[Significance of alpha1-antichymotrypsin (ACT) in early diagnosis of intra-amniotic infection (IAI)].
The aim of the present study was to determine the level and pattern of alpha1-antichymotrypsin (ACT) in women with intra-amniotic infection (IAI). The ACT level was determined using rocket immunoelectrophoresis according to Laurell. In determining of ACT isoform level the crossed immunoelectrophoresis method by Bøg-Hansen was used. In our study the ACT level was statistically higher in the IAI group if compared to the group of healthy pregnant women. We have also observed the higher level of A4 isoform of ACT in the group with IAI if compared to the controls. We have concluded that ACT A4 isoform could be the good marker in early detection of IAI.
Kopyra
Paweł
P
Klinika Perinatologii Katedry Ginekologii i Perinatologii AM w Poznaniu.
Seremak-Mrozikiewicz
Agnieszka
A
Nowak-Markwitz
Ewa
E
Drews
Krzysztof
K
D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry* / Q000201:enzymology; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000201:enzymology*; D012307:Risk Factors
D015415:Biomarkers; D002918:Chymotrypsin; C117608:alpha-chymotrypsin