A contemporary understanding of progesterone receptor function.
Following the discovery of coactivators for nuclear receptors and the identification of a significant number of progesterone receptor (PR) target genes, our understanding of PR action has extended from its normally recognized functions to a wide variety of seemingly unlinked biological processes. Recent advances in defining the action of PR coactivators has revealed important mechanisms involving multiple layers of regulation in PR-mediated transcription. In this review, we will discuss the current understanding of PR physiology and the molecular basis of coactivator function in PR signaling events.
Li
Xiaotao
X
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Lonard
David M
DM
O'Malley
Bert W
BW
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D011374:Progesterone / Q000502:physiology*; D011980:Receptors, Progesterone / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D011980:Receptors, Progesterone; D011374:Progesterone