[Impaired glucose tolerance and the risk of cardiovascular death].
Hyperglycemia and type 2 diabetes are an independent risk factor of cardiovascular (CV) disorders of atherosclerotic etiology. Proatherosclerotic sequelae of hyperglycemia comprise oxidative stress caused by increased production of free radicals, activation of leucocyte-endothelium interactions, and protein glycosylation. According to current reccomendations diabetes is diagnosed when plasma glucose concentration exceeds 10.0 mmol/L in 2-hour standard oral glucose tolerance test, whereas the result of 6.7-9.9 mmol/L speaks for asymptomatic impaired glucose tolerance (IGT) which does not require treatment. However, several data sets and their meta-analyses are suggestive of that not only diabetes, but also IGT is associated with significantly increased risk of cardiovascular death. A recent report indicated also that glycosylated hemoglobin HbA(1c) level is a continuous and very strong risk factor for CV death. In view of these data therapeutic interventions for IGT shall be considered.
Grieb
Paweł
P
Pracownia Farmakologii Doświadczalnej, Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN w Warszawie. pgrieb@cmdik.pan.pl
D003324:Coronary Artery Disease / Q000378:metabolism / Q000401:mortality* / Q000503:physiopathology*; D018149:Glucose Intolerance; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D012307:Risk Factors
D006442:Glycated Hemoglobin