title: Potential anti-atherogenic cell action of the naturally occurring 4-O-methyl derivative of gallic acid on Ang II-treated macrophages.
abstract: We have recently established that the blood concentrations of gallic acid (GA), a polyphenolic component naturally found in food, and its O-methyl derivatives are very low (practically < or = 1 microM) in physiological (postprandial) condition. Using acellular oxidant systems and macrophage-differentiated promonocytes (MDPs) THP-1, we show here that the direct and indirect (through depressing effect on the superoxide cell production) antioxidant properties of these components were not effective at these concentrations. In contrast, 4-O-methyl GA was the most efficient component to depress AT1R and CD36 mRNA expression in Ang II-treated MDPs, suggesting a strong inhibition of Ang II-triggered pro-atherogenic mechanisms of foam cell formation.
authors.affiliation: Laboratoire de Nutrition Humaine et Athérogénèse, EA 2993, Institut de Biologie, Université Montpellier I, Montpellier, France.
authors.forename: Maria V Bizerra
authors.initials: MV
authors.lastname: Oliveira
authors.forename: Eric
authors.initials: E
authors.lastname: Badia
authors.forename: Marie-Annette
authors.initials: MA
authors.lastname: Carbonneau
authors.forename: Paul
authors.initials: P
authors.lastname: Grimaldi
authors.forename: Gilles
authors.initials: G
authors.lastname: Fouret
authors.forename: Celine
authors.initials: C
authors.lastname: Lauret
authors.forename: Claude L
authors.initials: CL
authors.lastname: Léger
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000517:prevention & control*; D001483:Base Sequence; D018955:CD36 Antigens / Q000235:genetics; D002460:Cell Line; D017931:DNA Primers; D005707:Gallic Acid / Q000494:pharmacology*; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000235:genetics; D013481:Superoxides / Q000378:metabolism
chemical_list: D018955:CD36 Antigens; D017931:DNA Primers; D012333:RNA, Messenger; D011945:Receptors, Angiotensin; D013481:Superoxides; D000804:Angiotensin II; D005707:Gallic Acid