Using eye movements to assess brain function in mice.
Examining eye movements is an important part of the neurological evaluation of humans; the distribution of the neural circuits that control these movements is such that they are disrupted--often in highly characteristic fashions--by many disease processes. Technical advances have made it possible to measure accurately the eye movements of mice, so it is now possible to use the detective power of eye movement recording to characterize neurological dysfunction in genetically altered strains. Here we introduce analytical tools used in ocular motor research and demonstrate their ability to reveal disorders of the visual pathways, inner ear, and cerebellum.
Stahl
John S
JS
Department of Neurology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA. jss6@po.cwru.edu
D000818:Animals; D001927:Brain Diseases / Q000503:physiopathology*; D004195:Disease Models, Animal; D005133:Eye Movements / Q000502:physiology*; D051379:Mice; D008818:Mice, Neurologic Mutants; D017120:Nystagmus, Optokinetic / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology