title: No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population.
abstract: The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.
authors.affiliation: Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Yu
authors.forename: R
authors.initials: R
authors.lastname: Tao
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: Q
authors.initials: Q
authors.lastname: Xu
authors.forename: S-Z
authors.initials: SZ
authors.lastname: Liu
authors.forename: G-Z
authors.initials: GZ
authors.lastname: Ju
authors.forename: J-P
authors.initials: JP
authors.lastname: Shi
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Xie
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D051546:Cyclooxygenase 2; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008565:Membrane Proteins; D010741:Phospholipases A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D010741:Phospholipases A