title: Relation between injected volume and optical parameters in refilled isolated porcine lenses.
abstract: OBJECTIVE
  This study was performed to elucidate the correlation between added lens refill material and enhanced lens power as well as the correlation between lens refilling volume and accommodative amplitude as determined by equatorial stretching of ex vivo refilled pigs' lenses.
  
  
  METHODS
  Nine porcine lenses were refilled with increasing amounts of silicone oil. After each refill step, the lens power, the lens power change, and the lens thickness were measured both in the relaxed state and with a 3-mm larger ciliary body diameter. In addition, the spherical aberration of the refilled lenses was also quantified.
  
  
  RESULTS
  Injection of 0.04 mL silicone material into the relaxed lens enhanced the lens power by 1 D. A 0.54-mm increase of the lens thickness in relaxed lenses added 1 D to the lens power. Increasing the lens refilling volume decreased the lens power changes measured at 3-mm ciliary body stretch. Spherical aberration was positive in the refilled lenses and increased with increasing lens refilling volume.
  
  
  CONCLUSIONS
  The correlation found between the refilling volume and the lens power (0.04 mL D(-1)), as well as the correlation between the lens thickness and the lens power (0.54 mm D(-1)), might be important factors to be controlled in conjunction with surgery, as these also determine the lens power in the presence of this refill material. An increasing lens filling volume is associated with decreasing accommodative amplitude. The positive spherical aberration of refilled porcine lenses presents a sharp contrast to the negative aberration of natural pigs' lenses. Different lens contours and the transition from a gradient to a homogeneous refractive index might be responsible for this change in spherical aberration.
authors.affiliation: Applied Research Laboratory, Pfizer Groningen, van Swietenlaan, Groningen, The Netherlands. s.a.koopmans@ohk.azg.nl
authors.forename: Steven A
authors.initials: SA
authors.lastname: Koopmans
authors.forename: Thom
authors.initials: T
authors.lastname: Terwee
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Haitjema
authors.forename: Henk
authors.initials: H
authors.lastname: Deuring
authors.forename: Sonja
authors.initials: S
authors.lastname: Aarle
authors.forename: Aart C
authors.initials: AC
authors.lastname: Kooijman
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology; D000375:Aging / Q000502:physiology; D000818:Animals; D002924:Ciliary Body / Q000033:anatomy & histology; D004334:Drug Administration Schedule; D007903:Lens Capsule, Crystalline / Q000601:surgery; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000502:physiology* / Q000601:surgery; D055095:Optics and Photonics; D011305:Presbyopia / Q000503:physiopathology / Q000601:surgery; D012029:Refraction, Ocular / Q000502:physiology; D012827:Silicone Oils / Q000008:administration & dosage*; D013552:Swine
chemical_list: D012827:Silicone Oils