title: [The endocrine mask of a developing process of schizophrenia--case study].
abstract: In this research psychic and somatic symptoms related to disturbances of hypothalamus-hypophysis-peripheral regulation which may occur in the schizophrenic process were analysed. Authors discussed the problem of relations between hypothalamus neuroregulation and pathogenesis of endocrine disturbances which suggest the organic cause of obesity, hirsutism and secondary amenorrhea among women diagnosed with paranoid schizophrenia. Actual antipsychotic pharmacological treatment, including some side-effects: the metabolic (obesity) and the endocrine (hyperprolactinemia) ones were considered. The authors conclude that endocrine disorders which are connected with hypothalamus disfunction (sleeping, eating and reproductive functions) may reach the psychotic symptoms and treating them influences at the same time some endocrine changes. The estimation of PRL release in a test of stimulation with metoclopramide can be a sensitive (though not specific) test of dopaminergic activity in tuberous--infundibulum pathway and may be used to control the treatment.
authors.affiliation: Katedry i Kliniki Psychiatrii w Szczecinie.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Smiarowska
authors.forename: Barbara
authors.initials: B
authors.lastname: Krzyzanowska-Swiniarska
authors.forename: Agata
authors.initials: A
authors.lastname: Lisiecka
authors.forename: Magdalena
authors.initials: M
authors.lastname: Letkiewicz
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pilarska
authors.forename: Jan
authors.initials: J
authors.lastname: Horodnicki
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D004700:Endocrine System Diseases / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D009765:Obesity / Q000209:etiology; D012563:Schizophrenia, Paranoid / Q000175:diagnosis* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents