title: [Association between the functional monoamine oxidase A gene polymorphism and aggressively driving behavior].
abstract: OBJECTIVE
  This study is purposed to explore the relationship between aggressively driving behavior and functional polymorphism in the promoter region of the monoamine oxidase-A (MAOA) gene.
  
  
  METHODS
  A total of 348 automobile drivers were investigated with Deffenbacher's driver anger scale, driving vengeance questionnaire (DVQ) and driver aggression behavior questionnaire. Eighty-eight drivers were selected as more, medium and less aggressive group, each. Polymerase chain reaction (PCR) and 2.5% agarose gel electrophoresisi were adopted to detect the polymorphism of functional 30 bp-uVNTR in the promoter region of the X-chromosomal MAOA gene and their frequencies of varied genotypes were estimated.
  
  
  RESULTS
  Two alleles with 3 and 4 repeats of 30 bp-uVNTR were detected in the drivers. Among the more aggressive group, number of the allele with 3 repeats of 30 bp-uVNTR (63/88) was significantly more than that with 4 repeats (25/88) (chi(2) = 10.21, P < 0.01), and number of the allele with 4 repeats of 30 bp-uVNTR was more in the less aggressive group, indicating that persons with allele of 3 repeats of 30 bp VNTR were more aggressive in their driving than those with 4 repeats.
  
  
  CONCLUSIONS
  Aggressively driving behavior in drivers possibly related to their functional MAOA-uVNTR polymorphism. Effect of the gene on aggressively driving behavior should be further studied.
authors.affiliation: Department of Occupational Health, School of Public Health, Sichuan University, Chengdu 610041, China.
authors.forename: Feng-Zhi
authors.initials: FZ
authors.lastname: Li
authors.forename: Chang-Ji
authors.initials: CJ
authors.lastname: Li
authors.forename: Yun-Fang
authors.initials: YF
authors.lastname: Long
authors.forename: Cheng-Lie
authors.initials: CL
authors.lastname: Zhan
authors.forename: Wu
authors.initials: W
authors.lastname: Yao
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
mesh_terms: D000328:Adult; D000374:Aggression / Q000502:physiology*; D001334:Automobile Driving / Q000523:psychology*; D001921:Brain / Q000503:physiopathology; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011985:Receptors, Serotonin / Q000235:genetics; D012701:Serotonin / Q000502:physiology; D011795:Surveys and Questionnaires
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin; D008995:Monoamine Oxidase