Membrane bound members of the M1 family: more than aminopeptidases.
In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad range of peptides down to only to a single peptide. This ability to either generate or degrade active peptide hormones is the focus of this review. In addition to their capacity to degrade a range of peptides a number of these aminopeptidases have novel functions that impact on cell signalling and will be discussed.
Albiston
Anthony L
AL
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3010 Australia. albist@hfi.unimelb.edu.au
Ye
Siying
S
Chai
Siew Yeen
SY
D000626:Aminopeptidases / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D018826:CD13 Antigens / Q000737:chemistry / Q000378:metabolism; D010122:Cystinyl Aminopeptidase; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D015778:Minor Histocompatibility Antigens; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
D008565:Membrane Proteins; D015778:Minor Histocompatibility Antigens; D000626:Aminopeptidases; C464841:ERAP1 protein, human; D018826:CD13 Antigens; D010122:Cystinyl Aminopeptidase; C105964:leucyl-cystinyl aminopeptidase; C023166:pyroglutamyl-peptidase II; D011761:Pyrrolidonecarboxylic Acid