title: Spatially selective T2 and T2 * measurement with line-scan echo-planar spectroscopic imaging.
abstract: Line-scan echo planar spectroscopic imaging (LSEPSI) is applied to quickly measure the T2 and T2* relaxation time constants in pre-selected 2D or 3D regions. Results from brain imaging studies at 3T suggest that the proposed method may prove valuable for both basic research (e.g., quantifying the changes of T2/T2* values in functional MRI with blood oxygenation level-dependent contrast) and clinical studies (e.g., measuring the T2' shortening due to iron deposition). The proposed spatially selective T2 and T2* mapping technique is especially well suited for studies, where T2/T2* quantification needs to be performed dynamically in a pre-selected 2D or 3D region.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Nan-kuei_Chen@hms.harvard.edu
authors.forename: Nan-kuei
authors.initials: NK
authors.lastname: Chen
authors.forename: Koichi
authors.initials: K
authors.lastname: Oshio
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: Panych
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Rybicki
authors.forename: Robert V
authors.initials: RV
authors.lastname: Mulkern
mesh_terms: D001921:Brain / Q000502:physiology*; D002560:Cerebrovascular Circulation; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans