title: Perinatal or early-postnatal cytomegalovirus infection in preterm infants under 34 weeks gestation born to CMV-seropositive mothers within a high-seroprevalence population.
abstract: In a prospective study, we evaluated the frequency, correlates, and clinical significance of perinatal or early-postnatal cytomegalovirus (CMV) infection in <34-week-gestation infants (n=95) born to CMV-seropositive mothers. None had congenital CMV infection. Overall, 21 (22.1%; 95% CI=14.2-31.8) infants were found to be infected; 10 excreted CMV at <60 days, and 11 had later excretion. Blood transfusion, birth weight, and vaginal delivery were not associated factors. Receiving natural breast milk within the first 30 days (OR=4.5, P=.02) or for >30 days (OR=7.9, P <.01) was associated with infection. Only one (4.8%) of the infected infants was symptomatic. For <34-week-gestation infants, frequency of perinatal and early-postnatal CMV infection is high. Early or prolonged exposure to breast milk is an associated factor. However, most infections are asymptomatic, indicating that CMV infection in preterm infants within such a population is a serious problem infrequently.
authors.affiliation: Department of Pediatrics, University of São Paulo School of Medicine, Brazil. mmmpinha@fmrp.usp.br
authors.forename: Marisa Márcia
authors.initials: MM
authors.lastname: Mussi-Pinhata
authors.forename: Aparecida Yulie
authors.initials: AY
authors.lastname: Yamamoto
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: do Carmo Rego
authors.forename: Patrícia Cristina Gomes
authors.initials: PC
authors.lastname: Pinto
authors.forename: Márcia Soares Freitas
authors.initials: MS
authors.lastname: da Motta
authors.forename: Cristina
authors.initials: C
authors.lastname: Calixto
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000175:diagnosis / Q000635:transmission*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000209:etiology*; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis; D011446:Prospective Studies
chemical_list: D000914:Antibodies, Viral