[Safety research of a vaccine preparation in hepatitis A derived from the MB-7 rapidly growing strain].
A study was undertaken to prove that a vaccine drug based on the fast-growing MB-7 (MB-7 VD) of hepatitis A virus (HAV) is safe. It was established that MB-7 VD, when once injected to white outbred mice and when 4 times injected to Hartley guineas pigs, did not cause any hematological and biochemical changes in the peripheral blood or in the condition of the central nervous system of experimental animals, which shows that MB-7 VD is free of any toxic properties.
Smerdova
M A
MA
Usova
S V
SV
Isaeva
A F
AF
Kutina
S N
SN
Netesov
S V
SV
Maĭdaniuk
A G
AG
Muntianova
M A
MA
Nemtsov
Iu V
IuV
Kriuk
N I
NI
Iashin
V V
VV
Karpovich
L G
LG
Kalashnikova
T V
TV
D000818:Animals; D001772:Blood Cell Count; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D006454:Hemoglobins / Q000032:analysis; D006506:Hepatitis A / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D022362:Hepatitis A Vaccines / Q000008:administration & dosage* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D014611:Vaccination
D006454:Hemoglobins; D022362:Hepatitis A Vaccines