Food intake in rhesus monkeys following central administration of orexins.
Orexin A has been reported to stimulate food intake in rats while orexin B does not. The purpose of this study was to determine the role of orexin A or orexin B administration on food intake in adult, male rhesus monkeys. Food intake was measured at 2 and 8 h after the morning feeding following central injections of vehicle, orexin A (10, or 20 microg) or orexin B (10, 30, or 100 microg). When compared to vehicle injections, the 10 and 20 microg doses of orexin A decreased food intake at 2 h post-dose by 45% and 64%, respectively. Eight-hour food intake was decreased at only the 20 microg orexin A dose. Orexin B at all doses and time points did not alter food intake when compared to vehicle. These results indicate that orexin A exhibits anorectic activity while orexin B does not affect food intake in the rhesus monkey.
Ramsey
Jon J
JJ
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. jjramsey@ucdavis.edu
Kemnitz
Joseph W
JW
Newton
Wendy
W
Hagopian
Kevork
K
Patterson
Terrell A
TA
Swick
Andrew G
AG
D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D007276:Injections, Intraventricular; D047908:Intracellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000494:pharmacology*; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D009479:Neuropeptides / Q000008:administration & dosage* / Q000494:pharmacology*; D000068797:Orexins
D001067:Appetite Depressants; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins