title: Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure.
abstract: We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intraventricular pressure rise were significantly changed by carvedilol infusion as compared with the basal values in group N (normal rats), but not in group F. The left ventricular end-diastolic pressure was elevated, corresponding to the enhancement of the plasma norepinephrine (NE) concentration caused by carvedilol infusion, in group N. The enhancement of the plasma NE concentration induced by carvedilol administration in group F was higher than that in group N. The value for the maximal hypertensive effect of NE intravenous infusion (Emax) was decreased, and the plasma NE concentration at half-maximal effect (EC50) was increased in group F as compared with the values in group N. These results indicate that the SNS (presynaptic) activity is increased and that the SNS receptor sensitivity in the cardiovascular regulation system is decreased in heart failure.
authors.affiliation: Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Kamishinei-cho, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Abe
authors.forename: Kenichi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Shinji
authors.initials: S
authors.lastname: Sato
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nagai
authors.forename: Fadia A
authors.initials: FA
authors.lastname: Kamal
authors.forename: Mir I I
authors.initials: MI
authors.lastname: Wahed
authors.forename: Juan
authors.initials: J
authors.lastname: Wen
authors.forename: Gurusamy
authors.initials: G
authors.lastname: Narasimman
authors.forename: Meilei
authors.initials: M
authors.lastname: Ma
authors.forename: Palaniyandi
authors.initials: P
authors.lastname: Suresh
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tachikawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kashimura
authors.forename: Naohito
authors.initials: N
authors.lastname: Tanabe
authors.forename: Makoto
authors.initials: M
authors.lastname: Kodama
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Makoto
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Masao
authors.initials: M
authors.lastname: Kakemi
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000465:Algorithms; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000008:administration & dosage / Q000494:pharmacology*; D000077261:Carvedilol; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006333:Heart Failure / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood; D011412:Propanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D009638:Norepinephrine