title: A case of nasal leiomyosarcoma: the first comparative genomic hybridization analysis.
abstract: Leiomyosarcomas are rare in the head and neck region. The treatment of choice is surgical resection. We present a case of leiomyosarcoma in a 50-year-old female patient, arising from the inferior turbinate. The tumor was resected by a transnasal microendoscopic approach and no evidence for tumor recurrence was found during an endoscopic and radiologic follow-up of two years. Cytogenetic analysis by means of comparative genomic hybridization revealed chromosomal gains at 4p13p15, 6p21p22, 7q22qter, 9q22qter and chromosomal losses at 10q22qter and 19p12p13.1. With augmented experience, the transnasal approach may be appropriate to resect circumscribed malignant tumors located in the nasal cavity.
authors.affiliation: Department of Otolaryngology, Head & Neck Surgery, University Hospital Homburg, Saar, Germany.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Peters
authors.forename: Christian
authors.initials: C
authors.lastname: Brunner
authors.forename: Steffi
authors.initials: S
authors.lastname: Urbschat
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schick
mesh_terms: D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed