title: Scabrosin esters and derivatives: chemical derivatization studies and biological evaluation.
abstract: Several derivatives of the natural scabrosin esters were synthesized in order to elucidate the structural features present, which are responsible for the biological activities. The studies demonstrate that full anti-proliferative activities of the scabrosin esters, both the carboskeleton core as well as the ability to form the dithiol and/or the disulfide linkage of the epidithiopiperazine-2,5-dione are required. The presence of the epoxide rings on the scabrosin esters do not contribute to the observed biological activities.
authors.affiliation: Centre for the Study of Bioactive Molecules, Department of Chemistry, Australian National University, Canberra ACT 0200, Australia. christina.chai@anu.edu.au
authors.forename: Christina L L
authors.initials: CL
authors.lastname: Chai
authors.forename: John A
authors.initials: JA
authors.lastname: Elix
authors.forename: Paul B
authors.initials: PB
authors.lastname: Huleatt
authors.forename: Paul
authors.initials: P
authors.lastname: Waring
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis / Q000494:pharmacology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004952:Esters; D051379:Mice
chemical_list: D001685:Biological Factors; D001688:Biological Products; D004952:Esters