Flecainide and propafenone induced ST-segment elevation in patients with atrial fibrillation: clue to specificity of Brugada-type electrocardiographic changes.
Potent sodium channel, blockade with type IC antiarrhythmics can provoke characteristic electrocardiographic changes consistent with Brugada's syndrome in unselected patients with atrial fibrillation. In 176 treated patients, the incidence of the characteristic abnormality is small (2.3%), and thus although no ventricular arrhythmia events were observed during follow-up, the long-term clinical significance in a larger patient cohort remains to be determined. These data provide insight into the specificity of the response to type I drug administration in patients suspected of having Brugada's syndrome.
Beldner
Stuart
S
Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Lin
David
D
Marchlinski
Francis E
FE
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D002037:Bundle-Branch Block / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005424:Flecainide / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D011405:Propafenone / Q000008:administration & dosage / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D013997:Time Factors; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D011405:Propafenone; D005424:Flecainide