Outcome of in vitro fertilization-embryo transfer according to age in poor responders with elevated baseline serum follicle stimulation hormone using minimal or no gonadotropin stimulation.
OBJECTIVE
To determine whether decreased ovarian reserve or advancing age are more associated with decreased oocyte quality.


METHODS
Women with baseline serum follicle stimulating hormone (FSH) > 12 mIU/ml who demonstrated previous poor response to controlled ovarian hyperstimulation (COH) had oocyte retrieval without gonadotropin stimulation in natural cycles or with minimal stimulation (maximum 75 IU gonadotropins) without agonists or antagonists were evaluated following in vitro fertilization-embryo transfer.


RESULTS
The ongoing/delivered pregnancy rates were 27.3%, 30.8%, 21.7%, and 0.0%, respectively, with a mean of 1.06 embryos per transfer. The implantation rates were 33.3%, 28.6%, 14.7%, and 6.0%. Approximately half of the retrievals resulted in failed fertilization.


CONCLUSIONS
Using these minimal or no drug COH regimens in a difficult group of women, age was found to be a more adverse infertility factor than elevated serum FSH.
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M L
ML
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper/Hospital University Medical Center, Department of Obstetrics and Gynecology, Camden, NJ, USA.
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J H
JH
Wilson
C
C
Choe
J K
JK
Krotec
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J
D000328:Adult; D000367:Age Factors; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D009865:Oocytes / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D020858:Tissue and Organ Harvesting; D014481:United States
D006062:Gonadotropins; D005640:Follicle Stimulating Hormone