title: Zyban for smoking cessation in a general practice setting: the response to an invitation to make a quit attempt.
abstract: The objective of this study was to assess the feasibility and success of Zyban as part of a moderately supported smoking cessation programme within UK general practice. Treatment was offered to 479 moderately dependent smokers (smoking 15 or more cigarettes per day) who had never used Zyban, and who had taken part in a previous NRT trial (the PATCH study). Main outcome measures were point prevalence and continuous abstinence from smoking at 6 and at 12 months. Two hundred and forty were excluded because of medical reasons or prescribing contraindication. Of the remainder (n=239) only 54 (23%) made an active quit attempt. Thirty percent (16/54) were abstinent at six months, and 22% (12/54) at 12 months (biochemically validated point prevalence rates). Age, socio-economic status, nicotine dependence, and genetic profile appeared to have little impact on success rates, but male quit-attempters were significantly more successful than female (40% vs. 10% at 12 months, p<0.05). In conclusion, a real-world smoking cessation programme using Zyban with moderate support within a general practice setting may achieve satisfactory quit rates without widening existing disparities in cessation.
authors.affiliation: Cancer Research UK General Practice Research Group, Clinical Pharmacology, Oxford University, UK. elaine.johnstone@clinpharm.ox.ac.uk
authors.forename: Elaine
authors.initials: E
authors.lastname: Johnstone
authors.forename: Kate
authors.initials: K
authors.lastname: Hey
authors.forename: Mark
authors.initials: M
authors.lastname: Drury
authors.forename: Sarah
authors.initials: S
authors.lastname: Roberts
authors.forename: Sarah
authors.initials: S
authors.lastname: Welch
authors.forename: Robert
authors.initials: R
authors.lastname: Walton
authors.forename: Mike
authors.initials: M
authors.lastname: Murphy
mesh_terms: D000328:Adult; D016642:Bupropion / Q000627:therapeutic use*; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D005194:Family Practice; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D019233:Retreatment; D012737:Sex Factors; D016540:Smoking Cessation / Q000379:methods*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D018765:Dopamine Uptake Inhibitors; D016642:Bupropion