[The role of platelet-derived growth factor A (PDGF-A) in hypertension and renal diseases. Part 2: a role of PDGF-A in kidney diseases].
Many studies have suggested deleterious effects of platelet-derived growth factor (PDGF) released by intrinsic renal cells during glomerulonephritis (GN). Increase in PDGF B chain expression has particularly been noted in glomeruli of patients with GN. Less known is the role of PDGF A chain both in the normal kidney and renal diseases. Several lines of evidence have indicated the involvement of PDGF-A in renal graft rejection. Furthermore, an increased expression of PDGF-A has also been observed in the course of human diabetic nephropathy. Still, the role of PDGF-A in the development and progression of GN remains unclear.
Miller-Kasprzak
Ewa
E
Pracownia Nefrologii Molekularnej, Katedra i Klinika Nefrologii, Transplantologii i Chorób Wewnqtrznych AM w Poznaniu.
Niemir
Zofia I
ZI
Czekalski
Stanisław
S
D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000378:metabolism; D005921:Glomerulonephritis / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000235:genetics* / Q000378:metabolism*
D010982:Platelet-Derived Growth Factor; C075278:platelet-derived growth factor A