title: [Efficacy of selective digestive decontamination (SDD) for severe acute pancreatitis].
abstract: Bacterial translocation (BT) is involved in the development of pancreatic infection in severe acute pancreatitis (SAP) and influences the prognosis. We should suppress BT to prevent pancreatic infection and improve survival rate. Selective digestive decontamination (SDD) is rational treatment. We should aim at effective SDD, ensuring the following 4 points: (1) enteral antimicrobials, in combination with, (2) parenteral antibiotics given immediately on admission, (3) hand hygiene, (4) surveillance cultures of throat and rectum. Starting enteral feeding as soon as possible and avoiding long-term SDD is useful for maintaining the defenses of the intestinal mucosa and preventing emergence of resistant bacteria. We used glutamine and dietary fiber besides SDD and were able to reduce pancreatic infection.
authors.affiliation: Department of Emergency and Critical Care Medicine, Kimitsu Chuo Hospital.
authors.forename: Nobuya
authors.initials: N
authors.lastname: Kitamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirano
authors.forename: Takeshi
authors.initials: T
authors.lastname: Moriguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hirasawa
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ohtani
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections; D018988:Bacterial Translocation; D003666:Decontamination / Q000379:methods*; D004043:Dietary Fiber / Q000008:administration & dosage; D004750:Enteral Nutrition; D005973:Glutamine / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D007362:Intensive Care Units; D010195:Pancreatitis / Q000382:microbiology* / Q000517:prevention & control / Q000628:therapy*; D010614:Pharynx / Q000382:microbiology; D012007:Rectum / Q000382:microbiology; D012720:Severity of Illness Index
chemical_list: D000900:Anti-Bacterial Agents; D004043:Dietary Fiber; D005973:Glutamine