Highly (Z)-selective synthesis of beta-monosubstituted alpha,beta-unsaturated cyanides using the peterson reaction.
[reaction: see text] The Peterson reaction between (t-BuO)Ph(2)SiCH(2)CN and various aldehydes furnishes the corresponding beta-monosubstituted alpha,beta-unsaturated cyanides with high Z selectivity (Z:E = 92:8 to >98:2).
Kojima
Satoshi
S
Department of Chemistry, Graduate School of Science, and Center of Quantum Life Sciences, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan. skojima@hiroshima-u.ac.jp
Fukuzaki
Tomohide
T
Yamakawa
Atsushi
A
Murai
Yutaka
Y