Alternative splicing of interleukin-6 mRNA in mice.
Expression of mRNA for interleukin-6, interleukin-6Delta3, and interleukin-6Delta5 was detected in placental tissue (second and third trimesters of pregnancy) and spleen of mice immunized with sheep erythrocytes in high dose. We hypothesize that translation of mRNA yields proteins capable of binding to individual subunits of the interleukin-6 receptor and possessing effector functions.
Yatsenko
O P
OP
Laboratory for Regulation of Immunopoiesis, Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences.
Filipenko
M L
ML
Khrapov
E A
EA
Voronina
E N
EN
Sennikov
S V
SV
Kozlov
V A
VA
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000276:immunology; D005091:Exons; D005260:Female; D015850:Interleukin-6 / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D014176:Protein Biosynthesis; D020033:Protein Isoforms / Q000737:chemistry; D017433:Protein Structure, Secondary; D012333:RNA, Messenger / Q000378:metabolism; D017384:Sequence Deletion; D017386:Sequence Homology, Amino Acid; D012756:Sheep; D013154:Spleen / Q000378:metabolism
D015850:Interleukin-6; D020033:Protein Isoforms; D012333:RNA, Messenger