RNA and microRNAs in fragile X mental retardation.
Fragile X syndrome is caused by the loss of an RNA-binding protein called FMRP (for fragile X mental retardation protein). FMRP seems to influence synaptic plasticity through its role in mRNA transport and translational regulation. Recent advances include the identification of mRNA ligands, FMRP-mediated mRNA transport and the neuronal consequence of FMRP deficiency. FMRP was also recently linked to the microRNA pathway. These advances provide mechanistic insight into this disorder, and into learning and memory in general.
Jin
Peng
P
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Alisch
Reid S
RS
Warren
Stephen T
ST
D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D014176:Protein Biosynthesis; D012313:RNA / Q000502:physiology*; D018911:Trinucleotide Repeats
D035683:MicroRNAs; D012313:RNA