[Structural modification and bioactivity of cyclovirobuxine D].
OBJECTIVE
To search for new compounds for the treatment of cardiovascular diseases by structural modification of cyclovirobuxine D.


METHODS
According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.


RESULTS
Ten new compounds were syntheized and confirmed by spectra.


CONCLUSIONS
Endurance lacking oxygen activity and antiarrhythmia effects of some analogues of cyclovirobuxine D were tested. Some compounds showed better activity than cyclovirobuxine D.
Deng
Lan
L
West China School of Pharmacy, Sichuan University, China. denglan234@sina.com
Huang
Heng
H
Xu
Ming-xia
MX
Zhou
Shi-qing
SQ
Wang
Xing-wen
XW
Lu
Miao
M
Ren
Fang
F
Li
Dai-qing
DQ
D015308:Anaerobic Threshold / Q000187:drug effects*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D031235:Buxus / Q000737:chemistry; D002725:Chloroform; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal; C032939:cyclovirobuxine D; D002725:Chloroform