DNA replication: stalling a fork for imprinting and switching.
Mating-type switching in fission yeast has long been known to be directed by a DNA 'imprint'. This imprint has now been firmly characterized as a protected site-specific and strand-specific nick. New work also links the widely conserved Swi1-Swi3 complex to the protection of stalled replication forks in general.
Egel
Richard
R
Department of Genetics, University of Copenhagen, Øster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark. richard.egel@molbio.ku.dk
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004261:DNA Replication / Q000502:physiology*; D004268:DNA-Binding Proteins; D005800:Genes, Fungal / Q000235:genetics*; D049770:Genes, Mating Type, Fungal; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D012568:Schizosaccharomyces / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C078562:SWI1 protein, S cerevisiae; C072981:SWI3 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C513096:swi1 protein, S pombe