Mechanisms of action of pH-induced effects on vascular smooth muscle.
It is clear that pH has many effects on vascular smooth muscle and the overall action of pH on force will depend on the type of vascular smooth muscle in question and the combined effects on all the potential modulatory mechanisms. The major effects of pH on force appear to be mediated via modulation of [Ca]i rather than changes in the sensitivity of the contractile machinery to Ca2+. There are still numerous gaps in our understanding of the actions of pH and as more data become available, we will be able to better understand the major mechanisms involved.
Wray
Susan
S
The Physiological Laboratory, The University of Liverpool, Liverpool, UK. s.wray@liverpool.ac.uk
Smith
R D
RD
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D018118:Chloride Channels / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D009119:Muscle Contraction / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D015221:Potassium Channels / Q000378:metabolism; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases
D015220:Calcium Channels; D018118:Chloride Channels; D015221:Potassium Channels; D015544:Inositol 1,4,5-Trisphosphate; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases