[Correlation of the expression of MDR genes and MDR genes-coded product with prognosis in laryngopharyngeal malignant melanoma].
OBJECTIVE
To study the correlation of expression implication of MDR genes (GST-pi and Topo II) and MDR gene-coded product (Pgp) with prognosis in laryngopharyngeal malignant melanoma.


METHODS
Using immunohistochemical S-P method,expression of GST-pi, Topo II and Pgp was detected in 28 cases of laryngopharyngeal malignant melanoma. The relationship between GST-pi, Topo II, Pgp and clinicopathological features, prognosis of the tumors were also analyzed.


RESULTS
The positive rates of Pgp, GST-pi and Topo II were 35.7%, 57.1% and 46.4% respectively in 28 cases of laryngopharyngeal malignant melanoma, without significant difference (P > 0.05). The positive rates of Pgp, GST-pi and Topo II were not correlated with sex,age, size of tumor and Clark's grade, Breslow's grade (P > 0.05), but AJC grade and prognosis (P < 0.05).


CONCLUSIONS
Expression of Pgp,GST-pi and Topo II may be the chief mechanism of multi-drug resistance. Detection of multi-drug resistance genes is of necessity and feasibility when predicting the effect of chemotherapy.
Chen
Xi
X
Department of Otolaryngology, Affiliated First Hospital, Fujian Medical University, Fuzhou 350005.
Ji
Tianhai
T
Yao
Liqing
L
Yang
Jingsong
J
Deng
Jun
J
Zhang
Zaigen
Z
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D004250:DNA Topoisomerases, Type II / Q000096:biosynthesis*; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D019450:Genes, MDR / Q000235:genetics*; D051549:Glutathione S-Transferase pi / Q000096:biosynthesis*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D051549:Glutathione S-Transferase pi; D004250:DNA Topoisomerases, Type II