title: Management of renal masses in patients medically unsuitable for nephrectomy--natural history, complications, and outcome.
abstract: OBJECTIVE
  To examine a group of elderly patients with much larger tumors who were deemed unlikely to survive surgery or who would require dialysis postoperatively to establish the natural history of larger renal tumors if left untreated. Little is known of the growth rate and natural history of renal cancer progression because the tumor is usually removed in those patients who can tolerate surgery. The only published data have been in relation to unfit patients with small, homogeneous, well-circumscribed tumors less than 4 cm.
  
  
  METHODS
  We identified 36 patients whose tumor had not been removed, without evidence of metastasis at diagnosis, from a database of 421 patients with renal cancer. The data were examined retrospectively for symptoms, survival, and size change.
  
  
  RESULTS
  The mean age of the patients treated conservatively was 76.1 years (range 56 to 91), with median tumor size of 6.0 cm (range 3.5 to 20.0) at diagnosis. The median follow-up period was 24 months (range 3 to 136). Of the 36 patients, 13 had died at follow-up, 8 of an unrelated illness and 5 of an unknown cause with no radiologic evidence of progression but severe comorbidity. The median time to death was 9 months (range 3 to 24) after diagnosis. One patient developed metastasis at 132 months and was still alive at 136 months of follow-up. Significant hematuria occurred in 11% of the patients and was successfully managed either conservatively or by embolization. The tumor size was unchanged in most patients during the follow-up period.
  
  
  CONCLUSIONS
  In elderly patients, or those with severe comorbidity, conservative management of larger renal masses is a reasonable and safe option.
authors.affiliation: Department of Urology, Gartnavel General Hospital, Glasgow, United Kingdom.
authors.forename: Gavin W A
authors.initials: GW
authors.lastname: Lamb
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Bromwich
authors.forename: Paul
authors.initials: P
authors.lastname: Vasey
authors.forename: Michael
authors.initials: M
authors.lastname: Aitchison
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D002423:Cause of Death; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009929:Organ Size; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography