Association of inhibin B serum levels with parameters of follicular response in a randomized controlled trial comparing gnRH agonist versus antagonist protocols for ovarian hyperstimulation.
OBJECTIVE
To study the association of inhibin B with ovarian response to FSH stimulation, applying either GnRH agonist or antagonist.


METHODS
In a prospective randomized controlled trial, 46 patients undergoing COH received either triptorelin (group I, n = 15) or ganirelix (group II, n = 31). Parameters of follicular response and inhibin B serum levels were assessed.


RESULTS
Inhibin B before FSH stimulation was significantly lower in group I than group II. The FSH stimulation phase was significantly longer in group I than group II, and the total FSH dose was significantly higher with a comparable number of retrieved oocytes. Day 1 inhibin B in group I, but not group II, was significantly correlated with the number of large ovarian follicles and retrieved oocytes. In group II, but not group I, inhibin B on day 1 was inversely correlated with the daily and total FSH dose as well as FSH stimulation duration.


CONCLUSIONS
The association of inhibin B serum levels with parameters of follicular response in COH is different in patients assigned to GnRH agonist vs. antagonist treatment protocols.
Sonntag
Barbara
B
Department of Obstetrics and Gynecology of the University, Albert-Schweitzer-Str. 33, 48149 Münster, Germany.
Kiesel
Ludwig
L
Nieschlag
Eberhard
E
Behre
Hermann M
HM
D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000627:therapeutic use*; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007265:Inhibins / Q000097:blood*; D008186:Luteolytic Agents / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D006727:Hormone Antagonists; D008186:Luteolytic Agents; C422364:inhibin B; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins; C061018:ganirelix