Multiresidue method for the detection of tranquillisers, xylazine, and a beta-blocker in animal production by liquid chromatography-tandem mass spectrometry.
Tranquillisers are often used in animal production, especially in pigs to calm them before transport to the slaughterhouse. The use of certain substances (derived from phenothiazine) is totally prohibited, whilst other compounds (butyrophenone and beta-blockers) are regulated through the establishment of MRLs. A physico-chemical detection method based on liquid chromatography-tandem mass spectrometry is described. Validation was carried out according to the criteria laid down in Directive 2002/657/EC. The method was also used to detect and quantify these substances in treated animals.
Delahaut
Philippe
P
CER, Laboratoire d'Hormonologie, Rue du Point du Jour, 8 B-6900 Marloie, Belgium. delahaut@cer-dha.be
Brasseur
Pierre-Yves
PY
Dubois
Michel
M
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods*; D004350:Drug Residues / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D014149:Tranquilizing Agents / Q000032:analysis*; D014991:Xylazine / Q000032:analysis*
D000319:Adrenergic beta-Antagonists; D014149:Tranquilizing Agents; D014991:Xylazine