title: Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists.
abstract: The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.
authors.affiliation: Department of Neuroscience Research, GPRD R4MN, Abbott Laboratories, AP9a/216, Abbott Park, IL 60073-6123, USA. marlon.d.cowart@abbott.com.
authors.forename: Marlon
authors.initials: M
authors.lastname: Cowart
authors.forename: Robert
authors.initials: R
authors.lastname: Altenbach
authors.forename: Lawrence
authors.initials: L
authors.lastname: Black
authors.forename: Ramin
authors.initials: R
authors.lastname: Faghih
authors.forename: Chen
authors.initials: C
authors.lastname: Zhao
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Hancock
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000737:chemistry; D006633:Histamine Antagonists / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000737:chemistry; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D006633:Histamine Antagonists; D007093:Imidazoles; D018100:Receptors, Histamine H3; C029899:imidazole; C105430:benzofuran