Tocopherol long chain fatty alcohols decrease the production of TNF-alpha and NO radicals by activated microglial cells.
The synthesis of a series of Tocopherol long chain Fatty Alcohols (TFA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TFA bearing 12 carbon atoms on the side chain (n=12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia.
Muller
Thierry
T
Laboratoire de chimie organique des substances naturelles, Centre de Neurochimie, UMR 7123 CNRS, Université Louis Pasteur, 67084 Strasbourg, France.
Grandbarbe
Luc
L
Morga
Eleonora
E
Heuschling
Paul
P
Luu
Bang
B
D000818:Animals; D002460:Cell Line; D005233:Fatty Alcohols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000378:metabolism; D051379:Mice; D017628:Microglia / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D024502:alpha-Tocopherol / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D005233:Fatty Alcohols; D005609:Free Radicals; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D024502:alpha-Tocopherol