title: Screening of isolates from faeces for carbapenem-resistant Bacteroides strains; existence of strains with novel types of resistance mechanisms.
abstract: Isolates from faecal samples (n = 224) from the UK and Hungary were screened for carbapenem-resistant Bacteroides strains and were consecutively investigated for the resistance mechanisms through detection of cfiA genes, the presence or lack of insertion sequence insertions in their upstream regions and the production of carbapenemase activities. In this way, a significant number of strains (n = 7, 3.1%) were recovered. They included 2 Bacteroides fragilis strains (one in each country) which harboured cfiA genes, but which were not activated by insertion sequence elements; this is reminiscent of some novel clinical B. fragilis strains. The cfiA-negative strains exhibited lower levels of carbapenem resistance and varying levels of carbapenemase activity, suggesting that other resistance mechanisms may also exist.
authors.affiliation: Department of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, H-6725 Szeged, Somogyi Béla tér 1, Hungary. soki@mlab.szote.u-szeged.hu
authors.forename: József
authors.initials: J
authors.lastname: Sóki
authors.forename: Richard
authors.initials: R
authors.lastname: Edwards
authors.forename: Edit
authors.initials: E
authors.lastname: Urbán
authors.forename: Eleonóra
authors.initials: E
authors.lastname: Fodor
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Beer
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Nagy
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001439:Bacteroides / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D001442:Bacteroides Infections / Q000382:microbiology; D015780:Carbapenems / Q000494:pharmacology*; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D004251:DNA Transposable Elements; D001618:beta-Lactamases; C063912:carbapenemase