Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.
The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.
Motoyoshi
Hajime
H
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Horigome
Masato
M
Ishigami
Ken
K
Yoshida
Tatsuhiko
T
Horinouchi
Sueharu
S
Yoshida
Minoru
M
Watanabe
Hidenori
H
Kitahara
Takeshi
T
D001710:Biotin / Q000737:chemistry*; D019921:Biotinylation; D002453:Cell Cycle / Q000187:drug effects*; D011714:Pyrans / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013141:Spiro Compounds / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
C104486:FR 901464; D011714:Pyrans; D013141:Spiro Compounds; D001710:Biotin