title: [On the role of GABA in anxiety and depression].
abstract: Data on the role of gamma-aminobutyric acid (GABA) in pathogenesis of anxiety and depression are critically assessed. Clinical and experimental results indicative of an important role of GABA as the neurotransmitter involved in these mental states and their integration within a common pathogenic process are considered. The general neurochemical, pharmacological, and neurophysiological aspects of anxiety and depression are analyzed in the context of GABAergic system involvement in this process and the possibility of using GABAergic agents for the therapy of various related disorders.
authors.forename: A V
authors.initials: AV
authors.lastname: Kaluev
authors.forename: D J
authors.initials: DJ
authors.lastname: Nutt
mesh_terms: D001007:Anxiety / Q000209:etiology* / Q000628:therapy; D003863:Depression / Q000209:etiology* / Q000628:therapy; D018682:GABA Agents / Q000627:therapeutic use; D006801:Humans; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D018682:GABA Agents; D005680:gamma-Aminobutyric Acid