[A case of pulmonary aspergillosis with bone invasion and destruction in an AIDS patient].
A 59-year-old HIV-infected man who had been treated for pulmonary cryptococcosis in another hospital was suffering from pulmonary tuberculosis. He was admitted to our hospital for treatment of tuberculosis. The chest radiograph on admission showed a large cavity in the left lower lung field. Chest CT showed a mass like a fungus ball in the cavity. Pulmonary aspergillosis was diagnosed from the sputum mycology and serum immunoprecipitins. During the treatment of pulmonary tuberculosis and cryptococcosis, thickening of the wall of the cavity was seen together with adjacent bone destruction. In an autopsy, Aspergillus spp. Were found to have invaded the bone tissue and caused bone destruction. Pulmonary aspergillosis in an AIDS patient is infrequent, and is rare in additional association with bone invasion and destruction.
Hara
Hiromichi
H
Department of Pulmonary Diseases, Tokyo National Hospital.
Nagai
Hideaki
H
Tamura
Atsuhisa
A
Akagawa
Shinobu
S
Kawabe
Yoshiko
Y
Nagayama
Naohiro
N
Machida
Kazuko
K
Kurashima
Atsuyuki
A
Komatsu
Hikotarou
H
Yotsumoto
Hideki
H
Hebisawa
Akira
A
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001228:Aspergillosis / Q000209:etiology*; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D001850:Bone Diseases, Infectious / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D018791:CD4 Lymphocyte Count; D003453:Cryptococcosis / Q000209:etiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D006801:Humans; D008172:Lung Diseases, Fungal / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012272:Ribs / Q000382:microbiology / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000209:etiology