title: A double-blind combination study of clonazepam with sertraline in obsessive-compulsive disorder.
abstract: This double blind, randomized, parallel, placebo-controlled study investigates whether clonazepam accelerates and/ or increases the overall response in patients with obsessive compulsive disorder (OCD) who are treated with sertraline. Thirty-seven patients were randomized with 20 in the sertraline and clonazepam group and 17 in the sertraline and placebo groups. Male and female outpatients, age 18-65 years, met criteria for a primary diagnosis of obsessive compulsive disorder according to DSM-IV, as determined by the structured clinical MINI interview. Appropriate safety and efficacy parameters were measured throughout the study. The determination of efficacy was based primarily on changes from baseline to the last observation taken through week 12. Analysis revealed no significant difference between groups at endpoint on the main scale.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Box 3516, Durham, NC, 27710, USA. crock006@mc.duke.edu
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Crockett
authors.forename: Erik
authors.initials: E
authors.lastname: Churchill
authors.forename: Jonathan R T
authors.initials: JR
authors.lastname: Davidson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D002998:Clonazepam; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline