title: [Role of the hemostasis in unstable angina pectoris].
abstract: Haemostasis plays an important role in the development of cardiac complications--acute coronary syndromes. The thrombus formation in coronary arteries, related to unstable atherosclerotic plaque rupture is the basic pathogenesis of acute coronary syndromes. The balance between coagulation and fibrinolytic system influences on ruptured atherosclerotic plaque and following acute coronary syndrome. Critical narrow or total occlusion of the coronary artery could be a consequence of this interaction. Researches are continued to determine precisely role of haemostasis disorders in unstable angina pectoris. The aim of this paper is to review the literature data concerning haemostatic risk factors in unstable angina pectoris. Fibrinogen, thrombocytes, factor VIII, von Willebrand factor (vWF), thrombomodulin (TM), plasminogen activator inhibitor--type 1 (PAI-1), tissue-plasminogen activator (t-PA) and other haemostatic factors, play more or less essential role in unstable angina pectoris. However further investigations are needed to determine their utility and to search for new and better haemostatic factors of acute coronary syndromes.
authors.affiliation: Klinika Kardiochirurgii Akademii Medycznej w Białymstoku. lispiotr@poczta.onet.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Lisowski
authors.forename: Jolanta
authors.initials: J
authors.lastname: Małyszko
authors.forename: Anna
authors.initials: A
authors.lastname: Lisowska
authors.forename: Bronisław
authors.initials: B
authors.lastname: Czech
authors.forename: Michał
authors.initials: M
authors.lastname: Myśliwiec
authors.forename: Ryszard
authors.initials: R
authors.lastname: Jackowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Hirnle
mesh_terms: D000789:Angina, Unstable / Q000097:blood / Q000209:etiology*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D003328:Coronary Thrombosis / Q000097:blood / Q000150:complications*; D005169:Factor VIII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D012307:Risk Factors; D018180:Thrombomodulin / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin; D014841:von Willebrand Factor; D005169:Factor VIII; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator