title: Toward the total synthesis of phorboxazole B: an efficient synthesis of the C20-C46 segment.
abstract: An efficient synthesis of the C20-C46 segment of phorboxazole B is described. The key steps involved Hg(OAc)(2)/I(2)-induced cyclization to construct the cis-tetrahydropyran moiety, the coupling of the metalated 2-methyloxazole 7 with lactone 6, and Julia olefination to furnish the conjugated diene moiety.
authors.affiliation: Shanghai Institute of Organic Chemistry, 354 Fenglin Rd, Shanghai 200032, P.R. China.
authors.forename: De Run
authors.initials: DR
authors.lastname: Li
authors.forename: Cai Yun
authors.initials: CY
authors.lastname: Sun
authors.forename: Ce
authors.initials: C
authors.lastname: Su
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lin
authors.forename: Wei-Shan
authors.initials: WS
authors.lastname: Zhou
mesh_terms: D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D010080:Oxazoles; C408887:phorboxazole A