[Comparison of gastrointestinal toxicity in patients with advanced cervical carcinoma treated with concomitant chemotherapy and radiotherapy versus radiotherapy alone].
BACKGROUND
Cervical carcinoma is the second most often malignant tumor of female in Bosnia and Hercegovina. About 70% of patients in the time of diagnosis have advanced disease, when prognosis and results of treatment are poor. Improvement of survival and local control of disease could be possible with combined chemo-radiotherapy treatment, expecting higher gastrointestinal toxicity.


OBJECTIVE
Comparation of gastrointestinal toxicity in patients with advanced cervical carcinoma treated with concomitant chemo-radiotherapy versus radiotherapy alone.


METHODS
From 1997-1999, we performed prospective, randomised study, and 80 patients were divided in two groups: Group A--40 patients treated with concomitant chemo-radiotherapy versus, Group B--40 patients treated with radiotherapy alone. Gastrointestinal toxicity was evaluated before enrollement, during the therapy, immediately after the treatment, 3 and 6 months, according to the CTC toxicity criteria.


RESULTS
We performed statistical analysis using H2 test, and we found no significant differencies in mild and severe gastrointestinal toxicity among groups, while in the Grade 1 toxicity we found statistical differencies in nausea and vomitus, and no differencies in diarrhoa.
Kantaradzić
Nermina
N
Nermina Kantardzić, Semir Beslija, Mirela Kalamujić Institut za onkologiju, Klinicki centar Univerziteta u Sarajevu.
Beslija
Selim
S
Kalamujić
Mirela
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D003967:Diarrhea / Q000139:chemically induced / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D014839:Vomiting / Q000139:chemically induced / Q000209:etiology*