Compatibility of sennoside A and B with pharmaceutical excipients.
This study reports the incompatibility of sennoside A and B with the following commonly used pharmaceutical excipients: stearic acid, sodium carbonate, glucose, lactose, propyl paraben, sodium carbonate, stearic acid, citric acid, PEG, and sorbitol. Drug-excipient compatibility was tested using thermal (DSC) and analytical (HPLC) methods of analysis. Compatibility evaluation showed that dry powder mixtures could be used to formulate sennoside A and B products. However, when mixed with water--propyl paraben, sodium carbonate, stearic acid, citric acid, PEG, and sugar derivatives such as lactose, glucose and sorbitol--should not be used in sennoside containing products.
Verloop
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Research Institute for Industrial Pharmacy, North-West University, Potchefstroom Campus, Potchefstroom, South Africa.
Marais
A F
AF
de Villiers
M M
MM
Liebenberg
W
W
D000880:Anthraquinones / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004344:Drug Incompatibility; D005079:Excipients; D011208:Powders; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D005079:Excipients; D011208:Powders; D000081226:Sennosides; D012676:Senna Extract