title: Hallmarks of 'BRCAness' in sporadic cancers.
abstract: Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-repair processes. Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' - that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCA2-mutation carriers. These common properties might have important implications for the clinical management of these cancers.
authors.affiliation: The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Turner
authors.forename: Andrew
authors.initials: A
authors.lastname: Tutt
authors.forename: Alan
authors.initials: A
authors.lastname: Ashworth
mesh_terms: D019313:BRCA1 Protein / Q000502:physiology; D024682:BRCA2 Protein / Q000502:physiology; D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D005199:Fanconi Anemia / Q000235:genetics; D052236:Fanconi Anemia Complementation Group D2 Protein; D052219:Fanconi Anemia Complementation Group F Protein; D005260:Female; D020869:Gene Expression Profiling; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology; D010641:Phenotype; D016601:RNA-Binding Proteins / Q000502:physiology; D011995:Recombination, Genetic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein; D004273:DNA, Neoplasm; C499905:FANCD2 protein, human; C499901:FANCF protein, human; D052236:Fanconi Anemia Complementation Group D2 Protein; D052219:Fanconi Anemia Complementation Group F Protein; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins