title: LTP and LTD vary with layer in rodent visual cortex.
abstract: Mechanisms of plasticity in the visual cortex have been studied with long-term potentiation (LTP), long-term depression (LTD) and ocular dominance plasticity (ODP). It is now possible to compare results from these three forms of plasticity using knockout mice, and also by pharmacological manipulations. A review of the literature shows that if both LTP and LTD are completely abolished, then ODP will also be abolished. In other situations, there is little correlation. We hypothesize that this lack of correlation occurs because the mechanisms for LTP and LTD vary with layer in the visual cortex, and results show that they do.
authors.affiliation: Department of Ophthalmology, Yale University Medical School, 330 Cedar Street, New Haven, CT 06520-8061, USA. nigel.daw@yale.edu
authors.forename: Nigel
authors.initials: N
authors.lastname: Daw
authors.forename: Yan
authors.initials: Y
authors.lastname: Rao
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Quentin
authors.initials: Q
authors.lastname: Fischer
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D023882:Dominance, Ocular / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D051381:Rats; D014793:Visual Cortex / Q000502:physiology*