title: Assembling the mitochondrial outer membrane.
abstract: The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.
authors.affiliation: Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany. Nikolaus.Pfanner@biochemie.uni-freiburg.de <Nikolaus.Pfanner@biochemie.uni-freiburg.de>
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Pfanner
authors.forename: Nils
authors.initials: N
authors.lastname: Wiedemann
authors.forename: Chris
authors.initials: C
authors.lastname: Meisinger
authors.forename: Trevor
authors.initials: T
authors.lastname: Lithgow
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D017209:Apoptosis; D003600:Cytosol / Q000378:metabolism; D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology*; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism; D021381:Protein Transport
chemical_list: D005656:Fungal Proteins; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; D010940:Plant Proteins; D000255:Adenosine Triphosphate