title: Management of meningococcemia.
abstract: Meningococcemia causes substantial morbidity and mortality worldwide, usually in the term of fulminant disease. This paper reviews the background, pathophysiology, clinical manifestations, and treatment of this entity, along with prevention measures and public health issues to be considered. The authors present updated information on breakthroughs in the understanding of genetic predisposition to invasive disease. The status of adjunctive treatment modalities such as monoclonal antibodies and activated protein C, and progress in conjugate vaccine development and implementation are also addressed.
authors.affiliation: Division of Pediatric Infectious Diseases, Children's Hospital of Orange County, 455 South Main Street, Orange, CA 92868, USA. jsingh@choc.org
authors.forename: Jasjit
authors.initials: J
authors.lastname: Singh
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Arrieta
mesh_terms: D016470:Bacteremia / Q000175:diagnosis* / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008589:Meningococcal Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D022401:Meningococcal Vaccines; D009345:Neisseria meningitidis / Q000302:isolation & purification
chemical_list: D022401:Meningococcal Vaccines