[Evaluation of prophylactic hepatic arterial infusion chemotherapy after curative hepatectomy for metastatic colorectal cancer].
We evaluated the effect of hepatic arterial infusion (HAI) chemotherapy after curative resection of liver metastases of colorectal cancer. A total of 161 patients underwent curative resection of liver metastases. Among them, 50 patients underwent HAI of 5-FU, and 111 patients had no HAI therapy. The 50% disease-free survival time (50% DFS) was 758 days and 342 days in the HAI group and the non-HAI group (logrank test, p<0.01), and the 50% overall survival time (50% OS) was 978 days versus 730 days (p<0.05), respectively. Among the 71 patients with multiple resectable metastases (H2 or H3), the HAI group had a significantly superior 50% DFS. HAI therapy seems to be an effective form of adjuvant chemotherapy after hepatic resection of metastatic colorectal cancer.
Tokuoka
Masayoshi
M
Dept. of Surgery, National Hospital Organization Osaka National Hospital.
Kashiwazaki
Masaki
M
Takeda
Yutaka
Y
Hasuike
Yasunori
Y
Mishima
Hideyuki
H
Ikenaga
Masakazu
M
Masuda
Norikazu
N
Hirao
Motohiro
M
Fujitani
Kazumasa
K
Sawamura
Toshiro
T
Tsujinaka
Toshimasa
T
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005472:Fluorouracil / Q000008:administration & dosage*; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D008113:Liver Neoplasms / Q000401:mortality / Q000517:prevention & control* / Q000556:secondary*; D012189:Retrospective Studies
D000970:Antineoplastic Agents; D005472:Fluorouracil