Programmed -1 ribosomal frameshifting in the SARS coronavirus.
Programmed -1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed -1 ribosomal frameshifting in this virus.
Dos Ramos
F
F
Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Box 157, Cambridge CB2 2QQ, UK. fjd24@cam.ac.uk
Carrasco
M
M
Doyle
T
T
Brierley
I
I
D000595:Amino Acid Sequence; D001483:Base Sequence; D016368:Frameshift Mutation / Q000235:genetics*; D016679:Genome, Viral; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D016366:Open Reading Frames / Q000235:genetics; D012270:Ribosomes / Q000235:genetics*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics