title: Effect of orally administered hydrocortisone on intraocular pressure in nonglaucomatous dogs.
abstract: OBJECTIVE
  To determine the effect of oral hydrocortisone on intraocular pressure (IOP) in ocular normotensive dogs.
  
  
  METHODS
  Seventeen ocular normotensive dogs. Procedures Dogs were randomly assigned to treatment (n = 9) and control (n = 8) groups. Dogs in the treatment group received hydrocortisone, 3.3 mg/kg PO every 8 h, and dogs in the control group received gelatin capsule placebo PO every 8 h for 5 weeks. Applanation tonometry was performed on both eyes of all dogs prior to treatment and then once weekly for 5 weeks during hydrocortisone treatment.
  
  
  RESULTS
  No significant effect of treatment was noted for right (P = 0.1013) or left (P = 0.1157) eyes during the treatment period, nor was there significant interaction of treatment by week for the right (P = 0.9456) or left (P = 0.3577) eyes. A significant rise in IOP over the treatment period was noted in both right (P < 0.0001) and left (P = 0.0006) eyes of both groups, but was unrelated to treatment.
  
  
  CONCLUSIONS
  Orally administered hydrocortisone does not significantly increase IOP in nonglaucomatous dogs when administered over a 5-week period.
authors.affiliation: Department of Small Animal Clinical Sciences Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. iherring@vt.edu
authors.forename: Ian P
authors.initials: IP
authors.lastname: Herring
authors.forename: Erin S
authors.initials: ES
authors.lastname: Herring
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Ward
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004285:Dogs / Q000502:physiology*; D005260:Female; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011897:Random Allocation; D014065:Tonometry, Ocular / Q000662:veterinary
chemical_list: D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone