title: The family pictures test as a measure of impaired feature binding in schizophrenia.
abstract: We investigated the use of the Family Pictures test from the Wechsler Memory Scale III as a measure of the ability to bind the multiple features of a complex visual scene in a study group of 77 patients with schizophrenia and 44 healthy controls. Patients demonstrated impaired recall of all scene features as well as a reduction in the number of features recalled for each remembered character. Secondary analyses using patients and controls matched for character recall also showed reduced feature binding in the patient group. Such feature binding deficits likely implicate hippocampal dysfunction, consistent with neuroimaging evidence of structural and functional compromise of the medial temporal lobe in schizophrenia.
authors.affiliation: Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA. jgold@mprc.umaryland.edu
authors.forename: James M
authors.initials: JM
authors.lastname: Gold
authors.forename: Michael S
authors.initials: MS
authors.lastname: Poet
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Wilk
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buchanan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology*; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010364:Pattern Recognition, Visual / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014888:Wechsler Scales / Q000706:statistics & numerical data