Time course of inflammatory response after renal artery stenting in patients with atherosclerotic renal stenosis.
BACKGROUND
Inflammatory response has been demonstrated in patients with coronary artery disease after percutaneous coronary intervention (PCI). Such response following renal artery stenting has not yet been established, however, in patients with atherosclerotic renal artery stenosis.


METHODS
A total of 44 patients were enrolled in this study. Of them, 22 patients with atherosclerotic renal artery stenosis received renal angioplasty with stent (group A, mean age 51+/-8 years), and 22 patients with age- and gender-matched underwent renal angiography for diagnostic purpose as a control group (group B, age 50+/-8 years). The peripheral blood samples were taken immediately before the procedure, 1, 6 and 24 h after the procedure in both groups. The concentrations of C-reactive protein (CRP) and interleukin-6 (IL-6) were measured using ELISA.


RESULTS
The result showed that there was no difference in clinical characteristics and baseline levels of CRP and IL-6 between the groups. The IL-6 increased in the first hour (before: 5.8+/-3 pg/ml; 1 h: 8.6+/-5 pg/ml, p<0.01), lasted at 6 h (12.2+/-8 pg/ml), returned to baseline at 24 h (5.4+/-3 pg/ml) in group A. The CRP did not changed at the first hour after stenting, but mean CRP increased from 0.30+/-0.09 to 0.37+/-0.15 mg/dl at 6 h (p<0.05), and peaked at 24 h (0.43+/-0.18 mg/dl, p<0.001 compared with baseline and control) after stenting in group A, while no such changes were observed in group B (p>0.05 at different time points compared with baseline and group B, respectively).


CONCLUSIONS
The data indicated that renal artery stenting could trigger inflammatory response by evidence of increased plasma levels of CRP and IL-6. IL-6, however, was an early initiator of inflammatory cytokine, and CRP was a later marker of systemic inflammatory response to renal artery stenting.
Li
Jian-Jun
JJ
Renmin Hospital, Wuhan University School of Medicine, Wuhan 430060, PR China. lijnjn@yahoo.com.cn
Fang
Chun-Hong
CH
Jiang
Hong
H
Huang
Cong-Xin
CX
Hui
Ru-Tai
RT
Chen
Ming-Zhe
MZ
D000328:Adult; D017130:Angioplasty / Q000379:methods; D001161:Arteriosclerosis / Q000628:therapy*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis; D017023:Coronary Angiography / Q000009:adverse effects; D016207:Cytokines / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D007668:Kidney / Q000378:metabolism; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000209:etiology / Q000628:therapy*; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6; D002097:C-Reactive Protein