Immunological methods in the diagnosis of monoclonal gammopathies. The prognostic impact of the immunological data.
Immunological data are extremely important for the diagnosis of monoclonal gammopathies (MG). During the 1977-1998 period, 160 MG cases were diagnosed in our laboratory. Out of the 130 multiple myeloma (MM) cases, 70 (53.85%) met the strictly immunological criteria; in the rest of the cases, the immunological data had to be corroborated with the bone marrow cytology and bone X-ray data. We tried to assess retrospectively the prognostic impact of the immunological data on the 60 cases that were treated and followed at the Hematology Dept. of the Cancer Institute, Cluj. The following parameters were found to have a favorable prognostic impact on survival: IgG monoclonal component, kappa light chains, response to therapy with plateau phase achievement, Salmon Durie stages I and II at diagnosis.
Baldea
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L
Immunology Laboratory, Medical Clinic I, University of Medicine and Pharmacy, 3-5, Clinicilor Str., 3400 Cluj-Napoca, Romania.
Cucuianu
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A
Cristea
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A
D000970:Antineoplastic Agents / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000097:blood / Q000276:immunology* / Q000401:mortality; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
D000970:Antineoplastic Agents; D003404:Creatinine