title: Endoscopic therapy for gastroesophageal reflux disease: can it replace antireflux surgery?
abstract: This article addresses emergent endoluminal technologies currently available for the treatment of gastroesophageal reflux disease (GERD) and compares it to the laparoscopic Nissen fundoplication. To date the mainstay of GERD therapy has been achieved with either open or laparoscopic fundoplication or life-long medical treatment. Endoluminal treatment modalities attempt to augment the gastroesophageal junction (GEJ) function by various techniques. We searched the Medline database from 1980 to 2004 for studies on endoscopic GERD techniques and laparoscopic fundoplications. Product investigators were contacted for data presented in abstract form only. Endoluminal management of GERD include using radiofrequency energy, injection of biocompatible polymers and endoluminal sutures to alter the GEJ and reduce reflux. Early results while encouraging, should be evaluated thoroughly and with caution before widespread use can be advocated. Endoscopic treatment of GERD has future promise, however, more experience and perhaps further refinement in techniques and technology must occur before widespread clinical application can be encouraged.
authors.affiliation: Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA. doleynik@unmc.edu
authors.forename: D
authors.initials: D
authors.lastname: Oleynikov
authors.forename: B
authors.initials: B
authors.lastname: Oelschlager
authors.forename: J
authors.initials: J
authors.lastname: Dibaise
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D019723:Endoscopes; D016145:Endoscopy, Digestive System; D005500:Follow-Up Studies; D005544:Forecasting; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D010535:Laparoscopy; D015337:Multicenter Studies as Topic; D010215:Papio; D011145:Polyvinyls / Q000008:administration & dosage; D011446:Prospective Studies; D012008:Recurrence; D013525:Surgical Instruments; D013536:Suture Techniques; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer