Paraneoplastic limbic encephalitis: ovarian cancer presenting as an amnesic syndrome.
BACKGROUND
Paraneoplastic limbic encephalitis (PLE) is a rare neurologic manifestation of malignancy. Paraneoplastic limbic encephalitis typically presents with short-term memory loss, seizures, or other limbic system abnormalities. The majority of PLE cases are associated with lung and testicular cancer.


METHODS
We present the first case of PLE attributable to an epithelial ovarian cancer. The 58-year-old woman presented with rapidly progressing short-term memory loss and amnesia. The diagnosis of ovarian cancer was suspected on the basis of computed tomography scan findings. The patient showed dramatic clinical improvement within 2 weeks of debulking surgery and after the initiation of plasmapheresis and chemotherapy.


CONCLUSIONS
Paraneoplastic limbic encephalitis is a rare complication of ovarian tumors that is potentially reversible with prompt surgical management of the primary tumor, plasmapheresis, and chemotherapy.
Bloch
Michael H
MH
Department of Neurology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA. michael.bloch@yale.edu
Hwang
Wei Chan
WC
Baehring
Joachim M
JM
Chambers
Setsuko K
SK
D000647:Amnesia / Q000175:diagnosis*; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D018283:Cystadenocarcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007167:Immunotherapy / Q000379:methods; D020363:Limbic Encephalitis / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy / Q000379:methods; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000628:therapy; D010956:Plasmapheresis / Q000379:methods; D018570:Risk Assessment; D016896:Treatment Outcome