title: Experience with mobile inhaled nitric oxide during transport of neonates and children with respiratory insufficiency to an extracorporeal membrane oxygenation center.
abstract: OBJECTIVE
  To share our experience with the use of inhaled nitric oxide (iNO) during the transport of ventilated neonates and children to an extracorporeal membrane oxygenation (ECMO) center and to discuss the efficacy and safety of iNO use in this situation.
  
  
  METHODS
  Case note review of 55 consecutive patients transported while receiving iNO to Glenfield Hospital, Leicester, UK, for consideration of ECMO.
  
  
  METHODS
  Retrospective case note review.
  
  
  METHODS
  The clinical condition of each patient recorded at arrival of the transport team at the referring hospital, during transport, and at arrival at Glenfield Hospital. Preclinical and postclinical conditions were compared using the paired Student's t-test.
  
  
  RESULTS
  Overall data showed a significant improvement in transcutaneous oximetry measurements (Spo(2): 84.8% preclinical, 90.6% postclinical; p = .006) and Pao(2) (59 torr [7.87 kPa] preclinical, 84 torr [11.23 kPa] postclinical; p = .001) during transport in our patient group. Based on limited safety data, no untoward events or toxic metabolites were observed with iNO therapy during transport.
  
  
  CONCLUSIONS
  iNO does appear to improve oxygenation during transfer of patients for ECMO in our series. Based on limited safety data, iNO appears safe to use in transport.
authors.affiliation: Heartlink ECMO Centre, Glenfield Hospital, Leicester, UK.
authors.forename: Claire
authors.initials: C
authors.lastname: Westrope
authors.forename: Neil
authors.initials: N
authors.lastname: Roberts
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Nichani
authors.forename: Carmel
authors.initials: C
authors.lastname: Hunt
authors.forename: Giles J
authors.initials: GJ
authors.lastname: Peek
authors.forename: Richard
authors.initials: R
authors.lastname: Firmin
mesh_terms: D000280:Administration, Inhalation; D001785:Blood Gas Monitoring, Transcutaneous; D016638:Critical Illness; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000188:drug therapy*; D012189:Retrospective Studies; D014187:Transportation of Patients / Q000379:methods*
chemical_list: D009569:Nitric Oxide