Persistence of antibody response to pneumococcal capsular polysaccharides in vaccinated long term-care residents in Brazil.
To evaluate the immunogenicity of 23-valent pneumococcal polysaccharide vaccine in 52 nursing homes residents aged > or = 60 years, IgG antibodies to serotypes 1, 5, 6B, and 8 were measured by ELISA and compared before, and 1 and 12 months following vaccination. A significant immunological response for all serotypes was observed at 1 month after vaccination. The mean increase in antibody concentration was highly variable and ranged from 1.6 to 2.7. After 1 year, the mean concentrations remained significantly higher than prior to vaccination for serotypes 1, 6B, and 8, although there was a decrease in all mean IgG concentrations. Antibody levels were higher in men than in women, before and after immunisation. Post-vaccination values tended to be lower among subjects aged >75 years. Reduction in IgG concentrations by 33% 1 year after vaccination suggests that revaccination of institutionalised elderly people may be needed.
Brandão
Angela Pires
AP
Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21045-900, Brazil. abrandao@ial.sp.gov.br
de Oliveira
Tânia Cristina
TC
de Cunto Brandileone
Maria Cristina
MC
Gonçalves
Jorge Emílio
JE
Yara
Teresa Ikuko
TI
Simonsen
Vera
V
D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D014611:Vaccination
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial