title: The effect of clozapine on factors controlling glucose homeostasis.
abstract: BACKGROUND
  This prospective study examines the effect of clozapine on factors determining glucose homeostasis.
  
  
  METHODS
  The sample consisted of all patients meeting DSM-IV criteria for schizophrenia who commenced clozapine treatment within the South London and Maudsley hospitals during 1 year (2000-2001). Growth hormone (GH), insulin-like growth factor-1 (IGF-1), and IGF binding protein-1 (IGFBP-1) were measured in 19 patients (10 female; mean age = 31.1 years [SD = 5.8]; 9 black British/African, 10 white British) before and after a mean of 2.5 (SD = 0.9) months of clozapine treatment.
  
  
  RESULTS
  Baseline IGFBP-1 was low. IGFBP-1, GH, and IGF-1 were not significantly changed by clozapine treatment.
  
  
  CONCLUSIONS
  Clozapine does not alter GH, IGF-1, or IGFBP-1 within 3 months of commencing treatment, indicating that alteration in glucose tolerance associated with clozapine treatment involves other mechanisms yet to be elucidated. Baseline abnormalities in IGFBP-1 indicate a preexisting susceptibility to glucoregulatory dysfunction.
authors.affiliation: Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom. O.Howes@iop.kcl.ac.uk
authors.forename: Oliver D
authors.initials: OD
authors.lastname: Howes
authors.forename: Fiona P
authors.initials: FP
authors.lastname: Gaughran
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Amiel
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.forename: Lyn S
authors.initials: LS
authors.lastname: Pilowsky
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D015992:Body Mass Index; D003024:Clozapine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D019382:Human Growth Hormone / Q000097:blood / Q000187:drug effects; D006801:Humans; D007118:Immunoassay; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood / Q000187:drug effects; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000187:drug effects; D008163:Luminescent Measurements; D008297:Male; D011446:Prospective Studies; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D018970:Insulin-Like Growth Factor Binding Protein 1; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D003024:Clozapine