Two cases of fatal shock after transfusion of platelets contaminated by Staphylococcus aureus: role of superantigenic toxins.
We detected Staphylococcus aureus superantigenic toxins in the platelet infusion bags that had been used for 2 patients who subsequently developed transfusion-associated Staphylococcus aureus infection. Both patients, who were immunodeficient, developed manifestations of toxic shock syndrome and septic shock, and they died soon after the onset of infection.
Perpoint
Thomas
T
Centre National de Référence des Staphylocoques, INSERM E0230, Institute Fédératif de Recherche 62, Lyon, France.
Lina
Gerard
G
Poyart
Claire
C
de Barbeyrac
Bertille
B
Traineau
Richard
R
Jeanne
Michel
M
Vandenesch
François
F
Etienne
Jerome
J
D000368:Aged; D000942:Antigens, Bacterial / Q000502:physiology; D004768:Enterotoxins / Q000502:physiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000009:adverse effects*; D012772:Shock, Septic / Q000209:etiology*; D013211:Staphylococcus aureus
D000942:Antigens, Bacterial; D004768:Enterotoxins; C031818:enterotoxin B, staphylococcal