title: Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone.
abstract: The inflammatory response to ozone in atopic asthma suggests that soluble mediators of inflammation are released in response to oxidant stress. Antioxidants may alleviate additional oxidative stress associated with photochemical oxidant pollution. This study investigates the impact of antioxidant supplementation on the nasal inflammatory response to ozone exposure in atopic asthmatic children. We conducted a randomized trial using a double-blinded design. Children with asthma (n = 117), residents of Mexico City, were given randomly a daily supplement of vitamins (50 mg/day of vitamin E and 250 mg/day of vitamin C) or placebo. Nasal lavages were performed three times during the 4-month follow-up and analysed for content of interleukin-6 (IL-6), IL-8, uric acid and glutathione (GSx). IL-6 levels in the nasal lavage were increased significantly in the placebo group after ozone exposure while no increase was observed in the supplement group. The difference in response to ozone exposure between the two groups was significant (P = 0.02). Results were similar for IL-8, but with no significant difference between the groups (P = 0.12). GSx decreased significantly in both groups. Uric acid decreased slightly in the placebo group. Our data suggest that vitamin C and E supplementation above the minimum dietary requirement in asthmatic children with a low intake of vitamin E might provide some protection against the nasal acute inflammatory response to ozone.
authors.affiliation: Hospital Infantil de México, Federico Gómez, México.
authors.forename: J J
authors.initials: JJ
authors.lastname: Sienra-Monge
authors.forename: M
authors.initials: M
authors.lastname: Ramirez-Aguilar
authors.forename: H
authors.initials: H
authors.lastname: Moreno-Macias
authors.forename: N I
authors.initials: NI
authors.lastname: Reyes-Ruiz
authors.forename: B E
authors.initials: BE
authors.lastname: Del Río-Navarro
authors.forename: M X
authors.initials: MX
authors.lastname: Ruiz-Navarro
authors.forename: G
authors.initials: G
authors.lastname: Hatch
authors.forename: K
authors.initials: K
authors.lastname: Crissman
authors.forename: R
authors.initials: R
authors.lastname: Slade
authors.forename: R B
authors.initials: RB
authors.lastname: Devlin
authors.forename: I
authors.initials: I
authors.lastname: Romieu
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001249:Asthma / Q000178:diet therapy / Q000276:immunology*; D002648:Child; D019587:Dietary Supplements; D004311:Double-Blind Method; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005978:Glutathione / Q000032:analysis; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D008297:Male; D009296:Nasal Cavity / Q000276:immunology; D018384:Oxidative Stress / Q000276:immunology; D010126:Ozone / Q000276:immunology* / Q000633:toxicity; D014527:Uric Acid / Q000032:analysis; D014810:Vitamin E / Q000008:administration & dosage*; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000393:Air Pollutants; D000975:Antioxidants; D015850:Interleukin-6; D016209:Interleukin-8; D014810:Vitamin E; D014527:Uric Acid; D010126:Ozone; D005978:Glutathione; D024502:alpha-Tocopherol; D001205:Ascorbic Acid