title: Diphenidol has no actual broad antiemetic activity in dogs and ferrets.
abstract: Previous studies showed that diphenidol was effective on emetogens-induced pica, eating of non-nutritive substances, in rats, a model analogous to emesis in other species. We evaluated the actual antiemetic activity of diphenidol against four emetic stimuli in the dog and ferret, animals that possess an emetic reflex. In dogs, emetic responses to apomorphine were significantly prevented by diphenidol (3.2 mg/kg, i.v.), whereas diphenidol (3.2 mg/kg, i.v. x 2) showed a weak inhibition to the vomiting evoked by cisplatin. In ferrets, diphenidol (10 mg/kg, i.p.) exhibited a weak antiemetic activity on the emesis induced by copper sulfate and had no activity on emesis by loperamide. On the other hand, CP-122,721, a NK1-receptor antagonist, significantly reduced the emetic episodes to all four stimuli. These results suggest that the prediction of antiemetic activity of compounds in animals lacking an emetic reflex does not always correspond with actual antiemetic activity.
authors.affiliation: Department of Urology, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
authors.forename: Hiroe
authors.initials: H
authors.lastname: Nakayama
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamakuni
authors.forename: Aya
authors.initials: A
authors.lastname: Nakayama
authors.forename: Yasue
authors.initials: Y
authors.lastname: Maeda
authors.forename: Katsunori
authors.initials: K
authors.lastname: Imazumi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Matsuo
authors.forename: Seitaro
authors.initials: S
authors.lastname: Mutoh
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology* / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D005289:Ferrets; D008297:Male; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use*; D013045:Species Specificity; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D010880:Piperidines; C004858:diphenidol