title: The acute effect of ACEI and ARB's upon endothelin in heart failure patients.
abstract: OBJECTIVE
  to compare the acute effect of ACEI and ARB's upon the plasmatic endothelin level in heart failure patients.
  
  
  METHODS
  There were studied 30 patients with congestive heart failure, III-IV functional NYHA class, that were not under ACEI or ARB's treatment. In all the patients the endothelinl-21 plasmatic level was determined. After this, 20 patients, representing group I, received a single dose of 1 mg trandolapril, and 10 patients, representing group II, received a single dose of 40 mg telmisartan. After 24 hours, the plasmatic endothelin 1-21 level was determined again.
  
  
  RESULTS
  The mean endothelial plasmatic level was similar in both groups (group I: 0.358+/-0.04 fmol/ml; group II: 0.345+/-0.038). After 24 hours, the endothelin level decreased to 0.295+/-0.03 fmol/ml for group I (p<0.05) and to 0.287+/-0.029 fmol/ml for group II (p<0.05), suggesting that both ACEI and ARB's are equally efficient in decreasing endothelin. The initial endothelinl-21 level was inversely correlated with LVEF (r = -0.989), and the degree of the decrease of endothelinl-21 after both ACEI and ARB's is directly correlated with the initial endothelinl-21 level (r =0.64).
  
  
  CONCLUSIONS
  The acute administration of ACEI and ARB's in heart failure patients decreases the endothelin level, both categories of drugs having the same effects.
authors.affiliation: Cardiology Department, Rehabilitation Clinical Hospital, Cluj-Napoca, Romania. dzdrenghea@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Zdrenghea
authors.forename: Dana
authors.initials: D
authors.lastname: Pop
authors.forename: G
authors.initials: G
authors.lastname: Bodizs
authors.forename: Mirela
authors.initials: M
authors.lastname: Cebanu
authors.forename: Ramona
authors.initials: R
authors.lastname: Rusu
authors.forename: C S
authors.initials: CS
authors.lastname: Grosz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology*; D019332:Endothelin-1 / Q000097:blood; D016232:Endothelins / Q000097:blood*; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008875:Middle Aged; D000077333:Telmisartan
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001562:Benzimidazoles; D001565:Benzoates; D019332:Endothelin-1; D016232:Endothelins; D007211:Indoles; C052035:trandolapril; D000077333:Telmisartan