Three-component coupling based on the "cation pool" method.
Sequential one-pot three-component coupling reactions have been developed based on the "cation pool" method. An N-acyliminium ion generated by the "cation pool" method adds to an electron-rich carbon-carbon double bond, such as enamine derivatives and vinyl sulfides, to form the second "cation pool". The addition of nucleophiles such as allylsilanes, enol silyl ethers, Grignard reagents, and organoaluminum compounds led to the formation of the corresponding three-component coupling products.
Suga
Seiji
S
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan. suga@sbchem.kyoto-u.ac.jp
Nishida
Tomoaki
T
Yamada
Daisuke
D
Nagaki
Aiichiro
A
Yoshida
Jun-Ichi
J