[Use of oximes in the therapy of acute intoxication by organophosphorus compounds].
The treatment of patients who consumed lethal doses of various organophosphorus compounds (OP) still remains a great challenge to clinical toxicologists. The oximes in combination with atropine and diazepam are an integral part of the treatment of acute intoxications with organophosphate. Treatment with atropine, which relieves the muscarinic effects of acetylcholine and anticonvulsive agents (diazepam) is well established. However, the effectiveness of oxime compounds in counteracting the effect of intoxication in still a matter of debate. Based on literature reports, opinions are presented concerning the role of oximes in the treatment of intoxications by various OP.
Raszewski
Grzegorz
G
Zakład Diagnostyki Laboratoryjnej Instytut Medycyny Wsi w Lublinie. grasz@galen.imw.lublin.pl
Filip
Rafal
R
D000927:Anticonvulsants / Q000627:therapeutic use; D001285:Atropine / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000506:poisoning; D002801:Cholinesterase Reactivators / Q000494:pharmacology / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D006801:Humans; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010091:Oximes / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy* / Q000378:metabolism; D012307:Risk Factors
D000927:Anticonvulsants; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D018727:Muscarinic Antagonists; D009943:Organophosphorus Compounds; D010091:Oximes; D001285:Atropine; D003975:Diazepam