title: Palladium 103 (103Pd) plaque radiation therapy for circumscribed choroidal hemangioma with retinal detachment.
abstract: OBJECTIVE
  To describe clinical experience with palladium 103 ((103)Pd) ophthalmic plaque radiotherapy for choroidal hemangioma.
  
  
  METHODS
  One course of (103)Pd ophthalmic plaque radiotherapy was used in each of 5 patients with circumscribed choroidal hemangioma who had progressive loss of vision due to subretinal exudation. A mean apex dose of 2900 cGy (2900 rad) was delivered. Functional tests of outcome included best-corrected visual acuity. Anatomic results included changes in tumor height and subretinal fluid documented by ophthalmoscopy, fluorescein angiography, and ultrasonography.
  
  
  RESULTS
  All patients had complete resolution of subretinal fluid with reattachment of the retina. All tumors decreased in height (mean, 50%) after treatment. Three patients (60%) demonstrated improvement in visual acuity at the last follow-up, and in 1 patient vision remained stable with resolution of metamorphopsia. Twenty-four months after treatment, 1 patient whose visual acuity had recovered from 20/160 to 20/32 had a loss of vision to 20/160 because of radiation maculopathy. For all patients, a mean visual acuity improvement of 2 lines was documented (95% confidence interval, 0.23-0.88). Mean follow-up was 18.6 months (range, 6-29 months).
  
  
  CONCLUSIONS
  A single (103)Pd plaque radiation treatment was effective in decreasing tumor height, eliminating subretinal fluid, and improving visual acuity in patients with symptomatic circumscribed choroidal hemangiomas.
authors.affiliation: Department of Ophthalmology, New York Eye Cancer Center, nd New York University School of Medicine, New York 10021, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Aizman
authors.forename: Paul T
authors.initials: PT
authors.lastname: Finger
authors.forename: Uri
authors.initials: U
authors.lastname: Shabto
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szechter
authors.forename: Anthony
authors.initials: A
authors.lastname: Berson
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D002830:Choroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006391:Hemangioma / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010165:Palladium / Q000627:therapeutic use*; D011446:Prospective Studies; D011868:Radioisotopes / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012163:Retinal Detachment / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D014463:Ultrasonography; D014792:Visual Acuity
chemical_list: D011868:Radioisotopes; D010165:Palladium