title: Indocyanine green-assisted ILM peeling in macular hole surgery revisited.
abstract: OBJECTIVE
  To report visual outcomes after peeling of the internal limiting membrane (ILM) using a brief application of low dose indocyanine green (ICG) for macular hole repair.
  
  
  METHODS
  Prospective, nonrandomized interventional case series.
  
  
  METHODS
  A consecutive series of 16 eyes of 14 patients with full-thickness macular hole underwent vitrectomy and peeling of the ILM with an intravitreal application of 0.05% ICG for less than 10 seconds.
  
  
  RESULTS
  The ILM could be removed uneventfully in 5 of 16 cases after a single ICG application and in 11 cases after a second ICG application. The macular hole was closed in 15 (93.7%) of 16 cases after a single surgery and in one case after a repeat surgery, as evaluated by optical coherence tomography. A significant visual acuity improvement was achieved as the mean logarithm of the minimum angle of resolution was from 0.600 preoperatively (equivalent to approximately 5/20 in the conventional 20 foot numerator form) to 0.213 (12/20) at the end of follow-up (P < .0001). None of the cases developed peripheral visual field defect. Ophthalmoscopies or optic coherence tomographic images did not reveal any disruption at the level of the retinal pigment epithelium.
  
  
  CONCLUSIONS
  A brief intravitreal application of low dose ICG may provide a safe ILM peeling in vitreomacular surgeries.
authors.affiliation: Eye Care Nagoya, Nakamura-ku, Nagoya-shi, Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ando
authors.forename: Kumiko
authors.initials: K
authors.lastname: Sasano
authors.forename: Fukue
authors.initials: F
authors.lastname: Suzuki
authors.forename: Norio
authors.initials: N
authors.lastname: Ohba
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000473:pathology / Q000601:surgery; D004396:Coloring Agents; D019773:Epiretinal Membrane / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012167:Retinal Perforations / Q000175:diagnosis / Q000601:surgery*; D013194:Staining and Labeling / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green