title: [Formalized evaluation of the ionizing radiation effects modification due to the contribution of a number of factors on Earth and in space flight].
abstract: The article reviews data of radiobiological investigations into the contribution of different physical factors preceding and succeeding exposure to the lethal doses of radiation. To reveal synergism, results of the experiments flown on biosats Kosmos-690 with and Kosmos-605 without a gamma-source were compared and coefficients of modification of the immediate body response by specific spaceflight factors were determined. Expressed in dose equivalents, these modification coefficients are used to calculate the generalized dose and radiation risk to spacecrew in orbit. The earlier published radiation damage model served as a basis for a hypothesis explaining some of the effects of radiation combined with non-radiation factors in space flight.
authors.forename: A V
authors.initials: AV
authors.lastname: Shafirkin
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Grigor'ev
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000503:physiopathology / Q000528:radiation effects; D018534:Earth, Planet; D005118:Extraterrestrial Environment; D006321:Heart / Q000503:physiopathology / Q000528:radiation effects; D006410:Hematopoiesis / Q000502:physiology / Q000528:radiation effects; D008099:Liver / Q000201:enzymology / Q000503:physiopathology / Q000528:radiation effects; D051379:Mice; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D011874:Radiometry / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D013026:Space Flight / Q000295:instrumentation*; D013997:Time Factors