title: Conducting international collaborative research in developing nations.
abstract: International research partnerships bring together some of the best and the brightest in an effort to tackle global health problems. Such collaborations also pose complex challenges, such as maintaining ethical principles in the conduct of research in developing nations. In implementing a randomized clinical trial to reduce postpartum hemorrhage (PPH) during childbirth in rural India, U.S. and Indian collaborators addressed three such issues: the appropriateness of an ethical randomized controlled trial in the developing world, the inclusion of a placebo arm, and the relevance of informed consent in a semiliterate rural population.
authors.affiliation: Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, IL 60612, USA. sgeller@uic.edu
authors.forename: S E
authors.initials: SE
authors.lastname: Geller
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: V A
authors.initials: VA
authors.lastname: Niak
authors.forename: S S
authors.initials: SS
authors.lastname: Goudar
authors.forename: S A
authors.initials: SA
authors.lastname: Edlavitch
authors.forename: B S
authors.initials: BS
authors.lastname: Kodkany
authors.forename: R J
authors.initials: RJ
authors.lastname: Derman
mesh_terms: D000284:Administration, Oral; D003906:Developing Countries; D004311:Double-Blind Method; D004522:Educational Status; D032984:Ethics, Research; D005260:Female; D006381:Helsinki Declaration; D006801:Humans; D007194:India; D007258:Informed Consent; D007391:International Cooperation; D016595:Misoprostol / Q000627:therapeutic use; D015337:Multicenter Studies as Topic; D010120:Oxytocics / Q000627:therapeutic use; D006473:Postpartum Hemorrhage / Q000517:prevention & control; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D019035:Rural Health Services; D012424:Rural Population
chemical_list: D010120:Oxytocics; D016595:Misoprostol