[Oxidative stress in station service workers].
BACKGROUND
The aim of this study is to identify an oxidative stress in service station workers. Previous studies verified an increased incidence of leukemia and myeloma, however other authors haven't verified it. There are reports of nasal, pharyngeal, laryngeal, and lung cancer in service station workers. Our study wants to evaluate the oxidative balance in the fuel workers.


METHODS
We studied 44 subjects with gasoline exposure and 29 control subjects. We determined the blood concentrations of Glutathione reduced and oxidized, Protein sulfhydrylic (PSH) Vitamine E, Vitamine C, Malondialdehyde, Protein oxidized (OX-PROT) and beta carotene. The t test was performed to analyze the differences between the means, the Chi square was used to evaluate the statistical significance of associations between variable categorical (redox index). The Anova test excluded the confusing effect of age, smoke and alcohol habit.


RESULTS
The mean age of the workers was 36.6 years, instead the control group was 38. In the workers Glutathione reduced, Vit. E and Beta carotene were lower than in the control subjects, this difference was statistically significant (p < 0.01). The Malondialdehyde concentration was higher in the workers higher than in the control group, but this difference wasn't statistically significant.


CONCLUSIONS
Our data demonstrated Glutathione, Vit. E, and Beta carotene are useful to verify a reduction of the antioxidant activity. The only marker of the presence of oxidative injury that correlated to work exposure was the malondialdehyde. The redox index was surest marker. The limit of our study is the number of control group, it was little and lower than workers. Conclusively we believe it's useful to continue our studies and, if our results are going to be confirmed, we retain that stress oxidative determination would be verified in occupational medicine using these markers, especially to study exposure of the fuel workers who were investigated less and, in our opinion, would receive more attention.
Basso
A
A
DMIMP - Sez. Medicina del Lavoro, Università di Bari, Italy.
Elia
G
G
Petrozzi
M T
MT
Zefferino
R
R
D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking / Q000009:adverse effects; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D005742:Gasoline / Q000009:adverse effects*; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D016273:Occupational Exposure; D009790:Occupations; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012907:Smoking / Q000009:adverse effects; D011795:Surveys and Questionnaires; D014810:Vitamin E / Q000097:blood*; D019207:beta Carotene / Q000097:blood*
D005742:Gasoline; D019207:beta Carotene; D014810:Vitamin E; D008315:Malondialdehyde; D005978:Glutathione