[Current status of MRI diagnostics with liver-specific contrast agents. Gd-EOB-DTPA and Gd-BOPTA].
The contrast agents Gd-EOB-DTPA and Gd-BOPTA can be administered by bolus injection and are appropriate for use in MRI both as vascularization markers and markers of hepatobiliary excretion. This contribution presents an overview of the specific characteristics of contrast media and the status of clinical development. In comparison to CT and to MRI with unspecific extracellular Gd-chelates, liver-specific contrast agents offer advantages in differentiating unclear liver lesions, increasing the detection rate, and examining the bile duct system.
Stroszczynski
C
C
Klinik und Poliklinik für Strahlenheilkunde, Campus-Virchow-Klinikum der Charité-Universitätsmedizin Berlin. stros@charite.de
Gaffke
G
G
Gnauck
M
M
Streitparth
F
F
Wieners
G
G
Lopez-Häninnen
E
E
D002614:Chelating Agents; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends*; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D010818:Practice Patterns, Physicians'; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D002614:Chelating Agents; D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA