Understanding the roles of RecQ helicases in the maintenance of genome integrity and suppression of tumorigenesis.
RecQ helicases are evolutionarily conserved enzymes required for the maintenance of genome stability. Mutations in three of the five known human RecQ helicase genes cause distinct clinical disorders that are characterized by genome instability and cancer predisposition. Recent studies have begun to reveal the cellular roles of RecQ helicases and how these enzymes may prevent tumorigenesis at the molecular level.
Mankouri
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Cancer Research UK Genome Integrity Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX3 9DS, UK. h.mankouri@cancer.org.uk
Hickson
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ID
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D004265:DNA Helicases / Q000378:metabolism*; D016678:Genome; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000517:prevention & control*; D053484:RecQ Helicases; D012441:Saccharomyces cerevisiae / Q000201:enzymology
D000251:Adenosine Triphosphatases; C506725:RECQL protein, human; D004265:DNA Helicases; D053484:RecQ Helicases