title: Class effect of angiotensin-converting enzyme inhibitors on prevention of myocardial infarction.
abstract: Angiotensin-converting enzyme (ACE) inhibitors differ in their affinity for tissue-bound ACE. It has been hypothesized that tissue ACE affinity might be responsible for some of the beneficial cardiovascular properties of ACE inhibitors. The present study examined this question and found no correlation between tissue ACE affinity and risk of first nonfatal myocardial infarction in patients who have hypertension.
authors.affiliation: Cardiovascular Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA.
authors.forename: William H
authors.initials: WH
authors.lastname: Sauer
authors.forename: Jefferson T
authors.initials: JT
authors.lastname: Baer
authors.forename: Jesse A
authors.initials: JA
authors.lastname: Berlin
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Kimmel
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000145:classification* / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000145:classification / Q000627:therapeutic use; D001552:Benzazepines / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D016022:Case-Control Studies; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D017706:Lisinopril / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000517:prevention & control*; D000077583:Quinapril; D044005:Tetrahydroisoquinolines / Q000627:therapeutic use; D016896:Treatment Outcome; D014481:United States
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D001552:Benzazepines; D002121:Calcium Channel Blockers; D044005:Tetrahydroisoquinolines; D017706:Lisinopril; D000077583:Quinapril; C044946:benazepril