title: [Evaluation of bronchial arterial infusion (BAI) for metastatic lung tumor from colorectal cancer].
abstract: Three cases of metastatic lung tumor from colorectal cancer with an ineffectual systemic chemotherapy were examined based on the therapeutic effectiveness and safety of bronchial infusion (BAI) as a symptomatic therapy. Two out of three cases were rectal cancer and the third case being ascending colon cancer. After the operations, each of the three cases showed a multiple lung metastases recurrence at the primary and metastatic lesions of the lung. The lung metastases became large in size and thoracic symptoms (severe cough, chest pain) appeared in spite of the systemic chemotherapy of CPT-11, 5-FU and CDDP. A low dosage of BAI was administered by using CPT-11 (40 mg/m2) + CDDP (40 mg/m2) as one shot, and was repeated (three and six times respectively) for the two cases. When the low dosage of BAI was administered, there were light side effects and no complications were observed. The average hospital stay was 7.8 days. All three patients were stable and showed improvement in the condition of the disease. The prognoses from the first BAI were 3, 6, and 9 months in all three cases, respectively. BAI using low dosage of anti-cancer agents was effective, as means of improving the chest condition and quality of life in patients with metastatic lung tumor from colorectal cancer, with an ineffectual systemic chemotherapy.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Otsuka Hospital.
authors.forename: Haruya
authors.initials: H
authors.lastname: Koshiishi
authors.forename: Tetunori
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamura
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Tamamoto
authors.forename: Eisuke
authors.initials: E
authors.lastname: Takahashi
authors.forename: Naganobu
authors.initials: N
authors.lastname: Hayashi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Koshiishi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001981:Bronchial Arteries; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002945:Cisplatin / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D000077146:Irinotecan; D007902:Length of Stay; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin