title: Angiogenic signal during cardiac repair.
abstract: Despite significant advances in myocardial revascularization and reperfusion, coronary artery disease and subsequently myocardial infarction, are the leading causes of morbidity and mortality in the United States. Strategies which improve the myocardial substrate during and following a myocardial infarction-such as the regrowth of functional blood vessels to the ischemic myocardium would be of great clinical importance. This review article attempts to address this important clinical issue through identifying potential signalling mechanisms by various mode of preconditioning that cause angiogenesis.
authors.affiliation: Molecular Cardiology Laboratory, Department of Surgery, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA. nmaulik@neuron.uchc.edu
authors.forename: Nilanjana
authors.initials: N
authors.lastname: Maulik
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D002470:Cell Survival; D004280:Dobutamine / Q000494:pharmacology; D006801:Humans; D000860:Hypoxia; D019157:Ischemic Preconditioning, Myocardial; D008954:Models, Biological; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy; D017202:Myocardial Ischemia; D009204:Myocardial Revascularization; D018919:Neovascularization, Physiologic; D017382:Reactive Oxygen Species; D013997:Time Factors; D014158:Transcription, Genetic; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D002316:Cardiotonic Agents; D017382:Reactive Oxygen Species; D042461:Vascular Endothelial Growth Factor A; D004280:Dobutamine