Zinc transporter LIV-1: a link between cellular development and cancer progression.
Genes involved in normal developmental processes often have a role in tumour progression. Epithelial-mesenchymal transition (EMT) is a general phenomenon that is an essential event in embryonic development, tissue remodelling and wound repair. Genes that regulate EMT are attracting significant attention as mediators of tumour progression. Indeed, EMT is considered an important event during the evolution of malignant tumours and their progression to metastasis, with several reports of molecules involved in this process facilitating migration and invasion of epithelial tumour cells. Recent work linking the zinc transporter LIV-1 with the transcription factors STAT3 and Snail in zebrafish embryogenesis, throws new light on this transition and has important implications for the development of cancer.
Taylor
Kathryn M
KM
Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff CF10 3XF, Wales, UK. Taylorkm@cardiff.ac.uk
Hiscox
S
S
Nicholson
R I
RI
D000818:Animals; D027682:Cation Transport Proteins / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology; D018450:Disease Progression; D047108:Embryonic Development; D004848:Epithelium; D006801:Humans; D008648:Mesoderm; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology*; D050796:STAT3 Transcription Factor; D000071250:Snail Family Transcription Factors; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D015027:Zebrafish; D029961:Zebrafish Proteins
D027682:Cation Transport Proteins; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C418627:SLC39A6 protein, human; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D000071250:Snail Family Transcription Factors; D015534:Trans-Activators; D014157:Transcription Factors; D029961:Zebrafish Proteins; C494089:stat3 protein, zebrafish