title: Congenital hypofibrinogenemia in pregnancy: report of two cases and review of the literature.
abstract: Fibrinogen abnormalities have been implicated in many adverse pregnancy outcomes, mainly spontaneous abortion, placental abruption, and postpartum hemorrhage. Two new cases of congenital hypofibrinogenemia in pregnancy are reported detailing their obstetric course and management. The relevant obstetric and hematologic literature is reviewed, including previous case reports and studies concerning the mechanisms of pregnancy complications. Suggestions for treatment guidelines and management strategies are detailed.
authors.affiliation: High Risk Pregnancy Unit, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Evgenia
authors.initials: E
authors.lastname: Frenkel
authors.forename: Chen
authors.initials: C
authors.lastname: Duksin
authors.forename: Arie
authors.initials: A
authors.lastname: Herman
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Sherman
mesh_terms: D000328:Adult; D000347:Afibrinogenemia / Q000151:congenital* / Q000503:physiopathology / Q000628:therapy; D000818:Animals; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011256:Pregnancy Outcome; D011295:Prenatal Care
chemical_list: D005340:Fibrinogen