title: Suspected central anticholinergic syndrome in a 6-week-old infant.
abstract: A 6-wk-old male infant became unresponsive after an uneventful general anesthetic for hernia repair. His symptoms were consistent with central anticholinergic syndrome. He appeared to awaken after treatment with IV physostigmine in a dose of 0.04 mg/kg. Because of the recurrence of sedation, a second physostigmine infusion was administered, which again led to transient arousal. Finally, the patient awoke spontaneously after 24 h and recovered uneventfully.
authors.affiliation: *Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, and †Department of Surgery, Prosper-Hospital, Recklinghausen, Germany; and ‡Department of Anesthesiology and Intensive Care Medicine, Evangelisches Krankenhaus Oberhausen, Oberhausen, Germany.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Kulka
authors.forename: Hakki
authors.initials: H
authors.lastname: Toker
authors.forename: Jörg
authors.initials: J
authors.lastname: Heim
authors.forename: Alexander
authors.initials: A
authors.lastname: Joist
authors.forename: Jens
authors.initials: J
authors.lastname: Jakschik
mesh_terms: D000768:Anesthesia, General; D001143:Arousal / Q000187:drug effects; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D059685:Herniorrhaphy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007431:Intraoperative Complications / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D010830:Physostigmine / Q000009:adverse effects; D013577:Syndrome
chemical_list: D018680:Cholinergic Antagonists; D010830:Physostigmine