title: On the reaction of 1-oxa-4-thiaspiro[4.5]decan-7-one with PhLi. A reinvestigation.
abstract: Two diastereomeric alcohols are formed from the reaction of 1-oxa-4-thiaspiro[4.5]decan-7-one with PhLi as against the single diastereomer reported earlier. The diastereoselectivity achieved from PhMgBr is significantly higher than with PhLi. The use of Et(2)O/hexane = 2:1 as the solvent for the reaction with PhMgBr offered the highest (14:1) diastereocontrol.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kanpur-208 016, India. vijendra@iitk.ac.in
authors.forename: Veejendra K
authors.initials: VK
authors.lastname: Yadav
authors.forename: Govindaraji
authors.initials: G
authors.lastname: Senthil
authors.forename: Latika
authors.initials: L
authors.lastname: Singh
authors.forename: Masood
authors.initials: M
authors.lastname: Parvez