title: Polymorphism and conservation of the genes encoding Qa1 molecules.
abstract: To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1(a)-like and Qa1(b)-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.
authors.affiliation: Indiana University School of Medicine, Evansville Center, 8600 University Blvd., Evansville, IN 47712-3534, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Hermel
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hart
authors.forename: Irfan
authors.initials: I
authors.lastname: Gunduz
authors.forename: Hector
authors.initials: H
authors.lastname: Acton
authors.forename: Christina
authors.initials: C
authors.lastname: Kim
authors.forename: Mark
authors.initials: M
authors.lastname: Wurth
authors.forename: Samina
authors.initials: S
authors.lastname: Uddin
authors.forename: Caryn
authors.initials: C
authors.lastname: Smith
authors.forename: Kirsten
authors.initials: K
authors.lastname: Fischer Lindahl
authors.forename: Carla J
authors.initials: CJ
authors.lastname: Aldrich
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens