title: Maternal plasma concentrations of insulinlike growth factor-1 and insulinlike growth factor-binding protein-1 in early pregnancy and subsequent risk of preeclampsia.
abstract: OBJECTIVE
  We investigated the relationship between maternal plasma free insulinlike growth factor-1 (IGF-1) and insulinlike growth factor-binding protein-1 (IGFBP-1) concentrations and risk of preeclampsia.
  
  
  METHODS
  Maternal blood samples were collected at 13 weeks' gestation on average. From the cohort, we selected 53 women who developed preeclampsia and 477 who remained normotensive. Free IGF-1 and IGFBP-1 concentrations were measured using immunoassays. Logistic regression procedures were used to calculate odds ratios (OR) and 95% confidence intervals (95% CI).
  
  
  RESULTS
  Women who developed preeclampsia had 18% and 27% lower concentrations of free IGF-1 and IGFBP-1, respectively, than controls (P < 0.05). There was a 57% reduced risk of preeclampsia among women with free IGF-1 concentrations of >or= 0.81 ng/mL (OR = 0.43, 95% CI 0.23-0.83) and a 43% reduced risk among women with IGFBP-1 concentrations of >or= 72.36 ng/mL (OR = 0.53, 95% CI 0.23-1.21).
  
  
  CONCLUSIONS
  Alterations of free IGF-1 and IGFBP-1 concentrations in maternal plasma during early pregnancy are associated with risk of preeclampsia. These associations may help to further elucidate the pathologic processes of preeclampsia.
authors.affiliation: Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ning
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Williams
authors.forename: Surab
authors.initials: S
authors.lastname: Vadachkoria
authors.forename: Martin
authors.initials: M
authors.lastname: Muy-Rivera
authors.forename: Ihunnaya O
authors.initials: IO
authors.lastname: Frederick
authors.forename: David A
authors.initials: DA
authors.lastname: Luthy
mesh_terms: D015331:Cohort Studies; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood* / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood* / Q000378:metabolism; D011261:Pregnancy Trimester, First / Q000378:metabolism; D012307:Risk Factors
chemical_list: C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D011257:Pregnancy Proteins; D007334:Insulin-Like Growth Factor I