title: Antimicrobial susceptibility profiles of Pseudomonas aeruginosa and Staphylococcus aureus isolated in Italy from patients with hospital-acquired infections.
abstract: Here we report the results of the Sentinel Project 2000 and give the susceptibility to selected antibiotics of 108 Pseudomonas aeruginosa and 108 Staphylococcus aureus strains isolated from patients with hospital-acquired lower respiratory tract infections. In P. aeruginosa, susceptibility to aztreonam and ciprofloxacin was lower than 50%. The resistance rate to beta-lactams was up to 25% and to amikacin 15.7%. Blood isolates showed 80-90% susceptibility to all antibiotics tested except for aztreonam and tobramycin. Overall, oxacillin resistance in S. aureus was 45%, reaching 64.3% among the bronchoalveolar lavage isolates, and 42.9% among the blood isolates. These worrying results confirm the need for continuous monitoring of bacterial resistance trends in the hospitals, mainly in ICUs.
authors.affiliation: Department of Microbiological and Gynecological Sciences, University of Catania, Via Androne, 83/8595100 Catania, Italy. blandino@mbox.unict.it
authors.forename: G
authors.initials: G
authors.lastname: Blandino
authors.forename: A
authors.initials: A
authors.lastname: Marchese
authors.forename: F
authors.initials: F
authors.lastname: Ardito
authors.forename: G
authors.initials: G
authors.lastname: Fadda
authors.forename: R
authors.initials: R
authors.lastname: Fontana
authors.forename: G
authors.initials: G
authors.lastname: Lo Cascio
authors.forename: F
authors.initials: F
authors.lastname: Marchetti
authors.forename: G C
authors.initials: GC
authors.lastname: Schito
authors.forename: G
authors.initials: G
authors.lastname: Nicoletti
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D007558:Italy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012141:Respiratory Tract Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams