title: Second- and third-trimester therapeutic terminations of pregnancy in cases with complete placenta previa--does feticide decrease postdelivery maternal hemorrhage?
abstract: OBJECTIVE
  To study the feasibility of second- and third-trimester termination of pregnancy (TOP) with complete placenta previa, and the impact of performing feticide before labor induction on maternal hemorrhagic morbidity.
  
  
  METHODS
  From 1987 to 2002, the databases of two referral hospitals were reviewed. We identified 15 cases of second- or third-trimester TOP in women with complete placenta previa. Feticide was performed 2-14 days before induction in 6/15 cases. Cervical ripening was achieved in 8 cases by mifepristone alone (n = 2) or by mifepristone and dilapan (n = 6). Labor was induced by vaginal gemeprost (n = 2), intramuscular (n = 5) or intravenous (n = 4) sulprostone, vaginal misoprostol (n = 1) or a combination of misoprostol and sulprostone (n = 3). Hemorrhage was defined by the need for transfusion. The difference between the preoperative and the lowest per- or postoperative maternal hemoglobin level was also analyzed.
  
  
  RESULTS
  Of the 9 women who underwent labor induction without previous feticide, 4 required blood transfusions, 1 of whom had a hemostat hysterectomy. The mean hemoglobin difference was 2.5 g/dl (range: 0.5-5.3). None of the 6 patients with preinduction feticide required transfusion. The hemoglobin difference was significantly smaller in this group than in terminations without previous feticide (mean: 1.0 g/dl ; range: 0.1-2.2; p = 0.03).
  
  
  CONCLUSIONS
  In cases with complete placenta previa, second- or third-trimester TOP is feasible. It carries a substantial risk of hemorrhage that might be decreased by preinduction feticide.
authors.affiliation: Maternité, Hôpital Necker Enfants Malades, AP-HP et Université Paris V, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Ruano
authors.forename: Y
authors.initials: Y
authors.lastname: Dumez
authors.forename: D
authors.initials: D
authors.lastname: Cabrol
authors.forename: M
authors.initials: M
authors.lastname: Dommergues
mesh_terms: D000032:Abortion, Therapeutic / Q000379:methods*; D001803:Blood Transfusion; D005260:Female; D006454:Hemoglobins; D006801:Humans; D007743:Labor, Obstetric; D010923:Placenta Previa / Q000401:mortality / Q000628:therapy*; D006473:Postpartum Hemorrhage / Q000401:mortality / Q000517:prevention & control*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012307:Risk Factors
chemical_list: D006454:Hemoglobins