title: Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas.
abstract: p15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MGMT inactivation may play a pathogenetic role in a subset of CTCL.
authors.forename: Fernando
authors.initials: F
authors.lastname: Gallardo
authors.forename: Manel
authors.initials: M
authors.lastname: Esteller
authors.forename: Ramon M
authors.initials: RM
authors.lastname: Pujol
authors.forename: Carlota
authors.initials: C
authors.lastname: Costa
authors.forename: Teresa
authors.initials: T
authors.lastname: Estrach
authors.forename: Octavio
authors.initials: O
authors.lastname: Servitje
mesh_terms: D000328:Adult; D000368:Aged; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics*; D019175:DNA Methylation; D005260:Female; D019942:Genes, p16; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics*; D011401:Promoter Regions, Genetic
chemical_list: D050762:Cyclin-Dependent Kinase Inhibitor p15; D019853:O(6)-Methylguanine-DNA Methyltransferase