title: Anion-exchange displacement centrifugal partition chromatography.
abstract: Ion-exchange displacement chromatography has been adapted to centrifugal partition chromatography. The use of an ionic liquid, benzalkonium chloride, as a strong anion-exchanger has proven to be efficient for the preparative separation of phenolic acid regioisomers. Multigram quantities of a mixture of three hydroxycinnamic acid isomers were separated using iodide as a displacer. The displacement process was characterized by a trapezoidal profile of analyte concentration in the eluate with narrow transition zones. By taking advantage of the partition rules involved in support-free liquid-liquid chromatography, a numerical separation model is proposed as a tool for preliminary process validation and further optimization.
authors.affiliation: FRE CNRS 2715 Isolement, Structures, Transformations et Synthèses des Substances Naturelles, IFR 53 Biomolécules, Université de Reims Champagne-Ardenne, Bât. 18, Moulin de la Housse, F-51687 Reims Cedex 2, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Maciuk
authors.forename: Jean-Hugues
authors.initials: JH
authors.lastname: Renault
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Margraff
authors.forename: Philippe
authors.initials: P
authors.lastname: Trébuchet
authors.forename: Monique
authors.initials: M
authors.lastname: Zèches-Hanrot
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Nuzillard