title: Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome: role of obesity.
abstract: Neuropeptide Y (NPY) and leptin are two peptides involved in the regulation of body weight, energy balance, and sympathetic tone. This study investigates the independent role of apneas and obesity on NPY and leptin plasma levels in patients with obstructive sleep apnea syndrome (OSAS). To this end we compared their values in 23 obese (body mass index > 30 kg/m2) and 24 nonobese (body mass index < 27 kg/m2) patients with OSAS, and in 19 obese and 18 nonobese control subjects without OSAS. Patients who used continuous positive airway pressure for more than 4 hours/night were reexamined 3 and 12 months later. We found that NPY levels were increased (p < 0.01) in patients with OSAS independently of obesity. Leptin levels were also increased in OSAS but this was mostly associated to obesity. Continuous positive airway pressure treatment reduced NPY levels in all patients and leptin levels only in nonobese patients (p < 0.01). We concluded that NPY and leptin plasma levels are increased in patients with OSAS. Yet, whereas the former appear independent of obesity, the latter are mostly associated with obesity.
authors.affiliation: Servei de Anàlisis Cliniques and Pneumologia, Hospital Universitari Son Dureta, Institut Universitari de Ciencies de la Salut, Palma de Mallorca, Spain.
authors.forename: Antonia
authors.initials: A
authors.lastname: Barceló
authors.forename: Ferran
authors.initials: F
authors.lastname: Barbé
authors.forename: Elena
authors.initials: E
authors.lastname: Llompart
authors.forename: Mónica
authors.initials: M
authors.lastname: de la Peña
authors.forename: Joaquin
authors.initials: J
authors.lastname: Durán-Cantolla
authors.forename: Antoni
authors.initials: A
authors.lastname: Ladaria
authors.forename: Margalida
authors.initials: M
authors.lastname: Bosch
authors.forename: Lourdes
authors.initials: L
authors.lastname: Guerra
authors.forename: Alvar G N
authors.initials: AG
authors.lastname: Agustí
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers; D016022:Case-Control Studies; D045422:Continuous Positive Airway Pressure; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood*; D009765:Obesity / Q000097:blood; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D020738:Leptin; D009478:Neuropeptide Y