[Implication of non-perforating deep sclerectomy with amniotic membrane implantation for primary open-angle glaucoma].
OBJECTIVE
To evaluate the efficacy of non-perforating deep sclerectomy (NPDS) with amniotic membrane implantation for primary open-angle glaucoma (POAG).


METHODS
Fourteen cases (23 eyes) of POAG underwent NPDS with amniotic membrane implantation. NPDS was performed with a fornix-based conjunctival flap using 0. 04% mitomycin C(MMC) under the scleral flap for 4 minutes. A 6 mm x 9 mm amniotic membrane was then placed under the scleral flap and sutured using 10-0 nylon.


RESULTS
One month postoperatively, the intraocular pressure (IOP) was less or equal to 21 mmHg in 23 eyes, with a total success rate of 100%. After 3 months of follow-up for 20 eyes, the completely success rate was 90%, and the partly success rate was 100%. After 6 months of follow-up for 11 eyes, the completely success rate was 72.7%, the partly success rate was 100%, and the visual acuity had no significance between the pre-operation and post-operation. After 12 months of follow-up for 6 eyes, the success rate was 66. 7%. A good bleb formation was seen in the eyes and the IOP was controlled successfully. No serious complication was found in all eyes.


CONCLUSIONS
Amniotic membrane is an effective and safe implantation material for NPDS.
Ye
Wen
W
The Department of Ophthalmology, Ruijin Hospital affiliated Shanghai Second Medical University, Shanghai 200025, China.
Sun
Jingfeng
J
Zhong
Yisheng
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000650:Amnion / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D012599:Sclerostomy / Q000379:methods*; D014130:Trabeculectomy / Q000379:methods; D016896:Treatment Outcome
D016685:Mitomycin