The effect of adsorption, filter material and point of dilution on antibiotic elimination by haemofiltration an in vitro study of levofloxacin.
We studied an in vitro model of continuous venous-venous haemofiltration (CVVH), into which levofloxacin 100 mg was infused, to determine levofloxacin adsorption and to determine the effect of filter material and point of dilution (pre- or post-filter) on sieving coefficient. Mean (standard deviation; S.D.) adsorption was 18.7 (5.3) mg for the polyamide filter and 40.2 (2.0) mg for the polyacrylonitrile (PAN) filter (P < 0.001). Post-dilution resulted in a minor, but statistically significant, decrease in sieving coefficient (pre-dilution 0.96 (S.D. 0.10), post-dilution 0.88 (S.D. 0.11) with the PAN filter. These data indicate that the variability in published values for levofloxacin sieving coefficient are not due to variation in point of dilution or membrane type (PAN or polyamide). Significant adsorption of levofloxacin onto PAN filters occurs.
Choi
Gordon
G
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Gomersall
Charles D
CD
Lipman
Jeff
J
Wong
April
A
Joynt
Gavin M
GM
Leung
Patricia
P
Ramsay
Sarah J
SJ
Ho
Oi Man
OM
D017583:Hemodiafiltration / Q000379:methods; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D064704:Levofloxacin; D008567:Membranes, Artificial; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017582:Renal Replacement Therapy / Q000379:methods / Q000592:standards*
D008567:Membranes, Artificial; D064704:Levofloxacin; D015242:Ofloxacin