title: Unexpected gallbladder cancer during laparoscopic cholecystectomy.
abstract: OBJECTIVE
  In the present study, we investigated the effectiveness of surgeons in determining incidental gallbladder pathologies at laparoscopic cholecystectomy (LC).
  
  
  METHODS
  This study included 548 patients with gallstones who underwent LC between May 1, 2001 and October 15, 2003. The surgeon made an incision on the gallbladder wall for inspection, and palpated the mucosa after removing the gallbladder from the abdominal cavity to look for unsuspected pathologies. If an abnormal mucosa was observed or palpated, it was marked with a silk suture and then histopathologic examination was performed.
  
  
  RESULTS
  Fifty of 548 LC specimens were found to be suspi-cious by the surgeon. Histopathological examination of frozen sections revealed incidental pathologies in 15 of these specimens. Strikingly, 5 of these specimens were considered to have gallbladder cancer (GBC). The other incidental pathologies were consistent with adenomyomatosis, xanthogranulomatous cholecystitis, and fibroepithelial and hyperplastic polyps. Four of the other 498 specimens revealed incidental pathologies at definitive histopathological examination, and all of them were consistent with gastric metaplasia. The sensitivity and specificity of the procedure was 78.9% and 93%, respectively.
  
  
  CONCLUSIONS
  A simple prosedure; that is, incision and inspection, and palpation of the gallbladder, seems to be useful for the diagnosis of incidental gallbladder pathologies.
authors.affiliation: Department of General Surgery, Hepato Pancreato Biliary Surgery Unit, Gazi University Medical School, Ankara, Turkey.
authors.forename: Nusret
authors.initials: N
authors.lastname: Akyürek
authors.forename: Oktay
authors.initials: O
authors.lastname: Irkörücü
authors.forename: Bülent
authors.initials: B
authors.lastname: Salman
authors.forename: Ozlem
authors.initials: O
authors.lastname: Erdem
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sare
authors.forename: Ertan
authors.initials: E
authors.lastname: Tatlicioğlu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis / Q000453:epidemiology* / Q000601:surgery*; D015897:Comorbidity; D005260:Female; D005629:Frozen Sections; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity