Prednicarbate (dermatop): a review.
Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis. In the past, topical steroids have been a popular choice for treating these diseases; however, the potential for significant local and systemic adverse events, such as skin atrophy and hypothalamic-pituitary-adrenal (HPA) axis suppression have limited their use. Prednicarbate has been found to have a favorable benefit-risk ratio, with low skin atrophy potential, and a high anti-inflammatory action. Prednicarbate may be particularly advantageous when used intermittently in pediatric and elderly patients.
Gupta
Aditya K
AK
Department of Medicine, Sunnybrook and Women's College Health Science Center (Sunnybrook Site) and The University of Toronto, Toronto, Canada. agupta@execulink.com
Chow
Melody
M
D000368:Aged; D002648:Child; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D006801:Humans; D011239:Prednisolone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D011239:Prednisolone; C035287:prednicarbate