A successful pregnancy outcome using frozen testicular sperm from a chimeric infertile male with a 46, XX/46, XY karyotype: case report.
BACKGROUND
We report a very rare case of the successful delivery of a healthy infant fathered by an infertile chimera.


METHODS
ICSI was performed using frozen sperm. The karyotypes of peripheral lymphocytes were examined with a G-banding stain.


RESULTS
Chromosomal analysis prior to ICSI revealed a 46, XX [28]/46, XY [2] karyotype chimera. As an infant, the subject was diagnosed as a true hermaphrodite, and underwent a hysterectomy and oophorectomy. A small number of sperm were found in minced testicular tissue, and they were stored for ICSI.


CONCLUSIONS
To the best of our knowledge, this is the first case report of a successful pregnancy and delivery of a healthy infant fathered by an infertile chimera (46, XX/46, XY) following ICSI using frozen testicular sperm.
Sugawara
Nobuo
N
Iwaki Women's Clinic, 3-2, Ookishita, Uchigo, Iwaki, Fukushima, 973-8403, Japan. sugawara@iwaki-fu.or.jp
Tokunaga
Yo
Y
Maeda
Machiko
M
Komaba
Rie
R
Araki
Yasuhisa
Y
D000328:Adult; D002678:Chimera / Q000235:genetics*; D015925:Cryopreservation; D012734:Disorders of Sex Development / Q000150:complications / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000209:etiology / Q000235:genetics* / Q000628:therapy*; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012662:Semen Preservation; D020554:Sperm Injections, Intracytoplasmic