Laschiatrion, a new antifungal agent from a Favolaschia species (Basidiomycetes) active against human pathogens.
Laschiatrion (1), a new antifungal antibiotic, was isolated from fermentations of Favolaschia sp. 87129. (1) exhibits broad in vitro activity against several human pathogens while no antibacterial and cytotoxic activities could be detected. The structure was elucidated by spectroscopic techniques. As to our knowledge laschiatrion possesses a new steroid skeleton.
Anke
T
T
Institute of Biotechnology and Drug Research IBWF e. V., 67663 Kaiserslautern, Germany. timm.anke@ibwf.uni-kl.de
Werle
A
A
Kappe
R
R
Sterner
O
O
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006801:Humans; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D013256:Steroids; C493111:laschiatrion