Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint.
Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-mitosis), a fact that has useful clinical ramifications. However, this delay is seldom permanent, and in the presence of an active SAC most cells ultimately escape mitosis and enter the next G1 as tetraploid cells. This review defines and discusses the various factors that determine how long a cell remains in mitosis when it cannot satisfy the SAC and also discusses the cell's subsequent fate.
Rieder
Conly L
CL
Division of Molecular Medicine, New York State Department of Health, Wadsworth Center, Albany, NY 12201, USA. reider@wadsworth.org
Maiato
Helder
H
D000818:Animals; D017209:Apoptosis; D016922:Cellular Senescence; D016193:G1 Phase; D006801:Humans; D018386:Kinetochores / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D009336:Necrosis; D015739:Nocodazole / Q000633:toxicity; D008941:Spindle Apparatus / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D015739:Nocodazole