[Clinical study on compatibility and dismantlement of Xuefu Zhuyu decoction].
OBJECTIVE
To investigate the regularity of traditional Chinese compound prescription by observing the clinical effect of the compatibility and dismantlement of Xuefu Zhuyu decoction on blood stasis and stagnation of qi syndrome of angina.


METHODS
123 outpatients were randomly divided into Xuefu Zhuyu group(XF), Jingzhi Xuefu Zhuyu group(JZ), Yaodui group(YD) and placebo group and treated.


RESULTS
The array of angina effect and blood stasis and qi stagnation of syndrome effect was XF group, JZ group, YD group, placebo group( P < 0.01). The levels of blood viscosity, platelet adhesiveness, RED transfigure were significantly different before and after treatment in XF group (P < 0.05). The levels of blood viscosity, platelet adhesiveness were significant different before and after treatment in JZ group ( P < 0.05). The levels of blood plasma viscosity, platelet adhesiveness were significantly different before and after treatment in YD group ( P < 0.05). The levels of platelet adhesiveness, RED transfigure were significantly different before and after treatment in placebo group (P < 0.05). There are no difference among levels of blood lipoprotein and ET of four groups ( P > 0.05). Significant difference was found among four groups in increase of NO and t-PA and decrease of IL-6 (P < 0.05).


CONCLUSIONS
The clinical effect and indexes amelioration are correlated to the combination of prescription and the corresponding degree of prescription to syndrome. There are same material foundation in the series of Xuefu Zhuyu dismantle decoction, but the function degree and targets are different with the change of herbs. The method of conjugating disease and syndromes, and prescription to syndromes are a practical pattern to expound the relationship between disease and syndrome.
Wang
Jie
J
Xiyuan Hospital of China Academy of Traditional Chinese Medicine, Beijing 100091, China. wangjie0103@yahoo.com.cn
Jing
Lu
L
Zhong
Jing-Bai
JB
Wang
Yong-Yan
YY
Ma
Li-Hong
LH
Liu
Jian-Gang
JG
D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000188:drug therapy*; D001809:Blood Viscosity / Q000187:drug effects; D004311:Double-Blind Method; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D006400:Hematocrit; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D010946:Plants, Medicinal / Q000737:chemistry; D010973:Platelet Adhesiveness / Q000187:drug effects; D010959:Tissue Plasminogen Activator / Q000097:blood
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D009569:Nitric Oxide; D010959:Tissue Plasminogen Activator