[Case report on intra-tumor injection therapy of dendritic cells in advanced gastric cancer].
Dendritic cells (DC) are powerful antigen-presenting cells, and have attracted attention in recent years from the viewpoint of DC vaccine therapy against cancer. However, the existence of an immunosuppressive state in cancer individuals leads to anergy and failure in cytotoxic T cell (CTL) induction and DC migration to the target organ. It has been reported that injected intra-tumor DCs are expected to work phagocytosis of the tumor as a localized effect. Consequently CTL induction in the tumor and the regional lymphnodes results in a systemic effect. In this study, intra-tumor DC injection therapy was performed by means of endoscopic ultrasonography (EUS) in 2 gastric cancer cases. As a result, tumor markers and ascites of one case were on the decrease. The results indicate this method can be useful in advanced cancer patients.
Kanazawa
Masashi
M
Dept of Surgery II, Fukushima Medical University.
Yoshihara
Kazue
K
Abe
Hiroyuki
H
Iwadate
Manabu
M
Watanabe
Kumiko
K
Suzuki
Satoshi
S
Endoh
Yoshiyuki
Y
Ohki
Shinnji
S
Takita
Ken-ichi
K
Sekikawa
Kouji
K
Takenoshita
Seiichi
S
Takagi
Tadayuki
T
Irisawa
Atsushi
A
Sato
Yukio
Y
Ogata
Takashi
T
Ohto
Hitoshi
H
D003713:Dendritic Cells / Q000637:transplantation*; D019160:Endosonography; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D015552:Injections, Intralesional; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000628:therapy*