Tacrolimus ointment promotes repigmentation of vitiligo in children: a review of 57 cases.
BACKGROUND
Vitiligo is an autoimmune disorder characterized by loss of pigmentation. Phototherapy and application of topical corticosteroids are most commonly prescribed. However, these therapies are often not effective and use of corticosteroids on the face may lead to cutaneous atrophy, telangiectasia, and ocular complications.


OBJECTIVE
We sought to assess the efficacy of topical tacrolimus ointment in the treatment of pediatric vitiligo.


METHODS
A retrospective review was performed of 57 pediatric patients with vitiligo at two clinical sites. Patients were treated with tacrolimus ointment for at least 3 months. Clinical responses were documented during clinic visits, and by pretacrolimus and posttacrolimus photography.


RESULTS
At least partial response was noted to tacrolimus ointment on the head and neck in 89%, and on the trunk and extremities in 63% of patients. Facial vitiligo of the segmental type showed the best response rate. Two patients initially experienced burning on application.


CONCLUSIONS
Topical tacrolimus ointment is an effective alternative therapy for childhood vitiligo, particularly involving the head and neck.
Silverberg
Nanette B
NB
Department of Dermatology, Division of Pediatric Dermatology, St Luke's-Roosevelt Hospital Center, New York, NY, USA.
Lin
Peggy
P
Travis
Lisa
L
Farley-Li
Jeanne
J
Mancini
Anthony J
AJ
Wagner
Annette M
AM
Chamlin
Sarah L
SL
Paller
Amy S
AS
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009824:Ointments; D012008:Recurrence; D012189:Retrospective Studies; D012880:Skin Pigmentation / Q000187:drug effects*; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects; D014820:Vitiligo / Q000188:drug therapy* / Q000473:pathology
D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus