title: [Evolutionary predecessors of oncogenesis and old age involution].
abstract: A hypothesis is stated explaining emergence of mechanisms of oncogenesis and old age involution. According to the hypothesis the destructive and proliverative phenomena, observed in the course of these pathological processes, emerged on the basis of the destructive and proliverative phenomena, assotiated with asexual reproduction in the Precambrian Metazoa. The evolutionary predecessor of the oncogenesis was semelparous asexual reproduction, and the evolutionary predecessor of the old age involution was desintegration of tissues associated with iteroparous asexual reproduction. The oncogenesis and old age involution in different lines of the Metazoa originated independently. Processes of the normal ontogenesis in the contempory primitive Invertebrates are pointed out. These are the evolutionary predecessors of regression of tumors and haemoblastosis. The importance of regressive development is discussed.
authors.forename: A V
authors.initials: AV
authors.lastname: Makrushin
mesh_terms: D000375:Aging; D000818:Animals; D005075:Biological Evolution; D049109:Cell Proliferation; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D012100:Reproduction, Asexual