title: Electromechanical coupling, uncoupling, and ventricular function in patients with bundle branch block: a tissue-Doppler echocardiographic study.
abstract: BACKGROUND
  Left bundle branch block (LBBB) is associated with impaired left ventricular (LV) function and increased morbidity and mortality, especially in patients with structural heart diseases. The mechanisms are poorly understood.
  
  
  METHODS
  Subjects with isolated LBBB (n=20), right bundle branch block (RBBB, n=20), and controls (C, n=20) were studied with standard two-dimensional (2D), and color-encoded tissue-Doppler echocardiography (TDE). Inter- and intraventricular systolic and diastolic coordination were assessed from the TDE velocity profiles. LV function was assessed by 2D echocardiography, by TDE-derived peak systolic velocities, and the atrioventricular (AV) plane displacement.
  
  
  RESULTS
  Subjects with LBBB had longer electromechanical delays and longer isovolumic relaxation times than did the C and RBBB groups (P <0.001). For the LBBB subjects compared with the RBBB and C groups, ejection times were shorter, peak systolic velocities and AV plane displacements were lower, they had larger LV end-systolic volumes and lower LV ejection fraction (all P <0.001), and the atrial contribution to A-V plane displacement was higher (P <0.01). There were no differences in diastolic or filling times among the groups.
  
  
  CONCLUSIONS
  In patients with LBBB, delayed regional electromechanical coupling and uncoupling leads to generalized intra- and interventricular asynchrony, thereby explaining the depressed regional and global LV functions. Assessment of the electromechanical coupling and uncoupling processes and their consequences on cardiac function in patients with BBB and structural heart diseases may be possible using TDE.
authors.affiliation: Department of Clinical Physiology and Cardiology, Huddinge University Hospital, Sweden. miguel.quintana@labmed.ki.se
authors.forename: Miguel
authors.initials: M
authors.lastname: Quintana
authors.forename: Samir
authors.initials: S
authors.lastname: Saha
authors.forename: Morteza
authors.initials: M
authors.lastname: Rohani
authors.forename: Francesca
authors.initials: F
authors.lastname: del Furia
authors.forename: Simin
authors.initials: S
authors.lastname: Roumina M
authors.forename: Britta
authors.initials: B
authors.lastname: Lind
authors.forename: Shirley
authors.initials: S
authors.lastname: Hayashi
authors.forename: Lars-Ake
authors.initials: LA
authors.lastname: Brodin
mesh_terms: D000704:Analysis of Variance; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*