title: Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y.
abstract: We report a genome-wide search of Y-linked genes in Drosophila pseudoobscura. All six identifiable orthologs of the D. melanogaster Y-linked genes have autosomal inheritance in D. pseudoobscura. Four orthologs were investigated in detail and proved to be Y-linked in D. guanche and D. bifasciata, which shows that less than 18 million years ago the ancestral Drosophila Y chromosome was translocated to an autosome in the D. pseudoobscura lineage. We found 15 genes and pseudogenes in the current Y of D. pseudoobscura, and none are shared with the D. melanogaster Y. Hence, the Y chromosome in the D. pseudoobscura lineage appears to have arisen de novo and is not homologous to the D. melanogaster Y.
authors.affiliation: Departamento de Genética, Universidade Federal do Rio de Janeiro, Caixa Postal 68011, CEP 21944-970, Rio de Janeiro, Brazil. bernardo@biologia.ufrj.br
authors.forename: Antonio Bernardo
authors.initials: AB
authors.lastname: Carvalho
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Clark
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002875:Chromosomes / Q000235:genetics / Q000502:physiology; D021901:DNA, Intergenic; D004330:Drosophila / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D017344:Genes, Insect; D008040:Genetic Linkage; D016678:Genome; D007438:Introns; D008297:Male; D008957:Models, Genetic; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011544:Pseudogenes; D014178:Translocation, Genetic; D014960:X Chromosome / Q000235:genetics / Q000502:physiology; D014998:Y Chromosome / Q000235:genetics* / Q000502:physiology*
chemical_list: D021901:DNA, Intergenic