title: [A case of postoperative pelvic metastasis and multiple liver metastases of the rectal cancer successfully treated by arterial infusion therapy with 5-FU/leucovorin].
abstract: A 55-year-old man underwent a rectal amputation for rectal cancer in 1994. As the tumor marker was elevated in 2002, we performed an abdominal CT scan and detected local and multiple liver recurrences. We treated the patient with intra-arterial infusion of 5-FU/LV via the internal iliac artery and the hepatic artery. The chemotherapy was performed on a weekly basis; it consisted of 5-FU (500 mg/body), administered for 5 hours to bilateral reservoirs through an infusion pump and l-leucovorin (400 mg/body), administered intravenously for 2 hours. After 18 administrations of this regimen during a hospital stay and after a discharge from the hospital as an outpatient, the multiple liver metastases that were observed have disappeared. Further, the local recurrences showed a partial reduction in tumor size with a decrease in perineal pain. Subsequently, the patient did not require further doses of morphine. He exhibited no severe side effects except for grade 1 nausea, and his QOL was also good. Therefore, local intra-arterial infusion chemotherapy with 5-FU/LV appears to have been effective for rectal cancer recurrences.
authors.affiliation: Dept. of Surgery, Division of Digestive Surgery, Kyoto Prefectural University of Medicine.
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakashima
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Araki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Shojiro
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ochiai
authors.forename: Chohei
authors.initials: C
authors.lastname: Sakakura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ueda
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Sonoyama
authors.forename: Akeo
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Yamagishi
authors.forename: Seishiro
authors.initials: S
authors.lastname: Inaba
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007083:Iliac Artery; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010386:Pelvic Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D011183:Postoperative Complications; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D002955:Leucovorin; D005472:Fluorouracil