Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem.
We determined the in vitro activities of tigecycline and imipenem against 49 isolates of Acinetobacter baumannii, including those resistant to imipenem. The MIC at which 50% of the isolates were inhibited (MIC(50)) and the MIC(90) for tigecycline and imipenem were 2 and 2 mg/liter and 32 and 128 mg/liter, respectively, with 92 and 20%, respectively, of the strains being susceptible. Tigecycline did not show bactericidal activity in the time-kill studies (n = 9 strains). Imipenem showed bactericidal activity against seven out of nine strains. These in vitro results show that tigecycline has good in vitro bacteriostatic activity against A. baumannii, including strains resistant to imipenem.
Pachón-Ibáñez
María Eugenia
ME
Servicio de Enfermedades Infecciosas, Hospitales Universitarios Virgen del Rocío, Avda. Manuel Siurot s/n, 41013 Seville, Spain. menia@telefonica.net
Jiménez-Mejías
Manuel Enrique
ME
Pichardo
Cristina
C
Llanos
Ana Cristina
AC
Pachón
Jerónimo
J
D040981:Acinetobacter baumannii / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000078304:Tigecycline
D000078304:Tigecycline; D015378:Imipenem; D008911:Minocycline