title: A flexible approach toward trans-fused polycyclic tetrahydropyrans. A synthesis of prymnesin and yessotoxin units.
abstract: Ru-catalyzed cycloisomerization and oxidative cyclization of bis-homopropargylic alcohols provide a rapid iterative approach to structural units of the ladder toxins.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Rhee
mesh_terms: D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D008074:Lipoproteins / Q000138:chemical synthesis* / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D008978:Mollusk Venoms; D035964:Oxocins / Q000138:chemical synthesis* / Q000737:chemistry; D011714:Pyrans / Q000737:chemistry*
chemical_list: D004988:Ethers, Cyclic; D008074:Lipoproteins; D008387:Marine Toxins; D008978:Mollusk Venoms; D035964:Oxocins; D011714:Pyrans; C001884:prymnesin; C066632:yessotoxin