Impact of antimicrobial exposure and beta-lactamase-producing bacteria on salivary beta-lactamase activity in infancy.
Beta-lactamase production by oral bacteria is common in infancy and is associated with use of antimicrobial agents in infants. The present longitudinal study aimed to examine the frequency of salivary beta-lactamase activity (SbetaA), to compare SbetaA with the presence of beta-lactamase-producing (beta+) aerobic and anaerobic species in saliva, and to estimate the impact of antimicrobial exposure on the emergence of SbetaA in healthy infants during their first year of life. At 6 months, SbetaA was detected in 46% infants; 89% SbetaA-positive infants and 55% SbetaA-negative infants harboured beta+ species at this time (OR 7.08; CI 1.31-38.34). At 12 months, SbetaA was detected in 54% infants. Exposure to antimicrobials during the first year of life increased the risk (OR 2.60; CI 0.72-9.36) of having SbetaA.
Nyfors
S
S
Department of Microbiology, Anaerobe Reference Laboratory, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland. susannyforsuk@aol.com
Syrjänen
R
R
Könönen
E
E
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006088:Gram-Negative Aerobic Bacteria / Q000201:enzymology*; D006089:Gram-Negative Anaerobic Bacteria / Q000201:enzymology*; D006801:Humans; D007223:Infant; D012469:Salivary Glands / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases