Serum levels of soluble intercellular adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1 in Alzheimer's disease.
Serum soluble intercellular adhesion molecule-1 (s-ICAM-1) and soluble E-selectin (s-ELAM-1) were evaluated in 25 patients with Alzheimer's disease (AD), 54 patients with noninflammatory neurological diseases (NIND), and 15 control subjects. Patients with AD had a higher s-ICAM-1 level compared with the NIND patients and the control subjects (P< .001 and P< .04, respectively). The presence of high s-ICAM-1 values may be related to immunological processes involved in pathogenetic mechanisms of AD. The not statistically significant values of (s-ELAM-1), a glycoprotein considered an exclusive marker of endothelial activation, compared with the NIND patients and healthy subjects (P< .47 and P< .17, respectively), seem to suggest the neural rather than the endothelial s-ICAM origin in patients with AD.
Rentzos
M
M
Department of Neurology, Aeginition Hospital, Athens Medical School, Vass. Sophias av. 72-74, 11528 Athens, Greece. mrentzos@med.uoa.gr.
Michalopoulou
M
M
Nikolaou
C
C
Cambouri
C
C
Rombos
A
A
Dimitrakopoulos
A
A
Kapaki
E
E
Vassilopoulos
D
D
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012720:Severity of Illness Index
D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1