title: Overexpression of Her2/neu is observed in one third of adult acute lymphoblastic leukemia patients and is associated with chemoresistance in these patients.
abstract: Among 100 patients with acute lymphoblastic leukemia (ALL), 15 B-ALL patients were found positive for surface Her2/neu expression. The incidence in children was only 3.4% compared to 31% in adults (p=0.001). Considering only adult B-ALL patients (n=38), surface Her2/neu expression was associated with chemoresistance (50% versus 11%, p=0.03) suggesting that it could be a prognostic marker of poor clinical outcome in ALL.
authors.forename: Patrice
authors.initials: P
authors.lastname: Chevallier
authors.forename: Nelly
authors.initials: N
authors.lastname: Robillard
authors.forename: Soraya
authors.initials: S
authors.lastname: Wuilleme-Toumi
authors.forename: Françoise
authors.initials: F
authors.lastname: Méchinaud
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Harousseau
authors.forename: Hervé
authors.initials: H
authors.lastname: Avet-Loiseau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D018734:Genes, erbB-2; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000503:physiopathology*