.osaka-cu.ac.jp
D000818:Animals; D001483:Base Sequence / Q000235:genetics; D027081:DNA Gyrase / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D003622:Dapsone / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000235:genetics*; D006801:Humans; D007917:Leprostatic Agents / Q000494:pharmacology*; D007918:Leprosy / Q000382:microbiology*; D009154:Mutation; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000235:genetics*; D015242:Ofloxacin / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology
D007917:Leprostatic Agents; D003622:Dapsone; D015242:Ofloxacin; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit; D027081:DNA Gyrase; D012293:Rifampin