Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis.
Vincent
Florence
F
Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York, YO10 5YW, UK.
Gloster
Tracey M
TM
Macdonald
James
J
Morland
Carl
C
Stick
Robert V
RV
Dias
Fernando M V
FM
Prates
José A M
JA
Fontes
Carlos M G A
CM
Gilbert
Harry J
HJ
Davies
Gideon J
GJ
D044602:Cellulases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006868:Hydrolysis; D050112:Imino Pyranoses; D007700:Kinetics; D007769:Lactams / Q000494:pharmacology; D008968:Molecular Conformation; D010880:Piperidines / Q000494:pharmacology*; D011714:Pyrans / Q000737:chemistry*; D044902:beta-Mannosidase / Q000037:antagonists & inhibitors* / Q000737:chemistry
D004791:Enzyme Inhibitors; D050112:Imino Pyranoses; D007769:Lactams; D010880:Piperidines; D011714:Pyrans; C098432:isofagomine; D044602:Cellulases; D044902:beta-Mannosidase