Lack of toxic effects following acute overdose of cellcept (mycophenolate mofetil).
Mycophenolate mofetil is an immunosuppressive drug used for prevention of graft rejection following solid organ transplant and for treatment of autoimmune disorders. We report a case of a 24-year-old female with lupus nephritis that presented following ingestion of 10 grams of mycophenolate in a suicide gesture. Serum levels confirmed ingestion. The patient was treated with decontamination and supportive care and recovered with no adverse effect.
Bebarta
Vikhyat S
VS
Rocky Mountain Poison and Drug Center-Denver Health, Division of Emergency Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
Heard
Kennon
K
Nadelson
Craig
C
D000328:Adult; D000931:Antidotes / Q000627:therapeutic use; D001772:Blood Cell Count; D002606:Charcoal / Q000627:therapeutic use; D062787:Drug Overdose; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007166:Immunosuppressive Agents / Q000506:poisoning* / Q000627:therapeutic use; D008181:Lupus Nephritis / Q000188:drug therapy; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000506:poisoning* / Q000627:therapeutic use; D013406:Suicide, Attempted
D000931:Antidotes; D007166:Immunosuppressive Agents; D002606:Charcoal; D009173:Mycophenolic Acid