A new DNA computing model for the NAND gate based on induced hairpin formation.
Hairpin structure of DNA molecules has been widely employed in a variety of biosensors and in nanoscale molecular assembly applications. For example, the well known molecular beacons can report the presence of specific nucleic acids in homogeneous solutions with high accuracy. Recently, Smith et al. proposed the induction of hairpin formation through sequence-specific binding of a small-molecule ligand to a G-G mismatch. Not only did this method offer great flexibility in controlling hairpin formation, more importantly the induced hairpin maintains high degree of sensitivity toward specific hybridization. In this contribution, we present a theoretical model for the logical NAND gate based on induced hairpin formation.
Liu
Wenbin
W
School of Computer Science and Engineering, Wenzhou Normal College, Wenzhou City 325027, China. wbliu@mail.hust.edu.cn
Shi
Xiaohong
X
Zhang
Shemin
S
Liu
Xiangrong
X
Xu
Jin
J
D003198:Computer Simulation; D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*; D016015:Logistic Models; D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D012815:Signal Processing, Computer-Assisted
D004247:DNA