title: Two major metabolites of 8-prenylnaringenin are estrogenic in vitro.
abstract: 8-prenylnaringenin (8-PN) and preparations containing 8-prenylnaringenin have been suggested for use in medicinal and cosmetic applications like hormone replacement or bust enhancement. However, the safety of application is still under considerable debate. Recently it has been shown that human liver microsomes are converting 8-prenylnaringenin to 12 metabolites, with (E)-8-(4''-hydroxyisopentenyl)naringenin (8-PN-OH) and (E)-8-(4''-oxoisopentenyl)naringenin (8-PN=O) being among the most abundant. Applying two independent in vitro test systems we demonstrate that these two metabolites of 8-prenylnaringenin are estrogenic in vitro. These results represent an important piece of information towards the discussion of safety of use of preparations containing 8-prenylnaringenin.
authors.affiliation: Institute of Zoology, Dresden University of Technology, D-01062 Dresden, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Zierau
authors.forename: Stefanie
authors.initials: S
authors.lastname: Hauswald
authors.forename: Pia
authors.initials: P
authors.lastname: Schwab
authors.forename: Peter
authors.initials: P
authors.lastname: Metz
authors.forename: Günter
authors.initials: G
authors.lastname: Vollmer
mesh_terms: D044950:Flavanones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D027582:Humulus / Q000737:chemistry; D015394:Molecular Structure; D048789:Phytoestrogens / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism
chemical_list: C119737:8-prenylnaringenin; D044950:Flavanones; D048789:Phytoestrogens; D010936:Plant Extracts