AFM as a high-resolution imaging tool and a molecular bond force probe.
This focused review summarizes certain aspects of recent developments in the use of atomic force microscope in high-resolution imaging of membrane-bound biological macromolecules and in molecular force probing of the interaction between biological conjugates. We point out the pros and cons in these approaches and critically analyze details involved in experiments.
Yang
Jie
J
Physics Department, Cook Building, University of Vermont, Burlington, VT 05405, USA. jyang@zoo.uvm.edu
D000327:Adsorption; D000818:Animals; D001703:Biophysics / Q000379:methods*; D002462:Cell Membrane / Q000378:metabolism; D004530:Egg Yolk / Q000737:chemistry; D006460:Hemolysin Proteins / Q000737:chemistry*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D018625:Microscopy, Atomic Force / Q000379:methods*; D015335:Molecular Probes; D009210:Myofibrils / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry*; D013997:Time Factors
D006460:Hemolysin Proteins; D008051:Lipid Bilayers; D046911:Macromolecular Substances; D015335:Molecular Probes; D010713:Phosphatidylcholines