title: Lupus panniculitis with combined features of dermatomyositis resulting in severe lipoatrophy.
abstract: An 11-year-old girl presented with a one-year history of multiple, hard, slightly painful subcutaneous nodules on her right cheek, upper arms, and buttock. Histology of a skin biopsy specimen showed a lobular panniculitis. Laboratory studies revealed positive ANA, anti-double strand DNA, and elevated muscle enzymes. She was diagnosed as having lupus panniculitis. During hydroxychloroquine treatment, erythema over knuckle joints developed. These unusual clinical and laboratory findings of panniculitis associated connective tissue diseases made it difficult to make a precise diagnosis. We report this unusual case of lupus panniculitis with combined features of dermatomyositis resulting in severe lipoatrophy.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jong Yeop
authors.initials: JY
authors.lastname: Yoo
authors.forename: Seong Jin
authors.initials: SJ
authors.lastname: Jo
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Cho
mesh_terms: D001707:Biopsy, Needle; D002648:Child; D003882:Dermatomyositis / Q000150:complications* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007150:Immunohistochemistry; D008060:Lipodystrophy / Q000150:complications* / Q000473:pathology*; D015435:Panniculitis, Lupus Erythematosus / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D006886:Hydroxychloroquine