title: Gastric metaplasia and small bowel ulcerogenesis in a case of ulcerative jejunitis not related to celiac disease.
abstract: The possible relationship between gastric metaplasia and ulcerative lesions in an unusual case of ulcerative jejunitis not related to celiac disease and with extensive gastric metaplasia is discussed. Previous studies have described gastric metaplasia in duodenal ulcers on the basis of endoscopic data, and some authors maintain that acid secretion in metaplastic mucosa could represent a pathogenetic factor of ulcerogenesis, with a self-amplifying mechanism. In the absence of functional evidence, we could provide data, in a case of ulcerative jejunitis, about morphologic signs of acid secretion in gastric metaplastic epithelium using an antibody against HMFG-1, a good marker of acid-secreting fundic cells. Metaplastic areas demonstrated a focal positivity for HMFG-1, and these finding are suggestive of local acid secretion.
authors.affiliation: Department of Pathology, Ospedale S. Giovanni Antica Sede, Torino, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Canavese
authors.forename: V
authors.initials: V
authors.lastname: Villanacci
authors.forename: C
authors.initials: C
authors.lastname: Zambelli
authors.forename: A
authors.initials: A
authors.lastname: Bernardi
authors.forename: G
authors.initials: G
authors.lastname: Candelaresi
authors.forename: E
authors.initials: E
authors.lastname: Berardengo
authors.forename: M
authors.initials: M
authors.lastname: Pennazio
authors.forename: F P
authors.initials: FP
authors.lastname: Rossini
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D002446:Celiac Disease / Q000473:pathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D007579:Jejunal Diseases / Q000378:metabolism / Q000473:pathology*; D007583:Jejunum / Q000378:metabolism / Q000473:pathology*; D008679:Metaplasia / Q000473:pathology; D014456:Ulcer / Q000378:metabolism / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; C469215:pemtumomab