Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancer.
Tankyrase promotes telomere elongation by interaction with the telomeric protein binding factor TRF1, a negative regulator of telomere extension. We measured tankyrase mRNA by real-time RT-PCR in 66 breast cancers and in paired normal tissues. Results were compared with hTERT mRNA expression. The levels of tankyrase in breast cancers were significantly higher in comparison to normal tissues (P<0.0001) and significantly related to the status of progesterone receptors. No relationship was found between tankyrase and hTERT mRNA expression in breast cancers. According to our results, tankyrase expression appeared up regulated in breast cancers.
Gelmini
Stefania
S
Clinical Biochemistry Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.
Poggesi
Melissa
M
Distante
Vito
V
Bianchi
Simonetta
S
Simi
Lisa
L
Luconi
Michaela
M
Raggi
Claudia Casini
CC
Cataliotti
Luigi
L
Pazzagli
Mario
M
Orlando
Claudio
C
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins; D011980:Receptors, Progesterone; D020133:Reverse Transcriptase Polymerase Chain Reaction; D038501:Tankyrases / Q000096:biosynthesis*; D019098:Telomerase / Q000096:biosynthesis; D014407:Tumor Cells, Cultured
D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D011980:Receptors, Progesterone; D038501:Tankyrases; D019098:Telomerase; C418109:TNKS protein, human