title: Argon plasma coagulation for the treatment of early gastric cancer.
abstract: OBJECTIVE
  Endoscopic mucosal resection (EMR) is widely used to treat early gastric cancer and is considered safe and effective. However, its indication range is limited. Other endoscopic treatment options are needed for patients with surgical risks. The aim of the study was to evaluate the safety and effectiveness of argon plasma coagulation (APC) for the treatment of early gastric cancer.
  
  
  METHODS
  APC was done in 23 patients (mean age, 77.5 years) with early gastric cancer. The depth of tumor invasion, estimated primarily by endoscopic ultrasonography, was mucosal in 19 patients and submucosal in 4. EMR was not indicated in 4 cases, and 14 cases were not successfully treated by EMR alone. All patients were followed up for more than 12 months (median, 42.0+/-20.8 months).
  
  
  RESULTS
  Fifteen patients had no recurrence and survived. Four patients had no recurrence, but died of causes other than gastric cancer. Cancer recurred in four patients. Recurrence was managed by repeated treatment with APC, with no technical problems. No serious complications occurred.
  
  
  CONCLUSIONS
  APC is useful for follow-up treatment of early gastric cancer after EMR. APC may also be effective for radical treatment of early gastric cancer, especially in elderly patients and patients in whom surgical intervention is contraindicated.
authors.affiliation: Department of Internal Medicine, Murakami Memorial Hospital, Saijo City, Ehime, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Murakami
authors.forename: Keiitirou
authors.initials: K
authors.lastname: Nishino
authors.forename: Ai
authors.initials: A
authors.lastname: Inoue
authors.forename: Youko
authors.initials: Y
authors.lastname: Takaoka
authors.forename: Kikue
authors.initials: K
authors.lastname: Iwamasa
authors.forename: Bonpei
authors.initials: B
authors.lastname: Murakami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanabe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001128:Argon / Q000627:therapeutic use; D002277:Carcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D004564:Electrocoagulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D001128:Argon