[Study of propofol target controlled infusion for blind tracheal intubation in anesthesia of oral and maxillofacial surgery.].
OBJECTIVE
To observe the clinical effects of propofol target controlled infusion for blind tracheal intubation in anesthesia of oral and maxillofacial surgery.


METHODS
80 cases with difficult airway of oral and maxillofacial surgery were divided into four groups. They were intubated by a new blind tracheal intubation technique.Before intubation,group 1,group 2,group 3 received fentanyl 4 microg/kg by intravenous infusion and propofol TCI 1.0 microg/ml,1.5 microg/ml,2.0 microg/ml, respectively.Group 4 only received fentanyl 4 microg/kg. All patients underwent tracheal topical anesthesia.The effects of anesthesia in the four groups were observed and compared.


RESULTS
Ramsay score in group 2 and group 3 was obviously higher after administer propofol TCI (P<0.05).During intubation, group 2 and group 3 kept higher score than the other groups (P<0.05), MAP and HR changed smoothly and steadily in group 2 and group 3. But in group 1 and group 4, MAP and HR increased significantly (P<0.05). During intubation, RR decreased significantly in the four groups, but most serious in group 3 (P<0.05).There were no significant changes of SpO2, P(ET)CO2. After intubation, plasma PRL and plasma A II increased obviously in different degrees in the four groups,the increase in group 4 was higher than in group 3 (P<0.05).


CONCLUSIONS
Propofol target controlled infusion is a good anesthesia method for blind tracheal intubation.It is safe and effective if target blood concentration controlled appropriately.
Jiang
Hong
H
Department of Anesthesiology, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China. dozhujh@online.sh.cn
Zhu
Ye-Sen
YS
D000768:Anesthesia, General / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D013515:Surgery, Oral / Q000379:methods*
D018686:Anesthetics, Intravenous; D015742:Propofol