title: Determinants of dynamic hyperinflation in a bench model.
abstract: BACKGROUND
  Previous in vivo data suggest that high airway resistance (R(aw)) promotes dynamic hyperinflation, especially when coupled to high minute ventilation (V(E)). However, no studies have systematically examined the relative effects of various mechanical parameters on dynamic hyperinflation.
  
  
  METHODS
  Intrinsic positive end-expiratory pressure (PEEPi) was measured with a ventilator-lung model, over a range and various permutations of R(aw), V(E), respiratory system compliance (C(RS)), and duty cycles/flow regimes.
  
  
  RESULTS
  Substantial dynamic hyperinflation (PEEPi > 5 cm H(2)O occurred at various V(E), even when R(aw) was low (4 cm H(2)O/L/s) or just above normal (18 cm H(2)O/L/s). A V(E) > or = 15 L/min was associated with increasing PEEPi in this model, across a broad range of mechanical permutations. PEEPi was significantly higher in all models during descending ramp flow than during constant flow, at equivalent peak flows (wherein duty cycle during descending ramp flow was twice that of constant flow). PEEPi was equivalent when duty cycles (and all other mechanical parameters) were equal. PEEPi was significantly greater, irrespective of duty cycle, R(aw), and C(RS), when delivered with lower tidal volume (0.6 L vs 1.0 L). The change in peak airway pressure associated with development of dynamic hyperinflation was consistently greater than the observed PEEPi. Higher V(E), resistance, compliance, and duty cycles were all independently associated with dynamic hyperinflation.
  
  
  CONCLUSIONS
  In this bench model, dynamic hyperinflation occurred with high V(E), even at low R(aw). Since moderate R(aw) and V(E) frequently occur in vivo, even without obstructive lung disease, occult dynamic hyperinflation is likely to occur commonly. PEEPi was greater with high frequency and small tidal volume (0.6 L) than with equal V(E) of lower frequency and larger tidal volume (1.0 L).
authors.affiliation: Department of Pulmonary and Critical Care, Bridgeport Hospital, Yale University School of Medicine, CT 06610, USA.
authors.forename: Natalya Y
authors.initials: NY
authors.lastname: Thorevska
authors.forename: Constantine A
authors.initials: CA
authors.lastname: Manthous
mesh_terms: D004867:Equipment Design; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D066298:In Vitro Techniques; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008176:Lung Volume Measurements; D018467:Positive-Pressure Respiration, Intrinsic / Q000175:diagnosis*; D012129:Respiratory Function Tests