Angiogenic strategy for human ischemic heart disease: brief overview.
In the Western World ischemic coronary disease is the leading cause of morbidity and mortality. Therapeutic approaches mostly aim to restore flow to a localized segment by angioplasty or bypass surgery. Therapeutic angiogenesis and or arteriogenesis describes a strategy where blood vessel formation is induced for the purposes of treating and/or preventing ischemic disease. At present, at least 17 clinical trials of myocardial angiogenesis have been presented involving over 900 patients. Therapeutic angiogenesis makes use of the administration of angiogenic growth factor protein or gene to promote the development of endogenous collateral vessels in ischemic myocardium. Most recently, interest has grown in the potential angiogenesis effects of cell therapy--such as autologous bone marrow cells or cultured stem cells--and there are now several groups initiating phase I/II trials in this area.
Fukuda
Shoji
S
Department of Surgery, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan.
Yoshii
Shinpei
S
Kaga
Shigeaki
S
Matsumoto
Masahiko
M
Kugiyama
Kiyotaka
K
Maulik
Nilanjana
N
D000818:Animals; D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000628:therapy*; D015316:Genetic Therapy; D006331:Heart Diseases / Q000628:therapy; D006801:Humans; D017202:Myocardial Ischemia; D009204:Myocardial Revascularization; D032383:Myocytes, Cardiac / Q000378:metabolism; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D033581:Stem Cell Transplantation