title: In vitro pharmacodynamic characteristics of amphotericin B, caspofungin, fluconazole, and voriconazole against bloodstream isolates of infrequent Candida species from patients with hematologic malignancies.
abstract: Time-kill and postantifungal effect (PAFE) of amphotericin B, caspofungin, fluconazole, and voriconazole were determined against clinical isolates of Candida guilliermondii, Candida kefyr, and Candida lusitaniae. Azoles displayed fungistatic activity and no measurable PAFE, regardless of the concentration tested. Amphotericin B and caspofungin demonstrated concentration-dependent fungicidal activity, although amphotericin B only produced a significant dose-dependent PAFE against all isolates tested.
authors.affiliation: Center of Excellence on Aging, Room 27, 5th level, "G. D'Annunzio" University, Via Colle dell'Ara, 66100 Chieti, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Bonaventura
authors.forename: Ilaria
authors.initials: I
authors.lastname: Spedicato
authors.forename: Carla
authors.initials: C
authors.lastname: Picciani
authors.forename: Domenico
authors.initials: D
authors.lastname: D'Antonio
authors.forename: Raffaele
authors.initials: R
authors.lastname: Piccolomini
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000150:complications / Q000382:microbiology*; D000077336:Caspofungin; D015169:Colony Count, Microbial; D054714:Echinocandins; D015725:Fluconazole / Q000494:pharmacology*; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D007700:Kinetics; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D015725:Fluconazole; D000077336:Caspofungin; D065819:Voriconazole