title: A new key in breast cancer metastasis.
abstract: Unlocking the mysteries of cell metastasis, a major cause of cancer mortality, is essential in the development of novel therapies. In this issue of Cancer Cell, Li et al. (2004) identify a link between HER2 and CXCR4, two receptors previously implicated in breast cancer progression and metastasis. HER2 enhances the expression of CXCR4 by stimulating CXCR4 translation and attenuating CXCR4 degradation. Importantly, coexpression of HER2 and CXCR4 occurs in approximately 22% of human breast tumors and correlates with poor survival of breast cancer patients.
authors.affiliation: Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. benovic@mail.jci.tju.edu
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Benovic
authors.forename: Adriano
authors.initials: A
authors.lastname: Marchese
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D002448:Cell Adhesion; D002465:Cell Movement; D006801:Humans; D008954:Models, Biological; D009362:Neoplasm Metastasis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000378:metabolism*; D015996:Survival Rate; D015854:Up-Regulation
chemical_list: D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; D018719:Erb-b2 Receptor Tyrosine Kinases; D019718:Receptors, CXCR4