Associations between UVR exposure and basal cell carcinoma site and histology.
While sunlight is critical in basal cell carcinoma (BCC) pathogenesis the relationship between exposure and tumor site and histology is unclear. We determined if tumor site (trunk or head/neck) or histology (nodular or superficial) is determined by exposure pattern. In 66 cases with truncal and 362 patients with head/neck BCC at first presentation, average hours exposure/year, intermittency score, childhood sunburning and skin type were not significantly associated with tumor site or histology. However, often sunbathing was associated with a five-fold increased risk of truncal BCC. Average sunbathing score was significantly greater in 22 cases with truncal compared with 325 cases with head/neck nodular tumors and also in 44 cases with superficial truncal compared with superficial head/neck BCC. Thus, sunbathing determined tumor site but not histology.
Lovatt
Tracy J
TJ
Institute of Science and Technology in Medicine, Keele University School of Medicine, Hartshill Campus, University Hospital of North Staffordshire, Staffordshire, UK.
Lear
John T
JT
Bastrilles
Jean
J
Wong
Christina
C
Griffiths
Christopher E M
CE
Ramachandran
Sudarshan
S
Smith
Andrew G
AG
Salim
Asad
A
Fryer
Anthony A
AA
Jones
Peter W
PW
Strange
Richard C
RC
D000005:Abdomen; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D004739:England / Q000453:epidemiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D013471:Sunburn / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013909:Thorax; D014466:Ultraviolet Rays