title: [Infectious spondylodiscitis in a health area of Galicia (Spain) from 1983-2003].
abstract: OBJECTIVE
  To study the clinical-epidemiological characteristics of infectious spondylodiscitis (IS) in adults of our health area in the late 20 years.
  
  
  METHODS
  We performed a retrospective analysis of the medical records of adult patients with a diagnosis of both, tuberculous (TS) and non tuberculous spondylodiscitis (NTS), between January 1983 and December 2003. The diagnosis was made when compatible clinical-radiological picture were present in association with at least two positive blood cultures and/or micro-organism recovery from vertebral samples. Additionally, TS was diagnosed when biopsy showed typical caseating granulomas from vertebral or extra-vertebral lesions.
  
  
  RESULTS
  17 TS and 22 NTS were identified. The mean age was lower in patients with TS than in NTS (43.5 +/- 24.6 vs 52.0 +/- 15.2 years; mean +/- SD). Patients were predominantly males in both, TS (57%) and NTS (82%; p < 0001). The time between the onset of symptoms and diagnosis was longer in TS (16.4 +/- 15.2 weeks) than in NTS (3.9 +/- 3.2 weeks), p= 0.005. Seven (41%) of the 17 patients with TS had active extra-vertebral tuberculosis. A source of infection was presumed in 20 NTS (90%), mainly surgical spinal procedures (9/22.41%). In three TS and four NTS one o more predisposing factors were observed. The patients with NTS presented a higher prevalence of fever (41 vs 24%; p= 0.0003) and leucocytosis (41 vs 12%; p < 0.001), but less neurological impairment (9 vs 21% p= 0,01). None patient with NTS presented mixed infection and Staphylococcus aureus was the main pathogen (14/22.64%) follows by Streptococcus sp (6/22.27%). Klebsiella pneumoniae and Proteus mirabilis were the remain causative agents. Spinal cord decompression and surgical drainage of abscess were performed in five patients (24%) with TS and four patients with NTS (18%), p= 0.0027). Neurological sequels were more common in the patients with TS (24 vs 14%, p= 0.008). The global incidence of IS was 2.2 cases/105 inhabitants/year, which 1.73 cases are NTS.
  
  
  CONCLUSIONS
  The IS are a unusual disease what occurs predominantly in male patients. In the last 10 years, a increasing prevalence of NTS was observed, with high contribution (41%) of post-surgical cases. Diagnostic delay is greater in patients with TS and this condition was associated with more neurological sequels.
authors.affiliation: Servicio de Reumatología, Centro Médico Povisa, Vigo, Pontevedra, Spain. Colon28@povisa.es
authors.forename: N
authors.initials: N
authors.lastname: Gómez Rodríguez
authors.forename: Y
authors.initials: Y
authors.lastname: Penelas-Cortés Bellas
authors.forename: J
authors.initials: J
authors.lastname: Ibáñez Ruán
authors.forename: M
authors.initials: M
authors.lastname: González Pérez
authors.forename: M L
authors.initials: ML
authors.lastname: Sánchez Lorenzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002391:Catchment Area, Health; D015299:Discitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain; D014399:Tuberculosis, Spinal / Q000175:diagnosis / Q000628:therapy