Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus.
OBJECTIVE
To investigate the possible association between Fc receptor (FcR) gamma polymorphisms and systemic lupus erythematosus (SLE).


METHODS
We have investigated the full FcR gamma gene for polymorphisms using polymerase chain reaction (PCR)-single strand conformational polymorphism and DNA sequencing. The polymorphisms identified were genotype using PCR-restriction fragment length polymorphism. Systemic lupus erythematosus cases and controls were available from 3 ethnic groups: Turkish, Spanish and Caucasian. The study was conducted in the year 2001 at the Arthritis Research Campaign, Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom.


RESULTS
Five single nucleotide polymorphisms were identified, 2 in the promoter, one in intron 4 and, 2 in the 3' UTR. Four of the 5 single nucleotide polymorphisms (SNPs) were relatively common and investigated in the 3 populations. Allele and genotype frequencies of all 4 investigated SNPs were not statistically different between cases and controls.


CONCLUSIONS
Fc receptor gamma gene does not appear to contribute to SLE susceptibility. The identified polymorphisms may be useful in investigating other diseases where receptors containing the FcR gamma subunit contribute to the pathology.
Alansari
Aliya
A
The Centre for Integrated Genomic Medical Research, Manchester University Medical School, Manchester, United Kingdom.
Gul
Ahmet
A
Inanc
Murat
M
Ordi
Jose
J
Teh
Lee-Suan
LS
Ollier
William E
WE
Gonzalez-Gay
Miguel A
MA
Hajeer
Ali H
AH
D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011961:Receptors, Fc / Q000235:genetics*; D012529:Saudi Arabia; D044465:White People / Q000235:genetics*
D011961:Receptors, Fc