The first tandem double palladium-catalyzed aminations: synthesis of dipyrido[1,2-a:3',2'-d]imidazole and its benzo- and aza-analogues.
A new strategy for the synthesis of the title compounds via a regio- and chemoselective one-pot inter- and intramolecular Buchwald-Hartwig amination of 2-chloro-3-iodopyridine with aminoazines and -diazines is reported.
Loones
Kristof T J
KT
Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B-2020, Antwerp, Belgium.
Maes
Bert U W
BU
Dommisse
Roger A
RA
Lemière
Guy L F
GL
D000578:Amidines / Q000737:chemistry; D000586:Amination; D001372:Aza Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis*
D000578:Amidines; D001372:Aza Compounds; D007093:Imidazoles; D009942:Organometallic Compounds; D011725:Pyridines; C506107:dipyrido(1,2-a-3',2'-d)imidazole; D010165:Palladium