[Experimental study on preventing postoperative posterior urethra scar in response to Tablet Fu Kang].
OBJECTIVE
To find an effective measurement to prevent and decrease the posterior urethral scar stricture.


METHODS
Twenty New Zealand rabbits were chosen. All the rabbits were made posterior urethra disruption model, and at the same time, the urethra anastomosis operation was performed. Twenty rabbits were divided into two groups after operation at random. One group was treated by Tablet Fu Kang (experimental group), another group was treated by NS (control group). All the rabbits were killed three weeks later, the urethra anastomotic stoma tissue was chosen and stained with Masson. All the figures of slides were inputted into figure analytic system.


RESULTS
There were little collagenous fiber, sparsely and arranged in good order in scar tissue of urethra anastomotic stoma in experimental group. The area of collagenous fibers was 117.11 +/- 10.17 microm2 in three visual fields. There were many collagenous fibers, densely,and arranged in disorder in scar tissue of urethra anastomotic stoma in control group, the relative area was 136.43 +/- 15.85 microm2. There was statistic significance when comparing the area of collagenous fiber in two groups (P < 0.05).


CONCLUSIONS
Tablet Fu Kang could restrain the hyperplasia of fibroblast in the process of wound healing of rabbit smooth muscle in urethra.
Mo
Jiacong
J
The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080.
Wang
Shengyi
S
D000714:Anastomosis, Surgical; D000818:Animals; D019661:Apiaceae / Q000737:chemistry; D002921:Cicatrix / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000648:ultrastructure; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D013607:Tablets; D014521:Urethra / Q000473:pathology* / Q000601:surgery; D014525:Urethral Stricture / Q000473:pathology / Q000517:prevention & control*; D014945:Wound Healing / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D013607:Tablets; D003094:Collagen