title: The effect of two antidiarrhoeal drugs on the psychosocial adjustment to illness in chronic functional diarrhoea.
abstract: BACKGROUND
  Chronic functional diarrhea is an embarrassing symptom, causing the impairment of the quality of life.
  
  
  OBJECTIVE
  We looked for the effect of two antidiarrheal drugs, diosmectite and loperamide on the psychosocial adjustment to illness, a predictor for the health-related quality of life, in chronic functional diarrhea.
  
  
  METHODS
  Prospective controlled randomized trial including 50 consecutive patients with chronic functional diarrhea. They received either diosmectite 3 g b.i.d (n=25, 11M/14F, age 43+/-12 years) or loperamide 2 mg b.i.d. (n=25, 12M/13F, 47+/-11 years) for 2 weeks. Diarrhea and four other digestive symptoms were evaluated on a 0-16 scale, as well as patient's satisfaction (scale 1-10) and physician's satisfaction (scale 0-4). Psychosocial adjustment to illness was assessed with the PAIS-SR scale.
  
  
  RESULTS
  Symptom score for diarrhea was reduced from 10.5+/-5.7 to 2.6+/-1.2 (mean+/-SD), p<0.001 by diosmectite and from 8.5+/-4.2 to 1.2+/-0.6, p<0.0001 by loperamide. Diosmectite had a stronger effect than loperamide on accompanying pain (p<0.05) and bloating (p<0.01), but not on nausea, anorexia and emesis. The overall ratings of the patient's satisfaction (8.7+/-0.9 vs. 8.2+/-1.1, NS) and physician's satisfaction (3.2+/-0.3 vs. 3.1+/-0.4, NS) were similar. Psychological adjustment to illness was not changed for following items: health care orientation and domestic environment. Diosmectite improved more than loperamide the psychological distress (from 12.7+/-3.8 to 7.7+/-2.1 vs. 11.8+/-3.3 to 9.05+/-2.2, p<0.05), vocational environment (from 3.2+/-1.1 to 2.2+/-1.2 vs. 3.3+/-1.2 to 3.4+/-1.5, p<0.05) and sexual relationship scores (from 6.4+/-2.2 to 3.0+/-1.5 vs. 7.2+/-2.2 to 5.5+/-2.1, p<0.05). Both drugs similarly improved the items: family relationship and social environment.
  
  
  CONCLUSIONS
  Diosmectite and loperamide are both potent drugs for chronic functional diarrhea. Diosmectite has better effects on associated symptoms and some items of psychosocial adjustment to illness (distress, sexual activity and vocational environment).
authors.affiliation: 3rd Medical Department, Iuliu Hatieganu University of Medicine & Pharmacy, Cluj Napoca, Romania. ddumitrascu@cluj.astral.ro
authors.forename: D L
authors.initials: DL
authors.lastname: Dumitrascu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Stanculete
authors.forename: Ioana
authors.initials: I
authors.lastname: Mitrea
authors.forename: Diana Mihaela
authors.initials: DM
authors.lastname: Dumitrascu
authors.forename: Adriana
authors.initials: A
authors.lastname: Farcas
mesh_terms: D000328:Adult; D000930:Antidiarrheals / Q000627:therapeutic use*; D002908:Chronic Disease; D003967:Diarrhea / Q000188:drug therapy* / Q000523:psychology*; D005260:Female; D006801:Humans; D008139:Loperamide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D017640:Silicates / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D000930:Antidiarrheals; D017640:Silicates; D008139:Loperamide; C033214:Smectite