The pharmacology of CGRP-responsive receptors in cultured and transfected cells.
Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however, this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.
Hay
D L
DL
School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
Conner
A C
AC
Howitt
S G
SG
Takhshid
M A
MA
Simms
J
J
Mahmoud
K
K
Poyner
D R
DR
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002460:Cell Line; D006801:Humans; D018003:Receptors, Calcitonin / Q000378:metabolism*; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism*; D014162:Transfection
D018003:Receptors, Calcitonin; D018015:Receptors, Calcitonin Gene-Related Peptide; D018000:Receptors, Peptide; D015740:Calcitonin Gene-Related Peptide