Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions.
The inhibitors of oxidative phosphorylation induced fragmentation of mitochondria without any signs of apoptosis in CV-1 and HeLa cells. Prolonged treatment with the uncouplers (alone or in combination with the inhibitors of respiration) caused perinuclear clusterization of mitochondria, followed by their selective elimination. The fraction of mitochondria-depleted cells remained viable.
Lyamzaev
K G
KG
A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119899 Moscow, Russia.
Pletjushkina
O Y
OY
Saprunova
V B
VB
Bakeeva
L E
LE
Chernyak
B V
BV
Skulachev
V P
VP
D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*
D011725:Pyridines; C100213:piericidin A