title: Effect of lauric acid on transdermal penetration of phenazepam in vivo.
abstract: We studied the effect of lauric acid on transdermal penetration of phenazepam in vivo. It was found that treatment with lauric acid 3-fold increased the maximum anticonvulsive effect of phenazepam applied in a transdermal therapeutic system in comparison with the control. Study of the pharmacokinetics of phenazepam transdermal therapeutic system showed its higher bioavailability in the presence of lauric acid (f=0.9).
authors.affiliation: I I Metcnhikov Odessa National University, Odessa. irina@krav.intes.odessa.ua
authors.forename: I A
authors.initials: IA
authors.lastname: Kravchenko
authors.forename: N Ya
authors.initials: NY
authors.lastname: Golovenko
authors.forename: V B
authors.initials: VB
authors.lastname: Larionov
authors.forename: A I
authors.initials: AI
authors.lastname: Aleksandrova
authors.forename: N V
authors.initials: NV
authors.lastname: Ovcharenko
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001569:Benzodiazepines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D001921:Brain / Q000378:metabolism; D004357:Drug Synergism; D020100:Hydrogels / Q000493:pharmacokinetics; D007850:Lauric Acids / Q000493:pharmacokinetics* / Q000494:pharmacology; D051379:Mice; D010539:Permeability; D012867:Skin / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D020100:Hydrogels; D007850:Lauric Acids; C030358:lauric acid; D001569:Benzodiazepines; C017928:phenazepam