Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis.
We investigated the serum macrophage migration inhibitory factor (MIF) levels of palmoplantar pustulosis patients, before and after the tonsillar provocation test. Higher serum MIF levels of palmoplantar pustulosis patients were decreased after the tonsillar provocation test (n=29). To confirm these phenomena, two patients with acute tonsillitis had their changes in body temperature, C-reactive protein (CRP) and serum MIF levels examined during the course of their illness. Surprisingly, increased MIF preceded fever and CRP elevation, and MIF subsequently decreased at the onset of fever and CRP elevation. Since MIF is an initiator of other proinflammatory cytokines, we suggest that the induction of MIF may precede other inflammatory conditions.
Shimizu
Tadamichi
T
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. michiki@med.hokudai.ac.jp
Niizeki
Hironori
H
Takeuchi
Osamu
O
Yamasaki
Yuichiro
Y
Inamoto
Nobuko
N
Kusunoki
Yukihiro
Y
Kobayashi
Kunihiko
K
Abe
Riichiro
R
Shimizu
Hiroshi
H
Nishikawa
Takeji
T
Hashiguchi
Kazuhiro
K
Nishihira
Jun
J
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001831:Body Temperature; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis* / Q000097:blood*; D008297:Male; D008872:Microwaves; D008875:Middle Aged; D014066:Palatine Tonsil / Q000528:radiation effects*; D011565:Psoriasis / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014069:Tonsillitis / Q000097:blood* / Q000503:physiopathology
D008263:Macrophage Migration-Inhibitory Factors; D002097:C-Reactive Protein