Atonal points the way- protein-protein interactions and developmental biology.
Many cells maintain their state of determination long after the signals that induced it decay. In this issue of Developmental Cell, zur Lage and colleagues describe how certain cells sustain proneural gene expression through direct interactions between transcription factors.
Baker
Nicholas E
NE
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 1046, USA.
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins / Q000378:metabolism*; D004742:Enhancer Elements, Genetic; D066246:ErbB Receptors / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D009419:Nerve Tissue Proteins; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051880:Receptors, Notch; D012679:Sense Organs / Q000196:embryology; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D066246:ErbB Receptors; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011518:Proto-Oncogene Proteins; D051880:Receptors, Notch; D014157:Transcription Factors; C497759:N protein, Drosophila; C082142:ato protein, Drosophila; C083884:pnt protein, Drosophila