title: Tumor-targeting of viral vectors for cancer gene therapy by using antibodies or their genes against tumor-associated antigens.
abstract: Gene therapy is a promising modality for the treatment of malignant tumors for which conventional therapies are often inadequate. Various therapeutic genes have shown promise for tumor cell killing. However, successful gene therapy depends on the development of efficient and targeted gene transfer vectors. The aim of this review is to summarize the tumor-targeting viral vectors for cancer gene therapy by utilizing antibodies or genes against tumor-associated antigens.
authors.affiliation: Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka, Japan. kurokima@fukuoka-u.ac.jp
authors.forename: Masahide
authors.initials: M
authors.lastname: Kuroki
authors.forename: Motomu
authors.initials: M
authors.lastname: Kuroki
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Shibaguchi
authors.forename: Ken
authors.initials: K
authors.lastname: Hachimine
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Kinugasa
authors.forename: Adel
authors.initials: A
authors.lastname: Badran
mesh_terms: D000256:Adenoviridae / Q000235:genetics* / Q000276:immunology; D000912:Antibodies, Neoplasm / Q000235:genetics* / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics / Q000276:immunology*; D006801:Humans; D012190:Retroviridae / Q000235:genetics* / Q000276:immunology
chemical_list: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm