title: Pan-cytokeratin immunoexpression in Wilms' tumors: a simple approach for understanding tumor epithelial differentiation.
abstract: Wilms' tumor is one of the most common solid tumors in children and is an interesting model for understanding the pathogenesis of embryonal tumors. Cytokeratins are intracellular fibrous proteins present in tissue of epithelial origin. The immunoexpression of the pan-cytokeratin AE1AE3 was studied in paraffin-embedded tissue sections from 24 Wilms' tumors (12 with nephrogenic rests) and also tissue samples from 15 corresponding normal kidneys, to evaluate epithelial differentiation in the genesis of Wilms' tumor. We observed that the intensity of the expression of AE1AE3 in the epithelial component of Wilms' tumors directly correlated with the degree of maturity of the epithelial structures correspondent to the collecting ducts.
authors.affiliation: Department of Pathology, Hospital do Câncer, São Paulo, Brazil. ssredni@childrensmemorial.org
authors.forename: Simone Treiger
authors.initials: ST
authors.lastname: Sredni
authors.forename: José Ivanildo
authors.initials: JI
authors.lastname: Neves
authors.forename: Beatriz
authors.initials: B
authors.lastname: de Camargo
authors.forename: Otávia Luiza Damas de
authors.initials: OL
authors.lastname: Caballero
authors.forename: Fernando Augusto
authors.initials: FA
authors.lastname: Soares
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D009396:Wilms Tumor / Q000378:metabolism / Q000473:pathology*
chemical_list: D007633:Keratins