title: [Malignant non-Hodgkin lymphoma presenting with Garcin's syndrome].
abstract: BACKGROUND
  R Garcin described progressive unilateral cranial nerve palsy in 1926. Garcin syndrome is characterized by progressive involvement of the cranial nerves culminating in total unilateral paralysis of all cranial nerves. Carcinoma of the skull base or ENT regions is the most common etiology.
  
  
  METHODS
  A 74-year-old man developed signs involving the left Vth (V2 and V3) cranial nerve then the VIth, VIIth and VIIIth cranial nerves and finally the IXth and Xth. MRI showed involvement of these cranial nerves with gadolinium uptake and involvement of the pons at the terminal phase. Careful ENT explorations failed to reveal a cause. The lymphocyte count was elevated in the cerebrospinal fluid. The patient died one year after diagnosis and the general autopsy was normal. The neuropathological studies led to the post-mortem diagnosis of type B non-Hodgkin lymphoma.
  
  
  CONCLUSIONS
  In patients with Garcin syndrome, lymphoma is a possible diagnosis when carcinoma of the ENT regions or of the skull bases are not present.
authors.affiliation: Laboratoire de Biologie Cellulaire, CHU, Angers.
authors.forename: F
authors.initials: F
authors.lastname: Letournel
authors.forename: P
authors.initials: P
authors.lastname: Lejeune
authors.forename: N
authors.initials: N
authors.lastname: Josselin
authors.forename: A
authors.initials: A
authors.lastname: Barthelaix
authors.forename: F
authors.initials: F
authors.lastname: Dubas
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D003389:Cranial Nerve Diseases / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D018655:Lymphocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010243:Paralysis / Q000000981:diagnostic imaging / Q000209:etiology*; D011877:Radionuclide Imaging; D013577:Syndrome