title: Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.
abstract: The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Motoyoshi
authors.forename: Masato
authors.initials: M
authors.lastname: Horigome
authors.forename: Ken
authors.initials: K
authors.lastname: Ishigami
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Sueharu
authors.initials: S
authors.lastname: Horinouchi
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hidenori
authors.initials: H
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitahara
mesh_terms: D001710:Biotin / Q000737:chemistry*; D019921:Biotinylation; D002453:Cell Cycle / Q000187:drug effects*; D011714:Pyrans / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013141:Spiro Compounds / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C104486:FR 901464; D011714:Pyrans; D013141:Spiro Compounds; D001710:Biotin