title: The evolution of the azoospermia factor region AZFa in higher primates.
abstract: Clones of a PAC contig encompassing the human AZFa region in Yq11.21 were comparatively FISH mapped to great ape Y chromosomes. While the orthologous AZFa locus in the chimpanzee, the bonobo and the gorilla maps to the long arm of their Y chromosomes in Yq12.1-->q12.2, Yq13.1-->q13.2 and Yq11.2, respectively, it is found on the short arm of the orang-utan subspecies of Borneo and Sumatra, in Yp12.3 and Yp13.2, respectively. Regarding the order of PAC clones and genes within the AZFa region, no differences could be detected between apes and man, indicating a strong evolutionary stability of this non-recombining region.
authors.affiliation: Institute of Human Genetics and Anthropology, University of Freiburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Wimmer
authors.forename: S
authors.initials: S
authors.lastname: Kirsch
authors.forename: G A
authors.initials: GA
authors.lastname: Rappold
authors.forename: W
authors.initials: W
authors.lastname: Schempp
mesh_terms: D000818:Animals; D002460:Cell Line; D027042:Chromosomes, Artificial, P1 Bacteriophage / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics; D033481:Chromosomes, Mammalian / Q000235:genetics; D020451:Contig Mapping / Q000379:methods; D019143:Evolution, Molecular; D056426:Genetic Loci; D006071:Gorilla gorilla / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008214:Lymphocytes / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D008254:Macaca nemestrina / Q000235:genetics; D008297:Male; D002679:Pan troglodytes / Q000235:genetics; D011148:Pongo pygmaeus / Q000235:genetics; D011323:Primates / Q000235:genetics*; D029589:Seminal Plasma Proteins / Q000235:genetics*; D014960:X Chromosome / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics
chemical_list: D029589:Seminal Plasma Proteins