title: Localized granulomatous reaction to a semi-permanent hyaluronic acid and acrylic hydrogel cosmetic filler.
abstract: Dermalive, an injectable skin filler composed of a combination of synthetic hyaluronic acid and acrylic hydrogel particles was recently developed for soft tissue augmentation. Dermalive produces longer term results than temporary injectable fillers and is associated with a reportedly low incidence of adverse reactions. We describe a marked local reaction to the injection of Dermalive in the nasolabial fold developing within 4 months with histological confirmation of a granulomatous response. To our knowledge there has been only one previous report of a local granulomatous reaction to Dermalive.
authors.affiliation: Department of Dermatology, Royal Free Hospital, London, UK.
authors.forename: R U
authors.initials: RU
authors.lastname: Sidwell
authors.forename: A P
authors.initials: AP
authors.lastname: Dhillon
authors.forename: P E M
authors.initials: PE
authors.lastname: Butler
authors.forename: M H A
authors.initials: MH
authors.lastname: Rustin
mesh_terms: D000179:Acrylates / Q000009:adverse effects*; D000328:Adult; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D020100:Hydrogels / Q000009:adverse effects*; D015361:Rhytidoplasty / Q000009:adverse effects* / Q000379:methods
chemical_list: D000179:Acrylates; C482306:Dermalive; D020100:Hydrogels; D006820:Hyaluronic Acid