title: [Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata].
abstract: OBJECTIVE
  To investigate the effects of ultra-fine powder technique on dissolution rates of the components in Andrographis paniculata.
  
  
  METHODS
  High performance liquid chromatography was employed to determine the concentration of andrographolide and dehydroandrographolide in common powdered or ultra-fine powdered Andrographis paniculata.
  
  
  RESULTS
  The dissolution rates of andrographolide and dehydroandrographolide in ultra-fine powdered Andrographis paniculata were higher than those of the general powder.
  
  
  CONCLUSIONS
  Ultra-fine powder technique promotes the dissolution rates of andrographolide and dehydroandrographolide.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China. rongliq@hotmail.com
authors.forename: Rong-Li
authors.initials: RL
authors.lastname: Qiu
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Zhang
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Chen
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000032:analysis*; D011208:Powders
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D011208:Powders; C030419:andrographolide; C478098:dehydroandrographolide