title: Combined large cell neuroendocrine carcinoma.
abstract: We report a case of combined large cell neuroendocrine carcinoma. A 78-year-old man with vertigo was referred to our hospital where chest X-ray revealed a tumor shadow in the right lung. A transbronchial lung biopsy specimen verified a diagnosis of non-small cell lung carcinoma (cT1N0M0). Right lower lobectomy with mediastinal lymph node dissection (#7, 8, 9) was performed. A postoperative histological diagnosis was combined large cell neuroendocrine carcinoma of a component of squamous cell carcinoma [pT4 (pm) N2M0]. The patient received concurrent chemoradiotherapy due to upper mediastinal lymph node metastasis 4 months after surgery. The chemoradiotherapy well responded and the patient remains well 9 months after surgery.
authors.affiliation: Department of Surgery, Wakayama National Hospital, Wakayama, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Bessho
authors.forename: Keiya
authors.initials: K
authors.lastname: Yokochi
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Sakurai
mesh_terms: D000368:Aged; D018287:Carcinoma, Large Cell / Q000473:pathology* / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D011013:Pneumonectomy / Q000379:methods; D016896:Treatment Outcome