title: Novel biodegradable copolyesters containing blocks of poly(3-hydroxyoctanoate) and poly(epsilon-caprolactone): synthesis and characterization.
abstract: Novel biodegradable polyester block copolymers have been synthesized by using well-defined poly(3-hydroxyoctanoate) (PHO) oligomers having a hydroxyl end group and an ester end group with M(n) values of 800, 2,500, 5,300, 8,000, or 20,000 as an elastomeric soft segment and poly(epsilon-caprolactone) as a more crystalline segment. These PHO oligomers prepared by methanolysis were subjected to block copolymerization with epsilon-caprolactone. The chemical structure of the copolymers was confirmed by (1)H NMR and (13)C NMR spectroscopy. All the copolyesters are semi-crystalline and two T(g) were observed by differential scanning calorimetry when the molecular weight of the PHO block is about 20,000.
authors.affiliation: LRP, UMR 7581, Université Paris XII, 2 à 8, rue H. Dunant, 94 320 Thiais, France.
authors.forename: Laurianne
authors.initials: L
authors.lastname: Timbart
authors.forename: Estelle
authors.initials: E
authors.lastname: Renard
authors.forename: Valérie
authors.initials: V
authors.lastname: Langlois
authors.forename: Philippe
authors.initials: P
authors.lastname: Guerin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D001673:Biodegradation, Environmental; D002210:Caprylates / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D002210:Caprylates; D011091:Polyesters; C016240:polycaprolactone; C101940:3-hydroxyoctanoic acid