title: Creutzfeldt-Jakob disease presenting as refractory nonconvulsive status epilepticus.
abstract: A 70-year-old woman was admitted to the intensive care unit with refractory nonconvulsive status epilepticus. Extensive evaluation including neuroimaging and cerebrospinal fluid examination was unrevealing. Brain biopsy revealed spongiosis, and prion disease was confirmed by immunostaining, providing the diagnosis of Creutzfeldt-Jakob disease.
authors.affiliation: Department of Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY, USA. Jshapiro@chpnet.org
authors.forename: Janet M
authors.initials: JM
authors.lastname: Shapiro
authors.forename: Adil
authors.initials: A
authors.lastname: Shujaat
authors.forename: Jill
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Chen
mesh_terms: D000368:Aged; D001037:Aphasia / Q000209:etiology; D001706:Biopsy; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control; D003422:Critical Care / Q000379:methods; D003937:Diagnosis, Differential; D018450:Disease Progression; D004569:Electroencephalography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007118:Immunoassay; D017053:Infection Control / Q000379:methods; D010291:Paresis / Q000209:etiology; D016133:Polymerase Chain Reaction; D035583:Rare Diseases; D013226:Status Epilepticus / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*