Intron-derived microRNAs--fine tuning of gene functions.
New evidence suggests that abundant small RNAs, microRNAs (miRNAs) act as regulatory vehicles to repress translation or cleave RNA transcripts, depending on their complementarity to the target gene, and result in modulation of gene expression. This review describes that the miRNAs derived from introns can suppress intracellular RNA homologues and regulate the gene function.
Ying
Shao-Yao
SY
Department of Cell and Neurobiology, Keck School of Medicine, BMT-401, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033-9112, USA. sying@usc.edu
Lin
Shi-Lung
SL
D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008957:Models, Genetic; D012313:RNA / Q000235:genetics / Q000378:metabolism
D035683:MicroRNAs; D012313:RNA