title: NF-kappaB signaling: flipping the switch with polyubiquitin chains.
abstract: Protein modification by ubiquitin has emerged as an important cellular regulatory mechanism. Recent studies illustrate the surprising ways in which polyubiquitin chains are manipulated in the regulation of NF-kappaB signaling.
authors.affiliation: Yale University, Department of Molecular Biophysics & Biochemistry, 266 Whitney Avenue, P.O. Box 208114 New Haven, Connecticut 06520-8114, USA.
authors.forename: Tommer
authors.initials: T
authors.lastname: Ravid
authors.forename: Mark
authors.initials: M
authors.lastname: Hochstrasser
mesh_terms: D005786:Gene Expression Regulation; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism* / Q000502:physiology; D010766:Phosphorylation; D025821:Polyubiquitin / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; D025821:Polyubiquitin