High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia.
Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic indicators, we analyzed telomerase activity (TA), a known marker of neoplastic proliferation, in granulocytes (PMNs) and mononuclear cells (MNCs) from 22 female patients with ET and PV. Clonality status was determined by investigation of X chromosome inactivation patterns (XCIPs). We found a statistically significant positive correlation between high TA and monoclonal pattern of XCIP. Therefore, our data suggest that the use of multiple tumor markers may contribute to a better understanding of the deregulated physiology of these disorders and provide useful prognostic factors.
Ferraris
Anna Maria
AM
Ematologia Oncologica Istituto Nazionale per la Ricerca sul Cancro, the Dipartimento di Medicina Interna, University of Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy. annamaria.ferraris@istge.it
Mangerini
Rosa
R
Pujic
Natalija
N
Racchi
Omar
O
Rapezzi
Davide
D
Gallamini
Andrea
A
Casciaro
Salvatore
S
Gaetani
Gian Franco
GF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002999:Clone Cells; D004303:Dosage Compensation, Genetic; D005260:Female; D006098:Granulocytes / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008875:Middle Aged; D011087:Polycythemia Vera / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D019098:Telomerase / Q000378:metabolism*; D013920:Thrombocythemia, Essential / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor; D019098:Telomerase