[Preliminary study of the frequency of micronuclei in buccal mucosa cells sampled from patients with laryngeal tumors].
The examination of frequency of micronuclei was carried out on two groups of patients with tumors of upper respiratory tract: cancer of larynx (36 individuals) and polyps of larynx (13 persons). Groups of habitants from Katowice, Czestochowa and Nowy Sacz (cities with the different level of air pollution) and separately group of smokers, were considered as the control. It was observed that high frequency of micronuclei in cell of buccal mucosa from individuals exposed on mutagenic substances from the air and cigarette smoke could be a marker of higher risk of carcinogenesis.
Belowska
Jadwiga
J
Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Fraczek
Agnieszka
A
Rał
Małgorzata
M
Schmager
Jan
J
Składzien
Jacek
J
Strek
Paweł
P
Scióg
Anna
A
Trybała
Dorota
D
D000397:Air Pollution / Q000009:adverse effects*; D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D009061:Mouth Mucosa / Q000166:cytology / Q000378:metabolism; D009153:Mutagens / Q000009:adverse effects; D011127:Polyps / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D014408:Biomarkers, Tumor; D005819:Genetic Markers; D009153:Mutagens