Cerebroprotective effect of combined treatment with pyrazidol and bemitil in craniocerebral trauma.
Monotherapy of consequences of craniocerebral trauma with pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemitil in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemitil was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemitil had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.
Zarubina
I V
IV
Department of Pharmacology, S. M. Kirov Military Medical Academy, Russian Ministry of Defense, St. Petersburg.
Kuritsyna
N A
NA
Shabanov
P D
PD
D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001562:Benzimidazoles / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D006259:Craniocerebral Trauma / Q000188:drug therapy* / Q000378:metabolism; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004734:Energy Metabolism / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D000975:Antioxidants; D001562:Benzimidazoles; D002227:Carbazoles; D018696:Neuroprotective Agents; C049825:bemethyl; C009830:pirlindole