title: Two cases of multiple eccrine spiradenoma with linear or localized formation.
abstract: We report two rare cases of recurrent, multiple eccrine spiradenoma. Both cases presented with extensive lesions comprised of multiple red papules of various sizes and a soft blue-red nodule. The first case was a 30-year-old woman. Her lesions followed a linear arrangement on her chin, and extended down the right side of the neck with spontaneous pain. The second case was a 57-year-old woman with tumors in a localized group on the left occipital region without pain. A search of the literature revealed only 15 reported cases of linear/zosteriform/nevoid multiple eccrine spiradenoma. Both cases were treated by surgical excision. Most of the red papules displayed typical histological features including two cell types: large clear cells with low-density cytoplasm; and small dark cells with high-density cytoplasm. The large soft tumors exhibited a variable histological appearance. In the first case, the cystic tumors displayed an homogeneous structure comprised of eosinophilic material. In the second case, the cystic tumors included abundant interstitial tissue.
authors.affiliation: Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Yoshida
authors.forename: Toshiki
authors.initials: T
authors.lastname: Sato
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Mayumi
authors.initials: M
authors.lastname: Matsuta
authors.forename: Toshihide
authors.initials: T
authors.lastname: Akasaka
mesh_terms: D006607:Adenoma, Sweat Gland / Q000473:pathology*; D000328:Adult; D001707:Biopsy, Needle; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D035583:Rare Diseases; D018570:Risk Assessment; D013544:Sweat Gland Neoplasms / Q000473:pathology*