title: Myocardial infarction: optimization of inversion times at delayed contrast-enhanced MR imaging.
abstract: Seventeen patients underwent magnetic resonance (MR) imaging for myocardial viability with a protocol approved by the institutional review board and gave written informed consent. Breath-hold cine inversion-recovery segmented k-space true fast imaging with steady-state precession sequence, referred to as inversion time (TI) mapping, was performed to determine optimal TI for myocardial infarction inversion-recovery imaging. From TI mapping, optimal TI was 180-315 msec 10-15 minutes after administration of 0.15 mmol/kg of gadolinium-based contrast material. At that optimal TI, relative signal intensity of infarcted myocardium compared with uninfarcted myocardium was maximal (mean +/- standard deviation, 297.8% +/- 86.5), whereas signal-to-noise ratio of uninfarcted myocardium was minimal (4.5 +/- 1.2). When applied to conventional myocardial infarction inversion-recovery imaging, optimal TI resulted in nulling of signal intensity of uninfarcted myocardium in all patients and in excellent conspicuity of infarcted myocardium in all nine patients with visible infarction.
authors.affiliation: Department of Radiology-MRI, New York University Medical Center, 530 First Avenue, New York, NY 10016, USA.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gupta
authors.forename: Vivian S
authors.initials: VS
authors.lastname: Lee
authors.forename: Yiu-Cho
authors.initials: YC
authors.lastname: Chung
authors.forename: James S
authors.initials: JS
authors.lastname: Babb
authors.forename: Orlando P
authors.initials: OP
authors.lastname: Simonetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002306:Cardiac Volume; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA