title: TGFBR1*6A is not associated with prostate cancer in men of European ancestry.
abstract: The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case-control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the (*)6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid, St Louis, M) 63110, USA. bks@themfs.wustl.edu
authors.forename: B K
authors.initials: BK
authors.lastname: Suarez
authors.forename: P
authors.initials: P
authors.lastname: Pal
authors.forename: C H
authors.initials: CH
authors.lastname: Jin
authors.forename: R
authors.initials: R
authors.lastname: Kaushal
authors.forename: G
authors.initials: G
authors.lastname: Sun
authors.forename: L
authors.initials: L
authors.lastname: Jin
authors.forename: B
authors.initials: B
authors.lastname: Pasche
authors.forename: R
authors.initials: R
authors.lastname: Deka
authors.forename: W J
authors.initials: WJ
authors.lastname: Catalona
mesh_terms: D030201:Activin Receptors, Type I / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D044465:White People
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human