A synthetic retinoid Am80 (tamibarotene) rescues the memory deficit caused by scopolamine in a passive avoidance paradigm.
Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders.
Shudo
Koichi
K
Research Foundation Itsuu Laboratory, Tokyo, Japan. kshudo@itsuu.or.jp
Kagechika
Hiroyuki
H
Yamazaki
Noriyuki
N
Igarashi
Masaharu
M
Tateda
Chiaki
C
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use; D001362:Avoidance Learning / Q000187:drug effects*; D001552:Benzazepines / Q000008:administration & dosage / Q000627:therapeutic use; D001565:Benzoates / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D018697:Nootropic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use*; D012601:Scopolamine; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014297:Trimethylsilyl Compounds / Q000008:administration & dosage / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D001552:Benzazepines; D001565:Benzoates; C422175:HX 630; D018697:Nootropic Agents; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D012176:Retinoids; C112689:TAC 101; D013764:Tetrahydronaphthalenes; D014297:Trimethylsilyl Compounds; C061133:tamibarotene; D012601:Scopolamine