title: An algorithm for independent verification of Gamma Knife treatment plans.
abstract: A formalism for independent treatment verification has been developed for Gamma Knife radiosurgery in analogy to the second checks being performed routinely in the field of external beam radiotherapy. A verification algorithm is presented, and evaluated based on its agreement with treatment planning calculations for the first 40 Canadian Gamma Knife patients. The algorithm is used to calculate the irradiation time for each shot, and the value of the dose at the maximum dose point in each calculation matrix. Data entry consists of information included on the plan printout, and can be streamlined by using an optional plan import feature. Calculated shot times differed from those generated by the treatment planning software by an average of 0.3%, with a standard deviation of 1.4%. The agreement of dose maxima was comparable with an average of -0.2% and a standard deviation of 1.3%. Consistently accurate comparisons were observed for centrally located lesions treated with a small number of shots. Large discrepancies were almost all associated with dose plans utilizing a large number of collimator plugs, for which the simplifying approximations used by the program are known to break down.
authors.affiliation: CancerCare Manitoba, Winnipeg, Manitoba R3E 0V9, Canada.
authors.forename: James
authors.initials: J
authors.lastname: Beck
authors.forename: Anita
authors.initials: A
authors.lastname: Berndt
mesh_terms: D000465:Algorithms; D001822:Body Burden; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D011785:Quality Assurance, Health Care / Q000379:methods* / Q000592:standards; D011874:Radiometry / Q000379:methods* / Q000592:standards; D016634:Radiosurgery / Q000379:methods* / Q000592:standards; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000592:standards; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D012986:Software Validation