title: The ketogenic diet does not alter brain expression of orexigenic neuropeptides.
abstract: Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ hybridization revealed no effect of the KD on NPY or galanin mRNA expression, suggesting that increased expression of NPY and galanin do not contribute to the anticonvulsant effect of the KD.
authors.affiliation: Department of Human Genetics, Emory University School of Medicine, Whitehead Building, Suite 301, 615 Michael Street, Atlanta, GA 30322, USA.
authors.forename: Kroshona
authors.initials: K
authors.lastname: Tabb
authors.forename: Patricia
authors.initials: P
authors.lastname: Szot
authors.forename: Sylvia S
authors.initials: SS
authors.lastname: White
authors.forename: L Cameron
authors.initials: LC
authors.lastname: Liles
authors.forename: David
authors.initials: D
authors.lastname: Weinshenker
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D004827:Epilepsy / Q000178:diet therapy*; D019004:Galanin / Q000096:biosynthesis*; D017403:In Situ Hybridization; D007659:Ketones / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009478:Neuropeptide Y / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012640:Seizures / Q000139:chemically induced / Q000178:diet therapy
chemical_list: D007659:Ketones; D009478:Neuropeptide Y; D012333:RNA, Messenger; D019004:Galanin; D020155:3-Hydroxybutyric Acid