[Problems of recurrent loss of pregnancy: are procoagulant microparticles a risk factor for pregnancy outcome?].
BACKGROUND
Circulating procoagulant microparticles (PM) are a novel risk factor for pregnancy outcome. They derive from cytosol and membranes of the cells undergoing apoptosis or pathological activation. Tissue factor and phospholipids are the active components of PM responsible for "placental thrombosis" and pregnancy loss.


METHODS
The paper is a survey of the literature on the pathological role of PM in complicated pregnancy.


CONCLUSIONS
The published studies suggest that PM play a role of a pathogenic factor in women with repeated pregnancy loss. Prophylaxis within low-molecular heparin is a promising clinical procedure.
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Mieczysław
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Katedra i Zakład Propedeutyki Medycznej AM w Bydgoszczy.
D000026:Abortion, Habitual / Q000097:blood / Q000209:etiology*; D000328:Adult; D001775:Blood Circulation; D001779:Blood Coagulation Factors / Q000009:adverse effects / Q000648:ultrastructure; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000209:etiology*; D011256:Pregnancy Outcome; D012307:Risk Factors
D001779:Blood Coagulation Factors