Dendritic h channelopathy in epileptogenesis.
Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells.
Dyhrfjeld-Johnsen
Jonas
J
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Soltesz
Ivan
I
D000818:Animals; D003712:Dendrites / Q000502:physiology*; D018728:Entorhinal Cortex / Q000166:cytology / Q000503:physiopathology; D004827:Epilepsy / Q000503:physiopathology*; D007473:Ion Channels / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D017966:Pyramidal Cells / Q000503:physiopathology*; D051381:Rats
D007473:Ion Channels