title: Effect of different iodine intake on schoolchildren's thyroid diseases and intelligence in rural areas.
abstract: BACKGROUND
  Reports are increasingly appearing on the side effects caused by excessive iodine intake. Our objective was to find out whether iodine excess would impair the thyroid function and intelligence of schoolchildren in rural areas of China.
  
  
  METHODS
  A comparative epidemiological study was made on thyroid function and intelligence of the schoolchildren in the areas of low, moderate or excessive intake of iodine. In the area of low intake of iodine (Panshan, Liaoning province, median urinary iodine (MUI) was 99 microg/L), of moderate intake of iodine (Zhangwu, Liaoning Province, MUI was 338 microg/L) and of excessive intake of iodine (Huanghua, Hebei Province, MUI was 631 microg/L). The numbers of schoolchildren from each area selected to take part in a Chinese version of Raven's Test were 190, 236 and 313, respectively, and then 116, 110 and 112 of them were tested for thyroid function, thyroid autoantibody (TAA) and urinary iodine (UI).
  
  
  RESULTS
  There were no significant differences in the incidences of overt hyperthyroidism, subclinical hyperthyroidism and overt hypothyroidism in Panshan, Zhangwu and Huanghua. But significant differences were found in the incidences of subclinical hypothyroidism (P = 0.001) in these three areas. The incidences of subclinical hypothyroidism in Huanghua and Zhangwu were 4.76 and 3.37 times higher than that in Panshan. TAA were negative in all the schoolchildren with subclinical hypothyroidism except for one. No significant difference was found among the rates of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in these three areas. Mean serum thyroglobulin (TG) value of Huanghua was markedly higher than those of the other two (P = 0.02). Mean serum TG value of Zhangwu was higher than that of Panshan but the difference was not significant. Mean IQ value of the schoolchildren in Huanghua was markedly higher than that for Zhangwu (P = 0.001). Mean IQ value of the schoolchildren in Panshan was lower than that of Huanghua and higher than that of Zhangwu but, again, the differences were not significant.
  
  
  CONCLUSIONS
  The increase of iodine intake may increase the risk for schoolchildren of subclinical hypothyroidism. In the area of iodine excess, most of the subclinical hypothyroidism cases are not of autoimmune origin. No obvious effect of excess iodine was found on mental development of schoolchildren.
authors.affiliation: Department of Endocrinology, First Hospital of China Medical University, Shenyang, China. gaotianshu67@yahoo.com.cn
authors.forename: Tian-shu
authors.initials: TS
authors.lastname: Gao
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Teng
authors.forename: Zhong-yan
authors.initials: ZY
authors.lastname: Shan
authors.forename: Ying
authors.initials: Y
authors.lastname: Jin
authors.forename: Hai-xia
authors.initials: HX
authors.lastname: Guan
authors.forename: Xiao-chun
authors.initials: XC
authors.lastname: Teng
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Wang
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Shi
authors.forename: Ya-jie
authors.initials: YJ
authors.lastname: Tong
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007360:Intelligence; D007453:Iodide Peroxidase / Q000276:immunology; D007455:Iodine / Q000008:administration & dosage*; D008297:Male; D015995:Prevalence; D012423:Rural Health; D013954:Thyroglobulin / Q000276:immunology; D013959:Thyroid Diseases / Q000453:epidemiology*; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin; D013954:Thyroglobulin; D007455:Iodine; D007453:Iodide Peroxidase