title: Hypertrophic lichen planus-like reactions combined with infundibulocystic hyperplasia: pathway to neoplasia.
abstract: BACKGROUND
  Retinoids have the capacity to accelerate the involution of multiple keratoacanthomas, including unusual variants such as keratoacanthoma marginatum centrifugum and keratoacanthoma en plaque that may persist and be associated with progressive growth and provide difficulties in diagnosis and management.
  
  
  METHODS
  We describe 3 patients who had unusual infiltrated and keratotic plaques affecting the lower legs or nasolabial area that persisted or recurred that may be related to this group of unusual keratoacanthomas. The 3 patients had differing clinical lesions that did not resemble classic keratoacanthomas, but were linked by their biopsy findings of hypertrophic lichen planus-like reaction and pseudoepitheliomatous hyperplasia with a prominent infundibulocystic component that progressed to multiple keratoacanthomas or infundibulocystic squamous cell carcinoma. Polymerase chain reaction analysis of biopsy material from 2 patients failed to detect human papillomavirus. All 3 presentations provided a therapeutic dilemma, but responded rapidly to acitretin treatment at a dosage of 10 to 25 mg daily, which was continued for 15 to 24 months.
  
  
  CONCLUSIONS
  These cases illustrate an unusual reaction pattern that is hypertrophic lichen planus-like but, instead of evolving to classic lichen planus, progresses to infundibulocystic hyperplasia and the development of multiple keratoacanthomas or infundibulocystic squamous cell carcinomas. Retinoids represent a therapeutic option for this difficult clinical problem and may obviate repeated and extensive surgery.
authors.affiliation: Skin & Cancer Foundation Australia, New South Wales 2010, Australia. skossard@scfa.edu.au
authors.forename: Steven
authors.initials: S
authors.lastname: Kossard
authors.forename: Carol
authors.initials: C
authors.lastname: Thompson
authors.forename: Gary M
authors.initials: GM
authors.lastname: Duncan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007636:Keratoacanthoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008010:Lichen Planus / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D035002:Lower Extremity; D008297:Male; D009666:Nose; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology