Increased plasma 8-isoprostane levels in hypertensive subjects: the Tsurugaya Project.
To examine the relationship between 8-isoprostane and blood pressure, we measured plasma 8-isoprostane concentration and home blood pressure levels in an elderly Japanese population. Our study population comprised 569 subjects aged 70 years and over who were not receiving antihypertensive medication. On the basis of their blood pressure values, the participants were classified into three groups: normotensive (home blood pressure <135/85 mmHg), hypertensive (home blood pressure 135/85-160/90 mmHg), and severely hypertensive (home blood pressure > or =160/90 mmHg). The mean plasma 8-isoprostane level in the severely hypertensive group (21.1+/-5.2 pg/ml) was significantly higher than that in the normotensive (20.2+/-4.9 pg/ml) or hypertensive (19.7+/-5.1 pg/ml) group, and this result was unchanged when we adjusted for possible confounding factors such as age, sex, use of vitamin A, C or E supplements, smoking status, drinking status, body mass index, use of non-steroidal anti-inflammatory drugs, history of diabetes, hypercholesterolemia, home heart rate and serum creatinine level. Thus, the level of plasma 8-isoprostane appears to be elevated in older subjects with severe hypertension.
Hozawa
Atsushi
A
Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan. hozawa@mail.tohoku.ac.jp
Ebihara
Satoru
S
Ohmori
Kaori
K
Kuriyama
Shinichi
S
Ugajin
Takashi
T
Koizumi
Yayoi
Y
Suzuki
Yoshinori
Y
Matsui
Toshifumi
T
Arai
Hiroyuki
H
Tsubono
Yoshitaka
Y
Sasaki
Hidetada
H
Tsuji
Ichiro
I
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007564:Japan; D008297:Male; D018384:Oxidative Stress; D012720:Severity of Illness Index; D014505:Urban Population
C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost