title: [An experimental study on repair of laryngeal cartilage defect with the bone morphogenetic protein composite].
abstract: OBJECTIVE
  To study the effects of the bone matrix gelatin and composite of bone morphogenetic protein and fibrin glue (BMP-FG) on the repair of thyroid cartilage defect.
  
  
  METHODS
  Full-thickness defects measuring 0.4 cm x 0.4 cm were created in four sections in thyroid cartilages of 20 adult dogs. The defects were divided into 4 groups by the sections they in. Group A was empty group, without implant; Group B were repaired by implanted with hydroxylapatite; Group C with bone matrix gelatin (containing BMP); Group D with bone morphogenetic protein-fibrin glue composite. The animals were killed separately at 2, 4, 12 weeks after operation. The effects of repair were analyzed by routine histological examination and electron microscope.
  
  
  RESULTS
  In the BMP-FG implanted group, the result showed complete absorption of the implant and substitution by new-formed cartilage and bone. The defects in the BMG group regenerated less cartilage and bone, the inflammation was sever. The gross appearance and histological features of HA group were similar to the empty group.
  
  
  CONCLUSIONS
  Both BMP-FG and BMG can induce cartilage and bone regeneration to repair the defect of thyroid cartilage. BMP-FG has a better effect.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital, Kunming Medical College, Kunming 650031.
authors.forename: Chongcai
authors.initials: C
authors.lastname: Tan
authors.forename: Wenhui
authors.initials: W
authors.lastname: Wang
authors.forename: Jian fei
authors.initials: Jf
authors.lastname: Chen
authors.forename: Baoyuan
authors.initials: B
authors.lastname: Liu
authors.forename: Yuping
authors.initials: Y
authors.lastname: Na
authors.forename: Biao
authors.initials: B
authors.lastname: Yuan
authors.forename: Congjun
authors.initials: C
authors.lastname: Ye
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.forename: Peng
authors.initials: P
authors.lastname: Hu
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D016723:Bone Remodeling / Q000187:drug effects; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D008297:Male; D013957:Thyroid Cartilage / Q000293:injuries / Q000601:surgery*
chemical_list: D019485:Bone Morphogenetic Proteins; D015718:Fibrin Tissue Adhesive