title: RNA and microRNAs in fragile X mental retardation.
abstract: Fragile X syndrome is caused by the loss of an RNA-binding protein called FMRP (for fragile X mental retardation protein). FMRP seems to influence synaptic plasticity through its role in mRNA transport and translational regulation. Recent advances include the identification of mRNA ligands, FMRP-mediated mRNA transport and the neuronal consequence of FMRP deficiency. FMRP was also recently linked to the microRNA pathway. These advances provide mechanistic insight into this disorder, and into learning and memory in general.
authors.affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Jin
authors.forename: Reid S
authors.initials: RS
authors.lastname: Alisch
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Warren
mesh_terms: D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D014176:Protein Biosynthesis; D012313:RNA / Q000502:physiology*; D018911:Trinucleotide Repeats
chemical_list: D035683:MicroRNAs; D012313:RNA