Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?
The purpose of this study is to investigate possible influences of different stressors (saline injections, light deprivation and constant light regimen) and geroprotectors (Epitalon and melatonin) on survivals of female HER-2/neu transgenic mice. We propose a semi-parametric model of heterogeneous mortality (frailty model) for the analysis of the experimental data. In this model, we assume that treatment influences parameters of both frailty distribution and baseline hazard. The unique design of the experiments makes it possible to compare the effects on survival produced by different treatments in terms of changes in population heterogeneity and underlying hazard. Parameters of the model help to describe the possible influences of various stressors, geroprotectors, and their dosage on the life span of laboratory animals. The proposed model helps to advance our understanding of the effects--such as debilitation, longevity hormesis and incomplete hormesis--which occur in the population as a result of different treatments.
Semenchenko
Ganna V
GV
Max Planck Institute for Demographic Research, Konrad-Zuse-Strasse 1, Rostock D-18057, Germany. semenchenko@demogr.mpg.de
Anisimov
Vladimir N
VN
Yashin
Anatoli I
AI
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D018734:Genes, erbB-2; D008136:Longevity / Q000187:drug effects; D008325:Mammary Neoplasms, Experimental / Q000209:etiology / Q000517:prevention & control; D008550:Melatonin / Q000494:pharmacology; D051379:Mice; D008822:Mice, Transgenic; D009842:Oligopeptides / Q000494:pharmacology; D010775:Photic Stimulation; D012683:Sensory Deprivation; D012965:Sodium Chloride / Q000494:pharmacology; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*; D016019:Survival Analysis
D009842:Oligopeptides; D012965:Sodium Chloride; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine