Gastrointestinal stromal tumour of the duodenum in a 7-year-old boy.
We report a 7-year-old boy presenting with an acute upper gastrointestinal (GI) haemorrhage subsequently diagnosed to have a very rare duodenal gastrointestinal stromal tumour (GIST). Endoscopy, pertechnetate and red cell scans were negative. Abdominal US detected a 17-mm mass lesion of the third part of the duodenum. This was confirmed on CT and shown to be hypervascular on selective angiography. At laparotomy, a 20-mm submucosal duodenal lesion was found associated with mucosal ulceration. Immunohistochemical analysis revealed it to be positive for CD117 (c-KIT protein) consistent with a GIST. We emphasize the importance of a thorough abdominal US examination in children with GI haemorrhage and the consideration of GIST in the diagnosis after the common causes have been excluded.
Hughes
Jacqueline Ann
JA
Department of Radiology, Guy's Hospital NHS Trust, St Thomas' Street, London SE1 9RT, UK. jaqhughes@hotmail.com
Cook
Jane Valmai
JV
Said
Ahmid
A
Chong
Sonny K
SK
Towu
Emmanuel
E
Reidy
John
J
D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016099:Endoscopy, Gastrointestinal; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008551:Melena / Q000175:diagnosis; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D012509:Sarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit