title: Donor-recipient gender mismatch in lung transplantation: impact on obliterative bronchiolitis and survival.
abstract: BACKGROUND
  Because of the shortage of donor lungs, liberalization of donor selection criteria in terms of age, gas exchange, and smoking history has been proposed.
  
  
  METHODS
  We evaluated a single-institution population of lung transplant recipients (n = 98) for donor-recipient gender matching. We measured overall survival, time to acute allograft rejection, and time to development of obliterative bronchiolitis (OB).
  
  
  RESULTS
  We found significant improvement in overall survival for gender-mismatched donor and recipient pairs (p = 0.078) and a significantly shorter OB-free period for male donor and female recipient pairs (p = 0.017).
  
  
  CONCLUSIONS
  These findings suggest that donor organ allocation based on gender may affect long-term survival and other outcomes after lung transplantation.
authors.affiliation: Pulmonary and Critical Care Unit, General Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Roberts
authors.forename: John C
authors.initials: JC
authors.lastname: Wain
authors.forename: Yuchiao
authors.initials: Y
authors.lastname: Chang
authors.forename: Leo C
authors.initials: LC
authors.lastname: Ginns
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001989:Bronchiolitis Obliterans / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D014019:Tissue Donors