Rapid detection of ITPA 94C>A and IVS2 + 21A>C gene mutations by real-time fluorescence PCR and in vitro demonstration of effect of ITPA IVS2 + 21A>C polymorphism on splicing efficiency.
Heller
Tanja
T
Department of Clinical Chemistry, George-August-University, Robert-Koch-Strasse 40, 37099 Göttingen, Germany.
Oellerich
Michael
M
Armstrong
Victor William
VW
von Ahsen
Nicolas
N
D000970:Antineoplastic Agents / Q000009:adverse effects; D005453:Fluorescence; D005838:Genotype; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D017354:Point Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D011687:Purines / Q000009:adverse effects; D011755:Pyrophosphatases / Q000097:blood / Q000235:genetics*; D012326:RNA Splicing; D018570:Risk Assessment; D000097630:Inosine Triphosphatase
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D011687:Purines; D011755:Pyrophosphatases; D000097630:Inosine Triphosphatase