title: The value of omentoplasty in protecting colorectal anastomosis from leakage. A prospective randomized study in 126 patients.
abstract: OBJECTIVE
  Anastomotic leakage is a major cause of mortality in colorectal surgery. Several methods have been evaluated in order to prevent anastomotic leakage. To decrease the rate and severity of anastomotic leakage, omentoplasty (OP) has been proposed by several authors on the basis of experimental and clinical studies. A prospective, randomized trial was designed to study the influence of omentoplasty on anastomotic leakage after colorectal resection.
  
  
  METHODS
  One hundred and twenty-six patients undergoing elective or emergency surgery for malignancy, benign tumor, diverticular disease and other were randomly assigned to omentoplasty (OP group) or not (NO group). The primary end point was the rate of clinical and radiological anastomotic leakage. Both groups were comparable in terms of demographic data, preoperative characteristics and intraoperative findings.
  
  
  RESULTS
  Eighteen patients (14.3%) had anastomotic leakage, 4 (6.4%) in the OP group and 14 (21.9%) in the NO group. Significant differences (P<0.05) between the two groups were also found in terms of repeat operation (3.2% vs. 14.1%) and deaths (3.2 vs. 7.8%). Other factors associated with anastomotic leakage were the distal site of anastomosis (<5 cm from anal verge) and the emergency.
  
  
  CONCLUSIONS
  Omental wrap, with its mechanical and biological properties, seems to be effective in lowering the rate and the severity of anastomotic leakage after colorectal surgery.
authors.affiliation: Department of Surgery, University of L'Aquila, Coppito, Italy. alagni@tin.it
authors.forename: A
authors.initials: A
authors.lastname: Agnifili
authors.forename: M
authors.initials: M
authors.lastname: Schietroma
authors.forename: A
authors.initials: A
authors.lastname: Carloni
authors.forename: S
authors.initials: S
authors.lastname: Mattucci
authors.forename: G
authors.initials: G
authors.lastname: Caterino
authors.forename: N J
authors.initials: NJ
authors.lastname: Lygidakis
authors.forename: F
authors.initials: F
authors.lastname: Carlei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000379:methods*; D003082:Colectomy / Q000009:adverse effects* / Q000379:methods; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009852:Omentum / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D013524:Surgical Flaps; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*; D016896:Treatment Outcome