title: Neuropsychological correlates of diffusion tensor imaging in schizophrenia.
abstract: Patients with schizophrenia (n = 41) and healthy comparison participants (n = 46) completed neuropsychological measures of intelligence, memory, and executive function. A subset of each group also completed magnetic resonance diffusion tensor imaging (DTI) studies (fractional anisotropy and cross-sectional area) of the uncinate fasciculus (UF) and cingulate bundle (CB). Patients with schizophrenia showed reduced levels of functioning across all neuropsychological measures. In addition, selective neuropsychological-DTI relationships emerged. Among patients but not controls, lower levels of declarative-episodic verbal memory correlated with reduced left UF, whereas executive function errors related to performance monitoring correlated with reduced left CB. The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia.
authors.affiliation: Clinical Neuroscience Division.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Nestor
authors.affiliation: Clinical Neuroscience Division.
authors.forename: Marek
authors.initials: M
authors.lastname: Kubicki
authors.affiliation: Clinical Neuroscience Division.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Gurrera
authors.affiliation: Clinical Neuroscience Division.
authors.forename: Margaret
authors.initials: M
authors.lastname: Niznikiewicz
authors.affiliation: Clinical Neuroscience Division.
authors.forename: Melissa
authors.initials: M
authors.lastname: Frumin
authors.affiliation: Clinical Neuroscience Division.
authors.forename: Robert W
authors.identifier: 0000-0001-5705-7495
authors.initials: RW
authors.lastname: McCarley
authors.affiliation: Clinical Neuroscience Division.
authors.forename: Martha E
authors.initials: ME
authors.lastname: Shenton
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology*; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology*; D013223:Statistics as Topic / Q000379:methods