title: Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy.
abstract: Although the safety profiles of coronary stents eluting sirolimus or paclitaxel do not seem to differ from those of bare metal stents in the short-to-medium term, concern has arisen about the potential for late stent thromboses related to delayed endothelialisation of the stent struts. We report four cases of angiographically-confirmed stent thrombosis that occurred late after elective implantation of polymer-based paxlitaxel-eluting (343 and 442 days) or sirolimus-eluting (335 and 375 days) stents, and resulted in myocardial infarction. All cases arose soon after antiplatelet therapy was interrupted. If confirmed in systematic long-term follow-up studies, our findings have potentially serious clinical implications.
authors.affiliation: Thoraxcenter, Erasmus University, Rotterdam, Netherlands.
authors.forename: Eugène P
authors.initials: EP
authors.lastname: McFadden
authors.forename: Eugenio
authors.initials: E
authors.lastname: Stabile
authors.forename: Evelyn
authors.initials: E
authors.lastname: Regar
authors.forename: Edouard
authors.initials: E
authors.lastname: Cheneau
authors.forename: Andrew T L
authors.initials: AT
authors.lastname: Ong
authors.forename: Timothy
authors.initials: T
authors.lastname: Kinnaird
authors.forename: William O
authors.initials: WO
authors.lastname: Suddath
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Weissman
authors.forename: Rebecca
authors.initials: R
authors.lastname: Torguson
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Kent
authors.forename: August D
authors.initials: AD
authors.lastname: Pichard
authors.forename: Lowell F
authors.initials: LF
authors.lastname: Satler
authors.forename: Ron
authors.initials: R
authors.lastname: Waksman
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000628:therapy; D003328:Coronary Thrombosis / Q000209:etiology*; D003331:Coronary Vessels; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D017239:Paclitaxel / Q000008:administration & dosage*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents / Q000009:adverse effects*
chemical_list: D010975:Platelet Aggregation Inhibitors; D017239:Paclitaxel; D020123:Sirolimus