title: Non-small-cell lung cancer: multimodality approach in stage-III resectable disease.
abstract: The long-term results of surgery +/- radiotherapy in patients with operable disease of locally advanced non-small-cell lung cancer are discouraging. In the vast majority, disseminated microscopic disease, resulting in the later occurrence of distant metastases, contributes substantially to this poor long-term outcome. The further development of multimodality treatment approaches in randomised trials, including effective systemic therapy, is necessary. These approaches and the current status of multimodality treatment strategies of resectable locally advanced non-small-cell lung cancer are discussed.
authors.affiliation: Department of Hematology, Medical Oncology and Respiratory Medicine, University of Münster, Albert-Schweitzer Str. 33, D-48129 Münster, Germany. mthomas@uni-muenster.de
authors.forename: Michael
authors.initials: M
authors.lastname: Thomas
authors.forename: Petra
authors.initials: P
authors.lastname: Hoffknecht
authors.forename: Cornelia
authors.initials: C
authors.lastname: Droege
authors.forename: Andreas
authors.initials: A
authors.lastname: Baisch
authors.forename: Niels
authors.initials: N
authors.lastname: Reinmuth
authors.forename: Michael
authors.initials: M
authors.lastname: Kreuter
authors.forename: Tobias
authors.initials: T
authors.lastname: Lange
authors.forename: Wolfgang E
authors.initials: WE
authors.lastname: Berdel
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D009367:Neoplasm Staging