title: Transition metal salt-catalyzed direct three-component mannich reactions of aldehydes, ketones, and carbamates: efficient synthesis of N-protected beta-aryl-beta-amino ketone compounds.
abstract: The transition metal salt-catalyzed direct three-component Mannich reactions of aryl aldehydes, aryl ketones, and carbamates are described. The RuCl(3).xH(2)O-, AuCl(3)-PPh(3)-, and AuCl(3)-catalyzed direct Mannich reactions led to the synthesis of N-protected beta-aryl-beta-amino ketones, and the results create new possibilities for exploiting the transition metal salt-catalyzed direct Mannich reaction and facile synthesis of beta-amino ketone libraries.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PRC.
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Xu
authors.forename: Chun-Gu
authors.initials: CG
authors.lastname: Xia
authors.forename: Lyi
authors.initials: L
authors.lastname: Li