title: A possible case of Werner syndrome presenting with multiple cancers.
abstract: The treatment of a man with six metachronous primary cancers is described. The primary lesions were in the soft palate, both edges of the tongue, the hard palate, the esophagus, and the right ureter. Pathologically, all of the first five tumors in the head and neck and esophagus were proven to be squamous cell carcinoma with various grades of differentiation, and the last one was transitional cell carcinoma. The cancers were found in the early clinical stage, and were completely controlled one by one except for the ureteral tumor under treatment. His characteristic medical history and physical findings, i.e. bilateral cataracts, short stature, baldness, diabetes mellitus, high-pitched voice, and multiple malignancies, met the clinical criteria for possible Werner syndrome, a genetic premature aging disorder, though the possibility of phenocopy of this syndrome has not been ruled out. We have followed him carefully because he might be vulnerable to malignant tumor formation.
authors.affiliation: Department of Otolaryngology and Head & Neck Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. h-iguchi@med.osaka-cu.ac.jp
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Iguchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takayama
authors.forename: Makoto
authors.initials: M
authors.lastname: Kusuki
authors.forename: Kishiko
authors.initials: K
authors.lastname: Sunami
authors.forename: Aki
authors.initials: A
authors.lastname: Nakamura
authors.forename: Hideo
authors.initials: H
authors.lastname: Yamane
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Masaichi
authors.initials: M
authors.lastname: Ohira
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000368:Aged; D001827:Body Height; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000628:therapy; D002295:Carcinoma, Transitional Cell / Q000209:etiology / Q000628:therapy; D002386:Cataract / Q000209:etiology; D004938:Esophageal Neoplasms / Q000209:etiology / Q000628:therapy; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000209:etiology* / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000628:therapy; D012871:Skin Diseases / Q000209:etiology; D014516:Ureteral Neoplasms / Q000209:etiology / Q000628:therapy; D014898:Werner Syndrome / Q000150:complications* / Q000175:diagnosis*