Dai-kenchu-to raises levels of calcitonin gene-related peptide and substance P in human plasma.
Sensory afferent neurons in the gastrointestinal mucosa regulate neuropeptides [calcitonin gene-related peptide (CGRP), substance P, etc.], which play various physiologic roles and are gastroprotective. To determine whether the pharmacologic effects of Dai-kenchu-to (DKCT) on the gastrointestine are due to changes in gastrointestinal mucosa regulatory peptide levels, we examined the effects of the DKCT on the levels of CGRP-like immunoreactive substances (IS) and substance P-IS in plasma taken from five healthy subjects. A single oral administration of DKCT 7.5 g caused significant increases in plasma CGRP-IS at 40 min, and in substance P-IS levels at 20 and 60 min, compared with a placebo group. The present study may indicate that the pharmacologic action of DKCT is closely related to changes in CGRP- and substance P-IS levels.
Sato
Yuhki
Y
Department of Clinical Pharmacy, Oita University Hospital, Oita, Japan. SYUHKI@med.oita-u.ac.jp
Katagiri
Fumihiko
F
Inoue
Shin
S
Itoh
Hiroki
H
Takeyama
Masaharu
M
D000284:Administration, Oral; D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D008297:Male; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology*; D013373:Substance P / Q000097:blood*; D013997:Time Factors; D032106:Zanthoxylum; D030521:Zingiberaceae
D005765:Gastrointestinal Agents; D010936:Plant Extracts; C121414:dai-kenchu-to; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide