There are no acute cardiac effects of a single iv dose of human ghrelin in severe growth hormone deficient patients.
It has previously been suggested that ghrelin mediates GH-independent biologic activities on the heart. We investigated the acute effects on cardiac contraction of a single iv administration of human ghrelin (in a dose of 1 microg/kg) in severe untreated GH deficient subjects. Prior to the ghrelin infusion, an echocardiographic examination was performed at rest (baseline), after physiologic saline and during dobutamine stress echocardiography (DSE) to exclude a preexisting (subclinical) myocardial dysfunction. To evaluate the acute cardiac effect of infusion and during DSE the velocity of left ventricular (LV) wall contraction was measured continuously by echocardiography. Despite severe GH deficiency we observed in all subjects a normal cardiac function at rest after physiologic saline and during DSE. No acute changes in cardiac performance or cardiac parameters could be observed after a single iv dose of ghrelin. Also, no important increase in GH secretion was detected after ghrelin administration. Our study suggests that, in contrast to hexarelin, a single iv administration of ghrelin in a physiological dose has no acute effects on cardiac function in severe GH deficiency. This suggests that GH-independent effects of ghrelin play no important role in the acute regulation of cardiac function in man.
Janssen
J A M J L
JA
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. j.a.m.j.l.janssen@erasmusmc.nl
Poldermans
D
D
Hofland
L J
LJ
Vourvouri
E C
EC
Muller
A F
AF
Bax
J J
JJ
Deghenghi
R
R
Broglio
F
F
Ghigo
E
E
van der Lely
A J
AJ
D000328:Adult; D004452:Echocardiography; D005260:Female; D054439:Ghrelin; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D036361:Peptide Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D012720:Severity of Illness Index; D016037:Single-Blind Method
D054439:Ghrelin; D036361:Peptide Hormones; D019382:Human Growth Hormone