Long-term effects of tibolone on mammographic density.
OBJECTIVE
To investigate the long-term effect of tibolone on mammographic density.


METHODS
Open-label, nonrandomized study.


METHODS
Academic research environment.


METHODS
Postmenopausal women.


METHODS
Tibolone was administered orally, mammograms were performed annually.


METHODS
Mammographic density according to the Wolfe classification, performed by two independent radiologists, both of whom were blinded to treatment group.


RESULTS
No statistically significant differences were found between the two groups in baseline demographic data. There were no statistically significant differences in mammographic density between the control and active groups at baseline or at 10 years.


CONCLUSIONS
This pilot study shows that tibolone does not adversely alter the mammographic density of the breasts over 10 years of treatment.
Bruce
Deborah
D
Menopause Research Unit, Guy's Hospital, London, United Kingdom. debs_bruce@hotmail.com
Robinson
Jillian
J
McWilliams
Sarah
S
Reddy
Mamatha
M
Fentiman
Ian
I
Rymer
Janice
J
D000284:Administration, Oral; D001940:Breast / Q000187:drug effects*; D016022:Case-Control Studies; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008327:Mammography; D008875:Middle Aged; D009652:Norpregnenes / Q000008:administration & dosage / Q000627:therapeutic use*; D010024:Osteoporosis / Q000517:prevention & control; D010865:Pilot Projects; D016037:Single-Blind Method
D009652:Norpregnenes; C027385:tibolone