title: Smoking topography predicts abstinence following treatment with nicotine replacement therapy.
abstract: OBJECTIVE
  Smoking topography refers to how a person smokes a cigarette and includes measures of the number of puffs and puff volume, duration, and velocity. This study examined the relationship between smoking topography and abstinence from cigarettes following nicotine replacement therapy. A secondary objective was to determine the relationship of smoking topography to carbon monoxide (CO) exposure.
  
  
  METHODS
  Participants (n = 113) smoked one of their preferred brands of cigarette through a smoking topography device prior to participating in an open-label trial of transdermal nicotine versus nicotine nasal spray. A subset of participants (n = 50) provided breath CO samples prior to and following smoking the cigarette.
  
  
  RESULTS
  Mean V(max) [odds ratio (OR), 1.12; 95% confidence interval (95% CI), 1.02-1.24; P = 0.02], mean puff volume (OR, 0.95; 95% CI, 0.91-0.98; P = 0.01), mean interpuff interval (OR, 1.06; 95% CI, 1.00-1.11; P = 0.03), and cigarette type (full flavor versus light/ultralight; OR, 0.35; 95% CI, 0.14-0.89; P = 0.03) were significant predictors of abstinence in a model controlling for treatment group and nicotine dependence. Controlling for time since last cigarette and initial CO level, mean puff velocity (beta = 0.171; P = 0.01) was the only significant predictor of CO boost.
  
  
  CONCLUSIONS
  These results suggest that smoking topography may be useful to predict abstinence after using nicotine replacement therapy and to assess harm from smoking.
authors.affiliation: Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104-3309, USA. strasse3@mail.med.upenn.edu
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Strasser
authors.forename: Wallace B
authors.initials: WB
authors.lastname: Pickworth
authors.forename: Freda
authors.initials: F
authors.lastname: Patterson
authors.forename: Caryn
authors.initials: C
authors.lastname: Lerman
mesh_terms: D000328:Adult; D000368:Aged; D002248:Carbon Monoxide / Q000378:metabolism; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D012907:Smoking; D016540:Smoking Cessation; D016896:Treatment Outcome
chemical_list: D009538:Nicotine; D002248:Carbon Monoxide