Acute renal failure during the early postoperative period in adult living-related donor liver transplantation.
OBJECTIVE
Acute renal failure after liver transplantation can occur in some and is an important postoperative complication. Our goal is to clarify the risk factors of acute renal failure after living-related donor liver transplantation (LDLT).


METHODS
From March 1999 to August 2000, ten consecutive patients were investigated the changes of the systemic hemodynamics and the renal function. They were classified into Group A (Creatinine (Cre) was over 2.0 mg/dL) and B (Cre was below 2.0 mg/dL). Retrospective variables were examined with two groups A and B being compared.


RESULTS
In both groups, Cardiac Index (CI) was above standard levels. However, the CI levels in Group B were significantly higher than those in Group A (p=0.031). The early postoperative transaminase levels were significantly higher in Group A than in Group B (p=0.049) and graft liver volume/recipient body weight ratio was significantly smaller in Group A than in Group B (p=0.016).


CONCLUSIONS
Our study suggests that small-for-size graft or hypovolemia, resulting in the delay of the recovery of graft liver function, may be an important cause of acute renal failure during the early postoperative period in adult LDLT.
Yamamoto
Satoshi
S
Division of Digestive and General Surgery, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan.
Sato
Yoshinobu
Y
Ichida
Takafumi
T
Kurosaki
Isao
I
Nakatsuka
Hideki
H
Hatakeyama
Katsuyoshi
K
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy*; D005260:Female; D006084:Graft Rejection; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D015994:Incidence; D007677:Kidney Function Tests; D017093:Liver Failure / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011379:Prognosis; D006435:Renal Dialysis; D012189:Retrospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D016019:Survival Analysis