[Effect of pentoxifylline on Doppler blood flow parameters in the central retinal artery and the short posterior ciliary arteries in adolescents with progressive myopia].
OBJECTIVE
To evaluate the effect of pentoxifylline on blood flow in the central retinal artery and the short posterior ciliary arteries in patients with progressive myopia.


METHODS
48 eyes of 24 healthy patients aged between 12 and 18 years (mean 15.1 years) with myopia from -5.0 to -12.75 Dsph (mean -7.56 Dsph), were examined using color Doppler ultrasonography. The examination was performed before and after 10 days of intravenous administration of 200 mg of pentoxifylline. The peak-systolic, end-diastolic flow velocities, pulsatility, resistance and systolic/diastolic ratios were measured.


RESULTS
The use of pentoxifylline significantly increased PSV and EDV in the central retinal artery and in the short posterior ciliary arteries (p=0.0001) in patients with progressive myopia and in the same time decreased PI, RI and S/D (p=0.0001). There was no correlation between Doppler blood flow parameters and dioptres or axial length.


CONCLUSIONS
pentoxifylline increases retinal and choroidal blood flow in young patients with progressive myopia.
Urban
Beata
B
Z Kliniki Okulistyki Dzieciecej Akademii Medycznej w Białymstoku.
Ustymowicz
Andrzej
A
Bakunowicz-Lazarczyk
Alina
A
Kretowska
Małgorzata
M
D000293:Adolescent; D019842:Ciliary Arteries / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D047728:Myopia, Degenerative / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D010431:Pentoxifylline / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012161:Retinal Artery / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D018608:Ultrasonography, Doppler; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D010431:Pentoxifylline