Agnogenic myeloid metaplasia in an ovarian steroid cell tumor with virilization: a case report.
BACKGROUND
Extramedullary hematopoiesis in patients without hematologic disorders is very rare and has apparently never been described previously in association with an ovarian steroid cell tumor.


METHODS
An 18-year-old woman was admitted to our clinic due to primary amenorrhea. the On examination she had significant facial hirsutism, clitoromegaly and and Adam's apple. The serum level of testosterone was elevated. A 7-cm, right ovarian mass was enucleated during laparotomy. Histology revealed a steroid cell tumor with foci of myeloid metaplasia; bony trabecula formation was present. There was no evidence of hematologic or systemic disease. The hormone values became normal 1 month postoperatively.


CONCLUSIONS
This report describes a patient with agnogenic myeloid metaplasia in an ovarian steroid cell tumor with virilization; this association was not previously reported.
Huang
Ching-Wen
CW
Department of Pathology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan, Taiwan.
Hsueh
Swei
S
Chang
Ming-Yang
MY
D000293:Adolescent; D005260:Female; D006801:Humans; D007813:Laparotomy / Q000379:methods; D007984:Leydig Cell Tumor / Q000150:complications / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D055728:Primary Myelofibrosis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome; D014770:Virilism / Q000209:etiology* / Q000473:pathology