PARK11 is not linked with Parkinson's disease in European families.
Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.
Prestel
Jürgen
J
Hertie-Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler Str. 3, 72076 Tuebingen, Germany.
Sharma
Manu
M
Leitner
Petra
P
Zimprich
Alexander
A
Vaughan
Jenny R
JR
Dürr
Alexandra
A
Bonifati
Vincenzo
V
De Michele
Giuseppe
G
Hanagasi
Hasmet A
HA
Farrer
Matthew
M
Hofer
Anne
A
Asmus
Friedrich
F
Volpe
Giampiero
G
Meco
Giuseppe
G
Brice
Alexis
A
Wood
Nicholas W
NW
Müller-Myhsok
Bertram
B
Gasser
Thomas
T
D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005060:Europe; D006801:Humans; D008126:Lod Score; D010300:Parkinson Disease / Q000235:genetics*; D044465:White People