title: Assessment of diastolic function in patients with hypertrophic cardiomyopathy by Doppler tissue imaging.
abstract: OBJECTIVE
  To determine the clinical application of pulsed Doppler tissue imaging in assessing the left ventricular diastolic function and in discriminating between normal subjects and patients with hypertrophic cardiomyopathy with various stages of diastolic dysfunction.
  
  
  METHODS
  We measured the peak diastolic velocities of mitral annulus in 81 patients with hypertrophic cardiomyopathy with various stages of diastolic dysfunction and 50 normal volunteers by Doppler tissue imaging using the apical window at 2-chamber and long apical views, respectively. The myocardial velocities were determined with use of variance F statistical analysis.
  
  
  RESULTS
  Early diastolic myocardial velocities of mitral annulus were higher in normal subjects than in patients with hypertrophic cardiomyopathy with either delayed relaxation, pseudonormal filling, or restrictive filling. However, peak myocardial velocities of mitral annulus during atrial contraction were similar in normal subjects and patients with hypertrophic cardiomyopathy.
  
  
  CONCLUSIONS
  Doppler tissue imaging can directly reflect upon left diastolic ventricular function. Early phase of diastole was the best discriminator between control subjects and patients with hypertrophic cardiomyopathy.
authors.affiliation: Department of Ultrasound, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Xiu-zhang
authors.initials: XZ
authors.lastname: Lü
authors.forename: Hong-chang
authors.initials: HC
authors.lastname: Yang
authors.forename: Fu-jian
authors.initials: FJ
authors.lastname: Duan
authors.forename: Zhen-hui
authors.initials: ZH
authors.lastname: Zhu
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D016277:Ventricular Function, Left