A synthetic polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate), stimulates insulin release from RINm5F insulinoma cells.
A water-soluble phospholipid-like polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate) (PMC(18), average molecular weight = 4.3 x 10(4)), at a concentration (0.5-5 mg/ml) showing no inhibition of cell proliferation, stimulated insulin release from RINm5F rat insulinoma cells in a concentration- and time-related manner. But poly(2-methacryloyloxyethyl phosphorylcholine) and other synthetic phospholipid-like polymers failed to stimulate insulin release.
Maruyama
Susumu
S
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan. s-maruyama@aist.go.jp
Hu
Jianen
J
Yamanaka
Akiko
A
Ichimura
Toshiaki
T
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D005089:Exocytosis / Q000187:drug effects* / Q000502:physiology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007340:Insulinoma / Q000378:metabolism*; D008689:Methacrylates / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011109:Polymethacrylic Acids; D051381:Rats; D014407:Tumor Cells, Cultured
D007328:Insulin; D008689:Methacrylates; D011109:Polymethacrylic Acids; C499977:poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate); C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine