title: Oxazatricyclic noradamantanes: stereocontrolled synthesis of functionalized scopolines, related cage molecules, and drug leads.
abstract: Scopolines 4 and the noradamantane scaffold are accessible from 8-oxabicyclo[3.2.1]oct-6-en-3-ones such as 6 by a concise route involving introduction of an axial amino nitrogen at C3, epoxidation, and cyclization. The resulting cage molecules are versatile drug leads.
authors.affiliation: Department of Organic Chemistry, University of Hannover, D-30167 Hannover.
authors.forename: María Vidal
authors.initials: MV
authors.lastname: Pascual
authors.forename: Steffen
authors.initials: S
authors.lastname: Proemmel
authors.forename: Winfried
authors.initials: W
authors.lastname: Beil
authors.forename: Rudolf
authors.initials: R
authors.lastname: Wartchow
authors.forename: H M R
authors.initials: HM
authors.lastname: Hoffmann
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D000470:Alkaloids / Q000138:chemical synthesis*
chemical_list: D000470:Alkaloids; D000218:Adamantane