High-mobility group protein 1(Y): metastasis-associated or metastasis-inducing?
Metastasis is the major cause of mortality and morbidity for patients with cancer. The high-mobility group protein 1(Y) [HMG-1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG-1(Y) in metastasis.
Evans
Alice
A
School of Surgical and Reproductive Sciences and Northern Institute for Cancer Research, Faculty of Medical Sciences, University of Newcastle-upon-Tyne, United Kingdom.
Lennard
Thomas W J
TW
Davies
Barry R
BR
D000818:Animals; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology; D002450:Cell Communication; D002453:Cell Cycle; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000473:pathology; D005260:Female; D016147:Genes, Tumor Suppressor; D025741:HMGA1a Protein / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008223:Lymphoma / Q000737:chemistry / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000473:pathology*; D009369:Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology*; D009447:Neuroblastoma / Q000737:chemistry / Q000473:pathology; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology; D012333:RNA, Messenger / Q000032:analysis
D012333:RNA, Messenger; D025741:HMGA1a Protein