[Study rat nephrotoxicity of Longdan Xiegan Tang].
OBJECTIVE
To investigate the nephrotoxocity of Longdan Xiegan Tang in rats, and to test its safety.


METHODS
Sprague-Dauley rats were given Longdan Xiegan Tang 4.5 mL x (100 mg)(-1) Bid for thirty days, and the control group was given NS. MTP, BUN, Cr, MDA, MTP/Ucr and SOD were measured on 1st, 2nd, 3rd, 4th week. The kidney tissues were viewed with light microscopy and electron microscope.


RESULTS
MTP and MTP/Ucr were obviously higher than controls ( P < 0.01), and the other index had no difference (P > 0.05). No remarkable structural change could been seen with light microscopy, but with electron microscope we could find that the basal membranes were thickened and some of foot process were infused.


CONCLUSIONS
Longdan Xiegan Tang will result in injury of kidney function.
Fang
Qing
Q
Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China. pharmacy302@sohu.com
Zhan
Xiao-Ping
XP
Mo
Jian-Ling
JL
Sun
Mei
M
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D030012:Gentiana / Q000737:chemistry; D007668:Kidney / Q000648:ultrastructure*; D007672:Kidney Cortex / Q000378:metabolism; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D003404:Creatinine; D013482:Superoxide Dismutase