[Determination of constant for the inclusion complex of Yinqiao volatile oil with beta-cyclodextrin].
OBJECTIVE
To determine the constant for the inclusion complex of Yinqiao volatile oil with beta-cyclodextrin.


METHODS
The stability constant for the inclusion complex of Yinqiao the volatile oil with beta-cyclodextrin was detemined under multiwavelength by ultraviolet spectroscopy, and spectroscopy feature for inclusion complex was studied. The phase solubility-curve showed the inclusion proportion. The inclusion complex of Yinqiao the volatile oil with beta-cyclodextrin was prepared by saturated aqueous solution. The DTA spectroscopy of inclusion complex was different from not only oil with beta-cyclodextrin but also the mixture of them.


RESULTS
The inclusion complex of Yinqiao the volatile oil with beta-cyclodextrin was formed. The experimental data of inclusion complex fitted well to the molar ratio of 1:1. There was good liner feature under multiwavelength of ultraviolet spectroscopy.


CONCLUSIONS
Adopting multiwavelength method may determine the appearant stability constant of multicomponential traditional drug. The determination of the stability constant of the inclusion complex can be used in traditional drug.
Ma
Kun-Fang
KF
Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China.
Ren
Yong
Y
Wang
Xuan
X
Mao
Lin
L
D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D004338:Drug Combinations; D031657:Forsythia / Q000737:chemistry; D019686:Lamiaceae / Q000737:chemistry; D027541:Mentha / Q000737:chemistry; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D047392:beta-Cyclodextrins / Q000032:analysis* / Q000737:chemistry
D004337:Drug Carriers; D004338:Drug Combinations; D009822:Oils, Volatile; D047392:beta-Cyclodextrins; C031215:betadex