title: Direct effects of high concentrations of dimethylsulfoniopropionate, vitamin E and ferulic acid on the senility of aged scenescene-accelerated mouse (SAMP8).
abstract: The effects of high concentrations of dimethylsulfoniopropionate (DMSP), vitamin E and ferulic acid solutions on the aging of male and female scenescene-accelerated mouse (SAMP8) at the age of 50 wk were examined by direct supplementation to their stomachs twice a week for 28-30 d. The addition of 1 mL of DMSP, vitamin E and ferulic acid solutions (21% each) to the male and female mice in each group in this order rather elevated their growth and significantly suppressed their total grading score and loss of learning and memory with increasing rearing times for the short experimental period. However, there were no significant differences found between the male and female mice during the experimental period. The antioxidant and hormonal actions for the effects of the test compounds on the aged SAMP8 were possibly considered.
authors.affiliation: Laboratory of Biochemistry, Faculty of Nutrition, Koshien University, Hyogo, Japan. nakajima@koshien.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakajima
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003373:Coumaric Acids / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D012737:Sex Factors; D013452:Sulfonium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D013452:Sulfonium Compounds; D014810:Vitamin E; C004999:ferulic acid; C068078:dimethylpropiothetin