Expression of JNK interacting protein JIP-1 is down-regulated in liver from mouse embryos with a disrupted insulin-like growth factor II gene.
JNK interacting Protein 1 (JIP-1) is a pivotal scaffolding protein in the JNK signalling pathway. Its expression pattern in murine tissue indicates that JIP-1 has a role in the regulation of different cellular events. By examining the JIP-1 expression in transgenic mice that were heterozygous for a functional insulin-like growth factor II (igf-2) gene, it was possible to show that an abrogated igf-2 expression was followed by a decreased transcription of the JIP-1 gene. This pattern was consistent through different litters, which suggests that the up- or down-regulation of JIP-1 may well be part of the intracellular mediation of IGF II induced messages.
Rohbe
Lisa
L
Department of Pathology, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden.
Larsson
Mia
M
Rising
Anna
A
Grip
Stefan
S
Burns
Jason
J
Engström
Wilhelm
W
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D015536:Down-Regulation / Q000235:genetics*; D004622:Embryo, Mammalian / Q000196:embryology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006579:Heterozygote; D007335:Insulin-Like Growth Factor II / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000196:embryology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D016133:Polymerase Chain Reaction; D012313:RNA / Q000235:genetics; D014158:Transcription, Genetic
D048868:Adaptor Proteins, Signal Transducing; C490665:Mapk8ip protein, mouse; D012313:RNA; D007335:Insulin-Like Growth Factor II