title: Genetic confirmation of quinine-resistant Plasmodium falciparum malaria followed by postmalaria neurological syndrome in a traveler from Mozambique.
abstract: A case of quinine-resistant Plasmodium falciparum malaria, followed by a postmalaria neurological syndrome and a recurrence episode, is described. Genetic characterization of the P. falciparum isolate obtained by analysis of msp1 and msp2 amplicons revealed the coexistence of two genotypes causing the first malaria episode and the presence of a unique isolate responsible for the recurrence.
authors.affiliation: Istituto Nazionale per le Malattie Infettive Lazzo Spallanzani, Rome, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Palmieri
authors.forename: Nicola
authors.initials: N
authors.lastname: Petrosillo
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Paglia
authors.forename: Aristide
authors.initials: A
authors.lastname: Conte
authors.forename: Delia
authors.initials: D
authors.lastname: Goletti
authors.forename: Leopoldo Paolo
authors.initials: LP
authors.lastname: Pucillo
authors.forename: Michela
authors.initials: M
authors.lastname: Menegon
authors.forename: Anna
authors.initials: A
authors.lastname: Sannella
authors.forename: Carlo
authors.initials: C
authors.lastname: Severini
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Majori
mesh_terms: D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D016779:Malaria, Cerebral / Q000150:complications / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000150:complications / Q000469:parasitology*; D008297:Male; D009073:Mozambique; D010963:Plasmodium falciparum / Q000145:classification* / Q000187:drug effects* / Q000235:genetics; D011803:Quinine / Q000494:pharmacology*; D012008:Recurrence; D014195:Travel
chemical_list: D000962:Antimalarials; D011803:Quinine; D007770:L-Lactate Dehydrogenase