Clear cell sarcoma associated with multiple pulmonary metastases with structural and numerical karyotypic changes.
Cytogenetic analysis was performed on a specimen from a pulmonary metastasis of clear cell sarcoma originated on the right ankle of a 53-year-old Japanese woman. It revealed near-triploid with several numerical changes including abnormalities in the copy number of chromosomes 7, 8, and 22, and structural abnormalities of chromosome 22 and others. This is a minor case which showed the multiple abnormalities of chromosomes in the absence of a t (12;22) translocation.
Kato
N
N
Department of Dermatology and Clinical Research Institute, Hokkaido Cancer Center, Sapporo, Japan. kato@sap-cc.go.jp
Mizuno
O
O
Tamura
A
A
Yamanaka
Y
Y
Tanimura
S
S
Minakawa
H
H
D000842:Ankle; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics* / Q000556:secondary*; D008875:Middle Aged; D018227:Sarcoma, Clear Cell / Q000235:genetics* / Q000473:pathology / Q000556:secondary*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology