title: Survival of patients with periampullary carcinoma is predicted by lymph node 8a but not by lymph node 16b1 status.
abstract: BACKGROUND
  The aim of this study was to assess the impact of metastatic disease in lymph nodes 8a and 16b1 (as defined by the Japanese Pancreas Society) on survival in patients with periampullary malignancy.
  
  
  METHODS
  Patients undergoing resection for primary pancreatic ductal adenocarcinoma or intrapancreatic bile duct adenocarcinoma were identified from a prospective database (September 1997-May 2003).
  
  
  RESULTS
  Thirteen of 54 and ten of 44 evaluable patients had metastatic involvement of lymph nodes 8a and 16b1 respectively. Metastatic involvement of lymph node 8a was associated with a significantly shorter median survival (197 versus 470 days; P = 0.003) but metastatic involvement of lymph node 16b1 did not affect survival (457 versus 503 days; P = 0.185). Multivariate analysis showed lymph node 8a status to be the strongest predictor of outcome (P = 0.006). Median survival of those with metastatic lymph node 8a was not significantly different from that of 81 patients with overt metastatic periampullary cancer at the time of diagnosis (98 days; P = 0.072)
  
  
  CONCLUSIONS
  Lymph node 8a was an independent prognostic factor in patients with periampullary malignancy, but lymph node 16b1 was not. Survival in those with metastatic lymph node 8a was not significantly different from that in patients with metastatic disease at presentation. Preoperative determination of lymph node 8a status may have important implications in selecting patients for treatment.
authors.affiliation: Department of Surgery, University of Liverpool, Royal Liverpool Hospital, Liverpool, UK.
authors.forename: S
authors.initials: S
authors.lastname: Connor
authors.forename: L
authors.initials: L
authors.lastname: Bosonnet
authors.forename: P
authors.initials: P
authors.lastname: Ghaneh
authors.forename: N
authors.initials: N
authors.lastname: Alexakis
authors.forename: M
authors.initials: M
authors.lastname: Hartley
authors.forename: F
authors.initials: F
authors.lastname: Campbell
authors.forename: R
authors.initials: R
authors.lastname: Sutton
authors.forename: J P
authors.initials: JP
authors.lastname: Neoptolemos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D001653:Bile Ducts, Intrahepatic; D021441:Carcinoma, Pancreatic Ductal / Q000401:mortality* / Q000556:secondary; D003138:Common Bile Duct Neoplasms / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis