Histochemical study of mast cells from the thymus of mice receiving ACTH1-24.
Synthetic ACTH1-24 analogue administered in a daily dose of 0.01 mg/kg decreased the number and size of mast cells and increased intracellular serotonin concentration. ACTH1-24 induced degranulation of young mast cells and release of undersulfated heparin. Correlation analysis showed that hormonal imbalance produced by ACTH1-24 was accompanied by redistribution of bioamines.
Naumova
E M
EM
Laboratory of the Department for Medical Biology, Chuvash State University, Cheboksary. nema@chuvsu.ru
Sergeeva
V E
VE
D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D003366:Cosyntropin / Q000008:administration & dosage / Q000494:pharmacology*; D006493:Heparin / Q000032:analysis / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D003366:Cosyntropin; D012701:Serotonin; D006493:Heparin