title: The use of haloperidol and associated complications in the agitated, acutely ill pediatric burn patient.
abstract: The use of haloperidol to induce sedation and control agitation in the acutely ill adult patient has been well documented. There are few reports, however, of the use of this neuroleptic agent to control the severe delirium and agitation that may occur in critically ill pediatric patients or acute pediatric patients suffering from burn wounds. We assessed the effectiveness and safety of the use of haloperidol by completing a retrospective chart review of 855 acutely ill children treated consecutively during the period from April 1999 to May 2002, during which time 26 children received haloperidol. The safe use of haloperidol was assessed by documenting any adverse effects or reactions observed after the administration of the drug. Of patients given haloperidol, 23% had adverse effects. This result suggests that the use of haloperidol to treat the acutely agitated and delirious pediatric burn patients is fraught with a number of difficulties and is not completely safe and effective.
authors.affiliation: Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Ratcliff
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Meyer
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Cuervo
authors.forename: Cynthia
authors.initials: C
authors.lastname: Villarreal
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Thomas
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D000293:Adolescent; D018726:Anti-Dyskinesia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002056:Burns / Q000150:complications*; D002648:Child; D016638:Critical Illness; D003693:Delirium / Q000188:drug therapy* / Q000209:etiology; D004421:Dystonia / Q000139:chemically induced; D005260:Female; D005334:Fever / Q000139:chemically induced; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000209:etiology; D012189:Retrospective Studies
chemical_list: D018726:Anti-Dyskinesia Agents; D006220:Haloperidol