Synthesis and anti-mildew activity of 5-(2-aroyl)aryloxymethyl-2-phenyl-1 ,3,4-oxadiazoles against downy mildew of pearl millet.
A manipulatively simple, rapid, high-yielding and environmentally benign method for the integration of a heterocyclic ring, 1,3,4-oxadiazole, at the benzophenone nucleus has been achieved through intramolecular cyclization of substituted aroylaryloxyacetohydrazides to substituted 5-(2-aroyl)aryloxymethyl-2-phenyl-1,3,4-oxadiazoles under solventless 'dry' conditions using montmorillonite K10 clay and microwave irradiation. A comparison is made of the microwave-accelerated reaction with conventional heating conditions. Certain of the derivatives tested showed significant anti-mildew activity against Sclerospora graminicola (Sacc) Schroeter, the downy mildew pathogen of pearl millet.
Khanum
Shaukath A
SA
Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore-570 005, India.
Shashikanth
Sheena
S
Sudha
Belgur S
BS
Deepak
Saligrama A
SA
Shetty
Huntrike S
HS
D001681:Biological Assay; D006361:Heating / Q000379:methods; D008872:Microwaves; D009868:Oomycetes / Q000187:drug effects*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D031782:Pennisetum / Q000382:microbiology*; D010935:Plant Diseases / Q000382:microbiology
D010069:Oxadiazoles