Hazelnut oil administration reduces aortic cholesterol accumulation and lipid peroxides in the plasma, liver, and aorta of rabbits fed a high-cholesterol diet.
Hazelnut oil (HO) is rich in monounsaturated fatty acids and antioxidants. We wanted to investigate the effect of HO on lipid levels and prooxidant-antioxidant status in rabbits fed a high-cholesterol (HC) diet. An HC diet caused significant increases in lipids and lipid peroxide levels in the plasma, liver, and aorta together with histopathological atherosclerotic changes in the aorta. Glutathione levels, glutathione peroxidase, and glutathione transferase activities decreased significantly, but superoxide dismutase activity and vitamin E and C levels remained unchanged in the livers of rabbits following HC diet. HO supplementation reduced plasma, liver, and aorta lipid peroxide levels and aorta cholesterol levels together with amelioration in atherosclerotic lesions in the aortas of rabbits fed an HC diet, without any decreasing effect on cholesterol levels in the plasma or liver. HO did not alter the antioxidant system in the liver in the HC group. Our findings indicate that HO reduced oxidative stress and cholesterol accumulation in the aortas of rabbits fed an HC diet.
Hatipoğlu
Aydan
A
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, 34093 Capa-Istanbul, Turkey.
Kanbağli
Oznur
O
Balkan
Jale
J
Küçük
Mutlu
M
Cevikbaş
Uğur
U
Aykaç-Toker
Gülçin
G
Berkkan
Hakan
H
Uysal
Müjdat
M
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D001161:Arteriosclerosis / Q000188:drug therapy / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D031211:Corylus / Q000737:chemistry*; D004036:Diet, Atherogenic; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D000975:Antioxidants; D008054:Lipid Peroxides; D010938:Plant Oils; D014810:Vitamin E; D002784:Cholesterol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione