[Stem cell therapy for urinary incontinence].
Experimental and clinical studies investigated whether urinary incontinence can be effectively treated with transurethral ultrasound-guided injections of autologous myoblasts and fibroblasts.This new therapy was performed in eight female pigs. It could be shown that the injected cells survived well and that new muscle tissue was formed. Next, 42 patients (29 women, 13 men) suffering from urinary stress incontinence were treated. The fibroblasts were mixed with a small amount of collagen as carrier material and injected into the urethral submucosa to treat atrophies of the mucosa. The myoblasts were directly injected into the rhabdosphincter to reconstruct the muscle and to heal morphological and functional defects. In 35 patients urinary incontinence could be completely cured. In seven patients who had undergone multiple surgical procedures and radiotherapy urinary incontinence improved. No side effects or complications were encountered postoperatively. The experimental as well as the clinical data clearly demonstrate that urinary incontinence can be treated effectively with autologous stem cells. The present data support the conclusion that this new therapeutic concept may represent a very promising treatment modality in the future.
Strasser
H
H
Klinik für Urologie, Medizinische Universität, Innsbruck. hannes.strasser@uibk.ac.at
Marksteiner
R
R
Margreiter
E
E
Pinggera
G-M
GM
Mitterberger
M
M
Fritsch
H
H
Klima
G
G
Rädler
C
C
Stadlbauer
K-H
KH
Fussenegger
M
M
Hering
S
S
Bartsch
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D005260:Female; D005347:Fibroblasts / Q000473:pathology / Q000637:transplantation*; D006084:Graft Rejection / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D032446:Myoblasts / Q000473:pathology / Q000637:transplantation*; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D023822:Tissue Engineering / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000175:diagnosis* / Q000601:surgery*