Adrenomedullin receptors: pharmacological features and possible pathophysiological roles.
Three receptor activity modifying proteins (RAMPs) chaperone calcitonin-like receptor (CLR) to the cell surface. RAMP2 enables CLR to form an adrenomedullin (AM)-specific receptor that is sensitive to AM-(22-52) (AM(1) receptor). RAMP3 enables CLR to form an AM receptor sensitive to both calcitonin gene-related peptide (CGRP)-(8-37) and AM-(22-52) (AM(2) receptor), though rat and mouse AM(2) receptors show a clear preference for CGRP alpha-(8-37) over AM-(22-52). RAMP1 enables CRL to form the CGRP-(8-37)-sensitive CGRP(1) receptor, which can also be activated by higher concentrations of AM. Here we review the available information on the pharmacological features and possible pathophysiological roles of the aforementioned AM receptors.
Kuwasako
Kenji
K
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. kuwasako@fc.miyazaki-med.ac.jp
Cao
Yuan-Ning
YN
Nagoshi
Yasuko
Y
Kitamura
Kazuo
K
Eto
Tanenao
T
D000818:Animals; D005544:Forecasting; D006801:Humans; D011485:Protein Binding; D012333:RNA, Messenger / Q000378:metabolism; D058265:Receptors, Adrenomedullin; D018003:Receptors, Calcitonin / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism*
D012333:RNA, Messenger; D058265:Receptors, Adrenomedullin; D018003:Receptors, Calcitonin; D018000:Receptors, Peptide