Effect of peptide Pro-Gly-Pro on stress-induced behavioral changes in rats.
Tripeptide PGP in a dose of 1 mg/kg had a correcting effect on behavioral disorders in rats induced by stress exposure (forced swimming). PGP prevented the increase in anxiety and decrease in orientation and exploratory activity. Our results suggest that the effect of this peptide is realized via central nervous structures involved in organism's response to stress factors.
Kopylova
G N
GN
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
Badmaeva
S E
SE
Levitskaya
N G
NG
Samonina
G E
GE
Umarova
B A
BA
Guseva
A A
AA
D000818:Animals; D021461:Animals, Outbred Strains; D001007:Anxiety / Q000517:prevention & control; D001522:Behavior, Animal / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D009949:Orientation / Q000187:drug effects; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological; D013550:Swimming; D013997:Time Factors
D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D011392:Proline