Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.
We report the first total synthesis of jiadifenin (1), the establishment of a modality for its biological evaluation, and the discovery of apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1.
Cho
Young Shin
YS
Laboratory for Bioorganic Chemistry and Laboratory of Biochemistry and Pharmacology, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
Carcache
David A
DA
Tian
Yuan
Y
Li
Yue-Ming
YM
Danishefsky
Samuel J
SJ
D000818:Animals; D009414:Nerve Growth Factors / Q000138:chemical synthesis / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology
D009414:Nerve Growth Factors; D012717:Sesquiterpenes; C457979:jiadifenin