Recombinational DNA repair: the ignored repair systems.
The recent finding of a role for the recA gene in DNA replication restart does not negate previous data showing the existence of recA-dependent recombinational DNA repair, which occurs when there are two DNA duplexes present, as in the case for recA-dependent excision repair, for postreplication repair (i.e., the repair of DNA daughter-strand gaps), and for the repair of DNA double-strand breaks. Recombinational DNA repair is critical for the survival of damaged cells.
Smith
Kendric C
KC
Emeritus Professor of Radiation Oncology (Radiation Biology), Stanford University School of Medicine, 927 Mears Ct., Stanford, CA 94305-1041, USA. kendric@stanford.edu
D001426:Bacterial Proteins / Q000378:metabolism; D004247:DNA / Q000378:metabolism / Q000528:radiation effects; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase; D029968:Escherichia coli Proteins / Q000378:metabolism; D011938:Rec A Recombinases / Q000378:metabolism; D011995:Recombination, Genetic; D014466:Ultraviolet Rays
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D004247:DNA; C066218:recF protein, Bacteria; C078202:UmuC protein, E coli; D011938:Rec A Recombinases; D004259:DNA-Directed DNA Polymerase