title: Likelihood-based modelling of age-related normal ranges for ordinal measurements: changes in visual acuity through early childhood.
abstract: This paper investigates the construction of age-related standards for ordinal outcome data. Asymmetric logistic models are used to describe the age-related changes in the cumulative probabilities for each ordinal level. Maximum likelihood estimation of model parameters allows the use of likelihood ratio tests to ascertain the appropriate model complexity. In contrast to methodologies for constructing age-related standards where the outcome is continuous, we show how the methodology leads directly to centile estimation for individuals. The method is illustrated using visual acuity measurements collected from 2968 children between 2 and 9 years of age made on a 30-point ordinal scale. We show how, in this instance, smoothing of parameters across ordinal categories leads to reduced validity of the centiles, justifying the need for specialized methodology for non-continuous outcomes.
authors.affiliation: Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. awade@ich.ucl.ac.uk
authors.forename: A M
authors.initials: AM
authors.lastname: Wade
authors.forename: A T
authors.initials: AT
authors.lastname: Salt
authors.forename: R V
authors.initials: RV
authors.lastname: Proffitt
authors.forename: S J
authors.initials: SJ
authors.lastname: Heavens
authors.forename: P M
authors.initials: PM
authors.lastname: Sonksen
mesh_terms: D000367:Age Factors; D001699:Biometry; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D006801:Humans; D016013:Likelihood Functions; D015233:Models, Statistical; D011336:Probability; D012016:Reference Values; D006113:United Kingdom; D014792:Visual Acuity