[A virological description of serous meningitis in children immunized with vaccine against epidemic parotitis].
The morbidity structure was analyzed in children vaccinated against epidemic parotitis in 1993-2002. Eight children (4 with serous meningitis and 4 with lesions of the salivary glands) underwent virologic and immunologic examinations. The molecular typing of the SH-gene fragment of the parotitis virus showed the process in 7 cases to be provoked by the vaccination strain. Presumedly, progressing vaccine-associated meningitis inhibits antibody formation. The total incidence of vaccine-associated meningitis was shown, according to Saint Petersburg data, to be not high, which testifies to a low reactogenicity of the Russian vaccine strain.
Goleva
O V
OV
Kharit
S M
SM
Cherniaeva
T V
TV
Aksenov
O A
OA
Davidkin
I
I
Kolyshkin
V M
VM
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015994:Incidence; D007223:Infant; D008581:Meningitis / Q000097:blood / Q000209:etiology*; D009107:Mumps / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000009:adverse effects*; D010802:Phylogeny; D012189:Retrospective Studies; D019213:Rubulavirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D012426:Russia / Q000453:epidemiology; D012469:Salivary Glands / Q000473:pathology / Q000821:virology; D014505:Urban Population; D014611:Vaccination / Q000009:adverse effects*; D014764:Viral Proteins / Q000235:genetics
D000914:Antibodies, Viral; D000956:Antigens, Viral; D009108:Mumps Vaccine; D014764:Viral Proteins; C067386:small hydrophobic protein, Mumps virus