title: Decreased levofloxacin susceptibility in Haemophilus influenzae in children, Hong Kong.
abstract: Among 563 strains of Haemophilus influenzae from young children in Hong Kong, 5 (0.9%) had decreased susceptibility to quinolones. The five strains had a Ser-84-Lys or Asp-88-Asn substitution in GyrA. Pulsed-field gel electrophoresis showed that the isolates are genetically diverse.
authors.affiliation: Division of Infectious Diseases, Department of Microbiology and Centre of Infection, University of Hong Kong, Hong Kong Special Administrative Region, China. plho@hkucc.hku.hk
authors.forename: Pak-Leung
authors.initials: PL
authors.lastname: Ho
authors.forename: Kin Hung
authors.initials: KH
authors.lastname: Chow
authors.forename: Gannon C
authors.initials: GC
authors.lastname: Mak
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Tsang
authors.forename: Yu Lung
authors.initials: YL
authors.lastname: Lau
authors.forename: Alex Y
authors.initials: AY
authors.lastname: Ho
authors.forename: Eileen L
authors.initials: EL
authors.lastname: Lai
authors.forename: Susan S
authors.initials: SS
authors.lastname: Chiu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006193:Haemophilus influenzae / Q000187:drug effects*; D006723:Hong Kong; D006801:Humans; D007223:Infant; D064704:Levofloxacin; D009268:Nalidixic Acid / Q000494:pharmacology; D009305:Nasopharynx / Q000382:microbiology; D015242:Ofloxacin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009268:Nalidixic Acid; D064704:Levofloxacin; D015242:Ofloxacin