Topical application of nerve growth factor in human diabetic foot ulcers. A study of three cases.
Three diabetic patients with leg or foot ulcers unresponsive to conventional therapies were treated with topical application of Nerve Growth Factor (NGF). The results showed that NGF promotes healing after 5-14 weeks of treatment. This study suggests that the use of topical application of NGF may represent a new useful tool for the management of difficult diabetic ulcers.
Generini
S
S
Department of Medicine, Section of Rheumatology, University of Florence, Italy.
Tuveri
M A
MA
Matucci Cerinic
M
M
Mastinu
F
F
Manni
L
L
Aloe
L
L
D000287:Administration, Topical; D000368:Aged; D017719:Diabetic Foot / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
D020932:Nerve Growth Factor