A modular approach to DNA-programmed self-assembly of macromolecular nanostructures.
DNA-programmed organic reactions are new and powerful tools for assembling chemical compounds into predetermined complex structures and a brief review of their use is given. This approach is particular efficient for the selection and covalent coupling of multiple components. DNA-templated synthesis is used for polymerization of PNA tetramers and for copying of the connectivity information in DNA. Direct DNA-programmed multicomponent coupling of custom designed organic modules is described. The macromolecular structures obtained are highly conjugated potentially conducting nanoscaffolds. Some future developments in this area are discussed.
Gothelf
Kurt V
KV
Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark. kvg@chem.au.dk
Brown
Raymond S
RS
D004247:DNA / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods
D046911:Macromolecular Substances; D004247:DNA