title: Multiple gestation and infertility treatment: registration, reflection and reaction--the Belgian project.
abstract: Multiple pregnancies associated with infertility treatment are recognized as an adverse outcome and are responsible for morbidity and mortality related to prematurity and very low birthweight population. Due to the epidemic of iatrogenic multiple births, the incidence of maternal, perinatal and childhood morbidity and mortality has increased. This results in a hidden healthcare cost of infertility therapy and this may lead to social and political concern. Reducing the number of embryos transferred and the use of natural cycle IVF will surely decrease the number of multiple gestations. Consequently, optimized cryopreservation programmes will be essential. For non-IVF hormonal stimulation, responsible for more than one-third of all multiple pregnancies after infertility treatment, a strict ovarian stimulation protocol aiming at mono-ovulation is crucial. Multifetal pregnancy reduction is an effective method to reduce high order multiplets but carries its own risk of medical and emotional complications. Excellent data collection of all infertility treatments is needed in our discussion with policy makers. The Belgian project, in which reimbursement of assisted reproduction technology-related laboratory activities is linked to a transfer policy aiming at substantial multiple pregnancy reduction, is a good example of cost-efficient health care through responsible, well considered clinical practice.
authors.affiliation: Genk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, Genk, Belgium. willem.ombelet@pandora.be
authors.forename: Willem
authors.initials: W
authors.lastname: Ombelet
authors.forename: Petra
authors.initials: P
authors.lastname: De Sutter
authors.forename: Josiane
authors.initials: J
authors.lastname: Van der Elst
authors.forename: Guy
authors.initials: G
authors.lastname: Martens
mesh_terms: D001530:Belgium; D015925:Cryopreservation; D004624:Embryo Transfer / Q000009:adverse effects / Q000639:trends; D004622:Embryo, Mammalian / Q000502:physiology; D005260:Female; D006078:Government Programs; D006291:Health Policy; D006801:Humans; D007231:Infant, Newborn; D007246:Infertility / Q000628:therapy*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D011256:Pregnancy Outcome; D018607:Pregnancy Reduction, Multifetal / Q000379:methods / Q000523:psychology; D011272:Pregnancy, Multiple; D027724:Reproductive Techniques, Assisted / Q000191:economics