Dendritic cell-based immunotherapy of malignant gliomas.
The failure of conventional treatment modalities for gliomas, in spite of tremendous progress in research in the past two decades, has led to increasing interest in alternative treatment strategies, including immunotherapy. It has become evident that vaccination with dendritic cells (DC), designed to express tumor antigens, is a potent strategy to elicit anti-tumor immune response in both pre-clinical and clinical settings. Various methods have been applied in order to induce DC to express tumor antigens including: pulsing with isolated tumor peptides or whole tumor lysate; fusion with tumor cells; and pulsing with apoptotic tumor cells. Herein, we review the recent progress in DC biology with regard to tumor immunity and discuss current DC-based strategies and future prospects in immunotherapy for malignant gliomas.
Parajuli
Prahlad
P
Department of Neurosurgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA. pparajuli@neurosurgery.wayne.edu
Sloan
Andrew E
AE
D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000276:immunology; D017209:Apoptosis; D001932:Brain Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D002459:Cell Fusion; D002478:Cells, Cultured / Q000276:immunology / Q000637:transplantation; D002986:Clinical Trials as Topic; D004273:DNA, Neoplasm / Q000008:administration & dosage; D003713:Dendritic Cells / Q000276:immunology / Q000637:transplantation*; D005544:Forecasting; D005910:Glioma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D016298:Hematopoietic Cell Growth Factors / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006822:Hybrid Cells / Q000637:transplantation; D016219:Immunotherapy, Adoptive; D012334:RNA, Neoplasm / Q000008:administration & dosage; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D004273:DNA, Neoplasm; D016298:Hematopoietic Cell Growth Factors; D012334:RNA, Neoplasm