A very reliable method for determination of absolute configuration of chiral secondary alcohols by 1H NMR spectroscopy.
Surprisingly stable synperiplanar conformers of CFTA esters have led us to develop a new and very reliable method for assigning absolute configurations of even secondary alcohols having minimal structural differences, such as chiral benzhydrols and alpha-monodeuterated benzyl alcohols.
Takeuchi
Yoshio
Y
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan. takeuchi@ms.toyama-mpu.ac.jp
Fujisawa
Hidehito
H
Noyori
Ryoji
R