Reversible amantadine-induced corneal edema in an adolescent.
OBJECTIVE
To document reversible corneal edema caused by amantadine in a pediatric patient.


METHODS
A 14-year-old boy with a neurologic tremor was referred for bilateral visual loss. Our examination disclosed bilateral corneal edema without ocular inflammation. Pachymetry confirmed significantly increased corneal thickness above 900 microm.


RESULTS
Review of the patient's medical information revealed recent institution of amantadine as a means to control the patient's tremor. On cessation of this agent, rapid resolution of corneal edema and recovery of visual acuity occurred. Repeat pachymetry measurement revealed normal corneal thickness.


CONCLUSIONS
In cases of corneal edema and in the absence of any identifiable ocular causes, a review of toxic effects of systemic medication should be undertaken. Amantadine can cause corneal decompensation and needs to be considered as part of the differential diagnosis of corneal edema.
Hughes
Bradley
B
Cornea Service, Jones Eye Institute, and Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Feiz
Vahid
V
Flynn
Steven B
SB
Brodsky
Michael C
MC
D000293:Adolescent; D000547:Amantadine / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects*; D015715:Corneal Edema / Q000139:chemically induced* / Q000503:physiopathology; D015259:Dopamine Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D014792:Visual Acuity
D015259:Dopamine Agents; D000547:Amantadine