title: SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
abstract: A clinical strain of Klebsiella pneumoniae carried the bla(SHV-49) gene, encoding a novel inhibitor-resistant beta-lactamase of pI 7.6, derived from SHV-1 by the single substitution M69I. It also harbored a gene differing from bla(SHV-11) by four silent mutations and coding for a penicillinase. Both genes were chromosome located and might represent either a species-specific gene or an acquired resistance gene.
authors.affiliation: Laboratoire de Microbiologie, Faculté de Pharmacie, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. veronique.dubois@bacterio.u-bordeaux2.fr
authors.forename: Véronique
authors.initials: V
authors.lastname: Dubois
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Corinne
authors.initials: C
authors.lastname: Arpin
authors.forename: Laure
authors.initials: L
authors.lastname: Coulange
authors.forename: Cécile
authors.initials: C
authors.lastname: Bebear
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
authors.forename: Claudine
authors.initials: C
authors.lastname: Quentin
mesh_terms: D000368:Aged; D015139:Blotting, Southern; D024881:Drug Resistance, Bacterial; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007525:Isoelectric Focusing; D007700:Kinetics; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology*; D008297:Male; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D013530:Surgical Wound Infection / Q000382:microbiology; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases; C494146:beta-lactamase SHV-49, Klebsiella pneumoniae