Dangerous byproducts of alcohol breakdown--focus on adducts.
Alcohol breakdown in the liver results in the generation of the reactive molecule acetaldehyde and, as a byproduct, highly reactive oxygen-containing molecules known as oxygen radicals. Both acetaldehyde and oxygen radicals can interact with proteins and other complex molecules in the cell, forming hybrid compounds called adducts. Other adducts are formed with aldehyde molecules, which are produced through the interaction of oxygen radicals with lipids in the cells. Adduct formation impedes the function of the original proteins participating in the reaction. Moreover, the adducts may induce harmful immune responses. Both of these effects may account for some of the damage observed in alcoholic liver disease. Adduct formation has been shown to occur in the livers of humans and animals consuming alcohol and to start and predominate in those liver regions that show the first signs of liver damage.
Tuma
Dean J
DJ
Omaha VA Alcohol Research Center, Department of Veterans Affairs, USA.
Casey
Carol A
CA
D000818:Animals; D000431:Ethanol / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*
D005609:Free Radicals; D017382:Reactive Oxygen Species; D000431:Ethanol