[Hair analysis as a document of oxcarbazepine therapy in fatal levomepromazine poisoning].
A development of contemporary analytical methods makes possible to use hairs in toxicological analysis for documentation history of drug administration. An undertaken subject has been illustrated by a suicidal fatal poisoning of 58-year-old man with a neuroleptic drug--levomepromazine. Toxicological analysis carried out by HPLC/APCI/MS, besides of standardized postmortem specimen as blood, urine, liver and cerebrospinal fluid included also victim hairs. As a result of analytical procedure levomepromazine at high concentrations was revealed, which may be responsible for death. Moreover, and antiepileptic drug--oxcarbazepine and two main metabolites at therapeutic concentrations were revealed parallel. In three 2-cm segments of hair oxcarbazepine and two metabolites were detected, levomepromazine, in contrary, was not detected in this specimen. Complex chemical-toxicological investigation confirmed information that victim was an epileptic patient and was treated with oxcarbazepine at least 6 months before death while toxic dose of levomepromazine, as one could suppose, he took to commit suicide.
Kłys
Małgorzata
M
Zakład Medycyny Sadowej, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie. mpklys@cyf-kr.edu.pl
Rojek
Sebastian
S
Klementowicz
Wiesława
W
Bolechała
Filip
F
D000927:Anticonvulsants / Q000032:analysis* / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000506:poisoning*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy; D017809:Fatal Outcome; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008297:Male; D008728:Methotrimeprazine / Q000506:poisoning*; D008875:Middle Aged; D000078330:Oxcarbazepine; D013405:Suicide; D013997:Time Factors
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D002220:Carbamazepine; D008728:Methotrimeprazine; D000078330:Oxcarbazepine