Catalytic transformations with copper-metalated diglycine conjugates.
A series of copper-metalated, water-soluble bis-diglycine conjugates were synthesized and characterized through spectroscopic methods. These conjugates were evaluated for the cleavage of phosphodiester substrates, supercoiled plasmid relaxation in the presence of co-oxidants, and for the oxidation of a diphenolic substrate, 2,6-dimethoxyphenol. Appreciable rate enhancements were observed for these reactions and the oxidative nucleolytic cleavage activity and phenol oxidative coupling was presumably manifested via formation of reactive oxygen species.
Madhavaiah
C
C
Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur 208016, India.
Parvez
Masood
M
Verma
Sandeep
S
D020134:Catalytic Domain / Q000187:drug effects / Q000502:physiology; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D006033:Glycylglycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism; D015394:Molecular Structure; D010084:Oxidation-Reduction
D006033:Glycylglycine; D003300:Copper