Cobalt(I)-mediated [2 + 2 + 2] cyclization of allenediynes toward a diastereoselective approach to 11-aryl steroid skeletons.
[reaction: see text] An 11-aryl steroid skeleton has been built in one step with a simultaneous introduction of the substituents at both C11 and C10 in 48% overall yield from a trans-allenediyne, whereas a formal Alder ene reaction leading to a bicyclic yne-trienic compound becomes the major process from the cis-allenediyne.
Petit
Marc
M
Laboratoire de Chimie Organique associé au CNRS, Université Pierre et Marie Curie (Paris 6), Tour 44-54, 2 étage, Case 229, 4 Place Jussieu, F-75252 Paris Cedex 05, France.
Aubert
Corinne
C
Malacria
Max
M