title: Antibodies to Chlamydia trachomatis heat shock proteins Hsp60 and Hsp10 and subfertility in general population at age 31.
abstract: OBJECTIVE
  To assess the association between antibodies to Chlamydia trachomatis heat shock proteins 60 and 10 (Hsp60 and Hsp10) and subfertility in a general population sample.
  
  
  METHODS
  A nested case (n = 146)-control (n = 278) study in a population-based birth cohort. Serum immunoglobulin (Ig)G and IgA antibodies against C. trachomatis Hsp60 and Hsp10, explanatory factors, were measured by enzyme immunoassay, using recombinant proteins as antigens. The main outcome variable was subfertility (time to pregnancy > or =12 months).
  
  
  RESULTS
  The prevalence and medians of serum IgA antibodies to Hsp60 and Hsp10 were significantly higher in the female partners of subfertile couple than in their fertile controls. On the contrary, among male partners of subfertile couple, especially among smokers serum antibody levels to Hsp antigens were lower than in the controls.
  
  
  CONCLUSIONS
  The results indicate a serological association of antibodies to chlamydial Hsp antigens with female subfertility in a population-based sample.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Oulu, Finland. liisa.karinen@oulu.fi
authors.forename: L
authors.initials: L
authors.lastname: Karinen
authors.forename: A
authors.initials: A
authors.lastname: Pouta
authors.forename: A-L
authors.initials: AL
authors.lastname: Hartikainen
authors.forename: A
authors.initials: A
authors.lastname: Bloigu
authors.forename: M
authors.initials: M
authors.lastname: Paldanius
authors.forename: M
authors.initials: M
authors.lastname: Leinonen
authors.forename: P
authors.initials: P
authors.lastname: Saikku
authors.forename: M-R
authors.initials: MR
authors.lastname: Järvelin
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D016022:Case-Control Studies; D018835:Chaperonin 10 / Q000276:immunology*; D018834:Chaperonin 60 / Q000276:immunology*; D002690:Chlamydia Infections / Q000150:complications* / Q000453:epidemiology; D002692:Chlamydia trachomatis / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D007248:Infertility, Male / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D008297:Male
chemical_list: D000907:Antibodies, Bacterial; D018835:Chaperonin 10; D018834:Chaperonin 60