title: A novel solution for the time-dependent probability of gene fixation or loss under natural selection.
abstract: Kimura proposed a solution for the time-dependent probability of fixation, or loss, of a gene under selection. Example calculations suggest the formulas are prone to numerical inaccuracies. An alternative solution is proposed; the correctness of the solution is confirmed by numerically solving the Kolmogorov backward equation and by simulation.
authors.affiliation: Department of Medical Genetics, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Bruce
authors.initials: B
authors.lastname: Rannala
mesh_terms: D005075:Biological Evolution; D003198:Computer Simulation; D005787:Gene Frequency / Q000235:genetics*; D005796:Genes / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D011336:Probability; D012641:Selection, Genetic; D013997:Time Factors