Donor-recipient gender mismatch in lung transplantation: impact on obliterative bronchiolitis and survival.
BACKGROUND
Because of the shortage of donor lungs, liberalization of donor selection criteria in terms of age, gas exchange, and smoking history has been proposed.


METHODS
We evaluated a single-institution population of lung transplant recipients (n = 98) for donor-recipient gender matching. We measured overall survival, time to acute allograft rejection, and time to development of obliterative bronchiolitis (OB).


RESULTS
We found significant improvement in overall survival for gender-mismatched donor and recipient pairs (p = 0.078) and a significantly shorter OB-free period for male donor and female recipient pairs (p = 0.017).


CONCLUSIONS
These findings suggest that donor organ allocation based on gender may affect long-term survival and other outcomes after lung transplantation.
Roberts
David H
DH
Pulmonary and Critical Care Unit, General Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Wain
John C
JC
Chang
Yuchiao
Y
Ginns
Leo C
LC
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001989:Bronchiolitis Obliterans / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D014019:Tissue Donors