title: Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and leukocyte chemotaxis.
abstract: Respiratory syncytial virus (RSV) is an important cause of severe lower respiratory tract illness in infants and the elderly. Presently, no safe and efficacious RSV vaccine exists; however, advances in our understanding of immunity and the pathogenesis of disease associated with RSV infection may lead to new vaccine strategies. RSV G protein contains a CX3C chemokine motif that interacts with the CX3CR1 chemokine receptor and modifies the activities of fractalkine. In the present study, we show that anti-RSV G protein antibody responses after recent RSV infection or vaccination are associated with inhibition of RSV G protein CX3C-CX3CR1 interaction and RSV G protein-mediated leukocyte chemotaxis.
authors.affiliation: National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Atlanta, GA, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Harcourt
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Karron
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Tripp
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis*; D001666:Binding Sites, Antibody; D000073883:CX3C Chemokine Receptor 1; D054428:Chemokine CX3CL1; D020523:Chemokines, CX3C / Q000737:chemistry / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007962:Leukocytes / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology*; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D022261:Respiratory Syncytial Virus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000073883:CX3C Chemokine Receptor 1; C515538:CX3CL1 protein, human; C095235:CX3CR1 protein, human; D054428:Chemokine CX3CL1; D020523:Chemokines, CX3C; D008565:Membrane Proteins; D019707:Receptors, Chemokine; D022261:Respiratory Syncytial Virus Vaccines; D014613:Vaccines, Attenuated; D014764:Viral Proteins