title: Nerve conduction study in Sydenham's chorea.
abstract: Sydenham's chorea (SC) is a late complication of group A beta-hemolytic streptococci infection presumably caused by an abnormal autoimmune reaction. Despite rare case reports of peripheral neuropathy associated with streptococcal infection, there is no investigation of peripheral nerve in SC. We performed nerve conduction studies in a cohort of patients with SC. The neurophysiology investigation comprised measurement of amplitude and sensory conduction velocity of median, ulnar, and sural nerves; amplitude and motor conduction velocity; and F-wave latency of median, ulnar, fibular, and tibial nerves. Twenty-six patients entered the study (12 females, 14 males; mean age 12.8 +/- 3.6 years). Thirteen subjects had absent or decreased deep reflexes. All investigated neurophysiological parameters fell within the normal range for our population. We failed to find neurophysiological evidence of peripheral nerve involvement in patients with a history of SC. Our findings suggest that the possible autoimmune dysfunction in SC patients is not targeted against epitopes present in peripheral nerves.
authors.affiliation: Movement Disorders Clinic, Department of Psychiatry and Neurology, The Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. cardosofe@terra.com.br
authors.forename: Francisco
authors.initials: F
authors.lastname: Cardoso
authors.forename: Leonardo
authors.initials: L
authors.lastname: Dornas
authors.forename: Mauro
authors.initials: M
authors.lastname: Cunningham
authors.forename: José Teotonio
authors.initials: JT
authors.lastname: Oliveira
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D001426:Bacterial Proteins; D002648:Child; D002819:Chorea / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D004576:Electromyography / Q000295:instrumentation; D005260:Female; D006460:Hemolysin Proteins; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology*; D010543:Peroneal Nerve / Q000503:physiopathology; D013290:Streptococcal Infections / Q000150:complications; D013497:Sural Nerve / Q000503:physiopathology; D013979:Tibial Nerve / Q000503:physiopathology; D014459:Ulnar Nerve / Q000503:physiopathology
chemical_list: D001323:Autoantibodies; D001426:Bacterial Proteins; D006460:Hemolysin Proteins; C071495:streptococcal group B hemolysin