title: The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice.
abstract: Phencyclidine has frequently been used to model schizophrenia in animals. In the present study, the ability of the neuronal selective nitric oxide synthase (NOS) inhibitor, Nomega-propyl-L-arginine, to block the behavioural effects of phencyclidine in mice was investigated. N(omega)-propyl-L-arginine (20 mg/kg) was found to block both phencyclidine (4 mg/kg)-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity in the mice tested. It is concluded that the NOS-sensitive behavioural effects of phencyclidine in rodents is dependent on neuronal NOS and that NO may play a role in the psychotomimetic effects of phencyclidine.
authors.affiliation: Department of Pharmacology, The Sahlgrenska Academy at Göteborg University, POB 431, SE 405 30 Göteborg, Sweden.
authors.forename: Daniel
authors.initials: D
authors.lastname: Klamer
authors.forename: Jörgen A
authors.initials: JA
authors.lastname: Engel
authors.forename: Lennart
authors.initials: L
authors.lastname: Svensson
mesh_terms: D000161:Acoustic Stimulation; D000465:Algorithms; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006213:Hallucinogens / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D010622:Phencyclidine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D013216:Reflex, Startle / Q000187:drug effects*
chemical_list: D004791:Enzyme Inhibitors; D018691:Excitatory Amino Acid Antagonists; D006213:Hallucinogens; C109116:N(omega)-propargylarginine; D009419:Nerve Tissue Proteins; D001120:Arginine; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496321:Nos1 protein, mouse; D010622:Phencyclidine