Genetic confirmation of quinine-resistant Plasmodium falciparum malaria followed by postmalaria neurological syndrome in a traveler from Mozambique.
A case of quinine-resistant Plasmodium falciparum malaria, followed by a postmalaria neurological syndrome and a recurrence episode, is described. Genetic characterization of the P. falciparum isolate obtained by analysis of msp1 and msp2 amplicons revealed the coexistence of two genotypes causing the first malaria episode and the presence of a unique isolate responsible for the recurrence.
Palmieri
Fabrizio
F
Istituto Nazionale per le Malattie Infettive Lazzo Spallanzani, Rome, Italy.
Petrosillo
Nicola
N
Paglia
Maria Grazia
MG
Conte
Aristide
A
Goletti
Delia
D
Pucillo
Leopoldo Paolo
LP
Menegon
Michela
M
Sannella
Anna
A
Severini
Carlo
C
Majori
Giancarlo
G
D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D016779:Malaria, Cerebral / Q000150:complications / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000150:complications / Q000469:parasitology*; D008297:Male; D009073:Mozambique; D010963:Plasmodium falciparum / Q000145:classification* / Q000187:drug effects* / Q000235:genetics; D011803:Quinine / Q000494:pharmacology*; D012008:Recurrence; D014195:Travel
D000962:Antimalarials; D011803:Quinine; D007770:L-Lactate Dehydrogenase