[A case of unresectable multiple liver metastases from colon cancer successfully treated by hepatic arterial infusion chemotherapy and systemic immunotherapy (IFNANK) followed by hepatic resection].
The patient was a 76-year-old man, diagnosed with sigmoid colon cancer with unresectable multible liver metastases. After sigmoidectomy with D2 regional lymphnode dissection on June 21, 2002 (moderately differentiated adenocarcinoma, ss, n(-), H3, P0, M(-), Stage IV), intermittent hepatic arterial infusion chemotherapy using 5-FU (1,250 mg/body/3 hr) and CDDP (10 mg/body/30 min) was performed weekly for 23 times, and then biweekly for 15 times. The total dosages of 5-FU were 47.5 g. During the regional chemotherapy, IFNANK therapy was performed biweekly as systemic immunotherapy. As a result, serum levels of tumor markers were remarkably decreased, and the metastatic liver tumors had disappeared in the CT finding in July 2003. Thereafter, IFNANK therapy was continued without the chemotherapy. However, CT and PET detected the recurrent liver tumors in December 2003, and the tumors were curatively resected on January 28, 2004.
Nakamura
Yoshitaka
Y
Dept of Digestive Surgery, Kyoto Prefectural University of Medicine.
Fujiwara
Hitoshi
H
Sonoyama
Teruhisa
T
Ochiai
Toshiya
T
Shimizu
Takeshi
T
Ichikawa
Daisuke
D
Okamoto
Kazuma
K
Sakakura
Chouhei
C
Ueda
Yuji
Y
Itoi
Hirosumi
H
Otsuji
Eigo
E
Hagiwara
Akeo
A
Yamagishi
Hisakazu
H
Mitsuishi
Yoko
Y
Kishida
Tsunataro
T
D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007261:Infusions, Intra-Arterial; D016898:Interferon-alpha / Q000494:pharmacology; D007937:Leukapheresis; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008197:Lymph Node Excision; D008297:Male
D016898:Interferon-alpha; D002945:Cisplatin; D005472:Fluorouracil