Monodisperse chitosan nanoparticles for mucosal drug delivery.
Chitosan nanoparticles (CS NPs) of a controlled size (below 100 nm) and narrow size distribution were obtained through the process of ionic gelation between CS and sodium tripolyphosphate (TPP). A high degree of CS deacetylation and narrow polymer molecular weight distribution were demonstrated to be critical for the controlling particle size distribution. Properties of the CS NPs were examined at different temperatures, values of pH, and ratios of CS to TPP. The model protein, bovine serum albumin, was encapsulated into the NPs, and the in vitro release profiles were examined in physiologically relevant media at 37 degrees C.
Zhang
Hong
H
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
Oh
Megan
M
Allen
Christine
C
Kumacheva
Eugenia
E
D000818:Animals; D002417:Cattle; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D007477:Ions; D007700:Kinetics; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D009092:Mucous Membrane / Q000187:drug effects*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011122:Polyphosphates / Q000737:chemistry; D012709:Serum Albumin / Q000008:administration & dosage / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors
D007477:Ions; D011122:Polyphosphates; D012709:Serum Albumin; D048271:Chitosan; C005692:triphosphoric acid