title: Therapeutic efficiency of continuous renal replacement therapy--experience of a single Romanian center.
abstract: We have studied 24 patients with acute renal failure (ARF) or acutization of chronic renal failure (CRF) caused by a variety of different disorders. A rapid decline in renal excretory function, fluid, electrolyte, and divalent ion disturbances determined us to initiate continuous renal replacement: continuous venovenous hemofiltration (CVVHF)--28 procedures in 15 patients and continuous venovenous hemodiafiltration (CVVHDF)--11 procedures in 11 patients. Mean duration of CVVHF was 21.6+/-6.9 h, with a mean blood flow rate of 116.9+/-16.4 ml/min and an ultrafiltration rate of 6.4+/-4.6 ml/min. Serum creatinine level decreased from 12.6 to 8.3 mg% and the concentration of urea from 237 to 166 mg%. Mean duration of hemodiafiltration was 24+/-8.5 h, with mean blood flow rate of 134+/-15.2 ml/min, mean dialysate flow of 35+/-7 ml/min and mean ultrafiltration rate of 5.6+/-2.1 ml/min. Serum creatinine level decreased from 11.6 to 6.36 mg% and the concentration of urea from 236 to 137 mg%. Survival rate was 79.2% (19/24 patients). Complete recover of renal function was achieved in 5 patients, partial recover in 5 patients and 9 patients were included in chronic dialysis. In 8/24 (30%) patients we encountered complications, such as hypotension in 2 cases, bleeding disorders in 5 cases or diselectrolithemias in 2 cases. As a consequence, continuous renal replacement therapy is efficient, having an acceptable rate of adverse effects in patients with ARF or acutization of CRF.
authors.affiliation: Department of Internal Medicine-Nephrology, Fundeni Institute, Bucharest, Romania. mih@xnet.ro
authors.forename: M
authors.initials: M
authors.lastname: Voiculescu
authors.forename: Camelia
authors.initials: C
authors.lastname: Ionescu
authors.forename: G
authors.initials: G
authors.lastname: Ismail
authors.forename: Mihaela
authors.initials: M
authors.lastname: Roşu
authors.forename: A
authors.initials: A
authors.lastname: Szigeti
authors.forename: Olguţa
authors.initials: O
authors.lastname: Iliescu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D002404:Catheterization / Q000379:methods; D006801:Humans; D008875:Middle Aged; D051437:Renal Insufficiency / Q000628:therapy*; D017582:Renal Replacement Therapy / Q000009:adverse effects; D012383:Romania; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants