title: Acute dysautonomia: complete recovery after two courses of IVIg.
abstract: An 11-year-old boy presented with acute dysautonomia manifesting as severe orthostatic hypotension following fever. Serial orthostatic tests with measurement of the coefficient of variation in the R-R intervals showed improvement after one course and complete recovery after two courses of intravenous high-dose immunoglobulin therapy (IVIg). Repeated courses of IVIg should be considered to treat this disorder if spontaneous remission does not occur.
authors.affiliation: Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. mamiko@ped.med.tohoku.ac.jp
authors.forename: Mamiko
authors.initials: M
authors.lastname: Ishitobi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Haginoya
authors.forename: Taro
authors.initials: T
authors.lastname: Kitamura
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Munakata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Kazuie
authors.initials: K
authors.lastname: Iinuma
mesh_terms: D020274:Autoimmune Diseases of the Nervous System / Q000188:drug therapy* / Q000276:immunology* / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy* / Q000276:immunology* / Q000503:physiopathology; D002648:Child; D004334:Drug Administration Schedule; D005334:Fever / Q000150:complications; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D020127:Recovery of Function / Q000187:drug effects* / Q000276:immunology; D013610:Tachycardia / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous