2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels.
2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1 K(ATP) channels of beta cells.
Nielsen
Flemming E
FE
Discovery, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark.
Jacobsen
Palle
P
Worsaae
Anne
A
Arkhammar
Per O G
PO
Wahl
Philip
P
Bondo Hansen
John
J
D018528:ATP-Binding Cassette Transporters / Q000819:agonists / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001549:Benzamides / Q000737:chemistry* / Q000494:pharmacology*; D001581:Benzothiadiazines / Q000737:chemistry / Q000494:pharmacology; D003981:Diazoxide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D015221:Potassium Channels / Q000819:agonists / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying / Q000819:agonists / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug / Q000819:agonists / Q000378:metabolism*; D064233:Sulfonylurea Receptors; D013829:Thiadiazines / Q000737:chemistry / Q000494:pharmacology; D000099161:Kcnj11 Channel
D018528:ATP-Binding Cassette Transporters; D000255:Adenosine Triphosphate; D001549:Benzamides; D001581:Benzothiadiazines; D003981:Diazoxide; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D011725:Pyridines; D011955:Receptors, Drug; D064233:Sulfonylurea Receptors; D013829:Thiadiazines; D000099161:Kcnj11 Channel; C416528:7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide; C577509:Abcc8 protein, rat; C099141:BPDZ 62