title: [Effects of low-dose accelerated charged particles of varying LET on cytogenetic changes in comeal epithelium cells in mice].
abstract: Effects of low-dose heavy charged particles (HCP) of varying LET on quantitative and qualitative changes in chromosomes of the comeal epithelium cells were studied in mice. Cytogenetic damages in the comeal epithelium cells were analyzed after irradiation by ions of helium and carbon with an energy of 300 MeV/nucleon (LET = 1.36 and 12.6 keV/microm), and 137Cs gamma-rays with the doses from 5 to 200 Gy. Accelerated nuclei were shown to be more effective. On the basis of aberrant mitosis rate, RBE values for helium and carbon ions in 24, 72 and 120 hrs. after irradiation were 6.0; 3.6 and 2.2 for helium ions and 7.0; 3.8 and 2.4 for carbon ions, respectively. The dose region of 20-30 Gy turned to be dose-independent. It was established that the period of chromosomal aberration sustenance in cells is also LET-dependent.
authors.forename: S V
authors.initials: SV
authors.lastname: Vorozhtsova
authors.forename: B S
authors.initials: BS
authors.lastname: Fedorenko
authors.forename: V V
authors.initials: VV
authors.lastname: Tsetlin
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000528:radiation effects*; D019573:Epithelium, Corneal / Q000473:pathology* / Q000528:radiation effects*; D006371:Helium / Q000008:administration & dosage; D018499:Linear Energy Transfer; D051379:Mice; D008810:Mice, Inbred C57BL; D010315:Particle Accelerators; D011829:Radiation Dosage; D011839:Radiation, Ionizing
chemical_list: D006371:Helium