title: The enteric toxins of Clostridium perfringens.
abstract: The Gram-positive pathogen Clostridium perfringens is a major cause of human and veterinary enteric disease largely because this bacterium can produce several toxins when present inside the gastrointestinal tract. The enteric toxins of C. perfringens share two common features: (1) they are all single polypeptides of modest (approximately 25-35 kDa) size, although lacking in sequence homology, and (2) they generally act by forming pores or channels in plasma membranes of host cells. These enteric toxins include C. perfringens enterotoxin (CPE), which is responsible for the symptoms of a common human food poisoning and acts by forming pores after interacting with intestinal tight junction proteins. Two other C. perfringens enteric toxins, epsilon-toxin (a bioterrorism select agent) and beta-toxin, cause veterinary enterotoxemias when absorbed from the intestines; beta- and epsilon-toxins then apparently act by forming oligomeric pores in intestinal or extra-intestinal target tissues. The action of a newly discovered C. perfringens enteric toxin, beta2 toxin, has not yet been defined but precedent suggests it might also be a pore-former. Experience with other clostridial toxins certainly warrants continued research on these C. perfringens enteric toxins to develop their potential as therapeutic agents and tools for cellular biology.
authors.affiliation: University of Pittsburgh School of Medicine, Department of Molecular Genetics and Biochemistry, Pittsburgh, PA 15261, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Smedley
authors.forename: D J
authors.initials: DJ
authors.lastname: Fisher
authors.forename: S
authors.initials: S
authors.lastname: Sayeed
authors.forename: G
authors.initials: G
authors.lastname: Chakrabarti
authors.forename: B A
authors.initials: BA
authors.lastname: McClane
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis / Q000737:chemistry / Q000633:toxicity*; D003016:Clostridium perfringens / Q000378:metabolism*; D004768:Enterotoxins / Q000096:biosynthesis / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins