Synthesis of new N-(2-(trifluoromethyl)pyridin-4-yl)anthranilic acid derivatives and their evaluation as anticancer agents.
The N-(2-(trifluoromethyl)pyridin-4-yl)anthranilic acid 6 and a series of its ester and amide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against human cancer cells. Ester derivatives 13 and 18 exhibited potent growth inhibitory activity with GI(50) values at nanomolar concentrations. Among amide derivatives, N-anthraniloylglycinate 19 shown moderate inhibitory activity in the full panel cancer cell line screening.
Cocco
Maria T
MT
Dipartimento di Tossicologia, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy.
Congiu
Cenzo
C
Lilliu
Valentina
V
Onnis
Valentina
V
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D062367:ortho-Aminobenzoates