title: Nanoporous SiC: a candidate semi-permeable material for biomedical applications.
abstract: We have fabricated free-standing SiC nanoporous membranes in both p -type and n -type material. We showed that these membranes will permit the diffusion of proteins up to 29000 Daltons, while excluding larger proteins. By using radioactively labeled albumin, we also show that porous SiC has very low protein adsorption, comparable to the best commercially available polymer nanoporous membrane.
authors.affiliation: Molecular Biosensors and Imaging Center, Carnegie Mellon University, Pittsburgh, PA 15213, USA. alan2@andrew.cmu.edu
authors.forename: A J
authors.initials: AJ
authors.lastname: Rosenbloom
authors.forename: D M
authors.initials: DM
authors.lastname: Sipe
authors.forename: Y
authors.initials: Y
authors.lastname: Shishkin
authors.forename: Y
authors.initials: Y
authors.lastname: Ke
authors.forename: R P
authors.initials: RP
authors.lastname: Devaty
authors.forename: W J
authors.initials: WJ
authors.lastname: Choyke
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D001698:Biomedical Engineering / Q000295:instrumentation / Q000379:methods; D017554:Carbon Compounds, Inorganic / Q000032:analysis / Q000737:chemistry*; D008422:Materials Testing; D008567:Membranes, Artificial; D049329:Nanostructures / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D010539:Permeability; D016062:Porosity; D011506:Proteins / Q000302:isolation & purification*; D017655:Silicon Compounds / Q000032:analysis / Q000737:chemistry*; D013499:Surface Properties; D014462:Ultrafiltration / Q000295:instrumentation* / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D017554:Carbon Compounds, Inorganic; D008567:Membranes, Artificial; D011506:Proteins; D017655:Silicon Compounds; C022088:silicon carbide