Hemostatic abnormalities and changes following bone marrow transplantation.
Hemostatic parameters were examined in 39 patients who underwent allogeneic bone marrow transplantation (BMT). Twenty-six patients survived and 13 patients died within 6 months after BMT. The main causes of death were acute graft-versus-host disease (GVHD: n=6), veno-occlusive disease (VOD: n=2), and thrombotic microangiopathy (TMA: n=2). Plasma levels of D-dimer and thrombomodulin (TM) were significantly elevated in the non-survivor group. Plasma levels of soluble fibrin (SF) and Fas were significantly elevated in the non-survivor group at 1 to 4 weeks after BMT. Plasma levels of thrombin-antithrombin complex (TAT), D-dimer, and tissue plasminogen activator-plasminogen activator inhibitor-1 complex (tPA-PAI-1 complex) were significantly elevated in patients with complications after BMT. Plasma levels of TAT, D-dimer, and tPA-PAI-1 complex were significantly elevated in patients with GVHD. These results suggest that abnormalities of hemostatic parameters might predict poor outcomes or complications in patients with BMT.
Matsumoto
Takeshi
T
Second Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Japan.
Wada
Hideo
H
Nishiyama
Hiroyoshi
H
Hirano
Tomomi
T
Sakakura
Miho
M
Nishii
Kazuhiro
K
Masuya
Masahiro
M
Kageyama
Shinichi
S
Tamaki
Shigehisa
S
Nakase
Kazunori
K
Nobori
Tsutomu
T
Shiku
Hiroshi
H
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001779:Blood Coagulation Factors / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000401:mortality; D002423:Cause of Death; D005260:Female; D005337:Fibrin / Q000032:analysis; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000097:blood / Q000175:diagnosis; D019337:Hematologic Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy*; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D014184:Transplantation, Homologous; D014652:Vascular Diseases / Q000175:diagnosis / Q000209:etiology; D019014:fas Receptor / Q000097:blood
D015415:Biomarkers; D001779:Blood Coagulation Factors; D019014:fas Receptor; D005337:Fibrin