Effect of trospium chloride on somnolence and sleepiness in patients with overactive bladder.
An objective of a large US phase-3 study was to determine the effects of trospium chloride 20-mg tablets versus placebo, administered twice daily, on central nervous system (CNS) adverse events (eg, somnolence) and on daytime sleepiness using the validated Stanford Sleepiness Scale. The impact of age groups also was assessed. Trospium chloride did not increase daytime sleepiness or appear to produce CNS adverse effects, as measured by the Stanford Sleepiness Scale and the incidence of CNS adverse events. Furthermore, there was no difference in these findings across age groups.
Staskin
David R
DR
Department of Urology, Weil-Cornell Medical College, New York, NY 10021, USA. das2021@med.cornell.edu
Harnett
Mark D
MD
D001561:Benzilates; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D009662:Nortropanes / Q000009:adverse effects* / Q000627:therapeutic use; D010276:Parasympatholytics / Q000009:adverse effects* / Q000627:therapeutic use; D012894:Sleep Stages / Q000187:drug effects; D014549:Urinary Incontinence / Q000188:drug therapy*
D001561:Benzilates; D018727:Muscarinic Antagonists; D009662:Nortropanes; D010276:Parasympatholytics; C003330:trospium chloride