Coexistence of Darier's disease and acrokeratosis verruciformis of Hopf.
Darier's disease and acrokeratosis verruciformis are inherited with the same pattern and they share similar clinical properties. We present a patient with both Darier's disease and acrokeratosis verruciformis. The patient had had brownish and skin-colored papules, initially on her face and neck, since the age of 25. Similar lesions had gradually spread to various parts of her body and lastly the dorsal aspect of her feet. On dermatological examination, brownish and skin-colored, 2 to 5 mm, keratotic papules were observed on her face, neck, both axillae, inframammary regions, and dorsa of the hands and feet. The nail examination revealed "V" shaped notches and longitudinal ridges on the fingers of both hands. The biopsy taken from the neck showed typical findings for Darier's disease. The biopsy from the dorsa of the left foot revealed the distinctive structures of acrokeratosis verruciformis. In this article the clinical and histopathological findings of these diseases are reviewed based on our patient.
Piskin
Suleyman
S
Department of Dermatology, Trakya University, School of Medicine, 22030- Edirne, Turkey. spiskin@trakya.edu.tr
Saygin
Aslihan
A
Doganay
Latife
L
Kircuval
Deniz
D
Gurkan
Eylem
E
D000169:Acrodermatitis / Q000473:pathology*; D000328:Adult; D001706:Biopsy; D007644:Darier Disease / Q000473:pathology*; D005260:Female; D006801:Humans; D007642:Keratosis / Q000473:pathology*; D012867:Skin / Q000473:pathology