title: [A case of advanced non-small lung cancer responding to tumor suppressor p53 gene therapy].
abstract: The phase I study of the tumor suppressor p53 gene therapy for advanced lung cancer was performed. A 57-year-old man with locally advanced squamous cell carcinoma at the tracheal bifurcation, clinical stage IIIB, had previously been treated by radiotherapy and chemotherapy. Because of the local recurrence, he was enrolled to the study. He was treated by a local injection of ADVEXIN once every 4 weeks for 14 times without marked adverse events, which resulted in tumor regression and relief of his symptom for a year. In conclusion, gene therapy with ADVEXIN may be an effective treatment for locally advanced non-small lung cancer.
authors.affiliation: Center for Gene and Cell Therapy, Okayama University Hospital.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kagawa
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ohtani
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Toshiyoshi
authors.initials: T
authors.lastname: Fujiwara
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D016158:Genes, p53 / Q000235:genetics*; D015316:Genetic Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome