title: Temporal repolarization lability differences among genotyped patients with the long QT syndrome.
abstract: The investigators sought to test whether certain long QT syndrome (LQTS) mutations are associated with increased repolarization lability and whether repolarization lability (quantified by the QT variability index [QTVI]) is increased in patients with LQTS compared with controls. In 32 genotyped patients with LQTS type 1 (LQT1), 32 genotyped patients with LQTS type 2 (LQT2), and 32 controls, the QTVI was increased in patients with LQT2 (-0.973 +/- 0.394, p = 0.01 vs controls) and in patients with LQT1 with mutations other than KCNQ1-FIN (-0.942 +/- 0.264, p = 0.04 vs controls) but was similar between the KCNQ1-FIN group and controls.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Bilchick
authors.forename: Matti
authors.initials: M
authors.lastname: Viitasalo
authors.forename: Lasse
authors.initials: L
authors.lastname: Oikarinen
authors.forename: Barry
authors.initials: B
authors.lastname: Fetics
authors.forename: Gordon
authors.initials: G
authors.lastname: Tomaselli
authors.forename: Heikki
authors.initials: H
authors.lastname: Swan
authors.forename: Päivi J
authors.initials: PJ
authors.lastname: Laitinen
authors.forename: Heikki
authors.initials: H
authors.lastname: Väänänen
authors.forename: Kimmo
authors.initials: K
authors.lastname: Kontula
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Berger
mesh_terms: D000328:Adult; D015716:Electrocardiography, Ambulatory; D005260:Female; D005838:Genotype; D006339:Heart Rate; D006801:Humans; D051656:KCNQ Potassium Channels; D051657:KCNQ1 Potassium Channel; D008133:Long QT Syndrome / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D009154:Mutation; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics
chemical_list: D051656:KCNQ Potassium Channels; D051657:KCNQ1 Potassium Channel; C496909:KCNQ1 protein, human; D024642:Potassium Channels, Voltage-Gated