title: Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease.
abstract: Chronic disabilities in multiple sclerosis are believed to be due to neuron damage and degeneration, which follow remyelination failure. Due to the presence of numerous oligodendrocyte precursors inside demyelination plaques, one reason for demyelination failure could be the inability of oligodendrocyte precursor cells to turn into myelinating oligodendrocytes. In this study, we show that thyroid hormone enhances and accelerates remyelination in an experimental model of chronic demyelination, i.e., experimental allergic encephalomyelitis in congenic female Dark Agouti rats immunized with complete guinea pig spinal cord. Thyroid hormone, when administered during the acute phase of the disease, increases expression of platelet-derived growth factor alpha receptor, restores normal levels of myelin basic protein mRNA and protein, and allows an early and morphologically competent reassembly of myelin sheaths. Moreover, thyroid hormone exerts a neuroprotective effect with respect to axonal pathology.
authors.affiliation: Department of Veterinary Morphophysiology and Animal Production, University of Bologna, 40064 Ozzano Emilia, Bologna, Italy.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Fernandez
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giuliani
authors.forename: Stefania
authors.initials: S
authors.lastname: Pirondi
authors.forename: Giulia
authors.initials: G
authors.lastname: D'Intino
authors.forename: Luciana
authors.initials: L
authors.lastname: Giardino
authors.forename: Luigi
authors.initials: L
authors.lastname: Aloe
authors.forename: Rita
authors.initials: R
authors.lastname: Levi-Montalcini
authors.forename: Laura
authors.initials: L
authors.lastname: Calzà
mesh_terms: D000818:Animals; D020278:Demyelinating Autoimmune Diseases, CNS / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000473:pathology; D004676:Myelin Basic Protein / Q000235:genetics / Q000378:metabolism; D009186:Myelin Sheath / Q000187:drug effects / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000276:immunology; D013974:Thyroxine / Q000008:administration & dosage*
chemical_list: D004676:Myelin Basic Protein; D012333:RNA, Messenger; D013974:Thyroxine