Pulmonary alveolar proteinosis associated with psoriasis and complicated by mycobacterial infection: successful treatment with granulocyte-macrophage colony stimulating factor after a partial response to whole lung lavage.
Pulmonary alveolar proteinosis (PAP) is a rare lung disease. Although whole lung lavage is considered the most effective treatment, not every patient shows a complete response. The case ofa young man with PAP in association with psoriasis who underwent frequent whole lung lavage but only achieved remission following treatment with granulocyte-macrophage colony stimulating factor (GM-CSF) is reported. His lung problem was complicated by atypical mycobacterial infection,which resolved with treatment. The role of GM-CSF is discussed.
Abdul Rahman
Jamalul Azizi
JA
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. alamine@pd.jaring.my
Moodley
Yuben P
YP
Phillips
Martin J
MJ
D000328:Adult; D018893:Bronchoalveolar Lavage; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications*; D019909:Mycobacterium kansasii; D011565:Psoriasis / Q000150:complications*; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D012074:Remission Induction; D019233:Retreatment
D016178:Granulocyte-Macrophage Colony-Stimulating Factor