Long-term intracerebral inflammatory response after traumatic brain injury.
Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.
Gentleman
S M
SM
Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Campus, London, UK. s.gentleman@imperial.ac.uk <s.gentleman@imperial.ac.uk>
Leclercq
P D
PD
Moyes
L
L
Graham
D I
DI
Smith
C
C
Griffin
W S T
WS
Nicoll
J A R
JA
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D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D001057:Apolipoproteins E; D015415:Biomarkers; D007375:Interleukin-1; D016177:Macrophage-1 Antigen; C067980:CD68 antigen, human; D000097382:CD68 Molecule