title: Serum levels of soluble intercellular adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1 in Alzheimer's disease.
abstract: Serum soluble intercellular adhesion molecule-1 (s-ICAM-1) and soluble E-selectin (s-ELAM-1) were evaluated in 25 patients with Alzheimer's disease (AD), 54 patients with noninflammatory neurological diseases (NIND), and 15 control subjects. Patients with AD had a higher s-ICAM-1 level compared with the NIND patients and the control subjects (P< .001 and P< .04, respectively). The presence of high s-ICAM-1 values may be related to immunological processes involved in pathogenetic mechanisms of AD. The not statistically significant values of (s-ELAM-1), a glycoprotein considered an exclusive marker of endothelial activation, compared with the NIND patients and healthy subjects (P< .47 and P< .17, respectively), seem to suggest the neural rather than the endothelial s-ICAM origin in patients with AD.
authors.affiliation: Department of Neurology, Aeginition Hospital, Athens Medical School, Vass. Sophias av. 72-74, 11528 Athens, Greece. mrentzos@med.uoa.gr.
authors.forename: M
authors.initials: M
authors.lastname: Rentzos
authors.forename: M
authors.initials: M
authors.lastname: Michalopoulou
authors.forename: C
authors.initials: C
authors.lastname: Nikolaou
authors.forename: C
authors.initials: C
authors.lastname: Cambouri
authors.forename: A
authors.initials: A
authors.lastname: Rombos
authors.forename: A
authors.initials: A
authors.lastname: Dimitrakopoulos
authors.forename: E
authors.initials: E
authors.lastname: Kapaki
authors.forename: D
authors.initials: D
authors.lastname: Vassilopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012720:Severity of Illness Index
chemical_list: D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1