Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome.
We report a case of Waldenstrom's macroglobulinemia (WM) presenting as classic Goodpasture's syndrome. Thrombocytopenia, an additional autoimmune phenomenon, further complicated the clinical course. Renal disease is well recognized in Waldenstrom's macroglobulinemia and other B-cell dyscrasias. Similarly, a wide spectrum of autoimmune-mediated conditions has been reported in association with paraproteinemia. However, rapidly progressive glomerulonephritis in association with antiglomerular basement membrane antibodies has never been reported as either an autoimmune or a renal manifestation of WM. This article reviews the current understanding of renal pathology and autoimmune phenomenon associated with WM.
Gandhi
Sonia
S
Renal Section, Division of Medicine, Imperial College, Hammersmith Hospital, London, UK.
Little
Mark A
MA
Farrington
Ken
K
D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D051437:Renal Insufficiency / Q000276:immunology; D013921:Thrombocytopenia / Q000276:immunology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000175:diagnosis* / Q000276:immunology