Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese.
Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.
Nawata
Hajime
H
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shirasawa
Senji
S
Department of Pathology, Research Institute, International Medical Center, Tokyo, Japan.
Nakashima
Naoki
N
Department of Medical Informatics, Kyushu University Hospital, Fukuoka, Japan.
Araki
Eiichi
E
Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Hashiguchi
Jun
J
Tenposan Clinic, Kagoshima, Japan.
Miyake
Seibei
S
Sasebo Central Hospital, Nagasaki, Japan.
Yamauchi
Teruaki
T
Yukuhashi Central Hospital, Fukuoka, Japan.
Hamaguchi
Kazuyuki
K
Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan.
Yoshimatsu
Hironobu
H
Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan.
Takeda
Haruo
H
Yatsushiro General Hospital, Kumamoto, Japan.
Fukushima
Hideo
H
Public Tamana Central Hospital, Kumamoto, Japan.
Sasahara
Takayuki
T
Omuta Tenryo Hospital, Fukuoka, Japan.
Yamaguchi
Kohei
K
Oita Prefectural Hospital, Oita, Japan.
Sonoda
Noriyuki
N
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sonoda
Tomoko
T
Sonoda Clicin, Kagoshima, Japan.
Matsumoto
Masahiro
M
Kitakyushu Municipal Medical Center, Fukuoka, Japan.
Tanaka
Yoshiya
Y
First Department of Internal Medicine, School of Medicine, University of Occupational & Environmental Health, Fukuoka, Japan.
Sugimoto
Hidekatsu
H
Sugimoto Clinic, Fukuoka, Japan.
Tsubouchi
Hirotaka
H
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Inoguchi
Toyoshi
T
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yanase
Toshihiko
T
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Wake
Nakayasu
N
National Health Insurance Takachiho Town Hospital, Miyazaki, Japan.
Narazaki
Kenziro
K
Narazaki Clinic, Fukuoka, Japan.
Eto
Takashi
T
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Umeda
Fumio
F
Diabetology and Endocrinology Division of Internal Medicine, Fukuoka Medical Association Hospital, Fukuoka, Japan.
Nakazaki
Mitsuhiro
M
Department of Cardiovascular, Respiratory & Metabolic Medicine Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.
Ono
Junko
J
Department of Laboratory Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan.
Asano
Takashi
T
First Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan.
Ito
Yasuko
Y
Furugou Clinic, Oita, Japan.
Akazawa
Shoichi
S
Shin-Koga Hospital, Fukuoka, Japan.
Hazegawa
Iwaho
I
Kamiamakusa General Hospital, Kumamoto, Japan.
Takasu
Nobuyuki
N
Department of Endocrinology and Metabolism, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Shinohara
Moritsugu
M
National Health Insurance Matsubase Town Hospital, Kumamoto, Japan.
Nishikawa
Takeshi
T
Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Nagafuchi
Seiho
S
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Okeda
Toshimitsu
T
Shin-Kokura Hospital, Fukuoka, Japan.
Eguchi
Katsumi
K
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Iwase
Masanori
M
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ishikawa
Mayuko
M
Department of Pathology, Research Institute, International Medical Center, Tokyo, Japan.
Aoki
Masayuki
M
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Keicho
Naoto
N
Research Institute, International Medical Center of Japan, Tokyo, Japan.
Kato
Norihiro
N
Research Institute, International Medical Center of Japan, Tokyo, Japan.
Yasuda
Kazuki
K
Research Institute, International Medical Center of Japan, Tokyo, Japan.
Yamamoto
Ken
K
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Sasazuki
Takehiko
T
International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. sasazuki@nciryo.hosp.go.jp.
D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D007564:Japan; D008126:Lod Score