title: [A case of gastric endocrine cell carcinoma with neck lymph node metastasis resected after neoadjuvant chemotherapy].
abstract: A relatively rare case of gastric endocrine cell carcinoma was reported. The prognosis of this disease appears to be very poor due to its rapid rate of growth and invasiveness. A 75-year-old woman underwent a gastric endoscopy because the patient complained of an appetite loss. A gross Borrmann 3 type lesion in the greater curvature of the fornix was found. Biopsy specimens showed endocrine cell carcinoma. Abdominal CT examination revealed metastases in left neck and paraaortic lymph nodes. The serum sample showed an elevation of NSE level to be 53. A combination chemotherapy was performed using cisplatin and etoposide, which resulted in remarkable reduction of the main tumor two months later. The total gastrectomy associated with D2 lymph node dissection was performed. However, abdominal tumor was observed again in a month and it progressed rapidly. No clear response to the chemotherapies with cisplatin/etoposide or paclitaxel was found. The patient died 5 months after the operation.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation Ohkubo Hospital.
authors.forename: Kumi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Michio
authors.initials: M
authors.lastname: Maruyama
authors.forename: Itaru
authors.initials: I
authors.lastname: Takashima
authors.forename: Shoji
authors.initials: S
authors.lastname: Maruyama
authors.forename: Ayaki
authors.initials: A
authors.lastname: Koide
authors.forename: Masahide
authors.initials: M
authors.lastname: Obu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shinoura
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Kato
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ebuchi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000473:pathology / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009333:Neck; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D005047:Etoposide; D002945:Cisplatin