[Expression of transforming growth factor-betal (TGF-beta1) and its role in human laryngeal and hypopharyngeal carcinoma].
OBJECTIVE
To detect the mRNA expression of transforming growth factor-betal (TGF-beta1) in laryngeal and hypopharyngeal carcinoma, and to explore the pathogenesis of the two types neoplasms.


METHODS
We examined the expression of TGF-beta1 mRNA in the tissue of human laryngeal and hypopharyngeal carcinoma from patients. The TGF-beta1 mRNA expression was determined by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR).


RESULTS
The TGF-beta1 mRNA expression was significantly stronger in 17 cases of 20 laryngeal and hypopharyngeal carcinoma.


CONCLUSIONS
The result suggested that the expression level of TGF-beta1 in laryngeal and hypopharyngeal carcinoma may inhibit the human immunity and enhance the growth and metastasis of the laryngeal and hypopharyngeal carcinoma.
Chen
Xuemei
X
Department of Otolaryngology, the Second Affiliated Hospital of Shandong University, Jinan 250033.
Zhang
Daliang
D
Zhao
Jiandong
J
Wang
Rui
R
Feng
Jinbo
J
Xu
Xiaoqun
X
Wei
Haiming
H
D000368:Aged; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D053773:Transforming Growth Factor beta1
D012333:RNA, Messenger; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1