The influence of autoantibodies to myeloperoxidase on neutrophil function and intracellular signaling.
Autoantibodies to myeloperoxidase (MPO) are associated with small vessel systemic vasculitis. Interactions of these autoantibodies with MPO target antigen, Fcgamma receptors and Beta2 integrins at the neutrophil surface, can set in train a sequence of intracellular signal transduction events that culminate with functional responses. These include a respiratory burst with release of superoxide ions, degranulation, cytokine release, enhanced adhesion and induction of an accelerated apoptotic program.
Williams
Julie
J
Division of Immunity and Infection, The Medical School, University of Birmingham, UK.
Hewins
Peter
P
Savage
Caroline
C
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D009195:Peroxidase / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase