[Electrospun poly-l-lactide nanofibres as scaffolds for tissue engineering].
Tissue engineering is a promising tool for treating structural and functional defects in bone and cartilage. To provide optimal conditions for three-dimensional cell growth the use of a scaffold is necessary. The aim of the study was to test the potential application of an electrospun poly (l-lactide)-nanostructured scaffold as a matrix for tissue engineering. Matrices were seeded with human osteosarcoma MG-63 cells and cultivated for 14 days. Cells showed a clear preference for growth along the nanofibres, and demonstrated no signs of degeneration or apoptosis. The fine structure of electrospun nanofibres makes them an ideal scaffold for tissue engineering, in particular for cartilage repair. They can be "doped" with growth factors, medications, etc., and are both biocompatible and biodegradable.
Boudriot
U
U
Klinik für Orthopädie und Rheumatologie, Philipps-Universität Marburg, Baldinger Strasse, 35033 Marburg.
Dersch
R
R
Goetz
B
B
Griss
P
P
Greiner
A
A
Wendorff
J H
JH
D017209:Apoptosis / Q000502:physiology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000502:physiology*; D003470:Culture Media; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000295:instrumentation*; D011091:Polyesters; D046509:Tissue Culture Techniques / Q000295:instrumentation*; D023822:Tissue Engineering / Q000295:instrumentation*; D014407:Tumor Cells, Cultured / Q000166:cytology
D003470:Culture Media; D011091:Polyesters; C033616:poly(lactide)