Different effects of L-type and L+N-type calcium channel blockers on hamster cheek pouch venules.
Dihydropyridine calcium channel blockers are not uniform in terms of their action on calcium channel. L-type calcium channel blockers dilate the resistance arterioles. Cilnidipine is a dihydropyridine calcium channel blocker that also acts on N-type calcium channels, and may dilate venules through its effect on the sympathetic receptor. The influence of an L-type calcium channel blocker (nifedipine) or this L+N type blocker at 10(-7) mol to 10(-4) mol on venular diameter was examined by superfusion of male Syrian hamster cheek pouches. Nifedipine dose dependently dilated the arterioles alone, whereas cilnidipine dilated both arterioles and venules. Application of 10(-7) mol omega conotoxin, an inhibitor of N-type channels, after nifedipine led to significant dilation of venules, while it had no influence when administered after cilnidipine. These findings indicate that the effects of calcium channel blockers on the venules differ according to the action on N-type calcium channels, and that cilnidipine (an L+N type calcium channel blocker) dilates venules through its additional action on N-type channels.
Kushiro
Toshio
T
Department of Cardiology, Nihon University Surugadai Hospital, Tokyo, Japan. kushiro@med.nihon-u.ac.jp
Watanabe
Nagaoki
N
Takahashi
Atsuhiko
A
Koike
Miyuki
M
Saito
Fumio
F
Otsuka
Yuji
Y
Kanmatsuse
Katsuo
K
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000187:drug effects*; D020864:Calcium Channels, N-Type / Q000187:drug effects*; D006224:Cricetinae; D004095:Dihydropyridines / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000098:blood supply* / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D014699:Venules / Q000187:drug effects; D020960:omega-Conotoxins / Q000494:pharmacology
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D020864:Calcium Channels, N-Type; D004095:Dihydropyridines; D020960:omega-Conotoxins; C065927:cilnidipine; D009543:Nifedipine