Expression of cdc25A and cdc25B phosphatase in breast carcinoma.
BACKGROUND
Previous studies have indicated that cdc25B and cdc25A phosphatase stimulate cell cycle progression and also play a role in malignant transformation of cells. In this study, we investigated the expression of these phosphatases in breast carcinoma to elucidate their significance.


METHODS
We immunohistochemically examined cdc25B and cdc25A expression in 46 cases of breast carcinoma.


RESULTS
Cdc25B and cdc25A were negative or only equivocally expressed in glandular epithelial cells. In breast carcinoma, 56.5% of cases had high levels of cdc25B expression. Interestingly, the expression of cdc25B was significantly lower in cases with biologically aggressive phenotypes. The cdc25A level was high in 69.6% of cases, but we could not find any relationship between cdc25A expression and clinicopathological parameters.


CONCLUSIONS
These results suggest that cdc25B is important especially in the early phase of breast carcinoma progression.
Ito
Yasuhiro
Y
Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011, Japan. ito01@kuma-h.or.jp.
Yoshida
Hiroshi
H
Uruno
Takashi
T
Takamura
Yuuki
Y
Miya
Akihiro
A
Kuma
Kanji
K
Miyauchi
Akira
A
D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018797:Cell Cycle Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D020687:cdc25 Phosphatases / Q000032:analysis*
D018797:Cell Cycle Proteins; C517004:CDC25A protein, human; C517008:CDC25B protein, human; D020687:cdc25 Phosphatases