title: Synthesis of a new class of furan-fused tetracyclic compounds using o-quinodimethane chemistry and investigation of their antiviral Activity.
abstract: The synthesis and evaluation of antiviral activity of new furan-fused tetracyclic compounds are described. The syntheses were satisfactorily achieved on the basis of o-quinodimethane chemistry, using furan-containing benzocyclobutene derivatives as a substrate, in high generality and stereoselectivity. The various derivatives thus synthesized were examined on their inhibitory activity on virus growth using a hemagglutinin (HA) method, leading to a discovery of promising candidates for new antiviral drugs having high activity and good therapeutic index.
authors.affiliation: Faculty of Pharmaceutical Sciences, and Department of Human Sciences and Fundamental Nursing, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuya
authors.forename: Kazushige
authors.initials: K
authors.lastname: Sasaki
authors.forename: Mamiko
authors.initials: M
authors.lastname: Nagaoka
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kakuda
authors.forename: Naoki
authors.initials: N
authors.lastname: Toyooka
authors.forename: Nobuko
authors.initials: N
authors.lastname: Imanishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ochiai
authors.forename: Hideo
authors.initials: H
authors.lastname: Nemoto
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D003500:Cyclization; D005663:Furans / Q000737:chemistry*; D000882:Haplorhini; D006386:Hemagglutination Tests; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology; D007668:Kidney; D015394:Molecular Structure
chemical_list: D000998:Antiviral Agents; D005663:Furans; D006576:Heterocyclic Compounds, 4 or More Rings; C039281:furan