title: Cicatrizing and antimicrobial properties of an ozonised oil from sunflower seeds.
abstract: The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia coli suspensions using the agar diffusion method. Healing experiments were carried out with Wistar rats through topical application of 3.5 mg/ml of the ozonised oil up to the 7th day after inoculation with S. aureus. Bioperoxoil showed anti-inflammatory effects against all strains tested, with MIC values ranging from 2.0 to 3.5 mg/ml. Bioperoxoil also demonstrated protective effects on skin connective tissue and to enhance wound healing during the treatment, as compared to a neomycin-clostebol association used as a positive control. The overall results indicated a significant antimicrobial activity, anti-inflammatory and wound-healing properties for Bioperoxoil, as compared to other antimicrobial agents commercially available.
authors.affiliation: Laboratorio Biologia e Fisiologia de Microrganismos, Unifenas, Alfenas, MG, Brazil.
authors.forename: Kamila Leite
authors.initials: KL
authors.lastname: Rodrigues
authors.forename: Claudia Catellani
authors.initials: CC
authors.lastname: Cardoso
authors.forename: Lucelia Regina
authors.initials: LR
authors.lastname: Caputo
authors.forename: Jose Carlos Tavares
authors.initials: JC
authors.lastname: Carvalho
authors.forename: Joao Evangelista
authors.initials: JE
authors.lastname: Fiorini
authors.forename: Jose Mauricio
authors.initials: JM
authors.lastname: Schneedorf
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D008297:Male; D008826:Microbial Sensitivity Tests; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology; D000074242:Sunflower Oil; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D010938:Plant Oils; D000074242:Sunflower Oil