Intercellular adhesion molecule-1 expression in nasal polyps treated with corticosteroid.
OBJECTIVE
The aim of this study was to compare intracellular adhesion molecule-1 (ICAM-1) expression in nasal polyp cases who were administered topical corticosteroid and in middle turbinates.


METHODS
Twenty-four patients with nasal polyps were included in the study group. These patients were treated with 100 microg budesonide in each nostril twice daily for 2 months before the surgery. Twenty-one nonatopic patients with concha bullosa were included in the control group. The specimens were taken from patients undergoing endoscopic surgery.


RESULTS
In polyps, significantly higher mean ICAM-1 intensity scores were found by comparison with the control turbinates.


CONCLUSIONS
Corticosteroid treatment in patients with nasal polyps does not diminish ICAM-1 to that of turbinate tissue. The initiating events in the formation of nasal polyps still occur in these patients despite treatment with the topical nasal steroid.
Doner
Fehmi
F
Department of Otorhinolaryngology, Suleyman Demirel University School of Medicin,e, Isparta, Turkey. fehmidoner@hotmail.com
Sari
Ibrahim
I
Yariktas
Murat
M
Dogru
Harun
H
D000281:Administration, Intranasal; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use*; D016022:Case-Control Studies; D004727:Endothelium / Q000378:metabolism; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D008297:Male; D009298:Nasal Polyps / Q000188:drug therapy* / Q000378:metabolism; D014420:Turbinates / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D018799:Intercellular Adhesion Molecule-1; D019819:Budesonide