title: Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future.
abstract: Peroxisome proliferator-activated receptor (PPAR)-alpha is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPAR-alpha regulates the expression of genes involved in fatty acid beta-oxidation and is a major regulator of energy homeostasis. Fibrates are PPAR-alpha agonists and have been used to treat dyslipidemia for several decades because of their triglyceride (TG) lowering and high-density lipoprotein cholesterol (HDL-C) elevating effects. More recent research has demonstrated anti-inflammatory and anti-thrombotic actions of PPAR-alpha agonists in the vessel wall as well. Thus, PPAR-alpha agonists decrease the progression of atherosclerosis by modulating metabolic risk factors and by their anti-inflammatory actions on the level of the vascular wall. This is confirmed by several clinical studies, in which fibrates have shown to reduce atherosclerotic plaque formation and the event rate of coronary heart disease (CHD), especially in patients suffering from metabolic syndrome (MS). MS is characterized by a group of metabolic risk factors that include obesity, raised blood pressure, dyslipidemia, insulin resistance or glucose intolerance, and a prothrombotic state, and its incidence in the Western world is rising to epidemic proportions. This review paper will focus on the functions of PPAR-alpha in fatty acid beta-oxidation, lipid metabolism, and vascular inflammation. Furthermore, PPAR-alpha genetics, the clinical use of PPAR-alpha activators and their future perspective will be discussed.
authors.affiliation: Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: van Raalte
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: P Haydn
authors.initials: PH
authors.lastname: Pritchard
authors.forename: Kishor M
authors.initials: KM
authors.lastname: Wasan
mesh_terms: D001161:Arteriosclerosis / Q000503:physiopathology; D002995:Clofibric Acid / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D047493:PPAR alpha / Q000819:agonists / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D011110:Polymorphism, Genetic
chemical_list: D005227:Fatty Acids; D008074:Lipoproteins; D047493:PPAR alpha; D002995:Clofibric Acid