Motor neuron disease and optic neuropathy after acute exposure to a methanol-containing solvent mixture.
A 34-years-old floor-layer developed optic neuropathy and motor neuron disease after being accidentally exposed to a solvent mixture containing methanol and other substances. Optic neuropathy is a complication of methanol poisoning, but the onset of a motor neuron disorder resembling amyotrophic lateral sclerosis after the exposure to these substances has not been previously described. The temporal onset of the clinical symptoms, biological plausibility, young age of the patient and absence of neurological disorders in the family history raises suspicion of a possible causative relationship.
Chiò
Adriano
A
Neuroscience, University of Turin, Italy. achio@usa.net
Herrero Hernandez
Elena
E
Mora
Gabriele
G
Valentini
Consuelo
C
Discalzi
Gianluigi
G
Pira
Enrico
E
D000328:Adult; D001931:Brain Mapping; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D000432:Methanol / Q000506:poisoning*; D016472:Motor Neuron Disease / Q000139:chemically induced* / Q000473:pathology; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000473:pathology; D011712:Pyramidal Tracts / Q000473:pathology; D012997:Solvents / Q000506:poisoning
D012997:Solvents; D000432:Methanol