title: [Evaluation of intra-arterial infusion chemotherapy associated with radiotherapy for two cases of local recurrence of rectal cancer].
abstract: We evaluated the effect of intra-arterial infusion chemotherapy associated with radiotherapy for two cases of local recurrence of rectal cancer. We performed an intra-arterial infusion chemotherapy (5-FU was injected continuously: 250 mg/day/body x 28 days, CDDP was injected weekly: 5 mg/day x 5 days) associated with radiotherapy (2-3 Gy/day x 20-30 days) for local recurrence of rectal cancer with the aim of pain-relief. Both patients markedly tended to feel less pain after the radiotherapy. Radiotherapy has been useful for pain-relief of the localized bone metastasis. The present intra-arterial infusion chemotherapy associated with radiotherapy was a possible local therapy for local recurrence of rectal cancer in the pelvis. Although the survival benefit depends on the presence of other site of recurrence, this procedure is useful for the improvement of QOL by relieving the pain of the patients.
authors.affiliation: Dept. of Surgery, Tsubame Rosai Hospital.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kiyonaga
authors.forename: Kaoru
authors.initials: K
authors.lastname: Miyashita
authors.forename: Naoki
authors.initials: N
authors.lastname: Okumura
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Morioka
authors.forename: Kikuo
authors.initials: K
authors.lastname: Aizawa
authors.forename: Mieko
authors.initials: M
authors.lastname: Tsuchida
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil