Within you, without you: HIV-1 Rev and RNA export.
Nucleo-cytoplasmic transport of RNA is one of many cellular pathways whose illumination has progressed hand in hand with understanding of retroviral mechanisms. A recent paper in Cell reports the involvement of an RNA helicase in the pathway by which HIV exports partially spliced and unspliced RNA out of the nucleus. This suggests the ubiquity of RNA helicases in RNA export from the nucleus, and has novel mechanistic implications.
Dayton
Andrew I
AI
Center for Biologics Evaluation and Research, Food and Drug Administration, USA. dayton@cber.fda.gov
D019380:Anti-HIV Agents; D015694:Gene Products, rev / Q000378:metabolism*; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics*; D020365:RNA Helicases / Q000378:metabolism; D012326:RNA Splicing; D012367:RNA, Viral / Q000378:metabolism*; D054321:rev Gene Products, Human Immunodeficiency Virus
D019380:Anti-HIV Agents; D015694:Gene Products, rev; D012367:RNA, Viral; D054321:rev Gene Products, Human Immunodeficiency Virus; D020365:RNA Helicases