[Effects of long-term administration of caffeine on fat storage in ovariectomized rats].
It is well known that obesity occurs in women with climacteric disorders. The aim of this study was to examine whether caffeine prevents obesity and bone loss in ovariectomized rats (ovx). Eight-week-old female Wistar rat were assigned to 4 groups: a sham-operated group fed the control diet (CE-2); an ovx-c group fed the control diet; an ovx-caf 0.15% group fed the control diet containing 1.5 g/kg of caffeine; and an ovx-caf 0.3% group fed the control diet containing 3 g/kg of caffeine. Body weights at 2-9 weeks and the final parametrail adipose tissue weights were significantly lower in the ovx-caf 0.3% group than in the ovx-c group. Food intakes were significantly lower in the ovx-caf 0.3% group than in the ovx-c group. After 9 weeks, the rats were killed and adipose tissues were sampled immediately. Basal lipolysis was increased in the ovx-caf 0.3% group fed the control diet containing 3 g/kg of caffeine than in the ovx-c group fed the control diet. The relative content of calcium (g/100 g body weight) in the ovx-caf 0.3% group was significantly increased compared with that in the ovx-c group. These results show a new possible role for caffeine in the prevention of lifestyle-related diseases.
Han
Li-Kun
LK
Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto 862-8502, Japan. hanlikun@hotmail.com
Kai
Fumi
F
Okuda
Hiromichi
H
D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D002110:Caffeine / Q000008:administration & dosage* / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D005260:Female; D006801:Humans; D008066:Lipolysis / Q000187:drug effects*; D008099:Liver / Q000033:anatomy & histology; D009765:Obesity / Q000209:etiology / Q000517:prevention & control*; D009929:Organ Size / Q000187:drug effects; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000517:prevention & control; D010052:Ovariectomy / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000033:anatomy & histology
D002110:Caffeine; D002118:Calcium