4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials.
Supercritical CO2 selectively extracted a series of 4-alkyl and 4-phenyl 5,7-dihydroxycoumarins from Mesua ferrea blossoms. Chemical modifications of the isolated compounds allowed us to confirm the structures elucidated by spectroscopic means and to prepare new derivatives amenable to SAR studies and potential pharmaceutical development. Biological investigations towards the screening on a number of bacteria strains and Plasmodium falciparum, identified compounds 1-9 as weak antiprotozoal agents and potent antibacterials on resistant Gram-positive strains.
Verotta
Luisella
L
Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy. luisella.verotta@unimi.it
Lovaglio
Erminio
E
Vidari
Giovanni
G
Finzi
Paola Vita
PV
Neri
Maria Grazia
MG
Raimondi
Alessandro
A
Parapini
Silvia
S
Taramelli
Donatella
D
Riva
Antonella
A
Bombardelli
Ezio
E
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry*; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D035264:Flowers / Q000737:chemistry; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects
D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D003374:Coumarins