Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data.
OBJECTIVE
Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus.


METHODS
The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content.


RESULTS
In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels.


CONCLUSIONS
The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.
Dormont
Didier
D
Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
Ricciardi
Kenneth G
KG
Tandé
Dominique
D
Parain
Karine
K
Menuel
Carole
C
Galanaud
Damien
D
Navarro
Soledad
S
Cornu
Philippe
P
Agid
Yves
Y
Yelnik
Jérôme
J
D000328:Adult; D000368:Aged; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007501:Iron / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology; D010300:Parkinson Disease / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013238:Stereotaxic Techniques / Q000706:statistics & numerical data*; D020531:Subthalamic Nucleus / Q000473:pathology*
D007501:Iron