CART peptides: modulators of mesolimbic dopamine, feeding, and stress.
CART peptides have been shown to be peptide neurotransmitters and endocrine factors in a series of cumulative studies over the past eight years or so. This brief review touches on three aspects of CART: CART as a mediator or modulator of mesolimbic dopamine, CART's regulation by glucocorticoids, and CART as a regulator of feeding, satiety, and body weight. There have been several recent reviews and publications on various aspects of CART peptides. These aspects include the sequence and numbering of the peptides, and their structure, processing, and roles in various physiologic processes.
Dominguez
Geraldina
G
Yerkes National Primate Research Center, Division of Neuroscience, Emory University, Atlanta, Georgia 30329, USA.
Vicentic
Alexandra
A
Del Giudice
Emanuele Miraglia
EM
Jaworski
Jason
J
Hunter
Richard G
RG
Kuhar
Michael J
MJ
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D013312:Stress, Physiological / Q000378:metabolism*; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
D009419:Nerve Tissue Proteins; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D004298:Dopamine