title: [Amorphization in pharmaceutical technology].
abstract: The amorphization of crystalline active ingredients may be necessary because of the polymorphism of the active substance, the poor water-solubility of the drug material, difficult processing in the crystalline form and the taking out of a patent for a new (amorphous) form. This article introduces protocols for amorphization, which use methods traditionally applied in pharmaceutical technology. The protocols involve three possible routes: solvent methods, hot-melt technologies and milling procedures. With this presentation, the authors suggest help for practising experts to find the correct amorphization method.
authors.affiliation: Szegedi Tudományegyetem, Gyógyszertechnológiai Intézet, Szeged, Eötvös u. 6. - 6720.
authors.forename: Piroska
authors.initials: P
authors.lastname: Révész
authors.forename: Orsolya
authors.initials: O
authors.lastname: Laczkovich
authors.forename: István
authors.initials: I
authors.lastname: Eros
mesh_terms: D004355:Drug Stability; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations