CD4+ Tregs and immune control.
Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.
Fehérvari
Zoltán
Z
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. zed72@frontier.kyoto-u.ac.jp
Sakaguchi
Shimon
S
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D051858:Forkhead Transcription Factors; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007108:Immune Tolerance; D008024:Ligands; D051379:Mice; D008954:Models, Biological; D010641:Phenotype; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D012097:Repressor Proteins / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*; D013950:Thymus Gland / Q000378:metabolism / Q000502:physiology
C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D008024:Ligands; D015375:Receptors, Interleukin-2; D012097:Repressor Proteins