title: [Interstitial pneumonia during treatment with thalidomide in a patient with multiple myeloma].
abstract: A 66-year-old man was referred to our hospital for the treatment of refractory multiple myeloma with thalidomide. He had a history of an interstitial pneumonia of unknown etiology two months before admission. Eight days after starting 200 mg/ day of thalidomide, he developed dyspnea and fever, followed by a macropapular rash in the trunk. The dyspnea got worse and a CT scan revealed interstitial pneumonia 16 days after the treatment. He required mechanical ventilatory support. Bronchoalveolar lavage fluid revealed eosinophilia, suggesting a thalidomide-induced interstitial pneumonia. Thalidomide was discontinued and methylprednisolone (1000 mg/d x 3 days) was started, and the pneumonia and rash markedly improved within six days. After that the patient contracted MRSA pneumonia and died of MRSA septicemia.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Keio University School of Medicine.
authors.forename: Toyotaka
authors.initials: T
authors.lastname: Iguchi
authors.forename: Mariyo
authors.initials: M
authors.lastname: Sakoda
authors.forename: Chien-kang
authors.initials: CK
authors.lastname: Chen
authors.forename: Kenji
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hattori
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Okamoto
mesh_terms: D000368:Aged; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy*; D013792:Thalidomide / Q000009:adverse effects*
chemical_list: D013792:Thalidomide