Ochratoxin A levels in human plasma and foods in Lebanon.
Ochratoxin A (OTA) is a widespread mycotoxin which contaminates food such as cereals, beer, coffee, wine and products of animal origin. OTA is known for its nephrotoxic, immunotoxic and carcinogenic properties. The prevalence of OTA in human blood and foodstuffs has been investigated in many countries. In this study, exposure of the Lebanese population to OTA was evaluated and the contamination of the most commonly consumed foods in Lebanon by OTA was assessed. Plasma samples from healthy individuals and also cereals and beer samples obtained from markets were collected from the different regions of Lebanon. OTA was detectable in 33% of tested plasma samples (n =250) with a concentration ranging from 0.1 to 0.87 ng/mL and a mean of 0.17+/-0.01ng/mL. No sex and age differences were found. The frequency of OTA-positive plasma samples obtained in the South of Lebanon and in the Bekaa valley (50 and 47%, respectively) was significantly higher compared to plasma samples obtained in the Beirut/Mount Lebanon region (19%). Food analyses showed that wheat, burghul and beer were contaminated with a mean value of 0.15+/-0.03 microg/kg, 0.21+/-0.04 microg/kg and 0.19+/-0.12 ng/mL, respectively. These data suggest that the Lebanese population is exposed to OTA through food ingestion at concentrations lower than the tolerable daily intake.
Assaf
Hind
H
Laboratoire de Toxicologie, Faculté de Pharmacie, Université Saint-Joseph, Beirut, Lebanon.
Betbeder
Anne-Marie
AM
Creppy
Edmond E
EE
Pallardy
Marc
M
Azouri
Hayat
H
D000293:Adolescent; D000328:Adult; D005260:Female; D005504:Food Analysis; D005516:Food Microbiology; D006801:Humans; D007861:Lebanon; D008297:Male; D008875:Middle Aged; D009183:Mycotoxins / Q000097:blood*; D009793:Ochratoxins / Q000097:blood*
D009183:Mycotoxins; D009793:Ochratoxins; C025589:ochratoxin A