title: Chromatographic behavior of pyrithiones.
abstract: Pyrithione biocides are currently viewed as a major prospect for the replacement of tributyltin antifoulants in ship paints. The chromatographic behavior of 1-hydroxy-2-pyridinethione (pyrithione, PT), bis(2-pyridinyl)disulfide 1,1'-dioxide (PT2), and the metal complexes zinc [Zn(PT)2], iron [Fe(PT)3] and copper [Cu(PT)2] pyrithione, were investigated by means of UV-vis spectroscopy, ESI-MSn, HPLC-DAD and HPLC-ESI-MSnD. This revealed transformations of the analytes, which affect the development of adequate methods for species or environmental analysis of pyrithiones. PT transforms into copper- or iron- containing complexes and/or the oxidation product PT2, depending on the type of the stationary phase used in chromatographic analysis. Speciation complicates direct chromatography of [Zn(PT)2] and [Fe(PT)3].
authors.affiliation: Center for Environmental Research and Environmental Technology, Department for Bioorganic Chemistry, University of Bremen, Bremen, Germany. c.doose@iu-bremen.de
authors.forename: Caren Anja
authors.initials: CA
authors.lastname: Doose
authors.forename: Maciej
authors.initials: M
authors.lastname: Szaleniec
authors.forename: Peter
authors.initials: P
authors.lastname: Behrend
authors.forename: Anja
authors.initials: A
authors.lastname: Müller
authors.forename: Bernd
authors.initials: B
authors.lastname: Jastorff
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D011725:Pyridines / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods*; D013871:Thiones
chemical_list: D011725:Pyridines; D013871:Thiones; C008704:pyrithione