Expression of 5-HT3A receptors in cells of the immune system.
There is evidence from both human and animal research that 5-hydroxytryptamine3 (5-HT3) receptor antagonists, particularly tropisetron, exert analgesic and antiinflammatory effects. However, the underlying mechanisms of these effects including the expression of 5-HT3 receptors in cells of the immune system have not yet been investigated in detail. Therefore, we investigated the expression of the 5-HT3A receptor in primary human monocytes, chondrocytes, T-cells, dendritic cells, and synovial tissue. We found that 5-HT3A receptors are expressed in monocytes, chondrocytes, T-cells, and synovial tissue but not in dendritic cells. Our data show that 5-HT3A receptors are widely expressed in cells of the immune system and that they might play an important role in inflammatory events and in the observed antiphlogistic effects of 5-HT3 receptor antagonists.
Fiebich
B L
BL
Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany. bernd.fiebich@klinikum.uni-freiburg.de
Akundi
R S
RS
Seidel
M
M
Geyer
V
V
Haus
U
U
Müller
W
W
Stratz
T
T
Candelario-Jalil
E
E
D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000502:physiology; D009000:Monocytes / Q000276:immunology; D044406:Receptors, Serotonin, 5-HT3 / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology
D044406:Receptors, Serotonin, 5-HT3