A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population.
To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals. The frequency of the 77G allele in the control group was 1.1%, which was not significantly different from the 1.2% found in the patient group (P = 0.922). The C to G transversion does not seem to be associated with susceptibility for T1D.
Thude
H
H
Institute for Transfusion Medicine, University of Jena, Jena, Germany. hansjoerg.thude@med.uni-jena.de
Rosenhahn
S
S
Hunger-Dathe
W
W
Müller
U-A
UA
Barz
D
D
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005091:Exons; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics* / Q000276:immunology; D017354:Point Mutation; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017422:Sequence Analysis, DNA
D017493:Leukocyte Common Antigens; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1