Angiogenic response induced by acellular aortic matrix in vivo.
In this study, we investigated the angiogenic response induced by acellular aortic matrices implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. Results showed that acellular matrices were able to induce a strong angiogenic response comparable to that of fibroblast growth factor 2 (FGF-2), a well-known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF-2 or transforming growth factor beta 1 (TGF-beta1) were added to the matrices and inhibited by the addition of an anti-FGF-2 or anti-TGF-beta1 antibodies. The response may be considered dependent on a direct angiogenic effect exerted by the matrices and in part also by the presence of FGF-2 and TGF-beta1 in the acellular matrices.
Conconi
Maria Teresa
MT
Department of Pharmaceutical Sciences, University of Padua, Padua, Italy.
Nico
Beatrice
B
Mangieri
Domenica
D
Tommasini
Mara
M
di Liddo
Rosa
R
Parnigotto
Pier Paolo
PP
Nussdorfer
Gastone G
GG
Ribatti
Domenico
D
D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D016222:Fibroblast Growth Factor 2 / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D013552:Swine; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000276:immunology / Q000494:pharmacology; D053773:Transforming Growth Factor beta1; D019737:Transplants
D043925:Angiogenesis Inducing Agents; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2