title: Clinical significance of isolated hippocampal volume asymmetry in childhood epilepsy.
abstract: This study defines the clinical characteristics and evolution of 16 epileptic children with hippocampal asymmetry (HA) without sclerosis on MRI. The association of a positive family history of epilepsy (11/16), low incidence of febrile seizures (2/16), and benign prognosis (seizure control in monotherapy in 11/16, mean follow-up = 4.3 years, range 1 to 10) suggest a different clinical presentation than patients with mesial temporal sclerosis. Genetic studies of these mostly French Canadian families should help confirm the existence of a distinct syndrome.
authors.affiliation: Department of Pediatrics, Neurology Division, Hôpital Sainte-Justine, 3175 Côte Ste-Catherine, Montréal, Québec, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Major
authors.forename: J-C
authors.initials: JC
authors.lastname: Décarie
authors.forename: A
authors.initials: A
authors.lastname: Nadeau
authors.forename: P
authors.initials: P
authors.lastname: Diadori
authors.forename: A
authors.initials: A
authors.lastname: Lortie
authors.forename: D
authors.initials: D
authors.lastname: Nguyen
authors.forename: P
authors.initials: P
authors.lastname: Cossette
authors.forename: L
authors.initials: L
authors.lastname: Carmant
mesh_terms: D000293:Adolescent; D000367:Age Factors; D017668:Age of Onset; D000927:Anticonvulsants / Q000627:therapeutic use; D001284:Atrophy / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D018450:Disease Progression; D004351:Drug Resistance / Q000235:genetics; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D005192:Family Health; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D003294:Seizures, Febrile / Q000453:epidemiology; D014057:Tomography, X-Ray Computed
chemical_list: D000927:Anticonvulsants