title: Cobalt-mediated cyclotrimerisation of bis-alkynes and cyanamides.
abstract: CpCo(CO)2-mediated cyclotrimerisation of bis-alkynes and cyanamides provides multisubstituted 2-aminopyridines, including macrocyclic products, such as 22 (50% yield).
authors.affiliation: Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Spring House, PA 19477-0776, USA.
authors.forename: Llorente V R
authors.initials: LV
authors.lastname: Boñaga
authors.forename: Han-Cheng
authors.initials: HC
authors.lastname: Zhang
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Maryanoff
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D003484:Cyanamide / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000480:Alkynes; D009942:Organometallic Compounds; D003035:Cobalt; D003484:Cyanamide