title: L protein, the RNA-dependent RNA polymerase of hantaviruses.
abstract: L protein of hantaviruses is the RNA transcriptase and replicase that transcribes mRNAs and replicates the genomic RNA using antigenomic RNA as an intermediate. It also appears to have endonuclease activity. In this review, the current knowledge on the hantavirus L protein is presented including sequence motifs conserved in RNA polymerases, mechanisms of RNA synthesis and also the most recent findings on homologous RNA recombination and membrane association.
authors.affiliation: Department of Virology, Haartman Institute, 00014 University of Helsinki, Helsinki, Finland.
authors.forename: S K J
authors.initials: SK
authors.lastname: Kukkonen
authors.forename: A
authors.initials: A
authors.lastname: Vaheri
authors.forename: A
authors.initials: A
authors.lastname: Plyusnin
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000821:virology; D002467:Cell Nucleus / Q000821:virology; D002522:Chlorocebus aethiops; D014644:Genetic Variation; D006476:Orthohantavirus / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000096:biosynthesis; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D016415:Sequence Alignment; D014158:Transcription, Genetic; D014709:Vero Cells; D014764:Viral Proteins / Q000737:chemistry / Q000502:physiology*; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins; C500570:L protein, hantavirus; D012324:RNA-Dependent RNA Polymerase