title: Recipient death during a live donor liver transplantation: who gets the "orphan" graft?
abstract: The limited availability of deceased organ donors, prolongation of waiting time, and increasing number of patients dying awaiting transplantation have contributed to the increased use of adult-to-adult living-donor liver transplant. In the event that the intended recipient dies after the donor graft has been procured but before it has been transplanted, what should be done with the graft? A structured, nine-item oral survey of 26 experts in liver transplantation was conducted in June and July 2003. Respondents were selected primarily because of their extensive experience with liver transplantation, especially adult-to-adult living-donor transplant. All respondents said the surgical team should try to use the available graft for another recipient. Twenty-one respondents believed consent from the donor or the donor's family was required for allocation, whereas 19% believed consent desirable but not required. Nine respondents recommended an allocation organization place the graft, whereas 17 respondents recommended placement within the donor hospital. Two of the respondents had previously encountered this situation, whereas four had experienced an intraoperative recipient death before procurement of a live donor graft. On the basis of the responses, we offer the following recommendations for handling orphan liver grafts: (1) obtain predonation informed consent from all donors that indicates what the donor would want to have done with the "orphan graft" in all cases of living-donor liver transplantation; (2) avoid the premature removal of the donor graft until the recipient hepatectomy and survival are likely; (3) if a live donor graft has been procured and cannot be transplanted into the intended recipient, and if informed consent has been obtained before the donor operation, the organ should be reallocated without delay to minimize cold ischemia time and maximize the utility of the graft.
authors.affiliation: Department of Surgery, University of Chicago, Chicago, Illinois, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Siegler
authors.forename: Mark
authors.initials: M
authors.lastname: Siegler
authors.forename: David C
authors.initials: DC
authors.lastname: Cronin
mesh_terms: D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000941:ethics*; D019520:Living Donors; D008297:Male; D009927:Tissue and Organ Procurement