Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation.
During haematogenous metastasis, cancer cells migrate to the vasculature and interact with platelets resulting in tumour cell-induced platelet aggregation (TCIPA). We review: 1. The biological and clinical significance of TCIPA; 2. Molecular mechanisms involved in platelet aggregation by cancer cells; 3. Strategies for pharmacological regulation of these interactions. We conclude that pharmacological regulation of platelet-cancer cell interactions may reduce the impact of TCIPA on cancer biology.
Jurasz
Paul
P
Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas-Houston, Houston, TX, USA.
Alonso-Escolano
David
D
Radomski
Marek W
MW
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology
D000970:Antineoplastic Agents; D010975:Platelet Aggregation Inhibitors