title: [A case of heparin-induced thrombocytopenia that worsened preexisting cerebral infarction].
abstract: A 75-year-old man was admitted to our hospital with dysesthesia of the right lip, dysphagia and gait disturbance. He presented with right Wallenberg syndrome and brain MR image showed a fresh infarction in the right lateral medulla. Therapy with heparin and ozagrel sodium was started. For a time his symptom improved a little, but after 8 days he developed re-infarction, thrombocytopenia and DIC, while being treated with heparin for cerebral infarction. Heparin was discontinued, and these symptoms improved quickly. The clinical course and the positive anti-platelet factor 4-heparin complex antibody suggested that these symptoms were caused by heparin-induced thrombocytopenia (HIT). HIT should be included as a differential diagnosis for progression of ischemic stroke under heparin therapy.
authors.affiliation: Department of Neurology, The Jikei University Kashiwa Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yaguchi
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Mitsumura
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Ozawa
authors.forename: Hironori
authors.initials: H
authors.lastname: Sato
authors.forename: Kiyoharu
authors.initials: K
authors.lastname: Inoue
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D002544:Cerebral Infarction / Q000503:physiopathology*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D006493:Heparin