Low nephron number--a new cardiovascular risk factor in children?
There is increasing evidence that primary hypertension, coronary heart disease, and other aspects of the so-called metabolic syndrome that develop in adulthood are primed in fetal life or early postnatally. The identification of this phenomenon, also known as prenatal or fetal programming, and the detailed characterization of the underlying pathomechanisms will greatly influence the understanding of these diseases. The present paper reviews recent experimental and clinical evidence that low nephron number, found in patients with renal dysplasia and low birth weight, is a risk factor for cardiovascular disease in later life. Therefore, it is important to identify children at risk as early as possible in order to treat them early and to prevent the development of end-organ damage. This could be an important goal for pediatrics in the near future.
Amann
Kerstin
K
Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstrasse 8-10, 91054 Erlangen, Germany. kerstin.amann@patho.imed.uni-erlangen.de
Plank
Christian
C
Dötsch
Jörg
J
D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D009399:Nephrons / Q000033:anatomy & histology*; D012307:Risk Factors