The role of neuropeptide processing enzymes in endocrine (prostate) cancer: EC 3.4.24.15 (EP24.15).
The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The "neural" prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.
Swanson
Todd A
TA
Midwest Proteome Center and the Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science/Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Kim
Sandra I
SI
Myers
Michael
M
Pabon
Amanda
A
Philibert
Keith D
KD
Wang
Mina
M
Glucksman
Marc J
MJ
D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009479:Neuropeptides / Q000096:biosynthesis / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D011499:Protein Processing, Post-Translational
D009479:Neuropeptides; D008666:Metalloendopeptidases; C022510:thimet oligopeptidase