[Analysis of long-term prognostic factors of epithelial ovarian cancer].
OBJECTIVE
Because most of patients with ovarian cancer are in advanced stage when initially noted, and are prone to relapse, ovarian cancer is a tough disease to treat. This study was to determine long-term prognostic factors correlated with prolonged survival of epithelial ovarian cancer patients, give reference for clinical practice.


METHODS
Records of 691 patients with epithelial ovarian cancer, admitted in our hospital from Jan. 1986 to Dec. 2000, were retrospectively analyzed. Survival rate was calculated by life table method, and relevant factors were evaluated by univariate analysis. The potential prognostic variables were studied by Cox regression model.


RESULTS
The 5-year, and 10-year survival rates of all patients were 56.0%, and 44.6%. Cox regression model revealed that clinical stage, size of tumor residues, pathologic type, histological grade, and number of chemotherapy cycles after surgery emerged as independent prognostic factors.


CONCLUSIONS
Accurate clinical staging and histopathologic assessment, satisfactory cytoreduction, and effective adequate chemotherapy may affect prognosis of ovarian cancer patients.
Li
Meng-Da
MD
Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510 060, P.R. China. Jihongl@hotmail.com
Li
Yu-Jie
YJ
Huang
Yong-Wen
YW
Huang
He
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology / Q000628:therapy*; D018284:Cystadenocarcinoma, Serous / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate