title: [Acute intoxication with fenspiride].
abstract: According to the best of our knowledge this is the first publication in medical literature about the acute intoxication with fenspiride. The two cases of a young female patients, intoxicated with Eurespal, were described. The orthostatic hypotonia with the blood pressure about 105-115/70 mm Hg in the horizontal position and 70-80/40 mm Hg in the sitting position was dominating. The heart rate was 100-110/min. when lying and 130-140/min. when sitting. The main symptoms were probably caused by inhibition of alpha1 adrenergic receptors.
  
  
  CONCLUSIONS
  Main clinical manifestations make us reconsider the opinion about safety of fenspiride especially after acute intoxication.
authors.affiliation: I Klinika Chorób Wewnetrznych i Ostrych Zatruć, Akademii Medycznej w Gdańsku. jsanand@amedec.amg.gda.pl
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Chodorowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Sein Anand
authors.forename: Roman
authors.initials: R
authors.lastname: Korolkiewicz
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D058668:Adrenergic alpha-1 Receptor Antagonists; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced*; D011187:Posture; D013141:Spiro Compounds / Q000506:poisoning*; D013610:Tachycardia / Q000139:chemically induced*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013141:Spiro Compounds; C084775:fenspiride