title: Early plasmacytoid dendritic cell changes predict plasma HIV load rebound during primary infection.
abstract: During human immunodeficiency virus (HIV) infection, interruption of highly active antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here, the number of pDCs was measured by flow cytometry before, during, and after receipt of HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was evidenced between pDC counts after 1 month of HAART and mean plasma virus load after interruption of HAART (r2=0.85; Spearman's partial rho =-0.92; P=.03). pDC counts during treatment might help predict immune replication control after interruption of HAART.
authors.affiliation: Département de Maladies Infectieuses et Tropicales, Hôpital St. Antoine, Assistance Publique--Hopitaux de Paris, Universite Paris VI, Paris, France.
authors.forename: Jerome
authors.initials: J
authors.lastname: Pacanowski
authors.forename: Leyla
authors.initials: L
authors.lastname: Develioglu
authors.forename: Isabelle
authors.initials: I
authors.lastname: Kamga
authors.forename: Martine
authors.initials: M
authors.lastname: Sinet
authors.forename: Moïse
authors.initials: M
authors.lastname: Desvarieux
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
authors.forename: Anne
authors.initials: A
authors.lastname: Hosmalin
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D002452:Cell Count; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D014766:Viremia