title: Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: comparison to 201Tl.
abstract: The goals of this investigation were to assess the accuracy of (18)F-fluorodihydrorotenone ((18)F-FDHR) as a new deposited myocardial flow tracer and to compare the results to those for (201)Tl.
  
  
  METHODS
  The kinetics of these flow tracers in 22 isolated, erythrocyte- and albumin-perfused rabbit hearts were evaluated over a flow range encountered in patients. The 2 flow tracers plus a vascular reference tracer ((131)I-albumin) were introduced as a bolus through a port just above the aortic cannula. Myocardial extraction, retention, washout, and uptake parameters were computed from the venous outflow curves with the multiple-indicator dilution technique and spectral analysis.
  
  
  RESULTS
  The mean +/- SD initial extraction fractions for (18)F-FDHR (0.85 +/- 0.07) and (201)Tl (0.87 +/- 0.05) were not significantly different, although the initial extraction fraction for (18)F-FDHR declined with flow (P < 0.0001), whereas the initial extraction fraction for (201)Tl did not. The washout of (201)Tl was faster (P < 0.001) and more affected by flow (P < 0.05) than was the washout of (18)F-FDHR. Except for the initial extraction fraction, (18)F-FDHR retention was higher (P < 0.001) and less affected by flow (P < 0.05) than was (201)Tl retention. Reflecting its superior retention, the net uptake of (18)F-FDHR was better correlated with flow than was that of (201)Tl at both 1 and 15 min after tracer introduction (P < 0.0001 for both comparisons).
  
  
  CONCLUSIONS
  The superior correlation of (18)F-FDHR uptake with flow indicates that it is a better flow tracer than (201)Tl in the isolated rabbit heart. Compared with the other currently available positron-emitting flow tracers ((82)Rb, (13)N-ammonia, and (15)O-water), (18)F-FDHR has the potential of providing excellent image resolution without the need for an on-site cyclotron.
authors.affiliation: Department of Nuclear Medicine and Functional Imaging, E.O. Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Marshall
authors.forename: Patricia
authors.initials: P
authors.lastname: Powers-Risius
authors.forename: Bryan W
authors.initials: BW
authors.lastname: Reutter
authors.forename: James P
authors.initials: JP
authors.lastname: O'Neil
authors.forename: Michael
authors.initials: M
authors.lastname: La Belle
authors.forename: Ronald H
authors.initials: RH
authors.lastname: Huesman
authors.forename: Henry F
authors.initials: HF
authors.lastname: VanBrocklin
mesh_terms: D000818:Animals; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000378:metabolism*; D007090:Image Interpretation, Computer-Assisted; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D049268:Positron-Emission Tomography; D011817:Rabbits; D011865:Radioisotope Dilution Technique; D012402:Rotenone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D013793:Thallium / Q000493:pharmacokinetics*
chemical_list: C494900:fluorodihydrorotenone; D012402:Rotenone; C027549:thallium chloride; D013793:Thallium