title: Study of hematological and biochemical parameters in runners completing a standard marathon.
abstract: OBJECTIVE
  To study hematological and biochemical parameters prospectively in runners completing a standard 42.2-km marathon run. To determine the incidence of hyponatremia in runners, and whether consumption of nonsteroidal anti-inflammatory medications (NSAIDs) was associated with alterations in serum biochemical parameters.
  
  
  METHODS
  Observational cohort study.
  
  
  METHODS
  City of Christchurch (New Zealand) Marathon, June 2002.
  
  
  METHODS
  One hundred fifty-five of the 296 athletes entered in the 2002 City of Christchurch Marathon were enrolled in the study.
  
  
  METHODS
  Athletes were weighed at race registration and immediately after the race. Blood was drawn postrace for measurement of serum sodium, potassium, creatinine, and urea concentrations and for hematological analysis (hemoglobin concentration, hematocrit, leukocyte distribution).
  
  
  RESULTS
  Complete data sets including prerace and postrace weights, and postrace hematological and biochemical analyses were collected on 134 marathon finishers. Postrace serum sodium concentrations were directly related to changes in body weight (P < 0.0001). There were no cases of biochemical or symptomatic hyponatremia. Thirteen percent of runners had taken an NSAID in the 24 hours prior to the race. Mean values for serum creatinine (P = 0.03) and serum potassium (P = 0.007) concentrations were significantly higher in runners who had taken an NSAID. No athlete who had taken an NSAID had a postrace serum creatinine concentration less than 0.09 mmol/L. Ninety-eight percent of runners had a postrace leukocytosis (mean white cell count, 18.97 b/L), of which the major component was a raised neutrophil count (mean neutrophil count, 15.69 b/L).
  
  
  CONCLUSIONS
  This study found no cases of hyponatremia in runners completing a standard distance marathon. This finding relates to a marathon run under ideal conditions (minimal climatic stress) and in which there were fewer aid stations (every 5 km) than is common in North American marathons (every 1.6 km). Also, aggressive hydration practices were not promoted. Consumption of NSAIDs in the 24 hours prior to distance running was associated with altered renal function.
authors.affiliation: SportsMed, Christchurch, New Zealand. stevenlyn@ozemail.com.au
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Reid
authors.forename: Dale B
authors.initials: DB
authors.lastname: Speedy
authors.forename: John M D
authors.initials: JM
authors.lastname: Thompson
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Noakes
authors.forename: Guy
authors.initials: G
authors.lastname: Mulligan
authors.forename: Tony
authors.initials: T
authors.lastname: Page
authors.forename: Robert G D
authors.initials: RG
authors.lastname: Campbell
authors.forename: Chris
authors.initials: C
authors.lastname: Milne
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001774:Blood Chemical Analysis; D015331:Cohort Studies; D003404:Creatinine / Q000032:analysis / Q000378:metabolism; D005260:Female; D006400:Hematocrit; D006403:Hematologic Tests; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000453:epidemiology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance / Q000187:drug effects / Q000502:physiology*; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology*; D011336:Probability; D011446:Prospective Studies; D012307:Risk Factors; D012420:Running / Q000502:physiology*; D012737:Sex Factors; D014883:Water-Electrolyte Imbalance / Q000175:diagnosis / Q000453:epidemiology; D015431:Weight Loss
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003404:Creatinine