Effects of the Chinese drugs for activating blood circulation on plasma TXB2 and 6-keto-PGF1alpha contents in rabbits with glucocorticoid-induced femoral head necrosis.
In the femoral head necrosis model rabbit induced by endotoxin combined with methylprenisolone, the dynamical changes of plasma TXB2 and 6-keto-PGF1alpha contents were observed. As a result, microscopic examination showed that in the model group, bone trabeculae became fine, empty bone lacunae increased, and osteoblasts in number decreased; the ratio of TXB2 and 6-keto-PGF1alpha was out of balance, and these changes worsened gradually with the lapse of time; Compound Sheng Mai Cheng Gu Capsules could reverse femoral head necrosis, protect the vascular endothelial cells, recover the balance of TXB2 and 6-keto-PGF1alpha. It is concluded that the hormone-induced femoral head necrosis is closely related with blood stasis, and that the Chinese drugs for activating blood circulation and removing blood stasis can prevent the femoral head from development of necrosis.
He
Wei
W
The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, Guangdong Province.
Xu
Chuanyi
C
Fan
Yueguang
Y
Fang
Bin
B
Li
Xiong
X
Wang
Haibin
H
Liu
Shaojun
S
Yuan
Hao
H
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004731:Endotoxins; D005260:Female; D005271:Femur Head Necrosis / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008516:Medicine, Chinese Traditional; D008775:Methylprednisolone; D010006:Osteoblasts / Q000473:pathology; D011817:Rabbits; D013929:Thromboxane B2 / Q000097:blood*
D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D008775:Methylprednisolone