title: Modulation of the primary and the secondary antibody response by tobacco smoke condensates.
abstract: Cigarette smoke condensate administered to C57BL/6 mice led to a decrease in the primary antibody response to OVA (hen egg albumin) antigen. Selenium (Se)-supplementation allowed to relieve significantly this inhibition. Moreover, even being not supplemented with Se, a preparation was found devoid of inhibitory effects. Furthermore, the presence of Se-supplemented tobacco smoke condensate at the time of antigen priming, contributed to an enhanced secondary antibody response.
authors.affiliation: Laboratoire de Toxicologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, 75006 Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Nguyen Van Binh
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
authors.forename: Françoise
authors.initials: F
authors.lastname: Baudouin
authors.forename: Chantal
authors.initials: C
authors.lastname: Martin
authors.forename: Martine
authors.initials: M
authors.lastname: Radionoff
authors.forename: Hélène
authors.initials: H
authors.lastname: Dutertre
authors.forename: Véronique
authors.initials: V
authors.lastname: Marchand
authors.forename: Marc
authors.initials: M
authors.lastname: Thevenin
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Warnet
authors.forename: Huynh
authors.initials: H
authors.lastname: Thien Duc
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D007106:Immune Sera / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000009:adverse effects; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D007106:Immune Sera; D007166:Immunosuppressive Agents; D014028:Tobacco Smoke Pollution; D010047:Ovalbumin