title: Which treatment for genital tract Chlamydia trachomatis infection?
abstract: A national opportunistic chlamydia screening programme, mainly targeting young sexually active women, is gradually being introduced across the UK and in future will predominantly occur in primary care sites. The relative efficacy of recommended antibiotic treatments for chlamydia has been poorly studied and especially that of single dose azithromycin. In Portsmouth, 1536 patients treated for chlamydia, with four different antibiotic regimens, during the Department of Health pilot study, were asked to return for test of cure. No difference in treatment outcome was found using doxycycline, oxytetracycline, erythromycin or azithromycin. Directly observed therapy with azithromycin may be especially helpful in treating young chlamydia-positive patients.
authors.affiliation: Department GU Medicine, St Mary's Hospital, Portsmouth PO3 6AD, UK. tobinj@porthosp.nhs.uk
authors.forename: J M
authors.initials: JM
authors.lastname: Tobin
authors.forename: V
authors.initials: V
authors.lastname: Harindra
authors.forename: R
authors.initials: R
authors.lastname: Mani
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis / Q000187:drug effects / Q000302:isolation & purification; D004318:Doxycycline / Q000627:therapeutic use; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010865:Pilot Projects; D012749:Sexually Transmitted Diseases / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D017963:Azithromycin; D004318:Doxycycline