title: Global distribution of Streptococcus pneumoniae serotypes isolated from paediatric patients during 1999-2000 and the in vitro efficacy of telithromycin and comparators.
abstract: Few data exist on the distribution of Streptococcus pneumoniae serotypes in many countries and in non-invasive disease overall. Here, data are presented from 772 paediatric isolates from children with community-acquired respiratory tract infections isolated from the PROTEKT global surveillance study during 1999-2000. Overall, 60.0 % of isolates were covered by the 7-valent pneumococcal vaccine formulation (PCV7), with greater coverage in the USA compared with Europe (69.6 vs 55.5 %, P = 0.014). Geographically dispersed clones of serogroups 3, 11 and 15 accounted for most of the isolates outside PCV7 coverage. Overall, macrolide, penicillin and cotrimoxazole non-susceptibility rates were high; however, all isolates were susceptible to telithromycin. Although only 7.4 % of isolates were resistant to amoxycillin/clavulanate, a higher prevalence of resistance was found in isolates from the USA and South Korea. This study shows the feasibility and importance of serotyping antibiotic surveillance study isolates and the potential of telithromycin as an important option for empiric therapy.
authors.affiliation: Medical and Molecular Microbiology, GR Micro Limited, 7-9 William Road, London NW1 3ER, UK 2Carolinas Medical Center, Charlotte, NC, USA 3Institute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany.
authors.forename: D J
authors.initials: DJ
authors.lastname: Farrell
authors.affiliation: Medical and Molecular Microbiology, GR Micro Limited, 7-9 William Road, London NW1 3ER, UK 2Carolinas Medical Center, Charlotte, NC, USA 3Institute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany.
authors.forename: S G
authors.initials: SG
authors.lastname: Jenkins
authors.affiliation: Medical and Molecular Microbiology, GR Micro Limited, 7-9 William Road, London NW1 3ER, UK 2Carolinas Medical Center, Charlotte, NC, USA 3Institute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany.
authors.forename: R R
authors.initials: RR
authors.lastname: Reinert
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D001769:Blood / Q000382:microbiology; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D048628:Ketolides / Q000494:pharmacology*; D022401:Meningococcal Vaccines / Q000276:immunology; D008826:Microbial Sensitivity Tests; D009305:Nasopharynx / Q000382:microbiology; D011008:Pneumococcal Infections / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000276:immunology; D012141:Respiratory Tract Infections / Q000382:microbiology; D012703:Serotyping; D013183:Sputum / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D048628:Ketolides; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines; C106791:telithromycin