Synthesis and biological studies of 1-amino beta-carbolines.
A selection of 1-amino-substituted beta-carbolines have been prepared by amination of 1-chloro-beta-carboline as simple mimics of manzamine A and chloroquine and their intercalating ability, anticancer and antimalarial activity were studied.
Boursereau
Yohan
Y
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK.
Coldham
Iain
I
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000977:Antiparasitic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D002417:Cattle; D045744:Cell Line, Tumor; D006801:Humans; D010963:Plasmodium falciparum / Q000187:drug effects / Q000502:physiology
D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D002243:Carbolines