Neuropathology: many paths lead to hereditary spastic paraplegia.
Studies with animal models are providing new insights into the pathology of hereditary spastic paraplegia, particularly how mutations in multiple, converging pathways can lead to this family of neuropathies.
Gould
Robert M
RM
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Brady
Scott T
ST
D006801:Humans; D000251:Adenosine Triphosphatases / Q000378:metabolism; D001369:Axons / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D015419:Spastic Paraplegia, Hereditary / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000074181:Spastin; D013572:Synaptic Vesicles / Q000378:metabolism
D000251:Adenosine Triphosphatases; D009185:Myelin Proteins; C400283:SPAST protein, human; D000074181:Spastin