title: Cellular and physiological effects of short-chain fatty acids.
abstract: Short chain fatty acids (SCFA) have multiple in vivo and in vitro effects including cell cycle arrest and induction of protein synthesis, differentiation, and apoptosis. Butyrate or derivatives have promise for treating inflammatory bowel disease and colon cancer. Genomic and proteomic analysis have generated new knowledge on function and applications for SCFA.
authors.affiliation: Clarian Health Partners, Inc, 1812 N Capital Ave Indianapolis, IN 46202, USA. smiller@clarian.org
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Miller
mesh_terms: D000818:Animals; D002087:Butyrates / Q000378:metabolism / Q000494:pharmacology; D005232:Fatty Acids, Volatile / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D013927:Thrombosis / Q000209:etiology / Q000628:therapy
chemical_list: D002087:Butyrates; D005232:Fatty Acids, Volatile