Activation by malaria antigens renders mononuclear cells susceptible to HIV infection and re-activates replication of endogenous HIV in cells from HIV-infected adults.
We have tested the hypothesis that activation of T cells by exposure to malaria antigens facilitates both de novo HIV infection and viral reactivation and replication. PBMC from malaria-naive HIV-uninfected European donors could be productively infected with HIV following in vitro stimulation with a lysate of Plasmodium falciparum schizonts and PBMC from malaria-naive and malaria-exposed (semi-immune) HIV-positive adults were induced to produce higher levels of virus after stimulation with the same malaria extract. These findings suggest that effective malaria control measures might con-tribute to reducing the spread of HIV and extending the life span of HIV-infected individuals living in malaria endemic areas.
Froebel
K
K
Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, EH9 3JT, UK.
Howard
W
W
Schafer
J R
JR
Howie
F
F
Whitworth
J
J
Kaleebu
P
P
Brown
A L
AL
Riley
E
E
D000328:Adult; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology; D014779:Virus Replication / Q000276:immunology
D000953:Antigens, Protozoan; D016655:HIV Core Protein p24; D007371:Interferon-gamma