Cellular and physiological effects of short-chain fatty acids.
Short chain fatty acids (SCFA) have multiple in vivo and in vitro effects including cell cycle arrest and induction of protein synthesis, differentiation, and apoptosis. Butyrate or derivatives have promise for treating inflammatory bowel disease and colon cancer. Genomic and proteomic analysis have generated new knowledge on function and applications for SCFA.
Miller
Steven J
SJ
Clarian Health Partners, Inc, 1812 N Capital Ave Indianapolis, IN 46202, USA. smiller@clarian.org
D000818:Animals; D002087:Butyrates / Q000378:metabolism / Q000494:pharmacology; D005232:Fatty Acids, Volatile / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D013927:Thrombosis / Q000209:etiology / Q000628:therapy
D002087:Butyrates; D005232:Fatty Acids, Volatile