Hedgehog signaling: measuring ligand concentrations with receptor ratios.
How the binding of Hedgehog to its receptor, Patched, initiates signaling is poorly understood. A recent study suggests a mechanism by which the ratio of unliganded to liganded Patched determines the cellular response.
Briscoe
James
J
Developmental Neurobiology, National Institute for Medical Research The Ridgeway, Mill Hill, London, NW7 1AA, UK.
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation; D053823:Hedgehog Proteins; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D000072086:Smoothened Receptor
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; C077245:hh protein, Drosophila; D008024:Ligands; D008565:Membrane Proteins; C070844:ptc protein, Drosophila; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C100664:smo protein, Drosophila; D000072086:Smoothened Receptor