Mitogenic stimulation of transcription by RNA polymerase III.
Regulation of protein synthesis is an important aspect of growth control. RNA polymerase (pol) III plays a key role in this process by catalysing production of tRNA and 5 S rRNA. Growth factors trigger a rapid increase in pol III activity and this is essential for cell proliferation. The transcription factor TFIIIB plays a key role in controlling pol III activity and is a target for regulation by a number of mechanisms. This review will focus on how TFIIIB is targeted by these proteins in response to mitogen stimulation.
Mauger
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Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK.
Scott
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D000818:Animals; D002455:Cell Division / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D012320:RNA Polymerase III / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000378:metabolism; D035361:Transcription Factor TFIIIB / Q000378:metabolism; D019474:Transcription Factors, TFIII / Q000378:metabolism; D014158:Transcription, Genetic; D000098832:Transcription Factor TFIIIC
D006133:Growth Substances; D016160:Retinoblastoma Protein; D035361:Transcription Factor TFIIIB; D019474:Transcription Factors, TFIII; D000098832:Transcription Factor TFIIIC; D012320:RNA Polymerase III