title: The management of pain in arthritis and the use of cyclooxygenase-2 inhibitors: new paradigms and insights.
abstract: Chronic pain from arthritis has been one of the biggest causes of disability and loss of function in the United States. This is still the case despite many new insights into the pathophysiology of pain, effective treatment approaches, and new safer medications that can be used for long-term use. There are many different types of arthritic problems. New disease- modifying agents that are available for some of these types of arthritic diseases such as rheumatoid arthritis have the potential to have a substantial impact on improvement in the long-term prognosis. Despite this optimistic outlook, pain often is a significant problem and should be treated whenever it becomes a barrier to function.
authors.affiliation: Pain Management Center, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. elross@partners.org.
authors.forename: Edgar
authors.initials: E
authors.lastname: Ross
mesh_terms: D000223:Adaptation, Psychological; D000700:Analgesics / Q000627:therapeutic use; D001168:Arthritis / Q000145:classification / Q000150:complications*; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007270:Injections, Intra-Articular; D007527:Isoenzymes / Q000378:metabolism*; D008565:Membrane Proteins; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010353:Patient Education as Topic; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011613:Psychotherapy
chemical_list: D000700:Analgesics; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases