title: Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia.
abstract: Aleukemic leukemia cutis is a rare condition characterized by the invasion of leukemic blasts into the skin before their appearance in the peripheral blood. Leukemia cutis usually occurs in patients with myeloid leukemia, especially the myelomonocytic and monocytic types of acute myeloblastic leukemia. We describe the case of a 62-year-old woman with aleukemic leukemia cutis who developed Philadelphia-positive acute leukemia 1 month after skin involvement. Leukemic cells expressed both myeloid and B-cell lineage surface markers, and monoclonal rearrangement of the immunoglobulin heavy chain was detected by Southern blot analysis. This report is the first of a case of aleukemic leukemia cutis preceding Philadelphia-positive biphenotypic leukemia.
authors.affiliation: Departments of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. masahiro.onozawa@nifty.ne.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Onozawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashino
authors.forename: Hiroe
authors.initials: H
authors.lastname: Kanamori
authors.forename: Koh
authors.initials: K
authors.lastname: Izumiyama
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Yonezumi
authors.forename: Koji
authors.initials: K
authors.lastname: Chiba
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuhara
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology; D001752:Blast Crisis; D019070:Cell Lineage; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D022423:Myeloid Cells / Q000473:pathology; D010641:Phenotype; D010677:Philadelphia Chromosome; D018805:Sepsis
chemical_list: D007143:Immunoglobulin Heavy Chains