title: Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection.
abstract: Mice were infected with lymphocytic choriomeningitis virus (LCMV) to determine if changes in CD1d expression occurred during an acute virus infection. It is interesting that a decrease in CD1d expression on splenic dendritic cells (DC) and macrophages (MPhi) was observed for at least 3 months post-LCMV infection, and vaccinia virus and vesicular stomatitis virus induced similar changes in CD1d upon infection with those viruses. The reduction of CD1d cell-surface expression on DC and MPhi was independent of interferon-gamma and interleukin-12 expression but partially recovered in transporter associated with antigen processing-1-deficient mice, suggesting that CD8+ T cells may play a role. Thus, one consequence of the induction of a cellular immune response is a change in CD1d expression, which may constitute a key element in regulating antiviral immunity.
authors.affiliation: Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, and The Walther Cancer Institute, Indianapolis, IN 46202-5181, USA.
authors.forename: Yinling
authors.initials: Y
authors.lastname: Lin
authors.forename: Tonya J
authors.initials: TJ
authors.lastname: Roberts
authors.forename: Philip M
authors.initials: PM
authors.lastname: Spence
authors.forename: Randy R
authors.initials: RR
authors.lastname: Brutkiewicz
mesh_terms: D000208:Acute Disease; D000818:Animals; D018949:Antigens, CD1 / Q000235:genetics* / Q000276:immunology; D055610:Antigens, CD1d; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D015536:Down-Regulation; D005260:Female; D005786:Gene Expression Regulation; D007694:Killer Cells, Natural / Q000276:immunology; D008216:Lymphocytic Choriomeningitis / Q000276:immunology / Q000821:virology*; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D008264:Macrophages / Q000166:cytology / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012313:RNA / Q000235:genetics; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; D012313:RNA