Comparison of cardiac troponin T and I in healthy men and in aortic valve replacement.
Troponins are of outstanding importance for the diagnosis of myocardial infarction. Cardiac troponin T (cTnT) and the various cardiac troponin I (cTnI) assays differ with respect to method comparison, diagnostic sensitivity and diagnostic specificity. To understand the differences in the diagnostic behavior of troponin assays, AccuTnI and Elecsys Troponin STAT were used in a group of healthy men and in the follow-up of patients with aortic valve replacement (AVR). Within the healthy subjects AccuTnI was able to differentiate two subgroups from each other, whereas the cTnT concentrations of all subjects were below the detection limit. In AVR patients, cTnT and cTnI correlated sufficiently, if the postoperative periods were taken into consideration. There was a rapid increase in cTnI within 24 h. In contrast, a broad peak was evident for cTnT between 48 and 120 h. The results emphasize more the differences in the release of cTnI and cTnT from the cytoplasm and the thin filaments of the cardiomyocytes than the modifications of the troponins circulating in the blood.
Gurr
Eberhard
E
Department of Clinical Chemistry, Zentralkrankenhaus Links der Weser, Bremen, Germany. gurr.e@zkhldw.de
Leitz
Knut
K
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D003593:Cytoplasm; D003937:Diagnosis, Differential; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D032383:Myocytes, Cardiac / Q000737:chemistry; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000032:analysis*; D020107:Troponin T / Q000032:analysis*
D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T