title: An early peak of relapse after surgery for breast cancer.
abstract: There is great interest among oncologists concerning what we might learn by examining the pattern of relapse after breast cancer surgery. What you see depends upon how hard you look. Up to now, investigators have examined the hazard ratio for relapse every 6-12 months. In a research paper, published in this issue of Breast Cancer Research, the Milan group have looked at the hazard ratio every three months and have found, for the first time, a distinct, very early peak of relapse in a group of premenopausal, node-positive patients not given chemotherapy or hormone therapy. What is now needed is for other groups to repeat this observation and, if found, to examine the characteristics of the tumours producing this phenomenon in order to develop hypotheses about its cause and possible treatments.
authors.affiliation: CRUK Department of Medical Oncology, Christie Hospital, University of Manchester, Manchester, UK. Anthony.Howell@christie-tr.nwest.nhs.uk
authors.forename: Anthony
authors.initials: A
authors.lastname: Howell
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology*; D016016:Proportional Hazards Models; D013997:Time Factors