title: Syncope Evaluation in the Emergency Department Study (SEEDS): a multidisciplinary approach to syncope management.
abstract: BACKGROUND
  The primary aim and central hypothesis of the study are that a designated syncope unit in the emergency department improves diagnostic yield and reduces hospital admission for patients with syncope who are at intermediate risk for an adverse cardiovascular outcome.
  
  
  RESULTS
  In this prospective, randomized, single-center study, patients were randomly allocated to 2 treatment arms: syncope unit evaluation and standard care. The 2 groups were compared with chi2 test for independence of categorical variables. Wilcoxon rank sum test was used for continuous variables. Survival was estimated with the Kaplan-Meier method. One hundred three consecutive patients (53 women; mean age 64+/-17 years) entered the study. Fifty-one patients were randomized to the syncope unit. For the syncope unit and standard care patients, the presumptive diagnosis was established in 34 (67%) and 5 (10%) patients (P<0.001), respectively, hospital admission was required for 22 (43%) and 51 (98%) patients (P<0.001), and total patient-hospital days were reduced from 140 to 64. Actuarial survival was 97% and 90% (P=0.30), and survival free from recurrent syncope was 88% and 89% (P=0.72) at 2 years for the syncope unit and standard care groups, respectively.
  
  
  CONCLUSIONS
  The novel syncope unit designed for this study significantly improved diagnostic yield in the emergency department and reduced hospital admission and total length of hospital stay without affecting recurrent syncope and all-cause mortality among intermediate-risk patients. Observations from the present study provide benchmark data for improving patient care and effectively utilizing healthcare resources.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA. wshen@mayo.edu
authors.forename: Win K
authors.initials: WK
authors.lastname: Shen
authors.forename: Wyatt W
authors.initials: WW
authors.lastname: Decker
authors.forename: Peter A
authors.initials: PA
authors.lastname: Smars
authors.forename: Deepi G
authors.initials: DG
authors.lastname: Goyal
authors.forename: Ann E
authors.initials: AE
authors.lastname: Walker
authors.forename: David O
authors.initials: DO
authors.lastname: Hodge
authors.forename: Jane M
authors.initials: JM
authors.lastname: Trusty
authors.forename: Karen M
authors.initials: KM
authors.lastname: Brekke
authors.forename: Arshad
authors.initials: A
authors.lastname: Jahangir
authors.forename: Peter A
authors.initials: PA
authors.lastname: Brady
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Munger
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: Gersh
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Hammill
authors.forename: Robert L
authors.initials: RL
authors.lastname: Frye
mesh_terms: D000368:Aged; D000553:Ambulatory Care / Q000706:statistics & numerical data; D004562:Electrocardiography; D004632:Emergency Medical Services / Q000379:methods; D004636:Emergency Service, Hospital; D023381:Endpoint Determination; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D018570:Risk Assessment; D013575:Syncope / Q000175:diagnosis* / Q000191:economics / Q000401:mortality; D018667:Tilt-Table Test