title: [HPLC determination of diperodon enantiomers in blood serum by using teicoplanin chiral stationary phase].
abstract: The chiral stationary phase on the base of teicoplanin and the polar-organic mobile phase methanol/acetonitrile/acetic acid/triethylamine 45/55/0.3/0.2 was used for the separation of diperodon enantiomers. The developed method was suitable to determine the enantiomers in blood serum up to 0.5 microg/ml. The degradation of diperodon enantiomers was studied in serum by an in vitro method and the experimental rate constants were determined.
authors.affiliation: Katedra analytickej chémie, Fakulty chemickej a potravinárskej chémie, Slovenskej technickej univerzity, Bratislava.
authors.forename: K
authors.initials: K
authors.lastname: Hrobonová
authors.forename: J
authors.initials: J
authors.lastname: Lehotay
authors.forename: J
authors.initials: J
authors.lastname: Cizmárik
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D010880:Piperidines / Q000097:blood* / Q000737:chemistry; D013237:Stereoisomerism; D017334:Teicoplanin
chemical_list: D010880:Piperidines; C027013:diperodon; D017334:Teicoplanin