Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species.
Agar dilution MIC was used to compare activities of OPT-80, linezolid, vancomycin, teicoplanin, quinupristin/dalfopristin, amoxicillin/clavulanate, imipenem, clindamycin, and metronidazole against 350 gram-positive and -negative anaerobes. OPT-80 was active against gram-positive strains only, especially Clostridium spp. (85 strains tested, including 21 strains of C. difficile), with MICs ranging between </=0.016 and 0.25 microg/ml.
Credito
Kim L
KL
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Appelbaum
Peter C
PC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D003013:Clostridium / Q000187:drug effects; D006027:Glycosides / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D006027:Glycosides; C487655:OPT 80