NF-kappaB signaling: flipping the switch with polyubiquitin chains.
Protein modification by ubiquitin has emerged as an important cellular regulatory mechanism. Recent studies illustrate the surprising ways in which polyubiquitin chains are manipulated in the regulation of NF-kappaB signaling.
Ravid
Tommer
T
Yale University, Department of Molecular Biophysics & Biochemistry, 266 Whitney Avenue, P.O. Box 208114 New Haven, Connecticut 06520-8114, USA.
Hochstrasser
Mark
M
D005786:Gene Expression Regulation; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism* / Q000502:physiology; D010766:Phosphorylation; D025821:Polyubiquitin / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016328:NF-kappa B; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; D025821:Polyubiquitin