Immunomodulating characteristics of Cys-(Pro)3-Glu-Leu hexapeptide under different experimental conditions.
Cys-(Pro)3-Glu-Leu hexapeptide markedly stimulated activity of human natural killers during the cytotoxic test in the presence of autologous serum, but not fetal calf serum. This effect of hexapeptide on natural killer activity was physiological. Conditions are determined under which hexapeptide stimulates the cytotoxicity in a mode ensuring protection of the microenvironment from damage inflicted by own natural killer cytotoxic factors.
Cheknev
S B
SB
Laboratory of Cell-to-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow. cheknev@riem.ru
D000293:Adolescent; D000328:Adult; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D003470:Culture Media; D003601:Cytotoxicity Tests, Immunologic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology* / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000276:immunology* / Q000494:pharmacology
D003470:Culture Media; D007155:Immunologic Factors; D010446:Peptide Fragments