title: Corneal and epithelial thickness changes after 4 weeks of overnight corneal refractive therapy lens wear, measured with optical coherence tomography.
abstract: OBJECTIVE
  To investigate thickness changes of the total cornea and epithelium across the horizontal corneal meridian after 4 weeks of overnight corneal refractive therapy (CRT) rigid contact lens (Paragon Vision Sciences, Mesa, AZ) wear.
  
  
  METHODS
  Thirty subjects were fitted with CRT contact lenses (Dk/t = 67), which were worn overnight for 4 weeks. Corneal thickness was measured at nine locations along the horizontal meridian by using optical coherence tomography (OCT) before lens insertion in the evening. Corneal thickness was measured the next morning immediately after lens removal and 1, 3, 7, and 14 hours later. This was repeated on days 4, 10, and 28 of the study and then 3 days after discontinuing lens wear.
  
  
  RESULTS
  Twenty-three subjects completed the study. At lens removal on day 1, the central and paracentral cornea swelled by 4.9% and 6.2%, respectively (both P = 0.000). The central epithelium thinned by 7.3%, and the mid peripheral epithelium thickened by 13% (both P = 0.000). Corneal swelling recovered throughout the day, with most of the deswelling taking place within the first 3 hours after lens removal. Maximal central epithelial thinning reached 13.5% by day 4. Three days after the study completion, corneal and epithelial thickness had recovered to baseline values.
  
  
  CONCLUSIONS
  This study shows that CRT lenses induce differential overnight swelling across the cornea, with rapid deswelling during the day. Central epithelial thinning and paracentral thickening occurs, with recovery 3 days after discontinuation of lens wear.
authors.affiliation: Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, N2L 3G1 Canada.
authors.forename: Sameena
authors.initials: S
authors.lastname: Haque
authors.forename: Desmond
authors.initials: D
authors.lastname: Fonn
authors.forename: Trefford
authors.initials: T
authors.lastname: Simpson
authors.forename: Lyndon
authors.initials: L
authors.lastname: Jones
mesh_terms: D000328:Adult; D001837:Body Weights and Measures; D003261:Contact Lenses; D003315:Cornea / Q000473:pathology*; D003941:Diagnostic Techniques, Ophthalmological; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000473:pathology / Q000628:therapy*; D041623:Tomography, Optical Coherence / Q000379:methods