title: Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents.
abstract: A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported.
authors.affiliation: Combio A/S, Vesterbrogade 188, DK-1800 Frederiksberg C, Denmark. pca@combio.biz
authors.forename: Patrizia
authors.initials: P
authors.lastname: Calí
authors.forename: Lars
authors.initials: L
authors.lastname: Naerum
authors.forename: Seema
authors.initials: S
authors.lastname: Mukhija
authors.forename: Anders
authors.initials: A
authors.lastname: Hjelmencrantz
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006877:Hydroxamic Acids; D007555:Isoxazoles; D000581:Amidohydrolases; C084507:peptide deformylase