[Influence of human genetic variants on resistance and immunity against malaria].
Certain human genetic variants occur on-ly in areas endemic for malaria. They protect against fatal malaria complications and cause inhibition of growth or development of malaria parasites in vitro. Among these are the haemoglobins (Hb) S and C, alpha-thalassaemias, glucose-6-phosphate dehydrogenase deficiency, as well as a deletion in the erythrocyte band 3 protein. Evidence for similar effects has been obtained for HbD and HbE, glycophorins A and C as well as for a number of immunologically relevant molecules such as human leukocyte antigens,tumour-necrosis-factor a and the inducible nitric oxide synthase. The findings indicate that malaria in endemic areas has caused a substantial selection of the human genome.
May
J
J
Bernhart-Nocht-Institut für Tropenmedizin, Hamburg.
Horstmann
R
R
D014644:Genetic Variation; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000276:immunology; D006021:Glycophorins / Q000276:immunology; D006451:Hemoglobin, Sickle / Q000276:immunology; D006454:Hemoglobins / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D016778:Malaria, Falciparum / Q000235:genetics* / Q000276:immunology*; D019001:Nitric Oxide Synthase / Q000276:immunology; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D017085:alpha-Thalassemia / Q000276:immunology
D006021:Glycophorins; D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D014409:Tumor Necrosis Factor-alpha; D019001:Nitric Oxide Synthase