Sensitivity increase in molecular recognition by decrease of the sensing particle size and by increase of the receptor binding site--a case with chemomechanical polymers.
For the first time it is shown that diminishing the particle size of a chemomechanical polymer leads to a dramatic sensitivity increase, with a large response triggered e.g. by action of external AMP; as illustrated with carbohydrate model complexes in solution, the necessary high binding affinity can be achieved by providing an excess of recognition units in one of the partners.
Schneider
Hans-Jörg
HJ
FR Organische Chemie and Institut für Neue Materialien, Universität des Saarlandes, D 66041, Saarbrücken, Germany. ch12hs@rz.uni-sb.de
Tianjun
Liu
L
Lomadze
Nino
N
D001665:Binding Sites; D002241:Carbohydrates / Q000737:chemistry; D008968:Molecular Conformation; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012680:Sensitivity and Specificity
D002241:Carbohydrates; D011108:Polymers