title: Management of children with infection-associated persistent diarrhea.
abstract: Diarrhea is the leading cause of death in children younger than 5 years of age; persistent diarrhea accounts for 30 to 50 percent of those deaths in developing countries. Malnutrition, immunosuppression, young age, and an increase in the preceding diarrhea burdens are risk factors for the development of persistent diarrhea. Although many viruses, bacteria, and parasites can produce persistent diarrhea, enteropathogenic Escherichia coli , enteroaggregative E. coli, Giardia, Cryptosporidium , and Cyclospora are the most important of these agents. With currently available tests, identifying a specific cause usually is difficult. Newer sensitive molecular tests must be used for studying the epidemiology of persistent diarrhea in children. Management includes rehydration, adequate diet, micronutrient supplementation, and antimicrobials. Persistent diarrhea seriously affects nutritional status, growth, and intellectual function. Meeting these challenges is profoundly important, particularly in developing countries.
authors.affiliation: University of Texas Medical School at Houston, Department of Pediatrics, Pediatric Infectious Diseases Division, 6431 Fannin, JFB 1.739, Houston, TX 77030, USA. Theresa.J.Ochoa@uth.tmc.edu
authors.forename: Theresa J
authors.initials: TJ
authors.lastname: Ochoa
authors.forename: Eduardo
authors.initials: E
authors.lastname: Salazar-Lindo
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Cleary
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D002675:Child, Preschool; D002908:Chronic Disease; D003906:Developing Countries; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D005440:Fluid Therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018977:Micronutrients / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D018977:Micronutrients