Site-specific oxidative cleavage of DNA by metallosalen-DNA conjugates.
Ni-salen-DNA conjugates, prepared by template-directed synthesis, targeted oxidative adduct formation and strand scission at deoxyguanosine sites in complementary DNA strands of Watson-Crick duplexes.
Czlapinski
Jennifer L
JL
Northwestern University, Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
Sheppard
Terry L
TL
D004247:DNA / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013379:Substrate Specificity
D005029:Ethylenediamines; D009942:Organometallic Compounds; D009532:Nickel; D004247:DNA; C011452:disalicylaldehyde ethylenediamine