Infection prophylaxis of gunshot wounds using probiotics.
OBJECTIVE
To report a new method of surgical infection prophylaxis for postoperative gunshot wounds to the extremities.


METHODS
Gunshot wounded animals were divided into three groups: treatment (probiotic Sporobacterin), antibiotic (cephalosporin cefamezin) and control (no treatment). Histological studies of wound-bed tissue were taken on days 1, 3, 5 and 10 of the study.


RESULTS
The probiotic administered per os was more effective than antibiotics for prophylaxis of surgical infection.


CONCLUSIONS
The probiotic's effect is based on the natural defence mechanism activated after injury--the bacterial translocation of saprophytic bacteria from the gut to the wound.


BACKGROUND
None.
Nikitenko
V I
VI
Department of Trauma Surgery, Orthopaedics and Military Surgery, Orenburg State Medical Academy, Russia. bacoren@rambler.ru
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001412:Bacillus subtilis / Q000502:physiology*; D018988:Bacterial Translocation / Q000187:drug effects; D001428:Bacterial Vaccines / Q000494:pharmacology / Q000627:therapeutic use*; D002437:Cefazolin / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D017053:Infection Control / Q000379:methods; D007273:Injections, Intramuscular; D019936:Probiotics / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D011897:Random Allocation; D016037:Single-Blind Method; D013530:Surgical Wound Infection / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007507:Therapeutic Irrigation; D016896:Treatment Outcome; D014948:Wounds, Gunshot / Q000601:surgery*
D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines; D002511:Cephalosporins; C495704:sporobacterin; D002437:Cefazolin