Polymer-supported Mukaiyama reagent: a useful coupling reagent for the synthesis of esters and amides.
Polymer-supported N-alkyl-2-chloro pyridinium triflate was synthesized in one step from Wang resin. This reagent proved to be a very effective coupling reagent for the synthesis of esters or amides from carboxylic acids and alcohols or amines (primary and secondary). [reaction: see text]
Crosignani
Stefano
S
Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
Gonzalez
Jerome
J
Swinnen
Dominique
D