title: Single-suture craniosynostosis: a review of neurobehavioral research and theory.
abstract: OBJECTIVE
  To review research and theory regarding the neurobehavioral correlates and outcomes of single-suture, or isolated, craniosynostosis in children.
  
  
  METHODS
  A critical review of 17 studies of the hypothesized association between isolated craniosynostosis and neurodevelopment.
  
  
  RESULTS
  Isolated craniosynostosis is associated with a three- to fivefold increase in risk for cognitive deficits or learning/language disabilities. The causal basis for this association is unclear. No particular calvarial suture (sagittal, metopic, left or right unilateral coronal) has been associated with higher risk of problems. There is little evidence from quasi-experimental studies that cranioplastic surgery prevents or reduces risk of neurobehavioral impairment.
  
  
  CONCLUSIONS
  Future studies would benefit from larger samples and larger control groups; measures of specific neuropsychological functions (in addition to global cognition); analyses of neuropsychological status in relation to the severity and cortical impact of synostosis; and an examination of interactions between synostosis and social/family risk factors on neurodevelopment. Routine neurodevelopmental screening of young children with isolated craniosynostosis is recommended.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA. mspeltz@u.washington.edu
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Speltz
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Kapp-Simon
authors.forename: Michael
authors.initials: M
authors.lastname: Cunningham
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Marsh
authors.forename: Geraldine
authors.initials: G
authors.lastname: Dawson
mesh_terms: D001921:Brain / Q000254:growth & development*; D002648:Child; D002653:Child Behavior Disorders / Q000453:epidemiology*; D003072:Cognition Disorders / Q000453:epidemiology*; D003393:Cranial Sutures / Q000002:abnormalities*; D003398:Craniosynostoses / Q000453:epidemiology* / Q000523:psychology*; D006801:Humans; D011582:Psychological Theory; D012886:Skull / Q000254:growth & development*