Unusual cytogenetic findings in a synovial sarcoma arising in the paranasal sinuses.
A fresh specimen from an intracranial tumor, which was histopatologically classified as a synovial sarcoma, was investigated cytogenetically. The direct method failed to give any information due to a lack of mitotic cells after treatment with 70% acetic acid, whereas 6-day cultures showed a 45,XY,del(6q),-10 karyotype. The histologic evaluation was consistent with a synovial sarcoma, which is well characterized from a cytogenetic perspective and involves a t(X;18)(p11;q11) in more than 95% of cases. Reverse-transcription polymerase chain reaction analysis did not show the presence of the SYT-SSX chimeric gene.
Bettio
Daniela
D
Laboratorio di Citogenetica e Genetica Medica, Istituto Clinico Humanitas, Milan, Italy. daniela.bettio@humanitas.it
Rizzi
Nicoletta
N
Colombo
Piergiuseppe
P
Bianchi
Paolo
P
Gaetani
Paolo
P
D000328:Adult; D000911:Antibodies, Monoclonal / Q000737:chemistry; D002869:Chromosome Aberrations; D003582:Cytogenetics; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008297:Male; D008938:Mitosis; D010255:Paranasal Sinus Neoplasms / Q000235:genetics* / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics* / Q000473:pathology; D013997:Time Factors; D014178:Translocation, Genetic
D000911:Antibodies, Monoclonal; D012333:RNA, Messenger