Dissolution test for ivermectin in oral veterinary paste.
A dissolution test for oral veterinary pastes with ivermectin using the Ph. Eur. paddle apparatus was developed. Sink conditions were achieved with sodium lauryl sulphate in a concentration of 0.5% as dissolution medium. By means of HPLC fast degradation of ivermectin was observed in HCl 0.1 M solution. Rotation speed of the paddle at 75 rpm was appropriate as demonstrated in a study comparing two different products.
Sznitowska
M
M
Department of Pharmaceutical Technology, Medical University of Gdansk, Poland. msznito@amg.gda.pl
Pietkiewicz
J
J
Stokrocka
M
M
Janicki
S
S
D000871:Anthelmintics / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004655:Emulsions; D006863:Hydrogen-Ion Concentration; D007559:Ivermectin / Q000008:administration & dosage* / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D013501:Surface-Active Agents
D000871:Anthelmintics; D004655:Emulsions; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D007559:Ivermectin