Sulthiame in childhood epilepsy.
BACKGROUND
Sulthiame is a central carbonic anhydrase inhibitor found to be effective for both partial and generalized seizures. It has been in use in some European countries and in Israel for over 30 years. The aim of the present study was to evaluate the efficacy and tolerability of sulthiame in childhood epilepsy by conducting a multicenter, retrospective study of patients who received this drug.


METHODS
The charts of 125 consecutive epilepsy patients treated with sulthiame as monotherapy or add-on therapy were reviewed.


RESULTS
Twenty-nine out of 39 patients with benign focal epilepsy of childhood became seizure-free. Total seizure control was also achieved in 17 of 42 patients with symptomatic, non-refractory localization-related epilepsy, and in all 10 cases with juvenile myoclonic epilepsy. Complete normalization of the EEG occurred in 13 of 20 patients with benign partial epilepy of childhood. Side-effects were minimal and caused discontinuation of treatment in only seven children.


CONCLUSIONS
The high tolerability, efficacy, convenience of use and low cost suggest that sulthiame should become a first line drug in the benign partial epilepsies of childhood and juvenile myoclonic epilepsy. It also has a role as add-on treatment in other partial and myoclonic epilepsies.
Ben-Zeev
Bruria
B
Pediatric Neurology Unit, Sheba Medical Center, Ramat-Gan, Israel.
Watemberg
Nathan
N
Lerman
Pinchas
P
Barash
Itshak
I
Brand
Nathan
N
Lerman-Sagie
Tally
T
D000293:Adolescent; D001315:Australia; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005858:Germany; D006801:Humans; D006985:Hyperventilation / Q000139:chemically induced; D007494:Ireland; D007557:Israel; D008297:Male; D020714:Maximum Tolerated Dose; D010292:Paresthesia / Q000139:chemically induced; D012189:Retrospective Studies; D013843:Thiazines / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D000096926:Benzenesulfonamides
D013843:Thiazines; C084593:sulthiame; D000096926:Benzenesulfonamides