Object alternation test--is it sensitive enough to detect cognitive dysfunction in obsessive-compulsive disorder?
A computerized version of the object alternation test (OAT) was employed in unmedicated obsessive-compulsive disorder (OCD) patients and matched healthy controls. OCD patients performed normally on the OAT but scored below controls on a task assessing visuo-spatial working memory. The results challenge the concept of the OAT as a sensitive instrument for orbitofrontal dysfunction in OCD.
Katrin Kuelz
Anne
A
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg, Germany.
Riemann
Dieter
D
Zahn
Roland
R
Voderholzer
Ulrich
U
D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D001330:Electronic Data Processing; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology* / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index