title: Medicinal chemical and pharmacological aspects of imidazole-containing histamine H3 receptor antagonists.
abstract: The first antagonists known for the histamine H3 receptor were mono-substituted imidazole-containing compounds like thioperamide. Meanwhile numerous novel leads have been developed possessing improved affinities, selectivities, specificities, and pharmacokinetic properties. Scope and limitations of this promising class are discussed concerning their structure-activity relationships as well as pharmacological and potential therapeutic aspects.
authors.affiliation: Johann Wolfgang Goethe-Universität, Institut für Pharmazeutische Chemie, Biozentrum, Marie-Curie-Strasse 9, 60439 Frankfurt am Main, Germany. h.stark@pharmchem.uni-frankfurt.de.
authors.forename: Holger
authors.initials: H
authors.lastname: Stark
authors.forename: Markus
authors.initials: M
authors.lastname: Kathmann
authors.forename: Eberhard
authors.initials: E
authors.lastname: Schlicker
authors.forename: Walter
authors.initials: W
authors.lastname: Schunack
authors.forename: Birgit
authors.initials: B
authors.lastname: Schlegel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sippl
mesh_terms: D000818:Animals; D006633:Histamine Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D008024:Ligands; D021281:Quantitative Structure-Activity Relationship; D018100:Receptors, Histamine H3 / Q000737:chemistry / Q000378:metabolism*
chemical_list: D006633:Histamine Antagonists; D007093:Imidazoles; D008024:Ligands; D018100:Receptors, Histamine H3; C029899:imidazole