Morning levels of fibrinogen in children with sleep-disordered breathing.
Elevated fibrinogen level is a predictor of cardiovascular disease in adults, and it is associated with sleep-disordered breathing. Levels of fibrinogen in adults are affected by other co-existing cardiovascular risk factors, which are not usually present in children. To investigate the association between fibrinogen and sleep-disordered breathing, a case-control study was carried out in children with and without habitual snoring. All snoring children underwent polysomnography. Morning fibrinogen values in 30 children with snoring and an apnoea-hypopnoea index (AHI) > or =5 episodes x h(-1) (median (interquartile range) 318 mg x dL(-1) (290-374)) were similar to values in 61 children with snoring and an AHI <5 episodes x h(-1) (307 (269-346)). Both groups had higher fibrinogen values than those in 23 controls without snoring (271 mg x dL(-1) (244-294)). There was no correlation between fibrinogen values and AHI, respiratory movement/arousal index or haemoglobin desaturation index. In conclusion, fibrinogen values are higher in children with snoring than in controls, but there is no association between these values and polysomnography indices.
Kaditis
A G
AG
Dept of Paediatrics, University of Thessaly School od Medicine, Larissa University Hospital, PO Box 1425, Larissa 41110, Greece. KADITIA@hotmail.com
Alexopoulos
E I
EI
Kalampouka
E
E
Kostadima
E
E
Angelopoulos
N
N
Germenis
A
A
Zintzaras
E
E
Gourgoulianis
K
K
D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008297:Male; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000378:metabolism*; D013995:Time
D005340:Fibrinogen