title: tRNA maturation: RNA polymerization without a nucleic acid template.
abstract: The CCA-adding enzyme, which builds and repairs the 3' terminal CCA sequence of tRNA, is the only RNA polymerase that can synthesize a defined nucleotide sequence without using a nucleic acid template. New cocrystal structures tell us how this remarkable enzyme works.
authors.affiliation: Department of Biochemistry, University of Washington, Box 357350, Seattle, Washington 98195-7350, USA. amweiner@u.washington.edu
authors.forename: Alan M
authors.initials: AM
authors.lastname: Weiner
mesh_terms: D019611:Archaeoglobus fulgidus / Q000235:genetics / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites / Q000235:genetics; D008957:Models, Genetic; D012316:RNA Nucleotidyltransferases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics* / Q000378:metabolism
chemical_list: D012343:RNA, Transfer; D012316:RNA Nucleotidyltransferases; C023198:tRNA nucleotidyltransferase