title: Do the serum oxidative stress biomarkers provide a reasonable index of the general oxidative stress status?
abstract: The oxidant status of an individual is assessed by determining a group of markers in noninvasive samples. One limitation when measuring these biomarkers is that they do not give information about tissue localization of oxidative stress. The present study was undertaken to establish whether the serum oxidative stress biomarkers are indicative of oxidative stress in tissues of an individual. To accomplish this, we determined a few generic markers of oxidation in serum and tissues of six groups of rats treated experimentally, to modulate their oxidative stress status. The correlation between serum and tissue levels was calculated for each marker. Also, for each tissue, the correlation between the values of these oxidative stress biomarkers was analysed. Our results show that only lipid peroxides in serum could be useful to predict the oxidative stress in tissues. No correlation was found between any of the oxidative stress markers in serum.
authors.affiliation: Departamento de Bioquímica, Bromatología y Toxicología, Facultad de Farmacia, Universidad de Sevilla, Spain.
authors.forename: Sandro
authors.initials: S
authors.lastname: Argüelles
authors.forename: Sonia
authors.initials: S
authors.lastname: García
authors.forename: Mariam
authors.initials: M
authors.lastname: Maldonado
authors.forename: Alberto
authors.initials: A
authors.lastname: Machado
authors.forename: Antonio
authors.initials: A
authors.lastname: Ayala
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology; D003676:Deferoxamine / Q000494:pharmacology; D007501:Iron / Q000378:metabolism; D000090463:Iron Deficiencies; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D017895:Manganese Compounds / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D015415:Biomarkers; D002712:Chlorides; D017895:Manganese Compounds; D017392:Thiobarbituric Acid Reactive Substances; D007501:Iron; D003676:Deferoxamine; C025340:manganese chloride