Two-year clinical follow-up results of intracoronary radiation therapy with rhenium-188-diethylene triamine penta-acetic acid-filled balloon.
We investigated the 2-year clinical follow-up results as well as 6-month angiographic and clinical follow-up results of intracoronary radiation therapy using a rhenium-188-diethylene triamine penta-acetic acid ((188)Re-DTPA)-filled balloon system. The study comprised of 161 patients with significant de novo (83%) or in-stent restenosis (17%) lesions. Irradiation to deliver 17.6 Gy at a depth of 1.0 mm into the vessel wall was carried out after successful intervention. At 6-month follow-up, binary restenosis developed with significantly lower frequency in the radiation group than in the control group (24.3% vs. 46.3%; P = 0.009), although target lesion revascularization rate did not show significant benefit. At 2-year follow-up, cumulative target lesion revascularization rate was not significantly different between radiation group (n = 86) and control group (n = 75; 20.0% vs. 26.0%; P = 0.368). The rate of major adverse cardiac events including death, myocardial infarction, and target lesion revascularization did not show significant difference between two groups either (22.3% vs. 30.1%; P = 0.266). In conclusion, although significant reduction in restenosis rate was noted at 6-month angiographic follow-up, intracoronary radiation therapy mostly in patients with de novo lesion did not show significant clinical benefit in 6-month and 2-year follow-up results. The benefit was noted only in a small subgroup of patients with in-stent restenosis.
Cho
Young-Seok
YS
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Kim
Myung-A
MA
Hwang
Kyung-Kuk
KK
Koo
Bon-Kwon
BK
Oh
Seil
S
Chae
In-Ho
IH
Kim
Hyo-Soo
HS
Lee
Dong-Soo
DS
Oh
Byung-Hee
BH
Lee
Myoung-Mook
MM
Park
Young-Bae
YB
Choi
Yun-Shik
YS
D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000532:radiotherapy; D023921:Coronary Stenosis / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid; D011446:Prospective Studies; D015641:Radiography, Interventional; D011868:Radioisotopes / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D012211:Rhenium / Q000008:administration & dosage*
D011868:Radioisotopes; D012211:Rhenium; D004369:Pentetic Acid