title: Urticarial erythema associated with IgA myeloma.
abstract: We report a case of atypical urticaria associated with IgA multiple myeloma. A 79-year-old man presented with a two-month history of wheal-like erythema, which lasted approximately one week without any response to anti-histamines. Histological examination of a lesion revealed leukocytoclasia as well as perivascular leukocytic infiltration, being consistent with urticarial erythema. Laboratory investigation showed markedly elevated serum IgA concentration and M-protein in serum protein electrophoresis. A bone marrow examination led to a diagnosis of myeloma. An immunofluorescence study failed to detect any IgA deposit in the lesion. However, the wheal-like eruptions disappeared when the IgA myeloma was treated and reappeared when it relapsed. We conclude that this long lasting urticaria was the cutaneous manifestation of IgA myeloma.
authors.affiliation: Department of Dermatology, School of Medicine, Shimane University, Izumo, Japan.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Eishin
authors.initials: E
authors.lastname: Morita
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsuo
authors.forename: Daizo
authors.initials: D
authors.lastname: Ueda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Dekio
mesh_terms: D000368:Aged; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001854:Bone Marrow Cells; D003937:Diagnosis, Differential; D004890:Erythema / Q000209:etiology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology
chemical_list: D007070:Immunoglobulin A