Adverse reactions to selective cyclooxygenase-2 inhibitors (coxibs).
Coxibs, selective inhibitors of arachidonic acid cyclooxygenase-2, constitute a new, clinically useful therapeutic class of drugs that possess analgesic, antiinflammatory, and antipyretic properties. The drug inserts of prescription information presently provide a warning contraindicating their use in patients with aspirin-intolerant asthma and aspirin and NSAID hypersensitivity. However, according to investigations reported until now, most of those NSAID-sensitive individuals will tolerate coxibs. Careful oral challenge is useful for patient management since some cutaneous and systemic reactions of hypersensitivity, especially when sulfonamide-containing coxibs are employed, may occur.
Sánchez-Borges
Mario
M
Allergy and Clinical Immunology Service, Centro Médico-Docente La Trinidad, Caracas, Venezuela. malsan@cantv.net
Capriles-Hulett
Arnaldo
A
Caballero-Fonseca
Fernan
F
D001241:Aspirin / Q000009:adverse effects; D002986:Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects* / Q000494:pharmacology; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D012120:Respiration Disorders / Q000150:complications*
D016861:Cyclooxygenase Inhibitors; D001241:Aspirin