title: [Clinical and mycological examinations of oral mucosa in cyclosporine A treated patients after renal transplantation].
abstract: Cyclosporine A (CsA) is one of the basic and often used immunosuppressive agents. It is used to prevent rejection of allogenic transplants and to cure many diseases with autoimmunological components. The development of transplantology and frequent presence of autoaggressive disorders causes increased use of CsA, which intensifies problem of side-effects. Gingival overgrowth, oral mucosa pathologies related with bacterial, viral and fungal infections and neoplasma are described as most frequent side-effects of cyclosporine A in the oral cavity. The aim of this study was to assess the frequency of presence of different types of oral mucosa lesions in cyclosporine A-treated patients after renal transplantation. Thirty renal transplant recipients aged 11-64 years (including 13 females and 17 males) with cyclosporine treatment period from 6 months to 10 years were examined. Pathological changes on the oral mucosa were noted in 18 patients (60%). The fungal infections were the most often observed pathology (46.7% of examined persons). In mycological tests Candida albicans was most often isolated. Other species: C. kefyr, C. parapsilosis and C. tropicalis were also found. In 4 cases cheilitis angularis was additionally diagnosed. In 16.7% of CsA-treated patients, pathological changes of epithelium with homogenic leucoplakia features were observed. Hypertrophic lesions of oral mucosa in 10% of cases and many small erosions of inflamed mucosa of hard palate in 1 case were also noted. Our observations show connection between incidence of oral mucosa pathologies and immunosuppressive treatment. This suggests that interdisciplinary cooperation is necessary for early start of prevention and treatment program.
authors.affiliation: Zakład Periodontologii i Chorób, Błony Sluzowej Jamy Ustnej, Akademia Medyczna w Gdańsku.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Tyrzyk
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Sadlak-Nowicka
authors.forename: Anna
authors.initials: A
authors.lastname: Kedzia
authors.forename: Mariusz
authors.initials: M
authors.lastname: Bochniak
authors.forename: Beata
authors.initials: B
authors.lastname: Szumska-Tyrzyk
authors.forename: Przemysław
authors.initials: P
authors.lastname: Rutkowski
mesh_terms: D000293:Adolescent; D000328:Adult; D002177:Candidiasis / Q000209:etiology; D002613:Cheilitis / Q000209:etiology; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D019214:Gingival Overgrowth / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D007971:Leukoplakia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects / Q000382:microbiology / Q000473:pathology / Q000821:virology
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine