[Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata].
OBJECTIVE
To investigate the effects of ultra-fine powder technique on dissolution rates of the components in Andrographis paniculata.


METHODS
High performance liquid chromatography was employed to determine the concentration of andrographolide and dehydroandrographolide in common powdered or ultra-fine powdered Andrographis paniculata.


RESULTS
The dissolution rates of andrographolide and dehydroandrographolide in ultra-fine powdered Andrographis paniculata were higher than those of the general powder.


CONCLUSIONS
Ultra-fine powder technique promotes the dissolution rates of andrographolide and dehydroandrographolide.
Qiu
Rong-Li
RL
Department of Medicinal Chemistry, School of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China. rongliq@hotmail.com
Li
Lin
L
Li
Xiang
X
Zhang
Hai-Xia
HX
Chen
Jian-Wei
JW
D035685:Andrographis / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000032:analysis*; D011208:Powders
D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D011208:Powders; C030419:andrographolide; C478098:dehydroandrographolide