title: Flowability measurements of pharmaceutical powder mixtures with poor flow using five different techniques.
abstract: Four different tablet formulations for direct compression with poor flow properties were tested regarding flowability using five different techniques: Hausner ratio, avalanching behavior, powder rheometer, uniaxial tester, and Jenike tester. In addition, the behavior of three of the formulations during emptying of the mixer and tableting was observed and compared to the results of the flowability measurements. The rank order correlation of the formulations was generally the same with all techniques. The flow properties measured by the different techniques reflected the behavior during processing of the powder mixtures.
authors.affiliation: Pharmacia Consumer Healthcare, Pharmaceutical R&D, Helsingborg, Sweden. nils-olof.lindberg@galenica.se
authors.forename: Nils-Olof
authors.initials: NO
authors.lastname: Lindberg
authors.forename: Magnus
authors.initials: M
authors.lastname: Pålsson
authors.forename: Ann-Christin
authors.initials: AC
authors.lastname: Pihl
authors.forename: Reg
authors.initials: R
authors.lastname: Freeman
authors.forename: Tim
authors.initials: T
authors.lastname: Freeman
authors.forename: Harald
authors.initials: H
authors.lastname: Zetzener
authors.forename: Gisle
authors.initials: G
authors.lastname: Enstad
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D011208:Powders; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D011208:Powders; D013607:Tablets