title: Sequential coupling of zincated hydrazone, alkenylboronate, and electrophile that creates several contiguous stereogenic centers.
abstract: A zincated N,N-dimethylhydrazone of a ketone undergoes stereospecific syn addition to E- or Z-alkenylboronate to generate a gamma-Zn/B dimetallic intermediate, which reacts with a carbon electrophile to give a gamma-borylhydrazone in good yield with excellent diastereoselectivity, creating two to four contiguous stereogenic centers in a one-pot reaction.
authors.affiliation: Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. masaharu@chem.s.u-tokyo.ac.jp
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Takuji
authors.initials: T
authors.lastname: Hatakeyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Hara
authors.forename: Hiroki
authors.initials: H
authors.lastname: Fukudome
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakamura