title: Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles.
abstract: It is known that sphingomyelin (SM) content is higher in apolipoprotein B-containing particles (BLps) than in high density lipoproteins and that BLp levels, including chylomicrons and their remnant particles, are positively related to atherosclerosis. To evaluate the relationship between serum SM and postprandial remnant particle levels, we determined SM, triglyceride (TG), and cholesterol levels in serum and in remnant-like particles (RLPs) before and 3, 5, 7, and 10 h after a high-fat meal in 31 healthy subjects. We found that serum SM, like serum TG, was increased to its maximum 3 h after fat loading and then gradually decreased to basal levels after 10 h. More important, we determined that SM and TG levels in RLPs were parallel. Serum SM was positively correlated with serum TG (P <0.001), RLP SM (P <0.001), RLP TG (P <0.001), and RLP cholesterol (P <0.001) levels. It is our conclusion that serum SM is a marker for the clearance of RLPs.
authors.affiliation: Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY, USA. axelschlitt@gmx.net
authors.forename: Axel
authors.initials: A
authors.lastname: Schlitt
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Hojjati
authors.forename: Hans
authors.initials: H
authors.lastname: von Gizycki
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Lackner
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schwaab
authors.forename: Juergen
authors.initials: J
authors.lastname: Meyer
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Rupprecht
authors.forename: Xian-Cheng
authors.initials: XC
authors.lastname: Jiang
mesh_terms: D001055:Apolipoproteins B / Q000097:blood*; D001161:Arteriosclerosis; D015415:Biomarkers; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D002914:Chylomicrons / Q000378:metabolism; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism; D019518:Postprandial Period; D013109:Sphingomyelins / Q000097:blood*; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D008076:Cholesterol, HDL; D002914:Chylomicrons; D008075:Lipoproteins, HDL; D013109:Sphingomyelins; D014280:Triglycerides; D002784:Cholesterol