title: Associations in the course of personality disorders and Axis I disorders over time.
abstract: In this study, the authors examined time-varying associations between schizotypal (STPD), borderline (BPD), avoidant (AVPD), or obsessive-compulsive (OCPD) personality disorders and co-occurring Axis I disorders in 544 adult participants from the Collaborative Longitudinal Personality Disorders Study. The authors tested predictions of specific longitudinal associations derived from a model of crosscutting psychobiological dimensions (L. J. Siever & K. L. Davis, 1991) with participants with the relevant Axis I disorders. The authors assessed participants at baseline and at 6-, 12-, and 24-month follow-up evaluations. BPD showed significant longitudinal associations with major depressive disorder and posttraumatic stress disorder. AVPD was significantly associated with anxiety disorders (specifically social phobia and obsessive-compulsive disorder). Two of the four personality disorders under examination (STPD and OCPD) showed little or no association with Axis I disorders.
authors.affiliation: Department of Psychiatry and Human Behavior, Brown University Medical School, Duncan Building, 700 Butler Drive, Providence, RI 20906, USA. M_Shea@Brown.edu
authors.forename: M Tracie
authors.initials: MT
authors.lastname: Shea
authors.forename: Robert L
authors.initials: RL
authors.lastname: Stout
authors.forename: Shirley
authors.initials: S
authors.lastname: Yen
authors.forename: Maria E
authors.initials: ME
authors.lastname: Pagano
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Skodol
authors.forename: Leslie C
authors.initials: LC
authors.lastname: Morey
authors.forename: John G
authors.initials: JG
authors.lastname: Gunderson
authors.forename: Thomas H
authors.initials: TH
authors.lastname: McGlashan
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Grilo
authors.forename: Charles A
authors.initials: CA
authors.lastname: Sanislow
authors.forename: Donna S
authors.initials: DS
authors.lastname: Bender
authors.forename: Mary C
authors.initials: MC
authors.lastname: Zanarini
mesh_terms: D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology*; D010554:Personality Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012074:Remission Induction; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology*; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000453:epidemiology*