title: Sequential therapy using cyclosporine and acitretin for treatment of total body psoriasis.
abstract: Systemic sequential therapy using cyclosporine and acitretin is a novel strategy that can provide quick resolution and maintenance in refractory cases of psoriasis. We describe the case of a patient with a psoriatic flare over 98% of his body, despite methotrexate therapy. Implementing sequential therapy with cyclosporine and acitretin maximized the benefit of each treatment and allowed for rapid improvement with minimal risk of toxicity.
authors.affiliation: Department of Family Practice, Bayne-Jones Army Community Hospital, Fort Polk, Louisiana, USA.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Short
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Vaughan
mesh_terms: D017255:Acitretin / Q000008:administration & dosage / Q000627:therapeutic use*; D000279:Administration, Cutaneous; D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D007641:Keratolytic Agents; D016572:Cyclosporine; D017255:Acitretin