title: Leptin acts peripherally to limit meal-induced increases in plasma insulin concentrations in mice: a brief communication.
abstract: Leptin inhibits food intake and lowers plasma insulin concentrations. This study was designed to determine whether leptin acts independent of food-intake regulation to affect meal-induced increases in plasma insulin concentrations. Leptin-deficient, Lep(ob)/Lep(ob) mice were administered 1 microg leptin intracerebroventricularly (ICV) or intraperitoneally. Food intake and plasma insulin concentrations of mice administered leptin ICV before a meal were lower, as expected, than were intakes and plasma insulin concentrations of mice administered vehicle ICV. However when food intake was controlled, meal-induced increases in plasma insulin were unaffected by ICV administration of leptin. Intraperitoneal administration of 1 microg leptin before a meal lowered meal-induced increases in plasma insulin concentrations without influencing the size of the meal. We conclude that plasma leptin concentrations can affect meal-induced insulin secretion independent of the central nervous system actions of leptin associated with food-intake regulation.
authors.affiliation: Department of Nutrition, Food, and Exercise Science, Florida State University, Tallahassee, FL 32306-1493, USA. amistry@garnet.acns.fsu.edu.
authors.forename: Anahita M
authors.initials: AM
authors.lastname: Mistry
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Swick
authors.forename: Dale R
authors.initials: DR
authors.lastname: Romsos
mesh_terms: D000818:Animals; D004435:Eating; D005260:Female; D005508:Food Deprivation; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000008:administration & dosage* / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D051379:Mice; D008820:Mice, Obese; D013997:Time Factors
chemical_list: D007328:Insulin; D020738:Leptin