title: Three-component, stereoselective palladium-catalyzed synthesis of functionalized bicyclopentanoids.
abstract: 1,5-Cyclooctadiene can be stereoselectively transformed into a substituted bicyclo[3.3.0]octane ring system under palladium catalysis with concomitant formation of three carbon-carbon bonds. Reaction with an aryl iodide or triflate and malonate gives an exo-endo product, while the reaction with a malonate in the presence of oxygen affords a bis-endo adduct.
authors.affiliation: Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, USA. bernard_hulin@groton.pfizer.com
authors.forename: Bernard
authors.initials: B
authors.lastname: Hulin
authors.forename: Linda S
authors.initials: LS
authors.lastname: Newton
authors.forename: Shawn
authors.initials: S
authors.lastname: Cabral
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Walker
authors.forename: Jon
authors.initials: J
authors.lastname: Bordner