A novel antimicrobial indolizinium alkaloid from Aniba panurensis.
Activity-guided fractionation of an Aniba panurensis organic solvent extract has led to the isolation of the novel alkaloid 6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, as the trifluoroacetic acid salt (1). Its structure was determined by NMR and mass spectrometry. Bioassays performed in vitro demonstrated toxicity of compound 1 to a drug-resistant strain of Candida albicans.
Klausmeyer
Paul
P
Natural Products Support Group, Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc, National Cancer Institute-Frederick, Maryland 21702-1201, USA.
Chmurny
Gwendolyn N
GN
McCloud
Thomas G
TG
Tucker
Kenneth D
KD
Shoemaker
Robert H
RH
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D005463:Fluoroacetates; D006172:Guyana; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019770:Lauraceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
C493702:6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, trifluoroacetic acid salt; D000935:Antifungal Agents; D005463:Fluoroacetates; D026121:Indole Alkaloids