Histamine H3 receptor agonists.
The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
De Esch
I J P
IJ
De Novo Pharmaceuticals, Compass House, Vision Park Histon, Cambridge, UK. ideesch@few.vu.nl
Belzar
K J
KJ
D000818:Animals; D017442:Histamine Agonists / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D017442:Histamine Agonists; D008024:Ligands; D018100:Receptors, Histamine H3