[The adrenocortical carcinoma, a tumour of wide clinical diversity].
Over the course of a few years, an obese 52-year-old woman with a 23-year history of hypertension developed a number of abdominal complaints including gall stones. Her blood pressure became increasingly difficult to control and she developed diabetes mellitus and suffered palpitations and headaches. It became noticeable that she had a moon face. Laboratory tests revealed hypercortisolism. CT-scan showed a large inhomogeneous mass of nine centimetres in her left adrenal gland, which was subsequently removed surgically. The histopathological diagnosis was consistent with an adenoma. After a number of months the patient developed bone and liver metastases and the diagnosis was amended to carcinoma of the adrenal cortex. She then underwent radiotherapy and chemotherapy treatment. One year after surgery she developed a pancytopenia and died. Adrenocortical carcinomas are rare tumours with an incidence of about 1-2 cases per million of the population. Symptoms are heterogeneous since both functional (hormonal overproduction) and non-functional (mass effect) tumours exist. Surgical resection is the only curative therapy. It may be difficult to distinguish between benign and malignant cortical tumours.
Schreinemakers
J M J
JM
Universitair Medisch Centrum Utrecht, Heidelberglaan 100, 3584 CX Utrecht.
van Dam
P S
PS
Seldenrijk
C A
CA
Biesma
D H
DH
Borel Rinkes
I H M
IH
D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018268:Adrenocortical Carcinoma / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D001859:Bone Neoplasms / Q000556:secondary; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008875:Middle Aged