Association studies for finding cancer-susceptibility genetic variants.
Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the search for such genes, but success has been limited so far. Increased knowledge of the function of genes and the architecture of human genetic variation combined with new genotyping technologies herald a new era of gene mapping by association.
Pharoah
Paul D P
PD
Cancer Research UK Human Cancer Genetics Group, Department of Oncology, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK.
Dunning
Alison M
AM
Ponder
Bruce A J
BA
Easton
Douglas F
DF
D002471:Cell Transformation, Neoplastic; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D012107:Research Design