title: Outbreak of dengue in Mumbai and predictive markers for dengue shock syndrome.
abstract: An alarming rise of dengue has been seen in Mumbai during the post-monsoon season. We undertook this prospective study in the pediatric wards and pediatric intensive care unit of B. J. Wadia Hospital for Children between 27 August 2003 and 10 October 2003 to determine the clinical features, laboratory abnormalities, and outcome of children affected with dengue and to determine the predictive markers for dengue shock syndrome. Fifty-one suspected dengue cases were tested for positivity of dengue by determination of dengue IgM antibodies by ELISA test. These positive cases were analysed for common clinical features, laboratory derangements, and outcome. Patients were subdivided into three subgroups: dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) as per WHO classification. Predictive markers for DSS were also determined. Thirty-nine patients had a positive dengue IgM titre, 20 patients had DHF, 18 patients had DSS, and one patient had DF The mean age of presentation was 4.9 years. Fever, hepatomegaly, vomiting, bleeding tendencies, erythematous rash, thrombocytopenia, elevated liver enzymes, and deranged PT and PTT were the predominant clinical and laboratory features. Predictive markers for DSS were younger age at onset, altered sensorium, paralytic ileus, and significantly deranged PT. Patients with DSS also had a longer recovery period and required more supportive management in the form of component therapy and ionotropic support. All three patients who died belonged to the DSS subgroup with case fatality rate for DSS being 16.6 per cent. None of the patients in the DHF or DF subgroup died. Endemicity of dengue fever is on the rise in Mumbai with increased incidence among children. Appropriate investigations, strict monitoring and prompt supportive management can reduce mortality in dengue. Predictive markers of DSS can reduce the mortality if promptly treated. Also prevention of transmission by mosquito control and maintaining water sanitation is required to effectively control this epidemic.
authors.affiliation: Department of Pediatrics, B. J. Wadia Hospital for Children, Parel, Mumbai, India. irashah86@hotmail.com
authors.forename: Ira
authors.initials: I
authors.lastname: Shah
authors.forename: G C
authors.initials: GC
authors.lastname: Deshpande
authors.forename: P N
authors.initials: PN
authors.lastname: Tardeja
mesh_terms: D000704:Analysis of Variance; D000914:Antibodies, Viral / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003716:Dengue Virus / Q000302:isolation & purification*; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D007223:Infant; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012621:Seasons; D019595:Severe Dengue / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D012772:Shock, Septic / Q000821:virology*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D015415:Biomarkers; D007075:Immunoglobulin M