title: How can we further improve radiotherapy for stage-III non-small-cell lung cancer?
abstract: Combined modality treatment in advanced NSCLC has produced some gain in treatment outcome. Local control as addressed by radiotherapy is still a significant site of failure. Doses higher than achieved by conventional conformal radiotherapy are shown to result in better control rates. Volume restriction seems to be the most important issue in dose escalation. Integration of PET imaging into target definition, omission of clinically uninvolved lymph-node areas and measures to decrease set-up and movement uncertainties are explored. Introduction of risk estimation based on dose-volume analysis for dose prescription may further optimise individual treatment.
authors.affiliation: Dept. of Radiation Oncology, Klinik und Poliklinik für Strahlentherapie, Julius-Maximilians-University Würzburg, Josef-Schneider-Str. 11, D-97080 Wüirzburg, Germany. beckmann_g@klinik.uni-wuerzburg.de
authors.forename: Gabriele K
authors.initials: GK
authors.lastname: Beckmann
authors.forename: Oliver
authors.initials: O
authors.lastname: Kölbl
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieger
authors.forename: Jörn
authors.initials: J
authors.lastname: Wulf
authors.forename: Michael P
authors.initials: MP
authors.lastname: Flentje
mesh_terms: D000465:Algorithms; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal