title: Successful human ovarian autotransplantation to the upper arm.
abstract: In young patients with cervical carcinoma, the standard surgical treatment is often followed by postoperative radiotherapy. This treatment strategy, although resulting in a significant increase in cure rates, often causes infertility and premature ovarian failure. Ovarian autotransplantation outside the field of radiotherapy is a new technique to preserve gonadal function. One ovary was transplanted to the left upper arm during the surgical treatment for cervical carcinoma. Vascular anastomoses were performed by microsurgery. After transplantation, the ovary showed adequate arterial and venous blood flow. By clinical examination and ultrasound monitoring, the ovarian cycles remained regular and follicle growth occurred normally for > 1 year. Heterotopic autotransplantation of the ovary to the upper arm is a promising surgical technique to maintain the ovarian function in women who become menopausal due to cancer treatment regimens.
authors.affiliation: Department of Gynaecology, Leiden University Medical Center, The Netherlands. hilders@rdgg.nl
authors.forename: Carina G
authors.initials: CG
authors.lastname: Hilders
authors.forename: Andrzej G
authors.initials: AG
authors.lastname: Baranski
authors.forename: Lex
authors.initials: L
authors.lastname: Peters
authors.forename: Andre
authors.initials: A
authors.lastname: Ramkhelawan
authors.forename: J Baptist
authors.initials: JB
authors.lastname: Trimbos
mesh_terms: D000328:Adult; D001132:Arm / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007247:Infertility, Female / Q000517:prevention & control; D010053:Ovary / Q000637:transplantation*; D016649:Primary Ovarian Insufficiency / Q000517:prevention & control; D014182:Transplantation, Autologous; D016042:Transplantation, Heterotopic / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*