title: Jayjock and Lewis reply.
abstract: The current state-of-the-science, in our opinion, is incapable of accurately predicting the human health risk at environmental exposures to chemicals. We believe that dose-response models represent an integral part of the scientific method but that all models require valid scientific data in the realm of actual exposure in order to be derived and function properly. Given this current state, the evidence to date and the promise of hormesis to provide a detectable signal at low-dose, we view it as a variable and valuable hypothesis worthy of significant scientific effort.
authors.affiliation: Rohm and Haas Company, Spring House, Pennsylvania 19477, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Jayjock
authors.forename: P G
authors.initials: PG
authors.lastname: Lewis
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019055:No-Observed-Adverse-Effect Level; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health; D018570:Risk Assessment / Q000379:methods; D018675:Toxicity Tests