[Immunohistochemical study of benign lymphoadenosis of oral mucosa].
OBJECTIVE
To study the expression of Ki-67 and the changes of MVD and apoptosis in benign lymphoadenosis of oral mucosa (BLOM).


METHODS
The expression of Ki-67, CD34 and apoptosis were evaluated by SP immunohistochemical staining in 15 BLOM, 9 BLOM with dysplasia, 15 oral squamous cell carcinoma (OSCC).


RESULTS
The expression of Ki-67 in BOLM with dysplasia and OSCC was significantly higher than that of BLOM without dysplasia and normal oral mucosa (P < 0.05). The MVD in all BLOM and OSCC was significantly higher than that in normal mucosa (P < 0.05). Apoptosis in BLOM was higher than in normal mucosa and OSCC (P < 0.05).


CONCLUSIONS
The expression of Ki-67 and MVD in BLOM with dysplasia were between normal oral mucosa and oral carcinoma. The occurrence of apoptosis in BLOM was significantly higher than in normal oral mucosa. The results suggest that BLOM had the potentiality of malignant transformation.
Li
Shu-xia
SX
Department of Oral Pathology, Peking University School of Stomatology, Beijing 100081, China. lishuxia@sina.com
Yu
Shi-feng
SF
Sun
Kai-hua
KH
D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008232:Lymphoproliferative Disorders / Q000378:metabolism / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology*
D019394:Ki-67 Antigen