The T-cell response to haptenated insulins. II. The antibody response.
As described in an accompanying paper, trinitrophenyl (TNP) modification of pork insulin (PI) at the A1 glycine position allows this molecule to stimulate a proliferative response in H-2b (B10) mice. We now show that this antigen stimulates low IgG responses in the same strain of mice. Our results show that T-cell help and proliferation may therefore be regulated independently.
Flory
M
M
Tumour Immunology Unit, Department of Biology (Medawar Building), University College London, London, UK.
Wallace
G R
GR
Oettel
K
K
Chain
B M
BM
D019264:Adoptive Transfer / Q000379:methods; D000818:Animals; D000906:Antibodies / Q000097:blood / Q000276:immunology; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D002417:Cattle; D049109:Cell Proliferation; D007328:Insulin / Q000276:immunology / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D007328:Insulin