title: Chemical graft polymerization of sulfobetaine monomer on polyurethane surface for reduction in platelet adhesion.
abstract: Surface modification is an effective way to improve the hemocompatibility and remain bulk properties of biomaterials. Recently, polymer tailored with zwitterions was found having good blood compatibility. In this study, the zwitterionic monomer of sulfobetaine was graft polymerized onto polyurethane (PU) surface in a three-step heterogenous system through the vinyl bonds of acrylic acid (AA) or hydroxyethyl methacrylate (HEMA), which was immobilized with hexamethylene diisocyanate (HDI) beforehand. First, PU was activated with isocyanate groups using HDI as coupling agent. Second, AA or HEMA was introduced through reaction of AA or HEMA with NCO groups bonded on PU surface. Last, zwitterionic monomer of sulfobetain was graft polymerized with vinyl group of AA or HEMA using AIBN as polymerization initiator. The reaction process was monitored with ATR-IR spectra and XPS spectra. Variation of graft yield with temperature and monomer feed concentration was investigated and feasible conditions were optimized. The wettability of films was investigated by water contact angle measurement and water absorbance. Platelet adhesion experiment was conducted as a preliminary test to confirm the improved blood compatibility of PU. The number of platelets adhering to PU decreased greatly comparing with the originals after 1 and 3 h of contact with human plate-rich plasma (PRP).
authors.affiliation: College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P.R. China. alchem@eyou.com
authors.forename: Jiang
authors.initials: J
authors.lastname: Yuan
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.forename: Sicong
authors.initials: S
authors.lastname: Lin
mesh_terms: D000179:Acrylates / Q000737:chemistry; D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry; D001672:Biocompatible Materials; D003485:Cyanates / Q000737:chemistry; D004577:Electron Probe Microanalysis; D006801:Humans; D007259:Infrared Rays; D017953:Isocyanates / Q000737:chemistry; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D010973:Platelet Adhesiveness; D011108:Polymers / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors
chemical_list: D000179:Acrylates; D001672:Biocompatible Materials; D003485:Cyanates; D017953:Isocyanates; D008689:Methacrylates; D011108:Polymers; D011140:Polyurethanes; C015262:1,6-hexamethylene diisocyanate; D001622:Betaine; C005044:hydroxyethyl methacrylate; C483727:sulfobetaine; C036658:acrylic acid