Artificial oxygen carriers for trauma: myth or reality.
Two-unit blood transfusion accounts for one third of blood use in trauma patients. Artificial oxygen carriers have no need for cross-match, allow volume expansion, prolonged storage at 1-38 degrees C, and improve rheology to reverse ischaemia. Haemoglobin-based oxygen carriers can provide a vital alternative given the predicted future shortfall in blood donations.
Mackenzie
Colin F
CF
Charles McC Mathias Jr National Study Center for Trauma and Emergency Medical Systems, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Bucci
Cyndi
C
D000740:Anemia / Q000628:therapy; D001802:Blood Substitutes / Q000009:adverse effects / Q000627:therapeutic use*; D001803:Blood Transfusion / Q000379:methods; D017326:Clinical Trials, Phase III as Topic; D000075202:Contraindications; D006454:Hemoglobins / Q000627:therapeutic use*; D006801:Humans; D014947:Wounds and Injuries / Q000628:therapy*
D001802:Blood Substitutes; D006454:Hemoglobins