[Genes and cardiovascular diseases].
In recent years there has been observed a relatively fast progress of explaining genetic mechanisms of development of many cardiovascular system diseases, mainly diseases conditioned by the mutation of single genes. The situation is different when analyzing the dependencies of complex cardiovascular system diseases whose development has many stages depending on exogenous or hereditary factors. The development of those diseases is due to interactions between particular environmental factors, individual differences in response to environmental factors and often complex genetic relations. The complexity of etiopathogenesis and clinical differentiation are the result of superposition of the effects of the action of single genes responsible for the development, predisposing and/or modulating the course. The analysis of genetic causes of cardiovascular system diseases is made on the basis of models and multigene polymorphisms.
Kwiecień
Jakub
J
Wojskowy Instytut Medyczny, Klinika Chorób Wewnetrznych i Kardiologii CSK MON w Warszawie.
Skrobowski
Andrzej
A
Cholewa
Marian
M
D002318:Cardiovascular Diseases / Q000235:genetics* / Q000628:therapy; D005818:Genetic Engineering; D015316:Genetic Therapy; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic