Hodgkin' s disease with fulminant non-alcoholic steatohepatitis.
We report a woman with daily febrile episodes who developed fulminant hepatic failure. A percutaneous liver biopsy demonstrated non-alcoholic steatohepatitis, with no evidence of neoplastic infiltration. Post-mortem examination revealed stage IV Hodgkin's disease with trivial liver involvement. Rapidly progressive steatohepatitis causing acute liver failure may be a paraneoplastic presentation of Hodgkin's disease, possibly mediated by cytokines.
Kosmidou
I S
IS
Department of Internal Medicine, Caritas Saint Elizabeth's Medical Centre and Tufts University Medical School, Boston, MA, 02135, USA.
Aggarwal
A
A
Ross
J J
JJ
Worthington
M G
MG
D000368:Aged; D001706:Biopsy; D020776:Endoscopes, Gastrointestinal; D005234:Fatty Liver / Q000150:complications* / Q000473:pathology; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000503:physiopathology; D017114:Liver Failure, Acute / Q000209:etiology*; D003294:Seizures, Febrile / Q000209:etiology; D014057:Tomography, X-Ray Computed