title: SRP meets the ribosome.
abstract: Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.
authors.affiliation: Biochemie-Zentrum der Universität Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.
authors.forename: Klemens
authors.initials: K
authors.lastname: Wild
authors.forename: Mario
authors.initials: M
authors.lastname: Halic
authors.forename: Irmgard
authors.initials: I
authors.lastname: Sinning
authors.forename: Roland
authors.initials: R
authors.lastname: Beckmann
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006160:Guanosine Triphosphate / Q000737:chemistry; D006801:Humans; D008954:Models, Biological; D014176:Protein Biosynthesis; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D012270:Ribosomes / Q000378:metabolism / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D018271:Signal Recognition Particle / Q000502:physiology; D015398:Signal Transduction; D016944:Sulfolobus / Q000502:physiology
chemical_list: C069268:SRP54 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D018271:Signal Recognition Particle; D006160:Guanosine Triphosphate