title: The jing and ras1 pathways are functionally related during CNS midline and tracheal development.
abstract: The Drosophila jing gene encodes a zinc finger protein required for the differentiation and survival of embryonic CNS midline and tracheal cells. We show that there is a functional relationship between jing and the Egfr pathway in the developing CNS midline and trachea. jing function is required for Egfr pathway gene expression and MAPK activity in both the CNS midline and trachea. jing over-expression effects phenocopy those of the Egfr pathway and require Egfr pathway function. Activation of the Egfr pathway in loss-of-function jing mutants partially rescues midline cell loss. Egfr pathway genes and jing show dominant genetic interactions in the trachea and CNS midline. Together, these results show that jing regulates signal transduction in developing midline and tracheal cells.
authors.affiliation: Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ont., Canada. msonnenf@uottawa.ca
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Sonnenfeld
authors.forename: Nasrin
authors.initials: N
authors.lastname: Barazesh
authors.forename: Yalda
authors.initials: Y
authors.lastname: Sedaghat
authors.forename: Cathy
authors.initials: C
authors.lastname: Fan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004330:Drosophila / Q000196:embryology* / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009420:Nervous System / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D010641:Phenotype; D012137:Respiratory System / Q000196:embryology / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; C421383:JING protein, Drosophila; D009687:Nuclear Proteins; D014157:Transcription Factors; D066246:ErbB Receptors; D020928:Mitogen-Activated Protein Kinases; C417283:Ras85D protein, Drosophila; D018631:ras Proteins