Comparative study of enamel matrix derivative with or without GTR in the treatment of class II furcation lesions in dogs.
Chronic Class II furcation lesions were created in four dogs. After 21 days, group I remained as a control, group 2 was treated with membranes and enamel matrix derivative (EMD), and group 3 received EMD alone. Healing in group 1 was characterized by a long junctional epithelium and discrete bone formation; group 2 showed reduced bone formation; and group 3 showed significant bone regeneration (area of new bone = 67.36%+/-3.93%; distance from furcation roof to bone crest = 0.57+/-0.15 mm). The EMD led to significant regeneration of the furcation lesions, and the association with membranes was detrimental.
Regazzini
Plinio Fo
PF
Department of Oral and Maxillofacial Surgery and Traumatology and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil.
Novaes
Arthur B
AB
de Oliveira
Paulo T
PT
Palioto
Daniela B
DB
Taba
Mário
M
de Souza
Sergio L S
SL
Grisi
Márcio F M
MF
D000818:Animals; D001641:Bicuspid / Q000473:pathology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D004285:Dogs; D004492:Edetic Acid / Q000627:therapeutic use; D004846:Epithelial Attachment / Q000473:pathology; D017823:Furcation Defects / Q000145:classification / Q000473:pathology / Q000601:surgery*; D048091:Guided Tissue Regeneration / Q000379:methods*; D008567:Membranes, Artificial; D010012:Osteogenesis / Q000502:physiology; D011138:Polytetrafluoroethylene; D013524:Surgical Flaps; D014945:Wound Healing / Q000502:physiology
D018786:Bone Substitutes; D002614:Chelating Agents; D003746:Dental Enamel Proteins; D008567:Membranes, Artificial; C109069:enamel matrix proteins; D011138:Polytetrafluoroethylene; D004492:Edetic Acid