Germacranolides from Calea urticifolia.
Four germacranolides, named calealactones A-C and calealactone B [corrected] were isolated from the leaves of Calea urticifolia (Compositae) in addition to three known germacranolides. Their structures were established on the basis of spectroscopic analysis including by 2D NMR spectroscopy. Calealactone C and 2,3-epoxyjuanisulamin displayed potent toxicity to U937 cells.
Yamada
Masashi
M
Development Section, Pharmaceuticals Department, Meiji Milk Product Co. Ltd., 1-26-11 Midori, Shimada-ku, Tokyo 130-8502, Japan.
Matsuura
Nobuyasu
N
Suzuki
Hiroto
H
Kurosaka
Chihiro
C
Hasegawa
Naoko
N
Ubukata
Makoto
M
Tanaka
Toshiyuki
T
Iinuma
Munekazu
M
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D006801:Humans; D007938:Leukemia; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020298:U937 Cells
D000972:Antineoplastic Agents, Phytogenic; D045788:Sesquiterpenes, Germacrane