Effect of amiodarone on the plasma levels of metoprolol.
On average, metoprolol plasma concentration is doubled after an amiodarone loading dose (1.2 g/day over a period of 6 days). However, the individual amount of this drug interaction depends on the CYP2D6 genotype.
Werner
Dierk
D
Department of Cardiology, Helios Clinic, Schwerin, Germany. dwerner@schwerin.helios-kliniken.de <dwerner@schwerin.helios-kliniken.de>
Wuttke
Henrike
H
Fromm
Martin F
MF
Schaefer
Simon
S
Eschenhagen
Thomas
T
Brune
Kay
K
Daniel
Werner G
WG
Werner
Ulrike
U
D000368:Aged; D000483:Alleles; D000638:Amiodarone / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000493:pharmacokinetics*
D000889:Anti-Arrhythmia Agents; D019389:Cytochrome P-450 CYP2D6; D008790:Metoprolol; D000638:Amiodarone