Clinical significance of isolated hippocampal volume asymmetry in childhood epilepsy.
This study defines the clinical characteristics and evolution of 16 epileptic children with hippocampal asymmetry (HA) without sclerosis on MRI. The association of a positive family history of epilepsy (11/16), low incidence of febrile seizures (2/16), and benign prognosis (seizure control in monotherapy in 11/16, mean follow-up = 4.3 years, range 1 to 10) suggest a different clinical presentation than patients with mesial temporal sclerosis. Genetic studies of these mostly French Canadian families should help confirm the existence of a distinct syndrome.
Major
P
P
Department of Pediatrics, Neurology Division, Hôpital Sainte-Justine, 3175 Côte Ste-Catherine, Montréal, Québec, Canada.
Décarie
J-C
JC
Nadeau
A
A
Diadori
P
P
Lortie
A
A
Nguyen
D
D
Cossette
P
P
Carmant
L
L
D000293:Adolescent; D000367:Age Factors; D017668:Age of Onset; D000927:Anticonvulsants / Q000627:therapeutic use; D001284:Atrophy / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D018450:Disease Progression; D004351:Drug Resistance / Q000235:genetics; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D005192:Family Health; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D003294:Seizures, Febrile / Q000453:epidemiology; D014057:Tomography, X-Ray Computed
D000927:Anticonvulsants