title: [MTX/CDDP/5-FU double modulation intra-peritoneal chemotherapy for advanced and metastatic gastric cancer--comparison with intra-aortic route and intra-venous route].
abstract: We studied the efficacy of MTX/CDDP/5-FU intra-peritoneal chemotherapy for advanced and metastatic gastric cancer (n=24), and compared the results with intra-aortic (n=26) and intra-venous (n=21) routes of MTX-CDDP-5-FU double modulation therapy. I.p. administration was more efficient for reduction of malignant acites (p=0.049). However, median survival duration of malignant acites cases showed no difference between the i.p. group and i.a., i.v. groups (p=0.103). Survival rate of the i.p. group was no different with those of i.a. and i.v. groups (p=0.36). Frequency of side effects is much lower in the i.p. group.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Ohkubo Hospital.
authors.forename: Michio
authors.initials: M
authors.lastname: Maruyama
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ebuchi
authors.forename: Kaku
authors.initials: K
authors.lastname: Takashima
authors.forename: Shoji
authors.initials: S
authors.lastname: Maruyama
authors.forename: Kumi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Masahide
authors.initials: M
authors.lastname: Ohbe
authors.forename: Ayaki
authors.initials: A
authors.lastname: Koide
authors.forename: You
authors.initials: Y
authors.lastname: Shinoura
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Katoh
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral / Q000009:adverse effects; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality
chemical_list: D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate