title: Beta3 integrins: major therapeutic targets of the near future.
abstract: Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvement in many physiological phenomena. Furthermore, their implication in various diseases and their accessibility to drugs make them interesting therapeutic targets.
authors.affiliation: Laboratoire Franco-Luxembourgeois de Recherche Biomédicale (CNRS/GDRE-ITI) Centre Universitaire 162A, avenue de la Faïencerie, L-1511 Luxembourg.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Schaffner-Reckinger
mesh_terms: D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000628:therapy; D006801:Humans; D039661:Integrin beta3 / Q000737:chemistry / Q000502:physiology; D010974:Platelet Aggregation; D013915:Thrombasthenia / Q000628:therapy
chemical_list: D015415:Biomarkers; D039661:Integrin beta3