Discrete functional contributions of cerebral cortical foci in voluntary swallowing: a functional magnetic resonance imaging (fMRI) "Go, No-Go" study.
Brain-imaging studies have shown that visually-cued, voluntary swallowing activates a distributed network of cortical regions including the precentral and postcentral gyri, anterior cingulate cortex (ACC), insula, frontoparietal operculum, cuneus and precuneus. To elucidate the functional contributions of these discrete activation foci for swallowing, a "Go, No-Go" functional magnetic resonance imaging (fMRI) paradigm was designed. Brain activation associated with visually-cued swallowing was compared with brain activation evoked by a comparable visual cue instructing the subject not to swallow. Region-of-interest analyses performed on data from eight healthy subjects showed a significantly greater number of activated voxels within the precentral gyrus, postcentral gyrus, and ACC during the "Go" condition compared to the "No-Go" condition. This finding suggests that the precentral gyrus, postcentral gyrus, and ACC contribute primarily to the act of swallowing. In contrast, the numbers of activated voxels within the cuneus and precuneus were not significantly different for the "Go" and "No-Go" conditions, suggesting that these regions mediate processing of the cue to swallow. Together these findings support the view that the discrete cortical foci previously implicated in swallowing mediate functionally distinct components of the swallowing act.
Toogood
Jillian A
JA
Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, N6G 1H1, Canada.
Barr
Amy M
AM
Stevens
Todd K
TK
Gati
Joseph S
JS
Menon
Ravi S
RS
Martin
Ruth E
RE
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology*; D003679:Deglutition / Q000502:physiology*; D005260:Female; D006801:Humans; D016018:Least-Squares Analysis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male