title: [Intratympanic gentamicin in patients with Ménière's disease: analysis of our protocol].
abstract: OBJECTIVE
  The aim of this paper is to analyze the peculiarities of a protocol for treatment with intratympanic gentamicin in patients with Ménière's disease.
  
  
  METHODS
  71 patients with unilateral disabling Ménière's disease were followed for a period longer than two years after concluding the treatment. AAO-HNS criteria for reporting treatment results was followed. Gentamicin was applied weekly until of symptoms or signs of vestibular hypofunction were noticed.
  
  
  RESULTS
  Control of vertigo was obtained in 83% of the patients while in 24% a second course was needed beacuse of vertigo recurrence. 66% of the patients developed a typical syndrome of unilateral vestibular hypofunction in the ear treated.
  
  
  CONCLUSIONS
  Ending weekly injections of gentamicin for the treatment of patients with Ménière's disease when signs of vestibular hypofunction appear warrants a control of vertigo similar to that obtained in other series.
authors.affiliation: Servicio Otorrinolaringología, Hospital Casa de Salud, Valencia. emartin@clinicabarona.com
authors.forename: E
authors.initials: E
authors.lastname: Martín Sanz
authors.forename: N
authors.initials: N
authors.lastname: Pérez Fernández
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D014432:Tympanic Membrane / Q000187:drug effects*; D015837:Vestibular Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins