Synthesis of fused polycycles by 1,4-palladium migration chemistry.
Novel palladium migration/arylation methodology for the synthesis of complex fused polycycles has been developed, in which one or more sequential Pd-catalyzed intramolecular migration processes involving C-H activation are employed. The chemistry works best with electron-rich aromatics, which is in agreement with the idea that these palladium-catalyzed C-H activation reactions parallel electrophilic aromatic substitution.
Huang
Qinhua
Q
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Campo
Marino A
MA
Yao
Tuanli
T
Tian
Qingping
Q
Larock
Richard C
RC
D002384:Catalysis; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D006576:Heterocyclic Compounds, 4 or More Rings; D011083:Polycyclic Compounds; D010165:Palladium