title: Kinetics and clonality of immunological memory in humans.
abstract: T-cell immunological memory consists largely of clones of proliferating lymphocytes maintained by antigenic stimulation and the survival and proliferative effects of cytokines. The duration of survival of memory clones in humans is determine by the Hayflick limit on the number of cell divisions, the rate of cycling of memory cells and factors that control erosion of telomeres, including mechanisms that control telomerase.
authors.affiliation: The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG207NN, UK. peter.beverley@jenner.ac.uk
authors.forename: Peter C L
authors.initials: PC
authors.lastname: Beverley
mesh_terms: D049109:Cell Proliferation; D006801:Humans; D007156:Immunologic Memory; D007700:Kinetics; D008213:Lymphocyte Activation; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D019098:Telomerase / Q000502:physiology; D016615:Telomere / Q000502:physiology
chemical_list: D019098:Telomerase