title: Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
abstract: Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Xihong
authors.initials: X
authors.lastname: Wang
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Sun
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Lin
authors.forename: Hsi-Jung
authors.initials: HJ
authors.lastname: Yu
authors.forename: Ming-Jaw
authors.initials: MJ
authors.lastname: Don
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D011960:Receptors, Estrogen / Q000096:biosynthesis; D027561:Salvia miltiorrhiza
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D011753:Pyrones; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; C494351:neotanshinlactone