Enantioselective allylic substitution of cinnamyl esters catalyzed by iridium-chiral aryl phosphite complex: conspicuous change in the mechanistic spectrum by a countercation and solvent.
Iridium-catalyzed asymmetric allylic alkylation of monoaryl substrates 4-6 with chiral phosphites 1-3 has been investigated. Although branched isomers were formed with high regioselectivities, the enantioselectivities of these products were remarkably influenced by solvents, countercations, and additives (ZnCl(2) and LiCl).
Kinoshita
Naosumi
N
Medicinal Chemistry Research Institute, Otsuka Pharmaceutical Company, Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan.
Marx
Karsten H
KH
Tanaka
Kiyoshi
K
Tsubaki
Kazunori
K
Kawabata
Takeo
T
Yoshikai
Naohiko
N
Nakamura
Eiichi
E
Fuji
Kaoru
K