title: Low-dose tiagabine effectiveness in anxiety disorders.
abstract: BACKGROUND
  Gamma-aminobutyric acid (GABA), the predominant inhibitory neurotransmitter of the central nervous system, is involved in the pathophysiology of a wide variety of disorders, including anxiety. Tiagabine hydrochloride acts as a selective GABA reuptake inhibitor (SGRI).
  
  
  RESULTS
  Consecutive patients were offered tiagabine in 1-mg incremental doses for the treatment of anxiety, primarily generalized anxiety disorder. Individuals failing anxiety treatment with benzodiazepines, selective serotonin reuptake inhibitors, and buspirone, and/or with a strong family or personal history of substance abuse were allowed trials. The SGRI tiagabine improved anxiety and was well tolerated by adult patients with generalized anxiety disorder as well as one patient with anxiety secondary to acute antidepressant withdrawal. One disinhibition treatment failure is also discussed.
  
  
  CONCLUSIONS
  In acute anxiety treatment, very low initial dosing with gradual increases may be sufficient for anxiety effects, when compared with the higher doses of tiagabine used in epilepsy treatment. Tiagabine may be useful in the treatment of generalized anxiety disorder.
authors.affiliation: Professional Medical Services of Naples, Naples, Florida, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Schaller
authors.forename: John
authors.initials: J
authors.lastname: Thomas
authors.forename: David
authors.initials: D
authors.lastname: Rawlings
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001007:Anxiety / Q000150:complications; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D003865:Major Depressive Disorder / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014179:Neurotransmitter Uptake Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D009557:Nipecotic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D000078308:Tiagabine; D016896:Treatment Outcome
chemical_list: D014179:Neurotransmitter Uptake Inhibitors; D009557:Nipecotic Acids; D000078308:Tiagabine