Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization.
Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. The authors present a case of spontaneous splenic rupture, without splenomegaly, in a parental donor undergoing PBPC mobilization, review the literature regarding this adverse event, and explore issues regarding donor safety.
Dincer
Ayse P
AP
Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. adincer@mcw.edu
Gottschall
Jerome
J
Margolis
David A
DA
D000328:Adult; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010290:Parents; D036102:Peripheral Blood Stem Cell Transplantation; D013154:Spleen / Q000098:blood supply / Q000473:pathology; D013161:Splenic Rupture / Q000209:etiology*; D014019:Tissue Donors
D016179:Granulocyte Colony-Stimulating Factor