title: Asymmetric iodolactamization induced by chiral oxazolidine auxiliary.
abstract: Asymmetric iodolactamization reactions of unsaturated amides with oxazolidines as the chiral auxiliaries were investigated. With (4S)-4-((2R)-2-butyl)-2,2-dimethyloxazolidine as the auxiliary and LiH as the base, a number of unsaturated amides underwent iodolactamization smoothly to afford the corresponding gamma- and delta-lactams in 30-98% yield with de values up to 97%.
authors.affiliation: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Shen
authors.forename: Chaozhong
authors.initials: C
authors.lastname: Li