The scope of receptor editing and its association with autoimmunity.
Random assembly of antibody variable (V), diversity (D) and joining (J) gene segments creates a vast repertoire of antigen receptors, including autoreactive ones. Three ways that are known to reduce autoreactivity in the B-cell compartment include clonal deletion, functional inactivation and receptor editing, a mechanism involving a change in antigen receptor specificity through continued V(D)J recombination. New data suggest that editing can efficiently eliminate autoreactivity, yet, in an autoimmune context, secondary antibody gene rearrangements might also contribute to autoimmunity.
Verkoczy
Laurent K
LK
Department of Immunology, The Scripps Research Institute, Mail Drop IMM-29, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Mårtensson
Annica S
AS
Nemazee
David
D
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D015551:Autoimmunity / Q000235:genetics / Q000276:immunology*; D015322:Gene Rearrangement, B-Lymphocyte / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000276:immunology*
D011947:Receptors, Antigen, B-Cell