Asymmetric hydrogenation of ketones using a ruthenium(II) catalyst containing BINOL-derived monodonor phosphorus-donor ligands.
[structure: see text] A series of ruthenium(II) complexes containing BINOL-based monodonor phosphorus ligands have been prepared and applied to the asymmetric catalysis of the hydrogenation of aryl/alkyl ketones. The best ligands for this application are those which contain an aromatic groups with either a methoxide or bromide on the ortho position. Using these ligands, alcohols with ee's of up to 99% are formed.
Xu
Yingjian
Y
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Alcock
Nat W
NW
Clarkson
Guy J
GJ
Docherty
Gordon
G
Woodward
Gary
G
Wills
Martin
M