title: Bystander effects, adaptive response and genomic instability induced by prenatal irradiation.
abstract: The developing human embryo and fetus undergo very radiosensitive stages during the prenatal development. It is likely that the induction of low dose related effects such as bystander effects, the adaptive response, and genomic instability would have profound effects on embryonic and fetal development. In this paper, I review what has been reported on the induction of these three phenomena in exposed embryos and fetuses. All three phenomena have been shown to occur in murine embryonic or fetal cells and structures, although the induction of an adaptive response (and also likely the induction of bystander effects) are limited in terms of when during development they can be induced and the dose or dose-rate used to treat animals in utero. In contrast, genomic instability can be induced throughout development, and the effects of radiation exposure on genome instability can be observed for long times after irradiation including through pre- and postnatal development and into the next generation of mice. There are clearly strain-specific differences in the induction of these phenomena and all three can lead to long-term detrimental effects. This is true for the adaptive response as well. While induction of an adaptive response can make fetuses more resistant to some gross developmental defects induced by a subsequent high dose challenge with ionizing radiation, the long-term effects of this low dose exposure are detrimental. The negative effects of all three phenomena reflect the complexity of fetal development, a process where even small changes in the timing of gene expression or suppression can have dramatic effects on the pattern of biological events and the subsequent development of the mammalian organism.
authors.affiliation: Institute for Science and Ethics, University Duisburg-Essen, Auf dem Sutan 12, D-45239 Essen, Germany. christian.streffer@uni-essen.de
authors.forename: Christian
authors.initials: C
authors.lastname: Streffer
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D024201:Bystander Effect; D043171:Chromosomal Instability; D005260:Female; D047109:Fetal Development / Q000528:radiation effects; D008297:Male; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D051381:Rats