[Identification of tumor antigens: strategies and perspectives].
The identification of tumor antigens is crucial for the development of antigen-specific immunotherapies in cancer. Ideal target antigens for immunotherapies have a tumor specific expresssion pattern. Antigen expresssion in solid tumors is typically heterogenous. Therefore an effective immunotherapy should target several antigens simultaneously (polyvalent vaccine). Here we discuss strategies how tumor antigens can be identified and further analyzed as potential target antigens for active immunotherapy (cancer vaccine).
Jäger
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Klinik und Poliklinik für Onkologie, Universitätssspital Zürich.
Zippelius
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Knuth
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D000951:Antigens, Neoplasm / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology; D002454:Cell Differentiation; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D000939:Epitopes; D005260:Female; D015723:Gene Library; D006801:Humans; D016233:Immunotherapy, Active; D008297:Male; D008544:Melanocytes / Q000166:cytology / Q000276:immunology; D008545:Melanoma / Q000276:immunology / Q000628:therapy; D009154:Mutation; D011471:Prostatic Neoplasms / Q000276:immunology; D012334:RNA, Neoplasm / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012984:Software; D013601:T-Lymphocytes / Q000276:immunology; D013736:Testicular Neoplasms / Q000276:immunology; D013737:Testis / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000276:immunology
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D018076:DNA, Complementary; D004273:DNA, Neoplasm; D000939:Epitopes; D012334:RNA, Neoplasm