No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: a collaborative study by the Japanese Genetics Initiative for Drug Abuse.
In the central nervous system, tissue-plasminogen activator (t-PA)/plasmin system is involved in long-term synaptic plasticity and remodeling, and participates in rewarding effects of methamphetamine (MAP), by acutely regulating MAP-induced dopamine release in the nucleus accumbens. The aim of this study was to examine the relationships between the patients with MAP abusers/psychosis and the t-PA/plasminogen system genes. Subjects comprised 185 MAP abusers and 288 healthy controls. Four polymorphisms in the t-PA, plasminogen activator inhibitor, and plasminogen genes were examined in the present study. No significant differences were observed in each polymorphism between healthy controls and MAP abusers/psychosis. This study suggests that t-PA/plasminogen system is unlikely to be a major contributor to the substance abuse liability and/or the development of MAP psychosis.
Iwata
N
N
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Inada
T
T
Harano
M
M
Komiyama
T
T
Yamada
M
M
Sekine
Y
Y
Iyo
M
M
Sora
I
I
Ujike
H
H
Ozaki
N
N
D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016009:Chi-Square Distribution; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008694:Methamphetamine; D010959:Tissue Plasminogen Activator / Q000235:genetics*
D008694:Methamphetamine; D010959:Tissue Plasminogen Activator