The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate.
Chloral hydrate is a sedative commonly used in pediatric medicine. It was evaluated for genotoxicity in cultured peripheral blood lymphocytes of infants who were given chloral hydrate for sedation. Sister chromatid exchange and micronucleus frequencies were determined before and after chloral hydrate administration. After treatment, the frequencies of sister chromatid exchange and micronuclei were significantly increased, suggesting that chloral hydrate has moderate genotoxic potential in infants.
Ikbal
Mevlit
M
Department of Medical Genetics, Medical Faculty, Ataturk University, 25240 Erzurum, Turkey. mevlitikbal@hotmail.com
Tastekin
Ayhan
A
Dogan
Hasan
H
Pirim
Ibrahim
I
Ors
Rahmi
R
D001973:Bromodeoxyuridine; D002697:Chloral Hydrate / Q000009:adverse effects*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D012854:Sister Chromatid Exchange / Q000187:drug effects
D002697:Chloral Hydrate; D001973:Bromodeoxyuridine