A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar.
A new phenylbutenoid dimer, (+/-)- trans-3-(4-hydroxy-3-methoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (+/-)- trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3-diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including 1D and 2D NMR experiments.
Han
Ah-Reum
AR
College of Pharmacy, Ewha Womans University, Seoul, Korea.
Min
Hye-Young
HY
Windono
Tri
T
Jeohn
Gwang-Ho
GH
Jang
Dae Sik
DS
Lee
Sang Kook
SK
Seo
Eun-Kyoung
EK
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D027343:Rhizome; D030521:Zingiberaceae
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts