title: Health effects of exposure to ethylene glycol monoethyl ether in female workers.
abstract: Ethylene glycol monoethyl ether (EGEE) is a solvent commonly used in industry. To find the health effect of the solvent exposure in women, we did an investigation on 32 female workers exposed to EGEE in factories manufacturing photopolymer sensitization plate, and 20 subjects working in the same companies without potential exposure to the solvent. The mean age was 35.0 and 33.9 yr in the two groups, respectively. The mean concentration of the urinary metabolite (ethoxyacetic acid) was 120.87 mg/g creatinine (geometric mean) in the exposed group, and 2.71 mg/ g creatinine in the control group. Average RBC count and hemoglobin levels were normal in both groups. However, there were 2 subjects in the exposed group with an RBC count and hemoglobin concentration slightly lower than the standard. Out of 20 controls, 5 subjects reported irregular menstruation, and in comparison, 4 out of 32 exposed females had the same complaint. The most common health complaints were dizziness and swelling of the legs, with the same frequencies seen in both groups. Overall, our study suggests that although female workers were exposed to high concentrations of EGEE, subsequent health problems possibly due to such exposure were not significant.
authors.affiliation: National Institute of Industrial Health, Nagao 6-21-1, Tama-ku, Kawasaki 214-8585, Japan.
authors.forename: Rui-Sheng
authors.initials: RS
authors.lastname: Wang
authors.forename: Megumi
authors.initials: M
authors.lastname: Suda
authors.forename: Xing
authors.initials: X
authors.lastname: Gao
authors.forename: Bingling
authors.initials: B
authors.lastname: Wang
authors.forename: Tamie
authors.initials: T
authors.lastname: Nakajima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Honma
mesh_terms: D000085:Acetates / Q000652:urine; D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D016022:Case-Control Studies; D002681:China; D003404:Creatinine / Q000652:urine; D004986:Ether / Q000633:toxicity*; D019855:Ethylene Glycol / Q000633:toxicity*; D005260:Female; D006801:Humans; D007221:Industry; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012997:Solvents / Q000633:toxicity*
chemical_list: D000085:Acetates; D000395:Air Pollutants, Occupational; D012997:Solvents; D004986:Ether; C034096:ethoxyacetic acid; D003404:Creatinine; D019855:Ethylene Glycol