Ancistroheynine B and two further 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus heyneanus Wall.
A new axially chiral naphthylisoquinoline alkaloid, ancistroheynine B (7), has been isolated from the leaves of the Indian liana Ancistrocladus heyneanus Wall., along with two known related alkaloids, ancistrocladidine (3) and ancistrotanzanine C (6), which are 7,3'-coupled, too. The structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Biological activities of ancistroheynine B against the pathogens of malaria, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated.
Bringmann
Gerhard
G
Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany. bringmann@chemie.uni-wuerzburg.de
Dreyer
Michael
M
Michel
Manuela
M
Tayman
Francis S K
FS
Brun
Reto
R
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification; D007546:Isoquinolines / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000302:isolation & purification; D009284:Naphthols / Q000302:isolation & purification
D000470:Alkaloids; D000981:Antiprotozoal Agents; D007546:Isoquinolines; D009281:Naphthalenes; D009284:Naphthols; C494932:ancistroheynine B; C486998:ancistrotanzanine C; C451486:ancistrocladidine