Preparation of benzolactams by Pd(OAc)2-catalyzed direct aromatic carbonylation.
We developed a new method for Pd(II)-catalyzed direct aromatic carbonylation in a phosphine-free catalytic system using Pd(OAc)2 and Cu(OAc)2 in an atmosphere of CO gas containing air. The carbonylation proceeded with ortho-palladation, inducing a remarkable site selectivity to afford a variety of five- or six-membered benzolactams from secondary omega-arylalkylamines, such as N-alkylbenzylamines or N-alkylphenethylamines.
Orito
Kazuhiko
K
Laboratory of Organic Synthesis, Division of Molecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan. orito@org-mc.eng.hokudai.ac.jp
Horibata
Akiyoshi
A
Nakamura
Takatoshi
T
Ushito
Harumi
H
Nagasaki
Hideo
H
Yuguchi
Motoki
M
Yamashita
Satoshi
S
Tokuda
Masao
M