title: Synthesis of alpha-fluorosulfonamides by electrophilic fluorination.
abstract: Alpha-fluorosulfonamides were prepared by electrophilic fluorination of tertiary sulfonamides using N-fluorobenzenesulfonimide as fluorinating agent and utilizing the dimethoxybenzyl group (DMB) as a new sulfonamide protecting group. Removal of the DMB group with TFA/CH(2)Cl(2) gave primary and secondary alpha-fluorosulfonamides.
authors.affiliation: Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Bryan
authors.initials: B
authors.lastname: Hill
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Scott D
authors.initials: SD
authors.lastname: Taylor