title: Montelukast has no ergogenic effect on cycle ergometry in cold temperature.
abstract: OBJECTIVE
  To examine the effects of a single 10-mg dose of ML on physical performance in EIB- and EIB+ athletes.
  
  
  METHODS
  Twenty-four male college ice hockey players performed two 6-min maximal work accumulation bouts on an electronically braked cycle ergometer in subfreezing conditions (-2.5 +/- 0.4 degrees C) 6-8 h after either ML or placebo (PL) to obtain total work accumulated (kJ); subjects were evaluated for EIB after each exercise trial.
  
  
  RESULTS
  Eight (33%) subjects were identified as EIB+ (23.5 +/- 13.35% fall in FEV1); 16 were EIB- (1.8 +/- 3.03% fall in FEV1). ML provided an approximately 50% protection against postexercise fall in FEV1. No significant differences in kJ were found between PL and ML trials for pooled subjects (95.3 +/- 13.69 and 94.8 +/- 13.27 kJ, respectively), EIB- subjects (99.6 +/- 13.26 and 99.0 +/- 11.81 kJ, respectively), or EIB+ subjects (86.8 +/- 10.67 and 86.5 +/- 12.72 kJ, respectively). Total work accumulated for EIB- subjects was significantly greater than for EIB+ subjects for both PL and ML (P < 0.05).
  
  
  CONCLUSIONS
  A single 10-mg dose of ML had no ergogenic effect for EIB- and EIB+ subjects performing short-duration high-intensity exercise in subfreezing temperature, supporting the use of ML as EIB prophylaxis during international sport competition.
authors.affiliation: Human Performance Laboratory, Keith J. O'Neill Center for Healthy Families, Marywood University, Scranton, PA 18509, USA. rundell@marywood.edu
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Rundell
authors.forename: Barry A
authors.initials: BA
authors.lastname: Spiering
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Baumann
authors.forename: Tina M
authors.initials: TM
authors.lastname: Evans
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D003080:Cold Temperature; D018592:Cross-Over Studies; D003521:Cyclopropanes; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006688:Hockey / Q000502:physiology; D006801:Humans; D008168:Lung / Q000187:drug effects; D008297:Male; D011804:Quinolines / Q000494:pharmacology*; D012129:Respiratory Function Tests; D013440:Sulfides; D013647:Task Performance and Analysis
chemical_list: D000085:Acetates; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; C093875:montelukast