Nonsecretory multiple myeloma with amyloidosis. A case report and review of the literature.
We report a case concerning a 49-year-old female patient with thoracic pain. X-rays showed a single osteolytic lesion on the right seventh rib. The excision of the rib disclosed a plasmocytic plasmocytoma with extensive amyloidosis. Serum and urine protein electrophoresis were both negative for monoclonal gammopathy. Bone marrow biopsy showed that 80% of the marrow had been replaced by plasma cells. A diagnosis of nonsecretory multiple myeloma was made. Immunohistochemistry revealed amyloid light (AL) amyloidosis of kappa-light chain origin. The relationship between nonsecretory multiple myeloma and amyloidosis is discussed.
Gafumbegete
Evariste
E
Department of Pathology, University of Rostock, Germany.
Richter
Susann
S
Jonas
Ludwig
L
Nizze
Horst
H
Makovitzky
Josef
J
D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000378:metabolism* / Q000473:pathology; D001797:Blood Protein Electrophoresis; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism* / Q000648:ultrastructure
D000682:Amyloid; D007136:Immunoglobulins