Controlling stereochemistry during oxidative coupling. Preparation of Rp or Sp phosphoramidates from one P-chiral precursor.
Stereochemical outcome of oxidative coupling of H-phosphonate diesters with amines, promoted by iodine, can be controlled to obtain the corresponding phosphoramidate diesters with inversion or with retention of configuration at the phosphorus centre.
Nilsson
Johan
J
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
Stawinski
Jacek
J