title: Bonding efficacy and side effects of the high purity glyceryl mono-methacrylate.
abstract: The purpose of this study was to examine the efficacy of experimentally developed high purity glyceryl mono-methacrylate (GM) as a dentine primer and to evaluate the possibility of allergic reaction. The efficacy of experimental dentine primers was evaluated by measuring the polymerization contraction gap width and the tensile bond strength. Allergic reaction was evaluated by the guinea-pig maximization test. The skin reaction was evaluated according to the criteria of the International Contact Dermatitis Research Group. Contraction gap formation was completely prevented and the tensile bond strength was not significantly affected by priming with GM on high-purity GM. The allergic response decreased when high-purity GM was employed as the challenger. It was concluded that the clinical use of the high-purity GM is beneficial as the delayed allergic reaction could be avoided with no detrimental effect on the dentine bonding.
authors.affiliation: Department of Operative Dentistry, Showa University School of Dentistry, Ohta-Ward, Tokyo, Japan. ytaka@senzoku.showa-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: A
authors.initials: A
authors.lastname: Manabe
authors.forename: C
authors.initials: C
authors.lastname: Tani
authors.forename: H
authors.initials: H
authors.lastname: Hisamitsu
mesh_terms: D000818:Animals; D001840:Dental Bonding; D018772:Dental Marginal Adaptation; D017220:Dentin-Bonding Agents / Q000009:adverse effects / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology; D005989:Glycerides / Q000009:adverse effects / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D008689:Methacrylates / Q000009:adverse effects / Q000494:pharmacology*; D008963:Molar; D012867:Skin / Q000187:drug effects; D012882:Skin Tests; D013718:Tensile Strength
chemical_list: D017220:Dentin-Bonding Agents; D005989:Glycerides; D008689:Methacrylates; C069750:glyceryl methacrylate