Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells.
A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E(2) production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.
Park
Eun-Jung
EJ
College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea.
Min
Hye-Young
HY
Ahn
Yong-Hyun
YH
Bae
Cheol-Man
CM
Pyee
Jae-Ho
JH
Lee
Sang Kook
SK
D000818:Animals; D002460:Cell Line; D015232:Dinoprostone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000094162:Phytoalexins
D015232:Dinoprostone; D008070:Lipopolysaccharides; D013267:Stilbenes; C049032:pinosylvin; D000094162:Phytoalexins