Differential diagnosis of chronic dysimmune demyelinating polyneuropathies with and without anti-MAG antibodies.
The distinction between chronic demyelinating polyneuropathies associated with IgM paraproteinemia and anti-myelin-associated glycoprotein (MAG) antibodies (MAG-PN) and chronic inflammatory demyelinating polyneuropathies (CIDPs) relies on the anti-MAG antibodies assay. The aim of the study was to identify clinical and electrophysiological features suggesting a diagnosis of MAG-PN. Fourteen patients with MAG-PN and 35 with CIDP were included, and a discriminant analysis was performed to identify the clinical and electrophysiological features suggestive of MAG-PN. Pure sensory clinical phenotype, low median and ulnar terminal latency index, and absence of M responses in the lower limbs were significantly associated with the diagnosis of MAG-PN, and indicate a moderate to large increase in probability of this diagnosis in patients with chronic dysimmune demyelinating polyneuropathies.
Isoardo
G
G
Divisione di Neurologia, Ospedale Civile, Via Botallo 4, 14100 Asti, Italy. gianlucaisoardo@yahoo.it <gianlucaisoardo@yahoo.it>
Migliaretti
G
G
Ciaramitaro
P
P
Rota
E
E
Poglio
F
F
Tavella
A
A
Paolasso
I
I
Cavallo
F
F
Bergamasco
B
B
Cocito
D
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D048909:Diabetes Complications; D003937:Diagnosis, Differential; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D011237:Predictive Value of Tests; D011446:Prospective Studies
D001323:Autoantibodies; D015415:Biomarkers; D018992:Myelin-Associated Glycoprotein