MicroRNAs and the regulation of cell death.
Programmed cell death, or apoptosis, is ubiquitous, both during development and in the adult. Many components of the evolutionarily conserved machinery that brings about and regulates cell death have been identified, and all of these are proteins. However, in the past three years it has become clear that roughly 1% of predicted genes in animals encode small noncoding RNAs known as microRNAs, which regulate gene function. Here we review the recent identification of microRNA cell death regulators in Drosophila, hints that such regulators are also likely to exist in mammals, and more generally the approaches and tools that are now available to probe roles for noncoding RNAs in the control of cell death.
Xu
Peizhang
P
Division of Biology, MC156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
Guo
Ming
M
Hay
Bruce A
BA
D000818:Animals; D001483:Base Sequence; D016923:Cell Death; D016213:Cyclins / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008957:Models, Genetic; D015398:Signal Transduction
D016213:Cyclins; D029721:Drosophila Proteins; D035683:MicroRNAs; C471146:bantam microRNA, Drosophila