title: Desmoplastic infantile ganglioglioma: a rare tumor with an unusual presentation.
abstract: Desmoplastic infantile ganglioglioma (World Health Organization grade I) is a rare neoplasm. Despite their common large size and spectacular radiologic and histologic features, the prognosis after surgical resection is good. We present a new case of this tumor in a 14-month-old boy with a recent history of intracranial hypertension. Magnetic resonance imaging revealed a large tumor involving the left collateral trigone with dilatation of the lateral ventricles. Surgery revealed two separate solid tumors: one in the left falco-tentorial region and the other in the left rolandic area. Microscopic examination showed a proliferation of neoplastic astrocytes in reticulin-rich desmoplastic stroma associated with scattered ganglion cells. One year after surgery follow-up magnetic resonance imaging did not show tumor progression.
authors.affiliation: Department of Pathology, Centre Hospitalier Universitaire de Saint-Etienne, Cedex, France.
authors.forename: Abir
authors.initials: A
authors.lastname: Khaddage
authors.forename: Marie Laure
authors.initials: ML
authors.lastname: Chambonniere
authors.forename: Alan L
authors.initials: AL
authors.lastname: Morrison
authors.forename: Dominique
authors.initials: D
authors.lastname: Allard
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Dumollard
authors.forename: Basile
authors.initials: B
authors.lastname: Pasquier
authors.forename: Michel
authors.initials: M
authors.lastname: Péoc'h
mesh_terms: D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018303:Ganglioglioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D009367:Neoplasm Staging; D009778:Occipital Lobe / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor