P21WAF1/CIP1 protein and tongue cancer prognosis.
The expression of the cell cycle regulatory protein p21waf1/cip1 was analyzed immunohistochemically in tissue from the tumor and adjacent non-tumor epithelia of 54 patients with tongue cancer in order to determine the proportion of tongue carcinomas with altered p21waf1/cip1 expression, establish whether this alteration is an early event in tongue carcinogenesis and to investigate whether p21waf1/cip1 expression has predictive prognostic value in these tumors. The percentage of p21waf1/cip1-positive neoplastic cells was calculated. Adjacent non-tumor epithelium was classified as normal, hyperplastic or dysplastic, and the p21waf1/cip1 expression was only considered normal in suprabasal layers. P21waf1/cip1 expression was negative in 57.4% (31/54) of the tumors and was aberrant in the non-tumor adjacent tissue of all patients studied. Neither the absence nor the degree of p21waf1/cip1 expression influenced the survival of patients in the present series. P21waf1/cip1 system alteration may be an early and frequent event in tongue carcinogenesis.
Gonzalez-Moles
M A
MA
Department of Oral Medicine, School of Dentistry, University of Granada, Spain. magonzal@ugr.es
Ruiz-Avila
I
I
Martinez
J A Fernández
JA
Gil-Montoya
J A
JA
Esteban
F
F
Gonzalez-Moles
S
S
Bravo-Perez
M
M
Bascones
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins