title: Structural neural networks subserving oculomotor function in first-episode schizophrenia.
abstract: BACKGROUND
  Smooth pursuit and antisaccade abnormalities are well documented in schizophrenia, but their neuropathological correlates remain unclear.
  
  
  METHODS
  In this study, we used statistical parametric mapping to investigate the relationship between oculomotor abnormalities and brain structure in a sample of first-episode schizophrenia patients (n = 27). In addition to conventional volumetric magnetic resonance imaging, we also used magnetization transfer ratio, a technique that allows more precise tissue characterization.
  
  
  RESULTS
  We found that smooth pursuit abnormalities were associated with reduced magnetization transfer ratio in several regions, predominantly in the right prefrontal cortex. Antisaccade errors correlated with gray matter volume in the right medial superior frontal cortex as measured by conventional magnetic resonance imaging but not with magnetization transfer ratio.
  
  
  CONCLUSIONS
  These preliminary results demonstrate that specific structural abnormalities are associated with abnormal eye movements in schizophrenia.
authors.affiliation: Institute of Neurology, University College London, Queens Square, London WC1N 3BG, United Kingdom.
authors.forename: Manjinder S
authors.initials: MS
authors.lastname: Bagary
authors.forename: Samuel B
authors.initials: SB
authors.lastname: Hutton
authors.forename: Mark R
authors.initials: MR
authors.lastname: Symms
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Barker
authors.forename: Stanley H
authors.initials: SH
authors.lastname: Mutsatsa
authors.forename: Thomas R E
authors.initials: TR
authors.lastname: Barnes
authors.forename: Eileen M
authors.initials: EM
authors.lastname: Joyce
authors.forename: Maria A
authors.initials: MA
authors.lastname: Ron
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D011698:Pursuit, Smooth / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology