[Antiarrhythmic properties of 2-(2'-hydroxy-2')-substituted ethyl-1,2,3,4-octahydropyrrolo[1,2-a]pyrazines].
The antiarrhythmic activity and acute toxicity of a series of 2-(2'-hydroxy-2')-substituted ethyloctahydropyrrolo[1,2-a]pyrazines were studied. Two most promising compound (PV-238) is characterized by high antiarrhythmic activity, broad spectrum of action, and low toxicity.
Filippova
O V
OV
Kryzhanovskiĭ
S A
SA
Peresada
V P
VP
Likhosherstov
A M
AM
Revenko
S V
SV
Kaverina
N V
NV
Reznikov
K M
KM
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D011719:Pyrazines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats
D000889:Anti-Arrhythmia Agents; D011719:Pyrazines