title: Steroids from the roots of Cynanchum stauntonii.
abstract: A chemical investigation of the roots of Cynanchum stauntonii has resulted in the characterization of a new hydroperoxide with a 13,14 : 14,15-disecopregnane-type skeleton, named stauntonine (1), together with three related compounds, anhydrohirundigenin (2), anhydrohirundigenin monothevetoside (3), and glaucogenin-C mono- D-thevetoside (4). Their structures were established by spectroscopic methods, including X-ray crystallographic diffraction analysis of stauntonine that confirmed its relative stereochemistry. The compound 1 showed dose-dependent relaxation on aortic rings with endothelium contracted by phenylepherine or KCl.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing , P.R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Qin
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Li
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects*; D018360:Crystallography, X-Ray; D031105:Cynanchum; D004730:Endothelium, Vascular / Q000187:drug effects*; D010656:Phenylephrine; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D011189:Potassium Chloride; D051381:Rats; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts; D014665:Vasodilator Agents; D010656:Phenylephrine; D011189:Potassium Chloride