Testicular microlithiasis: an unreported feature of McCune-Albright syndrome in males.
OBJECTIVE
To ascertain the incidence of testicular microlithiasis (TM) in boys with McCune-Albright syndrome (MAS).


METHODS
Study population consisted of 8 boys with MAS whose medical records were reviewed with emphasis on their past genitourinary histories. All of the boys underwent a clinical and ultrasonographic (US) scanning of the scrotal and inguinal regions. US results in boys with MAS were compared with those obtained in two control populations consisting of 20 healthy subjects and 12 boys with idiopathic and untreated central precocious puberty (CPP).


RESULTS
Clinical examination revealed urological abnormalities in no patients, whereas US showed a typical picture of TM in 5 of 8 boys. TM was observed in none of the subjects belonging to control populations (v=15.2 and 11.3, respectively; P <.001).


CONCLUSIONS
In a series of 8 boys with MAS we demonstrated a high prevalence (62%) of TM that was associated with neither malignant nor nonmalignant conditions. This finding is unlikely to be only occasional, considering the very low prevalence of TM reported until now in healthy children and young adults and in our results in control populations. TM may be another marker for MAS.
Wasniewska
Malgorzata
M
Department of Pediatrics, Universities of Messina, Pisa, and Milan, Reginal Margherita Hospital of Turin, Italy. wasniewska@yahoo.it
De Luca
Filippo
F
Bertelloni
Silvano
S
Matarazzo
Patrizia
P
Weber
Giovanna
G
Crisafulli
Giuseppe
G
Valenzise
Mariella
M
Lala
Roberto
R
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D020347:Lithiasis / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D011629:Puberty, Precocious / Q000000981:diagnostic imaging / Q000209:etiology; D013733:Testicular Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D013737:Testis / Q000000981:diagnostic imaging; D014463:Ultrasonography