title: Circulating white blood cell count correlates with left ventricular indices independently of the extent of risk area for myocardial infarction after successful reperfusion.
abstract: OBJECTIVE
  To test the hypothesis that the circulating white blood cell (WBC) and neutrophil counts are related to left ventricular (LV) indices in patients with the same risk area for acute myocardial infarction (AMI), we examined 100 consecutive AMI patients who had the culprit lesion at segment 6 according to the American Heart Association classification and who underwent successful direct coronary angioplasty.
  
  
  RESULTS
  The LV ejection fraction (LVEF), end-systolic volume (LVESVI) and end-diastolic volume index (LVEDVI) were obtained by left ventriculography performed 4 weeks after AMI onset. Univariate analysis disclosed that the counts of WBC and neutrophils on admission, and the maximal WBC count correlated negatively with LVEF (r = -0.46, p < 0.001; r = -0.54, p < 0.001 and r = -0.40, p < 0.001, respectively) and positively with LVESVI (r = 0.43, p < 0.001; r = 0.55, p < 0.001, and r = 0.30, p < 0.01, respectively). The counts of WBC and neutrophils on admission also correlated with LVEDVI (r = 0.28, p < 0.01 and r = 0.41, p < 0.001, respectively). Multivariate analysis with other clinical and angiographic factors revealed that the counts of WBC and neutrophils on admission correlated with LVEF (partial correlation coefficient, r = -0.37, p < 0.001 and r = -0.52, p < 0.001, respectively), with LVESVI (r = 0.34, p < 0.01 and r = 0.56, p < 0.001, respectively) and with LVEDVI (r = 0.28, p < 0.01 and r = 0.44, p < 0.001, respectively). The maximal WBC count also correlated with LVEF and LVESVI (r = -0.40, p < 0.001 and r = 0.21, p < 0.05, respectively).
  
  
  CONCLUSIONS
  The present study revealed that the circulating WBC count correlated with function and volume of the successfully reperfused LV after AMI in patients with the same risk area for AMI, indicating that the WBC count needs to be taken into consideration as an independent factor affecting the LV indices.
authors.affiliation: Department of Medicine and Medical Science, Okayama University Graduates School of Medicine and Dentistry, Okayama, Japan.
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Uesugi
authors.forename: Kohichiro
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Murakami
authors.forename: Keizo
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Shozo
authors.initials: S
authors.lastname: Kusachi
authors.forename: Takashi
authors.initials: T
authors.lastname: Murakami
authors.forename: Masanari
authors.initials: M
authors.lastname: Obika
authors.forename: Shigeshi
authors.initials: S
authors.lastname: Kamikawa
authors.forename: Toru
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shiratori
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy*; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy; D015425:Myocardial Reperfusion; D018570:Risk Assessment; D013318:Stroke Volume