title: [Structural modification and bioactivity of cyclovirobuxine D].
abstract: OBJECTIVE
  To search for new compounds for the treatment of cardiovascular diseases by structural modification of cyclovirobuxine D.
  
  
  METHODS
  According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.
  
  
  RESULTS
  Ten new compounds were syntheized and confirmed by spectra.
  
  
  CONCLUSIONS
  Endurance lacking oxygen activity and antiarrhythmia effects of some analogues of cyclovirobuxine D were tested. Some compounds showed better activity than cyclovirobuxine D.
authors.affiliation: West China School of Pharmacy, Sichuan University, China. denglan234@sina.com
authors.forename: Lan
authors.initials: L
authors.lastname: Deng
authors.forename: Heng
authors.initials: H
authors.lastname: Huang
authors.forename: Ming-xia
authors.initials: MX
authors.lastname: Xu
authors.forename: Shi-qing
authors.initials: SQ
authors.lastname: Zhou
authors.forename: Xing-wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Miao
authors.initials: M
authors.lastname: Lu
authors.forename: Fang
authors.initials: F
authors.lastname: Ren
authors.forename: Dai-qing
authors.initials: DQ
authors.lastname: Li
mesh_terms: D015308:Anaerobic Threshold / Q000187:drug effects*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D031235:Buxus / Q000737:chemistry; D002725:Chloroform; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal; C032939:cyclovirobuxine D; D002725:Chloroform