[Effect of compound Salvia injection on blood coagulation in patients with traumatic cerebral infarction].
OBJECTIVE
To investigate the effect of compound Salvia injection (CSI) on blood coagulatory function in patients with traumatic cerebral infarction (TCI).


METHODS
Sixty-four patients with TCI were randomly divided into two groups, 32 in each group. The treated group were treated with CSI plus conventional treatment of western medicine, and the control group treated with conventional treatment alone. Changes of symptoms, levels of plasma P-selectin (P-S), von Willebrand's factor (vWf) and D-dimer were observed with ELISA.


RESULTS
The treated group was superior to the control group in Glasgow outcome scale (P < 0.01). Before treatment, the levels of plasma P-S, vWf and D-dimer in the TCI patients were higher than those in healthy people. After treatment, all the parameters lowered in both groups, but the effect of lowering was greater in the treated group than that in the control group.


CONCLUSIONS
Blood coagulation disorder exists in patients with TCI, CSI could improve it, and might alleviate the cerebral damage to a certain extent.
Zhang
Rong-jun
RJ
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041. zhangrj1972@sina.com.cn
You
Chao
C
Cai
Bo-wen
BW
Wan
Yuqing
Y
He
Min
M
Li
Hao
H
D001777:Blood Coagulation / Q000187:drug effects*; D001930:Brain Injuries / Q000150:complications*; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D019007:P-Selectin / Q000097:blood; D008517:Phytotherapy; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013482:Superoxide Dismutase / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D019007:P-Selectin; D014841:von Willebrand Factor; D013482:Superoxide Dismutase