Molecular mechanisms and drug development in aquaporin water channel diseases: the translocation of aquaporin-5 from lipid rafts to the apical plasma membranes of parotid glands of normal rats and the impairment of it in diabetic or aged rats.
Salivary secretion from rat salivary glands occurs in response to stimulation by acetylcholine and norepinephrine released from nerve endings. Aquaporin-5 (AQP5) localizes in lipid rafts under control conditions and is induced to traffic to the apical plasma membrane in interlobular ducts of rat parotid glands by the activation of M3 muscarinic acetylcholine receptors or alpha1-adrenoceptors. This review will focus on the mechanisms of the translocation of AQP5 from lipid rafts to the apical plasma membrane in the interlobular duct cells of parotid glands of normal rats and the impairment of its translocation in diabetic or senescent rats.
Ishikawa
Yasuko
Y
Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. isikawa@dent.tokushima-u.ac.jp
Inoue
Noriko
N
Zhenfang
Yuan
Y
Nakae
Yoshiko
Y
D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D051402:Aquaporin 5; D020346:Aquaporins / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D043587:Receptor, Muscarinic M3 / Q000378:metabolism
C496036:AQP5 protein, human; C496040:Aqp5 protein, rat; D051402:Aquaporin 5; D020346:Aquaporins; D008565:Membrane Proteins; D043587:Receptor, Muscarinic M3