title: Fetal cells in mother rats contribute to the remodeling of liver and kidney after injury.
abstract: Fetal microchimerism indicates a mixture of cells of maternal and fetal origin seen in maternal tissues during and after pregnancy. Controversy exists about whether persistent fetal microchimerism is related with some autoimmune disorders occurring during and after pregnancy. In the current experiment, an animal model in which EGFP positive cells were taken as fetal-origin cells was designed to detect the fetal microchimerism in various maternal organs. Ethanol drinking and gentamicin injection were adopted to induce liver and kidney injury simultaneously. EGFP positive cells were engrafted not only in the maternal circulation and bone marrow, but also in the liver and kidney as hepatocytes and tubular cells, respectively. These results indicate that fetal cells are engrafted to maternal hematopoietic system without apparent injury and they also contribute to the repairing process of maternal liver and kidney.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Iwatani
authors.forename: Takahito
authors.initials: T
authors.lastname: Ito
authors.forename: Naoko
authors.initials: N
authors.lastname: Horimoto
authors.forename: Masaya
authors.initials: M
authors.lastname: Yamato
authors.forename: Isao
authors.initials: I
authors.lastname: Matsui
authors.forename: Enyu
authors.initials: E
authors.lastname: Imai
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
mesh_terms: D000818:Animals; D046528:Chimerism / Q000196:embryology; D000431:Ethanol; D005260:Female; D005333:Fetus / Q000473:pathology; D005839:Gentamicins; D007668:Kidney / Q000187:drug effects / Q000196:embryology / Q000473:pathology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000196:embryology* / Q000473:pathology* / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000473:pathology / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000196:embryology* / Q000473:pathology* / Q000503:physiopathology; D008115:Liver Regeneration; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration
chemical_list: D005839:Gentamicins; D000431:Ethanol