[Ageing and necrotic form of "unwanted" cells].
Collecting experimental data testify that cellular necrosis is the same component of "unwanted" cell system elimination in a metaphyte, as well as apoptosis. The essential role of the last in definition of rates of ageing is expressed, in particular, in secretion by phagocytes of the factors overwhelming inflammatory reactions which are rather characteristic for such illnesses as an atherosclerosis, a diabetes and others. Apparently, infringement of balance between necrotic and apoptotic forms "unwanted" cell elimination from an organism can be the important factor of ageing and the reason of reduction of life expectancy as a result of supression of renewal processes in an organism, occurrence and weights of development of some senile illness.
Proskuriakov
S Ia
SIa
Konopliannikov
A G
AG
D000818:Animals; D017209:Apoptosis; D001161:Arteriosclerosis / Q000209:etiology; D016922:Cellular Senescence; D003920:Diabetes Mellitus / Q000209:etiology; D006803:Human Development; D006801:Humans; D008017:Life Expectancy; D009024:Morphogenesis; D009336:Necrosis; D010586:Phagocytes / Q000502:physiology; D010587:Phagocytosis / Q000502:physiology