title: A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes.
abstract: Copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of nonfluorescent 3-azidocoumarins and terminal alkynes afforded intense fluorescent 1,2,3-triazole products. The mild condition of this reaction allowed us to construct a large library of pure fluorescent coumarin dyes. Since both azide and alkyne are quite inert to biological systems, this reaction has potential in bioconjugation and bioimaging applications. [reaction: see text]
authors.affiliation: Department of Chemistry & Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA.
authors.forename: Krishnamoorthy
authors.initials: K
authors.lastname: Sivakumar
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.forename: Brandon M
authors.initials: BM
authors.lastname: Cash
authors.forename: Su
authors.initials: S
authors.lastname: Long
authors.forename: Hannah N
authors.initials: HN
authors.lastname: Barnhill
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang