title: Association between fertility drugs and gynecologic cancers, breast cancer, and childhood cancers.
abstract: Ovulation-inducing drugs have been widely used for various types of infertility since the beginning of 1960s and their use increases day by day parallel to the success achieved in fertility treatment. However, the researches performed in the last two decades have begun to discuss about the safety of these drugs and the risks associated with their use. Especially, the potential neoplastic effects of these drugs are increasingly questioned. The studies have discussed whether there is an association between the exposure to ovulation-inducing drugs and the incidence of various cancers. Moreover, several studies have been performed to reveal whether there is an increased risk of childhood cancers in children conceived after fertility treatment. The point we reached through the available data is that the risk of breast, uterine and invasive ovarian cancers is not increased, but the risk of borderline ovarian tumors might increase after such a therapy. The risk of cancer has been found similar for children conceived after fertility treatment and those conceived naturally. It should also be kept in mind that cancers are overdiagnosed in infertile women population because of the close medical surveillance, which may also contribute to the early detection of cancers. Although it is still early to state the last words on this topic, the possible association should be addressed when obtaining an informed consent before starting treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Hacettepe, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ayhan
authors.forename: Mehmet Coskun
authors.initials: MC
authors.lastname: Salman
authors.forename: Husnu
authors.initials: H
authors.lastname: Celik
authors.forename: Polat
authors.initials: P
authors.lastname: Dursun
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ozyuncu
authors.forename: Murat
authors.initials: M
authors.lastname: Gultekin
mesh_terms: D001943:Breast Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D002648:Child; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000188:drug therapy; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D005300:Fertility Agents, Female