Clinical results of proton beam therapy for skull base chordoma.
OBJECTIVE
To evaluate clinical results of proton beam therapy for patients with skull base chordoma.


METHODS
Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0-95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6-123.4 months).


RESULTS
The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery.


CONCLUSIONS
Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy.
Igaki
Hiroshi
H
Proton Medical Research Center, University Hospital, University of Tsukuba, Ibaraki, Japan. igaki-tky@umin.ac.jp
Tokuuye
Koichi
K
Okumura
Toshiyuki
T
Sugahara
Shinji
S
Kagei
Kenji
K
Hata
Masaharu
M
Ohara
Kiyoshi
K
Hashimoto
Takayuki
T
Tsuboi
Koji
K
Takano
Shingo
S
Matsumura
Akira
A
Akine
Yasuyuki
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002817:Chordoma / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061766:Proton Therapy; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000532:radiotherapy*; D011522:Protons
D011522:Protons