Assembling the mitochondrial outer membrane.
The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.
Pfanner
Nikolaus
N
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany. Nikolaus.Pfanner@biochemie.uni-freiburg.de <Nikolaus.Pfanner@biochemie.uni-freiburg.de>
Wiedemann
Nils
N
Meisinger
Chris
C
Lithgow
Trevor
T
D000255:Adenosine Triphosphate / Q000378:metabolism; D017209:Apoptosis; D003600:Cytosol / Q000378:metabolism; D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology*; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism; D021381:Protein Transport
D005656:Fungal Proteins; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; D010940:Plant Proteins; D000255:Adenosine Triphosphate