title: Effect of amiodarone on the plasma levels of metoprolol.
abstract: On average, metoprolol plasma concentration is doubled after an amiodarone loading dose (1.2 g/day over a period of 6 days). However, the individual amount of this drug interaction depends on the CYP2D6 genotype.
authors.affiliation: Department of Cardiology, Helios Clinic, Schwerin, Germany. dwerner@schwerin.helios-kliniken.de <dwerner@schwerin.helios-kliniken.de>
authors.forename: Dierk
authors.initials: D
authors.lastname: Werner
authors.forename: Henrike
authors.initials: H
authors.lastname: Wuttke
authors.forename: Martin F
authors.initials: MF
authors.lastname: Fromm
authors.forename: Simon
authors.initials: S
authors.lastname: Schaefer
authors.forename: Thomas
authors.initials: T
authors.lastname: Eschenhagen
authors.forename: Kay
authors.initials: K
authors.lastname: Brune
authors.forename: Werner G
authors.initials: WG
authors.lastname: Daniel
authors.forename: Ulrike
authors.initials: U
authors.lastname: Werner
mesh_terms: D000368:Aged; D000483:Alleles; D000638:Amiodarone / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000493:pharmacokinetics*
chemical_list: D000889:Anti-Arrhythmia Agents; D019389:Cytochrome P-450 CYP2D6; D008790:Metoprolol; D000638:Amiodarone