title: Clinical and pathological features of dilated cardiomyopathy in Holstein-Friesian cattle.
abstract: Dilated cardiomyopathy is a primary disease of the heart muscle that has been reported in Holstein-Friesian cattle worldwide in the past 20 years. Nine cases of the condition were compared in terms of their clinical and pathological characteristics with nine unaffected animals matched for age, sex and breed. Their clinical signs included right-sided heart failure with severe subcutaneous oedema, ascites and/or hydrothorax and distended jugular veins. There were no characteristic biochemical or haematological changes. Postmortem, the affected hearts were enlarged with all the chambers dilated and walls of variable thickness. In most cases the kidneys were pale with a pitted surface. Histologically there was marked perimysial and endomysial fibrosis, extensive loss of cardiomyocytes by coagulative or colliquative necrosis, increased variation in the cross-sectional area of the myocardial fibres, and multifocal disarray and vacuolation of myocytes. Scanning electron microscopy showed that in all cases there was a mild myocardial inflammatory infiltrate, either diffuse or multifocal, which was identified by immunohistochemical labelling as T cells.
authors.affiliation: Department of Veterinary Pathology, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow G61 1QH.
authors.forename: P
authors.initials: P
authors.lastname: Nart
authors.forename: H
authors.initials: H
authors.lastname: Thompson
authors.forename: D C
authors.initials: DC
authors.lastname: Barrett
authors.forename: S C
authors.initials: SC
authors.lastname: Armstrong
authors.forename: A R
authors.initials: AR
authors.lastname: McPhaden
mesh_terms: D000367:Age Factors; D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D005355:Fibrosis / Q000473:pathology / Q000662:veterinary; D006321:Heart; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D008855:Microscopy, Electron, Scanning / Q000662:veterinary; D009206:Myocardium / Q000473:pathology* / Q000648:ultrastructure; D032383:Myocytes, Cardiac / Q000648:ultrastructure; D010375:Pedigree; D012737:Sex Factors