Study of gelling behavior of poly(vinyl alcohol)-methacrylate for potential utilizations in tissue replacement and drug delivery.
The need of innovative, multifunctional biomaterials for the partial or complete tissue replacement is the driving force for the search of improvements of the performances of the available materials and in the formulation of new ones. Addressing the focus to vitreous substitution, we have explored the possibility of using injectable aqueous solutions of poly(vinyl alcohol), PVA, derivatives able to form hydrogels in the ocular cavity upon UV-vis irradiation with visible light. In particular, we describe the features of hydrogels from methacrylate grafted PVA, PVA-MA, in terms of structural characteristics, degradation processes, release of low- and high- molecular weight molecules, and in vitro gelation kinetics. The mechanical properties, drug delivery tests, and rheology tests suggest that PVA-MA derivatives have the potential to become a useful material for vitreous substitution.
Cavalieri
Francesca
F
Dipartimento di Scienze e Tecnologie Chimiche and INFM Sezione B, Università di Roma Tor Vergata, via della Ricerca Scientifica 00133 Rome, Italy.
Miano
Fausto
F
D'Antona
Paolo
P
Paradossi
Gaio
G
D001672:Biocompatible Materials; D004058:Diffusion; D016503:Drug Delivery Systems; D005782:Gels / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D007700:Kinetics; D008027:Light; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011522:Protons; D012212:Rheology; D013696:Temperature; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*; D014466:Ultraviolet Rays
D001672:Biocompatible Materials; D005782:Gels; D020100:Hydrogels; D046911:Macromolecular Substances; D008689:Methacrylates; D011108:Polymers; D011522:Protons; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011142:Polyvinyl Alcohol