title: Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients.
abstract: Autologous stem cell transplantation (ASCT) has an established role in the treatment of symptomatic multiple myeloma (MM). Our aim was to analyse the impact of selected prognostic parameters on the survival of patients with MM after ASCT. The new International Staging System (ISS) was also evaluated. A total of 133 MM patients were transplanted in our centre between 1995 and 2002. Following ASCT, 35% of patients were in complete remission (CR) and 60% were in partial remission (PR). The median progression-free (PFS) and overall (OS) survival from transplantation were 29.5 and 68.8 months, respectively. Transplant-related mortality (TRM) was 3%. On multivariate analysis, factors associated with significantly shorter OS were lack of CR after transplant (P = 0.002, hazard ratio (HR): 3.1), stage 3 according to ISS (P = 0.001, HR: 3.0) and age at transplant over 60 years (P = 0.035, HR: 2.0). The status of disease before ASCT did not significantly affect PFS and OS after transplantation. We conclude that ASCT is a safe and effective procedure in MM patients, associated with low TRM. The survival after ASCT was dependent on response after ASCT, stage according to ISS and age.
authors.affiliation: Department of Internal Medicine - Haematooncology, Masaryk University Hospital, Jihlavska 20, Brno 625 00, Czech Republic. mkrejci@fnbrno.cz
authors.forename: M
authors.initials: M
authors.lastname: Krejci
authors.forename: T
authors.initials: T
authors.lastname: Buchler
authors.forename: R
authors.initials: R
authors.lastname: Hajek
authors.forename: A
authors.initials: A
authors.lastname: Svobodnik
authors.forename: A
authors.initials: A
authors.lastname: Krivanova
authors.forename: L
authors.initials: L
authors.lastname: Pour
authors.forename: Z
authors.initials: Z
authors.lastname: Adam
authors.forename: J
authors.initials: J
authors.lastname: Mayer
authors.forename: J
authors.initials: J
authors.lastname: Vorlicek
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014182:Transplantation, Autologous