Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration.
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS in the mice urine. The identification of 2C-B metabolites may give important clues for the biological and toxicological effects of this drug of abuse and provides new important data for forensic analysis on samples taken from 2C-B abusers.
Carmo
Helena
H
REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto. Rua Aníbal Cunha 164, 4050-047 Porto, Portugal. helenacarmo@ff.up.pt
de Boer
Douwe
D
Remião
Fernando
F
Carvalho
Félix
F
dos Reys
Lesseps A
LA
de Lourdes Bastos
Maria
M
D000818:Animals; D015198:Designer Drugs / Q000378:metabolism*; D004118:Dimethoxyphenylethylamine / Q000031:analogs & derivatives* / Q000378:metabolism*; D005554:Forensic Medicine; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D051379:Mice
D015198:Designer Drugs; D004118:Dimethoxyphenylethylamine; C079321:2-(4-bromo-2,5-dimethoxyphenyl)ethylamine