Non-small-cell lung cancer: multimodality approach in stage-III resectable disease.
The long-term results of surgery +/- radiotherapy in patients with operable disease of locally advanced non-small-cell lung cancer are discouraging. In the vast majority, disseminated microscopic disease, resulting in the later occurrence of distant metastases, contributes substantially to this poor long-term outcome. The further development of multimodality treatment approaches in randomised trials, including effective systemic therapy, is necessary. These approaches and the current status of multimodality treatment strategies of resectable locally advanced non-small-cell lung cancer are discussed.
Thomas
Michael
M
Department of Hematology, Medical Oncology and Respiratory Medicine, University of Münster, Albert-Schweitzer Str. 33, D-48129 Münster, Germany. mthomas@uni-muenster.de
Hoffknecht
Petra
P
Droege
Cornelia
C
Baisch
Andreas
A
Reinmuth
Niels
N
Kreuter
Michael
M
Lange
Tobias
T
Berdel
Wolfgang E
WE
D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D009367:Neoplasm Staging