title: DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis.
abstract: Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed into Talairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.
authors.affiliation: Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA. Hoptman@nki.rfmh.org
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hoptman
authors.forename: Babak A
authors.initials: BA
authors.lastname: Ardekani
authors.forename: Pamela D
authors.initials: PD
authors.lastname: Butler
authors.forename: Jay
authors.initials: J
authors.lastname: Nierenberg
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Javitt
authors.forename: Kelvin O
authors.initials: KO
authors.lastname: Lim
mesh_terms: D000328:Adult; D016880:Anisotropy; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007175:Impulsive Behavior / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications / Q000473:pathology*