Acetate-mediated production of orotic acid by ura3 mutants of Candida albicans.
Candida albicans ura3 mutants were found to produce large amounts of orotic acid when the growth medium was supplemented with sodium acetate. Experiments with 13C-labeled acetate showed that the acetate served as a precursor of orotic acid. This system of acetate-mediated production of orotic acid is similar to other documented microbial producers in yield but unique for its acetate requirement.
Nezu
Takashi
T
Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Shimokawa
Osamu
O
D000085:Acetates / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D003470:Culture Media; D005656:Fungal Proteins / Q000235:genetics; D009154:Mutation; D009963:Orotic Acid / Q000378:metabolism*
D000085:Acetates; D003470:Culture Media; D005656:Fungal Proteins; D009963:Orotic Acid