Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus without symptoms of depression.
This clinical study compared the expression of circulating proinflammatory (tumor necrosis factor-alpha [TNF-alpha] and interleukin-6) and anti-inflammatory (interleukin-10) cytokines and soluble apoptosis mediators (Fas/Fas ligand) between patients with stable chronic heart failure and depressive symptoms (as estimated by the Zung Self-Rating Depression Scale) (n = 15) and those without these symptoms (n = 20). Patients with depressive symptoms exhibited significantly higher levels of TNF-alpha and soluble Fas ligand, as well as significantly lower levels of interleukin-10, than patients without emotional distress. A disregulated cytokine network and activated apoptosis signaling molecules may be actively implicated in the pathophysiology of chronic emotional distress and depressive symptoms in patients with heart failure.
Parissis
John T
JT
Heart Failure Clinic, Amalia Fleming Hospital, Athens, Greece. jparissis@yahoo.com <jparissis@yahoo.com>
Adamopoulos
Stamatis
S
Rigas
Antonios
A
Kostakis
George
G
Karatzas
Dimitrios
D
Venetsanou
Koula
K
Kremastinos
Dimitrios Th
DT
D000368:Aged; D017209:Apoptosis; D003863:Depression / Q000097:blood / Q000150:complications*; D053222:Fas Ligand Protein; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D019014:fas Receptor / Q000097:blood
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D018836:Inflammation Mediators; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D016753:Interleukin-10