Hereditary palmoplantar (epidermolytic) keratoderma: illustration through a familial report.
Hereditary palmoplantar keratoderma, a well-known clinical entity, is illustrated through a familial report of an unmarried young man who is the product of a consanguineous marriage (paternal and maternal grandmothers were sisters). The lesions were characterized by immense yellow waxy thickening of the skin surrounded by erythematous border (halo) and fissures/cracks associated with extensive scaling of the palms and soles. The lesions were bilateral and symmetrical. These features were supported by orthokeratotic hyperkeratosis hypergranulosis and acanthosis in hematoxylin-eosin stained tissue sections prepared from the soles. Mycelia/spores could not be identified on Periodic acid-Schiff (PAS) reaction. An autosomal dominant trait was revealed through family pedigree. An abridged update to recap the current status is highlighted.
Sehgal
Virendra N
VN
Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, Panchwati, Azadpur, Delhi, India. drsehgal@ndf.vsnl.net.in.
Sardana
Kabir
K
Sharma
Sonal
S
Raut
Dharmendra
D
D000287:Administration, Topical; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001707:Biopsy, Needle; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D007194:India / Q000453:epidemiology; D007645:Keratoderma, Palmoplantar / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D012873:Skin Diseases, Genetic / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology
D003879:Dermatologic Agents