Microbial metabolism. Part 5. Dihydrokawain.
Preparative scale fermentation of (6S)-dihydrokawain (1) with Rhizopus arrhizus (ATCC 11145) gave 3'-hydroxydihydrokawain (2) and (8S)-hydroxydihydrokawain (3). Structure elucidation of the metabolites was based on spectroscopic data. The C-8 absolute configuration of (3) was assessed via its Mosher's esters.
Herath
Wimal
W
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA.
Ferreira
Daneel
D
Mikell
Julie Rakel
JR
Khan
Ikhlas Ahmad
IA
D020901:Kava / Q000378:metabolism* / Q000382:microbiology*; D035261:Plant Components, Aerial / Q000382:microbiology; D010936:Plant Extracts / Q000302:isolation & purification / Q000378:metabolism; D011753:Pyrones / Q000302:isolation & purification / Q000378:metabolism*; D012233:Rhizopus / Q000302:isolation & purification / Q000378:metabolism*
D010936:Plant Extracts; D011753:Pyrones; C414106:dihydrokawain-5-ol