title: [Case report on intra-tumor injection therapy of dendritic cells in advanced gastric cancer].
abstract: Dendritic cells (DC) are powerful antigen-presenting cells, and have attracted attention in recent years from the viewpoint of DC vaccine therapy against cancer. However, the existence of an immunosuppressive state in cancer individuals leads to anergy and failure in cytotoxic T cell (CTL) induction and DC migration to the target organ. It has been reported that injected intra-tumor DCs are expected to work phagocytosis of the tumor as a localized effect. Consequently CTL induction in the tumor and the regional lymphnodes results in a systemic effect. In this study, intra-tumor DC injection therapy was performed by means of endoscopic ultrasonography (EUS) in 2 gastric cancer cases. As a result, tumor markers and ascites of one case were on the decrease. The results indicate this method can be useful in advanced cancer patients.
authors.affiliation: Dept of Surgery II, Fukushima Medical University.
authors.forename: Masashi
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoshihara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Abe
authors.forename: Manabu
authors.initials: M
authors.lastname: Iwadate
authors.forename: Kumiko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Endoh
authors.forename: Shinnji
authors.initials: S
authors.lastname: Ohki
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takita
authors.forename: Kouji
authors.initials: K
authors.lastname: Sekikawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takenoshita
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Takagi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohto
mesh_terms: D003713:Dendritic Cells / Q000637:transplantation*; D019160:Endosonography; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D015552:Injections, Intralesional; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000628:therapy*