[Study of effectiveness of craving control with topiramate in patients with substance dependence disorders].
BACKGROUND
Effectiveness and tolerability of topiramate at 3 and 6 months was assessed in patients requesting dehabituation programs.


METHODS
Observational, prospective, national and multicenter study of 6 months, in patients on treatment with topiramate, who fulfilled criteria for dependence of opiates according to ICD-10 participating in therapeutic programs of dehabituation, without concomitant psychiatric illnesses and any responsible relative. Main measures of effectiveness were retention rates, alcohol consumption and other illicit drugs by urine tests (opiates, cannabis, cocaine) and treatment needs by EuropASI scale. Other parameters were HAM-D, DAS-SV and SF-36.


RESULTS
Patients with consumption by urine tests decreased from 94.1 % (n = 64) at baseline to 39.6 % (n = 19) after 6 months of treatment, as was seen by means of the mean score in EuropASI scale, for all substances except methadone. No consumption was accompanied by a low rate of relapse of 33.3 % at 6 months. Twenty one patients had adverse reactions (28 %). The most frequent adverse reactions were somnolence (n = 9; 12 %), paraesthesia (n = 5; 6.7 %) and depression (n = 4; 5.3 %).


CONCLUSIONS
In real clinical practice, topiramate showed a good response with a relevant decrease of percent of patients with abuse or consumption, and a satisfactory tolerability profile for the treatment of patients with dependence on heroine, cocaine, and other opiates, showing better outcomes than those obtained in previous trials.
Bobes
J
J
Departamento de Psiquiatría, Universidad de Oviedo, Oveido. bobes@correo.uniovi.es
Carreño
J E
JE
Gutiérrez
C E
CE
San Narciso
G I
GI
Antuña
M J
MJ
Díaz
T
T
Fernández
J J
JJ
Cerceda
A
A
Alvarez
C E
CE
Marina
P
P
García-García
M
M
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use* / Q000652:urine; D015331:Cohort Studies; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use* / Q000652:urine; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D011446:Prospective Studies; D019966:Substance-Related Disorders / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose