A bird's eye view on human B cells.
We show in this review that there is a continuum between the chicken B-cell system classified as the first GALT model described and the human B-cell system. We propose that humans have conserved for one B-cell subpopulation, the marginal zone B-cell subset in charge of T-independent responses, the strategies of diversification used by GALT species to generate their pre-immune repertoire.
Weill
Jean-Claude
JC
INSERM U373, Faculté de Médecine Necker-Enfants Malades, Université Paris V, 156 rue de Vaugirard, 75730 Paris Cedex 15, France. weill@necker.fr
Weller
Sandra
S
Reynaud
Claude-Agnès
CA
D000818:Animals; D000916:Antibody Diversity; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D005075:Biological Evolution; D002454:Cell Differentiation; D002645:Chickens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007422:Intestines / Q000276:immunology*; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology