title: Detrusor overactivity. Does it represent a difference if patients feel the involuntary contractions?
abstract: OBJECTIVE
  We evaluated the differences between patients with overactive bladder (OAB) who felt involuntary detrusor contractions during cystometry (detrusor overactivity [DO]) and those who did not feel them.
  
  
  METHODS
  We prospectively studied 45 patients with symptoms of nonneurogenic, nonobstructed overactive bladder and with DO on cystometry. All patients underwent videourodynamics, the ice water test and electrical perception threshold determination. Continence, urodynamic parameters, data from specific sensory evaluation and outcome of drug treatment were examined.
  
  
  RESULTS
  Almost half of our patients did feel the contractions of DO and half did not. The groups differed significantly. Those without DO sensation were more frequently incontinent, had more involuntary detrusor contractions and these occurred earlier during bladder filling. They had involuntary start of voiding more frequently, more pathological sensation of bladder filling and lower electrical sensory thresholds. The results of drug treatment were better in the group who felt DO.
  
  
  CONCLUSIONS
  Contractions of DO are felt by some of the patients and they differ from those patients who do not feel such contractions. It is likely that this finding reflects the existence of different OAB conditions with a different neuropathological cause and a different treatment outcome. Therefore, we suggest that specific tests for the evaluation of sensation in the lower urinary tract should be part of the diagnosis of patients with DO and symptoms of OAB.
authors.affiliation: Department of Urology, University Antwerp, Antwerp, Belgium. Jean-Jacques.Wyndaele@uza.be
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Wyndaele
authors.forename: Tom David
authors.initials: TD
authors.lastname: Van Meel
authors.forename: Stefan
authors.initials: S
authors.lastname: De Wachter
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology*; D011446:Prospective Studies; D012677:Sensation; D001743:Urinary Bladder / Q000503:physiopathology*