Invasive fungal rhinosinusitis in immunocompromised patients.
BACKGROUND
Invasive fungal rhinosinusitis (IFR) is one of the most important causes of morbidity and mortality in immunocompromised patients, principally those with cellular immunodeficiency, with mortality ranging from 50 to 80%. Prophylaxis and early diagnosis increase the chances of successful treatment.


METHODS
Clinical prospective randomized study.


OBJECTIVE
To present cases of IFR and to compare them with data reported in the literature.


METHODS
Analysis of eleven cases of IFR confirmed by pathologist examination.


RESULTS
Aspergillus was found to be the most prevalent pathogen. Symptoms ranged from high fever in most cases to nasal discharge, ulceration of the nasal mucosa, headache and periorbital edema.


CONCLUSIONS
The combination of amphotericin B and endoscopic surgery, associated or not with Caldwell-Luc surgery, showed good results. The use of liposomal amphotericin B also presented a satisfactory outcome.
Anselmo-Lima
Wilma T
WT
Department of Otorhinolaryngology, Ophthalmology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brasil. mcecilia@hcrp.fmrp.usp.br
Lopes
Rony P
RP
Valera
Fabiana C P
FC
Demarco
Ricardo C
RC
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy*; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy*; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B