Morphologic changes in neo-intimal proliferation in an experimental aneurysm after coil embolization: effect of factor XIII administration.
We investigated histological changes in aneurysmal orifices after embolization with Guglielmi detachable coils (GDCs) and determined the effects of the wound-healing factor, factor XIII, on promoting intimal proliferation by scanning electron microscopy (SEM). GDC embolization was performed in an experimental model of aneurysm in swine. In the control group (17 aneurysms), the aneurysms were resected immediately after surgery, at 1 and 3 weeks after the procedure. In the factor XIII-administered group (13 aneurysms), the swine received factor XIII postoperatively, and the aneurysms were excised at 1 and 3 weeks. The endothelial cell proliferation changes in the aneurysm orifices in both groups were evaluated by SEM. The histological changes at the orifices began immediately after the procedure, and endothelialization was observed at 1 week. One week after the procedure, the rate of endothelial cell proliferation was significantly higher in the factor XIII group (P<0.05). But no difference was observed at 3 weeks, when endothelialization of the orifices was essentially completed. The process of intimal proliferation after coil embolization was similar to the wound-healing process after vascular intimal injury. Administration of the wound-healing factor, factor XIII, would contribute rapid intimal proliferation and may be effective to facilitate complete obliteration of aneurysms after coil embolization.
Hino
Ken
K
Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan. khino68@hotmail.com
Konishi
Yoshifumi
Y
Shimada
Atsushi
A
Kurita
Hiroki
H
Sato
Eishi
E
Hara
Mitsuhiro
M
Shiokawa
Yoshiaki
Y
Saito
Isamu
I
D000818:Animals; D017536:Carotid Artery, Common / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic; D042783:Endothelial Cells / Q000187:drug effects; D005176:Factor XIII / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D002532:Intracranial Aneurysm / Q000473:pathology* / Q000628:therapy*; D013552:Swine; D013997:Time Factors; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D014945:Wound Healing / Q000187:drug effects
D005176:Factor XIII