New indole alkaloids from the roots of Ochrosia acuminata.
Two new indole alkaloids, polyneuridine-N-oxide (1) and 17-hydroxy-10-methoxy-yohimbane (2), together with seven known alkaloids were isolated from the roots of Ochrosia acuminata collected in Savu, Indonesia. 9-Methoxyellipticine (3) and ellipticine (4) were responsible for the antitumor activities of the extract. The structures of all compounds were elucidated using MS and NMR methods.
Salim
Angela A
AA
Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
Garson
Mary J
MJ
Craik
David J
DJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004611:Ellipticines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D030011:Ochrosia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
C493700:17-hydroxy-10-methoxy-yohimbane; D000972:Antineoplastic Agents, Phytogenic; D004611:Ellipticines; D026121:Indole Alkaloids; C493699:polyneuridine-N-oxide; C034192:ellipticine; C001729:9-methoxyellipticine