A case of refractory bullous pemphigoid with plasmapheresis-associated thrombopenia: efficacy of pulsed intravenous cyclophosphamide therapy.
We present a 69-year-old woman with refractory bullous pemphigoid successfully treated with pulsed intravenous cyclophosphamide therapy. Because various other early treatments including 4,4'-diaminodiphenylsulphone (DDS), minocycline/nicotinamide, cyclosporin, azathioprine, high-dose oral prednisolone, and methylprednisolone pulse therapy were either ineffective or intolerable, she was treated with double filtration plasmapheresis, but she responded poorly with the rare complication of severe transient thrombopenia. Finally, she gradually recovered with pulsed intravenous cyclophosphamide therapy.
Ogawa
Yasushi
Y
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Adachi
Ayumi
A
Okamoto
Miyako
M
Hashimoto
Takashi
T
Tomita
Yasushi
Y
D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007262:Infusions, Intravenous; D010391:Pemphigoid, Bullous / Q000628:therapy*; D010956:Plasmapheresis / Q000009:adverse effects*; D020551:Pulse Therapy, Drug; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide