Fingering IL-12 with apoptotic cells.
Exposure of phosphatidylserine on the surface of apoptotic cells contributes to their removal in situ by quiet, noninflammatory, and nonimmunogenic mechanisms. In this issue of Immunity, describe a completely new mechanism for this effect that involves a novel zinc finger nuclear factor that inhibits IL-12 production.
Henson
Peter M
PM
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
D017209:Apoptosis; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D010766:Phosphorylation; D012097:Repressor Proteins / Q000502:physiology*; D016335:Zinc Fingers
C072278:GCFC2 protein, human; D012097:Repressor Proteins; D018664:Interleukin-12