title: Monodisperse chitosan nanoparticles for mucosal drug delivery.
abstract: Chitosan nanoparticles (CS NPs) of a controlled size (below 100 nm) and narrow size distribution were obtained through the process of ionic gelation between CS and sodium tripolyphosphate (TPP). A high degree of CS deacetylation and narrow polymer molecular weight distribution were demonstrated to be critical for the controlling particle size distribution. Properties of the CS NPs were examined at different temperatures, values of pH, and ratios of CS to TPP. The model protein, bovine serum albumin, was encapsulated into the NPs, and the in vitro release profiles were examined in physiologically relevant media at 37 degrees C.
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Megan
authors.initials: M
authors.lastname: Oh
authors.forename: Christine
authors.initials: C
authors.lastname: Allen
authors.forename: Eugenia
authors.initials: E
authors.lastname: Kumacheva
mesh_terms: D000818:Animals; D002417:Cattle; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D007477:Ions; D007700:Kinetics; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D009092:Mucous Membrane / Q000187:drug effects*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011122:Polyphosphates / Q000737:chemistry; D012709:Serum Albumin / Q000008:administration & dosage / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors
chemical_list: D007477:Ions; D011122:Polyphosphates; D012709:Serum Albumin; D048271:Chitosan; C005692:triphosphoric acid