title: Preoperative evaluation of biliary anatomy in adult live liver donors with volumetric mangafodipir trisodium enhanced magnetic resonance cholangiography.
abstract: Accurate preoperative depiction of biliary anatomy is not always adequately accomplished by imaging techniques in living donor liver transplantation (LDLT). We present the results of a prospective study designed to evaluate the ability of mangafodipir trisodium (Mn-DPDP)-enhanced magnetic resonance (MR) cholangiography (MRC) for this purpose in a series of 25 adult living liver donors (LLDs). We also analyze if a simple or a more complex surgical procedure can be preoperatively suggested for biliary reconstruction in the recipients. Findings on MRC were compared with operative cholangiography (OC). A conventional distribution with a right hepatic duct (RHD) longer than 1 cm anticipated a simple procedure (duct-to-duct anastomosis or hepaticojejunostomy [HJ]). A shorter RHD or any variant were predictors of a more complex surgery (bench ductoplasty or multiple anastomoses). Agreement between MRC and OC in assessing the biliary anatomy was measured using the kappa statistic, and differences between the kind of surgery predicted at MRC and the biliary anastomosis performed were evaluated with Fisher's exact test. Normal variants were present in 16 / 25 donors (64%). MRC was accurate in depicting the pattern of bile duct distribution observed at OC in 22 / 25 (88%) donors (kappa = .831), and correctly predicted the complexity of biliary anastomosis in the recipient in 22 / 25 (88%) donors. No significant differences were observed between complexity of biliary surgery proposed at MRC and the final surgery performed (P = .002). In conclusion, Mn-DPDP-enhanced MRC is highly accurate in depicting the biliary duct anatomy and can be used preoperatively for surgical planning in LDLT.
authors.affiliation: Department of Radiology, Centre de Diagnostic per la Imatge Clinic, Institut Clinic de Malalties Digestives, Hospital Clinic, Institut d'Investigacions Biomediques August PiI Sunyer, University of Barcelona, Barcelona, Spain. jrayuso@clinic.ub.es
authors.forename: Juan R
authors.initials: JR
authors.lastname: Ayuso
authors.forename: Carmen
authors.initials: C
authors.lastname: Ayuso
authors.forename: Ernest
authors.initials: E
authors.lastname: Bombuy
authors.forename: Carmen
authors.initials: C
authors.lastname: De Juan
authors.forename: Josep M
authors.initials: JM
authors.lastname: Llovet
authors.forename: Teresa M
authors.initials: TM
authors.lastname: De Caralt
authors.forename: Marcel
authors.initials: M
authors.lastname: Sánchez
authors.forename: Mario
authors.initials: M
authors.lastname: Pagés
authors.forename: Jordi
authors.initials: J
authors.lastname: Bruix
authors.forename: Juan C
authors.initials: JC
authors.lastname: García-Valdecasas
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000033:anatomy & histology*; D002758:Cholangiography / Q000379:methods*; D003287:Contrast Media / Q000494:pharmacology*; D004492:Edetic Acid / Q000031:analogs & derivatives*; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D008279:Magnetic Resonance Imaging / Q000379:methods; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011446:Prospective Studies; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid