Characterization of a new HLA-DRB1*01 allele (HLA-DRB1*010203) in a Caucasian Italian family by using sequence-based typing.
We report the identification of an HLA-DRB1*01 nucleotide sequence variant in three members of a Caucasian Italian family by using sequence-based typing. The nucleotide sequence of exon 2 observed in the new allele is identical to that of HLA-DRB1*010201 except in position 189 (codon 34) where the adenine of the consensus was replaced by a guanine and it was designated officially as HLA-DRB1*010203* by the WHO Nomenclature Committee.
Bontadini
A
A
Transfusion Service, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Manfroi
S
S
Delfino
L
L
Fruet
F
F
Iannelli
S
S
Parodi
A M
AM
Ferrara
G B
GB
Conte
R
R
D000483:Alleles; D003062:Codon; D017931:DNA Primers; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D017354:Point Mutation; D017422:Sequence Analysis, DNA
D003062:Codon; D017931:DNA Primers; C497990:DRB1*01:02:03 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains