Proton magnetic resonance spectroscopy (1H-MRS) of hippocampus, basal ganglia, and vermis of cerebellum in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome).
OBJECTIVE
Whether patients with schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome, GS) have specific changes in brain metabolism was examined in this study.


METHODS
This study applied proton magnetic resonance spectroscopy (1H-MRS) to the hippocampus, basal ganglia, and vermis of the cerebellum of schizophrenic patients with GS (n=15) or without GS (n=15), all diagnosed according to DSM-IV criteria, and healthy subjects (n=15).


RESULTS
In the hippocampus, schizophrenic patients with GS showed a significant decrease of N-acetyl aspartate/creatine-phosphocreatinine (NAA/Cr) and myoinositol/creatine-phosphocreatinine (mI/Cr) ratios compared to healthy subjects and schizophrenic patients without GS, while schizophrenic patients without GS showed only a significant decrease of NAA/Cr compared to healthy subjects. In the basal ganglia, schizophrenic patients with GS showed a significant decrease of ml/Cr compared to schizophrenic patients without GS and healthy subjects, and schizophrenic patients with GS showed a significant decrease of NAA/Cr compared to healthy subjects. In the vermis of the cerebellum, schizophrenic patients with GS showed only a significant decrease of ml/Cr compared to healthy subjects, although schizophrenic patients without GS did not show a significant decrease of ml/Cr compared to healthy subjects.


CONCLUSIONS
The findings suggest that schizophrenia with GS is a more severe sub-type with regard to brain metabolism.
Miyaoka
Tsuyoshi
T
Department of Psychiatry, Shimane University Medical School, 89-1 Enyacho, Izumo 693-8501, Japan. Miyanyan@med.shimane.u.ac.jp
Yasukawa
Rei
R
Mizuno
Shoichi
S
Sukegawa
Tsuruhei
T
Inagaki
Takuji
T
Horiguchi
Jun
J
Seno
Haruo
H
Oda
Kazushige
K
Kitagaki
Hajime
H
D000328:Adult; D001479:Basal Ganglia / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D002531:Cerebellum / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005878:Gilbert Disease / Q000150:complications* / Q000523:psychology*; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D011522:Protons; D012559:Schizophrenia / Q000175:diagnosis* / Q000209:etiology*
D011522:Protons