title: Motor neuron disease and optic neuropathy after acute exposure to a methanol-containing solvent mixture.
abstract: A 34-years-old floor-layer developed optic neuropathy and motor neuron disease after being accidentally exposed to a solvent mixture containing methanol and other substances. Optic neuropathy is a complication of methanol poisoning, but the onset of a motor neuron disorder resembling amyotrophic lateral sclerosis after the exposure to these substances has not been previously described. The temporal onset of the clinical symptoms, biological plausibility, young age of the patient and absence of neurological disorders in the family history raises suspicion of a possible causative relationship.
authors.affiliation: Neuroscience, University of Turin, Italy. achio@usa.net
authors.forename: Adriano
authors.initials: A
authors.lastname: Chiò
authors.forename: Elena
authors.initials: E
authors.lastname: Herrero Hernandez
authors.forename: Gabriele
authors.initials: G
authors.lastname: Mora
authors.forename: Consuelo
authors.initials: C
authors.lastname: Valentini
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Discalzi
authors.forename: Enrico
authors.initials: E
authors.lastname: Pira
mesh_terms: D000328:Adult; D001931:Brain Mapping; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D000432:Methanol / Q000506:poisoning*; D016472:Motor Neuron Disease / Q000139:chemically induced* / Q000473:pathology; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000473:pathology; D011712:Pyramidal Tracts / Q000473:pathology; D012997:Solvents / Q000506:poisoning
chemical_list: D012997:Solvents; D000432:Methanol