New synthesis of PNA-3'DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras.
A new synthetic strategy to get the PNA-3'DNA linker with the monomethoxytrityl (Mmt) group as temporary protection of the backbone to be used for the synthesis of PNA/DNA chimeras was employed and a convenient strategy to obtain Mmt PNA monomers was developed. The synthetic strategies take advantage of the introduction of the acid-labile Mmt-protecting group in the first step.
Musumeci
Domenica
D
Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy.
Roviello
Giovanni N
GN
Valente
Margherita
M
Sapio
Roberto
R
Pedone
Carlo
C
Bucci
Enrico M
EM
D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D015394:Molecular Structure; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D011993:Recombinant Fusion Proteins / Q000138:chemical synthesis / Q000737:chemistry
D020135:Peptide Nucleic Acids; D011993:Recombinant Fusion Proteins; D004247:DNA