Facile synthesis of @-tide beta-strand peptidomimetics: improved assembly in solution and on solid phase.
The synthesis of @-tide beta-strand peptidomimetics has been improved such that oligomers now can be obtained from solution- and solid-phase synthesis protocols approaching the efficiency and flexibility of peptide chemistry. These methods enable the synthesis of @-tide oligomers with a variety of amino acids and with lengths up to 13 units. [reaction: see text]
Phillips
Scott T
ST
Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.
Piersanti
Giovanni
G
Rüth
Matthias
M
Gubernator
Niko
N
van Lengerich
Bettina
B
Bartlett
Paul A
PA
D020650:Combinatorial Chemistry Techniques; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis*
D009842:Oligopeptides