title: The T-cell response to haptenated insulins. II. The antibody response.
abstract: As described in an accompanying paper, trinitrophenyl (TNP) modification of pork insulin (PI) at the A1 glycine position allows this molecule to stimulate a proliferative response in H-2b (B10) mice. We now show that this antigen stimulates low IgG responses in the same strain of mice. Our results show that T-cell help and proliferation may therefore be regulated independently.
authors.affiliation: Tumour Immunology Unit, Department of Biology (Medawar Building), University College London, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Flory
authors.forename: G R
authors.initials: GR
authors.lastname: Wallace
authors.forename: K
authors.initials: K
authors.lastname: Oettel
authors.forename: B M
authors.initials: BM
authors.lastname: Chain
mesh_terms: D019264:Adoptive Transfer / Q000379:methods; D000818:Animals; D000906:Antibodies / Q000097:blood / Q000276:immunology; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D002417:Cattle; D049109:Cell Proliferation; D007328:Insulin / Q000276:immunology / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000906:Antibodies; D007328:Insulin