[Galanin immunoreactivity in a laryngeal paraganglioma: case report and literature review].
The authors describe a case of laryngeal paraganglioma (LP) occurring in a 57-year-old-woman. To date, 70 cases have been described in the literature. It is benign and recurrences are infrequent. The differential diagnosis with typical and atypical carcinoids, hemangiopericytomas, alveolar soft-part sarcomas, medullary thyroid carcinomas, malignant melanomas and metastatic renal cell carcinomas is supported by immunohistochemistry. Moreover, this tumor shows the immunohistochemical expression of galanin, a variably expressed marker of paragangliomas that it is not expressed in carcinoid tumors. Nevertheless, our observations militate against its role as a solitary marker but advocate its use in conjunction with other antibodies for the differential diagnosis of neuroendocrine neoplasms of larynx.
Squillaci
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Unità Operativa di Anatomia Patologica, Ospedale di Vallecamonica, Esine, Brescia. apesine@hotmail.com
Gal
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AA
D005260:Female; D019004:Galanin / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008875:Middle Aged; D010235:Paraganglioma / Q000378:metabolism* / Q000473:pathology*
D019004:Galanin