Maternal and fetal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3, and their relationship to fetal acidosis at delivery.
OBJECTIVE
To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and in fetal cord blood at delivery.


METHODS
Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, Illinois, USA), with p<0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking and in fetal blood by cord blood analysis at delivery. Cord pH was also recorded.


RESULTS
There was no significant correlation between maternal IGF-1, IGF-2, or IGFBP-3 levels and fetal acidosis. However, a significant correlation does exist between cord IGF-1 levels and fetal acidosis.


CONCLUSIONS
Fetal cord IGF-1 has a significant correlation with fetal acidosis at delivery.
Cooley
Sharon M
SM
Obstetrics Research Department, Rotunda Hospital, Dublin, Ireland. smcooley@hotmail.com
Donnelly
Jennifer C
JC
Geary
Michael P
MP
Rodeck
Charles H
CH
Hindmarsh
Peter C
PC
D000138:Acidosis / Q000097:blood / Q000453:epidemiology; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005316:Fetal Distress / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D008131:London / Q000453:epidemiology; D011247:Pregnancy; D011446:Prospective Studies
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II