[Human papillomavirus (HPV) infection and its relation with squamous cell carcinoma of the mouth and oropharynx].
OBJECTIVE
To establish a connection between infection by the human papilloma virus (HPV) and development of malignant (squamous cell carcinoma) and benign lesions (epithelial hyperplasia papillomatosis and papilloma) of the oral cavity and oropharynx.


METHODS
A retrospective study of 66 blades and paraffin blocks with biopsy tissue fixed with formalin. This material, collected in 2002, refers to a group of 44 men (66.7%) and 22 women (33.3%) with ages ranging from 11 to 100 years, with confirmed diagnoses of squamous cell carcinoma in 38 cases, of epithelial hyperplasia papillomatosis in 20 cases and of papillomas in 8 cases. This material was analyzed by immunohistochemistry and the presence of viral DNA in the biopsy samples was determined.


RESULTS
Presence of the viral DNA (HPV) in 16 of the 38 cases of carcinoma (42.5%), 19 in 20 cases of hyperplasia (95%) and 8 in 8 cases of papilloma (100%) was detected.


CONCLUSIONS
The samples in this study show the predominant incidence of the HPV in the epithelial hyperplasia papillomatosis and papilloma in relation to squamous cell carcinoma. This last lesion, on the other hand, did not show statistical correlation to the HPV.
Tinoco
José Alberto
JA
Departamento de Cirurgia de Cabeça, Pescoço, e Otorrinolaringologia, Hospital Heliópolis, São Paulo, SP.
Silva
Alessandra Furtado da
AF
Oliveira
Carlos Alberto Basílio de
CA
Rapoport
Abrão
A
Fava
Antonio Sérgio
AS
Souza
Ricardo Pires de
RP
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D002648:Child; D004812:Epidemiologic Methods; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000473:pathology / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000821:virology*; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000821:virology*; D010212:Papilloma / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications*; D012737:Sex Factors