Ondansetron, given during the acute cocaine withdrawal, attenuates oral cocaine self-administration.
We have previously shown that ondansetron, given 3.5 h after intravenous cocaine self-administration, can attenuate self-administration the following day. Here we tested ondansetron given either before or after a 14-h oral cocaine session in rats. Ondansetron (0.2 mg/kg sc) given 30 min before the cocaine session had no effect. However, when given 3.5 h after, ondansetron attenuated cocaine intake the following day while having no effect on water intake. Taken with our previous data in intravenous cocaine self-administration, we suggest that the acute cocaine withdrawal period may be an important treatment window and that ondansetron may be an effective cocaine abuse therapy.
Davidson
Colin
C
Department of Psychiatry, Box 3870, Duke University Medical Center, Durham, NC 27710, USA. colda@duke.edu
Lazarus
Cindy
C
Lee
Tong H
TH
Ellinwood
Everett H
EH
D000284:Administration, Oral; D000818:Animals; D003042:Cocaine / Q000009:adverse effects*; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D003216:Conditioning, Operant / Q000187:drug effects; D008297:Male; D017294:Ondansetron / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013239:Stereotyped Behavior / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D012702:Serotonin Antagonists; D017294:Ondansetron; D003042:Cocaine