The effect of clozapine on factors controlling glucose homeostasis.
BACKGROUND
This prospective study examines the effect of clozapine on factors determining glucose homeostasis.


METHODS
The sample consisted of all patients meeting DSM-IV criteria for schizophrenia who commenced clozapine treatment within the South London and Maudsley hospitals during 1 year (2000-2001). Growth hormone (GH), insulin-like growth factor-1 (IGF-1), and IGF binding protein-1 (IGFBP-1) were measured in 19 patients (10 female; mean age = 31.1 years [SD = 5.8]; 9 black British/African, 10 white British) before and after a mean of 2.5 (SD = 0.9) months of clozapine treatment.


RESULTS
Baseline IGFBP-1 was low. IGFBP-1, GH, and IGF-1 were not significantly changed by clozapine treatment.


CONCLUSIONS
Clozapine does not alter GH, IGF-1, or IGFBP-1 within 3 months of commencing treatment, indicating that alteration in glucose tolerance associated with clozapine treatment involves other mechanisms yet to be elucidated. Baseline abnormalities in IGFBP-1 indicate a preexisting susceptibility to glucoregulatory dysfunction.
Howes
Oliver D
OD
Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom. O.Howes@iop.kcl.ac.uk
Gaughran
Fiona P
FP
Amiel
Stephanie A
SA
Murray
Robin M
RM
Pilowsky
Lyn S
LS
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D015992:Body Mass Index; D003024:Clozapine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D019382:Human Growth Hormone / Q000097:blood / Q000187:drug effects; D006801:Humans; D007118:Immunoassay; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood / Q000187:drug effects; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000187:drug effects; D008163:Luminescent Measurements; D008297:Male; D011446:Prospective Studies; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy* / Q000378:metabolism
D014150:Antipsychotic Agents; D001786:Blood Glucose; D018970:Insulin-Like Growth Factor Binding Protein 1; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D003024:Clozapine