Impact of inflammation and oxidative stress on vascular calcifications in chronic kidney disease.
Vascular and/or valvular calcifications in patients with chronic kidney disease (CKD) appear to indicate a poor prognosis in terms of overall survival and cardiovascular morbidity and mortality. Inflammation and oxidative stress represent new features of the arterial and/or valvular calcification process. However, only limited observational and epidemiological data are available in these areas. Therefore, the link between inflammation, oxidation and vascular and/or valvular calcifications deserves careful consideration in CKD patients, since they may become targets for the development of new therapeutic strategies.
Massy
Z A
ZA
EA2087, Amiens University Hospital, UPJV, Amiens, France. massy@u-picardie.fr
Mazière
C
C
Kamel
S
S
Brazier
M
M
Choukroun
G
G
Tribouilloy
C
C
Slama
M
M
Andrejak
M
M
Mazière
J C
JC
D002114:Calcinosis / Q000209:etiology* / Q000378:metabolism; D002648:Child; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000150:complications; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism; D018384:Oxidative Stress; D014652:Vascular Diseases / Q000209:etiology* / Q000378:metabolism