title: Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease.
abstract: A clinical trial was undertaken to investigate the efficacy of a single dose of carprofen (CPF) in the treatment of bovine respiratory disease in cattle. Tilmicosin was used as a basal treatment in all animals. Six hours after dosing, body temperature and respiratory rates in animals treated with CPF-tilmicosin had decreased and were significantly lower than in the animals treated with tilmicosin alone (P < 0.05). Over the period of clinical observation, CPF-tilmicosin treatment produced a clinical resolution of the pneumonia similar to treatment with tilmicosin alone. However, it is significant from an animal welfare perspective that over the period of the study after treatment, CPF-tilmicosin therapy produced significantly greater symptomatic improvement than tilmicosin.
authors.affiliation: University of Afyon Kocatepe, Faculty of Veterinary Medicine, Department of Internal Medicine, TR-03200-Afyon, Turkey. elitok1969@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Elitok
authors.forename: O M
authors.initials: OM
authors.lastname: Elitok
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000473:pathology; D007279:Injections, Subcutaneous / Q000662:veterinary; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002227:Carbazoles; D018942:Macrolides; C007005:carprofen; C052319:tilmicosin; D015645:Tylosin