title: Extrapulmonary small-cell carcinoma of the liver.
abstract: A 53-year-old man was admitted to our hospital for the evaluation of a mass (13 x 10 cm) in the left lobe of the liver seen by imaging studies. On subsequent biopsy of the mass, the lesion was histologically diagnosed as malignant small round-cell tumor, consistent with metastatic small-cell carcinoma. Segment IV segmentectomy was performed. On pathological examination, the mass showed a yellowish-gray granular appearance with multifocal hemorrhage and necrosis. The phenotypes shown by immunohistochemistry revealed characteristic patterns of small-cell carcinoma (neuron-specific enolase [NSE]+, synaptophysin+, c-Kit+, cluster designation [CD]56+, epithelial membrane antigen [EMA]+, cytokeratin [CK]7-). High resolution-computed tomography (HRCT) revealed inactive pulmonary tuberculosis with small calcified tuberculoma in the right upper lobe. Sputum cytology was negative for malignancy. The postoperative course was uneventful, and platinum-based chemotherapy (cisplatin, etoposide) was initiated.
authors.affiliation: Department of Surgery, Dong-A University Hospital, 3-1 Dongdaesin Dong, Seo-Gu, 602-715, Busan, Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Ryuk
authors.initials: R
authors.lastname: Kwon
authors.forename: Ghap Joong
authors.initials: GJ
authors.lastname: Jung
authors.forename: Myung Hwan
authors.initials: MH
authors.lastname: Roh
authors.forename: Sang Young
authors.initials: SY
authors.lastname: Han
authors.forename: Hyuk Chan
authors.initials: HC
authors.lastname: Kwon
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Jeong
authors.forename: Tae Beom
authors.initials: TB
authors.lastname: Shin
authors.forename: Jong Young
authors.initials: JY
authors.lastname: Oh
authors.forename: Ki Nam
authors.initials: KN
authors.lastname: Lee
mesh_terms: D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D015897:Comorbidity; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014375:Tuberculoma / Q000000981:diagnostic imaging / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging / Q000453:epidemiology; D014463:Ultrasonography