title: A microbial TRP-like polycystic-kidney-disease-related ion channel gene.
abstract: Ion channel genes have been discovered in many microbial organisms. We have investigated a microbial TRP (transient receptor potential) ion channel gene which has most similarity to polycystic-kidney-disease-related ion channel genes. We have shown that this gene (pkd2) is essential for cellular viability, and is involved in cell growth and cell wall synthesis. Expression of this gene increases following damage to the cell wall. This fission yeast pkd2 gene, orthologues of which are found in all eukaryotic cells, appears to be a key signalling component in the regulation of cell shape and cell wall synthesis in yeast through an interaction with a Rho1-GTPase. A model for the mode of action of this Schizosaccharomyces pombe protein in a Ca2+ signalling pathway is hypothesized.
authors.affiliation: Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College, London, South Kensington Campus, London SW7 2AZ, UK. christopher.palmer@ic.ac.uk
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Palmer
authors.forename: Ebru
authors.initials: E
authors.lastname: Aydar
authors.forename: Mustafa B A
authors.initials: MB
authors.lastname: Djamgoz
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D020013:Calcium Signaling / Q000235:genetics; D056850:Cyclin-Dependent Kinase 8; D018844:Cyclin-Dependent Kinases / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D007690:Polycystic Kidney Diseases / Q000235:genetics*; D000091283:Protein Kinase D2; D011494:Protein Kinases / Q000235:genetics; D029702:Schizosaccharomyces pombe Proteins; D017386:Sequence Homology, Amino Acid
chemical_list: D000091283:Protein Kinase D2; D029702:Schizosaccharomyces pombe Proteins; D011494:Protein Kinases; D056850:Cyclin-Dependent Kinase 8; D018844:Cyclin-Dependent Kinases; C112462:srb10 protein, S pombe