title: Hyrtiosenolides A and B, two new sesquiterpene gamma-methoxybutenolides and a new sterol from a Red Sea sponge Hyrtios species.
abstract: Two new sesquiterpene gamma-methoxybutenolides, hyrtiosenolides A (1) and B (2), together with a new 4alpha-methyl polyoxygenated steroid, hyrtiosterol (3), were isolated from a Red Sea sponge, Hyrtios species. Their structures were elucidated by analysis of their 1D and 2D NMR spectra and HRFABMS. Compounds 1 and 2 showed weak antibacterial activity against Escherichia coli.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
authors.forename: Diaa T A
authors.initials: DT
authors.lastname: Youssef
authors.forename: Abdel Nasser B
authors.initials: AN
authors.lastname: Singab
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000818:Animals; D004926:Escherichia coli / Q000187:drug effects*; D019156:Indian Ocean; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes; D013261:Sterols; C493703:hyrtiosenolide A; C493705:hyrtiosenolide B; C493704:hyrtiosterol