Proteolysis: Adaptor, adaptor, catch me a catch.
The ClpXP protease of bacteria can degrade a wide variety of proteins while maintaining remarkable substrate selectivity. New work in Escherichia coli implicates adaptor proteins in enhancing substrate selectivity and regulating the flow of substrates to cellular proteases.
Ades
Sarah E
SE
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
D002352:Carrier Proteins / Q000378:metabolism*; D049071:Endopeptidase Clp / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D013379:Substrate Specificity
D002352:Carrier Proteins; D029968:Escherichia coli Proteins; C477700:sspB protein, E coli; C483573:ClpXP protease, E coli; D049071:Endopeptidase Clp