[Study on preparation of beta-cyclodextrin inclusion complex of volatile oil in xiongdan xiaoyan capsules].
OBJECTIVE
To study optimum inclusion conditions for volatile oil from three medicinal slices in Xiongdan Xiaoyan capsules.


METHODS
Saturated water solution method (agitation method), ultrasonic method and rubbing method were studied and compared. The preparation conditions of ultrasonic method were investigated by the orthogonal test.


RESULTS
The optimum inclusion conditions of ultrasonic method were established.


CONCLUSIONS
The ultrasonic method can be used for production of inclusion complex in the factory with high inclusion rate and was effectiveness.
Xu
Xiong-liang
XL
Laboratory of Targeting and New Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Zhang
Zhi-rong
ZR
He
Zu-xing
ZX
Huang
Guo-qing
GQ
Ran
Dong
D
D029969:Angelica / Q000737:chemistry; D002214:Capsules; D004337:Drug Carriers; D004338:Drug Combinations; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000302:isolation & purification; D027541:Mentha / Q000737:chemistry; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D032134:Saururaceae / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D014465:Ultrasonics; D047392:beta-Cyclodextrins
D002214:Capsules; D004337:Drug Carriers; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D047392:beta-Cyclodextrins; C031215:betadex