title: Augustamine type alkaloids from Crinum kirkii.
abstract: Sixteen more Amaryllidaceae alkaloids have been isolated from bulbs of Crinum kirkii Baker of which noraugustamine and 4a,N-dedihydronoraugustamine are hitherto unknown. Their structures and those of earlier known alkaloids have been established by physical and spectroscopic analysis. Application of 2D NMR techniques was used for complete characterization of the alkaloids as well as of 3-O-acetylsanguinine. 1,2-Diacetyllycorine and 3-O-acetylsanguinine showed activity against Trypanosoma brucci rhodesiense, the parasite associated with sleeping sickness. 3-O-acetylsanguinine also showed some activity against Trypanosoma cruzi.
authors.affiliation: Department of Chemistry, Kenyatta University, PO Box 43844, 00100 GPO, Nairobi, Kenya.
authors.forename: Alex K
authors.initials: AK
authors.lastname: Machocho
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastida
authors.forename: Carlos
authors.initials: C
authors.lastname: Codina
authors.forename: Francesc
authors.initials: F
authors.lastname: Viladomat
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Sumesh C
authors.initials: SC
authors.lastname: Chhabra
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology; D031407:Crinum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D013053:Spectrophotometry
chemical_list: D000470:Alkaloids; D000981:Antiprotozoal Agents