title: [Clinical course of the ventilatory function in COPD: analytical study of 160 cases].
abstract: The incidence of chronic obstructive pulmonary disease (COPD) is increasing particularly in developing countries. Their prognosis depend on several factors in particular the one second forced expiratory volume (FEV1) decline. To study FEV1 decline speed and factors affecting it, we carried out a retrospective study of 160 cases of COPD in stable state and heaving at least two FEV1 measures at 6 months of interval in the minimum and. The middle age was 63 +/- 12 yr, 52% was former smokers and 46% current smokers, with middle of 50 +/- 27 pack-yr. The FEV1 decline was calculated by linear regression models. The decline average in FEV1 with time was 72 +/- 55 ml/yr. Absolute value was higher than 30 ml/yr therefore more accelerated than general population in 79% of cases. We confirmed by multivariate analysis that age and smoking habit and increased the FEV1 decline. However this last correlated with FEV1% predicted. We concluded that the decline of FEV1 is higher in COPD that in the general population and slowing it needs smoking stop.
authors.affiliation: Service de Pneumologie et d'Allergologie, CHU F. Bourguiba Monastir.
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Battikh
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Ben Sayah
authors.forename: Sameh
authors.initials: S
authors.lastname: Joobeur
authors.forename: Raja
authors.initials: R
authors.lastname: Naouar
authors.forename: Anis
authors.initials: A
authors.lastname: Maatallah
authors.forename: Naceur
authors.initials: N
authors.lastname: Rouatbi
authors.forename: Kamel
authors.initials: K
authors.lastname: Ben Salem
authors.forename: Ali
authors.initials: A
authors.lastname: El Kamel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012123:Pulmonary Ventilation; D012189:Retrospective Studies