Characterization of the preferred orientation of delta-mannitol crystallites in tablets.
The crystallographic texture, i.e. the preferred orientation of crystallites of delta-mannitol samples, has been experimentally determined by pole figure analysis. The pole figures were measured with an X-ray diffraction texture goniometer. It was found that already the uncompressed delta-mannitol powder sample was slightly texturized so that the (0 2 0) plane was parallel to the upper surface of the sample. The degree of preferred orientation was found to significantly increase when the powder was compressed to a tablet with the minimum (74MPa) compression pressure. Nevertheless, the direction of the texture remained parallel to the tablet surface. Maximum compression (740MPa) did not increase the degree of preferred orientation further. The compression time (0 or 60s) was not found to noticeably affect the strength or direction of the texture. The extent of the texture inside the tablet was determined with a tablet surface grinding experiment. The degree of preferred orientation was found to decrease under the surface while the orientation remained the same. The results were confirmed with orientation distribution function (ODF) calculations.
Koivisto
Mikko
M
University of Turku, Department of Physics, Vesilinnantie 5, Turku FI-20014, Finland. mikjuko@utu.fi
Virjonen
Tero
T
Heikkilä
Teemu
T
Lehto
Vesa-Pekka
VP
D003460:Crystallization; D008353:Mannitol / Q000032:analysis* / Q000737:chemistry*; D010316:Particle Size; D013608:Tablets, Enteric-Coated
D013608:Tablets, Enteric-Coated; D008353:Mannitol