Profiles of ortho-polychlorinated biphenyl congeners, dichlorodiphenyldichloroethylene, hexachlorobenzene, and Mirex among male Lake Ontario sportfish consumers: the New York State Angler cohort study.
Great Lakes sportfish consumption is a recognized human exposure source to environmental organochlorine compounds. Using data collected as part of the New York State Angler Cohort Study, 203 males were considered with regard to history of Lake Ontario sportfish consumption and sera levels of 57 ortho-substituted polychlorinated biphenyl (PCB) congeners, dichlorodiphenyldichloroethylene, hexachlorobenzene, and Mirex. Consumption of six species of highly contaminated Lake Ontario sportfish during the years 1980 to 1990 was considered. Exposure was weighted by average annual frequency of consumption, whole-fish PCB estimates, and meal size to determine a continuous index of exposure. This index was dichotomized to compare "consumers" to "nonconsumers" in several procedures. Recovery and lipid-adjusted serum values for PCB congener IUPAC Nos. 138+163 (rsp=0.3), 183 (rsp=0.3), 187 (rsp=0.4), and 188 (rsp=0.3) and Mirex (rsp=0.4) were significantly correlated with the index of fish consumption (P<0.001). A logistic regression model, using forward stepwise selection procedures (alpha in/out=0.002/0.004), was employed to account for high intercorrelations among organochlorine predictor variables. Mirex was the sole statistically significant predictor variable of "consumer/nonconsumer." A one-unit increase in log Mirex was associated with a 92.0% increase in the odds of having reported sportfish consumption (OR=1.92, 95%CI=1.43, 2.58). Age, body mass index, cigarette smoking, water/wildfowl consumption, and year of sampling were considered covariates. The results of this study support the premise that long-term dietary consumption of Lake Ontario sportfish, even at comparatively low levels, contributes significantly to the body burden of organochlorine compounds in western New York anglers and sportsmen.
Bloom
Michael S
MS
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, 3435 Main St. Buffalo, NY 14214-3000, USA. msbloom@buffalo.edu
Vena
John E
JE
Swanson
Mya K
MK
Moysich
Kirsten B
KB
Olson
James R
JR
D000818:Animals; D015331:Cohort Studies; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D005399:Fishes; D005506:Food Contamination; D006114:Great Lakes Region; D006581:Hexachlorobenzene / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D008297:Male; D008917:Mirex / Q000097:blood; D009518:New York / Q000453:epidemiology; D011078:Polychlorinated Biphenyls / Q000097:blood; D013177:Sports; D011795:Surveys and Questionnaires
D006843:Hydrocarbons, Chlorinated; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D011078:Polychlorinated Biphenyls; D008917:Mirex