[The role of HMG-CoA reductase inhibitors in regulation of the inflammatory processes].
Statins operate through inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a key enzyme which regulates intracellular cholesterol synthesis. Their so-called pleiotropic effects incorporate alterations of endothelial function, inflammation, coagulation and plaque stability. This review will focus on statins regulation role in inflammation.
Cecha
Jószef
J
Oddziału Klinicznego Chorób Wewnetrznych w Bytomiu.
Drabek
Grzegorz
G
Błazelonis
Adam
A
Romanowski
Wojciech
W
Zubelewicz-Szkodzińska
Barbara
B
D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000096:biosynthesis; D018384:Oxidative Stress / Q000187:drug effects
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol; D019001:Nitric Oxide Synthase