title: New synthesis of PNA-3'DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras.
abstract: A new synthetic strategy to get the PNA-3'DNA linker with the monomethoxytrityl (Mmt) group as temporary protection of the backbone to be used for the synthesis of PNA/DNA chimeras was employed and a convenient strategy to obtain Mmt PNA monomers was developed. The synthetic strategies take advantage of the introduction of the acid-labile Mmt-protecting group in the first step.
authors.affiliation: Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy.
authors.forename: Domenica
authors.initials: D
authors.lastname: Musumeci
authors.forename: Giovanni N
authors.initials: GN
authors.lastname: Roviello
authors.forename: Margherita
authors.initials: M
authors.lastname: Valente
authors.forename: Roberto
authors.initials: R
authors.lastname: Sapio
authors.forename: Carlo
authors.initials: C
authors.lastname: Pedone
authors.forename: Enrico M
authors.initials: EM
authors.lastname: Bucci
mesh_terms: D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D015394:Molecular Structure; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D011993:Recombinant Fusion Proteins / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D020135:Peptide Nucleic Acids; D011993:Recombinant Fusion Proteins; D004247:DNA