title: Thrombosis associated with L-asparaginase therapy and low fibrinogen levels in adult acute lymphoblastic leukemia.
abstract: L-asparaginase is a chemotherapeutic agent commonly used in the treatment of both adult and pediatric acute lymphoblastic leukemia (ALL). A major complication is thrombosis, resulting from reduced synthesis of proteins such as antithrombin III. Hypofibrinogenemia, also a side effect, may be a marker of thrombosis and decreased protein synthesis. A retrospective chart review of identically treated patients revealed 9 thrombotic events among 93 patients (10%), 6 (7%) occurring during treatment cycles including L-asparaginase. Twelve (13%) patients had fibrinogen levels <50 mg/dL. Of these, 3 (25%) suffered a thrombotic event. This results in a specificity of 90% and a relative risk of 10 (P = 0.014). Therefore, a fibrinogen <50 mg/dL may serve as a marker for a hypercoagulable state in ALL patients receiving L-asparaginase.
authors.affiliation: Department of Hematology/Oncology, University of California-San Francisco, San Francisco, California, USA. garthbeinart@msc.com
authors.forename: Garth
authors.initials: G
authors.lastname: Beinart
authors.forename: Lloyd
authors.initials: L
authors.lastname: Damon
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008499:Medical Records; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy*; D012189:Retrospective Studies; D013927:Thrombosis / Q000097:blood / Q000209:etiology*
chemical_list: D000970:Antineoplastic Agents; D005340:Fibrinogen; D001215:Asparaginase