Dimerization of alpha1-adrenoceptors.
Three distinct genes encode alpha(1)-adrenoceptors. Although homodimers of each subtype have been reported, certain but not all combinations of heterodimers of the alpha(1)-adrenoceptors appear to form. Key studies in this field are reviewed and the approaches that have been applied to monitoring the selectivity and the basis of alpha(1)-adrenoceptor dimerization are discussed.
Milligan
G
G
Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. g.milligan@bio.gla.ac.uk
Pediani
J
J
Fidock
M
M
López-Giménez
J F
JF
D000818:Animals; D004247:DNA / Q000737:chemistry; D018076:DNA, Complementary / Q000378:metabolism; D019281:Dimerization; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D018340:Receptors, Adrenergic, alpha-1 / Q000737:chemistry*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry*; D013329:Structure-Activity Relationship
D018076:DNA, Complementary; D008024:Ligands; D018340:Receptors, Adrenergic, alpha-1; D043562:Receptors, G-Protein-Coupled; D004247:DNA