title: Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation.
abstract: The present paradigm of atherogenesis proposes that low density lipoproteins (LDL) are trapped in subendothelial space of the vascular wall where they are oxidized. Myeloperoxidase (MPO) plays a key role in oxidative damage. We propose that LDL oxidation by myeloperoxidase (Mox-LDL) could occur at the surface of the endothelial cells and not restricted to the subendothelial space. The triad constituted by endothelial cells, circulating LDL and MPO in close interaction, constitutes a synergic mechanism for the genesis of Mox-LDL.
authors.affiliation: Laboratoire de Médecine Expérimentale (ULB 222 Unit) ISPPC Hôpital Vésale, Montigny-Le-Tilleul, Belgium. kaveroes@hotmail.com
authors.forename: K
authors.initials: K
authors.lastname: Zouaoui Boudjeltia
authors.forename: N
authors.initials: N
authors.lastname: Moguilevsky
authors.forename: I
authors.initials: I
authors.lastname: Legssyer
authors.forename: S
authors.initials: S
authors.lastname: Babar
authors.forename: M
authors.initials: M
authors.lastname: Guillaume
authors.forename: P
authors.initials: P
authors.lastname: Delree
authors.forename: M
authors.initials: M
authors.lastname: Vanhaeverbeek
authors.forename: D
authors.initials: D
authors.lastname: Brohee
authors.forename: J
authors.initials: J
authors.lastname: Ducobu
authors.forename: C
authors.initials: C
authors.lastname: Remacle
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism*; D014471:Umbilical Veins / Q000166:cytology
chemical_list: D008077:Lipoproteins, LDL; D009195:Peroxidase