title: Safety and efficacy of stereotactic radiosurgery for tumors of the spine.
abstract: OBJECTIVE
  The extension of stereotactic radiosurgery treatment of tumors of the spine has the potential to benefit many patients. As in the early days of cranial stereotactic radiosurgery, however, dose-related efficacy and toxicity are not well understood. The authors report their initial experience with stereotactic radiosurgery of the spine with attention to dose, efficacy, and toxicity.
  
  
  METHODS
  All patients who underwent stereotactic radiosurgery of the spine were treated using the Novalis unit at Westchester Medical Center between December 2001 and January 2004 are included in a database consisting of demographics on disease, dose, outcome, and complications. A total of 31 patients (12 men, 19 women; mean age 61 years, median age 63 years) received treatment for 35 tumors. Tumor types included 26 metastases (12 lung, nine breast, five other) and nine primary tumors (four intradural, five extradural). Thoracic tumors were most common (17 metastases and four primary) followed by lumbar tumors (four metastases and four primary). Lesions were treated to the 85 to 90% isodose line with spinal cord doses being less than 50%. The dose per fraction and total dose were selected on the basis of previous treatment (particularly radiation exposure), size of lesion, and proximity to critical structures.
  
  
  CONCLUSIONS
  Rapid and significant pain relief was achieved after stereotactic radiosurgery in 32 of 34 treated tumors. In patients treated for metastases, pain was relieved within 72 hours and remained reduced 3 months later. Pain relief was achieved with a single dose as low as 500 cGy. Spinal cord isodoses were less than 50% in all patients except those with intradural tumors (mean single dose to spinal cord 268 cGy and mean total dose to spinal cord 689 cGy). Two patients experienced transient radiculitis (both with a biological equivalent dose (BED) > 60 Gy). One patient who suffered multiple recurrences of a conus ependymoma had permanent neurological deterioration after initial improvement. Pathological evaluation of this lesion at surgery revealed radiation necrosis with some residual/recurrent tumor. No patient experienced other organ toxicity. Stereotactic radiosurgery of the spine is safe at the doses used and provides effective pain relief. In this study, BEDs greater than 60 Gy were associated with an increased risk of radiculitis.
authors.affiliation: Department of Neurosurgery, New York Medical College, Valhalla, New York 10595, USA. deborah_benzil@nymc.edu
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Benzil
authors.forename: Mehran
authors.initials: M
authors.lastname: Saboori
authors.forename: Alon Y
authors.initials: AY
authors.lastname: Mogilner
authors.forename: Ronald
authors.initials: R
authors.lastname: Rocchio
authors.forename: Chitti R
authors.initials: CR
authors.lastname: Moorthy
mesh_terms: D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009420:Nervous System / Q000503:physiopathology; D010166:Palliative Care; D011829:Radiation Dosage; D016634:Radiosurgery / Q000009:adverse effects; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000503:physiopathology / Q000556:secondary / Q000601:surgery*; D013131:Spine / Q000473:pathology; D013810:Therapeutic Equivalency