title: Supratentorial cerebrospinal fluid production rate in healthy adults: quantification with two-dimensional cine phase-contrast MR imaging with high temporal and spatial resolution.
abstract: A method for objectively determining supratentorial cerebrospinal fluid (CSF) production rate is described. The method employs cine phase-contrast magnetic resonance imaging with high temporal and spatial resolution at the level of the aqueduct of Sylvius. Automatic encircling of the aqueduct was accomplished by using a pulsatility-based segmentation approach. Results in 23 healthy adults (18 men, five women; age range, 21-39 years) yielded an average CSF production rate of 305 microL/min +/- 145 (standard deviation); this rate is in good agreement with literature-reported values obtained with invasive ventriculolumbar perfusion measurements. Average operator imprecision was 23.1% if automatic segmentation was not used. The proposed method is potentially an effective means for measuring supratentorial CSF production rate in humans.
authors.affiliation: Department of Electrical Engineering, National Taiwan Univ, Taipei, Taiwan, ROC.
authors.forename: Teng-Yi
authors.initials: TY
authors.lastname: Huang
authors.forename: Hsiao-Wen
authors.initials: HW
authors.lastname: Chung
authors.forename: Ming-Yen
authors.initials: MY
authors.lastname: Chen
authors.forename: Lung-Hui
authors.initials: LH
authors.lastname: Giiang
authors.forename: Shy-Chyi
authors.initials: SC
authors.lastname: Chin
authors.forename: Chang-Shin
authors.initials: CS
authors.lastname: Lee
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Yi-Jui
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D000328:Adult; D002535:Cerebral Aqueduct; D002555:Cerebrospinal Fluid / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male