[Analysis of p53 gene mutation in salivary adenoid cystic carcinoma.].
OBJECTIVE
The purpose of this study was to investigate the occurrence of p53 gene mutation in salivary adenoid cystic carcinoma, the correlation between the gene and prognostic significance.


METHODS
A series of salivary adenoid cystic carcinoma were studied by polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) analysis to detect p53 mutation, respectively.


RESULTS
The result showed that p53 gene mutations in exon 5-8 were detected in 65.8% (25/38) of the salivary adenoid cystic carcinoma. The p53 gene mutation was related to tumor distant metastasis and tumor recurrence (P<0.05) but not related to pathological types, clinical stages (P>0.05).There was a significant correlation between p53 gene mutation and postoperative survival .


CONCLUSIONS
It is suggested that p53 gene mutations were very common in salivary adenoid cystic carcinoma, and might be useful in screening progress and evaluating prognosis of patients.
Zhang
Dong-sheng
DS
Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong Province, China. ds63zhang@hotmail.com.
Bian
Cui-rong
CR
Wang
Pei-yu
PY
Yuan
Xi-lan
XL
Wang
Jia-yao
JY
D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis