The genetic basis for the commitment to chronic versus acute infection in Pseudomonas aeruginosa.
The opportunistic pathogen Pseudomonas aeruginosa causes both acute and chronic airway infections. In a recent issue of Developmental Cell, Goodman et al. (2004) show that the RetS two-component gene regulatory module inversely controls expression of genes associated with acute and chronic infection.
Yahr
Timothy L
TL
Department of Microbiology, The W.M. Keck Microbial Communities and Cell Signaling Program, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.
Greenberg
E Peter
EP
D000208:Acute Disease; D002908:Chronic Disease; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005809:Genes, Regulator; D009154:Mutation; D011552:Pseudomonas Infections / Q000235:genetics* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000472:pathogenicity*; D015398:Signal Transduction