title: Novel sesterterpenes from Leucosceptrum canum of nepalese origin.
abstract: Two novel sesterterpenoids, leucosesterterpenone (1) and leucosesterlactone (2), with novel skeleta were isolated from the hexane extract of the medicinal plant, Leucosceptrum canum. Their structures were established by the analysis of NMR data and the single-crystal X-ray diffraction of compound 1. Compounds 1 and 2 were found to exhibit activity against prolylendopeptidase (PEP).
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Rosa
authors.initials: R
authors.lastname: Ranjit
authors.lastname: Atta-ur-Rahman
authors.forename: Sajjad
authors.initials: S
authors.lastname: Hussain
authors.forename: Krishna Prasad
authors.initials: KP
authors.lastname: Devkota
authors.forename: Tirtha Maiya
authors.initials: TM
authors.lastname: Shrestha
authors.forename: Masood
authors.initials: M
authors.lastname: Parvez
mesh_terms: D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D054830:Sesterterpenes; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D054830:Sesterterpenes; D013729:Terpenes