title: A food chain model to predict the levels of lipophilic organic contaminants in humans.
abstract: A fugacity-based, nonsteady state, mechanistic model called ACC-HUMAN was developed to describe bioaccumulation of lipophilic organic pollutants from air, water, and soil to humans. The physical environment was linked via a marine and an agricultural food chain model to a human bioaccumulation model. Contaminant uptake via the primary dietary sources of persistent lipophilic contaminants in industrialized countries was addressed, namely fish, dairy products, and beef. In addition, uptake from air and water was considered, allowing the model also to treat less lipophilic compounds. To evaluate the model, the food chain characteristics were parameterized for southern Sweden and historical scenarios of polychlorinated biphenyl (PCB) concentrations in air, water, and soil in this region were constructed from published data. The resulting model predictions of PCB concentrations in fish, milk, beef, and human tissue agreed well with measured concentrations from Swedish monitoring programs. This suggests that ACC-HUMAN is a useful tool for predicting human exposure to bioaccumulative organic compounds. It can be linked easily to existing multimedia fate and transport models.
authors.affiliation: Baltic Sea Research Institute, Rostock, Germany.
authors.forename: Gertje
authors.initials: G
authors.lastname: Czub
authors.forename: Michael S
authors.initials: MS
authors.lastname: McLachlan
mesh_terms: D000383:Agriculture; D000818:Animals; D004032:Diet; D004785:Environmental Pollutants / Q000032:analysis* / Q000493:pharmacokinetics*; D020387:Food Chain; D005506:Food Contamination; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008895:Milk, Human / Q000737:chemistry; D008962:Models, Theoretical; D009930:Organic Chemicals; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000493:pharmacokinetics; D018570:Risk Assessment; D012995:Solubility; D013548:Sweden
chemical_list: D004785:Environmental Pollutants; D008055:Lipids; D009930:Organic Chemicals; D011078:Polychlorinated Biphenyls