Coordinating cytoskeletal tracks to polarize cellular movements.
For many years after the discovery of actin filaments and microtubules, it was widely assumed that their polymerization, organization, and functions were largely distinct. However, in recent years it has become increasingly apparent that coordinated interactions between microtubules and filamentous actin are involved in many polarized processes, including cell shape, mitotic spindle orientation, motility, growth cone guidance, and wound healing. In the past few years, significant strides have been made in unraveling the intricacies that govern these intertwined cytoskeletal rearrangements.
Kodama
Atsuko
A
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.
Lechler
Terry
T
Fuchs
Elaine
E
D000199:Actins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000737:chemistry; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure*; D008938:Mitosis; D008954:Models, Biological; D008941:Spindle Apparatus; D014945:Wound Healing
D000199:Actins; D020558:GTP Phosphohydrolases