title: Kahiricosides II-V, cycloartane glycosides from an Egyptian collection of Astragalus kahiricus.
abstract: Four cycloartane-type saponins, kahiricosides II-V (1-4), were isolated from the aerial parts of Astragalus kahiricus of Egyptian origin. Their structures were established as 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-beta-D-glucopyranoside, 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-(2'-O-acetyl)-beta-D-glucopyranoside, 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-(6'-O-acetyl)-beta-D-glucopyranoside, and 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-beta-D-glucopyranosyl-27-O-beta-D-glucopyranoside based on chemical and spectral evidences. All compounds exhibited very weak cytotoxicity against the A2780 ovarian cancer cell line.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, 3111 Hahn Hall, MC 0212, Blacksburg, VA 24061-0212, USA.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Radwan
authors.forename: Nadia A
authors.initials: NA
authors.lastname: El-Sebakhy
authors.forename: Aya M
authors.initials: AM
authors.lastname: Asaad
authors.forename: Soad M
authors.initials: SM
authors.lastname: Toaima
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D027883:Astragalus Plant / Q000737:chemistry*; D045744:Cell Line, Tumor; D004534:Egypt; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry; D014315:Triterpenes / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D014315:Triterpenes; C495033:kahiricoside II; C495030:kahiricoside III; C495031:kahiricoside IV; C495032:kahiricoside V