Benefit/risk of cyclosporine in rheumatoid arthritis.
Combination therapy has emerged as a crucial therapeutic tool to control aggressive rheumatoid arthritis (RA). Cyclosporine (CsA) when combined with methotrexate (MTX) has shown substantial benefit in clinical practice. The primary benefit is its positive effect in the control of joint-bone erosions. The most feared adverse effect is the development of nephrotoxicity, which may be in part hemodynamic and in part structural, i.e. fibrotic. Careful monitoring of concomitant drugs, hypertension and through blood levels should allow the patient to maintain normal renal function. The successful employment of CsA in lupus nephritis clearly supports this statement.
Gremese
E
E
Division of Rheumatology, Catholic University of the Sacred Heart, School of Medicine, CIC-Via Moscati 31, 00168 Rome, Italy.
Ferraccioli
G F
GF
D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D018570:Risk Assessment
D018501:Antirheumatic Agents; D016572:Cyclosporine