Early plasmacytoid dendritic cell changes predict plasma HIV load rebound during primary infection.
During human immunodeficiency virus (HIV) infection, interruption of highly active antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here, the number of pDCs was measured by flow cytometry before, during, and after receipt of HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was evidenced between pDC counts after 1 month of HAART and mean plasma virus load after interruption of HAART (r2=0.85; Spearman's partial rho =-0.92; P=.03). pDC counts during treatment might help predict immune replication control after interruption of HAART.
Pacanowski
Jerome
J
Département de Maladies Infectieuses et Tropicales, Hôpital St. Antoine, Assistance Publique--Hopitaux de Paris, Universite Paris VI, Paris, France.
Develioglu
Leyla
L
Kamga
Isabelle
I
Sinet
Martine
M
Desvarieux
Moïse
M
Girard
Pierre-Marie
PM
Hosmalin
Anne
A
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D002452:Cell Count; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D014766:Viremia