[Experimental intraocular introduction of blood serum of patients with endophthalmitis].
Effects of blood serum from patients with endophthalmitis, who systematically received gentamicin at therapeutic dose, exerted on the retina of healthy rabbits were experimentally studied. A moderate toxic effect produced by gentamicin on the retina, when it was administered in the vitreous body of rabbits, was detected yet on day 1 of the experiment. Changes of retinal electrogenesis were aggravating and, beginning from day 7, there were noted profound changes of the functional activity in all retinal layers. According to the results, the blood serum from patients with endophthalmitis, who were systematically receiving gantamicin at therapeutic dose, does not virtually have any negative effect on the functional condition of the retina and can be used for intracavitary administration.
Gundarova
R A
RA
Zueva
M V
MV
Tsapenko
I V
IV
Bykov
V P
VP
Velichko
V A
VA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004596:Electroretinography; D009877:Endophthalmitis / Q000097:blood* / Q000188:drug therapy*; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D011817:Rabbits; D012160:Retina / Q000187:drug effects*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005839:Gentamicins