title: Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice.
abstract: Tachykinins are important in the development of pulmonary inflammation in mice but the tachykinin receptor subtype mediating this response has not been defined. To elucidate the role of tachykinin NK3-receptors on allergen-induced pulmonary inflammation, studies were performed on ovalbumin (OVA) sensitized and challenged mice with genetic disruption of the tachykinin NK3-receptor (NK3-/-). Aerosol OVA (0.5%) challenge produced eosinophil influx into the bronchoalveolar lavage fluid and lung tissue, goblet cell hyperplasia and damage to the airway epithelium of both NK3-/- mice and in wild type control mice (NK3+/+). There was no difference in the magnitude of these allergic inflammatory pulmonary responses between NK3-/- and NK3+/+ mice. These results find no role for tachykinin NK3-receptors on the pulmonary eosinophilia and lung damage after antigen challenge in mice.
authors.affiliation: Department of Allergy and Immunology, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
authors.forename: T T
authors.initials: TT
authors.lastname: Kung
authors.forename: Y
authors.initials: Y
authors.lastname: Crawley
authors.forename: H
authors.initials: H
authors.lastname: Jones
authors.forename: B
authors.initials: B
authors.lastname: Luo
authors.forename: H
authors.initials: H
authors.lastname: Gilchrest
authors.forename: S
authors.initials: S
authors.lastname: Greenfeder
authors.forename: J C
authors.initials: JC
authors.lastname: Anthes
authors.forename: S
authors.initials: S
authors.lastname: Lira
authors.forename: M
authors.initials: M
authors.lastname: Wiekowski
authors.forename: D N
authors.initials: DN
authors.lastname: Cook
authors.forename: J A
authors.initials: JA
authors.lastname: Hey
authors.forename: R W
authors.initials: RW
authors.lastname: Egan
authors.forename: R W
authors.initials: RW
authors.lastname: Chapman
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology; D005260:Female; D018836:Inflammation Mediators / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011657:Pulmonary Eosinophilia / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D018042:Receptors, Neurokinin-3 / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D012130:Respiratory Hypersensitivity / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D018836:Inflammation Mediators; D018042:Receptors, Neurokinin-3