title: Pediatric hepatic angiosarcoma: case report and review of the literature.
abstract: Pediatric hepatic angiosarcoma (PHAS) is a rare tumor, which usually presents as a rapid enlargement of the liver. To date, surgery, chemotherapy, and radiotherapy have not improved the poor prognosis of PHAS with only three survivors reported. The histology of PHAS is distinct from adult angiosarcoma, because PHAS displays hypercellular whorls of sarcomatous cells, or "kaposiform" spindle cells, in addition to the general features of angiosarcoma. We report a case of PHAS that was treated with vascular ablation, chemotherapy, and liver transplantation. Lung metastases occurred 14 months posttransplant.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.
authors.forename: Haytham H
authors.initials: HH
authors.lastname: Dimashkieh
authors.forename: Jun Q
authors.initials: JQ
authors.lastname: Mo
authors.forename: Josephine
authors.initials: J
authors.lastname: Wyatt-Ashmead
authors.forename: Margaret H
authors.initials: MH
authors.lastname: Collins
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004621:Embolization, Therapeutic; D005260:Female; D006394:Hemangiosarcoma / Q000556:secondary* / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy*; D016031:Liver Transplantation; D008175:Lung Neoplasms / Q000556:secondary; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents