Evaluation of myocardial viability following acute myocardial infarction using 201Tl SPECT after thallium-glucose-insulin infusion--comparison with 18F-FDG positron emission tomography.
OBJECTIVE
The aim of this study was to evaluate myocardial viability in patients after acute myocardial infarction (AMI). We compared 201Tl SPECT after 201Tl with GIK (10% glucose 250 ml, insulin 5 U and KCl 10 mEq) infusion (GIK-201Tl) with resting 201Tl and 99mTc-pyrophosphate (PYP) dual SPECT, positron emission computed tomography (PET) using 18F-fluorodeoxyglucose (18F-FDG) in 21 patients with their first AMI, who all underwent successful reperfusion. GIK-201Tl SPECT, 201Tl and 99mTc-PYP dual SPECT were done within 10 days after admission and 18F-FDG-PET was performed at 3 weeks. GIK-201Tl SPECT was obtained after 30 min of GIK-201Tl infusion. 18F-FDG (370 MBq) was injected intravenously after oral glucose (1 g/ kg) loading, and then PET was obtained. PET and SPECT images were divided into 20 segments. Regional tracer uptake was scored using a 4-point scoring system (3 = normal to 0 = defect), and summed to a regional uptake score (RUS). Regional area means the infarcted area in which 99mTc-PYP accumulated. The number of decreased uptake segments (ES) was then determined. The infarcted area was defined as the area of 99mTc-PYP uptake.


RESULTS
The ESs for the GIK-201Tl and 18F-FDG-PET images were significantly lower than the number of 99mTc-PYP uptake segments. The RUS for GIK-201Tl was higher than that for resting-201Tl imaging and similar to those for 18F-FDG-PET.


CONCLUSIONS
In the detection of myocardial viability following AMI, GIK-201Tl imaging is useful with findings similar to those of 18F-FDG-PET.
Toyama
Takuji
T
Gunma Prefectural Cardiovascular Center, Japan. toyama.t@cvc.pref.gunma.jp
Hoshizaki
Hiroshi
H
Seki
Ryotaro
R
Isobe
Naoki
N
Oshima
Shigeru
S
Taniguchi
Koichi
K
Higuchi
Kyosuke
K
Seki
Hidenori
H
Hatori
Takashi
T
Kurabayashi
Masahiko
M
Endo
Keigo
K
D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose; D006801:Humans; D007328:Insulin; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000601:surgery; D049268:Positron-Emission Tomography / Q000379:methods; D011188:Potassium; D011379:Prognosis; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D014022:Tissue Survival; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome
D007328:Insulin; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; C030396:glucose-insulin-potassium cardioplegic solution; D019788:Fluorodeoxyglucose F18; D005947:Glucose; D011188:Potassium