title: Evaluation of dynamic studies of MR mammography for the diagnosis of intraductal lesions with nipple discharge.
abstract: OBJECTIVE
  We assessed the utility of dynamic magnetic resonance imaging (MRI) in differentiating benign from malignant lesions of the breast and then applied MRI to diagnose intraductal breast tumors with nipple discharge.
  
  
  METHODS
  Gadolinium (Gd)-enhanced MR mammography was performed on 74 patients with breast tumors and 8 patients with nipple discharge.
  
  
  RESULTS
  The steepest slopes of the contrast medium uptake (S slope) s from time-intensity curves were significantly different between malignant and benign lesions. At S slope threshold of 0.95% /second, malignancy was predicted with a sensitivity and specificity of 75% . Six of 8 cases with nipple discharge were successfully identified by MR ductography by injecting Gd-DTPA into discharging ducts. Among them, 2 non-invasive ductal carcinomas were differentiated from benign lesions by the S slope value.
  
  
  CONCLUSIONS
  Dynamic MR mammography is an useful modality for differentiating breast lesions and has potential for evaluating intraductal lesions with nipple discharge.
authors.affiliation: Second Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. tak55@med.yokohama-cu.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Momiyama
authors.forename: Yohei
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: Maho
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Tae
authors.initials: T
authors.lastname: Iwasawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D009558:Nipples / Q000473:pathology; D012680:Sensitivity and Specificity