title: The lesional skin of linear IgA bullous dermatosis expresses growth-regulated peptide (GRO)-alpha.
abstract: The patient was a 62-year-old man with erythema with tense vesiculobullae and erosions on the bilateral elbows, right knee, and one buttock. A skin biopsy specimen revealed subepidermal blister formation with a predominant infiltration of neutrophils and papillary neutrophilic microabscesses. Direct immunofluorescence study showed linear deposition of IgA and weak deposition of IgG at the basement membrane zone of the lesional skin, and indirect immunofluorescence study showed linear deposition of IgA at the epidermal side of the 1M NaCl-separated normal skin. He was diagnosed with linear IgA bullous dermatosis. Immunohistochemical study revealed that the lesional and perilesional keratinocytes expressed growth-regulated peptide (GRO) -alpha, a potent chemoattractant for neutrophils. This suggests that GRO-alpha plays a role in the infiltration of neutrophils into the lesional skin and in bulla formation in linear IgA bullous dermatosis.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tsunemi
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ihn
authors.forename: Hidehisa
authors.initials: H
authors.lastname: Saeki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D054360:Chemokine CXCL1; D019743:Chemokines, CXC / Q000378:metabolism*; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration / Q000235:genetics*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology* / Q000473:pathology*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D036341:Intercellular Signaling Peptides and Proteins