title: The role of thrombospondin-1 in human disease.
abstract: Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein secreted by many cell types. It is a component of the extracellular matrix during active and subacute processes. Due to TSP-1's ability to interact with a variety of matrix proteins and cell-surface receptors, controversy exists about its conflicting functions. In this review, we will discuss the role of TSP-1 in human disease.
authors.affiliation: Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Nowokere
authors.initials: N
authors.lastname: Esemuede
authors.forename: Taeseung
authors.initials: T
authors.lastname: Lee
authors.forename: Daphne
authors.initials: D
authors.lastname: Pierre-Paul
authors.forename: Bauer E
authors.initials: BE
authors.lastname: Sumpio
authors.forename: Vivian
authors.initials: V
authors.lastname: Gahtan
mesh_terms: D004194:Disease; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000378:metabolism; D018919:Neovascularization, Physiologic; D010974:Platelet Aggregation; D019700:Thrombospondin 1 / Q000378:metabolism*; D014652:Vascular Diseases / Q000503:physiopathology; D014945:Wound Healing
chemical_list: D019700:Thrombospondin 1