Steroids from the roots of Cynanchum stauntonii.
A chemical investigation of the roots of Cynanchum stauntonii has resulted in the characterization of a new hydroperoxide with a 13,14 : 14,15-disecopregnane-type skeleton, named stauntonine (1), together with three related compounds, anhydrohirundigenin (2), anhydrohirundigenin monothevetoside (3), and glaucogenin-C mono- D-thevetoside (4). Their structures were established by spectroscopic methods, including X-ray crystallographic diffraction analysis of stauntonine that confirmed its relative stereochemistry. The compound 1 showed dose-dependent relaxation on aortic rings with endothelium contracted by phenylepherine or KCl.
Wang
Peng
P
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing , P.R. China.
Qin
Hai-Lin
HL
Zhang
Ling
L
Li
Zhi-Hong
ZH
Wang
Ying-Hong
YH
Zhu
Hai-Bo
HB
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D018360:Crystallography, X-Ray; D031105:Cynanchum; D004730:Endothelium, Vascular / Q000187:drug effects*; D010656:Phenylephrine; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D011189:Potassium Chloride; D051381:Rats; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D010936:Plant Extracts; D014665:Vasodilator Agents; D010656:Phenylephrine; D011189:Potassium Chloride