title: Relation between bone marrow angiogenesis and serum levels of angiogenin in patients with myelodysplastic syndromes.
abstract: Angiogenesis is implicated in the progression of myelodysplastic syndromes (MDS). Bone marrow microvascular density (MVD), serum angiogenin (ANG) and interleukin 6 (IL-6) were measured in 67 patients with untreated MDS. MVD, ANG and IL-6 were significantly higher in the patient group as a whole when compared to controls (P < 0.01). MVD and ANG were significantly higher in subtypes with a high-risk for leukemic transformation (RAEB, RAEB-t and CMML) than in low-risk subtypes (RA and RARS) (P < 0.01). In the MDS group, a positive correlation was found between ANG and IL-6 (P < 0.001) and also between MVD and IL-6 (P < 0.05). Using multivariate analysis, only IL-6 displayed independent prognostic value and was inversely related to MDS survival.
authors.affiliation: Department of Haematology, University Hospital of Heraklion, Medical School of Crete, P.O. Box 1352, Heraklion, Crete, Greece. freda@med.uoc.gr
authors.forename: Michael G
authors.initials: MG
authors.lastname: Alexandrakis
authors.forename: Freda H
authors.initials: FH
authors.lastname: Passam
authors.forename: Constantina A
authors.initials: CA
authors.lastname: Pappa
authors.forename: Katerina
authors.initials: K
authors.lastname: Sfiridaki
authors.forename: George
authors.initials: G
authors.lastname: Tsirakis
authors.forename: John
authors.initials: J
authors.lastname: Damilakis
authors.forename: Efstathios N
authors.initials: EN
authors.lastname: Stathopoulos
authors.forename: Despina S
authors.initials: DS
authors.lastname: Kyriakou
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000098:blood supply*; D018450:Disease Progression; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000401:mortality; D009389:Neovascularization, Pathologic; D011379:Prognosis; D012259:Ribonuclease, Pancreatic / Q000097:blood*; D012306:Risk; D016019:Survival Analysis
chemical_list: D015850:Interleukin-6; C046366:angiogenin; D012259:Ribonuclease, Pancreatic