Serum and follicular resistin levels in women with polycystic ovarian syndrome during IVF-stimulated cycles.
BACKGROUND
Resistin is a hormone linking obesity and insulin resistance. The aim of this study was to compare resistin levels in serum or follicular fluid from women with polycystic ovarian syndrome (PCOS) and controls, both of whom were undergoing IVF.


METHODS
We compared serum and follicular resistin levels in 21 PCOS women and in 18 healthy, normal ovulation, age- and body mass index (BMI)-matched non-PCOS women undergoing IVF. Correlations between serum or follicular fluid resistin levels and reproductive outcome were evaluated.


RESULTS
There was no significant difference in either serum or follicular resistin levels between the control group and the PCOS group as a whole or those with insulin resistance [homeostasis model assessment of insulin resistance index applied to oral glucose tolerance test (HOMA(OGTT)) <4.7]. However, resistin levels in follicular fluid were unexpectedly significantly lower than serum levels (P<0.0001) in both the PCOS and control groups. No significant correlation was found between resistin levels and BMI, estradiol, LH, or fasting or 2 h glucose or insulin levels or between follicular resistin levels and fertilization rate, implantation rate, clinical pregnancy rate, or early miscarriage rate in PCOS.


CONCLUSIONS
Resistin is unlikely to be a major determining factor in the growth and maturation of oocytes during IVF-stimulated cycles in PCOS.
Seow
Kok-Min
KM
Department of Obstetrics and Gynecology, E-Da Hospital/I-Shou University, Kaohsiung County, Institute of Clinical Medicine and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan.
Juan
Chi-Chang
CC
Hsu
Yung-Pei
YP
Ho
Low-Tone
LT
Wang
Yuan-Yung
YY
Hwang
Jiann-Loung
JL
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D006729:Hormones, Ectopic / Q000097:blood* / Q000378:metabolism*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000378:metabolism / Q000628:therapy; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism* / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D052243:Resistin
D006729:Hormones, Ectopic; C499624:RETN protein, human; D052243:Resistin