title: [Continuous regional arterial infusion of protease inhibitor and antibiotic for severe acute pancreatitis].
abstract: Continuous regional arterial infusion (CRAI) of protease inhibitor and antibiotic has been established as an initial treatment for severe acute pancreatitis in Japan. CRAI therapy reduced the mortality rate and the frequency of infected pancreatic necrosis. Recently vasospasm has been recognized to be involved in the development of pancreatic ischemia or hypoperfusion in the early phase of the disease, and early application of CRAI of nafamostat may protect the evolution of ischemia into necrosis by inhibition of the increase in the intravascular coagulant activity.
authors.affiliation: Department of Gastroenterological Surgery, Tohoku University, Graduate School of Medicine.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Takeda
mesh_terms: D000208:Acute Disease; D000792:Angiography; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001550:Benzamidines; D002986:Clinical Trials as Topic; D006146:Guanidines / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D010179:Pancreas / Q000098:blood supply; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D019283:Pancreatitis, Acute Necrotizing / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control; D011480:Protease Inhibitors / Q000008:administration & dosage*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001550:Benzamidines; D006146:Guanidines; D011480:Protease Inhibitors; C032855:nafamostat