Changes in the steady-state potential in rats with focal cerebral ischemia receiving cyclopentyladenosine.
Brain function and neuroprotective activity of cyclopentyladenosine in rats with focal cerebral ischemia were evaluated by recording the steady-state potential. Cerebral ischemia was modeled by intravasal occlusion of the left internal carotid and middle cerebral arteries and bilateral occlusion of the common carotid arteries. Recording of the steady-state brain potential during experimental ischemia allowed identifying the development of ischemic depolarization by a negative potential shift. Changes in the steady-state potential after cyclopentyladenosine administration reflected delayed development of ischemic depolarization in the nervous tissue. Cyclopentyladenosine holds much promise for the protection of nerve cells from ischemic injury.
Sufianova
G Z
GZ
Department of Pharmacology, Irkutsk State Medical University. neuro@medk.baikal.ru
Murik
S E
SE
Usov
L A
LA
Sufianov
A A
AA
Shapkin
A G
AG
Taborov
M V
MV
D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000241:Adenosine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D008297:Male; D008839:Microelectrodes; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology; D051381:Rats; D013997:Time Factors
D018696:Neuroprotective Agents; D000241:Adenosine