Kahiricosides II-V, cycloartane glycosides from an Egyptian collection of Astragalus kahiricus.
Four cycloartane-type saponins, kahiricosides II-V (1-4), were isolated from the aerial parts of Astragalus kahiricus of Egyptian origin. Their structures were established as 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-beta-D-glucopyranoside, 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-(2'-O-acetyl)-beta-D-glucopyranoside, 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-(6'-O-acetyl)-beta-D-glucopyranoside, and 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-beta-D-glucopyranosyl-27-O-beta-D-glucopyranoside based on chemical and spectral evidences. All compounds exhibited very weak cytotoxicity against the A2780 ovarian cancer cell line.
Radwan
Mohamed M
MM
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, 3111 Hahn Hall, MC 0212, Blacksburg, VA 24061-0212, USA.
El-Sebakhy
Nadia A
NA
Asaad
Aya M
AM
Toaima
Soad M
SM
Kingston
David G I
DG
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D027883:Astragalus Plant / Q000737:chemistry*; D045744:Cell Line, Tumor; D004534:Egypt; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry; D014315:Triterpenes / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D014315:Triterpenes; C495033:kahiricoside II; C495030:kahiricoside III; C495031:kahiricoside IV; C495032:kahiricoside V