Aging-related research in the "-omics" age.
The application of high-throughput technologies to aging-related research has the potential to dramatically enhance our understanding of how longevity is determined at a molecular level. Genome-scale studies are being carried out in every major model system used for aging-related research, and new technologies are being developed to rapidly identify mutations or small-molecules that increase life span. A meta-analysis of data derived from genome-wide studies of aging in simple eukaryotes will allow the identification of conserved determinants of longevity that can be tested in mammals.
Kaeberlein
Matt
M
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. kaeber@u.washington.edu
D000375:Aging / Q000235:genetics*; D000818:Animals; D023281:Genomics / Q000379:methods*; D006801:Humans