title: Massive fetal ascites causing increased middle cerebral artery systolic velocity.
abstract: BACKGROUND
  An elevated peak systolic velocity in the middle cerebral artery, assessed by Doppler ultrasonography, is commonly associated with fetal anemia. Other fetal abnormalities associated with a high middle cerebral artery velocity have rarely been reported.
  
  
  METHODS
  A fetus with increasing ascites was found to have an elevated middle cerebral artery peak systolic velocity. Following paracentesis, the peak systolic velocity normalized. Peak systolic velocity continued to correlate with the level of ascites, falling to normal ranges when large-volume amniocentesis and paracentesis were performed. At birth, the infant was found to have a normal hematocrit.
  
  
  CONCLUSIONS
  An elevated middle cerebral artery peak systolic velocity may result from massive fetal ascites without anemia. We hypothesize that the massive ascites led to increased afterload of the heart, with relatively preserved preload, leading to an increased systolic blood pressure and an elevated middle cerebral artery peak systolic velocity.
authors.affiliation: Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Gloria
authors.initials: G
authors.lastname: Chiang
authors.forename: Deborah
authors.initials: D
authors.lastname: Levine
authors.forename: Philip
authors.initials: P
authors.lastname: Hess
authors.forename: Kee-Hak
authors.initials: KH
authors.lastname: Lim
mesh_terms: D000328:Adult; D001201:Ascites / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001783:Blood Flow Velocity; D004899:Erythroblastosis, Fetal / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D005323:Fetal Monitoring; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018615:Ultrasonography, Doppler, Color; D016216:Ultrasonography, Prenatal