Dysmorphic villi mimicking partial mole in a case with del(18)(q21).
In this article, we report the histopathologic findings in a placenta from an early second trimester abortion. The placental villi showed prominent scalloping with many intravillous trophoblastic pseudoinclusions and mild trophoblastic hyperplasia, mimicking the morphology of partial hydatidiform mole. The placental karyotype was 46,XY,del(18)(q21). These histopathologic changes have been previously described in numerical chromosomal aberrations like triploidy, tetraploidy, and trisomies, but not in structural chromosomal abnormalities.
Rakheja
Dinesh
D
Department of Pathology, Children's Medical Center of Dallas, 1935 Motor Street, Dallas, TX 75235, USA.
Wilson
Kathleen S
KS
Rogers
Beverly B
BB
D000028:Abortion, Induced; D000328:Adult; D002824:Chorionic Villi / Q000473:pathology*; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D005333:Fetus; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology*; D008297:Male; D010922:Placenta Diseases / Q000235:genetics* / Q000473:pathology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second