title: Two-year clinical follow-up results of intracoronary radiation therapy with rhenium-188-diethylene triamine penta-acetic acid-filled balloon.
abstract: We investigated the 2-year clinical follow-up results as well as 6-month angiographic and clinical follow-up results of intracoronary radiation therapy using a rhenium-188-diethylene triamine penta-acetic acid ((188)Re-DTPA)-filled balloon system. The study comprised of 161 patients with significant de novo (83%) or in-stent restenosis (17%) lesions. Irradiation to deliver 17.6 Gy at a depth of 1.0 mm into the vessel wall was carried out after successful intervention. At 6-month follow-up, binary restenosis developed with significantly lower frequency in the radiation group than in the control group (24.3% vs. 46.3%; P = 0.009), although target lesion revascularization rate did not show significant benefit. At 2-year follow-up, cumulative target lesion revascularization rate was not significantly different between radiation group (n = 86) and control group (n = 75; 20.0% vs. 26.0%; P = 0.368). The rate of major adverse cardiac events including death, myocardial infarction, and target lesion revascularization did not show significant difference between two groups either (22.3% vs. 30.1%; P = 0.266). In conclusion, although significant reduction in restenosis rate was noted at 6-month angiographic follow-up, intracoronary radiation therapy mostly in patients with de novo lesion did not show significant clinical benefit in 6-month and 2-year follow-up results. The benefit was noted only in a small subgroup of patients with in-stent restenosis.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Cho
authors.forename: Myung-A
authors.initials: MA
authors.lastname: Kim
authors.forename: Kyung-Kuk
authors.initials: KK
authors.lastname: Hwang
authors.forename: Bon-Kwon
authors.initials: BK
authors.lastname: Koo
authors.forename: Seil
authors.initials: S
authors.lastname: Oh
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Chae
authors.forename: Hyo-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Byung-Hee
authors.initials: BH
authors.lastname: Oh
authors.forename: Myoung-Mook
authors.initials: MM
authors.lastname: Lee
authors.forename: Young-Bae
authors.initials: YB
authors.lastname: Park
authors.forename: Yun-Shik
authors.initials: YS
authors.lastname: Choi
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000532:radiotherapy; D023921:Coronary Stenosis / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid; D011446:Prospective Studies; D015641:Radiography, Interventional; D011868:Radioisotopes / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D012211:Rhenium / Q000008:administration & dosage*
chemical_list: D011868:Radioisotopes; D012211:Rhenium; D004369:Pentetic Acid