title: Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models.
abstract: The importance of some recognized risk factors on genetic influences for coronary heart disease (CHD) needs further clarification. The aim of the present study was therefore to study the impact of known risk factors on genetic influences for CHD-death. Both twin (correlated gamma-frailty) and non-twin models (univariate gamma-frailty) were utilized and compared regarding their suitability for genetic analyses. The study population consisted of twins born in Sweden between 1886 and 1925. As expected, our findings indicate that genetic influences are important for CHD-death. Inclusion of risk factors in the twin-model increased heritability estimates, primarily due to a substantial reduction in non-shared environmental variances. The genetic influences for CHD-death are only marginally mediated through the risk factors among males, but more so among females. Although the outcome phenotype used in the present study is not behavioral, the analyses demonstrate the potential of frailty models for quantitative genetic analyses of categorical phenotypes.
authors.affiliation: Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Slobodan.zdrakovic@imm.ki.se
authors.forename: Slobodan
authors.initials: S
authors.lastname: Zdravkovic
authors.forename: Andreas
authors.initials: A
authors.lastname: Wienke
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Pedersen
authors.forename: Marjorie E
authors.initials: ME
authors.lastname: Marenberg
authors.forename: Anatoli I
authors.initials: AI
authors.lastname: Yashin
authors.forename: Ulf
authors.initials: U
authors.lastname: de Faire
mesh_terms: D015992:Body Mass Index; D003327:Coronary Disease / Q000235:genetics* / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D017533:Marital Status; D008954:Models, Biological; D016016:Proportional Hazards Models; D012307:Risk Factors; D012727:Sex Characteristics; D012907:Smoking; D018433:Twin Studies as Topic