title: Preexercise metabolic alkalosis induced via bicarbonate ingestion accelerates Vo2 kinetics at the onset of a high-power-output exercise in humans.
abstract: The present study investigated the effect of preexercise metabolic alkalosis on the primary component of oxygen uptake (Vo(2)) kinetics, characterized by tau(1). Seven healthy physically active nonsmoking men, aged 22.4 +/- 1.8 (mean +/- SD) yr, maximum Vo(2) (Vo(2 max)) 50.4 +/- 4 ml.min(-1).kg(-1), performed two bouts of cycling, corresponding to 40 and 87% of Vo(2 max), lasting 6 min each, separated by a 20-min pause, once as a control study and a few days later at approximately 90 min after ingestion of 3 mmol/kg body wt of NaHCO(3). Blood samples for measurements of bicarbonate concentration and hydrogen ion concentration were taken from antecubital vein via catheter. Pulmonary Vo(2) was measured continuously breath by breath. The values of tau(1) were calculated by using six various approaches published in the literature. Preexercise level of bicarbonate concentration after ingestion of NaHCO(3) was significantly elevated (P < 0.01) compared with the control study (28.96 +/- 2.11 vs. 24.84 +/- 1.18 mmol/l; P < 0.01), and [H(+)] was significantly (P < 0.01) reduced (42.79 +/- 3.38 nmol/l vs. 46.44 +/- 3.51 nmol/l). This shift (P < 0.01) was also present during both bouts of exercise. During cycling at 40% of Vo(2 max), no significant effect of the preexercise alkalosis on the magnitude of tau(1) was found. However, during cycling at 87% of Vo(2 max), the tau(1) calculated by all six approaches was significantly (P < 0.05) reduced, compared with the control study. The tau(1) calculated as in Borrani et al. (Borrani F, Candau R, Millet GY, Perrey S, Fuchsloscher J, and Rouillon JD. J Appl Physiol 90: 2212-2220, 2001) was reduced on average by 7.9 +/- 2.6 s, which was significantly different from zero with both the Student's t-test (P = 0.011) and the Wilcoxon's signed-ranks test (P = 0.014).
authors.affiliation: Department of Muscle Physiology, AWF-Kraków, Al. Jana Pawla II 78, 31-571 Kraków, Poland. wfzoladz@cyf-kr.edu.pl
authors.forename: Jerzy A
authors.initials: JA
authors.lastname: Zoladz
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Szkutnik
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Duda
authors.forename: Joanna
authors.initials: J
authors.lastname: Majerczak
authors.forename: Bernard
authors.initials: B
authors.lastname: Korzeniewski
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000471:Alkalosis / Q000139:chemically induced* / Q000503:physiopathology*; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010807:Physical Endurance; D017693:Sodium Bicarbonate / Q000008:administration & dosage*
chemical_list: D017693:Sodium Bicarbonate; D010100:Oxygen