title: Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1).
abstract: Ring-oxidized retinoids have been synthesized stereoselectively using the Stille cross-coupling reaction. Kinetic constants of mouse class I alcohol dehydrogenase (ADH1) with these retinoids were determined.
authors.affiliation: Departamento de Química Orgánica, Universidade de Vigo, 36200 Vigo, Spain. qolera@usc.es
authors.forename: Marta
authors.initials: M
authors.lastname: Domínguez
authors.forename: Rosana
authors.initials: R
authors.lastname: Alvarez
authors.forename: Sílvia
authors.initials: S
authors.lastname: Martras
authors.forename: Jaume
authors.initials: J
authors.lastname: Farrés
authors.forename: Xavier
authors.initials: X
authors.lastname: Parés
authors.forename: Angel R
authors.initials: AR
authors.lastname: de Lera
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D001671:Biochemistry / Q000379:methods*; D004224:Diterpenes; D007700:Kinetics; D051379:Mice; D010084:Oxidation-Reduction; D012172:Retinaldehyde / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D012176:Retinoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014801:Vitamin A / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
chemical_list: C496908:4-hydroxy-retinol; D004224:Diterpenes; D012176:Retinoids; D014801:Vitamin A; C099660:4-oxoretinaldehyde; D000426:Alcohol Dehydrogenase; D012172:Retinaldehyde