Spectrophotometric analysis of raloxifene hydrochloride in pure and pharmaceutical formulations.
Two simple and sensitive spectrophotometric methods (A and B) for the determination of raloxifene hydrochloride in bulk samples and pharmaceutical formulations are described. Method A is based on the oxidation of the drug with ferric chloride and coupling with potassium ferric cyanide. Method B is based on reduction of the drug with Fehling's reagent. Bluish green color formed in method A absorbs at 735 nm and brown color produced in method B absorbs at 430 nm.
Dharuman
J
J
K.M.C.H. College of Pharmacy, Kovai Estate, Coimbatore, India. dharumanj@yahoo.com
Ravichandran
V
V
Thirumoorthy
N
N
Dharamsi
A
A
D002626:Chemistry, Pharmaceutical; D002712:Chlorides; D005290:Ferric Compounds; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D020849:Raloxifene Hydrochloride / Q000032:analysis*; D012015:Reference Standards; D020845:Selective Estrogen Receptor Modulators / Q000032:analysis*; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D002712:Chlorides; D005290:Ferric Compounds; D007202:Indicators and Reagents; D020845:Selective Estrogen Receptor Modulators; D012996:Solutions; D013607:Tablets; D020849:Raloxifene Hydrochloride; C024555:ferric chloride