Ocular manifestations of graft versus host disease.
OBJECTIVE
A review of the current literature regarding the ocular manifestations and management of graft versus host disease is presented.


RESULTS
A variety of systemic and topical anti-inflammatory or immunomodulatory agents, including prednisolone acetate, cyclosporine A, FK506, autologous serum, and retinoic acid show promise in controlling ocular graft versus host disease.


CONCLUSIONS
Graft versus host disease is a common manifestation of allogeneic stem cell transplantation. Ocular manifestations are found in a majority of patients and may be the presenting symptom. Ocular findings include keratoconjunctivitis sicca, pseudomembranous conjunctivitis, corneal ulceration and perforation, and microvascular retinopathy. Systemic and local therapy may be used to control ocular disease.
Anderson
Nicholas G
NG
Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania 19107, USA.
Regillo
Carl
C
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D005128:Eye Diseases / Q000188:drug therapy / Q000209:etiology*; D006086:Graft vs Host Disease / Q000150:complications* / Q000209:etiology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D014184:Transplantation, Homologous / Q000009:adverse effects
D000893:Anti-Inflammatory Agents; D007155:Immunologic Factors