title: Sensitivity increase in molecular recognition by decrease of the sensing particle size and by increase of the receptor binding site--a case with chemomechanical polymers.
abstract: For the first time it is shown that diminishing the particle size of a chemomechanical polymer leads to a dramatic sensitivity increase, with a large response triggered e.g. by action of external AMP; as illustrated with carbohydrate model complexes in solution, the necessary high binding affinity can be achieved by providing an excess of recognition units in one of the partners.
authors.affiliation: FR Organische Chemie and Institut für Neue Materialien, Universität des Saarlandes, D 66041, Saarbrücken, Germany. ch12hs@rz.uni-sb.de
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Schneider
authors.forename: Liu
authors.initials: L
authors.lastname: Tianjun
authors.forename: Nino
authors.initials: N
authors.lastname: Lomadze
mesh_terms: D001665:Binding Sites; D002241:Carbohydrates / Q000737:chemistry; D008968:Molecular Conformation; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D002241:Carbohydrates; D011108:Polymers