title: [The effect of dalargin and des-Tyr-dalargin on the functional state of intact and ischemized-reperfused myocardium].
abstract: Experiments on isolated perfused rat heart showed that dalargin, an antagonist of mu- and delta-opioid receptors, favors a decrease in the parameters of contractility of intact myocardium, while not influencing the pumping function (systolic and diastolic contractility) of reperfused myocardium. At the same time, des-Tyr-dalargin (the non-opioid analog of dalargin) suppresses the contractility of both the intact heart and the isolated myocardium subjected to global ischemia and reperfusion. Both dalargin and des-Tyr-dalargin reduced the incidence of reperfusion-induced arrhythmia, but did not affect the coronary flow before ischemia and after restoration of the coronary flow. It is suggested that the effect of dalargin is related to activation of the cardiac delta-opioid receptors, while the inotropic action of des-Tyr-dalargin involves other receptor mechanisms.
authors.forename: T V
authors.initials: TV
authors.lastname: Lasukova
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
authors.forename: M V
authors.initials: MV
authors.lastname: Ovchinnikov
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Bespalova
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Podoksenov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Podoksenov
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors
chemical_list: D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; C497517:dalargin, destyrosyl-; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-