Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.
Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life prolonged the lifespan and markedly reduced mortality of animals aged 1.5-2 years. Neuronol inhibited the development of spontaneous tumors, primarily lymphomas, and significantly prolonged lifespan in mice with tumors. Long-term treatment with Neuronol had no pathological side effects. Our experiments demonstrated geroprotective and anticarcinogenic activity of Neuronol and safety of its long-term use.
Popovich
I G
IG
Department of Carcinogenesis and Oncogerontology, N N Petrov Institute of Oncology, Ministry of Health of Russian Federation, Restock.
Zabezhinskii
M A
MA
Anisimov
V N
VN
Kovalenko
A L
AL
Petrov
A Yu
AY
Semenchenko
A V
AV
Yashin
A I
AI
D000375:Aging / Q000473:pathology*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000009:adverse effects / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D008136:Longevity / Q000187:drug effects*; D008223:Lymphoma / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D013386:Succinates / Q000009:adverse effects / Q000494:pharmacology*; D019802:Succinic Acid / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; C493850:Neuronol; D013386:Succinates; D019802:Succinic Acid