title: Unique amino acid polymorphisms of PrP genes in Mongolian sheep breeds.
abstract: To characterize amino acid polymorphisms of sheep prion protein (PrP) gene, DNA from 740 sheep of nine breeds raised in Mongolia was isolated and analyzed. A total of 16 genotypes and seven allelic variants of the PrP gene at codons 112, 136, 154, and 171 were found. The MARQ/MARQ genotype associated with susceptibility to scrapie was found in 82.6% of the sheep while the MARR/MARR genotype associated with resistance to scrapie was found in 1.8% of the sheep. The polymorphisms of valine and serine at codon 127, and leucine and arginine at codon 189 were detected in eight Mongolian sheep breeds, suggesting that these polymorphisms are a common feature among Mongolian sheep breeds.
authors.affiliation: Laboratory of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
authors.forename: Altangerel
authors.initials: A
authors.lastname: Gombojav
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Motohiro
authors.initials: M
authors.lastname: Horiuchi
authors.forename: Morikazu
authors.initials: M
authors.lastname: Shinagawa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005838:Genotype; D008986:Mongolia; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012756:Sheep / Q000235:genetics*; D013045:Species Specificity
chemical_list: D011328:Prions