title: Thiazolyl and isothiazolyl azomethine derivatives with anti-inflammatory and antioxidant activities.
abstract: Several thiazolyl/benzothiazolyl/benzo[d]isothiazolyl Schiff bases and hydrazones have been tested as anti-inflammatory agents and five new compounds have been synthesized. The anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema test (inhibition 16.3-64%). The compounds were tested for antioxidant activity as hydroxyl scavengers and for their ability to interact with the stable free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, Greece. geronik@pharm.auth.gr
authors.forename: Athina
authors.initials: A
authors.lastname: Geronikaki
authors.forename: Paola
authors.initials: P
authors.lastname: Vicini
authors.forename: Matteo
authors.initials: M
authors.lastname: Incerti
authors.forename: Dimitra
authors.initials: D
authors.lastname: Hadjipavlou-Litina
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002351:Carrageenan; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D010851:Picrates / Q000737:chemistry; D011247:Pregnancy; D021281:Quantitative Structure-Activity Relationship; D012545:Schiff Bases; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010851:Picrates; D012545:Schiff Bases; D013844:Thiazoles; D013882:Thiosemicarbazones; D017665:Hydroxyl Radical; D002351:Carrageenan; C004931:1,1-diphenyl-2-picrylhydrazyl; D004121:Dimethyl Sulfoxide