The E2F family: specific functions and overlapping interests.
The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding of the roles and functions of the E2F family has made enormous progress, with each discovery new questions arise. In this review, we summarise the most recent advances in the field and discuss the remaining key questions. In particular, we will focus on how specificity is achieved among the E2Fs.
Attwooll
Claire
C
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Lazzerini Denchi
Eros
E
Helin
Kristian
K
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D050684:E2F Transcription Factors; D005786:Gene Expression Regulation; D010641:Phenotype; D011485:Protein Binding; D014157:Transcription Factors / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D014157:Transcription Factors