title: 4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials.
abstract: Supercritical CO2 selectively extracted a series of 4-alkyl and 4-phenyl 5,7-dihydroxycoumarins from Mesua ferrea blossoms. Chemical modifications of the isolated compounds allowed us to confirm the structures elucidated by spectroscopic means and to prepare new derivatives amenable to SAR studies and potential pharmaceutical development. Biological investigations towards the screening on a number of bacteria strains and Plasmodium falciparum, identified compounds 1-9 as weak antiprotozoal agents and potent antibacterials on resistant Gram-positive strains.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy. luisella.verotta@unimi.it
authors.forename: Luisella
authors.initials: L
authors.lastname: Verotta
authors.forename: Erminio
authors.initials: E
authors.lastname: Lovaglio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vidari
authors.forename: Paola Vita
authors.initials: PV
authors.lastname: Finzi
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Neri
authors.forename: Alessandro
authors.initials: A
authors.lastname: Raimondi
authors.forename: Silvia
authors.initials: S
authors.lastname: Parapini
authors.forename: Donatella
authors.initials: D
authors.lastname: Taramelli
authors.forename: Antonella
authors.initials: A
authors.lastname: Riva
authors.forename: Ezio
authors.initials: E
authors.lastname: Bombardelli
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry*; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D035264:Flowers / Q000737:chemistry; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D003374:Coumarins