[The change in reproductive ability of male mice exposed to vinblastine and X-rays].
The effects of male mice to vinblastine (VBL) and combined X-rays-vinblastine treatments on the sperm quantity and quality, fertility and induction of foetal deaths and congenital malformations in the offspring were investigated. VBL and combined X-rays-VBL exposure caused decrease in testes weight and sperm count as well as increased percent of abnormal spermatozoa. Both vinblastine and X-rays-vinblastine combination induced increase in frequency of DNA single strand breaks in germ cells. The highest dose of VBL induced decrease of percent of pregnant females, decrease of live foetuses and induction of dominant lethal mutations after exposure some stages of spermatogenesis. Combined exposure to low doses of X-rays and vinblastine enhanced the frequency of dead implants. After exposure to VBL on its own as well as to combination of low doses of both agents increase in the frequency of congenital malformations was not observed.
Dobrzyńska
Małgorzata M
MM
Zakład Ochrony Radiologicznej i Radiobiologii, Państwowy Zakład Higieny, 00-791 Warszawa.
Słowikowska
Maria G
MG
Mikulska
Urszula
U
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000016:Abnormalities, Radiation-Induced / Q000209:etiology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D003131:Combined Modality Therapy / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D013091:Spermatogenesis / Q000187:drug effects / Q000528:radiation effects; D013094:Spermatozoa / Q000187:drug effects / Q000528:radiation effects; D013737:Testis / Q000187:drug effects* / Q000528:radiation effects*; D013997:Time Factors; D014747:Vinblastine / Q000009:adverse effects*; D014965:X-Rays / Q000009:adverse effects*
D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine