T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction.
OBJECTIVE
To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction.


METHODS
Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique.


RESULTS
The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P < 0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P > 0.05).


CONCLUSIONS
The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentation of the C/C variant of 5-HT2A receptor gene in temporomandibular dysfunction suggests a possible role of the serotonergic system in this disease, particularly at the receptor level.
Mutlu
N
N
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Selcuk University, Konya, Turkey. nmutlu@selcuk.edu.tr
Erdal
M E
ME
Herken
H
H
Oz
G
G
Bayazit
Y A
YA
D000328:Adult; D000483:Alleles; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013705:Temporomandibular Joint Disorders / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A