Cobalt-mediated cyclotrimerisation of bis-alkynes and cyanamides.
CpCo(CO)2-mediated cyclotrimerisation of bis-alkynes and cyanamides provides multisubstituted 2-aminopyridines, including macrocyclic products, such as 22 (50% yield).
Boñaga
Llorente V R
LV
Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Spring House, PA 19477-0776, USA.
Zhang
Han-Cheng
HC
Maryanoff
Bruce E
BE
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D003484:Cyanamide / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D000480:Alkynes; D009942:Organometallic Compounds; D003035:Cobalt; D003484:Cyanamide