title: Reducing the incidence of foot ulceration and amputation in diabetes.
abstract: Diabetes is a common disease that is associated with numerous complications, including foot ulceration and amputation. In diabetic patients, the incidence of foot ulcers ranges from 1.0% to 4.1%, and the incidence of lower-extremity amputations ranges from 2.1 to 13.7 per 1000. Risk factors for developing foot ulcers and subsequent amputation include neuropathy, peripheral vascular disease, and trauma. To reduce these complications, several preventive strategies have been devised, from reducing risk factors to improving treatment and management.
authors.affiliation: Department of Dermatology, University of Pennsylvania, 815 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA. dmargoli@cceb.med.upenn.edu
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Bartus
authors.forename: David J
authors.initials: DJ
authors.lastname: Margolis
mesh_terms: D000671:Amputation, Surgical / Q000706:statistics & numerical data*; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000517:prevention & control / Q000601:surgery; D017719:Diabetic Foot / Q000453:epidemiology* / Q000517:prevention & control / Q000601:surgery; D003929:Diabetic Neuropathies / Q000453:epidemiology / Q000517:prevention & control / Q000601:surgery; D016523:Foot Ulcer / Q000453:epidemiology* / Q000517:prevention & control / Q000601:surgery; D006801:Humans; D015994:Incidence; D012307:Risk Factors