title: Rapidly progressed secondary amyloidosis in a patient with mixed connective tissue disease.
abstract: A 39-year-old woman with mixed connective tissue disease suddenly developed repeated watery diarrhea two years after the onset of the disease. A colonic biopsy specimen revealed amyloid A protein deposition and the diagnosis of secondary amyloidosis was established. The amyloid deposition disappeared after the 8-month course of the treatment with prednisolone and azathioprine. Molecular genetic analysis showed the presence of the gamma-allele in her serum amyloid A protein 1 gene. This might be associated with the early onset and progression of secondary amyloidosis in our case, just like cases reported in rheumatoid arthritis.
authors.affiliation: Department of Internal Medicine, Ugo Municipal Hospital, Ogachi-gun.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kimura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Komatsuda
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Sawada
authors.forename: Akio
authors.initials: A
authors.lastname: Mimori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Baba
authors.forename: Seiji
authors.initials: S
authors.lastname: Minota
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000235:genetics; D000685:Serum Amyloid A Protein / Q000235:genetics
chemical_list: D000685:Serum Amyloid A Protein