Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia.
Reports on the prognostic impact of mutations in the RAS proto-oncogenes in patients with acute myeloid leukemia (AML) are conflicting. A peptide nucleic acid (PNA)-based technique was used on 232 AML samples to detect point mutations of the hotspots in N-RAS and K-RAS. No significant correlations between RAS mutations and clinical features, karyotype or FLT3 were found.
Ritter
Markus
M
Kim
Theo Daniel
TD
Lisske
Petra
P
Thiede
Christian
C
Schaich
Markus
M
Neubauer
Andreas
A
D000208:Acute Disease; D000328:Adult; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000235:genetics*; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D017354:Point Mutation; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic