title: Cuprous oxidase activity of CueO from Escherichia coli.
abstract: We have found CueO from Escherichia coli to have a robust cuprous oxidase activity, severalfold higher than any homologue. These data suggest that a functional role for CueO in protecting against copper toxicity in vivo includes the removal of Cu(I).
authors.affiliation: Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Satish K
authors.initials: SK
authors.lastname: Singh
authors.forename: Gregor
authors.initials: G
authors.lastname: Grass
authors.forename: Christopher
authors.initials: C
authors.lastname: Rensing
authors.forename: William R
authors.initials: WR
authors.lastname: Montfort
mesh_terms: D003300:Copper / Q000378:metabolism / Q000633:toxicity*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D003300:Copper; D010088:Oxidoreductases; C499679:cueO protein, E coli; C024748:copper oxidase