title: MPC1001 and its analogues: new antitumor agents from the fungus Cladorrhinum species.
abstract: [structure: see text] Eight new compounds, MPC1001 and MPC1001B-H, were isolated from the fungus Cladorrhinum sp. KY4922. Multiple NMR experiments and CD data revealed MPC1001 to be an O-methyl derivative of emestrin, a 15-membered antifungal antibiotic containing a unique epidithiodioxopiperazine skeleton. Other compounds were elucidated to be structurally related novel analogues. MPC1001 and the analogues exerted potent antiproliferative activities against a human tumor cell line.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahimachi, Machida, Tokyo 194-8533, Japan. hideyuki.onodera@kyowa.co.jp
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Onodera
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Noriko
authors.initials: N
authors.lastname: Tsumagari
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Nakai
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Ogawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kanda
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry; D020037:Sordariales / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C493112:MPC1001; D010879:Piperazines