title: Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation.
abstract: Transforming growth factor-beta (TGF-beta) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-beta in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-beta in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-beta; however, TGF-beta-mediated tissue remodelling can be a serious complication in such diseases.
authors.affiliation: Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH-7270 Davos, Switzerland. csweber@siaf.unizh.ch
authors.forename: Carsten B
authors.initials: CB
authors.lastname: Schmidt-Weber
authors.forename: Kurt
authors.initials: K
authors.lastname: Blaser
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology / Q000502:physiology*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D028322:Inhibin-beta Subunits / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta; C103008:inhibin beta A subunit; D028322:Inhibin-beta Subunits