title: [Correlation of the expression of MDR genes and MDR genes-coded product with prognosis in laryngopharyngeal malignant melanoma].
abstract: OBJECTIVE
  To study the correlation of expression implication of MDR genes (GST-pi and Topo II) and MDR gene-coded product (Pgp) with prognosis in laryngopharyngeal malignant melanoma.
  
  
  METHODS
  Using immunohistochemical S-P method,expression of GST-pi, Topo II and Pgp was detected in 28 cases of laryngopharyngeal malignant melanoma. The relationship between GST-pi, Topo II, Pgp and clinicopathological features, prognosis of the tumors were also analyzed.
  
  
  RESULTS
  The positive rates of Pgp, GST-pi and Topo II were 35.7%, 57.1% and 46.4% respectively in 28 cases of laryngopharyngeal malignant melanoma, without significant difference (P > 0.05). The positive rates of Pgp, GST-pi and Topo II were not correlated with sex,age, size of tumor and Clark's grade, Breslow's grade (P > 0.05), but AJC grade and prognosis (P < 0.05).
  
  
  CONCLUSIONS
  Expression of Pgp,GST-pi and Topo II may be the chief mechanism of multi-drug resistance. Detection of multi-drug resistance genes is of necessity and feasibility when predicting the effect of chemotherapy.
authors.affiliation: Department of Otolaryngology, Affiliated First Hospital, Fujian Medical University, Fuzhou 350005.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Tianhai
authors.initials: T
authors.lastname: Ji
authors.forename: Liqing
authors.initials: L
authors.lastname: Yao
authors.forename: Jingsong
authors.initials: J
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Deng
authors.forename: Zaigen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D004250:DNA Topoisomerases, Type II / Q000096:biosynthesis*; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D019450:Genes, MDR / Q000235:genetics*; D051549:Glutathione S-Transferase pi / Q000096:biosynthesis*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D051549:Glutathione S-Transferase pi; D004250:DNA Topoisomerases, Type II