title: Rational design of CH/pi interaction sites in a basic resolving agent.
abstract: A novel synthetic basic resolving agent, cis-1-aminobenz[f]indan-2-ol (ABI), was rationally designed by introducing effective CH/pi interaction sites to cis-1-aminoindan-2-ol (AI), whose chiral recognition ability has been reported from our laboratory. ABI was applicable to a wide variety of racemic arylalkanoic acids and showed moderate to excellent chiral recognition ability, which was obviously higher than that of AI. The fundamental and important role of CH/pi interactions, such as tunable CH(sp(2))/pi and CH(sp(3))/pi interactions, in the chiral recognition by ABI was revealed by X-ray crystallographic study.
authors.affiliation: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Toshie
authors.initials: T
authors.lastname: Kurasawa
authors.forename: Kazushi
authors.initials: K
authors.lastname: Kinbara
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Saigo