[Mechanism of spontaneous rupture of hepatocellular carcinoma].
OBJECTIVE
To study the mechanism of spontaneous rupture of hepatocellular carcinoma (HCC).


METHODS
The specimens of 30 patients with ruptured HCC and 30 patients with non-ruptured HCC were collected. Immunofluorescence, immunohistochemical and flow cytometry techniques were used to detect the phagocytosis of macrophages and the deposition of immune complex (IC) on vascular wall.


RESULTS
In this study, the poor function of macrophage phagocytosis was found in patients with ruptured HCC, which could results in the cumulating of IC and deposition on vascular wall. The IC, which composed of hepatitis B virus e1 antigen (HBeAg/1), complement C1q and immunoglobulins, was found deposited in the elastic membrane of arteries. Likely as a result of IC deposition, vascular injury occurs mainly in the small arteries where the deposition of IC was present. As the small arteries were the blood vessels with predominant injury, they would likely to be the ones to split and cause hemorrhage and rupture of HCC during vascular load increase.


CONCLUSIONS
We would conclude that the poor function of macrophage phagocytosis, which lead to the IC deposition and vascular injury may be the factors involved in the pathogenesis of ruptured HCC.
Zhu
Li-xin
LX
Department of Surgery, Anhui Medical University, Hefei 230022, China.
Geng
Xiao-ping
XP
Fan
Shang-da
SD
D000328:Adult; D000936:Antigen-Antibody Complex / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000276:immunology* / Q000473:pathology; D015922:Complement C1q / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006513:Hepatitis B e Antigens / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012422:Rupture, Spontaneous / Q000276:immunology
D000936:Antigen-Antibody Complex; D006513:Hepatitis B e Antigens; D007136:Immunoglobulins; D015922:Complement C1q