title: Hazelnut oil administration reduces aortic cholesterol accumulation and lipid peroxides in the plasma, liver, and aorta of rabbits fed a high-cholesterol diet.
abstract: Hazelnut oil (HO) is rich in monounsaturated fatty acids and antioxidants. We wanted to investigate the effect of HO on lipid levels and prooxidant-antioxidant status in rabbits fed a high-cholesterol (HC) diet. An HC diet caused significant increases in lipids and lipid peroxide levels in the plasma, liver, and aorta together with histopathological atherosclerotic changes in the aorta. Glutathione levels, glutathione peroxidase, and glutathione transferase activities decreased significantly, but superoxide dismutase activity and vitamin E and C levels remained unchanged in the livers of rabbits following HC diet. HO supplementation reduced plasma, liver, and aorta lipid peroxide levels and aorta cholesterol levels together with amelioration in atherosclerotic lesions in the aortas of rabbits fed an HC diet, without any decreasing effect on cholesterol levels in the plasma or liver. HO did not alter the antioxidant system in the liver in the HC group. Our findings indicate that HO reduced oxidative stress and cholesterol accumulation in the aortas of rabbits fed an HC diet.
authors.affiliation: Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, 34093 Capa-Istanbul, Turkey.
authors.forename: Aydan
authors.initials: A
authors.lastname: Hatipoğlu
authors.forename: Oznur
authors.initials: O
authors.lastname: Kanbağli
authors.forename: Jale
authors.initials: J
authors.lastname: Balkan
authors.forename: Mutlu
authors.initials: M
authors.lastname: Küçük
authors.forename: Uğur
authors.initials: U
authors.lastname: Cevikbaş
authors.forename: Gülçin
authors.initials: G
authors.lastname: Aykaç-Toker
authors.forename: Hakan
authors.initials: H
authors.lastname: Berkkan
authors.forename: Müjdat
authors.initials: M
authors.lastname: Uysal
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D001161:Arteriosclerosis / Q000188:drug therapy / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D031211:Corylus / Q000737:chemistry*; D004036:Diet, Atherogenic; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D010938:Plant Oils; D014810:Vitamin E; D002784:Cholesterol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione