title: Signaling pathways in Th2 development.
abstract: In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Kerri A
authors.initials: KA
authors.lastname: Mowen
authors.forename: Laurie H
authors.initials: LH
authors.lastname: Glimcher
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D003713:Dendritic Cells / Q000502:physiology; D004064:Digestive System / Q000469:parasitology; D006801:Humans; D051379:Mice; D015398:Signal Transduction / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000502:physiology*; D018418:Th2 Cells / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology
chemical_list: D016207:Cytokines; D014157:Transcription Factors