title: Oesophageal pH monitoring is of limited value in the diagnosis of "reflux-cough".
abstract: Reflux-cough is a diagnosis based on demonstrating both gastro-oesophageal reflux and a positive response to anti-reflux therapy. The authors sought to determine early and long-term response to therapy in patients with a "positive" 24 h oesophageal pH study, and identify any features which might predict response. Patients with chronic cough were recruited from July 1998 to July 2002. Those with a positive pH study were given dietary advice and an 8-week trial of omeprazole (20 mg b.i.d.). Response was judged after 8 weeks (clinical follow-up), and at long-term follow-up (telephone questionnaire). A total of 146 patients underwent pH monitoring with 82 (56.2%) "positive" studies. Follow-up data was available in 60 patients, with 49 receiving anti-reflux therapy, of which 20 (40.8%) reported a positive treatment response. At long-term follow-up (median 30 months), there was a significantly lower response (14 out of 49, 28.5%), with no significant difference in either acid exposure times (distal/proximal) or symptom correlation between responders and nonresponders at early or long-term follow-up. In conclusion, despite "positive" pH studies, over half of the patients (55.1%) failed to respond to therapy. No features on pH monitoring accurately predicted response. Short-term response did not predict long-term response. The precise role for pH monitoring in the assessment of chronic cough remains to be defined.
authors.affiliation: Dept of Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK. neil@rnpatterson.idps.co.uk
authors.forename: R N
authors.initials: RN
authors.lastname: Patterson
authors.forename: B T
authors.initials: BT
authors.lastname: Johnston
authors.forename: J
authors.initials: J
authors.lastname: MacMahon
authors.forename: L G
authors.initials: LG
authors.lastname: Heaney
authors.forename: L P A
authors.initials: LP
authors.lastname: McGarvey
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D003371:Cough / Q000150:complications*; D004947:Esophagus / Q000503:physiopathology*; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008365:Manometry; D008991:Monitoring, Physiologic; D009853:Omeprazole / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole