title: Characterization of a new HLA-DRB1*01 allele (HLA-DRB1*010203) in a Caucasian Italian family by using sequence-based typing.
abstract: We report the identification of an HLA-DRB1*01 nucleotide sequence variant in three members of a Caucasian Italian family by using sequence-based typing. The nucleotide sequence of exon 2 observed in the new allele is identical to that of HLA-DRB1*010201 except in position 189 (codon 34) where the adenine of the consensus was replaced by a guanine and it was designated officially as HLA-DRB1*010203* by the WHO Nomenclature Committee.
authors.affiliation: Transfusion Service, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bontadini
authors.forename: S
authors.initials: S
authors.lastname: Manfroi
authors.forename: L
authors.initials: L
authors.lastname: Delfino
authors.forename: F
authors.initials: F
authors.lastname: Fruet
authors.forename: S
authors.initials: S
authors.lastname: Iannelli
authors.forename: A M
authors.initials: AM
authors.lastname: Parodi
authors.forename: G B
authors.initials: GB
authors.lastname: Ferrara
authors.forename: R
authors.initials: R
authors.lastname: Conte
mesh_terms: D000483:Alleles; D003062:Codon; D017931:DNA Primers; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D017354:Point Mutation; D017422:Sequence Analysis, DNA
chemical_list: D003062:Codon; D017931:DNA Primers; C497990:DRB1*01:02:03 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains