CD8 memory T cells: cross-reactivity and heterologous immunity.
Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.
Selin
Liisa K
LK
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Liisa.Selin@umassmed.edu
Cornberg
Markus
M
Brehm
Michael A
MA
Kim
Sung-Kwon
SK
Calcagno
Claudia
C
Ghersi
Dario
D
Puzone
Roberto
R
Celada
Franco
F
Welsh
Raymond M
RM
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003429:Cross Reactions; D007116:Immunization, Passive; D007156:Immunologic Memory; D007519:Isoantigens / Q000378:metabolism; D008432:Mathematical Computing; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology
D007519:Isoantigens