title: Warfarin reversal.
abstract: Warfarin is the most commonly used oral anticoagulant in the UK. It is associated with few side effects apart from haemorrhage. The most appropriate way to reverse the anticoagulant effect of warfarin depends on the clinical circumstances. In serious bleeding, rapid reversal is required, whereas in minor bleeding or asymptomatic over anticoagulation, a more leisurely approach is usually appropriate. This review discusses the current approaches to warfarin reversal in clinical practice. The development of a uniform approach to warfarin reversal in the Northern Region is described.
authors.affiliation: Department of Haematology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne UK. john.hanley@nuth.northy.nhs.uk
authors.forename: J P
authors.initials: JP
authors.lastname: Hanley
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D001777:Blood Coagulation / Q000502:physiology; D001779:Blood Coagulation Factors / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D003029:Coagulants / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005167:Factor VII / Q000627:therapeutic use; D015942:Factor VIIa; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced / Q000517:prevention & control; D010949:Plasma; D017410:Practice Guidelines as Topic; D011994:Recombinant Proteins / Q000627:therapeutic use; D014812:Vitamin K / Q000008:administration & dosage; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D001779:Blood Coagulation Factors; D003029:Coagulants; D011994:Recombinant Proteins; D014812:Vitamin K; C025667:prothrombin complex concentrates; D014859:Warfarin; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa