Pancreatic schwannoma. A case report and review of the literature.
BACKGROUND
Pancreatic schwannomas are rare neoplasms. These tumors vary in size and two thirds are partially cystic which grossly mimic pancreatic cystic lesions. Computed tomography and magnetic resonance imaging are the primary initial imaging modalities. Definitive diagnosis is typically made at the time of laparotomy following biopsy. Surgical resection is the mainstay of treatment.


METHODS
A 69-year-old woman presented with abdominal pain in the epigastric and left upper quadrant. The patient had no systemic symptom and laboratory results including tumor markers were negative. A CT scan of the abdomen showed a 5 cm mass arising from the head of the pancreas. Needle biopsy revealed a mass consistent with schwannoma. At laparotomy, a large pancreatic head mass was found to encase the superior mesenteric artery, and portal vein confluence. Frozen biopsy showed schwannoma. Curative resection was deferred due to extensive vascular involvement and favorable tumor biology. A gastrojejunostomy was performed and radiation therapy was instituted post-operatively.


CONCLUSIONS
Only 24 cases of pancreatic schwannoma had been previously reported. Definitive diagnosis is obtained with routine histology. Most tumors are benign and surgical resection is curative. The role of radiation therapy in the management of unresectable tumors is still unclear.
Bui
Trung D
TD
Department of General Surgery, UCI Medical Center, Orange, CA, USA. buitd@uci.edu
Nguyen
Tien
T
Huerta
Sergio
S
Gu
Mai
M
Hsiang
David
D
D015746:Abdominal Pain / Q000209:etiology; D000368:Aged; D019160:Endosonography; D005260:Female; D006801:Humans; D009325:Nausea / Q000209:etiology; D009442:Neurilemmoma / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed