In vitro anti-tyrosinase activity of 5-(hydroxymethyl)-2-furfural isolated from Dictyophora indusiata.
The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5-(hydroxymethyl)-2-furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L-DOPA. On the basis of these findings some related analogues were also tested for their anti-tyrosinase activity, in order to gain more insight into structure and activity relationship among these heterocyclic compounds.
Sharma
Vinay K
VK
Applied Biotechnology Laboratory, Department of Biology, Kongju National University, Kongju, Republic of Korea.
Choi
Jinsuk
J
Sharma
Niti
N
Choi
Mieyoung
M
Seo
Sung-Yum
SY
D000363:Agaricales; D005662:Furaldehyde / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D014442:Monophenol Monooxygenase / Q000187:drug effects*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D013329:Structure-Activity Relationship
D010455:Peptides; C008046:5-hydroxymethylfurfural; D005662:Furaldehyde; D014442:Monophenol Monooxygenase