Elevated serum parathormone after Roux-en-Y gastric bypass.
BACKGROUND
Abnormalities in calcium and vitamin D metabolism are observed early after gastric bypass, whereas clinical or biochemical evidence of metabolic bone disease might not be detected until many years after the procedure. The aim of the present study was to evaluate the impact of bariatric surgery on bone metabolism determined on the basis of postoperative laboratory changes in calcium, phosphorus, magnesium, alkaline phosphatase and parathormone (PTH) levels.


METHODS
110 patients submitted to Roux-en-Y gastric bypass (RYGBP) were followed after surgery, and the following parameters were determined: intact PTH molecule (PTHi; chemiluminescence), alkaline phosphatase (colorimetric method), ionic calcium (selective electrode), phosphorus and magnesium (colorimetric method).


RESULTS
Elevated serum PTHi levels were observed in 29% of the patients and hypocalcemia in 0.9% from the 3rd postoperative month and afterwards (3 to 80 months after surgery).


CONCLUSIONS
There is a need for careful evaluation of bone metabolism and for routine calcium replacement after RYGBP.
Diniz
Maria de Fátima Haueisen Sander
Mde F
Serviço de Endocrinologia e Metabologia, Hospital das Clínicas da Universidade Federal de Minas Gerais, Av Alfredo Balena, 30130-100 Belo Horizonte, Minas Gerais, Brazil. mfhsdiniz@ufmg.br
Diniz
Marco Túlio Costa
MT
Sanches
Soraya Rodrigues Almeida
SR
Salgado
Patrícia Paz Cabral de Almeida
PP
Valadão
Maristane Mendes Andrade
MM
Araújo
Flávia Caldeira
FC
Martins
Daniele Siríaco
DS
Rocha
Alexandre Lages Savassi
AL
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D011184:Postoperative Period
D010281:Parathyroid Hormone; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium