A simple, general and efficient ketone synthesis via alkylation and dephosphinoylation of beta-keto-diphenylphosphine oxides.
Products of difficult ketone alkylation reactions can be made selectively via activation with a diphenylphosphinoyl group; subsequent dephosphinoylation is easily achieved in base.
Fox
David J
DJ
University Chemical Laboratory, Cambridge, UK.
Pedersen
Daniel Sejer
DS
Warren
Stuart
S