The nucleolus and transcription of ribosomal genes.
Ribosome biogenesis is a highly dynamic, steady-state nucleolar process that involves synthesis and maturation of rRNA, its transient interactions with non-ribosomal proteins and RNPs and assembly with ribosomal proteins. In the few years of the 21st century, an exciting progress in the molecular understanding of rRNA and ribosome biogenesis has taken place. In this review, we discuss the recent results on the regulation of rRNA synthesis in relation to the functional organization of the nucleolus, and put an emphasis on the situation encountered in mammalian somatic cells.
Raska
Ivan
I
1st Faculty of Medicine, Charles University and Department of Cell Biology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 12800 Prague 2, Czech Republic. iraska@1f1.cuni.cz
Koberna
Karel
K
Malínský
Jan
J
Fidlerová
Helena
H
Masata
Martin
M
D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D002466:Cell Nucleolus / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D049109:Cell Proliferation; D002843:Chromatin / Q000502:physiology / Q000648:ultrastructure; D004275:DNA, Ribosomal / Q000235:genetics; D005786:Gene Expression Regulation; D020868:Gene Silencing / Q000502:physiology; D006801:Humans; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D012318:RNA Polymerase I / Q000378:metabolism; D012335:RNA, Ribosomal / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*
D002843:Chromatin; D004275:DNA, Ribosomal; D012335:RNA, Ribosomal; D012318:RNA Polymerase I