title: Funneling auxin action: specificity in signal transduction.
abstract: Auxin regulates a broad spectrum of developmental processes, mediating transcriptional regulation via protein degradation. The molecular mechanisms of auxin action are partially understood whereas the molecular basis for developmental specificity in auxin responses is currently unclear. Recent biochemical and chemical-genetics studies have narrowed the search for regulators in auxin signaling that act upstream of auxin-dependent protein degradation. The auxin response requires the degradation of Aux/IAA inhibitors, which causes interacting ARF transcription factors to be released to regulate target genes. There are many ARFs and Aux/IAA proteins in Arabidopsis, and recent genetic studies suggest that their cell-specific combinations may determine the various auxin responses in development.
authors.affiliation: Centre for Plant Molecular Biology (ZMBP), Developmental Genetics, Tübingen University, Auf der Morgenstelle 3, D-72076 Tübingen, Germany. dolf.weijers@zmbp.uni-tuebingen.de
authors.forename: Dolf
authors.initials: D
authors.lastname: Weijers
authors.forename: Gerd
authors.initials: G
authors.lastname: Jürgens
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D015870:Gene Expression; D018506:Gene Expression Regulation, Plant; D007210:Indoleacetic Acids / Q000378:metabolism*; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D018517:Plant Roots / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C503841:ARF1 protein, Arabidopsis; D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; C491592:IAA1 protein, Arabidopsis; D007210:Indoleacetic Acids; D009687:Nuclear Proteins; D010940:Plant Proteins; D014157:Transcription Factors