Familial occurrence of bovine dilated cardiomyopathy in Denmark.
Bovine dilated cardiomyopathy (BDCM) is a hereditary disease genetically related to the Canadian Holstein sire Montwick Red Apple Sovereign (MRAS). The occurrence of this disorder in the Red Danish Dairy breed, Holsteins, and Red Holsteins in Denmark is reported. Fourteen cases were diagnosed during a 13-year period. All suffered from congestive heart failure because of progressive myocardial fibrosis. Pedigree information was available in 12 cases revealing both maternal and paternal relationship to MRAS. Several sires were identified as carriers of BDCM. These sires originated from breeding lines used to upgrade Danish cattle populations. The findings indicate that BDCM is a potential health problem for Danish cattle.
Leifsson
P S
PS
Department of Veterinary Pathobiology, Bülowsvej 17, 1870 Frederiksberg C, Denmark. ple@kvl.dk
Agerholm
J S
JS
D000818:Animals; D001947:Breeding; D002311:Cardiomyopathy, Dilated / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D003718:Denmark / Q000453:epidemiology; D017809:Fatal Outcome; D005260:Female; D005820:Genetic Testing; D008297:Male; D010375:Pedigree