Tissue responses to thermally-responsive hydrogel nanoparticles.
Thermally-responsive hydrogel nanoparticles of poly(N-isopropylacrylamide) (PNIPAM) and hydroxypropyl cellulose (HPC) have been synthesized. The particle size has been correlated to surfactant concentration and polymer concentration using dynamic laser light scattering techniques. The tissue compatibility of these hydrogel nanoparticles has been evaluated by comparing with poly-L-lactic acid and polystyrene nanoparticles using a mouse implantation model. Our results suggested that both PNIPAM and HPC nanoparticles triggered lesser inflammatory and fibrotic responses among all nanoparticles tested. It is likely that these hydrogel nanoparticles may be suitable for tissue augmentation or drug-delivery devices.
Weng
Hong
H
Biomedical Engineering Program, University of Texas at Arlington, PO Box 19138, Arlington, TX 76019, USA.
Zhou
Jun
J
Tang
Liping
L
Hu
Zhibing
Z
D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004343:Drug Implants; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008422:Materials Testing; D051379:Mice; D049329:Nanostructures; D010316:Particle Size; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
D000180:Acrylic Resins; D001672:Biocompatible Materials; D004343:Drug Implants; D020100:Hydrogels; C052970:poly-N-isopropylacrylamide; D002482:Cellulose; C008079:hydroxypropylcellulose