title: Steroids and sesquiterpenoids from the soft corals Dendronephthya gigantea and Lemnalia cervicorni.
abstract: One new cytotoxic steroid, dendronesterone A (1), two new steroids, dendronesterones B and C (2 and 3), and a known steroid (4) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya gigantea. Two cytotoxic ylangene-type sesquiterpenoids, lemnalol (5) and the new compound cervicol (6), as well as two ylangene-type sesquiterpenoids, isolemnalol (7) (a new compound) and 4-oxo-alpha-ylangene (8), were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia cervicorni. Their structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
authors.affiliation: Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. yihduh@mail.nsysu.edu.tw
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
authors.forename: Ali A H
authors.initials: AA
authors.lastname: El-Gamal
authors.forename: Pei-Ying
authors.initials: PY
authors.lastname: Song
authors.forename: Shang-Kwei
authors.initials: SK
authors.lastname: Wang
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D008811:Mice, Inbred DBA; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D013256:Steroids; C493618:dendronesterone A; C493619:dendronesterone B; C493620:dendronesterone C; C038776:lemnalol