The effect of Simvastatin upon serum pseudocholinesterase and plasmatic factor VII.
The statins have a moderate lowering effect upon triglycerides, one hypothesis suggesting an inhibitory effect upon liver VLDL synthesis. Because VLDL synthesis is related to other hepatic protein synthesis we studied the effect of Simvastatin upon serum cholinesterase activity and factor VII activity, which are also synthetized at hepatic level.


METHODS
39 patients with ischaemic heart disease, proved by coronarography and moderate hypercholesterolaemia received for two months 20 mg Simvastatin (Zocor). The value of total Co, LDLCo, HDLCo, triglycerides, serum cholinesterase activity and factor VII activity were determined before and after treatment, by standard methods.


RESULTS
Triglycerides were, together with total Co, significantly lowered during the two months treatment with Simvastatin, but the values of serum cholinesterase and factor VII activity were not significantly modified. This suggests that moderate doses of Simvastatin do not depress liver protein synthesis.


CONCLUSIONS
Simvastatin does not lower the triglycerides level through depression of liver protein syntesis, other mechanisms being probably involved.
Zdrenghea
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Department of Cardiolology, Rehabilitation Hospital, University of Medicine, 46-50, Viilor Str., 3400 Cluj-Napoca, Romania.
Bodizs
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Predescu
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Oprea
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Zdrenghea
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D000328:Adult; D000368:Aged; D002091:Butyrylcholinesterase / Q000097:blood / Q000187:drug effects*; D005167:Factor VII / Q000032:analysis / Q000187:drug effects*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D019821:Simvastatin / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014280:Triglycerides; D005167:Factor VII; D019821:Simvastatin; D002091:Butyrylcholinesterase