The fluorescence of thyroid tissue.
OBJECTIVE
To investigate the fluorescent characteristics of different thyroid tissues.


METHODS
Fresh ex vivo thyroid tissue was surfaced scanned with a fluorescence spectrophotometer. Resultant spectra were evaluated via interpeak ratios.


RESULTS
Interpeak ratios of all histologies were found to be significantly different from each other (P < 0.001). The diagnostic sensitivity and specificity of fluorescent spectroscopy was 86% and 91% for thyroid nodule capsule, 78% and 59% for papillary thyroid carcinoma, and 82% and 63% for normal thyroid, respectively.


CONCLUSIONS
Fluorescent spectroscopy can been used to identify significant differences in the fluorescent characteristics of various thyroid histologies.


CONCLUSIONS
This study is the first investigation of the fluorescence of thyroid tissue. The diagnostic ability of fluorescent spectrometry may allow it to be used as a localization aid for fine needle aspiration, using optical fiber probes. Further investigations may enhance the sensitivity and specificity of fluorescent spectrometry allowing it to replace or compliment fine needle aspiration.


METHODS
B-3.
Pitman
Michael Jay
MJ
Department of Otolaryngology, New York Eye and Ear Infirmary, New York, USA.
Rosenthal
Joshua Michael
JM
Savage
Howard E
HE
Yu
Goupei
G
McCormick
Steven A
SA
Katz
Alvin
A
Alfano
Robert R
RR
Schantz
Stimson Pryor
SP
D000231:Adenocarcinoma, Papillary / Q000473:pathology; D000465:Algorithms; D005453:Fluorescence; D006801:Humans; D013050:Spectrometry, Fluorescence; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology*; D016606:Thyroid Nodule / Q000473:pathology