Etiology of azoospermia in 100 consecutive nonvasectomized men.
History was taken systematically for 100 azoospermic, nonvasectomized men referred consecutively to a Danish fertility clinic. The men were examined by ultrasound, and their blood samples were analyzed for karyotype, Y microdeletions, and cystic fibrosis transmembrane conductance regulator gene mutations. In 29% of patients, the condition could be explained by genetic abnormalities; in 22%, by diseases or external influence; and in 27%, by former cryptorchidism. The azoospermic condition remained unexplained in only 22%.
Fedder
Jens
J
The Fertility Clinic, Braedstrup Hospital, Braedstrup, Denmark. jfe@bs.vejleamt.dk
Crüger
Dorthe
D
Oestergaard
Birthe
B
Petersen
Gert Bruun
GB
D003456:Cryptorchidism / Q000150:complications; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D009845:Oligospermia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D014463:Ultrasonography; D014649:Vas Deferens / Q000002:abnormalities
C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator