The influence of relative humidity and temperature on stability of moexipril hydrochloride in solid phase.
Kinetic and thermodynamic parameters of the decomposition of moexipril hydrochloride in solid phase in the absence and presence of humidity were calculated. The evaluation of stability of moexipril hydrochloride was followed by the HPLC method. The applied method was validated (evaluation of the following parameters: selectivity, linearity, precision, limit of detection (LOD), limit of quantification (LOQ) and repeatability). The effect of humidity on the stability of MHCl in solid phase at 363 K was described by the equation: In ki = ax + b = (0.0676 +/- 0.016) . RH% - (15.53+/-0.78). Identification of degradation products of MHCl were carried out by the HPLC-MS method.
Stanisz
Beata
B
Poznań, University of Medical Sciences, Department of Pharmaceutical Chemistry, Poland.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D006813:Humidity / Q000009:adverse effects*; D013696:Temperature; D044005:Tetrahydroisoquinolines / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism*
D044005:Tetrahydroisoquinolines; C058302:moexipril