Oxaspirodion, a new inhibitor of inducible TNF-alpha expression from the Ascomycete chaetomium subspirale. Production, isolation and structure elucidation.
In a search for new inhibitors of the TNF-alpha promoter activity, a new spiro-compound, designated oxaspirodion, was obtained as a mixture of four isomers from fermentations of the ascomycete Chaetomium subspirale. The structure was determined by a combination of spectroscopic techniques.
Rether
Jan
J
Institut für Biotechnologie und Wirkstoff-Forschung e. V., Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
Erkel
Gerhard
G
Anke
Timm
T
Sterner
Olov
O
D002597:Chaetomium / Q000378:metabolism*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011401:Promoter Regions, Genetic / Q000187:drug effects*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000235:genetics*
D005663:Furans; D013141:Spiro Compounds; D014409:Tumor Necrosis Factor-alpha; C493110:oxaspirodion