title: Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography.
abstract: A distally actuated, rotational-scanning micromotor endoscope catheter probe is demonstrated for ultrahigh-resolution in vivo endoscopic optical coherence tomography (OCT) imaging. The probe permits focus adjustment for visualization of tissue morphology at varying depths with improved transverse resolution compared with standard OCT imaging probes. The distal actuation avoids nonuniform scanning motion artifacts that are present with other probe designs and can permit a wider range of imaging speeds. Ultrahigh-resolution endoscopic imaging is demonstrated in a rabbit with <4-microm axial resolution by use of a femtosecond Cr:forsterite laser light source. The micromotor endoscope catheter probe promises to improve OCT imaging performance in future endoscopic imaging applications.
authors.affiliation: Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Herz
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: A D
authors.initials: AD
authors.lastname: Aguirre
authors.forename: K
authors.initials: K
authors.lastname: Schneider
authors.forename: P
authors.initials: P
authors.lastname: Hsiung
authors.forename: J G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: K
authors.initials: K
authors.lastname: Madden
authors.forename: J
authors.initials: J
authors.lastname: Schmitt
authors.forename: J
authors.initials: J
authors.lastname: Goodnow
authors.forename: C
authors.initials: C
authors.lastname: Petersen
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D003106:Colon / Q000166:cytology*; D020685:Colonoscopes; D003113:Colonoscopy / Q000379:methods; D019723:Endoscopes; D004724:Endoscopy / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation*; D008904:Miniaturization / Q000379:methods; D009038:Motion; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods