Primary cardiac angiosarcoma with systemic metastases; a case report and review of the literature.
Angiosarcoma is a relatively uncommon primary malignant tumor of the heart derived from the endothelial cells. The authors report a case of primary cardiac angiosarcoma of the right atrium with pulmonary, hepatic, cerebellar and bony metastases in a 46-year-old man who clinically presented as pulmonary hemorrhage. The patient's occupational history had occasional exposure to polyvinyl chloride. The autopsy examination of the cardiac angiosarcoma characterized macroscopically by a right atrial tumor and histologically by anastomosing vascular channels and minute atypical pleomorphic endothelial cells. Immunohistological stainings were positive CD31, CD34 and focal positive factor VII-related antigen. Clinical and pathologic features with briefly reviewed relevant literatures are discussed This is the first reported description in the literature of a primary cardiac angiosarcoma with systemic metastases to multiple organs in Thailand.
Larbcharoensub
Noppadol
N
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.
Singhsnaeh
Arunee
A
Leelachaikul
Paisan
P
D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006338:Heart Neoplasms / Q000473:pathology*; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged