SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
A clinical strain of Klebsiella pneumoniae carried the bla(SHV-49) gene, encoding a novel inhibitor-resistant beta-lactamase of pI 7.6, derived from SHV-1 by the single substitution M69I. It also harbored a gene differing from bla(SHV-11) by four silent mutations and coding for a penicillinase. Both genes were chromosome located and might represent either a species-specific gene or an acquired resistance gene.
Dubois
Véronique
V
Laboratoire de Microbiologie, Faculté de Pharmacie, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. veronique.dubois@bacterio.u-bordeaux2.fr
Poirel
Laurent
L
Arpin
Corinne
C
Coulange
Laure
L
Bebear
Cécile
C
Nordmann
Patrice
P
Quentin
Claudine
C
D000368:Aged; D015139:Blotting, Southern; D024881:Drug Resistance, Bacterial; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007525:Isoelectric Focusing; D007700:Kinetics; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology*; D008297:Male; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D013530:Surgical Wound Infection / Q000382:microbiology; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000378:metabolism*
D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases; C494146:beta-lactamase SHV-49, Klebsiella pneumoniae