title: Facile synthesis of @-tide beta-strand peptidomimetics: improved assembly in solution and on solid phase.
abstract: The synthesis of @-tide beta-strand peptidomimetics has been improved such that oligomers now can be obtained from solution- and solid-phase synthesis protocols approaching the efficiency and flexibility of peptide chemistry. These methods enable the synthesis of @-tide oligomers with a variety of amino acids and with lengths up to 13 units. [reaction: see text]
authors.affiliation: Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.
authors.forename: Scott T
authors.initials: ST
authors.lastname: Phillips
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piersanti
authors.forename: Matthias
authors.initials: M
authors.lastname: Rüth
authors.forename: Niko
authors.initials: N
authors.lastname: Gubernator
authors.forename: Bettina
authors.initials: B
authors.lastname: van Lengerich
authors.forename: Paul A
authors.initials: PA
authors.lastname: Bartlett
mesh_terms: D020650:Combinatorial Chemistry Techniques; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis*
chemical_list: D009842:Oligopeptides