Experimental study of effect of perfluorohexyloctane to retina.
OBJECTIVE
To investigate the effect of perfluorohexyloctane to the retina of rabbit eyes.


METHODS
Perfluorohexyloctane (experimental group) or BSS(control group) into vitreous cavities of fifteen vitrectomized New Zealand white rabbits. A slit-lamp biomicroscope and an indirect ophthalmoscope were used to examine all the eyes pre- and postoperation. Histopathological examination was performed after the rabbits were sacrificed.


RESULTS
Perfluorohexyloctane was injected into the vitreous cavity forming a single large layerclear globe. No retinal detachment and cataract were found. The edema of outer plexiform was significant, and then get a darker cytoplasm and nucleoplasm.


CONCLUSIONS
Perfluorohexyloctane in vitreous cavity had significant side effects on retina. As a silicone solvent, it should be removed out completely after injection. We don't recommend to use it as a new intraocular tamponade.
Li
Chunfang
C
Zhongshan Ophthalmic center, Sun Yet-san University, Guangzhou 510060 , China.
Ding
Xiaoyan
X
Lu
Lin
L
Feng
Guanguang
G
Zheng
Huling
H
D000818:Animals; D005260:Female; D005466:Fluorocarbons / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D014822:Vitreous Body / Q000187:drug effects
D005466:Fluorocarbons; C118616:perfluorohexyl-octan