title: Site-selective DNA photocleavage involving unusual photoinitiated tautomerization of chiral tridentate vanadyl(V) complexes derived from N-salicylidene alpha-amino acids.
abstract: The titled vanadyl(V) complexes serve as efficient reagents for cleaving supercoiled plasmid DNA by photoinitiation. Complex 3d, derived from 2-hydroxy-1-naphthaldehyde and l-phenylalanine, exhibits a unique wedge feature, inducing a site-selective photocleavage at the C22-T23 of the bulge backbone for a HIV-27 DNA system at 0.1-5 muM. Transient absorption experiments for 3d indicate the involvement of LMCT with concomitant tautomerization, leading to an o-quinone-methide V-bound hydroxyl species responsible for the cleavage profiles. [structure: see text]
authors.affiliation: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan. chefv43@scc.ntnu.edu.tw
authors.forename: Chien-Tien
authors.initials: CT
authors.lastname: Chen
authors.forename: Jin-Sheng
authors.initials: JS
authors.lastname: Lin
authors.forename: Jen-Huang
authors.initials: JH
authors.lastname: Kuo
authors.forename: Shiue-Shien
authors.initials: SS
authors.lastname: Weng
authors.forename: Ting-Shen
authors.initials: TS
authors.lastname: Cuo
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Lin
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Cheng
authors.forename: Yan-Chen
authors.initials: YC
authors.lastname: Huang
authors.forename: Jen-Kan
authors.initials: JK
authors.lastname: Yu
authors.forename: Pi-Tai
authors.initials: PT
authors.lastname: Chou
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D016325:HIV Long Terminal Repeat; D008958:Models, Molecular; D010782:Photolysis; D010957:Plasmids / Q000737:chemistry; D017968:Vanadium Compounds / Q000737:chemistry*
chemical_list: D017968:Vanadium Compounds; D004247:DNA