title: Thyroid metastasis from renal cell carcinoma eight years after radical nephrectomy: a case report.
abstract: A forty-five-year-old female patient presented with thyroid nodules eight years after radical nephrectomy for renal cell carcinoma (T2N0M0, grade 2, clear cell subtype) in the right kidney. Ultrasonography of the neck showed multiple hypoechoic macronodules. There was no lymphadenomegaly. During total thyroidectomy following an initial diagnosis of multinodular goiter, frozen section analysis was made, which showed metastasis from renal cell carcinoma. Immunohistochemical studies demonstrated that the tumor cells were negative for thyroglobulin staining. No recurrences or other metastatic disease were seen during a follow-up period of 12 months. Although clinically the thyroid gland is a rare site for tumor metastasis, this possibility should be kept in mind in patients with a previous history of renal cell carcinoma.
authors.affiliation: Department of General Surgery, VKV American Hospital, Istanbul, Turkey. cananuzel@hotmail.com
authors.forename: Canan
authors.initials: C
authors.lastname: Uzel
authors.forename: Halil
authors.initials: H
authors.lastname: Coşkun
authors.forename: Tarik
authors.initials: T
authors.lastname: Terzioğlu
authors.forename: Necdet
authors.initials: N
authors.lastname: Aras
mesh_terms: D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D013965:Thyroidectomy