Nucleocapsid protein as early diagnostic marker for SARS.
Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6-10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.
Che
Xiao-Yan
XY
Center of Laboratory, Zhujiang Hospital, First Military Medical University, Guangzhou, People's Republic of China. linche@pub.guangzhou.gd.cn
Hao
Wei
W
Wang
Yadi
Y
Di
Biao
B
Yin
Kai
K
Xu
Yin-Chao
YC
Feng
Chang-Sen
CS
Wan
Zhuo-Yue
ZY
Cheng
Vincent C C
VC
Yuen
Kwok-Yung
KY
D000914:Antibodies, Viral / Q000097:blood; D015415:Biomarkers; D006801:Humans; D019590:Nucleocapsid Proteins / Q000097:blood*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000302:isolation & purification*; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis*; D013997:Time Factors
D000914:Antibodies, Viral; D015415:Biomarkers; D019590:Nucleocapsid Proteins