title: Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, China.
abstract: Four cases of severe acute respiratory syndrome (SARS) that occurred from December 16, 2003, to January 8, 2004, in the city of Guangzhou, Guangdong Province, China, were investigated. Clinical specimens collected from these patients were tested by provincial and national laboratories in China as well as members of the World Health Organization SARS Reference and Verification Laboratory Network in a collaborative effort to identify and confirm SARS-associated coronavirus (SARS-CoV) infection. Although SARS-CoV was not isolated from any patient, specimens from three patients were positive for viral RNA by reverse transcription-polymerase chain reaction assay, and all patients had detectable rises in SARS-CoV-specific antibodies. This study shows the effectiveness of a collaborative, multilaboratory response to diagnose SARS.
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Liang
authors.forename: Qiuxia
authors.initials: Q
authors.lastname: Chen
authors.forename: Jianguo
authors.initials: J
authors.lastname: Xu
authors.forename: Yufei
authors.initials: Y
authors.lastname: Liu
authors.forename: Wilina
authors.initials: W
authors.lastname: Lim
authors.forename: J S M
authors.initials: JS
authors.lastname: Peiris
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Anderson
authors.forename: Li
authors.initials: L
authors.lastname: Ruan
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Biao
authors.initials: B
authors.lastname: Kan
authors.forename: Biao
authors.initials: B
authors.lastname: Di
authors.forename: Peter
authors.initials: P
authors.lastname: Cheng
authors.forename: K H
authors.initials: KH
authors.lastname: Chan
authors.forename: Dean D
authors.initials: DD
authors.lastname: Erdman
authors.forename: Shuyan
authors.initials: S
authors.lastname: Gu
authors.forename: Xinge
authors.initials: X
authors.lastname: Yan
authors.forename: Weili
authors.initials: W
authors.lastname: Liang
authors.forename: Duanhua
authors.initials: D
authors.lastname: Zhou
authors.forename: Lia
authors.initials: L
authors.lastname: Haynes
authors.forename: Shumin
authors.initials: S
authors.lastname: Duan
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Han
authors.initials: H
authors.lastname: Zheng
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Suxiang
authors.initials: S
authors.lastname: Tong
authors.forename: Dexin
authors.initials: D
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Fang
authors.forename: Pengzhe
authors.initials: P
authors.lastname: Qin
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002681:China; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000032:analysis; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics / Q000276:immunology; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis*
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral