[The concentrations of homocysteine, folic acid and vitamin B12 in alcohol dependent male patients].
Metabolism of homocysteine (sulphur-containing amino acid) is accomplished in the remethylation cycle where vitamin B12 and folic acid are essential coenzymes. Markedly elevated homocysteine concentrations have been observed in patients with nutritional deficiencies of vitamin B12 and folate. Hyperhomocysteinemia in alcohol abusers may result from malnutrition and disorder of intestine absorption.


OBJECTIVE
The aim of the study was the estimation of homocysteine, folic acid and vitamin B12 concentrations in alcohol dependent male patients.


METHODS
71 males with a clinical diagnosis of alcohol dependence (ICD-10) have been examined. The investigated parameters have been determined in the blood serum, the homocysteine by means of immunochemical method, vitamin B12 and folic acid by means of immunoenzymatic assay.


RESULTS
Serum homocysteine concentration was significantly higher and serum folic acid concentration was lower in alcohol dependent men than in controls. Mean concentrations of folic acid and vitamin B12 were significantly lower in patients with hyperhomocysteinemia than in men with normal homocysteine concentration. The highest correlation was indeed noticed between folate deficiency and the intensity of hyperhomocysteinemia.


CONCLUSIONS
The development of hyperhomocysteinemia is associated with alcohol dependence that is also a probable cause of folate and vitamin B12 deficiency.
Kopczyńska
Ewa
E
Katedry i Zakładu Patobiochemii i Chemii Klinicznej AM w Bydgoszczy.
Ziółkowski
Marcin
M
Jendryczka-Maćkiewicz
Ewa
E
Odrowaz-Sypniewska
Grazyna
G
Opozda
Krzysztof
K
Tyrakowski
Tomasz
T
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000150:complications; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005492:Folic Acid / Q000097:blood*; D005494:Folic Acid Deficiency / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014805:Vitamin B 12 / Q000097:blood*; D014806:Vitamin B 12 Deficiency / Q000097:blood
D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12