Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: in vivo and in vitro studies.
Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low concentrations. In vivo, hypercholesterolemia-induced erythrocyte lipid peroxidation activity was inhibited by aqueous extracts of Ocimum in a dose-dependent manner in male albino rabbits. Aqueous extract feeding also provided significant liver and aortic tissue protection from hypercholesterolemia-induced peroxidative damage.
Geetha
R Kedlaya
RK
DVS College of Arts and Science, Shimoga, Pin-577 201, Karnataka, India. geethasamak@yahoo.com
Vasudevan
D M
DM
D000704:Analysis of Variance; D000818:Animals; D001011:Aorta / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism; D000431:Ethanol; D016166:Free Radical Scavengers; D006937:Hypercholesterolemia / Q000378:metabolism; D007194:India; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D031339:Ocimum / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology; D011817:Rabbits; D017392:Thiobarbituric Acid Reactive Substances
D016166:Free Radical Scavengers; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D000431:Ethanol