Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina.
We developed a SHIV/macaque model of transmission from infected dams to their infants. Ten pregnant dams were infected intravenously with 100 MID(50) of macaque-titered SHIV-SF162P3 during the second trimester. Nine infants were born; the seven surviving beyond day of birth suckled for 6 months. Four of nine infants were infected (transmission rate = 44.4%), with one infection in utero, and three intrapartum and/or immediately post-birth via suckling. Varying levels of binding and neutralizing antibodies were transplacentally transferred to infants. Passive antibodies were detected in plasma on the day of birth and persisted for 5 weeks. Infants infected at or after birth controlled acute and post-acute viremia. Exposure to maternal SHIV-SF162P3 during birth and suckling in the presence of autologous maternal neutralizing antibodies may have affected transmission or pathogenesis in the infants. This transmission model can allow investigation of key parameters involved in perinatal transmission of HIV.
Jayaraman
Pushpa
P
Department of Pathobiology, University of Washington, Seattle, WA, USA.
Mohan
Deepika
D
Polacino
Patricia
P
Kuller
LaRene
L
Sheikh
Nadeem
N
Bielefeldt-Ohmann
Helle
H
Richardson
Barbra
B
Anderson
David
D
Hu
Shiu-Lok
SL
Haigwood
Nancy L
NL
D000818:Animals; D000833:Animals, Suckling; D000914:Antibodies, Viral / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018445:Infectious Disease Transmission, Vertical; D018655:Lymphocyte Count; D008254:Macaca nemestrina; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012367:RNA, Viral / Q000097:blood; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D019562:Viral Load
D000914:Antibodies, Viral; D012367:RNA, Viral