title: [Interest of PET/CT scan fusion to assess mandible involvement in oral cavity and oro pharyngeal carcinomas].
abstract: The aim of the study is to assess mandible involvement in oral cavity and oropharyngeal carcinomas.
  
  
  OBJECTIVE
  To evaluate interest of fusion of Positron Emission Tomography (PET) with Computed Tomography scan (CT scan).
  
  
  METHODS
  Eight patients were included in this prospective study. Each patient underwent PET and CT scan of the head and neck before surgery including tumorectomy and mandibulectomy. We compared results of PET- CT fusion with histologic examinations.
  
  
  RESULTS
  Oral cavity (6), oropharyngeal (2) carcinoma: Mandibular invasion was suspected by PET-CT in 3 cases, but was confirmed in histological examination in only 2 cases. In 5 cases, PET-CT did not find mandibular invasion; this was confirmed in histological examination in all cases. Sensibility of PET-CT fusion was 100%, specificity was 83%. Positive predictive value was 66% and negative predictive value was 100%.
  
  
  CONCLUSIONS
  PET-CT fusion provided maximal sensitivity. Specificity was better than for MRI but less than CT-scan. There were no false negatives and the false positive rate was 33%.
  
  
  CONCLUSIONS
  PET-CT fusion is interesting to predict mandible involvement. Further studies are necessary to confirm these preliminary results.
authors.affiliation: Service ORL et de Chirurgie Cervico-Faciale, CHU, Avenue de la côte de nacre, 14033 Caen Cedex.
authors.forename: E
authors.initials: E
authors.lastname: Babin
authors.forename: M
authors.initials: M
authors.lastname: Hamon
authors.forename: H
authors.initials: H
authors.lastname: Bénateau
authors.forename: C
authors.initials: C
authors.lastname: Desmonts
authors.forename: F
authors.initials: F
authors.lastname: Comoz
authors.forename: M
authors.initials: M
authors.lastname: Goullet de Rugy
authors.forename: A
authors.initials: A
authors.lastname: Béquignon
authors.forename: E
authors.initials: E
authors.lastname: Chesnay
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000098:blood supply* / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009055:Mouth / Q000098:blood supply* / Q000000981:diagnostic imaging*; D009959:Oropharyngeal Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18