title: Physiologically based pharmacokinetics of bisphenol A.
abstract: A physiologically based pharmacokinetic (PBPK) model consisting of vein, artery, lung, liver, spleen, kidneys, heart, testes, muscle, brain, adipose tissue, stomach, and small intestine was developed to predict the tissue distribution and blood pharmacokinetics of bisphenol A in rats and humans. To demonstrate the validity of the developed PBPK model, bisphenol A was administered to rats by multiple iv injections to steady state. The PBPK model predicted the steady-state levels of bisphenol A in blood and various tissues observed in rats after multiple iv injections. The PBPK model was further applied to predict blood and various tissue levels of bisphenol A in a 70 kg-human after single iv injection (5-mg dose) and multiple oral administrations to steady state (100-mg doses every 24 h). The simulated steady-state human blood levels (0.9-1.6 ng/ml) were comparable to basal blood levels of bisphenol A reported in literature (1.49 ng/ml). Furthermore, pharmacokinectic parameters of CL (116.6 L/h), Vss (141.8 L), and t1/2 (76.8 min) predicted for humans were comparable to those previously predicted by simple allometric scaling. This PBPK model may provide insights into the tissue distribution characteristics as a result of human exposure to bisphenol A.
authors.affiliation: College of Pharmacy, Sungkyunkwan University, Kyonggi-do, Korea.
authors.forename: Beom Soo
authors.initials: BS
authors.lastname: Shin
authors.forename: Chul Hwan
authors.initials: CH
authors.lastname: Kim
authors.forename: Yoon Sik
authors.initials: YS
authors.lastname: Jun
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Kim
authors.forename: Byung Mu
authors.initials: BM
authors.lastname: Lee
authors.forename: Chi Ho
authors.initials: CH
authors.lastname: Yoon
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Park
authors.forename: Kang Choon
authors.initials: KC
authors.lastname: Lee
authors.forename: Soon-Young
authors.initials: SY
authors.lastname: Han
authors.forename: Kui Lea
authors.initials: KL
authors.lastname: Park
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: Sun Dong
authors.initials: SD
authors.lastname: Yoo
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005544:Forecasting; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D023421:Models, Animal; D008954:Models, Biological; D010636:Phenols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds