Genetic analysis of 18 X-linked short tandem repeat markers in Korean population.
The population genetic data of 18 X-chromosomal short tandem repeat (STR) markers DXS6807, DXS8378, DXS9895, DXS9902, DXS6810, DXS7132, DXS981, DXS6800, DXS9898, DXS6789, DXS101, DXS6797, GATA172D05, GATA165B12, HPRTB, GATA31E08, DXS8377, and DXS7423 were analyzed in samples of unrelated 220 males and 181 females from Korean population. The exact test for genotype distribution of the markers showed no significant deviation from the Hardy-Weinberg equilibrium. Allele frequencies between male and female samples were not significantly different in all examined markers. All examined males and females showed different hemizygotic haplotype and combined genotypes, respectively. Four cases of mutation were found in GATA172D05, GATA31E08, DXS7132, and HPRTB from the analysis of 95 father-child-mother trios. Details of X chromosomal STRs in Koreans would be useful in paternity tests and forensic purposes as well as whole X-chromosomal mapping studies.
Shin
Sang Hee
SH
Department of Biological Science, Kongju National University, 182 Sinkwan-dong, Kongju, Chungnam 314-701, South Korea.
Yu
Jin Seok
JS
Park
Sun Wha
SW
Min
Gi Sik
GS
Chung
Ki Wha
KW
D044466:Asian People / Q000235:genetics*; D041321:Chromosomes, Human, X; D016172:DNA Fingerprinting / Q000379:methods; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D020080:Tandem Repeat Sequences
D005819:Genetic Markers