title: [The research progress of zebrafish gene engineering].
abstract: The research progress of zebrafish gene engineering is reviewed, in including the recent explosion status of transgenic zebrafish lines, transgeneic zebrafish in targeted screens, the development of transgenic technology in zebrafish as well as the current hotspots and future perspective of zebrafish gene engineering. By now the zebrafish gene engineering, nuclear transplantation and chromosome set manipulation technologies have been established in China. With firm foundation of zebrafish cytogenetics and embryology, we will obtain gene engineering zebrafish with gene targeting integration and promote the advancement and development of biotechnology in applied research field in near future.
authors.affiliation: The Open Laboratory of Marine Functional Genomics of State High-Tech Development, College of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. exwyp@zsu.edu.cn
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Wu
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiong
authors.forename: Guang-Xian
authors.initials: GX
authors.lastname: Zhang
authors.forename: An-Long
authors.initials: AL
authors.lastname: Xu
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D018390:Gene Targeting; D005818:Genetic Engineering; D015027:Zebrafish / Q000235:genetics*