Viral loads in clinical specimens and SARS manifestations.
A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.
Hung
I F N
IF
Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region, China.
Cheng
V C C
VC
Wu
A K L
AK
Tang
B S F
BS
Chan
K H
KH
Chu
C M
CM
Wong
M M L
MM
Hui
W T
WT
Poon
L L M
LL
Tse
D M W
DM
Chan
K S
KS
Woo
P C Y
PC
Lau
S K P
SK
Peiris
J S M
JS
Yuen
K Y
KY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004196:Disease Outbreaks; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000821:virology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000302:isolation & purification*; D045169:Severe Acute Respiratory Syndrome / Q000097:blood / Q000503:physiopathology* / Q000652:urine / Q000821:virology*; D019562:Viral Load