title: Protective effect of caffeine against neurodegeneration in a model of Parkinson's disease in rat: behavioral and histochemical evidence.
abstract: Epidemiological studies have consistently demonstrated an inverse association between coffee consumption and Parkinson's disease (PD). This study was designed to investigate the beneficial effect of caffeine at a dose comparable to that of human exposure in a model of PD. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with caffeine (20 mg/kg; i.p.) 1 h before surgery and treated twice a day (10 mg/kg) for 1 month. Apomorphine-induced rotations and number of Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. The results demonstrated that caffeine administration for 1 month could attenuate the rotational behavior in lesioned rats and protect the neurons of SNC against 6-OHDA toxicity.
authors.affiliation: Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Joghataie
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Roghani
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Negahdar
authors.forename: Leila
authors.initials: L
authors.lastname: Hashemi
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002110:Caffeine / Q000627:therapeutic use*; D002452:Cell Count; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D009410:Nerve Degeneration / Q000473:pathology / Q000517:prevention & control* / Q000523:psychology; D009474:Neurons / Q000473:pathology; D010302:Parkinson Disease, Secondary / Q000473:pathology / Q000517:prevention & control* / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D012399:Rotation; D013239:Stereotyped Behavior / Q000187:drug effects; D013378:Substantia Nigra / Q000473:pathology
chemical_list: D000978:Antiparkinson Agents; D000697:Central Nervous System Stimulants; D002110:Caffeine; D001058:Apomorphine