title: [Expression of cellular adhesion molecules and HLA-DR antigen on vascular endothelial cells in hemangiomas.].
abstract: OBJECTIVE
  To investigate the expression and function of the adhesion molecules ICAM-3, CD34 and HLA-DR antigen on endothelial cells of hemangiomas in different stages.
  
  
  METHODS
  SABC immunohistochemical technique was used to examine the expression of ICAM-3, CD34 and HLA-DR on vascular endothelial cells. Seventy-six specimens including 28 proliferating hemangiomas, 22 involuting hemangiomas, 18 vascular deformity and 8 normal skin tissue were obtained from infants and children for the experiment.
  
  
  RESULTS
  The results showed: (1) both ICAM-3 and CD34 had high expression in proliferating hemangiomas, but poor or even no expression in involuting hemangiomas. There was a significant difference (P<0.001) between the two phases. Both ICAM-3 and CD34 had almost no expression in vascular deformity and normal skin tissue, significantly different from hemangiomas (P<0.001).(2) HLA-DR expression was closely related to the high differentiation phase of vascular epithelial cells. In the proliferating phase, HLA-DR didn't express, while it expressed highly as endothelial cells were in well-matured involuting phase. These differences were significant (P<0.001).
  
  
  CONCLUSIONS
  ICAM-3 and CD34 might play a role in the early stage of angiogenesis and take part in the pathological genesis and regression process of hemangiomas by regulating endothelial cells adhesion; HLA-DR might be related either to acquisition of a mature phenotype or to an activated state of the endothelial cells.
authors.affiliation: Department of Oral Maxillofacial Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. qinxj1989@sina.com
authors.forename: Xing-jun
authors.initials: XJ
authors.lastname: Qin
authors.forename: Pan
authors.initials: P
authors.lastname: Qiu
authors.forename: Xu-kai
authors.initials: XK
authors.lastname: Wang
authors.forename: Chang-fu
authors.initials: CF
authors.lastname: Sun
authors.forename: Qing-chang
authors.initials: QC
authors.lastname: Li
authors.forename: Yu-chen
authors.initials: YC
authors.lastname: Han
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Guan
mesh_terms: D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002648:Child; D042783:Endothelial Cells / Q000378:metabolism; D006684:HLA-DR Antigens / Q000378:metabolism*; D006391:Hemangioma / Q000378:metabolism*; D006801:Humans; D007223:Infant
chemical_list: D015815:Cell Adhesion Molecules; D006684:HLA-DR Antigens