title: Plasminogen activities and concentrations in patients with sporadic Creutzfeldt-Jakob disease.
abstract: Human plasminogen has been shown to interact with the abnormal disease-specific prion protein. Till now, no data are available for patients with Creutzfeldt-Jakob disease (CJD). Therefore, we compared plasminogen concentrations and plasminogen activities in patients with sporadic CJD and controls with other dementia, which were collected in the framework of the German CJD Surveillance study. Patients with CJD had significantly higher plasminogen concentrations than patients with other forms of dementia and plasminogen specific activities were lower in CJD patients. The reasons for these abnormalities are not clear at the moment. The results may reflect a disease-specific prion protein and plasminogen interaction in patients with CJD. Other possible explanations are plasminogen polymorphisms and genotypes with distinct plasminogen activity levels in CJD than in controls, which should be a subject for further studies.
authors.affiliation: Department of Neurology, Georg-August University, Robert-Koch-Str. 40, 37075 Göttingen, Germany. IngaZerr@aol.com
authors.forename: Inga
authors.initials: I
authors.lastname: Zerr
authors.forename: Monika
authors.initials: M
authors.lastname: Bodemer
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kaboth
authors.forename: Hans
authors.initials: H
authors.lastname: Kretzschmar
authors.forename: Michael
authors.initials: M
authors.lastname: Oellerich
authors.forename: Victor W
authors.initials: VW
authors.lastname: Armstrong
mesh_terms: D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000097:blood* / Q000523:psychology; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D010958:Plasminogen