title: Testicular microlithiasis: an unreported feature of McCune-Albright syndrome in males.
abstract: OBJECTIVE
  To ascertain the incidence of testicular microlithiasis (TM) in boys with McCune-Albright syndrome (MAS).
  
  
  METHODS
  Study population consisted of 8 boys with MAS whose medical records were reviewed with emphasis on their past genitourinary histories. All of the boys underwent a clinical and ultrasonographic (US) scanning of the scrotal and inguinal regions. US results in boys with MAS were compared with those obtained in two control populations consisting of 20 healthy subjects and 12 boys with idiopathic and untreated central precocious puberty (CPP).
  
  
  RESULTS
  Clinical examination revealed urological abnormalities in no patients, whereas US showed a typical picture of TM in 5 of 8 boys. TM was observed in none of the subjects belonging to control populations (v=15.2 and 11.3, respectively; P <.001).
  
  
  CONCLUSIONS
  In a series of 8 boys with MAS we demonstrated a high prevalence (62%) of TM that was associated with neither malignant nor nonmalignant conditions. This finding is unlikely to be only occasional, considering the very low prevalence of TM reported until now in healthy children and young adults and in our results in control populations. TM may be another marker for MAS.
authors.affiliation: Department of Pediatrics, Universities of Messina, Pisa, and Milan, Reginal Margherita Hospital of Turin, Italy. wasniewska@yahoo.it
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wasniewska
authors.forename: Filippo
authors.initials: F
authors.lastname: De Luca
authors.forename: Silvano
authors.initials: S
authors.lastname: Bertelloni
authors.forename: Patrizia
authors.initials: P
authors.lastname: Matarazzo
authors.forename: Giovanna
authors.initials: G
authors.lastname: Weber
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Crisafulli
authors.forename: Mariella
authors.initials: M
authors.lastname: Valenzise
authors.forename: Roberto
authors.initials: R
authors.lastname: Lala
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D020347:Lithiasis / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D011629:Puberty, Precocious / Q000000981:diagnostic imaging / Q000209:etiology; D013733:Testicular Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D013737:Testis / Q000000981:diagnostic imaging; D014463:Ultrasonography