title: Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia.
abstract: Reports on the prognostic impact of mutations in the RAS proto-oncogenes in patients with acute myeloid leukemia (AML) are conflicting. A peptide nucleic acid (PNA)-based technique was used on 232 AML samples to detect point mutations of the hotspots in N-RAS and K-RAS. No significant correlations between RAS mutations and clinical features, karyotype or FLT3 were found.
authors.forename: Markus
authors.initials: M
authors.lastname: Ritter
authors.forename: Theo Daniel
authors.initials: TD
authors.lastname: Kim
authors.forename: Petra
authors.initials: P
authors.lastname: Lisske
authors.forename: Christian
authors.initials: C
authors.lastname: Thiede
authors.forename: Markus
authors.initials: M
authors.lastname: Schaich
authors.forename: Andreas
authors.initials: A
authors.lastname: Neubauer
mesh_terms: D000208:Acute Disease; D000328:Adult; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000235:genetics*; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D017354:Point Mutation; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic