Unprecedented Barbier-type reactions catalysed by titanocene(III).
Selective Barbier-type allylations, benzylations and propargylations of aldehydes and ketones can be carried out under extremely mild conditions employing titanocene(III) complexes as catalysts. In this way, chiral titanocene catalysts provided yields ranging from 50-80% of optically active products.
Rosales
Antonio
A
Department of Organic Chemistry, Faculty of Sciences, University of Granada, Spain.
Oller-López
Juan L
JL
Justicia
José
J
Gansäuer
Andreas
A
Oltra
J Enrique
JE
Cuerva
Juan M
JM