title: Unprecedented olefin-dependent histidine-kinase inhibitory of zerumbone ring-opening material.
abstract: Zerumbone ring-opening derivative, 4 (10E/10Z=3/2), inhibited autophosphorylation of the essential histidine-kinase YycG existing in Bacillus subtilis constituting a two-component system (TCS). Generation of 4E-form could be regulated chemically using the difference from the ring-opening reactivity of the precursor forming of 4 and pure 4E was isolated. The stereoisomer, 4E, showed main inhibition activity of autophosphorylation of YycG (IC(50)=63.5 microM).
authors.affiliation: Advanced Life Science, Graduate School of Agriculture, Kinki University, Nara 631-8505, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitayama
authors.forename: Risa
authors.initials: R
authors.lastname: Iwabuchi
authors.forename: Shu
authors.initials: S
authors.lastname: Minagawa
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Shiomi
authors.forename: John
authors.initials: J
authors.lastname: Cappiello
authors.forename: Seiji
authors.initials: S
authors.lastname: Sawada
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Utsumi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D000475:Alkenes / Q000737:chemistry* / Q000302:isolation & purification; D000071677:Histidine Kinase; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D011494:Protein Kinases / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D047428:Protein Kinase Inhibitors; D012717:Sesquiterpenes; C403304:zerumbone; D011494:Protein Kinases; D000071677:Histidine Kinase