title: Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats.
abstract: The purpose of this study was to examine the effectiveness of collagen peptide intake on bone metabolism in growing (G) and calcium-deficient mature (M) rats. As for the dosages used, they were amounts equal to the recommended supplements for humans (0.166 g/kg body weight (BW) per day: Coll-1G and Coll-1M groups), 10-fold higher (1.66 g/kg BW per day: Coll-10G and Coll-10M groups), and 100-fold higher (16.6 g/kg BW per day: Coll-100G group). In growing male rats, bone mineral density (BMD) of the femur in the Coll-100G group was significantly higher than that in the other groups after the 4-week experimental period. On the other hand, kidneys in the rats from the Coll-100G group exhibited hypertrophy. To examine the effects of collagen peptide on bone metabolism in a calcium-deficient status, mature female rats were fed a 0.01% Ca diet for 9 weeks and then fed a diet with 0.2% calcium with or without collagen peptide (control, Coll-1M, and Coll-10M groups) or a 0.5% calcium diet (normal Ca) for 8 weeks. BMD of the whole femur in the Coll-10M group was significantly higher than that in the control and Coll-1M groups, and the level was similar to that in the normal Ca group. BMD of the lumbar spine in the Coll-10M group was significantly higher than their baseline value, as well as being significantly higher than that in the control and Coll-1M groups. These results suggest that orally administered collagen peptide may provide beneficial effects on bone metabolism, especially in the calcium-deficient condition, without obvious undesirable effects.
authors.affiliation: Division of Applied Food Research, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Maiko
authors.initials: M
authors.lastname: Fujioka
authors.forename: Kiho
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Gang
authors.initials: G
authors.lastname: Mu
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ishimi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D002136:Calcium, Dietary / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D004341:Drug Evaluation; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000502:physiology*; D008297:Male; D010455:Peptides / Q000008:administration & dosage*; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002136:Calcium, Dietary; D010455:Peptides; D003094:Collagen