title: The influence of orchiopexy on serum inhibin B level: relationship with histology.
abstract: OBJECTIVE
  Since inhibin B is the endocrine marker of spermatogenesis, basal inhibin B levels may reflect germ cell status in children. The aims of this study were to determine the changes in endocrine parameters after orchiopexy in patients with cryptorchidism and to compare these findings with testicular biopsy parameters.
  
  
  METHODS
  A total of 27 boys with undescended testis were included in this study. Inguinal orchiopexy was performed in all patients and 15 underwent testicular biopsy at orchiopexy. Spermatogonia per tubular transverse section and fertility index values were determined. Before and 6 months after orchiopexy serum basal inhibin B and other serum hormone levels were measured in all patients.
  
  
  RESULTS
  Mean serum basal inhibin B levels significantly increased 6 months after successful orchiopexy (p = 0.001). However, inhibin B level did not increase in patients who had a low testicular biopsy score. Other reproductive hormone levels did not change after orchiopexy.
  
  
  CONCLUSIONS
  Basal inhibin B level could be used as a followup parameter after orchiopexy. If basal inhibin B level does not increase in the postoperative period, the amount of germ cells in the testis may be too low or the orchiopexy might not have been implemented appropriately.
authors.affiliation: Department of Urology, Gülhane Military Medical Academy, School of Medicine, Ankara, Turkey.
authors.forename: H Cem
authors.initials: HC
authors.lastname: Irkilata
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yildirim
authors.forename: Onder
authors.initials: O
authors.lastname: Onguru
authors.forename: Emin
authors.initials: E
authors.lastname: Aydur
authors.forename: Ugur
authors.initials: U
authors.lastname: Musabak
authors.forename: Murat
authors.initials: M
authors.lastname: Dayanc
mesh_terms: D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000097:blood* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007265:Inhibins / Q000097:blood*; D008297:Male; D013521:Urologic Surgical Procedures, Male
chemical_list: C422364:inhibin B; D007265:Inhibins