Genetics of human systemic lupus erythematosus: the emerging picture.
Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease with partially understood etiology, which can affect virtually any organ. Despite suggestions to the contrary, SLE is proving to be a reliable phenotype for genetic studies. Similar to many other autoimmune diseases, SLE demonstrates a complex pattern of inheritance that is consistent with the involvement of multiple susceptibility genes as well as environmental risk factors. During the past several years, some new candidate genes have been implicated in induction of SLE through association studies, and multiple susceptibility regions have been detected through genome-wide linkage studies. Many of the susceptibility effects have been confirmed by independent studies.
Nath
Swapan K
SK
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA. Swapan-Nath@omrf.ouhsc.edu
Kilpatrick
Jeff
J
Harley
John B
JB
D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics; D000954:Antigens, Surface / Q000235:genetics; D051017:Apoptosis Regulatory Proteins; D060908:CTLA-4 Antigen; D003165:Complement System Proteins / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000235:genetics; D037601:Mannose-Binding Lectin / Q000235:genetics; D010375:Pedigree; D061026:Programmed Cell Death 1 Receptor; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D037601:Mannose-Binding Lectin; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D017452:Receptors, IgG; D003165:Complement System Proteins