title: Squamous cell carcinoma of the skin.
abstract: After studying this article, the participant should be able to: 1. Identify the subtypes of squamous cell carcinoma of the skin. 2. Identify factors that affect recurrence and/or metastasis. 3. Develop a surgical management plan for treating high-risk squamous cell carcinoma of the skin. In treating squamous cell carcinoma of the skin, a key concept in proper management is understanding why certain tumors are more prone to both recurrence and metastasis. When developing a surgical management plan, an understanding of "high risk" is essential. This article concentrates on identifying those tumor subtypes and factors that may serve as predictors of high-risk status as well as on providing management suggestions.
authors.affiliation: Division of Plastic and Reconstructive Surgery at Scripps Clinic and at the University of California San Diego, La Jolla, Calif, USA. rrudolph@scrippsclinic.com
authors.forename: Ross
authors.initials: R
authors.lastname: Rudolph
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Zelac
mesh_terms: D001913:Bowen's Disease / Q000473:pathology; D018196:Carcinoma, Adenosquamous / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery; D018289:Carcinoma, Verrucous / Q000473:pathology; D002454:Cell Differentiation; D002921:Cicatrix / Q000150:complications; D017679:Cryotherapy; D003475:Curettage; D004599:Electric Stimulation Therapy; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D007636:Keratoacanthoma / Q000175:diagnosis / Q000473:pathology; D008297:Male; D015580:Mohs Surgery; D009361:Neoplasm Invasiveness; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology; D012878:Skin Neoplasms / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery; D014466:Ultraviolet Rays / Q000009:adverse effects