New cellular and molecular approaches for the treatment of cardiac disease.
Similar to the kidney in uremia, end-stage cardiac failure is an outcome common to many disparate disease processes including hypertension, various inflammatory pathologies, as well as ischemic loss of tissue. In regard to the heart, cellular and molecular mechanisms responsible for heart failure have been investigated with renewed intensity over the past several years with newer techniques of molecular genetics, genomic analysis, and cell biology. Although this article reviews some recent advances made in our understanding of molecular and cellular events in the heart leading to heart failure and explores possible new targets for therapeutics, the main point is to stress the importance of investigative interactions between organ physiologists and molecular and cellular biologists. These interactions between organ physiologists and molecular geneticists is stressed and supported as a mechanism for rapid advancement for both understanding the underlying pathophysiology of human disease and the development of therapeutic strategies.
Kedes
Laurence
L
Institute of Genetic Medicine, Keck School of Medicine, Los Angeles, CA 90033, USA. kedes@usc.edu
Kloner
Robert
R
Kong
Kimi
K
Poizat
Coralie
C
Simkhovich
Boris
B
Iso
Tatsuya
T
Hamamori
Yasuo
Y
D035843:Biomedical Research; D002319:Cardiovascular System / Q000196:embryology; D002454:Cell Differentiation; D015316:Genetic Therapy / Q000379:methods; D006331:Heart Diseases / Q000628:therapy*; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology; D018919:Neovascularization, Physiologic