Biomimetic synthesis of the pyrrolobenzoxazine core of paeciloxazine.
Starting from a protected L-tryptophan derivative the pyrrolobenzoxazine core unit of paeciloxazine can be synthesized in two oxidation steps.
Schwaebisch
Dirk
D
Department of Chemistry, University of Oxford, Chemical Research Laboratory, UK.
Tchabanenko
Kirill
K
Adlington
Robert M
RM
Cowley
Andrew M
AM
Baldwin
Jack E
JE
D000969:Antinematodal Agents / Q000138:chemical synthesis*; D048588:Benzoxazines / Q000138:chemical synthesis*; D008956:Models, Chemical; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry*
D000969:Antinematodal Agents; D048588:Benzoxazines; D010078:Oxazines; C483751:paeciloxazine