title: Membrane bound members of the M1 family: more than aminopeptidases.
abstract: In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad range of peptides down to only to a single peptide. This ability to either generate or degrade active peptide hormones is the focus of this review. In addition to their capacity to degrade a range of peptides a number of these aminopeptidases have novel functions that impact on cell signalling and will be discussed.
authors.affiliation: Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3010 Australia. albist@hfi.unimelb.edu.au
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Albiston
authors.forename: Siying
authors.initials: S
authors.lastname: Ye
authors.forename: Siew Yeen
authors.initials: SY
authors.lastname: Chai
mesh_terms: D000626:Aminopeptidases / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D018826:CD13 Antigens / Q000737:chemistry / Q000378:metabolism; D010122:Cystinyl Aminopeptidase; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D015778:Minor Histocompatibility Antigens; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D015778:Minor Histocompatibility Antigens; D000626:Aminopeptidases; C464841:ERAP1 protein, human; D018826:CD13 Antigens; D010122:Cystinyl Aminopeptidase; C105964:leucyl-cystinyl aminopeptidase; C023166:pyroglutamyl-peptidase II; D011761:Pyrrolidonecarboxylic Acid