title: How do ABC transporters drive transport?
abstract: Members of the ATP-binding cassette (ABC) superfamily are integral membrane proteins that hydrolyze ATP to drive transport. In the last two decades these proteins have been extensively characterized on a genetic and biochemical level, and in recent years high-resolution crystal structures of several nucleotide-binding domains and full-length transporters have extended our knowledge. Here we discuss the possible mechanisms of transport that have been derived from these crystal structures and the extensive available biochemical data.
authors.affiliation: Institute of Biochemistry, Biozentrum Frankfurt, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439 Frankfurt/Main, Germany.
authors.forename: Chris
authors.initials: C
authors.lastname: van der Does
authors.forename: Robert
authors.initials: R
authors.lastname: Tampé
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D001692:Biological Transport / Q000502:physiology; D006801:Humans; D017433:Protein Structure, Secondary / Q000502:physiology
chemical_list: D018528:ATP-Binding Cassette Transporters