title: The effect of meat products enriched with plant sterols and minerals on serum lipids and blood pressure.
abstract: The purpose of the study was to investigate the effect of non-esterified plant sterol-enriched and mineral-enriched low-fat and low-salted meat products compared with control meat products, on serum total and lipoprotein lipids and blood pressure in subjects with mildly to moderately elevated serum cholesterol concentration. A randomised, placebo-controlled, single-blind, repeated measure design was used. Altogether 21 volunteers completed the study. The study began with a pre-trial period of 1-2 weeks, which was followed by three different test periods in the following order: meat products enriched with plant sterols (1.2 g/day), potassium, calcium and magnesium (MP1); meat products with no added plant sterols and minerals (control); and meat products with plant sterols (2.1 g/day), potassium, calcium and magnesium (MP2). Each test period lasted for 3 weeks. During the MP2 period, the serum total and low-density lipoprotein cholesterol concentration decreased 4.9+/-7.5% (P<0.05) and 4.6+/-11.3% (not significant), respectively, compared with the control period. No differences in the high-density lipoprotein cholesterol and total triglyceride concentrations or in systolic blood pressure and diastolic blood pressure were found among the test periods. In conclusion, the present study showed that frankfurters and cold cuts enriched with plant sterols from tall oil, potassium, calcium and magnesium, as part of habitual Finnish diet reduced the serum total cholesterol concentration in hypercholesterolemic subjects when the intake of sitosterols was 2.1 g/day, but not with the lower dose.
authors.affiliation: Oy Foodfiles Ltd (Contract Research Organization) Neulaniementie 70210 2 L 6, Kuopio, Finland. niina.tapola@foodfiles.com
authors.forename: Niina S
authors.initials: NS
authors.lastname: Tapola
authors.forename: Mari L
authors.initials: ML
authors.lastname: Lyyra
authors.forename: Henna M
authors.initials: HM
authors.lastname: Karvonen
authors.forename: Matti I
authors.initials: MI
authors.lastname: Uusitupa
authors.forename: Essi S
authors.initials: ES
authors.lastname: Sarkkinen
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004032:Diet; D002149:Energy Intake; D005260:Female; D005527:Food, Fortified; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008461:Meat Products / Q000032:analysis*; D008875:Middle Aged; D008903:Minerals / Q000494:pharmacology*; D010840:Phytosterols / Q000494:pharmacology*; D016037:Single-Blind Method
chemical_list: D008055:Lipids; D008903:Minerals; D010840:Phytosterols