Synthesis of arbutin by two-step reaction from glucose.
Arbutin was synthesized from glucose by two-step reaction below: (a) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl chloride or bromide was prepared by glucose and acetyl halide (chloride or bromide). (b) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl halide (Cl, Br) reacted with hydroquinone, methanol as solvent at pH=9.5-10.0.
Huang
Shen-Lin
SL
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Zhu
Yu-Lin
YL
Pan
Yuan-Jiang
YJ
Wu
Shi-Hua
SH
D000107:Acetylation; D001104:Arbutin / Q000138:chemical synthesis*; D001965:Bromides / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*
D001965:Bromides; D002712:Chlorides; D001104:Arbutin; D005947:Glucose