title: Epstein-Barr virus: 40 years on.
abstract: Epstein-Barr virus (EBV) was discovered 40 years ago from examining electron micrographs of cells cultured from Burkitt's lymphoma, a childhood tumour that is common in sub-Saharan Africa, where its unusual geographical distribution - which matches that of holoendemic malaria -indicated a viral aetiology. However, far from showing a restricted distribution, EBV - a gamma-herpesvirus - was found to be widespread in all human populations and to persist in the vast majority of individuals as a lifelong, asymptomatic infection of the B-lymphocyte pool. Despite such ubiquity, the link between EBV and 'endemic' Burkitt's lymphoma proved consistent and became the first of an unexpectedly wide range of associations discovered between this virus and tumours.
authors.affiliation: Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK. l.s.young@bham.ac.uk
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Young
authors.forename: Alan B
authors.initials: AB
authors.lastname: Rickinson
mesh_terms: D000956:Antigens, Viral / Q000235:genetics / Q000502:physiology; D001402:B-Lymphocytes / Q000473:pathology / Q000821:virology; D002051:Burkitt Lymphoma / Q000453:epidemiology / Q000821:virology; D002277:Carcinoma / Q000628:therapy / Q000821:virology*; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D016867:Immunocompromised Host; D007694:Killer Cells, Natural / Q000473:pathology; D008223:Lymphoma / Q000628:therapy / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000821:virology; D016399:Lymphoma, T-Cell / Q000821:virology; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000821:virology; D013274:Stomach Neoplasms / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology; D017735:Virus Latency
chemical_list: D000956:Antigens, Viral; D014764:Viral Proteins