Palladium-catalyzed borylation of phenyl bromides and application in one-pot Suzuki-Miyaura biphenyl synthesis.
The coupling reaction of pinacolborane with various aryl bromides in the presence of a catalytic amount of Pd(OAc)(2) together with DPEphos as ligand and Et(3)N as base provided arylboronates. High yields were obtained in the case of electron-donor substituted aryl bromides. The direct preparation of arylboronates allowed the one-pot, two-step synthesis of unsymmetrical biaryls in high yields. [reaction: see text]
Broutin
Pierre-Emmanuel
PE
Laboratoire de Stéréochimie associé au CNRS (UMR 7008), Université Louis Pasteur (ECPM), 25 rue Becquerel, F-67087 Strasbourg Cedex 2, France.
Cerna
Igor
I
Campaniello
Maria
M
Leroux
Frédéric
F
Colobert
Françoise
F