title: Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.
abstract: A novel anti-hepatitis C virus (HCV) agent, N(3),5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine.
authors.affiliation: Pharmasset Inc., Tucker, Georgia 30084, Utah State University, Logan, Utah 84322, USA. pwang@pharmasset.com
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Wang
authors.forename: Laurent
authors.initials: L
authors.lastname: Hollecker
authors.forename: Krzysztof W
authors.initials: KW
authors.lastname: Pankiewicz
authors.forename: Steven E
authors.initials: SE
authors.lastname: Patterson
authors.forename: Tony
authors.initials: T
authors.lastname: Whitaker
authors.forename: Tamara R
authors.initials: TR
authors.lastname: McBrayer
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Tharnish
authors.forename: Robert W
authors.initials: RW
authors.lastname: Sidwell
authors.forename: Lieven J
authors.initials: LJ
authors.lastname: Stuyver
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Otto
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
authors.forename: Kyoichi A
authors.initials: KA
authors.lastname: Watanabe
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012367:RNA, Viral / Q000037:antagonists & inhibitors; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors
chemical_list: D000998:Antiviral Agents; C494561:N3,5'-cyclo-4-ribofuranosyl-vic-triazolo(4,5-b)pyridin-5-one; D009705:Nucleosides; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase