title: Arterial compliance in hypertension and heart failure.
abstract: The purpose of this paper is to investigate the relation between the presence and degree of arterial compliance impairment and, respectively, the clinical conditions of systemic hypertension and/or heart failure. We investigated 19 patients with hypertension, without heart failure (group A), 13 patients with hypertension and heart failure class NYHA II (group B), 10 patients with coronary heart disease and heart failure class NYHA II (group C) and 7 control patients without clinically relevant cardio-vascular diseases (group D). Compliance was evaluated with a Complior device, by measuring carotid femoral and carotid-radial pulse-wave velocities (PWV). Carotid-radial PWV did not differ significantly between the various groups (10.8 +/- 2, 10.6 +/- 0.9, 9.5 +/- 1.5 and 9.9 +/- 1.6 m/s, for groups A, B, C and D, respectively). Carotid-femoral PWV, in group A hypertensive p without heart failure, was 13.1 +/- 2.9 m/s, significantly higher as compared to group C p with coronary heart disease and heart failure (10.5 +/- 2.4 m/s, p = 0.02), as well as compared to group D controls (9.8 +/- 2.6, p = 0.02). Group B p, with heart failure associated to hypertension, had a carotid-femoral PWV of 13.5 +/- 3.9 m/s, similar to the one found in group A hypertensive p without heart failure. When comparing groups B and C p with heart failure, we noted that the carotid-femoral PWV was significantly (p = 0.04) increased in hypertensive p, as compared to those with coronary heart disease. In conclusion, the results of our study confirm the impairment of arterial compliance, in hypertensive patients. The carotid-femoral, but not the carotid-radial PWV, were useful for identifying impaired compliance in these patients. Heart failure, associated to hypertension, was not accompanied by a supplemental deterioration of arterial compliance. In fact, our study could not confirm the decrease of arterial compliance, in heart failure patients, as compared to controls. This study suggests the importance of hypertension, with its structural arterial wall changes, in the genesis of arterial compliance impairment.
authors.affiliation: Medical Clinic no. 1, Department of Cardiology, 3-5, Clinicilor Str., 3400 Cluj-Napoca, Romania. dolinic@umfcluj.ro
authors.forename: D
authors.initials: D
authors.lastname: Olinic
authors.forename: Maria
authors.initials: M
authors.lastname: Olinic
authors.forename: S
authors.initials: S
authors.lastname: Laza
authors.forename: Daniela
authors.initials: D
authors.lastname: Lenta
authors.forename: F
authors.initials: F
authors.lastname: Anton
authors.forename: C
authors.initials: C
authors.lastname: Albu
authors.forename: N
authors.initials: N
authors.lastname: Olinic
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000503:physiopathology*; D016022:Case-Control Studies; D003187:Compliance; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow; D017534:Radial Artery / Q000503:physiopathology*