Spinal cord compression and lung metastasis of Wilms' tumor in a pregnant adolescent.
Wilms' tumor in adults is rare, and no treatment guidelines have been established. Spinal cord compression has also been rarely reported in all age groups. In this case report, we present a 19-year-old adolescent with recurrent Wilms' tumor, a paraspinal dumbbell mass, metastatic involvement of the vertebral bodies, lung metastasis, and pregnancy. To our knowledge, this is the first report of a pregnant patient with Wilms' tumor who had to undergo immediate chemotherapy with vincristine and actinomycin-D owing to spinal cord compression at 25 weeks of pregnancy. After delivery, complete remission was maintained with a regimen of ifosfamide, carboplatin, and etoposide and vincristine, actinomycin-D, and cyclophosphamide. No teratogenic or other toxic effects of vincristine or actinomycin-D were observed in the fetus.
Corapcioglu
Funda
F
Department of Pediatric Oncology, Kocaeli University, Izmit-Kocaeli, Turkey.
Dillioğlugil
Ozdal
O
Sarper
Nazan
N
Akansel
Gür
G
Calişkan
Muhittin
M
Arisoy
A Engin
AE
D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D003907:Dexamethasone / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000150:complications* / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D008159:Lumbar Vertebrae; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010352:Patient Dropouts; D011128:Polyradiculopathy / Q000209:etiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D012074:Remission Induction; D013117:Spinal Cord Compression / Q000209:etiology*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects; D009396:Wilms Tumor / Q000150:complications* / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery
D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003907:Dexamethasone; D003520:Cyclophosphamide; D016190:Carboplatin; D007069:Ifosfamide