title: Geometric strategies for neuroanatomic analysis from MRI.
abstract: In this paper, we describe ongoing work in the Image Processing and Analysis Group (IPAG) at Yale University specifically aimed at the analysis of structural information as represented within magnetic resonance images (MRI) of the human brain. Specifically, we will describe our applied mathematical approaches to the segmentation of cortical and subcortical structure, the analysis of white matter fiber tracks using diffusion tensor imaging (DTI), and the intersubject registration of neuroanatomical (aMRI) data sets. Many of our methods rally around the use of geometric constraints, statistical (MAP) estimation, and the use of level set evolution strategies. The analysis of gray matter structure and connecting white matter paths combined with the ability to bring all information into a common space via intersubject registration should provide us with a rich set of data to investigate structure and variation in the human brain in neuropsychiatric disorders, as well as provide a basis for current work in the development of integrated brain function-structure analysis.
authors.affiliation: Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA. james.duncan@yale.edu
authors.forename: James S
authors.initials: JS
authors.lastname: Duncan
authors.forename: Xenophon
authors.initials: X
authors.lastname: Papademetris
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Marcel
authors.initials: M
authors.lastname: Jackowski
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Zeng
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Staib
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000166:cytology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000166:cytology; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data*; D015233:Models, Statistical; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000166:cytology