Comparison of gastric volumes in response to isocaloric liquid and mixed meals in humans.
OBJECTIVE
To compare gastric volume responses to ingestion of isocaloric liquid or mixed (solid-liquid) meals and document the intra- and interindividual reproducibility of gastric volume measurement using single photon emission computed tomography (SPECT) imaging after i.v. 99mTc-pertechnetate.


METHODS
Eight healthy volunteers performed two studies at least 9 months apart. Gastric volumes were measured after a 317 kcal liquid nutrient meal. Within 2 weeks of the second liquid meal study, participants performed a third study, ingesting an isocaloric mixed meal. The order of the mixed and second liquid meals was randomized; Bland-Altman plot displayed data on repeated studies with liquid meal and paired t-test compared gastric volumes after mixed or liquid isocaloric meals.


RESULTS
Fasting and postprandial gastric volumes associated with the two liquid meals were not significantly different; inter- and intra-individual coefficients of variation were 13 and 13.8%. In response to the mixed meal, there was a lower absolute postprandial volume and lower change in gastric volume over fasting volume compared with the response to the liquid meal (P = 0.0001).


CONCLUSIONS
The SPECT measurement of gastric volumes in response to a nutrient liquid meal is reproducible. The magnitude of the volume response is greater after the liquid meal compared with the isocaloric mixed meal.
De Schepper
H
H
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
Camilleri
M
M
Cremonini
F
F
Foxx-Orenstein
A
A
Burton
D
D
D000328:Adult; D019422:Dietary Sucrose; D004435:Eating / Q000502:physiology*; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008297:Male; D019518:Postprandial Period; D015203:Reproducibility of Results; D013270:Stomach / Q000000981:diagnostic imaging* / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon
D019422:Dietary Sucrose; C082131:Ensure formulated food