Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists.
The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.
Cowart
Marlon
M
Department of Neuroscience Research, GPRD R4MN, Abbott Laboratories, AP9a/216, Abbott Park, IL 60073-6123, USA. marlon.d.cowart@abbott.com.
Altenbach
Robert
R
Black
Lawrence
L
Faghih
Ramin
R
Zhao
Chen
C
Hancock
Arthur A
AA
D000818:Animals; D001572:Benzofurans / Q000737:chemistry; D006633:Histamine Antagonists / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000737:chemistry; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D013329:Structure-Activity Relationship
D001572:Benzofurans; D006633:Histamine Antagonists; D007093:Imidazoles; D018100:Receptors, Histamine H3; C029899:imidazole; C105430:benzofuran