Tumor-targeting of viral vectors for cancer gene therapy by using antibodies or their genes against tumor-associated antigens.
Gene therapy is a promising modality for the treatment of malignant tumors for which conventional therapies are often inadequate. Various therapeutic genes have shown promise for tumor cell killing. However, successful gene therapy depends on the development of efficient and targeted gene transfer vectors. The aim of this review is to summarize the tumor-targeting viral vectors for cancer gene therapy by utilizing antibodies or genes against tumor-associated antigens.
Kuroki
Masahide
M
Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka, Japan. kurokima@fukuoka-u.ac.jp
Kuroki
Motomu
M
Shibaguchi
Hirotomo
H
Hachimine
Ken
K
Kinugasa
Tetsushi
T
Badran
Adel
A
D000256:Adenoviridae / Q000235:genetics* / Q000276:immunology; D000912:Antibodies, Neoplasm / Q000235:genetics* / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics / Q000276:immunology*; D006801:Humans; D012190:Retroviridae / Q000235:genetics* / Q000276:immunology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm