Rationally designed ligands for asymmetric iridium-catalyzed hydrogenation of olefins.
A new class of chiral N,P-ligands for the Ir-catalyzed asymmetric hydrogenation of aryl alkenes has been developed. These new ligands proved to be highly efficient and tolerates a broad range of substrates. The enantiomeric excesses are in the range of the best ever reported. The results can be rationalized with the proposed selectivity model.
Källström
Klas
K
Organic Chemistry, Department of Chemistry, Uppsala University, Box 599, 751 24, Uppsala, Sweden.
Hedberg
Christian
C
Brandt
Peter
P
Bayer
Annette
A
Andersson
Pher G
PG