title: Effects of early nutrition intervention on IGF1, IGFBP3, intestinal development, and catch-up growth of intrauterine growth retardation rats.
abstract: OBJECTIVE
  To investigate the effects of early nutritional intervention on the serum insulin-like growth factor-1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), intestinal development, and catch-up growth of intrauterine growth retardation (IUGR) rats by giving the IUGR new born rats different protein level diet.
  
  
  METHODS
  IUGR rat model was built by starvation of pregnant female rats. Twenty-four IUGR pups and 8 normal pups were divided randomly into 4 groups: normal control group (C group); IUGR control group (S group), IUGR low-protein diet group (SL group), and IUGR high-protein diet group (SH group). Detected the serum IGF1, IGFBP3, body weight, body length, intestinal weight length, intestinal villi height (VH), crypt depth (CD), villi absorbing area (VSA), mucous thickness (MT), and disaccharidase at the 4th week.
  
  
  RESULTS
  (1) The SH group showed the fastest catch-up growth, serum IGF1, IGFBP3, VH, and VSA were significantly higher than those of normal control group and IUGR control group. The intestinal weight and length, and the activities of lactase and saccharase of the SH group also reached the normal control group level. (2) The SL group kept on small size, the serum IGF1, IGFBP3, and most of intestinal histological indexes were all significantly lower than other groups. (3) IGF1, IGFBP3 were positively correlated to intestinal VH, VSA, saccharase, body weight and length.
  
  
  CONCLUSIONS
  The serum IGF1 was a sensitive index to the catch-up growth. The early nutritional intervention of high-protein diet after birth is helpful for the catch-up growth of IUGR through promoting the intestinal development and the absorption of nutrition.
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080.
authors.forename: Xiao-shan
authors.initials: XS
authors.lastname: Qiu
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Huang
authors.forename: Hui-ying
authors.initials: HY
authors.lastname: Deng
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Shen
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Ke
authors.forename: Kai-yong
authors.initials: KY
authors.lastname: Mei
authors.forename: Feng
authors.initials: F
authors.lastname: Lai
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001835:Body Weight / Q000187:drug effects; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000209:etiology; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007422:Intestines / Q000254:growth & development / Q000473:pathology; D009747:Nutritional Physiological Phenomena; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004044:Dietary Proteins; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I