title: The evolution of experimental surgery in the field of morbid obesity.
abstract: BACKGROUND
  We reviewed the experimental surgery, related to bariatric surgery in laboratory animals, to consider new lines of research.
  
  
  METHODS
  The literature on experimental surgery for morbid obesity since the mid-20th century was reviewed, focusing on existing techniques (malabsorptive, restrictive, mixed and experimental) and their associated metabolic component.
  
  
  RESULTS
  In the field of laparoscopy, there is a clear tendency for large laboratory animals such as pigs to be used. These are useful for developing and perfecting techniques. A second area of animal experimentation concentrates on the relationship between metabolism and surgery in order to find improvements in the co-morbidities associated with morbid obesity. A third area of research focuses on manipulating intake via central and vagal control.
  
  
  CONCLUSIONS
  Further studies are needed to combine traditional and recently developed techniques of experimental surgery with the mechanisms that determine the physiopathology, metabolism and regulation of intake of morbidly obese patients. To accurately determine metabolic behavior and avoid drawing conclusions that are not very significant, these studies should be carried out on obese animals and focus on the co-morbidities associated with morbid obesity.
authors.affiliation: Department of Surgery, Faculty of Medicine and Sciences, Rovira i Virgilio University, Reus (Tarragona), Spain. ddelcastillo@grupsagessa.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Del Castillo Déjardin
authors.forename: Fàtima
authors.initials: F
authors.lastname: Sabench Pereferrer
authors.forename: Mercè
authors.initials: M
authors.lastname: Hernández González
authors.forename: Santiago
authors.initials: S
authors.lastname: Blanco Blasco
authors.forename: Magda
authors.initials: M
authors.lastname: Abelló Sala
mesh_terms: D000818:Animals; D049088:Bariatrics; D015904:Biliopancreatic Diversion / Q000266:history; D013505:Digestive System Surgical Procedures / Q000266:history*; D015390:Gastric Bypass / Q000266:history; D015391:Gastroplasty / Q000266:history; D049673:History, 20th Century; D006801:Humans; D007082:Ileum / Q000637:transplantation; D007581:Jejunoileal Bypass / Q000266:history; D009767:Obesity, Morbid / Q000601:surgery*