Pregnancy in essential thrombocythaemia: experience with 40 pregnancies.
In this study, the course of 40 pregnancies in 16 women with essential thrombocythaemia (ET) was analysed retrospectively. Of the pregnancies, 45% were complicated, 55% uncomplicated, and 62% resulted in live birth. The most common complication was spontaneous abortion during the first trimester seen in 33% of all pregnancies and comprising 72% of all complications. Two intrauterine foetal deaths occurred at weeks 22 and 28. Three pregnancies were complicated by eclampsia or pre-eclampsia. Nine of 16 women with 29 pregnancies had at least one complicated pregnancy. In seven of 16 women, all 11 pregnancies were uneventful. The non-pregnancy-related symptoms of ET or the platelet count before conception or during pregnancy did not correlate with the risk of pregnancy complications. Treatment with low-dose acetylsalicylic acid (ASA) alone during pregnancy or platelet-lowering drugs before or during pregnancy reduced the risk of complications.
Niittyvuopio
Riitta
R
Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Juvonen
Eeva
E
Kaaja
Risto
R
Oksanen
Kalevi
K
Hallman
Heikki
H
Timonen
Timo
T
Ruutu
Tapani
T
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D004461:Eclampsia / Q000453:epidemiology; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005387:Finland / Q000453:epidemiology; D006801:Humans; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D013920:Thrombocythemia, Essential / Q000188:drug therapy / Q000453:epidemiology*
D000925:Anticoagulants; D001241:Aspirin