title: How does neonatal thymectomy affect the immune system?
abstract: BACKGROUND
  The aim of this study was to determine the effects of neonatal thymectomy on the immune system in later life.
  
  
  RESULTS
  Immune system tests were performed in 26 children at 1 year of age. Thirteen of them had been operated for transposition of the great arteries and had thymectomy in the same operation in the neonatal period. Thirteen control subjects were normal. Immune system tests including white blood cell count, lymphocyte count, T and B cells subgroups (CD2, CD4, CD5, CD7, CD8, CD16, CD20, CD22, CD56), mitotic reaction to phytohaemagglutinin in lymphocyte culture. White blood cell count and lymphocyte count were performed. In the statistical analysis, Mann-Whitney U and Wilcoxon rank sum W tests were used for both groups. Statistical significance was taken at a value of P < 0.05. There was no significant difference in mean white blood cell count, mean blastic transformation reaction of lymphocytes to phytohaemagglutinin, and CD7, CD4/CD8, CD20, CD22, CD56 ratios between the two groups (P > 0.05). Significant differences in mean lymphocyte number, and CD2, CD4, CD5, CD8, CD16 ratios between the two groups were defined (P < 0.05).
  
  
  CONCLUSIONS
  In our study, it was noticed that mainly T lymphocyte subgroups were effected by neonatal thymectomy. Although no infection requiring therapy was seen in the thymectomized patients, we advise to limit total thymectomy as much as possible in neonatal heart operations.
authors.affiliation: Department of Cardiovascular Surgery, Cardiology Institute of Istanbul University, Cerrahpasa Medical Faculty of Istanbul University, Istanbul, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Turan
authors.forename: Arzu
authors.initials: A
authors.lastname: Turan
authors.forename: Caner
authors.initials: C
authors.lastname: Arslan
authors.forename: Barbaros
authors.initials: B
authors.lastname: Kinoglu
authors.forename: Tayyar
authors.initials: T
authors.lastname: Sarioglu
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007159:Immunologic Tests; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D018655:Lymphocyte Count; D013934:Thymectomy / Q000009:adverse effects*; D014188:Transposition of Great Vessels / Q000601:surgery