Aetiological factors in paediatric urolithiasis.
The aetiology of stones in children differs from that in adults. Young children, especially boys, are prone to infective stones, although this type of calculi is decreasing in frequency over time in prosperous countries. Two monogenic causes, cystinuria and hyperoxaluria, each account for 5-15% of paediatric stones. Increased factors for stone formation in children include prematurity, neurological problems, ketogenic diet and reconstructed or augmented bladders. Hypercalciuria is commonly found in paediatric stone formers, is usually idiopathic and is only rarely associated with hypercalcaemia. All children with stones should undergo a metabolic evaluation.
van't Hoff
William G
WG
NephroUrology Unit, Great Ormond Street Hospital for Children, London, UK. anthw@gosh.nhs.uk
D002118:Calcium / Q000652:urine; D002648:Child; D003555:Cystinuria / Q000150:complications; D006801:Humans; D006959:Hyperoxaluria / Q000150:complications; D011687:Purines / Q000032:analysis / Q000378:metabolism; D014545:Urinary Calculi / Q000737:chemistry / Q000209:etiology* / Q000652:urine; D014552:Urinary Tract Infections / Q000150:complications
D011687:Purines; D002118:Calcium; C030985:purine