title: A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population.
abstract: To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals. The frequency of the 77G allele in the control group was 1.1%, which was not significantly different from the 1.2% found in the patient group (P = 0.922). The C to G transversion does not seem to be associated with susceptibility for T1D.
authors.affiliation: Institute for Transfusion Medicine, University of Jena, Jena, Germany. hansjoerg.thude@med.uni-jena.de
authors.forename: H
authors.initials: H
authors.lastname: Thude
authors.forename: S
authors.initials: S
authors.lastname: Rosenhahn
authors.forename: W
authors.initials: W
authors.lastname: Hunger-Dathe
authors.forename: U-A
authors.initials: UA
authors.lastname: Müller
authors.forename: D
authors.initials: D
authors.lastname: Barz
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005091:Exons; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics* / Q000276:immunology; D017354:Point Mutation; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017422:Sequence Analysis, DNA
chemical_list: D017493:Leukocyte Common Antigens; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1