title: Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation.
abstract: During haematogenous metastasis, cancer cells migrate to the vasculature and interact with platelets resulting in tumour cell-induced platelet aggregation (TCIPA). We review: 1. The biological and clinical significance of TCIPA; 2. Molecular mechanisms involved in platelet aggregation by cancer cells; 3. Strategies for pharmacological regulation of these interactions. We conclude that pharmacological regulation of platelet-cancer cell interactions may reduce the impact of TCIPA on cancer biology.
authors.affiliation: Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas-Houston, Houston, TX, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Jurasz
authors.forename: David
authors.initials: D
authors.lastname: Alonso-Escolano
authors.forename: Marek W
authors.initials: MW
authors.lastname: Radomski
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010975:Platelet Aggregation Inhibitors