title: Synthetic studies on the taxane skeleton: construction of eight-membered carbocyclic rings by the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction.
abstract: Construction of eight-membered carbocyclic rings via the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction has been studied. This protocol proved its potency through the formation of the eight-membered ring possessing a quaternary carbon on its ring in high yield, affording promise of a new access to the eight-membered ring of Taxol. [reaction: see text]
authors.affiliation: Department of Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan.
authors.forename: Hatsuo
authors.initials: H
authors.lastname: Kawada
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Iwamoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Utsugi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyano
authors.forename: Masahisa
authors.initials: M
authors.lastname: Nakada