title: Successful treatment of pulmonary mucormycosis in an allogenic bone-marrow transplant recipient with combined medical and surgical therapy.
abstract: Mucormycosis is a rare, but severe, complication in allogenic bone-marrow recipients with a mortality rate of about 80%. Moreover, its incidence appears to have increased within the last decade. We report a case of pulmonary and nasal mucormycosis in a 55-y-old patient, which occurred 1 y after BMT. Treatment combining 4 months of amphotericin B, early surgical resection of infected tissue and discontinuation of immunosuppressive treatment allowed the cure of this mould infection.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Paris, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Pavie
authors.forename: Matthieu
authors.initials: M
authors.lastname: Lafaurie
authors.forename: Claire
authors.initials: C
authors.lastname: Lacroix
authors.forename: Anne
authors.initials: A
authors.lastname: Marie Zagdanski
authors.forename: Denis
authors.initials: D
authors.lastname: Debrosse
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
authors.forename: Francis
authors.initials: F
authors.lastname: Derouin
authors.forename: Eliane
authors.initials: E
authors.lastname: Gluckman
authors.forename: Jean
authors.initials: J
authors.lastname: Michel Molina
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000628:therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014184:Transplantation, Homologous / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000666:Amphotericin B