Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.
A novel anti-hepatitis C virus (HCV) agent, N(3),5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine.
Wang
Peiyuan
P
Pharmasset Inc., Tucker, Georgia 30084, Utah State University, Logan, Utah 84322, USA. pwang@pharmasset.com
Hollecker
Laurent
L
Pankiewicz
Krzysztof W
KW
Patterson
Steven E
SE
Whitaker
Tony
T
McBrayer
Tamara R
TR
Tharnish
Phillip M
PM
Sidwell
Robert W
RW
Stuyver
Lieven J
LJ
Otto
Michael J
MJ
Schinazi
Raymond F
RF
Watanabe
Kyoichi A
KA
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012367:RNA, Viral / Q000037:antagonists & inhibitors; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors
D000998:Antiviral Agents; C494561:N3,5'-cyclo-4-ribofuranosyl-vic-triazolo(4,5-b)pyridin-5-one; D009705:Nucleosides; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase