Platelet function, coagulopathy, and impaired fibrinolysis in diabetes.
Diabetes and the metabolic syndrome, including insulin resistance, that underlies it are hyper-coagulable states. Increased platelet reactivity,augmented activity of the coagulation system,and impaired fibrinolysis are characteristic and understood to a remarkable extent. In aggregate,these derangements contribute to accelerated atherosclerosis, premature coronary artery dis-ease, and a profound toll from both.
Sobel
Burton E
BE
Department of Medicine, University of Vermont, Colchester Research Facility, 208 South Park Drive, Colchester, VT 05446, USA. burt.sobel@vtmednet.org
Schneider
David J
DJ
D000818:Animals; D001779:Blood Coagulation Factors / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D019851:Thrombophilia / Q000097:blood / Q000503:physiopathology*
D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1