title: The dopamine D2 receptor C32806T polymorphism (DRD2 Taq1A RFLP) exhibits no association with smoking behaviour in a healthy UK population.
abstract: A single nucleotide polymorphism (SNP) in the Taq1A site near the DRD2 gene has been associated in several studies with smoking behaviour. We genotyped 732 current smokers (241 low, one to nine cigarettes a day, 250 mid, 10-19 cigarettes, 241 high, 20+cigarettes) and 243 never-smokers at this site (C32806T), to test for effects on smoking initiation and amount of tobacco consumed. No significant association between minor allele frequency and smoking status was detected. Multiple regression analysis including DRD2 genotype, sex, age and alcohol consumption as predictors showed that level of cigarette consumption was associated with sex (p=0.003) and age (p=0.002) but not with alcohol consumption (p=0.25) or DRD2 genotype (p=0.76).
authors.affiliation: Cancer Research UK, General Practice Research Group, University of Oxford Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK. elaine.johnstone@clinpharm.ox.ac.uk
authors.forename: E C
authors.initials: EC
authors.lastname: Johnstone
authors.forename: P
authors.initials: P
authors.lastname: Yudkin
authors.forename: S E
authors.initials: SE
authors.lastname: Griffiths
authors.forename: A
authors.initials: A
authors.lastname: Fuller
authors.forename: M
authors.initials: M
authors.lastname: Murphy
authors.forename: R
authors.initials: R
authors.lastname: Walton
mesh_terms: D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking / Q000235:genetics; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012737:Sex Factors; D012907:Smoking / Q000235:genetics*; D013223:Statistics as Topic; D014029:Tobacco Use Disorder / Q000235:genetics
chemical_list: D017448:Receptors, Dopamine D2