Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas.
p15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MGMT inactivation may play a pathogenetic role in a subset of CTCL.
Gallardo
Fernando
F
Esteller
Manel
M
Pujol
Ramon M
RM
Costa
Carlota
C
Estrach
Teresa
T
Servitje
Octavio
O
D000328:Adult; D000368:Aged; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics*; D019175:DNA Methylation; D005260:Female; D019942:Genes, p16; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics*; D011401:Promoter Regions, Genetic
D050762:Cyclin-Dependent Kinase Inhibitor p15; D019853:O(6)-Methylguanine-DNA Methyltransferase