The efficacy of phenytoin in eclampsia.
Although the Eclampsia Trial Collaborative Group reported that magnesium sulphate was more effective in preventing recurrent convulsions in eclampsia than phenytoin, confirmatory evidence that phenytoin is not useful as a prophylactic anticonvulsant agent in eclampsia is necessary. This prospective descriptive study enrolled 68 women with eclampsia. Recurrence of seizures occurred in 18 (26.5%) patients following phenytoin therapy. In 16 patients, the seizure recurrence occurred between the loading dose and first maintenance dose at 6 hours. There was no statistical difference in the clinical characteristics of those who had seizure recurrence compared with those that did not. Seizure recurrence following phenytoin therapy in eclampsia is unacceptably high. These results suggest that phenytoin is not effective as a prophylactic anticonvulsant in eclampsia. No conclusions about its effectiveness compared with alternative prophylactic anticonvulsants can be made from this descriptive study.
Naidu
S
S
MRC/UN Pregnancy Hypertension Research Unit, Institute of Biostatistics, Faculty of Medicine, University of Natal, Durban, South Africa.
Moodley
J
J
Gouws
E
E
Motlhabani
B
B