title: Kappa III immunoglobulin light chain origin of localized orbital amyloidosis.
abstract: Isolated orbital amyloidosis is a rare condition in which intra-muscular deposits result in proptosis and restriction of eye movement. Previous reports have suggested an immunoglobulin origin of the amyloid fibrils, but this has not been proven biochemically. A case is presented in which initial unilateral orbital amyloidosis progressed to bilateral disease. Biochemical analysis of resected ocular muscle determined that the amyloid fibrils were derived from a kappa III immunoglobulin light chain. Questions of pathogenesis and tissue tropism are considered.
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202-5121, USA.
authors.forename: Kamran
authors.initials: K
authors.lastname: Hamidi Asl
authors.forename: Juris J
authors.initials: JJ
authors.lastname: Liepnieks
authors.forename: William R
authors.initials: WR
authors.lastname: Nunery
authors.forename: Masahide
authors.initials: M
authors.lastname: Yazaki
authors.forename: Merrill D L
authors.initials: MD
authors.lastname: Benson
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000473:pathology*; D005094:Exophthalmos / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains; D009801:Oculomotor Muscles / Q000000981:diagnostic imaging / Q000473:pathology*; D009916:Orbital Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D007145:Immunoglobulin kappa-Chains