title: Use of N-N bond stereodynamics in ring-closing metathesis to form medium-sized rings and macrocycles.
abstract: A unique strategy based on double ring-closing metathesis for the formation of a 14-membered macrocyclic enamide has been developed. This strategy hinges upon the well-known stereodynamic and conformational behavior of N-substituted diacylhydrazines, which promotes an effective ring-closing metathesis of hydrazine-derived dienes and enynes to form 8- to 14-membered rings.
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
authors.forename: Yi Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Daesung
authors.initials: D
authors.lastname: Lee
mesh_terms: D003500:Cyclization; D009584:Nitrogen / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009584:Nitrogen