title: The role of cystic fibrosis gene mutations in determining susceptibility to chronic pancreatitis.
abstract: This article reviews current concepts regarding the pathobiology of cystic fibrosis pancreatic disease. It summarizes recent studies on the relationship between CFTR mutations and pancreatitis, and it reviews several unresolved issues in the field.
authors.affiliation: Veterans Administration Medical Center, 508 Fulton Street, Durham, NC 27705, USA. cohn0001@mc.duke.edu
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Cohn
authors.forename: R Michael
authors.initials: RM
authors.lastname: Mitchell
authors.forename: Paul S
authors.initials: PS
authors.lastname: Jowell
mesh_terms: D015209:Cholangitis, Sclerosing / Q000235:genetics; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000235:genetics / Q000503:physiopathology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D009154:Mutation; D010195:Pancreatitis / Q000235:genetics* / Q000503:physiopathology; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000235:genetics
chemical_list: C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D014359:Trypsin Inhibitor, Kazal Pancreatic