Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome: role of obesity.
Neuropeptide Y (NPY) and leptin are two peptides involved in the regulation of body weight, energy balance, and sympathetic tone. This study investigates the independent role of apneas and obesity on NPY and leptin plasma levels in patients with obstructive sleep apnea syndrome (OSAS). To this end we compared their values in 23 obese (body mass index > 30 kg/m2) and 24 nonobese (body mass index < 27 kg/m2) patients with OSAS, and in 19 obese and 18 nonobese control subjects without OSAS. Patients who used continuous positive airway pressure for more than 4 hours/night were reexamined 3 and 12 months later. We found that NPY levels were increased (p < 0.01) in patients with OSAS independently of obesity. Leptin levels were also increased in OSAS but this was mostly associated to obesity. Continuous positive airway pressure treatment reduced NPY levels in all patients and leptin levels only in nonobese patients (p < 0.01). We concluded that NPY and leptin plasma levels are increased in patients with OSAS. Yet, whereas the former appear independent of obesity, the latter are mostly associated with obesity.
Barceló
Antonia
A
Servei de Anàlisis Cliniques and Pneumologia, Hospital Universitari Son Dureta, Institut Universitari de Ciencies de la Salut, Palma de Mallorca, Spain.
Barbé
Ferran
F
Llompart
Elena
E
de la Peña
Mónica
M
Durán-Cantolla
Joaquin
J
Ladaria
Antoni
A
Bosch
Margalida
M
Guerra
Lourdes
L
Agustí
Alvar G N
AG
D000704:Analysis of Variance; D015415:Biomarkers; D016022:Case-Control Studies; D045422:Continuous Positive Airway Pressure; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood*; D009765:Obesity / Q000097:blood; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy; D018709:Statistics, Nonparametric
D015415:Biomarkers; D020738:Leptin; D009478:Neuropeptide Y