title: Toxic acute hepatitis and hepatic fibrosis after consumption of chaparral tablets.
abstract: In this report we describe a young, previously healthy woman who developed severe acute hepatitis after consumption of chaparral tablets, a commonly used herbal product. In this case, the elimination-rechallenge event and the exclusion of other possible aetiologic factors strongly supported true causality between the herbal product and the liver damage. Primary liver biopsy showed severe toxic hepatitis consistent with previous reports of chaparral-induced liver damage. Later, 6 months after the liver function tests had normalized, permanent hepatic fibrosis could still be seen.
authors.affiliation: Department of Internal Medicine, Oulu University, FI-90220 Oulu, Finland. haikki.kauma@oulu.fi
authors.forename: H
authors.initials: H
authors.lastname: Kauma
authors.forename: R
authors.initials: R
authors.lastname: Koskela
authors.forename: H
authors.initials: H
authors.lastname: Mäkisalo
authors.forename: H
authors.initials: H
authors.lastname: Autio-Harmainen
authors.forename: J
authors.initials: J
authors.lastname: Lehtola
authors.forename: K
authors.initials: K
authors.lastname: Höckerstedt
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D032442:Larrea; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008517:Phytotherapy / Q000009:adverse effects*; D028321:Plant Preparations / Q000009:adverse effects*
chemical_list: D028321:Plant Preparations