A model for the oscillatory motion of single dynein molecules.
Axonemal dynein is the molecular motor responsible for the rhythmic beating of eukaryotic cilia and flagella. An individual axonemal dynein molecule is capable of both unidirectional and oscillatory motion along a microtubule (Nature 393 (1998) 711). We propose a model which links the physical motion of a two-headed dynein molecule to its ATP hydrolysis cycle, and which exhibits both processive and oscillatory behaviors. A mathematical analysis of the model is used to make experimentally testable predictions.
Goedecke
D Michael
DM
Biomathematics Graduate Program, North Carolina State University, Raleigh, NC 27695-8203, USA.
Elston
Timothy C
TC
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D004398:Dyneins / Q000502:physiology*; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology*; D013269:Stochastic Processes
D020409:Molecular Motor Proteins; D004398:Dyneins