title: [Experimental study on anti-pyretic effect of gegen qin lian decoction and its compounds].
abstract: OBJECTIVE
  To investigate composition principles of Gegen Qin Lian decoction through anti-pyretic experiment.
  
  
  METHODS
  Pharmacological effects of different compounds of Gegen Qin Lian decoction according to six hours temperature response index (TRI6) and average top temperature response height (deltaT) after the decoction was given to feverish animal model by inactived bacteria suspension.
  
  
  RESULTS
  As for reducing six hour temperature response index, Scutellaria baicalensis root was the main effective drug. Pueraria lobata root could enforce the effect while Coptis chinensis rhizome and Glycyrrhiza uralensis root counteracted it. As for reducing average top temperature response height, the Effects of four herbal drugs were the same as for TRI6.
  
  
  CONCLUSIONS
  Of the compounds of Gegen Qin Lian decoction, as to the pharmcological anti-pyretic effects, the best one is the compound of Scutellaria baicalensis and Pueraria lobata roots.
authors.affiliation: Department of Chinese Drugs Pharmacology of First Military Medical University, Guangzhou 510515, China. yulzh@fimmu.com
authors.forename: Lin-Zhong
authors.initials: LZ
authors.lastname: Yu
authors.forename: Jie-yong
authors.initials: JY
authors.lastname: Wu
authors.forename: Jia-Bo
authors.initials: JB
authors.lastname: Luo
authors.forename: Xu-Guang
authors.initials: XG
authors.lastname: Huang
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Shao
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D039323:Coptis / Q000737:chemistry; D004338:Drug Combinations; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli; D004927:Escherichia coli Infections; D005334:Fever / Q000188:drug therapy / Q000382:microbiology; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D008297:Male; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D031364:Scutellaria baicalensis / Q000737:chemistry
chemical_list: D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal