The cardiac beta2-adrenergic signalling a new role for the cPLA2.
The cardiac actions of catecholamines have long been attributed to the predominant beta(1)-AR subtype that couples to the classical Gs/AC/cAMP pathway. Recent research clearly indicates that cardiac beta(2)-ARs play a functional role in healthy heart and assume increasing importance in failing and aged heart. beta(2)-ARs are primarily coupled to an atypical compartmentalized cAMP pathway, regulated by phosphorylation and/or oligomerization of beta(2)-ARs, and under the control of additional beta(2)-AR/Gi-coupled lipidic pathways, the impact of which seems to vary depending on the animal species, the developmental and pathophysiological state. This review focuses, more especially, on one of the last identified beta(2)-AR/Gi pathway, namely the cPLA(2).
Pavoine
Catherine
C
Unité INSERM 581, Hôpital Henri Mondor, 94010 Creteil, France. pavoine@im3.inserm.fr
Defer
Nicole
N
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology; D021941:Caveolae / Q000378:metabolism / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D019281:Dimerization; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000502:physiology; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000502:physiology; D054513:Group IV Phospholipases A2; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000502:physiology; D008955:Models, Cardiovascular; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D010741:Phospholipases A / Q000737:chemistry / Q000502:physiology*; D018342:Receptors, Adrenergic, beta-1 / Q000502:physiology; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity; D018754:Ventricular Dysfunction / Q000378:metabolism / Q000503:physiopathology
D002316:Cardiotonic Agents; D007527:Isoenzymes; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2; D016718:Arachidonic Acid; D000242:Cyclic AMP; D019869:Phosphatidylinositol 3-Kinases; D010741:Phospholipases A; D054513:Group IV Phospholipases A2; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D019205:GTP-Binding Protein alpha Subunits, Gs