title: Mammalian phylogenomics comes of age.
abstract: The relatively new field of phylogenomics is beginning to reveal the potential of genomic data for evolutionary studies. As the cost of whole genome sequencing falls, anticipation of complete genome sequences from divergent species, reflecting the major lineages of modern mammals, is no longer a distant dream. In this article, we describe how comparative genomic data from mammals is progressing to resolve long-standing phylogenetic controversies, to refine dogma on how chromosomes evolve and to guide annotation of human and other vertebrate genomes.
authors.affiliation: Basic Research Laboratory, SAIC-Frederick, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA. wmurphy@cvm.tamu.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Murphy
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Pevzner
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D016678:Genome; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D008322:Mammals / Q000235:genetics*; D008957:Models, Genetic; D010802:Phylogeny; D026801:Synteny