title: A model for the oscillatory motion of single dynein molecules.
abstract: Axonemal dynein is the molecular motor responsible for the rhythmic beating of eukaryotic cilia and flagella. An individual axonemal dynein molecule is capable of both unidirectional and oscillatory motion along a microtubule (Nature 393 (1998) 711). We propose a model which links the physical motion of a two-headed dynein molecule to its ATP hydrolysis cycle, and which exhibits both processive and oscillatory behaviors. A mathematical analysis of the model is used to make experimentally testable predictions.
authors.affiliation: Biomathematics Graduate Program, North Carolina State University, Raleigh, NC 27695-8203, USA.
authors.forename: D Michael
authors.initials: DM
authors.lastname: Goedecke
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Elston
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D004398:Dyneins / Q000502:physiology*; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology*; D013269:Stochastic Processes
chemical_list: D020409:Molecular Motor Proteins; D004398:Dyneins