Enteric-coated layered double hydroxides as a controlled release drug delivery system.
Layered double hydroxides (LDHs) or so-called anionic clays consist of cationic brucite-like layers and exchangeable interlayer anions. Because of their biocompatibility, these layered inorganic solids can be used as host materials to create drug-LDH host-guest supramolecular structures. Because of the basicity of LDHs however, LDHs as drug delivery system will be limited for use in the stomach where pH is 1.2. A core-shell material has been prepared therefore in this work. A non-steroidal anti-inflammatory drug, Fenbufen-intercalated LDHs as the core was coated with enteric polymers, Eudragit S 100 or Eudragit L 100 as a shell, giving a composite material which shows controlled release of the drug under in vitro conditions which model the passage of a material through the gastrointestinal tract.
Li
Bingxin
B
Ministry of Education Key Laboratory of Science and Technology of Controllable Chemical Reactions, Box 98, Beijing University of Chemical Technology, Beijing 100029, PR China.
He
Jing
J
Evans
David G
DG
Duan
Xue
X
D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000008:administration & dosage*; D010654:Phenylbutyrates / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility
D003692:Delayed-Action Preparations; D006878:Hydroxides; D010654:Phenylbutyrates; C010725:fenbufen