title: Elevated soluble cell adhesion molecules E-selectin and intercellular cell adhesion molecule-1 in type-2 diabetic patients with and without asymptomatic peripheral arterial disease.
abstract: OBJECTIVE
  Cell adhesion molecules may serve as markers of endothelial cell activation, and they may well have a role in the pathogenesis of atherosclerotic vascular disease in diabetes mellitus.
  
  
  METHODS
  
  
  
  METHODS
  a cross sectional, comparative study.
  
  
  METHODS
  a teaching University Hospital. Patients and controls. A cohort of diabetic patients with absent peripheral arterial pulses but no history of cardiovascular or cerebrovascular disease i.e. asymptomatic (n=29), median age 68 (36-80) years, (range), diabetes duration 10 (1-43) years and HbA1c 7.7% (4.8-9.6). They were compared to 12 age and sex matched normal non-diabetic controls.
  
  
  METHODS
  none.
  
  
  METHODS
  soluble cell adhesion molecules intercellular cell adhesion molecule-1 (ICAM-1) and E-selectin levels measured by ELISA methods.
  
  
  RESULTS
  The 29 patients with diabetes, as a whole, were found to have significantly higher median plasma sICAM-1 and sE-selectin of 283 ng/ml (154-1000) (range), and 65.8 ng/ml (20.6-145) vs 237 (147-312.4) and 37.7 (19.8-46.6) respectively, Mann Whitney U test p<0.02, and p<0.002. In the diabetic group, E-selectin correlated with ICAM-1, age and HbA1c: r=0.524 p<0.01, r=0.385 p<0.05 and r=0.393 p<0.05 respectively (Spearman correlation coefficient).
  
  
  CONCLUSIONS
  These results confirm that elevated levels of adhesion molecules, E-selectin and ICAM-1 occur in Type-2 diabetes early in the course of asymptomatic peripheral arterial occlusive disease, and this is related to glycemic control. This suggests that adhesion molecules may have a role in the pathogenesis of atherosclerotic vascular disease in diabetes.
authors.affiliation: Section of Vascular Biology and Medicine, University and Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland, UK. tarikelhadd@aol.com
authors.forename: T A
authors.initials: TA
authors.lastname: Elhadd
authors.forename: G
authors.initials: G
authors.lastname: Kennedy
authors.forename: R
authors.initials: R
authors.lastname: Robb
authors.forename: M
authors.initials: M
authors.lastname: McLaren
authors.forename: R T
authors.initials: RT
authors.lastname: Jung
authors.forename: J J F
authors.initials: JJ
authors.lastname: Belch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood*
chemical_list: D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1