title: Five-year incidence of cataract in older persons with diabetes and pre-diabetes.
abstract: OBJECTIVE
  To investigate longitudinal associations between diabetes and the 5-year incidence of cataract and cataract surgery. (A population-based, cohort study of 2335 persons with baseline ages 49 years or older resident in the Blue Mountains region, west of Sydney, Australia).
  
  
  METHODS
  Baseline information on diabetes history was collected during an interviewer-administered questionnaire. Impaired Fasting Glucose (IFG) was defined as venous plasma glucose between 6.0 and 7.0 mmol/L and newly diagnosed diabetes as plasma glucose >7.0 mmol/L, using fasting blood glucose measurements taken at baseline. Retroillumination lens photographs from the baseline and 5-year follow-up examinations were graded for presence of cortical, posterior subcapsular (PSC) and nuclear cataract.
  
  
  RESULTS
  We found a 2-fold higher 5-year incidence of cortical cataract in participants with IFG, multivariate adjusted odds ratio (OR) 2.2, 95% confidence interval (CI) 1.1-4.1. Incident PSC cataract was more frequent among persons with diabetes, but this association was statistically significant only for those with newly diagnosed diabetes, multivariate adjusted OR 4.5 (CI 1.5-13.0). There were no statistically significant associations found between incident nuclear cataract or cataract surgery and either diabetes or IFG.
  
  
  CONCLUSIONS
  These epidemiological data suggest that IFG, a pre-diabetic condition, may be a risk factor for the development of cortical cataract.
authors.affiliation: University of Sydney, Department of Ophthalmology, Westmead Millennium Institute, Centre for Vision Research, Westmead Hospital, Sydney, Australia.
authors.forename: Sonia
authors.initials: S
authors.lastname: Saxena
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
authors.forename: Elena
authors.initials: E
authors.lastname: Rochtchina
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000175:diagnosis / Q000453:epidemiology*; D002387:Cataract Extraction; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D018149:Glucose Intolerance / Q000150:complications; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D013997:Time Factors