Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia.
OBJECTIVE
To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions.


METHODS
Prospective and retrospective observational study.


METHODS
Dermatology outpatient clinic in a general hospital.


METHODS
Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period.


METHODS
None.


METHODS
Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing.


RESULTS
HLA-DR4 (DRB1*0404) was significantly increased (P<.001; odds ratio, 3.9; 95% confidence interval, 1.86-8.03). Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32.


CONCLUSIONS
The HLA-DRB1*0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.
García-Corona
Cristina
C
Department of Dermatology, Hospital General Dr Manuel Gea González, Tlalpan, México.
Vega-Memije
Elisa
E
Mosqueda-Taylor
Adalberto
A
Yamamoto-Furusho
Jesús K
JK
Rodríguez-Carreón
Alma A
AA
Ruiz-Morales
Jorge A
JA
Salgado
Norma
N
Granados
Julio
J
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000453:epidemiology* / Q000821:virology*; D005787:Gene Frequency; D015804:HLA-DR4 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012189:Retrospective Studies; D044465:White People / Q000235:genetics
D004279:DNA, Viral; D015804:HLA-DR4 Antigen