Is adjuvant therapy necessary for peritoneal cytology-positive surgical-pathologic Stage I endometrial cancer? Preliminary results.
OBJECTIVE
To compare the clinical and laboratory findings between adjuvant therapy performed and not performed on peritoneal cytology-positive patients with cytology-negative cases of surgical-pathologic Stage I endometrial cancer.


METHODS
Twelve peritoneal cytology-positive and 12 negative surgical-pathologic Stage I endometrial cancer cases were used in the study. Adjuvant radiotherapy was performed for six cytology-positive patients (group I); no adjuvant therapy was performed for six cytology-positive (group II) and 12 cytology-negative patients (control group). Pelvic examination, vaginal cytology, serum CA125 levels and routine blood tests were checked at two-month intervals for two years and at six-month intervals for the third year. Abdominopelvic computerized tomography was planned annually.


RESULTS
There was no statistically significant difference among the three groups and no recurrence in any group.


CONCLUSIONS
We do not recommend adjuvant therapy for cytology-positive patients if the tumor is confined to the uterus.
Dede
M
M
Department of Obstetrics & Gynecology, Gynecologic Oncology Unit, Gülhane Military Medical Academy, Ankara (Turkey).
Yenen
M C
MC
Goktolga
U
U
Duru
N K
NK
Guden
M
M
Dilek
S
S
Pabuccu
R
R
D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery*; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery*; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome