title: [Histological examination of the effect of hepatic arterial infusion of degradable starch microspheres mixed with adriamycin and mitomycin C for liver metastases of colorectal cancer--second report].
abstract: We histologically examined the effect of hepatic arterial infusion of degradable starch microspheres mixed with adriamycin and mitomycin C (DSM therapy) for liver metastases of colorectal cancer. The subjects were 15 liver metastatic lesions from 9 patients with colorectal cancer who underwent potentially curative hepatectomy after DSM therapy. Ages were ranged from 36 to 71 years old (mean, 57). The ratio of male to female was 4 to 5. Six patients had synchronous lesion(s). A single injection dosage of the DSM therapy was comprised of 300-600 mg degradable starch microspheres, 30 mg ADM, and 10 mg MMC. Three lesions from the two patients who were given a single DSM therapy did not show any radiographical changes. In addition, histological examination of these lesions demonstrated a grade 1 effect. The radiographical effect of the 12 lesions from the 7 patients, who were given the DSM therapy at least three times, showed SD in 4 lesions, PR in 6 lesions, and PD in two lesions. Histological examination of these lesions demonstrated Grade 2 in 4 lesions and Grade 3 in 5 lesions. In conclusion, it was histologically confirmed that a repeated DSM therapy could cause satisfactory effects beyond expectations by radiographic imaging in patients with liver metastases of colorectal cancer.
authors.affiliation: Dept. of Surgery, Saitama Medical Center Saitama Medical School.
authors.forename: Ikuya
authors.initials: I
authors.lastname: Takeuchi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ohsawa
authors.forename: Masaru
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Takanobu
authors.initials: T
authors.lastname: Hoshino
authors.forename: Daijo
authors.initials: D
authors.lastname: Hashimoto
authors.forename: Hisato
authors.initials: H
authors.lastname: Osada
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Mastumoto
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miura
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001673:Biodegradation, Environmental; D015179:Colorectal Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D013213:Starch / Q000008:administration & dosage*
chemical_list: D016685:Mitomycin; D004317:Doxorubicin; D013213:Starch