title: Spatially resolved imaging of myocardial function with strain-encoded MR: comparison with delayed contrast-enhanced MR imaging after myocardial infarction.
abstract: Strain-encoded magnetic resonance (MR) imaging was prospectively evaluated for direct imaging of systolic myocardial strain and compared with cross-registered delayed contrast material-enhanced MR imaging in five healthy volunteers and nine patients with infarction. Local contractile performance was decreased in infarcted myocardium versus that in remote and adjacent myocardium (P < .01) and in adjacent versus remote myocardium (P < .05). The extent of dysfunctional myocardium, as assessed with strain-encoded MR imaging, was greater than that of hyperenhancement, as assessed with delayed contrast-enhanced MR imaging (P < .05). Strain values obtained with strain-encoded MR imaging were strongly correlated with those obtained with three-dimensional tagged MR imaging (r = 0.75, P < .001). Strain-encoded MR imaging provides spatially resolved (1.5 x 2.5-mm) imaging and measurement of myocardial strain in humans without the need for postprocessing, which may improve routine comprehensive evaluation of myocardial viability.
authors.affiliation: Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA. jgarot@free.fr.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Garot
authors.forename: João A C
authors.initials: JA
authors.lastname: Lima
authors.forename: Bernhard L
authors.initials: BL
authors.lastname: Gerber
authors.forename: Smita
authors.initials: S
authors.lastname: Sampath
authors.forename: Kathy C
authors.initials: KC
authors.lastname: Wu
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Prince
authors.forename: Nael F
authors.initials: NF
authors.lastname: Osman
mesh_terms: D005260:Female; D019786:Gadolinium DTPA; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*
chemical_list: D019786:Gadolinium DTPA