title: Invasive fungal rhinosinusitis in immunocompromised patients.
abstract: BACKGROUND
  Invasive fungal rhinosinusitis (IFR) is one of the most important causes of morbidity and mortality in immunocompromised patients, principally those with cellular immunodeficiency, with mortality ranging from 50 to 80%. Prophylaxis and early diagnosis increase the chances of successful treatment.
  
  
  METHODS
  Clinical prospective randomized study.
  
  
  OBJECTIVE
  To present cases of IFR and to compare them with data reported in the literature.
  
  
  METHODS
  Analysis of eleven cases of IFR confirmed by pathologist examination.
  
  
  RESULTS
  Aspergillus was found to be the most prevalent pathogen. Symptoms ranged from high fever in most cases to nasal discharge, ulceration of the nasal mucosa, headache and periorbital edema.
  
  
  CONCLUSIONS
  The combination of amphotericin B and endoscopic surgery, associated or not with Caldwell-Luc surgery, showed good results. The use of liposomal amphotericin B also presented a satisfactory outcome.
authors.affiliation: Department of Otorhinolaryngology, Ophthalmology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brasil. mcecilia@hcrp.fmrp.usp.br
authors.forename: Wilma T
authors.initials: WT
authors.lastname: Anselmo-Lima
authors.forename: Rony P
authors.initials: RP
authors.lastname: Lopes
authors.forename: Fabiana C P
authors.initials: FC
authors.lastname: Valera
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Demarco
mesh_terms: D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy*; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B