Chiral recognition by mass-resolved laser spectroscopy.
Chiral recognition is a fundamental phenomenon in life sciences, based on the enantioselective complexation of a chiral molecule with a chiral selector. The diastereomeric aggregates, formed by complexation, are held together by a different combination of intermolecular forces and are therefore endowed with different stability and reactivity. Determination of these forces, which are normally affected in the condensed phase by solvent and supramolecular interactions, requires the generation of the diastereomeric complexes in the isolated state and their spectroscopic investigation. This review deals with chiral recognition in the gas phase through the application of laser-resolved mass spectrometric techniques (R2PI-TOF and RET-MS). The measurement of the fragmentation thresholds of diastereomeric clusters by these techniques allows the determination of the nature of the intrinsic interactions, which control their formation and affect their stability and reactivity.
Speranza
Maurizio
M
Facoltà di Farmacia, Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università di Roma La Sapienza, pl. A. Moro 5, I-00185 Roma, Italy. maurizio.speranza@uniroma1.it
Satta
Mauro
M
Piccirillo
Susanna
S
Rondino
Flaminia
F
Paladini
Alessandra
A
Giardini
Anna
A
Filippi
Antonello
A
Catone
Daniele
D
D004735:Energy Transfer; D004867:Equipment Design; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D007477:Ions / Q000032:analysis* / Q000737:chemistry*; D007536:Isomerism; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation* / Q000379:methods* / Q000639:trends
D007477:Ions