title: Effects of trimethoprim-sulfadiazine on tear production and the fluctuations of Schirmer tear test values in horses.
abstract: The objectives of this study were to observe the effects of trimethoprim-sulfadiazine on equine tear production and to determine normal fluctuations in Schirmer tear test (STT) values in horses. A randomized, placebo-controlled, blinded clinical trial measuring STT values in 15 horses over an 8-week period was performed. The treatment group (eight horses) received 30 mg/kg trimethoprim-sulfadiazine orally once a day and the control group (seven horses) received placebo (flour) at the same time. All horses were housed outdoors throughout the study. Schirmer tear test values were measured at 0, 2, 4, 6 and 8 weeks, and 4 weeks after discontinuation of treatment. There were no significant differences in tear production between the treated and control groups. Fluctuations in STT were observed and may result from individual and environmental variations. Trimethoprim-sulfadiazine did not decrease tear production in the horses in this study. Horses normally experience periodic fluctuations in STT values.
authors.affiliation: Department of Veterinary Clinical Sciences, PO Box 647060, Pullman, WA 99164-7060, USA.
authors.forename: Chantal M
authors.initials: CM
authors.lastname: Rothschild
authors.forename: Debra C
authors.initials: DC
authors.lastname: Sellon
authors.forename: Gary M
authors.initials: GM
authors.lastname: Bryan
authors.forename: John M
authors.initials: JM
authors.lastname: Gay
authors.forename: Melissa T
authors.initials: MT
authors.lastname: Hines
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006736:Horses / Q000502:physiology*; D007765:Lacrimal Apparatus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D011934:Reagent Strips; D013411:Sulfadiazine / Q000009:adverse effects / Q000494:pharmacology*; D013666:Tears / Q000378:metabolism*; D014295:Trimethoprim / Q000009:adverse effects / Q000494:pharmacology*; D000096926:Benzenesulfonamides
chemical_list: D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D011934:Reagent Strips; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides