title: Synthesis of the tubuvaline-tubuphenylalanine (Tuv-Tup) fragment of tubulysin.
abstract: [structure: see text] Advanced intermediates and analogues of tubulysins were prepared in a convergent strategy.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takada
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rishel
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010446:Peptide Fragments / Q000138:chemical synthesis; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry*; D013237:Stereoisomerism; D014633:Valine / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009842:Oligopeptides; D010446:Peptide Fragments; C502386:tubulysin D; D010649:Phenylalanine; D014633:Valine