title: Ductal lavage using medically aseptic technique in women at high risk for breast cancer.
abstract: Ductal lavage of the breast is a minimally invasive procedure used to collect epithelial cells from the lumen of the ductolobular system for cytologic analysis. The purpose of this study was to determine the safety of using an aseptic technique in performing ductal lavage. The study included 114 consecutive patients at high risk for breast cancer with clinically negative mammograms and no palpable masses. Ductal lavage could not be performed on 32 of the 114 patients (28%): 26 because nipple aspirate fluid could not be obtained, and 6 because a fluid-yielding duct could not be cannulated. Ductal lavage was successfully performed on 82 patients (72%). Local anesthetic cream was used on the nipple area and local anesthetic was infused into each duct. The nipple, the cup of the nipple aspirator device, and any dilator tools were cleansed with alcohol before use. Separate sterile microcatheters were used for each duct. Sterile saline solution was used for the infusions. No patient reported any symptoms indicating infection after lavage. Cytologic analysis from the 82 lavage cases showed 45 benign cells (55%), 17 cases of mild atypia (21%), 1 case of marked atypia, and 1 case with malignant cells. Eighteen samples (22%) had inadequate cellularity for medical diagnosis. The results of the study indicate that an aseptic technique is safe and appropriate for ductal lavage of the breast.
authors.affiliation: Department of Surgery, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL, USA. darius_s_francescatti@rush.edu
authors.forename: Darius S
authors.initials: DS
authors.lastname: Francescatti
authors.forename: Larry
authors.initials: L
authors.lastname: Kluskens
authors.forename: Lisa
authors.initials: L
authors.lastname: Shah
mesh_terms: D001207:Asepsis / Q000379:methods; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D010045:Outpatients; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D007507:Therapeutic Irrigation / Q000379:methods*