Synthesis and antihyperglycemic activity profiles of novel thiazolidinedione derivatives.
A number of thiazolidine-2,4-diones derivatives having carboxylic ester appendage at N-3 were synthesized and their antihyperglycemic activity was evaluated. Many of these derivatives as well as their corresponding carboxylic acid showed significant improvement on post-prandial hyperglycemia in normal rats, in contrast to their poor agonist activity at PPARgamma.
Bhat
Bashir A
BA
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Ponnala
Shashikanth
S
Sahu
Devi Prasad
DP
Tiwari
Priti
P
Tripathi
Brajendra K
BK
Srivastava
Arvind K
AK
D000818:Animals; D002460:Cell Line; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D047495:PPAR gamma / Q000378:metabolism; D051381:Rats; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D007004:Hypoglycemic Agents; D047495:PPAR gamma; D045162:Thiazolidinediones