title: Circulating biomarkers from tumour bulk to tumour machinery: promises and pitfalls.
abstract: In this paper, we provide a working classification for circulating biomarkers according to their potential clinical application. We broadly divided biomarkers into four groups: (i) biomarkers of cancer risk, (ii) biomarkers of tumour-host interactions, (iii) biomarker of tumour burden, and (iv) function-related biomarkers. We hope this classification will provide a framework to which the results of future studies can be added. We also discuss the promises and pitfalls in the optional use of biomarkers in oncology.
authors.affiliation: Associazione ABO, c/o Centro Regionale Indicatori Biochimici di Tumore, Ospedale Civile, Venice 30122, Italy. cnabo@provincia.venezia.it
authors.forename: M
authors.initials: M
authors.lastname: Gion
authors.forename: M G
authors.initials: MG
authors.lastname: Daidone
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000145:classification / Q000502:physiology; D005544:Forecasting; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis*; D011379:Prognosis; D012307:Risk Factors; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor