title: Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada.
abstract: The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.
authors.affiliation: National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2. rtsang@hc-sc.gc.ca
authors.forename: Raymond S W
authors.initials: RS
authors.lastname: Tsang
authors.forename: Allan K H
authors.initials: AK
authors.lastname: Lau
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Sill
authors.forename: Scott A
authors.initials: SA
authors.lastname: Halperin
authors.forename: Paul
authors.initials: P
authors.lastname: Van Caeseele
authors.forename: Frances
authors.initials: F
authors.lastname: Jamieson
authors.forename: Irene E
authors.initials: IE
authors.lastname: Martin
mesh_terms: D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D001886:Bordetella pertussis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D002170:Canada; D036781:Fimbriae Proteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010567:Pertussis Vaccine; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D012703:Serotyping; D010566:Virulence Factors, Bordetella / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D014917:Whooping Cough / Q000382:microbiology / Q000517:prevention & control
chemical_list: D000942:Antigens, Bacterial; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; C101542:fim3 protein, Bordetella; D036781:Fimbriae Proteins