Early postoperative complications following liver transplantation.
Liver transplantation is a highly successful treatment for patients with end-stage liver disease and acute liver failure. However, serious postoperative complications can significantly compromise patient survival. Complications can be technical, medical, or immunological in nature. The risk of developing early postoperative complications is associated with the patient's preoperative condition, the quality of the donor liver, the quality of the donor and recipient procedure, initial graft function, and perioperative anaesthesiological and intensive care management. The patient's preoperative condition can include gastrointestinal bleeding, acute renal failure, a requirement for cathecholamines or mechanical ventilation, and prolonged encephalopathy for the most detrimental risk factors for developing early postoperative complications. The necessity for prolonged mechanical ventilation or the requirement for reintubation after transplantation can significantly increase the risk of developing pneumonia, sepsis, and multiple organ dysfunction. A decrease in infectious and other complications can be achieved by early postoperative enteral nutition, including the application of probiotics.
Mueller
Andrea R
AR
Universitätsklinikum Schleswig Holstein, Campus Kiel, Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Arnold-Heller Str. 7, 24105 Kiel, Germany. amueller@chirurgie-sh.de
Platz
Klaus-Peter
KP
Kremer
Bernd
B
D003251:Constriction, Pathologic; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006499:Hepatic Artery; D006801:Humans; D007442:Intubation, Intratracheal; D016031:Liver Transplantation / Q000009:adverse effects* / Q000276:immunology; D011169:Portal Vein; D012086:Reoperation; D012121:Respiration, Artificial; D017131:Thrombectomy; D013927:Thrombosis / Q000209:etiology; D018608:Ultrasonography, Doppler; D014684:Venae Cavae / Q000473:pathology; D020246:Venous Thrombosis / Q000209:etiology / Q000601:surgery