Cold adaptation modulates Ca2+ signaling in brown preadipocytes.
One-week cold exposure of mice led to a 2-fold increase in the density of alpha1-adrenoceptors in brown adipose tissue. The density of alpha1-adrenoceptors returned to normal after adaptation to cold for 2 weeks. The reduced Ca2+ signaling in stem cells of brown fat activated via beta-adrenoceptors and cAMP was transformed into the Ca2+-system induced by alpha1-adrenoceptors and similar to that in mature brown adipocytes.
Baumuratov
A S
AS
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino.
Abzhalelov
B B
BB
Kramarova
L I
LI
Dolgacheva
L P
LP
Zinchenko
V P
VP
Bronnikov
G E
GE
D000064:Acclimatization; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000166:cytology*; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects; D002478:Cells, Cultured; D003080:Cold Temperature; D000242:Cyclic AMP / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009638:Norepinephrine / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D007093:Imidazoles; D011942:Receptors, Adrenergic, alpha; D000242:Cyclic AMP; D007545:Isoproterenol; C014282:cirazoline; D009638:Norepinephrine