title: Chromatin dynamics and cancer.
abstract: Chomatin remodeling multi-protein complexes play a key regulatory role in many physiological processes such proliferation and differentiation. The alteration in the recruitment or in the function of one of these chromatin remodeling factors can lead to a proliferation defect, that might result from the aberrant activation or repression of key genes that regulate cell proliferation. In fact, aberrant chromatin remodeling leads to severe human diseases such as leukemia, epithelial cancers and Rubinstein-Taybi syndrome.
authors.affiliation: André Lwoff Institute, Villejuif, France.
authors.forename: Valentina
authors.initials: V
authors.lastname: Guasconi
authors.forename: Slimane
authors.initials: S
authors.lastname: Ait-Si-Ali
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D049109:Cell Proliferation; D002843:Chromatin / Q000378:metabolism*; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D016160:Retinoblastoma Protein / Q000235:genetics
chemical_list: D002843:Chromatin; D006657:Histones; D016160:Retinoblastoma Protein; D000255:Adenosine Triphosphate