HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia.
OBJECTIVE
The purpose of our study was to evaluate the significance of polymorphisms in HLA class II genes in coronary artery ectasia (CAE) patients.


RESULTS
Twenty-six patients with CAE without associated cardiac defects were enrolled in the study. CAE was defined as luminal dilation of 1.5- to 2.0-fold of normal limits. Ninety-five healthy subjects who were donors for different organ transplantations, were chosen as control group. Physical examination, electrocardiography and chest X-ray were completely normal in these cases. Both the patients and the control group were screened and compared for their HLA class II genotypes. HLA-DR B1*13, DR16, DQ2 and DQ5 genotypes were significantly more frequent in the patient group. When the known risk factors of coronary heart disease were compared in the patients carrying these genotypes with the non-carrying group, no significant differences were encountered.


CONCLUSIONS
HLA-DR B1*13, DR16, DQ2 and DQ5 may be associated with the pathogenesis and increase the risk of CAE.
Akdemir
Ramazan
R
Abant Izzet Baysal University Düzce Faculty of Medicine Dept of Cardiology Konuralp Düzce, Turkey. rakdemir@yahoo.com
Ozhan
Hakan
H
Gunduz
Hüseyin
H
Erbilen
Enver
E
Yazici
Mehmet
M
Duran
Sadik
S
Orkunoglu
Funda
F
Albayrak
Sinan
S
Imirzalioglu
Necat
N
Uyan
Cihangir
C
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D003331:Coronary Vessels / Q000473:pathology*; D004108:Dilatation, Pathologic / Q000235:genetics; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains