Surgery versus sclerotherapy for the treatment of varicose veins.
BACKGROUND
Varicose veins are a relatively common condition and account for around 54,000 in-patient hospital episodes per year. The two most common interventions for varicose veins are surgery and sclerotherapy. However, there is little comparative data regarding their effectiveness.


OBJECTIVE
To identify whether the use of surgery or sclerotherapy should be recommended for the management of primary varicose veins.


METHODS
Thirteen electronic bibliographic databases were searched covering biomedical, science, social science, health economic and grey literature (including current research). In addition, the reference lists of relevant articles were checked and various health services research-related resources were consulted via the internet. These included health economics and HTA organisations, guideline producing agencies, generic research and trials registers, and specialist sites.


METHODS
All studies that were described as randomised controlled trials comparing surgery with sclerotherapy for the treatment of primary varicose veins were identified.


METHODS
Two reviewers independently extracted and summarised data from the eligible studies using a data extraction sheet for consistency. All studies were cross-checked independently by the reviewers.


RESULTS
A total of 2306 references were found from our searches, 61 of which were identified as potential trials comparing surgery and sclerotherapy. However, only nine randomised trials, described in a total of 14 separate papers, fulfilled the inclusion criteria. Fifty trials were excluded and one trial is ongoing and is due for completion in 2004. The trials used a variety of outcome measures and classification systems which made direct comparison between trials difficult. However, the trend was for sclerotherapy to be evaluated as significantly better than surgery at one year; after one year (sclerotherapy resulted in worse outcomes) the benefits with sclerotherapy were less, and by three to five years surgery had better outcomes. The data on cost-effectiveness was not adequately reported.


CONCLUSIONS
There was insufficient evidence to preferentially recommend the use of sclerotherapy or surgery. There needs to be more research that specifically examines both costs and outcomes for surgery and sclerotherapy.
Rigby
K A
KA
Sheffield Vascular Institute, Sheffield Teaching Hospitals NHS Trust, Vickers 16, Sheffield, UK. mark@rigbyka.freeserve.co.uk
Palfreyman
S J
SJ
Beverley
C
C
Michaels
J A
JA
D006801:Humans; D016032:Randomized Controlled Trials as Topic; D015911:Sclerotherapy; D014648:Varicose Veins / Q000601:surgery / Q000628:therapy*