title: Prolonged evolution of a lentigo maligna.
abstract: Lentigo maligna (LM) is a melanocytic lesion which is a potential precursor to melanoma and often has a prolonged intraepidermal growth phase before evolving into lentigo maligna melanoma (LMM). LM is also noted for its tendency to locally recur after treatment. We present a patient who had a persistent LM on her left cheek which, despite multiple excisions, persisted and transformed into a partially amelanotic LMM roughly three decades later. Our patient's course was also notable for this melanoma recurring at the edge of, and subsequently migrating into, a previously placed skin graft.
authors.affiliation: Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors.forename: Caroline
authors.initials: C
authors.lastname: Bevona
authors.forename: Jessica
authors.initials: J
authors.lastname: Fewkes
authors.forename: Vincent
authors.initials: V
authors.lastname: Liu
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Sober
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic; D005148:Facial Dermatoses / Q000473:pathology* / Q000601:surgery; D005153:Facial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007911:Lentigo / Q000473:pathology* / Q000601:surgery; D008545:Melanoma / Q000473:pathology*; D015580:Mohs Surgery; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery; D055502:Secondary Prevention; D016038:Skin Transplantation; D013997:Time Factors