title: Role of troponin I in active infective endocarditis.
abstract: Infective endocarditis (IE) remains a disease associated with high morbidity and mortality rates. In this pilot study, the role of troponin I in IE was assessed. Myocardial involvement distal to the site of infection in IE has been previously described. Elevated troponin was demonstrated in 11 of 15 patients diagnosed with the condition. Patients diagnosed with staphylococcal endocarditis were more likely to have elevated troponin (3 of 3 patients). Patients with elevated troponin I were not more likely to need valve replacement. Troponin I levels did not predict perivalvular extension. It is hypothesized that elevated troponin I is a reflection of myocardial involvement.
authors.affiliation: Department ofCardiology, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom. richard@watkinr.freeserve.co.uk
authors.forename: Richard W
authors.initials: RW
authors.lastname: Watkin
authors.forename: Sue
authors.initials: S
authors.lastname: Lang
authors.forename: Janet M
authors.initials: JM
authors.lastname: Smith
authors.forename: Thomas S J
authors.initials: TS
authors.lastname: Elliott
authors.forename: William A
authors.initials: WA
authors.lastname: Littler
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000382:microbiology; D002097:C-Reactive Protein / Q000378:metabolism; D016124:Eikenella corrodens; D004697:Endocarditis, Bacterial / Q000378:metabolism* / Q000382:microbiology / Q000503:physiopathology*; D004756:Enterobacteriaceae Infections / Q000378:metabolism* / Q000382:microbiology / Q000503:physiopathology*; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000382:microbiology; D013203:Staphylococcal Infections / Q000378:metabolism* / Q000382:microbiology / Q000503:physiopathology*; D013290:Streptococcal Infections / Q000378:metabolism* / Q000382:microbiology / Q000503:physiopathology*; D019210:Troponin I / Q000378:metabolism / Q000502:physiology*
chemical_list: D019210:Troponin I; D002097:C-Reactive Protein