Pulmonary capillaritis with hemorrhage due to propylthiouracil therapy in a child.
We report on a case of pulmonary capillaritis with diffuse alveolar hemorrhage in a child due to propylthiouracil (PTU). PTU treatment is a rare cause of pulmonary capillaritis in adults; we report on the first case in a pediatric patient. The treatment of pulmonary capillaritis often requires corticosteroid therapy, other immunosuppressive medications, or withdrawal of the causative agent. Our patient recovered completely after treatment with a limited course of corticosteroids and removal of PTU.
Pirot
Anayansi Lasso
AL
Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134, USA.
Goldsmith
Donald
D
Pascasio
Judy
J
Beck
Suzanne E
SE
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002196:Capillaries / Q000473:pathology*; D002648:Child; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007249:Inflammation; D008168:Lung / Q000098:blood supply*; D008171:Lung Diseases / Q000139:chemically induced* / Q000188:drug therapy; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D013956:Antithyroid Agents; D011441:Propylthiouracil