Rhodium-catalyzed novel trifluoromethylation at the alpha-position of alpha,beta-unsaturated ketones.
Treatment of alpha,beta-unsaturated ketones with CF(3)I in the presence of Et(2)Zn and RhCl(PPh(3))(3) gave novel alpha-trifluoromethylation products in good yields. Hydrogen transfer from the ethyl group on the rhodium complex to the beta-position of the enone seems to play an important role in this reaction.
Sato
Kazuyuki
K
Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573-0101, Japan.
Omote
Masaaki
M
Ando
Akira
A
Kumadaki
Itsumaro
I