Use of N-N bond stereodynamics in ring-closing metathesis to form medium-sized rings and macrocycles.
A unique strategy based on double ring-closing metathesis for the formation of a 14-membered macrocyclic enamide has been developed. This strategy hinges upon the well-known stereodynamic and conformational behavior of N-substituted diacylhydrazines, which promotes an effective ring-closing metathesis of hydrazine-derived dienes and enynes to form 8- to 14-membered rings.
Kim
Yi Jin
YJ
Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Lee
Daesung
D
D003500:Cyclization; D009584:Nitrogen / Q000737:chemistry*; D013237:Stereoisomerism
D009584:Nitrogen