[Study on hemodynamic changes and cardiac troponin I level in pig model of acute experimental pulmonary embolism].
OBJECTIVE
To evaluate the hemodynamic effects and cardiac troponin I (cTn I), creatine kinase-MB (CK-MB), myoglobin (Mb) releasing kinetics of acute experimental pulmonary embolism of pigs.


METHODS
Sixteen juvenile pigs, of either gender and weighing 30 to 40 kg were studied, 8 in the embolism group and 8 in the control group. The 8 embolism animals received 0.1 g/kg polystyrene beads (diameter range 0.65 to 0.67 mm) suspended in 0.9% saline by venous injection. Pulmonary arterial pressure (PAP), systemic arterial pressure (SAP), pulmonary capillary wedged pressure (PCWP), cardiac output (CO), blood gases and serum cTn I, CK-MB, and Mb were measured before and immediately, 30 min, 1 hour, 2 hour, and 3 hour after acute pulmonary embolism.


RESULTS
PAP was increased to 2 - 3 fold of the baseline and the control level immediately, and then decreased to the baseline level in 2 to 3 hours. Serum cTn I and Mb increased significantly after embolism and remained at a higher level through the 3 hour experimental procedure. The CK-MB was not changed after acute pulmonary embolism.


CONCLUSIONS
Acute pulmonary embolism caused lung gas exchange abnormality and acute pulmonary hypertension. The hemodynamic effects of acute pulmonary embolism include injury to the myocardial cells and releasing of cTn I and Mb to blood stream. cTn I can be detected in the early phase of acute pulmonary embolism, and maybe a useful marker in diagnosis and management of acute pulmonary embolism.
Yang
Hong-shen
HS
Respiratory Department, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Pan
Wen-sen
WS
Zhang
Lu-tao
LT
Guan
Ji-tao
JT
Ma
Jun-yi
JY
Ma
Ning
N
Fu
Xiang-hua
XH
D000208:Acute Disease; D000818:Animals; D001784:Blood Gas Analysis; D052279:Creatine Kinase, MB Form / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006439:Hemodynamics; D008297:Male; D009211:Myoglobin / Q000097:blood*; D011655:Pulmonary Embolism / Q000097:blood / Q000503:physiopathology*; D013552:Swine; D019210:Troponin I / Q000097:blood*
D009211:Myoglobin; D019210:Troponin I; D052279:Creatine Kinase, MB Form