The ketogenic diet does not alter brain expression of orexigenic neuropeptides.
Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ hybridization revealed no effect of the KD on NPY or galanin mRNA expression, suggesting that increased expression of NPY and galanin do not contribute to the anticonvulsant effect of the KD.
Tabb
Kroshona
K
Department of Human Genetics, Emory University School of Medicine, Whitehead Building, Suite 301, 615 Michael Street, Atlanta, GA 30322, USA.
Szot
Patricia
P
White
Sylvia S
SS
Liles
L Cameron
LC
Weinshenker
David
D
D020155:3-Hydroxybutyric Acid / Q000097:blood; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D004827:Epilepsy / Q000178:diet therapy*; D019004:Galanin / Q000096:biosynthesis*; D017403:In Situ Hybridization; D007659:Ketones / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009478:Neuropeptide Y / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012640:Seizures / Q000139:chemically induced / Q000178:diet therapy
D007659:Ketones; D009478:Neuropeptide Y; D012333:RNA, Messenger; D019004:Galanin; D020155:3-Hydroxybutyric Acid