title: HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia.
abstract: OBJECTIVE
  The purpose of our study was to evaluate the significance of polymorphisms in HLA class II genes in coronary artery ectasia (CAE) patients.
  
  
  RESULTS
  Twenty-six patients with CAE without associated cardiac defects were enrolled in the study. CAE was defined as luminal dilation of 1.5- to 2.0-fold of normal limits. Ninety-five healthy subjects who were donors for different organ transplantations, were chosen as control group. Physical examination, electrocardiography and chest X-ray were completely normal in these cases. Both the patients and the control group were screened and compared for their HLA class II genotypes. HLA-DR B1*13, DR16, DQ2 and DQ5 genotypes were significantly more frequent in the patient group. When the known risk factors of coronary heart disease were compared in the patients carrying these genotypes with the non-carrying group, no significant differences were encountered.
  
  
  CONCLUSIONS
  HLA-DR B1*13, DR16, DQ2 and DQ5 may be associated with the pathogenesis and increase the risk of CAE.
authors.affiliation: Abant Izzet Baysal University Düzce Faculty of Medicine Dept of Cardiology Konuralp Düzce, Turkey. rakdemir@yahoo.com
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozhan
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Gunduz
authors.forename: Enver
authors.initials: E
authors.lastname: Erbilen
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yazici
authors.forename: Sadik
authors.initials: S
authors.lastname: Duran
authors.forename: Funda
authors.initials: F
authors.lastname: Orkunoglu
authors.forename: Sinan
authors.initials: S
authors.lastname: Albayrak
authors.forename: Necat
authors.initials: N
authors.lastname: Imirzalioglu
authors.forename: Cihangir
authors.initials: C
authors.lastname: Uyan
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D003331:Coronary Vessels / Q000473:pathology*; D004108:Dilatation, Pathologic / Q000235:genetics; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains