Microalbuminuria in adults after prenatal exposure to the Dutch famine.
Maternal undernutrition during gestation is associated with an increase in cardiovascular risk factors in the offspring in adult life. The effect of famine exposure during different stages of gestation on adult microalbuminuria (MA) was studied. MA was measured in 724 people, aged 48 to 53, who were born as term singletons in a university hospital in Amsterdam, the Netherlands, around the time of the Dutch famine 1944 to 1945. Twelve percent of people who were exposed to famine in mid gestation had MA (defined as albumin/creatinine ratio >/=2.5) compared with 7% of those who were not prenatally exposed to famine (odds ratio 2.1; 95% confidence interval 1.0 to 4.3). Correcting for BP, diabetes, and other influences that affect MA did not attenuate this association (adjusted odds ratio 3.2; 95% confidence interval 1.4 to 7.7). The effect of famine was independent of size at birth. Midgestation is a period of rapid increase in nephron number, which is critical in determining nephron endowment at birth. Fetal undernutrition may lead to lower nephron endowment with consequent MA in adult life.
Painter
Rebecca C
RC
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center at the University of Amsterdam, The Netherlands. r.c.painter@amc.uva.nl
Roseboom
Tessa J
TJ
van Montfrans
Gert A
GA
Bossuyt
Patrick M M
PM
Krediet
Raymond T
RT
Osmond
Clive
C
Barker
David J P
DJ
Bleker
Otto P
OP
D000419:Albuminuria / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D048070:Fetal Nutrition Disorders / Q000150:complications / Q000453:epidemiology*; D018149:Glucose Intolerance / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000002:abnormalities; D008875:Middle Aged; D009399:Nephrons / Q000002:abnormalities; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D013217:Starvation