The utility of superparamagnetic contrast agents in MRI: theoretical consideration and applications in the cardiovascular system.
This review will discuss the in vivo physical chemical relaxation properties of superparamagnetic iron oxide particles. Various parameters such as size, magnetization, compartmentalization and water exchange effects and how these alter the behavior of the iron oxide particles in an in vitro vs an in vivo situation with special reference to the cardiovascular system will be exemplified. Furthermore, applications using iron oxide particles for vascular, perfusion and viability imaging as well as assessment of the inflammatory status of a given tissue will be discussed.
Bjørnerud
Atle
A
Department of Radiology, Rikshospitalet University Hospital, N-0027 Oslo, Norway. atle.bjornerud@rikshospitalet.no
Johansson
Lars
L
D000818:Animals; D009202:Cardiomyopathies / Q000175:diagnosis / Q000378:metabolism; D003198:Computer Simulation; D003287:Contrast Media; D005290:Ferric Compounds / Q000493:pharmacokinetics; D006331:Heart Diseases / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008955:Models, Cardiovascular; D010316:Particle Size; D014652:Vascular Diseases / Q000175:diagnosis* / Q000378:metabolism
D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide