Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada.
The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.
Tsang
Raymond S W
RS
National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2. rtsang@hc-sc.gc.ca
Lau
Allan K H
AK
Sill
Michelle L
ML
Halperin
Scott A
SA
Van Caeseele
Paul
P
Jamieson
Frances
F
Martin
Irene E
IE
D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D001886:Bordetella pertussis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D002170:Canada; D036781:Fimbriae Proteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010567:Pertussis Vaccine; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D012703:Serotyping; D010566:Virulence Factors, Bordetella / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D014917:Whooping Cough / Q000382:microbiology / Q000517:prevention & control
D000942:Antigens, Bacterial; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; C101542:fim3 protein, Bordetella; D036781:Fimbriae Proteins