title: Tritium labelling of dopaminergic ligands domperidone and (+/-)-7-hydroxy DPAT.
abstract: Methods are presented for tritiating the D2 specific dopaminergic antagonist domperidone and D3 specific dopaminergic agonist (+/-)-7-hydroxy DPAT. Techniques to characterize the products of the tritiation are also given.
authors.affiliation: Custom Synthesis, PerkinElmer Life and Analytical Sciences, Inc., 549 Albany St., Boston, MA 02118, USA.
authors.forename: Scot
authors.initials: S
authors.lastname: Pounds
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Seguin
authors.forename: Crist N
authors.initials: CN
authors.lastname: Filer
mesh_terms: D004294:Domperidone / Q000737:chemistry*; D065127:Dopamine D2 Receptor Antagonists; D007553:Isotope Labeling / Q000379:methods*; D008024:Ligands; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013764:Tetrahydronaphthalenes / Q000737:chemistry*; D014316:Tritium / Q000737:chemistry*
chemical_list: D065127:Dopamine D2 Receptor Antagonists; D008024:Ligands; D019275:Radiopharmaceuticals; D013764:Tetrahydronaphthalenes; D014316:Tritium; D004294:Domperidone; C031349:7-hydroxy-2-N,N-dipropylaminotetralin