Hypertension in obese patients: a dysmetabolic hypertension with a possible adipocyte dysfunction mechanism.
Large longitudinal studies showed the epidemiological link between obesity and hypertension. During last years, multiple possible mechanisms involved in this association were identified. Adipose tissue has an important role in the genesis of hypertension in obese patients through several pathways: insulin resistance, leptin, renin-angiotensin-aldosteron system and mediators of inflammation (TNF-alpha, IL-6). Adipocyte may be the major player in the development of insulin resistance and hypertension, elements of the metabolic syndrome, responsible for the cardiovascular complications.
Blaj
St
S
Internal Medicine I Department, Central Clinical Military Hospital 88, Mircea Vulcanescu Str., Bucharest, Romania.
Stanciu
S
S
Jurcut
C
C
Ciobîcă
L
L
D017667:Adipocytes / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology*; D020738:Leptin / Q000502:physiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology*; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000502:physiology
D016207:Cytokines; D020738:Leptin