title: Diagnostic use of T2-weighted inversion-recovery magnetic resonance imaging in acute coronary syndromes compared with 99mTc-Pyrophosphate, 123I-BMIPP and 201TlCl single photon emission computed tomography.
abstract: BACKGROUND
  The incidence of missed diagnoses of acute cardiac ischemia in the emergency department could be reduced by a new imaging modality. In the present study, the clinical significance of (99m)Tc-pyrophosphate (PYP), (123)I-beta-methyl-p-iodephenyl-pentadecanoic acid (BMIPP), (201)TlCl scintigraphy (imaging) and T2-weighted inversion-recovery magnetic resonance imaging (MRI) for the detection of culprit lesion in patients with acute coronary syndromes (ACS) was compared.
  
  
  RESULTS
  The study group comprised 18 patients with ACS: 12 patients with acute myocardial infarction (AMI) (11 males; mean age, 63+/-11 years) and 6 patients with unstable angina (UA) (3 males, mean age, 67+/-5 years). Of the 12 patients with AMI, 10 underwent (201)TlCl and PYP single photon emission computed tomography (SPECT) studies as a dual-energy acquisition ((201)TlCl/PYP) and 8 underwent (201)TlCl SPECT within 1 week of the BMIPP study. All 18 patients underwent BMIPP SPECT and MRI. The MRI pulse sequence was black blood turbo short-inversion-time inversion recovery (STIR) (breath-hold T2-weighted studies). The T2-weighted inversion-recovery MRI showed higher sensitivity and negative predictive value than PYP and (201)TlCl, and higher specificity and positive predictive value than BMIPP and (201)TlCl. The area under the receiver-operating characteristic curve for PYP, BMIPP, (201)TlCl and MRI was 0.787, 0.725, 0.731 and 0.878, respectively. The difference between the areas of MRI and BMIPP was significant (p<0.05).
  
  
  CONCLUSIONS
  Accurate detection of culprit lesion is improved by using MRI rather than BMIPP, particularly for patients with ACS.
authors.affiliation: Department of Radiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. nobut@fukuhp.yokohama-cu.ac.jp
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Takahashi
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
authors.forename: Tadasi
authors.initials: T
authors.lastname: Oka
authors.forename: Akiko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Tuyosi
authors.initials: T
authors.lastname: Kawano
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Uchino
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Mochida
authors.forename: Tosiaki
authors.initials: T
authors.lastname: Ebina
authors.forename: Katumi
authors.initials: K
authors.lastname: Matumoto
authors.forename: Youhei
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Satosi
authors.initials: S
authors.lastname: Umemura
mesh_terms: D000208:Acute Disease; D000368:Aged; D003327:Coronary Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005227:Fatty Acids; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D013577:Syndrome; D016698:Technetium Tc 99m Pyrophosphate; D013793:Thallium; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013794:Thallium Radioisotopes; C049338:iodofiltic acid; C027549:thallium chloride; D016698:Technetium Tc 99m Pyrophosphate; D013793:Thallium