title: Interferon treatment of multiple pulmonary malignancies associated with papilloma virus.
abstract: Over a period of four years, beginning in spring 1988, a previously healthy man developed a primary squamous cell carcinoma of the tonsil, treated with radiotherapy, followed by 10 distinct, primary bronchial squamous cell carcinomas. Four of the cancers were surgically resected, all of which were positive by hybridization for human papilloma virus (type 16). Following the institution of alpha interferon, three smaller lesions disappeared and a larger one shrank in size, facilitating surgical resection. Over the following seven years no new ones have appeared. The finding of papilloma virus in malignancies should prompt consideration of antiviral therapy.
authors.affiliation: University of Alberta, Edmonton. stephen.aaron@ualberta.ca
authors.forename: S
authors.initials: S
authors.lastname: Aaron
authors.forename: E
authors.initials: E
authors.lastname: Wong
authors.forename: D
authors.initials: D
authors.lastname: Tyrrell
authors.forename: M
authors.initials: M
authors.lastname: Duggan
authors.forename: E
authors.initials: E
authors.lastname: Vallieres
authors.forename: L
authors.initials: L
authors.lastname: Jewell
authors.forename: B
authors.initials: B
authors.lastname: Romanowski
authors.forename: Patient John
authors.initials: PJ
authors.lastname: Doe
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D001984:Bronchial Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000821:virology*; D002294:Carcinoma, Squamous Cell / Q000628:therapy / Q000821:virology*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008168:Lung / Q000473:pathology; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000188:drug therapy; D014067:Tonsillar Neoplasms / Q000532:radiotherapy / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D016898:Interferon-alpha