title: Variation of toxigenic Vibrio cholerae O1 in the aquatic environment of Bangladesh and its correlation with the clinical strains.
abstract: The diversity of toxigenic V. cholerae O1 in the aquatic environment of Bangladesh is not known. A total of 18 environmental and 18 clinical strains of toxigenic V. cholerae O1 were isolated simultaneously from four different geographical areas and tested for variation by the pulsed-field gel electrophoresis method. Environmental strains showed diversified profiles and one of the profiles was common to some environmental strains and most clinical strains. It appears that one clone has an advantage over others to cause disease. These findings suggest that the study of the molecular ecology of V. cholerae O1 in relation to its environmental reservoir is important in identifying virulent strains that cause disease.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. sislam@icddrb.org
authors.forename: Mohammad Sirajul
authors.initials: MS
authors.lastname: Islam
authors.forename: Kaisar Ali
authors.initials: KA
authors.lastname: Talukder
authors.forename: Nurul Huda
authors.initials: NH
authors.lastname: Khan
authors.forename: Zahid Hayat
authors.initials: ZH
authors.lastname: Mahmud
authors.forename: Mohammed Ziaur
authors.initials: MZ
authors.lastname: Rahman
authors.forename: Gopinath Balakrish
authors.initials: GB
authors.lastname: Nair
authors.forename: Abul K M
authors.initials: AK
authors.lastname: Siddique
authors.forename: Mohammad
authors.initials: M
authors.lastname: Yunus
authors.forename: David Allen
authors.initials: DA
authors.lastname: Sack
authors.forename: Richard Bradley
authors.initials: RB
authors.lastname: Sack
authors.forename: Anwar
authors.initials: A
authors.lastname: Huq
authors.forename: Rita R
authors.initials: RR
authors.lastname: Colwell
mesh_terms: D000818:Animals; D001459:Bangladesh / Q000453:epidemiology; D002771:Cholera / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology; D002772:Cholera Toxin / Q000096:biosynthesis* / Q000378:metabolism / Q000633:toxicity; D016521:Electrophoresis, Gel, Pulsed-Field / Q000379:methods; D014644:Genetic Variation; D014734:Vibrio cholerae / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D014871:Water Microbiology
chemical_list: D002772:Cholera Toxin