Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study.
OBJECTIVE
To assess the effects of soybean-derived pinitol on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus.


METHODS
Randomized, double-blind, placebo-controlled, parallel-group trial.


METHODS
Pusan Paik Hospital, Pusan, Republic of Korea.


METHODS
A total of 30 patients with type II diabetes received an oral dose of 600 mg soybean-derived pinitol or placebo twice daily for 13 weeks.


RESULTS
Pinitol significantly decreased mean fasting plasma glucose, insulin, fructosamine, HbA1c, and the homeostatic model assessment insulin resistance index (HOMA-IR, P<0.001). Pinitol significantly decreased total cholesterol, LDL-cholesterol, the LDL/HDL-cholesterol ratio, and systolic and diastolic blood pressure and increased HDL-cholesterol (P<0.05).


CONCLUSIONS
These data suggest that soybean-derived pinitol may be beneficial in reducing cardiovascular risk in Korean type II diabetes.
Kim
J-I
JI
Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Institute of Basic Sciences, Inje University, Gimhae, Republic of Korea.
Kim
J C
JC
Kang
M-J
MJ
Lee
M-S
MS
Kim
J-J
JJ
Cha
I-J
IJ
D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013025:Glycine max / Q000737:chemistry*
D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D007294:Inositol; D007328:Insulin; C021730:pinitol