title: Dai-kenchu-to raises levels of calcitonin gene-related peptide and substance P in human plasma.
abstract: Sensory afferent neurons in the gastrointestinal mucosa regulate neuropeptides [calcitonin gene-related peptide (CGRP), substance P, etc.], which play various physiologic roles and are gastroprotective. To determine whether the pharmacologic effects of Dai-kenchu-to (DKCT) on the gastrointestine are due to changes in gastrointestinal mucosa regulatory peptide levels, we examined the effects of the DKCT on the levels of CGRP-like immunoreactive substances (IS) and substance P-IS in plasma taken from five healthy subjects. A single oral administration of DKCT 7.5 g caused significant increases in plasma CGRP-IS at 40 min, and in substance P-IS levels at 20 and 60 min, compared with a placebo group. The present study may indicate that the pharmacologic action of DKCT is closely related to changes in CGRP- and substance P-IS levels.
authors.affiliation: Department of Clinical Pharmacy, Oita University Hospital, Oita, Japan. SYUHKI@med.oita-u.ac.jp
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Sato
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Katagiri
authors.forename: Shin
authors.initials: S
authors.lastname: Inoue
authors.forename: Hiroki
authors.initials: H
authors.lastname: Itoh
authors.forename: Masaharu
authors.initials: M
authors.lastname: Takeyama
mesh_terms: D000284:Administration, Oral; D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D008297:Male; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology*; D013373:Substance P / Q000097:blood*; D013997:Time Factors; D032106:Zanthoxylum; D030521:Zingiberaceae
chemical_list: D005765:Gastrointestinal Agents; D010936:Plant Extracts; C121414:dai-kenchu-to; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide