title: Acetate-mediated production of orotic acid by ura3 mutants of Candida albicans.
abstract: Candida albicans ura3 mutants were found to produce large amounts of orotic acid when the growth medium was supplemented with sodium acetate. Experiments with 13C-labeled acetate showed that the acetate served as a precursor of orotic acid. This system of acetate-mediated production of orotic acid is similar to other documented microbial producers in yield but unique for its acetate requirement.
authors.affiliation: Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nezu
authors.forename: Osamu
authors.initials: O
authors.lastname: Shimokawa
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D003470:Culture Media; D005656:Fungal Proteins / Q000235:genetics; D009154:Mutation; D009963:Orotic Acid / Q000378:metabolism*
chemical_list: D000085:Acetates; D003470:Culture Media; D005656:Fungal Proteins; D009963:Orotic Acid