Creutzfeldt-Jakob disease presenting as refractory nonconvulsive status epilepticus.
A 70-year-old woman was admitted to the intensive care unit with refractory nonconvulsive status epilepticus. Extensive evaluation including neuroimaging and cerebrospinal fluid examination was unrevealing. Brain biopsy revealed spongiosis, and prion disease was confirmed by immunostaining, providing the diagnosis of Creutzfeldt-Jakob disease.
Shapiro
Janet M
JM
Department of Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY, USA. Jshapiro@chpnet.org
Shujaat
Adil
A
Wang
Jill
J
Chen
Xiaowei
X
D000368:Aged; D001037:Aphasia / Q000209:etiology; D001706:Biopsy; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control; D003422:Critical Care / Q000379:methods; D003937:Diagnosis, Differential; D018450:Disease Progression; D004569:Electroencephalography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007118:Immunoassay; D017053:Infection Control / Q000379:methods; D010291:Paresis / Q000209:etiology; D016133:Polymerase Chain Reaction; D035583:Rare Diseases; D013226:Status Epilepticus / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*