[Immunomodulatory effects of intravenous immunoglobulins].
Intravenous immunoglobulins (IVIg) are therapeutic preparations of normal human IgG obtained from pools of more than 1000 healthy blood donors. They are currently used in the treatment of a wide range of auto-immune diseases, whether associated with auto-antibodies or auto-reactive T lymphocytes, as well as in the treatment of systemic inflammatory diseases. Several mechanisms of action have been identified during the last 20 years, including: (i) modulation of Fc receptors expression on leukocytes and endothelial cells; (ii) interaction with complement proteins; (iii) modulation of cytokines and chemokines synthesis and release; (iv) modulation of cell proliferation and apoptosis; (v) remyelinisation; (vi) neutralisation of circulating autoantibodies; (vii) selection of repertoires of B and T lymphocytes; (viii) interaction with other cell-surface molecules on lymphocytes and monocytes; (ix) corticosteroid sparing. These mechanisms of action are multiple and often intricate. However, they are still little known and further investigations are warranted.
Guilpain
Philippe
P
Service de médecine interne, Hôpital Cochin, Assistance publique-Hôpitaux de Paris et Université Paris V, Paris.
Chanseaud
Youri
Y
Tamby
Mathieu C
MC
Larroche
Claire
C
Guillevin
Loïc
L
Kaveri
Srini V
SV
Kazatchkine
Michel D
MD
Mouthon
Luc
L
D017209:Apoptosis; D001327:Autoimmune Diseases / Q000188:drug therapy*; D002450:Cell Communication; D002455:Cell Division; D018925:Chemokines / Q000096:biosynthesis / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D016756:Immunoglobulins, Intravenous / Q000276:immunology* / Q000494:pharmacology*; D007962:Leukocytes; D008214:Lymphocytes / Q000502:physiology*; D011961:Receptors, Fc / Q000096:biosynthesis
D018925:Chemokines; D016207:Cytokines; D016756:Immunoglobulins, Intravenous; D011961:Receptors, Fc