Alternative, age- and viral load-related routes of nelfinavir resistance in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy.
To assess prevalence of nelfinavir resistance mutations in children receiving highly active antiretroviral therapy, sequencing of protease gene from plasma of 53 human immunodeficiency virus-infected children was performed. The prevalence of L90M was similar to that of D30N. There was a significant correlation with a higher viral load and lower age and the occurrence of L90M. These findings suggest differential molecular age- and viral load-related routes for nelfinavir resistance.
Machado
Elizabeth S
ES
Serviço de Doenças Infecciosas e Parasitárias, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, RJ, Brazil. emachado@biologia.ufrj.br
Lambert
John S
JS
Afonso
Adriana O
AO
Cunha
Silvia M
SM
Oliveira
Ricardo H
RH
Tanuri
Amilcar
A
Sill
Anne M
AM
Costa
Antonio J L
AJ
Soares
Marcelo A
MA
D000367:Age Factors; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009154:Mutation; D019888:Nelfinavir / Q000494:pharmacology / Q000627:therapeutic use*; D010597:Pharmacogenetics; D012307:Risk Factors; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D019562:Viral Load
D019888:Nelfinavir