title: Does technetium-99m diethylenetriaminepentaacetate clearance predict the clinical course of idiopathic pulmonary fibrosis?
abstract: Clearance of inhaled technetium-99m diethylenetriaminepentaacetate (99mTc-DTPA) is a potential indicator of disease activity and progression in idiopathic pulmonary fibrosis (IPF). The objective of the present study was to evaluate the prognostic value of 99mTc-DTPA scans in IPF. A total of 22 patients (18 males), aged 33 to 80 years with IPF were followed for six to 20 months (mean 13 months). At diagnosis, high resolution computed tomography (HRCT) scans showed a honeycomb pattern with bibasilar reticular opacities in all cases. At T0 (diagnosis) and T1 (follow-up), each patient had pulmonary function tests (forced vital capacity, diffusing capacity of the lung for carbon monoxide and partial arterial O2 pressure), extension of fibrosis evaluated by HRCT visual score and 99mTc-DTPA lung clearance. Results at T0 and T1 were compared, taking into account the whole population and patients with relatively fast and slow 99mTc-DTPA wash-out. 99mTc-DTPA clearance did not show any significant correlation with functional tests or HRCT score. These findings indicate that clearance of inhaled 99mTc-DTPA is not of value in following the progress of IPF.
authors.affiliation: Unita operativa Fisiopatologia Respiratoria, Policlinico Sant' Orsola Malpighi, Bologna. mmura@uhnres.utoronto.ca
authors.forename: Marco
authors.initials: M
authors.lastname: Mura
authors.forename: Gelorma
authors.initials: G
authors.lastname: Belmonte
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
authors.forename: Angela Maria Grazia
authors.initials: AM
authors.lastname: Pacilli
authors.forename: Luca
authors.initials: L
authors.lastname: Fasano
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zompatori
authors.forename: Mario
authors.initials: M
authors.lastname: Schiavina
authors.forename: Mario
authors.initials: M
authors.lastname: Fabbri
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003948:Diagnostic Techniques, Respiratory System; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012720:Severity of Illness Index; D016284:Technetium Tc 99m Pentetate / Q000008:administration & dosage
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate