title: Cocaine downregulates the expression of the mitochondrial genome in rat brain.
abstract: Analysis by differential display of genes induced in response to acute cocaine administration to rats revealed the significant downregulation of several mitochondrial genes in the cingulate cortex, including the subunits 1, 2, 4, 5, and 6 of NADH dehydrogenase and the subunit 2 of cytochrome c oxidase. Although the mechanism of the downregulation of expression of these mitochondrial genes by cocaine is presently not well understood, one can envisage that it involves an increased production of reactive oxygen species in cells of the cerebral cortex.
authors.affiliation: INSERM U 575, Centre de Neurochimie, 67084 Strasbourg, France. jbdietrich@neurochem.u-strasbg.fr
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Dietrich
authors.forename: Raphaël
authors.initials: R
authors.lastname: Poirier
authors.forename: Dominique
authors.initials: D
authors.lastname: Aunis
authors.forename: Jean
authors.initials: J
authors.lastname: Zwiller
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000235:genetics*; D003042:Cocaine / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects* / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects*; D016678:Genome; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003042:Cocaine