title: Telmisartan - killing two birds with one stone.
abstract: In theory, a drug that inhibits the renin-angiotensin system in order to lower blood pressure and acts as a PPARgamma agonist to increase insulin sensitivity, could be very useful in the treatment of coexisting Type 2 diabetes and hypertension. Telmisartan is an angiotensin Type 1 (AT(1))-receptor antagonist being used in the treatment of hypertension. Recent studies suggest that telmisartan is also a partial PPARgamma agonist. In an animal model of insulin resistance, telmisartan lowered serum levels of glucose, insulin and triglycerides, and body weight. Thus, telmisartan, an AT(1)-receptor antagonist and PPARgamma agonist, represents the prototype of a new approach to treating coexisting diabetes and hypertension, which needs to be evaluated clinically.
authors.affiliation: School of Biomedical Sciences, University of Queensland, QLD 4072, Australia. s_doggrell@yahoo.com
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Doggrell
mesh_terms: D041721:3T3-L1 Cells; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D001565:Benzoates / Q000494:pharmacology / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007333:Insulin Resistance; D000077405:Irbesartan; D051379:Mice; D047495:PPAR gamma / Q000819:agonists*; D051381:Rats; D011924:Rats, Zucker; D000077333:Telmisartan; D013777:Tetrazoles / Q000494:pharmacology
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D001713:Biphenyl Compounds; D047495:PPAR gamma; D013777:Tetrazoles; D000077405:Irbesartan; D000077333:Telmisartan