title: A recurrent chromosome 4 marker in primary squamous cell lung cancer.
abstract: A sample of eight primary lung tumors histologically identified as squamous cell type carcinomas (SQC) were cytogenetically analyzed after a short-term (7 days) culture. Several numerical and structural abnormalities were observed. As G-banding analysis is unable to fully characterize complex marker chromosomes, we applied the fluorescence chromosome painting technique to identify one as a marker derived from a chromosome 4 that has not been described until now. We found it in half of the analyzed cases.
authors.affiliation: Departamento de Citogenética, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia 3318, C.P. 11300 Montevideo, Uruguay. abmg@iibce.edu.uy
authors.forename: Adriana Beatriz
authors.initials: AB
authors.lastname: Mimbacas
authors.forename: José Horacio
authors.initials: JH
authors.lastname: Cardoso
mesh_terms: D002871:Chromosome Banding; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D018307:Neoplasms, Squamous Cell / Q000235:genetics / Q000473:pathology*; D014407:Tumor Cells, Cultured
chemical_list: D005819:Genetic Markers