title: Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis.
authors.affiliation: Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York, YO10 5YW, UK.
authors.forename: Florence
authors.initials: F
authors.lastname: Vincent
authors.forename: Tracey M
authors.initials: TM
authors.lastname: Gloster
authors.forename: James
authors.initials: J
authors.lastname: Macdonald
authors.forename: Carl
authors.initials: C
authors.lastname: Morland
authors.forename: Robert V
authors.initials: RV
authors.lastname: Stick
authors.forename: Fernando M V
authors.initials: FM
authors.lastname: Dias
authors.forename: José A M
authors.initials: JA
authors.lastname: Prates
authors.forename: Carlos M G A
authors.initials: CM
authors.lastname: Fontes
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Gilbert
authors.forename: Gideon J
authors.initials: GJ
authors.lastname: Davies
mesh_terms: D044602:Cellulases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006868:Hydrolysis; D050112:Imino Pyranoses; D007700:Kinetics; D007769:Lactams / Q000494:pharmacology; D008968:Molecular Conformation; D010880:Piperidines / Q000494:pharmacology*; D011714:Pyrans / Q000737:chemistry*; D044902:beta-Mannosidase / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D050112:Imino Pyranoses; D007769:Lactams; D010880:Piperidines; D011714:Pyrans; C098432:isofagomine; D044602:Cellulases; D044902:beta-Mannosidase