[Hepatoprotectors containing phospholipids decrease the immunosuppressive effect of prednisolone in rats with experimental toxic hepatitis].
The experiments on rats with a model toxic hepatitis induced by tetrachloromethane showed that hepatoprotectors containing phospholipids (eplir and essentiale) introduced in combination with prednisolone decrease the immunodepressant effect of this glucocorticoid, as manifested by a decrease in the atrophy of thymus and an increase in the amount of blood lymphocytes, the number of splenic blasts, and the functional activity of mononuclear cells in C3b and Fc(gamma) receptors in peritoneal exudate.
Vengerovskiĭ
A I
AI
Ogorodova
L M
LM
Perevozchikova
T V
TV
D000818:Animals; D002338:Carotenoids / Q000494:pharmacology* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D004338:Drug Combinations; D007108:Immune Tolerance / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology* / Q000627:therapeutic use; D010743:Phospholipids / Q000494:pharmacology* / Q000627:therapeutic use; D011239:Prednisolone / Q000037:antagonists & inhibitors*; D051381:Rats
D004338:Drug Combinations; D007166:Immunosuppressive Agents; D010713:Phosphatidylcholines; D010743:Phospholipids; C064845:eplir; C011246:essential 303 forte; D002338:Carotenoids; D011239:Prednisolone