Roles and regulation of stat family transcription factors in human breast cancer.
Stats (for signal transducers and activators of transcription) are a family of transcription factors that regulate cell growth and differentiation. Their activity is latent until phosphorylation by receptor-associated kinases. A sizable body of data from cell lines, mouse models, and human tissues now implicates these transcription factors in the oncogenesis of breast cancer. Because Stat activity is modulated by several posttranslational modifications and protein-protein interactions, these transcription factors are capable of integrating inputs from multiple signaling networks. Given this, the future utilization of Stats as prognostic markers and therapeutic targets in human breast cancer appears likely.
Clevenger
Charles V
CV
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 513 SC Labs, 422 Curie Blvd., Philadelphia, PA 19104, USA. clevengc@mail.med.upenn.edu
D020816:Amino Acid Motifs; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D042361:Mammary Glands, Human / Q000502:physiology; D051379:Mice; D008894:Milk Proteins; D008954:Models, Biological; D010766:Phosphorylation; D011379:Prognosis; D050794:STAT1 Transcription Factor; D050796:STAT3 Transcription Factor; D050799:STAT5 Transcription Factor; D013329:Structure-Activity Relationship; D015534:Trans-Activators / Q000502:physiology*; D014443:Tyrosine / Q000378:metabolism
D004268:DNA-Binding Proteins; D008894:Milk Proteins; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D050799:STAT5 Transcription Factor; C494080:Stat1 protein, mouse; C494087:Stat3 protein, mouse; D015534:Trans-Activators; D014443:Tyrosine