title: Latency of onset of de novo myelodysplastic syndromes.
abstract: The latency of onset of de novo myelodysplastic syndromes (MDS) is unknown. We report a retrospective analysis of blood counts from patients with MDS and acute myeloid leukemia (AML), and demonstrate temporal differences in rates of change of hemoglobin concentration and mean cell volume within 2-3 years of diagnosis, indicative of the earliest evidence of disease.
authors.forename: Pei-shan
authors.initials: PS
authors.lastname: Wu
authors.forename: Annette E
authors.initials: AE
authors.lastname: Hay
authors.forename: Giles E
authors.initials: GE
authors.lastname: Thomas
authors.forename: David T
authors.initials: DT
authors.lastname: Bowen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000175:diagnosis; D012189:Retrospective Studies