Inhibitory adaptors in lymphocytes.
The negative regulation of lymphocyte activation and function is mediated by inhibition of signaling through antigen-receptor, co-stimulation receptor or cytokine receptor. The suppression of downstream signaling through antigen-receptor is mediated by negative regulators including adaptors and effectors such as phosphatases. "Inhibitory adaptors" exhibit their inhibitory function directly or indirectly by the localization to the vicinity of the antigen-receptor on the membrane. The strategy of inhibition by inhibitory adaptors includes the recruitment of inhibitory effector molecules, sequestration of positive regulators, internalization/degradation of receptor complexes, and the blockade of the dynamic movement of positive regulators.
Yamasaki
Sho
S
Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. sho@rcai.riken.jp
Saito
Takashi
T
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing