title: Enteric-coated layered double hydroxides as a controlled release drug delivery system.
abstract: Layered double hydroxides (LDHs) or so-called anionic clays consist of cationic brucite-like layers and exchangeable interlayer anions. Because of their biocompatibility, these layered inorganic solids can be used as host materials to create drug-LDH host-guest supramolecular structures. Because of the basicity of LDHs however, LDHs as drug delivery system will be limited for use in the stomach where pH is 1.2. A core-shell material has been prepared therefore in this work. A non-steroidal anti-inflammatory drug, Fenbufen-intercalated LDHs as the core was coated with enteric polymers, Eudragit S 100 or Eudragit L 100 as a shell, giving a composite material which shows controlled release of the drug under in vitro conditions which model the passage of a material through the gastrointestinal tract.
authors.affiliation: Ministry of Education Key Laboratory of Science and Technology of Controllable Chemical Reactions, Box 98, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Bingxin
authors.initials: B
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.forename: David G
authors.initials: DG
authors.lastname: Evans
authors.forename: Xue
authors.initials: X
authors.lastname: Duan
mesh_terms: D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000008:administration & dosage*; D010654:Phenylbutyrates / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility
chemical_list: D003692:Delayed-Action Preparations; D006878:Hydroxides; D010654:Phenylbutyrates; C010725:fenbufen