Design considerations in the sequential analysis of matched case-control data.
A role for sequential test procedures is emerging in genetic and epidemiological studies using banked biological resources. This stems from the methodology's potential for improved use of information relative to comparable fixed sample designs. Studies in which cost, time and ethics feature prominently are particularly suited to a sequential approach. In this paper sequential procedures for matched case-control studies with binary data will be investigated and assessed. Design issues such as sample size evaluation and error rates are identified and addressed. The methodology is illustrated and evaluated using both real and simulated data sets.
Baksh
M Fazil
MF
Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK. f.baksh@imperial.ac.uk
Todd
Susan
S
Whitehead
John
J
Lucini
María M
MM
D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D015340:Epidemiologic Research Design; D005260:Female; D006801:Humans; D008327:Mammography; D009426:Netherlands / Q000453:epidemiology; D012189:Retrospective Studies; D018401:Sample Size