title: Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.
abstract: A series of tetrahydroisoquinolines has yielded potent MT(2) receptor antagonists, which are selective versus the MT(1) receptor.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. karageog@bms.com
authors.forename: George N
authors.initials: GN
authors.lastname: Karageorge
authors.forename: Stephen
authors.initials: S
authors.lastname: Bertenshaw
authors.forename: Lawrence
authors.initials: L
authors.lastname: Iben
authors.forename: Cen
authors.initials: C
authors.lastname: Xu
authors.forename: Nathan
authors.initials: N
authors.lastname: Sarbin
authors.forename: Anthony
authors.initials: A
authors.lastname: Gentile
authors.forename: Gene M
authors.initials: GM
authors.lastname: Dubowchik
mesh_terms: D006801:Humans; D011485:Protein Binding / Q000502:physiology; D044123:Receptor, Melatonin, MT2 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D044005:Tetrahydroisoquinolines / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D044123:Receptor, Melatonin, MT2; D044005:Tetrahydroisoquinolines