title: Changes in hemodynamics and respiration in rats with different resistance to acute hypoxia.
abstract: Effects of acute hypoxia on hemodynamics and respiration were studied in acute experiments on narcotized rats. The animals were divided into groups characterized by high, low-, and medium- resistance to hypoxia by the time of respiration arrest during inhalation of gas mixture containing 3% O2. Hemodynamic parameters of highly resistant animals were higher than in low-resistant rats throughout the entire hypoxic period. The development of a rare (with prolonged inspiratory phase) respiratory rhythm in highly resistant rats is an adaptive reaction, which allows them longer tolerate hypoxia compared to low-resistant animals.
authors.affiliation: Laboratory of Respiration Pathophysiology, Bioengineering Laboratory, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
authors.forename: N V
authors.initials: NV
authors.lastname: Sanotskaya
authors.forename: D D
authors.initials: DD
authors.lastname: Matsievskii
authors.forename: M A
authors.initials: MA
authors.lastname: Lebedeva
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006439:Hemodynamics; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration