title: Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.
abstract: The authors examined the association of the alcohol dehydrogenase 2 (ADH2) genotype with vascular events in community-dwelling Japanese (1,102 men/1,093 women). The allele ADH2*2 encodes an isozyme with a higher level of activity than ADH2*1. Here, the authors show that the ADH2*1 carriage is associated with high prevalence of cerebral infarction and lacunae in men. Multiple regression analyses confirmed that the risk of lacunae and cerebral infarction was increased by the ADH2*1 allele.
authors.affiliation: Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Fujisawa
authors.forename: F
authors.initials: F
authors.lastname: Ando
authors.forename: N
authors.initials: N
authors.lastname: Niino
authors.forename: I
authors.initials: I
authors.lastname: Ohsawa
authors.forename: H
authors.initials: H
authors.lastname: Shimokata
authors.forename: S
authors.initials: S
authors.lastname: Ohta
mesh_terms: D000328:Adult; D000368:Aged; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002544:Cerebral Infarction / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase