A comparative study of the interaction of two structurally analogue ruthenium(II) complexes with DNA.
The binding of the ruthenium(II) complexes of [Ru(bpy)2(CAIP)]Cl2 and [Ru(bpy)2(HCIP)]Cl2 (where bpy=2,2'-bipyridine, CAIP=4-carboxyl-imidado[4,5-f][1,10]-phenanthroline, HCIP=3-hydroxyl-4-carboxyl-imidado[4,5-f][1,10]-phenanthroline) to calf thymus DNA (ct-DNA) has been investigated with UV-visible and emission spectroscopy, steady-state emission quenching, and viscosity measurements. The experimental results indicate that the two complexes bind to ct-DNA through an intercalative mode and [Ru(bpy)2(HCIP)]2+ intercalates into DNA more deeply than [Ru(bpy)2(CAIP)]2+ does.
Bai
Guang-Yao
GY
Department of Chemistry, Beijing Normal University, Beijing 100875, China.
Dong
Bin
B
Lü
Yuan-Yuan
YY
Wang
Ke-Zhi
KZ
Jin
Lin-Pei
LP
Gao
Li-Hua
LH
D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007364:Intercalating Agents / Q000737:chemistry; D049449:Luminescence; D015394:Molecular Structure; D010618:Phenanthrolines / Q000737:chemistry; D012428:Ruthenium / Q000378:metabolism*; D012996:Solutions / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014783:Viscosity
D007364:Intercalating Agents; D010618:Phenanthrolines; D012996:Solutions; D012428:Ruthenium; D004247:DNA; C427203:calf thymus DNA