title: High expression of endothelial cell nitric oxide synthase in peritumoral microvessels predicts increased disease-free survival in colorectal cancer.
abstract: We have previously shown that a high frequency of microvessels expressing endothelial cell nitric oxide synthase (ecNOS) in the area surrounding the primary tumor (peritumoral ecNOS-expressing microvessel density: PEMVD) is a favorable prognostic indicator in breast cancer. Studies of a retrospective material of 186 colorectal tumors (Duke's stage B) now show that PEMVD is a significant and independent prognostic indicator for disease-free survival also in these patients. These data reinforce our hypothesis that a high level of expression of ecNOS in microvessels in the tumor-adjacent area protects against tumor metastasis.
authors.affiliation: Division of Cell Biology, Department of Anatomy and Physiology, KVL, Gronnegaardsvej 7, Dk-1870 Frederiksberg C/Copenhagen, Denmark.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Mortensen
authors.forename: Ib Jarle
authors.initials: IJ
authors.lastname: Christensen
authors.forename: Hans Jørgen
authors.initials: HJ
authors.lastname: Nielsen
authors.forename: Ulla
authors.initials: U
authors.lastname: Hansen
authors.forename: Lars-Inge
authors.initials: LI
authors.lastname: Larsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D019001:Nitric Oxide Synthase