Nitric oxide signaling during myocardial angiogenesis.
Ischemic heart disease develops as a consequence of coronary atherosclerotic lesion formation. Coronary collateral vessels and microvascular angiogenesis develop as an adaptive response to myocardial ischemia, which ameliorates the function of the damaged heart. Angiogenesis, the formation of new blood vessels from pre-existing vascular bed, is of paramount importance in the maintenance of vascular integrity both in the repair process of damaged tissue and in the formation of collateral vessels in response to tissue ischemia. Angiogenesis is modulated by a multitude of cytokines/chemokines and growth factors. In this regard, angiogenesis cannot be viewed as a single process. It is likely that different mediators are involved in different phases of angiogenesis. Vascular endothelial cells (ECs) produce nitric oxide (NO), an endothelium-derived labile molecule, which maintains vascular homeostasis and thereby prevents vascular atherosclerotic changes. In patients with ischemic heart disease, the release of endothelium-derived NO is decreased, which plays an important role in the atherosclerotic disease progression. In recent years, endothelium-derived NO has been shown to modulate angiogenesis in vitro and in vivo. In this review, we summarize recent progress in the field of the NO-mediated regulation of postnatal angiogenesis, particularly in response to myocardial ischemia.
Kondo
Takahisa
T
Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan. takahisa@med.nagoya-u.ac.jp
Kobayashi
Koichi
K
Murohara
Toyoaki
T
D000818:Animals; D001161:Arteriosclerosis; D049109:Cell Proliferation; D004730:Endothelium, Vascular / Q000166:cytology; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases; D006801:Humans; D008954:Models, Biological; D017202:Myocardial Ischemia; D009206:Myocardium / Q000473:pathology*; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D009569:Nitric Oxide / Q000378:metabolism*; D012307:Risk Factors; D015398:Signal Transduction
D009569:Nitric Oxide