Transpupillary thermotherapy (TTT) of occult choroidal neovascularization: a retrospective, noncomparative case series of fifty-seven eyes.
OBJECTIVE
To evaluate the efficacy of transpupillary thermotherapy (TTT) for the treatment of occult choroidal neovascularization.


METHODS
A retrospective, noncomparative case series of 57 eyes of 52 patients who presented with occult subfoveal CNV and were treated with TTT.


RESULTS
83% of eyes were either stable (+/- one line) or showed improvement in visual acuity. 83% of eyes showed stabilization of their exudative process after one TTT treatment as evidenced by resorption of subretinal and/or intraretinal exudate or hemorrhage. Nine percent of eyes developed classic CNV during the mean follow-up time of ten months.


CONCLUSIONS
TTT appears to stabilize the exudative process in eyes with occult CNV. A prospective, sham-controlled, randomized study (TTT4CNV Clinical Trial) is currently underway to directly compare TTT to the natural history of occult CNV.
Park
C H
CH
Ophthalmology Department, New England Eye Center, Tufts University School of Medicine, Boston, MA, USA.
Duker
J S
JS
Mainster
M A
MA
Puliafito
C A
CA
Reichel
E
E
D000368:Aged; D020256:Choroidal Neovascularization / Q000628:therapy*; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D011680:Pupil; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity