Proportion of drug-related serious rare blood dyscrasias: estimates from the Berlin Case-Control Surveillance Study.
Drugs are an important cause of serious rare blood dyscrasias. To estimate the proportion of drug-related cases, we used data from the ongoing Berlin Case-Control Surveillance Study. The analysis included a total of 171 cases. The number of cases in which a drug etiology was assessed as at least "possible" was n = 29 (97%) for acute agranulocytosis, n = 4 (0.21%) for aplastic anemia, n = 8 (26%) for immune hemolytic anemia, n = 20 (25%) for immune thrombocytopenia, and n = 2 (20%) for thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. Our analysis suggests that a substantial fraction of blood dyscrasias may be attributable to drug therapy.
Andersohn
Frank
F
Institute of Clinical Pharmacology, Charité-University Medicine Berlin, Campus Charité Mitte, Berlin, Germany.
Bronder
Elisabeth
E
Klimpel
Andreas
A
Garbe
Edeltraut
E
D016907:Adverse Drug Reaction Reporting Systems; D001604:Berlin / Q000453:epidemiology; D016022:Case-Control Studies; D006402:Hematologic Diseases / Q000139:chemically induced* / Q000145:classification / Q000453:epidemiology*; D006801:Humans; D011159:Population Surveillance