title: Hypoglycemia associated with preoperative metoprolol administration.
abstract: Perioperative beta(1)-selective-adrenergic antagonist administration has been shown to decrease morbidity and mortality in patients with cardiac disease undergoing surgical procedures. We report a case of a patient receiving the selective beta(1)-adrenergic antagonist, metoprolol, immediately before surgery that was associated with severe hypoglycemia. We postulate that an underlying abnormality in energy requirements or metabolism may allow for beta(1)-selective-adrenergic antagonists to precipitate hypoglycemia.
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Brown
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Brown
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008790:Metoprolol / Q000009:adverse effects*; D008875:Middle Aged; D011013:Pneumonectomy; D011300:Preoperative Care; D013899:Thoracic Neoplasms / Q000601:surgery
chemical_list: D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D008790:Metoprolol; D005947:Glucose