A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.
Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23-q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. For the purpose of this analysis, an additional 18 families were recruited from the Saguenay-Lac-St-Jean region and pooled to our previous sample to improve its statistical power, giving a total of 394 sampled individuals. This work confirms the presence of a susceptibility locus for affective disorder on chromosome 12q24 with parametric LOD score value of 3.35 at D12S378 when pedigrees were broken into nuclear families and analysed under a recessive segregation model. This result was supported by neighbouring markers and by a LOD score value of 5.05 at D12S378 under model-free analysis. Other regions of lower interest were indicated on chromosomes 2, 5, 7, 9, 10, 17 and 20.
Shink
E
E
Neuroscience, CHUL Research Centre and Laval University, CHUQ Pavillon CHUL, Ste-Foy, Québec, Canada.
Morissette
J
J
Sherrington
R
R
Barden
N
N
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D008126:Lod Score; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D008957:Models, Genetic; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics; D011792:Quebec