Cachexia in malaria and heart failure: therapeutic considerations in clinical practice.
Cachexia is an independent prognostic marker of survival in many chronic diseases including heart failure and malaria. Morbidity and mortality from malaria is high in most of the third world where it presents a very challenging public health problem. Malaria may present in the UK as fever in the returning traveller or as fever in overseas visitors. How and why cachexia develops in malaria in a manner similar to the cachexia of chronic heart failure and the treatment strategies that would alter outcomes in both diseases are discussed in this review.
Onwuamaegbu
M E
ME
Department of Clinical Cardiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK. drmeto@doctors.net.uk
Henein
M
M
Coats
A J
AJ
D002100:Cachexia / Q000209:etiology* / Q000401:mortality; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism; D006333:Heart Failure / Q000150:complications* / Q000401:mortality; D006801:Humans; D008055:Lipids / Q000097:blood; D008288:Malaria / Q000150:complications* / Q000276:immunology / Q000401:mortality; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha