Peptide YY release after colectomy in slow transit constipation.
BACKGROUND
The gut hormone peptide YY is abundant in the colonic mucosa. Circulating PYY inhibits gastrointestinal motility and decreases food intake. The aim was to determine whether colectomy decreases PYY release in patients with slow transit constipation.


METHODS
Plasma PYY concentrations were measured in 10 patients with slow transit constipation before and 3-24 months after total abdominal colectomy with ileorectal anastomosis, and in 8 healthy controls. A liquid meal was infused intraduodenally to stimulate PYY release.


RESULTS
Postprandial PYY significantly (P < 0.05) increased from a basal value of 15.6 +/- 1.8 pM to a peak of 71.2 +/- 11.6 pM after colectomy. Basal and postprandial plasma PYY concentrations were not significantly different from the results before surgery. Fasting, but not postprandial, plasma peptide YY after colectomy was significantly higher than that in healthy volunteers, 10.9 +/- 0.9 pM.


CONCLUSIONS
Despite removal of a major source of PYY-secreting cells, colectomy with ileorectal anastomosis does not induce major impairment of PYY release in slow transit constipation.
Hopman
W P M
WP
Dept. of Gastroenterology and Hepatology, University Medical Center Nijmegen, Nijmegen, The Netherlands. W.Hopman@mdl.umcn.nl
Mollen
R M H G
RM
Kuijpers
J H C
JH
Jansen
J B M J
JB
D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D003082:Colectomy; D003248:Constipation / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D007082:Ileum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019894:Peptide YY / Q000097:blood* / Q000378:metabolism; D012007:Rectum / Q000601:surgery
D019894:Peptide YY