title: Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica.
abstract: The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC(50) values of 7.9+/-1.1 and 5.3+/-0.7 microg/ml, respectively. From this extract, a new chalcone, 2',3,4,4'-tetrahydroxy-5-prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'-prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti-plasmodial principles. The structures were determined on the basis of spectroscopic evidence.
authors.affiliation: Department of Chemistry, University of Nairobi, P.O. Box 30197, Chiromo Road, Nairobi, Kenya. ayenesew@uonbi.ac.ke
authors.forename: Abiy
authors.initials: A
authors.lastname: Yenesew
authors.forename: Martha
authors.initials: M
authors.lastname: Induli
authors.forename: Solomon
authors.initials: S
authors.lastname: Derese
authors.forename: Jacob O
authors.initials: JO
authors.lastname: Midiwo
authors.forename: Matthias
authors.initials: M
authors.lastname: Heydenreich
authors.forename: Martin G
authors.initials: MG
authors.lastname: Peter
authors.forename: Hoseah
authors.initials: H
authors.lastname: Akala
authors.forename: Julia
authors.initials: J
authors.lastname: Wangui
authors.forename: Pamela
authors.initials: P
authors.lastname: Liyala
authors.forename: Norman C
authors.initials: NC
authors.lastname: Waters
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000302:isolation & purification; D047188:Chalcones; D004895:Erythrina / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: C495306:2',3,4,4'-tetrahydroxy-5-prenylchalcone; C495307:4',7-dihydroxy-3'-methoxy-5'-prenylflavanone; D000962:Antimalarials; D047188:Chalcones; D005419:Flavonoids; D002599:Chalcone