title: [Study on treatment of iron-deficiency anemia by shengxuening].
abstract: OBJECTIVE
  To observe the therapeutic effect of shengxuening (SXN) in treating iron-deficiency anemia (IDA) and to explore its molecular mechanism on iron metabolism balance regulation.
  
  
  METHODS
  Patients with IDA were randomly divided into the treated group and the control group, 50 in each group. They were treated with SXN (0.1 g, three times per day) and ferrous gluconate (0.1 g, three times per day) respectively, for 30 days. Levels of serum iron (Fe), total iron binding capacity (TIBC), transferrin saturation (TS), serum ferritin (SF), transferrin (Tf), soluble transferrin receptor (sTfR) and blood routine test, as well as scoring of TCM qi-blood deficiency Syndrome were conducted before and after treatment.
  
  
  RESULTS
  The total effective rate in the treated group reached 92%, it was shown that SXN could improve the iron metabolism, increase levels of Fe, TS, SF and reduce levels of TIBC, Tf, sTfR, it has obvious effect in promoting erythrocyte generation and could promote formation of leucocytes and platelets. The total effective rate in the control group was 32%, which was significantly lower than that in the treated group (P < 0.01).
  
  
  CONCLUSIONS
  The effect of SXN in treating IDA and qi-blood deficiency Syndrome is evident, it could improve the iron metabolism, increase levels of Fe, TS, SF and lower levels of TIBC, Tf, sTfR.
authors.affiliation: The First Hospital Affiliated to Medical School of Zhejiang University, Hangzhou 310003. keyoufu@yahoo.com.cn
authors.forename: You-fu
authors.initials: YF
authors.lastname: Ke
authors.forename: Ke-min
authors.initials: KM
authors.lastname: Wei
authors.forename: Jun-xian
authors.initials: JX
authors.lastname: Zheng
authors.forename: Jinbao
authors.initials: J
authors.lastname: Pu
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Zhu
authors.forename: Weiqing
authors.initials: W
authors.lastname: Liang
mesh_terms: D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000188:drug therapy*; D002648:Child; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011990:Receptors, Transferrin / Q000097:blood*
chemical_list: D004365:Drugs, Chinese Herbal; D011990:Receptors, Transferrin; D005293:Ferritins; D007501:Iron