Antenatal risk factors associated with the development of lenticulostriate vasculopathy (LSV) in neonates.
OBJECTIVE
To determine the antenatal risk factors associated with neonatal lenticulostriate vasculopathy (LSV).


METHODS
Women in preterm labor were randomized to magnesium sulfate (MgSO4), other tocolytic, or saline control. The surviving babies underwent head ultrasounds (HUS) (weeks of life 1, 2, and 4) and periodic developmental examinations (months 4, 8, 12, and 18).


RESULTS
Of 140 infants, 17.1% (24) had neonatal intraventricular hemorrhage (IVH), and 10.0% (14) had LSV (half of the latter (7 of 14) had both IVH and LSV). In a regression model in which other risk factors were controlled for, the association between antenatal exposures to tocolytic MgSO4 >or=50 g and LSV were significant (adjusted odds ratio (OR), 8.3; 95% confidence interval (CI), 1.5 to 45.0; p=0.01).


CONCLUSIONS
Based on our data and their analyses, we infer that antenatal exposure to high-dosage, tocolytic MgSO4 may be associated with LSV.
Mittendorf
Robert
R
Department of Obstetrics and Gynecology (R.M., J.G.G.), Loyola University Medical Center, Maywood, IL 60153, USA.
Kuban
Karl
K
Pryde
Peter G
PG
Gianopoulos
John G
JG
Yousefzadeh
David
D
D000328:Adult; D020144:Basal Ganglia Cerebrovascular Disease / Q000139:chemically induced*; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D015149:Tocolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*
D015149:Tocolytic Agents; D008278:Magnesium Sulfate