title: Could inguinal hernia be treated medically?
abstract: Inguinal hernia is the most common congenital anomaly requiring surgical correction. The cause of the hernia is, most commonly, persistence of the processus vaginalis. Study of testicular descent in rodents has revealed a role for the genitofemoral nerve and calcitonin gene-related peptide (CGRP). Since the testis cannot descend without the processus vaginalis, we wondered whether both descent and hernia closure might be regulated by the same mechanism. Therefore, we tested the idea that CGRP might be active in closure of the inguinal hernia. Using hernial sacs removed at herniotomy operation, fusion of the hernial surfaces was induced by CGRP, but not by CGRP 8-37, CGRP 27-37 or dihydrotestosterone. Hepatocyte growth factor also caused peritoneal obliteration in vitro. We propose that obliteration of the processus vaginalis is under the control of molecules released from the genitofemoral nerve, and that a chemical treatment of inguinal hernia is at least theoretically possible.
authors.affiliation: F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Parkville, Vic. 3052, Australia. john.hutson@rch.org.au
authors.forename: John M
authors.initials: JM
authors.lastname: Hutson
authors.forename: Catherine
authors.initials: C
authors.lastname: Temelcos
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000008:administration & dosage*; D017228:Hepatocyte Growth Factor / Q000008:administration & dosage*; D006552:Hernia, Inguinal / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D006801:Humans; D007267:Injections; D008297:Male; D051381:Rats; D006848:Testicular Hydrocele / Q000150:complications / Q000188:drug therapy*; D013737:Testis / Q000187:drug effects*
chemical_list: D017228:Hepatocyte Growth Factor; D015740:Calcitonin Gene-Related Peptide