Risk factors for anti tuberculous drugs induced hepatitis: a prospective survey from a chest clinic in a general hospital.
A prospective survey on 14 consecutive cases with tuberculous drug induced hepatitis was done at our chest clinic in a state general hospital over a period of 15 months. There were 30 controls chosen randomly from the chest clinic register. The cases had lower mean body mass index (P<0.008), serum albumin (P<0.005) and higher serum globulin (P<0.04). Serum liver transaminases and total bilirubin rose significantly during the acute episode of drug induced hepatitis. Among the risk factors studied, only chronic hepatitis B carrier status was found to be more prevalent among the cases. There was one death (7.1%) over the whole study period.
Fauzi
A R M
AR
Department of Internal Medicine, Kulliyah of Medicine, Kuantan, Pahang, Malaysia.
Shah
A
A
Rathor
M Y
MY
Satwi
S
S
D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D016009:Chi-Square Distribution; D005260:Female; D006769:Hospitals, General; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors
D000995:Antitubercular Agents