[Pediatric liver transplantation--experience at Schneider Children's Medical Center].
BACKGROUND
Introduction of segmental graft transplantation from living donors and split livers from cadaver donors has led to major advances in liver transplantation (LTx) in children.


OBJECTIVE
To report our initial experience with pediatric LTx performed at our center.


METHODS
Data collection on all children undergoing LTx between the years 1996-2003 including the analysis of the graft and patient survivals and reports of complications.


RESULTS
Forty LTx were performed in 38 children at the mean age of 6.2 years, including two retransplants. There were 15 whole liver allografts and 25 segmental grafts including: 12 living donor grafts, 5 splits and 8 reduced grafts from cadaver donors. At 40 months mean follow-up period, patient and graft survival were 81% and 72.5%, respectively. There was post-transplant mortality in seven cases--5 children died during the first month and two children passed away after 6 months (recurrent disease) and 14 months (metastatic tumor). Vascular complications included: one early and one late portal vein thrombosis (5%) and six cases of hepatic artery thrombosis (15%). In the latest group, 3 grafts were salvaged by thrombectomy and another 3 children underwent re-transplantation. There were two bile leaks (5%) and 6 bile duct strictures (15%). The bile-duct strictures were successfully corrected by surgery in one child and by transhepatic dilatation in another 4 children. One child remained with intrahepatic strictures in one of the two hepatic segments.


CONCLUSIONS
The use of segmental liver allografts enables the performance of pediatric liver transplantation in Israel. Gathered experience and enhanced skills will ensure improved results over time.
Mor
Eytan
E
Department of Transplantation, Children's Gastroenterology Institute, Schneider Children's Medical Center, Petah Tikva, Israel. emor@clalit.org.il
Bar-Nathan
Nathan
N
Shaharabani
Ezra
E
Bergerin
Rachel
R
Harlev
Efrat
E
Amir
Jacob
J
Shapiro
Rivka
R
D000293:Adolescent; D002648:Child; D006085:Graft Survival; D006801:Humans; D007557:Israel; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality / Q000502:physiology; D019520:Living Donors; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods; D016896:Treatment Outcome