title: Development of implant tablet for a week-long sustained release.
abstract: An implant tablet for a week-long sustained release was developed by the direct compression method using poly-DL-lactic acid (PLA) and poly(DL-lactic acid-co-glycolic acid) copolymer (PLGA) as a matrix and phenol red (PR) as a model drug. The in vitro release was affected by formulations, especially by drug content and polymer species. The release rate correlated with the rate of absorption of water. The implant tablet (30 mg) containing 1 mg of PR, prepared using PLGA (MW 10,000; lactic acid/glycolic acid=1:1, mol/mol) by compression at 50 kg/cm(2) for 10 s, was found to efficiently exhibit a week-long sustained release in vitro, and applied in vivo. The remaining amount or plasma concentration of PR after s.c. administration of the implant tablet to rats demonstrated that the implant tablet showed a week-long sustained release in vivo. The present implant tablet is suggested to be useful as a drug delivery system for supplying drugs for approximately 1 week.
authors.affiliation: Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Takahashi
authors.forename: Hiraku
authors.initials: H
authors.lastname: Onishi
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Machida
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D004343:Drug Implants; D066298:In Vitro Techniques; D019344:Lactic Acid / Q000008:administration & dosage; D008297:Male; D010637:Phenolsulfonphthalein / Q000008:administration & dosage; D011100:Polyglycolic Acid / Q000008:administration & dosage; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D004343:Drug Implants; D011108:Polymers; D013607:Tablets; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D010637:Phenolsulfonphthalein