Polymorphism and conservation of the genes encoding Qa1 molecules.
To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1(a)-like and Qa1(b)-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.
Hermel
Evan
E
Indiana University School of Medicine, Evansville Center, 8600 University Blvd., Evansville, IN 47712-3534, USA.
Hart
Andrew J
AJ
Gunduz
Irfan
I
Acton
Hector
H
Kim
Christina
C
Wurth
Mark
M
Uddin
Samina
S
Smith
Caryn
C
Fischer Lindahl
Kirsten
K
Aldrich
Carla J
CJ
D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens