Receptor trafficking and synaptic plasticity.
Long-term potentiation and long-term depression are processes that have been widely studied to understand the molecular basis of information storage in the brain. Glutamate receptors are required for the induction and expression of these forms of plasticity, and GABA (gamma-aminobutyric acid) receptors are involved in their modulation. Recent insights into how these receptors are rapidly moved into and out of synaptic membranes has profound implications for our understanding of the mechanisms of long-term potentiation and long-term depression.
Collingridge
Graham L
GL
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK. g.l.collingridge@bris.ac.uk
Isaac
John T R
JT
Wang
Yu Tian
YT
D000818:Animals; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology*; D018079:Receptors, GABA / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D013569:Synapses / Q000235:genetics / Q000378:metabolism*
D018079:Receptors, GABA; D017470:Receptors, Glutamate