No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells.
Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.
Leelawat
Kawin
K
Department of Anatomy, Faculty of Science, Mahidol University, Thailand. kawin@tubtim.cri.or.th
Engprasert
Surang
S
Pongchai-rerk
Urai
U
Tuchinda
Supatip
S
Suthipintawong
Cheepsumon
C
Leardkamolkarn
Vijittra
V
D018256:Adenomatous Polyps / Q000378:metabolism; D002278:Carcinoma in Situ / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism*; D006680:HLA Antigens / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D020133:Reverse Transcriptase Polymerase Chain Reaction
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I