title: Two cases of fatal shock after transfusion of platelets contaminated by Staphylococcus aureus: role of superantigenic toxins.
abstract: We detected Staphylococcus aureus superantigenic toxins in the platelet infusion bags that had been used for 2 patients who subsequently developed transfusion-associated Staphylococcus aureus infection. Both patients, who were immunodeficient, developed manifestations of toxic shock syndrome and septic shock, and they died soon after the onset of infection.
authors.affiliation: Centre National de Référence des Staphylocoques, INSERM E0230, Institute Fédératif de Recherche 62, Lyon, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Perpoint
authors.forename: Gerard
authors.initials: G
authors.lastname: Lina
authors.forename: Claire
authors.initials: C
authors.lastname: Poyart
authors.forename: Bertille
authors.initials: B
authors.lastname: de Barbeyrac
authors.forename: Richard
authors.initials: R
authors.lastname: Traineau
authors.forename: Michel
authors.initials: M
authors.lastname: Jeanne
authors.forename: François
authors.initials: F
authors.lastname: Vandenesch
authors.forename: Jerome
authors.initials: J
authors.lastname: Etienne
mesh_terms: D000368:Aged; D000942:Antigens, Bacterial / Q000502:physiology; D004768:Enterotoxins / Q000502:physiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000009:adverse effects*; D012772:Shock, Septic / Q000209:etiology*; D013211:Staphylococcus aureus
chemical_list: D000942:Antigens, Bacterial; D004768:Enterotoxins; C031818:enterotoxin B, staphylococcal