[Glucose attenuating local anesthetic-induced hemolysis].
BACKGROUND
The effect of glucose on local anesthetic-induced neural damage has not been fully studied. We examined the effect of glucose on hemolysis induced by local anesthetics.


METHODS
The mean EC50 values (the local anesthetic level that causes destruction of half of the red blood cells in vitro) of lidocaine HCl, tetracaine HCl and dibucaine HCl were determined with 0% and 7.5% glucose contained in Krebs solution at pH 6.4.


RESULTS
The mean EC50 values of lidocaine HCl, tetracaine HCl, and dibucaine HCl in 0%-glucose Krebs solution were 6.51%, 0.45%, 0.17%, respectively, which increased significantly to 7.05%, 0.64% and 0.23%, in 7.5% glucose Krebs solution at pH 6.4.


CONCLUSIONS
Glucose may have a protective role in local anesthetic-induced neural damage.
Katsuki
Hiroshi
H
Department of Anesthesiology, Miyazaki Shigun Ishikai Hospital, Miyazaki 880-0834.
Tateyama
Shingo
S
Hidaka
Nami
N
Yano
Takeshi
T
Ibusuki
Shoichiro
S
Takasaki
Mayumi
M
D000779:Anesthetics, Local / Q000009:adverse effects* / Q000037:antagonists & inhibitors*; D003992:Dibucaine / Q000009:adverse effects* / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008012:Lidocaine / Q000009:adverse effects* / Q000037:antagonists & inhibitors*; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000517:prevention & control; D013748:Tetracaine / Q000009:adverse effects* / Q000037:antagonists & inhibitors*
D000779:Anesthetics, Local; D013748:Tetracaine; D008012:Lidocaine; D005947:Glucose; D003992:Dibucaine