A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes.
Copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of nonfluorescent 3-azidocoumarins and terminal alkynes afforded intense fluorescent 1,2,3-triazole products. The mild condition of this reaction allowed us to construct a large library of pure fluorescent coumarin dyes. Since both azide and alkyne are quite inert to biological systems, this reaction has potential in bioconjugation and bioimaging applications. [reaction: see text]
Sivakumar
Krishnamoorthy
K
Department of Chemistry & Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA.
Xie
Fang
F
Cash
Brandon M
BM
Long
Su
S
Barnhill
Hannah N
HN
Wang
Qian
Q