title: Successful treatment of hydromorphone-induced neurotoxicity and hyperalgesia.
abstract: There has been an increase in opioid consumption world wide in the last decade. There has also been a disturbing increase in the number of reports of neuroexcitatory opioid-related side effects observed in patients receiving large doses of systemically administered morphine and its structural analogue, hydromorphone. It is now becoming clearer that patients receiving long-term opioid therapy can develop unexpected pain. We describe an interesting case of successful management of hydromorphone-induced neurotoxicity and hyperalgesia produced by short-term therapy with rapidly escalating doses of systemic hydromorphone.
authors.affiliation: Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Keun Sam
authors.initials: KS
authors.lastname: Chung
authors.forename: Shawn
authors.initials: S
authors.lastname: Carson
authors.forename: David
authors.initials: D
authors.lastname: Glassman
authors.forename: Nalini
authors.initials: N
authors.lastname: Vadivelu
mesh_terms: D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage / Q000009:adverse effects*; D006930:Hyperalgesia / Q000139:chemically induced* / Q000534:rehabilitation; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D008875:Middle Aged; D009294:Narcotics / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000534:rehabilitation; D010146:Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D009294:Narcotics; D004091:Hydromorphone; D008691:Methadone