title: [Study rat nephrotoxicity of Longdan Xiegan Tang].
abstract: OBJECTIVE
  To investigate the nephrotoxocity of Longdan Xiegan Tang in rats, and to test its safety.
  
  
  METHODS
  Sprague-Dauley rats were given Longdan Xiegan Tang 4.5 mL x (100 mg)(-1) Bid for thirty days, and the control group was given NS. MTP, BUN, Cr, MDA, MTP/Ucr and SOD were measured on 1st, 2nd, 3rd, 4th week. The kidney tissues were viewed with light microscopy and electron microscope.
  
  
  RESULTS
  MTP and MTP/Ucr were obviously higher than controls ( P < 0.01), and the other index had no difference (P > 0.05). No remarkable structural change could been seen with light microscopy, but with electron microscope we could find that the basal membranes were thickened and some of foot process were infused.
  
  
  CONCLUSIONS
  Longdan Xiegan Tang will result in injury of kidney function.
authors.affiliation: Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China. pharmacy302@sohu.com
authors.forename: Qing
authors.initials: Q
authors.lastname: Fang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Zhan
authors.forename: Jian-Ling
authors.initials: JL
authors.lastname: Mo
authors.forename: Mei
authors.initials: M
authors.lastname: Sun
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D030012:Gentiana / Q000737:chemistry; D007668:Kidney / Q000648:ultrastructure*; D007672:Kidney Cortex / Q000378:metabolism; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D003404:Creatinine; D013482:Superoxide Dismutase