Effect of ivermectin on function of liver macrophages.
Ivermectin had no effect on phagocytic function of liver macrophages, but blocked LPS-induced secretion of tumor necrosis factor, NO, prostaglandin E2, and increase of intracellular concentration of Ca2+. These inhibitory effects were observed only in the presence of chlorine ions in the extracellular medium, which attested to involvement of glycine-dependent chlorine channels.
Viktorov
A V
AV
Central Institute of Epidemiology, Ministry of Health of Russian Federation, Moscow. farm@newtech.ru
Yurkiv
V A
VA
D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D002712:Chlorides / Q000378:metabolism; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D007559:Ivermectin / Q000494:pharmacology*; D007728:Kupffer Cells / Q000187:drug effects* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000633:toxicity; D008262:Macrophage Activation; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D000977:Antiparasitic Agents; D002712:Chlorides; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D007559:Ivermectin; D015232:Dinoprostone; D002118:Calcium