Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation.
The present paradigm of atherogenesis proposes that low density lipoproteins (LDL) are trapped in subendothelial space of the vascular wall where they are oxidized. Myeloperoxidase (MPO) plays a key role in oxidative damage. We propose that LDL oxidation by myeloperoxidase (Mox-LDL) could occur at the surface of the endothelial cells and not restricted to the subendothelial space. The triad constituted by endothelial cells, circulating LDL and MPO in close interaction, constitutes a synergic mechanism for the genesis of Mox-LDL.
Zouaoui Boudjeltia
K
K
Laboratoire de Médecine Expérimentale (ULB 222 Unit) ISPPC Hôpital Vésale, Montigny-Le-Tilleul, Belgium. kaveroes@hotmail.com
Moguilevsky
N
N
Legssyer
I
I
Babar
S
S
Guillaume
M
M
Delree
P
P
Vanhaeverbeek
M
M
Brohee
D
D
Ducobu
J
J
Remacle
C
C
D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism*; D014471:Umbilical Veins / Q000166:cytology
D008077:Lipoproteins, LDL; D009195:Peroxidase