title: The pseudopapilledema of neonatal-onset multisystem inflammatory disease.
abstract: OBJECTIVE
  To report a rare case of neonatal-onset multisystem inflammatory disease with serial photographs to characterize the optic nerve findings.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A 6-year-old girl with neonatal-onset multisystem inflammatory disease, who had received systemic corticosteroid therapy for 5 years, had bilateral fibrillar opacities that surrounded the optic disks and extended into the peripapillary nerve fiber layer and vessels. A magnetic resonance imaging examination and lumbar puncture revealed elevated intracranial pressure.
  
  
  RESULTS
  The elevated intracranial pressure returned to normal following a corticosteroid taper. Optic disk photographs, taken 4 years earlier, were subsequently obtained. The optic disk appearance had remained unchanged over the 4-year period, consistent with a pseudopapilledema.
  
  
  CONCLUSIONS
  The optic disk appearance is not consistent with papilledema from increased intracranial pressure. The optic disk findings, in conjunction with the underlying inflammatory syndrome, suggest an infiltrative etiology for the atypical optic nerve findings in neonatal-onset multisystem inflammatory disease.
authors.affiliation: Department of Ophthalmology, The University of California, San Francisco, San Francisco, California, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Hollander
authors.forename: William F
authors.initials: WF
authors.lastname: Hoyt
authors.forename: Edward L
authors.initials: EL
authors.lastname: Howes
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Fredrick
mesh_terms: D017668:Age of Onset; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007249:Inflammation / Q000150:complications* / Q000188:drug therapy; D019586:Intracranial Hypertension / Q000139:chemically induced; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D010211:Papilledema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010781:Photography; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011239:Prednisolone; D008727:Methotrexate