title: Metastatic carcinoma of the colon similar to Crohn's disease: a case report.
abstract: A 68-year-old Japanese man with a history of linitis plastica carcinoma of the stomach and subsequent gastrectomy 8 years previously presented with lower abdominal pain. Radiological and endoscopic examinations showed multiple submucosal nodular lesions similar to Crohn's disease in the ileocecal area. A firm diagnosis could not be made after initial multiple biopsies. Finally, a submucosal biopsy revealed adenocarcinoma. The ileocecal lesion was diagnosed as a recurrence because of the histological findings, which included mucosal preservation, a similarity with the histologic type of stomach carcinoma, and atypical immunoreactivity for primary colon carcinoma; the lesion was negative for both cytokeratin 7 and cytokeratin 20. In cases where metastatic carcinoma of the colon is suspected, we recommend early consideration of a submucosal biopsy.
authors.affiliation: Department of Surgery, Iwakuni National Hospital, Iwakuni 740-8510, Japan. tanakaya@iwakuni-nh.go.jp
authors.forename: Kohji
authors.initials: K
authors.lastname: Tanakaya
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Yasui
authors.forename: Akira
authors.initials: A
authors.lastname: Takeda
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Umeda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Murakami
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000368:Aged; D001706:Biopsy; D018279:Carcinoma, Signet Ring Cell / Q000556:secondary*; D003110:Colonic Neoplasms / Q000556:secondary*; D003424:Crohn Disease / Q000473:pathology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology*