The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis.
The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an increased initial granulocytic infiltration because of overproduction of the CXC chemokines, MIP-2 and keratinocyte-derived cytokine. This differential response is dependent upon particle internalization and can be mimicked by advanced glycation end product-BSA-conjugated latex beads. Thus SR-A is a nonactivating receptor, which is the first example of a pattern recognition receptor that serves to counter the activities of proinflammatory receptors and attenuates the production of specific chemokines to ensure an inflammatory response of the appropriate magnitude.
Cotena
Alessia
A
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
Gordon
Siamon
S
Platt
Nick
N
D000199:Actins / Q000378:metabolism / Q000502:physiology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D002478:Cells, Cultured; D054360:Chemokine CXCL1; D054426:Chemokine CXCL2; D018925:Chemokines / Q000096:biosynthesis; D019743:Chemokines, CXC / Q000096:biosynthesis*; D016207:Cytokines / Q000096:biosynthesis; D017127:Glycation End Products, Advanced / Q000494:pharmacology; D007375:Interleukin-1 / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D018345:Mice, Knockout; D008863:Microspheres; D009504:Neutrophils / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D010537:Peritoneum / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D010538:Peritonitis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D011971:Receptors, Immunologic / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013864:Thioglycolates / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000199:Actins; D000276:Adjuvants, Immunologic; D054360:Chemokine CXCL1; D054426:Chemokine CXCL2; D018925:Chemokines; D019743:Chemokines, CXC; C475895:Cxcl1 protein, mouse; C404915:Cxcl2 protein, mouse; D016207:Cytokines; D017127:Glycation End Products, Advanced; D007375:Interleukin-1; D008070:Lipopolysaccharides; C495140:Msr1 protein, mouse; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D013864:Thioglycolates; D014409:Tumor Necrosis Factor-alpha; C081628:advanced glycation end products-bovine serum albumin; C074302:keratinocyte-derived chemokines; D012710:Serum Albumin, Bovine