Use of mitomycin C in the pediatric airway.
OBJECTIVE
Mitomycin C was not used in the field of otolaryngology before 1998. Currently it is commonly used by all pediatric otolaryngologists dealing with airway stenoses. Mitomycin C offers the surgeon a method of modifying healing and diminishing granulation tissue and cicatricial scar.


RESULTS
There are numerous animal studies showing the beneficial effect of mitomycin C on wound healing in the airway. The human studies rarely have controls and in many cases are case reports. Human studies typically use dosages commonly used in ophthalmology, which are in the low range in relation to the animal airway studies.


CONCLUSIONS
This article attempts to summarize the available research on mitomycin C, helping the clinical otolaryngologist choose the proper dosage, indications, and frequency of use.
Senders
Craig W
CW
Department of Otolaryngology, University of California Davis Medical Center, Sacramento, California 95817, USA. cwsenders@ucdavis.edu
D000818:Animals; D002648:Child; D006097:Granulation Tissue / Q000187:drug effects*; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D019651:Plastic Surgery Procedures; D012137:Respiratory System / Q000187:drug effects; D014135:Tracheal Stenosis / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects*
D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin