Effect of chronic caffeine consumption on changes in locomotor activity of WAG/G and Fischer-344 rats induced by nicotine, ethanol, and morphine.
We studied the effect of single treatment with nicotine, ethanol, and morphine on locomotor activity of WAG/G and Fischer-344 rats chronically drinking caffeine solution. In Fischer-344 rats receiving caffeine locomotor activity in the open-field test was much lower than in animals drinking water, while in WAG/G rats no differences in locomotor activity were found. Chronic caffeine intake increased rat sensitivity to the stimulating effect of nicotine and ethanol, but decreased their sensitivity to the depressant effect of morphine. Chronic caffeine treatment most significantly modulated the effects of nicotine, ethanol, and morphine in Fischer-344 rats.
Sudakov
S K
SK
National Research Center for Narcology, Russian Ministry of Health, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow. s-sudakov@mtu-net.ru
Rusakova
I V
IV
Medvedeva
O F
OF
D000428:Alcohol Drinking; D000818:Animals; D001522:Behavior, Animal; D002110:Caffeine / Q000494:pharmacology*; D005247:Feeding Behavior; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains
D002110:Caffeine; D009538:Nicotine; D009020:Morphine