Cancer chemotherapy reduces plasma total antioxidant capacity in children with malignancies.
The sum of endogenous and food-derived antioxidants provides an estimate of the total antioxidant capacity (TAC) of the extracellular fluids, while corrected TAC (cTAC) is an estimation of the exogenously provided antioxidants. Similar values for TAC and cTAC were observed between cancer free children and children with malignancy at diagnosis. Antineoplastic treatment induced a significant decrease of TAC and cTAC during chemotherapy. Additionally to the dietary factors, this might be attributed to the antineoplastic drugs as shown by the significant increase of ROS after administration of chemotherapeutic agents both in vitro and in vivo. According to our preliminary results TAC and cTAC returned to normal after the end of therapy.
Papageorgiou
Maria
M
Department of Pediatric Hematology/Oncology, Medical School, University of Crete, P.O. Box 2208, Heraklion, Crete 71003, Greece.
Stiakaki
Eftichia
E
Dimitriou
Helen
H
Malliaraki
Niki
N
Notas
George
G
Castanas
Elias
E
Kalmanti
Maria
M
D000970:Antineoplastic Agents / Q000009:adverse effects*; D000975:Antioxidants / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000737:chemistry; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000097:blood
D000970:Antineoplastic Agents; D000975:Antioxidants; D017382:Reactive Oxygen Species