[A clinical study of estramustine phosphate sodium for the treatment of hot flushes in men with prostate cancer].
OBJECTIVE
To assess the effectiveness and tolerability of estramustine sodium phosphate in men with hot flushes during combined androgen blockade (CAB) therapy for prostate cancer.


METHODS
Seven men with moderate to severe hot flushes were received estramustine sodium phosphate. Treatment response was assessed by hot flush score.


RESULTS
A significant reduction in the hot flush score was seen with all patients. No thromboembolic complications occurred in any patients.


CONCLUSIONS
Estramustine sodium phosphate appears to be a promising, well-tolerated and useful therapy for men with hot flushes during CAB treatment for prostate cancer.
Fukuhara
Shinichiro
S
Department of Urology, Ikeda Municipal Hospital.
Yokoyama
Shohei
S
Tsutahara
Koichi
K
Mori
Naoki
N
Hara
Tsuneo
T
Yamaguchi
Seiji
S
D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects*; D004961:Estramustine / Q000627:therapeutic use*; D019584:Hot Flashes / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
D000726:Androgen Antagonists; D004961:Estramustine