title: Good fences make good neighbors: barrier elements and genomic regulation.
abstract: In the genome, it is essential to maintain a physical barrier between active and inactive regions; however, the nature of this barrier has been elusive. In a recent issue of Molecular Cell, West et al. (2004) shed light on mechanisms underlying these molecular "fences."
authors.affiliation: The Wistar Institute, Philadelphia, Pennsylvania 19014, USA.
authors.forename: Jumin
authors.initials: J
authors.lastname: Zhou
authors.forename: Shelley L
authors.initials: SL
authors.lastname: Berger
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D002645:Chickens; D002843:Chromatin / Q000378:metabolism*; D018983:DNA Footprinting; D004268:DNA-Binding Proteins / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D017353:Gene Deletion; D005786:Gene Expression Regulation; D016678:Genome; D005914:Globins / Q000235:genetics*; D051548:Histone Acetyltransferases; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D011496:Protein Methyltransferases; D034622:RNA Interference; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; D015534:Trans-Activators; D014157:Transcription Factors; D005914:Globins; D000076983:Histone Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D000123:Acetyltransferases; D051548:Histone Acetyltransferases