title: The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate.
abstract: Chloral hydrate is a sedative commonly used in pediatric medicine. It was evaluated for genotoxicity in cultured peripheral blood lymphocytes of infants who were given chloral hydrate for sedation. Sister chromatid exchange and micronucleus frequencies were determined before and after chloral hydrate administration. After treatment, the frequencies of sister chromatid exchange and micronuclei were significantly increased, suggesting that chloral hydrate has moderate genotoxic potential in infants.
authors.affiliation: Department of Medical Genetics, Medical Faculty, Ataturk University, 25240 Erzurum, Turkey. mevlitikbal@hotmail.com
authors.forename: Mevlit
authors.initials: M
authors.lastname: Ikbal
authors.forename: Ayhan
authors.initials: A
authors.lastname: Tastekin
authors.forename: Hasan
authors.initials: H
authors.lastname: Dogan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Pirim
authors.forename: Rahmi
authors.initials: R
authors.lastname: Ors
mesh_terms: D001973:Bromodeoxyuridine; D002697:Chloral Hydrate / Q000009:adverse effects*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D012854:Sister Chromatid Exchange / Q000187:drug effects
chemical_list: D002697:Chloral Hydrate; D001973:Bromodeoxyuridine