title: The intracellular distribution and secretion of endopeptidases 24.15 (EC 3.4.24.15) and 24.16 (EC 3.4.24.16).
abstract: Endopeptidase 24.15 (EC 3.4.24.15; EP24.15) and endopeptidase 24.16 (EC 3.4.24.16; EP24.16) are enzymes involved in general peptide metabolism in mammalian cells and tissues. This review will focus on morphological and biochemical aspects related to the subcellular distribution and secretion of these homologous enzymes in the central nervous system. These are important issues for a better understanding of the functions of EP24.15 and EP24.16 within neuroendocrine systems.
authors.affiliation: Department of Cell Biology and Development, Av. Prof. Lineu Prestes 1524, Room 431, Sao Paulo, 05504-900, Brazil. eferro@usp.br
authors.forename: Emer S
authors.initials: ES
authors.lastname: Ferro
authors.forename: Flávia R
authors.initials: FR
authors.lastname: Carreno
authors.forename: Camila
authors.initials: C
authors.lastname: Goni
authors.forename: Paula A G
authors.initials: PA
authors.lastname: Garrido
authors.forename: Alessander O
authors.initials: AO
authors.lastname: Guimaraes
authors.forename: Leandro M
authors.initials: LM
authors.lastname: Castro
authors.forename: Vitor
authors.initials: V
authors.lastname: Oliveira
authors.forename: Maurício C
authors.initials: MC
authors.lastname: Araujo
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rioli
authors.forename: Marcelo D
authors.initials: MD
authors.lastname: Gomes
authors.forename: José Domingues
authors.initials: JD
authors.lastname: Fontenele-Neto
authors.forename: Stephen
authors.initials: S
authors.lastname: Hyslop
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism* / Q000648:ultrastructure; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D021381:Protein Transport
chemical_list: D008666:Metalloendopeptidases; C022510:thimet oligopeptidase; C062316:neurolysin