title: Remote intrapulmonary spread of recurrent respiratory papillomatosis with malignant transformation.
abstract: Recurrent respiratory papillomatosis is the most common neoplasm of the larynx in childhood. Extension into lung parenchyma occurs in less than 1% of patients and has a low risk of malignant transformation. Treatment options for intrapulmonary spread have shown limited success. We describe a case of recurrent respiratory papillomatosis with extensive parenchymal involvement and adenosquamous carcinoma in a 14-year-old girl.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Sherri L
authors.initials: SL
authors.lastname: Katz
authors.forename: Prabodh
authors.initials: P
authors.lastname: Das
authors.forename: Bo-Yee
authors.initials: BY
authors.lastname: Ngan
authors.forename: David
authors.initials: D
authors.lastname: Manson
authors.forename: Alberto S
authors.initials: AS
authors.lastname: Pappo
authors.forename: Neil B
authors.initials: NB
authors.lastname: Sweezey
authors.forename: Melinda P
authors.initials: MP
authors.lastname: Solomon
mesh_terms: D000293:Adolescent; D001707:Biopsy, Needle; D018196:Carcinoma, Adenosquamous / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010212:Papilloma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed