title: Evaluation of ST-segment changes during and after maximal exercise tests in one-, two- and three-vessel coronary artery disease.
abstract: OBJECTIVE
  To relate ECG and heart rate (HR) variables during and after exercise testing with the presence of one-, two- or three-vessel disease defined by angiography.
  
  
  METHODS
  Seventy-three male patients with stable angina pectoris and angiographically verified coronary artery disease underwent a maximal exercise test. From 12-lead ECG recordings and computer averaging ST-amplitude and HR data were measured in consecutive 10-s intervals.
  
  
  RESULTS
  In univariate analysis, patients with three-vessel disease had lower maximal exercise capacity, a shorter time to >1 mm ST-depression, more often a clockwise ST/HR recovery loop, more frequently a post-exercise downward ST-segment slope, and a greater ST-deficit at 3.5 min after exercise than patients with one-vessel disease. In multivariate analysis, time to >1 mm ST-depression discriminated between patients with three- and one-vessel disease. In patients with an intermediate time to >1 mm ST-depression a clockwise ST/HR recovery loop and/or a downsloping ST-segment in the post-exercise period were significantly more prevalent in severe vessel disease.
  
  
  CONCLUSIONS
  Patients with three-vessel disease had a significantly shorter time to >1 mm ST-depression during exercise and more often an abnormal post-exercise ST/HR reaction than those with one-vessel disease.
authors.affiliation: AstraZeneca R&D, Mölndal, Sweden. thorvald.bjuro@astrazeneca.com
authors.forename: Thorvald
authors.initials: T
authors.lastname: Bjurö
authors.forename: Lars
authors.initials: L
authors.lastname: Gullestad
authors.forename: Knut
authors.initials: K
authors.lastname: Endresen
authors.forename: Margareta
authors.initials: M
authors.lastname: Nordlander
authors.forename: Anders
authors.initials: A
authors.lastname: Malm
authors.forename: Lena
authors.initials: L
authors.lastname: Höglund
authors.forename: Inger
authors.initials: I
authors.lastname: Wahlqvist
authors.forename: John
authors.initials: J
authors.lastname: Pernow
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000175:diagnosis; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000145:classification / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013318:Stroke Volume; D013997:Time Factors