title: [Cryopreservation of semen of adolescents and young adult men with cancer].
abstract: The importance of cryopreserving semen for young male cancer patients is illustrated in three case descriptions. A 28-year-old man with chronic myeloid leukaemia that resulted in azoospermia, later fathered a child with his semen that had been stored prior to chemotherapy. In an 18-year-old adolescent with non-Hodgkin lymphoma the possibility to store cryopreserved semen was only raised after chemotherapy had been started and had caused azoospermia. This caused the patient serious regret. A 14-year-old boy with acute lymphatic leukaemia had his semen stored despite initial hesitations due to his young age. The cancer hardly ever affects the semen quality to the extent that cryopreservation of the semen becomes impossible. The aim should be to obtain several ejaculates prior to the cancer therapy and to store multiple portions, so that later a number of fertilisation attempts are possible. The primary attending physician is initially responsible for raising the possibility of semen cryopreservation. Ideally, however, all health professionals involved should be aware of this aspect. There is a need for multidisciplinary protocols for oncology centres and sperm banks, so that the timely informing of patients is guaranteed, responsibilities are recorded--with appropriate procedures to prevent unnecessary delay--and procedures that concur with legal requirements and financial constraints are established.
authors.affiliation: Afd. Klinisch-Chemisch Laboratorium, Ziekenhuis Rijnstate, Postbus 9555, 6800 TA Arnhem. pjanssens@alysis.nl
authors.forename: P M W
authors.initials: PM
authors.lastname: Janssens
authors.forename: C C M
authors.initials: CC
authors.lastname: Beerendonk
authors.forename: E
authors.initials: E
authors.lastname: Blokzijl
authors.forename: D D M
authors.initials: DD
authors.lastname: Braat
authors.forename: J R
authors.initials: JR
authors.lastname: Westphal
authors.forename: J A M
authors.initials: JA
authors.lastname: Kremer
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015925:Cryopreservation; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D009845:Oligospermia / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D012661:Semen / Q000187:drug effects; D012662:Semen Preservation / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents