[A case of transitional cell carcinoma of the renal pelvis with adenocarcinoma producing CEA and CA19-9].
We report a case of invasive renal pelvic tumor with high serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9). An 86-year-old man presented with macrohematuria. Retrograde pyelography demonstrated a filling defect in right upper calyx, suspected of renal pelvic tumor. The levels of serum CEA and CA 19-9 were elevated to 28.0 ng/ml and 122 U/ml, respectively. No abnormalities were found in the gastrointestinal tract. Right nephroureterectomy was performed, and histopathological diagnosis was transitional cell carcinoma, grade 2>grade 3, accompanied with adenocarcinoma immuno-stained for CEA and CA19-9. A part of the tumor showed a tubular growth pattern. Both serum levels of CEA and CA 19-9 immediately decreased to the normal range after the operation, but increased again with lung and hepatic metastases.
Matsuoka
Yoh
Y
Department of Urology, Tokyo Metropolitan Tama Geriatric Hospital.
Ishimaru
Hisashi
H
Arai
Gaku
G
Aida
Junko
J
Okada
Yume
Y
Ito
Yuji
Y
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D018395:CA-19-9 Antigen / Q000096:biosynthesis* / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis* / Q000097:blood; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D007682:Kidney Pelvis; D008297:Male; D009378:Neoplasms, Multiple Primary; D009392:Nephrectomy; D014513:Ureter / Q000601:surgery
D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen