title: Experimental study of effect of perfluorohexyloctane to retina.
abstract: OBJECTIVE
  To investigate the effect of perfluorohexyloctane to the retina of rabbit eyes.
  
  
  METHODS
  Perfluorohexyloctane (experimental group) or BSS(control group) into vitreous cavities of fifteen vitrectomized New Zealand white rabbits. A slit-lamp biomicroscope and an indirect ophthalmoscope were used to examine all the eyes pre- and postoperation. Histopathological examination was performed after the rabbits were sacrificed.
  
  
  RESULTS
  Perfluorohexyloctane was injected into the vitreous cavity forming a single large layerclear globe. No retinal detachment and cataract were found. The edema of outer plexiform was significant, and then get a darker cytoplasm and nucleoplasm.
  
  
  CONCLUSIONS
  Perfluorohexyloctane in vitreous cavity had significant side effects on retina. As a silicone solvent, it should be removed out completely after injection. We don't recommend to use it as a new intraocular tamponade.
authors.affiliation: Zhongshan Ophthalmic center, Sun Yet-san University, Guangzhou 510060 , China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Li
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ding
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Guanguang
authors.initials: G
authors.lastname: Feng
authors.forename: Huling
authors.initials: H
authors.lastname: Zheng
mesh_terms: D000818:Animals; D005260:Female; D005466:Fluorocarbons / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D014822:Vitreous Body / Q000187:drug effects
chemical_list: D005466:Fluorocarbons; C118616:perfluorohexyl-octan