[Studies on the influencing factors on the drug release from sodium alginate matrices].
OBJECTIVE
To investigate the in vitro influencing factors on drug release from matrices with sodium alginate as the hydrophilic polymer.


METHODS
Sodium alginate hydrophilic matrix tablets were prepared by direct compression method with theopylline as a model drug. The in vitro influencing factors on drug release behavior from matrices were studied by investigating the swelling, water uptake and erosion characteristics of pure sodium alginate matrices.


RESULTS
The results showed that drug release rate and drug release mechanism were both related to the viscosity of sodium alginate used in matrices, pH values and ionic strength of dissolution media and rotation speeds.


CONCLUSIONS
Sodium alginate can be tailor-made to suit the demands of applicants in sustained delivery systems as a good candidate of hydrophilic polymer.
Nie
Shu-Fang
SF
School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang 110016, China. niesf77@163.com
Wu
Xue-Ming
XM
Liu
Hong-Fei
HF
Jiang
Hua-Wei
HW
Pan
Wei-San
WS
D000464:Alginates / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D020723:Glucuronic Acid / Q000008:administration & dosage* / Q000737:chemistry; D006603:Hexuronic Acids / Q000008:administration & dosage* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D012995:Solubility; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry; D014783:Viscosity
D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D013607:Tablets; D020723:Glucuronic Acid; D013806:Theophylline