HDAC4: a corepressor controlling bone development.
RUNX2 is a transcription factor with a well-characterized role in bone development. In this issue of Cell, Vega and colleagues (Vega et al., 2004) show that HDAC4 interacts with RUNX2 and impacts upon chondrocyte hypertrophy and bone formation.
Hug
Bruce A
BA
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
D000818:Animals; D001846:Bone Development; D019902:Chondrocytes / Q000502:physiology*; D050659:Core Binding Factor Alpha 1 Subunit; D006655:Histone Deacetylases / Q000235:genetics / Q000502:physiology*; D006984:Hypertrophy; D051379:Mice; D009154:Mutation; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology; D010012:Osteogenesis; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology; D014162:Transfection
D050659:Core Binding Factor Alpha 1 Subunit; D009363:Neoplasm Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C400300:HDAC4 protein, human; D006655:Histone Deacetylases