Chiral mixed ligand Co(II) and Ni(II) complexes: synthesis and biological activity.
Chiral mixed ligand (CML) transition metal complexes of the type MQL.2H2O, where M is Co(II)/Ni(II), Q is deprotonated 8-hydroxyquinoline and L is a deprotonated chiral saccharide such as (+)-glucose and (-)-fructose, have been synthesized. The metal complexes have been characterized on the basis of elemental analysis and various physicochemical techniques such as molar conductance, specific rotation measurements, magnetic, spectral and thermal studies. The cup-plate method has been used to study the antibacterial activity of the compounds against some of the pathogenic bacteria such as C. diphtheriae, E. coli, S. typhi, S. dysenteriae, S. aureus and V. cholerae. The antifungal activity of the complexes against some of the pathogenic fungi such as Candida albicans and Aspergillus niger has been studied by the tube dilution method. The results have been compared against those of controls, which were screened simultaneously. The complexes have been screened for acute oral toxicity in albino rats. The method of Litchfield and Wilcoxon has been used to determine the LD50 values.
Shivankar
Vitthal S
VS
Department of Chemistry, Mahatma Phule A. S. C. College, Panvel, Dist. Raigad (Maharashtra) 410 206, India.
Thakkar
Narendra V
NV
D000818:Animals; D003035:Cobalt / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D008024:Ligands; D008297:Male; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D009532:Nickel / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism
D008024:Ligands; D003035:Cobalt; D009532:Nickel