A novel preparation of solid lipid nanoparticles with cyclosporin A for prolonged drug release.
Solid lipid nanoparticles were prepared by a novel solvent diffusion method in an aqueous system. The lipophilic model drug cyclosporin A was incorporated into SLN to study encapsulation efficiency, zeta potential (charge) and drug delivery. Stearylamine and cyclosporin A were dissolved in ethanol and acetone and the resultant organic solution was dropped into water at 60 degrees C. The drug-loaded SLN suspension quickly formed with an azury color. After burst drug release with 18% of the drug over the first 12 hours, a distinctly prolonged release over a monitored period of 16 days was observed, with nearly 4% of the drug being released each day. These results demonstrate the suitability of SLN produced with the proposed method as a prolonged release formulation for lipophilic drugs.
Hu
F Q
FQ
School of Pharmaceutical Science, Zhejiang University, Hangzhou, PR China. pharmnet@cps.zju.edu.cn
Wu
M Zh
MZh
Yuan
H
H
Zhang
H H
HH
D000588:Amines; D016572:Cyclosporine / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004058:Diffusion; D004339:Drug Compounding; D005079:Excipients; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000737:chemistry; D007700:Kinetics; D008055:Lipids; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D010316:Particle Size; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D012997:Solvents; D013501:Surface-Active Agents
D000588:Amines; D003692:Delayed-Action Preparations; D005079:Excipients; D007166:Immunosuppressive Agents; D008055:Lipids; D012997:Solvents; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D016572:Cyclosporine; C009317:stearylamine