Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.
The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.
Critchley
D R
DR
Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK. drc@le.ac.uk
D000199:Actins / Q000737:chemistry; D000818:Animals; D001665:Binding Sites; D002448:Cell Adhesion; D002465:Cell Movement; D003599:Cytoskeleton / Q000737:chemistry / Q000378:metabolism*; D019281:Dimerization; D000939:Epitopes / Q000737:chemistry; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008024:Ligands; D008954:Models, Biological; D010766:Phosphorylation; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D016608:Talin / Q000737:chemistry*; D016596:Vinculin / Q000737:chemistry*
D000199:Actins; D000939:Epitopes; D016023:Integrins; D008024:Ligands; D016608:Talin; D016596:Vinculin