title: [Discovery of endothelin and its significance].
authors.affiliation: Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba.
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Goto
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001381:Azepines; D002318:Cardiovascular Diseases / Q000209:etiology*; D015195:Drug Design; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000493:pharmacokinetics / Q000494:pharmacology / Q000502:physiology; D016232:Endothelins / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology; D006801:Humans; D007189:Indans; D007211:Indoles; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic; D011743:Pyrimidines; D017466:Receptors, Endothelin / Q000502:physiology; D013449:Sulfonamides; D014661:Vasoconstriction / Q000187:drug effects; D000096926:Benzenesulfonamides
chemical_list: D001381:Azepines; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D016232:Endothelins; D007189:Indans; D007211:Indoles; D010456:Peptides, Cyclic; D011743:Pyrimidines; D017466:Receptors, Endothelin; D013449:Sulfonamides; C087551:1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-; C079574:FR 139317; C083751:Ro 46-2005; D000096926:Benzenesulfonamides; C088196:TAK 044; C072247:cyclo(Trp-Asp-Pro-Val-Leu)