title: Telomeres thrown for a loop.
abstract: A remarkable paper from the de Lange lab (Wang et al., 2004) in a recent issue of Cell reveals that homologous recombination can result in the abrupt shortening of telomeres in a process that appears to involve reciprocal crossing over within the t-loop structure that protects chromosome ends.
authors.affiliation: Brandeis University, Waltham, Massachusetts 02454, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Haber
mesh_terms: D002461:Cell Line, Transformed; D002842:Chromatids / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism; D003434:Crossing Over, Genetic; D045566:DNA, Cruciform / Q000378:metabolism; D017404:In Situ Hybridization, Fluorescence; D008954:Models, Biological; D045522:Recombinases / Q000378:metabolism; D011995:Recombination, Genetic; D017384:Sequence Deletion; D016615:Telomere / Q000737:chemistry*; D035341:Telomeric Repeat Binding Protein 2 / Q000378:metabolism
chemical_list: D045566:DNA, Cruciform; D045522:Recombinases; D035341:Telomeric Repeat Binding Protein 2