The efficacy of Sphaeranthus senegalensis Vaill extract against diarrhoea in rats.
The aqueous extract of Sphaeranthus senegalensis (Asteraceae) was investigated for anti-diarrhoeal activity in rats. Its effect on castor oil-induced diarrhoea and fluid accumulation and on gastrointestinal (charcoal meal) test was evaluated. Results showed that pre-treatment for 30 min with the extract at 50, 100 and 200 mg/kg, p.o. causes a dose-dependent protection against castor oil-induced diarrhoea and intraluminal fluid accumulation and inhibited gastrointestinal transit motility. These results suggest that the plant contain active constituents that may be useful against diarrhoea.
Adzu
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B
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, PMB 21 Abuja, Nigeria. bulusadzu@yahoo.com
Tarfa
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F
Amos
S
S
Gamaniel
K S
KS
D000818:Animals; D019659:Asteraceae; D002368:Castor Oil / Q000633:toxicity; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*; D005772:Gastrointestinal Transit / Q000187:drug effects / Q000502:physiology; D008297:Male; D016488:Medicine, African Traditional; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D002368:Castor Oil