Synthesis of phosphonic analogues of carnitine and gamma-amino-beta-hydroxybutyric acid.
The involvement of carnitine and gamma-amino-beta-hydroxybutyric acid in the biology of mammalian cells, the physiology of the human body, and some important aspects of medicinal treatment has induced many research groups to develop their pharmacologically potent analogues. Among them are the very important phosphonic analogues: phosphocarnitine and gamma-amino-beta-hydroxypropylphosphonic acid. This mini-review describes the various methodologies used for the synthesis of these compounds.
Tadeusiak
Elzbieta J
EJ
Department of Structural Studies, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland. elatad@bilbo.cbmm.lodz.pl
D002331:Carnitine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008968:Molecular Conformation; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D063065:Organophosphonates; C485025:phosphocarnitine; C004480:4-amino-3-hydroxybutyric acid; D005680:gamma-Aminobutyric Acid; D002331:Carnitine