title: Topical application of nerve growth factor in human diabetic foot ulcers. A study of three cases.
abstract: Three diabetic patients with leg or foot ulcers unresponsive to conventional therapies were treated with topical application of Nerve Growth Factor (NGF). The results showed that NGF promotes healing after 5-14 weeks of treatment. This study suggests that the use of topical application of NGF may represent a new useful tool for the management of difficult diabetic ulcers.
authors.affiliation: Department of Medicine, Section of Rheumatology, University of Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Generini
authors.forename: M A
authors.initials: MA
authors.lastname: Tuveri
authors.forename: M
authors.initials: M
authors.lastname: Matucci Cerinic
authors.forename: F
authors.initials: F
authors.lastname: Mastinu
authors.forename: L
authors.initials: L
authors.lastname: Manni
authors.forename: L
authors.initials: L
authors.lastname: Aloe
mesh_terms: D000287:Administration, Topical; D000368:Aged; D017719:Diabetic Foot / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D020932:Nerve Growth Factor