Making the right choice--long-range chromosomal interactions in development.
Schizosaccharomyces pombe has the remarkable potential to switch mating type as often as every generation, through selective interaction of an expressor locus with either of two transcriptionally silent donor loci. Recent results demonstrate that selection of the appropriate donor locus likely occurs through mating-type and heterochromatin-dependent spreading of a protein complex that marks the correct donor locus.
Broach
James R
JR
Department of Molecular Biology, Princeton University, Princeton, NJ 08558, USA. jbroach@molbio.princeton.edu
D002875:Chromosomes / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal / Q000235:genetics; D005800:Genes, Fungal; D049770:Genes, Mating Type, Fungal; D005812:Genes, Switch / Q000235:genetics*; D011995:Recombination, Genetic / Q000235:genetics; D012100:Reproduction, Asexual / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development; D012568:Schizosaccharomyces / Q000235:genetics* / Q000254:growth & development
D004268:DNA-Binding Proteins