title: CART in feeding and obesity.
abstract: CART (cocaine- and amphetamine-regulated transcript) peptides are neurotransmitters that have received much attention as mediators of feeding behavior and body-weight regulation in mammals. CART peptides and their mRNAs are found in many brain regions and in peripheral tissues that are involved in feeding, and many animal studies implicate CART as an inhibitor of feeding. Animal studies also demonstrate that CART expression is regulated by both leptin and glucocorticoids, two hormones known to be associated with the regulation of body weight. A recent study also links a mutation in the CART gene to obesity in humans. These peptides might become targets for drug development in the area of obesity.
authors.affiliation: Neuroscience Division, Yerkes National Research Center of Emory University, Atlanta, GA 30329, USA. rghunter@emory.edu
authors.forename: Richard G
authors.initials: RG
authors.lastname: Hunter
authors.forename: Kelly
authors.initials: K
authors.lastname: Philpot
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Vicentic
authors.forename: Geraldina
authors.initials: G
authors.lastname: Dominguez
authors.forename: George W
authors.initials: GW
authors.lastname: Hubert
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kuhar
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D009765:Obesity / Q000503:physiopathology*; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
chemical_list: D009419:Nerve Tissue Proteins; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein