[Effect of enalapril, lisinopril, and amlodipine on the course of chronic gastrititis in patients with arterial hypertension].
A hundred and thirty-six patients with mild and moderate arterial hypertension (AH) who had received angiotensin-converting enzyme inhibitors (ACEIs) (enalapril and lisinopril) and the calcium channel blocker amlodipine were examined. The use of the above ACEIs promoted the normalization of proliferative processes in the epithelium of the gastric mucosa (GM) in patients with AH and concomitant chronic gastritis. This effect ofACEIs is not related to an antihypertensive effect since the antihypertensive agent amlodipine fails to exert such an effect on GM. The revealed fact of the positive effect ofACEIs not only on the morphological characteristics of GM, but also on the severity of the dyspeptic syndrome is important from the clinical point of view.
Alekseenko
S A
SA
Timoshin
S S
SS
Avilova
A A
AA
Fleĭshman
M Iu
MIu
Lamekhova
V G
VG
D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000008:administration & dosage / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D005756:Gastritis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D017706:Lisinopril / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D017311:Amlodipine; D004656:Enalapril; D017706:Lisinopril