title: Melanocortin-4 receptor agonists for the treatment of obesity.
abstract: The identification of a highly efficacious anti-obesity agent remains an illusive goal. While many avenues of investigation have been pursued, none of the existing compounds claim much more than a 10% reduction in weight in humans (over a one year period with diet and exercise). Nonetheless, the potential reward for fulfilling this unmet medical need has kept interest levels high in the research community. The recent explosion of genetic information has identified numerous potential targets for drug screening. The melanocortin-4 receptor is a promising target and is currently being intensively investigated by many companies and academic research groups.
authors.affiliation: Chiron Corp, 4560 Horton Street, Emeryville, CA 94608, USA. rustum_boyce@chiron.com
authors.forename: Rustum S
authors.initials: RS
authors.lastname: Boyce
authors.forename: David M
authors.initials: DM
authors.lastname: Duhl
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists*; D013329:Structure-Activity Relationship; D013386:Succinates
chemical_list: D000577:Amides; D010456:Peptides, Cyclic; D010879:Piperazines; D044105:Receptor, Melanocortin, Type 4; D013386:Succinates; C011116:succinamide