Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients.
We studied the role of cytochrome P4501A1 (CYP1A1 Val/Val) genotypes in the etiology of acute lymphoblastic leukemia (ALL) in adult Mexican patients. Distributions of CYP1A1 Val/Val genotypes in peripheral blood DNA samples from 136 healthy controls and 136 adult patients with ALL were evaluated. There was an increased frequency of the CYP1A1 Val/Val genotype among ALL patients, showing a significant association between this genotype and the risk of developing ALL.
Gallegos-Arreola
M P
MP
División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Guadalajara, Jalisco, México. marthaga@foreigner.class.udg.mx
Batista-González
C M
CM
Delgado-Lamas
J L
JL
Figuera
L E
LE
Puebla-Pérez
A M
AM
Arnaud-López
L
L
Peralta-Leal
V
V
Ramírez-Jirano
L J
LJ
Zúñiga-González
G M
GM
D000293:Adolescent; D000328:Adult; D000368:Aged; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
D019363:Cytochrome P-450 CYP1A1