title: [Incidence of factor VII and C3 in vascular anastomosis].
abstract: In order to study pathogenesis of vascular prosthesis healing process the following experiment was designed. 16 dogs underwent implantation of unilateral straight aorto-femoral teflon (PTFE, polytetrafluoroethylene) by-pass. After 6 months all dogs were killed, dissected and vascular prostheses with margin of adjacent aorta and femoral artery were collected for further study. Areas of proximal and distal anastomosis were examined immunohistochemically. Presence of coagulation factor VII, and C3 complement factor were studied. The obtained results were analyzed statistically by means of t-Student test. Factor VII as well C3 were found in areas of both proximal and distal anastomosis. Concentration of all two substances in proximal and distal anastomosis was compared. No statistically valid differences in factor VII concentration in proximal and distal anastomosis were found, whereas amounts of C3 factor as well as degree of extracellular matrix infiltration were markedly higher in distal anastomosis.
authors.affiliation: Klinika Chirurgii Naczyniowej, Ogólnej i Transplantacyjnej AM we Wrocławiu.
authors.forename: Jan
authors.initials: J
authors.lastname: Skóra
authors.forename: Dariusz
authors.initials: D
authors.lastname: Janczak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Korta
authors.forename: Artur
authors.initials: A
authors.lastname: Pupka
authors.forename: Artur
authors.initials: A
authors.lastname: Ruciński
authors.forename: Piotr
authors.initials: P
authors.lastname: Szyber
authors.forename: Stanisław
authors.initials: S
authors.lastname: Pawłowski
authors.forename: Artur
authors.initials: A
authors.lastname: Milnerowicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Stepiński
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology* / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D003176:Complement C3 / Q000378:metabolism*; D004285:Dogs; D005167:Factor VII / Q000378:metabolism*; D005263:Femoral Artery / Q000473:pathology* / Q000601:surgery*; D007150:Immunohistochemistry; D011138:Polytetrafluoroethylene
chemical_list: D003176:Complement C3; D005167:Factor VII; D011138:Polytetrafluoroethylene