A general palladium-catalyzed coupling of aryl bromides/triflates and thiols.
We have developed an efficient palladium-catalyzed carbon-sulfur bond formation reaction of aryl bromides, triflates, and activated aryl chloride. Using this protocol, we have shown tolerance to a wide variety of aryl thiols and alkyl thiols that can also be used as sulfide equivalents. [reaction: see text]
Itoh
Takahiro
T
Process Research, Process R & D, Banyu Pharmaceutical Co. Ltd., 9-1 Kamimutsuna 3-Chome, Okazaki, Aichi 444-0858, Japan. takahiro_itoh@merck.com
Mase
Toshiaki
T