Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors.
The use of drug-antibody conjugates affords a method for the targeted delivery of anticancer drugs specifically to cancer cells. Monoclonal antibodies alone usually do not possess high therapeutic efficacy, however, they are capable of targeting tumor markers selectively. We have prepared taxoids with significantly higher cytotoxicity than paclitaxel and docetaxel. These taxoids now meet the high potency required for use in a targeted-delivery approach using monoclonal antibodies. The synthesis and biological evaluation of these taxoids are reported.
Baloglu
Erkan
E
ImmunoGen, Inc., 128 Sidney Street, Cambridge, MA 02139, USA. erkan.baloglu@immunogen.com
Miller
Michael L
ML
Roller
Elizabeth E
EE
Cavanagh
Emily E
EE
Leece
Barbara A
BA
Goldmacher
Victor S
VS
Chari
Ravi V J
RV
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis*; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D043823:Taxoids / Q000008:administration & dosage / Q000138:chemical synthesis*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D043823:Taxoids