Evaluating the role of dexrazoxane as a cardioprotectant in cancer patients receiving anthracyclines.
Anthracyclines remain an important group of chemotherapeutic agents, despite their inherent cardiotoxicity. This cardiotoxicity may be even more of a concern in the future, as combination therapies of anthracyclines with newer agents become routine. Such combinations may be highly effective, but cardiotoxicity may also be increased. Dexrazoxane reduces the incidence of cardiotoxicity, as demonstrated in numerous clinical trials in both adults and children. Evidence from the literature suggests no effect of dexrazoxane on the antitumour efficacy of anthracyclines, and there is no adverse effect on survival. Dexrazoxane is therefore a valuable tool for oncologists using anthracycline-based regimens.
Pouillart
Pierre
P
Institut Curie, 26 Rue d'Ulm, 75005 Paris, France. pierre.pouillart@curie.net
D000328:Adult; D000818:Animals; D018943:Anthracyclines / Q000008:administration & dosage / Q000009:adverse effects*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D009202:Cardiomyopathies / Q000139:chemically induced / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D006333:Heart Failure / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D011929:Razoxane / Q000008:administration & dosage / Q000627:therapeutic use*
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents; D011929:Razoxane