Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae.
Prevention of nasopharyngeal colonization may reduce the burden of pneumococcal infection during infancy. Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n=8 per group) during pregnancy was examined for inhibition of adherence of Streptococcus pneumoniae serotypes 6B and 14 to pharyngeal epithelial cells in vitro. Pneumococcal adherence was significantly reduced in the presence of breast milk (P< or =.0001 for S. pneumoniae serotype 14; P=.036 for serotype 6B), independent of the concentration of secretory IgA antibodies. Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells. In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants.
Deubzer
Hedwig E
HE
Imperial College, Faculty of Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, United Kingdom.
Obaro
Stephen K
SK
Newman
Vanessa O
VO
Adegbola
Richard A
RA
Greenwood
Brian M
BM
Henderson
Don C
DC
D000907:Antibodies, Bacterial / Q000276:immunology; D000915:Antibody Affinity; D001422:Bacterial Adhesion; D002478:Cells, Cultured; D003126:Colostrum / Q000276:immunology*; D004311:Double-Blind Method; D004847:Epithelial Cells / Q000382:microbiology*; D005260:Female; D005714:Gambia; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology; D010614:Pharynx / Q000166:cytology / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011247:Pregnancy; D013296:Streptococcus pneumoniae / Q000502:physiology*
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D022242:Pneumococcal Vaccines