title: DINE (damage induced neuronal endopeptidase).
abstract: A unique central nervous system (CNS)-specific metalloprotease, DINE/ECEL1 (damage induced neuronal endopeptidase/ endothelin converting enzyme-like 1), has recently been added to the M13/neprilysin (NEP) family. This enzyme was identified by two groups independently using different approaches. In this review, we introduce the characteristics of DINE/ECEL1 and focus on the mechanism underlying the transcriptional regulation of DINE in response to neuronal injury.
authors.affiliation: Department of Anatomy and Neurobiology, Osaka City University, Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585, Japan.
authors.forename: Sumiko
authors.initials: S
authors.lastname: Kiryu-Seo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyama
mesh_terms: D000818:Animals; D006259:Craniocerebral Trauma / Q000378:metabolism; D008666:Metalloendopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism; D017434:Protein Structure, Tertiary
chemical_list: D008666:Metalloendopeptidases; C407822:damage-induced neuronal endopeptidase