title: Treatment of diabetic polyneuropathy with alpha-lipoic acid is evidence based.
abstract: Searching for more efficient treatments for diabetic neuropathy continues to be a task for researchers and for practitioners also. The reasons are: the poor quality of life and the risk for ulcerations/amputations induced by peripheral diabetic neuropathy (PDP) (the most frequent manifestation of diabetic neuropathy) and the risk for sudden death and other manifestations attributed to autonomic neuropathy. There is a paucity of evidence based interventions for PDP. In this situation, the recent evidence (randomized, placebo controlled studies) regarding the efficacy of alpha-lipoic acid, a powerful antioxidant, are bringing new hopes.
authors.affiliation: University of Medicine and Pharmacy Iuliu Hatieganu, Diabetes, Nutrition and Metabolic Diseases Department, Cluj-Napoca, Romania.
authors.forename: I A
authors.initials: IA
authors.lastname: Vereşiu
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic; D008063:Thioctic Acid / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D008063:Thioctic Acid