Local endovascular treatment of aortic aneurysms. From operating theater to lab bench.
Current treatment of aortic abdominal aneurysms by conventional surgery or endoprosthesis is flawed by high post-operative mortality and unpredictable durability of haemodynamic exclusion, respectively. We have developed endovascular approaches with cell and gene transfer, aimed at controlling further diameter expansion in an animal model of already-developed aneurysms in rats. Preliminary results suggest that both cell and gene endovascular therapy can be used to control expansion of aneurysms generated by inflammation and proteolytic destruction of the aortic wall.
Allaire
E
E
CNRS UMR 7054, IFR de médecine, Université Paris XII, Assistance publique-Hôpitaux de Paris, Centre de recherches chirurgicales, Créteil. allaire@club-internet.fr
Dai
J
J
Schneider
F
F
Jousset
Y
Y
Losy
F
F
Van Laere
O
O
Pagès
C
C
Smedile
G
G
Guinault
A M
AM
Ginat
M
M
Desgranges
P
P
Loisance
D
D
Becquemin
J P
JP
D000818:Animals; D001014:Aortic Aneurysm / Q000473:pathology / Q000628:therapy*; D017690:Cell Transplantation; D004195:Disease Models, Animal; D015316:Genetic Therapy / Q000379:methods; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D019899:Paracrine Communication / Q000235:genetics; D051381:Rats; D016212:Transforming Growth Factor beta / Q000235:genetics
D016212:Transforming Growth Factor beta