Helicobacter pylori: recombination, population structure and human migrations.
Helicobacter pylori shows extensive genetic diversity and variability due to frequent intraspecific recombination during mixed infection. In the last years, modern genetic and genomic technology as well as cutting-edge population genetic analysis have been used to investigate the population structure and genetic variability of this pathogen. This review article summarizes recent developments in this rapidly moving field.
Suerbaum
Sebastian
S
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl-Neuberg-Str 1, D-30625 Hannover, Germany. suerbaum.sebastian@mh-hannover.de
Achtman
Mark
M
D017753:Ecosystem; D004641:Emigration and Immigration; D014644:Genetic Variation; D016680:Genome, Bacterial; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D017720:Molecular Epidemiology; D011157:Population Dynamics; D011995:Recombination, Genetic