title: Headache and inflammatory disorders of the central nervous system.
abstract: The subcommittee of the International Headache Society for headache classification (ICHD-II) has recently recognised that secondary headaches may occur in patients affected by inflammatory diseases (ID) of the central nervous system (CNS), classifying them among the headaches attributed to non-vascular intracranial disorders. The aim of the study was to verify the association between headache and inflammatory non-infectious diseases of the CNS, by a review of the literature data on the topic, integrated by personal cases and data. Secondary headaches may occur in four main disorders: neurosarcoidosis (sec 7.3.1), aseptic (non-infectious) meningitis (7.3.2), other non-infectious ID (7.3.3) and lymphocytic hypophysitis (7.3.4). Headache and/or primary headaches are frequently reported in patients with neurosarcoidosis (30%), Behcet's syndrome (BS) (55%) and acute disseminated encephalomyelitis (45-58%). Recent data show a high incidence of headache also in multiple sclerosis (MS) (58%) (not mentioned in ICHD-II). The association between headache and inflammatory dysimmune diseases of the CNS, in particular BS and MS, might suggest a pathogenetic relationship.
authors.affiliation: MS Centre, National Neurological Institute C. Besta, Via Celoria 11, I-20133 Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: La Mantia
authors.forename: A
authors.initials: A
authors.lastname: Erbetta
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications / Q000000981:diagnostic imaging; D004660:Encephalitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D004673:Encephalomyelitis, Acute Disseminated / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006261:Headache / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000000981:diagnostic imaging; D011859:Radiography; D012507:Sarcoidosis / Q000150:complications / Q000000981:diagnostic imaging