[Intraperitoneal chemotherapy against peritoneal carcinomatosis of gastric cancer with activated carbon particles adsorbing mitomycin C for four patients].
Activated carbon particles adsorbing mitomycin C (MMC-CH) was administered to four patients with peritoneal carcinomatosis of gastric cancer into their abdominal cavities. Tumor markers of CEA, CA19-9, CA125, CA72-4 and STN were measured before and after the administration. The waist of each patient was also measured. After the administration of MMC-CH, tumor markers of three out of the four patients were decreased and a large amount of ascites of all patients had disappeared. The appetite of all four patients had increased and complaints such as nausea and vomiting had decreased. The mean survival of the four patients was 291.2 days (123-542 days). Our results suggested that MMC-CH had an anti-tumor effect of peritoneal carcinomatosis and improved the QOL of patients with a large amount of ascites.
Ohgaki
Masaharu
M
Dept of Surgery, Kyoto Second Red Cross Hospital.
Takenaka
Atsushi
A
Shiomi
Akio
A
Chou
Hideyuki
H
Takashina
Kenichiro
K
Kawakami
Sadao
S
Fujita
Yoshihiro
Y
Hagiwara
Akeo
A
Yamagishi
Hisakazu
H
D000327:Adsorption; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001201:Ascites / Q000188:drug therapy*; D014408:Biomarkers, Tumor / Q000032:analysis; D002606:Charcoal / Q000008:administration & dosage*; D004304:Dosage Forms; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
D000903:Antibiotics, Antineoplastic; D014408:Biomarkers, Tumor; D004304:Dosage Forms; D002606:Charcoal; D016685:Mitomycin