title: Comparison of simultaneous splenic sample PCR with blood sample PCR for diagnosis and treatment of experimental Ehrlichia canis infection.
abstract: This report presents evidence that dogs recover from acute canine monocytic ehrlichiosis (CME) after 16 days of doxycycline treatment (10 mg/kg of body weight every 24 h). Blood PCR was as valuable as splenic aspirate PCR for early diagnosis of acute CME. Splenic aspirate PCR was, however, superior to blood PCR for the evaluation of ehrlichial elimination.
authors.affiliation: School of Veterinary Medicine, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel. harrus@agri.huji.ac.il
authors.forename: Shimon
authors.initials: S
authors.lastname: Harrus
authors.forename: Martin
authors.initials: M
authors.lastname: Kenny
authors.forename: Limor
authors.initials: L
authors.lastname: Miara
authors.forename: Itzhak
authors.initials: I
authors.lastname: Aizenberg
authors.forename: Trevor
authors.initials: T
authors.lastname: Waner
authors.forename: Susan
authors.initials: S
authors.lastname: Shaw
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D004318:Doxycycline / Q000627:therapeutic use; D041061:Ehrlichia canis; D016873:Ehrlichiosis / Q000175:diagnosis / Q000188:drug therapy* / Q000662:veterinary*; D010976:Platelet Count; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods*; D013154:Spleen / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004318:Doxycycline