Effects of a single dose of dexamethasone-21-isonicotinate on the metabolism of heifers in early lactation.
Eight Swedish crossbred heifers, about two-and-a-half years old, were given a single intramuscular dose of dexamethasone-21-isonicotinate between nine and 15 days after they had calved and eight similar heifers were left untreated. The treatment had no significant effects on the lipolytic activity of the heifers' fat tissues, and no effect on the concentrations of non-esterified fatty acids and beta-hydroxybutyrate in blood or the triacylglycerol content of the liver. However, there were significant increases in plasma glucose concentrations two days after the injection and in plasma insulin concentrations two and four days after the injection.
Jorritsma
R
R
Department of Farm Animal Health, Faculty of Veterinary Medicine, Yalelaan 7, Utrecht, The Netherlands.
Thanasak
J
J
Houweling
M
M
Noordhuizen
J P T M
JP
Müller
K E
KE
D020155:3-Hydroxybutyric Acid / Q000097:blood; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002417:Cattle / Q000378:metabolism*; D003908:Dexamethasone Isonicotinate / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007774:Lactation / Q000378:metabolism*; D008066:Lipolysis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects; D005723:gamma-Glutamyltransferase / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005938:Glucocorticoids; D007328:Insulin; D003908:Dexamethasone Isonicotinate; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D020155:3-Hydroxybutyric Acid