Rapid irreversible encephalopathy associated with anti-D immune globulin treatment for idiopathic thrombocytopenic purpura.
Intravenous Rho (D) immune globulin (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura (ITP). Common side effects of IV RhIG include mild hemolysis, febrile reaction, and headache. Significant hemolysis with renal impairment following IV RhIG has been reported. We report a case of irreversible encephalopathy 48 hr following an infusion of IV RhIG for treatment of ITP.
Christopher
Kenneth
K
Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. kchristopher@rics.bwh.harvard.edu
Horkan
Clare
C
Barb
Ilie T
IT
Arbelaez
Christian
C
Hodgdon
Travis A
TA
Yodice
Paul C
PC
D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D006454:Hemoglobins; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000188:drug therapy*; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage / Q000009:adverse effects*
D006454:Hemoglobins; D016756:Immunoglobulins, Intravenous; D018029:Rho(D) Immune Globulin