title: Changes in voluntary torque and electromyographic activity following oral baclofen.
abstract: The consequences of baclofen intake on voluntary motor behaviors remain unclear. We studied the effects of single oral doses of baclofen on voluntary, isometric knee extension torques and surface and single motor unit (MU) electromyographic (EMG) activity from the vastus lateralis in 11 individuals without neurological injury. Examination of submaximal to maximal contractions of varying duration performed pre- and post-baclofen ingestion revealed significant decreases in maximal knee torques and EMG magnitude, accompanied by an increase in slope of the torque-EMG relation. A decreased slope of the torque-MU firing rate relation was also demonstrated post-baclofen, but without changes in minimal firing rates or recruitment forces. During sustained contractions at < or =25% of maximal voluntary torque elicited after baclofen ingestion, increased EMG activity was observed without significant differences in MU firing rates. Our results demonstrate a clear reduction in the maximal torque-generating ability following baclofen. Specific changes in MU firing patterns indicate that weakness may be due partly to reduced motoneuronal excitability, although use of MU discharge patterns to assess these effects is limited in its sensitivity.
authors.affiliation: Department of Physical Therapy, University of Illinois, 1919 West Taylor Street, Fourth Floor, M/C 898, Chicago, Illinois 60612, USA. tgh@uic.edu
authors.forename: T George
authors.initials: TG
authors.lastname: Hornby
authors.forename: C J
authors.initials: CJ
authors.lastname: Heckman
authors.forename: Richard L
authors.initials: RL
authors.lastname: Harvey
authors.forename: W Zev
authors.initials: WZ
authors.lastname: Rymer
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D001418:Baclofen / Q000008:administration & dosage*; D004576:Electromyography / Q000379:methods; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects* / Q000502:physiology*; D007719:Knee Joint / Q000187:drug effects / Q000502:physiology; D008297:Male; D019415:Torque
chemical_list: D001418:Baclofen