[Mechanisms of muscovite on gastric mucosal protective effect].
OBJECTIVE
To explore the mechanisms of muscovite gastric mucosal protective effect.


METHODS
Rat model of chronic gastritis were used. After gastric mucosal injury was induced, the rats were divided into 6 groups and were treated with different drugs. 2 weeks later, the tissue and blood samples were obtained and measured.


RESULTS
The general conditions, the observations under macroscopy, microscope and electron microscope of the middle and high dose of muscovite groups resembled those of the normal group. Their PH levels were higher than those of the model group, and the rates of intestinal metaplasia were lower, but the PGE2 level of the middle dose of muscovite group was the highest.


CONCLUSIONS
Muscovite can be adsorbed on the surface of the gastric mucosa. It has gastric mucosal protective effect by improving excretion of mucus and synthesis of PGE2 in gastric mucosa, restraining gastric acid, reversing of intestinal metaplasia and decreasing inflammation cells.
Qian
Yun
Y
Gastroenterology Laboratory of Sir Run Run Shaw Clinic Medical Center, Zhejiang University, Hangzhou 310016, China.
Si
Jian-Min
JM
Wang
Liang-Jing
LJ
Chen
Shu-Jie
SJ
Zhu
You-Fa
YF
D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D015232:Dinoprostone / Q000097:blood; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000473:pathology / Q000648:ultrastructure*; D005756:Gastritis / Q000097:blood / Q000139:chemically induced / Q000473:pathology*; D006863:Hydrogen-Ion Concentration; D008419:Materia Medica / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D017680:Potassium Compounds / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017640:Silicates / Q000494:pharmacology*; D012980:Sodium Salicylate
D017607:Aluminum Compounds; D008419:Materia Medica; D017680:Potassium Compounds; D020011:Protective Agents; D017640:Silicates; C016024:orthoclase; D015232:Dinoprostone; D012980:Sodium Salicylate