title: Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome.
abstract: We report a case of Waldenstrom's macroglobulinemia (WM) presenting as classic Goodpasture's syndrome. Thrombocytopenia, an additional autoimmune phenomenon, further complicated the clinical course. Renal disease is well recognized in Waldenstrom's macroglobulinemia and other B-cell dyscrasias. Similarly, a wide spectrum of autoimmune-mediated conditions has been reported in association with paraproteinemia. However, rapidly progressive glomerulonephritis in association with antiglomerular basement membrane antibodies has never been reported as either an autoimmune or a renal manifestation of WM. This article reviews the current understanding of renal pathology and autoimmune phenomenon associated with WM.
authors.affiliation: Renal Section, Division of Medicine, Imperial College, Hammersmith Hospital, London, UK.
authors.forename: Sonia
authors.initials: S
authors.lastname: Gandhi
authors.forename: Mark A
authors.initials: MA
authors.lastname: Little
authors.forename: Ken
authors.initials: K
authors.lastname: Farrington
mesh_terms: D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D051437:Renal Insufficiency / Q000276:immunology; D013921:Thrombocytopenia / Q000276:immunology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000175:diagnosis* / Q000276:immunology