Serum levels of angiogenic cytokines decrease after antineoplastic radiotherapy.
Serum levels of angiogenic cytokines decrease after radiotherapy in patients with cancer and their may have an impact on response to treatment and progression-free survival. Here, we have evaluated sera of patients before and after radiotherapy for various tumour types for levels of soluble fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) to assess whether these factors decrease after radiotherapy, and whether their diminution is related to the radiation dose, tumour type, age and haemoglobin level. We demonstrate that levels of FGF-2 and VEGF, but not HGF, decrease significantly, and that the extent of their diminution is related to the radiation dose and response.
Ria
Roberto
R
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Policlinico, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
Portaluri
Maurizio
M
Russo
Francesca
F
Cirulli
Teresa
T
Di Pietro
Giulia
G
Bambace
Santa
S
Cucci
Francesco
F
Romano
Teodoro
T
Vacca
Angelo
A
Dammacco
Franco
F
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004307:Dose-Response Relationship, Radiation; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy; D009389:Neovascularization, Pathologic; D011379:Prognosis; D011878:Radiotherapy; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D006454:Hemoglobins; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D017228:Hepatocyte Growth Factor