Flavonoids and resveratrol as regulators of Ah-receptor activity: protection from dioxin toxicity.
In 2002 FAO and WHO published a joint appeal to state and public organizations and scientific community to take every effort to control the contents of dioxin and related biphenyls in the environment and food products. The toxic effects of dioxin are realized via its interaction with the Ah-receptor. Here we reviewed modern notions about the structure and functions of Ah-receptor. Particular attention was given to antagonists and agonists of the Ah-receptor, including various flavonoids and resveratrol.
Tutel'yan
V A
VA
Institute of Nutrition, Russian Academy of Medical Sciences Moscow.
Gapparov
M M
MM
Telegin
L Yu
LY
Devichenskii
V M
VM
Pevnitskii
L A
LA
D000818:Animals; D004147:Dioxins / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D004787:Environmental Pollution; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005506:Food Contamination; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D015394:Molecular Structure; D018336:Receptors, Aryl Hydrocarbon / Q000819:agonists* / Q000037:antagonists & inhibitors*; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
D004147:Dioxins; D005419:Flavonoids; D018336:Receptors, Aryl Hydrocarbon; D013267:Stilbenes; D000077185:Resveratrol