title: Regurgitation of the native aortic valve caused by thrombus formation after heterotopic heart transplantation.
abstract: A 61-year-old man, who had undergone heterotopic heart transplantation, had severe regurgitation through his native aortic valve develop 16 years later, which caused severe heart failure. At operation the regurgitation was found to be due to development of an organized thrombus in the sinuses of Valsalva tethering aortic leaflets. The management of this previously undescribed complication of heterotopic heart transplantation and the implications for other groups of patients (such as those receiving treatment with a left ventricular assist device) are discussed.
authors.affiliation: Harefield Hospital, Harefield, Middlesex, United Kingdom.
authors.forename: Omar
authors.initials: O
authors.lastname: Mangoush
authors.forename: Toufan
authors.initials: T
authors.lastname: Bahrami
authors.forename: Fabio
authors.initials: F
authors.lastname: De Robertis
authors.forename: Jonathan
authors.initials: J
authors.lastname: Swinburn
authors.forename: Nicholas
authors.initials: N
authors.lastname: Banner
authors.forename: Magdi H
authors.initials: MH
authors.lastname: Yacoub
authors.forename: Asghar
authors.initials: A
authors.lastname: Khaghani
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001022:Aortic Valve Insufficiency / Q000209:etiology* / Q000601:surgery; D001157:Arterial Occlusive Diseases / Q000209:etiology; D001026:Coronary Artery Bypass; D004554:Electric Countershock; D017809:Fatal Outcome; D006322:Heart Aneurysm / Q000601:surgery; D006333:Heart Failure / Q000209:etiology / Q000601:surgery; D016027:Heart Transplantation / Q000379:methods*; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications; D009203:Myocardial Infarction / Q000150:complications; D017202:Myocardial Ischemia / Q000150:complications / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D012850:Sinus of Valsalva; D017180:Tachycardia, Ventricular / Q000150:complications; D017131:Thrombectomy; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D016042:Transplantation, Heterotopic; D014693:Ventricular Fibrillation / Q000150:complications / Q000628:therapy
chemical_list: D000925:Anticoagulants