Regulation of ion transport by the NHERF family of PDZ proteins.
NHERFs are the best-studied apical PDZ proteins that are highly expressed in epithelial cells. Molecular and cellular studies over the past decade show that NHERFs regulate the targeting or trafficking of ion transporters and other membrane proteins and transduce physiological and pathophysiological signals that regulate ion homeostasis in mammals.
Shenolikar
Shirish
S
Department Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Voltz
James W
JW
Cunningham
Rochelle
R
Weinman
Edward J
EJ
D000818:Animals; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D017136:Ion Transport / Q000502:physiology*; D010750:Phosphoproteins / Q000737:chemistry* / Q000502:physiology*; D017434:Protein Structure, Tertiary; D017923:Sodium-Hydrogen Exchangers
D010750:Phosphoproteins; D017923:Sodium-Hydrogen Exchangers; C093376:sodium-hydrogen exchanger regulatory factor