[Ischemia and hypoxia. An attempt to explain the different rates of retinal ganglion cell death in glaucoma].
In hypoxic or ischemic states, the receptors of the ganglion cells are overstimulated by release of neurotransmitters. Glutamate and GABA (gamma-aminobutyric acid) are the decisive neurotransmitters in the retina. It is presumed that the extent of cell death depends on the degree of depolarization, which in turn is determined by the amount of excitatory (glutamate) or inhibitory (GABA) receptors of the corresponding ganglion cell. The assumption is that the receptor profile of the individual ganglion cells determines the sensitivity of these cells to hypoxia or ischemia, i.e., the time up to cell death, and thus represents the underlying cause of the different rates of cell death in primary chronic open-angle glaucoma. Research on this receptor profile could be of pivotal importance for the approach to neuroprotective treatment of primary chronic open-angle glaucoma.
Schmidt
K-G
KG
Augenklinik, Universität, Dresden. k.g.schmidt@gmx.de
Pillunat
L E
LE
Osborne
N N
NN
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D009410:Nerve Degeneration / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D018917:Optic Neuropathy, Ischemic / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*; D012162:Retinal Degeneration / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology
D018696:Neuroprotective Agents; D018377:Neurotransmitter Agents