Platelet aggregation inhibition blocks C-reactive protein and interleukin-6 (IL-6) elevation after the coronary angioplasty: effect of the -174 G/C IL-6 gene polymorphism.
C-reactive protein (CRP), interleukin-6 (IL-6), and the -174 GC IL-6 gene polymorphism were analyzed after coronary angioplasty in 50 patients, 25 of whom were treated with the glycoprotein IIb/IIIa platelet receptor inhibitor eptifibatide for 24 hours. It was found that glycoprotein IIb/IIIa inhibition significantly blocked postangioplasty CRP increases in all patients but blocked IL-6 increases only in patients carrying the -174 GG genotype.
Merino
Alvaro
A
Institut Cardiologic, Clínica Rotger, Mallorca, Spain. amerino@clinicarotger.es <amerino@clinicarotger.es>
Gayá
Antonio
A
Segura
Ignacio
I
Calvo
Javier
J
Imízcoz
Cristina
C
Berenguel
Alejandro
A
Alegría
Eduardo
E
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000032:analysis*; D003327:Coronary Disease / Q000097:blood* / Q000235:genetics / Q000628:therapy; D000077542:Eptifibatide; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology; D005838:Genotype; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007262:Infusions, Intravenous; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000008:administration & dosage / Q000494:pharmacology*; D011110:Polymorphism, Genetic; D015607:Stents
D005343:Fibrinolytic Agents; D018836:Inflammation Mediators; D015850:Interleukin-6; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D002097:C-Reactive Protein; D000077542:Eptifibatide