[Analytical evaluation of 1-(dipropalamino-3-piperidine-propane-1-yl)-3-pentyloxyphenylcarbamate (CK-3635)].
The paper presents the results of analytical and pharmacological evaluation and study of some physicochemical properties of a potential drug marked as CK-3635 with high local anaesthetic activity. The structure of the substance has been confirmed by IR and UV spectroscopy. The melting point, solubility, partition coefficient, capacity factor, surface activity, and dissociation constant were determined. The chromatographic behaviour of the drug on a thin layer was also investigated. For the content determination, spectrophotometry in the ultraviolet region of the spectrum at the wavelenght of the second absorption maximum of the substance, the titration in the two-phases ambient, and high-performance liquid chromatography were used.
Malík
I
I
Katedra farmaceutickej chémie, Farmaceutichej fakulty, Univerzity Komenského, Bratislava. malik@fpharm.uniba.sk
Sedlárová
E
E
Csöllei
J
J
D000779:Anesthetics, Local / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D010880:Piperidines / Q000737:chemistry*
C493888:1-(dipropylamino-3-piperidinepropan-1-yl)-3-pentyloxyphenylcarbamate; D000779:Anesthetics, Local; D002219:Carbamates; D010880:Piperidines