title: Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana.
abstract: We present a novel graphical Gaussian modeling approach for reverse engineering of genetic regulatory networks with many genes and few observations. When applying our approach to infer a gene network for isoprenoid biosynthesis in Arabidopsis thaliana, we detect modules of closely connected genes and candidate genes for possible cross-talk between the isoprenoid pathways. Genes of downstream pathways also fit well into the network. We evaluate our approach in a simulation study and using the yeast galactose network.
authors.affiliation: Reverse Engineering Group, Swiss Federal Institute of Technology (ETH), Zurich. awille@inf.ethz.ch
authors.forename: Anja
authors.initials: A
authors.lastname: Wille
authors.forename: Philip
authors.initials: P
authors.lastname: Zimmermann
authors.forename: Eva
authors.initials: E
authors.lastname: Vranová
authors.forename: Andreas
authors.initials: A
authors.lastname: Fürholz
authors.forename: Oliver
authors.initials: O
authors.lastname: Laule
authors.forename: Stefan
authors.initials: S
authors.lastname: Bleuler
authors.forename: Lars
authors.initials: L
authors.lastname: Hennig
authors.forename: Amela
authors.initials: A
authors.lastname: Prelic
authors.forename: Peter
authors.initials: P
authors.lastname: von Rohr
authors.forename: Lothar
authors.initials: L
authors.lastname: Thiele
authors.forename: Eckart
authors.initials: E
authors.lastname: Zitzler
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Gruissem
authors.forename: Peter
authors.initials: P
authors.lastname: Bühlmann
mesh_terms: D017360:Arabidopsis / Q000235:genetics*; D003196:Computer Graphics / Q000706:statistics & numerical data*; D003198:Computer Simulation / Q000706:statistics & numerical data; D005690:Galactose / Q000378:metabolism; D005800:Genes, Fungal / Q000235:genetics; D017343:Genes, Plant / Q000235:genetics* / Q000502:physiology; D008957:Models, Genetic; D016011:Normal Distribution; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D013729:Terpenes / Q000378:metabolism*
chemical_list: D013729:Terpenes; D005690:Galactose