title: A modified gonadotropin-releasing hormone (GnRH) antagonist protocol failed to increase clinical pregnancy rates in comparison with the long GnRH protocol.
abstract: The purpose of this prospective randomized study was to compare stimulation characteristics and IVF outcomes of the standard long GnRH agonist protocol for ovarian stimulation with a modified GnRH antagonist protocol. Starting GnRH antagonist in a flexible protocol according to the size of the leading follicle, with simultaneous augmentation of 75 IU recombinant FSH, failed to increase clinical pregnancy rates.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Loutradis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Stefanidis
authors.forename: Peter
authors.initials: P
authors.lastname: Drakakis
authors.forename: Spyridon
authors.initials: S
authors.lastname: Milingos
authors.forename: Aris
authors.initials: A
authors.lastname: Antsaklis
authors.forename: Stylianos
authors.initials: S
authors.lastname: Michalas
mesh_terms: D000328:Adult; D002985:Clinical Protocols; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D013997:Time Factors; D017329:Triptorelin Pamoate / Q000627:therapeutic use
chemical_list: D006727:Hormone Antagonists; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix