Clinical and functional consequences of platelet membrane glycoprotein polymorphisms.
The last several years have seen an abundance of studies of genetic risk factors for vascular disease, and platelet glycoprotein (GP) polymorphisms have been a primary focus of this area of research. This article reviews GP receptor polymorphisms, particularly those on GPIa-IIa (integrin alpha2beta1), GPIb-IX-V, GPIIb-IIIa (integrin alpha(IIb)beta3), and GPVI, and summarizes clinical and functional studies that have attempted to clarify their roles in human disease. Our focus is on recent work relevant to thrombotic and hemostatic processes and advances in pharmacogenetics. We consider issues affecting our ability to derive firm conclusions from these studies, and discuss future directions in this rapidly evolving area.
Yee
Donald L
DL
Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, Texas, USA.
Bray
Paul F
PF
D000483:Alleles; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D016678:Genome; D006239:Haplotypes; D006470:Hemorrhage; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D038982:Integrin alpha2beta1 / Q000235:genetics; D010597:Pharmacogenetics; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D038982:Integrin alpha2beta1; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; C098341:platelet membrane glycoprotein VI