title: Coincidence-detection FDG-PET versus gallium in children and young adults with newly diagnosed Hodgkin's disease.
abstract: Coincidence-detection 18F-FDG-PET (PET) and 67Ga whole-body and SPECT (Ga) were compared in children and young adults with newly diagnosed Hodgkin's disease (HD).
  
  
  METHODS
  Thirty patients with histologically confirmed HD underwent PET with attenuation correction 1 h after injection of 150-220 MBq 18F-FDG and whole-body and SPECT imaging 72 h after injection of 250-370 MBq 67Ga citrate. Two experienced readers retrospectively reviewed PET and Ga scans, grading 13 anatomic regions from one (normal) to five (abnormal). Numerical stages were assigned based on Ann Arbor classification. Comparison was made with disease sites (established by biopsy or two or more of the following: physical examination, conventional imaging studies, radionuclide studies, and follow-up studies) and clinical stages. Sensitivity, specificity, and accuracy were calculated and significance of differences determined using McNemar's test.
  
  
  RESULTS
  PET detected 120/138 (87%) disease sites and Ga 109/138 (79%). PET and Ga were concordant for 103/138 (75%) sites. Accuracies were not significantly different for supradiaphragmatic disease. PET was more accurate than Ga for detecting splenic (0.91 vs 0.61, P = 0.012), infradiaphragmatic (0.89 vs 0.75, P = 0.042), and all disease sites combined (0.95 vs 0.91, P = 0.039). PET stage agreed with clinical stage in 79% of patients and Ga in 71%.
  
  
  CONCLUSIONS
  PET was superior to Ga for evaluating children and young adults with newly diagnosed HD.
authors.affiliation: Division of Nuclear Medicine, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040, USA rini@LIJ.edu
authors.forename: Josephine N
authors.initials: JN
authors.lastname: Rini
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Núñez
authors.forename: Kenneth
authors.initials: K
authors.lastname: Nichols
authors.forename: Gene G
authors.initials: GG
authors.lastname: Tronco
authors.forename: Maria Bernadette
authors.initials: MB
authors.lastname: Tomas
authors.forename: Diane
authors.initials: D
authors.lastname: Hart
authors.forename: Gungor
authors.initials: G
authors.lastname: Karayalcin
authors.forename: John C
authors.initials: JC
authors.lastname: Leonidas
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Palestro
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D012372:ROC Curve; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18