Effects of impaired fasting glucose and impaired glucose tolerance on predicting incident type 2 diabetes in a Chinese population with high post-prandial glucose.
OBJECTIVE
To ascertain which impaired glucose homeostasis at baseline is predictive of conversion to type 2 diabetes in both men and women in a high-risk non-diabetic population.


METHODS
The screening survey for type 2 diabetes was conducted in 1994, and a follow-up study of 627 high-risk non-diabetic individuals at baseline was carried out in 1999 in Beijing area. A total of 70 men and 76 women developed diabetes during the 5-year follow-up.


RESULTS
After adjustment for age, body mass index, smoking, systolic blood pressure, family history of diabetes, total cholesterol, triglycerides, antihypertensive medication, occupation, education, urine albumin excretion rate, and fasting insulin, the odds ratios for incidence of diabetes were 1.00, 2.04 (95% CI 0.84-4.97), 7.82 (2.66-23.00), 9.38 (3.30-26.69) in men with normal glucose, isolated IFG, isolated IGT, and both IFG and IGT, respectively. In women, the corresponding odds ratios were 1.00, 2.19 (0.91-5.30), 1.62 (0.72-3.67), and 8.79 (2.98-25.93), respectively.


CONCLUSIONS
This study shows that combined IFG and IGT at baseline is a strong risk predictor for the development of diabetes in both men and women. Isolated IGT is also a predictor of diabetes in Chinese men.
Wang
Jian-Jun
JJ
Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Kytosuontie 11, KTL/GE-Lab, FIN-00300 Helsinki, Finland. jianjun.wang@ktl.fi
Yuan
Shen-Yuan
SY
Zhu
Liang-Xiang
LX
Fu
Han-Jing
HJ
Li
Hong-Bing
HB
Hu
Gang
G
Tuomilehto
Jaakko
J
D044466:Asian People; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology*; D005215:Fasting / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D016017:Odds Ratio; D019518:Postprandial Period; D011237:Predictive Value of Tests; D012307:Risk Factors
D001786:Blood Glucose