title: Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancer.
abstract: Tankyrase promotes telomere elongation by interaction with the telomeric protein binding factor TRF1, a negative regulator of telomere extension. We measured tankyrase mRNA by real-time RT-PCR in 66 breast cancers and in paired normal tissues. Results were compared with hTERT mRNA expression. The levels of tankyrase in breast cancers were significantly higher in comparison to normal tissues (P<0.0001) and significantly related to the status of progesterone receptors. No relationship was found between tankyrase and hTERT mRNA expression in breast cancers. According to our results, tankyrase expression appeared up regulated in breast cancers.
authors.affiliation: Clinical Biochemistry Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Gelmini
authors.forename: Melissa
authors.initials: M
authors.lastname: Poggesi
authors.forename: Vito
authors.initials: V
authors.lastname: Distante
authors.forename: Simonetta
authors.initials: S
authors.lastname: Bianchi
authors.forename: Lisa
authors.initials: L
authors.lastname: Simi
authors.forename: Michaela
authors.initials: M
authors.lastname: Luconi
authors.forename: Claudia Casini
authors.initials: CC
authors.lastname: Raggi
authors.forename: Luigi
authors.initials: L
authors.lastname: Cataliotti
authors.forename: Mario
authors.initials: M
authors.lastname: Pazzagli
authors.forename: Claudio
authors.initials: C
authors.lastname: Orlando
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins; D011980:Receptors, Progesterone; D020133:Reverse Transcriptase Polymerase Chain Reaction; D038501:Tankyrases / Q000096:biosynthesis*; D019098:Telomerase / Q000096:biosynthesis; D014407:Tumor Cells, Cultured
chemical_list: D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D011980:Receptors, Progesterone; D038501:Tankyrases; D019098:Telomerase; C418109:TNKS protein, human