title: Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.
abstract: Nevirapine is a non-nucleoside reverse transcriptase inhibitor used in the treatment of human immunodeficiency virus (HIV)-infected patients and in post-exposure prophylaxis. However, its use has recently been limited because of adverse cutaneous and hepatic effects. We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.
authors.affiliation: Institute of Allergy, Clinical Immunology and AIDS, Rambam Medical Center, 31096 Haifa, Israel. ed_shahar@rambam.health.gov.il
authors.forename: Eduardo
authors.initials: E
authors.lastname: Shahar
authors.forename: Norberto
authors.initials: N
authors.lastname: Krivoy
authors.forename: Sara
authors.initials: S
authors.lastname: Weltfriend
authors.forename: Shimon
authors.initials: S
authors.lastname: Pollack
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced*; D019829:Nevirapine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D019829:Nevirapine