title: Electron transfer rates in DNA films as a function of tether length.
abstract: A homologous series of DNA-modified electrodes has been investigated in which the molecular tether length varies. Using intercalated, covalently bound daunomycin as a redox probe, an exponential dependence of electron transfer rates on the number of intervening methylene groups in the sigma-bonded tether is observed. In contrast, variation in DM position within DNA yields no detectable change in rate. These data confirm that overall electron transfer rates in DNA films are limited by the tether, not the DNA.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
authors.forename: T Gregory
authors.initials: TG
authors.lastname: Drummond
authors.forename: Michael G
authors.initials: MG
authors.lastname: Hill
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: Barton
mesh_terms: D004247:DNA / Q000737:chemistry*; D003630:Daunorubicin / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods; D004583:Electrons; D007700:Kinetics; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
chemical_list: D004247:DNA; D003630:Daunorubicin