Serum cholinesterase inhibition by omeprazole and lansoprazole.
Omeprazole inhibited human and rat serum cholinesterase by approximately 5 to 60% over the 0.5 to 50 mg/L (1.4-140 microM) concentration range. In contrast lansoprazole only produced 20-30% inhibition at the highest concentration of 10 mg/L (29 microM). Thus omeprazole but not lansoprazole is likely to potentiate the effect of succinylcholine at human clinical concentrations by inhibiting its hydrolysis in vivo by serum cholinesterases.
Mequid
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Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia.
Ramzan
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D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D002800:Cholinesterase Inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D064747:Lansoprazole; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D002800:Cholinesterase Inhibitors; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D064747:Lansoprazole; D009853:Omeprazole