title: Salmon caviar-induced anaphylactic shock.
abstract: Foods, particularly shellfish and nuts, are commonly implicated as causes of anaphylaxis. Salmon caviar, to our knowledge, is an exceedingly rare cause of anaphylactic shock. This study describes a patient who experienced anaphylactic shock on her initial ingestion of caviar. Skin testing and inhibition assays using the enzyme-linked immunosorbent assay were performed. On the percutaneous test, the patient had a 7 x 9 mm/15 x 55 mm wheal/ erythema reaction to caviar liquid. Caviar liquid caused 68, 73, and 73% inhibition of immunoglobulin E (IgE) binding at concentrations of 0.01, 0.1, and 1.0 mg/mL in an enzyme-linked immunosorbent assay, respectively. There was no evidence for IgE antibodies that could be demonstrated to bind to the caviar eggs. Despite using both metoprolol and lisinopril, the patient responded promptly to subcutaneous epinephrine. This report indicates that an IgE-mediated response occurred after caviar ingestion. Although she experienced anaphylactic shock, the patient recovered quickly after epinephrine administration despite routine use of a 3-adrenergic blocker and angiotensin-converting enzyme inhibitor.
authors.affiliation: Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Flais
authors.forename: Susan S
authors.initials: SS
authors.lastname: Kim
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Harris
authors.forename: Paul A
authors.initials: PA
authors.lastname: Greenberger
mesh_terms: D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D000818:Animals; D004531:Eggs / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012474:Salmon / Q000276:immunology