Damage signaling: RecQ sends an SOS to you.
The DNA helicase RecQ is required for proper induction of the SOS response to replication stress in Escherichia coli. Unwinding of stalled replication forks by RecQ family helicases in bacteria, and possibly in eukaryotes, may provide a means of damage signaling and recovering stalled replication forks.
Heyer
Wolf-Dietrich
WD
Division of Biological Sciences, Section of Microbiology, Center for Genetics and Development, University of California at Davis, Davis, California 95616-8665, USA. wdheyer@ucdavis.edu
D000251:Adenosine Triphosphatases / Q000378:metabolism* / Q000502:physiology; D004265:DNA Helicases / Q000378:metabolism* / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D004926:Escherichia coli; D008957:Models, Genetic; D053484:RecQ Helicases; D011995:Recombination, Genetic / Q000502:physiology*; D013014:SOS Response, Genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D000251:Adenosine Triphosphatases; C506724:RecQ protein, E coli; D004265:DNA Helicases; D053484:RecQ Helicases