Photoinitiated DNA Binding by cis-[Ru(bpy)2(NH3)2]2+.
The ligand-loss photochemistry of cis-[Ru(bpy)(2)(NH(3))(2)](2+) (bpy = 2,2'-bipyridine) was investigated in water and in the presence of added ligands such as bipyridine and chloride. Irradiation of the complex results in the covalent binding to 9-methyl- and 9-ethylguanine, as well as to single-stranded and double-stranded DNA. This photoinduced DNA binding is not observed for the control complex [Ru(bpy)(2)(en)](2+) (en = ethylenediamine) under similar irradiation conditions. The results presented here show that octahedral Ru(II) complexes with photolabile ligands may prove useful as photoactivated cisplatin analogs.
Singh
Tanya N
TN
Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA.
Turro
Claudia
C
D015082:2,2'-Dipyridyl / Q000737:chemistry; D002713:Chlorine / Q000737:chemistry; D004247:DNA / Q000528:radiation effects*; D008024:Ligands; D009942:Organometallic Compounds / Q000737:chemistry*; D010777:Photochemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D008024:Ligands; D009942:Organometallic Compounds; D002713:Chlorine; D015082:2,2'-Dipyridyl; D012428:Ruthenium; D004247:DNA