New variant of the human metapneumovirus (HMPV) associated with an acute and severe exacerbation of asthma bronchiale.
Recently, an increasing number of studies demonstrated that the human metapneumovirus (HMPV) causes mild to severe respiratory infections in children and immunosuppressed adults, and may be a frequent but somewhat undervalued pathogen. Here, we report the detection of a new variant of HMPV that is not closely related to the HMPV strains described until now. The strain was detected in a 6.5-year-old girl with an acute and severe exacerbation of asthma bronchiale triggered by an infection with a newly detected HMPV variant. The presented data provide new information on genetic heterogeneity of HMPV and necessitate an optimization of diagnostic procedures for the detection of HMPV infection.
Schildgen
Oliver
O
Institute for Medical Microbiology and Immunology, University Hospital Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. schildgen@mibi03.meb.uni-bonn.de
Geikowski
Tilman
T
Glatzel
Thomas
T
Simon
Arne
A
Wilkesmann
Anja
A
Roggendorf
Michael
M
Viazov
Sergei
S
Matz
Bertfried
B
D000208:Acute Disease; D001249:Asthma / Q000150:complications / Q000821:virology*; D002648:Child; D005260:Female; D006801:Humans; D029121:Metapneumovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D018184:Paramyxoviridae Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics
D012367:RNA, Viral