Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms.
OBJECTIVE
Wall shear stress (WSS) is one of the main pathogenic factors in the development of saccular cerebral aneurysms. The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD).


METHODS
Twenty mathematical models of MCA vessels with aneurysms were created by 3-dimensional computed tomographic angiography. CFD calculations were performed by using our original finite-element solver with the assumption of Newtonian fluid property for blood and the rigid wall property for the vessel and the aneurysm.


RESULTS
The maximum WSS in the calculated region tended to occur near the neck of the aneurysm, not in its tip or bleb. The magnitude of the maximum WSS was 14.39+/-6.21 N/m2, which was 4-times higher than the average WSS in the vessel region (3.64+/-1.25 N/m2). The average WSS of the aneurysm region (1.64+/-1.16 N/m2) was significantly lower than that of the vessel region (P<0.05). The WSSs at the tip of ruptured aneurysms were markedly low.


CONCLUSIONS
These results suggest that in contrast to the pathogenic effect of a high WSS in the initiating phase, a low WSS may facilitate the growing phase and may trigger the rupture of a cerebral aneurysm by causing degenerative changes in the aneurysm wall. The WSS of the aneurysm region may be of some help for the prediction of rupture.
Shojima
Masaaki
M
Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan. mshoji-tky@umin.ac.jp
Oshima
Marie
M
Takagi
Kiyoshi
K
Torii
Ryo
R
Hayakawa
Motoharu
M
Katada
Kazuhiro
K
Morita
Akio
A
Kirino
Takaaki
T
D000368:Aged; D017542:Aneurysm, Ruptured / Q000503:physiopathology*; D002533:Cerebral Angiography; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological