title: Angiogenic response induced by acellular aortic matrix in vivo.
abstract: In this study, we investigated the angiogenic response induced by acellular aortic matrices implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. Results showed that acellular matrices were able to induce a strong angiogenic response comparable to that of fibroblast growth factor 2 (FGF-2), a well-known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF-2 or transforming growth factor beta 1 (TGF-beta1) were added to the matrices and inhibited by the addition of an anti-FGF-2 or anti-TGF-beta1 antibodies. The response may be considered dependent on a direct angiogenic effect exerted by the matrices and in part also by the presence of FGF-2 and TGF-beta1 in the acellular matrices.
authors.affiliation: Department of Pharmaceutical Sciences, University of Padua, Padua, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Conconi
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nico
authors.forename: Domenica
authors.initials: D
authors.lastname: Mangieri
authors.forename: Mara
authors.initials: M
authors.lastname: Tommasini
authors.forename: Rosa
authors.initials: R
authors.lastname: di Liddo
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Parnigotto
authors.forename: Gastone G
authors.initials: GG
authors.lastname: Nussdorfer
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D016222:Fibroblast Growth Factor 2 / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D013552:Swine; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000276:immunology / Q000494:pharmacology; D053773:Transforming Growth Factor beta1; D019737:Transplants
chemical_list: D043925:Angiogenesis Inducing Agents; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2