[The significance of HLA-G for miscarriages].
In the article, we described major histocompatibility antigens and their distribution in the feto-maternal junction. In particular we have taken into consideration HLA-G, its structure and isoforms. Further on, we cited opinions about their role during reproductive processes, creation of syncytiotrophoblast, remodeling of spiral arteries, growing and maturation of placenta. The lack of correct function of HLA-G can lead to disorders in ovum implantation, hormonal and nutritional function of placenta which can cause reproductive failure, including abortions, intrautrine growth retardation, intrauterine fetal demise, preeclampsia. The genotype HLA-G is potentially related to habitual abortions.
Grzywacz
Maciej
M
Szpital Wojewódzki w Zielonej Górze.
Ronin-Walknowska
Elzbieta
E
D000022:Abortion, Spontaneous / Q000276:immunology*; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000276:immunology
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I