The role of nuclear Y-box binding protein 1 as a global marker in drug resistance.
Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non-P-glycoprotein.
Kuwano
Michihiko
M
Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka, Japan.
Oda
Yoshinao
Y
Izumi
Hiroto
H
Yang
Song-Ju
SJ
Uchiumi
Takeshi
T
Iwamoto
Yukihide
Y
Toi
Masakazu
M
Fujii
Teruhiko
T
Yamana
Hideaki
H
Kinoshita
Hisafumi
H
Kamura
Toshiharu
T
Tsuneyoshi
Masazumi
M
Yasumoto
Kosei
K
Kohno
Kimitoshi
K
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D021581:Active Transport, Cell Nucleus; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D006801:Humans; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000378:metabolism; D051840:Y-Box-Binding Protein 1
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human