title: Increased plasma 8-isoprostane levels in hypertensive subjects: the Tsurugaya Project.
abstract: To examine the relationship between 8-isoprostane and blood pressure, we measured plasma 8-isoprostane concentration and home blood pressure levels in an elderly Japanese population. Our study population comprised 569 subjects aged 70 years and over who were not receiving antihypertensive medication. On the basis of their blood pressure values, the participants were classified into three groups: normotensive (home blood pressure <135/85 mmHg), hypertensive (home blood pressure 135/85-160/90 mmHg), and severely hypertensive (home blood pressure > or =160/90 mmHg). The mean plasma 8-isoprostane level in the severely hypertensive group (21.1+/-5.2 pg/ml) was significantly higher than that in the normotensive (20.2+/-4.9 pg/ml) or hypertensive (19.7+/-5.1 pg/ml) group, and this result was unchanged when we adjusted for possible confounding factors such as age, sex, use of vitamin A, C or E supplements, smoking status, drinking status, body mass index, use of non-steroidal anti-inflammatory drugs, history of diabetes, hypercholesterolemia, home heart rate and serum creatinine level. Thus, the level of plasma 8-isoprostane appears to be elevated in older subjects with severe hypertension.
authors.affiliation: Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan. hozawa@mail.tohoku.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hozawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Ebihara
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohmori
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Ugajin
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Matsui
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tsubono
authors.forename: Hidetada
authors.initials: H
authors.lastname: Sasaki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuji
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007564:Japan; D008297:Male; D018384:Oxidative Stress; D012720:Severity of Illness Index; D014505:Urban Population
chemical_list: C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost