Different progression rates for deep white matter hyperintensities in elderly men and women.
The authors investigated the progression of white matter hyperintensities (WMHs) in a large population of elderly men and women. After 3 years of follow-up, women had accumulated approximately twice as much deep WMH (DWMH) as men. The progression of periventricular WMH was the same for men and women. Gender differences may affect the pathogenesis of DWMH, which in turn may result in different clinical consequences in women.
van den Heuvel
D M J
DM
Department of Radiology C2-S, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. D.M.J.van_den_Heuvel@lumc.nl
Admiraal-Behloul
F
F
ten Dam
V H
VH
Olofsen
H
H
Bollen
E L E M
EL
Murray
H M
HM
Blauw
G J
GJ
Westendorp
R G J
RG
de Craen
A J M
AJ
van Buchem
M A
MA
D000368:Aged; D001921:Brain / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D049292:Leukoaraiosis / Q000175:diagnosis* / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D012737:Sex Factors