title: High-resolution MR imaging of the rat spinal cord in vivo in a wide-bore magnet at 17.6 Tesla.
abstract: The objective was to demonstrate the feasibility and to evaluate the performance of high-resolution in vivo magnetic resonance (MR) imaging of the rat spinal cord in a 17.6-T vertical wide-bore magnet. A probehead consisting of a surface coil that offers enlarged sample volume suitable for rats up to a weight of 220 g was designed. ECG triggered and respiratory-gated gradient echo experiments were performed on a Bruker Avance 750 wide-bore spectrometer for high-resolution imaging. With T*2 values between 5 and 20 ms, good image contrast could be obtained using short echo times, which also minimizes motion artifacts. Anatomy of healthy spinal cords and pathomorphological changes in traumatically injured rat spinal cord in vivo could be visualized with microscopic detail. It was demonstrated that imaging of the rat spinal cord in vivo using a vertical wide-bore high-magnetic-field system is feasible. The potential to obtain high-resolution images in short scan times renders high-field imaging a powerful diagnostic tool.
authors.affiliation: Department of Physics, EP5 (Biophysics), University of Würzburg, Am Hubland, 97074, Würzburg, Germany. behr@physik.uni-wuerzburg.de
authors.forename: V C
authors.initials: VC
authors.lastname: Behr
authors.forename: T
authors.initials: T
authors.lastname: Weber
authors.forename: T
authors.initials: T
authors.lastname: Neuberger
authors.forename: M
authors.initials: M
authors.lastname: Vroemen
authors.forename: N
authors.initials: N
authors.lastname: Weidner
authors.forename: U
authors.initials: U
authors.lastname: Bogdahn
authors.forename: A
authors.initials: A
authors.lastname: Haase
authors.forename: P M
authors.initials: PM
authors.lastname: Jakob
authors.forename: C
authors.initials: C
authors.lastname: Faber
mesh_terms: D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005260:Female; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D008280:Magnetics; D051381:Rats; D011916:Rats, Inbred F344; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013116:Spinal Cord / Q000473:pathology*; D013119:Spinal Cord Injuries / Q000473:pathology*; D013904:Thoracic Vertebrae / Q000473:pathology