Benzo[alpyrene induction of cytochrome P450 1A1/1A2 in the lymph nodes of rats.
Studies of mesenteric lymph nodes of rats by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A/1A2 after oral dose of benzo[a]pyrene showed the presence of these cytochrome forms in monocytes, macrophages, reticular and litoral cells, cell detritus, and liquid contents of the paracortical zone and medullary substance sinuses. Oxidation of various exo- and endogenous toxins in the lymph nodes was revealed.
Borodin
Yu I
YI
Institute of Clinical and Experimental Lymphology, Novosibirsk. imai@mail.ru
Safina
A F
AF
Maiborodin
I V
IV
Grishanova
A Yu
AY
D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism; D001564:Benzo(a)pyrene / Q000378:metabolism*; D019363:Cytochrome P-450 CYP1A1 / Q000096:biosynthesis* / Q000378:metabolism; D019388:Cytochrome P-450 CYP1A2 / Q000096:biosynthesis* / Q000378:metabolism; D004790:Enzyme Induction; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000096:biosynthesis* / Q000378:metabolism; D008198:Lymph Nodes / Q000201:enzymology*; D017737:Macrophages, Peritoneal / Q000201:enzymology; D008297:Male; D009000:Monocytes / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar
D000911:Antibodies, Monoclonal; D007527:Isoenzymes; D001564:Benzo(a)pyrene; D019363:Cytochrome P-450 CYP1A1; D019388:Cytochrome P-450 CYP1A2