A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy.
OBJECTIVE
The purpose of this study was to compare the analgesic activity of 2 doses of parecoxib sodium, ketorolac, and morphine with placebo after gynecologic surgery that requires laparotomy.


METHODS
In a randomized, controlled, double-blind, parallel-group study, 208 patients, after surgical hysterectomy, received single-dose intravenous placebo, parecoxib sodium 20 mg or 40 mg, ketorolac 30 mg, or morphine 4 mg followed by multiple-dose parecoxib sodium or ketorolac as needed. Primary efficacy variables were time to onset of analgesia, pain intensity differences, pain relief, time to first rescue/remedication, and global evaluation of study medication.


RESULTS
Single-dose parecoxib sodium 40 mg provided significantly better pain responses to placebo or morphine 4 mg and was comparable to ketorolac 30 mg. Multiple-dose parecoxib sodium 20 mg, 4 times daily, or 40 mg, twice daily, was comparable to ketorolac 30 mg, 4 times daily. Parecoxib sodium was well tolerated.


CONCLUSIONS
Parecoxib sodium is an effective analgesic in the management of acute postoperative pain after laparotomy surgery.
Bikhazi
George B
GB
University of Miami School of Medicine, Miami, FL, USA.
Snabes
Michael C
MC
Bajwa
Zahid H
ZH
Davis
Derek J
DJ
LeComte
Diane
D
Traylor
Louise
L
Hubbard
Richard C
RC
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007044:Hysterectomy; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D020910:Ketorolac / Q000008:administration & dosage / Q000627:therapeutic use*; D007813:Laparotomy; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007555:Isoxazoles; D009020:Morphine; C409945:parecoxib; D020910:Ketorolac