Synthesis, structure, and cytostatic properties of new olivacine derivatives.
Starting from 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine and 6-methylpicolinic acid, 9-methoxy-5-methyl-1-(6-methylpyridin-2-yl)-6H-pyrido[4,3-b]carbazole 10 and its 6-alkylderivatives 12-17 were obtained. The newly obtained compounds showed significant cytostatic activity against cultured L1210 cells and high cytotoxicity towards various human tumor cell lines.
Jasztold-Howorko
Ryszard
R
Wrocław University of Medicine, Faculty of Pharmacy, Department of Organic Chemistry, Wrocław, Poland. howorko@bf.uni.wroc.pl
Croisy
Alain
A
Carrez
Daniele
D
Jaroszewicz
Iwona
I
Nasulewicz
Anna
A
Pełczyńska
Marzena
M
Opolski
Adam
A
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D004354:Drug Screening Assays, Antitumor; D004611:Ellipticines / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice
D000972:Antineoplastic Agents, Phytogenic; D004611:Ellipticines; D007202:Indicators and Reagents; C011521:olivacine