[Clinical use of haematopoietic stem cells from cord blood].
A group of experts appointed by the Norwegian Centre for Health Technology Assessment (SMM) has undertaken a systematic review of available literature on the clinical effectiveness of transplanting haematopoietic stem cells from cord blood. A total of 17 studies form the documentary basis of the review. Autologous transplants of stem cells from cord blood have not been published. Retrospective studies suggest that the clinical effect of allogeneic cord blood transplants, at least in children, is comparable to transplants with allogeneic stem cells from bone marrow or peripheral blood cells. This review demonstrates the need for prospective studies comparing transplantations of cord blood with bone marrow or peripheral blood stem cells.
Lyngstadaas
Anita
A
Senter for medisinsk metodevurdering SINTEF Unimed Postboks 124 Blindern 0314 Oslo anita.lyngstadaas@kunnskapssenteret.no.
Husebekk
Anne
A
Funderud
Steinar
S
Brinch
Lorentz
L
D000328:Adult; D002648:Child; D015331:Cohort Studies; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D012189:Retrospective Studies