Feeding effects on growth during infancy.
OBJECTIVE
To examine the effects of formula, other milks, other liquids, cereals, and other solid foods on growth during infancy.


METHODS
Observational cohort study nested within a large (n=17,046), cluster-randomized trial. We compared growth [weight-for-age, length-for-age, and weight-for-length z scores (WAZ, LAZ, WLZ) and head circumference (HC)] during the intervals 1 to 3, 3 to 6, 6 to 9, and 9 to 12 months, using hierarchical multivariate regression to control for size at the beginning of each interval, maternal education, geographic region, and urban versus rural location.


RESULTS
Mixed BF and formula/other milk were associated with significantly higher (versus breast milk only) LAZ at 1 to 3 months (+0.038 and +0.047, respectively). In the 3- to 6-month interval, mixed BF and formula/other milk led to significantly higher WAZ (+0.125 and +0.139) and LAZ (+0.081 and +0.075), whereas cereal intake was associated with large and highly significant reductions in both measures (-0.293 and -0.240) and in HC (-0.291 cm). Mixed BF and formula/other milk continued to have positive albeit smaller associations with WAZ and LAZ in the 6- to 9-month and 9- to 12-month intervals.


CONCLUSIONS
Our results confirm the growth-accelerating effects of formula and other milks (versus breast milk) on weight and length gain throughout infancy, with a dose-response gradient and largest associations observed at 3 to 6 months.
Kramer
Michael S
MS
Department of Pediatrics, McGill University, Faculty of Medicine, Montreal, Quebec, Canada. michael.kramer@mcgill.ca
Guo
Tong
T
Platt
Robert W
RW
Vanilovich
Irina
I
Sevkovskaya
Zinaida
Z
Dzikovich
Irina
I
Michaelsen
Kim F
KF
Dewey
Kathryn
K
D001827:Body Height; D001835:Body Weight; D001942:Breast Feeding; D002508:Cephalometry; D015331:Cohort Studies; D002523:Edible Grain; D005638:Fruit; D006801:Humans; D041943:Infant Formula / Q000008:administration & dosage*; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn / Q000254:growth & development*; D008895:Milk, Human; D012016:Reference Values; D014867:Water / Q000008:administration & dosage
D014867:Water