Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia.
Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.
Miyazaki
Ikuko
I
Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikatacho, Okayama 700-8558, Japan.
Asanuma
Masato
M
Diaz-Corrales
Francisco J
FJ
Miyoshi
Ko
K
Ogawa
Norio
N
D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001479:Basal Ganglia / Q000166:cytology* / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D017362:Cyclic AMP Response Element-Binding Protein; D012333:RNA, Messenger; D011954:Receptors, Dopamine