title: Mathematical estimation of the potential effect of vascular remodelling/dilatation on B-mode ultrasound intima-medial thickness.
abstract: BACKGROUND
  Arterial diameter changes are known to impact wall thickness, but the clinical relevance of the changes is unclear.
  
  
  OBJECTIVE
  To use known mathematical relationships to estimate anticipated changes in arterial wall thicknesses occurring with enlargement of atherosclerotic regions.
  
  
  METHODS
  Mathematical relationships between a cylinder's diameter and its wall thickness were used to calculate the theoretical effect of diameter enlargement on the thickness of an atherosclerotic wall.
  
  
  METHODS
  Equating the wall areas of two cylinders, one of smaller diameter than the other, allowed estimation of the degree of thickening that would be needed to maintain intima-medial thickness (IMT) after arterial remodelling. The difference in cylinder diameters was based on arterial diameter enlargement reported with atherosclerosis progression. Thus, the calculated wall changes estimate arterial changes which could go undetected if only IMT is measured by ultrasound.
  
  
  RESULTS
  The expected IMT change for diameter enlargement is not a linear function of the diameter change, but varies depending upon initial size (diameter and IMT). Thus a 0.6 mm arterial diameter enlargement would be expected to cause a 0.039-0.235 mm change in IMT, depending on artery size. The estimated IMT change is similar to that associated with major atherosclerotic risk factors.
  
  
  CONCLUSIONS
  The level of vascular remodelling reported with atherosclerosis could have a measurable impact on IMT, suggesting that indicators incorporating both diameter and IMT may be better disease indicators than IMT alone. Arterial diameters, as well as IMT, should be obtained in ultrasound studies of atherosclerosis.
authors.affiliation: Department of Epidemiology, University of Arkansas for Medical Sciences College of Public Health, 4301 W. Markham, Slot 820, Little Rock, Arkansas 72205, USA. eigenbrodtmarshal@uams.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Eigenbrodt
authors.forename: Z
authors.initials: Z
authors.lastname: Bursac
authors.forename: E P
authors.initials: EP
authors.lastname: Eigenbrodt
authors.forename: D J
authors.initials: DJ
authors.lastname: Couper
authors.forename: R E
authors.initials: RE
authors.lastname: Tracy
authors.forename: J L
authors.initials: JL
authors.lastname: Mehta
mesh_terms: D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography; D014664:Vasodilation