New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models.
Studies in animal models have revealed many surprises regarding the importance of key cell cycle regulators during animal development and homeostasis, underscoring the plasticity and redundancy of cell cycle circuitry within a whole-animal context. Moreover, checkpoint regulators, which are not essential for viability in yeast and cultured cells, play important roles in cell cycle control during development.
Humbert
Patrick O
PO
Cell cycle and cancer genetics laboratory, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.
Brumby
Anthony M
AM
Quinn
Leonie M
LM
Richardson
Helena E
HE
D000818:Animals; D002453:Cell Cycle; D002470:Cell Survival; D002940:Circadian Rhythm; D004261:DNA Replication; D016193:G1 Phase; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008938:Mitosis; D023421:Models, Animal