Metabolic acidosis due to topiramate.
(1) Topiramate carries a dose-dependent risk of severe metabolic acidosis in adults and children. (2) Various situations increase the risk, including diarrhea, respiratory disorders and surgery. (3) Loss of appetite, fatigue and hyperventilation are warning signs.
D000138:Acidosis / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000097:blood; D001639:Bicarbonates / Q000097:blood; D002648:Child; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States; D014486:United States Food and Drug Administration
D000927:Anticonvulsants; D001639:Bicarbonates; D005632:Fructose