title: Gastrointestinal stromal tumour of the duodenum in a 7-year-old boy.
abstract: We report a 7-year-old boy presenting with an acute upper gastrointestinal (GI) haemorrhage subsequently diagnosed to have a very rare duodenal gastrointestinal stromal tumour (GIST). Endoscopy, pertechnetate and red cell scans were negative. Abdominal US detected a 17-mm mass lesion of the third part of the duodenum. This was confirmed on CT and shown to be hypervascular on selective angiography. At laparotomy, a 20-mm submucosal duodenal lesion was found associated with mucosal ulceration. Immunohistochemical analysis revealed it to be positive for CD117 (c-KIT protein) consistent with a GIST. We emphasize the importance of a thorough abdominal US examination in children with GI haemorrhage and the consideration of GIST in the diagnosis after the common causes have been excluded.
authors.affiliation: Department of Radiology, Guy's Hospital NHS Trust, St Thomas' Street, London SE1 9RT, UK. jaqhughes@hotmail.com
authors.forename: Jacqueline Ann
authors.initials: JA
authors.lastname: Hughes
authors.forename: Jane Valmai
authors.initials: JV
authors.lastname: Cook
authors.forename: Ahmid
authors.initials: A
authors.lastname: Said
authors.forename: Sonny K
authors.initials: SK
authors.lastname: Chong
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Towu
authors.forename: John
authors.initials: J
authors.lastname: Reidy
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016099:Endoscopy, Gastrointestinal; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008551:Melena / Q000175:diagnosis; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D012509:Sarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit