title: Antimicrobial drug use and methicillin-resistant Staphylococcus aureus, Aberdeen, 1996-2000.
abstract: Similar to many hospitals worldwide, Aberdeen Royal Infirmary has had an outbreak of methicillin-resistant Staphylococcus aureus (MRSA). In this setting, the outbreak is attributable to two major clones. The relationships between antimicrobial use and MRSA prevalence were analyzed by time-series analysis. From June 1997 to December 2000, dynamic, temporal relationships were found between monthly %MRSA and previous %MRSA, macrolide use, third-generation cephalosporin use, and fluoroquinolone use. This study suggests that use of antimicrobial drugs to which the MRSA outbreak strains are resistant may be an important factor in perpetuating the outbreak. Moreover, this study confirmed the ecologic effect of antimicrobial drug use (i.e., current antimicrobial use) may have an effect on resistance in future patients. Although these results may not be generalized to other hospitals, they suggest new directions for control of MRSA, which has thus far proved difficult and expensive.
authors.affiliation: Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Dominique L
authors.initials: DL
authors.lastname: Monnet
authors.forename: Fiona M
authors.initials: FM
authors.lastname: MacKenzie
authors.forename: José Maria
authors.initials: JM
authors.lastname: López-Lozano
authors.forename: Arielle
authors.initials: A
authors.lastname: Beyaert
authors.forename: Máximo
authors.initials: M
authors.lastname: Camacho
authors.forename: Rachel
authors.initials: R
authors.lastname: Wilson
authors.forename: David
authors.initials: D
authors.lastname: Stuart
authors.forename: Ian M
authors.initials: IM
authors.lastname: Gould
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D006761:Hospitals; D006801:Humans; D016106:Methicillin Resistance; D015995:Prevalence; D012606:Scotland / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents