title: Successful desensitization to enfuvirtide after a hypersensitivity reaction in an HIV-1-infected man.
abstract: We report a case of successful, rapid desensitization to enfuvirtide after a hypersensitivity reaction in a man with highly drug-resistant human immunodeficiency virus type 1 infection. The patient was desensitized in a monitored intensive care unit and tolerated the rapid desensitization protocol without any serious adverse effects. This case illustrates the ability to safely desensitize patients with limited treatment options who require enfuvirtide therapy.
authors.affiliation: Division of Infectious Diseases, Thomas Jefferson University, Philadelphia, PA 19107, USA. joseph.desimone@jefferson.edu
authors.forename: Joseph A
authors.initials: JA
authors.lastname: DeSimone
authors.forename: Ambrish
authors.initials: A
authors.lastname: Ojha
authors.forename: Rolee
authors.initials: R
authors.lastname: Pathak
authors.forename: John
authors.initials: J
authors.lastname: Cohn
mesh_terms: D000328:Adult; D004342:Drug Hypersensitivity / Q000628:therapy*; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41 / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D023581:HIV Fusion Inhibitors / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D012074:Remission Induction
chemical_list: D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010446:Peptide Fragments; D000077560:Enfuvirtide