[Cytomegalovirus infection in peptic ulcer in renal transplant recipient: a case report].
Gastroduodenal ulcers in renal transplant recipients are usually originated from excessive acid secretion or infection of Helicobacter pyroli. Herein, we report a case of cytomegalovirus (CMV)--induced gastric ulcer following cadaveric renal transplantation. The patient was a 48-year-old man with chronic renal failure and received cadaveric renal transplantation. A month later, he had epigastralgia without CMV-positive antigenemia and received gastrointestinal fiberscopy. Endoscopically, gastric ulcer was identified. Histological findings revealed conspicious nuclear enlargement of the non-epithelial cells in the ulcer bed, which indicated CMV infection. The patient was treated with ganciclovir for 2 weeks and the symptom was relieved. He discharged with a good renal function on day 75 posttransplant. CMV infection plays an important role in gastric ulcer after renal transplantation. Antigenemia assay dose not seem feasible for the detection of CMV-induced gastric ulcer.
Ishiguro
Shin
S
Department of Urology, Ehime University School of Medicine, Ehime 791-0295, Japan.
Ikeda
Tetsuhiro
T
Shimamoto
Kenji
K
Tanji
Nozomu
N
Ohoka
Hiroji
H
Yokoyama
Masayoshi
M
D000998:Antiviral Agents / Q000627:therapeutic use; D002102:Cadaver; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections; D013276:Stomach Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D016896:Treatment Outcome
D000998:Antiviral Agents; D015774:Ganciclovir