Serum lipids and hippocampal volume: the link to Alzheimer's disease?
The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High-density lipoprotein cholesterol, but not low-density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease.
Wolf
Henrike
H
Department of Psychiatry, University of Leipzig, Leipzig, Germany. henrike.wolf@neurotec.ki.se
Hensel
Anke
A
Arendt
Thomas
T
Kivipelto
Miia
M
Winblad
Bengt
B
Gertz
Hermann-Josef
HJ
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000473:pathology*; D000704:Analysis of Variance; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids