title: Complexity of Klebsiella pneumoniae isolates resistant to both cephamycins and extended-spectrum cephalosporins at a teaching hospital in Taiwan.
abstract: Among 99 clinical Klebsiella pneumoniae isolates resistant to cefoxitin and extended-spectrum cephalosporins, coexistence of AmpC (DHA-1, CMY-2, or CMY-8) and extended-spectrum beta-lactamases (CTX-M and/or SHV) was detected in a total of 35. The remainder produced AmpC (n = 42), extended-spectrum beta-lactamases (n = 9), metallo-beta-lactamases (n = 2), or none of these enzymes (n = 11). Phenotypic characteristics of these isolates were demonstrated.
authors.affiliation: Department of Pathology, College of Medicine, National Cheng Kung University, No. 1 University Rd., Tainan, Taiwan 70101.
authors.forename: Jing-Jou
authors.initials: JJ
authors.lastname: Yan
authors.forename: Wen-Chien
authors.initials: WC
authors.lastname: Ko
authors.forename: Hsiu-Mei
authors.initials: HM
authors.lastname: Wu
authors.forename: Shu-Huei
authors.initials: SH
authors.lastname: Tsai
authors.forename: Chin-Luan
authors.initials: CL
authors.lastname: Chuang
authors.forename: Jiunn-Jong
authors.initials: JJ
authors.lastname: Wu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018550:Cephalosporin Resistance / Q000235:genetics*; D002511:Cephalosporins / Q000494:pharmacology; D002513:Cephamycins / Q000494:pharmacology; D004269:DNA, Bacterial / Q000032:analysis; D016521:Electrophoresis, Gel, Pulsed-Field; D006784:Hospitals, Teaching; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D013624:Taiwan / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002513:Cephamycins; D004269:DNA, Bacterial; D001618:beta-Lactamases