Autosomal dominant flat umbilicus.
We describe a Chinese family among whom five members in three generations had a flat umbilicus with vertical and male to male transmission indicative of autosomal dominant inheritance. Except the proband, who also had Tetralogy of Fallot, other affected members had a flat umbilicus as an isolated anomaly. Autosomal dominant transmission of isolated flat umbilicus has not been reported previously.
Leung
Alexander K C
AK
Department of Pediatrics, the University of Calgary, Alberta Children's Hospital, Calgary, Alberta T2M 0H5, Canada. aleung@ucalgary.ca
McLeod
D Ross
DR
D000293:Adolescent; D002648:Child; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014472:Umbilicus / Q000002:abnormalities*