Trends in AIDS-defining and non-AIDS-defining malignancies among HIV-infected patients: 1989-2002.
In a comparison of rates of acquired immunodeficiency syndrome (AIDS)-defining malignancies (ADMs) for 1989-1996 versus 1997-2002, we found a decrease in ADMs (rate ratio, 0.31; P<.0001) and a significant increase in non-AIDS-defining malignancies (non-ADMs; rate ratio, 10.87; P<.0002). The mean CD4 cell count was lower among patients with ADMs than among those with non-ADMs. A longer duration of survival during highly active antiretroviral therapy might explain the increasing incidence of non-ADMs.
Bedimo
Roger
R
University of Alabama at Birmingham, USA. roger.bedimo@med.va.gov
Chen
Ray Y
RY
Accortt
Neil A
NA
Raper
James L
JL
Linn
Carol
C
Allison
Jeroan J
JJ
Dubay
John
J
Saag
Michael S
MS
Hoesley
Craig J
CJ
D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D012307:Risk Factors
D019380:Anti-HIV Agents