title: Cerebral venous thrombosis is associated with major vessel disease in Behçet's syndrome.
abstract: OBJECTIVE
  To examine the association between the type of central nervous system (CNS) involvement (parenchymal disease and cerebral venous thrombosis (CVT)) and extra-cranial large vessel events, mainly venous thrombosis, in Behcet's syndrome (BS).
  
  
  METHODS
  Conventional venous angiograms, Doppler ultrasonography, computed tomography, and MR angiography were used to study 88 patients with BS, with (n = 88) and without (n = 80) CNS disease for the presence of major vessel disease.
  
  
  RESULTS
  Major vessel involvement among the male patients with and without CNS disease (21/73 (29%) v 18/80 (23%), respectively) showed no significant differences (p = 0.374). When patients with CNS disease were stratified according to the type of CNS involvement, 7/11 (64%) patients with CVT had major vessel disease compared with 15/77 (19%) patients with parenchymal disease (p = 0.004). The mean (SD) age of onset of CVT (23.1 (8.8) years) among the male patients was significantly earlier than among the men with parenchymal disease (32.0 (7.5); p = 0.002).
  
  
  CONCLUSIONS
  CVT in BS was strongly associated with peripheral major vessel disease and occurred earlier in the disease course than the parenchymal type of CNS disease. As superficial thrombophlebitis also occurs more frequently in patients with major vessel disease in BS, this may suggest a common pathogenic mechanism.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Meram School of Medicine, Selcuk University, Konya, Turkey. trecep@hotmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Tunc
authors.forename: S
authors.initials: S
authors.lastname: Saip
authors.forename: A
authors.initials: A
authors.lastname: Siva
authors.forename: H
authors.initials: H
authors.lastname: Yazici
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000473:pathology*