title: Lupus erythematosus tumidus.
abstract: BACKGROUND
  Lupus erythematosus tumidus (LET) is a rare form of chronic cutaneous lupus erythematosus that characteristically presents as a succulent, erythematous plaques on sun-exposed areas. The histopathological change that primarily distinguishes LET from other variants of cutaneous lupus erythematosus is the lack of alterations of the dermo-epidermal junction and epidermis. Our purpose was to describe 15 cases of LET from Thailand.
  
  
  METHODS
  The records of 15 patients diagnosed with LET at Srinagarind Hospital Medical School between 1995 and 2002 were reviewed on the following aspects: clinical manifestation, laboratory investigation, direct immunofluorescence study, phototesting, histopathological findings, clinical course, and treatment.
  
  
  RESULTS
  All 15 patients consisted of 10 females and five males. The mean age at onset was 38.8 years. The lesions more commonly affect the face and trunk. One patient had concomitant discoid lupus erythematosus and two developed systemic involvement 4 and 6 months after LET. Direct immunofluorescence studies all showed negative results. Positive phototest reactions were detected in five of 10 tested patients: four with ultraviolet A and B and one with ultraviolet A only. Most patients responded well to chloroquine phosphate and the remainder successfully improved with methotrexate, topical and systemic corticosteroids.
  
  
  CONCLUSIONS
  Our data demonstrate the features of LET that are repeatable and characteristic. Lupus erythematosus tumidus in this study was more common in women, and photosensitivity reactions of the patients were seen less frequently compared with those in the earlier report of Kuhn et al. Furthermore, two of 15 patients exhibited systemic involvement in the course of their disease.
authors.affiliation: Division of Dermatology, Department of Medicine, Srinagarind Hospital Medical School, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. c_choonhakarn_dermatologist@hotmail.com
authors.forename: Charoen
authors.initials: C
authors.lastname: Choonhakarn
authors.forename: Aram
authors.initials: A
authors.lastname: Poonsriaram
authors.forename: Jaruwan
authors.initials: J
authors.lastname: Chaivoramukul
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies