p75 neurotrophin receptor signaling in the nervous system.
The neurotrophin receptor p75(NTR) has long been known as a receptor for neurotrophins that promote survival and differentiation. Consistent with the role of neurotrophins, p75(NTR) is expressed during the developmental stages of the nervous system. However, p75(NTR) is re-expressed in various pathological conditions in the adult. We now know that p75(NTR) has the ability to elicit bi-directional signals, that result in the inhibition as well as the promotion of the neurite outgrowth. p75(NTR) is a key receptor for myelin-derived inhibitory cues that contribute to the lack of regeneration of the central nervous system.
Hasegawa
Yuiko
Y
Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Yamagishi
Satoru
S
Fujitani
Masashi
M
Yamashita
Toshihide
T
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D020800:Receptor, Nerve Growth Factor