title: [Clinical peculiarities of optic neuritis and alterations of local immune response in patients with multiple sclerosis].
abstract: Multiple sclerosis (MS) is a severe organic disease of the central nervous system (CNS) affecting mostly young people. Optic neuritis (ON) is one of the first manifestations of the disease in approximately 75% of cases. The autoimmune reactions to myelin antigens play a key role in ON pathogenesis of MS. The pro- and anti-inflammatory unbalance is the most important factor of the origin, development and stabilization of CNS changes. Presented are the data on alterations of the levels of pro- and anti-inflammatory cytokines TNF-alpha, IF-gamma and antibodies to MBP and anti DNA in patient's tears. The clinical peculiarities of ON in MS correlating with immunological alterations are established.
authors.forename: V V
authors.initials: VV
authors.lastname: Naroev
authors.forename: I Z
authors.initials: IZ
authors.lastname: Karlova
authors.forename: A N
authors.initials: AN
authors.lastname: Boĭko
authors.forename: O V
authors.initials: OV
authors.lastname: Zaĭtsev
authors.forename: E I
authors.initials: EI
authors.lastname: Gusev
mesh_terms: D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology*; D009902:Optic Neuritis / Q000209:etiology* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D007074:Immunoglobulin G; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma