[Dynamical examination of auditory event-related potentials P300 and sympathetic skin response in people with insomia of Sweet Dream Capsule therapy].
OBJECTIVE
To observe the change of auditory event-related potentials (P300) and sympathetic skin response (SSR) in people with insomia of Sweet Dream Capsule therapy.


METHODS
30 patients meeting criteria for primary insomnia and 30 healthy volunteers with age matching controls were selected for the study. P300 and SSR were measured before treatment of Sweet Dream Capsule and at week 4 , 8 of the therapeutic course. That the change of P300 and SSR before and after treatment and their relations with PSQI were studied.


RESULTS
Compared with those of normal controls, both P300 latency and SSR latency were prolonged while amplitude was decreased in patients with insomnia (P < 0.01). P300 amplitude was increased significantly at central (Cz) electrode sites only at week 8 when compared with amplitude before treatment (P < 0.05). With improvement of symptom and PSQI scores, latency and amplitude of SSR were improved at week 4 and week 8 (P < 0.05 and P < 0.01) .


CONCLUSIONS
P300 has a some improvement in people with insomia of Sweet Dream Capsule therapy while SSR im proves significantly, and PSQI scores are ameliorated too.
Zheng
Xu-Ning
XN
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. zhengxnl@mail.hz.zj.cn
Zhang
Ling-Ju
LJ
Liang
Hui
H
Chen
Wei
W
Zhu
Xiong-Chao
XC
Yuan
Min
M
Liu
Yang
Y
D000328:Adult; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004558:Electric Stimulation; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D012867:Skin / Q000294:innervation*; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal