title: Efficacy of IVF using frozen donor semen in cases of previously failed DI cycles compared with tubal infertility: a cohort study.
abstract: A cohort follow-up study was designed to compare the efficacy of IVF using frozen donor semen (IVF-D) following previously failed DI cycles (unexplained female infertility) and direct IVF-D treatment because of tubal infertility (control group). The cohort comprised 189 couples initiating IVF-D after previously failed DI cycles (n = 126) or directly (n = 63). Couples were followed until completion (success or drop-out for personal or medical reasons). Live births and drop-out were expressed both as rate per cycle and crude cumulative rate. Characteristics of IVF-D cycles were similar between the two groups. Moreover, overall outcome was also similar in terms of crude cumulative live birth rate (54.0 versus 57.1% for failed DI cycles and tubal infertility groups respectively). This is the first report on crude cumulative live birth rate based on a cohort follow-up study in unexplained previously failed DI cycles and tubal infertility. Previously failed DI cycles did not impair the chances of achieving a successful pregnancy using IVF-D in this series. Slight oocyte dysfunction, which might underlie the failure of DI cycles, might be overcome using IVF-D.
authors.affiliation: CECOS, Biologie de la Reproduction, Département de Gynécologie-Obstétrique et Reproduction Humaine, Centre Hospitalier Universitaire Bretonneau, 37044 Tours, France.
authors.forename: F
authors.initials: F
authors.lastname: Guerif
authors.forename: M H
authors.initials: MH
authors.lastname: Saussereau
authors.forename: C
authors.initials: C
authors.lastname: Barthelemy
authors.forename: M L
authors.initials: ML
authors.lastname: Couet
authors.forename: O
authors.initials: O
authors.lastname: Gervereau
authors.forename: J
authors.initials: J
authors.lastname: Lansac
authors.forename: D
authors.initials: D
authors.lastname: Royere
mesh_terms: D000328:Adult; D015331:Cohort Studies; D015925:Cryopreservation; D005184:Fallopian Tube Diseases / Q000150:complications; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007316:Insemination, Artificial, Heterologous; D008297:Male; D011247:Pregnancy; D012662:Semen Preservation