Haem oxygenase-1 in inflammation.
HO-1 (haem oxygenase-1) is a stress-inducible enzyme that plays a protective role in inflammation. Pro-inflammatory mediators, including lipopolysaccharide and cytokines, induce HO-1 expression. The 5'-flanking region of the HO-1 gene contains binding sites for the transcription factors that regulate inflammation, including nuclear factor-kappaB and activator protein 1. However, these do not appear to mediate lipopolysaccharide-induced HO-1 gene expression. In response to haem and antioxidants, murine HO-1 is regulated by the transcription factor Nrf2 (NF-E2-related factor 2). This transcription factor may also be important in the regulation of HO-1 by pro-inflammatory stimuli.
Rushworth
S A
SA
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK.
O'Connell
M A
MA
D020121:5' Untranslated Regions / Q000235:genetics; D000818:Animals; D015971:Gene Expression Regulation, Enzymologic; D006419:Heme Oxygenase (Decyclizing) / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051547:Heme Oxygenase-1; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000503:physiopathology*; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout
D020121:5' Untranslated Regions; D008565:Membrane Proteins; C496541:HMOX1 protein, human; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse