title: Is autism an autoimmune disease?
abstract: Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impaired social interaction and communication, often accompanied by repetitive and stereotyped behavior. The condition manifests within the first 3 years of life and persists into adulthood. There are numerous hypotheses regarding the etiology and pathology of ASD, including a suggested role for immune dysfunction. However, to date, the evidence for involvement of the immune system in autism has been inconclusive. While immune system abnormalities have been reported in children with autistic disorder, there is little consensus regarding the nature of these differences which include both enhanced autoimmunity and reduced immune function. In this review, we discuss current findings with respect to immune function and the spectrum of autoimmune phenomena described in children with ASD.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, and UC Davis M.I.N.D. Institute, University of California, Davis, CA 95616, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Ashwood
authors.forename: Judy
authors.initials: J
authors.lastname: Van de Water
mesh_terms: D001321:Autistic Disorder / Q000276:immunology* / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology; D006801:Humans; D015213:Neuroimmunomodulation / Q000276:immunology*; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D015262:Xenobiotics