title: A very rare consequence of steroid therapy: ileal perforation in a patient with familial mediterranean fever.
abstract: Intestinal perforation rarely occurs in children with familial Mediterranean fever (FMF). When this does happen, it is the result of untreated intestinal obstruction caused by compression from peritoneal adhesions. Intestinal perforation is a well-known complication of steroid therapy in all ages. The duodenum is affected most frequently, but perforation may also occur in other parts of the small intestine and, very rarely, the colon. Intestinal wall changes that occur in chronic FMF may promote the harmful effects of steroids. Here we present an unexpected complication, ileal perforation, in an 8-year-old boy who was taking prednisolone for FMF-related arthritis.
authors.affiliation: Department of Pediatric Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.
authors.forename: A Ebru
authors.initials: AE
authors.lastname: Sakallioğlu
authors.forename: Iirfan Serdar
authors.initials: IS
authors.lastname: Arda
authors.forename: Sinasi
authors.initials: S
authors.lastname: Sevmiş
authors.forename: Esra
authors.initials: E
authors.lastname: Baskin
authors.forename: Banu
authors.initials: B
authors.lastname: Bilezikçi
authors.forename: Akgün
authors.initials: A
authors.lastname: Hiçsönmez
mesh_terms: D002648:Child; D010505:Familial Mediterranean Fever / Q000150:complications*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced*; D007416:Intestinal Perforation / Q000139:chemically induced*; D008297:Male; D011239:Prednisolone / Q000009:adverse effects*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone