title: Synthesis of copolymer brushes endowed with adhesion to stainless steel surfaces and antibacterial properties by controlled nitroxide-mediated radical polymerization.
abstract: Novel copolymer brushes have been synthesized by a two-step "grafting from" method that consists of the electrografting of poly(2-phenyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethylacrylate) onto stainless steel, followed by the nitroxide-mediated radical polymerization of 2-(dimethylamino ethyl)acrylate and styrene or n-butyl acrylate, initiated from the electrografted polyacrylate chains. The grafted copolymers were quaternized in order to endow them with antibacterial properties. Peeling tests have confirmed the strong adhesion of the grafted copolymer onto the stainless steel substrate. Quartz crystal microbalance experiments have proven that fibrinogen adhesion is lower on the hydrophilic quaternized films compared to the nonionic counterpart. Such quaternized copolymers exhibit significant antibacterial activity against the Gram-positive bacteria S. aureus and the Gram-negative bacteria E. coli.
authors.affiliation: Center for Education and Research on Macromolecules (CERM), University of Liège, Sart-Tilman, B6, B-4000 Liège, Belgium.
authors.forename: Milena
authors.initials: M
authors.lastname: Ignatova
authors.forename: Samuel
authors.initials: S
authors.lastname: Voccia
authors.forename: Bernard
authors.initials: B
authors.lastname: Gilbert
authors.forename: Nadya
authors.initials: N
authors.lastname: Markova
authors.forename: Paola Sandra
authors.initials: PS
authors.lastname: Mercuri
authors.forename: Moreno
authors.initials: M
authors.lastname: Galleni
authors.forename: Valérie
authors.initials: V
authors.lastname: Sciannamea
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lenoir
authors.forename: Damien
authors.initials: D
authors.lastname: Cossement
authors.forename: Rachel
authors.initials: R
authors.lastname: Gouttebaron
authors.forename: Robert
authors.initials: R
authors.lastname: Jérôme
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000268:Adhesiveness; D000269:Adhesives; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D008744:Methylamines / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000737:chemistry*; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013193:Stainless Steel / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D020058:Styrene / Q000737:chemistry; D013499:Surface Properties
chemical_list: C509606:2-(dimethylamino ethyl)acrylate; D000179:Acrylates; D000269:Adhesives; D000900:Anti-Bacterial Agents; D008744:Methylamines; D009589:Nitrogen Oxides; D010880:Piperidines; C509605:poly(2-phenyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethylacrylate); D013193:Stainless Steel; D020058:Styrene; C032490:n-butyl acrylate