[The inhibitive effects of the ethanol extract from Radix et Rhizoma Rhei on the secretion of HBsAg and HBeAg].
OBJECTIVE
To study the anti-HBV effects of the ethanol extract from Radix et Rhizoma Rhei.


METHODS
The influence of the ethanol extract from Radix et Rhizoma Rhei on the secretion of HBeAg and HBsAg was observed through the culture of the 2.2.15 cell with the ethanol extract.


RESULTS
11 days after the ethanol extract's action on the 2.2.15 cell, its 50% concentration dose (CD50) is 39.69 g/L; inhibiting dose (ID50) to HBsAg and HBeAg are 3.29 g/L and 2.34 g/L respectively, and TI 12.06 and 16.96 respectively.


CONCLUSIONS
The ethanol extract from Radix et Rhizoma Rhei can markedly inhibit the secretion of HBsAg and HBeAg in 2.2.25 cell lines.
Liu
Ni
N
Institute of Tropical Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405.
Zhu
Bianxian
B
Huang
Zhengchang
Z
Zhu
Yutong
Y
Chen
Qiaoyan
Q
Guo
Xingbo
X
Li
Guoqiao
G
D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004642:Emodin / Q000494:pharmacology; D000431:Ethanol; D006514:Hepatitis B Surface Antigens / Q000096:biosynthesis*; D006513:Hepatitis B e Antigens / Q000096:biosynthesis*; D006515:Hepatitis B virus / Q000187:drug effects / Q000276:immunology; D010946:Plants, Medicinal / Q000737:chemistry*; D012250:Rheum / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D000431:Ethanol; D004642:Emodin