[Liver regeneration after resection: molecular and cellular mechanism].
It has been well established that the liver can regenerate after resection. Liver regeneration is a fundamental mechanism by which the liver responds to injury. This review article discusses molecular and cellular mechanism of liver regeneration, including growth factors and cytokines in the initiation and regulation of liver regeneration, the importance of the liver extracellular matrix and its dynamic effect on hepatocyte growth, and finally, stem cell biology in liver regeneration.
Wakabayashi
Go
G
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Shimazu
Motohide
M
Ueda
Masakazu
M
Tanabe
Minoru
M
Kawachi
Shigeyuki
S
Kitajima
Masaki
M
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D004247:DNA / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000502:physiology; D022781:Hepatocytes / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D008115:Liver Regeneration / Q000235:genetics* / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D050796:STAT3 Transcription Factor; D013234:Stem Cells / Q000166:cytology; D015534:Trans-Activators / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology; D000097782:NF-kappaB-Inducing Kinase
D004247:DNA; D004268:DNA-Binding Proteins; D017228:Hepatocyte Growth Factor; D015850:Interleukin-6; D017346:Protein Serine-Threonine Kinases; D050796:STAT3 Transcription Factor; D015534:Trans-Activators; D014409:Tumor Necrosis Factor-alpha; D014568:Urokinase-Type Plasminogen Activator; D000097782:NF-kappaB-Inducing Kinase; C494086:STAT3 protein, human