title: Phosphaadamantanes as ligands for palladium catalyzed cross-coupling chemistry: library synthesis, characterization, and screening in the Suzuki coupling of alkyl halides and tosylates containing beta-hydrogens with boronic acids and alkylboranes.
abstract: A 15-member library of phosphaadamantane ligands has been prepared via P-arylation of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phosphaadamantane. Screening of this tertiary phosphine collection has allowed for the rapid determination of the most suitable ligand, specifically 1,3,5,7-tetramethyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane, for facilitating Suzuki-type couplings of alkyl halides or tosylates containing beta-hydrogens with either boronic acids or alkylboranes.
authors.affiliation: Department of Chemistry, McMaster University, Hamilton, Ontario L8S 4M1, Canada.
authors.forename: Tim
authors.initials: T
authors.lastname: Brenstrum
authors.forename: David A
authors.initials: DA
authors.lastname: Gerristma
authors.forename: George M
authors.initials: GM
authors.lastname: Adjabeng
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Frampton
authors.forename: James
authors.initials: J
authors.lastname: Britten
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Robertson
authors.forename: James
authors.initials: J
authors.lastname: McNulty
authors.forename: Alfredo
authors.initials: A
authors.lastname: Capretta