Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age.
Case-control study designed to determine the effectiveness of an MF59-adjuvanted influenza vaccine in the population aged 65 years and older living in the community. Detailed health histories were obtained on both cases and controls that included a functional measure of co-morbidity (Barthel Index). Subjects were all eligible persons admitted to various hospitals with a diagnosis of pneumonia during the winter months and were matched by sex, hospital and admission week to controls admitted for non-medical reasons. The influenza vaccination programme using the MF59-adjuvanted influenza vaccine significantly reduced the probability of being hospitalised for pneumonia in the elderly over 64 years of age, even in a season with a low influenza activity, during which the predominant circulating strains were types B and A (H1N1).
Puig-Barberà
Joan
J
Grupo de Trabajo Vacunas (CAVA) de la Sociedad Valenciana de Medicina Familiar y Comunitaria, Valencia, Spain. jpuigb@terra.es
Diez-Domingo
Javier
J
Pérez Hoyos
Santiago
S
Belenguer Varea
Angel
A
González Vidal
David
D
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D022242:Pneumococcal Vaccines; D011018:Pneumonia, Pneumococcal / Q000276:immunology / Q000517:prevention & control*; D011136:Polysorbates / Q000008:administration & dosage*; D012307:Risk Factors; D013185:Squalene / Q000008:administration & dosage*
D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines; C089950:MF59 oil emulsion; D022242:Pneumococcal Vaccines; D011136:Polysorbates; D013185:Squalene