title: Effects of uvalino, a new autochthonous wine, on the inhibition of the production of hydroxyl radicals.
abstract: In view of the high concentration of resveratrol found in a new autochthonous wine (Uvalino) and the notable antioxidant activity of this substance, we decided to assess whether this wine could inhibit the production of free radicals. Nowadays, free radicals are considered to be the most noxious factors for tissues, triggering the development of many diseases. The assessments were carried out using a direct and more precise technique, electronic paramagnetic resonance (EPR), which is able to detect the ability of an antioxidant agent to inhibit the formation of hydroxyl radicals (*OH), which are among the most noxious reactive oxygen species (ROS). The results show that Uvalino wine is able to eliminate ROS production almost completely. Consequently, it has beneficial effects on health in all the diseases in which ROS plays an important pathogenetic role.
authors.affiliation: Department of Pharmacology, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bertelli
authors.forename: R
authors.initials: R
authors.lastname: Morelli
authors.forename: M
authors.initials: M
authors.lastname: Falchi
mesh_terms: D000975:Antioxidants / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D003497:Cyclic N-Oxides / Q000737:chemistry / Q000378:metabolism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D007501:Iron / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008519:Medicine, Traditional; D000077185:Resveratrol; D019097:Spin Trapping / Q000379:methods; D013267:Stilbenes / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D014920:Wine / Q000032:analysis*
chemical_list: D000975:Antioxidants; D003497:Cyclic N-Oxides; C045076:Fenton's reagent; D013267:Stilbenes; D017665:Hydroxyl Radical; C017245:5,5-dimethyl-1-pyrroline-1-oxide; D006861:Hydrogen Peroxide; D007501:Iron; D000077185:Resveratrol