title: Novel insights into coronary lumen preservation during progression of coronary atherosclerosis in coronary atherosclerosis-prone rabbits.
abstract: BACKGROUND
  In coronary atherosclerosis-prone Watanabe heritable hyperlipidaemic (WHHLCA) rabbits, an animal model for low-density lipoprotein receptor deficiency and spontaneous coronary atherosclerosis, the coronary arteries show compensatory remodelling during the progression of atherosclerosis. Therefore, we analysed coronary remodelling of WHHLCA rabbits quantitatively using a method that eliminates the limitations of previous analytical methods.
  
  
  METHODS
  Arterial remodelling was evaluated in perfusion-fixed coronary arteries of 11 WHHLCA rabbits using both new and previous analyses. With the improved methods removing limitations on quantitative analysis of arterial remodelling, we evaluated how lumen area or arterial size changed with accumulating atherosclerotic plaques compared to before plaque development. The original lumen area before plaque development was calculated using the diameter-length relationship. Wall shear stress change ratio was calculated from changes in arterial size.
  
  
  RESULTS
  Using the old analytical method (and as seen in similar human studies), lumen area increased up to a level of 29% of cross-sectional narrowing. However, with the improved analysis, in cross-sectioning narrowing at levels below 10%, the lumen area modestly decreased, and when the cross-sectional narrowing ranged from 10-68%, the lumen area remained constant, and diminished sharply despite continued remodelling when cross-sectional narrowing reached 70% or above. Arterial remodelling progressed quantitatively to a slight increase in arterial wall shear stress as well as lumen area up to a level of 70% cross-sectional narrowing.
  
  
  CONCLUSIONS
  These findings demonstrate marked influences of arterial tapering and individual variation of arterial size on quantitative analysis of arterial remodelling, and provide the novel insight that coronary compensatory remodelling in atherosclerosis maintains the lumen size up to levels of 70% cross-sectional narrowing in proportion to wall shear stress.
authors.affiliation: The Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Shiomi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ito
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Katsuya
authors.initials: K
authors.lastname: Yoshida
authors.forename: K Lance
authors.initials: KL
authors.lastname: Gould
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000473:pathology* / Q000503:physiopathology*; D003331:Coronary Vessels / Q000473:pathology* / Q000503:physiopathology*; D018450:Disease Progression; D008297:Male; D011817:Rabbits