Post-translational modification of p53 in tumorigenesis.
Interest in the tumour suppressor p53 has generated much information regarding the complexity of its function and regulation in carcinogenesis. However, gaps still exist in our knowledge regarding the role of p53 post-translational modifications in carcinogenesis and cancer prevention. A thorough understanding of p53 will be extremely useful in the development of new strategies for treating and preventing cancer, including restoration of p53 function and selective killing of tumours with mutant TP53.
Bode
Ann M
AM
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA.
Dong
Zigang
Z
D000107:Acetylation; D000123:Acetyltransferases / Q000502:physiology; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004247:DNA / Q000378:metabolism; D016158:Genes, p53; D006801:Humans; D009154:Mutation; D009363:Neoplasm Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010766:Phosphorylation; D000071156:Promyelocytic Leukemia Protein; D011485:Protein Binding; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D013312:Stress, Physiological / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism* / Q000502:physiology / Q000528:radiation effects; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin / Q000378:metabolism; D014466:Ultraviolet Rays
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; C070576:PML protein, human; D004247:DNA; D000123:Acetyltransferases; D011494:Protein Kinases