title: Comparative study of proton and phosphorus magnetic resonance spectroscopy in schizophrenia at 4 Tesla.
abstract: This study used high-field magnetic resonance spectroscopy to examine the correlation of 1H and 31P metabolite levels in patients with schizophrenia and normal controls. 1H and 31P in vivo spectra were acquired successively from the left anterior cingulate and left thalamus of nine chronic schizophrenic patients and eight comparable healthy controls. A significant positive correlation between glutamine (Gln) and phosphoethanolamine (PEtn) was found in the left anterior cingulate of patients. In the left thalamus of patients, a significant negative correlation between N-acetylaspartate (NAA) and glycerophosphocholine (GroPCho) was found. No significant correlations were found in controls. The correlation between glutamine and phosphoethanolamine may reflect a link between neurotransmission alterations and membrane phospholipid metabolism alterations. The negative correlation between N-acetylaspartate and glycerophosphocholine may reflect the presence of neurodegeneration.
authors.affiliation: Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Théberge
authors.forename: Yousef
authors.initials: Y
authors.lastname: Al-Semaan
authors.forename: J Eric
authors.initials: JE
authors.lastname: Jensen
authors.forename: Peter C
authors.initials: PC
authors.lastname: Williamson
authors.forename: Richard W J
authors.initials: RW
authors.lastname: Neufeld
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Menon
authors.forename: Betsy
authors.initials: B
authors.lastname: Schaefer
authors.forename: Maria
authors.initials: M
authors.lastname: Densmore
authors.forename: Dick J
authors.initials: DJ
authors.lastname: Drost
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009410:Nerve Degeneration / Q000473:pathology; D010743:Phospholipids / Q000378:metabolism*; D010758:Phosphorus / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011522:Protons; D012559:Schizophrenia / Q000175:diagnosis* / Q000473:pathology
chemical_list: D010743:Phospholipids; D011522:Protons; D010758:Phosphorus