title: Prevention of recurrences in patients with lone atrial fibrillation. The dose-dependent effect of angiotensin II receptor blockers.
abstract: BACKGROUND
  Atrial fibrillation (AF) leads to the activation of the renin-angiotensin system (RAS), which seems to play an important role in atrial remodelling. It is not known yet whether RAS blockade may prevent recurrences in patients with lone AF.
  
  
  RESULTS
  Patients with an episode of persistent AF for >7 days, in the absence of cardiac or extracardiac causes and with normal blood pressure values (lone AF), were recruited. Ninety patients were randomised and scheduled for electrical cardioversion. Three groups of patients were compared: Group I was treated with amiodarone 400 mg daily (30 patients), group II was treated with amiodarone 400 mg daily plus irbesartan 150 mg daily (30 patients) and group III with amiodarone 400 mg daily plus irbesartan 300 mg daily (30 patients). The primary endpoint was the time to a first recurrence of AF. The patients were cardioverted and followed. The Kaplan-Meier analysis of time to first recurrence during the follow-up period showed that patients treated with amiodarone 400 mg plus irbesartan 300 mg had a greater probability of remaining free of AF (77% vs. 52% for amiodarone and 65% for amiodarone+irbesartan 150 mg), hazard ratio for a recurrence in group III: 0.47 (95% CI 0.27-0.82; p=0.001).
  
  
  CONCLUSIONS
  The combination of irbesartan plus amiodarone decreased the rate of AF recurrences, with a dose-dependent effect, in lone AF patients.
authors.affiliation: Arrythmia Unit, Rámon y Cajal Hospital, Department of Medicine, Madrid 28034, Spain.
authors.forename: Antonio H
authors.initials: AH
authors.lastname: Madrid
authors.forename: Irene Marín
authors.initials: IM
authors.lastname: Marín
authors.forename: Carlos Escobar
authors.initials: CE
authors.lastname: Cervantes
authors.forename: Enrique Bernal
authors.initials: EB
authors.lastname: Morell
authors.forename: Jaime Escudero
authors.initials: JE
authors.lastname: Estévez
authors.forename: Gerardo
authors.initials: G
authors.lastname: Moreno
authors.forename: Jorge Rondón
authors.initials: JR
authors.lastname: Parajón
authors.forename: Jian
authors.initials: J
authors.lastname: Peng
authors.forename: Lilianna
authors.initials: L
authors.lastname: Limón
authors.forename: Sebastian
authors.initials: S
authors.lastname: Nannini
authors.forename: Concepción
authors.initials: C
authors.lastname: Moro
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000517:prevention & control* / Q000628:therapy*; D001713:Biphenyl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004554:Electric Countershock; D005260:Female; D006801:Humans; D000077405:Irbesartan; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D055502:Secondary Prevention; D016019:Survival Analysis; D013777:Tetrazoles / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001713:Biphenyl Compounds; D013777:Tetrazoles; D000077405:Irbesartan; D000638:Amiodarone