A new immune-competent animal model of mucosally derived squamous cell carcinoma.
OBJECTIVE
To develop an immune-competent animal model for mucosally derived squamous cell carcinoma (SCCA).


METHODS
Fifteen Fischer 344 rats were inoculated with 1, 2, 5, 10, or 20 x 10(6) FAT7 cells in their flanks. The animals were observed for tumor growth and metastasis.


RESULTS
All animals developed tumors that grew exponentially. Pulmonary metastases developed in all animals and 13% developed lymph node metastases.


CONCLUSIONS
The FAT7 flank tumor in Fischer 344 rats is a new animal model that closely resembles the behavior of human mucosal head and neck cancer.


CONCLUSIONS
The existence of an immune-competent, mucosally derived, and reliable animal model of SCCA that somewhat resembles human head and neck SCCA gives the opportunity to perform immune-modulating experiments on head and neck cancer in these animals.


METHODS
B-3.
Djalilian
Hamid R
HR
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA.
Lessan
Khashayar
K
Grami
Vahid
V
Pambuccian
Stefan E
SE
Spellman
Stephen R
SR
Low
Walter C
WC
Hall
Walter A
WA
Ondrey
Frank G
FG
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000096:biosynthesis; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism*; D007121:Immunocompetence; D023421:Models, Animal; D009154:Mutation; D009297:Nasal Mucosa; D051381:Rats; D016211:Transforming Growth Factor alpha / Q000096:biosynthesis
D016211:Transforming Growth Factor alpha; D066246:ErbB Receptors