title: Development of radioligands for in vivo imaging of GABA(A)-benzodiazepine receptors.
abstract: Changes in the biochemical integrity and function of the GABA(A)-benzodiazepine receptor (BZR) complex have been implicated in various neurological and psychiatric disorders. The development of specific radioligands for the GABA(A)-BZR have not only contributed to the elucidation of the receptor's biochemical functions, but also provided a means by which these changes are correlated to disease states when studied with the functional imaging modalities of positron emission tomography (PET) and single photon emission computed tomography (SPECT).
authors.affiliation: Radiopharmaceuticals Division R&D, Australian Nuclear Science and Technology Organisation, Private Mail Bag 1, Menai NSW 2234, Sydney, Australia. akx@ansto.gov.au
authors.forename: Andrew
authors.initials: A
authors.lastname: Katsifis
authors.forename: Michael
authors.initials: M
authors.lastname: Kassiou
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism* / Q000493:pharmacokinetics; D002493:Central Nervous System Diseases / Q000175:diagnosis; D004355:Drug Stability; D006801:Humans; D007553:Isotope Labeling; D008024:Ligands; D015394:Molecular Structure; D011868:Radioisotopes; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D014055:Tomography, Emission-Computed / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D008024:Ligands; D011868:Radioisotopes; D011963:Receptors, GABA-A; D001569:Benzodiazepines