Chelation-assisted hydrative dimerization of 1-alkyne forming alpha,beta-enones by an Rh(I) catalyst.
The intermolecular hydrative dimerization of 1-alkyne was developed through the chelation-assisted catalytic system with Rh(I)/2-amino-3-picoline. This novel transformation afforded branched and linear alpha,beta-enones directly from two 1-alkyne molecules and H2O. The results demonstrate that a branch/linear ratio can be controlled by the alkyl substituent of 1-alkyne.
Park
Young Jun
YJ
Department of Chemistry and Center for Bioactive Molecular Hybrid (CBMH), Yonsei University, Seoul 120-749, Korea.
Kwon
Bong-Il
BI
Ahn
Jeong-Ae
JA
Lee
Hyuk
H
Jun
Chul-Ho
CH