title: Neurovirulence of mumps virus: intraspinal inoculation test in marmosets.
abstract: An intraspinal inoculation test of mumps virus using marmosets was performed in order to develop a neurovirulence test of mumps vaccines. In the group inoculated with non-neurovirulent Jeryl Lynn vaccine strain at 10(2.0) pfu/dose, there were only minimal histopathological changes in 3 of the 5 marmosets. In contrast, all marmosets inoculated with neurovirulent Urabe and NK-M46 vaccine strains developed extensive encephalitis and meningitis. Thus, this marmoset model, which can distinguish between non-neurovirulent and neurovirulent vaccine strains, is useful for evaluating neurovirulence of vaccine strains and elucidating the molecular pathogenesis of mumps.
authors.affiliation: Chiba Prefectural Institute of Public Health, 666-2 Nitona-Cho, Chuo-Ku Chiba-City, Chiba 260-8715, Japan. s.sik@ma.pref.chiba.jp
authors.forename: Shizuko
authors.initials: S
authors.lastname: Saika
authors.forename: Minoru
authors.initials: M
authors.lastname: Kidokoro
authors.forename: Atuko
authors.initials: A
authors.lastname: Aoki
authors.forename: Tokitada
authors.initials: T
authors.lastname: Ohkawa
mesh_terms: D000818:Animals; D002144:Callithrix / Q000821:virology*; D018792:Encephalitis, Viral / Q000473:pathology / Q000821:virology*; D006801:Humans; D008587:Meningitis, Viral / Q000473:pathology / Q000821:virology*; D009107:Mumps / Q000517:prevention & control* / Q000821:virology; D009108:Mumps Vaccine / Q000008:administration & dosage*; D009109:Mumps virus / Q000472:pathogenicity*; D011237:Predictive Value of Tests; D014774:Virulence
chemical_list: D009108:Mumps Vaccine