title: [Studies on the influencing factors on the drug release from sodium alginate matrices].
abstract: OBJECTIVE
  To investigate the in vitro influencing factors on drug release from matrices with sodium alginate as the hydrophilic polymer.
  
  
  METHODS
  Sodium alginate hydrophilic matrix tablets were prepared by direct compression method with theopylline as a model drug. The in vitro influencing factors on drug release behavior from matrices were studied by investigating the swelling, water uptake and erosion characteristics of pure sodium alginate matrices.
  
  
  RESULTS
  The results showed that drug release rate and drug release mechanism were both related to the viscosity of sodium alginate used in matrices, pH values and ionic strength of dissolution media and rotation speeds.
  
  
  CONCLUSIONS
  Sodium alginate can be tailor-made to suit the demands of applicants in sustained delivery systems as a good candidate of hydrophilic polymer.
authors.affiliation: School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang 110016, China. niesf77@163.com
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Nie
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Wu
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Liu
authors.forename: Hua-Wei
authors.initials: HW
authors.lastname: Jiang
authors.forename: Wei-San
authors.initials: WS
authors.lastname: Pan
mesh_terms: D000464:Alginates / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D020723:Glucuronic Acid / Q000008:administration & dosage* / Q000737:chemistry; D006603:Hexuronic Acids / Q000008:administration & dosage* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D012995:Solubility; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry; D014783:Viscosity
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D013607:Tablets; D020723:Glucuronic Acid; D013806:Theophylline