title: Plant serine/arginine-rich proteins and their role in pre-mRNA splicing.
abstract: Pre-messenger RNA (pre-mRNA) splicing, a process by which mature mRNAs are generated by excision of introns and ligation of exons, is an important step in the regulation of gene expression in all eukaryotes. Selection of alternative splice sites in a pre-mRNA generates multiple mRNAs from a single gene that encode structurally and functionally distinct proteins. Alternative splicing of pre-mRNAs contributes greatly to the proteomic complexity of plants and animals and increases the coding potential of a genome. However, the mechanisms that regulate constitutive and alternative splicing of pre-mRNA are not understood in plants. A serine/arginine-rich (SR) family of proteins is implicated in constitutive and alternative splicing of pre-mRNAs. Here I review recent progress in elucidating the roles of serine/arginine-rich proteins in pre-mRNA splicing.
authors.affiliation: Department of Biology and Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA. reddy@lamar.colostate.edu
authors.forename: Anireddy S N
authors.initials: AS
authors.lastname: Reddy
mesh_terms: D017398:Alternative Splicing / Q000502:physiology; D001120:Arginine / Q000737:chemistry; D018506:Gene Expression Regulation, Plant; D010940:Plant Proteins / Q000737:chemistry / Q000378:metabolism*; D012326:RNA Splicing / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D018749:RNA, Plant / Q000378:metabolism; D012694:Serine / Q000737:chemistry
chemical_list: D010940:Plant Proteins; D012333:RNA, Messenger; D018749:RNA, Plant; D012694:Serine; D001120:Arginine