title: Cellular distribution and functions of P2 receptor subtypes in different systems.
abstract: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body. Each section provides an account of the early history of purinergic signaling in the organ?cell up to 1994, then summarizes subsequent evidence for the presence of P2X and P2Y receptor subtype mRNA and proteins as well as functional data, all fully referenced. A section is included describing the plasticity of expression of P2 receptors during development and aging as well as in various pathophysiological conditions. Finally, there is some discussion of possible future developments in the purinergic signaling field.
authors.affiliation: Autonomic Neuroscience Institute, Royal Free and University College Medical School, London NW3 2PF, United Kingdom.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Burnstock
authors.forename: Gillian E
authors.initials: GE
authors.lastname: Knight
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000235:genetics*; D002490:Central Nervous System / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000235:genetics* / Q000378:metabolism*; D058469:Receptors, Purinergic P2X; D058472:Receptors, Purinergic P2Y1; D015398:Signal Transduction / Q000235:genetics*; D014781:Viscera / Q000378:metabolism*
chemical_list: C546382:P2RY1 protein, human; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; D058472:Receptors, Purinergic P2Y1