title: Gamma/delta T-cell lymphoma as a recurrent complication after transplantation.
abstract: We present a case of gamma-delta (gammadelta) T-cell lymphoma as a recurrent event in a pediatric liver transplant recipient. Liver transplantation was performed during infancy in an 18-month-old black girl because of cryptogenic cirrhosis. The patient received immunosuppression with cyclosporine and prednisone. Five years after transplantation, the patient was found to have a gammadelta T-cell lymphoma located in retroperitoneal nodes. She received chemotherapy and did well, remaining disease-free for 6 years. She remained only on prednisone for prevention of graft rejection, but was noted to have a non-tender skin nodule that upon biopsy proved to be again a gammadelta T-cell lymphoma. However, comparison of tissue from both tumors revealed that the second occurrence of this malignancy was a de novo event, differing from the first by immunophenotypic and immunohistochemical characteristics, and TCR rearrangement. The patient continues to do well, without evidence of disease recurrence, after being treated again with chemotherapy. A summary of the literature is presented and comparison of our case is made.
authors.affiliation: Department of Pediatrics, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA. rgardn@lsuhsc.edu
authors.forename: Renée V
authors.initials: RV
authors.lastname: Gardner
authors.forename: Maria C
authors.initials: MC
authors.lastname: Velez
authors.forename: David L
authors.initials: DL
authors.lastname: Ode
authors.forename: Joong Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Hernan
authors.initials: H
authors.lastname: Correa
mesh_terms: D000293:Adolescent; D016572:Cyclosporine / Q000494:pharmacology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D016399:Lymphoma, T-Cell / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011241:Prednisone / Q000494:pharmacology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta; D016572:Cyclosporine; D011241:Prednisone