title: [A renoprotective effect of enalapril in chronic transplantation nephropathy].
abstract: OBJECTIVE
  To study safety and efficacy of ACE inhibitor enalapril in chronic transplantation nephropathy (CTN) as well as nephroprotective efficacy of this drug in various clinical variants of CTN.
  
  
  METHODS
  A retrospective study covered 220 recipients with CRF. The patients were divided into the study group (n = 103) and the control group (n = 117). The study group was given ACE inhibitor enalapril the efficacy of which was assessed by arterial pressure (systolic, diastolic, mean) dynamics, 24 h proteinuria and the rate of CTN progression. This rate was suggested by probability of plasm creatinin doubling (Kaplan-Meier technique).
  
  
  RESULTS
  Enalapril significantly inhibited CTN progression running with minimal or marked proteinuria, had a pronounced hypotensive effect, promoted stabilization of minimal proteinuria (in CTN with minimal proteinuria) or reduction of protein excretion (in a proteinuric variant of CTN).
  
  
  CONCLUSIONS
  Use of enalapril in CTN in a daily dose 10 mg maximum is safe and can be used for inhibition of CTN progression.
authors.forename: N A
authors.initials: NA
authors.lastname: Tomilina
authors.forename: A R
authors.initials: AR
authors.lastname: Bagdasarian
authors.forename: E S
authors.initials: ES
authors.lastname: Stoliarevich
authors.forename: A V
authors.initials: AV
authors.lastname: Sukhanov
authors.forename: N D
authors.initials: ND
authors.lastname: Fedorova
authors.forename: I M
authors.initials: IM
authors.lastname: Il'inskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Tyrin
authors.forename: A V
authors.initials: AV
authors.lastname: Frolov
mesh_terms: D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004656:Enalapril / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000959:Antihypertensive Agents; D004656:Enalapril