title: Serum thymidine kinase activity: an alternative to histologic markers of cellular proliferation in canine lymphoma.
abstract: Thymidine kinase (TK) is a cellular enzyme which is involved in a 'salvage pathway' of DNA synthesis. It is activated in the G1/S phase of the cell cycle, and its activity has been shown to correlate with the proliferative activity of tumor cells.... Clinical studies have reported high serum TK concentrations in a variety of neoplasias. The majority of these studies concerned hematological malignancies. TK seems to be a useful marker in non-Hodgkin's lymphoma, where it correlates with clinical staging and provides marked prognostic information on (progression-free) survival.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Madewell
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood*; D049109:Cell Proliferation; D004283:Dog Diseases / Q000201:enzymology* / Q000473:pathology; D004285:Dogs; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D013937:Thymidine Kinase / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D013937:Thymidine Kinase