Assignment of canine MSS1 microsatellite markers to chromosomes by linkage data.
Recent advances in mapping the canine genome have led to an increase in the number of linkage studies aimed at dissecting the genetic causes of many hereditary diseases that affect the domestic dog. The first step in developing molecular tools for a whole genome scan was the characterization of a set of microsatellite markers, termed minimal screening set 1 (MSS1), that provided an estimated coverage of 10 cM. A limiting factor in use of the MSS1 is not all of the 172 MSS1 markers have been localized to specific chromosomes. Seventy-five of the markers were positioned on a total of 15 chromosomes with the original publication of the MSS1. The localization based on linkage data of 14 additional MSS1 markers to chromosomes using CRIMAP v. 2.4 to build a linkage map of 113 MSS1 markers that were polymorphic in a kindred of Dalmatians is reported here.
Cargill
E J
EJ
Department of Pathobiology and Program in Genetics, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467, USA.
Schnabel
R D
RD
Murphy
K E
KE
D000818:Animals; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian / Q000235:genetics*; D004285:Dogs / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics*; D021101:Radiation Hybrid Mapping