[Histoculture drug response assay for solitary fibrous tumor--a case report].
A 49-year-old male was referred to our hospital because of an abnormal shadow in his left lower lung field on chest X-ray. Magnetic resonance imaging scans revealed a large mass on the left diaphragm. The tumor was surgically extirpated. The tumor, encapsulated and growing from the center of the left diaphragm, measured 18 x 8 x 4 cm and weighed 440 g. Microscopic examination revealed a solitary fibrous tumor with mitotic activity of 7/ 50 hpf. Immunohistochemically, the tumor was negative for cytokeratin, s-100 protein, desmin, and alpha-smooth muscle actin, while positive for vimentin and CD34. On a histoculture drug response assay using the resected tissue, the tumor was sensitive to 5-FU, adriamycin, mitomycin C and docetaxel, and resistant to cisplatin, irinotecan, and gemcitabine.
Yoshimasu
Tatsuya
T
Dept. of Thoracic and Cardiovascular Surgery, Wakayama Medical University.
Oura
Shoji
S
Hirai
Issei
I
Kokawa
Yozo
Y
Nishida
Munehiro
M
Sasaki
Rie
R
Kawago
Mitsumasa
M
Yuzaki
Mitsuru
M
Tanino
Hirokazu
H
Sakurai
Teruhisa
T
Okamura
Yoshitaka
Y
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003964:Diaphragm; D000077143:Docetaxel; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000494:pharmacology; D019042:Muscle Neoplasms / Q000473:pathology* / Q000601:surgery; D018218:Neoplasms, Fibrous Tissue / Q000473:pathology* / Q000601:surgery; D043823:Taxoids / Q000494:pharmacology; D000093542:Gemcitabine
D000970:Antineoplastic Agents; D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D016685:Mitomycin; D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil; D000093542:Gemcitabine