Is there a place for inhibition of cervical ripening in the management of preterm labour?
Although premature cervical ripening is one of the two major pathophysiological processes occurring in preterm labour, research has mostly focused on the development of tocolytic agents. Our goal in this study was to review the recent progress made in the understanding of cervical ripening physiology and to explore the molecules that could be targeted for the development of new pharmacological compounds capable of inhibiting this process and to further improve the management of preterm labour.
Schmitz
Thomas
T
Maternité Port-Royal Hopital Cochin, AP-HP, Université René Descartes, Paris, France. thomas.schmitz@med.nyu.edu
D000818:Animals; D023802:Cerclage, Cervical / Q000379:methods; D020070:Cervical Ripening / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D018570:Risk Assessment; D015149:Tocolytic Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
D015149:Tocolytic Agents