MPC1001 and its analogues: new antitumor agents from the fungus Cladorrhinum species.
[structure: see text] Eight new compounds, MPC1001 and MPC1001B-H, were isolated from the fungus Cladorrhinum sp. KY4922. Multiple NMR experiments and CD data revealed MPC1001 to be an O-methyl derivative of emestrin, a 15-membered antifungal antibiotic containing a unique epidithiodioxopiperazine skeleton. Other compounds were elucidated to be structurally related novel analogues. MPC1001 and the analogues exerted potent antiproliferative activities against a human tumor cell line.
Onodera
Hideyuki
H
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahimachi, Machida, Tokyo 194-8533, Japan. hideyuki.onodera@kyowa.co.jp
Hasegawa
Atsuhiro
A
Tsumagari
Noriko
N
Nakai
Ryuichiro
R
Ogawa
Tatsuhiro
T
Kanda
Yutaka
Y
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry; D020037:Sordariales / Q000737:chemistry*
D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C493112:MPC1001; D010879:Piperazines