Synthesis of a new class of furan-fused tetracyclic compounds using o-quinodimethane chemistry and investigation of their antiviral Activity.
The synthesis and evaluation of antiviral activity of new furan-fused tetracyclic compounds are described. The syntheses were satisfactorily achieved on the basis of o-quinodimethane chemistry, using furan-containing benzocyclobutene derivatives as a substrate, in high generality and stereoselectivity. The various derivatives thus synthesized were examined on their inhibitory activity on virus growth using a hemagglutinin (HA) method, leading to a discovery of promising candidates for new antiviral drugs having high activity and good therapeutic index.
Matsuya
Yuji
Y
Faculty of Pharmaceutical Sciences, and Department of Human Sciences and Fundamental Nursing, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
Sasaki
Kazushige
K
Nagaoka
Mamiko
M
Kakuda
Hiroko
H
Toyooka
Naoki
N
Imanishi
Nobuko
N
Ochiai
Hiroshi
H
Nemoto
Hideo
H
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D003500:Cyclization; D005663:Furans / Q000737:chemistry*; D000882:Haplorhini; D006386:Hemagglutination Tests; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology; D007668:Kidney; D015394:Molecular Structure
D000998:Antiviral Agents; D005663:Furans; D006576:Heterocyclic Compounds, 4 or More Rings; C039281:furan