title: Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
abstract: Of the 206 patients who contracted Severe Acute Respiratory Syndrome (SARS) in Singapore five developed large artery cerebral infarctions. Four patients were critically-ill and three died. Intravenous immunoglobulin was given to three patients. An increased incidence of deep venous thrombosis and pulmonary embolism was also observed among the critically-ill patients. We believe our experience warrants an increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombotic tendency, is contemplated.
authors.affiliation: Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433. umapathi_thirugnanam@nni.com.sg
authors.forename: T
authors.initials: T
authors.lastname: Umapathi
authors.forename: Ai Ching
authors.initials: AC
authors.lastname: Kor
authors.forename: N
authors.initials: N
authors.lastname: Venketasubramanian
authors.forename: C C Tchoyoson
authors.initials: CC
authors.lastname: Lim
authors.forename: Boon Chuan
authors.initials: BC
authors.lastname: Pang
authors.forename: Tseng Tsai
authors.initials: TT
authors.lastname: Yeo
authors.forename: Cheng Chuan
authors.initials: CC
authors.lastname: Lee
authors.forename: Poh Lian
authors.initials: PL
authors.lastname: Lim
authors.forename: Kuperan
authors.initials: K
authors.lastname: Ponnudurai
authors.forename: Khoon Leong
authors.initials: KL
authors.lastname: Chuah
authors.forename: Puay Hoon
authors.initials: PH
authors.lastname: Tan
authors.forename: Dessmon Yeng Huoa
authors.initials: DY
authors.lastname: Tai
authors.forename: Sze Peng Brenda
authors.initials: SP
authors.lastname: Ang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D045169:Severe Acute Respiratory Syndrome / Q000150:complications* / Q000473:pathology / Q000628:therapy; D020521:Stroke / Q000209:etiology* / Q000473:pathology; D015898:Tomography Scanners, X-Ray Computed; D014715:Vertebrobasilar Insufficiency / Q000209:etiology / Q000473:pathology / Q000628:therapy
chemical_list: D016756:Immunoglobulins, Intravenous