title: A mild acute compression induces neurapraxia in rat sciatic nerve.
abstract: The pressure that induces neurapraxia in rat remains unrevealed. To determine the appropriate force to induce neurapraxia, two types of clips were applied to the sciatic nerve and were evaluated with functional, electrophysiological, and histological examinations. With a compression of 60 g/mm2, walking track analysis showed complete sciatic nerve paralysis one day postoperatively, but became normal in 14 days. Electrophysiologically, complete conduction block occurred one day post operatively, whereas the motor conduction velocity (MCV) below the compression site remained normal. Histologically, only limited signs of Wallerian degeneration were seen. The model in this study exhibited the features of neurapraxia.
authors.affiliation: Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan. takao@tm.hama-med.ac.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Omura
authors.forename: Michio
authors.initials: M
authors.lastname: Sano
authors.forename: Kumiko
authors.initials: K
authors.lastname: Omura
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Akira
authors.initials: A
authors.lastname: Nagano
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004594:Electrophysiology; D005260:Female; D009408:Nerve Compression Syndromes / Q000473:pathology / Q000503:physiopathology*; D009409:Nerve Crush / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D009431:Neural Conduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012584:Sciatic Nerve / Q000293:injuries / Q000473:pathology / Q000503:physiopathology*; D016037:Single-Blind Method; D013525:Surgical Instruments