Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation.
Nardilysin (NRDc), a metallopeptidase of the M16 family, presents, in vitro, cleavage specificity for basic residues. Depending on the cell type, it is cytoplasmic, exported or cell surface associated. As a new receptor for heparin-binding EGF-like growth factor (HB-EGF), NRDc was recently shown to be involved in cellular migration and proliferation. Since for those processes its enzymatic activity is not required, it is now evident that nardilysin fulfills at least two distinct functions, i.e. an HB-EGF modulator and a peptidase.
Hospital
Véronique
V
Unité de Chimie Organique, Institut Pasteur, Paris Cedex, France.
Prat
Annik
A
D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D013379:Substrate Specificity
D008666:Metalloendopeptidases; C087976:nardilysin