title: Is the new definition of bronchopulmonary dysplasia more useful?
abstract: OBJECTIVE
  To determine the incidence of bronchopulmonary dysplasia (BPD) in low birth weight (LBW) infants <1251 g managed with early bubble nasal continuous positive airway pressure (NCPAP) and a gentle ventilation strategy using the newly proposed definition for BPD and the previous definitions.
  
  
  METHODS
  Needs for supplemental oxygen and positive pressure (positive pressure ventilation or NCPAP) during initial hospitalization were evaluated in 266 inborn LBW infants (birth weight <1251 g). The data were categorized in three weight groups, <751, 751 to 1000 and 1001 to 1250 g and the incidence of BPD was computed in survivors based on oxygen need at 28 days, 36 weeks postmenstrual age (PMA) and the new severity of BPD criteria, that is, mild BPD: need for supplemental oxygen > or =28 days, but not at 36 weeks PMA; moderate BPD: need for supplemental oxygen > or =28 days and <30% at 36 weeks PMA and severe BPD: need for supplemental oxygen > or =28 days, and >30% at 36 weeks PMA and/or positive pressure at 36 weeks PMA. Further, BPD-associated comorbidities and short-term outcome data during hospitalization were compared among the groups, defined by severity of BPD.
  
  
  RESULTS
  Among LBW infants <1251 g, the incidences of BPD at 28 days and 36 weeks PMA were 21.1 and 7.4% respectively. Using the newly defined criteria, the incidences of mild, moderate and severe BPD were 13.5, 4.8 and 2.6%, respectively. In total, 64.6% of these infants had mild BPD and 70.8% weighed <751 g at birth. Associated comorbidities correlated significantly with grades of underlying pulmonary disease. Also, significantly longer hospital stay, discharge at a higher PMA and lower growth velocity was observed with increasing grades of BPD.
  
  
  CONCLUSIONS
  The new system for grading the severity of BPD offers a better description of underlying pulmonary disease and correlates with the infant's maturity, growth and overall severity of illness. Whether it will have a role in predicting long-term outcome remains to be determined.
authors.affiliation: Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Sahni
authors.forename: Amer
authors.initials: A
authors.lastname: Ammari
authors.forename: Mandhir S
authors.initials: MS
authors.lastname: Suri
authors.forename: Vladana
authors.initials: V
authors.lastname: Milisavljevic
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Ohira-Kist
authors.forename: Jen T
authors.initials: JT
authors.lastname: Wung
authors.forename: Richard A
authors.initials: RA
authors.lastname: Polin
mesh_terms: D000367:Age Factors; D001997:Bronchopulmonary Dysplasia / Q000145:classification* / Q000175:diagnosis* / Q000453:epidemiology; D002657:Child Development; D045422:Continuous Positive Airway Pressure; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D010102:Oxygen Inhalation Therapy; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors