title: Strategies for RNA folding and assembly.
abstract: RNA is structurally very flexible, which provides the basis for its functional diversity. An RNA molecule can often adopt different conformations, which enables the regulation of its function through folding. Proteins help RNAs reach their functionally active conformation by increasing their structural stability or by chaperoning the folding process. Large, dynamic RNA-protein complexes, such as the ribosome or the spliceosome, require numerous proteins that coordinate conformational switches of the RNA components during assembly and during their respective activities.
authors.affiliation: Max F. Perutz Laboratories, Department of Microbiology and Genetics, University of Vienna, Austria. renee.schroeder@univie.ac.at
authors.forename: Renée
authors.initials: R
authors.lastname: Schroeder
authors.forename: Andrea
authors.initials: A
authors.lastname: Barta
authors.forename: Katharina
authors.initials: K
authors.lastname: Semrad
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000595:Amino Acid Sequence; D001483:Base Sequence; D002384:Catalysis; D018832:Molecular Chaperones / Q000737:chemistry; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D012313:RNA / Q000737:chemistry*; D016337:RNA, Catalytic / Q000737:chemistry; D017381:Spliceosomes / Q000737:chemistry
chemical_list: D018832:Molecular Chaperones; D011506:Proteins; D016337:RNA, Catalytic; D012313:RNA; D000255:Adenosine Triphosphate