The many faces of filamin: a versatile molecular scaffold for cell motility and signalling.
Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.
Feng
Yuanyi
Y
Department of Neurology, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, New Research Building Rm 266, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Walsh
Christopher A
CA
D001921:Brain / Q000002:abnormalities; D002465:Cell Movement; D003285:Contractile Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005260:Female; D064448:Filamins; D006801:Humans; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D020125:Mutation, Missense; D015398:Signal Transduction
D003285:Contractile Proteins; D064448:Filamins; D008840:Microfilament Proteins