[Sickle cell disease and infection].
OBJECTIVE
To discuss the high prevalence of sickle cell disease in our environment and the increased morbidity and mortality as a result of infection associated with this condition.


METHODS
Review of MEDLINE from 1986 to 2003. We found around 600 references about the subject. Thirty-five journal articles were reviewed, in addition to chapters in two text books.


RESULTS
We discuss general information concerning sickle cell disease as well as a few topics about the most frequently observed infections in these patients. Drug prophylaxis and immunizations are also covered.


CONCLUSIONS
This review hopes to provide the pediatric community with information concerning the association between sickle cell disease and infections, so as to minimize the occurrence of complications.
Di Nuzzo
Dayana V P
DV
Departamento de Pediatria, Universidade Federal da Bahia (UFBA), Salvador, BA. bluemare@ig.com.br
Fonseca
Silvana F
SF
D000755:Anemia, Sickle Cell / Q000150:complications* / Q000188:drug therapy / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000188:drug therapy / Q000209:etiology*; D008297:Male