Knowing when to let go: endosomal release of LDL from the LDL-Receptor.
In this issue of Molecular Cell, Blacklow and colleagues use NMR structural analyses and the combination of deletion mapping, site-directed mutagenesis and LDL release assays to examine the molecular basis for low pH-induced release of LDL from the LDL receptor.
Debose-Boyd
Russell A
RA
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
D008078:Cholesterol, LDL / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D016297:Mutagenesis, Site-Directed; D011973:Receptors, LDL / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017384:Sequence Deletion
D008078:Cholesterol, LDL; D011973:Receptors, LDL