Is there any link between insulin resistance and inflammation in established preeclampsia?
Both insulin resistance and inflammation may contribute to the onset of preeclampsia. They also could be interrelated. We studied the relationship between inflammatory cytokines and markers of insulin resistance. During their third trimester, 22 proteinuric preeclamptic women and 16 normotensive controls underwent intravenous glucose tolerance test (minimal model). Preeclamptic women were more insulin-resistant (P = .009), and they had higher levels of serum soluble tumor necrosis alpha receptor II (TNFalpha RII) (P = .002), triglycerides (P = .006), uric acid (P = .001), and leptin (P = .002) than did the controls. However, the study groups did not differ in serum TNFalpha, C-reactive protein (CRP), interleukin-6 (IL-6), sex hormone-binding globulin (SHBG), and high-density lipoprotein-2 (HDL(2))-cholesterol. In multiple regression analysis only SHBG (P = .01) and triglycerides (P = .0036) were associated with insulin sensitivity independently of body mass index (BMI), weight gain, HDL(2)-cholesterol, CRP, TNFalpha, and TNFalpha RII, IL-6, and leptin. We conclude that insulin resistance and the inflammatory markers studied were not associated in established preeclampsia.
Kaaja
Risto
R
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
Laivuori
Hannele
H
Pulkki
Pekka
P
Tikkanen
Matti J
MJ
Hiilesmaa
Vilho
V
Ylikorkala
Olavi
O
D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D018836:Inflammation Mediators / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D012044:Regression Analysis; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
D015415:Biomarkers; D018836:Inflammation Mediators; D020738:Leptin; D018124:Receptors, Tumor Necrosis Factor; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D014527:Uric Acid