title: Asymmetric catalytic synthesis of enantiopure N-protected 1,2-amino alcohols.
abstract: [reaction: see text] The asymmetric aminolytic kinetic resolution (AKR) of racemic terminal epoxides using carbamates as the nucleophile catalyzed by (salen)Co(III) complex provides a practical and straightforward method for the synthesis of both aliphatic and aromatic N-Boc- or N-Cbz-protected 1,2-amino alcohols in almost enantiomerically pure form (ee >/= 99%). The AKR uses an easily accessible catalyst and inexpensive starting materials, and the reactions are conveniently carried out at room temperature under an air atmosphere.
authors.affiliation: Department of Organic Chemistry A. Mangini, University of Bologna v.le Risorgimento 4, 40136 Bologna, Italy. giuseppe.bartoli@unibo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bartoli
authors.forename: Marcella
authors.initials: M
authors.lastname: Bosco
authors.forename: Armando
authors.initials: A
authors.lastname: Carlone
authors.forename: Manuela
authors.initials: M
authors.lastname: Locatelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Melchiorre
authors.forename: Letizia
authors.initials: L
authors.lastname: Sambri