Coordination of cell death and the cell cycle: linking proliferation to death through private and communal couplers.
In development and in the adult, complex signaling pathways operate within and between cells to coordinate proliferation and cell death. These networks can be viewed as coupling devices that link engines driving the cell cycle and the initiation of apoptosis. We propose three simple frameworks for modeling the effects of proliferative drive on apoptotic propensity. This perspective offers a potentially useful foundation for predicting group behaviors of cells in normal and pathological settings.
Abrams
John M
JM
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA. John.Abrams@utsouthwestern.edu
White
Michael A
MA
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D016923:Cell Death; D049109:Cell Proliferation; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction