title: Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp.
abstract: A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class A carbapenem-hydrolyzing enzyme, KPC-2 beta-lactamase, was isolated from a patient with sepsis at a Boston hospital. This is the first report of the production of a plasmid-encoded KPC-2 beta-lactamase by an Enterobacter sp.
authors.affiliation: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.
authors.forename: Ashfaque
authors.initials: A
authors.lastname: Hossain
authors.forename: M J
authors.initials: MJ
authors.lastname: Ferraro
authors.forename: R M
authors.initials: RM
authors.lastname: Pino
authors.forename: R B
authors.initials: RB
authors.lastname: Dew
authors.forename: E S
authors.initials: ES
authors.lastname: Moland
authors.forename: T J
authors.initials: TJ
authors.lastname: Lockhart
authors.forename: K S
authors.initials: KS
authors.lastname: Thomson
authors.forename: R V
authors.initials: RV
authors.lastname: Goering
authors.forename: N D
authors.initials: ND
authors.lastname: Hanson
mesh_terms: D015780:Carbapenems / Q000378:metabolism*; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004754:Enterobacter / Q000201:enzymology* / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D010957:Plasmids / Q000235:genetics*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D015780:Carbapenems; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases