[Expression of type I inositol 1,4,5-triphosphate receptor on rat glomerular and afferent arterioles in a model of liver cirrhosis].
OBJECTIVE
To study the expression of type I inositol 1,4,5-triphosphate receptor in rat glomerular and afferent arterioles in a model of liver cirrhosis and study the role of cross-membrane message transduction in the pathogenesis of hepatorenal syndrome.


METHODS
In a rat model of carbontetrachloride liver cirrhosis, the expression of type I inositol 1,4,5-triphosphate receptor (IP3R) on glomerular and afferent arterioles was measured by immunohistochemical method.


RESULTS
In the experimental group, 30 rats were used to make a model of liver cirrhosis. 11 rats survived during the experiment. The expression of type I IP3R on glomerular and afferent arterioles was 4.97+/-1.34 and 4.09+/-1.14 in the liver cirrhosis group, and it was 2.43+/-1.67 and 1.83+/-1.32 in the normal control rats. The differences between these two groups are statistically significant (t = 2.28, P = 0.0458).


CONCLUSIONS
Expression of type I IP3 receptor on rat glomerular and afferent arterioles in a model of liver cirrhosis indicated that the mechanism of cross-membrane message transduction plays a very important role in the pathogenesis of hepatorenal syndrome.
Wang
Jing-yan
JY
Department of Infectious Disease, No 2 Affiliated Hospital of China Medical University, Shenyang 110004, China.
Liu
Hong-yan
HY
Liu
Pei
P
D000818:Animals; D001160:Arterioles / Q000378:metabolism; D015220:Calcium Channels / Q000096:biosynthesis* / Q000235:genetics; D002251:Carbon Tetrachloride; D002252:Carbon Tetrachloride Poisoning; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007668:Kidney / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000098:blood supply* / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis* / Q000235:genetics; D012077:Renal Artery / Q000378:metabolism*
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D002251:Carbon Tetrachloride