title: Carboplatinum and vincristine chemotherapy for central nervous system gliofibroma: case report and review of the literature.
abstract: Gliofibromas are bimorphic tumors of the central nervous system. Although they are composed of astrocytic and fibroblastic elements, their histogenesis is not clear. An attempt has been made to classify the tumors as low- or high-grade based on morphology and proliferative labeling index, but the clinical behavior and the optimal therapeutic strategies remain unknown. Although they are considered benign, the authors' review shows a 23% mortality rate. The authors report the successful use of carboplatinum and vincristine as treatment of this disease.
authors.affiliation: Department of Pediatrics, Section of Hematology Oncology, University of Louisville School of Medicine, Louisville, Kentucky, USA. csuarez@psm.edu
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Suarez
authors.forename: Ashok B
authors.initials: AB
authors.lastname: Raj
authors.forename: Salvatore J
authors.initials: SJ
authors.lastname: Bertolone
authors.forename: Susan
authors.initials: S
authors.lastname: Coventry
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D016190:Carboplatin / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009457:Neuroglia / Q000473:pathology; D012074:Remission Induction; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D014750:Vincristine; D016190:Carboplatin