Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction.
This study evaluated left ventricular diastolic function with Doppler echocardiography before and after statin therapy. Statin therapy worsened diastolic parameters in most patients; coenzyme Q(10) supplementation in patients with worsening diastolic function with statin therapy improved parameters of diastolic function.
Silver
Marc A
MA
Heart Failure Institute, Department of Medicine, Advocate Christ Medical Center, University of Illinois/Christ Cardiovascular Disease Fellowship Program, Oak Lawn, Illinois 60453, USA. marc.silver@advocatehealth.com <marc.silver@advocatehealth.com>
Langsjoen
Peter H
PH
Szabo
Szabolcs
S
Patil
Harish
H
Zelinger
Allan
A
D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D000069059:Atorvastatin; D003067:Coenzymes; D015150:Echocardiography, Doppler; D005260:Female; D006538:Heptanoic Acids / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000009:adverse effects / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects*
D000924:Anticholesteremic Agents; D000975:Antioxidants; D003067:Coenzymes; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D014451:Ubiquinone; D000069059:Atorvastatin; C024989:coenzyme Q10