Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex.
Using whole cell recordings, we studied excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) in feedforward (FF) and feedback (FB) circuits between areas V1 and LM (lateromedial) in developing mouse visual cortex. We found that in mice reared with normal visual experience, FF and FB synapses onto layer 2/3 pyramidal neurons develop equal but submaximal strengths whose EPSCs are increased by monocular lid suture. In contrast, the development and experience-dependence of FF- and FB-IPSCs is pathway-specific. The difference develops during the critical period by strengthening FF-IPSCs, while keeping FB-IPSC amplitudes constant. Monocular lid suture increases FB-IPSCs but does not affect FF-IPSCs.
Dong
Hongwei
H
Department of Anatomy and Neurobiology, Washington University School of Medicine, 8108 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Wang
Quanxin
Q
Valkova
Katia
K
Gonchar
Yuri
Y
Burkhalter
Andreas
A
D000818:Animals; D005246:Feedback / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition / Q000502:physiology*; D018408:Patch-Clamp Techniques; D011930:Reaction Time / Q000502:physiology; D012683:Sensory Deprivation / Q000502:physiology; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D015349:Vision, Monocular / Q000502:physiology; D014793:Visual Cortex / Q000254:growth & development* / Q000502:physiology; D014795:Visual Pathways / Q000254:growth & development / Q000502:physiology