Tritium labelling of dopaminergic ligands domperidone and (+/-)-7-hydroxy DPAT.
Methods are presented for tritiating the D2 specific dopaminergic antagonist domperidone and D3 specific dopaminergic agonist (+/-)-7-hydroxy DPAT. Techniques to characterize the products of the tritiation are also given.
Pounds
Scot
S
Custom Synthesis, PerkinElmer Life and Analytical Sciences, Inc., 549 Albany St., Boston, MA 02118, USA.
Seguin
Richard J
RJ
Filer
Crist N
CN
D004294:Domperidone / Q000737:chemistry*; D065127:Dopamine D2 Receptor Antagonists; D007553:Isotope Labeling / Q000379:methods*; D008024:Ligands; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013764:Tetrahydronaphthalenes / Q000737:chemistry*; D014316:Tritium / Q000737:chemistry*
D065127:Dopamine D2 Receptor Antagonists; D008024:Ligands; D019275:Radiopharmaceuticals; D013764:Tetrahydronaphthalenes; D014316:Tritium; D004294:Domperidone; C031349:7-hydroxy-2-N,N-dipropylaminotetralin