title: Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in soft tissue sarcoma research.
abstract: The vast majority of soft tissue tumors (STT), especially sarcomas, should be examined according to a national standard for pathologic evaluation, including a national consensus on a grading system and elements of a synoptic pathology report. The margins should be separated into fascial margins and other surgically cut margins. If questions about the diagnosis arise, a second opinion should be sought from an expert in sarcoma pathology. Whenever possible, tissue should be frozen for potential molecular diagnosis and additional tissue banked for research. Finally, there is a need for a national registry for rare sarcoma types.
authors.affiliation: Pennsylvania Hopsital, Philadelphia 19107, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Zhang
authors.forename: John S J
authors.initials: JS
authors.lastname: Brooks
mesh_terms: D018070:Biological Specimen Banks / Q000592:standards; D014408:Biomarkers, Tumor / Q000032:analysis; D002869:Chromosome Aberrations; D005434:Flow Cytometry; D005629:Frozen Sections; D006801:Humans; D007150:Immunohistochemistry; D012042:Registries; D012509:Sarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013048:Specimen Handling / Q000592:standards*
chemical_list: D014408:Biomarkers, Tumor