title: Factors associated with mitral annular systolic and diastolic velocities in healthy adults.
abstract: BACKGROUND
  Measurements of systolic mitral annular velocity (S'), early diastolic mitral annular velocity (E'), and late diastolic mitral annular velocity (A') are used to assess left ventricular (LV) function.
  
  
  OBJECTIVE
  We sought to investigate the relationship between septal and lateral annular velocities and determine whether these velocities are related to body size (including body mass index [BMI]), heart rate (HR), blood pressure, or LV mass.
  
  
  METHODS
  A total of 60 healthy participants who were normotensive, between age 20 and 52 years, underwent standard echocardiography and measurement of septal and lateral S', E', and A'.
  
  
  RESULTS
  The lateral velocity exceeded the septal velocity for S', E', and A'. There was only weak to moderate correlation between the velocities at the two sites (r = 0.43-0.60). Septal S' was positively correlated with height and HR, and lateral S' was correlated with HR. Septal E' was negatively correlated with age, BMI, LV mass, and diastolic blood pressure, but lateral E' was only negatively correlated with age and BMI. Septal A' was positively correlated with age, HR, and BMI, whereas lateral A' was only positively associated with age.
  
  
  CONCLUSIONS
  S', E', and A' are not only of different magnitudes at the septal and lateral sites, but are not closely correlated. There are relationships between annular velocities and body size, HR, blood pressure, and LV mass that differ between the septal and lateral annulus, providing a possible explanation for the lack of close correlation in these velocities and suggesting that these variables may need to be considered when interpreting annular velocities.
authors.affiliation: Centre for Heart and Chest Research, Monash University Department of Medicine, Clayton, Victoria, Australia.
authors.forename: Roger E
authors.initials: RE
authors.lastname: Peverill
authors.forename: John S
authors.initials: JS
authors.lastname: Gelman
authors.forename: Philip M
authors.initials: PM
authors.lastname: Mottram
authors.forename: Stuart
authors.initials: S
authors.lastname: Moir
authors.forename: Clive
authors.initials: C
authors.lastname: Jankelowitz
authors.forename: Janette L
authors.initials: JL
authors.lastname: Bain
authors.forename: Lesley
authors.initials: L
authors.lastname: Donelan
mesh_terms: D000328:Adult; D003971:Diastole / Q000502:physiology*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology*