Metronidazole for the prevention of dry socket after removal of partially impacted mandibular third molar: a randomised controlled trial.
We randomised 119 patients who had been referred for removal of partially impacted mandibular third molars to be given either metronidazole 1600 mg or placebo as a single dose 45 min before operation. Ten of the fifty-nine patients who were given metronidazole and 13 of the 60 given placebo developed dry sockets. Two variables were significantly associated with the development of a dry socket: pericoronitis and oral contraceptives.
Bergdahl
M
M
Department of Odontology, Faculty of Medicine and Odontology, Umeå University, Umeå, Sweden.
Hedström
L
L
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D003276:Contraceptives, Oral / Q000009:adverse effects; D004311:Double-Blind Method; D004368:Dry Socket / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008334:Mandible; D008795:Metronidazole / Q000008:administration & dosage*; D008964:Molar, Third / Q000601:surgery*; D010497:Pericoronitis / Q000150:complications; D011300:Preoperative Care; D018709:Statistics, Nonparametric; D014081:Tooth Extraction / Q000009:adverse effects*; D014095:Tooth, Impacted / Q000150:complications / Q000601:surgery*
D000890:Anti-Infective Agents; D003276:Contraceptives, Oral; D008795:Metronidazole