title: Putting science into persistence, bioaccumulation, and toxicity evaluations.
abstract: In recent decades, advances have been made in the processes used to identify substances as persistent, bioaccumulative, and toxic (PBT). Key processes have been identified, and scientifically sound assessment methods have been developed. Regulatory agencies around the world have sought practical methods for implementing policies to protect both environment and human health. In the present paper, we review the various contributions that Mackay (in collaboration with his students and colleagues) has made to the development of scientifically sound methods for the identification of PBT substances and persistent organic pollutants. These contributions include efforts to clearly define the terminology and to develop scientifically defensible assessment models and evaluation frameworks.
authors.affiliation: Canadian Environmental Modelling Centre, Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J 7B8, Canada. ewebster@trentu.ca
authors.forename: Eva
authors.initials: E
authors.lastname: Webster
authors.forename: Christina E
authors.initials: CE
authors.lastname: Cowan-Ellsberry
authors.forename: Lynn
authors.initials: L
authors.lastname: McCarty
mesh_terms: D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000493:pharmacokinetics* / Q000633:toxicity*; D009930:Organic Chemicals; D018570:Risk Assessment; D009626:Terminology as Topic; D014018:Tissue Distribution
chemical_list: D004785:Environmental Pollutants; D009930:Organic Chemicals