Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U.
We examined the effects of centrally administered neuromedin U (NMU) on corticotrophin-releasing factor (CRF)-containing neurons in the hypothalamic paraventricular nucleus (PVN) of rats, using double immunohistochemistry for CRF and Fos. Almost all CRF-containing neurons in the parvocellular divisions of the PVN expressed Fos-like immunoreactivity 90 min after intracerebroventricular administration of NMU (3 nmol/rat). This results suggest the possibility that central NMU may be involved in stress-induced activation of CRF-containing neurons in the PVN.
Yokota
Makoto
M
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Ozaki
Yumi
Y
Sakamoto
Fumihiko
F
Yamada
Seiji
S
Saito
Jun
J
Fujihara
Hiroaki
H
Ueta
Yoichi
Y
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009474:Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000008:administration & dosage* / Q000494:pharmacology; D010286:Paraventricular Hypothalamic Nucleus; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D009479:Neuropeptides; D016760:Proto-Oncogene Proteins c-fos; C056900:neuromedin U; D003346:Corticotropin-Releasing Hormone