title: Introduction of the American/Asian genotype of dengue 2 virus into the Yucatan State of Mexico.
abstract: A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asian genotype; this is the first report of this genotype in the Yucatan State. The DEN-2 viruses of the American-Asian genotype have been associated with more severe disease outcomes. Thus, its introduction into the Yucatan State presents a serious problem to public health authorities. During this outbreak, DEN virus infection was confirmed in 18% (282 of 1,560) of the patients who presented with DEN-like symptoms. Of these, 87 (31%) patients met the World Health Organization criteria for dengue hemorrhagic fever, including two patients who died. The majority (77%) of the patients experienced secondary infections in this epidemic.
authors.affiliation: Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Av. Itzáes No. 490 x 59, Centro, Merida, Yucatan, Mexico 97000.
authors.forename: María A
authors.initials: MA
authors.lastname: Loroño-Pino
authors.forename: José A
authors.initials: JA
authors.lastname: Farfán-Ale
authors.forename: Alicia L
authors.initials: AL
authors.lastname: Zapata-Peraza
authors.forename: Elsy P
authors.initials: EP
authors.lastname: Rosado-Paredes
authors.forename: Luis F
authors.initials: LF
authors.lastname: Flores-Flores
authors.forename: Julián E
authors.initials: JE
authors.lastname: García-Rejón
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Díaz
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Blitvich
authors.forename: Manuel
authors.initials: M
authors.lastname: Andrade-Narváez
authors.forename: Eusebio
authors.initials: E
authors.lastname: Jiménez-Ríos
authors.forename: Carol D
authors.initials: CD
authors.lastname: Blair
authors.forename: Ken E
authors.initials: KE
authors.lastname: Olson
authors.forename: William
authors.initials: W
authors.lastname: Black
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Beaty
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D003716:Dengue Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D019595:Severe Dengue / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D012720:Severity of Illness Index
chemical_list: D000914:Antibodies, Viral