AMPA receptors bring on the pain.
The role of Ca(2+)-permeable AMPA receptors in pain processing has not been extensively studied. In this issue of Neuron, Hartmann et al. show that altering the levels of these receptors has consequences for inflammatory pain hypersensitivity but not acute pain processing.
Torsney
Carole
C
Department of Physiology and Cellular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA.
Macdermott
Amy B
AB
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D018091:Receptors, AMPA / Q000502:physiology*
D018091:Receptors, AMPA