Novel diarylsulfonylurea derivatives as potent antimitotic agents.
A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors.
Kim
Semi
S
LG Life Sciences, Ltd/R&D Park, 104-1 Moonji-dong, Yuseong-gu, Daejon 305-380, South Korea. semikim@lgls.co.kr
Park
Ji Hyun
JH
Koo
Sun-Young
SY
Kim
Jung In
JI
Kim
Min-Hyeung
MH
Kim
Ji Eun
JE
Jo
Kiwon
K
Choi
Hwan Geun
HG
Lee
Sung Bae
SB
Jung
Sang-Hun
SH
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013453:Sulfonylurea Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D050257:Tubulin Modulators
D000970:Antineoplastic Agents; D013453:Sulfonylurea Compounds; D050257:Tubulin Modulators; D004247:DNA