title: The potential of tissue engineering in orthopedics.
abstract: This article presents models of human phalanges and small joints developed by tissue engineering. Biodegradable polymer scaffolds support growth of osteoblasts, chondrocytes, and tenocytes after implantation of the models in athymic mice. The cell-polymer constructs are vascularized by the host mice, form new bone, cartilage, and tendon with characteristic gene expression and protein synthesis and secretion, and maintain the shape of human phalanges with joints. The study demonstrates critical progress in the design and fabrication of bone, cartilage, and tendon by tissue engineering and the potential of this field for human clinical orthopedic applications.
authors.affiliation: Department of Biochemistry and Molecular Pathology, Northeastern Ohio Universities, College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA. wjl@neoucom.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Landis
authors.forename: Robin
authors.initials: R
authors.lastname: Jacquet
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hillyer
authors.forename: Jean
authors.initials: J
authors.lastname: Zhang
authors.forename: Lorraine
authors.initials: L
authors.lastname: Siperko
authors.forename: Susan
authors.initials: S
authors.lastname: Chubinskaya
authors.forename: Shinichi
authors.initials: S
authors.lastname: Asamura
authors.forename: Noritaka
authors.initials: N
authors.lastname: Isogai
mesh_terms: D000818:Animals; D001186:Artificial Limbs; D001705:Bioprosthesis; D002356:Cartilage / Q000254:growth & development; D005384:Finger Joint / Q000254:growth & development; D005385:Fingers / Q000254:growth & development; D006801:Humans; D051379:Mice; D009985:Orthopedics; D010521:Periosteum / Q000254:growth & development; D013710:Tendons / Q000254:growth & development; D023822:Tissue Engineering / Q000379:methods*