[Expression of cyclooxygenase-2 and p53 and their correlation in carcinoma of larynx].
OBJECTIVE
To study the expression of cyclooxygenase-2 in laryngeal squamous carcinoma and evaluate the relation between cyclooxygenase-2 and p53.


METHODS
The pathological sections of laryngeal squamous carcinoma was examined by using the method of immunohistochemistry.


RESULTS
Overexpression of Cox-2 and p53 were found in the laryngeal squamous carcinoma specimens; the positive rates of cyclooxygenase-2 and p53 protein expression were 58.7% (37/63) and 63.5% (40/63), respectively. The positive expressions of Cox-2 were related to the clinical stage. The positive expressions of p53 were related to histological grade. There was a positive relationship between Cox-2 and p53.


CONCLUSIONS
Cyclooxygenase-2 plays an important roles in the process of development, growth and invasion of laryngeal squamous carcinoma; and its inhibitors maybe have effect on the development of laryngeal squamous carcinoma.
Lu
Haitao
H
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Gong
Shusheng
S
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D008565:Membrane Proteins; D016159:Tumor Suppressor Protein p53; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases