title: [Vitamin D receptor polymorphism in the group of postmenopausal women with low bone mineral density].
abstract: OBJECTIVE
  Osteoporosis is a multifactoral disease with aetiology depending from the hormonal, environmental, and genetic factors. One of the suggested candidate gene involved in the pathogenesis is the polymorphic gene encoding for vitamin D receptor (VDR). VDR polymorphism was connected with bone mineral density (BMD) and correlated with onset of osteoporosis. The goal of our study was to determine the role of BsmI polymorphism of VDR gene in the group of postmenopausal women with low bone mineral density.
  
  
  METHODS
  We have analysed the group of 34 postmenopausal women. The DNA analysis was performed using PCR/RFLP (polymerase chain reaction/restriction fragment length polymorphism) assays.
  
  
  RESULTS
  In our investigation we have observed statistically higher frequency of B allele (48.5% vs. 41.2%), the lower frequency of b allele (51.5% vs. 58.8%) and bb genotype (8.8% vs. 42.5%) in the investigated group of postmenopausal women with low BMD.
  
  
  CONCLUSIONS
  Our observations could suggest the important role of B allele of the VDR gene in the pathogenesis of osteoporosis in the group of women with low mineral density and possible protective role of b allele in this disease.
authors.affiliation: Klinika Perinatologii AM w Poznaniu.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Seremak-Mrozikiewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Drews
authors.forename: Anna
authors.initials: A
authors.lastname: Dańska
authors.forename: Marek
authors.initials: M
authors.lastname: Spaczyński
authors.forename: Tomasz
authors.initials: T
authors.lastname: Opala
authors.forename: Przemysław M
authors.initials: PM
authors.lastname: Mrozikiewicz
mesh_terms: D000328:Adult; D000375:Aging / Q000235:genetics; D000483:Alleles; D015519:Bone Density / Q000235:genetics*; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017698:Postmenopause / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific