Synthesis of potential metabolites of (S)-(-)-bromofosfamide.
(S)-(-)-Bromofosfamide, a newly obtained anticancer agent, recently became a subject of phase I clinical trials in Poland. With the aim to study its metabolism in humans using phosphorus nuclear magnetic resonance a group of potential metabolites of this agent was synthesized.
Misiura
K
K
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Poland. kmisiura@bio.cbmm.lodz.pl
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D007069:Ifosfamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
D018906:Antineoplastic Agents, Alkylating; C073801:bromofosfamide; D007069:Ifosfamide