Modulation of the primary and the secondary antibody response by tobacco smoke condensates.
Cigarette smoke condensate administered to C57BL/6 mice led to a decrease in the primary antibody response to OVA (hen egg albumin) antigen. Selenium (Se)-supplementation allowed to relieve significantly this inhibition. Moreover, even being not supplemented with Se, a preparation was found devoid of inhibitory effects. Furthermore, the presence of Se-supplemented tobacco smoke condensate at the time of antigen priming, contributed to an enhanced secondary antibody response.
Nguyen Van Binh
Pascale
P
Laboratoire de Toxicologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, 75006 Paris, France.
Zhou
Dong
D
Baudouin
Françoise
F
Martin
Chantal
C
Radionoff
Martine
M
Dutertre
Hélène
H
Marchand
Véronique
V
Thevenin
Marc
M
Warnet
Jean-Michel
JM
Thien Duc
Huynh
H
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D007106:Immune Sera / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000009:adverse effects; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
D007106:Immune Sera; D007166:Immunosuppressive Agents; D014028:Tobacco Smoke Pollution; D010047:Ovalbumin