title: Formation of a stable 14-helix in short oligomers of furanoid cis-beta-sugar-amino acid.
abstract: Oligomers of a new class of sugar amino acids (SAA) using a xylofuranoic acid has been shown to generate a robust 14-helix. The design involved the use of xylofuranose with a cis arrangement between the amine and carboxyl groups to promote the adoption of a 14-helix instead of a mixed 12/10-helix observed in a sugar oligomer using a ribofuranoic acid and beta-Ala. The observation of a stable right-handed 14-helix in a cis-SAA is unprecedented.
authors.affiliation: Indian Institute of Chemical Technology, Hyderabad 500 007, India. srivaric@iict.res.in
authors.forename: Srivari
authors.initials: S
authors.lastname: Chandrasekhar
authors.forename: Marepally Srinivasa
authors.initials: MS
authors.lastname: Reddy
authors.forename: Bharatam
authors.initials: B
authors.lastname: Jagadeesh
authors.forename: Anabathula
authors.initials: A
authors.lastname: Prabhakar
authors.forename: Mallem H V
authors.initials: MH
authors.lastname: Ramana Rao
authors.forename: Bulusu
authors.initials: B
authors.lastname: Jagannadh
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000606:Amino Sugars / Q000737:chemistry*; D002942:Circular Dichroism; D005663:Furans / Q000737:chemistry*; D006860:Hydrogen Bonding; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013816:Thermodynamics
chemical_list: D000596:Amino Acids; D000606:Amino Sugars; D005663:Furans; D009842:Oligopeptides