title: T-cell post-transplantation lymphoproliferative disorders after cardiac transplantation: a single institutional experience.
abstract: Post-transplantation lymphoproliferative disorders (PTLDs) are a well-recognized and potentially life-threatening complication of solid organ transplantation. While the vast majority of PTLDs are B-cell lymphoproliferations, T-cell PTLDs are rarely seen. Among 898 patients receiving cardiac transplants between 1990 and 2003, 34 patients (3.8%) developed PTLDs with two (0.2%) T-cell PTLDs, 31 (3.5%) B-cell PTLDs and one (0.1%) natural killer cell PTLD. An additional three cases of T-cell PTLD were identified among all cardiac transplant patients followed at our institution. These T-cell PTLDs comprised a heterogeneous group of Epstein-Barr virus negative lymphoproliferations that developed late after transplantation and followed an aggressive course.
authors.affiliation: Department of Pathology, Columbia University, New York, NY, USA.
authors.forename: H Y
authors.initials: HY
authors.lastname: Draoua
authors.forename: Lawrence
authors.initials: L
authors.lastname: Tsao
authors.forename: Donna M
authors.initials: DM
authors.lastname: Mancini
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Addonizio
authors.forename: Govind
authors.initials: G
authors.lastname: Bhagat
authors.forename: Bachir
authors.initials: B
authors.lastname: Alobeid
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006084:Graft Rejection; D006331:Heart Diseases / Q000601:surgery; D016027:Heart Transplantation / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016399:Lymphoma, T-Cell / Q000209:etiology*; D008297:Male; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents