title: Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation.
abstract: Application of nucleus pulposus to nerve root generates radicular pain. We demonstrated that these animals showed allodynia for 2 weeks, and cyclooxygenase-2 (COX-2) immunoreactivities were up-regulated in the spinal dorsal horn. COX-2 immunoreactivities were shown in neurons; however, they were not in astrocytes. Intrathecal administration of an antibody to COX-2 decreased allodynia. Our results suggest that COX-2 in spinal cord might be a target for treatment of patients with nerve root pain caused by lumbar disk herniation.
  
  
  CONCLUSIONS
  Neural COX-2 might mediate nerve root pain in the spinal cord caused by lumbar disk herniation in rats.
authors.affiliation: Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University School of Medicine, Chiba University, Chiba, Japan. sohtori@faculty.chiba-u.jp
authors.forename: Seiji
authors.initials: S
authors.lastname: Ohtori
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yasuchika
authors.initials: Y
authors.lastname: Aoki
authors.forename: Hideo
authors.initials: H
authors.lastname: Doya
authors.forename: T
authors.initials: T
authors.lastname: Ozawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Saito
authors.forename: Hideshige
authors.initials: H
authors.lastname: Moriya
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D051546:Cyclooxygenase 2; D004195:Disease Models, Animal; D005727:Ganglia, Spinal / Q000378:metabolism; D007278:Injections, Spinal; D007405:Intervertebral Disc Displacement / Q000378:metabolism*; D007527:Isoenzymes / Q000276:immunology / Q000378:metabolism*; D008159:Lumbar Vertebrae; D008297:Male; D010146:Pain / Q000378:metabolism*; D020671:Posterior Horn Cells / Q000201:enzymology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000276:immunology / Q000378:metabolism*; D011843:Radiculopathy / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000906:Antibodies; D007527:Isoenzymes; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases