[Genotoxicity evaluation of paracetamol applying Allium test].
Paracetamol genotoxic potential was evaluated among different concentrations, applying Allium test on Allium cepa. Total number of roots, number of dark roots, the length of the longest root, the average root, and the shortest root were determined. Statistically significant differences among total number of roots (p > 0.05) was observed at concentrations of 50 microg/ml and 100 microg/ml, and highly statistically significant differences at concentrations of 5 microg/ml and 25 microg/ml, while at the highest concentration (400 microg/ml) was observed statistically significant higher number of roots in comparation to all other concentrations of paracetamol and control group. The results of research suggest the concentrations of 5 microg/ml, 25 microg/ml and 400 microg/ml for further evaluation of paracetamol mutagenic potential.
Aganović-Musinović
Izeta
I
Centar za humanu gentiku, Medicinski fakultet Univerziteta u Sarajevu.
Todić
Maida
M
Becić
Fahir
F
Kusturica
Jasna
J
D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D009152:Mutagenicity Tests; D019697:Onions / Q000187:drug effects*; D018517:Plant Roots / Q000187:drug effects
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen