Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer.
Several reports suggest that the glutathione-S-transferase (GST) family of enzymes is involved in a variety of cancers, due to their carcinogen-detoxification properties. A polymorphism in codon 105 of the pi variant (GSTP1 I105V), which affects the enzymatic activity of the enzyme, has been linked to the incidence of cancers from different organs. However, the published data in prostate cancer (PCa) is controversial. Some studies report an association with the GSTP1 I105V polymorphism and sporadic PCa, whereas other studies report no association. Recently, one study showed a positive correlation between the GSTP1 I105V polymorphism and familial PCa in a Japanese population. In the present study, we assessed the correlation of the GSTP1 I105V polymorphism with familial and sporadic PCa in an American population. We analyzed DNA samples from 438 patients with familial PCa, 499 patients with sporadic PCa, and 510 controls. We found no significant association between the GSTP1 I105V polymorphism and familial or sporadic PCa when compared to the control group [odds ratio (OR) =1.0 (0.74-1.37); P=0.58]. Moreover, no association was found after stratification for age of diagnosis, Gleason grade, or lymph node involvement [OR =0.84 (0.65-1.09), P=0.37]. These data indicate that there is no associated risk for sporadic or familial PCa in American families containing the GSTP1 I105V polymorphism.
Debes
Jose D
JD
Department of Urology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.
Yokomizo
Akira
A
McDonnell
Shannon K
SK
Hebbring
Scott J
SJ
Christensen
Gerald B
GB
Cunningham
Julie M
JM
Jacobsen
Steven J
SJ
Tindall
Donald J
DJ
Liu
Wanguo
W
Schaid
Daniel J
DJ
Thibodeau
Stephen N
SN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003062:Codon; D015331:Cohort Studies; D005192:Family Health; D005838:Genotype; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D007532:Isoleucine / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D014481:United States; D014633:Valine / Q000235:genetics*
D003062:Codon; D007527:Isoenzymes; D007532:Isoleucine; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D014633:Valine