title: Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation.
abstract: The pathway leading to cell death in clinical liver transplantation is not known. Eight liver transplant recipients and eight donors were enrolled in this study. Postoperative serum levels of alanine transferase had significantly increased in the recipients compared with those in the donors. Mild centri-lobular necrosis was observed in only liver tissues taken from the recipients. Tumor necrosis factor (TNF)-R1 and death receptor 5 expression levels had increased in liver tissues taken from the recipients. There were no changes in the levels of Fas/Fas ligand expression in liver tissues from either the donors or recipients. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression was down-regulated in donor liver after hepatectomy and liver allograft after implantation. The results suggest that, although ischemic liver injury was not serious, due to the short ischemia time, TNF and TRAIL signals are associated with liver ischemic injury in live-donor liver transplantation but Fas signal is not.
authors.affiliation: Second Department of Surgery, Faculty of Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551 Hiroshima, Japan. htashiro@hiroshima-u.ac.jp
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tashiro
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Itamoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohdan
authors.forename: Kouji
authors.initials: K
authors.lastname: Arihiro
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tateaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakahara
authors.forename: Makoto
authors.initials: M
authors.lastname: Ochi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hino
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Mizunuma
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Hara
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tokita
authors.forename: Takashi
authors.initials: T
authors.lastname: Onoe
authors.forename: Kouhei
authors.initials: K
authors.lastname: Ishiyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsuta
authors.forename: Keizou
authors.initials: K
authors.lastname: Sugino
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Asahara
mesh_terms: D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002675:Child, Preschool; D002763:Cholecystectomy; D053222:Fas Ligand Protein; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007511:Ischemia / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D009336:Necrosis; D011184:Postoperative Period; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor; D053221:TNF-Related Apoptosis-Inducing Ligand; C505639:TNFRSF10B protein, human; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor