title: Computational models of hair cell bundle mechanics: I. Single stereocilium.
abstract: A distributed parameter model for describing the response of a stereocilium to an applied force is presented. This model is based on elasticity theory, plus the geometry and material properties of the stereocilium. The stereocilia shaft above the taper is not assumed to be perfectly rigid. It is assumed to be deformable and that two separate mechanisms are involved in its deformation: bending and shear. The influence of each mode of deformation is explored in parametric studies. Results show that the magnitude of tip deflection depends on the shear compliance of the stereocilium material, the degree of base taper, and stereocilium height. Furthermore, the deformation profiles observed experimentally will occur only if there are constraints on the geometry and material properties of the stereocilium.
authors.affiliation: Department of Engineering Science and Mechanics and School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Mail Code 0219, Blacksburg, VA 24061, USA.
authors.forename: John
authors.initials: J
authors.lastname: Cotton
authors.forename: Wally
authors.initials: W
authors.lastname: Grant
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D006198:Hair Cells, Auditory / Q000502:physiology*; D006801:Humans; D008432:Mathematical Computing; D008954:Models, Biological