Endothelial injury markers with high-dose intravenous iron therapy in renal failure.
Endothelial injury is prevalent in patients with chronic renal failure (CRF) and may be exacerbated by commonly used intravenous (IV) iron therapy. The effects of high-dose IV iron sucrose treatment (200 mg daily in 250 mL of 0.9% saline, administered over 1 hour, median treatment duration 5 days) on circulating endothelium and/or tissue injury markers such as hepatocyte growth factor, thrombomodulin, von Willebrand factor, and C-reactive protein levels were studied. The markers were determined in 24 anemic (mean hemoglobin 9.48 g/dL) pre-dialysis (median creatinine clearance 21.5 mL/min) patients with CRF and defined absolute and/or functional iron deficiency. The measurements were performed before iron administration and 24 hours after the last infusion. All the markers remained unchanged following the IV iron therapy (all p < 0.172); no thrombotic or other adverse effects were observed. In conclusion, the above high-dose IV iron sucrose supplementation does not cause evident endothelial or other tissue injury in patients with CRF, and is clinically safe.
Borawski
Jacek
J
Department of Nephrology and Transplantology with Dialysis Unit, Medical University, Bialystok, Poland. jborawski@post.pl
Gozdzikiewicz
Joanna
J
Abramowicz
Pawel
P
Naumnik
Beata
B
Mysliwiec
Michal
M
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000009:adverse effects; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D007501:Iron / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications / Q000188:drug therapy*; D018180:Thrombomodulin / Q000097:blood; D013927:Thrombosis / Q000139:chemically induced; D014841:von Willebrand Factor / Q000032:analysis
D015415:Biomarkers; D005290:Ferric Compounds; D018180:Thrombomodulin; D014841:von Willebrand Factor; D017228:Hepatocyte Growth Factor; D007501:Iron; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid