Synthesis of pathogen inactivating nucleic acid intercalators.
A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by several logarithmic decades.
Csuk
René
R
Institut für Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Strasse 2, 06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de
Barthel
Alexander
A
Brezesinski
Thorsten
T
Raschke
Christian
C
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism; D004492:Edetic Acid / Q000737:chemistry; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007501:Iron / Q000378:metabolism; D017909:Levivirus / Q000187:drug effects*; D009696:Nucleic Acids / Q000187:drug effects*
D000166:Acridines; D000998:Antiviral Agents; D007364:Intercalating Agents; D009696:Nucleic Acids; D004492:Edetic Acid; D007501:Iron; D001205:Ascorbic Acid