An expansion of Simons' integrated hypothesis of trigger point formation.
Simons' integrated hypothesis proposed a model of trigger point (TrP) activation to explain known TrP phenomena, particularly endplate noise. We propose an expansion of this hypothesis to account for new experimental data and established muscle pathophysiology.
Gerwin
Robert D
RD
Johns Hopkins University Pain and Rehabilitation Medicine, Bethesda, MD 20814-2432, USA. gerwin@painpoints.com
Dommerholt
Jan
J
Shah
Jay P
JP
D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000502:physiology; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009045:Motor Endplate / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000293:injuries / Q000378:metabolism / Q000503:physiopathology; D009209:Myofascial Pain Syndromes / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D009619:Nociceptors / Q000502:physiology; D011950:Receptors, Cholinergic / Q000502:physiology
D011950:Receptors, Cholinergic; D000110:Acetylcholinesterase; D015740:Calcitonin Gene-Related Peptide; D000109:Acetylcholine