title: Reduction of brain noise influence in evoked neuromagnetic source localization using noise spatial correlation.
abstract: In magnetoencephalographic measurements, magnetic fields caused by spontaneous brain activities not related to the neural activities under study are often referred to as brain noise. This is because the accuracy in neural source localization is considerably degraded by such spontaneous neuromagnetic fields. This paper reports the experimental results of applying the previously proposed noise covariance method to reducing the degradation caused by brain noise and to improving the accuracy in localizing auditory-evoked neural sources. Firstly we present the results of our experiments using measured brain noise and computer-generated signal fields. These results confirm that the covariance method can, in principle, improve the accuracy of evoked neural source localization. Next, the method was applied to source localization for actual neuromagnetic fields evoked by speech sounds. The results obtained strongly suggest that the method is effective in processing actual evoked neuromagnetic data.
authors.affiliation: Central Research Laboratory, Hitachi Ltd, PO Box 2, Kokubunji, Tokyo 185, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sekihara
authors.forename: F
authors.initials: F
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Kuriki
authors.forename: H
authors.initials: H
authors.lastname: Koizumi
mesh_terms: D000328:Adult; D000465:Algorithms; D016477:Artifacts; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D015233:Models, Statistical; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013269:Stochastic Processes