mRNA assessment for procollagen production in women with genuine stress urinary incontinence.
The aim of the study was to examine changes in the levels of mRNA for procollagen type I and III in women with or without genuine stress incontinence (GSI). The study was performed in the 2nd Department of Obstetrics and Gynecology of University of Athens. Sixty-eight women participated in the study and they were divided in two groups. We did not find statistically significant difference between the two groups of patients in relation to the amount of mRNA of procollagen type I and III (p>0.05), but the quantity of collagen type I and III was significantly reduced in patients with stress incontinence (p<0.05). The possible cause for the reduction in the amount of collagen in women with GSI could be attributed to either a disturbance in the translation of mRNA to protein (collagen) or increased catabolism of collagen by its collagenase.
Bakas
Panagiotis G
PG
2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Athens, Greece. eurotas@panafonet.gr
Liapis
Angelos E
AE
Zervolea
Irene
I
Voutsinas
Georgios
G
Kletsas
Demetrios
D
Creatsas
Georgios
G
D000328:Adult; D024042:Collagen Type I / Q000235:genetics*; D024061:Collagen Type III / Q000235:genetics*; D003720:Densitometry; D005260:Female; D006801:Humans; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014550:Urinary Incontinence, Stress / Q000235:genetics* / Q000378:metabolism
D024042:Collagen Type I; D024061:Collagen Type III; D012333:RNA, Messenger