Synthesis and in vitro evaluation of new azaphenylalanine derivatives as serine protease inhibitors.
New inhibitors of serine proteases with azaphenylalanine scaffold were synthesized and their activity was evaluated in vitro. We studied the effect of different substituents in the part of a molecule that binds in the distal pocket of the thrombin active site. Modifications generally led to decreased activity, however two derivatives are promising lead compounds as new thrombin and dual thrombin-factor Xa inhibitors.
Obreza
A
A
Faculty of Pharmacy, University of Ljubljana, Slovenia.
Stegnar
M
M
Trampus-Bakija
A
A
Prezelj
A
A
Urleb
U
U
D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors
C493948:5-amino-1 ,2,4-thiadiazol-3(2H)-one; D007202:Indicators and Reagents; D015842:Serine Proteinase Inhibitors; D013830:Thiadiazoles; C493947:azaphenylalanine; D010649:Phenylalanine; D013917:Thrombin