title: Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia.
abstract: Hypomorphic mutations of the nuclear factor kappaB essential modulator gene cause ectodermal dysplasia and immunodeficiency. Affected patients have increased susceptibility to mycobacterial disease including cutaneous manifestations. We describe clinical and histopathologic characteristics of 5 patients with nuclear factor kappaB essential modulator gene mutations and mycobacterial infections, two of whom had mycobacterial cutaneous infections.
authors.affiliation: Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Yang-Shia
authors.initials: YS
authors.lastname: Dai
authors.forename: Marilyn G
authors.initials: MG
authors.lastname: Liang
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Gellis
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Bonilla
authors.forename: Lynda C
authors.initials: LC
authors.lastname: Schneider
authors.forename: Raif S
authors.initials: RS
authors.lastname: Geha
authors.forename: Jordan S
authors.initials: JS
authors.lastname: Orange
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004476:Ectodermal Dysplasia / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male; D009154:Mutation; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications / Q000235:genetics* / Q000276:immunology*; D016328:NF-kappa B / Q000235:genetics*
chemical_list: D016328:NF-kappa B