title: New variant of the human metapneumovirus (HMPV) associated with an acute and severe exacerbation of asthma bronchiale.
abstract: Recently, an increasing number of studies demonstrated that the human metapneumovirus (HMPV) causes mild to severe respiratory infections in children and immunosuppressed adults, and may be a frequent but somewhat undervalued pathogen. Here, we report the detection of a new variant of HMPV that is not closely related to the HMPV strains described until now. The strain was detected in a 6.5-year-old girl with an acute and severe exacerbation of asthma bronchiale triggered by an infection with a newly detected HMPV variant. The presented data provide new information on genetic heterogeneity of HMPV and necessitate an optimization of diagnostic procedures for the detection of HMPV infection.
authors.affiliation: Institute for Medical Microbiology and Immunology, University Hospital Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. schildgen@mibi03.meb.uni-bonn.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Schildgen
authors.forename: Tilman
authors.initials: T
authors.lastname: Geikowski
authors.forename: Thomas
authors.initials: T
authors.lastname: Glatzel
authors.forename: Arne
authors.initials: A
authors.lastname: Simon
authors.forename: Anja
authors.initials: A
authors.lastname: Wilkesmann
authors.forename: Michael
authors.initials: M
authors.lastname: Roggendorf
authors.forename: Sergei
authors.initials: S
authors.lastname: Viazov
authors.forename: Bertfried
authors.initials: B
authors.lastname: Matz
mesh_terms: D000208:Acute Disease; D001249:Asthma / Q000150:complications / Q000821:virology*; D002648:Child; D005260:Female; D006801:Humans; D029121:Metapneumovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D018184:Paramyxoviridae Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics
chemical_list: D012367:RNA, Viral