title: Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review.
abstract: OBJECTIVE
  The aim of this systematic review was to summarize and evaluate the evidence available for oral supplementation with coenzyme Q10 (CoQ10) to improve the tolerability of cancer treatments.
  
  
  METHODS
  Searches for all published and unpublished controlled trials were carried out on seven databases. Manufacturers of CoQ10 were identified and contacted. Controlled clinical trials of monopreparations of CoQ10 administered orally to cancer patients were included. No language restrictions were imposed. Data were extracted independently by two authors according to predefined criteria.
  
  
  RESULTS
  Six studies were included in the review, including three randomized clinical trials and three nonrandomized clinical trials. Patients in five of six studies received anthracyclines. The results suggested that CoQ10 provides some protection against cardiotoxicity or liver toxicity during cancer treatment. However, because of inadequate reporting and analysis, as well as questionable validity of outcome measures, the results are not conclusive.
  
  
  CONCLUSIONS
  Suggestions that CoQ10 might reduce the toxicity of cancer treatments have not been tested by rigorous trials. Further investigations are necessary to determine whether CoQ10 can improve the tolerability of cancer treatments.
authors.affiliation: School of Nursing and Midwifery, University of Southampton, Southampton, UK.
authors.forename: Liz
authors.initials: L
authors.lastname: Roffe
authors.forename: Katja
authors.initials: K
authors.lastname: Schmidt
authors.forename: Edzard
authors.initials: E
authors.lastname: Ernst
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D000975:Antioxidants / Q000627:therapeutic use*; D003067:Coenzymes; D018849:Controlled Clinical Trials as Topic; D019610:Cytoprotection / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10