Novel rhodium-catalyzed reaction of thiazolidine derivatives with carbodiimides.
A new, simple, and regioselective synthesis of thiazolidinimine derivatives based on the rhodium-catalyzed reaction of readily available thiazolidines with carbodiimides is described. This methodology provides direct access to a large variety of thiazolidinimine derivatives, possibly via a novel regiospecific insertion of carbodiimides into one of two ring carbon-nitrogen bonds, as well as a metal-catalyzed imine elimination process.
Zhou
Hai-Bing
HB
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, K1N 6N5, Canada.
Dong
Chune
C
Alper
Howard
H
D002234:Carbodiimides / Q000737:chemistry*; D002384:Catalysis; D008956:Models, Chemical; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D013844:Thiazoles / Q000737:chemistry*
D002234:Carbodiimides; D013844:Thiazoles; D012238:Rhodium