title: [Non alcoholic steatohepatitis: an emergent and potentially serious pathology].
abstract: Nonalcoholic steatohepatitis is an acquired liver disease, usually metabolic characterised by histologic lesions with steatosis, intralobular necrosis and inflammatory infiltrates. Liver biopsy findings are identical to those seen in alcoholic hepatitis. Nonalcoholic steatohepatitis is increasingly reported in industrial countries because of an increase of the prevalence of obesity and diabetes which are the most common risk factors of this disease. The diagnosis of nonalcoholic steatohepatitis is based on a confrontation between clinical and anatomic data and an exclusion of an excessive intake of alcohol and other hepatic disease. Liver biopsy has a prognosis and histologic benefit especially when there is risk factors of fibrosis. This disease is potentially severe with a potential risk for progression to cirrhosis. Progress in pathogenesis is noted but no definite therapy exist. The aim of this review is to indicate current knowledge for the gravity of nonalcoholic steatohepatitis and its consequence and to understand the pathogenesis to prevent cirrhosis.
authors.affiliation: Hôpital universitaire Sahlout, Sousse Tunisie: Service de Gastro-entérologie.
authors.forename: Héla
authors.initials: H
authors.lastname: Elloumi
authors.forename: Dalenda
authors.initials: D
authors.lastname: Arfaoui
authors.forename: Mehdi
authors.initials: M
authors.lastname: Joudène
authors.forename: Badreddine
authors.initials: B
authors.lastname: Sriha
authors.forename: Muncef
authors.initials: M
authors.lastname: Korbi
authors.forename: Salem
authors.initials: S
authors.lastname: Ajmi
mesh_terms: D005234:Fatty Liver / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index