Signaling kinases modulated by 4-hydroxynonenal.
The interaction of 4-hydroxynonenal (HNE) with a variety of kinases variously involved in cell signaling is now a matter of active investigation. In particular, findings with regard to the effect of HNE on different components of the protein kinase C family and the mitogen-activated protein kinase complex already provide reliable indications of a potential role of this aldehyde as a cell signal messenger. Such a role appears further supported by the clear-cut evidence of up-regulation of receptor tyrosine kinases and down-regulation of the nuclear factor kappa B system, produced by HNE concentrations actually detectable in pathophysiology.
Leonarduzzi
Gabriella
G
Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, Turin, Italy.
Robbesyn
Fanny
F
Poli
Giuseppe
G
D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D015536:Down-Regulation; D006801:Humans; D051550:I-kappa B Kinase; D017346:Protein Serine-Threonine Kinases / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000187:drug effects* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects*; D015854:Up-Regulation
D000447:Aldehydes; D020794:Receptor Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; C496559:CHUK protein, human; D051550:I-kappa B Kinase; C496560:IKBKB protein, human; C496565:IKBKE protein, human; C027576:4-hydroxy-2-nonenal