title: Fish protein improves the total antioxidant status of streptozotocin-induced diabetes in spontaneously hypertensive rat.
abstract: BACKGROUND
  We measured the effects of fish protein (FP) on blood pressure, glycemia and antioxidant status in spontaneously hypertensive (SH) rats with streptozotocin-induced diabetes (STZ).
  
  
  METHODS
  Two groups of 12 rats each were fed 20% casein (C) or FP for 2 months. The total antioxidant status of blood and organs (liver, kidney and heart) was measured by the KRL test. Antioxidant enzyme activities (G-Px, G-Red, and SOD) and antioxidant substances (GSH, NO) were determined in organs, and vitamin C in plasma.
  
  
  RESULTS
  FP lowered blood pressure in SH rats, but not in SH-STZ. Blood and plasma antioxidant status increased 35% and 9%, respectively, with FP in SH-STZ compared to SH rats; when compared to C, these values were more enhanced. SOD activity values were elevated with FP in SH-STZ rats, compared to the C diet, regardless of organ. Higher kidney NO and heart GSH values were noted in SH-STZ rats than SH. In SH rats fed FP, the GSH value was 2.26 times higher in liver, and NO was 3 times higher in heart. Higher NO was noted in kidney (1.84 times) and heart (1.91 times), GSH in heart (1.79 times), and vitamin C in plasma (+46%) in SH-STZ rats with FP than with C.
  
  
  CONCLUSIONS
  Fish protein has a beneficial effect on blood pressure in SH rats but not in SH-STZ, and plays an important role in antioxidative defense. This protein may be useful in future treatments of such diseases as diabetes and hypertension.
authors.affiliation: Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d'Oran Es-Sénia, Oran, Algeria.
authors.forename: Farida Ouda
authors.initials: FO
authors.lastname: Boukortt
authors.forename: Aurélie
authors.initials: A
authors.lastname: Girard
authors.forename: Josiane L
authors.initials: JL
authors.lastname: Prost
authors.forename: Dalila
authors.initials: D
authors.lastname: Ait-Yahia
authors.forename: Malika
authors.initials: M
authors.lastname: Bouchenak
authors.forename: Jacques
authors.initials: J
authors.lastname: Belleville
mesh_terms: D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002364:Caseins / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology; D029941:Fish Proteins / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011918:Rats, Inbred SHR; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D002364:Caseins; D029941:Fish Proteins; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase