title: Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects.
abstract: Apolipoprotein M (apoM) is a recently characterized apolipoprotein that is exclusively expressed in the liver and kidney. In plasma it is present predominantly in high-density lipoprotein (HDL). The physiological function of apoM is not yet known. In the present study we investigated relationships between plasma apoM levels and leptin levels, body mass index (BMI), as well as fasting glucose and other lipid parameters in women with a wide range of BMI (18.9-57.1 kg/m(2), n = 51). In univariate analysis, apoM correlated significantly with leptin (r = 0.54, P < 0.001), BMI (r = 0,70, P < 0.001), fasting insulin (r = 0.33, P = 0.025), total cholesterol (r = -0.41, P = 0.016), and LDL-cholesterol (r = -0.39, P = 0.018). The correlations between apoM and cholesterol and between apoM and leptin remained significant after adjustment for the influence of BMI. Forward stepwise multiple regressions when leptin, BMI, insulin, and cholesterol were entered into a model as independent variables and apoM as the dependent variable, showed that cholesterol and leptin were independent predictors of circulating apoM. These two parameters yielded a value of r(2) = 0.28, thereby explaining approximately 30% of the variance in apoM. Hence, we show that apoM is positively related to leptin and negatively related to cholesterol in humans.
authors.affiliation: Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, S-221 85 Lund, Sweden.
authors.forename: Ning
authors.initials: N
authors.lastname: Xu
authors.forename: Peter
authors.initials: P
authors.lastname: Nilsson-Ehle
authors.forename: Bo
authors.initials: B
authors.lastname: Ahrén
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D000075243:Apolipoproteins M; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D054834:Lipocalins; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D012044:Regression Analysis
chemical_list: C400523:APOM protein, human; D001053:Apolipoproteins; D000075243:Apolipoproteins M; D020738:Leptin; D054834:Lipocalins; D002784:Cholesterol