title: Cytoreductive surgery and intraperitoneal chemotherapy for pseudomyxoma peritonei.
abstract: OBJECTIVE
  Surgical improvement can be achieved in selected patients with pseudomyxoma peritonei (PMP) by major cytoreductive surgery and intraperitoneal chemotherapy (IPEC). The purpose of this retrospective study was to analyze morbidity, mortality, and survival following therapy.
  
  
  METHODS
  Between July 1995 and September 2003, 28 patients (mean age 56 years, range 28-79) with PMP were operated on with the aim of complete macroscopical cytoreduction. Surgery was followed by IPEC.
  
  
  RESULTS
  A macroscopically complete cytoreduction was achieved in 11 patients (40%). The mean operating time was 6 h with a mean of three peritonectomy procedures per patient. Cisplatin (15 out of 28), mitomycin C (6 out of 28) and 5-FU (7 out of 28) were used for the intraoperative chemotherapy. Overall morbidity was 36%. Most frequent surgical complications were digestive fistulae (3 out of 28), abscesses (5 out of 28) and bleeding (2 out of 28). Two patients died postoperatively. Patients with low tumor volume (mean survival time 78+/-11 vs. 37+/-9 months, p=0.05) and complete cytoreduction (73+/-10 vs. 24+/-8 months, p<0.05) had an improved prognosis.
  
  
  CONCLUSIONS
  Cytoreductive surgery combined with IPEC is associated with acceptable morbidity and mortality. Complete cytoreduction may improve survival, particularly in selected patients with PMP who have a low tumor volume, complete cytoreduction, and no organ metastases.
authors.affiliation: Department for Visceral and Transplant Surgery, Medical School of Hannover, 30623 Hannover, Germany.
authors.forename: Z
authors.initials: Z
authors.lastname: Güner
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
authors.forename: M H
authors.initials: MH
authors.lastname: Dahlke
authors.forename: H J
authors.initials: HJ
authors.lastname: Schlitt
authors.forename: J
authors.initials: J
authors.lastname: Klempnauer
authors.forename: P
authors.initials: P
authors.lastname: Piso
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D013505:Digestive System Surgical Procedures / Q000379:methods*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D011379:Prognosis; D011553:Pseudomyxoma Peritonei / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil