Introduction of the American/Asian genotype of dengue 2 virus into the Yucatan State of Mexico.
A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asian genotype; this is the first report of this genotype in the Yucatan State. The DEN-2 viruses of the American-Asian genotype have been associated with more severe disease outcomes. Thus, its introduction into the Yucatan State presents a serious problem to public health authorities. During this outbreak, DEN virus infection was confirmed in 18% (282 of 1,560) of the patients who presented with DEN-like symptoms. Of these, 87 (31%) patients met the World Health Organization criteria for dengue hemorrhagic fever, including two patients who died. The majority (77%) of the patients experienced secondary infections in this epidemic.
Loroño-Pino
María A
MA
Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Av. Itzáes No. 490 x 59, Centro, Merida, Yucatan, Mexico 97000.
Farfán-Ale
José A
JA
Zapata-Peraza
Alicia L
AL
Rosado-Paredes
Elsy P
EP
Flores-Flores
Luis F
LF
García-Rejón
Julián E
JE
Díaz
Francisco J
FJ
Blitvich
Bradley J
BJ
Andrade-Narváez
Manuel
M
Jiménez-Ríos
Eusebio
E
Blair
Carol D
CD
Olson
Ken E
KE
Black
William
W
Beaty
Barry J
BJ
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D003716:Dengue Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D019595:Severe Dengue / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D012720:Severity of Illness Index
D000914:Antibodies, Viral