title: Correlation of histopathological variants, cellular DNA content, and clinical outcome in adenoid cystic carcinoma of the salivary glands.
abstract: OBJECTIVE
  To study the correlation between flow cytometrically measured DNA ploidy with prognostically important histopathologic groups and clinical outcome in patients with adenoid cystic carcinoma of the salivary glands.
  
  
  METHODS
  46 tumor specimens were analyzed flow cytometrically for DNA content and assessed for histological grade. Correlations were made between tumor DNA ploidy and histopathological grade, and disease-free and overall survival of these patients.
  
  
  RESULTS
  Of the 46 patients, 31 had a cribiform/tubular histologic pattern, and 15 had a solid pattern. 84% of the tumors with cribriform/tubular pattern were DNA diploid, compared with 33% of tumors that were graded solid. This difference proved to be statistically significant (chi(2)11.75, P = 0.0006). Overall and disease-free survival periods were longer for patients with DNA diploid tumors in both groups, 63% vs. 36% and 62% vs 38%, respectively.
  
  
  CONCLUSIONS
  Tumor DNA ploidy correlates with prognostically important tumor histopathology as well as overall and disease-free survival in patients with adenoid cystic carcinoma of the salivary gland.
  
  
  METHODS
  B-3.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
authors.forename: Ileana
authors.initials: I
authors.lastname: Enamorado
authors.forename: Raam
authors.initials: R
authors.lastname: Lakhani
authors.forename: Hakan
authors.initials: H
authors.lastname: Korkmaz
authors.forename: George H
authors.initials: GH
authors.lastname: Yoo
authors.forename: Maria
authors.initials: M
authors.lastname: Del Mar Alonso
authors.forename: Haline
authors.initials: H
authors.lastname: Pietraszkiewicz
authors.forename: Zosia
authors.initials: Z
authors.lastname: Maciorowski
authors.forename: Harold
authors.initials: H
authors.lastname: Kim
authors.forename: Omer
authors.initials: O
authors.lastname: Kucuk
authors.forename: John R
authors.initials: JR
authors.lastname: Jacobs
authors.forename: John F
authors.initials: JF
authors.lastname: Ensley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D004247:DNA / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D004247:DNA