[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2002). III. Secular changes in susceptibility].
The bacteria (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella spp. and Pseudomonas aeruginosa) isolated from patients diagnosed as urinary tract infections (UTIs) in 13 institutions in Japan were supplied between August 2002 and July 2003. The susceptibilities of these bacteria to various antimicrobial agents were examined. The bacteria were divided into 2 groups consisting of uncomplicated UTIs and complicated UTIs (with and without indwelling catheter) based on their isolation origins. The results were compared with those obtained between 1993 and 2001. The drug sensitivity of S. aureus in this year was similar to those in up to the previous year and S. aureus showed the best susceptibility to vancomycin. The drug sensitivity of E. faecalis in this year also was similar to those in up to the previous year. The drug sensitivity of E. coli in this year was generally good except penicillins and was similar to those in up to the previous year. Among cephems, cefozopran (CZOP) and cefpirome (CPR) showed the highest potency (MIC90: < or = 0.125 microg/mL). An antibacterial activity of cefotiam (CTM) was similar to it in 10 years ago and was fine (MIC90: < or = 1 microg/mL). The sensitivity of E. coli to carbapenems and carumonam (CRMN) also was good like to CZOP. However, the sensitivity of the complicated UTIs group to quinolones decreased after 2000 and was suggested to develop the resistance to the drug. The drug sensitivity of Klebsiella spp. in this year also was similar to those in up to the previous year. The bacteria showed good susceptibility (MIC: < or = 0.125 microg/mL) to cefmenoxime (CMX), CPR, cefixime (CFIX), flomoxef (FMOX), and CZOP among cephems. The drug sensitivity of P. aeruginosa was generally low. Most of the bacteria were little sensitive to cephems except CZOP and ceftazidime (CAZ). The sensitive bacteria to CZOP and ceftazidime (CAZ) were observed to be 26.8% (15/56 strains) and 39.3% (22/56 strains) in complicated UTIs group, respectively. The sensitivity profile of P. aeruginosa to the other tested drugs was not much different from that in up to the previous year. However, the sensitivity of the bacteria to carbapenems tended to decrease after 2000, and the low sensitive strains (MIC: > or = 256 microg/mL) were detected at 22.2% (2/9 strains) in the uncomplicated UTIs group and 3.6% (2/56 strains) in the complicated UTIs group.
Kumamoto
Yoshiaki
Y
Department of Urology, Sapporo Medical University School of Medicine.
Tsukamoto
Taiji
T
Matsukawa
Masanori
M
Kunishima
Yasuharu
Y
Hirose
Takaoki
T
Yamaguti
Osamu
O
Ishibashi
Kei
K
Shigeta
Shiro
S
Suzutani
Tatsuo
T
Yoshida
Hiroshi
H
Imafuku
Yuuji
Y
Murai
Masaru
M
Watanabe
Kiyoaki
K
Kobayashi
Yoshio
Y
Uchida
Hiroshi
H
Matsuda
Seiji
S
Sato
Shinichi
S
Fujime
Makoto
M
Fujita
Kazuhiko
K
Igari
Jun
J
Oguri
Toyoko
T
Yamaguchi
Keizo
K
Furuya
Nobuhiko
N
Deguchi
Takashi
T
Ishihara
Satoshi
S
Ooe
Hiroshi
H
Nishikawa
Mineko
M
Oka
Toshitsugu
T
Kitamura
Masaya
M
Fukuhara
Yoshinori
Y
Kamidono
Sadao
S
Arakawa
Soichi
S
Kumon
Hiromi
H
Monden
Koichi
K
Matsumoto
Tetsuro
T
Takahashi
Koichi
K
Naito
Seiji
S
Egashira
Toshihisa
T
Kohno
Shigeru
S
Miyazaki
Yoshitsugu
Y
Hirakata
Yoichi
Y
Aoki
Siho
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004304:Dosage Forms; D024881:Drug Resistance, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification*; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D007709:Klebsiella / Q000187:drug effects* / Q000302:isolation & purification*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*; D013997:Time Factors; D014552:Urinary Tract Infections / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D004304:Dosage Forms