[E-cadherin gene mutation in recurrent and metastatic carcinoma of larynx].
OBJECTIVE
To evaluate the role of E-cadherin gene in the process of recurrent and metastasis of laryngeal cancer and to investigate the metastatic mechanism of laryngeal cancer.


METHODS
Exploration of exon 5 and exon 7 of the E-cadherin gene by polymerase chain reaction (PCR), SSCP in the laryngeal cancer.


RESULTS
In normal laryngeal tissues, there was no E-cadherin gene mutation. E-cadherin gene mutation occured only in the primary carcinoma with cervical metastasis and recurrent laryngeal carcinoma. The mutation rate were 67.71% and 28.57% respectively. E-cadherin gene mutation occured more frequently in advanced carcinomas than that in early ones.


CONCLUSIONS
E-cadherin gene mutation with its functional suppression was one of the molecular mechanisms of the laryngeal metastasis. It is suggested that E-cadherin may be a valuable prognostic marker for the carcinoma of larynx.
Li
Lan
L
Department of Otolaryngology, Shenzhen Children's Hospital, Shenzhen 518026.
Guo
Xiaofeng
X
Du
Baodong
B
D015820:Cadherins / Q000235:genetics*; D005091:Exons; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000235:genetics*; D009154:Mutation; D009333:Neck; D009364:Neoplasm Recurrence, Local; D011379:Prognosis
D015820:Cadherins