title: FSH time-concentration profiles before and after administration of 0.25 mg cetrorelix in the gnRH-antagonist multiple-dose protocol for ovarian hyperstimulation.
abstract: OBJECTIVE
  To determine FSH concentration behavior before and after cetrorelix 0.25 mg administration in the GnRH-antagonist multiple-dose protocol on day 6 of ovarian stimulation with 150-300 IU daily recombinant FSH.
  
  
  METHODS
  Blood samples for FSH measurements were drawn from seven women every 15 min from 8 h prior to the first cetrorelix administration in the GnRH-antagonist multiple-dose protocol until 15-32 h thereafter.
  
  
  RESULTS
  No significant change of FSH concentration was observed.
  
  
  CONCLUSIONS
  This observation indicates that no rationale exists of increasing the daily FSH dosage concomitantly to the GnRH-antagonist administration to compensate for a drop of endogenous FSH.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Schleswig-Holstein, Campus Luebeck, 23538 Luebeck, Germany. georg.griesinger@frauenklinik.uni-luebeck.de
authors.forename: G
authors.initials: G
authors.lastname: Griesinger
authors.forename: D
authors.initials: D
authors.lastname: Finas
authors.forename: A
authors.initials: A
authors.lastname: Alisch
authors.forename: K
authors.initials: K
authors.lastname: Roiha
authors.forename: A
authors.initials: A
authors.lastname: Schultze-Mosgau
authors.forename: A K
authors.initials: AK
authors.lastname: Schröder
authors.forename: K
authors.initials: K
authors.lastname: Dafopoulos
authors.forename: K
authors.initials: K
authors.lastname: Diedrich
authors.forename: R
authors.initials: R
authors.lastname: Felberbaum
mesh_terms: D015415:Biomarkers / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*
chemical_list: D015415:Biomarkers; D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone; C062876:cetrorelix