title: Phytoadaptogen for preventive oncology: immunobiological criteria of composition.
abstract: A system of in vitro immunobiological tests is developed for screening of phytopreparations intended for the use as immunomodulators in oncology. Proliferative activity of human tumor cells decreased after treatment with complex phytoadaptogen. The immunomodulatory effect of this phytoadaptogen on immunocompetent cells of cancer patients and its nonspecific interferonogenic effect were detected. The composition of adaptogenic complex for preventive oncology is determined.
authors.affiliation: N N Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow. bolga@edito.umos.ru
authors.forename: O A
authors.initials: OA
authors.lastname: Bocharova
authors.forename: M A
authors.initials: MA
authors.lastname: Lyzhenkova
authors.forename: M V
authors.initials: MV
authors.lastname: Mezentseva
authors.forename: V V
authors.initials: VV
authors.lastname: Semernina
authors.forename: V A
authors.initials: VA
authors.lastname: Knyazhev
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000943:Antigens, Differentiation / Q000276:immunology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007372:Interferons / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009367:Neoplasm Staging; D009369:Neoplasms / Q000517:prevention & control*; D010051:Ovarian Neoplasms / Q000276:immunology; D010936:Plant Extracts / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000276:Adjuvants, Immunologic; D000943:Antigens, Differentiation; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D007372:Interferons