Effects of a novel anti-hyperlipidemic agent, S-2E, on blood lipid levels in rats with fructose-induced hypertriglyceridemia.
Using rats with fructose-induced hypertriglyceridemia, an animal model of human hypertriglyceridemia, we investigated whether (+)-(S)-p-[1-(p-tert-butylphenyl)-2-oxo-4-pyrrolidinyl]-methoxybenzoic acid (S-2E), a novel anti-hyperlipidemic agent, reduced the elevated levels of triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C), and then whether it elevated HDL-C levels. At doses of 3-30 mg/kg, S-2E reduced elevated TG levels and non-HDL-C levels simultaneously in a dose-dependent manner after a week. Furthermore, S-2E treatment at 10 mg/kg for 4 weeks showed similar effects, while the elongation of intervals between feeding periods led to further increases in these levels. Interestingly, S-2E increased blood HDL-C levels after 4 weeks of treatment. It is therefore reasonable to assume that S-2E may be useful to improve dyslipidemia such as hypertriglyceridemia and low levels of HDL-C.
Ohmori
Koichi
K
Pharmacobioregulation Research Laboratory, Taiho Pharmaceutical Co, Ltd, Hanno, Saitama, Japan. k-ohmori@taiho.co.jp
Yamada
Haruo
H
Yasuda
Akio
A
Yamamoto
Akira
A
Matsuura
Naosuke
N
Kiniwa
Mamoru
M
D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D001629:Bezafibrate / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004032:Diet; D005632:Fructose; D062425:Hydroxybenzoate Ethers; D015228:Hypertriglyceridemia / Q000097:blood* / Q000139:chemically induced; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
C482648:4-(1-(4-tert-butylphenyl)-2-oxo-4-pyrrolidinyl)methoxybenzoic acid; D001565:Benzoates; D008076:Cholesterol, HDL; D062425:Hydroxybenzoate Ethers; D000960:Hypolipidemic Agents; D008055:Lipids; D011760:Pyrrolidinones; D014280:Triglycerides; D005632:Fructose; D002784:Cholesterol; D001629:Bezafibrate