Effect of lauric acid on transdermal penetration of phenazepam in vivo.
We studied the effect of lauric acid on transdermal penetration of phenazepam in vivo. It was found that treatment with lauric acid 3-fold increased the maximum anticonvulsive effect of phenazepam applied in a transdermal therapeutic system in comparison with the control. Study of the pharmacokinetics of phenazepam transdermal therapeutic system showed its higher bioavailability in the presence of lauric acid (f=0.9).
Kravchenko
I A
IA
I I Metcnhikov Odessa National University, Odessa. irina@krav.intes.odessa.ua
Golovenko
N Ya
NY
Larionov
V B
VB
Aleksandrova
A I
AI
Ovcharenko
N V
NV
D000279:Administration, Cutaneous; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001569:Benzodiazepines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D001921:Brain / Q000378:metabolism; D004357:Drug Synergism; D020100:Hydrogels / Q000493:pharmacokinetics; D007850:Lauric Acids / Q000493:pharmacokinetics* / Q000494:pharmacology; D051379:Mice; D010539:Permeability; D012867:Skin / Q000187:drug effects* / Q000378:metabolism
D000927:Anticonvulsants; D020100:Hydrogels; D007850:Lauric Acids; C030358:lauric acid; D001569:Benzodiazepines; C017928:phenazepam