title: Fumonisin B1 causes multiple lesions in common carp (Cyprinus carpio).
abstract: Year-1 carp were fed ratios containing 100mg/kg and 10 mg/kg of added fumonisin B1 for 42 days. The experimental and control fish were examined clinically during the experiment and at the end all fish were necropsied and histological changes recorded. Blood vessels, liver, exocrine and endocrine pancreas, excretory and haematopoietic kidney, heart and brain were sensitive both to 100 and 10mg/kg of FB1 in the diet and the rodlet cell (RC) frequency was considerably increased in and around damaged tissues. Many damaged blood vessels contained stacks of RCs above the endothelium. Other changes subsequent to fumonisin exposure that have not been previously reported include scattered lesions in the exocrine and endocrine pancreas, and interrenal tissue, probably due to ischemia and/or increased endothelial permeability. Presented findings indicate the need for more intensive studies of fumonisin-induced toxicity in cultured fish.
authors.affiliation: Department for Biology and Pathology of Fishes and Bees, Veterinary Faculty, University of Zagreb, Croatia.
authors.forename: Z
authors.initials: Z
authors.lastname: Petrinec
authors.forename: S
authors.initials: S
authors.lastname: Pepeljnjak
authors.forename: S
authors.initials: S
authors.lastname: Kovacic
authors.forename: A
authors.initials: A
authors.lastname: Krznaric
mesh_terms: D000818:Animals; D002274:Carcinogens, Environmental / Q000378:metabolism / Q000633:toxicity*; D002347:Carps; D004305:Dose-Response Relationship, Drug; D005393:Fish Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology*; D037341:Fumonisins / Q000378:metabolism / Q000633:toxicity*; D011897:Random Allocation; D018675:Toxicity Tests / Q000662:veterinary
chemical_list: D002274:Carcinogens, Environmental; D037341:Fumonisins; C056933:fumonisin B1