title: Paraneoplastic limbic encephalitis: diagnostic relevance of CSF analysis and total body PET scanning.
abstract: We report two cases of paraneoplastic limbic encephalitis (PLE) that differed in their clinical patterns, the underlying tumours, and the associated paraneoplastic antibodies. The first patient was a young adult male, with anti-MA-2 antibodies and testicular tumour. The clinical picture was restricted to limbic involvement. The second patient was a 56-year old, female heavy smoker; with seizures and depression, but also vertigo and diplopia. A low level of serum anti-Hu antibodies led to the detection of a small cell lung carcinoma by total body PET-scanning. In both cases, intrathecal synthesis of CSF oligoclonal IgG bands and of the corresponding paraneoplastic antibodies was demonstrated.
authors.affiliation: Department of Neurology and Laboratory of Neurochemistry, Université catholique de Louvain et Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels.
authors.forename: J
authors.initials: J
authors.lastname: Dreessen
authors.forename: A P
authors.initials: AP
authors.lastname: Jeanjean
authors.forename: C J M
authors.initials: CJ
authors.lastname: Sindic
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*