title: Chemotherapy for bone sarcoma does not affect fertility rates or childbirth.
abstract: There have been unprecedented improvements in the survival of patients with bone sarcomas because of advances in chemotherapy during the past two decades. However, along with improved survival, there have been concerns of gonadal toxicity and fertility. These problems with chemotherapy are well documented for conditions like lymphomas and testicular cancers. There are few reports on fertility outcomes with chemotherapy for bone sarcomas. The purpose of this study was to review the rate of successful conceptions, pregnancy outcomes, incidence of birth defects, and fertility rates in young adults who had chemotherapy for high-grade bone sarcomas. A retrospective chart review of all eligible patients was done. No laboratory assessment of fertility was done. Fifteen of the 36 patients attempted conceptions, and all were successful [corrected] One miscarriage occurred and one medical termination of pregnancy was done because of a spinal metastasis. There were 13 successful full-term pregnancies with no birth defects. The conception rate was 1.6. Despite the common misconception of probable infertility, these patients can have high expectations to conceive, with uneventful childbirth and no birth defects in the newborns. Although counseling should include the possibility of infertility, patients also should be reminded of the high rate of success of having a normal conception and childbirth.
authors.affiliation: Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Harish S
authors.initials: HS
authors.lastname: Hosalkar
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Henderson
authors.forename: Arthur
authors.initials: A
authors.lastname: Weiss
authors.forename: Rakesh
authors.initials: R
authors.lastname: Donthineni
authors.forename: Richard D
authors.initials: RD
authors.lastname: Lackman
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy*; D000013:Congenital Abnormalities / Q000453:epidemiology*; D005260:Female; D005298:Fertility; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies