BINOL catalyzed enantioselective addition of titanium phenylacetylide to aromatic ketones.
An enantioselective addition of titanium phenylacetylide to ketones, promoted by BINOL, is described; this new enantioselective protocol gives high enantiomeric excess (up to 90% ee) with aromatic ketones using a simple procedure without pyrophoric or expensive reagents.
Cozzi
Pier Giorgio
PG
Dipartimento di Chimica G. Ciamician, Via Selmi 2, 40126, Bologna, Italy. piergiorgio.cozzi@unibo.it
Alesi
Silvia
S
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D000480:Alkynes; C406944:BINOL, naphthol; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D009284:Naphthols; D009942:Organometallic Compounds; D014025:Titanium