Functional genomics to new drug targets.
The completion of the sequencing of the human genome, and those of other organisms, is expected to lead to many potential new drug targets in various diseases, and it is predicted that novel therapeutic agents will be developed against such targets. The role of functional genomics in modern drug discovery is to prioritize these targets and to translate that knowledge into rational and reliable drug discovery. Here, we describe the field of functional genomics and review approaches that have been applied to drug discovery, including RNA profiling, proteomics, antisense and RNA interference, model organisms and high-throughput, genome-wide overexpression or knockdowns, and outline the future directions that are likely to yield new drug targets from genomics.
Kramer
Richard
R
Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Cohen
Dalia
D
D000818:Animals; D015195:Drug Design; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D020543:Proteome / Q000235:genetics*
D016376:Oligonucleotides, Antisense; D020543:Proteome