Urinary corticoid:creatinine ratios in healthy pet dogs after oral low-dose dexamethasone suppression tests.
Eleven dogs were used in a trial to find a suitable dose of dexamethasone for an oral dexamethasone suppression test for the diagnosis of hyperadrenocorticism. Basal urinary corticoid:creatinine ratios were established in all 11 and then groups of seven were given oral doses of 0.02, 0.01 or 0.0075 mg dexamethasone/kg bodyweight and urine samples were collected at two-hour intervals from 08.00 to 22.00. The doses of 0.02 and 0.01 mg/kg consistently suppressed their urinary corticoid:creatinine ratios measured at 16.00 by a mean of more than 50 per cent and those of individual dogs to less than 1.0 x 10(-6), whereas the dose of 0.0075 mg/kg did not.
Vaessen
M M A R
MM
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, PO Box 80154, 3508 TD, The Netherlands.
Kooistra
H S
HS
Mol
J A
JA
Rijnberk
A
A
D000284:Administration, Oral; D000304:Adrenal Cortex Function Tests / Q000662:veterinary; D000818:Animals; D003404:Creatinine / Q000652:urine*; D003907:Dexamethasone / Q000008:administration & dosage* / Q000378:metabolism; D004285:Dogs / Q000652:urine*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000652:urine*; D008297:Male; D012016:Reference Values
D005938:Glucocorticoids; D003907:Dexamethasone; D003404:Creatinine