title: Genetic relatedness of antibiotic-resistant pneumococci isolated during case clusters.
abstract: Multilocus sequence typing of Streptococcus pneumoniae associated with two case clusters of disease is reported here for the first time. Isolates from the first cluster were serotype 19F, resistant to penicillin and erythromycin, and were characterized as ST 320. Isolates from the second cluster were serogroup 4, resistant to ciprofloxacin, and were characterized as ST 206. Therefore, the isolates from these clusters were antibiotic-resistant, of serotypes infrequently isolated, and of uncommon sequence types.
authors.affiliation: Scottish Meningococcus and Pneumococcus Reference Laboratory, Department of Microbiology, Stobhill Hospital, Balornock Road, Glasgow G21 3UW, UK 2Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Clarke
authors.affiliation: Scottish Meningococcus and Pneumococcus Reference Laboratory, Department of Microbiology, Stobhill Hospital, Balornock Road, Glasgow G21 3UW, UK 2Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK.
authors.forename: D
authors.initials: D
authors.lastname: Lawrie
authors.affiliation: Scottish Meningococcus and Pneumococcus Reference Laboratory, Department of Microbiology, Stobhill Hospital, Balornock Road, Glasgow G21 3UW, UK 2Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Diggle
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D001769:Blood / Q000382:microbiology; D002939:Ciprofloxacin / Q000494:pharmacology; D004269:DNA, Bacterial / Q000737:chemistry / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D012703:Serotyping; D013183:Sputum / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D010406:Penicillins; D002939:Ciprofloxacin; D004917:Erythromycin