title: Health-related quality of life at age 10 years in very low-birth-weight children with and without threshold retinopathy of prematurity.
abstract: OBJECTIVE
  To describe parental perspectives on health status and health-related quality of life (HRQL) at age 10 years in children with birth weights less than 1251 g who participated in the multicenter Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) study.
  
  
  METHODS
  In 244 participants in the randomized CRYO-ROP trial and 102 CRYO-ROP participants who did not develop ROP, the Health Utilities Index (HUI) system was used to characterize health status for the following 8 attributes: vision, hearing, speech, ambulation, dexterity, emotion, cognition, and pain. Using a utility formula, HRQL was determined for each child on a scale from 0.0 (dead) to 1.00 (perfect health).
  
  
  RESULTS
  The proportion of the ROP-randomized group with limitations in 4 attributes or more was 20.6% compared with 2.0% for the no-ROP group. Within the ROP-randomized group, the proportion of "sighted" children with limitations in 4 attributes or more was 6.4% vs 46.5% in the "blind/low vision" group. The median HRQL score for the ROP-randomized children was lower than for the no-ROP children (0.72 vs 0.97, P<.001); the median HRQL score for the sighted-randomized children was 0.87 vs 0.27 for the blind/low vision children (P<.001).
  
  
  CONCLUSIONS
  Threshold ROP was associated with functional limitations in health attributes and reduction in HRQL scores at age 10 years. Furthermore, among children who developed threshold ROP, a greater reduction in HRQL scores was found among children with a poor visual outcome compared with those with better sight.
authors.affiliation: Division of Pediatric Ophthalmology, The Children's Hopsital of Philadelphia, PA 19104, USA. quinn@email.chop.edu
authors.forename: Graham E
authors.initials: GE
authors.lastname: Quinn
authors.forename: Velma
authors.initials: V
authors.lastname: Dobson
authors.forename: Saroj
authors.initials: S
authors.lastname: Saigal
authors.forename: Dale L
authors.initials: DL
authors.lastname: Phelps
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hardy
authors.forename: Betty
authors.initials: B
authors.lastname: Tung
authors.forename: C Gail
authors.initials: CG
authors.lastname: Summers
authors.forename: Earl A
authors.initials: EA
authors.lastname: Palmer
mesh_terms: D000203:Activities of Daily Living; D001294:Attitude to Health; D002648:Child; D017679:Cryotherapy; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000523:psychology*; D008297:Male; D015337:Multicenter Studies as Topic; D010290:Parents / Q000523:psychology*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012178:Retinopathy of Prematurity / Q000523:psychology* / Q000601:surgery; D014786:Vision Disorders / Q000523:psychology*