Polyunsaturated fatty acid regulation of gene expression.
Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-alpha, HNF-4alpha, and LXRalpha in mediating the nuclear effects of PUFAs are addressed.
Sampath
Harini
H
Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA.
Ntambi
James M
JM
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D004790:Enzyme Induction / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000502:physiology; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology / Q000502:physiology; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D051557:Hepatocyte Nuclear Factor 4; D006801:Humans; D008055:Lipids / Q000096:biosynthesis; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D010750:Phosphoproteins / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D051780:Sterol Regulatory Element Binding Protein 1; D051782:Sterol Regulatory Element Binding Protein 2; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; C496592:HNF4A protein, human; D051557:Hepatocyte Nuclear Factor 4; D008055:Lipids; D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors; D010750:Phosphoproteins; D018160:Receptors, Cytoplasmic and Nuclear; C497387:SREBF1 protein, human; C497390:SREBF2 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D051782:Sterol Regulatory Element Binding Protein 2; D014157:Transcription Factors