title: Changes in the steady-state potential in rats with focal cerebral ischemia receiving cyclopentyladenosine.
abstract: Brain function and neuroprotective activity of cyclopentyladenosine in rats with focal cerebral ischemia were evaluated by recording the steady-state potential. Cerebral ischemia was modeled by intravasal occlusion of the left internal carotid and middle cerebral arteries and bilateral occlusion of the common carotid arteries. Recording of the steady-state brain potential during experimental ischemia allowed identifying the development of ischemic depolarization by a negative potential shift. Changes in the steady-state potential after cyclopentyladenosine administration reflected delayed development of ischemic depolarization in the nervous tissue. Cyclopentyladenosine holds much promise for the protection of nerve cells from ischemic injury.
authors.affiliation: Department of Pharmacology, Irkutsk State Medical University. neuro@medk.baikal.ru
authors.forename: G Z
authors.initials: GZ
authors.lastname: Sufianova
authors.forename: S E
authors.initials: SE
authors.lastname: Murik
authors.forename: L A
authors.initials: LA
authors.lastname: Usov
authors.forename: A A
authors.initials: AA
authors.lastname: Sufianov
authors.forename: A G
authors.initials: AG
authors.lastname: Shapkin
authors.forename: M V
authors.initials: MV
authors.lastname: Taborov
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000241:Adenosine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D008297:Male; D008839:Microelectrodes; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology; D051381:Rats; D013997:Time Factors
chemical_list: D018696:Neuroprotective Agents; D000241:Adenosine