title: Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia.
abstract: OBJECTIVE
  To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions.
  
  
  METHODS
  Prospective and retrospective observational study.
  
  
  METHODS
  Dermatology outpatient clinic in a general hospital.
  
  
  METHODS
  Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period.
  
  
  METHODS
  None.
  
  
  METHODS
  Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing.
  
  
  RESULTS
  HLA-DR4 (DRB1*0404) was significantly increased (P<.001; odds ratio, 3.9; 95% confidence interval, 1.86-8.03). Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32.
  
  
  CONCLUSIONS
  The HLA-DRB1*0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.
authors.affiliation: Department of Dermatology, Hospital General Dr Manuel Gea González, Tlalpan, México.
authors.forename: Cristina
authors.initials: C
authors.lastname: García-Corona
authors.forename: Elisa
authors.initials: E
authors.lastname: Vega-Memije
authors.forename: Adalberto
authors.initials: A
authors.lastname: Mosqueda-Taylor
authors.forename: Jesús K
authors.initials: JK
authors.lastname: Yamamoto-Furusho
authors.forename: Alma A
authors.initials: AA
authors.lastname: Rodríguez-Carreón
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Ruiz-Morales
authors.forename: Norma
authors.initials: N
authors.lastname: Salgado
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000453:epidemiology* / Q000821:virology*; D005787:Gene Frequency; D015804:HLA-DR4 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012189:Retrospective Studies; D044465:White People / Q000235:genetics
chemical_list: D004279:DNA, Viral; D015804:HLA-DR4 Antigen