title: Impact of inflammation and oxidative stress on vascular calcifications in chronic kidney disease.
abstract: Vascular and/or valvular calcifications in patients with chronic kidney disease (CKD) appear to indicate a poor prognosis in terms of overall survival and cardiovascular morbidity and mortality. Inflammation and oxidative stress represent new features of the arterial and/or valvular calcification process. However, only limited observational and epidemiological data are available in these areas. Therefore, the link between inflammation, oxidation and vascular and/or valvular calcifications deserves careful consideration in CKD patients, since they may become targets for the development of new therapeutic strategies.
authors.affiliation: EA2087, Amiens University Hospital, UPJV, Amiens, France. massy@u-picardie.fr
authors.forename: Z A
authors.initials: ZA
authors.lastname: Massy
authors.forename: C
authors.initials: C
authors.lastname: Mazière
authors.forename: S
authors.initials: S
authors.lastname: Kamel
authors.forename: M
authors.initials: M
authors.lastname: Brazier
authors.forename: G
authors.initials: G
authors.lastname: Choukroun
authors.forename: C
authors.initials: C
authors.lastname: Tribouilloy
authors.forename: M
authors.initials: M
authors.lastname: Slama
authors.forename: M
authors.initials: M
authors.lastname: Andrejak
authors.forename: J C
authors.initials: JC
authors.lastname: Mazière
mesh_terms: D002114:Calcinosis / Q000209:etiology* / Q000378:metabolism; D002648:Child; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000150:complications; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism; D018384:Oxidative Stress; D014652:Vascular Diseases / Q000209:etiology* / Q000378:metabolism