MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain.
We have evaluated the effect of the systemic administration of MK-801 (0.4 mg/kg) on the gene expression of D-amino acid oxidase (DAO) in several brain areas of the rat. The levels of DAO mRNA in all the brain areas significantly increased and peaked at 4 h after the administration. The present results suggest that there is a link between the expression of DAO mRNA and the N-methyl-D-aspartate (NMDA) receptor activity.
Yoshikawa
Masanobu
M
Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259-1143, Japan.
Oka
Tetsuo
T
Kawaguchi
Mitsuru
M
Hashimoto
Atsushi
A
D000818:Animals; D001921:Brain / Q000502:physiology*; D003605:D-Amino-Acid Oxidase / Q000235:genetics*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation / Q000187:drug effects
D018691:Excitatory Amino Acid Antagonists; D012333:RNA, Messenger; D016291:Dizocilpine Maleate; D003605:D-Amino-Acid Oxidase