title: Long-term effects of tibolone on mammographic density.
abstract: OBJECTIVE
  To investigate the long-term effect of tibolone on mammographic density.
  
  
  METHODS
  Open-label, nonrandomized study.
  
  
  METHODS
  Academic research environment.
  
  
  METHODS
  Postmenopausal women.
  
  
  METHODS
  Tibolone was administered orally, mammograms were performed annually.
  
  
  METHODS
  Mammographic density according to the Wolfe classification, performed by two independent radiologists, both of whom were blinded to treatment group.
  
  
  RESULTS
  No statistically significant differences were found between the two groups in baseline demographic data. There were no statistically significant differences in mammographic density between the control and active groups at baseline or at 10 years.
  
  
  CONCLUSIONS
  This pilot study shows that tibolone does not adversely alter the mammographic density of the breasts over 10 years of treatment.
authors.affiliation: Menopause Research Unit, Guy's Hospital, London, United Kingdom. debs_bruce@hotmail.com
authors.forename: Deborah
authors.initials: D
authors.lastname: Bruce
authors.forename: Jillian
authors.initials: J
authors.lastname: Robinson
authors.forename: Sarah
authors.initials: S
authors.lastname: McWilliams
authors.forename: Mamatha
authors.initials: M
authors.lastname: Reddy
authors.forename: Ian
authors.initials: I
authors.lastname: Fentiman
authors.forename: Janice
authors.initials: J
authors.lastname: Rymer
mesh_terms: D000284:Administration, Oral; D001940:Breast / Q000187:drug effects*; D016022:Case-Control Studies; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008327:Mammography; D008875:Middle Aged; D009652:Norpregnenes / Q000008:administration & dosage / Q000627:therapeutic use*; D010024:Osteoporosis / Q000517:prevention & control; D010865:Pilot Projects; D016037:Single-Blind Method
chemical_list: D009652:Norpregnenes; C027385:tibolone