title: CREB binding protein functions during successive stages of eye development in Drosophila.
abstract: During the development of the compound eye of Drosophila several signaling pathways exert both positive and inhibitory influences upon an array of nuclear transcription factors to produce a near-perfect lattice of unit eyes or ommatidia. Individual cells within the eye are exposed to many extracellular signals, express multiple surface receptors, and make use of a large complement of cell-subtype-specific DNA-binding transcription factors. Despite this enormous complexity, each cell will make the correct developmental choice and adopt the appropriate cell fate. How this process is managed remains a poorly understood paradigm. Members of the CREB binding protein (CBP)/p300 family have been shown to influence development by (1) acting as bridging molecules between the basal transcriptional machinery and specific DNA-binding transcription factors, (2) physically interacting with terminal members of signaling cascades, (3) acting as transcriptional coactivators of downstream target genes, and (4) playing a key role in chromatin remodeling. In a screen for new genes involved in eye development we have identified the Drosophila homolog of CBP as a key player in both eye specification and cell fate determination. We have used a variety of approaches to define the role of CBP in eye development on a cell-by-cell basis.
authors.affiliation: Department of Biology, Indiana University, Bloomington, Indiana 47401, USA. jkumar@bio.indiana.edu
authors.forename: Justin P
authors.initials: JP
authors.lastname: Kumar
authors.forename: Tazeen
authors.initials: T
authors.lastname: Jamal
authors.forename: Alex
authors.initials: A
authors.lastname: Doetsch
authors.forename: F Rudolf
authors.initials: FR
authors.lastname: Turner
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Duffy
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics / Q000378:metabolism; D050882:CREB-Binding Protein; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000378:metabolism; D047108:Embryonic Development; D005123:Eye / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*
chemical_list: D002843:Chromatin; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D015534:Trans-Activators; D050882:CREB-Binding Protein