[Fluorinated analogs of nucleosides and fluorinated tracers of gene expression for positron emission tomography].
18F-FDG is currently the only fluorinated tracer used in routine clinical positron emission tomography (PET). Fluorine 18 is considered as the ideal radioisotope for PET, thanks to a low positron energy, which not only limits the dose rate to the patients but also provides high-resolution images. Furthermore, the 110 min. physical half-life allows for high-yield radiosynthesis, transport from the production site to the imaging site, and imaging protocols that could span hours, which permits dynamic studies and assessing metabolic processes that may be fairly slow. Recently, synthesis of fluorinated tracers from prosthetic group precursors, which allows easier radiolabeling of biomolecules, has given a boost to the development of numerous fluorinated tracers. Given the wide availability of fluorine 18, such tracers may well develop into important routine tracers. This article is a review of the literature concerning fluorinated analogs of nucleosides and fluorinated radiotracers of gene expression recently developed and under investigation.
Couturier
Olivier
O
Service de médecine nucléaire, Hôtel-Dieu, CHU, Place Alexis-Ricordeau, 44093 Nantes Cedex.
Chatal
Jean-François
JF
Hustinx
Roland
R
D000818:Animals; D000998:Antiviral Agents / Q000493:pharmacokinetics; D015224:Dideoxynucleosides / Q000493:pharmacokinetics; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D015774:Ganciclovir / Q000493:pharmacokinetics / Q000031:analogs & derivatives; D017930:Genes, Reporter; D015316:Genetic Therapy / Q000379:methods; D006147:Guanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D018139:Simplexvirus / Q000235:genetics
C471398:9-(3-fluoro-1-hydroxy-2-propoxy)methylguanine; D000998:Antiviral Agents; D015224:Dideoxynucleosides; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D006147:Guanine; D015774:Ganciclovir; C002854:alovudine