title: Phenylpropanoid NF-kappaB inhibitors from Bupleurum fruticosum.
abstract: Two phenylpropanoids from Bupleurum fruticosum (Apiaceae/Umbelliferae) were shown to inhibit the transcriptional activity induced by PMA or TNFalpha of an NF-kappaB-controlled reporter gene. Western blot experiments indicated that the phenylpropanoids did not prevent IkappaBalpha degradation, suggesting that their molecular target is at a post-IKB degradation level. Both compounds prevented cytokine (IL-1, IL-6, TNF, IL-8) release and prostaglandin E2 synthesis.
authors.affiliation: The Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Bremner
authors.forename: S
authors.initials: S
authors.lastname: Tang
authors.forename: H
authors.initials: H
authors.lastname: Birkmayer
authors.forename: B L
authors.initials: BL
authors.lastname: Fiebich
authors.forename: E
authors.initials: E
authors.lastname: Muñoz
authors.forename: N
authors.initials: N
authors.lastname: Marquez
authors.forename: D
authors.initials: D
authors.lastname: Rivera
authors.forename: M
authors.initials: M
authors.lastname: Heinrich
mesh_terms: D019661:Apiaceae; D015153:Blotting, Western; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D008156:Luciferases / Q000235:genetics; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014158:Transcription, Genetic / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D015850:Interleukin-6; D016328:NF-kappa B; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D008156:Luciferases