title: Histology impacts the outcome of peripheral T-cell lymphomas after high dose chemotherapy and stem cell transplant.
abstract: The role of high dose chemotherapy (HDC) and stem cell transplant (SCT) in peripheral T-cell lymphoma (PTCL) was studied in 28 patients, from 1988 to 2002. The aim was to determine if subsets recognized by the REAL/WHO classification have different prognoses. Outcome was compared to 86 patients with diffuse large B-cell lymphoma (DLBCL) transplanted during 1986-2000. The 3-year overall survival (OS) and event free survival (EFS) were 69% and 50%. Patients with anaplastic large cell lymphoma (ALCL) had a better 3-year OS compared to those with non-ALCL histology (86% vs. 47%, P=0.0122). Anaplastic lymphoma kinase (ALK)- positive ALCL patients had a superior EFS compared to ALK-negative ALCL (100% vs. 0; P=0.0228). Patients with cutaneous ALCL (ALK-negative) relapsed, but had an indolent course after SCT. Low International Prognostic Index score at relapse predicted for a better 3-year OS (85% vs. 34%, P=0.0238). When compared to DLBCL, patients with ALCL had a superior OS (86% vs. 36%, P=0.0034) and patients with non-ALCL had a comparable OS. ALCL histology confers better survival compared to non-ALCL and DLBCL histologies. ALK-positive ALCL is associated with the best EFS after relapse with HDC and SCT. The timing of SCT for non-ALCL histology remains to be determined.
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Vanderbilt University Medical Center, 2665 TVC, Nashville, TN 37232-5505. madan.jagasia@vanderbilt.edu
authors.forename: Madan
authors.initials: M
authors.lastname: Jagasia
authors.forename: David
authors.initials: D
authors.lastname: Morgan
authors.forename: Stacey
authors.initials: S
authors.lastname: Goodman
authors.forename: Katherine
authors.initials: K
authors.lastname: Hamilton
authors.forename: Marsha
authors.initials: M
authors.lastname: Kinney
authors.forename: Yu
authors.initials: Y
authors.lastname: Shyr
authors.forename: Richard
authors.initials: R
authors.lastname: Stein
authors.forename: John
authors.initials: J
authors.lastname: Zic
authors.forename: John
authors.initials: J
authors.lastname: Greer
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000628:therapy*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000628:therapy; D016411:Lymphoma, T-Cell, Peripheral / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis; D020794:Receptor Protein-Tyrosine Kinases; D012008:Recurrence; D033581:Stem Cell Transplantation / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases