Role of lymphadenectomy in management of adenocarcinoma of the endometrium.
OBJECTIVE
To review the role of lymphadenectomy (LND) for patients with endometrial adenocarcinoma.


METHODS
A review was undertaken of the English Language literature dealing with the role of LND for patients with endometrial adenocarcinoma (EC).


RESULTS
The prognostic value of node status for EC patients has been recognized. LND performed by experienced surgeons has acceptable morbidity. Multiple series have suggested that significantly less external beam radiation is given to patients with known negative nodes. The decreased use of postop whole pelvic radiation has potential cost savings. However a survival advantage for LND has not yet been proven in a randomized clinical trials. United Kingdom investigators have begun a trial to determine if there is a demonstrable survival advantage for EC patients who undergo LND.


CONCLUSIONS
Although the morbidity, potential cost savings, and prognostic impact of node status are well accepted, it remains controversial as to whether LND provides a survival advantage. Trials are underway.
Look
K Y
KY
Obstetrics-Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202 (USA).
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D016032:Randomized Controlled Trials as Topic