title: Locally induced hypothermia for treatment of acute ischaemic stroke: a physical feasibility study.
abstract: During the treatment of stroke by local intra-arterial thrombolysis (LIT) it is frequently possible to pass the blood clot with a micro-catheter, allowing perfusion of brain tissue distally to the occlusion. This possibility allows for new early treatments of ischaemic brain tissue, even before the blood clot has been removed. One potential new approach to preserve brain tissue at risk may be locally induced endovascular hypothermia. Physical parameters such as the required micro-catheter input pressure, output velocity and flow rates, and a heat exchange model, applicable in the case of a micro-catheter placed within a guiding catheter, are presented. Also, a simple cerebral temperature model is derived that models the temperature response of the brain to the perfusion with coolant fluids. Based on this model, an expression has been derived for the time needed to reach a certain cerebral target temperature. Experimental in vitro measurements are presented that confirm the usability of standard commercially available micro-catheters to induce local hypothermia of the brain. If applied in vivo, the model predicts a local cooling rate of ischaemic brain tissue of 300 g of approximately 1 degrees C in 1 min, which is up to a factor 30-times faster than the time-consuming systemic hypothermia via the skin. Systemic body temperature is only minimally affected by application of local hypothermia, thus avoiding many limitations and complications known in systemic hypothermia.
authors.affiliation: Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Inselspital, 3010, Berne, Switzerland. johannes.slotboom@insel.ch
authors.forename: J
authors.initials: J
authors.lastname: Slotboom
authors.forename: C
authors.initials: C
authors.lastname: Kiefer
authors.forename: C
authors.initials: C
authors.lastname: Brekenfeld
authors.forename: C
authors.initials: C
authors.lastname: Ozdoba
authors.forename: L
authors.initials: L
authors.lastname: Remonda
authors.forename: K
authors.initials: K
authors.lastname: Nedeltchev
authors.forename: M
authors.initials: M
authors.lastname: Arnold
authors.forename: H
authors.initials: H
authors.lastname: Mattle
authors.forename: G
authors.initials: G
authors.lastname: Schroth
mesh_terms: D000465:Algorithms; D002545:Brain Ischemia / Q000150:complications / Q000628:therapy*; D002404:Catheterization; D005240:Feasibility Studies; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D008959:Models, Neurological; D020521:Stroke / Q000209:etiology / Q000628:therapy*; D022722:Thermogenesis / Q000502:physiology