title: Production by Escherichia coli isolates of siderophore and other virulence factors and their pathogenic role in a cutaneous infection model.
abstract: Escherichia coli isolates from urinary tract infections (UTIs) (n = 124), extra-urinary sites (n = 37) and normal faecal samples (n = 51) were examined for the presence of virulence factors, including siderophores (aerobactin and enterobactin). The proportion of aerobactin producers was significantly higher in UTI (69.4%; p 0.001) and extra-urinary samples (70.3%; p 0.007) than in controls (41.2%), while the proportion of enterobactin producers was significantly lower in the UTI samples than in the controls (p 0.027). In a cutaneous infection model, aerobactin-positive E. coli showed more growth than non-aerobactin and non-enterobactin isolates, even when other virulence factors were identical.
authors.affiliation: Pamukkale University, Medical School, Department of Microbiology, Denizli, Turkey. mdemir@pamukkale.edu.tr
authors.forename: M
authors.initials: M
authors.lastname: Demir
authors.forename: I
authors.initials: I
authors.lastname: Kaleli
mesh_terms: D000818:Animals; D004758:Enterobactin / Q000378:metabolism; D004926:Escherichia coli / Q000254:growth & development / Q000472:pathogenicity*; D006801:Humans; D006877:Hydroxamic Acids / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D017262:Siderophores / Q000096:biosynthesis*; D017192:Skin Diseases, Bacterial / Q000382:microbiology / Q000503:physiopathology*; D014552:Urinary Tract Infections / Q000382:microbiology / Q000503:physiopathology; D037521:Virulence Factors / Q000096:biosynthesis*
chemical_list: D006877:Hydroxamic Acids; D017262:Siderophores; D037521:Virulence Factors; C031819:aerobactin; D004758:Enterobactin