title: BINOL catalyzed enantioselective addition of titanium phenylacetylide to aromatic ketones.
abstract: An enantioselective addition of titanium phenylacetylide to ketones, promoted by BINOL, is described; this new enantioselective protocol gives high enantiomeric excess (up to 90% ee) with aromatic ketones using a simple procedure without pyrophoric or expensive reagents.
authors.affiliation: Dipartimento di Chimica G. Ciamician, Via Selmi 2, 40126, Bologna, Italy. piergiorgio.cozzi@unibo.it
authors.forename: Pier Giorgio
authors.initials: PG
authors.lastname: Cozzi
authors.forename: Silvia
authors.initials: S
authors.lastname: Alesi
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000480:Alkynes; C406944:BINOL, naphthol; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D009284:Naphthols; D009942:Organometallic Compounds; D014025:Titanium