title: No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells.
abstract: Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.
authors.affiliation: Department of Anatomy, Faculty of Science, Mahidol University, Thailand. kawin@tubtim.cri.or.th
authors.forename: Kawin
authors.initials: K
authors.lastname: Leelawat
authors.forename: Surang
authors.initials: S
authors.lastname: Engprasert
authors.forename: Urai
authors.initials: U
authors.lastname: Pongchai-rerk
authors.forename: Supatip
authors.initials: S
authors.lastname: Tuchinda
authors.forename: Cheepsumon
authors.initials: C
authors.lastname: Suthipintawong
authors.forename: Vijittra
authors.initials: V
authors.lastname: Leardkamolkarn
mesh_terms: D018256:Adenomatous Polyps / Q000378:metabolism; D002278:Carcinoma in Situ / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism*; D006680:HLA Antigens / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I