The mitochondrial death pathway and cardiac myocyte apoptosis.
Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.
Crow
Michael T
MT
Department of Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Rm 5A.58, Baltimore, MD 21224, USA. mcrow1@jhmi.edu
Mani
Kartik
K
Nam
Young-Jae
YJ
Kitsis
Richard N
RN
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051033:Apoptosis Inducing Factor; D020169:Caspases / Q000502:physiology; D045304:Cytochromes c / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000502:physiology; D004789:Enzyme Activation; D005420:Flavoproteins / Q000494:pharmacology; D005786:Gene Expression Regulation; D006331:Heart Diseases / Q000473:pathology; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008565:Membrane Proteins / Q000494:pharmacology; D008929:Mitochondria, Heart / Q000502:physiology*; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D032383:Myocytes, Cardiac / Q000166:cytology*; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000502:physiology; D012377:Rodentia; D013312:Stress, Physiological / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
C494829:AIFM1 protein, human; D051033:Apoptosis Inducing Factor; D005420:Flavoproteins; D007473:Ion Channels; D008565:Membrane Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D045304:Cytochromes c; D020169:Caspases