title: Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep.
abstract: (1) Prostaglandin D2 is essential for the maintenance of the sleep state. (2) The adenosine and A2A receptor system is a link between the humoral and neural mechanisms of sleep-wake regulation. (3) Prostaglandin D2 plays a crucial role in the homeostatic regulation of NREM sleep. Finally, it may not be too far-fetched to say that prostaglandin D2 was most likely the endogenous sleep substance described by Piéron and Ishimori about 100 years ago, and possibly the sleep-inducing factor reported by Professor Jouvet and coworkers some twenty years ago.
authors.affiliation: Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 5650874, Japan. hayaishi@obi.or.jp
authors.forename: O
authors.initials: O
authors.lastname: Hayaishi
authors.forename: Y
authors.initials: Y
authors.lastname: Urade
authors.forename: N
authors.initials: N
authors.lastname: Eguchi
authors.forename: Z L
authors.initials: ZL
authors.lastname: Huang
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000201:enzymology / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D054834:Lipocalins; D051379:Mice; D015230:Prostaglandin D2 / Q000096:biosynthesis* / Q000235:genetics; D043705:Receptor, Adenosine A2A / Q000235:genetics / Q000378:metabolism; D011971:Receptors, Immunologic / Q000235:genetics*; D011982:Receptors, Prostaglandin / Q000235:genetics*; D012890:Sleep / Q000235:genetics / Q000502:physiology*
chemical_list: D054834:Lipocalins; D043705:Receptor, Adenosine A2A; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor