title: [Liver regeneration after resection: molecular and cellular mechanism].
abstract: It has been well established that the liver can regenerate after resection. Liver regeneration is a fundamental mechanism by which the liver responds to injury. This review article discusses molecular and cellular mechanism of liver regeneration, including growth factors and cytokines in the initiation and regulation of liver regeneration, the importance of the liver extracellular matrix and its dynamic effect on hepatocyte growth, and finally, stem cell biology in liver regeneration.
authors.affiliation: Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Wakabayashi
authors.forename: Motohide
authors.initials: M
authors.lastname: Shimazu
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ueda
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanabe
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawachi
authors.forename: Masaki
authors.initials: M
authors.lastname: Kitajima
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D004247:DNA / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000502:physiology; D022781:Hepatocytes / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D008115:Liver Regeneration / Q000235:genetics* / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D050796:STAT3 Transcription Factor; D013234:Stem Cells / Q000166:cytology; D015534:Trans-Activators / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology; D000097782:NF-kappaB-Inducing Kinase
chemical_list: D004247:DNA; D004268:DNA-Binding Proteins; D017228:Hepatocyte Growth Factor; D015850:Interleukin-6; D017346:Protein Serine-Threonine Kinases; D050796:STAT3 Transcription Factor; D015534:Trans-Activators; D014409:Tumor Necrosis Factor-alpha; D014568:Urokinase-Type Plasminogen Activator; D000097782:NF-kappaB-Inducing Kinase; C494086:STAT3 protein, human