title: Minimum inhibitory concentrations of some antimicrobial drugs against bacteria causing uterine infections in cattle.
abstract: The minimum inhibitory concentrations (MICs) of oxytetracycline, cephapirin, cephapirin/mecillinam, cefquinome, ceftiofur and enrofloxacin, candidate antibiotics for the principal bacteria associated with uterine infections: Escherichia coli, Arcanobacterium pyogenes and the anaerobic bacteria Fusobacterium necrophorum and Prevotella melaninogenicus, were determined by the agar dilution method. The bacteria were isolated from animals with clinical metritis and/or endometritis. For E coli, cefquinome and enrofloxacin had the lowest MIC90 and MIC50 values (< 0.06 microg/ml), and oxytetracycline and cephapirin had the highest values. For A pyogenes, oxytetracycline had the highest MIC50 value (16 microg/ml), but all the cephalosporins had values below 0.06 microg/ml. For the anaerobic bacteria, enrofloxacin and oxytetracycline had the highest MIC50 values but all the cephalosporins had values of 0.06 microg/ml or below.
authors.affiliation: Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield AL9 7TA.
authors.forename: I M
authors.initials: IM
authors.lastname: Sheldon
authors.forename: M
authors.initials: M
authors.lastname: Bushnell
authors.forename: J
authors.initials: J
authors.lastname: Montgomery
authors.forename: A N
authors.initials: AN
authors.lastname: Rycroft
mesh_terms: D000191:Actinomycetaceae / Q000254:growth & development; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000382:microbiology; D015169:Colony Count, Microbial / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial; D004716:Endometritis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D005675:Fusobacterium necrophorum / Q000187:drug effects; D008826:Microbial Sensitivity Tests / Q000662:veterinary*; D014591:Uterine Diseases / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents