title: Transitional cell carcinomas in four fishing cats (Prionailurus viverrinus).
abstract: Transitional cell carcinomas (TCC) of the urinary bladder were diagnosed in four related fishing cats (Prionailurus viverrinus). The major clinical sign in each case was persistent hematuria unresponsive to medical therapy. Cystotomy and biopsy provided an antemortem diagnosis in three of the fishing cats before euthanasia because of progression of clinical signs. The diagnosis was made in the fourth cat after euthanasia because of renal failure. Hematuria improved temporarily in one of the cats diagnosed antemortem and treated with piroxicam and carboplatin. Attempts to isolate a herpesvirus in two of the cats failed. Histopathologic appearance of the TCC was similar to that described for other species. TCC metastasis to the lungs was noted at necropsy in one cat; metastatic disease was not noted in the other fishing cats on gross or histopathologic examination. TCC of the urinary bladder appears to be more prevalent in fishing cats than in other species of domestic or nondomestic felids.
authors.affiliation: Veterinary Services Department, San Diego Zoo, P.O. Box 120551, San Diego, California 92112, USA.
authors.forename: Meg
authors.initials: M
authors.lastname: Sutherland-Smith
authors.forename: Catherine
authors.initials: C
authors.lastname: Harvey
authors.forename: Mark
authors.initials: M
authors.lastname: Campbell
authors.forename: Denise
authors.initials: D
authors.lastname: McAloose
authors.forename: Bruce
authors.initials: B
authors.lastname: Rideout
authors.forename: Patrick
authors.initials: P
authors.lastname: Morris
mesh_terms: D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D045989:Felidae; D005260:Female; D006417:Hematuria / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction / Q000662:veterinary; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*