Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
Nine monotetrahydrofuranic Annonaceous acetogenins, montalicins A-E (1-5), cis-annoreticuin (6), montalicins F (7), I (8), and J (9), along with eight known acetogenins 10-17, were isolated from the seeds of Annona montana by a high performance liquid chromatographic (HPLC) method. The structures of all new isolates were elucidated and characterized by spectroscopic and chemical methods. These monotetrahydrofuranic Annonaceous acetogenins showed selectively potent cytotoxicity against two human cancer cell lines, 1A9 and Hep G2.
Liaw
Chih-Chuang
CC
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chang
Fang-Rong
FR
Wu
Chin-Chung
CC
Chen
Shu-Li
SL
Bastow
Kenneth F
KF
Hayashi
Ken-ichiro
K
Nozaki
Hiroshi
H
Lee
Kuo-Hsiung
KH
Wu
Yang-Chang
YC
D054378:Acetogenins; D031041:Annona; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005663:Furans / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007783:Lactones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012639:Seeds; D013329:Structure-Activity Relationship
D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; D005663:Furans; D007783:Lactones; D010936:Plant Extracts