Tregs and transplantation tolerance.
The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes specific unresponsiveness to donor alloantigens. This review outlines our current understanding of the Treg subsets that contribute to allotolerance and the mechanisms by which these cells exert their effects as well as their potential for therapy.
Walsh
Patrick T
PT
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA.
Taylor
Devon K
DK
Turka
Laurence A
LA
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism; D008954:Models, Biological; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D016212:Transforming Growth Factor beta / Q000276:immunology / Q000378:metabolism; D014181:Transplantation Immunology; D023001:Transplantation Tolerance / Q000276:immunology*
D016212:Transforming Growth Factor beta; D016753:Interleukin-10