Intratympanic steroid treatment: a review.
OBJECTIVE
To review published literature regarding the use of intratympanic steroids in the treatment of Meniere's disease and sudden sensorineural hearing loss and to make recommendations regarding their use based on the literature review.


METHODS
Literature review from 1996 to 2003, PubMed, Medline Plus, and Web of Science.


METHODS
Retrospective case series and uncontrolled prospective cohort studies were the only types of studies available for review.


CONCLUSIONS
On the basis of the available literature, a weak recommendation is made to use intratympanic steroid treatment of sudden hearing loss if oral steroid therapy fails or is contraindicated. The available studies regarding intratympanic steroid treatment of Meniere's disease and tinnitus are inadequate to answer the question of the efficacy of this treatment for these conditions. Higher quality studies are needed.
Doyle
Karen Jo
KJ
Department of Otolaryngology--Head and Neck Surgery, University of California Davis, Sacramento, California 95817, USA. karen.doyle@ucdmc.ucdavis.edu
Bauch
Christopher
C
Battista
Robert
R
Beatty
Charles
C
Hughes
Gordon B
GB
Mason
John
J
Maw
Jennifer
J
Musiek
Frank L
FL
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D004432:Ear, Middle; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D007322:Instillation, Drug; D008575:Meniere Disease / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents