title: [Interstitial fibrosis in cryptogenic organizing pneumonia could be a predictive factor of relapses].
abstract: BACKGROUND
  Cryptogenic organizing pneumonia (COP) is a clinicopathologic syndrome characterized by a good prognosis with steroid therapy, but frequent relapses when the dose of corticosteroid is reduced or stopped.
  
  
  METHODS
  The purpose of this study was to identify histopathologic features related to the relapse of COP. Six cases of COP that had been diagnosed using open lung biopsy were selected for evaluation. The 6 cases were put into two groups composed of 3 patients who relapsed and 3 who did not relapse. Their pathologic features were examined and compared.
  
  
  CONCLUSIONS
  Interstitial fibrosis of the lung parenchyma could correspond to histopathologic characteristics of relapses in COP.
authors.affiliation: Service de Pneumologie, Hôpital Pasteur, Centre Hospitalier et Universitaire de Nice, France. perrin.cp@chu-nice.fr
authors.forename: C
authors.initials: C
authors.lastname: Perrin
authors.forename: V
authors.initials: V
authors.lastname: Hofman
authors.forename: N
authors.initials: N
authors.lastname: Venissac
authors.forename: V
authors.initials: V
authors.lastname: Jullien
authors.forename: B
authors.initials: B
authors.lastname: Blaive
mesh_terms: D000328:Adult; D000368:Aged; D018549:Cryptogenic Organizing Pneumonia / Q000473:pathology*; D005260:Female; D006097:Granulation Tissue / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D008168:Lung / Q000473:pathology; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000473:pathology*; D012008:Recurrence