title: Angiographic and three-dimensional intravascular ultrasound analysis of combined intracoronary beta radiation and self-expanding stent implantation in human coronary arteries.
abstract: This study tested the combination of vascular brachytherapy (VBT) and self-expanding Wallstent implantation in coronary lesions of patients at high risk for restenosis as assessed angiographically by quantitative coronary analysis and by 3-dimensional intravascular ultrasound analysis. Twenty-nine "de novo" lesions were managed with a self-expanding stent alone (n = 19) or with a self-expanding stent after beta-VBT (n = 10) in 27 patients who had been identified by high levels of plasma angiotensin-converting enzyme as being prone to myointimal growth after stent implantation. At 6 months, the increase in stent strut diameter was similar in the 2 groups by quantitative coronary analysis and 3-dimensional intravascular ultrasound (Delta mean stent strut diameter -0.33 +/- 0.3 vs -0.40 +/- 0.3 mm, p = 0.5; Delta stent area -11.8 +/- 6.1 vs -12.0 +/- 6.1 mm(2), p = 0.9; Delta stent volume -96.9 +/- 112 vs -83.5 +/- 73 mm(3), p = 0.7; for groups treated with VBT and self-expanding stents and only self-expanding stents, respectively). In-stent neointimal proliferation was decreased in the group treated with VBT and self-expanding stents (minimal luminal diameter 2.5 +/- 0.8 vs 1.88 +/- 0.8 mm, p = 0.04) by quantitative coronary analysis (minimal luminal area 6.7 +/- 2.5 vs 4.1 +/- 1.9 mm(2), p = 0.01), by intravascular ultrasound, and proliferation volume (84.6 +/- 66.4 vs 159.2 +/- 103.5 mm(3), p = 0.05) by 3-dimensional intravascular ultrasound. Positive vessel and luminal remodelings were observed in 50% of the group treated with VBT and self-expanding stents and in 11% of the group treated only with self-expanding stents (p = 0.02). The combined use of VBT and self-expanding stents is a novel approach that enlarges vascular lumen by preventing vessel constriction and neointimal proliferation. The feasibility and good results of this experimental approach suggest that the simultaneous use of these 2 technologies may be an interesting alternative for difficult vascular districts with high restenosis rates, such as peripheral circulation in the lower limbs.
authors.affiliation: Catheterization Laboratory of the Università del Piemonte Orientale, Ospedale Maggiore della Carità, Novara, Italy. valeria_ferrero@hotmail.com <valeria_ferrero@hotmail.com>
authors.forename: Valeria
authors.initials: V
authors.lastname: Ferrero
authors.forename: Flavio
authors.initials: F
authors.lastname: Ribichini
authors.forename: Guy R
authors.initials: GR
authors.lastname: Heyndrickx
authors.forename: Bernard
authors.initials: B
authors.lastname: De Bruyne
authors.forename: Marleen
authors.initials: M
authors.lastname: Piessens
authors.forename: Stéphane
authors.initials: S
authors.lastname: Carlier
authors.forename: Martin
authors.initials: M
authors.lastname: Büchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Matullo
authors.forename: Corrado
authors.initials: C
authors.lastname: Vassanelli
authors.forename: William
authors.initials: W
authors.lastname: Wijns
mesh_terms: D000800:Angioplasty, Balloon; D001610:Beta Particles; D015415:Biomarkers / Q000097:blood; D001918:Brachytherapy; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000175:diagnosis / Q000235:genetics; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011879:Radiotherapy Dosage; D012307:Risk Factors; D015607:Stents; D018084:Ultrasonography, Interventional
chemical_list: D015415:Biomarkers; D007703:Peptidyl-Dipeptidase A