Emergent FDA biodefense issues for microarray technology: process analytical technology.
A successful biodefense strategy relies upon any combination of four approaches. A nation can protect its troops and citizenry first by advanced mass vaccination, second, by responsive ring vaccination, and third, by post-exposure therapeutic treatment (including vaccine therapies). Finally, protection can be achieved by rapid detection followed by exposure limitation (suites and air filters) or immediate treatment (e.g., antibiotics, rapid vaccines and iodine pills). All of these strategies rely upon or are enhanced by microarray technologies. Microarrays can be used to screen, engineer and test vaccines. They are also used to construct early detection tools. While effective biodefense utilizes a variety of tactical tools, microarray technology is a valuable arrow in that quiver.
Weinberg
Sandy
S
GE Healthcare, Fast Trak - Vaccines, USA. sandy.weinberg@ge.com
D023482:Bioterrorism; D002959:Civil Defense / Q000379:methods; D005104:Expert Testimony; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000592:standards*; D014481:United States; D014486:United States Food and Drug Administration