title: Associations between CYP11B2 gene -344T/C polymorphism and essential hypertension in the Han nationality in Shandong province.
abstract: OBJECTIVE
  To investigate whether the -344T/C polymorphism of CYP11B2 gene is associated with essential hypertension in the Hans in Shandong province.
  
  
  METHODS
  Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured with radioimmunoassays; the hypertensives were classified as low-renin and normal- or high-renin group by PAC/PRA ratio. -344T/C polymorphism was determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) in controls and hypertensives.
  
  
  RESULTS
  No significant differences were found in genotype distribution or allele frequency between groups of control and primary hypertension or between groups of control and normal- or high-renin hypertension. The C allele frequency in low-renin hypertension group was significantly higher than that in normotensives and normal- or high-renin hypertension group (P < 0.05).
  
  
  CONCLUSIONS
  These results suggest that -344T/C polymorphism of CYP11B2 gene may be associated with low-renin essential hypertension in the Han nationality in Shandong province.
authors.affiliation: Department of Cardiology, Yuhuangding Hospital of Qingdao University, Yantai, Shandong, PR China. sunxiaojian2002@hotmail.com
authors.forename: Xiao-jian
authors.initials: XJ
authors.lastname: Sun
authors.forename: Xiao-fei
authors.initials: XF
authors.lastname: Hou
authors.forename: Shao-rong
authors.initials: SR
authors.lastname: Liu
authors.forename: Wen-bo
authors.initials: WB
authors.lastname: Liu
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Tao
authors.forename: Jian-yuan
authors.initials: JY
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D019405:Cytochrome P-450 CYP11B2