title: Is the regulation of galactose 1-phosphate tuned against gene expression noise?
abstract: The average number of mRNA molecules per active gene in yeast can be remarkably low. Consequently, the relative number of copies of each transcript per cell can vary greatly from moment to moment. When these transcripts are encoding metabolic enzymes, how do the resulting variations in enzyme concentrations affect the regulation of metabolic intermediates? Using a kinetic model of galactose utilization in yeast, we analysed the transmission of noise from transcription and translation on metabolic intermediate regulation. In particular, the effect of the kinetic properties of the galactose-1-phosphate uridylyltransferase reaction on the transmission of noise was analysed.
authors.affiliation: Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: de Atauri
authors.forename: David
authors.initials: D
authors.lastname: Orrell
authors.forename: Stephen
authors.initials: S
authors.lastname: Ramsey
authors.forename: Hamid
authors.initials: H
authors.lastname: Bolouri
mesh_terms: D005690:Galactose / Q000378:metabolism; D005695:Galactosephosphates / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D007700:Kinetics; D014176:Protein Biosynthesis / Q000235:genetics; D012331:RNA, Fungal / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase / Q000378:metabolism*
chemical_list: D005695:Galactosephosphates; D012331:RNA, Fungal; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; C029973:galactose-1-phosphate; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase; D005690:Galactose