Oxidative aggression in atherosclerosis associated to degenerative psychoorganic disturbances.
We had in view the effect of the oxidative aggression as determinant factor in atherogenic process associated with degenerative psychoorganic disturbances. It was studied a group of old people distributed in two subgroups: a) 51 old people with atherosclerosis (AS) and b) 57 old people with atherosclerosis associated with degenerative psychoorganic disturbances determined by chronic ethylism. The results were compared to those of a 40 healthy adults group. Concomitantly, it were evaluated the supervened modifications in the antioxidant defense systems of the organism, by determining both of some nonenzymatic defense system components (reduced glutathione, ceruloplasmine and transferrin) and of some enzymatic defense system components (superoxide dismutase, catalase and glutathione peroxidase). The obtained results emphasize an important aggression exerted by the lipid peroxides against the old people organism, aggression that is amplified by the chronic ethylism with appearance of the degenerative psychoorganic disturbances. Generally, the antioxidant defense capacity of the old people organism is depressed, especially in the group with atherosclerosis associated with degenerative psychoorganic disturbances engendered by excessive and chronic alcohol intake.
Serban
M
M
University of Medicine and Pharmacy "Carol Davila" Bucharest, Department of Pathophysiology and Immunology, "Prof. dr. Al. Obregia" Hospital, 10, Sos. Berceni, Bucharest.
Ghiea
Viorica
V
Păsărică
Daniela
D
D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D020268:Alcohol-Induced Disorders, Nervous System / Q000209:etiology* / Q000503:physiopathology; D001161:Arteriosclerosis / Q000150:complications* / Q000503:physiopathology; D000431:Ethanol / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology
D000431:Ethanol