Synthesis of small molecule CDC25 phosphatases inhibitors.
A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.
Contour-Galcéra
Marie-Odile
MO
Ipsen Research Laboratories, Institut Henri Beaufour, 5, Avenue du Canada, F-91966 Les Ulis Cédex, France. m-odile.galcera.contour@ipsen.com
Lavergne
Olivier
O
Brezak
Marie-Christine
MC
Ducommun
Bernard
B
Prévost
Grégoire
G
D006801:Humans; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D011480:Protease Inhibitors; D020687:cdc25 Phosphatases