title: Wear particulate and osteolysis.
abstract: Total joint replacements of the hip and knee are generally highly successful, with satisfactory longevity and clinical results. Using modern biocompatible materials, optimal component design, and meticulous surgical technique, survivorship of cemented or cementless joint replacements is approximately 15 years with more than a 90% probability. The host's biologic response is critical to implant longevity. Particulate disease refers to the host's adverse biologic response to wear debris and byproducts generated from the prosthesis. Initially, emphasis was placed on particulate polymethylmethacrylate (cement disease), but more recently polyethylene wear debris has been underscored. Debris from several materials in sufficient quantities and physicochemical forms, however, can generate an inflammatory cascade resulting in periprosthetic bone destruction (osteolysis), jeopardizing long-term success of the implant.
authors.affiliation: Department of Orthopaedic Surgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA. goodbone@stanford.edu
authors.forename: Stuart
authors.initials: S
authors.lastname: Goodman
mesh_terms: D001843:Bone Cements / Q000009:adverse effects*; D005549:Foreign-Body Reaction / Q000209:etiology / Q000276:immunology / Q000473:pathology; D006801:Humans; D010014:Osteolysis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D019904:Polymethyl Methacrylate / Q000009:adverse effects*; D011475:Prosthesis Failure
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate