Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome.
OBJECTIVE
To examine serum leptin concentrations in obese and lean patients with polycystic ovary syndrome (PCOS) to assess whether the changes in leptin levels are due to obesity or hormonal alterations.


METHODS
Controlled clinical study.


METHODS
Academic research environment.


METHODS
Obese and lean women with PCOS.


METHODS
Blood samples were collected before and after food consumption.


METHODS
Serum leptin and insulin levels.


RESULTS
Serum leptin concentrations were significantly correlated with body mass index (r = 0.649) and also with HOMA (r = 0.535). However, after controlling for body mass index in a partial correlation analysis, no significant correlation was found between serum leptin levels and HOMA or hyperinsulinemia. While lean patients with PCOS had a significant correlation between leptin concentrations and obesity parameters, they did not show any significant correlation with insulin resistance parameters.


CONCLUSIONS
Although leptin concentrations in women with PCOS correlate with insulin resistance/hyperinsulinemia, this is related only to obesity.
Erturk
Erdinc
E
Department of Endocrinology, Uludag University Hospital, Bursa, Turkey.
Kuru
Nesrin
N
Savci
Vahide
V
Tuncel
Ercan
E
Ersoy
Canan
C
Imamoglu
Sazi
S
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006706:Homeostasis; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications* / Q000473:pathology / Q000503:physiopathology
D020738:Leptin