title: Ribosomal RNA processing and ribosome biogenesis in eukaryotes.
abstract: In eukaryotes nearly 500 rRNAs, ribosomal proteins, snoRNAs and trans-acting factors contribute to ribosome biogenesis. After more than 30 years of intense research, the incredible complexities of nucleolar function are revealed but details often remain unclear. Here we review this progress and the many intriguing questions which remain.
authors.affiliation: Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario, Canada. rnnazar@uoguelph.ca
authors.forename: Ross N
authors.initials: RN
authors.lastname: Nazar
mesh_terms: D021581:Active Transport, Cell Nucleus; D002466:Cell Nucleolus / Q000378:metabolism*; D004252:DNA Mutational Analysis; D005057:Eukaryotic Cells / Q000378:metabolism*; D008954:Models, Biological; D008957:Models, Genetic; D012323:RNA Processing, Post-Transcriptional; D012331:RNA, Fungal; D012335:RNA, Ribosomal / Q000378:metabolism*; D020537:RNA, Small Nucleolar / Q000737:chemistry*; D012270:Ribosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012568:Schizosaccharomyces / Q000378:metabolism
chemical_list: D012331:RNA, Fungal; D012335:RNA, Ribosomal; D020537:RNA, Small Nucleolar