title: No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: a collaborative study by the Japanese Genetics Initiative for Drug Abuse.
abstract: In the central nervous system, tissue-plasminogen activator (t-PA)/plasmin system is involved in long-term synaptic plasticity and remodeling, and participates in rewarding effects of methamphetamine (MAP), by acutely regulating MAP-induced dopamine release in the nucleus accumbens. The aim of this study was to examine the relationships between the patients with MAP abusers/psychosis and the t-PA/plasminogen system genes. Subjects comprised 185 MAP abusers and 288 healthy controls. Four polymorphisms in the t-PA, plasminogen activator inhibitor, and plasminogen genes were examined in the present study. No significant differences were observed in each polymorphism between healthy controls and MAP abusers/psychosis. This study suggests that t-PA/plasminogen system is unlikely to be a major contributor to the substance abuse liability and/or the development of MAP psychosis.
authors.affiliation: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Iwata
authors.forename: T
authors.initials: T
authors.lastname: Inada
authors.forename: M
authors.initials: M
authors.lastname: Harano
authors.forename: T
authors.initials: T
authors.lastname: Komiyama
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Sekine
authors.forename: M
authors.initials: M
authors.lastname: Iyo
authors.forename: I
authors.initials: I
authors.lastname: Sora
authors.forename: H
authors.initials: H
authors.lastname: Ujike
authors.forename: N
authors.initials: N
authors.lastname: Ozaki
mesh_terms: D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016009:Chi-Square Distribution; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008694:Methamphetamine; D010959:Tissue Plasminogen Activator / Q000235:genetics*
chemical_list: D008694:Methamphetamine; D010959:Tissue Plasminogen Activator