[Formation of the selected biochemical markers in the patients with atherosclerotic arterial obliteration and the coexistent infection with Chlamydia psittaci].
In the arterial wall which is atheromatously changed both basic EB and reticular RB bodies of Chlamydia bacteria may be present. The role of these micro-organisms in the pathogenesis of arteriosclerosis is not thoroughly recognized yet. It is unknown whether Chlamydia initiate or lead to the inflammation of the already existent disease process. That is why it is expedient to carry out the research determining the correlation between the presence of Chlamydia bacteria in the operated arteries and the formation of the selected biochemical indicators. During the operation the imprint specimen was taken from the arterial wall, which was subsequently painted using stamp's method. EB bodies were marked in the immunofluorescence test with the usage of specific antibodies. The concentration of C-reactive protein was marked with the help of the rocket immunoelectrophoresis. The examination of blood lipids and fibrinogens was conducted with the usage of a colorimetric method with the help of ready-made kits. On the basis of the obtained data two groups of patients were distinguished. The first group comprised 16 patients (26%); here elementary EB bodies were detected both in the imprint specimens and the blood serum. In all the patients assigned to the first group the presence of anti-Chlamydia antibodies in the blood serum was observed. The second group consisted of the remaining 47 patients (74%); here no currently lasting Chlamydia infection was stated. On the basis of the conducted research and statistic calculations it is justified to point the correlation between the concentration of C-reactive protein and HDL cholesterol in the group of patients with the detected Chlamydia bacteria in comparison to the group of patients with no infection. However no statistically significant relationship between the concentration of fibrinogen, total cholesterol, LDL cholesterol and triglycerides was observed in the relation to the analyzed groups.
Niedziela
Piotr
P
Katedra i Klinika Chirurgii Naczyrń Akademii Medycznej w Lublinie.
Kostro
Krzysztof
K
D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D001161:Arteriosclerosis / Q000382:microbiology*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D002691:Chlamydophila psittaci / Q000276:immunology* / Q000472:pathogenicity; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D000907:Antibodies, Bacterial; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D005340:Fibrinogen; D002097:C-Reactive Protein