The role of pathogenic B-cell clones in antibody mediated autoimmune disorders.
Our understanding of the role of B-cells in the immunopathogenesis of certain antibody mediated diseases has developed remarkably in the past few years. In this review, autoantibody mediated immune disorders associated with pathogenic B-cell clones are discussed. We have focused on the roles and pathogenic mechanisms of B-cell clones in autoantibodyimmune diseases. The roles of pathogenic B-cells in Castleman's disease in PNP patients is used as one example. The developments in the treatment of B-cell mediated autoimmune diseases, such as intravenous immunoglobulin (IVIg), targets the regulatory pathway of B-cells, using anti-CD20, CD19, CD22 and, CD95 monoclonal antibody therapy, etc. are also discussed. Immunotherapy, targeting specific pathogenic B-cells, is believed to be one approach in the management of autoimmune diseases.
Wang
Jing
J
Department of Dermatology, Peking University First Hospital, Beijing 100034, China.
Zhu
Xuejun
X
D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology*; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology*; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D006801:Humans
D001323:Autoantibodies