title: Effects of two P/S ratios with same peroxidizability index value and antioxidants supplementation on serum lipid concentration and hepatic enzyme activities of rats.
abstract: BACKGROUND
  High polyunsaturated/saturated fatty acid (P/S) ratio of diet decreases the risk of cardiovascular disease (CVD) with improvement of serum lipid profiles and inhibition of lipid peroxidation. This study was to investigate the effects of P/S ratio and antioxidants supplementation on lipid and peroxidation when dietary peroxidizability index (PI) value was the same.
  
  
  METHODS
  Female Sprague-Dawley rats weighing 100-120 g were fed four different experimental diets for 4 weeks. The P/S ratios were 0.38 (LP) and 4.81 (HP) when the PI value of diet was 81.22. These diets were supplemented with vitamin E 1000 mg/kg diet and selenium 2.5 mg/kg diet (LPS and HPS).
  
  
  RESULTS
  The total-cholesterol (T-C) and HDL-cholesterol concentrations of serum were higher in HP and HPS (p<0.001). The cardiac index and atherogenic index were lower in HP and HPS (p<0.001). Hepatic thiobarbituric acid reactive substance concentrations were higher in LP and LPS (p<0.001). However, P/S ratio and antioxidants had no effect on antioxidant enzyme activities in the liver.
  
  
  CONCLUSIONS
  A high P/S ratio diet has a beneficial effect on CVD risk even without antioxidant when the PI value is the same. We suggest that P/S ratio as well as PI value should be considered for reducing the risk of CVD.
authors.affiliation: Department of Food and Nutrition, Hanyang University, Seoul 133-791, South Korea.
authors.forename: Min Jeong
authors.initials: MJ
authors.lastname: Kang
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Lee
authors.forename: Sang Sun
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000032:analysis / Q000378:metabolism*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000201:enzymology*; D009821:Oils / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D008055:Lipids; D009821:Oils