The genomes of recombinant inbred lines.
Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We extend the work of Haldane and Waddington on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiple-strain RILs as a function of the level of crossover interference in meiosis.
Broman
Karl W
KW
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205-2179, USA. kbroman@jhsph.edu
D000483:Alleles; D000818:Animals; D019457:Chromosome Breakage; D002874:Chromosome Mapping; D002875:Chromosomes; D003434:Crossing Over, Genetic; D005260:Female; D008040:Genetic Linkage; D016678:Genome; D007178:Inbreeding; D008297:Male; D008540:Meiosis; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic; D014960:X Chromosome