The localization of Fos B, a member of transcription factor AP-1 family, in rat odontoblasts and pulpal undifferentiated ectomesenchymal cells.
It has been proposed that cellular proliferation and differentiation are accomplished by AP-1 components but different components can be responsible for different functions. The aim of this study was to compare the localization of Fos B, which is a component of AP-1, in postmitotic differentiated and undifferentiated cells via Fos B immunoreactivity. For this purpose, maxillary incisor teeth from 10 Wistar rats were obtained and Fos-B was investigated immunohistochemically in formalin-fixed, paraffin-embedded tooth sections containing odontoblasts, which are postmitotic differentiated cells, and pulpal undifferentiated ectomesenchymal cells. No significant differences in percentage of Fos B-positive cells were observed between the two cell types (p>0.05). These findings suggest that Fos B, a component of AP-1 family, seems to have a negligible effect on differentiation and proliferation in odontoblasts and pulpal undifferentiated ectomesenchymal cells.
Keklikoglu
Nurullah
N
Department of Histology and Embryology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey. nkeklik@istanbul.edu.tr
D000818:Animals; D003782:Dental Pulp / Q000737:chemistry* / Q000166:cytology; D059630:Mesenchymal Stem Cells / Q000737:chemistry*; D009804:Odontoblasts / Q000737:chemistry* / Q000166:cytology; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D051381:Rats; D018808:Transcription Factor AP-1 / Q000032:analysis* / Q000145:classification
D016760:Proto-Oncogene Proteins c-fos; D018808:Transcription Factor AP-1