Fusarium solani endocarditis successfully treated with liposomal amphotericin B and voriconazole.
Fungal infections caused by Fusarium in the immunocompromised host are highly resistant to all antifungal agents. Fusarium endocarditis is a rare and usually fatal disease. We report an immunocompromised child who survived Fusarium solani endocarditis despite the in vitro resistance of the organism to all available antifungal agents.
Guzman-Cottrill
Judith A
JA
Division of Infectious Disease, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Children's Memorial Hospital, Chicago, IL, USA.
Zheng
Xiaotian
X
Chadwick
Ellen G
EG
D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004696:Endocarditis / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology; D005670:Fusarium / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008081:Liposomes; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy; D011743:Pyrimidines / Q000008:administration & dosage*; D018570:Risk Assessment; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
D000935:Antifungal Agents; D008081:Liposomes; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole