title: Sinus floor augmentation with simultaneous placement of dental implants in the presence of platelet-rich plasma or recombinant human bone morphogenetic protein-7.
abstract: The aim of the present study was to evaluate the possible benefit of platelet-rich plasma (PRP) in sinus grafting as compared with recombinant human bone morphogenetic protein-7 (rhBMP-7). For this purpose, we performed a bilateral sinus augmentation with anorganic bovine bone and simultaneous insertion of a titanium screw implant in five miniature pigs. Six hundred microliters of PRP and 15%-vol. autologous bone, which was collected with a trap during preparation of the implant recipient site, were added to the right sinus and 420 microl rhBMP-7 to the left sinus. A polychrome sequential labeling was performed. The animals were sacrificed 6 weeks after surgery. Undecalcified ground sections were evaluated by microradiography, digitized histomorphometry and under fluorescent light. The mean bone-implant contact using rhBMP-7 was 45.8% and 5.7% under PRP (P=0.002). The mean height of newly mineralized bone in the augmented area using rhBMP-7 amounted to 8.3 mm as opposed to 3.6 mm under PRP (P=0.013). Using PRP, the mean area of the newly formed bone was enhanced (51.3%) as compared with rhBMP-7 (33.1%); however, this difference was not statistically significant (P=0.081). In conclusion, under the selected experimental conditions the use of rhBMP-7 led to superior outcomes with regard to the osseointegration of dental implants and the height of new bone as compared with the use of PRP.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Schleswig-Holstein, Campus Kiel, Germany. roldan@mkg.uni-kiel.de
authors.forename: J Camilo
authors.initials: JC
authors.lastname: Roldán
authors.forename: Søren
authors.initials: S
authors.lastname: Jepsen
authors.forename: Christian
authors.initials: C
authors.lastname: Schmidt
authors.forename: Helge
authors.initials: H
authors.lastname: Knüppel
authors.forename: David C
authors.initials: DC
authors.lastname: Rueger
authors.forename: Yahya
authors.initials: Y
authors.lastname: Açil
authors.forename: Hendrik
authors.initials: H
authors.lastname: Terheyden
mesh_terms: D000818:Animals; D001792:Blood Platelets; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage*; D002417:Cattle; D015921:Dental Implants; D008443:Maxillary Sinus / Q000187:drug effects / Q000601:surgery*; D016348:Osseointegration / Q000187:drug effects*; D010949:Plasma / Q000166:cytology; D013552:Swine; D013556:Swine, Miniature
chemical_list: D019485:Bone Morphogenetic Proteins; D015921:Dental Implants