Influence of smoking on serum and milk of mothers, and their infants' serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels.
OBJECTIVE
To investigate the serum and milk in active-smoking and nonsmoking mothers, and their infants' insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels.


METHODS
A cohort study conducted at a tertiary medical center.


METHODS
Forty-four mothers (age range: 21-34 years) and their newborns (7 days old) were enrolled in the study. Mothers were interviewed and classified according to their smoking status into one of two groups: the active-smoking mothers (n = 21) and the nonsmoking mothers (n = 23).


RESULTS
There was no difference noted in either IGF-I, IGFBP-3 or IGF-I/IGFBP-3 ratios in serum and milk of mothers, and their infants' serum samples according to maternal smoking.


CONCLUSIONS
This study demonstrated that maternal smoking (5-10 cigarettes/day) did not influence the maternal and infant serum levels of IGF-I and IGFBP-3 as well as the breast milk levels of these peptides.
Ermis
Bahri
B
Division of Neonatology, Department of Pediatrics, School of Medicine, Zonguldak Karaelmas University, Kozlu, Zonguldak, Turkey. bahriermis@yahoo.com
Altinkaynak
Konca
K
Yildirim
Abdulkadir
A
Ozkan
Behzat
B
D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008895:Milk, Human / Q000378:metabolism*; D011247:Pregnancy; D012907:Smoking / Q000503:physiopathology*
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I