title: [Interaction of the immune system of the organism with saprotrophic opportunistic microflora and possible coupling of the process with the metabolic status of humans].
abstract: The article sets forth the concept of natural biospheric immunization of a macroorganism by opportunistic saprotrophic microflora. Immunization by opportunistic microflora and microbial control of the metabolic status (which is coupled to the immune status of the organism) may act in a concert to provide immune defense. Efficient immunization requires that normal microflora be certified and the patients, phenotyped by the type and rate of xenobiotic biotransformation (via oxidation and acetylation). Data from the literature, based on which the suggested measures to stimulating the immune defense of the organism should be taken, are analyzed.
authors.forename: L A
authors.initials: LA
authors.lastname: Piruzian
authors.forename: E M
authors.initials: EM
authors.lastname: Mikhaĭlovskiĭ
mesh_terms: D000107:Acetylation; D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000378:metabolism* / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D009894:Opportunistic Infections / Q000276:immunology* / Q000378:metabolism* / Q000517:prevention & control; D010084:Oxidation-Reduction; D014611:Vaccination; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D015262:Xenobiotics