Mechanisms of action of GH.
The process of growth, which is common to all multicellular organisms, is complex and involves the interaction of a multiplicity of factors; despite this, the GH/IGF function still maintains its preminence, and, in turn, the same is true for all approaches aimed at reducing the consequences of GH/IGF excess. In this review paper, we will deal briefly with some aspects of GH/IGF mechanism of action which are instrumental to the appreciation of a novel class of a "designer" GH antagonist, for use in conditions characterized by excess GH action and elevated serum IGF-I.
Müller
E E
EE
Department of Medical Pharmacology, Faculty of Medicine, University of Milan, Milan, Italy. eugenio.muller@unimi.it
Rigamonti
A E
AE
Cella
S G
SG
D000818:Animals; D019382:Human Growth Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism; D011986:Receptors, Somatotropin / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013002:Somatomedins / Q000378:metabolism / Q000502:physiology*
D018969:Insulin-Like Growth Factor Binding Proteins; D011986:Receptors, Somatotropin; D013002:Somatomedins; D019382:Human Growth Hormone