title: Conservation laryngeal surgery for selected pyriform sinus cancer.
abstract: OBJECTIVE
  This study reports the treatment of a cohort of patients with pyriform sinus squamous cell carcinoma, using conservative surgery and radiotherapy.
  
  
  METHODS
  Thirty-four patients with pyriform sinus SCC were treated between 1986 and 2001, using partial laryngopharyngectomy with or without complementary radiotherapy. Seventy-six percent had stage III-IV lesions. Quality of life questionnaire and clinical examination were used for evaluation of laryngeal function.
  
  
  RESULTS
  Conservation surgery was undertaken. All patients underwent neck dissection. Two thirds of the patients received post-operative radiotherapy. Reconstruction was achieved by local muscular flap in 13 cases, radial forearm free flap in 18 and pectoralis major flap in three. Five-year overall and disease-specific survival rates were 50 and 65%, respectively. Successful laryngeal function preservation with local control was achieved in 80% of the patients.
  
  
  CONCLUSIONS
  Partial laryngopharyngectomy is a suitable treatment for early and selected advanced stage pyriform sinus carcinoma with a good functional and oncologic outcome.
authors.affiliation: Department of Head and Neck Surgery, Université Catholique de Louvain, St Luc University Hospital and Cancer Center, Brussels, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Plouin-Gaudon
authors.forename: B
authors.initials: B
authors.lastname: Lengelé
authors.forename: G
authors.initials: G
authors.lastname: Desuter
authors.forename: P
authors.initials: P
authors.lastname: Rombaux
authors.forename: S
authors.initials: S
authors.lastname: Ledeghen
authors.forename: V
authors.initials: V
authors.lastname: Grégoire
authors.forename: M
authors.initials: M
authors.lastname: Hamoir
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D015331:Cohort Studies; D003679:Deglutition / Q000502:physiology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D007830:Larynx / Q000503:physiopathology; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000637:transplantation; D010610:Pharyngeal Neoplasms / Q000601:surgery*; D010611:Pharyngectomy / Q000379:methods*; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D013060:Speech / Q000502:physiology; D013524:Surgical Flaps; D015996:Survival Rate; D016896:Treatment Outcome