title: Clinical considerations concerning progressive diabetic renal diseases. Severe complications of early onset diabetes mellitus.
abstract: The main question of diabetic nephropathy in early onset diabetes mellitus consists of the possibility to advance to chronic renal failure at an early age, a complication having severe consequences in medical, familial and socio-economic life. The authors of this study are purposing to discover risk factors involved in the evolution of diabetic nephropathy (DN) with the aim to act by tertiary and secondary prophylactic measures which will decrease or stop the evolution of final forms of this disease. Our study contains 129 patients with insulino-dependent diabetes mellitus (type 1), which started under twenty years age, screened between 1965-2000. The average age is 21 years and the average age of disease's onset is 12 years. We used Mogensen's classification in order to border the DN. The study refers only to the patent DN, called "OVERT-DN", which represents the fourth and the fifth stages. High arterial blood pressure values were taken into consideration when these are higher than 130/85 Hg mm. The informations were statistically analysed. DN affects 21% from the lot of 129 patients. We noticed differences between males and females from 80 type 1 DM males, 23.7% had DN and from 49 type 1 DM females 16.3% had DN. High arterial blood pressure appeared to 19.3% from all patients and as a secondary effect of DN in 18.6% of the cases; "border-line" essential high arterial blood pressure was found in only one patient. From the 27 patients with clinic DN, 44.4% evoluated to chronic renal failure (CRF) and half of them suffered till final stage of CRF. The frequency of DN was linked with the duration of diabetes. Thus, DN affects 13.8% of patients with 6-10 years of illness; 54.5 of patients with 20 years of illness, and after 25 years of illness - 87.5%. After 23 years of diabetes, it was accounted mortality in 3 of 7 cases, caused by final CRF.
authors.affiliation: University of Medicine and Pharmacy, Craiova.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Corniţescu
authors.forename: Maria
authors.initials: M
authors.lastname: Moţa
authors.forename: E
authors.initials: E
authors.lastname: Moţa
authors.forename: Ligia
authors.initials: L
authors.lastname: Stănescu
mesh_terms: D017668:Age of Onset; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000453:epidemiology* / Q000503:physiopathology; D018450:Disease Progression; D012307:Risk Factors