Polo-like kinases and Chk2 at the interface of DNA damage checkpoint pathways and mitotic regulation.
The cell cycle controls processes of DNA replication and segregation of replicated DNA into two daughter cells. These processes are coordinated by multiple signaling pathways, which employ many protein kinases. The members of the family of Polo-like protein kinases are among these key cell cycle regulators. In response to DNA damage and inhibited DNA replication, DNA structure checkpoints delay cell cycle progression to provide cells with time for repair of damaged DNA and protect it from more severe damage. These effects are achieved by affecting key players of the basic cell cycle regulation of the cells with damaged DNA. This review is focused on the interplay between Chk2, a bona fide checkpoint protein kinase, and Polo-like kinases.
Tsvetkov
Lyuben
L
Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA. lyuben.tsvetkov@yale.edu
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000502:physiology*; D002455:Cell Division; D018385:Centrosome / Q000648:ultrastructure; D064447:Checkpoint Kinase 2; D004249:DNA Damage; D016195:G2 Phase; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D064447:Checkpoint Kinase 2; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1; C578634:CHEK2 protein, human