title: Effects of two fluoridation measures on erosion progression in human enamel and dentine in situ.
abstract: The aim of the present study was to evaluate the effects of fluoride on erosive mineral loss in human enamel and dentine using a cyclic de- and remineralisation model in situ. The study was a three-treatment (5 days each) crossover design involving 4 (enamel) or 6 (dentine) healthy volunteers. Samples were recessed in palatal mouth appliances and worn day and night except during meals and were demineralised extraorally with 0.05 M citric acid (pH 2.3) for 6 x 5 min daily. Fluoridation was performed with toothpaste (SnF2/Olaflur; 0.14% F-) for 3 x 5 min daily (toothpaste fluoridation) or with toothpaste in combination with a mouthrinse (SnF2/Olaflur; 0.025% F-) for 3 x 5 min daily and with a gel (NaF/Olaflur, 1.25% F-) on days 1 and 3 instead of the toothpaste (intensive fluoridation). In the control group no fluoridation was performed. Mineral loss (microm) was determined with the use of longitudinal microradiography. In enamel, mineral loss was 40.7 +/- 15.1 microm in the control group, 18.3 +/- 12.4 microm after toothpaste fluoridation and 5.0 +/- 12.2 microm after intensive fluoridation. The respective values for dentine were 49.0 +/- 15.4, 35.0 +/- 15.5 and 19.8 +/- 12.0 microm. All differences were statistically significant (p < or = 0.001). The results indicate that intensive fluoridation is effective in preventing enamel and dentine from mineral loss even under severely erosive conditions.
authors.affiliation: Department of Conservative and Preventive Dentistry, Dental Clinic of the Justus Liebig University Giessen, Giessen, Germany. carolina.ganss@dentist.med.uni-giessen.de
authors.forename: C
authors.initials: C
authors.lastname: Ganss
authors.forename: J
authors.initials: J
authors.lastname: Klimek
authors.forename: V
authors.initials: V
authors.lastname: Brune
authors.forename: A
authors.initials: A
authors.lastname: Schürmann
mesh_terms: D000588:Amines / Q000008:administration & dosage; D000704:Analysis of Variance; D002327:Cariostatic Agents / Q000008:administration & dosage; D019343:Citric Acid / Q000494:pharmacology; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects; D003804:Dentin / Q000187:drug effects; D003959:Diamines / Q000008:administration & dosage; D004338:Drug Combinations; D005459:Fluorides / Q000008:administration & dosage; D006801:Humans; D008852:Microradiography; D009067:Mouthwashes; D012969:Sodium Fluoride / Q000008:administration & dosage*; D018709:Statistics, Nonparametric; D014002:Tin Fluorides / Q000008:administration & dosage*; D017001:Tooth Demineralization / Q000000981:diagnostic imaging / Q000517:prevention & control; D014077:Tooth Erosion / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods*; D014100:Toothpastes
chemical_list: D000588:Amines; D002327:Cariostatic Agents; D003959:Diamines; D004338:Drug Combinations; D009067:Mouthwashes; D014002:Tin Fluorides; D014100:Toothpastes; C059813:Meridol; D019343:Citric Acid; C495399:Olaflur; D012969:Sodium Fluoride; D005459:Fluorides