title: Asymmetric synthesis of C-aliphatic homoallylic amines and biologically important cyclohexenylamine analogues.
abstract: An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Chi-Lik
authors.initials: CL
authors.lastname: Ken Lee
authors.forename: Hui Yvonne
authors.initials: HY
authors.lastname: Ling
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D003510:Cyclohexanes / Q000138:chemical synthesis*; D053138:Cyclohexenes; D007097:Imines / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000588:Amines; D003510:Cyclohexanes; D053138:Cyclohexenes; D007097:Imines; C052568:cyclohexene