Impairment of sensorimotor gating in mice deficient in the cell adhesion molecule L1 or its close homologue, CHL1.
Mutations in the gene encoding the cell adhesion molecule L1 or its close homologue, CHL1 (close homologue of L1), cause brain dysfunction in both humans and mice. Here we report that prepulse inhibition (PPI) of the acoustic startle response is impaired in mice deficient in either L1 or CHL1. This newly identified feature may provide a basis for using these mice as models for sensorimotor gating impairment found in some neuropsychiatric disorders such as schizophrenia.
Irintchev
Andrey
A
Zentrum für Molekulare Neurobiologie, Universität Hamburg, D-20246 Hamburg, Germany.
Koch
Michael
M
Needham
Leila K
LK
Maness
Patricia
P
Schachner
Melitta
M
D000161:Acoustic Stimulation; D000818:Animals; D015815:Cell Adhesion Molecules; D005260:Female; D015640:Ion Channel Gating / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D023421:Models, Animal; D039842:Neural Cell Adhesion Molecule L1 / Q000172:deficiency / Q000502:physiology*; D009433:Neural Inhibition / Q000235:genetics / Q000502:physiology*; D011506:Proteins / Q000502:physiology; D013216:Reflex, Startle / Q000235:genetics / Q000502:physiology*
D015815:Cell Adhesion Molecules; C490649:Chl1 protein, mouse; D039842:Neural Cell Adhesion Molecule L1; D011506:Proteins