Decreased levofloxacin susceptibility in Haemophilus influenzae in children, Hong Kong.
Among 563 strains of Haemophilus influenzae from young children in Hong Kong, 5 (0.9%) had decreased susceptibility to quinolones. The five strains had a Ser-84-Lys or Asp-88-Asn substitution in GyrA. Pulsed-field gel electrophoresis showed that the isolates are genetically diverse.
Ho
Pak-Leung
PL
Division of Infectious Diseases, Department of Microbiology and Centre of Infection, University of Hong Kong, Hong Kong Special Administrative Region, China. plho@hkucc.hku.hk
Chow
Kin Hung
KH
Mak
Gannon C
GC
Tsang
Kenneth W
KW
Lau
Yu Lung
YL
Ho
Alex Y
AY
Lai
Eileen L
EL
Chiu
Susan S
SS
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006193:Haemophilus influenzae / Q000187:drug effects*; D006723:Hong Kong; D006801:Humans; D007223:Infant; D064704:Levofloxacin; D009268:Nalidixic Acid / Q000494:pharmacology; D009305:Nasopharynx / Q000382:microbiology; D015242:Ofloxacin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D009268:Nalidixic Acid; D064704:Levofloxacin; D015242:Ofloxacin