title: Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer.
abstract: Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients. In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RT-PCR. Two transcripts, BCL2L12 and BCL2L12-A, were overexpressed in the cancer tissues as compared to their paired normal mucosa. An association was found between BCL2L12-A transcript expression and nodal status, as well as Dukes' stage. The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression.
authors.affiliation: G. Papanicolaou Research Center of Oncology, Saint Savas Hospital, GR-11522 Athens, Greece.
authors.forename: Konstantina
authors.initials: K
authors.lastname: Mathioudaki
authors.forename: Andreas
authors.initials: A
authors.lastname: Scorilas
authors.forename: Alexandra
authors.initials: A
authors.lastname: Papadokostopoulou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Xynopoulos
authors.forename: Niki
authors.initials: N
authors.lastname: Arnogianaki
authors.forename: Niki
authors.initials: N
authors.lastname: Agnanti
authors.forename: Maroulio
authors.initials: M
authors.lastname: Talieri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000502:physiology*; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D005819:Genetic Markers / Q000235:genetics / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009124:Muscle Proteins / Q000096:biosynthesis* / Q000235:genetics; D016016:Proportional Hazards Models; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D018709:Statistics, Nonparametric
chemical_list: C430100:BCL2L12 protein, human; D005819:Genetic Markers; D009124:Muscle Proteins; D020033:Protein Isoforms; D019253:Proto-Oncogene Proteins c-bcl-2