title: Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients.
abstract: We studied the role of cytochrome P4501A1 (CYP1A1 Val/Val) genotypes in the etiology of acute lymphoblastic leukemia (ALL) in adult Mexican patients. Distributions of CYP1A1 Val/Val genotypes in peripheral blood DNA samples from 136 healthy controls and 136 adult patients with ALL were evaluated. There was an increased frequency of the CYP1A1 Val/Val genotype among ALL patients, showing a significant association between this genotype and the risk of developing ALL.
authors.affiliation: División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Guadalajara, Jalisco, México. marthaga@foreigner.class.udg.mx
authors.forename: M P
authors.initials: MP
authors.lastname: Gallegos-Arreola
authors.forename: C M
authors.initials: CM
authors.lastname: Batista-González
authors.forename: J L
authors.initials: JL
authors.lastname: Delgado-Lamas
authors.forename: L E
authors.initials: LE
authors.lastname: Figuera
authors.forename: A M
authors.initials: AM
authors.lastname: Puebla-Pérez
authors.forename: L
authors.initials: L
authors.lastname: Arnaud-López
authors.forename: V
authors.initials: V
authors.lastname: Peralta-Leal
authors.forename: L J
authors.initials: LJ
authors.lastname: Ramírez-Jirano
authors.forename: G M
authors.initials: GM
authors.lastname: Zúñiga-González
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
chemical_list: D019363:Cytochrome P-450 CYP1A1