Transmission disequilibrium analysis of the GSN gene in a cohort of family trios with schizophrenia.
Apoptosis is thought to play a role in neuronal pathology in schizophrenia. Recently, the GSN gene was reported to have anti-apoptotic properties. In a genome-wide expression analysis on schizophrenia, GSN was also found to be significantly down-regulated in schizophrenia. All the hints suggest that GSN is a novel candidate gene in occurrence of schizophrenia. In this work, we genotyped 3 SNPs around the GSN locus in 493 sets of the Han Chinese trio sample using allele-specific PCR. A weak association or a marginally positive result was detected (0.05 for P-value of the overtransmitted haplotype and 0.02 for a global P-value).
Xi
Z R
ZR
Bio-X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, 1954 Huashan Road, Shanghai 200030, PR China.
Qin
W
W
Yang
Y F
YF
He
G
G
Gao
S H
SH
Ren
M S
MS
Peng
Y W
YW
Zhang
Z
Z
He
L
L
D000328:Adult; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D018260:Gelsolin / Q000235:genetics*; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology
D018260:Gelsolin