title: Modeling cerebral arteriovenous lactate kinetics after intravenous lactate infusion in the rat.
abstract: Venous-arterial lactate differences across the brain during lactate infusion in rats were studied, and the fate of lactate was described with a mathematical model that includes both cerebral and extracerebral kinetics. Ultrafiltration was used to sample continuously and simultaneously arterial and venous blood. Subsequent application of flow injection analysis and biosensors allowed the measurement of glucose and lactate concentrations every minute. Because of the high temporal resolution, arteriovenous lactate kinetics could be modeled in individual experiments. The existence of both a cerebral lactate sink and a lactate exchangeable compartment, representing approximately 24% of brain volume, was thus modeled.
authors.affiliation: Department of Psychiatry, Section Biological Psychiatry, University of Groningen, The Netherlands.
authors.forename: Gea
authors.initials: G
authors.lastname: Leegsma-Vogt
authors.forename: Siebren
authors.initials: S
authors.lastname: van der Werf
authors.forename: Kor
authors.initials: K
authors.lastname: Venema
authors.forename: Jakob
authors.initials: J
authors.lastname: Korf
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000502:physiology; D002550:Cerebral Veins / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D007275:Injections, Intravenous; D019344:Lactic Acid / Q000493:pharmacokinetics*; D008955:Models, Cardiovascular; D051381:Rats
chemical_list: D019344:Lactic Acid