title: Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) hara.
abstract: Maoecrystal V (1), a novel C(19) diterpenoid possessing a unique 6,7-seco-6-nor-15(8-->9)-abeo-5,8-epoxy-ent-kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC(50) = 0.02 microg/mL (cis-platin: IC(50) = 0.99 microg/mL).
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Ma-Lin
authors.initials: ML
authors.lastname: Li
authors.forename: Qin-E
authors.initials: QE
authors.lastname: Tian
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.forename: Qi-Tai
authors.initials: QT
authors.lastname: Zheng
mesh_terms: D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular
chemical_list: D004224:Diterpenes