title: Effect of an essential oil mouthrinse, with and without fluoride, on plaque metabolic acid production and pH after a sucrose challenge.
abstract: This clinical study evaluated the effect of rinsing with an essential oil-containing antiseptic mouthrinse, with or without 100 mg/kg fluoride ion, on the plaque metabolic acid production and plaque pH response after a sucrose challenge. This observer-blind, randomized study used a three-way crossover design. Twenty-four subjects rinsed with 20 ml of one of the following rinses: (1) essential oil (EO) mouthrinse, (2) essential oil mouthrinse plus 100 mg/kg fluoride, or (3) negative control, for 30 s, twice daily for 16 days. On day 17, 1 h after the last mouthrinse, subjects rinsed with 20 ml of mass fraction 10% sucrose solution for 1 min. Seven minutes after the sucrose challenge, supragingival plaque was collected from molar and premolar teeth. Plaque pH and metabolic acid ions were analyzed using a micro pH electrode and capillary electrophoresis, respectively. The results showed that after EO mouthrinse dental plaque produced 36% less lactate, 36% less acetate and 44% less propionate than after the negative control rinse. The dental plaque also exhibited a pH 0.42 unit higher after EO rinse than after the negative control rinse. These results were not affected by the addition of 100 mg/kg fluoride to the EO mouthrinse. From these results we concluded that this EO antiseptic mouthrinse, with or without fluoride ion, is effective in reduction of plaque acidogenicity after a sucrose challenge.
authors.affiliation: Pfizer Inc., Morris Plains, NJ 07950, USA. Jane.Zhang@pfizer.com
authors.forename: J Z
authors.initials: JZ
authors.lastname: Zhang
authors.forename: D S
authors.initials: DS
authors.lastname: Harper
authors.forename: G L
authors.initials: GL
authors.lastname: Vogel
authors.forename: G
authors.initials: G
authors.lastname: Schumacher
mesh_terms: D019342:Acetic Acid / Q000378:metabolism; D000328:Adult; D000704:Analysis of Variance; D018441:Biofilms / Q000187:drug effects; D002327:Cariostatic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000188:drug therapy / Q000378:metabolism*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D019344:Lactic Acid / Q000096:biosynthesis; D008297:Male; D009067:Mouthwashes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011422:Propionates / Q000378:metabolism; D012459:Salicylates / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D016037:Single-Blind Method; D012969:Sodium Fluoride / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013395:Sucrose / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D002327:Cariostatic Agents; D004338:Drug Combinations; D009067:Mouthwashes; D011422:Propionates; D012459:Salicylates; D013729:Terpenes; D019344:Lactic Acid; C057473:Listerine; D013395:Sucrose; D012969:Sodium Fluoride; C029658:propionic acid; D019342:Acetic Acid