The intracellular distribution and secretion of endopeptidases 24.15 (EC 3.4.24.15) and 24.16 (EC 3.4.24.16).
Endopeptidase 24.15 (EC 3.4.24.15; EP24.15) and endopeptidase 24.16 (EC 3.4.24.16; EP24.16) are enzymes involved in general peptide metabolism in mammalian cells and tissues. This review will focus on morphological and biochemical aspects related to the subcellular distribution and secretion of these homologous enzymes in the central nervous system. These are important issues for a better understanding of the functions of EP24.15 and EP24.16 within neuroendocrine systems.
Ferro
Emer S
ES
Department of Cell Biology and Development, Av. Prof. Lineu Prestes 1524, Room 431, Sao Paulo, 05504-900, Brazil. eferro@usp.br
Carreno
Flávia R
FR
Goni
Camila
C
Garrido
Paula A G
PA
Guimaraes
Alessander O
AO
Castro
Leandro M
LM
Oliveira
Vitor
V
Araujo
Maurício C
MC
Rioli
Vanessa
V
Gomes
Marcelo D
MD
Fontenele-Neto
José Domingues
JD
Hyslop
Stephen
S
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism* / Q000648:ultrastructure; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D021381:Protein Transport
D008666:Metalloendopeptidases; C022510:thimet oligopeptidase; C062316:neurolysin