title: Organocatalyzed solvent-free aza-Henry reaction: a breakthrough in the one-pot synthesis of 1,2-diamines.
abstract: A nitrogen-containing superbase such as TMG was found to be an effective catalyst for the reaction between N-diphenylphosphinoyl imines and nitroalkanes. Exploiting a protocol that avoids the use of any solvent also during workup procedure, we synthesized a series of beta-nitroamines in excellent yields and high diastereomeric ratios. These results, combined with the capability of the indium in conjunction with Zn as the stoichiometric reducing agent to perform in aqueous medium reduction of the nitro group under mild reaction conditions, led us to devise a three-step, one-pot synthesis of a range of 1,2-diamines, making use of environmentally friendly procedures in the various steps.
authors.affiliation: Dipartimento di Chimica Organica "A. Mangini", Facoltà di Chimica Industriale, Università di Bologna, viale Risorgimento 4, 40136 Bologna, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Bernardi
authors.forename: Bianca F
authors.initials: BF
authors.lastname: Bonini
authors.forename: Elena
authors.initials: E
authors.lastname: Capito
authors.forename: Gabriella
authors.initials: G
authors.lastname: Dessole
authors.forename: Mauro
authors.initials: M
authors.lastname: Comes-Franchini
authors.forename: Mariafrancesca
authors.initials: M
authors.lastname: Fochi
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ricci