title: A pilot study on the efficacy of ketorolac plus tramadol infusion combined with erythrocytapheresis in the management of acute severe vaso-occlusive crises and sickle cell pain.
abstract: One of the major causes of hospitalization for patients with sickle cell disease (SCD) are vaso-occlusive crises (VOC), which are characterized by acute pain and organ damage related to the presence of dense red cells. Here we report a pilot study which combined balanced analgesia with tramadol plus ketorolac and erythrocytapheresis. Key words: sickle cell disease, therapeutic erythrocytapheresis, HbS, visual analog scale, vaso-occlusive crisis.
authors.forename: Lucia
authors.initials: L
authors.lastname: de Franceschi
authors.forename: Gabriele
authors.initials: G
authors.lastname: Finco
authors.forename: Aurora
authors.initials: A
authors.lastname: Vassanelli
authors.forename: Barbara
authors.initials: B
authors.lastname: Zaia
authors.forename: Stefano
authors.initials: S
authors.lastname: Ischia
authors.forename: Roberto
authors.initials: R
authors.lastname: Corrocher
mesh_terms: D000293:Adolescent; D000700:Analgesics / Q000627:therapeutic use*; D000755:Anemia, Sickle Cell / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016238:Cytapheresis; D017707:Erythrocyte Transfusion / Q000379:methods*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D020910:Ketorolac / Q000627:therapeutic use*; D008297:Male; D010146:Pain / Q000209:etiology; D059408:Pain Management; D010865:Pilot Projects; D014147:Tramadol / Q000627:therapeutic use*; D014652:Vascular Diseases / Q000209:etiology / Q000503:physiopathology*
chemical_list: D000700:Analgesics; D014147:Tramadol; D020910:Ketorolac