Depletion rate of doramectin from blood serum of penned female white-tailed deer (Artiodactyla: Cervidae).
Female white-tailed deer, Odocoileus virginianus (Zimmerman), were held in small pens and administered doramectin by free choice of doramectin-coated whole kernel corn, Zea mays L., fed ad libitum with 19% protein deer pellets also being fed ad libitum in a separate container. The mean concentration of doramectin in the serum during treatment was 72.8 ppb. The mean doramectin concentration in the serum decreased to <2 ppb, the lower limit of detection by high-pressure liquid chromatography, by day 14 after termination of treatment after withdrawal of doramectin-treated corn from the diet.
Pound
J Mathews
JM
USDA-ARS-Knipling-Bushland U.S. Livestock Insects Research Laboratory, 2700 Fredericksburg Road, Kerrville, TX 78028-9184, USA.
Miller
J Allen
JA
Oehler
Delbert D
DD
D000821:Animal Feed; D000818:Animals; D003670:Deer / Q000097:blood*; D005260:Female; D007306:Insecticides / Q000097:blood*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000097:blood* / Q000493:pharmacokinetics; D008657:Metabolic Clearance Rate; D013781:Texas; D003313:Zea mays
D007306:Insecticides; D007559:Ivermectin; C084101:doramectin