Anti-TNF-alpha therapy for chronic inflammation: reconsidering pentoxifylline as an alternative to therapeutic protein drugs.
Pentoxifylline is a useful inhibitor of TNF-alpha production, thus resembling anti-inflammatory corticosteroids. The combination of pentoxifylline with Lyprinol is an effective treatment for chronic inflammation in rats, in this respect mimicking low dose prednisone with Lyprinol.
Whitehouse
M W
MW
Therapeutics Research Unit, Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia. whitehousemd@spin.net.au
D000818:Animals; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008055:Lipids / Q000627:therapeutic use; D010431:Pentoxifylline / Q000627:therapeutic use*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; C418997:lyprinol; D010431:Pentoxifylline