title: Randomized controlled trial of effects of the airflow through the upper respiratory tract of intubated brain-injured patients on brain temperature and selective brain cooling.
abstract: BACKGROUND
  Pyrexia is common after brain injury; it is generally believed to affect outcome adversely and the usual clinical methods of reducing temperature are not effective. The normal physiological mechanisms of brain cooling are heat loss from the upper airways and through the skull, and these can produce selective brain cooling.
  
  
  METHODS
  Air at room temperature and humidity was continuously administered to 15 brain-injured, intubated and mechanically ventilated patients via a sponge-tipped oxygen catheter in each nostril at a combined rate of 115 ml kg(-1) min(-1). Brain temperature was measured using a pressure-temperature Camino catheter which is designed to site the thermistor 1 cm into the parenchyma in the frontal lobe. Oesophageal temperature was measured using an oesophageal stethoscope with a thermistor. After establishing baseline for 30 min, patients were randomized to receive airflow or no airflow for 6 h and then crossed over for a further 6 h.
  
  
  RESULTS
  Airflow replicating normal resting minute volume did not produce clinically relevant or statistically significant reductions in brain temperature [0.13 (SD 0.55) degrees C; 95% CI, 0.43-0.17 degrees C]. However, we serendipitously found some evidence of selective brain cooling via the skull, but this needs further substantiation.
  
  
  CONCLUSIONS
  A flow of humidified air at room temperature through the upper respiratory tracts of intubated brain-injured patients did not produce clinically relevant or statistically significant reductions in brain temperature measured in the frontal lobe.
authors.affiliation: Department of Anaesthesia, Intensive Care and Pain Management, University of Edinburgh, UK. p.andrews@ed.ac.uk
authors.forename: P J D
authors.initials: PJ
authors.lastname: Andrews
authors.forename: B
authors.initials: B
authors.lastname: Harris
authors.forename: G D
authors.initials: GD
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000388:Air; D001831:Body Temperature; D001833:Body Temperature Regulation; D001930:Brain Injuries / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D003422:Critical Care / Q000379:methods*; D018592:Cross-Over Studies; D005260:Female; D005334:Fever / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006813:Humidity; D007036:Hypothermia, Induced / Q000379:methods*; D007427:Intracranial Pressure; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial