title: Autoimmune etiology of complex regional pain syndrome (M. Sudeck).
abstract: Sera of 12 patients with complex regional pain syndrome (CRPS) were tested for the occurrence of autoantibodies against nervous system structures. Immunohistochemistry revealed autoantibodies against autonomic nervous system structures in 5 of 12 (41.6%) of the patients. Western blot analysis showed neuronal reactivity in 11 of 12 (91.6%) patients. The authors hypothesize that CRPS can result from an autoimmune process against the sympathetic nervous system.
authors.affiliation: Department of Neurology, Justus-Liebig-University, Am Steg 14, 35385 Giessen, Germany. franz.blaes@neuro.med.uni-giessen.de
authors.forename: F
authors.initials: F
authors.lastname: Blaes
authors.forename: K
authors.initials: K
authors.lastname: Schmitz
authors.forename: M
authors.initials: M
authors.lastname: Tschernatsch
authors.forename: M
authors.initials: M
authors.lastname: Kaps
authors.forename: I
authors.initials: I
authors.lastname: Krasenbrink
authors.forename: G
authors.initials: G
authors.lastname: Hempelmann
authors.forename: M E
authors.initials: ME
authors.lastname: Bräu
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002460:Cell Line; D020918:Complex Regional Pain Syndromes / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D005728:Ganglia, Sympathetic / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009197:Myenteric Plexus / Q000276:immunology; D009474:Neurons / Q000276:immunology; D013564:Sympathetic Nervous System / Q000276:immunology*
chemical_list: D001323:Autoantibodies