[The influence of pentoxifylline on the course of experimental peritonitis].
The influence and relation between pentoxifylline (PTX) dose and time of administration and mortality rate of animals with experimental peritonitis (EP) were studied. Forty-five rats used in this study. Experimental peritonitis was elicited in study animals. All animals were divided onto 3 groups. The sorting was made according to drug dose and moment of administration. Group 1--the control one--consisted of non-treated animals with EP. Animals from group 2 received 50 mg of PTX per kg of body weight before cecal ligation and puncture (CLP). In group 3 PTX was administered in a dose of 250 mg/kg 8 hrs after CLP. The influence of PTX inactivating phosphodiestherase as a cyclooxigenas inhibitor on the behavior of C-reactive protein, II-11beta, TNFalph and its soluble sTNF-R type I p55 and type II p75 receptors' study animal serum concentrations was estimated. The influence of administered drugs on the course of EP was assessed by means of animal survival period and CRP serum concentration dynamics observation. Thirty-three percent of control group animals survived the experiment compared to 53.3% in group 2 and 46.6% in group 3. The study proved that PTX administration in animals with EP caused TNFa serum concentration decrease, however not changing the overall animal survival rate. On the contrary, cycloooxygenase inhibitors decrease arachidonic acid peroxidation product cytotoxicity in experimental peritonitis.
Modzelewski
Bogdan
B
Klinika Chirurgii Ogolnej i Transplantacyjnej AM w Lodzi.
Czarnecki
Paweł
P
Markert
Ryszard
R
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D010431:Pentoxifylline / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D010726:Phosphodiesterase Inhibitors; D010431:Pentoxifylline