title: The pharmacology of CGRP-responsive receptors in cultured and transfected cells.
abstract: Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however, this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.
authors.affiliation: School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
authors.forename: D L
authors.initials: DL
authors.lastname: Hay
authors.forename: A C
authors.initials: AC
authors.lastname: Conner
authors.forename: S G
authors.initials: SG
authors.lastname: Howitt
authors.forename: M A
authors.initials: MA
authors.lastname: Takhshid
authors.forename: J
authors.initials: J
authors.lastname: Simms
authors.forename: K
authors.initials: K
authors.lastname: Mahmoud
authors.forename: D R
authors.initials: DR
authors.lastname: Poyner
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002460:Cell Line; D006801:Humans; D018003:Receptors, Calcitonin / Q000378:metabolism*; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism*; D014162:Transfection
chemical_list: D018003:Receptors, Calcitonin; D018015:Receptors, Calcitonin Gene-Related Peptide; D018000:Receptors, Peptide; D015740:Calcitonin Gene-Related Peptide