Phosphatidylserine-dependent antiprothrombin antibodies are not useful markers for high-risk women with recurrent miscarriages.
To determine the possible association between antiprothrombin antibodies and conventional antiphospholipid antibody (aPL) 1 (1.0%), 2 (2.0%) and 17 (17.0%) were found to be positive for phosphatidylserine-dependent antiprothrombin antibody (aPS/PT) IgG, beta2glycoprotein I-dependent anticardiolipin antibody, and lupus anticoagulant by activated partial thromboplastin time (LA), respectively, in 100 recurrent aborters. Because patients with aPS/PT were included in the 17 with LA, we should not add aPS/PT measurement to routine testing in addition to conventional aPL for patients with recurrent miscarriage.
Sugiura-Ogasawara
Mayumi
M
Department of Obstetrics and Gynecology, Nagoya City Medical School, Nagoya, Japan. og.mym@med.nagoya-cu.ac.jp
Atsumi
Tatsuya
T
Ozaki
Yasuhiko
Y
Koike
Takao
T
Suzumori
Kaoru
K
D000026:Abortion, Habitual / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D010718:Phosphatidylserines / Q000276:immunology*; D011247:Pregnancy; D011516:Prothrombin / Q000276:immunology*; D012307:Risk Factors
D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D010718:Phosphatidylserines; D011516:Prothrombin