title: Long-term histopathologic evaluation of inferior vena cava after modified Greenfield filter implantation. Experimental study in sheep.
abstract: OBJECTIVE
  The authors assess a modified Greenfield filter (GF) for the long-term patency, filter tilting and histopathologic alterations of the inferior vena cava (IVC).
  
  
  METHODS
  Adult sheep (n=7) underwent modified GF placement in the IVC. Cavograms were obtained every 3 months and pulmonary angiography at 12 months. Histopathologic and scanning electron microscopy (SEM) analyses were performed on the IVC explanted at 12 months.
  
  
  RESULTS
  Cavograms showed that all IVC were patent at the end of the study. Filter tilting occurred in 2/7 animals and extrusion of struts was not observed. Macroscopic examination at explantation showed minimal venous wall thickening. Microscopic examination showed minimal IVC fibrosis and intimal hyperplasia. SEM showed endothelium on the IVC surface at the filter implantation site and a presumed endothelial layer covering partially or totally the struts. The interface filter-IVC was covered by deposits of leucocytes and platelets. No signs of pulmonary embolism were found in all pulmonary angiograms of both groups.
  
  
  CONCLUSIONS
  The modified filter presented good biocompatibility, stability and absence of thrombogenicity at 12 months. It presented low tendency to tilting and extrusion of struts. The long-term histopathologic alterations in vena caval wall were minimal and the appearance of the studied filters in the IVC was similar to stents placed in the arterial system.
authors.affiliation: Department of Surgery and Orthopedics, Botucatu School of Medicine, Botucatu, São Paulo, Brazil.
authors.forename: W B
authors.initials: WB
authors.lastname: Yoshida
authors.forename: J
authors.initials: J
authors.lastname: Sequera
authors.forename: F H
authors.initials: FH
authors.lastname: De Abreu Maffei
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D008297:Male; D008855:Microscopy, Electron, Scanning; D011474:Prosthesis Design; D012756:Sheep; D014654:Vascular Patency; D016306:Vena Cava Filters; D014682:Vena Cava, Inferior / Q000473:pathology*
chemical_list: D001672:Biocompatible Materials