[The relationship between serum calcitonin gene-related peptide, sex hormone, homocysteine and coronary artery disease in postmenopausal women].
OBJECTIVE
To investigate the relationship between serum calcitonin gene-related peptide (CGRP), homocysteine (Hcy), sex hormone, and coronary heart disease (CHD) in postmenopausal women.


METHODS
In a cross-sectional study, serum CGRP, estradiol (E(2)), progesterone (P) and Hcy levels of 144 postmenopausal women undergoing diagnostic CHD (75 with CHD and 69 without CHD) and 66 healthy young women were measured.


RESULTS
The occurrence of CHD was correlated with high Hcy level and low CGRP level. The mean serum CGRP level was significantly lower in CHD postmenopausal women than in without CHD ones [(103.6 +/- 59.8) ng/L vs (164.6 +/- 50.7) ng/L, P < 0.01]. The mean serum E(2) level was significantly lower in CHD postmenopausal women than in without CHD ones [(67.9 +/- 24.4) pmol/L vs (91.7 +/- 23.0) pmol/L, P < 0.01]. The mean serum P level was significantly lower in CHD than in without CHD postmenopausal women [(0.89 +/- 0.46) nmol/L vs (1.11 +/- 0.45) nmol/L, P < 0.01]. The mean serum Hcy level was significantly higher in CHD than in without CHD postmenopausal women [(15.3 +/- 6.5) micromol/L vs (10.2 +/- 2.8) micromol/L, P < 0.01]. By multivariate logistic regression, the OR of high Hcy level > or = 1, P < 0.01, that means Hcy is an independent risk factor of CHD. The OR of CGRP, E(2) and P were all < or = 1, indicating that they were independent protective factor.


CONCLUSIONS
Hcy is an independent risk factor of CHD. CGRP, E(2) and P are independent protective factors of CHD. There was no relationship between Hcy, CGRP and E(2) and P.
Wang
Zhen
Z
Department of Emergency, the Third Hospital of Peking University, Beijing 100083, China. wangzhen1369@hotmail.com
Guo
Jing-xuan
JX
Wang
Xian
X
Zhao
Yi-ming
YM
Hou
Ling-fei
LF
D000328:Adult; D000368:Aged; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D003327:Coronary Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D012307:Risk Factors
D006710:Homocysteine; D011374:Progesterone; D004958:Estradiol; D015740:Calcitonin Gene-Related Peptide