Neuropsychological correlates of diffusion tensor imaging in schizophrenia.
Patients with schizophrenia (n = 41) and healthy comparison participants (n = 46) completed neuropsychological measures of intelligence, memory, and executive function. A subset of each group also completed magnetic resonance diffusion tensor imaging (DTI) studies (fractional anisotropy and cross-sectional area) of the uncinate fasciculus (UF) and cingulate bundle (CB). Patients with schizophrenia showed reduced levels of functioning across all neuropsychological measures. In addition, selective neuropsychological-DTI relationships emerged. Among patients but not controls, lower levels of declarative-episodic verbal memory correlated with reduced left UF, whereas executive function errors related to performance monitoring correlated with reduced left CB. The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia.
Nestor
Paul G
PG
Clinical Neuroscience Division.
Kubicki
Marek
M
Clinical Neuroscience Division.
Gurrera
Ronald J
RJ
Clinical Neuroscience Division.
Niznikiewicz
Margaret
M
Clinical Neuroscience Division.
Frumin
Melissa
M
Clinical Neuroscience Division.
McCarley
Robert W
RW
0000-0001-5705-7495
Clinical Neuroscience Division.
Shenton
Martha E
ME
Clinical Neuroscience Division.
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology*; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology*; D013223:Statistics as Topic / Q000379:methods