Phosphatidylinositol transfer proteins: emerging roles in cell proliferation, cell death and survival.
The actual cellular functions of the highly homologous small isoforms of the phosphatidylinositol transfer proteins, PI-TPalpha and PI-TPbeta have been studied using many different experimental conditions varying from in vitro experiments with purified proteins and lipid vesicles to investigations in animals. In this review, the very diverse data of these investigations have been collected and joined to propose a model for the cellular functions of PI-TPalpha and PI-TPbeta. The model is based on the suggested roles of PI-TPalpha and PI-TPbeta in various lipid-mediated cellular signaling pathways and leads to the conclusion that both proteins have a regulating function in pathways involved in the proliferation, apoptosis as well as survival of cells.
Snoek
Gerry T
GT
Center for Biomembranes and Lipid Enzymology, Department Biochemistry of Lipids, Utrecht University, The Netherlands. g.t.snoek@chem.uu.nl
D000818:Animals; D016923:Cell Death; D049109:Cell Proliferation; D002470:Cell Survival; D018922:HL-60 Cells; D006801:Humans; D050356:Lipid Metabolism; D008954:Models, Biological; D008958:Models, Molecular; D010716:Phosphatidylinositols / Q000378:metabolism*; D049294:Phospholipid Transfer Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D010716:Phosphatidylinositols; D049294:Phospholipid Transfer Proteins