title: The fluorescence of thyroid tissue.
abstract: OBJECTIVE
  To investigate the fluorescent characteristics of different thyroid tissues.
  
  
  METHODS
  Fresh ex vivo thyroid tissue was surfaced scanned with a fluorescence spectrophotometer. Resultant spectra were evaluated via interpeak ratios.
  
  
  RESULTS
  Interpeak ratios of all histologies were found to be significantly different from each other (P < 0.001). The diagnostic sensitivity and specificity of fluorescent spectroscopy was 86% and 91% for thyroid nodule capsule, 78% and 59% for papillary thyroid carcinoma, and 82% and 63% for normal thyroid, respectively.
  
  
  CONCLUSIONS
  Fluorescent spectroscopy can been used to identify significant differences in the fluorescent characteristics of various thyroid histologies.
  
  
  CONCLUSIONS
  This study is the first investigation of the fluorescence of thyroid tissue. The diagnostic ability of fluorescent spectrometry may allow it to be used as a localization aid for fine needle aspiration, using optical fiber probes. Further investigations may enhance the sensitivity and specificity of fluorescent spectrometry allowing it to replace or compliment fine needle aspiration.
  
  
  METHODS
  B-3.
authors.affiliation: Department of Otolaryngology, New York Eye and Ear Infirmary, New York, USA.
authors.forename: Michael Jay
authors.initials: MJ
authors.lastname: Pitman
authors.forename: Joshua Michael
authors.initials: JM
authors.lastname: Rosenthal
authors.forename: Howard E
authors.initials: HE
authors.lastname: Savage
authors.forename: Goupei
authors.initials: G
authors.lastname: Yu
authors.forename: Steven A
authors.initials: SA
authors.lastname: McCormick
authors.forename: Alvin
authors.initials: A
authors.lastname: Katz
authors.forename: Robert R
authors.initials: RR
authors.lastname: Alfano
authors.forename: Stimson Pryor
authors.initials: SP
authors.lastname: Schantz
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000473:pathology; D000465:Algorithms; D005453:Fluorescence; D006801:Humans; D013050:Spectrometry, Fluorescence; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology*; D016606:Thyroid Nodule / Q000473:pathology