[Evaluating the impact of human papilloma virus infection on prognosis of juvenile laryngeal papilloma].
OBJECTIVE
To evaluate the relationship between human papilloma virus (HPV) and pathological characteristics of juvenile laryngeal papillomas (JLP).


METHODS
Using polymerase chain reaction protocol, we analyzed paraffin embedded tissue in 25 cases of juvenile laryngeal papilloma and determined the HPV type.


RESULTS
A total HPV infection positive rate was 96%, and HPV11 positive rate was 56%, HPV6 positive rate was 40%. None of all was positive for HPV16, 18, 33, 71% of patients need tracheotomy in HPV11 infection group, and 30% of patients need tracheotomy in HPV6 infecting group. The post-operation relapse rate in HPV11-positive group was 86% ,and in HPV6-positive group was 40%.


CONCLUSIONS
Juvenile laryngeal papilloma is associated with HPV11, HPV6 infection and we considered that HPV11 infection may be the important guideline of the evaluation of disease prognosis.
Chen
Xiaoyun
X
Department of Otolaryngology, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000.
Tan
Yinxia
Y
Li
Zhiyuan
Z
Wu
Jianbo
J
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000821:virology*; D008297:Male; D010212:Papilloma / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections; D011379:Prognosis