title: Mortality following non-ST elevation acute coronary syndrome: 4 years follow-up of the PRAIS UK Registry (Prospective Registry of Acute Ischaemic Syndromes in the UK).
abstract: OBJECTIVE
  To present information on long-term prognosis and risk factors following an admission with non-ST elevation acute coronary syndrome.
  
  
  METHODS
  A cohort of 653 patients was followed for mortality and causes of death using data from the UK Office of National Statistics (ONS). Cox proportional hazards model was used to identify the prognostic factors.
  
  
  RESULTS
  Overall survival at a maximum follow-up of 45 months was 77.8% (95% CI 74.1-81.1%). Seventy-three per cent of the deaths were clearly due to a cardiovascular cause. Age, male gender, heart failure, ST depression or bundle branch block were all associated with higher short- and long-term risk. Taking aspirin or having a revascularization procedure, over the period of six months following initial hospitalisation were both associated with a lower long-term risk.
  
  
  CONCLUSIONS
  Non-ST elevation acute coronary syndromes carry a high risk of death over a 4-year period. Conventional risk factors can predict both short- and long-term risk. More invasive management and the use of evidence-based therapies appear to be associated with a lower risk.
authors.affiliation: Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK. a.taneja@rbh.nthames.nhs.uk
authors.forename: Anil K
authors.initials: AK
authors.lastname: Taneja
authors.forename: Julian
authors.initials: J
authors.lastname: Collinson
authors.forename: Marcus D
authors.initials: MD
authors.lastname: Flather
authors.forename: Ameet
authors.initials: A
authors.lastname: Bakhai
authors.forename: Diego Perez
authors.initials: DP
authors.lastname: de Arenaza
authors.forename: Duolao
authors.initials: D
authors.lastname: Wang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Adgey
authors.forename: Keith A A
authors.initials: KA
authors.lastname: Fox
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000401:mortality; D001241:Aspirin / Q000627:therapeutic use; D015331:Cohort Studies; D001026:Coronary Artery Bypass / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000401:mortality*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin