Effect of metoclopramide on pain on injection of propofol.
We undertook a randomized, double-blind, placebo-controlled study to examine the efficacy of metoclopramide at three different doses (2.5 mg, 5 mg, 10 mg) for reducing pain on injection of propofol in 100 patients scheduled for elective surgery. Patients received intravenously the study drug, with venous occlusion for one minute, followed by propofol 2 mg/kg into a dorsal hand vein. The incidence of pain was significantly less in patients receiving metoclopramide 5 mg (32%) or 10 mg (28%) than in patients receiving placebo (80%) (P<0.01). No difference between metoclopramide 2.5 mg and the placebo groups was found. We conclude that pretreatment of a dorsal hand vein with metoclopramide in a dose of 5 or 10 mg, with venous occlusion for one minute, effectively decreases the incidence of pain caused by propofol injection.
Fujii
Y
Y
Department of Anaesthesiology, University of Tsukuba Institue of Clinical Medicine, Tsukuba City, Ibaraki, Japan.
Uemura
A
A
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000768:Anesthesia, General; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage*; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement; D011336:Probability; D015742:Propofol / Q000009:adverse effects* / Q000627:therapeutic use; D012016:Reference Values; D016896:Treatment Outcome
D008787:Metoclopramide; D015742:Propofol