No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population.
The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.
Yu
Y-Q
YQ
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, China.
Tao
R
R
Wei
J
J
Xu
Q
Q
Liu
S-Z
SZ
Ju
G-Z
GZ
Shi
J-P
JP
Zhang
X
X
Xie
L
L
Shen
Y
Y
D044466:Asian People / Q000235:genetics*; D002681:China; D051546:Cyclooxygenase 2; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008565:Membrane Proteins; D010741:Phospholipases A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D010741:Phospholipases A