title: A framework to study the cortical folding patterns.
abstract: This paper describes a decade-long research program focused on the variability of the cortical folding patterns. The program has developed a framework of using artificial neuroanatomists that are trained to identify sulci from a database. The framework relies on a renormalization of the brain warping problem, which consists in matching the cortices at the scale of the folds. Another component of the program is the search for the alphabet of the folding patterns, namely, a list of indivisible elementary sulci. The search relies on the study of the cortical folding process using antenatal imaging and on backward simulations of morphogenesis aimed at revealing traces of the embryologic dimples in the mature cortical surface. The importance of sulcal-based morphometry is illustrated by a simple study of the correlates of handedness on asymmetry indices. The study shows for instance that the central sulcus is larger in the dominant hemisphere.
authors.affiliation: Service Hospitalier Frédéric Joliot, CEA, 91401 Orsay cedex, France. mangin@shfj.cea.fr
authors.forename: J-F
authors.initials: JF
authors.lastname: Mangin
authors.forename: D
authors.initials: D
authors.lastname: Rivière
authors.forename: A
authors.initials: A
authors.lastname: Cachia
authors.forename: E
authors.initials: E
authors.lastname: Duchesnay
authors.forename: Y
authors.initials: Y
authors.lastname: Cointepas
authors.forename: D
authors.initials: D
authors.lastname: Papadopoulos-Orfanos
authors.forename: P
authors.initials: P
authors.lastname: Scifo
authors.forename: T
authors.initials: T
authors.lastname: Ochiai
authors.forename: F
authors.initials: F
authors.lastname: Brunelle
authors.forename: J
authors.initials: J
authors.lastname: Régis
mesh_terms: D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000254:growth & development / Q000502:physiology*; D003198:Computer Simulation; D016208:Databases, Factual; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D011247:Pregnancy; D009626:Terminology as Topic