Evaluation of coronary artery remodeling in patients with acute coronary syndrome and stable angina by multislice computed tomography.
BACKGROUND
Multislice computed tomography (MSCT) was used to evaluate coronary artery remodeling in patients with acute coronary syndrome (ACS) and stable angina (SA).


RESULTS
MSCT was performed in 31 patients with ACS and 26 patients with SA and intravascular ultrasound (IVUS) was performed in 28 of these 57 patients. In both the MSCT and IVUS analyses, coronary artery remodeling was assessed by the remodeling index (RI): RI >1.10 was defined as positive coronary artery remodeling (PCAR) and RI <0.95 was defined as negative coronary artery remodeling (NCAR). The RI assessed by MSCT closely correlated with that of IVUS (r=0.86, n=28). The vessel area at the region of maximum luminal narrowing was also comparable between the MSCT and IVUS measurements (r=0.92). PCAR was present in 19 patients (61.3%) with ACS, but in none of the patients with SA (p<0.0001). However, NCAR was present in only 1 patient with ACS (3.2%), but was present in 18 patients (62.9%) with SA. The RI was significantly larger in patients with ACS (1.19+/-0.18) than in those with SA (0.89+/-0.10, p<0.0001).


CONCLUSIONS
MSCT accurately assesses coronary artery remodeling.
Imazeki
Takako
T
Division of Cardiology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan.
Sato
Yuichi
Y
Inoue
Fumio
F
Anazawa
Takeo
T
Tani
Shigemasa
S
Matsumoto
Naoya
N
Takayama
Tadateru
T
Uchiyama
Takahisa
T
Saito
Satoshi
S
D000208:Acute Disease; D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001158:Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018084:Ultrasonography, Interventional