title: [Preventive efficacy of tianeptine in recurrent depression with frequent exacerbations].
abstract: The results of the studies of 4 Russian research centers are summarized. Tianeptine (coaxil) was used in the treatment of 55 patients with ICD-10 diagnosis of recurrent depressive disorder (F32.1), 50 patients have completely finished the treatment. Tianeptine was assigned in dosage of 12.5 mg 3 times daily (patients over 65 years old received 25.0 mg daily) during 12 months. The drug was shown to have a high preventive efficacy for the disorder. Sixty-one percent of patients were full-responders. Taken together with partial responders (13%), an improvement was observed in 74% patients. The drug demonstrated a well tolerability with a rare and mild expression of side-effects.
authors.forename: S N
authors.initials: SN
authors.lastname: Mosolov
authors.forename: O P
authors.initials: OP
authors.lastname: Vertogradova
authors.forename: G P
authors.initials: GP
authors.lastname: Panteleeva
authors.forename: M A
authors.initials: MA
authors.lastname: Morozova
authors.forename: E G
authors.initials: EG
authors.lastname: Kostiukova
authors.forename: A V
authors.initials: AV
authors.lastname: Gorodnichev
authors.forename: L I
authors.initials: LI
authors.lastname: Abramova
authors.forename: G S
authors.initials: GS
authors.lastname: Bannikov
authors.forename: I V
authors.initials: IV
authors.lastname: Timofeef
authors.forename: I V
authors.initials: IV
authors.lastname: Oleĭchik
authors.forename: V V
authors.initials: VV
authors.lastname: Artiukh
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000517:prevention & control* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D010507:Periodicity; D012008:Recurrence; D013841:Thiazepines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine