Formation of a stable 14-helix in short oligomers of furanoid cis-beta-sugar-amino acid.
Oligomers of a new class of sugar amino acids (SAA) using a xylofuranoic acid has been shown to generate a robust 14-helix. The design involved the use of xylofuranose with a cis arrangement between the amine and carboxyl groups to promote the adoption of a 14-helix instead of a mixed 12/10-helix observed in a sugar oligomer using a ribofuranoic acid and beta-Ala. The observation of a stable right-handed 14-helix in a cis-SAA is unprecedented.
Chandrasekhar
Srivari
S
Indian Institute of Chemical Technology, Hyderabad 500 007, India. srivaric@iict.res.in
Reddy
Marepally Srinivasa
MS
Jagadeesh
Bharatam
B
Prabhakar
Anabathula
A
Ramana Rao
Mallem H V
MH
Jagannadh
Bulusu
B
D000596:Amino Acids / Q000737:chemistry*; D000606:Amino Sugars / Q000737:chemistry*; D002942:Circular Dichroism; D005663:Furans / Q000737:chemistry*; D006860:Hydrogen Bonding; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013816:Thermodynamics
D000596:Amino Acids; D000606:Amino Sugars; D005663:Furans; D009842:Oligopeptides