One-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from in situ generated azides.
[reaction: see text] 1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields by a convenient one-pot procedure from a variety of readily available aromatic and aliphatic halides without isolation of potentially unstable organic azide intermediates.
Feldman
Alina K
AK
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Colasson
Benoît
B
Fokin
Valery V
VV
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis*; D014753:Vinyl Compounds / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D006846:Hydrocarbons, Halogenated; D014230:Triazoles; D014753:Vinyl Compounds