Successful treatment of pulmonary mucormycosis in an allogenic bone-marrow transplant recipient with combined medical and surgical therapy.
Mucormycosis is a rare, but severe, complication in allogenic bone-marrow recipients with a mortality rate of about 80%. Moreover, its incidence appears to have increased within the last decade. We report a case of pulmonary and nasal mucormycosis in a 55-y-old patient, which occurred 1 y after BMT. Treatment combining 4 months of amphotericin B, early surgical resection of infected tissue and discontinuation of immunosuppressive treatment allowed the cure of this mould infection.
Pavie
Juliette
J
Service des Maladies Infectieuses et Tropicales, Paris, France.
Lafaurie
Matthieu
M
Lacroix
Claire
C
Marie Zagdanski
Anne
A
Debrosse
Denis
D
Socié
Gérard
G
Derouin
Francis
F
Gluckman
Eliane
E
Michel Molina
Jean
J
D000666:Amphotericin B / Q000008:administration & dosage; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000628:therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014184:Transplantation, Homologous / Q000009:adverse effects; D016896:Treatment Outcome
D000666:Amphotericin B