Interleukin-18 and interleukin-18 binding protein levels before and after percutaneous coronary intervention in patients with and without recent myocardial infarction.
Serum levels of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein were measured in 84 patients before and after coronary angioplasty. Patients who had high levels of troponin I immediately before angioplasty were considered to have experienced a "recent" myocardial infarction. Concentrations of IL-18 (355 vs 316 pg/ml) and ratio of IL-18 to IL-18 binding protein (107 vs 69) were significantly higher among patients who had recent myocardial infarction than among those who did not, indicating a relation between unopposed IL-18 activity and recent myocardial infarction.
Narins
Craig R
CR
Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. craig_narins@urmc.rochester.edu
Lin
David A
DA
Burton
Paul B
PB
Jin
Zheng-Gen
ZG
Berk
Bradford C
BC
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000628:therapy; D019210:Troponin I / Q000097:blood
D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D020382:Interleukin-18; D019210:Troponin I; C118370:interleukin-18 binding protein