title: Antenatal risk factors associated with the development of lenticulostriate vasculopathy (LSV) in neonates.
abstract: OBJECTIVE
  To determine the antenatal risk factors associated with neonatal lenticulostriate vasculopathy (LSV).
  
  
  METHODS
  Women in preterm labor were randomized to magnesium sulfate (MgSO4), other tocolytic, or saline control. The surviving babies underwent head ultrasounds (HUS) (weeks of life 1, 2, and 4) and periodic developmental examinations (months 4, 8, 12, and 18).
  
  
  RESULTS
  Of 140 infants, 17.1% (24) had neonatal intraventricular hemorrhage (IVH), and 10.0% (14) had LSV (half of the latter (7 of 14) had both IVH and LSV). In a regression model in which other risk factors were controlled for, the association between antenatal exposures to tocolytic MgSO4 >or=50 g and LSV were significant (adjusted odds ratio (OR), 8.3; 95% confidence interval (CI), 1.5 to 45.0; p=0.01).
  
  
  CONCLUSIONS
  Based on our data and their analyses, we infer that antenatal exposure to high-dosage, tocolytic MgSO4 may be associated with LSV.
authors.affiliation: Department of Obstetrics and Gynecology (R.M., J.G.G.), Loyola University Medical Center, Maywood, IL 60153, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Mittendorf
authors.forename: Karl
authors.initials: K
authors.lastname: Kuban
authors.forename: Peter G
authors.initials: PG
authors.lastname: Pryde
authors.forename: John G
authors.initials: JG
authors.lastname: Gianopoulos
authors.forename: David
authors.initials: D
authors.lastname: Yousefzadeh
mesh_terms: D000328:Adult; D020144:Basal Ganglia Cerebrovascular Disease / Q000139:chemically induced*; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D015149:Tocolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D015149:Tocolytic Agents; D008278:Magnesium Sulfate