Absence of secretory endometrium after false-positive home urine luteinizing hormone testing.
OBJECTIVE
To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing.


METHODS
Multicenter clinical trial of the usefulness of endometrial biopsy in the evaluation of infertility, with women from fertile and infertile couples randomly assigned to midluteal vs. late luteal phase endometrial sampling.


METHODS
Twelve clinical sites of the National Institutes of Health/National Institute of Child Health and Human Development-sponsored Reproductive Medicine Network.


METHODS
All women in the study had regular menstrual cycles. Fertile volunteers who had delivered a live born infant within the past 2 years without medical intervention were recruited through advertisements at participating sites. Infertile women with regular cycles were recruited from the clinical practices of the sites' physicians.


METHODS
Interview, informed consent, subject-interpreted home urine LH testing, and endometrial biopsy in either the midluteal or late luteal phase.


METHODS
Proportion of cases with proliferative endometrium on biopsy.


RESULTS
In both fertile and infertile women, more than 7% of endometrial biopsies performed 7-13 days after a positive home urine LH test revealed proliferative endometrium.


CONCLUSIONS
Patient interpretation of home urine LH test kits not uncommonly results in false-positive tests. Women planning menstrual cycle testing or procedures related to ovulation may benefit from additional confirmatory testing.
McGovern
Peter G
PG
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA. mcgovepg@umdnj.edu
Myers
Evan R
ER
Silva
Susan
S
Coutifaris
Christos
C
Carson
Sandra A
SA
Legro
Richard S
RS
Schlaff
William D
WD
Carr
Bruce R
BR
Steinkampf
Michael P
MP
Giudice
Linda C
LC
Leppert
Phyllis C
PC
Diamond
Michael P
MP
D000328:Adult; D001706:Biopsy; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000473:pathology* / Q000652:urine*; D007986:Luteinizing Hormone / Q000652:urine*; D015588:Observer Variation; D012648:Self Care
D007986:Luteinizing Hormone