title: Massive congenital intracranial teratoma: perioperative coagulation impairment.
abstract: Massive congenital intracranial teratoma is a rare neoplasm with a poor prognosis. Surgery may be curative only if complete resection can ben obtained. Several single case reports have been published in the pediatric literature, mostly focusing on prenatal diagnosis. The authors describe six patients with congenital intracranial teratoma treated at their institution in the past decade. Perioperatively, a marked hemostatic derangement was observed in three of them undergoing surgery: the pathophysiology of this complication is discussed. The surgical indication itself represents an ethical dilemma when treating a large intracranial tumor with partial destruction and replacement of brain structures.
authors.affiliation: Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy. xoct01@yahoo.it
authors.forename: Marco
authors.initials: M
authors.lastname: Piastra
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Decarolis
authors.forename: Alessia
authors.initials: A
authors.lastname: Tempera
authors.forename: Elena
authors.initials: E
authors.lastname: Caresta
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Polidori
authors.forename: Antonio
authors.initials: A
authors.lastname: Chiaretti
authors.forename: Domenico
authors.initials: D
authors.lastname: Pietrini
authors.forename: Antonio
authors.initials: A
authors.lastname: Ruggiero
authors.forename: Massimo
authors.initials: M
authors.lastname: Caldarelli
authors.forename: Concezio
authors.initials: C
authors.lastname: Di Rocco
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D001932:Brain Neoplasms / Q000151:congenital* / Q000175:diagnosis / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013724:Teratoma / Q000151:congenital* / Q000175:diagnosis / Q000601:surgery