'Double asymmetric induction' as a novel tool for high stereocontrol in Baylis-Hillman reaction.
The strategy of double asymmetric induction was utilized in Baylis-Hillman reaction for the first time by the coupling of chiral aldehydes with chiral acrylate (1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose-3-acrylate) to obtain corresponding adducts with high syn diastereoselectivities (de >90%) in moderate to good yields.
Krishna
Palakodety Radha
PR
D-206/B, Discovery Laboratory, Organic Chemistry Division-III Indian Institute of Chemical Technology, Hyderabad 500 007, India. prkgenius@iict.res.in
Sachwani
Rachna
R
Kannan
V
V