Positionally cloned susceptibility genes in allergy and asthma.
After several years of research to find asthma-susceptibility genes using genome-wide linkage scans and refined genetic mapping methods, four highly interesting candidate genes have recently been reported. Each of these genes represents a different functional class, and might point to a new pathway in the pathogenesis of asthma. Current research is focusing on confirming the genetic associations in diverse populations and understanding the biochemical functions of the proteins. These second-generation candidate genes for asthma susceptibility will stimulate much research, and might also enable the testing of multigenic models with sufficiently large sample sets.
Kere
Juha
J
Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland. juha.kere@biosci.ki.se
Laitinen
Tarja
T
D051722:ADAM Proteins; D001249:Asthma / Q000235:genetics*; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D004268:DNA-Binding Proteins / Q000235:genetics; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D008666:Metalloendopeptidases / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; C484532:NPSR1 protein, human; C493258:PHF11 protein, human; D043562:Receptors, G-Protein-Coupled; D014157:Transcription Factors; C476879:DPP10 protein, human; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D051722:ADAM Proteins; C450441:ADAM33 protein, human; D008666:Metalloendopeptidases