Mass spectrometry in aging research.
This review covers the application of mass spectrometric techniques to aging research. Modern proteomic strategies will be discussed as well as the targeted analysis of specific proteins for the correlation of post-translational modifications with protein function. Selected examples will show both the power and also current limitations of the respective techniques. Experimental results and strategies are discussed in view of current theories of the aging process.
Schöneich
Christian
C
Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA.
D000375:Aging / Q000502:physiology*; D000818:Animals; D035843:Biomedical Research; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D040901:Proteomics