[The specific features of synthesis of heat shock proteins in patients with postinfarct cardiosclerosis].
The specific features of synthesis of inducible heat shock proteins with a molecular mass of 72 kDa (HSP72i) with peripheral lymphocytes were studied in patients with postinfarct cardiosclerosis and signs of chronic heart failure (CHF). According to the baseline level and time course of changes in lymphocytic accumulation of HSP72i during treatment, the patients with CHF were divided into 3 groups. Great differences were found in the course of CHF in patients with different levels of HSP72i synthesis. There were significant relationships between the content of HSP72i and the basic clinical, laboratory, and instrumental characteristics of CHF. The baseline level of HSP72i and the time course of changes in its accumulation by peripheral lymphocytes in patients with CHF were shown to be of prognostic value.
Drapkina
O M
OM
D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis*; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D011379:Prognosis
D006360:Heat-Shock Proteins