title: [A case of allergic granulomatosis and angiitis (Churg-Strauss syndrome) in a 15-year-old girl].
abstract: A 15-year-old girl with a 6-month history of bronchial asthma was admitted to our hospital because of fever, dyspnea, weight loss, dysesthesia, muscle weakness, gait disturbance and purpuric rash. In addition, leukocytosis, hypereosinophilia and elevation of CRP were observed. Chest radiograph and computed tomography on admission showed non-segmental patchy air-space consolidation in both lung fields. Skin biopsy was performed and the pathologic diagnosis was necrotizing arteritis with eosinophilic infiltration. Transbronchial lung biopsy revealed eosinophilic pneumonia. From the clinical course, laboratory data and pathologic findings, the diagnosis of allergic granulomatosis and angiitis (Churg-Strauss syndrome) was made. Following the skin and lung biopsies, intravenous pulse corticosteroid and oral prednisolone treatment was started and her clinical findings improved. Angiitis with allergic granulomatosis is a vasculitis that is found in adults. This is an extremely rare and interesting case of angiitis with allergic granulomatosis in childhood.
authors.affiliation: The Division of Respiratory Disease, Kawasaki Medical School, Kawasaki Hospital.
authors.forename: Kazue
authors.initials: K
authors.lastname: Fujita
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamato
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Kurihara
authors.forename: Kohichi
authors.initials: K
authors.lastname: Osaki
authors.forename: Hideo
authors.initials: H
authors.lastname: Ohba
authors.forename: Junichi
authors.initials: J
authors.lastname: Nakamura
authors.forename: Niro
authors.initials: N
authors.lastname: Okimoto
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone