title: Synthesis of small molecule CDC25 phosphatases inhibitors.
abstract: A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.
authors.affiliation: Ipsen Research Laboratories, Institut Henri Beaufour, 5, Avenue du Canada, F-91966 Les Ulis Cédex, France. m-odile.galcera.contour@ipsen.com
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Contour-Galcéra
authors.forename: Olivier
authors.initials: O
authors.lastname: Lavergne
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Brezak
authors.forename: Bernard
authors.initials: B
authors.lastname: Ducommun
authors.forename: Grégoire
authors.initials: G
authors.lastname: Prévost
mesh_terms: D006801:Humans; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D011480:Protease Inhibitors; D020687:cdc25 Phosphatases