Protective effect of phenyl-t-butylnitrone in rats with focal cerebral ischemia.
Phenyl-t-butylnitrone produces a potent neuroprotective effect in rats with focal cerebral ischemia modeled by distal occlusion of the middle cerebral artery. The infarction area markedly decreased after treatment with phenyl-t-butylnitrone. The content of phenyl-t-butylnitrone in the brain, liver, and kidneys was measured by the method of electron paramagnetic resonance.
Povarova
O V
OV
Department of Pharmacology, Faculty of Fundamental Medicine, M V Lomonosov Moscow State University, Moscow. povarova@fbm.msu.ru
Timoshin
A A
AA
Medvedev
O S
OS
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003497:Cyclic N-Oxides; D004195:Disease Models, Animal; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D007668:Kidney / Q000737:chemistry / Q000187:drug effects; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D018696:Neuroprotective Agents / Q000032:analysis / Q000494:pharmacology*; D009589:Nitrogen Oxides / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013113:Spin Labels
D003497:Cyclic N-Oxides; D005609:Free Radicals; D018696:Neuroprotective Agents; D009589:Nitrogen Oxides; D013113:Spin Labels; C029217:phenyl-N-tert-butylnitrone