p53 autoantibodies predict subsequent development of cancer.
Because TP53 mutations can induce an immune response and can occur early in the carcinogenic process for some tumors, p53 autoantibodies may be useful biomarkers for risk of development of cancer. Using banked serum samples from an asbestosis cohort at high risk for cancer, we demonstrate for the first time a statistically significant relationship between p53 autoantibodies and the subsequent development of malignancy (hazard ratio [HR] = 5.5, 95% confidence interval [CI] = 2.8-10.9) with a positive predictive value of 0.76 and an average lead time to diagnosis of 3.5 years. p53 autoantibodies were also significantly associated with p53 alterations in the resultant tumors (kappa = 0.78, p = 0.01).
Li
Yongliang
Y
Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA.
Karjalainen
Antti
A
Koskinen
Heikki
H
Hemminki
Kari
K
Vainio
Harri
H
Shnaidman
Michael
M
Ying
Zhiliang
Z
Pukkala
Eero
E
Brandt-Rauf
Paul W
PW
D001195:Asbestosis / Q000150:complications* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000276:immunology*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D018570:Risk Assessment; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
D001323:Autoantibodies; D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53