Hallmarks of 'BRCAness' in sporadic cancers.
Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-repair processes. Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' - that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCA2-mutation carriers. These common properties might have important implications for the clinical management of these cancers.
Turner
Nicholas
N
The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
Tutt
Andrew
A
Ashworth
Alan
A
D019313:BRCA1 Protein / Q000502:physiology; D024682:BRCA2 Protein / Q000502:physiology; D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D005199:Fanconi Anemia / Q000235:genetics; D052236:Fanconi Anemia Complementation Group D2 Protein; D052219:Fanconi Anemia Complementation Group F Protein; D005260:Female; D020869:Gene Expression Profiling; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology; D010641:Phenotype; D016601:RNA-Binding Proteins / Q000502:physiology; D011995:Recombination, Genetic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D019313:BRCA1 Protein; D024682:BRCA2 Protein; D004273:DNA, Neoplasm; C499905:FANCD2 protein, human; C499901:FANCF protein, human; D052236:Fanconi Anemia Complementation Group D2 Protein; D052219:Fanconi Anemia Complementation Group F Protein; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins