[Dispersion of QT intervals--a myth or a diagnostic symptom?].
BACKGROUND
QT interval dispersion (QTd) is conventionally interpreted as a result of repolarization heterogeneity in ventricular myocardium. However, another concept of QTd origin has been discussed recently, suggesting that different projections of the repolarization vector into individual ECG leads could be responsible for the differences in QT interval duration. Moreover, the reproducibility could be influenced by factors both electrocardiographic (T wave amplitude, U wave) and extracardiac (noise, ECG measures). In the presented study we have followed the QTd in two groups of patients with proved changes of an electric heart field.


RESULTS
Studied groups: 1. Control group, 2. Healthy pregnant women, 3. Patients treated with dosulepine. QT interval was measured from 80 unipolar chest leads used for body surface potential mapping. The QTd was significantly higher in both experimental groups in comparison with the control group (p < 0.001). Significant correlation was found between the QTd and dosulepine plasma level (p < 0.001). Also amplitude of the T wave loop was in both groups decreased and its width increased (both p < 0.001).


CONCLUSIONS
If appropriate procedure of measurement is used, the QTd is significantly increased in many physiological and pathological states. Clinical relevancy of borderline increased values has to be interpreted very carefully.
Kittnar
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O
Fyziologický ustav 1. LF UK, Praha. otomar.kittnar@lf1.cuni.cz
Mlcek
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D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D018780:Body Surface Potential Mapping; D004308:Dothiepin / Q000494:pharmacology; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis
D000929:Antidepressive Agents, Tricyclic; D004308:Dothiepin