Novel formation and use of a Nicholas carbocation in the synthesis of highly substituted tetrahydrofurans.
The first formation of a Nicholas carbocation through cleavage of a carbon-carbon sigma bond has allowed the preparation of highly substituted tetrahydrofurans in a formal dipolar cycloaddition reaction.
Christie
Steven D R
SD
Department of Chemistry, Loughborough University, Loughborough, UK LE11 3TU. s.d.christie@lboro.ac.uk
Davoile
Ryan J
RJ
Elsegood
Mark R J
MR
Fryatt
Ross
R
Jones
Raymond C F
RC
Pritchard
Gareth J
GJ
D003035:Cobalt / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D005663:Furans; D009942:Organometallic Compounds; D003035:Cobalt