[The role of corticosteroids in the lungs' maturation in expected premature birth].
Cortikosteroids, a hormons of adrenal glands have a influence to almost all organic sistems because of their antiinflamatory and immunosupressive effects. They are used in perinatology to accelerate lungs maturation in expected premature labour. The most frequent used corticosteroids are bethamethason and dexamethason, with useful effects: acceleration of growth of fetal lungs by ripening pneumocites type II and supression of creating secundary septs; by protection of brain from intraventricular haemorrhage and periventricular leucomalation; decreasing rate of rethinopathy and enterocolitis and ductus artheriosus persistens. By this way the mortality rate ofpreterm newborns is decreased in 60% of cases. Expected harmful effects of antenatal using of corticosteroids are: high blood pressure of newborns in first 24 hours after delivery, the possible oedema of lungs, in simultaneous using of corticosteroids and bethamimetic treatment. It is not recommended to repeat treatment by corticosteroids in same pregnancy because of hormonal influence to fetal growth and neurological development, till clear benefit is not proved.
Fatusić
Zlatan
Z
Ginekolosko-akuserska klinika, Univerzitetski klinicki centar Tuzla.
D005260:Female; D005325:Fetal Organ Maturity / Q000187:drug effects*; D046128:Fetal Therapies; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000196:embryology*; D011247:Pregnancy
D005938:Glucocorticoids