title: A gene expression signature associated with metastatic outcome in human leiomyosarcomas.
abstract: Metastasis is a major factor associated with poor prognosis in cancer, but little is known of its molecular mechanisms. Although the clinical behavior of soft tissue sarcomas is highly variable, few reliable determinants of outcome have been identified. New markers that predict clinical outcome, in particular the ability of primary tumors to develop metastatic tumors, are urgently needed. Here, we have chosen leiomyosarcoma as a model for examining the relationship between gene expression profile and the development of metastasis in soft tissue sarcomas. Using cDNA microarray, we have identified a gene expression signature associated with metastasis in sarcoma that allowed prediction of the future development of metastases of primary tumors (Kaplan-Meier analysis P = 0.001). Our finding may aid the tailoring of therapy for individual sarcoma patients, where the aggressiveness of treatment is affected by the predicted outcome of disease.
authors.affiliation: The Male Urological Cancer Research Centre, Institute of Cancer Research, Surrey, United Kingdom. Yin-Fai-Lee@icr.ac.uk
authors.forename: Yin-Fai
authors.initials: YF
authors.lastname: Lee
authors.forename: Megan
authors.initials: M
authors.lastname: John
authors.forename: Alison
authors.initials: A
authors.lastname: Falconer
authors.forename: Sandra
authors.initials: S
authors.lastname: Edwards
authors.forename: Jeremy
authors.initials: J
authors.lastname: Clark
authors.forename: Penny
authors.initials: P
authors.lastname: Flohr
authors.forename: Toby
authors.initials: T
authors.lastname: Roe
authors.forename: Rubin
authors.initials: R
authors.lastname: Wang
authors.forename: Janet
authors.initials: J
authors.lastname: Shipley
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Grimer
authors.forename: D Chas
authors.initials: DC
authors.lastname: Mangham
authors.forename: J Meirion
authors.initials: JM
authors.lastname: Thomas
authors.forename: Cyril
authors.initials: C
authors.lastname: Fisher
authors.forename: Ian
authors.initials: I
authors.lastname: Judson
authors.forename: Colin S
authors.initials: CS
authors.lastname: Cooper
mesh_terms: D020869:Gene Expression Profiling; D006801:Humans; D007890:Leiomyosarcoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D012509:Sarcoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000556:secondary*