title: PARK11 is not linked with Parkinson's disease in European families.
abstract: Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.
authors.affiliation: Hertie-Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler Str. 3, 72076 Tuebingen, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Prestel
authors.forename: Manu
authors.initials: M
authors.lastname: Sharma
authors.forename: Petra
authors.initials: P
authors.lastname: Leitner
authors.forename: Alexander
authors.initials: A
authors.lastname: Zimprich
authors.forename: Jenny R
authors.initials: JR
authors.lastname: Vaughan
authors.forename: Alexandra
authors.initials: A
authors.lastname: Dürr
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bonifati
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Michele
authors.forename: Hasmet A
authors.initials: HA
authors.lastname: Hanagasi
authors.forename: Matthew
authors.initials: M
authors.lastname: Farrer
authors.forename: Anne
authors.initials: A
authors.lastname: Hofer
authors.forename: Friedrich
authors.initials: F
authors.lastname: Asmus
authors.forename: Giampiero
authors.initials: G
authors.lastname: Volpe
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Meco
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Wood
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
mesh_terms: D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005060:Europe; D006801:Humans; D008126:Lod Score; D010300:Parkinson Disease / Q000235:genetics*; D044465:White People