Synthesis of copolymer brushes endowed with adhesion to stainless steel surfaces and antibacterial properties by controlled nitroxide-mediated radical polymerization.
Novel copolymer brushes have been synthesized by a two-step "grafting from" method that consists of the electrografting of poly(2-phenyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethylacrylate) onto stainless steel, followed by the nitroxide-mediated radical polymerization of 2-(dimethylamino ethyl)acrylate and styrene or n-butyl acrylate, initiated from the electrografted polyacrylate chains. The grafted copolymers were quaternized in order to endow them with antibacterial properties. Peeling tests have confirmed the strong adhesion of the grafted copolymer onto the stainless steel substrate. Quartz crystal microbalance experiments have proven that fibrinogen adhesion is lower on the hydrophilic quaternized films compared to the nonionic counterpart. Such quaternized copolymers exhibit significant antibacterial activity against the Gram-positive bacteria S. aureus and the Gram-negative bacteria E. coli.
Ignatova
Milena
M
Center for Education and Research on Macromolecules (CERM), University of Liège, Sart-Tilman, B6, B-4000 Liège, Belgium.
Voccia
Samuel
S
Gilbert
Bernard
B
Markova
Nadya
N
Mercuri
Paola Sandra
PS
Galleni
Moreno
M
Sciannamea
Valérie
V
Lenoir
Sandrine
S
Cossement
Damien
D
Gouttebaron
Rachel
R
Jérôme
Robert
R
Jérôme
Christine
C
D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000268:Adhesiveness; D000269:Adhesives; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D008744:Methylamines / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000737:chemistry*; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013193:Stainless Steel / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D020058:Styrene / Q000737:chemistry; D013499:Surface Properties
C509606:2-(dimethylamino ethyl)acrylate; D000179:Acrylates; D000269:Adhesives; D000900:Anti-Bacterial Agents; D008744:Methylamines; D009589:Nitrogen Oxides; D010880:Piperidines; C509605:poly(2-phenyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethylacrylate); D013193:Stainless Steel; D020058:Styrene; C032490:n-butyl acrylate