Surprising versatility of Na+-glucose cotransporters: SLC5.
SLC5 is an ancient gene family with 11 members in the human genome. These membrane proteins have diverse, multiple functions ranging from actively transporting solutes, ions, and water, to channeling water and urea, to sensing glucose in cholinergic neurons. Metabolic disorders have been identified that are associated with congenital mutations in two of the human genes.
Wright
Ernest M
EM
Department of Physiology, The David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California 90095-1751, USA. ewright@mednet.ucla.edu
Loo
Donald D F
DD
Hirayama
Bruce A
BA
Turk
Eric
E
D000818:Animals; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D009004:Monosaccharide Transport Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D005810:Multigene Family / Q000502:physiology*; D017434:Protein Structure, Tertiary; D012964:Sodium / Q000378:metabolism*; D051269:Sodium-Glucose Transporter 1
D008562:Membrane Glycoproteins; D009004:Monosaccharide Transport Proteins; C495674:SLC5A1 protein, human; D051269:Sodium-Glucose Transporter 1; D012964:Sodium; D005947:Glucose