[6,8-Dimethyl-2-piperidinomethyl-2,3-dihydrothiazolo[2,3-f]xanthine: a new inductor of the monooxygenase system inhibits experimental intrahepatic cholestasis in rats].
6,8-Dimethyl-2-piperidinomethyl-2,3-dihydrothiazolo[2,3-f]xanthine, a new inductor of the monooxygenase system, inhibited the development of experimental intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats. The drug stimulated the detoxicating function of liver, increased the survivability of rats, restored the level of microsomal protein and cytochrome P-450, decreased the cell-average erythrocyte fragility, and reduced the activity of cholestasis markers and the amount of TBA-active products in hepatocytes.
Nikitina
I L
IL
Alekhin
E K
EK
Khaliullin
F A
FA
D015058:1-Naphthylisothiocyanate / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced / Q000517:prevention & control*; D004912:Erythrocytes / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D014970:Xanthines / Q000494:pharmacology*
C498328:6,8-dimethyl-2-piperidinomethyl-2,3-dihydrothiazolo(2,3-f)xanthine; D010880:Piperidines; D013844:Thiazoles; D014970:Xanthines; D015058:1-Naphthylisothiocyanate; D006899:Mixed Function Oxygenases