[Heparin inhibits metastatization of experimental melanoma].
Heparin treatment, at human equivalent doses, modulates coagulation parameters in mice similarly to the human situation. Heparins were tested in various melanoma metastasis models for their antimetastatic activity. Heparins were active against melanoma metastasis without influencing the primary tumor. Tumor cell-induced platelet aggregation was not the primary target of heparins, since melanoma cells were not active in this respect. Our results support the notion that heparins have antimetastatic activity.
Tóvári
József
J
Országos Onkológiai Intézet, Budapest 1122, Hungary.
Bereczky
Bíborka
B
Gilly
Réka
R
Skopál
Judit
J
Vágó
Agnes
A
Tímár
József
J
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D008546:Melanoma, Experimental / Q000517:prevention & control* / Q000556:secondary; D051379:Mice
D000970:Antineoplastic Agents; D006493:Heparin