Liver transplantation-associated hypercalcemia followed by acute renal dysfunction.
A 34-year-old woman with liver insufficiency due to glycogen storage disease III underwent a living spousal liver transplantation. Soon after the successful operation, moderate hypercalcemia along with hyperbilirubinemia emerged without clarified reasons. The hypercalcemia persisted for over a month despite calcitonin treatment and the serum calcium level surged to 13.2 mg/dl with albumin correction. Renal dysfunction was indicated by an acute increase in serum creatinine (approximately 0.8 to approximately 2.8 mg/ml), which was assumed to be hypercalcemia-induced and was effectively treated with bisphosphonate, pamidronate (30 mg, i.v.). Recent topics related to transplantation-associated hypercalcemia are discussed.
Shirasawa
Yuichi
Y
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya.
Nomura
Tomoyuki
T
Yoshida
Atsuhiro
A
Hashimoto
Takashi
T
Kimura
Genjiro
G
Ito
Makoto
M
D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D005260:Female; D006010:Glycogen Storage Disease Type III / Q000150:complications; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology*; D017093:Liver Failure / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors