Physical and functional interaction between integrins and hERG potassium channels.
Integrins are adhesion receptors capable of transmitting intracellular signals that regulate many different cellular functions. Among integrin-mediated signals, the activation of ion channels can be included. We demonstrated that a long-lasting activation of hERG (human ether-a-go-go-related gene) potassium channels occurs in both human neuroblastoma and leukaemia cells after the activation of the beta1 integrin subunit. This activation is apparently a determining factor inducing neurite extension and osteoclastic differentiation in both the cell types. More recently, we provided evidences that beta1 integrins and hERG channels co-precipitate in both the cell types. Preliminary results suggest that a macromolecular signalling complex indeed occurs between integrins and the hERG1 protein and that hERG channel activity can modulate integrin downstream signalling.
Arcangeli
A
A
Department of Experimental Pathology and Oncology, University of Firenze, Italy. annarosa.arcangeli@unifi.it
Becchetti
A
A
Cherubini
A
A
Crociani
O
O
Defilippi
P
P
Guasti
L
L
Hofmann
G
G
Pillozzi
S
S
Olivotto
M
M
Wanke
E
E
D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism*; D045744:Cell Line, Tumor; D051638:Ether-A-Go-Go Potassium Channels; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D007938:Leukemia / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism*; D011485:Protein Binding; D015398:Signal Transduction
D027682:Cation Transport Proteins; D051638:Ether-A-Go-Go Potassium Channels; D016023:Integrins; C092509:KCNH6 protein, human; D024642:Potassium Channels, Voltage-Gated; D011188:Potassium