Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda.
It has recently been suggested that helminth infections may adversely influence susceptibility to other infections, including malaria. To investigate this hypothesis in a sub-Saharan African setting, surveys of helminth infections were conducted in 2003 among individuals who had been under weekly active case detection for clinical malaria during the preceding 18 months in four villages in Kabale District, southwest Uganda. Overall, 47.3% of individuals had at least one intestinal nematode species infection: hookworm, Ascaris lumbricoides and Trichuris trichiura were detected in 32.1, 17.4 and 8.1% of individuals, respectively. We found evidence of significant household clustering of A. lumbricoides, T. trichiura and hookworm, and clustering of heavy infection of each species. The association between helminth infection and clinical malaria was investigated in two villages and no evidence for an association was observed between the presence of infection or heavy infection and risk of malaria.
Shapiro
Adrienne E
AE
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Tukahebwa
Edridah M
EM
Kasten
Jennifer
J
Clarke
Siân E
SE
Magnussen
Pascal
P
Olsen
Annette
A
Kabatereine
Narcis B
NB
Ndyomugyenyi
Richard
R
Brooker
Simon
S
D000818:Animals; D001196:Ascariasis / Q000150:complications / Q000453:epidemiology / Q000469:parasitology; D017164:Ascaris lumbricoides / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D004198:Disease Susceptibility / Q000150:complications / Q000453:epidemiology / Q000469:parasitology; D005243:Feces / Q000469:parasitology; D005260:Female; D006373:Helminthiasis / Q000150:complications / Q000453:epidemiology* / Q000469:parasitology; D006725:Hookworm Infections / Q000150:complications / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008288:Malaria / Q000453:epidemiology* / Q000209:etiology / Q000469:parasitology; D008297:Male; D015995:Prevalence; D012423:Rural Health; D012959:Socioeconomic Factors; D014257:Trichuriasis / Q000150:complications / Q000453:epidemiology / Q000469:parasitology; D014258:Trichuris / Q000302:isolation & purification; D014454:Uganda / Q000453:epidemiology