Megakaryocytopoiesis under hypoxic conditions.
Acute and chronic hypoxia led to acceleration of proliferation and differentiation of bone marrow megakaryocytes and increase in their functional activity. The count of young cells in the peripheral blood increased during acute hypoxia. Chronic hypoxia led to increase in the number of old platelets with lower functional activity, which was accompanied by thrombocytosis.
Lebedeva
E V
EV
Institute for Ecology and Genetics of Microorganisms, Ekaterinburg Branch.
Yushkov
B G
BG
Chereshnev
V A
VA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D021461:Animals, Outbred Strains; D001792:Blood Platelets / Q000166:cytology; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D002455:Cell Division; D048429:Cell Size; D004837:Epinephrine / Q000494:pharmacology; D005269:Femur / Q000166:cytology; D000860:Hypoxia / Q000097:blood* / Q000473:pathology*; D008297:Male; D008533:Megakaryocytes / Q000166:cytology* / Q000378:metabolism*; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D051381:Rats; D013922:Thrombocytosis / Q000209:etiology; D034061:Thrombopoiesis
D000244:Adenosine Diphosphate; D004837:Epinephrine