title: [Clinical study on respiratory mechanics of synchronized intermittent mandatory ventilation in premature infants with respiratory failure].
abstract: OBJECTIVE
  To evaluate the clinical significance of synchronized intermittent mandatory ventilation (SIMV) in prematures infants necessitating assistant ventilation.
  
  
  METHODS
  Forty-two premature infants were studied in whom SIMV was used in 24 and intermittent mandatory ventilation (IMV) was used in 18. The parameters of fractional concentration of inspired oxygen (FiO(2)), peak inspiratory pressure (PIP), expiratory tidal volume (V(Texp)), oxygen index (OI), compliance of the respiratory system (Crs) and airway resistance (Raw) were compared. The frequency of administration of sedatives and incidence rate of complications were also compared between two groups.
  
  
  RESULTS
  In SIMV group, PIP, V(Texp), Raw and Crs were significant better after 2 hours ventilation (all P<0.05). There were significant difference in FiO(2) after 12 hours and OI at 24 hours in two groups. They were better in SIMV group. Sedatives were less used in SIMV group than IMV group (P<0.05).
  
  
  CONCLUSIONS
  In premature infants, SIMV could reduce FiO(2), PIP, OI, Raw and improve V(Texp), Crs more rapidly when assistant ventilation is necessary. The sedatives are used less in patients on SIMV.
authors.affiliation: NICU, Futian Women and Children Health Institute, Shenzhen 518045, Guangdong, China.
authors.forename: Shao-hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Shao-bo
authors.initials: SB
authors.lastname: Chen
authors.forename: Feng-wu
authors.initials: FW
authors.lastname: Kuang
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods*; D012131:Respiratory Insufficiency / Q000628:therapy*; D015656:Respiratory Mechanics