Protein kinases linked to the pathogenesis of Parkinson's disease.
Two papers in this issue of Neuron identify a causative gene, LRRK2, for familial parkinsonism. Several dominantly inherited missense mutations have been identified in a number of families that exhibit a broad spectrum of neuropathological features, including deposition of alpha-synuclein and tau proteins. The LRRK2 gene is predicted to encode a large protein containing leucine-rich repeats and Ras/GTPase, tyrosine kinase-like, and WD40 domains.
Shen
Jie
J
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D006801:Humans; D020125:Mutation, Missense; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics*
D011494:Protein Kinases