Development of CD1d-restricted NKT cells in the mouse thymus.
Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4(+)CD8(+) stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.
Dao
Tao
T
The Laboratory of T cell Immunobiology, Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, USA.
Guo
Donglin
D
Ploss
Alexander
A
Stolzer
Amy
A
Saylor
Carolyn
C
Boursalian
Tamar E
TE
Im
Jin Seon
JS
Sant'Angelo
Derek B
DB
D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D055610:Antigens, CD1d; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051076:Proto-Oncogene Proteins c-fyn; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D019061:src-Family Kinases / Q000378:metabolism
D018949:Antigens, CD1; D055610:Antigens, CD1d; D011518:Proto-Oncogene Proteins; D011948:Receptors, Antigen, T-Cell; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn; D019061:src-Family Kinases