Relation between bone marrow angiogenesis and serum levels of angiogenin in patients with myelodysplastic syndromes.
Angiogenesis is implicated in the progression of myelodysplastic syndromes (MDS). Bone marrow microvascular density (MVD), serum angiogenin (ANG) and interleukin 6 (IL-6) were measured in 67 patients with untreated MDS. MVD, ANG and IL-6 were significantly higher in the patient group as a whole when compared to controls (P < 0.01). MVD and ANG were significantly higher in subtypes with a high-risk for leukemic transformation (RAEB, RAEB-t and CMML) than in low-risk subtypes (RA and RARS) (P < 0.01). In the MDS group, a positive correlation was found between ANG and IL-6 (P < 0.001) and also between MVD and IL-6 (P < 0.05). Using multivariate analysis, only IL-6 displayed independent prognostic value and was inversely related to MDS survival.
Alexandrakis
Michael G
MG
Department of Haematology, University Hospital of Heraklion, Medical School of Crete, P.O. Box 1352, Heraklion, Crete, Greece. freda@med.uoc.gr
Passam
Freda H
FH
Pappa
Constantina A
CA
Sfiridaki
Katerina
K
Tsirakis
George
G
Damilakis
John
J
Stathopoulos
Efstathios N
EN
Kyriakou
Despina S
DS
D000368:Aged; D001853:Bone Marrow / Q000098:blood supply*; D018450:Disease Progression; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000401:mortality; D009389:Neovascularization, Pathologic; D011379:Prognosis; D012259:Ribonuclease, Pancreatic / Q000097:blood*; D012306:Risk; D016019:Survival Analysis
D015850:Interleukin-6; C046366:angiogenin; D012259:Ribonuclease, Pancreatic