Potential anti-atherogenic cell action of the naturally occurring 4-O-methyl derivative of gallic acid on Ang II-treated macrophages.
We have recently established that the blood concentrations of gallic acid (GA), a polyphenolic component naturally found in food, and its O-methyl derivatives are very low (practically < or = 1 microM) in physiological (postprandial) condition. Using acellular oxidant systems and macrophage-differentiated promonocytes (MDPs) THP-1, we show here that the direct and indirect (through depressing effect on the superoxide cell production) antioxidant properties of these components were not effective at these concentrations. In contrast, 4-O-methyl GA was the most efficient component to depress AT1R and CD36 mRNA expression in Ang II-treated MDPs, suggesting a strong inhibition of Ang II-triggered pro-atherogenic mechanisms of foam cell formation.
Oliveira
Maria V Bizerra
MV
Laboratoire de Nutrition Humaine et Athérogénèse, EA 2993, Institut de Biologie, Université Montpellier I, Montpellier, France.
Badia
Eric
E
Carbonneau
Marie-Annette
MA
Grimaldi
Paul
P
Fouret
Gilles
G
Lauret
Celine
C
Léger
Claude L
CL
D000804:Angiotensin II / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000517:prevention & control*; D001483:Base Sequence; D018955:CD36 Antigens / Q000235:genetics; D002460:Cell Line; D017931:DNA Primers; D005707:Gallic Acid / Q000494:pharmacology*; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000235:genetics; D013481:Superoxides / Q000378:metabolism
D018955:CD36 Antigens; D017931:DNA Primers; D012333:RNA, Messenger; D011945:Receptors, Angiotensin; D013481:Superoxides; D000804:Angiotensin II; D005707:Gallic Acid