The echinocandin "target" identified by cross-linking is a homolog of Pil1 and Lsp1, sphingolipid-dependent regulators of cell wall integrity signaling.
Edlind
Thomas D
TD
Katiyar
Santosh K
SK
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects / Q000502:physiology*; D003432:Cross-Linking Reagents; D054714:Echinocandins; D005656:Fungal Proteins / Q000737:chemistry / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000737:chemistry / Q000302:isolation & purification; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D010750:Phosphoproteins / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects*; D013107:Sphingolipids / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000235:genetics
D000935:Antifungal Agents; D003432:Cross-Linking Reagents; D054714:Echinocandins; D005656:Fungal Proteins; C487328:LSP1 protein, S cerevisiae; C487327:PIL1 protein, S cerevisiae; D010456:Peptides, Cyclic; D010750:Phosphoproteins; D029701:Saccharomyces cerevisiae Proteins; D013107:Sphingolipids; C007572:echinocandin B; D005964:Glucosyltransferases; C040232:glucan synthase; C051302:RHO1 protein, S cerevisiae; D020741:rho GTP-Binding Proteins