[Preventive efficacy of tianeptine in recurrent depression with frequent exacerbations].
The results of the studies of 4 Russian research centers are summarized. Tianeptine (coaxil) was used in the treatment of 55 patients with ICD-10 diagnosis of recurrent depressive disorder (F32.1), 50 patients have completely finished the treatment. Tianeptine was assigned in dosage of 12.5 mg 3 times daily (patients over 65 years old received 25.0 mg daily) during 12 months. The drug was shown to have a high preventive efficacy for the disorder. Sixty-one percent of patients were full-responders. Taken together with partial responders (13%), an improvement was observed in 74% patients. The drug demonstrated a well tolerability with a rare and mild expression of side-effects.
Mosolov
S N
SN
Vertogradova
O P
OP
Panteleeva
G P
GP
Morozova
M A
MA
Kostiukova
E G
EG
Gorodnichev
A V
AV
Abramova
L I
LI
Bannikov
G S
GS
Timofeef
I V
IV
Oleĭchik
I V
IV
Artiukh
V V
VV
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000517:prevention & control* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D010507:Periodicity; D012008:Recurrence; D013841:Thiazepines / Q000008:administration & dosage / Q000627:therapeutic use*
D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine