title: Keratin mutations and intestinal pathology.
abstract: Whilst the importance of mutations in a wide range of keratins in skin fragility disorders is now well established, there is much less evidence for simple epithelial keratin involvement in disease. Some simple epithelial keratin mutations have been reported in liver cirrhosis and pancreatitis patients, and recently mutations in the simple epithelial keratin K8 were identified in a group of patients with inflammatory bowel disease (Crohn disease or ulcerative colitis). In comparison with the mutations seen in epidermal keratins, these simple epithelial mutations would be predicted to have mild consequences, although analysis shows that they do have a distinct effect. This review article discusses the evidence that these mutations are a predisposing factor for inflammatory bowel disease.
authors.affiliation: Cancer Research UK Cell Structure Research Group, Division of Cell and Developmental Biology, University of Dundee School of Life Sciences, MSI/WTB Complex, Dow Street, Dundee DD1 5EH, UK. d.w.owens@dundee.ac.uk
authors.forename: D W
authors.initials: DW
authors.lastname: Owens
authors.forename: E B
authors.initials: EB
authors.lastname: Lane
mesh_terms: D003106:Colon / Q000473:pathology; D003599:Cytoskeleton / Q000473:pathology; D004847:Epithelial Cells / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000473:pathology; D053538:Keratin-18; D053533:Keratin-8; D007633:Keratins / Q000235:genetics*; D009154:Mutation; D013314:Stress, Mechanical
chemical_list: C488421:KRT18 protein, human; C426203:KRT8 protein, human; D053538:Keratin-18; D053533:Keratin-8; D007633:Keratins