Developmental origins and evolution of jaws: new interpretation of "maxillary" and "mandibular".
Cartilage of the vertebrate jaw is derived from cranial neural crest cells that migrate to the first pharyngeal arch and form a dorsal "maxillary" and a ventral "mandibular" condensation. It has been assumed that the former gives rise to palatoquadrate and the latter to Meckel's (mandibular) cartilage. In anamniotes, these condensations were thought to form the framework for the bones of the adult jaw and, in amniotes, appear to prefigure the maxillary and mandibular facial prominences. Here, we directly test the contributions of these neural crest condensations in axolotl and chick embryos, as representatives of anamniote and amniote vertebrate groups, using molecular and morphological markers in combination with vital dye labeling of late-migrating cranial neural crest cells. Surprisingly, we find that both palatoquadrate and Meckel's cartilage derive solely from the ventral "mandibular" condensation. In contrast, the dorsal "maxillary" condensation contributes to trabecular cartilage of the neurocranium and forms part of the frontonasal process but does not contribute to jaw joints as previously assumed. These studies reveal the morphogenetic processes by which cranial neural crest cells within the first arch build the primordia for jaw cartilages and anterior cranium.
Cerny
Robert
R
Department of Zoology, Charles University, 128 44 Prague, Czech Republic.
Lwigale
Peter
P
Ericsson
Rolf
R
Meulemans
Daniel
D
Epperlein
Hans-Henning
HH
Bronner-Fraser
Marianne
M
D000557:Ambystoma / Q000196:embryology*; D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning; D002356:Cartilage / Q000196:embryology / Q000648:ultrastructure; D002642:Chick Embryo; D004396:Coloring Agents; D004625:Embryo, Nonmammalian; D016650:Fluorescein-5-isothiocyanate; D049452:Green Fluorescent Proteins; D017403:In Situ Hybridization; D008334:Mandible / Q000196:embryology* / Q000254:growth & development; D008437:Maxilla / Q000196:embryology* / Q000254:growth & development; D008954:Models, Biological; D009024:Morphogenesis; D009432:Neural Crest / Q000166:cytology; D013194:Staining and Labeling
D004396:Coloring Agents; D049452:Green Fluorescent Proteins; D016650:Fluorescein-5-isothiocyanate