Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine.
Protein synthesis in the cell is performed on ribosomes, large ribonucleoprotein particles, which in bacteria consist of three RNA molecules and over 50 proteins. This review summarizes recent progress in understanding the mechanisms of the elongation phase of protein synthesis. Results from rapid kinetic analysis of elongation reactions are discussed in the light of recent structural data.
Wintermeyer
W
W
Institute of Molecular Biology, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany. winterme@uni-wh.de
Peske
F
F
Beringer
M
M
Gromadski
K B
KB
Savelsbergh
A
A
Rodnina
M V
MV
D000818:Animals; D001665:Binding Sites; D003062:Codon; D019277:Entropy; D006868:Hydrolysis; D007700:Kinetics; D046911:Macromolecular Substances / Q000737:chemistry*; D008954:Models, Biological; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry; D012343:RNA, Transfer / Q000737:chemistry; D012270:Ribosomes / Q000737:chemistry* / Q000378:metabolism
D003062:Codon; D046911:Macromolecular Substances; D010455:Peptides; D011506:Proteins; D012343:RNA, Transfer