Supranigral injection of neuregulin1-beta induces striatal dopamine overflow.
Previous studies have provided anatomical evidence that the functional neuregulin receptor, ErbB4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. In this study, we provide evidence that neuregulin1-beta (a.k.a. heregulin1-beta), a neuregulin-1 gene isoform that preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. These data are indicative that neuregulins can modulate the activity of mesostriatal dopaminergic neurons.
Yurek
David M
DM
Department of Surgery/Neurosurgery, University of Kentucky College of Medicine, Health Sciences Research Building, Lexington, KY 40536-0305, USA. David.Yurek@uky.edu
Zhang
Lixin
L
Fletcher-Turner
Anita
A
Seroogy
Kim B
KB
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D066246:ErbB Receptors / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D008845:Microinjections; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D020890:Neuregulin-1 / Q000008:administration & dosage / Q000502:physiology*; D020033:Protein Isoforms; D051381:Rats; D017207:Rats, Sprague-Dawley; D066247:Receptor, ErbB-4; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*
D020890:Neuregulin-1; D020033:Protein Isoforms; C117467:neuregulin beta; C087230:heregulin beta1; D066246:ErbB Receptors; C587691:Erbb4 protein, rat; D066247:Receptor, ErbB-4; D004298:Dopamine