title: [Evaluation of prophylactic hepatic arterial infusion chemotherapy after curative hepatectomy for metastatic colorectal cancer].
abstract: We evaluated the effect of hepatic arterial infusion (HAI) chemotherapy after curative resection of liver metastases of colorectal cancer. A total of 161 patients underwent curative resection of liver metastases. Among them, 50 patients underwent HAI of 5-FU, and 111 patients had no HAI therapy. The 50% disease-free survival time (50% DFS) was 758 days and 342 days in the HAI group and the non-HAI group (logrank test, p<0.01), and the 50% overall survival time (50% OS) was 978 days versus 730 days (p<0.05), respectively. Among the 71 patients with multiple resectable metastases (H2 or H3), the HAI group had a significantly superior 50% DFS. HAI therapy seems to be an effective form of adjuvant chemotherapy after hepatic resection of metastatic colorectal cancer.
authors.affiliation: Dept. of Surgery, National Hospital Organization Osaka National Hospital.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Tokuoka
authors.forename: Masaki
authors.initials: M
authors.lastname: Kashiwazaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Hasuike
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mishima
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ikenaga
authors.forename: Norikazu
authors.initials: N
authors.lastname: Masuda
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hirao
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Fujitani
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sawamura
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tsujinaka
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005472:Fluorouracil / Q000008:administration & dosage*; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D008113:Liver Neoplasms / Q000401:mortality / Q000517:prevention & control* / Q000556:secondary*; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil