title: Outcome of patients with esophageal carcinoma and suspicious celiac lymph nodes as determined by endoscopic ultrasonography.
abstract: OBJECTIVE
  The management of patients with esophageal cancer with malignant celiac lymph nodes (CLNs) is controversial. In this study we evaluated the management and survival of patients with positive CLN findings on endoscopic ultrasonography (EUS) and compared the outcome in surgically treated patients with that of nonsurgically treated patients.
  
  
  METHODS
  The EUS database of the Academic Medical Center was retrospectively searched for patients with esophageal carcinoma and EUS-positive CLN. Follow-up comprised the review of medical charts and contact with general practitioners.
  
  
  RESULTS
  From 1993 through 2000, 78 patients with esophageal carcinoma and suspicious CLN were eligible for inclusion in this study. The median survival of patients with CLN size < 2 cm was 13.5 months vs. 7.0 months for patients with CLN size >2 cm ( P = 0.01). In a multivariate model, CLN size was the only predictive factor for poor patient survival. Of the 78 study patients, 13 underwent a surgical resection and 65 received nonsurgical treatment. The surgical group was significantly younger and all patients in this group had CLN size < 2 cm. The median survival for the surgical group was 13.7 months vs. 13.5 months for the nonsurgical group with CLN size < 2 cm ( P = 0.63).
  
  
  CONCLUSIONS
  In this retrospective study, CLN size was a significant predictor for poor survival. The surgically treated patients had a medium-term survival similar to that of nonsurgically treated patients with a CLN size < 2 cm. These findings underline the prognostic value of CLN size in patients with esophageal carcinoma.
authors.affiliation: Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands. w.a.marsman@amc.uva.nl
authors.forename: W A
authors.initials: WA
authors.lastname: Marsman
authors.forename: M
authors.initials: M
authors.lastname: van Wissen
authors.forename: J J
authors.initials: JJ
authors.lastname: Bergman
authors.forename: J J
authors.initials: JJ
authors.lastname: van Lanschot
authors.forename: H
authors.initials: H
authors.lastname: Obertop
authors.forename: G N
authors.initials: GN
authors.lastname: Tytgat
authors.forename: P
authors.initials: P
authors.lastname: Fockens
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016208:Databases, Factual; D019160:Endosonography; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome