title: [Development of software for data analysis by therapeutic drug monitoring of teicoplanin, a glycopeptide antibiotic].
abstract: We developed a new software named TEICTDM based on the Bayesian estimation utilized in the therapeutic drug monitoring (TDM) of teicoplanin, a glycopeptide antibiotic, for the estimation of individual pharmacokinetic parameters. Therefore, it is necessary to input more than one plasma concentration(s) determined in individual patient. Individual pharmacokinetic parameters were calculated by a least squares methods, MULTI2 (BAYES). Two-compartment model was applied to determine individual pharmacokinetic parameters in male healthy volunteers in Japan, and the relationship between clearance of teicoplanin and creatinine clearance in adult patients with various degrees of renal impairment in Europe was used. A series of work from data input to graph drawing or printing of results could efficiently carried out with the best of use of this software, suggesting that this software is now available in clinical practice.
authors.affiliation: Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd., 3-4-7, Doshomachi, Chuo-ku, Osaka 541-8514, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Niwa
authors.forename: Yoji
authors.initials: Y
authors.lastname: Tokuma
authors.forename: Takao
authors.initials: T
authors.lastname: Ito
authors.forename: Jiro
authors.initials: J
authors.lastname: Kimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Tabata
authors.forename: Akira
authors.initials: A
authors.lastname: Takagi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001499:Bayes Theorem; D003404:Creatinine; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D012985:Software Design; D013223:Statistics as Topic / Q000379:methods*; D017334:Teicoplanin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D003404:Creatinine