title: [Successful treatment of liver metastasis and extrahepatic metastasis with hepatic arterial infusion of CDDP, CPT-11, and 5-FU].
abstract: A 63-year-old man, who had been operated with right hemicolectomy 1 year and 3 months ago, had giant liver metastasis, lung metastasis, and local dissemination tumor due to ascending colon cancer. He was treated by systemic chemotherapy with 5-FU and the treatment evaluation was PD on CT. After admission to our hospital, he was treated by hepatic arterial infusion chemotherapy with CDDP, CPT-11, and 5-FU. After 3 courses of the treatment, each recurrent lesion decreased on CT and the CEA level decreased. There were no side effects except mild diarrhea. We believe hepatic arterial infusion chemotherapy with CDDP, CPT-11, and 5-FU may be an effective strategy against liver metastasis and extrahepatic metastsis due to colon cancer.
authors.affiliation: Dept. of Surgery, Miyazaki Prefectural Nobeoka Hospital.
authors.forename: Koichi
authors.initials: K
authors.lastname: Doi
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Ohchi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ogata
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kikuchi
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Ishimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hashimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Ochiai
authors.forename: Takahiro
authors.initials: T
authors.lastname: Muranaka
authors.forename: Michio
authors.initials: M
authors.lastname: Ogawa
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000556:secondary
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002945:Cisplatin; D005472:Fluorouracil; D002166:Camptothecin