Bub1, a gatekeeper for Cdc20-dependent mitotic exit.
The mitotic spindle assembly checkpoint arrests cells at metaphase by suppressing Cdc20, a protein required to trigger ubiquitination and consequent degradation of cyclin B. New evidence from Tang et al. appearing in the November 5th issue of Molecular Cell finds that one of the checkpoint proteins, Bub1, specifically phosphorylates Cdc20 to suppress APC/C activation.
Margolis
Robert L
RL
Institut de Biologie Structurale J-P. Ebel, 41, rue Jules Horowitz, 38027 Grenoble Cedex 1, France.
D025601:Adenomatous Polyposis Coli Protein / Q000502:physiology; D000818:Animals; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000502:physiology*; D006801:Humans; D008938:Mitosis; D011494:Protein Kinases / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases
D025601:Adenomatous Polyposis Coli Protein; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; C577488:CDC20 protein, human; D011494:Protein Kinases; C584277:BUB1 protein, human; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases