title: Dual acting antihistaminergic agents.
abstract: Histamine is a primary mediator in allergic response and acts in concert with other agents to impact disease progression. Respiratory disorders such as asthma, rhinitis and dermatological conditions such as urticaria involve histamine along with other mediators. An antihistamine that possesses an additional property of counteracting the effects mediated by these other mediators should offer some therapeutic benefit over a selective antihistaminergic agent.
authors.affiliation: UCB Research Inc. 840 Memorial Drive, Cambridge, MA 02139, USA. ralph.scannell@ucb-group.com.
authors.forename: R T
authors.initials: RT
authors.lastname: Scannell
authors.forename: E
authors.initials: E
authors.lastname: Differding
authors.forename: P
authors.initials: P
authors.lastname: Talaga
mesh_terms: D000818:Animals; D065094:Bradykinin B2 Receptor Antagonists; D006634:Histamine H1 Antagonists / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D043782:Receptor, Bradykinin B2 / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism; D018039:Receptors, Tachykinin / Q000037:antagonists & inhibitors / Q000378:metabolism; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D065094:Bradykinin B2 Receptor Antagonists; D006634:Histamine H1 Antagonists; D015289:Leukotrienes; D043782:Receptor, Bradykinin B2; D011968:Receptors, Histamine; D018039:Receptors, Tachykinin; D044244:Receptors, Thromboxane A2, Prostaglandin H2