title: Intracerebroventricular injection of neuropeptide EI increases serum LH in male and female rats.
abstract: Melanin concentrating hormone (MCH) precursor-derived neuropeptide EI (NEI) has not yet been extensively studied. The aim of this study was to determine the effect of neuropeptide EI on serum levels of LH in normal male rats and chronically ovariectomized (CHR-OVX) female rats treated with estrogen benzoate (EB) and with a low dose of progesterone. The peptide, administered intracerebroventricularly in male and chronically ovariectomized female rats, increased LH serum levels compared to the controls injected with artificial cerebrospinal fluid. It is important to note that there is some relation between neuropeptide EI-melanin concentrating hormone and alpha-melanocyte stimulating hormone (alpha-MSH) indicating that all three peptides are associated in a complex inter-relationship. Therefore, the question that arises is if neuropeptide EI could also be related with the receptors for melanin concentrating hormone or alpha-melanocyte stimulating hormone.
authors.affiliation: Laboratorio de Ciencias Fisiológicas, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional de Córdoba, Córdoba CP5000, Argentina.
authors.forename: Andrés M
authors.initials: AM
authors.lastname: Attademo
authors.forename: Mariela
authors.initials: M
authors.lastname: Sánchez-Borzone
authors.forename: Mercedes
authors.initials: M
authors.lastname: Lasaga
authors.forename: Maria Ester
authors.initials: ME
authors.lastname: Celis
mesh_terms: D000818:Animals; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D007276:Injections, Intraventricular; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D004967:Estrogens; D009479:Neuropeptides; D009842:Oligopeptides; C522850:neuropeptide EI; D011374:Progesterone; D007986:Luteinizing Hormone