title: Long-lasting effects of social stress on peritoneal inflammation in some strains of mice.
abstract: Adult male mice were kept for one week either one or four animals per cage. Some were maintained under the same social conditions for an additional 9 days (controls); their counterparts were either grouped (4 per cage) or isolated (1 per cage). Changes in housing conditions caused a significant increase of plasma corticosterone measured 30 minutes after separation or grouping of SWISS, C57C3H, and BALB/c but not of C57BL/6 mice. Peritoneal inflammation was induced by i.p. zymosan injection on day 9 after changes in housing conditions when corticosterone was again at its initial level in each group. Peritonitis-connected pain symptoms, exudatory PMN numbers, and cytokine (IL-1beta and MPC-1) and corticosterone levels were compared between animals living in stable social conditions with those shifted 9 days earlier from separation to the group or vice versa. These factors were unaffected by social stress in C57BL/6 mice and in SWISS animals transferred from the group to isolation. In all other instances at least two parameters were significantly different in the post-stressed and control animals, being either enhanced or inhibited. In conclusion, social stress had long-term consequences on the course of inflammation in three out of four investigated strains of mice.
authors.affiliation: Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, 30-060 Kraków, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Scislowska-Czarnecka
authors.forename: Magdalena
authors.initials: M
authors.lastname: Chadzinska
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pierzchala-Koziec
authors.forename: Barbara
authors.initials: B
authors.lastname: Plytycz
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003441:Crowding / Q000503:physiopathology*; D016207:Cytokines / Q000097:blood; D006799:Housing, Animal; D008297:Male; D051379:Mice / Q000502:physiology*; D008815:Mice, Inbred Strains; D010538:Peritonitis / Q000503:physiopathology*; D011863:Radioimmunoassay; D012931:Social Environment; D013045:Species Specificity; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D016207:Cytokines; D003345:Corticosterone