Determination of some acidic drugs in surface and sewage treatment plant waters by capillary electrophoresis-electrospray ionization-mass spectrometry.
We describe an analytical method involving solid-phase extraction (SPE) and capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) for determining some pharmaceutical compounds - naproxen, clofibric acid and bezafibrate - in real water samples. The electrospray parameters were optimized to maximize sensitivity. When a mixed aqueous-organic solvent and CZE-ESI-MS were used to analyze these drugs in water samples, the capillary was coated with hexadimethrin bromide (HDB) to permanently reverse the EOF. The method was developed from off-line SPE-CZE-MS and was validated with surface water. The detection limits were 100 ng.L(-1) for all analytes. The method was applied to analyze water samples from the influent and effluent of a sewage treatment plant. A liquid-liquid extraction step was required before SPE, and the compounds studied were found, some of them between detection and quantification limits.
Macià
Alba
A
Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Tarragona, Spain.
Borrull
Francesc
F
Calull
Marta
M
Aguilar
Carme
C
D000143:Acids / Q000032:analysis; D001629:Bezafibrate / Q000032:analysis; D002995:Clofibric Acid / Q000032:analysis; D019075:Electrophoresis, Capillary / Q000379:methods*; D009288:Naproxen / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012722:Sewage / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis*
D000143:Acids; D004364:Pharmaceutical Preparations; D012722:Sewage; D014874:Water Pollutants, Chemical; D002995:Clofibric Acid; D009288:Naproxen; D001629:Bezafibrate