[Effect of smoking on the effectiveness of antimalarial drugs for cutaneous lesions of patients with lupus: assessment in a prospective study].
OBJECTIVE
Smoking has been involved in the failure of antimalarial therapy in patient with chronic or subacute erythematosus lupus.


METHODS
We report a prospective study of 26 patients with chronic, subacute or systemic erythematosus lupus who were treated with antimalarials. Several variables including smoking are compared in responders and non-responders.


RESULTS
Despite the reduced number of patients study that does not permit to allow significative results, it seems that among responders and non-responders, in other respects comparables, there is no difference in the presence of smoking, its quantity or its duration.


CONCLUSIONS
The significance of molecular interactions between some components of tobacco and antimalarials have still to be established.
Lardet
D
D
Service de dermatologie, hôpital Fournier, CHU de Nancy, 36, quai de la bataille, 54000 Nancy, France.
Martin
S
S
Truchetet
F
F
Cuny
J F
JF
Virion
J M
JM
Schmutz
J L
JL
D000328:Adult; D000368:Aged; D000465:Algorithms; D000962:Antimalarials / Q000627:therapeutic use*; D016022:Case-Control Studies; D002738:Chloroquine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use*; D008178:Lupus Erythematosus, Cutaneous / Q000188:drug therapy*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D000962:Antimalarials; D006886:Hydroxychloroquine; D002738:Chloroquine