Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy.
Although the safety profiles of coronary stents eluting sirolimus or paclitaxel do not seem to differ from those of bare metal stents in the short-to-medium term, concern has arisen about the potential for late stent thromboses related to delayed endothelialisation of the stent struts. We report four cases of angiographically-confirmed stent thrombosis that occurred late after elective implantation of polymer-based paxlitaxel-eluting (343 and 442 days) or sirolimus-eluting (335 and 375 days) stents, and resulted in myocardial infarction. All cases arose soon after antiplatelet therapy was interrupted. If confirmed in systematic long-term follow-up studies, our findings have potentially serious clinical implications.
McFadden
Eugène P
EP
Thoraxcenter, Erasmus University, Rotterdam, Netherlands.
Stabile
Eugenio
E
Regar
Evelyn
E
Cheneau
Edouard
E
Ong
Andrew T L
AT
Kinnaird
Timothy
T
Suddath
William O
WO
Weissman
Neil J
NJ
Torguson
Rebecca
R
Kent
Kenneth M
KM
Pichard
August D
AD
Satler
Lowell F
LF
Waksman
Ron
R
Serruys
Patrick W
PW
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000628:therapy; D003328:Coronary Thrombosis / Q000209:etiology*; D003331:Coronary Vessels; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D017239:Paclitaxel / Q000008:administration & dosage*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents / Q000009:adverse effects*
D010975:Platelet Aggregation Inhibitors; D017239:Paclitaxel; D020123:Sirolimus