[Age-related metabolic development in rats: insulin's role].
The aim of our work was to study the developmental changes in plasma and hepatic concentrations of carbohydrates, lipids, and proteins in "Wistar" rats between prepartum day 1 (fetus considered J-1) and postpartum day 133 (adult considered j+133). In addition, the evolution of insulinemia has been examined. The 21 day aged fetus (j-1), as compared to the adult (j+133) showed a lower glycemia, a higher stock of hepatic glycogen, lower rates of lipids and proteins in the plasma and in the liver. The fetal insulinemia was significantly higher than adult's. After the delivrance we have attended to an increase of the glycemia and a very marked depletion of the glycogenic stock in the liver. The plasma and hepatic lipids and proteins rose after birth. The insulinemia fell considerably and reached the lowest level. Between the 14th and 30th day of the postnatal life, a restoration of the stock of the hepatic glycogen, a normal glycemia, an elevation of the plasma and hepatic rates of proteins, and a decrease of the lipidic levels in plasma and liver were recorded. In addition the concentration of insulin increased during this period. All these values remained steady during the adult stage. We conclude that the development of rats is accompanied with several metabolic and hormonal changes. These are particularly marked at birth and weaning.
Mornagui
Bessem
B
Laboratoire de Physiologie Animale, Département de Biologie, Faculté des Sciences de Tunis, Tunisie.
Grissa
Abir
A
El
Fazaa Saloua
FS
Gharib
Claude
C
Kamoun
Abdelaziz
A
Gharbi
Najoua
N
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D047109:Fetal Development; D007328:Insulin / Q000502:physiology*; D051381:Rats
D007328:Insulin