title: [A case of transitional cell carcinoma of the renal pelvis with adenocarcinoma producing CEA and CA19-9].
abstract: We report a case of invasive renal pelvic tumor with high serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9). An 86-year-old man presented with macrohematuria. Retrograde pyelography demonstrated a filling defect in right upper calyx, suspected of renal pelvic tumor. The levels of serum CEA and CA 19-9 were elevated to 28.0 ng/ml and 122 U/ml, respectively. No abnormalities were found in the gastrointestinal tract. Right nephroureterectomy was performed, and histopathological diagnosis was transitional cell carcinoma, grade 2>grade 3, accompanied with adenocarcinoma immuno-stained for CEA and CA19-9. A part of the tumor showed a tubular growth pattern. Both serum levels of CEA and CA 19-9 immediately decreased to the normal range after the operation, but increased again with lung and hepatic metastases.
authors.affiliation: Department of Urology, Tokyo Metropolitan Tama Geriatric Hospital.
authors.forename: Yoh
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ishimaru
authors.forename: Gaku
authors.initials: G
authors.lastname: Arai
authors.forename: Junko
authors.initials: J
authors.lastname: Aida
authors.forename: Yume
authors.initials: Y
authors.lastname: Okada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D018395:CA-19-9 Antigen / Q000096:biosynthesis* / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis* / Q000097:blood; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D007682:Kidney Pelvis; D008297:Male; D009378:Neoplasms, Multiple Primary; D009392:Nephrectomy; D014513:Ureter / Q000601:surgery
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen