Acute neuropathy mimicking porphyria induced by aminolevulinic acid during photodynamic therapy.
An 82-year-old man developed severe, acute, predominantly motor polyneuropathy, signs of autonomic involvement, and skin changes following aminolevulinic acid (ALA) administration. The compound was used as a prodrug for photodynamic therapy of Barrett's esophagitis. Changes were observed in various parameters of the heme pathway. The case reported represents a rare response to ALA treatment, resembling an acute attack of hepatic porphyria with neurological features.
Sylantiev
Constantin
C
Department of Neurology, Tel Aviv Sourasky Medical Center, 6, Weizman Street, Tel Aviv 642 39, Israel.
Schoenfeld
Nili
N
Mamet
Rivka
R
Groozman
Galina B
GB
Drory
Vivian E
VE
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000009:adverse effects*; D001471:Barrett Esophagus / Q000188:drug therapy; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D010778:Photochemotherapy / Q000009:adverse effects*; D017319:Photosensitizing Agents / Q000009:adverse effects*; D011164:Porphyrias / Q000175:diagnosis*
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid