Ephrin-A5 overexpression degrades topographic specificity in the mouse gluteus maximus muscle.
Motor neurons project onto specific muscles with a distinct positional bias. We have previously shown using electrophysiological techniques that overexpression of ephrin-A5 degrades this topographic map. Here, we show that positional differences in axon terminal areas, an entirely different parameter of neuromuscular topography, are also eliminated with ephrin-A5 overexpression. Therefore, we now have both morphological and electrophysiological approaches to explore the mechanisms of neuromuscular topography.
Lampa
S J
SJ
Program in Neuroscience, Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USA.
Potluri
S
S
Norton
A S
AS
Fusco
W
W
Laskowski
M B
MB
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004594:Electrophysiology; D036386:Ephrin-A5 / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D005838:Genotype; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000294:innervation*; D017729:Presynaptic Terminals / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction
D036386:Ephrin-A5