Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.
A series of tetrahydroisoquinolines has yielded potent MT(2) receptor antagonists, which are selective versus the MT(1) receptor.
Karageorge
George N
GN
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. karageog@bms.com
Bertenshaw
Stephen
S
Iben
Lawrence
L
Xu
Cen
C
Sarbin
Nathan
N
Gentile
Anthony
A
Dubowchik
Gene M
GM
D006801:Humans; D011485:Protein Binding / Q000502:physiology; D044123:Receptor, Melatonin, MT2 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D044005:Tetrahydroisoquinolines / Q000737:chemistry* / Q000378:metabolism*
D044123:Receptor, Melatonin, MT2; D044005:Tetrahydroisoquinolines