title: Synthesis of pathogen inactivating nucleic acid intercalators.
abstract: A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by several logarithmic decades.
authors.affiliation: Institut für Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Strasse 2, 06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de
authors.forename: René
authors.initials: R
authors.lastname: Csuk
authors.forename: Alexander
authors.initials: A
authors.lastname: Barthel
authors.forename: Thorsten
authors.initials: T
authors.lastname: Brezesinski
authors.forename: Christian
authors.initials: C
authors.lastname: Raschke
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism; D004492:Edetic Acid / Q000737:chemistry; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007501:Iron / Q000378:metabolism; D017909:Levivirus / Q000187:drug effects*; D009696:Nucleic Acids / Q000187:drug effects*
chemical_list: D000166:Acridines; D000998:Antiviral Agents; D007364:Intercalating Agents; D009696:Nucleic Acids; D004492:Edetic Acid; D007501:Iron; D001205:Ascorbic Acid