title: Linear accelerator radiosurgery in the treatment of brain metastases.
abstract: OBJECTIVE
  To review a 12-year experience treating metastatic brain disease with linear accelerator-based stereotactic radiosurgery (SRS).
  
  
  METHODS
  We performed a retrospective analysis of all patients treated between 1989 and 2001 with linear accelerator radiosurgery for brain metastases. Patients were followed up both clinically and with imaging studies to document local control, regional control, and survival. Demographic data, dosing parameters, number of lesions, histology, history of whole-brain radiation therapy, and other factors were obtained prospectively. Cox proportional-hazards regression with multivariate and univariate analysis was performed with Stata 8.0 software.
  
  
  RESULTS
  A total of 383 patients received SRS for brain metastases during the study interval. Median survival was 9 months. Patients with tumor-type melanoma or multiple metastatic lesions had decreased survival. Actuarial 1-year local control was 75%. Differences in regional control rates were not statistically significant between patients treated with SRS and whole-brain radiation therapy versus SRS alone.
  
  
  CONCLUSIONS
  Radiosurgery is an effective and safe method for treating selected patients with brain metastases.
authors.affiliation: Department of Neurosurgery, University of Florida, Gainesville, Florida 32610, USA.
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Ulm
authors.forename: William A
authors.initials: WA
authors.lastname: Friedman
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Bova
authors.forename: Patrick
authors.initials: P
authors.lastname: Bradshaw
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amdur
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D012107:Research Design; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome