Single-layer small intestinal submucosa or tunica vaginalis flap for correcting penile chordee.
OBJECTIVE
To evaluate the use of single-layer small intestinal submucosa (SIS) and tunica vaginalis flap (TVF) for covering defects in the ventral surface of the tunica albuginea to correct severe penile chordee.


METHODS
In all, 24 New Zealand white rabbits had a rectangular area excised from the ventral surface of tunica albuginea. In 12 rabbits TVF was used to cover the defect and in the remaining animals single-layer SIS was used. Animals were killed in groups of four at 2-, 6- and 12-week intervals after surgery. Before death in the 12-week group, an artificial erection was induced and cavernosography performed. Transverse sections of the penis at the graft site were stained with haematoxylin and eosin and Masson's trichrome, and examined microscopically.


RESULTS
None of the animals developed haematoma or bleeding. The mean operative duration for TVF and SIS grafts were 56 and 29 min, respectively (P < 0.001). At the time of autopsy, there was no contracture in any of the rabbits. Of the 8 rabbits assessed, all had a straight rigid erection and cavernosography showed evidence of an intact corporal veno-occlusive mechanism. Histologically at 6 and 12 weeks, the mesothelial layers of the TVF and the SIS graft were completely replaced by well-collagenized tissue similar to that of normal tunica albuginea, with no inflammatory infiltrate.


CONCLUSIONS
Both the TVF and single-layer SIS graft are viable comparable options for corporal body grafting. The 'off-the-shelf' availability, significantly quicker operation and absence of donor site morbidity make single-layer SIS better than TVF for correcting chordee.
El-Assmy
Ahmed
A
Urology & Nephrology Center, Mansoura University, Mansoura, Egypt.
El-Hamid
Mohamed Abd
MA
Abo-Elghar
Mohamed E
ME
Hafez
Ashraf T
AT
D000818:Animals; D007413:Intestinal Mucosa / Q000637:transplantation*; D008297:Male; D010409:Penile Diseases / Q000473:pathology / Q000601:surgery*; D010413:Penis / Q000601:surgery*; D011817:Rabbits; D013524:Surgical Flaps / Q000473:pathology