title: Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle.
abstract: OBJECTIVE
  To determine the presence of proteins related to proliferation (Ki-67) and apoptosis (Bcl-2, p53) in endometrial polyps and normal endometrium during the menstrual cycle.
  
  
  METHODS
  Retrospective study using paraffin embedded tissue.
  
  
  METHODS
  Hospital affiliated to the university.
  
  
  METHODS
  Premenopausal patients with endometrial polyps.
  
  
  METHODS
  Seventy-eight premenopausal patients in different phases of the menstrual cycle were submitted to polypectomy using the Bettocchi hysteroscope. Immunohistochemistry was used to detect the expression of these proteins in endometrial polyps. One hundred and eighteen normal endometrial biopsies were used as controls.
  
  
  METHODS
  Detection of Bcl-2 and Ki-67 expression by immunohistochemistry.
  
  
  RESULTS
  In endometrial polyps, Ki-67, p53 and Bcl-2 expression was detected with more frequency during the proliferative than during the luteal phase of the cycle. Similar findings were observed in the normal endometrium.
  
  
  CONCLUSIONS
  Endometrial polyps undergo cyclic changes in the expression of their proteins related to proliferation and apoptosis during the menstrual cycle, similar to those of the cycling endometrium.
authors.affiliation: CEPARH, Rua Caetano Moura 35, 402310-341 Salvador, Bahia, Brazil.
authors.forename: Hugo
authors.initials: H
authors.lastname: Maia
authors.forename: Amélia
authors.initials: A
authors.lastname: Maltez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Studart
authors.forename: Célia
authors.initials: C
authors.lastname: Athayde
authors.forename: Elsimar M
authors.initials: EM
authors.lastname: Coutinho
mesh_terms: D000328:Adult; D017209:Apoptosis; D049109:Cell Proliferation; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008597:Menstrual Cycle / Q000502:physiology*; D011127:Polyps; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014591:Uterine Diseases / Q000378:metabolism*
chemical_list: D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53