title: Isolated noncompaction involving the left ventricular apex in adults.
abstract: We present a series of 9 adults in 2 families with isolated noncompaction of the ventricular myocardium involving the left ventricular apex. Three of these patients had been previously misdiagnosed as having dilated cardiomyopathy, apical hypertrophic cardiomyopathy, or apical mural thrombus. Phenotypic variation was observed with gradation of severity of noncompaction and left ventricular systolic dysfunction between first-degree relatives.
authors.affiliation: Department of Cardiology, Concord Hospital, University of Sydney, Concord, New South Wales, Australia.
authors.forename: Tommy
authors.initials: T
authors.lastname: Chung
authors.forename: John
authors.initials: J
authors.lastname: Yiannikas
authors.forename: Lincoln C L
authors.initials: LC
authors.lastname: Lee
authors.forename: George T
authors.initials: GT
authors.lastname: Lau
authors.forename: Leonard
authors.initials: L
authors.lastname: Kritharides
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D003937:Diagnosis, Differential; D018618:Echocardiography, Doppler, Color; D015716:Electrocardiography, Ambulatory; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D010375:Pedigree; D013318:Stroke Volume / Q000235:genetics; D014057:Tomography, X-Ray Computed