title: Botulinum toxin type A gives adjunctive benefit to periorbital laser resurfacing.
abstract: OBJECTIVE
  Periorbital aging and lines are a result of intrinsic skin aging, ultraviolet damage, and repetitive action of periorbital muscles. Rejuvenation of this area should therefore be optimized by combining treatments that approach the different causative factors.
  
  
  METHODS
  This was a single-center, prospective, randomized, placebo-controlled study comparing the efficacy and safety of combining Botox injections (18 units per area) with ablative laser resurfacing versus laser resurfacing alone without Botox in the treatment of periorbital rhytids.
  
  
  RESULTS
  We have concluded a bilateral study comparing the effects of Botox versus saline placebo injections to the periorbital areas before and following erbium: YAG laser resurfacing of the areas in 33 patients. The results demonstrated that the Botox-treated side with laser resurfacing improved significantly more than the contralateral area treated with saline and laser in diminishing periorbital rhytids as well as textural, pigmentation, and other features of periorbital skin aging.
  
  
  CONCLUSIONS
  This study illustrates the benefits of a combined approach to treating periorbital skin aging.
authors.affiliation: UCLA School of Medicine, Los Angeles, CA, USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Yamauchi
authors.forename: GaryP
authors.initials: G
authors.lastname: Lask
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Lowe
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D003357:Cosmetic Techniques; D005152:Facial Muscles / Q000502:physiology; D005260:Female; D006801:Humans; D007267:Injections; D053685:Laser Therapy; D009119:Muscle Contraction; D015361:Rhytidoplasty; D015595:Skin Aging
chemical_list: D019274:Botulinum Toxins, Type A