title: gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish.
abstract: We have cloned and characterized the expression of zebrafish genetic screen homeobox 1 (gsh1). Early expression is confined to hindbrain rhombomeres; by mid-somitogenesis gsh1 is expressed in precise domains within the mesencephalon and diencephalon, as well as in intermediate spinal cord. Double-label experiments revealed that the diencephalic domain is coincident with hypothalamus and that spinal cord expression is in a region that generates interneurons. These data suggest gsh1 may play a role in patterning cell types generated in these domains.
authors.affiliation: Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403-1254, USA. sarahc@uoneuro.uoregon.edu
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Cheesman
authors.forename: Judith S
authors.initials: JS
authors.lastname: Eisen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D007031:Hypothalamus / Q000196:embryology* / Q000378:metabolism; D008969:Molecular Sequence Data; D013116:Spinal Cord / Q000196:embryology* / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology / Q000235:genetics* / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D018398:Homeodomain Proteins; D029961:Zebrafish Proteins; C500409:gsx1 protein, zebrafish