Overexpression of Her2/neu is observed in one third of adult acute lymphoblastic leukemia patients and is associated with chemoresistance in these patients.
Among 100 patients with acute lymphoblastic leukemia (ALL), 15 B-ALL patients were found positive for surface Her2/neu expression. The incidence in children was only 3.4% compared to 31% in adults (p=0.001). Considering only adult B-ALL patients (n=38), surface Her2/neu expression was associated with chemoresistance (50% versus 11%, p=0.03) suggesting that it could be a prognostic marker of poor clinical outcome in ALL.
Chevallier
Patrice
P
Robillard
Nelly
N
Wuilleme-Toumi
Soraya
S
Méchinaud
Françoise
F
Harousseau
Jean-Luc
JL
Avet-Loiseau
Hervé
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D018734:Genes, erbB-2; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000503:physiopathology*