[Comparative genomic hybridization analysis of laryngeal carcinoma].
In order to find out the genes involved in the tumorigenesis of laryngeal carcinoma, we analyzed 18 laryngeal carcinoma with comparative genomic hybridization. Results show that each one has different degree of variances, included gains and losses of partial and whole chromosome. Each case has 12.9 abnormal regions averagely; losses are more than gains, equal to 7.2 and 5.7 per case respectively. Main regions are gains in chromosomes 3q (78%), 5p (61%), 11q (56%), 1q (50%), 8p (44%), 8q (39%) and 15q (39%), and losses of 3p (70%), 5q (78%), 9p (67%), 13q (50%), 1p (44%) and 14q (39%). There are many specific gains and losses in several chromosomes,especially the increase of copy number karyotype in 1p13-21(8/18), 3p21-23 (14/18), 5p21-22 (14/18), 9p12-pter (10/18) and 13q21-31 (8/18), while the decrease in 1q11-21 (11/18), 3q15-21 (12/18), 8p22-24 (6/18), 11q12-13 (8/18), 15q21-23 (7/18), 18p11 (8/18) are the characteristic varieties. These results suggest that there are oncogene, tumor suppressor gene and other associated genes involved in the tumorigenesis.
Shang
Chao
C
Department of Medical Genetics, China Medical University, Shenyang 110001, China.
Fu
Wei-Neng
WN
Xu
Zhen-Ming
ZM
Li
Fu-Cai
FC
Huang
Dai-Fa
DF
Sun
Kai-Lai
KL
D017766:Acid Anhydride Hydrolases / Q000235:genetics; D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D002869:Chromosome Aberrations; D016147:Genes, Tumor Suppressor; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D000070957:MutL Protein Homolog 1; D009363:Neoplasm Proteins / Q000235:genetics; D009687:Nuclear Proteins; D009693:Nucleic Acid Hybridization; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D000070957:MutL Protein Homolog 1; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D000099170:Bis(5'-adenosyl)triphosphatase; C501486:MLH1 protein, human