title: Site-specific oxidative cleavage of DNA by metallosalen-DNA conjugates.
abstract: Ni-salen-DNA conjugates, prepared by template-directed synthesis, targeted oxidative adduct formation and strand scission at deoxyguanosine sites in complementary DNA strands of Watson-Crick duplexes.
authors.affiliation: Northwestern University, Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Czlapinski
authors.forename: Terry L
authors.initials: TL
authors.lastname: Sheppard
mesh_terms: D004247:DNA / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013379:Substrate Specificity
chemical_list: D005029:Ethylenediamines; D009942:Organometallic Compounds; D009532:Nickel; D004247:DNA; C011452:disalicylaldehyde ethylenediamine