Loss of caspase-2, -6 and -7 expression in gastric cancers.
Caspases play an essential role during apoptotic cell death, and alterations of caspases are known to contribute to human cancer development. In the current study, we analyzed the expression of caspase-2, -6 and -7 in 120 gastric carcinomas by immunohistochemistry using a tissue microarray approach. Caspase-2, -6 and -7 were expressed in 42 (35%), 63 (53%) and 39 (33%) of the gastric cancers, respectively. By contrast, the surface mucous cells and mucosal glandular cells in the normal gastric mucosa showed strong immunoreactivity for caspase-2, -6 and -7. Taken together, these results indicate that caspase-2, -6 and -7 expression in gastric cancer cells is decreased compared to in normal gastric mucosal cells, and suggest that loss of caspase-2, -6 and -7 expression might be involved in the mechanisms of gastric cancer development.
Yoo
Nam Jin
NJ
Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee
Jong Woo
JW
Kim
Yun Ju
YJ
Soung
Young Hwa
YH
Kim
Su Young
SY
Nam
Suk Woo
SW
Park
Won Sang
WS
Lee
Jung Young
JY
Lee
Sug Hyung
SH
D053143:Caspase 2; D053178:Caspase 6; D053179:Caspase 7; D020169:Caspases / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D015536:Down-Regulation; D005753:Gastric Mucosa / Q000201:enzymology; D006801:Humans; D007150:Immunohistochemistry; D040081:Protein Array Analysis; D013274:Stomach Neoplasms / Q000201:enzymology*
C490360:CASP2 protein, human; C505514:CASP6 protein, human; C505520:CASP7 protein, human; D053143:Caspase 2; D053178:Caspase 6; D053179:Caspase 7; D020169:Caspases; D003546:Cysteine Endopeptidases