title: Percutaneous ultrasound-guided biopsy in the definitive diagnosis of osteosarcoma.
abstract: Thirty-three patients with 35 bone lesions suspicious for osteosarcoma underwent image-guided biopsy. Of those 35 biopsies, 12 were performed with use of fluoroscopy or computed tomography (CT) guidance to target the osseous abnormality. Diagnostic magnetic resonance imaging revealed a soft tissue component in 23 cases; in these cases, biopsies were performed with use of ultrasonography (US) to target the soft tissue component of the tumor. Of the 35 tumors in which biopsy was performed, 33 (94%) were definitively diagnosed as osteosarcoma by image-guided biopsy. All 23 US-guided biopsies resulted in definitive diagnosis. Two of the 12 fluoroscopy- or CT-guided biopsies (17%) were inconclusive.
authors.affiliation: Department of Interventional Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA. kahrar@mdanderson.org
authors.forename: Kamran
authors.initials: K
authors.lastname: Ahrar
authors.forename: Judy U
authors.initials: JU
authors.lastname: Himmerich
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Herzog
authors.forename: A Kevin
authors.initials: AK
authors.lastname: Raymond
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Wallace
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
authors.forename: David C
authors.initials: DC
authors.lastname: Madoff
authors.forename: Frank A
authors.initials: FA
authors.lastname: Morello
authors.forename: Ravi
authors.initials: R
authors.lastname: Murthy
authors.forename: Stephen E
authors.initials: SE
authors.lastname: McRae
authors.forename: Marshall E
authors.initials: ME
authors.lastname: Hicks
mesh_terms: D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001707:Biopsy, Needle / Q000379:methods; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant / Q000379:methods; D002648:Child; D002945:Cisplatin / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005471:Fluoroscopy / Q000379:methods; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging / Q000473:pathology; D007867:Leg Bones / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D012516:Osteosarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D011884:Radius / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods; D014463:Ultrasonography / Q000379:methods*
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D004317:Doxorubicin; D002945:Cisplatin