title: [Persistent hyperinsulinemic hypoglycemia. Two case reports].
abstract: We report two cases of infants who presented seizures and persistent hypoglycemia. In both infants, we established diagnosis of persistent hypoglycemia by hyperinsulinism (PHH); glycemic/insulinic ratio was > 0.3, and we found no pancreatic changes by means of other diagnostic procedures. The medical treatment consisted of hydrocortisone, diazoxide, and octreotide without response. Definitive treatment made was sub-total pancreatectomy; postoperatory evolution was satisfactory, and the histologic report showed changes in Langerhans islet of nesidioblastosis. We conclude that PHH and glucose/insulin ratio > 0.3 indicates that surgical treatment with pancreatectomy should not be delayed.
authors.affiliation: Servicio de Medicina Interna, Hospital Infantil del Estado de Sonora. nsotelo@hmo.megared.net.mx
authors.forename: Norberto
authors.initials: N
authors.lastname: Sotelo-Cruz
authors.forename: Andrés
authors.initials: A
authors.lastname: Cordero-Olivares
authors.forename: Carlos
authors.initials: C
authors.lastname: Ramírez-Rodríguez
authors.forename: Guillermo
authors.initials: G
authors.lastname: López-Cervantes
authors.forename: Jaime
authors.initials: J
authors.lastname: Hurtado-Valenzuela
authors.forename: Brenda María
authors.initials: BM
authors.lastname: López-Cervantes
mesh_terms: D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D007003:Hypoglycemia / Q000150:complications*; D007223:Infant; D007231:Infant, Newborn; D008297:Male