Comparison of two combined vaccines against typhoid fever and hepatitis A in healthy adults.
A prospective, randomised, observer-blind, comparative study was performed in healthy adults with a new hepatitis A/typhoid combined vaccine, Viatim, and the marketed Hepatyrix vaccine. Both vaccines induced high levels of protective antibodies, but typhoid responses were higher and hepatitis A responses more rapid with Viatim compared with Hepatyrix. Both vaccines were well tolerated, no serious adverse events (SAEs) occurred, but more Viatim vaccinees had more mild or moderate local reactions (82.7%) than Hepatyrix (53.1%, p < 0.001). In this direct comparison Viatim induced more local reactions, but elicited a more rapid and higher immune response to both antigens than Hepatyrix.
Beeching
Nicholas J
NJ
Clinical Research Group, Liverpool School of Tropical Medicine, UK.
Clarke
Paul D
PD
Kitchin
Nicholas R E
NR
Pirmohamed
Jackie
J
Veitch
Keith
K
Weber
Françoise
F
D000293:Adolescent; D000328:Adult; D006506:Hepatitis A / Q000276:immunology / Q000517:prevention & control; D022362:Hepatitis A Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D014435:Typhoid Fever / Q000276:immunology / Q000517:prevention & control; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage / Q000276:immunology*; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
D022362:Hepatitis A Vaccines; D014436:Typhoid-Paratyphoid Vaccines; D017778:Vaccines, Combined