title: Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons.
abstract: Using whole-cell patch clamp technique on the membrane of freshly isolated dorsal root ganglion (DRG) neurons, the effects of dragon's blood resin and its important component loureirin B on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium currents were observed. The results show that both blood resin and loureirin B could suppress TTX-S voltage-gated sodium currents in a dose-dependent way. The peak current amplitudes and the steady-state activation and inactivation curves are also made to shift by 0.05% blood resin and 0.2 mmol/L loureirin B. These results demonstrate that the effects of blood resin on TTX-S sodium current may contribute to loureirin B in blood resin. Perhaps the analgesic effect of blood resin is caused partly by loureirin B directly interfering with the nociceptive transmission of primary sensory neurons.
authors.affiliation: Department of Biological & Medical Engineering, South-Central University for Nationalities, Wuhan 430074, China. liu.xiangming@263.net
authors.forename: Liu
authors.initials: L
authors.lastname: Xiangming
authors.forename: Chen
authors.initials: C
authors.lastname: Su
authors.forename: Yin
authors.initials: Y
authors.lastname: Shijin
authors.forename: Mei
authors.initials: M
authors.lastname: Zhinan
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D004594:Electrophysiology; D005727:Ganglia, Spinal / Q000166:cytology*; D008516:Medicine, Chinese Traditional; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D012116:Resins, Plant / Q000494:pharmacology*; D015222:Sodium Channels / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology*
chemical_list: D012116:Resins, Plant; D015222:Sodium Channels; D013779:Tetrodotoxin; C505764:loureirin B