Recent insights into the structure and mechanism of the sodium pump.
The sodium pump (or Na-K-ATPase) is essential to the function of animal cells. Publication of the related calcium pump (SERCA) structure together with several recent results from a variety of approaches allow us to propose a mechanistic model to answer the question: "How does the sodium pump pump?"
Horisberger
J-D
JD
Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland. jean-daniel.horisberger@ipharm.unil.ch
D000818:Animals; D006801:Humans; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
D000254:Sodium-Potassium-Exchanging ATPase