title: Treatment of seasonal affective disorder: unipolar versus bipolar differences.
abstract: Evidence-based treatments for seasonal affective disorder (SAD) include light therapy and pharmacotherapy. We briefly review the diagnosis and treatment of SAD, focusing on clinical and treatment differences between patients with unipolar and bipolar illness. Special considerations for the management of SAD in patients with bipolar disorder are discussed, including the need to monitor for emergence of manic and hypomanic mood switches, to use mood stabilizers in patients with bipolar I disorder, and to be aware of potential interactions between bright light and medications used in treating bipolar disorder. Chronobiological treatments such as bright light therapy may be combined with pharmacotherapy to enhance therapeutic effects, reduce adverse side effects, and optimize treatment in patients with seasonal and nonseasonal bipolar disorder.
authors.affiliation: Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1.
authors.forename: Chang-Ho
authors.initials: CH
authors.lastname: Sohn
authors.forename: Raymond W
authors.initials: RW
authors.lastname: Lam
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000523:psychology / Q000628:therapy; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy; D006801:Humans; D010789:Phototherapy; D011379:Prognosis; D016574:Seasonal Affective Disorder / Q000523:psychology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents