title: A new immune-competent animal model of mucosally derived squamous cell carcinoma.
abstract: OBJECTIVE
  To develop an immune-competent animal model for mucosally derived squamous cell carcinoma (SCCA).
  
  
  METHODS
  Fifteen Fischer 344 rats were inoculated with 1, 2, 5, 10, or 20 x 10(6) FAT7 cells in their flanks. The animals were observed for tumor growth and metastasis.
  
  
  RESULTS
  All animals developed tumors that grew exponentially. Pulmonary metastases developed in all animals and 13% developed lymph node metastases.
  
  
  CONCLUSIONS
  The FAT7 flank tumor in Fischer 344 rats is a new animal model that closely resembles the behavior of human mucosal head and neck cancer.
  
  
  CONCLUSIONS
  The existence of an immune-competent, mucosally derived, and reliable animal model of SCCA that somewhat resembles human head and neck SCCA gives the opportunity to perform immune-modulating experiments on head and neck cancer in these animals.
  
  
  METHODS
  B-3.
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Hamid R
authors.initials: HR
authors.lastname: Djalilian
authors.forename: Khashayar
authors.initials: K
authors.lastname: Lessan
authors.forename: Vahid
authors.initials: V
authors.lastname: Grami
authors.forename: Stefan E
authors.initials: SE
authors.lastname: Pambuccian
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Spellman
authors.forename: Walter C
authors.initials: WC
authors.lastname: Low
authors.forename: Walter A
authors.initials: WA
authors.lastname: Hall
authors.forename: Frank G
authors.initials: FG
authors.lastname: Ondrey
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000096:biosynthesis; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism*; D007121:Immunocompetence; D023421:Models, Animal; D009154:Mutation; D009297:Nasal Mucosa; D051381:Rats; D016211:Transforming Growth Factor alpha / Q000096:biosynthesis
chemical_list: D016211:Transforming Growth Factor alpha; D066246:ErbB Receptors