title: Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To examine serum leptin concentrations in obese and lean patients with polycystic ovary syndrome (PCOS) to assess whether the changes in leptin levels are due to obesity or hormonal alterations.
  
  
  METHODS
  Controlled clinical study.
  
  
  METHODS
  Academic research environment.
  
  
  METHODS
  Obese and lean women with PCOS.
  
  
  METHODS
  Blood samples were collected before and after food consumption.
  
  
  METHODS
  Serum leptin and insulin levels.
  
  
  RESULTS
  Serum leptin concentrations were significantly correlated with body mass index (r = 0.649) and also with HOMA (r = 0.535). However, after controlling for body mass index in a partial correlation analysis, no significant correlation was found between serum leptin levels and HOMA or hyperinsulinemia. While lean patients with PCOS had a significant correlation between leptin concentrations and obesity parameters, they did not show any significant correlation with insulin resistance parameters.
  
  
  CONCLUSIONS
  Although leptin concentrations in women with PCOS correlate with insulin resistance/hyperinsulinemia, this is related only to obesity.
authors.affiliation: Department of Endocrinology, Uludag University Hospital, Bursa, Turkey.
authors.forename: Erdinc
authors.initials: E
authors.lastname: Erturk
authors.forename: Nesrin
authors.initials: N
authors.lastname: Kuru
authors.forename: Vahide
authors.initials: V
authors.lastname: Savci
authors.forename: Ercan
authors.initials: E
authors.lastname: Tuncel
authors.forename: Canan
authors.initials: C
authors.lastname: Ersoy
authors.forename: Sazi
authors.initials: S
authors.lastname: Imamoglu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006706:Homeostasis; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications* / Q000473:pathology / Q000503:physiopathology
chemical_list: D020738:Leptin