title: Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
abstract: Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Gao
authors.forename: Shannon J
authors.initials: SJ
authors.lastname: Thomas
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Hecht
authors.forename: John S
authors.initials: JS
authors.lastname: Lazo
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000818:Animals; D019951:DNA Polymerase beta / Q000037:antagonists & inhibitors*; D003857:Deoxyuridine / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008190:Lyases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C493698:17-O-isoprenyldictyoceratin-C; D004791:Enzyme Inhibitors; D011809:Quinones; D012717:Sesquiterpenes; C493697:dictyoceratin-C; C467077:ilimaquinone; D019951:DNA Polymerase beta; D008190:Lyases; D003857:Deoxyuridine