title: Ephrin-A5 overexpression degrades topographic specificity in the mouse gluteus maximus muscle.
abstract: Motor neurons project onto specific muscles with a distinct positional bias. We have previously shown using electrophysiological techniques that overexpression of ephrin-A5 degrades this topographic map. Here, we show that positional differences in axon terminal areas, an entirely different parameter of neuromuscular topography, are also eliminated with ephrin-A5 overexpression. Therefore, we now have both morphological and electrophysiological approaches to explore the mechanisms of neuromuscular topography.
authors.affiliation: Program in Neuroscience, Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lampa
authors.forename: S
authors.initials: S
authors.lastname: Potluri
authors.forename: A S
authors.initials: AS
authors.lastname: Norton
authors.forename: W
authors.initials: W
authors.lastname: Fusco
authors.forename: M B
authors.initials: MB
authors.lastname: Laskowski
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004594:Electrophysiology; D036386:Ephrin-A5 / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D005838:Genotype; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000294:innervation*; D017729:Presynaptic Terminals / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D036386:Ephrin-A5