title: Tolerability of the Intergroup 0099 (INT 0099) regimen in locally advanced nasopharyngeal cancer with a focus on patients' nutritional status.
abstract: OBJECTIVE
  The Intergroup 0099 trial (INT 0099) for locally advanced nasopharyngeal cancer (NPC) has set a standard of practice. This retrospective review documents our institutional experience with this regimen.
  
  
  METHODS
  For all NPC patients treated between January 1998 and December 2002 with the INT 0099 regimen, compliance, toxicity, weight change, and feeding tube use were recorded. Patients were grouped by therapy completion status and by feeding tube status.
  
  
  RESULTS
  Of 78 consecutive patients, 75 were evaluable. Compliance with radiotherapy was excellent. Only 43% and 61% of patients received all cycles of concurrent and adjuvant chemotherapy, respectively. Patients who successfully completed therapy had a higher average baseline weight and were more likely to have had a prophylactic feeding tube. Forty of 75 patients had a feeding tube inserted and were analyzed as two groups. Patients with prophylactic insertion (n = 23) had a more gradual drop in weight, and recovered to a greater degree at 1 year (93.6% vs. 87.2%), than those with a feeding tube inserted therapeutically during treatment (n = 17).
  
  
  CONCLUSIONS
  The INT 0099 regimen was generally delivered with modifications to the chemotherapy component, as in the original trial. The prophylactic insertion of a feeding tube may facilitate therapy completion and weight recovery in some patients.
authors.affiliation: Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada.
authors.forename: Mala
authors.initials: M
authors.lastname: Bahl
authors.forename: Lillian L
authors.initials: LL
authors.lastname: Siu
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Pond
authors.forename: John
authors.initials: J
authors.lastname: Kim
authors.forename: Ian F
authors.initials: IF
authors.lastname: Tannock
authors.forename: Andrew
authors.initials: A
authors.lastname: Bayley
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: Cummings
authors.forename: John
authors.initials: J
authors.lastname: Waldron
authors.forename: Jolie
authors.initials: J
authors.lastname: Ringash
authors.forename: Eric X
authors.initials: EX
authors.lastname: Chen
authors.forename: Leah
authors.initials: L
authors.lastname: Gitterman
authors.forename: Betty
authors.initials: B
authors.lastname: Lemon
authors.forename: Brian
authors.initials: B
authors.lastname: O'Sullivan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D004750:Enteral Nutrition; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009752:Nutritional Status; D012189:Retrospective Studies; D015431:Weight Loss