Deterministic and stochastic modelling of endosome escape by Staphylococcus aureus: "quorum" sensing by a single bacterium.
Deterministic and stochastic models describing quorum sensing by Staphylococcus aureus within an endosome, and the subsequent escape via the production of virulence factors, are developed and analysed. Particular attention is given to a biologically-relevant asymptotic limit of the problem, for which the solutions, including the endosome escape time, can be explicitly characterised in terms of the model parameters.
Koerber
A J
AJ
Centre for Mathematical Medicine, Theoretical Mechanics Section, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
King
J R
JR
Williams
P
P
D003198:Computer Simulation; D011992:Endosomes / Q000382:microbiology*; D008954:Models, Biological; D009010:Monte Carlo Method; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D013269:Stochastic Processes; D014774:Virulence