title: The effect of bisphenol A and chlorinated derivatives of bisphenol A on the level of serum vitellogenin in Japanese medaka (Oryzias latipes).
abstract: 2,2-bis (4-hydroxyphenyl) propane or Bisphenol A (BPA), has been reported to behave as an endocrine disrupter below acute toxic levels, and is widely present in the water environment. Although BPA is easily chlorinated, very little is reported on the effect of chlorinated BPA to the aquatic organisms. In this study, the estrogenic activities of BPA and its chlorinated derivatives were evaluated by the induction of vitellogenin (VTG) in the serum of mature male Japanese medaka. In addition, the effect of sodium hypochlorite on the decomposition of BPA was tested. The relative potencies of estrogenic activities of chlorinated BPA descended in the order 3,3'-diCIBPA>BPA> or =3-CIBPA>3,3',5-triCIBPA, and no estrogenic activity was observed in 3,3',5,5'-tetraCIBPA. Lowest Observed Effect Concentration (LOEC) and No Observed Effect Concentration (NOEC) for both 3-CIBPA and 3,3'-diCIBPA were 500 microg/L and 200 microg/L, respectively. LOEC for 3,3',5-triCIBPA was >500 microg/L. When BPA was reacted with sodium hypochlorite (24 hours; residual chlorine at 1 ppm), however, complete decomposition of BPA and its chlorinated derivatives was observed. The decrease in BPA and its chlorinated derivatives paralleled the decrease in estrogenic potency evaluated by the induction of vitellogenin (VTG) in the serum of mature male Japanese medaka.
authors.affiliation: Institute of Environmental Ecology, Metocean Environment Inc, Oigawa-cho, Shida-gun, Shizuoka 421-0212, Japan. atabata@notes.metocean.co.jp
authors.forename: A
authors.initials: A
authors.lastname: Tabata
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: I
authors.initials: I
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Kamei
authors.forename: Y
authors.initials: Y
authors.lastname: Magara
authors.forename: Y
authors.initials: Y
authors.lastname: Terao
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D002713:Chlorine / Q000737:chemistry*; D004703:Endocrine System / Q000187:drug effects; D004781:Environmental Exposure; D008297:Male; D009990:Oryzias; D010636:Phenols / Q000737:chemistry / Q000633:toxicity*; D012973:Sodium Hypochlorite / Q000032:analysis / Q000737:chemistry; D013997:Time Factors; D014818:Vitellogenesis / Q000187:drug effects; D014819:Vitellogenins / Q000097:blood*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002713:Chlorine; D010636:Phenols; D012973:Sodium Hypochlorite; D014819:Vitellogenins; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds