title: Synthesis of arbutin by two-step reaction from glucose.
abstract: Arbutin was synthesized from glucose by two-step reaction below: (a) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl chloride or bromide was prepared by glucose and acetyl halide (chloride or bromide). (b) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl halide (Cl, Br) reacted with hydroquinone, methanol as solvent at pH=9.5-10.0.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Shen-Lin
authors.initials: SL
authors.lastname: Huang
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Zhu
authors.forename: Yuan-Jiang
authors.initials: YJ
authors.lastname: Pan
authors.forename: Shi-Hua
authors.initials: SH
authors.lastname: Wu
mesh_terms: D000107:Acetylation; D001104:Arbutin / Q000138:chemical synthesis*; D001965:Bromides / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*
chemical_list: D001965:Bromides; D002712:Chlorides; D001104:Arbutin; D005947:Glucose