[Therapeutic effects of a low molecular weight peptide from cattle spleen on masugi nephritis in rats].
OBJECTIVE
To investigate the therapeutic effects of a low molecular weight peptide KZ-36 from cattle spleen on masugi nephritis in rats.


METHODS
The rabbit serum of anti-rat kidney was initially prepared, and then injected into normal rats to induce the formation of masugi nephritis. In this model, KZ-36 was administrated (i.p.) at the dosage of 50 microg/kg/d for 2 weeks, while saline and hydrocortisone were respectively used as negative and positive controls. The pharmacodynamic parameters were collected.


RESULTS
After KZ-36 administration for one week, the protein output in 24 h urine remarkably decreased, and was 5.0 +/- 4.1 mg for two weeks, which was much less than 17.2 +/- 14.5 mg, a counterpart in saline control (P<0.01). KZ-36 could also reduce the serum level of creatinine and improve the renal pathological injury.


CONCLUSIONS
KZ-36 has obvious therapeutic effects on masugi nephritis in rats.
Zhang
Lei
L
Shenzhen Yitai Medicinal Research Company, Shenzhen 518029.
Chen
Xiaojuan
X
Jin
Aiqiong
A
D000419:Albuminuria / Q000652:urine; D000818:Animals; D002417:Cattle; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009393:Nephritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000737:chemistry*
D010455:Peptides; D003404:Creatinine