title: Compatibility of sennoside A and B with pharmaceutical excipients.
abstract: This study reports the incompatibility of sennoside A and B with the following commonly used pharmaceutical excipients: stearic acid, sodium carbonate, glucose, lactose, propyl paraben, sodium carbonate, stearic acid, citric acid, PEG, and sorbitol. Drug-excipient compatibility was tested using thermal (DSC) and analytical (HPLC) methods of analysis. Compatibility evaluation showed that dry powder mixtures could be used to formulate sennoside A and B products. However, when mixed with water--propyl paraben, sodium carbonate, stearic acid, citric acid, PEG, and sugar derivatives such as lactose, glucose and sorbitol--should not be used in sennoside containing products.
authors.affiliation: Research Institute for Industrial Pharmacy, North-West University, Potchefstroom Campus, Potchefstroom, South Africa.
authors.forename: Q
authors.initials: Q
authors.lastname: Verloop
authors.forename: A F
authors.initials: AF
authors.lastname: Marais
authors.forename: M M
authors.initials: MM
authors.lastname: de Villiers
authors.forename: W
authors.initials: W
authors.lastname: Liebenberg
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004344:Drug Incompatibility; D005079:Excipients; D011208:Powders; D012676:Senna Extract; D000081226:Sennosides
chemical_list: D000880:Anthraquinones; D005079:Excipients; D011208:Powders; D000081226:Sennosides; D012676:Senna Extract