title: Fructose-2,6-bisphosphate: a traffic signal in plant metabolism.
abstract: Fructose-2,6-bisphosphate (Fru-2,6-P(2)) regulates key reactions of the primary carbohydrate metabolism in all eukaryotes. In plants, Fru-2,6-P(2) coordinates the photosynthetic carbon flux into sucrose and starch biosynthesis. The use of transgenic plants has allowed the regulatory models to be tested by modifying the Fru-2,6-P(2) levels and the enzymes regulated by Fru-2,6-P(2). Genes for the bifunctional plant enzyme that synthesizes and degrades Fru-2,6-P(2) have been isolated and molecular characterization has provided new insight into structure and molecular regulation of the enzyme. Advances in Fru-2,6-P(2) physiology and molecular biology are discussed. These advances have not only enlightened in vivo operation of Fru-2,6-P(2) but also revealed that the Fru-2,6-P(2) regulatory system is highly complex and interacts with other regulatory mechanisms.
authors.affiliation: Plant Biochemistry Laboratory, Center for Molecular Plant Physiology, Department of Plant Biology, Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK-1871 Frederiksberg, Denmark. thni@kvl.dk
authors.forename: Tom Hamborg
authors.initials: TH
authors.lastname: Nielsen
authors.forename: Jesper Henrik
authors.initials: JH
authors.lastname: Rung
authors.forename: Dorthe
authors.initials: D
authors.lastname: Villadsen
mesh_terms: D005635:Fructosediphosphates / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D025481:Phosphofructokinase-2 / Q000378:metabolism; D010802:Phylogeny; D010944:Plants / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D005635:Fructosediphosphates; C027652:fructose 2,6-diphosphate; D025481:Phosphofructokinase-2