title: Novel C-C bond formation through addition of ammonium ylides to arylaldehydes: a facile approach to beta-aryl-beta-hydroxy alpha-amino acid frameworks.
abstract: Ammonium ylides generated in situ from [small alpha]-diazo esters and amines in the presence of catalytic Rh2(OAc)4, undergo an aldol-type reaction with aldehydes affording highly substituted amino acid frameworks in a convergent, three-component reaction.
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Orangic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Yuanhua
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Chen
authors.forename: Aiqiao
authors.initials: A
authors.lastname: Mi
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis*
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D000644:Quaternary Ammonium Compounds