Does tibolone affect serum leptin levels and body weight in postmenopausal women?
OBJECTIVE
Leptin has a significant role in body weight regulation and energy balance. We examined the effect of tibolone on the body weight and serum leptin levels in postmenopausal women.


METHODS
Twenty women (aged 43-60 years) participated in this prospective study. All women in this study protocol received 2.5 mg/day of tibolone. Absolute and body mass index (BMI)-corrected serum leptin concentrations and BMI values were measured at baseline, after 3 months, and after 6 months of the tibolone therapy.


RESULTS
Tibolone did not affect absolute and BMI-corrected serum leptin levels, and BMI values during the treatment. A significant linear correlation between BMI values and serum leptin levels was observed (p<0.05, r=0.67).


CONCLUSIONS
Tibolone seems not to affect serum leptin levels, body weight and BMI values of postmenopausal women. There is a significant correlation between serum leptin levels and BMI values.
Gol
Mert
M
Department of Obstetrics and Gynecology, Faculty of Medicine, Dokuz Eylul University, Bornova, Izmir, Turkey. mert.gol@deu.edu.tr
Ozsener
Serdar
S
Sendag
Fatih
F
Uretmen
Sevinç
S
Oztekin
Kemal
K
Tanyalcin
Tijen
T
Bilgin
Onur
O
D000328:Adult; D001835:Body Weight / Q000187:drug effects*; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009652:Norpregnenes / Q000494:pharmacology*; D017698:Postmenopause / Q000187:drug effects*; D011446:Prospective Studies
D020847:Estrogen Receptor Modulators; D020738:Leptin; D009652:Norpregnenes; C027385:tibolone