Expression of mismatch repair proteins in invasive and in situ carcinoma of the breast.
BACKGROUND
Genetic instability is a characteristic feature of familial and sporadic breast carcinomas. It is not clear whether defects in the mismatch repair system accompany this instability. The purpose of this study was to explore the expression of two of the proteins encoded by the DNA mismatch repair genes, namely MLH1 and MSH2, in sporadic in situ and invasive breast carcinomas of various types and grades occurring in Greek patients.


METHODS
MLH1 and MSH2 expression was monitored immunohistochemically in 60 breast carcinomas (20 in situ and 40 invasive). RESULTS-CONCLUSION: Although we did not detect loss of MLH1 or MSH2 expression, we do believe that our data will contribute to a better understanding of the role of the mismatch repair (MMR) system in breast cancer.
Batistatou
Anna
A
Department of Pathology, University of Ioannina, Medical School, 451 10, Ioannina, Greece.
Arkoumani
Evdokia
E
Stefanou
Dimitrios
D
D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002278:Carcinoma in Situ / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein; D009363:Neoplasm Proteins / Q000378:metabolism*; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; C501486:MLH1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein