Antidepressant--like properties of ACEA (arachidonyl-2-chloroethylamide), the selective agonist of CB1 receptors.
The antidepressant effect of ACEA (arachidonyl-2-chloroethylamide), a selective agonist of CB1 receptors, and its interaction with fluoxetine were studied in mice. ACEA (1.0 and 2.0 mg/kg i.p.) reduced the immobility time in the forced swimming test and attenuated the head - twitch response to L-5-HTP. The concomitant administration of ACEA (1.0 mg/kg i.p.) and fluoxetine (20 mg/kg i.p.) resulted in the strongest shortening of immobility time, significant in comparison with both ACEA and fluoxetine given alone. The obtained results indicate that ACEA may have antidepressant efficacy and shows a synergistic effect when given with fluoxetine in the forced swimming test.
Rutkowska
Maria
M
Department of Pharmacology, Medical University of Wrocław.
Jachimczuk
Oskar
O
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000494:pharmacology*; D007103:Immobilization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists* / Q000502:physiology
D000928:Antidepressive Agents; D001095:Arachidonic Acids; D043884:Receptor, Cannabinoid, CB1; C119325:arachidonyl-2-chloroethylamide