Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.
Folklore reports from Afghanistan prior to the wars described the use of aqueous root extracts of Cichorium intybus (L.) as a light-sensitive plant remedy for malaria. Preparative isolation and bioassay against HB3 clone of strain Honduras-1 of Plasmodium falciparum identified the previously known light-sensitive sesquiterpene lactones Lactucin and Lactucopicrin to be antimalarial compounds.
Bischoff
Theodore A
TA
Department of Pharmacy, Massachusetts General Hospital, Boston, MA 02114, USA. Bischoff.Theodore@MGH.Harvard.edu
Kelley
Charles J
CJ
Karchesy
Yvette
Y
Laurantos
Maria
M
Nguyen-Dinh
Phuc
P
Arefi
Abdul Ghafoor
AG
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D018651:Cichorium intybus; D004305:Dose-Response Relationship, Drug; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000502:physiology; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000962:Antimalarials; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes