title: Catalytic transformations with copper-metalated diglycine conjugates.
abstract: A series of copper-metalated, water-soluble bis-diglycine conjugates were synthesized and characterized through spectroscopic methods. These conjugates were evaluated for the cleavage of phosphodiester substrates, supercoiled plasmid relaxation in the presence of co-oxidants, and for the oxidation of a diphenolic substrate, 2,6-dimethoxyphenol. Appreciable rate enhancements were observed for these reactions and the oxidative nucleolytic cleavage activity and phenol oxidative coupling was presumably manifested via formation of reactive oxygen species.
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur 208016, India.
authors.forename: C
authors.initials: C
authors.lastname: Madhavaiah
authors.forename: Masood
authors.initials: M
authors.lastname: Parvez
authors.forename: Sandeep
authors.initials: S
authors.lastname: Verma
mesh_terms: D020134:Catalytic Domain / Q000187:drug effects / Q000502:physiology; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D006033:Glycylglycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D006033:Glycylglycine; D003300:Copper