Brd4: tethering, segregation and beyond.
Papillomaviruses segregate their genomes in dividing cells by tethering them to mitotic chromosomes via the viral E2 protein. A recent report has shown that this interaction is mediated by the cellular bromodomain protein Brd4. This discovery provides new insight into the mechanism of viral genome segregation and raises many exciting questions about the regulation and nature of the interaction of this complex with mitotic chromosomes.
McBride
Alison A
AA
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. amcbride@nih.gov
McPhillips
Maria G
MG
Oliveira
Jaquelline G
JG
D000818:Animals; D020090:Chromosome Segregation / Q000502:physiology*; D002875:Chromosomes / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D008938:Mitosis; D027383:Papillomaviridae / Q000378:metabolism / Q000502:physiology*; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication
D004268:DNA-Binding Proteins; C051550:E2 protein, Bovine papillomavirus; D014764:Viral Proteins