title: A concise synthesis of spirotryprostatin A.
abstract: The preparation of two new synthons, 2,5- and 2,6-dibromotryptophan esters, and their use in diastereoselective intramolecular N-acyliminium ion spirocyclization methodology for the rapid construction of spirotryprostatin A and analogues are described.
authors.affiliation: Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Fumiko Y
authors.initials: FY
authors.lastname: Miyake
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yakushijin
authors.forename: David A
authors.initials: DA
authors.lastname: Horne
mesh_terms: D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010879:Piperazines; D013141:Spiro Compounds; C478300:spirotryprostatin A