title: [An experimental study on anti-aging action of Cordyceps extract].
abstract: OBJECTIVE
  To investigate anti-aging effect and mechanism of Cordyceps extract(CSE) on aged mice induced by D-galactose.
  
  
  METHODS
  The aged mice were induced by D-galactose. Meanwhile, they were treated with three doses of CSE. Then the ability of learning and memory, the activity of antioxidase in the different tissue, the contents of MDA of brain and liver were measured after 6 weeks.
  
  
  RESULTS
  CSE could significantly increase the ability of learning and memory, improve the activity of SOD of red blood cells, brain and liver, the activity of Na(+) -K(+) -ATPE of brain, the activity of CAT and GSH-Px of blood, and remarkably decrease the activity of MAO of brain and the contents of MDA of brain and liver.
  
  
  CONCLUSIONS
  CSE has good anti-aging effects on the aged mice, which is probably due to effects of improving antioxidation and removing free radicals.
authors.affiliation: School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Wang
authors.forename: Jia
authors.initials: J
authors.lastname: Ye
authors.forename: Chang-Ling
authors.initials: CL
authors.lastname: Li
authors.forename: Shao-Qing
authors.initials: SQ
authors.lastname: Cai
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishizaki
authors.forename: Masanori
authors.initials: M
authors.lastname: Katada
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D032661:Cordyceps / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005690:Galactose; D005979:Glutathione Peroxidase / Q000378:metabolism; D007915:Lepidoptera / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D008995:Monoamine Oxidase / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase; D000254:Sodium-Potassium-Exchanging ATPase; D005690:Galactose