Apoptosis of pancreatic acinar cells in acute pancreatitis: is it good or bad?
Acute pancreatitis is a disease of variable severity in which some patients experience mild, self-limited attacks while others manifest a severe, highly morbid, and frequently lethal attack. The events that regulate the severity of acute pancreatitis are, for the most part, unknown. Several recent studies have suggested that the acinar cell response to injury may be an important determinant of disease severity. In these studies, mild acute pancreatitis was found to be associated with extensive apoptotic acinar cell death while severe acute pancreatitis was found to involve extensive acinar cell necrosis but very little acinar cell apoptosis. These observations have led to the hypothesis that apoptosis might be a favorable response to acinar cell and that interventions which favor induction of apoptotic, as opposed to necrotic, acinar cell death might reduce the severity of an attack of acute pancreatitis. This review aims to discuss our current understanding of the contribution of acinar cell apoptosis to the severity of acute pancreatitis.
Bhatia
M
M
Department of Pharmacology, National University of Singapore, Singapore 117597, Singapore. mbhatia@nus.edu.sg
D000208:Acute Disease; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D009336:Necrosis; D009504:Neutrophils / Q000276:immunology; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D010195:Pancreatitis / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D014157:Transcription Factors / Q000378:metabolism
D016207:Cytokines; D014157:Transcription Factors; D020169:Caspases