title: Facile preparation of an orthogonally protected, pH-sensitive, bioconjugate linker for therapeutic applications.
abstract: We describe the facile, three-step synthesis of an orthogonally protected, pH-sensitive linker (8), based on maleic acid, and report its application to the preparation of a pH-sensitive phospholipid (20) for potential use in drug and gene delivery. In addition, we highlight the benefits of our linker over the use of the commercially available cis-aconitic anhydride (4).
authors.affiliation: Department of Chemistry, Imperial College Genetic Therapies Centre, Imperial College London, Armstrong Road, London SW7 2AZ, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Fletcher
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jorgensen
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
mesh_terms: D006863:Hydrogen-Ion Concentration; D008298:Maleates / Q000737:chemistry*; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry
chemical_list: D008298:Maleates; D010743:Phospholipids; C030272:maleic acid