title: [Systemic corticoid application in combination with topical mitomycin or dexamethasone. Inhibition of wound healing after tympanic membrane perforation].
abstract: BACKGROUND
  The purpose of this study was to determine whether systemic glucocorticoid application, in combination with topical mitomycin or dexamethasone, prolongs the patency of a tympanic membrane perforation.
  
  
  METHODS
  Bilateral myringotomies were performed on 24 rats. The 48 ears were separated into eight groups. Treatment with combined systemic and topical dexamethasone or mitomycin differed between these groups. After the first 2 weeks, the animals were checked weekly for a total of 12 weeks.
  
  
  RESULTS
  A combination of systemic and topical dexamethasone delayed tympanic membrane closure after myringotomy. Perforation size increased in all tympanic membranes treated with mitomycin plus systemic dexamethasone.
  
  
  CONCLUSIONS
  Topical mitomycin plus systemic glucocorticoid may lead to a massive malfunction of tympanic membrane healing.
authors.affiliation: Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, Kopf- und Hals-Chirurgie der Ernst-Moritz-Arndt-Universität Greifswald. H.Kaftan@web.de
authors.forename: H
authors.initials: H
authors.lastname: Kaftan
authors.forename: W
authors.initials: W
authors.lastname: Hosemann
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D007275:Injections, Intravenous; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000187:drug effects*; D018058:Tympanic Membrane Perforation / Q000188:drug therapy / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D016685:Mitomycin; D003907:Dexamethasone