title: The influence of central corneal thickness and corneal curvature and axial length on the measurement of intraocular pressure.
abstract: OBJECTIVE
  To examine the influence of central corneal thickness (CCT), corneal curvature (CC), and axial length (AL) on intraocular pressure (IOP).
  
  
  METHODS
  Eighty-one clinically normal eyes were included in our study. The IOP, CCT, CC, AL were measured using a Goldmann applanation tonometer, optical pachymeter, keratometer and A-scan ultrasound biometer respectively in all subjects.
  
  
  RESULTS
  A highly significant positive correlation was identified between IOP and CCT. Linear regression analysis suggests that an increase in CCT of 0.010 mm is associated with a 4.946 mmHg increment in IOP. No significant positive correlation was identified between IOP and CC. P values are 0.724 and 0.414 respectively for vertical and horizontal readings. A paradoxically reversed correlation was present between IOP and axial length.
  
  
  CONCLUSIONS
  Corneal thickness is a very important confounding factor in the measurement of intraocular pressure, which warrants further attention in our clinical practice.
authors.affiliation: Medical College of Sun Yat-sen University, Guangzhou 510089, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Minru
authors.initials: M
authors.lastname: Li
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Fan
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D002648:Child; D003315:Cornea / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014065:Tonometry, Ocular / Q000295:instrumentation / Q000379:methods