Distribution patterns of trace metals and of lipid peroxidation in plasma and erythrocytes of rat exposed to aluminum.
Significant decreases of the hematocrit, hemoglobin, and plasma iron levels were observed in rats receiving daily intraperitoneal injections of aluminum at a dose of 27 mg Al/kg body wt for 3 wk, as compared to untreated controls. The activity of alkaline phosphatase was also significantly lower in the treated animals as a result of the accumulation of aluminum in the liver (p<0.05). Following aluminum administration, the plasma concentrations of aluminum and copper were also significantly increased, whereas the plasma zinc levels and oxidative stress measured through thiobarbituric acid reaction products showed nonsignificant differences between the two groups (p>0.05). The erythrocyte concentrations of aluminum, copper, zinc, and iron and of superoxide dismutase activity were found to be significantly higher in the study group as compared to controls. The treated animals also showed evidence of higher oxidative stress in comparison to controls. These results suggest that erythrocyte aluminum accumulation could result in abnormal trace element homeostasis and increasing oxidative stress, which might be a mechanism of aluminum-induced anemia.
Guo
Chih-Hung
CH
Department of Food and Nutrition, Hung Kuang University, Taichung 433, Taiwan, Republic of China.
Hsu
Guoo-Shyng W
GS
Lin
Li-Yun
LY
Wang
Yun-Hsin
YH
Lin
Chia-Yeh
CY
Yeh
Maw-Sheng
MS
D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D003300:Copper / Q000097:blood; D004912:Erythrocytes / Q000737:chemistry* / Q000187:drug effects; D007501:Iron / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
D017607:Aluminum Compounds; D002712:Chlorides; D014131:Trace Elements; D000077410:Aluminum Chloride; D003300:Copper; D000535:Aluminum; D007501:Iron; D013482:Superoxide Dismutase; D015032:Zinc