title: Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction.
abstract: This study evaluated left ventricular diastolic function with Doppler echocardiography before and after statin therapy. Statin therapy worsened diastolic parameters in most patients; coenzyme Q(10) supplementation in patients with worsening diastolic function with statin therapy improved parameters of diastolic function.
authors.affiliation: Heart Failure Institute, Department of Medicine, Advocate Christ Medical Center, University of Illinois/Christ Cardiovascular Disease Fellowship Program, Oak Lawn, Illinois 60453, USA. marc.silver@advocatehealth.com <marc.silver@advocatehealth.com>
authors.forename: Marc A
authors.initials: MA
authors.lastname: Silver
authors.forename: Peter H
authors.initials: PH
authors.lastname: Langsjoen
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Szabo
authors.forename: Harish
authors.initials: H
authors.lastname: Patil
authors.forename: Allan
authors.initials: A
authors.lastname: Zelinger
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D000069059:Atorvastatin; D003067:Coenzymes; D015150:Echocardiography, Doppler; D005260:Female; D006538:Heptanoic Acids / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000009:adverse effects / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D003067:Coenzymes; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D014451:Ubiquinone; D000069059:Atorvastatin; C024989:coenzyme Q10