Association of habitual snoring with glucose and insulin metabolism in nonobese Korean adult men.
Habitual snoring is associated with cardiovascular morbidity and mortality, and metabolic abnormalities such as impaired glucose homeostasis. Many studies were performed in obese Western populations. The purpose of this study was to examine the association of habitual snoring with glucose and insulin metabolism in nonobese Korean men who were free of diabetes and hypertension. A total of 2,719 men ages 40-69 years from the Korean Health and Genome Study participated in this study. Information of snoring frequency was obtained by a questionnaire and glucose and insulin levels during oral glucose tolerance test were measured. Repeated measures analysis of variance detected significant differences in the changing patterns of glucose and insulin levels at 1 hour and 2 hours between habitual snorers and nonhabitual snorers, whereas there were no significant differences in fasting blood glucose and insulin levels. Multivariate logistic regression analyses revealed that habitual snoring was independently associated with elevated 1-hour and 2-hour glucose levels and a 2-hour insulin level, respectively. The present data suggest that habitual snoring may affect glucose-insulin metabolism, independent of diabetes and hypertension, even in nonobese Korean middle-age men. Further prospective studies are needed to examine the causal relationship between habitual snoring and insulin resistance or glucose intolerance.
Shin
Chol
C
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Human Genomic Study, Korea University, Ansan Hospital #516, Gojan-1-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Korea.
Kim
JinYoung
J
Kim
JehYeong
J
Lee
SangYeub
S
Shim
JaeJeong
J
In
KwangHo
K
Kang
KyungHo
K
Yoo
SeHwa
S
Cho
NamHan
N
Kimm
KuChan
K
Joo
SoonJae
S
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005215:Fasting; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D007723:Korea; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012913:Snoring / Q000097:blood*; D013997:Time Factors
D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D002784:Cholesterol