Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer.
BACKGROUND
Dietary factors, life-style as well as environmental conditions may contribute to the risk of prostate tumor together with genetic susceptibility, that may be an important factor in determining who is more likely to develop prostate malignancy. We have undertaken a case-control study in order to elucidate the association between polymorphisms in some metabolizing genes with the risk of prostate cancer (PCa).


METHODS
Polymorphisms of three xenobiotic genes (CYP17, GSTP1, PON1) were characterized in 384 patients with untreated PCa and 360 age-matched control patients with benign prostatic hyperplasia (BPH). All polymorphisms were investigated by PCR/RFLP methods using DNA from lymphocytes.


RESULTS
We found that men with the CYP17/A1A1-A1A2 genotypes, GSTP1/IleVal genotype, PON192/QR and PON55/LM-MM genotypes had a significantly higher risk of PCa compared with the others genotypes.


CONCLUSIONS
The three polymorphisms appear to be common genetic traits that are associated with an increased risk for PCa: the analysis of them all in each single case may be a predictable factor, particularly among groups exposed to PCa-related carcinogens.
Antognelli
Cinzia
C
Experimental Medicine Department, University of Perugia, Perugia, Italy.
Mearini
Luigi
L
Talesa
Vincenzo Nicola
VN
Giannantoni
Antonella
A
Mearini
Ettore
E
D000368:Aged; D000483:Alleles; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics*; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
D007527:Isoenzymes; D013254:Steroid 17-alpha-Hydroxylase; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D017430:Prostate-Specific Antigen