title: [Synthesis and antitumor activities of 10-hydroxy camptothecin derivatives].
abstract: OBJECTIVE
  To find new anticancer drug based on the structure of 10-hydroxy camptothecin.
  
  
  METHODS
  Seven camptothecin derivatives (3 -9) were synthesized and the antitumor activities of these derivatives were evaluated.
  
  
  RESULTS
  Structures of seven new compounds were determined by 1HNMR, IR, MS. Seven compounds showed inhibitory effects on Hela, BEL-7402, 7901 cell lines in vitro. Especially, compound 4 showed high bioactivities to all of the tumor cells in vitro, its anticancer activity against human cervical carcinoma Hela was much higher than that of 10-hydroxy camptothecin.
  
  
  CONCLUSIONS
  Some compounds are worth further studying.
authors.affiliation: Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, China.
authors.forename: Qing-Yong
authors.initials: QY
authors.lastname: Li
authors.forename: Yuan-Gang
authors.initials: YG
authors.lastname: Zu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Fu
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; C028098:10-hydroxycamptothecin; D002166:Camptothecin