Hypoxic-ischemic brain injury in the term infant-current concepts.
An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.
Shalak
Lina
L
Department of Pediatrics, Southwestern Medical Center, University of Texas, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Perlman
Jeffrey M
JM
D001921:Brain / Q000473:pathology; D002547:Cerebral Palsy / Q000209:etiology; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D018696:Neuroprotective Agents / Q000627:therapeutic use; D015427:Reperfusion Injury / Q000209:etiology* / Q000473:pathology / Q000628:therapy*
D018696:Neuroprotective Agents