Pathophysiology of trigeminal neuralgia: new evidence from a trigeminal ganglion intraoperative microneurographic recording. Case report.
The origin of trigeminal neuralgia (TN) appears to be vascular compression of the trigeminal nerve at the root entry zone; however, the physiological mechanism of this disorder remains uncertain. The authors obtained intraoperative microneurographic recordings from trigeminal ganglion neurons in a patient with TN immediately before percutaneous radiofrequency-induced gangliolysis. Their findings are consistent with the idea that the pain of TN is generated, at least in part, by an abnormal discharge within the peripheral nervous system.
Burchiel
Kim J
KJ
Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon 97239-3098, USA.
Baumann
Thomas K
TK
D000200:Action Potentials / Q000502:physiology*; D000368:Aged; D017115:Catheter Ablation; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative; D009474:Neurons / Q000502:physiology*; D010812:Physical Stimulation; D012668:Trigeminal Ganglion / Q000503:physiopathology*; D014277:Trigeminal Neuralgia / Q000503:physiopathology* / Q000601:surgery