Selective lithiation of 4-(1H-1-pyrrolyl)pyridine. access to new electron-releasing ligands.
The first lithiation of 4-(1H-1-pyrrolyl)pyridine has been realized. The use of BuLi-containing lithium aggregates induced the selective pyridine ring functionalization by taking advantage of the electron-donor effect of the pyrrole nucleus. Opportune substituents were introduced alpha to the pyridine nitrogen leading to new electron-enriched pyridylphosphine, bipyridine, and terpyridine ligands.
Martineau
David
D
Synthèse Organométallique et Réactivité, UMR CNRS 7565, Université Henri Poincaré, Boulevard des Aiguillettes, 54506 Vandoeuvre-lès-Nancy, France.
Gros
Philippe
P
Fort
Yves
Y