title: The first regioselective palladium-catalyzed indolization of 2-bromo- or 2-chloroanilines with internal alkynes: a new approach to 2,3-disubstituted indoles.
abstract: [reaction: see text] The first practical and economical process for synthesis of 2,3-disubstituted indole compounds has been developed with high regioselectivity by palladium-catalyzed indolization of 2-bromo- or chloroanilines and their derivatives with internal alkynes.
authors.affiliation: Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., 800 East Leigh Street, Suite 205, Richmond, Virginia 23219, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.forename: Guisheng
authors.initials: G
authors.lastname: Li
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Lu
authors.forename: Azad
authors.initials: A
authors.lastname: Hossain
authors.forename: Frank
authors.initials: F
authors.lastname: Roschangar
authors.forename: Vittorio
authors.initials: V
authors.lastname: Farina
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake