title: Prothrombin 20210A and oral contraceptive use as risk factors for cerebral venous thrombosis.
abstract: BACKGROUND
  This study investigates the association between cerebral vein thrombosis (CVT) and the mutations FV 1691A (factor V Leiden), PT 20210A and MTHFR 677TT and acquired factors including oral contraceptive (OC) use.
  
  
  METHODS
  26 patients (21 females) and 217 healthy controls (134 females) were studied. Multiple regression analysis was performed.
  
  
  RESULTS
  The frequency of the three mutations in cases and controls were: PT 20210A, 23 versus 1%, odds ratio (OR) 21.40 (95% CI 4.29-118.75), p < 0.001; FV 1691A, 8 versus 1%, OR 5.94 (95% CI 0.66-46.9); MTHFR 677TT, 4 versus 7%, OR 0.54 (95% CI 0.03-4.08). OC use was more frequent in female patients over 14 years old than in controls (84 vs. 40%, OR 8.15, 95% CI 2.09-37.13, p < 0.001). The model that best explained the thrombotic risk included PT 20210A and OC use.
  
  
  CONCLUSIONS
  PT 20210A and OC use are the main thrombophilic risk factors predisposing to CVT and should be routinely investigated in patients with this disease.
authors.affiliation: Hematology, Department of Internal Medicine, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, RJ 21941-590, Brazil. telma@hucff.ufrj.br
authors.forename: Telma
authors.initials: T
authors.lastname: Gadelha
authors.forename: Charles
authors.initials: C
authors.lastname: André
authors.forename: Andreza A V
authors.initials: AA
authors.lastname: Jucá
authors.forename: Márcio
authors.initials: M
authors.lastname: Nucci
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D020767:Intracranial Thrombosis / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000453:epidemiology / Q000235:genetics
chemical_list: D003278:Contraceptives, Oral, Hormonal; D011516:Prothrombin