title: Polymer-based paclitaxel-eluting stents in percutaneous coronary intervention: a review of the TAXUS trials.
abstract: Drug-eluting stents have altered the practice of interventional cardiology by dramatically reducing the risk of angiographic and clinical restenosis following percutaneous coronary intervention. Based on extensive preclinical study and clinical trial data, the polymer-based, slow rate-release paclitaxel-eluting TAXUS stent has recently received Food and Drug Administration approval for sale in the United States. In the current article, we review the available data from the TAXUS trials that have demonstrated that implantation of the slow rate-release TAXUS stent is safe and, in terms of restenosis, markedly superior to bare metal stenting for the treatment of de novo lesions <28 mm in length in arteries 2.5-3.75 mm in diameter. Additional trials in the TAXUS program are currently examining the role of slow and moderate rate-release polymer-based, paclitaxel-eluting stents in a broader range of clinical settings and lesion subsets.
authors.affiliation: Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, 55 E. 59th Street, New York City, NY 10022, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Halkin
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D020099:Coated Materials, Biocompatible; D003324:Coronary Artery Disease / Q000628:therapy; D023903:Coronary Restenosis / Q000517:prevention & control*; D004343:Drug Implants; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage*; D010865:Pilot Projects; D011108:Polymers; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D011108:Polymers; D017239:Paclitaxel