Sheathless electrospray ionization interfaces for capillary electrophoresis-mass spectrometric detection advantages and limitations.
A review of sheathless interfaces for capillary electrophoresis (CE)-mass spectrometry (MS) is presented. The review discusses the on-line CE-MS system requirements, advantages and weaknesses of current sheathless interface designs for CE-electrospray ionization MS, and comparison between sheath flow and sheathless interfaces. The advantages and limitations of three sheathless designs are discussed and commented upon, these include single-capillary, two-capillary and three-piece designs.
Issaq
Haleem J
HJ
Laboratory of Proteomics and Analytical Technologies, SAIC Frederick Inc., National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 20702, USA. issaqh@mail.ncifcrf.gov
Janini
George M
GM
Chan
King C
KC
Veenstra
Timothy D
TD
D019075:Electrophoresis, Capillary / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*