title: Relationship between protein deficiency in the ration of rats during early ontogeny and function of enzyme systems of digestive and non-digestive organs in adult life.
abstract: Low protein content in the ration of rat pups during transfer from mixed to definitive nutrition (days 21-30 of life) has a negative impact on digestive function of the small intestine and trophic and barrier functions of the large intestine, liver, and kidneys and increases (sucrase, glycyl-L-leucin dipeptidase) or decreases (alkaline phosphatase, aminopeptidase M, glycyl-L-leucine dipeptidase) enzyme activities in these organs in 6-month-old rats. Protein deficiency during the early ontogeny modulates functioning of the enzyme systems in digestive and non-digestive organs in adult life, which can lead to the development of not only gastrointestinal, but other visceral diseases.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. nmtimof@pavlov.infran.ru
authors.forename: N M
authors.initials: NM
authors.lastname: Timofeeva
authors.forename: A A
authors.initials: AA
authors.lastname: Nikitina
authors.forename: V V
authors.initials: VV
authors.lastname: Egorova
authors.forename: L A
authors.initials: LA
authors.lastname: Gordova
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis / Q000378:metabolism; D000818:Animals; D018826:CD13 Antigens / Q000032:analysis / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage*; D004150:Dipeptidases / Q000032:analysis / Q000378:metabolism; D007422:Intestines / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D011488:Protein Deficiency; D051381:Rats; D017208:Rats, Wistar; D013393:Sucrase / Q000032:analysis / Q000378:metabolism; D000520:alpha-Glucosidases / Q000032:analysis / Q000378:metabolism
chemical_list: D004044:Dietary Proteins; D000469:Alkaline Phosphatase; D000520:alpha-Glucosidases; D013393:Sucrase; D018826:CD13 Antigens; D004150:Dipeptidases; C020825:cytosol non-specific dipeptidase