Mutation of a single lytic transglycosylase causes aberrant septation and inhibits cell separation of Neisseria gonorrhoeae.
The function of lytic peptidoglycan transglycosylases is poorly understood. Single lytic transglycosylase mutants of Escherichia coli have no growth phenotype. By contrast, mutation of Neisseria gonorrhoeae ltgC inhibited cell separation without affecting peptidoglycan monomer production. Thus, LtgC has a dedicated function in gonococcal cell division.
Cloud
Karen A
KA
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison Medical School, Madison, Wisconsin, USA.
Dillard
Joseph P
JP
D002455:Cell Division; D015169:Colony Count, Microbial; D015964:Gene Expression Regulation, Bacterial; D016695:Glycosyltransferases / Q000378:metabolism*; D046529:Microscopy, Electron, Transmission; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000166:cytology / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D010457:Peptidoglycan / Q000378:metabolism*
D010457:Peptidoglycan; D016695:Glycosyltransferases