title: Low-temperature deacylation of N-monosubstituted amides.
abstract: [reaction: see text] The (PhO)(3)P.Cl(2) reagent, prepared in situ by titrating a solution of triphenyl phosphite with chlorine, is used to convert N-monosubstituted amides into their corresponding amines. The reaction, if compared to other traditional methods, shows the advantage of very mild conditions and low temperature (-30 degrees C-->rt).
authors.affiliation: Dipartimento di Chimica, Università di Modena e Reggio Emilia, via Campi 183-41100 Modena, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Spaggiari
authors.forename: Larry C
authors.initials: LC
authors.lastname: Blaszczak
authors.forename: Fabio
authors.initials: F
authors.lastname: Prati
mesh_terms: D000215:Acylation; D000577:Amides / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002713:Chlorine / Q000737:chemistry; D003080:Cold Temperature; D008956:Models, Chemical; D017905:Phosphites / Q000737:chemistry; D013696:Temperature
chemical_list: D000577:Amides; D017905:Phosphites; D002713:Chlorine; C013318:triphenyl phosphite