title: A randomized, double-blind comparison of lercanidipine 10 and 20 mg in patients with stable effort angina: clinical evaluation of cardiac function by ambulatory ventricular scintigraphic monitoring.
abstract: We evaluated the antiischemic action and the effects on left ventricular response to exercise of lercanidipine, a long-acting dihydropyridine calcium antagonist, in 23 patients with stable effort angina in a randomized, double-blind, parallel trial. Left ventricular function was assessed during upright bicycle exercise using an ambulatory radionuclide detector for continuous noninvasive monitoring of cardiac function. Exercise was performed under control conditions before (run-in placebo period) and after 2-week treatment with lercanidipine 10 or 20 mg once daily. During the placebo run-in period and at the study end, patients underwent clinical examination, ECG, exercise tests, ambulatory ventricular scintigraphic monitoring (VEST). Results showed that both drug doses increased time to onset of ST segment depression >/=1 mm and peak ST segment depression, with improvement of total exercise duration. Heart rate, blood pressure, and the rate-pressure product did not significantly change with respect to pretreatment value. The left ventricular ejection fraction, indicating contractility state of myocardium, was unchanged at rest and during exercise after both lercanidipine doses. In conclusion, lercanidipine is safe and effective in reducing ischemia in patients with stable effort angina without any deterioration of cardiac function.
authors.affiliation: Salvatore Maugeri Foundation, Institute of Care and Scientific Research, Rehabilitation Institute of Telese, Benevento, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Acanfora
authors.forename: Mihai
authors.initials: M
authors.lastname: Gheorghiade
authors.forename: Luigi
authors.initials: L
authors.lastname: Trojano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Furgi
authors.forename: Antimo
authors.initials: A
authors.lastname: Papa
authors.forename: Francesco
authors.initials: F
authors.lastname: Cacciatore
authors.forename: Luisa
authors.initials: L
authors.lastname: Viati
authors.forename: Francesca
authors.initials: F
authors.lastname: Mazzella
authors.forename: Franco
authors.initials: F
authors.lastname: Rengo
mesh_terms: D000789:Angina, Unstable / Q000188:drug therapy*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004095:Dihydropyridines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D016037:Single-Blind Method; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D004095:Dihydropyridines; C060343:lercanidipine