title: Hydrazine-induced post-chemiluminescence phenomenon of permanganate-luminol reaction and its applications.
abstract: The post-chemiluminescence phenomenon arising from the permanganate-luminol reaction induced by hydrazine and isoniazid was investigated. When hydrazine or isoniazid was injected into the mixture after the end of the reaction of permanganate with alkaline luminol, a new chemiluminescence (CL) reaction was initiated and strong CL signal was detected. A possible CL mechanism is suggested, based upon the studies of the kinetic characteristics of the CL reaction, the UV-visible spectra, the CL spectra and some other experiments. The present reactions allow the determination of 0.1-10.0 mg/L hydrazine and 0.02-1.0 mg/L isoniazid, with detection limits of 0.03 mg/L and 0.006 mg/L, respectively. The method was applied to the determination of isoniazid in pharmaceutical preparations.
authors.affiliation: College of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of China.
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Du
authors.forename: Jiuru
authors.initials: J
authors.lastname: Lu
mesh_terms: D000995:Antitubercular Agents / Q000032:analysis; D006834:Hydrazines / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D007202:Indicators and Reagents; D007538:Isoniazid / Q000032:analysis; D008163:Luminescent Measurements / Q000379:methods*; D008165:Luminol / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D011196:Potassium Permanganate / Q000737:chemistry*; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
chemical_list: D000995:Antitubercular Agents; D006834:Hydrazines; D007202:Indicators and Reagents; D012996:Solutions; D013607:Tablets; D011196:Potassium Permanganate; C029424:hydrazine; D008165:Luminol; D006861:Hydrogen Peroxide; D010100:Oxygen; D007538:Isoniazid