[Experimental study on anti-pyretic effect of gegen qin lian decoction and its compounds].
OBJECTIVE
To investigate composition principles of Gegen Qin Lian decoction through anti-pyretic experiment.


METHODS
Pharmacological effects of different compounds of Gegen Qin Lian decoction according to six hours temperature response index (TRI6) and average top temperature response height (deltaT) after the decoction was given to feverish animal model by inactived bacteria suspension.


RESULTS
As for reducing six hour temperature response index, Scutellaria baicalensis root was the main effective drug. Pueraria lobata root could enforce the effect while Coptis chinensis rhizome and Glycyrrhiza uralensis root counteracted it. As for reducing average top temperature response height, the Effects of four herbal drugs were the same as for TRI6.


CONCLUSIONS
Of the compounds of Gegen Qin Lian decoction, as to the pharmcological anti-pyretic effects, the best one is the compound of Scutellaria baicalensis and Pueraria lobata roots.
Yu
Lin-Zhong
LZ
Department of Chinese Drugs Pharmacology of First Military Medical University, Guangzhou 510515, China. yulzh@fimmu.com
Wu
Jie-yong
JY
Luo
Jia-Bo
JB
Huang
Xu-Guang
XG
Shao
Hong-xia
HX
Lin
Hui
H
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D039323:Coptis / Q000737:chemistry; D004338:Drug Combinations; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli; D004927:Escherichia coli Infections; D005334:Fever / Q000188:drug therapy / Q000382:microbiology; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D008297:Male; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D031364:Scutellaria baicalensis / Q000737:chemistry
D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal