title: Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma.
abstract: OBJECTIVE
  Primary open angle glaucoma (POAG) is a major cause of late onset visual failure of unknown etiology. Recent genetic association studies have implicated the apolipoprotein E (APOE) gene in the pathophysiology of primary open angle glaucoma, but there have been conflicting findings.
  
  
  METHODS
  To resolve this issue we studied 140 cases and 73 controls that were carefully phenotyped, and used a logistic regression model to simultaneously analyze the effect of apolipoprotein E genotype and functional polymorphisms in the apolipoprotein E gene promoter while controlling for potentially confounding variables.
  
  
  RESULTS
  We found no evidence of an association between the apolipoprotein E promoter region polymorphisms and primary open angle glaucoma.
  
  
  CONCLUSIONS
  Apolipoprotein E promoter polymorphisms are unlikely to have a major impact on the pathophysiology of primary open angle glaucoma.
authors.affiliation: Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ressiniotis
authors.forename: Philip G
authors.initials: PG
authors.lastname: Griffiths
authors.forename: Michael
authors.initials: M
authors.lastname: Birch
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Keers
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Chinnery
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D017931:DNA Primers