[Inhibition of adenosine deaminase activity by drugs influencing the cardiovascular system].
Adenosine deaminase (ADA) is an unique enzyme which catalyzes conversion of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine respectively. One of physiological roles of this enzyme is modulation of its substrate--adenosine concentration (both intracellular and extraectocellular). In presented work the influence of acetylsalicylic acid, metoprolol, simvastatin, isosorbide mononitrate and molsidomine on total activity of adenosine deaminase and its isoenzymes--ADA1 and ADA2 in vivo was studied. We have affirmed that simvastatin decreased of tADA activity by 50%, acetylsalicylic acid by 34%, metoprolol by 29.1% and isosorbide mononitrate by 19.3%. Only after molsidomine administration were no significant changes in ADA activity observed. The result showed that the decline of ADA activity was mainly due to marked decrease in ADA2 isoenzyme.
Kopff
Maria
M
Zakład Chemii i Biochemii Klinicznej IBF UM w Lodzi. mkopff@wp.pl
Kowalczyk
Edward
E
Kopff
Anna
A
D000241:Adenosine / Q000378:metabolism*; D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects* / Q000201:enzymology*; D003839:Deoxyadenosines / Q000378:metabolism*; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D008981:Molsidomine / Q000494:pharmacology; D011817:Rabbits; D011897:Random Allocation; D019821:Simvastatin / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects / Q000201:enzymology
D058892:Adenosine Deaminase Inhibitors; D002317:Cardiovascular Agents; D003839:Deoxyadenosines; D005343:Fibrinolytic Agents; D007527:Isoenzymes; D014665:Vasodilator Agents; D019821:Simvastatin; D008981:Molsidomine; D008790:Metoprolol; D007548:Isosorbide Dinitrate; D000241:Adenosine; C030397:isosorbide-5-mononitrate; C058118:2'-deoxyadenosine; D001241:Aspirin