Xenograft transplantation.
Interest in xenotransplantation has increased because conventional organ transplantation has been limited by a shortage of human organs. Although xenotransplantation could alleviate the existing and anticipated need for tissues and organs, the application is hindered by various biologic obstacles. This article reviews the basis for the demand for xenotransplantation, the obstacles to clinical application, and potential approaches to overcoming those obstacles.
Khalpey
Zain
Z
Transplantation Biology, Mayo Clinic, Rochester, MN 55905, USA.
Koch
Cody A
CA
Platt
Jeffrey L
JL
D000758:Anesthesia; D000818:Animals; D005544:Forecasting; D006085:Graft Survival; D006801:Humans; D014183:Transplantation, Heterologous / Q000276:immunology / Q000639:trends