Unexpected response of hormone-refractory prostate cancer to treatment with an antileukemic chemotherapy regimen.
Our patient was a 61-year-old man with hormone-refractory prostate cancer and a rapidly rising serum prostate-specific antigen level. During the course of therapy for prostate cancer, abnormal blood counts and subsequent bone marrow biopsy led to a diagnosis of acute lymphoblastic leukemia. He was treated with a chemotherapeutic regimen in standard use for lymphoblastic leukemia, which resulted in an unusual response of his prostate cancer, with declining serum prostate-specific antigen levels that had reached undetectable levels at the time of the patient's death from acute sepsis and leukemic relapse. Autopsy showed minimal evidence of prostate cancer, localized to the prostate.
Gandhok
Navjeet
N
Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Sartor
Oliver
O
D000230:Adenocarcinoma / Q000188:drug therapy*; D000813:Anilides / Q000494:pharmacology / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D003520:Cyclophosphamide; D003561:Cytarabine / Q000008:administration & dosage; D003907:Dexamethasone; D004317:Doxorubicin; D019008:Drug Resistance, Neoplasm; D017809:Fatal Outcome; D017273:Goserelin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications; D009570:Nitriles; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012008:Recurrence; D018805:Sepsis / Q000209:etiology; D014105:Tosyl Compounds; D014750:Vincristine
D000813:Anilides; D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D009570:Nitriles; D014105:Tosyl Compounds; D003561:Cytarabine; D017273:Goserelin; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; C053541:bicalutamide; D017430:Prostate-Specific Antigen; D008727:Methotrexate