title: Adverse oral reactions associated with the COX-2 inhibitor rofecoxib.
abstract: Rofecoxib is an inhibitor of the enzyme cyclo-oxygenase 2 (COX-2) used as an analgesic and anti-inflammatory agent especially in rheumatoid arthritis and osteoarthritis. The adverse effects are generally less than with other anti-inflammatory drugs (NSAIDs), and no oral adverse reactions have been reported in the literature. We present three cases of oral lesions caused by rofecoxib. Extensive erosions appeared, which in all cases resolved on withdrawal of the drug.
authors.affiliation: Valencia University, University General Hospital, Valencia, Spain. bagan@uv.es
authors.forename: J V
authors.initials: JV
authors.lastname: Bagán
authors.forename: K
authors.initials: K
authors.lastname: Thongprasom
authors.forename: C
authors.initials: C
authors.lastname: Scully
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007783:Lactones / Q000009:adverse effects*; D017512:Lichenoid Eruptions / Q000139:chemically induced*; D019226:Oral Ulcer / Q000139:chemically induced*; D013450:Sulfones / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib