Gene and stem cell therapy of the hair follicle.
The hair follicle is a highly complex appendage of the skin containing a multiplicity of cell types. The follicle undergoes constant cycling through the life of the organism including growth and resorption with growth dependent on specific stem cells. The targeting of the follicle by genes and stem cells to change its properties, in particular, the nature of the hair shaft is discussed. Hair follicle delivery systems are described such as liposomes and viral vectors for gene therapy. The nature of the hair follicle stem cells is discussed, in particular, its pluripotency.
Hoffman
Robert M
RM
AntiCancer Inc., San Diego, CA, USA.
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D018859:Hair Follicle / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D006801:Humans; D007763:Lac Operon / Q000235:genetics; D008081:Liposomes / Q000737:chemistry; D051379:Mice; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
D008081:Liposomes; D049452:Green Fluorescent Proteins