[The effect of mexidol on the process of glycolysis in rats under acute stress conditions].
Pretreatment with mexidol (100 mg/kg) protected white male rats (n = 29) under the conditions of acute (3 h) immobilization stress. This was evidenced by monitoring of the levels of glucose, pyruvic, and lactic acid in the rat brain, liver, spleen, thymus, and blood serum. In both brain and peripheral organs, mexidol the shifted the equilibrium toward pyruvate--an energetically more favorable substrate of enzymatic oxidation.
Deviatkina
T A
TA
Vazhnichaia
E M
EM
Lutsenko
R V
RV
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D005947:Glucose / Q000032:analysis; D006019:Glycolysis / Q000187:drug effects*; D019344:Lactic Acid / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D010847:Picolines / Q000494:pharmacology*; D019289:Pyruvic Acid / Q000032:analysis; D051381:Rats; D013154:Spleen / Q000737:chemistry / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*; D013950:Thymus Gland / Q000737:chemistry / Q000378:metabolism
D001786:Blood Glucose; D010847:Picolines; C070020:emoxypine succinate; D019344:Lactic Acid; D019289:Pyruvic Acid; D005947:Glucose