title: A concise asymmetric synthesis of the ADE fragment of nakadomarin A.
abstract: The ADE fragment of nakadomarin A has been synthesized in nine linear steps from commercial material. The key transformation is an asymmetric azomethine ylide [1,3]-dipolar cycloaddition to establish the AD-spirocyclic system containing three of the four stereocenters of the natural product. [reaction: see text]
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors.forename: Kateri A
authors.initials: KA
authors.lastname: Ahrendt
authors.forename: Robert M
authors.initials: RM
authors.lastname: Williams
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis
chemical_list: D001391:Azo Compounds; D002243:Carbolines; D013141:Spiro Compounds; C476640:nakadomarin A; C001825:azomethane