title: Acupuncture: a promising treatment for depression during pregnancy.
abstract: BACKGROUND
  Few medically acceptable treatments for depression during pregnancy are available. The aim of this randomized controlled pilot study was to determine whether acupuncture holds promise as a treatment for depression during pregnancy.
  
  
  METHODS
  Sixty-one pregnant women with major depressive disorder and a 17-item Hamilton Rating Scale for Depression (HRSD17) score >or=14 were randomly assigned to one of three treatments, delivered over 8 weeks: an active acupuncture (SPEC, N=20), an active control acupuncture (NSPEC, N=21), and massage (MSSG, N=20). Acupuncture treatments were standardized, but individually tailored, and were provided in a double-blind fashion. Responders to acute phase treatment (HRSD17 score<14 and >or=50% reduction from baseline) continued the treatment they were initially randomized to until 10 weeks postpartum.
  
  
  RESULTS
  Response rates at the end of the acute phase were statistically significantly higher for SPEC (69%) than for MSSG (32%), with an intermediate NSPEC response rate (47%). The SPEC group also exhibited a significantly higher average rate of reduction in BDI scores from baseline to the end of the first month of treatment than the MSSG group. Responders to the acute phase of all treatments combined had significantly lower depression scores at 10 weeks postpartum than nonresponders.
  
  
  CONCLUSIONS
  Generalizability is limited by the small sample and its relative homogeneity.
  
  
  CONCLUSIONS
  Acupuncture holds promise for the treatment of depression during pregnancy.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University. 401, Quarry Rd., Stanford, CA 94305, USA. Rmanber@stanford.edu
authors.forename: Rachel
authors.initials: R
authors.lastname: Manber
authors.forename: Rosa N
authors.initials: RN
authors.lastname: Schnyer
authors.forename: John J B
authors.initials: JJ
authors.lastname: Allen
authors.forename: A John
authors.initials: AJ
authors.lastname: Rush
authors.forename: Christine M
authors.initials: CM
authors.lastname: Blasey
mesh_terms: D015670:Acupuncture Therapy; D000328:Adult; D003865:Major Depressive Disorder / Q000150:complications / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology* / Q000628:therapy*; D016896:Treatment Outcome