ARC channels: a novel pathway for receptor-activated calcium entry.
In many nonexcitable cells, stimulation with low agonist concentrations specifically activates Ca2+ entry via arachidonic acid-regulated, highly Ca2+-selective ARC channels. Only at high agonist concentrations are the more widely studied store-operated channels activated, producing sustained elevated cytosolic Ca2+ concentration signals. These signals activate calcineurin, which in turn inhibits the ARC channels, resulting in a "reciprocal regulation" of these two distinct Ca2+-entry pathways that may have important functional implications for the cell.
Shuttleworth
Trevor J
TJ
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA. trevor_shuttleworth@urmc.rochester.edu
Thompson
Jill L
JL
Mignen
Olivier
O
D000818:Animals; D016718:Arachidonic Acid / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*
D015220:Calcium Channels; D016718:Arachidonic Acid