title: Analgesic effects of 5-HT3 receptor antagonists.
abstract: Current research suggests an involvement of 5-HT3 receptors in peripheral and central perception and processing of pain as well as in inflammation. Tropisetron and other selective 5-HT3 receptor antagonists have been used successfully for pain reduction and treatment of related symptoms in patients diagnosed with fibromyalgia. This article proposes a concept of the underlying pathophysiology and mechanisms of action of 5-HT3 receptor antagonists in the context of the relevant clinical data on their application in patients with rheumatic disease.
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Riering
authors.forename: C
authors.initials: C
authors.lastname: Rewerts
authors.forename: W
authors.initials: W
authors.lastname: Zieglgänsberger
mesh_terms: D000698:Analgesia; D006801:Humans; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D044406:Receptors, Serotonin, 5-HT3 / Q000502:physiology; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists / Q000627:therapeutic use*
chemical_list: D044406:Receptors, Serotonin, 5-HT3; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists