Clinicopathological and biological characteristics of esophageal squamous cell carcinoma associated with head and neck cancer.
OBJECTIVE
Esophageal cancer has been reported to be frequently associated with cancer of the head and neck. The iodine dye method is reportedly useful to detect early esophageal cancer. The aim of this study was to clarify clinicopathological and biological characteristics of esophageal squamous cell carcinoma associated with head and neck cancer (HN group).


METHODS
Thirty-seven patients of the HN group who underwent esophagectomy were examined clinicopathologically compared to 42 patients with esophageal cancer alone (SE group). All resected specimens were histologically studied after iodine dye staining, and p53 and cyclin D1 (CD1) expression were immunohistochemically examined in esophageal cancer.


RESULTS
The HN group had more multiple iodine-unstained lesions and multiple primary cancers within the esophagus compared with the SE group (p = 0.0027, p = 0.067, respectively). There was no significant difference in smoking, drinking, family history and the other clinicopathological factors between the HN and SE groups. Coexpression of p53 and CD1 was found to be significant in the HN group (p = 0.03).


CONCLUSIONS
The coexistence of multiple iodine-unstained lesions, multiple cancers in the esophagus and overexpression of p53 and CD1 is suggested as a risk factor for the HN group.
Matsumoto
Masataka
M
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. masa2@m2.kufm.kagoshima-u.ac.jp
Natsugoe
Shoji
S
Okumura
Hiroshi
H
Ishigami
Sumiya
S
Takatori
Hiroyuki
H
Nakashima
Hiroshi
H
Takao
Sonshin
S
Aikou
Takashi
T
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D019938:Cyclin D1 / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1