Expression of adhesion molecules and Ki-67 in female adnexal tumor of probable Wolffian origin (FATWO): report of two cases and review of the literature.
Female adnexal tumor of probable Wolffian origin (FATWO) is a rare entity which is believed to originate from mesonephric (Wolffian) remnants on the basis of its location where the remnants are abundant. Its behavior is usually indolent, although some cases can recur or metastasize. The authors present the clinicopathological features of two cases of FATWO arising in the broad ligament, and focus on the expression of adhesion molecules and proliferative marker. Mesonephric duct remnants are also examined in an attempt to elucidate the histogenesis of FATWOs. The two FATWOs were well-circumscribed solid masses arising in the leaves of the broad ligament and histological examination revealed a mixture of cysts and tubules imparting a sieve-like pattern and mucin-negative eosinophilic secretion within these tubules. Immunohistochemically, the tumors showed the expression of cytokeratin 7 and 20, high-molecular-weight cytokeratin, and calretinin, which closely resembled that of the mesonephric duct remnants. Regarding CK 20, CD 10, EMA, S-100 protein, and vimentin their expression was in part not identical with previous studies. E-cadherin, alpha and beta-catenin were strongly expressed along the cell membrane of the tumor cells. The Ki-67 labeling index of FATWO was 0% and 3.2% in each case. The preservation of the E-cadherin-catenin complex and low Ki-67 labeling index could explain the indolent behavior and low malignant potential of this tumor.
Li
Chiun Chei
CC
Department of Pathology and Laboratory Medicine, Veterans General Hospital-Taipei, Taipei, and National Yang-Ming University, Taiwan.
Qian
Zhi Rong
ZR
Hirokawa
Mitsuyoshi
M
Sano
Toshiaki
T
Pan
Chi Chen
CC
Hsu
Chih Yi
CY
Yang
An Hang
AH
Chiang
Hung
H
D000291:Adnexal Diseases / Q000196:embryology / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D001956:Broad Ligament; D064032:Calbindin 2; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D005833:Genital Neoplasms, Female / Q000196:embryology / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism*; D008875:Middle Aged; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D014928:Wolffian Ducts / Q000196:embryology
C576764:CALB2 protein, human; D064032:Calbindin 2; D015815:Cell Adhesion Molecules; D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D019394:Ki-67 Antigen; D064030:S100 Calcium Binding Protein G; D007633:Keratins