[Expression and significance of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer].
OBJECTIVE
To study the expression and significance of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in human prostate cancer.


METHODS
SP immunohistochemical method was employed to investigate the expression of alpha subunit of GM-CSF receptors in 48 cases of primary prostate cancer, 20 benign prostate hyperplasia samples and four kinds of cancer cell lines K562, PC-3M, HL-60 and MCF-7.


RESULTS
The total positive percentage of GM-CSF expression in prostate cancer was 79.2%. The positive percentages in the groups with Gleason score 2-4, 5-8, and 9-10 were 75%, 82.3% and 81.2% respectively. The four kinds of cancer cell lines had prominent GM-CSF receptor alpha subunit expression.


CONCLUSIONS
It suggests that both hyperplastic and neoplastic prostate tissues are responsive to GM-CSF and the extensive expression of GM-CSF receptors is an important characteristic of prostate cancer.
Chen
Zhaohui
Z
Institute of Urology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. zhaohuichen@hust.edu.cn
Yang
Yu
Y
Xiao
Yajun
Y
Zhao
Jun
J
D000818:Animals; D015153:Blotting, Western; D045744:Cell Line, Tumor; D018922:HL-60 Cells; D006801:Humans; D007150:Immunohistochemistry; D020014:K562 Cells; D008297:Male; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011817:Rabbits; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis*
D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor