title: Imatinib mesylate: an attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans.
abstract: To document the clinical activity of imatinib mesyalte in a child with a dermatofibrosarcoma protuberans (DFSP). An 18-month-old girl presented with a large extremity DFSP. As surgical resection would have caused unacceptable functional defects, imatinib mesylate was administered to induce tumor reduction and or stabilization. After 23 weeks of therapy, magnetic resonance imaging (MRI) of the tumor showed a reduction in the subcutaneous thickness in the transverse plane. The drug was tolerated well without any adverse reactions. Imatinib mesylate offers a non-surgical alternative for the treatment of large DFSP in children.
authors.affiliation: Department of Pediatrics, Division Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Price
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fletcher
authors.forename: Maria
authors.initials: M
authors.lastname: Zielenska
authors.forename: William
authors.initials: W
authors.lastname: Cole
authors.forename: Sandra
authors.initials: S
authors.lastname: Viero
authors.forename: David E
authors.initials: DE
authors.lastname: Manson
authors.forename: Mary
authors.initials: M
authors.lastname: Stuart
authors.forename: Alberto S
authors.initials: AS
authors.lastname: Pappo
mesh_terms: D001549:Benzamides; D018223:Dermatofibrosarcoma / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D000068877:Imatinib Mesylate; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007866:Leg / Q000473:pathology; D008279:Magnetic Resonance Imaging; D010879:Piperazines / Q000627:therapeutic use*; D020574:Proto-Oncogene Proteins c-sis / Q000235:genetics; D011743:Pyrimidines / Q000627:therapeutic use*; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D001549:Benzamides; D010879:Piperazines; D020574:Proto-Oncogene Proteins c-sis; D011743:Pyrimidines; D000068877:Imatinib Mesylate