title: [Factor VIII activity in patients with central retinal vein occlusion in comparison to patients with a history of pelvic and lower limb venous thrombosis and a healthy control group].
abstract: BACKGROUND
  High factor VIII activity levels increase the risk of venous thromboembolism. This study was carried out to investigate the association between factor VIII activity and central retinal vein occlusion (CRVO) in comparison to patients with a history of venous thrombosis and a healthy control group.
  
  
  METHODS
  We examined the factor VIII activity in 62 patients with CRVO, 67 patients with venous thrombosis and 107 healthy individuals. The study measure employed for factor VIII activity was a one-stage clotting assay.
  
  
  RESULTS
  53.2 % of the patients with CRVO had an elevated factor VIII activity of more than 150 % (> 150 IU/dl). 78.5 % of the patients with venous thrombosis and 19.7 % of the healthy control group had an elevated factor VIII activity (> 150 IU/dl).
  
  
  CONCLUSIONS
  Elevated factor VIII activity is likely to have an influence on the pathogenesis of the central retinal vein occlusion.
authors.affiliation: Augenklinik, Klinikum Offenburg. frank.faude@klinikum-offenburg.de
authors.forename: F
authors.initials: F
authors.lastname: Faude
authors.forename: S
authors.initials: S
authors.lastname: Faude
authors.forename: A
authors.initials: A
authors.lastname: Siegemund
authors.forename: P
authors.initials: P
authors.lastname: Wiedemann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood* / Q000175:diagnosis*; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000097:blood* / Q000175:diagnosis*; D013924:Thrombophlebitis / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D005169:Factor VIII