title: Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles.
abstract: A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Almasirad
authors.forename: Sayyed A
authors.initials: SA
authors.lastname: Tabatabai
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Faizi
authors.forename: Abbas
authors.initials: A
authors.lastname: Kebriaeezadeh
authors.forename: Nazila
authors.initials: N
authors.lastname: Mehrabi
authors.forename: Afshin
authors.initials: A
authors.lastname: Dalvandi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D010069:Oxadiazoles; D014230:Triazoles; C045575:1,2,4-triazole