title: Lipodystrophy syndrome: the morphologic and metabolic effects of antiretroviral therapy in HIV infection.
abstract: Widespread use of highly active antiretroviral therapy (HAART) to manage HIV infection is now associated with the development of lipodystrophy syndrome. This syndrome is a combination of such morphologic and metabolic changes as hyperlipidemia, fat redistribution, and insulin resistance. Although many of the long-term effects of HAART have not been fully recognized, it is thought that lipodystrophy syndrome may now contribute to early-onset hypercholesterolemia, heart disease, and diabetes, and may have a negative psychological impact on the individual living with HIV infection.
authors.affiliation: Partnership Comprehensive Care Practice HIV Clinic, Drexel University, Philadelphia, PA, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Norris
authors.forename: H Michael
authors.initials: HM
authors.lastname: Dreher
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001823:Body Composition / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006949:Hyperlipidemias / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D007333:Insulin Resistance; D012307:Risk Factors