Synthesis of new N-sulfonylated amino alcohols and application to the enantioselective addition of diethylzinc to aldehydes.
A series of N-sulfonylated amino alcohols were prepared and the enantioselective addition of diethylzinc to aldehydes catalyzed by titanium(IV) complexes of those ligands were carried out. Excellent enantioselectivities were obtained for the desired alcohols with enantiomeric excess values up to 94% of R-configuration.
Hui
Xin-Ping
XP
Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan.
Chen
Chien-An
CA
Gau
Han-Mou
HM
D000447:Aldehydes / Q000737:chemistry*; D000605:Amino Alcohols / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000737:chemistry*
D000447:Aldehydes; D000605:Amino Alcohols; D009942:Organometallic Compounds; D013451:Sulfonic Acids; C454811:diethylzinc