[Clinical study on respiratory mechanics of synchronized intermittent mandatory ventilation in premature infants with respiratory failure].
OBJECTIVE
To evaluate the clinical significance of synchronized intermittent mandatory ventilation (SIMV) in prematures infants necessitating assistant ventilation.


METHODS
Forty-two premature infants were studied in whom SIMV was used in 24 and intermittent mandatory ventilation (IMV) was used in 18. The parameters of fractional concentration of inspired oxygen (FiO(2)), peak inspiratory pressure (PIP), expiratory tidal volume (V(Texp)), oxygen index (OI), compliance of the respiratory system (Crs) and airway resistance (Raw) were compared. The frequency of administration of sedatives and incidence rate of complications were also compared between two groups.


RESULTS
In SIMV group, PIP, V(Texp), Raw and Crs were significant better after 2 hours ventilation (all P<0.05). There were significant difference in FiO(2) after 12 hours and OI at 24 hours in two groups. They were better in SIMV group. Sedatives were less used in SIMV group than IMV group (P<0.05).


CONCLUSIONS
In premature infants, SIMV could reduce FiO(2), PIP, OI, Raw and improve V(Texp), Crs more rapidly when assistant ventilation is necessary. The sedatives are used less in patients on SIMV.
Wang
Shao-hua
SH
NICU, Futian Women and Children Health Institute, Shenzhen 518045, Guangdong, China.
Yang
Jun
J
Chen
Shao-bo
SB
Kuang
Feng-wu
FW
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods*; D012131:Respiratory Insufficiency / Q000628:therapy*; D015656:Respiratory Mechanics