title: Use of cyclosporine to treat granulomatous meningoencephalitis in three dogs.
abstract: Use of cyclosporine to treat granulomatous meningoencephalitis in three dogs Three dogs with a presumptive diagnosis of granulomatous meningoencephalitis were treated with orally administered cyclosporine. In 2 dogs, cyclosporine administration replaced initial corticosteroid administration, and in 1 dog, cyclosporine was the only treatment used. One dog had the focal form of the disease in the brainstem, 1 dog had the focal form in the forebrain associated with a concurrent ocular form, and 1 dog had the disseminated form of disease. At 12-month follow-up, the 2 dogs with the focal form of the disease had no clinical signs. The dog with the disseminated form improved only partially, and euthanasia was performed 3 weeks after initial evaluation. Cyclosporine was considered effective at an initial dosage of 6 mg/kg (2.7 mg/lb) every 12 hours. Adverse effects associated with cyclosporine administration included transient lymphopenia, excessive shedding, and focal symmetric hair discoloration.
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Filippo P
authors.initials: FP
authors.lastname: Adamo
authors.forename: Robert T
authors.initials: RT
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006099:Granuloma / Q000188:drug therapy / Q000662:veterinary*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy / Q000662:veterinary*; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine