title: [Effect of jianxin pinglu pill on arrhythmia and aquaporin 4 expression in rats with myocardial ischemia/reperfusion injury].
abstract: OBJECTIVE
  To explore the effect of jianxin pinglu pill (JPP) on arrhythmia and aquaporin 4 (AQP4) in rats with myocardial ischemia/reperfusion (I/R) injury.
  
  
  METHODS
  The effects of JPP on arrhythmia, mortality and AQP4 on I/R injured rats model induced by blocking left coronary artery were observed using II lead of ECG, HE stain and AQP4 immunohistochemical stain.
  
  
  RESULTS
  JPP showed significant effect in lowering the arrhythmia occurrence and mortality, reducing myocardial ischemic edema and injury, strengthening AQP4 expression in myocardial tissue.
  
  
  CONCLUSIONS
  JPP has the effect of preventing I/R induced arrhythmia, it might be related with its action in up-regulating AQP4 expression level in myocardium and reducing the intracellular edema.
authors.affiliation: Department of Internal Medicine, Shenzhen Municipal Hospital of TCM, Guangdong (518033). hxp-szzy@163.net
authors.forename: Xu-ping
authors.initials: XP
authors.lastname: He
authors.forename: Dong-feng
authors.initials: DF
authors.lastname: Chen
authors.forename: Jian-hong
authors.initials: JH
authors.lastname: Zheng
authors.forename: Shaohui
authors.initials: S
authors.lastname: Du
authors.forename: Bin
authors.initials: B
authors.lastname: Deng
authors.forename: Shangbin
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D051401:Aquaporin 4; D020346:Aquaporins / Q000032:analysis / Q000096:biosynthesis*; D001145:Arrhythmias, Cardiac / Q000378:metabolism* / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000150:complications* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D000889:Anti-Arrhythmia Agents; C496032:Aqp4 protein, rat; D051401:Aquaporin 4; D020346:Aquaporins; D004365:Drugs, Chinese Herbal