title: The efficacy of Sphaeranthus senegalensis Vaill extract against diarrhoea in rats.
abstract: The aqueous extract of Sphaeranthus senegalensis (Asteraceae) was investigated for anti-diarrhoeal activity in rats. Its effect on castor oil-induced diarrhoea and fluid accumulation and on gastrointestinal (charcoal meal) test was evaluated. Results showed that pre-treatment for 30 min with the extract at 50, 100 and 200 mg/kg, p.o. causes a dose-dependent protection against castor oil-induced diarrhoea and intraluminal fluid accumulation and inhibited gastrointestinal transit motility. These results suggest that the plant contain active constituents that may be useful against diarrhoea.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, PMB 21 Abuja, Nigeria. bulusadzu@yahoo.com
authors.forename: B
authors.initials: B
authors.lastname: Adzu
authors.forename: F
authors.initials: F
authors.lastname: Tarfa
authors.forename: S
authors.initials: S
authors.lastname: Amos
authors.forename: K S
authors.initials: KS
authors.lastname: Gamaniel
mesh_terms: D000818:Animals; D019659:Asteraceae; D002368:Castor Oil / Q000633:toxicity; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*; D005772:Gastrointestinal Transit / Q000187:drug effects / Q000502:physiology; D008297:Male; D016488:Medicine, African Traditional; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D002368:Castor Oil