title: Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.
abstract: A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Via P. Giuria 9, I-10125 Torino, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Cena
authors.forename: Donatella
authors.initials: D
authors.lastname: Boschi
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Tron
authors.forename: Kostantin
authors.initials: K
authors.lastname: Chegaev
authors.forename: Loretta
authors.initials: L
authors.lastname: Lazzarato
authors.forename: Antonella
authors.initials: A
authors.lastname: Di Stilo
authors.forename: Manuela
authors.initials: M
authors.lastname: Aragno
authors.forename: Roberta
authors.initials: R
authors.lastname: Fruttero
authors.forename: Alberto
authors.initials: A
authors.lastname: Gasco
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001161:Arteriosclerosis / Q000517:prevention & control*; D001205:Ascorbic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005296:Ferrous Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010656:Phenylephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D000975:Antioxidants; D005296:Ferrous Compounds; D000960:Hypolipidemic Agents; D008563:Membrane Lipids; D020030:Nitric Oxide Donors; D010636:Phenols; D017392:Thiobarbituric Acid Reactive Substances; D010656:Phenylephrine; D001205:Ascorbic Acid