[Synthesis and anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives].
OBJECTIVE
To study the anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives.


METHODS
The target compounds were synthesized from p-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice.


RESULTS
Eleven compounds were obtained and confirmed by IR, 1HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity.


CONCLUSIONS
N-(4-arylamidophenyl) methanesulfonamide showed appreciable anti-inflammatory activity.
Lou
Yong-Jun
YJ
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Dong
Jin-Hua
JH
Xu
Li-Ying
LY
Ji
Zhi-Zhong
ZZ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004423:Ear / Q000473:pathology; D004427:Ear Diseases / Q000139:chemically induced / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014992:Xylenes
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D014992:Xylenes