[Urotensin II--new peptide which regulates function of cardiovascular system].
Human urotensin II is one of the new peptide which regulates function of cardiovascular system. It stimulates cardiomyocytes and vascular smooth muscle hypertrophy and also shows inotropic properties. Urotensin II has the potential pathophysiological role in cardiovascular, lung and kidney diseases. The vascular function of this peptide in humans, however, has yet to be determined. Human urotensin II is an endocrine hormone with range vasoactive properties dependent on the anatomic site and the species. Preliminary results showed strong expression of urotensin II in the cardiomyocytes, and to a lesser extent in the vascular smooth muscle cells, endothelial cells, and inflammatory cells of patients with end-stage chronic heart failure. The development of selective human urotensin II antagonists may be of utility in the management of cardiovascular disorders.
Jołda-Mydłowska
Beata
B
Katedra i Klinika Kardiologii Akademia Medyczna we Wrocławiu.
D002319:Cardiovascular System / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D014579:Urotensins / Q000378:metabolism*
D014579:Urotensins; C029677:urotensin II