The role of thrombospondin-1 in human disease.
Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein secreted by many cell types. It is a component of the extracellular matrix during active and subacute processes. Due to TSP-1's ability to interact with a variety of matrix proteins and cell-surface receptors, controversy exists about its conflicting functions. In this review, we will discuss the role of TSP-1 in human disease.
Esemuede
Nowokere
N
Yale University School of Medicine, New Haven, Connecticut, USA.
Lee
Taeseung
T
Pierre-Paul
Daphne
D
Sumpio
Bauer E
BE
Gahtan
Vivian
V
D004194:Disease; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000378:metabolism; D018919:Neovascularization, Physiologic; D010974:Platelet Aggregation; D019700:Thrombospondin 1 / Q000378:metabolism*; D014652:Vascular Diseases / Q000503:physiopathology; D014945:Wound Healing
D019700:Thrombospondin 1