[Common variable immunodeficiency and celiac disease].
Variable immunodeficiency is frequently associated with subtotal villous atrophy, unchanged by gluten free diet. We report two cases of common variable immunodeficiency associated with chronic symptoms of malabsorption due to total villous atrophy. Symptoms of malabsorption disappeared and histological abnormalities improved after a gluten free diet. The association between celiac disease and common variable immunodeficiency should not be considered as fortuitous. Clinicians should be aware of this association and of the low sensitivity of serologic testing in this setting.
Béchade
Dominique
D
Service de Clinique Médicale, Hôpital du Val de Grâce, 74 boulevard de Port Royal, 75230 Paris Cedex 05. bechade.dominique@wanadoo.fr
Desramé
Jérôme
J
De Fuentès
Gilles
G
Camparo
Philippe
P
Raynaud
Jean-Jacques
JJ
Algayres
Jean-Pierre
JP
D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy / Q000276:immunology* / Q000473:pathology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000473:pathology; D005983:Glutens; D006801:Humans; D008297:Male; D008875:Middle Aged
D005983:Glutens