[Assessment of the usefulness of the presence of antithyroid peroxidase antibodies (TPOAb) in patients with end-stage renal failure treated with hemodialysis].
Due to a high frequency of autoimmune diseases in patients with ESRF we observed for 4 years 8 patients treated with HD with high level of TPOAb and 8 patients without TPOAb. Aim of the study was to estimate the role of TPOAb as a prognostic factor of hypothyreosis. We observed in a 4-years follow-up significant increase of TSH (p<0.05) in patients with high TPOAb level. fT3 and fT4 did't change in this time. In the group without TPOAb we observed significant (p<0.01) decrease of fT3 probably due to the disturbances in T4 to T3 conversion. Our results don't permit us to draw a final conclusions but induce us to further observation of hypothyreosis development in patients with ESRF.
Niemczyk
Stanisław
S
Oddzial Chorób Wewnetrznych ze Stacja Dializ SZPOZ w Wołominie. stdializwolomin@poczta.onet.pl
Panasiuk-Jarzyło
Elzbieta
E
Matuszkiewicz-Rowińska
Joanna
J
Niemczyk
Longin
L
D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
D001323:Autoantibodies; D013972:Thyrotropin; D007453:Iodide Peroxidase; D013974:Thyroxine