title: Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea.
abstract: Mouse thymus-leukemia antigens (TL) are aberrantly expressed on T lymphomas in C57BL/6 (B6) and C3H/He (C3H) mice, while they are not expressed on normal T lymphocytes in these strains. When N-butyl-N-nitrosourea (NBU), a chemical carcinogen, was administered orally to B6 and C3H strains, lymphoma development was slower than in T3(b)-TL gene-transduced counterpart strains expressing TL ubiquitously as self-antigens, suggesting that anti-TL immunity may play a protective role. In addition, the development of lymphomas was slightly slower in C3H than in B6, which seems to be in accordance with the results of skin graft experiments indicating that both cellular and humoral immunities against TL were stronger in C3H than B6 mice. The interesting finding that B lymphomas derived from a T3(b)-TL transgenic strain (C3H background) expressing a very high level of TL were rejected in C3H, but not in H-2K(b) transgenic mice (C3H background), raises the possibility that TL-specific effector T cell populations are eliminated and/or energized to a certain extent by interacting with H-2K(b) molecules.
authors.affiliation: Division of Immunology, Aichi Cancer Center Research Institute, Nagoya 464-8681. ktsujimu@aichi-cc.jp
authors.forename: Kunio
authors.initials: K
authors.lastname: Tsujimura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Obata
authors.forename: Yasue
authors.initials: Y
authors.lastname: Matsudaira
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ozeki
authors.forename: Osamu
authors.initials: O
authors.lastname: Taguchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Nishida
authors.forename: Yuko
authors.initials: Y
authors.lastname: Okanami
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Akatsuka
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kuzushima
authors.forename: Toshitada
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000096:biosynthesis; D002273:Carcinogens; D006084:Graft Rejection; D006183:H-2 Antigens / Q000276:immunology; D008223:Lymphoma / Q000139:chemically induced / Q000517:prevention & control*; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000401:mortality; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009607:Nitrosourea Compounds; D016038:Skin Transplantation / Q000276:immunology; D013045:Species Specificity
chemical_list: D000951:Antigens, Neoplasm; D002273:Carcinogens; D006183:H-2 Antigens; D008562:Membrane Glycoproteins; D009607:Nitrosourea Compounds; C028388:thymus-leukemia antigens; C002738:N-nitrosobutylurea