title: Efficacy of artemether-lumefantrine treatment in patients with acute uncomplicated Falciparum malaria in Mayotte, a French collectivity of the Comoros Archipelago.
abstract: Mayotte is a French island located in the Comoros archipelago in the Indian Ocean. Due to the high level of resistance to chloroquine and sulfadoxine-pyrimethamine in this area, new therapeutic strategies are required. The aim was to assess and to document the efficacy of artemether-lumefantrine (AL) combination in four oral dosages. The follow-up was carried out during 21 days to monitor the antimalarial drug efficacy in an open trial in April-May, 2002. Results were obtained from 51 patients, aged from three to 46 years (12% less than five years). No case of therapeutic failure was observed. At day 2 after treatment, all the patients were apyretic and none of them had parasitaemia until day 21. This first therapeutic trial of the AL combination in the Indian Ocean sub-region shows that this association is safe, effective and rapid. AL should be an alternative treatment of uncomplicated malaria attacks in Comoros Archipelago, and will be of help to manage imported chloroquine-resistant falciparum malaria strains in Madagascar.
authors.affiliation: Groupe de Recherches sur le Paludisme, Institut Pasteur, Antananarivo, Madagascar.
authors.forename: A
authors.initials: A
authors.lastname: Tall
authors.forename: L A
authors.initials: LA
authors.lastname: Raharimalala
authors.forename: J F
authors.initials: JF
authors.lastname: Lepere
authors.forename: M C
authors.initials: MC
authors.lastname: Receveur
authors.forename: F
authors.initials: F
authors.lastname: Baur
authors.forename: L P
authors.initials: LP
authors.lastname: Rabarijaona
authors.forename: M
authors.initials: M
authors.lastname: Randrianarivelojosia
authors.forename: A
authors.initials: A
authors.lastname: Macarry
authors.forename: C
authors.initials: C
authors.lastname: Roussin
authors.forename: J M
authors.initials: JM
authors.lastname: Roussin
authors.forename: V
authors.initials: V
authors.lastname: Robert
authors.forename: F
authors.initials: F
authors.lastname: Ariey
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D000077549:Artemether; D037621:Artemisinins / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D017507:Comoros; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005449:Fluorenes / Q000627:therapeutic use*; D006801:Humans; D000078102:Lumefantrine; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D012717:Sesquiterpenes / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004983:Ethanolamines; D005449:Fluorenes; D012717:Sesquiterpenes; D000077549:Artemether; D000078102:Lumefantrine