False-positive Aspergillus galactomannan enzyme-linked immunosorbent assay results in vivo during amoxicillin-clavulanic acid treatment.
Positive Platelia Aspergillus test results were observed in consecutive serum samples from an immunocompromised host during amoxicillin-clavulanic acid treatment, and a correlation between plasmatic amoxicillin concentration and galactomannan optical density index was observed. Amoxicillin-clavulanic acid vials tested positive for galactomannan but were negative for Aspergillus DNA.
Mattei
Daniele
D
Department of Hematology, Santa Croce Hospital, Via Michele Coppino 26, 12100 Cuneo, Italy. daealemattei@tin.it
Rapezzi
Davide
D
Mordini
Nicola
N
Cuda
Federica
F
Lo Nigro
Cristiana
C
Musso
Maura
M
Arnelli
Aldo
A
Cagnassi
Sebastiano
S
Gallamini
Andrea
A
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy*; D001230:Aspergillus / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D016867:Immunocompromised Host; D008351:Mannans / Q000032:analysis*; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic
D008351:Mannans; D011933:Reagent Kits, Diagnostic; C012990:galactomannan; D019980:Amoxicillin-Potassium Clavulanate Combination; D005690:Galactose