[Effect of hypodynamic stress on the adrenaline-induced contraction of the smooth muscles of the thoracic aorta].
Aim of the study was to investigate the influence of hypodynamic stress on the contractile responses of the smooth muscles to adrenaline.


METHODS
Hypodynamic stress was induced by fixation of Chinchilla rabbits (n=8) in the metal hutches for 48 days (B. M. Fiodorov method). Rabbits in the control group (n=8) were kept in ordinary conditions of vivarium for the same period of time. Isolated preparations of the thoracic aorta were obtained from both groups of the rabbits. The contractile responses of the thoracic aorta preparations to 10(-7)mol/l and 10(-6)mol/l of adrenaline were registered in vitro by micromechanographic device under isometric conditions.


RESULTS
The contractile responses of the thoracic aorta preparations under the influence of adrenaline at concentration 10(-7)mol/l were not significantly higher (p>0.05) and at concentration 10(-6)mol/l they were significantly higher (p=0.021) in rabbits after hypodynamic stress than in control ones.


CONCLUSIONS
Long-term hypodynamic stress in rabbits leads to the significantly increased adrenaline-induced contraction of the smooth muscles of the thoracic aorta.
Kusleikaite
Marija
M
Institute of Cardiology, Kaunas University of Medicine, Sukileliu 17, 50009 Kaunas, Lithuania. m.kusleikaite@delfi.lt
Laukeviciene
Ale
A
Korotkich
Igor
I
Stonkus
Sigitas
S
Kevelaitis
Egidijus
E
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology*; D003627:Data Interpretation, Statistical; D004837:Epinephrine / Q000494:pharmacology*; D007103:Immobilization; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D013312:Stress, Physiological; D013997:Time Factors
D004837:Epinephrine