Effects of meloxicam on severity of lameness and other clinical signs of osteoarthritis in dogs.
OBJECTIVE
To evaluate effects of meloxicam on severity of lameness and other clinical signs in dogs with osteoarthritis (OA).


METHODS
Randomized, controlled, multicenter clinical trial.


METHODS
217 client-owned dogs with clinical and radiographic signs of OA.


METHODS
Dogs were randomly assigned to be treated with meloxicam (n = 105; 0.2 mg/kg [0.09 mg/lb], SC, once on day 1, then 0.1 mg/kg [0.045 mg/lb], PO, q 24 h, for 13 days) or a placebo (n = 112). A general clinical score was assigned by investigators on days 1 (ie, prior to initiation of treatment), 8, and 15 on the basis of severity of lameness, extent of weight bearing, and severity of signs during palpation of the affected joint. Owners and investigators provided overall evaluations on days 8 and 15.


RESULTS
Dogs treated with meloxicam had significantly greater improvements in general clinical scores, compared with baseline scores, on days 8 and 15 than did dogs treated with placebo. On days 8 and 15, percentages of dogs treated with meloxicam in which owners and investigators considered treatment to be successful were significantly higher than percentages of control dogs in which treatment was considered to be successful. No abnormalities in hematologic and serum biochemical test results were detected.


CONCLUSIONS
Results suggest that compared with administration of a placebo, administration of meloxicam for 14 days significantly improved the clinical condition of dogs with OA without causing adverse effects.
Peterson
Kurt D
KD
Boehringer Ingelheim Vetmedica Inc, 2621 N Belt Hwy, St Joseph, MO 64506, USA.
Keefe
Thomas J
TJ
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007279:Injections, Subcutaneous / Q000662:veterinary; D007794:Lameness, Animal / Q000188:drug therapy*; D000077239:Meloxicam; D010003:Osteoarthritis / Q000188:drug therapy / Q000662:veterinary*; D011897:Random Allocation; D012720:Severity of Illness Index; D013843:Thiazines / Q000009:adverse effects / Q000627:therapeutic use*; D013844:Thiazoles / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam