Association between LDL particle size and postprandial increase of remnant-like particles in Japanese type 2 diabetic patients.
Small, dense LDL, as well as chylomicron- and VLDL-remnant lipoproteins, are known to be important risk factors for coronary heart disease in patients with type 2 diabetes mellitus. The aim of this study was to clarify the relationship between LDL particle size and postprandial remnant lipoprotein levels in Japanese type 2 diabetic patients. Forty-six patients with type 2 diabetes mellitus were divided into tertiles according to LDL particle size. The peak LDL particle diameter was <26.30 nm in tertile 1, 26.30-26.85 nm in tertile 2, and >26.85 nm in tertile 3. After a test meal, tertile 1 had a significantly greater increment of triglycerides (TG), remnant-like particle (RLP)-TG, and RLP-cholesterol (RLP-C) than tertiles 2 and 3. There was a negative correlation between LDL particle size and the postprandial increases of TG, RLP-TG, and RLP-C. These results indicate that smaller sized LDL particles may be a marker of fasting state for an exaggerated postprandial increase of remnant lipoproteins as well as an increase of TG-rich lipoproteins.
Takayanagi
Naoko
N
Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Onuma
Tomio
T
Kato
Shinobu
S
Nishiyama
Kyoko
K
Nomiyama
Takashi
T
Kawamori
Ryuzo
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000208:ethnology*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D008077:Lipoproteins, LDL; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002784:Cholesterol