(2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-beta-D-ribofuranos-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide.
The title compound, C(19)H(18)F(2)IO(6)P, prepared as a potential antiviral and anticancer agent from 3-methylsalicylchlorophosphane and 1-(2,4-difluoro-5-iodophenyl)-2-deoxy-beta-D-ribofuranose, is one of a 1:1 mixture of two diastereomers. The diastereomers differ in their configuration, S or R, at the asymmetric phosphorus center. X-Ray crystallographic analysis of the title compound has determined the absolute configuration at the asymmetric P center to be S.
Ohkura
Kazue
K
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu Hokkaido 061-0293, Japan. ohkura@hoku-iryo-u.ac.jp
Sun
Wei Yan
WY
Seki
Koh-ichi
K
Knaus
Edward E
EE
Wiebe
Leonard I
LI
D000970:Antineoplastic Agents / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009005:Monosaccharides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
C500659:(2S)-2-(1-(2,4-difluoro-5-iodophenyl)-2-deoxy-beta-D-ribofuranos-5-yloxy)-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D007202:Indicators and Reagents; D009005:Monosaccharides; D009943:Organophosphorus Compounds