title: Notable coordination effects of 2-pyridinesulfonamides leading to efficient aziridination and selective aziridine ring opening.
abstract: [reaction: see text] We have developed, on the basis of a chelation-strategy, an efficient copper-catalyzed aziridination protocol with the use of 5-methyl-2-pyridinesulfonamide and PhI(OAc)(2). The reaction proceeds smoothly under mild conditions to give aziridines in moderate to good yields in the absence of external ligands or bases. The coordination-assisted approach offers the additional benefits that efficient deprotection of the N-substituent and selective aziridine ring-opening are effectively achieved.
authors.affiliation: Center for Molecular Design and Synthesis, Department of Chemistry and School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology (KAIST), Daejon 305-701, Republic of Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Han
authors.forename: Imhyuck
authors.initials: I
authors.lastname: Bae
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Yoo
authors.forename: Junseong
authors.initials: J
authors.lastname: Lee
authors.forename: Youngkyu
authors.initials: Y
authors.lastname: Do
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang