The effect of polyamidoamine dendrimers on human erythrocyte membrane acetylcholinesterase activity.
Polyamidoamine (PAMAM) dendrimers impact on activity of acetylcholinesterase was studied. It has been shown that dendrimers induce a biphasic effect: depending on their concentrations they increase or decrease enzyme activity. It may be due to two types of interactions: direct--between dendrimers and the enzyme; indirect--via a modification of the physical state of membrane phospholipids affecting the acetylcholinesterase.
Klajnert
B
B
Department of General Biophysics, University of Lodz, 12/16 Banacha St., 90-237 Lodz, Poland.
Sadowska
M
M
Bryszewska
M
M
D000110:Acetylcholinesterase / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000201:enzymology*; D006801:Humans; D009757:Nylons / Q000494:pharmacology*
D009757:Nylons; D000110:Acetylcholinesterase