Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception.
This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocaine (2%; 0.1, 0.3 or 1.0 microl) or muscimol (0.34 nmol; 0.5 microl) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals.
Göktalay
Gökhan
G
Department of Basic and Pharmaceutical Sciences, Albany College of Pharmacy, Union University, 106 New Scotland Avenue, Albany, NY 12208, USA.
Levendusky
Mark C
MC
Millington
William R
WR
D000818:Animals; D001919:Bradycardia / Q000209:etiology / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D018755:GABA Agonists / Q000008:administration & dosage*; D006710:Homocysteine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009118:Muscimol / Q000008:administration & dosage*; D010146:Pain / Q000150:complications / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D018755:GABA Agonists; D006710:Homocysteine; C007956:homocysteic acid; D009118:Muscimol