Glutamatergic system in bone physiology.
Bone is a highly innervated tissue consisting of nerve fibers, which contain many neurotransmitters including glutamate. Recently, a number of studies have identified functional glutamate receptors in osteoblasts and osteoclasts, implying that the glutamatergic system has an apparent regulatory role in bone physiology. This review outlines the evidence which suggest that the glutamatergic system regulates bone physiology.
Kalariti
Niki
N
Department of Experimental Physiology, Medical School, University of Athens, Goudi, Athens, Greece.
Koutsilieris
Michael
M
D000818:Animals; D001842:Bone and Bones / Q000294:innervation / Q000378:metabolism*; D002490:Central Nervous System / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism*
D017470:Receptors, Glutamate; D018698:Glutamic Acid