title: Comparison of perfusion computed tomography with diffusion-weighted magnetic resonance imaging in hyperacute ischemic stroke.
abstract: OBJECTIVE
  In this study, perfusion CT and diffusion-weighted magnetic resonance imaging (DWI) were compared as means of assessing the ischemic brain in hyperacute stroke.
  
  
  METHODS
  Twenty patients with ischemic stroke underwent perfusion computed tomography (CT) and magnetic resonance imaging (MRI) studies <3 hours after stroke onset. Cerebral blood flow thresholds were used to delineate the ischemic lesion, penumbra, and infarct. Correlations between the volume of the hypoperfused areas, the abnormality volume in admission DWI and follow-up CT/MRI studies, and the clinical National Institutes of Health Stroke Scale (NIHSS) scores were performed.
  
  
  RESULTS
  The volume of the ischemic (core and penumbra) lesion on admission perfusion CT was correlated with the volume of admission DWI abnormalities (r=0.89, P=0.001). The infarcted core tissue volume (on admission CT) correlated more strongly (r=0.77, P=0.0001) than the admission DWI abnormality volume (r=0.69, P=0.002) with the follow-up infarct volume on fluid-attenuated inversion recovery images. A correlation was demonstrated between infarct volume in perfusion CT and follow-up DWI abnormality volume (r=0.89, r=0.77, P=0.002). Significant correlations were found between ischemic and infarct region volumes in perfusion CT and NIHSS admission and follow-up scores (P < or = 0.01).
  
  
  CONCLUSIONS
  Both imaging modalities provide a sufficient assessment of the hyperacute brain infarct, with significant correlation between them and the clinical condition at admission. Perfusion CT allows differentiation of the penumbra and infarct core region with significant predictive value of follow-up infarct volume and clinical outcome.
authors.affiliation: Department of Neuroradiology, Hannover Medical School, Hannover, Germany. sbidas@yahoo.com
authors.forename: Sotirios
authors.initials: S
authors.lastname: Bisdas
authors.forename: Frank
authors.initials: F
authors.lastname: Donnerstag
authors.forename: Bjorn
authors.initials: B
authors.lastname: Ahl
authors.forename: Ina
authors.initials: I
authors.lastname: Bohrer
authors.forename: Karin
authors.initials: K
authors.lastname: Weissenborn
authors.forename: Hartmut
authors.initials: H
authors.lastname: Becker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D002545:Brain Ischemia / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000175:diagnosis / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use; D010343:Patient Admission; D011237:Predictive Value of Tests; D011856:Radiographic Image Enhancement; D020521:Stroke / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents