title: Postmastectomy electron-beam chest-wall irradiation in women with breast cancer.
abstract: OBJECTIVE
  This retrospective study evaluates the results of postmastectomy electron-beam chest-wall irradiation in patients with breast cancer.
  
  
  METHODS
  From 1980 to 1994, 144 women with localized breast cancer received postmastectomy radiotherapy. The chest wall was irradiated by electron beam, 6 to 12 MeV energy, depending on wall thickness, 2.0 Gy daily, 5 times/week for total dose of 50 Gy. Forty-one patients received 16-Gy boosts to the mastectomy scar. In addition, the supraclavicular and axilla areas were irradiated by anterior field with 6-MV photon beam.
  
  
  RESULTS
  Median follow-up was 84 months. Fifteen patients (10%) had local-regional recurrence (LRR) and 57 patients (40%) had systemic relapse (SR). Median time from mastectomy to LRR was 20 months and median time to SR was 33 months. Axillary lymph nodes status influenced both LRR and SR. LRR rate was 0% in N0 and 12% in N1 disease; SR rate was 14% in N0 and 45% in N1 disease. Disease-free and overall survival was 58% and 67% in 10 years and 50% and 55% in 20 years, respectively. No cardiac toxicity was related to left chest-wall irradiation.
  
  
  CONCLUSIONS
  Postmastectomy electron-beam chest-wall irradiation is as effective as photon-beam irradiation in breast cancer.
authors.affiliation: Department of Oncology, Rambam Medical Center, Haifa, Israel. e_gez@rambam.health.gov.il
authors.forename: Eliahu
authors.initials: E
authors.lastname: Gez
authors.forename: Nurit
authors.initials: N
authors.lastname: Assaf
authors.forename: Nurit
authors.initials: N
authors.lastname: Ashaf
authors.forename: Rachel
authors.initials: R
authors.lastname: Bar-Deroma
authors.forename: Edward
authors.initials: E
authors.lastname: Rosenblatt
authors.forename: Abraham
authors.initials: A
authors.lastname: Kuten
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D004583:Electrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015182:Lymphatic Irradiation; D008408:Mastectomy; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology; D011879:Radiotherapy Dosage; D012008:Recurrence; D012189:Retrospective Studies; D012867:Skin / Q000528:radiation effects; D015996:Survival Rate; D035441:Thoracic Wall