[Expression and significance of serum sICAM-1 and sCD4 & sCD8 in patients with nasopharyngeal carcinoma].
OBJECTIVE
To study the expression of serum sICAM-1 and sCD4 & sCD8 antigens in patients with nasopharyngeal carcinoma and clinical significances.


METHODS
The serum levels of sICAM-1 and sCD4 & sCD8 antigens were determined in 54 patients with nasopharyngeal carcinoma (NPC group) and 32 healthy adults (normal group) by ELISA.


RESULTS
Expressions of serum sICAM-1 and sCD4 & sCD8 antigens in NPC group were significantly higher than that in normal group (P < 0.01, respectively). The levels of serum sICAM-1 in patients with III-IV stages were higher than those with I-II stages (P < 0.05), and those in patients with no lymph node metastasis lower than in lymph node metastasis (P < 0.01); but the serum levels of sCD4 and sCD8 antigens were not related to UICC-TNM stages in nasopharyngeal carcinoma (P > 0.05). The levels of serum sICAM-1 and sCD4 & sCD8 antigens decreased significantly in disappearance of tumor and metastatic lymph node after radiotherapy (P < 0.01).


CONCLUSIONS
sICAM-1 might be involved in the cellular immunopathogenesis of nasopharyngeal carcinoma, and the measurement of the serum sICAM-1 and sCD4 and sCD8 antigens may reflect ability of neoplasm cell in freedom from host immunological surveillance. Dynamic measurement of serum sICAM-1 and sCD4 and sCD8 antigens may be a useful objective index to evaluate prognosis and curative effects of nasopharyngeal carcinoma.
Wang
Liancong
L
Department of Otolaryngology, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009.
Shu
Meibao
M
Wei
Qichun
Q
Xiang
Jianjie
J
D000328:Adult; D000368:Aged; D015704:CD4 Antigens / Q000097:blood*; D016827:CD8 Antigens / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000473:pathology; D011379:Prognosis
D015704:CD4 Antigens; D016827:CD8 Antigens; D018799:Intercellular Adhesion Molecule-1