title: The pathophysiology of acne vulgaris in children and adolescents, part 2: Tailoring treatment.
abstract: Various pathophysiologic factors are involved in the development of acne lesions, microcomedones, comedones, and inflammatory lesions. These factors include follicular hyperkeratosis, increased colonization of follicles by Propionibacterium acnes, increased sebum production, and inflammatory mediators. Optimal treatment of acne involves the use of agents that address these various underlying pathogenetic factors.
authors.affiliation: Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195, USA. bergfew@cesmtp.ccf.org
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000503:physiopathology; D000279:Administration, Cutaneous; D000287:Administration, Topical; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects* / Q000473:pathology
chemical_list: D012176:Retinoids