[Effect of oral administration of guanxin II decoction on coronary blood flow and cardiac systolic/diastolic function in healthy males].
OBJECTIVE
To observe the effects of oral administration of guanxin II decoction (GX II) on cardiovascular function, especially on the dynamics of coronary blood flow in healthy males.


METHODS
Changes of heart rate, diastolic pressure, systolic pressure, left ventricular ejection fraction (LVEF), E peak, A peak, E/A value of mitral flow, diastolic peak velocity (Vmax) and diastolic flow velocity time integrals (VTI) of left anterior descending coronary artery (LAD) in 11 healthy male subjects were measured before and after oral administration of GX II, using non-invasive echocardiogram.


RESULTS
Compared with those before GX II administration, the changes after administration in heart rate, systolic pressure, diastolic pressure, LVEF, E peak, A peak and E/A value, were insignificantly different (P>0.05), but the Vmax and VTI significantly increased at 30 min, 60 min, 90 min and 120 min after GX II administration (P<0.05).


CONCLUSIONS
To increase the coronary blood flow is possibly one of the mechanisms of GX II in treating coronary heart disease and angina pectoris.
Gan
Hong-quan
HQ
Research Center of TCM, Xijing Hospital, Fourth Military Medical University, Xi'an (710033).
Huang
Xi
X
Tian
Xin-qiao
XQ
Zhu
Yongsheng
Y
Zhang
Shanhong
S
Li
Jun
J
Ren
Ping
P
Mei
Qibing
Q
D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy; D003331:Coronary Vessels / Q000187:drug effects / Q000648:ultrastructure; D003971:Diastole / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004452:Echocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D013599:Systole / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D014665:Vasodilator Agents