How do ABC transporters drive transport?
Members of the ATP-binding cassette (ABC) superfamily are integral membrane proteins that hydrolyze ATP to drive transport. In the last two decades these proteins have been extensively characterized on a genetic and biochemical level, and in recent years high-resolution crystal structures of several nucleotide-binding domains and full-length transporters have extended our knowledge. Here we discuss the possible mechanisms of transport that have been derived from these crystal structures and the extensive available biochemical data.
van der Does
Chris
C
Institute of Biochemistry, Biozentrum Frankfurt, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439 Frankfurt/Main, Germany.
Tampé
Robert
R
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D001692:Biological Transport / Q000502:physiology; D006801:Humans; D017433:Protein Structure, Secondary / Q000502:physiology
D018528:ATP-Binding Cassette Transporters