Effect of Boo Yong-Tang on mast cell-mediated allergic reaction.
Boo Yong-Tang (BYT) is an Oriental herbal prescription, which has been clinically applied for treatment of allergic disorders. Here, we report inhibitory effects of BYT on experimental allergic reactions. BYT increased interferon-gamma secretion from MOLT-4 T cells. When BYT (0.01, 0.1, or 1 g/kg) was orally administered for 1 h in mice, compound 48/80-induced ear swelling was significantly reduced. BYT also inhibited the histamine release from the mast cells activated by compound 48/80. In addition, BYT showed an inhibitory effect of anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction. These findings provide evidence that BYT is a potential prescription for the treatment of allergic reaction through down-modulating of mast cell activation.
Na
Ho-Jeong
HJ
College of Oriental Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul, Republic of Korea.
Jeong
Hyun-Ja
HJ
Hong
Seung-Heon
SH
Hwang
Chung-Yeon
CY
Cha
Wung-Suk
WS
Kim
Hyung-Min
HM
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D004427:Ear Diseases / Q000188:drug therapy / Q000209:etiology; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000209:etiology; D007271:Injections, Intradermal; D007371:Interferon-gamma / Q000096:biosynthesis; D007723:Korea; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D003189:p-Methoxy-N-methylphenethylamine
D018926:Anti-Allergic Agents; D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine; D007371:Interferon-gamma