title: Multiple granulomatous inflammation in the minor salivary glands: a proposed new entity, allergic granulomatous sialadenitis.
abstract: We report a patient who presented with multiple small submucosal nodules with granulomatous inflammation in the minor salivary glands of the oral cavity. A 43-year-old woman presented with a 1-week history of multiple small submucosal nodules in her oral cavity after having taken medicine for abdominal pain. The patient did not have a history of fever, rectal bleeding, skin lesions or arthritis, but did have a history of drug allergy and bronchial asthma. Histopathological examination of the submucosal nodules showed sialadenitis with marked infiltration of lymphocytes, eosinophilic cells, macrophages and Langhans-type or foreign-body-type multinucleate giant cells. The macrophages tended to be aggregated and appeared to have caused immature granuloma formation without caseous necrosis. Degranulated eosinophilic cells were numerous. Sarcoidosis, Crohn's disease, tuberculosis and atypical mycobacterial infection were not identified by medical examination. Three weeks after discontinuing the medication the patient was seen again at a follow-up visit. Multiple submucosal small nodules and other symptoms were not evident at that time. This case report may represent a new entity of salivary gland disease that we tentatively refer to as 'allergic granulomatous sialadenitis'.
authors.affiliation: Department of Oral Pathology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan. tarou@dent.showa-u.ac.jp
authors.forename: Tarou
authors.initials: T
authors.lastname: Irié
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Maeda
authors.forename: Tadateru
authors.initials: T
authors.lastname: Aida
authors.forename: Kaname
authors.initials: K
authors.lastname: Sumitani
authors.forename: Masao
authors.initials: M
authors.lastname: Nagumo
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Tachikawa
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy; D000328:Adult; D000897:Anti-Ulcer Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D004798:Enzymes / Q000009:adverse effects; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007249:Inflammation / Q000209:etiology* / Q000276:immunology / Q000473:pathology*; D008107:Liver Diseases / Q000209:etiology; D010880:Piperidines / Q000009:adverse effects; D011899:Ranitidine / Q000009:adverse effects; D012470:Salivary Glands, Minor / Q000276:immunology / Q000473:pathology*; D012793:Sialadenitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology
chemical_list: D000897:Anti-Ulcer Agents; D004798:Enzymes; D010880:Piperidines; D011899:Ranitidine; C001739:timepidium bromide; C028936:troxipide