title: Modulating role of glucose on magnesium transport in rat erythrocytes.
abstract: Magnesium efflux from rat erythrocytes has been shown to be inhibited by a plasma fraction containing glucose. Therefore, we investigated the effect of D-glucose on erythrocyte magnesium transport. We show the inhibitory activity of this hexose on sodium (Na(+))-independent erythrocyte magnesium (Mg(2+)E) efflux. Inhibitory effects of D-mannose, 2-deoxy-D-glucose, and D-fructose on Mg(2+)E efflux also were demonstrated. Moreover, the suppression of the inhibitory activity of glucose on Mg(2+)E efflux was shown to be associated with the inhibition of glucose transport by cytochalasin B and phloretin. Together these data suggest a possible implication of the glucose carrier GLUT-1 in the regulation of Mg(2+) transport.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
authors.forename: G
authors.initials: G
authors.lastname: Franck
authors.forename: J
authors.initials: J
authors.lastname: Wdzieczak-Bakala
authors.forename: J G
authors.initials: JG
authors.lastname: Henrotte