title: Effect of previous hormone replacement therapy on endometrial polyps during menopause.
abstract: The aim of this study was to evaluate the effect of hormone replacement therapy (HRT) on the expression of Ki-67, bcl-2 and c-erb.B2 in endometrial polyps during menopause. Sixteen patients using HRT and 24 untreated controls with endometrial polyps were enrolled in this study. Polypectomy was carried out by hysteroscopy. The presence of c-erb.B2, bcl-2 and Ki-67 expression was determined by immunohistochemistry. HRT was found to decrease Ki-67 and bcl-2 expression in endometrial polyps without affecting the c-erb.B2 staining reaction. HRT may cause endometrial polyp involution by decreasing proliferation and stimulating apoptosis.
authors.affiliation: Ceparh, Salvador, Bahia, Brazil.
authors.forename: H
authors.initials: H
authors.lastname: Maia
authors.forename: A
authors.initials: A
authors.lastname: Maltez
authors.forename: E
authors.initials: E
authors.lastname: Studard
authors.forename: C
authors.initials: C
authors.lastname: Athayde
authors.forename: E M
authors.initials: EM
authors.lastname: Coutinho
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000368:Aged; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D015914:Estrogen Replacement Therapy; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology; D008593:Menopause; D008875:Middle Aged; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077563:Norethindrone Acetate; D011127:Polyps / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D004958:Estradiol; D004966:Estrogens, Conjugated (USP); D019394:Ki-67 Antigen; D017258:Medroxyprogesterone Acetate; D009640:Norethindrone; D000077563:Norethindrone Acetate; D019253:Proto-Oncogene Proteins c-bcl-2; D018719:Erb-b2 Receptor Tyrosine Kinases