Acute promyelocytic leukemia and HIV-1 infection: case report and review of the literature.
We report a 27-year-old man with HIV-1 infection who developed acute promyelocytic leukemia (APL) with a novel complex three-way chromosomal translocation t(15;16;17). Induction of remission and consolidation with all-trans-retinoic acid (ATRA)- and anthracycline-based chemotherapy was followed by maintenance therapy consisting of ATRA, 6-mercaptopurine (6-MP), and methotrexate (MTX). Highly active antiretroviral therapy (HAART) was continued with brief interruptions. He remains in complete remission 40 months after diagnosis.
Kudva
Ganesh C
GC
Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri 63110, USA. kudvagc@slu.edu
Maliekel
Kochurani
K
Richart
John M
JM
Batanian
Jacqueline R
JR
Grosso
Leonard E
LE
Sokol-Anderson
Marcia
M
Petruska
Paul J
PJ
D000328:Adult; D018943:Anthracyclines / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D015497:HIV-1; D018451:Homosexuality, Male; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage
D018943:Anthracyclines; D014212:Tretinoin; D015122:Mercaptopurine; D008727:Methotrexate