[Anti-arrhythmic effect of starfish sterol].
OBJECTIVE
To study the effect of modified starfish sterol [C03, succinic acid (5-epiandroene-17-one-3beta-ol) diester] on experimental arrhythmias.


METHODS
Arrhythmias were induced by drugs (Aco, Oua, BaCl2 and adrenalin) i.v., ligating the left anterior descending coronary artery and electricity.


RESULTS
C03 71.4 mg x kg(-1) (ig) was shown to increase the dose of Oua inducing VP, VT, VF and CA in guinea pigs (P < 0.01); C03 (26.8, 80.4 mg x kg(-1)) was found to increase the dose of Aco inducing VF and CA in rats (P < 0.01); C03 (8.9, 26.8, 80.4 mg x kg(-1)) increase the dose of barium chloride and delay the onset time of ventricular arrhythmias (P < 0.01); C03 (14.1, 42.3 mg x kg(-10) shorten time of recovering induced by adrenalin in rabbits (P < 0.01); C03 (80.4 mg x kg(-1)) was shown to reduce the number of ventricular arrhythmias induced by coronary artery ligation in rats (P < 0.05), C03 increase VFT induced by electricity in rabbits, VFT of C03 14.1 mg x kg(-1) increased from (5.1 +/- 2.5) V to (11.0 +/- 2.7) V (P < 0.01), 42.3 mg x kg(-1) increased from (6.1 +/- 1.7) V to (15 +/- 5) V (P < 0.01).


CONCLUSIONS
Starfish sterol has anti-arrhythmic effect.
Xu
Dong-Hui
DH
Laboratory of Chinese Medicine and Marine Drugs, School of Pharmaceutical Sciences, SUN Yat-sen University, Guangzhou 510275, China. lsdb@zsu.edu.cn
Zhu
Liang
L
Mei
Xue-Ting
XT
Chen
Li-Qiong
LQ
Meng
Xue-Qiang
XQ
Wang
Sheng
S
Xu
Shi-Bo
SB
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D017609:Barium Compounds; D002415:Cats; D002712:Chlorides; D004837:Epinephrine; D006168:Guinea Pigs; D008419:Materia Medica / Q000302:isolation & purification / Q000627:therapeutic use*; D051379:Mice; D010042:Ouabain; D011817:Rabbits; D051381:Rats; D013215:Starfish / Q000737:chemistry; D013261:Sterols / Q000302:isolation & purification / Q000627:therapeutic use*; D014693:Ventricular Fibrillation / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D017609:Barium Compounds; D002712:Chlorides; D008419:Materia Medica; D013261:Sterols; C024986:barium chloride; D010042:Ouabain; D000157:Aconitine; D004837:Epinephrine