Synthesis of the trisaccharide repeating unit of the atypical O-antigen polysaccharide from Danish Helicobacter pylori strains employing the 2'-carboxybenzyl glycoside.
[reaction: see text] Synthesis of the unique trisaccharide repeating unit of the O-polysaccharide of the lipopolysaccharide from Danish Helicobacter pylori strains has been accomplished. Key steps include the coupling of three monosaccharide moieties by glycosylations employing the 2'-carboxybenzyl glycoside method. Also presented is a method for the synthesis of the novel branched sugar, 3-C-methyl-D-mannose, which is one of three monosaccharide components.
Kwon
Yong Tae
YT
Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Lee
Yong Joo
YJ
Lee
Kyunghoon
K
Kim
Kwan Soo
KS
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000737:chemistry*; D006031:Glycosylation; D016480:Helicobacter pylori / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry / Q000378:metabolism; D008766:Methylmannosides / Q000737:chemistry / Q000378:metabolism; D019081:O Antigens / Q000737:chemistry* / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry*; D014312:Trisaccharides / Q000138:chemical synthesis*
D006027:Glycosides; D008070:Lipopolysaccharides; D008766:Methylmannosides; D019081:O Antigens; D011134:Polysaccharides; D014312:Trisaccharides