[Changes of amino acid content in hippocampus of epileptic rats treated with volatile oil of Acorus tatarinowii].
OBJECTIVE
To study the changes of excitatory and inhibitory amino acid content in hippocampus of epileptic rats treated with volatile oil of A. tatarinowii, and explore the possible antiepiletic mechanism.


METHODS
The volatile oil was extracted through Supercritical-CO2 Fluid Extraction (SFE-CO2), and epileptic models were built up by kainic acid (KA) lateral ventricle injection. The content of amino acid in hippocampus of epileptic rats treated with volatile oil was calculated.


RESULTS
The content of GABA increased and Glu decreased prominently (P < 0.05) after volatile oil 35 mg x kg(-1) intraperitoneal injection.


CONCLUSIONS
The volatile oil of A. tatarinowii can modulate the balance of excitatory and inhibitory amino acid in epileptic rats, thereby exerting its antiepileptic effect.
Chen
Li
L
Department of Neurology, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China. victoria72@sina.com
Liao
Wei-ping
WP
D029023:Acorus / Q000737:chemistry; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001224:Aspartic Acid / Q000378:metabolism; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D007608:Kainic Acid; D008297:Male; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000927:Anticonvulsants; D009822:Oils, Volatile; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D007608:Kainic Acid