title: Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese.
abstract: Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Nawata
authors.affiliation: Department of Pathology, Research Institute, International Medical Center, Tokyo, Japan.
authors.forename: Senji
authors.initials: S
authors.lastname: Shirasawa
authors.affiliation: Department of Medical Informatics, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakashima
authors.affiliation: Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Araki
authors.affiliation: Tenposan Clinic, Kagoshima, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Hashiguchi
authors.affiliation: Sasebo Central Hospital, Nagasaki, Japan.
authors.forename: Seibei
authors.initials: S
authors.lastname: Miyake
authors.affiliation: Yukuhashi Central Hospital, Fukuoka, Japan.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Yamauchi
authors.affiliation: Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hamaguchi
authors.affiliation: Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
authors.affiliation: Yatsushiro General Hospital, Kumamoto, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Takeda
authors.affiliation: Public Tamana Central Hospital, Kumamoto, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Fukushima
authors.affiliation: Omuta Tenryo Hospital, Fukuoka, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sasahara
authors.affiliation: Oita Prefectural Hospital, Oita, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamaguchi
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sonoda
authors.affiliation: Sonoda Clicin, Kagoshima, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sonoda
authors.affiliation: Kitakyushu Municipal Medical Center, Fukuoka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: First Department of Internal Medicine, School of Medicine, University of Occupational & Environmental Health, Fukuoka, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka
authors.affiliation: Sugimoto Clinic, Fukuoka, Japan.
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Sugimoto
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tsubouchi
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Toyoshi
authors.initials: T
authors.lastname: Inoguchi
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yanase
authors.affiliation: National Health Insurance Takachiho Town Hospital, Miyazaki, Japan.
authors.forename: Nakayasu
authors.initials: N
authors.lastname: Wake
authors.affiliation: Narazaki Clinic, Fukuoka, Japan.
authors.forename: Kenziro
authors.initials: K
authors.lastname: Narazaki
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Eto
authors.affiliation: Diabetology and Endocrinology Division of Internal Medicine, Fukuoka Medical Association Hospital, Fukuoka, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Umeda
authors.affiliation: Department of Cardiovascular, Respiratory & Metabolic Medicine Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nakazaki
authors.affiliation: Department of Laboratory Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Ono
authors.affiliation: First Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Asano
authors.affiliation: Furugou Clinic, Oita, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Shin-Koga Hospital, Fukuoka, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Akazawa
authors.affiliation: Kamiamakusa General Hospital, Kumamoto, Japan.
authors.forename: Iwaho
authors.initials: I
authors.lastname: Hazegawa
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takasu
authors.affiliation: National Health Insurance Matsubase Town Hospital, Kumamoto, Japan.
authors.forename: Moritsugu
authors.initials: M
authors.lastname: Shinohara
authors.affiliation: Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishikawa
authors.affiliation: Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Seiho
authors.initials: S
authors.lastname: Nagafuchi
authors.affiliation: Shin-Kokura Hospital, Fukuoka, Japan.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Okeda
authors.affiliation: First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Iwase
authors.affiliation: Department of Pathology, Research Institute, International Medical Center, Tokyo, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Ishikawa
authors.affiliation: Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Aoki
authors.affiliation: Research Institute, International Medical Center of Japan, Tokyo, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Keicho
authors.affiliation: Research Institute, International Medical Center of Japan, Tokyo, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kato
authors.affiliation: Research Institute, International Medical Center of Japan, Tokyo, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yasuda
authors.affiliation: Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. sasazuki@nciryo.hosp.go.jp.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Sasazuki
mesh_terms: D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D007564:Japan; D008126:Lod Score