title: [Analysis of p53 gene mutation in salivary adenoid cystic carcinoma.].
abstract: OBJECTIVE
  The purpose of this study was to investigate the occurrence of p53 gene mutation in salivary adenoid cystic carcinoma, the correlation between the gene and prognostic significance.
  
  
  METHODS
  A series of salivary adenoid cystic carcinoma were studied by polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) analysis to detect p53 mutation, respectively.
  
  
  RESULTS
  The result showed that p53 gene mutations in exon 5-8 were detected in 65.8% (25/38) of the salivary adenoid cystic carcinoma. The p53 gene mutation was related to tumor distant metastasis and tumor recurrence (P<0.05) but not related to pathological types, clinical stages (P>0.05).There was a significant correlation between p53 gene mutation and postoperative survival .
  
  
  CONCLUSIONS
  It is suggested that p53 gene mutations were very common in salivary adenoid cystic carcinoma, and might be useful in screening progress and evaluating prognosis of patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong Province, China. ds63zhang@hotmail.com.
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Zhang
authors.forename: Cui-rong
authors.initials: CR
authors.lastname: Bian
authors.forename: Pei-yu
authors.initials: PY
authors.lastname: Wang
authors.forename: Xi-lan
authors.initials: XL
authors.lastname: Yuan
authors.forename: Jia-yao
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis