[Study on the expression of proto-oncogene eIF4E in laryngeal squamous carcinoma].
OBJECTIVE
To investigate the expression of the proto-oncogene eIF4E in laryngeal squamous cell carcinoma and its relationship with clinical pathology.


METHODS
Sections of 37 samples of laryngeal squamous cell carcinoma (LSCC) and 10 samples of vocal cords polyp were analyzed with anti-eIF4E polyclonal antibody utilizing SP (Streptavidin Peroxidase) immunohistochemical technique.


RESULTS
All 37 LSCC samples overexpressed eIF4E in the tumors (eIF4E score: 30 approximately 210), whereas no staining was observed in 10 samples of vocal cords polyp (eIF4E score: 0). There was a significant correlation between overexpression of protein eIF4E with T stage, N stage, histological grade, recurrence and the states of metastases (P < 0.01). It did not correlate with age, sex, and site of tumor (P > 0.05).


CONCLUSIONS
The eIF4E plays an important role on tumorgenesis, development, invasion and metastases of laryngeal squamous cell carcinoma. There was a correlation between the overexpression of protein eIF4E with TNM stage, histological grade, recurrence and metastases. eIF4E in the laryngeal squamous cell carcinoma can be considered as an independent prognostic factor and tumour molecular marker.
Tao
Lei
L
Department of Otolaryngology-Head and Neck Surgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200001.
Zhou
Liang
L
Zheng
Luying
L
Gao
Yuping
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D039561:Eukaryotic Initiation Factor-4E / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D000090063:Proto-Oncogene Mas
D039561:Eukaryotic Initiation Factor-4E; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas