Relationship of acute mania symptomatology to maintenance treatment response.
Most treatment of bipolar disorders addresses maintenance objectives. In the past 4 years, several large, blinded, randomized, placebo-controlled maintenance studies involving more than 3000 patients with bipolar I illness have been published, with analyses of background, symptomatic, and acute treatment factors contributing to maintenance effectiveness. This article summarizes these findings. Generally, indices of greater severity predict lower response rates to most monotherapy treatments. Some findings have been unexpected. Mixed mania did not predict different maintenance response to divalproex or lithium but predicted more side effects with either drug, and reduced efficacy of olanzapine or lamotrigine.
Bowden
Charles L
CL
The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive (Mail Code 7792), San Antonio, TX 78229, USA. bowdenc@uthscsa.edu
D000208:Acute Disease; D018692:Antimanic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology*; D006304:Health Status; D006801:Humans; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D018692:Antimanic Agents