title: Diverse mechanisms regulate stem cell self-renewal.
abstract: To what extent are the pathways that regulate self-renewal conserved between stem cells at different stages of development and in different tissues? Some pathways play a strikingly conserved role in regulating the self-renewal of diverse stem cells, whereas other pathways are specific to stem cells in certain tissues or at certain stages of development. Recent studies have highlighted differences between the self-renewal of embryonic, fetal and adult stem cells. By understanding these similarities and differences we may come to a molecular understanding of how stem cells replicate themselves and why aspects of this process differ between stem cells.
authors.affiliation: Howard Hughes Medical Institute, and Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Drive, 3215 CCGC, Ann Arbor, Michigan 48109-0934, USA.
authors.forename: Anna V
authors.initials: AV
authors.lastname: Molofsky
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pardal
authors.forename: Sean J
authors.initials: SJ
authors.lastname: Morrison
mesh_terms: D000818:Animals; D002453:Cell Cycle; D019070:Cell Lineage; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology*; D053823:Hedgehog Proteins; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D063150:Polycomb Repressive Complex 1; D051880:Receptors, Notch; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*; D013997:Time Factors; D051153:Wnt Proteins
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C066770:Pc protein, Drosophila; D051880:Receptors, Notch; D051153:Wnt Proteins; C077245:hh protein, Drosophila; D063150:Polycomb Repressive Complex 1