title: In vitro antiviral diterpenes from the Brazilian brown alga Dictyota pfaffii.
abstract: Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-di-hydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude ex-tract of D. pfaffii. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.
authors.affiliation: Post-Graduate Program in Organic Chemistry, Institute of Chemistry, Universidade Federal Fluminense, Niterói, 24001-970 Rio de Janeiro, Brazil.
authors.forename: Jussara Pinheiro
authors.initials: JP
authors.lastname: Barbosa
authors.forename: Renato Crespo
authors.initials: RC
authors.lastname: Pereira
authors.forename: Juliana Lourenço
authors.initials: JL
authors.lastname: Abrantes
authors.forename: Cláudio César
authors.initials: CC
authors.lastname: Cirne dos Santos
authors.forename: Moacyr Alcoforado
authors.initials: MA
authors.lastname: Rebello
authors.forename: Izabel Christina de Palmer Paixão
authors.initials: IC
authors.lastname: Frugulhetti
authors.forename: Valéria Laneuville
authors.initials: VL
authors.lastname: Texeira
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects*; D008519:Medicine, Traditional; D000459:Phaeophyceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014709:Vero Cells / Q000821:virology
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; D010936:Plant Extracts