[Remodeling of elastic arteries in patients with hypertensive disease: diagnostic value of pulse pressure].
The study was undertaken to examine a role of pulse blood pressure (PBP) as a diagnostic marker of remodeling of large elastic arteries in patients with hypertensive disease (HD). A hundred and sixty-eight patients with HD and 38 apparently healthy individuals (a control group) were examined. In all the examinees, PBP was measured and central PBP (PBPc) was calculated. According to the value of PBPc, the patients with HD were divided into 4 groups: 1) PBPc was equal or less than 45 mm Hg; 2) that was 46-50 mm Hg; 3) PBPc was 51-64 mm Hg; and 4) that was equal or more than 65 mm Hg. With Doppler study, the aortic pulse wave propagation velocity (PWPV) was determined and the aortic stiffness coefficient was (C). Seventy-seven patients with HD and 20 control individuals underwent magnetic resonance imaging with the aortic intraluminal diameter (D(ao)) and wall thickness (H(ao)) being estimated. As compared with the controls, patients with HD were found to have significantly increased PWPV, C(s), D(ao), and H(ao) which characterizes elastic arterial remodeling in HD. Comparison of these parameters in persons with different levels of PBPc demonstrated progressive dilatation, the increased stiffness and enlarged thickness of the wall of elastic arteries in those having higher PBPc. The results of a regression analysis confirmed that there is a significant relationship of PBPc with C(s), D(ao), and H(ao) and the coefficients of correlation between were 0.89, 0.71, and 0.75, respectively. The findings have indicated that the level of PBPc may serve as a marker of remodeling of large elastic arteries in patients with HD.
Polivoda
S N
SN
Cherepok
A A
AA
Sychev
R A
RA
D000368:Aged; D001158:Arteries / Q000473:pathology / Q000503:physiopathology*; D001794:Blood Pressure; D001795:Blood Pressure Determination; D004548:Elasticity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D017078:Laser-Doppler Flowmetry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011673:Pulsatile Flow; D011674:Pulse; D012044:Regression Analysis