Synthesis of the tubuvaline-tubuphenylalanine (Tuv-Tup) fragment of tubulysin.
[structure: see text] Advanced intermediates and analogues of tubulysins were prepared in a convergent strategy.
Wipf
Peter
P
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
Takada
Takeshi
T
Rishel
Michael J
MJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010446:Peptide Fragments / Q000138:chemical synthesis; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry*; D013237:Stereoisomerism; D014633:Valine / Q000031:analogs & derivatives / Q000737:chemistry*
D000970:Antineoplastic Agents; D009842:Oligopeptides; D010446:Peptide Fragments; C502386:tubulysin D; D010649:Phenylalanine; D014633:Valine