Pediatric hepatic angiosarcoma: case report and review of the literature.
Pediatric hepatic angiosarcoma (PHAS) is a rare tumor, which usually presents as a rapid enlargement of the liver. To date, surgery, chemotherapy, and radiotherapy have not improved the poor prognosis of PHAS with only three survivors reported. The histology of PHAS is distinct from adult angiosarcoma, because PHAS displays hypercellular whorls of sarcomatous cells, or "kaposiform" spindle cells, in addition to the general features of angiosarcoma. We report a case of PHAS that was treated with vascular ablation, chemotherapy, and liver transplantation. Lung metastases occurred 14 months posttransplant.
Dimashkieh
Haytham H
HH
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.
Mo
Jun Q
JQ
Wyatt-Ashmead
Josephine
J
Collins
Margaret H
MH
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004621:Embolization, Therapeutic; D005260:Female; D006394:Hemangiosarcoma / Q000556:secondary* / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy*; D016031:Liver Transplantation; D008175:Lung Neoplasms / Q000556:secondary; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents