[The influence of HRT on exercise performance in women with coronary artery disease].
OBJECTIVE
The aim of this study was to evaluate the effect of hormone replacement therapy (HRT) on exercise tolerance and ischemia during treadmill exercise test.


METHODS
Prospective, cohort study.


METHODS
Fifty-six postmenopausal women with proven coronary artery disease (CAD) were enrolled into the study (31 were assigned to HRT and 25 were matched as a control group). Clinically both groups were comparable. All patients underwent treadmill exercise test at the beginning and after 12 months of follow up.


RESULTS
After 12-months of follow-up exercise tolerance increased significantly and similarly in both groups: duration time (sec): HRT 347 +/- 142 to 401 +/- 113; control 328 +/- 112 to 368 +/- 120; workload (MET): 6.6 +/- 2.1 to 6.8 +/- 2.0 and 6.1 +/- 1.9 to 6.8 +/- 1.7; time to onset of ischemia (sec): 256 +/- 116 to 293 +/- 120 and 238 +/- 87 to 299 +/- 133. Number of leads with ST changes and total sum (mm) of ST depression in all leads did not change significantly. All above parameters were comparable at baseline and after 12 months follow-up between both groups.


CONCLUSIONS
Short term, combined, transdermal HRT does not improve exercise tolerance nor coronary ischemia during exercise test in women with CAD.
Breborowicz
Piotr
P
I Klinika i Katedra Kardiologii AM w Poznaniu. piotr@kardioserwis.com
Maciejewska
Marzena
M
Katarzyńska
Agnieszka
A
Straburzyńska-Migaj
Ewa
E
Cugowska
Monika
M
Mularek-Kubzdela
Tatiana
T
Breborowicz
Elzbieta
E
Warenik-Szymankiewicz
Alina
A
Ciesliński
Andrzej
A
D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000517:prevention & control*; D003326:Coronary Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000627:therapeutic use; D005080:Exercise Test / Q000187:drug effects*; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D016387:Women's Health
D004967:Estrogens