Cellular mechanisms of T cell mediated drug hypersensitivity.
Noncovalent drug presentation leads to the activation of drug-specific T cells. In some patients with hypersensitivity, such a response occurs within hours even upon the first exposure to the drug. Thus, the reaction to the drug might not be due to a classical, primary response, but rather mediated by existing, preactivated T cells that are cross specific for the drug, and have an additional (peptide) specificity as well.
Gerber
Basil O
BO
Division of Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology, PKT2 D572, Inselspital, CH-3010 Berne, Switzerland.
Pichler
Werner J
WJ
D000818:Animals; D004342:Drug Hypersensitivity / Q000235:genetics / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D006801:Humans; D010455:Peptides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014162:Transfection
D006241:Haptens; D010455:Peptides; D011948:Receptors, Antigen, T-Cell