Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence.
This report describes a patient with a gastric biopsy specimen showing histomorphological and immunohistochemical appearances indistinguishable from those usually present in lymphocytic gastritis, a rare condition of unknown aetiology with a distinctive phenotype. The patient had a history of a biopsy confirmed T cell non-Hodgkin lymphoma at two anatomical sites (bladder and stomach), which was subsequently treated. Molecular analysis of the T cell receptor (TCR) gamma chain gene rearrangements showed a distinct monoclonal T cell population in the bladder and gastric biopsies. The same analysis in the lymphocytic gastritis-like biopsy sample showed a monoclonal population with identical base pair size to that identified in the other specimens. This report highlights the importance of TCR gene rearrangement analysis in the diagnosis of unusual gastric inflammation, and the use of capillary electrophoresis based polymerase chain reaction in the follow up of lymphoproliferative disorders.
Nga
M E
ME
Department of Pathology, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074.
Tan
S H
SH
Teh
M
M
Koay
E S C
ES
Chong
S M
SM
Putti
T C
TC
Salto-Tellez
M
M
D015703:Antigens, CD / Q000032:analysis; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000473:pathology*
D015703:Antigens, CD; D011948:Receptors, Antigen, T-Cell