Phase evolution of lamellar cationic lipid-DNA complex: steric effect of an electrolyte.
The complexation isotherms of DNA plus lipids of a symmetric lamellar cationic lipid-DNA system were determined within a mean field free energy. The free energy incorporates the ion's finite size of NaCl simple electrolyte in solution and makes use of known structure data on this complex. The results for the predicted isotherms are in qualitative agreement with the trends of the experimental data for this property.
González-Amezcua
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Departamento de Física, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, A.P. 14-740, México Distrito Federal, México.
Hernández-Contreras
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D002412:Cations; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D044367:Phase Transition; D012965:Sodium Chloride / Q000737:chemistry*; D013237:Stereoisomerism
D002412:Cations; D004573:Electrolytes; D008055:Lipids; D012965:Sodium Chloride; D004247:DNA