title: [Host immunity in colorectal cancer patients treated with low-dose Leucovorin plus 5-fluorouracil].
abstract: In colorectal cancer, low-dose Leucovorin plus 5-FU therapy does not induce any severe adverse effects, and patients could receive this therapy for many cycles. The aim of this study was to investigate the relationship between host immunity and this regimen. Seven patients were enrolled in this study. Host immunity was investigated before and after chemotherapy. The ratio of Th1/Th2, PHA response, serum IAP level and the productions of IL-6, IL-10 and soluble IL-2 receptor did not change significantly before and after chemotherapy. Since low-dose Leucovorin plus 5-FU therapy might not influence host immunity, patients could receive the therapy for a long duration without toxicity.
authors.affiliation: Dept. of Surgery, Tokyo Women's Medical University Daini Hospital.
authors.forename: Rie
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yoshimatsu
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Hajime
authors.initials: H
authors.lastname: Yokomizo
authors.forename: Arihiro
authors.initials: A
authors.lastname: Umehara
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Yoshida
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Kiyo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Kenji
authors.initials: K
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D002955:Leucovorin / Q000008:administration & dosage; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D015375:Receptors, Interleukin-2 / Q000097:blood; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D013997:Time Factors
chemical_list: D016209:Interleukin-8; D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2; D016753:Interleukin-10; D002955:Leucovorin; D005472:Fluorouracil