title: Studies in otitis media: Children's Hospital of Pittsburgh-University of Pittsburgh progress report--2004.
abstract: OBJECTIVE
  The present Progress Report has summarized the key otitis media clinical trials and laboratory studies conducted since 1969 by investigators at the Children's Hospital of Pittsburgh-University of Pittsburgh (Pittsburgh, PA).
  
  
  METHODS
  Review.
  
  
  METHODS
  Included in the discussion are the following: 1) studies of the epidemiology and risk factors; 2) anatomy and pathology of the eustachian tube-middle ear from human temporal bone histopathological specimens; 3) physiology and pathophysiology of the eustachian tube-middle ear in humans and animal models; 4) pathogenesis; 5) otitis media in special populations (e.g., patients with cleft palate, Native Americans, patients with Down syndrome); 6) microbiology; 7) diagnosis; 8) outcomes of randomized clinical trials that evaluated efficacy of nonsurgical and surgical methods of treatment and prevention; 9) studies of certain complications and sequelae (e.g., effect of middle-ear effusion on hearing, early child development, and the vestibular system; chronic suppurative otitis media). Also included are relevant summary tables and 256 references.
authors.affiliation: Department of Pediatric Otolaryngology, University of Pittsburgh School of Medicine-Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Bluestone
mesh_terms: D000233:Adenoidectomy; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000473:pathology / Q000503:physiopathology; D005064:Eustachian Tube / Q000473:pathology / Q000503:physiopathology; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008876:Middle Ear Ventilation; D009225:Myringoplasty; D014663:Nasal Decongestants / Q000627:therapeutic use; D010033:Otitis Media / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D010034:Otitis Media with Effusion / Q000175:diagnosis; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D006633:Histamine Antagonists; D014663:Nasal Decongestants