NF-kappaB and the immunoglobulin kappa gene enhancer.
Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-kappaB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin kappa chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-kappaB binding site-mutated enhancer in the correct biological context does not appear to affect kappa gene expression.
Sen
Ranjan
R
Lab. of Cellular and Molecular Biology, National Institute on Aging, 5600 Nathan Shock Dr., Baltimore, MD 21224, USA. rs465z@nih.gov
D004742:Enhancer Elements, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D008957:Models, Genetic; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*
D007145:Immunoglobulin kappa-Chains; D016328:NF-kappa B; D011947:Receptors, Antigen, B-Cell