title: [Human papillomavirus oncogenicity and grade of anal intraepithelial neoplasia in HIV positive patients].
abstract: OBJECTIVE
  We decided to evaluate if grade of anal intraepithelial neoplasia (AIN) was associated to the HPV type in HIV positive patients, since this group of patients has immunodeficiency over long periods. We identified HPV types by PCR (polimerase chain reaction) and histological examination to determine the AIN grade in 39 HIV positive males with anal condylomata acuminata.
  
  
  RESULTS
  We observed high grade AIN (HAIN) in 9 (23.1 percent) and low grade AIN (LAIN) in 30 patients (76.9 percent). The most frequent HPV types were 6 and 11 (64 percent) and oncogenic types 16, 18 and 31 appeared in 20.5 percent of patients. We could not identify viral type in four patients (10.2 percent) despite tests revealing presence of viral deoxiribonucleic acid. Comparing AIN grades with viral types we observed that non-oncogenic types can also be associated with HAIN lesions.
  
  
  CONCLUSIONS
  These results allowed us to conclude that both oncogenic and non-oncogenic HPV types can be associated with HAIN lesions in HIV positive patients.
authors.affiliation: Seção de Patologia, Instituto de Infectologia Emilio Ribas, São Paulo, SP.
authors.forename: Carmen Ruth
authors.initials: CR
authors.lastname: Manzione
authors.forename: Sidney Roberto
authors.initials: SR
authors.lastname: Nadal
authors.forename: Edenilson Eduardo
authors.initials: EE
authors.lastname: Calore
mesh_terms: D000293:Adolescent; D000328:Adult; D001004:Anus Diseases / Q000821:virology; D001005:Anus Neoplasms / Q000473:pathology / Q000821:virology*; D018791:CD4 Lymphocyte Count; D002278:Carcinoma in Situ / Q000821:virology*; D016009:Chi-Square Distribution; D003218:Condylomata Acuminata / Q000821:virology; D006679:HIV Seropositivity / Q000150:complications* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies