Associations between CYP11B2 gene -344T/C polymorphism and essential hypertension in the Han nationality in Shandong province.
OBJECTIVE
To investigate whether the -344T/C polymorphism of CYP11B2 gene is associated with essential hypertension in the Hans in Shandong province.


METHODS
Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured with radioimmunoassays; the hypertensives were classified as low-renin and normal- or high-renin group by PAC/PRA ratio. -344T/C polymorphism was determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) in controls and hypertensives.


RESULTS
No significant differences were found in genotype distribution or allele frequency between groups of control and primary hypertension or between groups of control and normal- or high-renin hypertension. The C allele frequency in low-renin hypertension group was significantly higher than that in normotensives and normal- or high-renin hypertension group (P < 0.05).


CONCLUSIONS
These results suggest that -344T/C polymorphism of CYP11B2 gene may be associated with low-renin essential hypertension in the Han nationality in Shandong province.
Sun
Xiao-jian
XJ
Department of Cardiology, Yuhuangding Hospital of Qingdao University, Yantai, Shandong, PR China. sunxiaojian2002@hotmail.com
Hou
Xiao-fei
XF
Liu
Shao-rong
SR
Liu
Wen-bo
WB
Tao
Zhi-gang
ZG
Li
Jian-yuan
JY
D044466:Asian People / Q000235:genetics; D002681:China; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D019405:Cytochrome P-450 CYP11B2