Severe sialadenitis: a new complication of drug reaction with eosinophilia and systemic symptoms.
BACKGROUND
Drug cutaneous reaction and isolated cases of parotitis induced by terbinafine have been reported.


METHODS
We report a case of drug reaction with eosinophilia and systemic symptoms induced by terbinafine associated with a severe sialadenitis and a complete sicca syndrome. Evolution was protracted with a slow recovery of the rash but sicca syndrome persisted with only a very mild improvement at 6 months.


CONCLUSIONS
Liver, kidneys, lungs, and heart are the organs the most frequently involved in drug reaction with eosinophilia and systemic symptoms. Salivary and lacrimal glands can also be severely involved in the course of drug reaction with eosinophilia and systemic symptoms.
Abecassis
Sophia
S
Departments of Dermatology, Hôpital Henri Mondor, Créteil, France.
Roujeau
Jean-Claude
JC
Bocquet
Hélène
H
Copie-Bergman
Christiane
C
Radier
Catherine
C
Revuz
Jean
J
Cosnes
Anne
A
D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009281:Naphthalenes / Q000009:adverse effects*; D012793:Sialadenitis / Q000139:chemically induced*; D012859:Sjogren's Syndrome / Q000139:chemically induced*; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine