[The expression difference of VEGF, PDGF/dThdPase and MVD on primary hypopharyngeal carcinoma and metastasis lymph nodes].
OBJECTIVE
To evaluate the difference of angiogenic factors PDGF/dThdPase,VEGF expression and microvessel density (MVD) in primary hypopharyngeal tumor and metastasis lymph nodes.


METHODS
The author studied immunohistochemically a series of 48 primary hypopharyngeal carcinoma patients and metastasis lymph nodes were calculated.


RESULTS
The percentage of VEGF was 25.38% in primary tumor and 21.52% in lymph nodes. No significant difference was found. The percentage of PDGF/dThdPase was 29.59% in primary tumor and and 21.2% in lymph nodes. This showed significent difference. VEGF showed significent difference between live and death group(P < 0.05) and among differentiation group (P < 0.05). MVD showed significant difference between live and death group, early and late stage group, and T1-2 and T3-4 group (P < 0.05). There were statistically significant correlations between the score of PDGF/ dThdPase, or VEGF and the score of MVD respectively.


CONCLUSIONS
The present study suggests that there was a correlation between VEGF or PDGF and MVD. VEGF and MVD were possible to be prognostic discriminators in hypopharyngeal carcinoma. PDGF expression in lymph nodes was significant higher than in primary tumors, and MVD expression in primary tumor was significant higher than in lymph nodes.
Dong
Pin
P
Department of Otolaryngology-Head and Neck Surgery, the First People's Hospital,Shanghai 200080.
Yoshimi
Miyajima
M
Tadashi
Nakashima
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism* / Q000556:secondary; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A