title: Novel diarylsulfonylurea derivatives as potent antimitotic agents.
abstract: A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors.
authors.affiliation: LG Life Sciences, Ltd/R&D Park, 104-1 Moonji-dong, Yuseong-gu, Daejon 305-380, South Korea. semikim@lgls.co.kr
authors.forename: Semi
authors.initials: S
authors.lastname: Kim
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Koo
authors.forename: Jung In
authors.initials: JI
authors.lastname: Kim
authors.forename: Min-Hyeung
authors.initials: MH
authors.lastname: Kim
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Kiwon
authors.initials: K
authors.lastname: Jo
authors.forename: Hwan Geun
authors.initials: HG
authors.lastname: Choi
authors.forename: Sung Bae
authors.initials: SB
authors.lastname: Lee
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Jung
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013453:Sulfonylurea Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D050257:Tubulin Modulators
chemical_list: D000970:Antineoplastic Agents; D013453:Sulfonylurea Compounds; D050257:Tubulin Modulators; D004247:DNA