Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance.
Peroxisome proliferator activated receptors (PPARs) are a group of ligand-activated transcription factors that play critical roles in the regulation of energy metabolism. Synthetic agonists for these receptors are used in the treatment of type 2 diabetes mellitus and dyslipidemia. Current data linking PPAR and/or PPAR ligands with the treatment of insulin resistance will be critically reviewed, with the focus on important advances over the past year.
Patsouris
David
D
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands.
Müller
Michael
M
Kersten
Sander
S
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007333:Insulin Resistance; D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists*
D007004:Hypoglycemic Agents; D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors