Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1).
Ring-oxidized retinoids have been synthesized stereoselectively using the Stille cross-coupling reaction. Kinetic constants of mouse class I alcohol dehydrogenase (ADH1) with these retinoids were determined.
Domínguez
Marta
M
Departamento de Química Orgánica, Universidade de Vigo, 36200 Vigo, Spain. qolera@usc.es
Alvarez
Rosana
R
Martras
Sílvia
S
Farrés
Jaume
J
Parés
Xavier
X
de Lera
Angel R
AR
D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D001671:Biochemistry / Q000379:methods*; D004224:Diterpenes; D007700:Kinetics; D051379:Mice; D010084:Oxidation-Reduction; D012172:Retinaldehyde / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D012176:Retinoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014801:Vitamin A / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
C496908:4-hydroxy-retinol; D004224:Diterpenes; D012176:Retinoids; D014801:Vitamin A; C099660:4-oxoretinaldehyde; D000426:Alcohol Dehydrogenase; D012172:Retinaldehyde