Urinary fluorine-18 fluorodeoxyglucose excretion with and without intravenous application of furosemide.
METHODS
Twenty patients suffering from malignancy received furosemide, twenty patients were examined by FDG-PET without diuretics. Urine volume and radioactivity were measured before and after acquisition. Bladder activity was evaluated qualitatively and quantitatively.


RESULTS
Radioactivity in the bladder was lower and the image quality higher in the furosemide group. SUV values showed a median of 3.0 in the furosemide and 6.0 in the control group. With furosemide, a larger excreted volume was seen compared to the control group. The furosemide group showed a significantly higher ratio of excreted/ injected radioactivity early after injection. However, the totally excreted radioactivity was not significantly different (p = 0.93).


CONCLUSIONS
Diuretics cause a higher urine volume with a diluted FDG concentration leading to an improved image quality. Furosemide accelerates early renal FDG elimination, reducing radiation exposure.
Diehl
Michaela
M
Department of Nuclear Medicine, University of Frankfurt, Frankfurt am Main, Germany. M.Diehl@em.uni-Frankfurt.de
Manolopoulou
Maria
M
Risse
Jörn
J
Kranert
Tilman
T
Menzel
Christian
C
Döbert
Natascha
N
Grünwald
Frank
F
D004232:Diuretics / Q000652:urine; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000652:urine*; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007275:Injections, Intravenous; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000652:urine; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000652:urine
D004232:Diuretics; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005665:Furosemide