title: Non-specific effects of vaccination on child survival: prospective cohort study in Burkina Faso.
abstract: OBJECTIVE
  To study the effect of vaccination on mortality before 2 years of age in a developing country.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Rural communities in Burkina Faso.
  
  
  METHODS
  9085 children born in the study area between 1985 and 1993.
  
  
  METHODS
  Child death rate.
  
  
  RESULTS
  Mortality before 2 years of age was lower in children who had been vaccinated: those vaccinated with BCG only had significantly lower mortality (risk ratio for vaccinated v unvaccinated children 0.37, 95% confidence interval 0.29 to 0.48) as did those vaccinated with diphtheria, tetanus, and pertussis only (0.24, 0.13 to 0.43). The second dose of diphtheria, tetanus, and pertussis was not associated with lower mortality (0.80, 0.58 to 1.12).
  
  
  CONCLUSIONS
  Vaccination with diphtheria, tetanus, and pertussis as well as BCG is associated with better survival of children up to 2 years of age.
authors.affiliation: Institut de Recherche pour le Développement, Laboratoire Population, Environnement et Développement, BP 64501, 34394 Montpellier Cedex 5, France. vaugelad@ird.fr
authors.forename: J
authors.initials: J
authors.lastname: Vaugelade
authors.forename: S
authors.initials: S
authors.lastname: Pinchinat
authors.forename: G
authors.initials: G
authors.lastname: Guiella
authors.forename: E
authors.initials: E
authors.lastname: Elguero
authors.forename: F
authors.initials: F
authors.lastname: Simondon
mesh_terms: D001500:BCG Vaccine; D002050:Burkina Faso / Q000453:epidemiology; D015331:Cohort Studies; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D005260:Female; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D012423:Rural Health; D015996:Survival Rate; D014611:Vaccination / Q000401:mortality*
chemical_list: D001500:BCG Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine