[An experimental study on repair of laryngeal cartilage defect with the bone morphogenetic protein composite].
OBJECTIVE
To study the effects of the bone matrix gelatin and composite of bone morphogenetic protein and fibrin glue (BMP-FG) on the repair of thyroid cartilage defect.


METHODS
Full-thickness defects measuring 0.4 cm x 0.4 cm were created in four sections in thyroid cartilages of 20 adult dogs. The defects were divided into 4 groups by the sections they in. Group A was empty group, without implant; Group B were repaired by implanted with hydroxylapatite; Group C with bone matrix gelatin (containing BMP); Group D with bone morphogenetic protein-fibrin glue composite. The animals were killed separately at 2, 4, 12 weeks after operation. The effects of repair were analyzed by routine histological examination and electron microscope.


RESULTS
In the BMP-FG implanted group, the result showed complete absorption of the implant and substitution by new-formed cartilage and bone. The defects in the BMG group regenerated less cartilage and bone, the inflammation was sever. The gross appearance and histological features of HA group were similar to the empty group.


CONCLUSIONS
Both BMP-FG and BMG can induce cartilage and bone regeneration to repair the defect of thyroid cartilage. BMP-FG has a better effect.
Tan
Chongcai
C
Department of Otolaryngology, First Affiliated Hospital, Kunming Medical College, Kunming 650031.
Wang
Wenhui
W
Chen
Jian fei
Jf
Liu
Baoyuan
B
Na
Yuping
Y
Yuan
Biao
B
Ye
Congjun
C
Tang
Yong
Y
Hu
Peng
P
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D016723:Bone Remodeling / Q000187:drug effects; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D008297:Male; D013957:Thyroid Cartilage / Q000293:injuries / Q000601:surgery*
D019485:Bone Morphogenetic Proteins; D015718:Fibrin Tissue Adhesive