Influence of selected auxiliary substances on some physicochemical properties of solid dispersions containing magnesium salts.
In this survey magnesium sails in the form of solid dispersions were studied to examine the interaction of the drug and lecithin or Tego Betain L-7. The results of thermal analysis of solid dispersions containing magnesium adipate Mg[Adip] and compounds of this salt with glycine substituent, and the partition coefficient (logP) of this salts applied for solid dispersion, have been presented in this paper. Lecithin (45% phosphatidylcholine) or Tego Betain L-7 (30% solution of amide betaine) have been added to magnesium salts to obtain a solid dispersion. The influence of auxiliary substances: Tego Betain L-7 and lecithin on physicochemical properties of the examined preparations has been assessed. The results of thermal analysis (DTA, DSC, TG) of magnesium complexes indicated their good thermal resistance up to the temperature of 375 K.
Marcoin
Wacława
W
Chair and Department of Pharmaceutical Technology, Medical Academy of Silesia, 41-200 Sosnowiec, Poland.
Duda
Henryk
H
D000272:Adipates / Q000032:analysis / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D017616:Magnesium Compounds / Q000032:analysis* / Q000737:chemistry*
D000272:Adipates; D017616:Magnesium Compounds; C029900:adipic acid