Is it time for medical therapy for aortic valve disease?
Calcific aortic stenosis is the most common indication for surgical valve replacement. Currently there are no medical therapies approved for the treatment of this disease. This review will summarize the clinical and experimental studies published over the past 5 years that indicate that medical therapy may be an option for this patient population.
Rajamannan
Nalini M
NM
Northwestern University Feinberg School of Medicine, Feinberg Cardiovascular Research Institute, 303 E Chicago Avenue, Tarry 12-703, Chicago, IL 60611, USA. n-rajamannan@northwestern.edu.
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001024:Aortic Valve Stenosis / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D000069059:Atorvastatin; D001707:Biopsy, Needle; D002114:Calcinosis / Q000473:pathology* / Q000601:surgery; D018849:Controlled Clinical Trials as Topic; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011379:Prognosis; D011758:Pyrroles / Q000627:therapeutic use*; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome
D006538:Heptanoic Acids; D000960:Hypolipidemic Agents; D011758:Pyrroles; D000069059:Atorvastatin