title: Transmission disequilibrium analysis of the GSN gene in a cohort of family trios with schizophrenia.
abstract: Apoptosis is thought to play a role in neuronal pathology in schizophrenia. Recently, the GSN gene was reported to have anti-apoptotic properties. In a genome-wide expression analysis on schizophrenia, GSN was also found to be significantly down-regulated in schizophrenia. All the hints suggest that GSN is a novel candidate gene in occurrence of schizophrenia. In this work, we genotyped 3 SNPs around the GSN locus in 493 sets of the Han Chinese trio sample using allele-specific PCR. A weak association or a marginally positive result was detected (0.05 for P-value of the overtransmitted haplotype and 0.02 for a global P-value).
authors.affiliation: Bio-X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, 1954 Huashan Road, Shanghai 200030, PR China.
authors.forename: Z R
authors.initials: ZR
authors.lastname: Xi
authors.forename: W
authors.initials: W
authors.lastname: Qin
authors.forename: Y F
authors.initials: YF
authors.lastname: Yang
authors.forename: G
authors.initials: G
authors.lastname: He
authors.forename: S H
authors.initials: SH
authors.lastname: Gao
authors.forename: M S
authors.initials: MS
authors.lastname: Ren
authors.forename: Y W
authors.initials: YW
authors.lastname: Peng
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D018260:Gelsolin / Q000235:genetics*; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology
chemical_list: D018260:Gelsolin