Neprilysin 2: a novel messenger peptide-inactivating metalloprotease.
Neprilysin 2 is a recently identified glycoprotein displaying the highest degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 family of zinc-dependent metalloproteases. Whereas neprilysin has been shown to be involved in the inactivation of endogenous messenger peptides, like enkephalins and tachykinins, the true physiological functions of neprilysin 2 remain unknown.
Ouimet
Tanja
T
Unité de Neurobiologie et Pharmacologie Moléculaire (U573) de l'INSERM. Centre Paul Broca, 2ter rue d'Alésia, 75014 Paris, France. Ouimet@broca.inserm.fr.
D000818:Animals; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015260:Neprilysin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D036341:Intercellular Signaling Peptides and Proteins; D007527:Isoenzymes; D015260:Neprilysin