title: Cellular mechanisms of T cell mediated drug hypersensitivity.
abstract: Noncovalent drug presentation leads to the activation of drug-specific T cells. In some patients with hypersensitivity, such a response occurs within hours even upon the first exposure to the drug. Thus, the reaction to the drug might not be due to a classical, primary response, but rather mediated by existing, preactivated T cells that are cross specific for the drug, and have an additional (peptide) specificity as well.
authors.affiliation: Division of Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology, PKT2 D572, Inselspital, CH-3010 Berne, Switzerland.
authors.forename: Basil O
authors.initials: BO
authors.lastname: Gerber
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Pichler
mesh_terms: D000818:Animals; D004342:Drug Hypersensitivity / Q000235:genetics / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D006801:Humans; D010455:Peptides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014162:Transfection
chemical_list: D006241:Haptens; D010455:Peptides; D011948:Receptors, Antigen, T-Cell