title: Asymmetric synthesis of cis-5-substituted pyrrolidine 2-phosphonates using metal carbenoid NH insertion and delta-amino beta-ketophosphonates.
abstract: Cis-5-substituted pyrrolidine phosphonates, proline surrogates, are prepared by a highly stereoselective intramolecular metal carbenoid N-H insertion from a sulfinimine-derived delta-amino alpha-diazo beta-ketophosphonate. [reaction: see text]
authors.affiliation: Department of Chemistry, Temple University, Philadelphia, PA 19122, USA. fdavis@temple.edu
authors.forename: Franklin A
authors.initials: FA
authors.lastname: Davis
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Wu
authors.forename: He
authors.initials: H
authors.lastname: Xu
authors.forename: Junyi
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000737:chemistry; D008670:Metals; D063065:Organophosphonates / Q000138:chemical synthesis*; D011759:Pyrrolidines / Q000138:chemical synthesis*
chemical_list: D000588:Amines; D008670:Metals; D063065:Organophosphonates; D011759:Pyrrolidines