Diagnosis of rapid eye movement sleep disorder with electroencephalography and treatment with tricyclic antidepressants in a dog.
A 9-month-old, female Labrador retriever mix was presented for two types of seizure-like episodes, one of which occurred only during sleep. The two types of episodes were morphologically distinct. An electroencephalogram (EEG) demonstrated that the sleep-associated episodes occurred during rapid eye movement (REM) sleep, supporting a diagnosis of a REM behavior disorder. Based on their morphology and response to antiseizure medications, the waking episodes were diagnosed as seizures. The animal was also diagnosed with an obsessive-compulsive and generalized anxiety disorder. The REM behavior disorder and anxiety-related behaviors improved with tricyclic antidepressant therapy.
Bush
William W
WW
Veterinary Hospital, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Barr
Christina S
CS
Stecker
Mark M
MM
Overall
Karen L
KL
Bernier
Noemie M
NM
Darrin
Edwin W
EW
Morrison
Adrian R
AR
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D004285:Dogs; D004569:Electroencephalography / Q000379:methods / Q000662:veterinary*; D005260:Female; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000188:drug therapy; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D012895:Sleep, REM; D016896:Treatment Outcome
D000929:Antidepressive Agents, Tricyclic