In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists.
Superantigen peptide antagonists failed to block T-cell activation and cytokine production as well as toxic shock induced by staphylococcal enterotoxin B (SEB) in HLA class II transgenic mice. They also failed to inhibit the binding of SEB to HLA class II molecules as well as activation of human T lymphocytes in vitro.
Rajagopalan
Govindarajan
G
Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Sen
Moon M
MM
David
Chella S
CS
D000595:Amino Acid Sequence; D000818:Animals; D004768:Enterotoxins / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D006683:HLA-DQ Antigens / Q000235:genetics; D015803:HLA-DR3 Antigen / Q000235:genetics; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012772:Shock, Septic / Q000401:mortality*; D018089:Superantigens; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D004768:Enterotoxins; D006683:HLA-DQ Antigens; C109756:HLA-DQ8 antigen; D015803:HLA-DR3 Antigen; D010455:Peptides; D018089:Superantigens; C031818:enterotoxin B, staphylococcal