title: [Haemolytic disease of the newborn--from a mother with anti-Kell, anti-E and anti-Vel anti-erythrocyte alloantibodies].
abstract: A grave form of HDN (haemolytic disease of the new-born) is described in female twins, caused by Kell, E and Vel isoimmunisation. The weakly vital and anaemic new-born babies were hospitalised with signs of respiratory distress on the first day of their life after the delivery by Caesarean section in the 38 (th) week of pregnancy in the General Hospital Dubrovnik. Already during the first hours of their life jaundice developed with a high bilirubin level for their age. The direct Coombs' test on the twins and the indirect Coombs' test on the mother were positive. Immuno-haematological analysis proved the presence of anti-Kell, anti-E and the very rare anti-Vel antibodies in the mother's serum and in the plasma of both twins. We had no possibility to obtain appropriate blood for the indicated exsanguine transfusion because cross-probes with the accessible blood samples were positive. Up to the fourteenth day of life the anaemia deepened and was aggravated in one twin, the Kell positive one (phenotype CcDEe,Kk) in relation to the other, the Kell negative (phenotype CcDEe,kk) twin. The recovery of the female twins started on the 15 (th) day of life, after the transfusion of blood (phenotype: 0,ccddee, Vel negative, Kel negative), received from the bank of rare blood groups in London. This is the first described case of haemolytic disease of the new-born caused by antibodies on the antigen Kell, E and Vel. The low frequency of immunisation with rare antigens such as Kell, E and Vel, does not exclude the possibility of the occurrence of grave forms of haemolytic disease. All pregnant women with a positive indirect Coombs' test should be further immuno-haematologically tested in order to identify the antibodies type so that the treatment of the new-borns could be commenced in time.
authors.affiliation: Abteilung für Neonatologie der Klinik für Frauenheilkunde und Geburtshilfe, Universität Split, Croatia. mirjana.vucinovic@hi.hinet.hr
authors.forename: M
authors.initials: M
authors.lastname: Vućinović
authors.forename: H
authors.initials: H
authors.lastname: Jadrić
authors.forename: D
authors.initials: D
authors.lastname: Karelović
authors.forename: D
authors.initials: D
authors.lastname: Roje
authors.forename: Z
authors.initials: Z
authors.lastname: Haspl-Hundrić
authors.forename: Z
authors.initials: Z
authors.lastname: Hrgović
authors.forename: Z
authors.initials: Z
authors.lastname: Vućinović
mesh_terms: D001803:Blood Transfusion / Q000379:methods; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood* / Q000276:immunology; D007626:Kell Blood-Group System / Q000276:immunology; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D014427:Twins / Q000097:blood* / Q000276:immunology*
chemical_list: D007518:Isoantibodies; D007626:Kell Blood-Group System; D012204:Rh-Hr Blood-Group System