Medical therapy for ulcerative colitis: the state of the art and beyond.
Ulcerative colitis (UC) is an idiopathic inflammatory condition of the large intestine. Recent advances in our understanding of the pathogenesis of UC have led to the development of novel treatments for this often debilitating condition. Aside from aminosalicylates and corticosteroids, drugs that have been used for decades in the treatment of UC, biologic agents, in addition to medications targeting specific effector mechanisms involved in the inflammatory cascade, have been used in patients with UC with varying degrees of success. Clinicians have never had as many therapeutic options for UC as they do today. Herein we review the variety of treatment options, both standard and investigational, that are available for patients with UC.
Ross
Andrew S
AS
Department of Medicine, Section of Gastroenterology, The University of Chicago Hospitals, 5841 S. Maryland Avenue, MC 4076, Chicago, IL 60637, USA.
Cohen
Russell D
RD
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002087:Butyrates / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use; D004815:Epidermal Growth Factor / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000069285:Infliximab; D007372:Interferons / Q000627:therapeutic use; D015122:Mercaptopurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010956:Plasmapheresis; D019936:Probiotics / Q000627:therapeutic use; D012074:Remission Induction; D013844:Thiazoles / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000964:Antimetabolites, Antineoplastic; D002087:Butyrates; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D013844:Thiazoles; C488629:azathiopurine; D004815:Epidermal Growth Factor; D016572:Cyclosporine; D007372:Interferons; D000069285:Infliximab; D015122:Mercaptopurine; C456519:visilizumab; C108965:tetomilast