Genomic imprinting and assisted reproduction.
Imprinted genes exhibit a parent-of-origin specific pattern of expression. Such genes have been shown to be targets of molecular defects in particular genetic syndromes such as Beckwith-Wiedemann and Angelman syndromes. Recent reports have raised concern about the possibility that assisted reproduction techniques, such as in vitro fertilization or intracytoplasmic sperm injection, might cause genomic imprinting disorders. The number of reported cases of those disorders is still too small to draw firm conclusions and the safety of these widely used assisted reproduction techniques needs to be further evaluated.
Paoloni-Giacobino
Ariane
A
Department of Molecular Genetics and Biochemistry, University of Pittsburgh, W1007 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA. apgiacob@pitt.edu.
Chaillet
J Richard
JR