Synthesis of polysubstituted 4-fluoroquinolinones.
[reaction: see text] A convenient one-pot synthesis of 4-fluoroquinolinones that are active against KDR kinase is described. The mechanism of the reaction is believed to involve the formation of a quinone methide intermediate.
Kiselyov
Alexander S
AS
Department of Chemistry, ImClone Systems, 180 Varick Street, 6th Floor, New York, New York 10014, USA.
Piatnitski
Evgueni L
EL
Doody
Jacqueline
J