Detection of a new cerebral malaria susceptibility locus, using CBA mice.
Human cerebral malaria (CM) during acute Plasmodium falciparum infection is a serious neurological complication that leads to coma and death. P. berghei ANKA infection of CBA mice is a useful experimental model of CM. To identify host susceptibility loci, we performed chromosomal mapping in crossbred populations of both CM-susceptible CBA and CM-resistant DBA/2 mice. One significant region for a CM-susceptible locus in CBA mice was mapped to H2 region on Chromosome 17, tentatively designated cmsc. cmsc was mapped to a different chromosomal region from that previously reported in the C57BL/6 mouse model of CM. It is possible that different loci contribute to CM in CBA and C57BL/6 mouse strains. Comparison of the function of CM susceptibility loci between CBA and C57BL/6 mice could have important implications for the study of the complex pathogenesis of CM in humans.
Ohno
Tamio
T
Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagoya University, Showa-ku, Nagoya 466-8550, Japan. ohno@med.nagoya-u.ac.jp
Nishimura
Masahiko
M
D000818:Animals; D016009:Chi-Square Distribution; D002874:Chromosome Mapping; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D016779:Malaria, Cerebral / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D010962:Plasmodium berghei / Q000276:immunology
D005819:Genetic Markers