title: [Disseminated melanoma treatment].
abstract: Disseminated melanoma is an incurable disease whose prognosis has remained unchanged over the past 20 years. To date, no consensus treatment has emerged. No treatment strategy has proved superior to dacarbazine (Deticene) monochemotherapy that remains considered as the reference treatment for this disease. Both multidrug chemotherapy and biochemotherapy have provided disappointing results, with poorer quality of life and no survival benefit for the patients. Other treatment approaches, particularly immunotherapy, remain to be investigated in clinical trials.
authors.affiliation: Centre Léon-Bérard, 28, rue Laennec, Lyon 69008. neidhard@lyon.fnclcc.fr
authors.forename: Eve-Marie
authors.initials: EM
authors.lastname: Neidhardt-Bérard
authors.forename: Sylvie
authors.initials: S
authors.lastname: Négrier
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D003606:Dacarbazine / Q000627:therapeutic use*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine