An unusual case of Behçet's syndrome: triggered by typhoid vaccination?
A case of Behçet's syndrome in a 32-year-old woman occurring shortly after her third vaccination against typhoid fever is described. Scleritis and pyoderma gangrenosum were unusual manifestations of BS that occurred in this case. Treatment benefit was provided by mycophenolate mofetil and etanercept. As bacterial antigens have been proposed as potential triggers for the onset of BS, it is possible that the syndrome was precipitated by typhoid vaccination in this patient.
Molloy
E S
ES
Department of Rheumatology, Mater Misericordiae Hospital, Dublin, Ireland. emolloy2@rcsi.ie
Powell
F C
FC
Doran
M F
MF
Ryan
J G
JG
Mulligan
N J
NJ
McCarthy
C J
CJ
Keogan
M T
MT
McCarthy
G M
GM
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications / Q000209:etiology* / Q000473:pathology; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D015423:Scleritis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000009:adverse effects*; D014611:Vaccination / Q000009:adverse effects*
D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D018124:Receptors, Tumor Necrosis Factor; D014436:Typhoid-Paratyphoid Vaccines; D009173:Mycophenolic Acid; D000068800:Etanercept