[The formation of new blood vessels in coronary artery disease: where we are now].
New blood vessel formation is of great importance to clinicians and researchers because of its participation in many diseases. Scientists are trying to exploit the mechanisms of vasculogenesis, angiogenesis, and arteriogenesis in the treatment of coronary artery disease. These mechanisms are employed to improve myocardium vascularization in patients where both pharmacological therapy and available revascularization procedures (PTCA, CABG) are not effective. In such cases, factors including vascular endothelial growth factor (VEGF), acid fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), granulocyte/macrophage colony-stimulating factor (GM-CSF), and granulocyte colony stimulating factor (G-CSF), as well as stem cells, have been applied so far. This article is a review of the current knowledge about new blood vessel formation, especially in ischemic myocardium. We have also analyzed alternative strategies of treating coronary artery disease using the mechanisms of angiogenesis, arteriogenesis, and vasculogenesis.
Pawlak
Joanna
J
Zakład Anatomii Prawidłowej Człowieka Akademii Medycznej w Białymstoku.
Klim
Beata
B
Szkudlarek
Magdalena
M
Dziecioł
Janusz
J
D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000503:physiopathology*