Investigation into the mast cell stabilizing activity of nature-identical and synthetic indanones.
As part of an ongoing search for novel molecules with therapeutic potential we examined the mediator release inhibition activity of a number of indanones and their derivatives. The aldol condensation product 18 was approximately twice as potent as disodium cromoglycate as an inhibitor of compound 48/80-stimulated histamine release from rat peritoneal mast cells. The activity of this class of dimeric indanone compound is significantly higher than controls and may represent a new class of mast cell stabilizing agents. Compound 18 has been selected for further biological evaluation of its mast cell stabilization profile.
Frankish
Neil
N
School of Pharmacy, Panoz Institute, Trinity College, Dublin 2, Ireland. nfrnkish@tcd.ie
Farrell
Ronan
R
Sheridan
Helen
H
D000818:Animals; D005260:Female; D007189:Indans / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010537:Peritoneum / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar
D007189:Indans