title: Analysis of insulin-like growth factors and insulin-like growth factor I receptor expression in renal cell carcinoma.
abstract: The expression of insulin-like growth factors I (IGF-I) and II (IGF-II) and insulin-like growth factor-I receptor (IGF-IR) was studied in 137 clear cell, 23 chromophobe, and 20 papillary renal cell carcinomas (RCCs) using a tissue microarray technique. IGF-I immunoreactivity was detected in 110 (82.1%) of 134 clear cell, 8 (36%) of 22 chromophobe, and 3 (15%) of 20 papillary RCCs (P < .001). IGF-IR immunoreactivity was detected in 39 (29.5%) of 132 clear cell, 9 (41%) of 22 chromophobe, and 19 (95%) of 20 papillary RCCs (P < .001). In contrast, all tumors lacked IGF-II expression. Expression of IGF-I and IGF-IR was not related to tumor stage, grade, or prognosis. The IGF system is expressed differentially among different tumor types. The expression of IGF-I together with its receptor, IGF-IR, provides evidence for the existence of an autocrine-paracrine loop of tumor cell stimulation in RCC and makes this type of cancer a candidate for therapeutic strategies aimed to interfere with the IGF pathway.
authors.affiliation: Department of Urology, Division of Biomedical Engineering and, Computing, Medical University of Graz, Graz, Austria, Germany.
authors.forename: Luigi
authors.initials: L
authors.lastname: Schips
authors.forename: Richard
authors.initials: R
authors.lastname: Zigeuner
authors.forename: Manfred
authors.initials: M
authors.lastname: Ratschek
authors.forename: Peter
authors.initials: P
authors.lastname: Rehak
authors.forename: Josef
authors.initials: J
authors.lastname: Rüschoff
authors.forename: Cord
authors.initials: C
authors.lastname: Langner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D040081:Protein Array Analysis; D017451:Receptors, Somatomedin / Q000096:biosynthesis*; D013002:Somatomedins / Q000096:biosynthesis*
chemical_list: D017451:Receptors, Somatomedin; D013002:Somatomedins