[Relation between vascular endothelial growth factor expression and clinical pathological character in laryngeal squamous cell carcinoma].
OBJECTIVE
To approach the relation between vascular endothelial growth factor (VEGF) expression and clinical pathological character in laryngeal squamous cell carcinoma.


METHODS
Immunohistochemical staining (SP) was used to evaluated the expression of VEGF and microvessel count (MVC) in tumor tissues from 87 patients with laryngeal squamous cell carcinoma.


RESULTS
VEGF immune response was mainly localized to the tumor cell cytoplasm, positive rate was 77%. In laryngeal squamous cell carcinoma, the wider the tumor invaded, the stronger VEGF expressed, the fewer the tumor invaded, the weaker VEGF expressed (P < 0.05); The lower the tumor differentiated, the stronger VEGF expressed, the higher the tumor differentiated, the weaker VEGF expressed (P < 0.05); The stronger VEGF expressed, the more MVC were (P < 0.01); The mean MVC in tumor tissues was obviously higher than that in surgical margin tissues (P < 0.01).


CONCLUSIONS
In laryngeal squamous cell carcinoma, the expression of VEGF was markedly correlated with tumor stage and differentiation, was positively correlated with MVC. As a result, VEGF may have an important role in the progression of laryngeal squamous the carcinoma.
Li
Zhengjang
Z
Department of Head and Neck Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021.
Tang
Pingzhang
P
Zhang
Zhichao
Z
Zhao
Qungzheng
Q
Lin
Dongmei
D
Xu
Zhengang
Z
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
D042461:Vascular Endothelial Growth Factor A