Effectiveness of propagermanium treatment in multiple myeloma patients.
Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the condition of four patients was stable (stable disease, SD). After discontinuation of propagermanium, the status of MM progressed in two patients who were in SD and in two patients who had achieved PR. The administration of propagermanium was restarted in one patient resulting in a decrease in her paraprotein.
Tsutsumi
Yutaka
Y
Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan. rtsutsu@nyc.odn.ne.jp
Tanaka
Junji
J
Kanamori
Hiroe
H
Musashi
Mio
M
Minami
Hiina
H
Fukushima
Arata
A
Yamato
Hiroaki
H
Ehira
Nobuyuki
N
Kawamura
Takahito
T
Obara
Shinji
S
Ogura
Nobutaka
N
Asaka
Masahiro
M
Imamura
Masahiro
M
Masauzi
Nobuo
N
D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005857:Germanium; D006801:Humans; D007369:Interferon Inducers / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D009194:Myeloma Proteins / Q000032:analysis; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011422:Propionates; D012074:Remission Induction; D016896:Treatment Outcome
D007369:Interferon Inducers; D009194:Myeloma Proteins; D009942:Organometallic Compounds; D011422:Propionates; D005857:Germanium; C066750:propagermanium