title: Cost effectiveness of bortezomib in the treatment of advanced multiple myeloma.
abstract: This study evaluated the cost effectiveness of bortezomib in relapsed, refractory myeloma, relative to best supportive care (BSC) and thalidomide. Data were derived from the phase 2 pivotal study of bortezomib, a Delphi panel of six myeloma thought leaders, and published literature. Objective assumptions regarding treatment choices and consequences (response and complications), and actual cost data were used. Bortezomib was found to be cost effective relative to BSC and thalidomide. Sensitivity analyses demonstrated the robustness of the results. These data suggest that bortezomib provides a cost-effective treatment option and the best value (in terms of cost/life-yr gained) among the currently available therapeutic options for relapsed, refractory myeloma.
authors.affiliation: Hematopoietic Stem Cell Transplantation Program, The Feinberg School of Medicine, Northwestern University, Chicago, USA. j-mehta@northwestern.edu
authors.forename: Jayesh
authors.initials: J
authors.lastname: Mehta
authors.forename: Steven B
authors.initials: SB
authors.lastname: Duff
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
mesh_terms: D001897:Boronic Acids / Q000009:adverse effects / Q000191:economics* / Q000627:therapeutic use*; D000069286:Bortezomib; D003362:Cost-Benefit Analysis; D003697:Delphi Technique; D017850:Economics, Pharmaceutical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D011719:Pyrazines / Q000009:adverse effects / Q000191:economics* / Q000627:therapeutic use*; D013792:Thalidomide / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib