title: [Resistance to antibiotics used in Helicobacter pylori infection in children].
abstract: In literature and clinical findings, the attention has been turned to the resistance to the antibiotics used in Helicobacter pylori eradication, especially metronidazole and clarithromycin. Drug-resistance was evaluated in 50 children. Primary drug-resistance to the antibiotics used in eradications was determined in this group, and additionally, in 18 children who were subjected twice to unsuccessful eradicative therapy. The highest secondary resistance to metronidazole up to 72.0% was found among conventionally used antibiotics. Primary resistance of H. pylori rods to clarithromycin was also high and equaled 25.0%. However, in our study secondary resistance to macrolides was about 66.0%. In our study combined primary resistance to clarithromycin and metronidazole was about 7.2%. There was not H. pylori rods resistance to amoxicillin and tetracyclines.
authors.affiliation: III Klinika Chorób Dzieci AM w Białymstoku. emaciorkowska@o2.pl
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Maciorkowska
authors.forename: Maciej
authors.initials: M
authors.lastname: Kaczmarski
authors.forename: Jarosław
authors.initials: J
authors.lastname: Kowalczuk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kondej-Muszyńska
authors.forename: Izabela
authors.initials: I
authors.lastname: Roszko
authors.forename: Justyna
authors.initials: J
authors.lastname: Cieśla
authors.forename: Agata
authors.initials: A
authors.lastname: Zielińska
authors.forename: Sami
authors.initials: S
authors.lastname: Musaibili
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D017291:Clarithromycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013754:Tetracyclines / Q000494:pharmacology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D008795:Metronidazole; D000658:Amoxicillin; D017291:Clarithromycin