title: Generation and maintenance of immunological memory.
abstract: The key feature of the adaptive immune response is its specificity and the ability to generate and maintain memory. Preexisting antibodies in the circulation and at the mucosa provide the first line of defense against re-infection by extracellular as well as intracellular pathogens. Memory T cells are an important second line of defense against intracellular pathogens, and in particular against microbes that can cause chronic or latent infection. In this article we will review our current understanding of the generation and maintenance of B cell and T cell memory.
authors.affiliation: Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, 1510 Clifton Road, Atlanta, GA 30033, USA. gourley@microbio.emory.edu
authors.forename: Tania S
authors.initials: TS
authors.lastname: Gourley
authors.forename: E John
authors.initials: EJ
authors.lastname: Wherry
authors.forename: David
authors.initials: D
authors.lastname: Masopust
authors.forename: Rafi
authors.initials: R
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D007156:Immunologic Memory; D010950:Plasma Cells / Q000166:cytology / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology
chemical_list: D000906:Antibodies