TGFBR1*6A is not associated with prostate cancer in men of European ancestry.
The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case-control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the (*)6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.
Suarez
B K
BK
Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid, St Louis, M) 63110, USA. bks@themfs.wustl.edu
Pal
P
P
Jin
C H
CH
Kaushal
R
R
Sun
G
G
Jin
L
L
Pasche
B
B
Deka
R
R
Catalona
W J
WJ
D030201:Activin Receptors, Type I / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D044465:White People
D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human