What is in a filopodium? Starfish versus hedgehogs.
Many cell types can generate thin actin-based protrusive structures, which are often classified under the general term of 'filopodia'. However, a range of filopodia-like structures exists that differ both morphologically and functionally. In this brief review, we discuss the different types of filopodial structures, together with the actin-binding proteins and signalling pathways involved in their formation. Specifically, we highlight the differences between the filopodial extensions induced by the Rho GTPases Cdc42 and Rif.
Passey
S
S
Mammalian Cell Biology Laboratory, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. sam.passey@bristol.ac.uk
Pellegrin
S
S
Mellor
H
H
D000199:Actins / Q000378:metabolism; D000818:Animals; D006364:Hedgehogs; D011554:Pseudopodia / Q000737:chemistry / Q000502:physiology*; D013045:Species Specificity; D013215:Starfish; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D000199:Actins; D020764:cdc42 GTP-Binding Protein; D020741:rho GTP-Binding Proteins