title: Cytogenetic abnormalities in serous papillary adenocarcinoma of the ovary.
abstract: OBJECTIVE
  Epithelial ovarian tumors are usually mucinous or serous type, affecting nearly 1% of women during their lifetime. They may be regarded as benign, borderline or invasive according to pathological examination. Karyotypes of the tumor provide critical information about both the genetic predisposition and the stage of the tumor. We aimed to investigate the correlation between karyotype findings and the stage of the serous papillary tumors of the ovary.
  
  
  METHODS
  Tissue cultures were set up from 15 serous papillary adenocarcinoma samples of different stages and examined cytogenetically.
  
  
  RESULTS
  The most common chromosome abnormalities included both numerical and structural abnormalities of chromosomes 1, 3,6,7,8, 11, 21, 22 and X.
  
  
  CONCLUSIONS
  Karyotypes became more complex, as expected, with the later stages.
authors.affiliation: Obstetrics and Gynecology Clinic, Ankara Numune Education and Research Hospital, Ankara (Turkey).
authors.forename: I
authors.initials: I
authors.lastname: Sahin
authors.forename: Z
authors.initials: Z
authors.lastname: Yilmaz
authors.forename: F I
authors.initials: FI
authors.lastname: Sahin
mesh_terms: D002869:Chromosome Aberrations; D018283:Cystadenocarcinoma, Papillary / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics*