Breast cancer risk associated with estrogen receptor expression in epithelial hyperplasia lacking atypia and adjacent lobular units.
Estrogen is associated with many epidemiologic risk factors for invasive breast cancer. Cells that express estrogen receptors (ERs) in epithelial hyperplasia lacking atypia (EHLA) may influence breast cancer progression. We conducted a nested case-control study of 268 women with biopsy-confirmed EHLA to determine whether immunohistochemical expression of ERalpha in EHLA affects subsequent breast cancer risk. Study subjects could not have a prior or current history of breast cancer or atypical hyperplasia. Immunohistochemical stains in individual lesions and adjacent normal lobules were considered positive if >or= 10% of epithelial cells stained for ERalpha. The risk of invasive breast cancer in EHLA patients with ERalpha-positive normal lobules was twice that of other EHLA patients (95% CI = 1.0-3.8). This risk was not affected by the ERalpha status of EHLA lesions. ERalpha expression in adjacent normal lobules increases the moderate breast cancer risk previously associated with EHLA.
Gobbi
Helenice
H
Department of Anatomic Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Dupont
William D
WD
Parl
Fritz F
FF
Schuyler
Peggy A
PA
Plummer
W Dale
WD
Olson
Sandra J
SJ
Page
David L
DL
D001943:Breast Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D018275:Carcinoma, Lobular / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology*; D007124:Immunoenzyme Techniques; D011230:Precancerous Conditions / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors
D047628:Estrogen Receptor alpha