Aurora kinases in spindle assembly and chromosome segregation.
The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation.
Ducat
Daniel
D
Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, MD 21210, USA.
Zheng
Yixian
Y
D000818:Animals; D064107:Aurora Kinase B; D064127:Aurora Kinases; D020090:Chromosome Segregation; D048749:Cytokinesis / Q000502:physiology; D006801:Humans; D008938:Mitosis / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology
C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases