The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors.
Fürstner
Alois
A
Max-Planck-Institut für Kohlenforschung, 45470 Mülheim/Ruhr, Germany. fuerstner@mpi.muelheim.mpg.de
Reinecke
Kerstin
K
Prinz
Heino
H
Waldmann
Herbert
H
D000470:Alkaloids / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011353:Prodigiosin / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D011758:Pyrroles / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology
D000470:Alkaloids; D004791:Enzyme Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D011758:Pyrroles; C408872:roseophilin; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases; D011353:Prodigiosin