A 2:1 coupling reaction of arynes with aldehydes via o-quinone methides: straightforward synthesis of 9-arylxanthenes.
[reaction: see text] A novel coupling reaction, where an aldehyde and two molar amounts of an aryne are assembled selectively, has been demonstrated to afford diverse 9-arylxanthene derivatives in one step. o-Quinone methide arising from the [2 + 2] cycloaddition of an aldehyde with an aryne was postulated as a transient intermediate.
Yoshida
Hiroto
H
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan. yhiroto@hiroshima-u.ac.jp
Watanabe
Masahiko
M
Fukushima
Hiroyuki
H
Ohshita
Joji
J
Kunai
Atsutaka
A