title: Effect of environmental hyperthermia on gastrin, somatostatin and motilin in rat ulcerated antral mucosa.
abstract: OBJECTIVE
  To study the effect of environmental hyperthermia on gastrin, somatostatin and motilin in rat ulcerated antral mucosa.
  
  
  METHODS
  Forty-two Wistar rats were equally divided into six groups, according to the room temperature (high and normal) and the treatment (acetic acid, normal saline and no treatment). Levels of gastrin, somatostatin and motilin in rat ulcerated antral mucosa were measured with a radioimmunoassay method.
  
  
  RESULTS
  The average temperature and humidity were 32.5 degrees and 66.7% for the high temperature group, and 21.1 degrees and 49.3% for the normal temperature group, respectively. Gastric ulcer model was successfully induced in rat injected with 0.05 mL acetic acid into the antrum. In rats with gastric ulcers, the levels of gastrin and motilin increased, whereas the somatostatin level declined in antral mucosa, compared with those in rats treated with normal saline and the controls. However, the change extent in the levels of gastrin, motilin and somatostatin in antral mucosa was less in the high temperature group than in the normal temperature group.
  
  
  CONCLUSIONS
  The levels of gastrin, somatostatin and motilin in rat ulcerated antral mucosal tissue remain relatively stable in a high temperature environment, which may relate to the equilibration of the dynamic system.
authors.affiliation: Department of Gastroenterology, Nanfang Hospital, First Military medical University, Guangzhou 510515, Guangdong Province, China. phd@china.com
authors.forename: Feng-Peng
authors.initials: FP
authors.lastname: Sun
authors.forename: Yu-Gang
authors.initials: YG
authors.lastname: Song
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D004777:Environment; D005334:Fever / Q000150:complications / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D006358:Hot Temperature; D008297:Male; D009037:Motilin / Q000378:metabolism*; D011706:Pyloric Antrum / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism*; D013276:Stomach Ulcer / Q000150:complications / Q000378:metabolism*
chemical_list: D005755:Gastrins; D013004:Somatostatin; D009037:Motilin