Solid-phase synthesis of N-bi- and N-terarylpiperazines via three different and consecutive palladium-catalyzed cross-coupling reactions.
Novel nonsymmetrical N-bi- and N-terarylpiperazines were synthesized on solid phase via three consecutive palladium-catalyzed cross-coupling reactions in which C-N, C-B, and C-C bonds are formed consecutively.
Ruhland
Thomas
T
Department of Medicinal Chemistry, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. tr@lundbeck.com
Svejgaard
Lars
L
Rasmussen
Lars Kyhn
LK
Andersen
Kim
K