title: Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo.
abstract: It has recently been reported that the major green tea polyphenolic constituent, epigallocatechin 3-gallate (EGCG), mimics the cellular effects of insulin including the reductive effect on the gene expression of rate-limiting gluconeogenic enzymes in a cell culture system. We show that administration of green tea that contains EGCG caused a reduction in the level of mRNAs for gluconeogenic enzymes, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in the mouse liver. EGCG alone was also found to down-regulate the gene expression of these enzymes but not so curcumin or quercetin. The results of this study support the idea that green tea intake may be beneficial in the prevention of diabetes mellitus.
authors.affiliation: Laboratory of Cellular Biochemistry, COE Program in the 21st Century, Graduate School of Nutritional and Environmental Sciences, The University of Shizuoka, Shizuoka, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Koyama
authors.forename: Kouichi
authors.initials: K
authors.lastname: Abe
authors.forename: Yukimi
authors.initials: Y
authors.lastname: Sano
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ishizaki
authors.forename: Marina
authors.initials: M
authors.lastname: Njelekela
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shoji
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Mamoru
authors.initials: M
authors.lastname: Isemura
mesh_terms: D000818:Animals; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017931:DNA Primers; D003920:Diabetes Mellitus / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects; D005943:Gluconeogenesis / Q000187:drug effects*; D005952:Glucose-6-Phosphatase / Q000187:drug effects / Q000235:genetics; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017346:Protein Serine-Threonine Kinases / Q000187:drug effects / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000187:drug effects*; D011897:Random Allocation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013662:Tea
chemical_list: D017931:DNA Primers; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012333:RNA, Messenger; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; C069767:phosphoenolpyruvate carboxylase kinase; D017346:Protein Serine-Threonine Kinases; D005952:Glucose-6-Phosphatase