title: Preparation of benzolactams by Pd(OAc)2-catalyzed direct aromatic carbonylation.
abstract: We developed a new method for Pd(II)-catalyzed direct aromatic carbonylation in a phosphine-free catalytic system using Pd(OAc)2 and Cu(OAc)2 in an atmosphere of CO gas containing air. The carbonylation proceeded with ortho-palladation, inducing a remarkable site selectivity to afford a variety of five- or six-membered benzolactams from secondary omega-arylalkylamines, such as N-alkylbenzylamines or N-alkylphenethylamines.
authors.affiliation: Laboratory of Organic Synthesis, Division of Molecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan. orito@org-mc.eng.hokudai.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Orito
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Horibata
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Harumi
authors.initials: H
authors.lastname: Ushito
authors.forename: Hideo
authors.initials: H
authors.lastname: Nagasaki
authors.forename: Motoki
authors.initials: M
authors.lastname: Yuguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamashita
authors.forename: Masao
authors.initials: M
authors.lastname: Tokuda