title: Asthma and lung function 20 years after wheezing in infancy: results from a prospective follow-up study.
abstract: OBJECTIVE
  To determine the outcome until adulthood after wheezing in infancy, compared with pneumonia in infancy and with controls.
  
  
  METHODS
  An 18- to-20-year prospective cohort study.
  
  
  METHODS
  Pediatric department at a university hospital, providing primary hospital care for a defined population. Patients Fifty-four children hospitalized for bronchiolitis and 34 for pneumonia at younger than 2 years, and 45 controls with no early-life wheezing or hospitalization, were studied at median age 19 years.
  
  
  METHODS
  A questionnaire on asthma symptoms and medication, physical examination, flow volume spirometry (FVS), methacholine inhalation challenge (MIC), home peak expiratory flow (PEF) monitoring, and skin prick testing (SPT) to common inhalant allergens. The 2 asthma definitions were physician-diagnosed asthma and previously diagnosed asthma with recent asthmatic symptoms (physician-diagnosed asthma included).
  
  
  RESULTS
  By the 2 definitions, asthma was present in 30% (odds ratio [OR], 3.37; 95% confidence interval [CI], 1.12-10.10) and in 41% (OR 1.38; 95% CI, 0.37-5.21) in the bronchiolitis group, in 15% (OR, 5.50; 95% CI, 1.87-16.14) and in 24% (OR, 2.07; 95% CI, 0.59-7.22) in the pneumonia group, and in 11% in the control group. After bronchiolitis, the FVS values were forced vital capacity (FVC), 108% (SD, 13%) of predicted; forced expiratory volume in 1 second, 98% (SD, 12%); forced expiratory volume in 1 second divided by FVC, 91% (SD, 7.6%); midexpiratory flow at 50% of the FVC, 74% (SD, 19%); and midexpiratory flow at 25% of the FVC, 74% (SD, 22%). Bronchial reactivity by MIC was present in 25 (48%) of 52 subjects in the bronchiolitis group, in 13 (42%) of 31 in the pneumonia group, and in 14 (32%) of 44 in the control group. The prevalence of atopy (positive SPTs) was 48% to 63% in the 3 groups. In a logistic regression adjusted for atopy and smoking, infantile bronchiolitis was an independent risk factor for asthma by both definitions.
  
  
  CONCLUSIONS
  The increased risk for asthma persists until adulthood after bronchiolitis in infancy.
authors.affiliation: Department of Pediatrics, Kuopio University Hospital, and Kuopio University, Kuopio, Finland.
authors.forename: Eija
authors.initials: E
authors.lastname: Piippo-Savolainen
authors.forename: Sami
authors.initials: S
authors.lastname: Remes
authors.forename: Senja
authors.initials: S
authors.lastname: Kannisto
authors.forename: Kaj
authors.initials: K
authors.lastname: Korhonen
authors.forename: Matti
authors.initials: M
authors.lastname: Korppi
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000209:etiology*; D001988:Bronchiolitis / Q000150:complications*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology; D007223:Infant; D011014:Pneumonia / Q000150:complications*; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012135:Respiratory Sounds; D011795:Surveys and Questionnaires