Decreases in glucocorticoid sensitivity as a factor of stress-producing changes in the activity of monoamine oxidase, lipid peroxidation, and behavior in rats.
Four episodes of immobilization stress induced a decrease in the sensitivity of rats to glucocorticoid hormones, which was accompanied by anxiogenic behavior, increased MAO-B activity, and a parallel increase in lipid peroxidation (LPO) in brain tissues. There was a simultaneous increase in MAO-B activity in the kidneys and accumulation of LPO products in the liver and kidneys. Administration of Kenalog (2 mg/kg), a pharmacological analog of glucocorticoid hormones, prevented the poststress activation of MAO-B and LPO and decreased the extent of anxiogenic behavioral abnormalities in rats.
Volchegorskii
I A
IA
Department of General and Bioorganic Chemistry, Chelyabinsk State Medical Academy.
Tseilikman
V E
VE
Smirnov
D S
DS
Ship
S A
SA
Borisenkov
A V
AV
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012149:Restraint, Physical / Q000379:methods; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000201:enzymology / Q000503:physiopathology; D014222:Triamcinolone Acetonide / Q000494:pharmacology
D005938:Glucocorticoids; D008995:Monoamine Oxidase; D014222:Triamcinolone Acetonide