title: Preparation of 5-hydroxy-1-alkenyboronates from 1-alkynylboronates, Cp2ZrCl2/2EtMgBr, and aldehydes.
abstract: 1-Alkynylboronates form five-membered zirconacycles with Cp(2)ZrCl(2)/2-EtMgBr as indicated by deuterium labeling. The zirconacycles add aldehydes to form seven-membered zirconacycles. Hydrolysis of the latter provides 5-hydroxy-1-alkenylboronates in fair to good isolated yields. Both aliphatic and aromatic aldehydes undergo insertion.
authors.affiliation: Department of Natural Products and Medicinal Chemistry, School of Pharmacy, Hebrew University in Jerusalem, Jerusalem 91120, Israel.
authors.forename: Abed Al
authors.initials: AA
authors.lastname: Aziz Quntar
authors.forename: Morris
authors.initials: M
authors.lastname: Srebnik