Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.
A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.
Cena
Clara
C
Dipartimento di Scienza e Tecnologia del Farmaco, Via P. Giuria 9, I-10125 Torino, Italy.
Boschi
Donatella
D
Tron
Gian Cesare
GC
Chegaev
Kostantin
K
Lazzarato
Loretta
L
Di Stilo
Antonella
A
Aragno
Manuela
M
Fruttero
Roberta
R
Gasco
Alberto
A
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001161:Arteriosclerosis / Q000517:prevention & control*; D001205:Ascorbic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005296:Ferrous Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010656:Phenylephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D000975:Antioxidants; D005296:Ferrous Compounds; D000960:Hypolipidemic Agents; D008563:Membrane Lipids; D020030:Nitric Oxide Donors; D010636:Phenols; D017392:Thiobarbituric Acid Reactive Substances; D010656:Phenylephrine; D001205:Ascorbic Acid