Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.
Cao
Shugeng
S
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.
Gao
Zhijie
Z
Thomas
Shannon J
SJ
Hecht
Sidney M
SM
Lazo
John S
JS
Kingston
David G I
DG
D000818:Animals; D019951:DNA Polymerase beta / Q000037:antagonists & inhibitors*; D003857:Deoxyuridine / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008190:Lyases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C493698:17-O-isoprenyldictyoceratin-C; D004791:Enzyme Inhibitors; D011809:Quinones; D012717:Sesquiterpenes; C493697:dictyoceratin-C; C467077:ilimaquinone; D019951:DNA Polymerase beta; D008190:Lyases; D003857:Deoxyuridine