Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
Of the 206 patients who contracted Severe Acute Respiratory Syndrome (SARS) in Singapore five developed large artery cerebral infarctions. Four patients were critically-ill and three died. Intravenous immunoglobulin was given to three patients. An increased incidence of deep venous thrombosis and pulmonary embolism was also observed among the critically-ill patients. We believe our experience warrants an increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombotic tendency, is contemplated.
Umapathi
T
T
Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433. umapathi_thirugnanam@nni.com.sg
Kor
Ai Ching
AC
Venketasubramanian
N
N
Lim
C C Tchoyoson
CC
Pang
Boon Chuan
BC
Yeo
Tseng Tsai
TT
Lee
Cheng Chuan
CC
Lim
Poh Lian
PL
Ponnudurai
Kuperan
K
Chuah
Khoon Leong
KL
Tan
Puay Hoon
PH
Tai
Dessmon Yeng Huoa
DY
Ang
Sze Peng Brenda
SP
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D045169:Severe Acute Respiratory Syndrome / Q000150:complications* / Q000473:pathology / Q000628:therapy; D020521:Stroke / Q000209:etiology* / Q000473:pathology; D015898:Tomography Scanners, X-Ray Computed; D014715:Vertebrobasilar Insufficiency / Q000209:etiology / Q000473:pathology / Q000628:therapy
D016756:Immunoglobulins, Intravenous