Anticancerogenic effect of a novel chiroinositol-containing polysaccharide from Bifidobacterium bifidum BGN4.
Strains of bifidobacteria have many health-promotion effects. Whole cells or cytoplasm extracts of Bifidobacterium bifidum BGN4, isolated from human feces, inhibited the growth of several cancer cell lines. The polysaccharide fraction (BB-pol) extracted from B. bifidum BGN4 had a novel composition, comprising chiroinositol, rhamnose, glucose, galactose, and ribose. Three human colon cancer cell lines were treated with BB-pol: HT-29, HCT-116, and Caco-2. Trypan blue exclusion assay and BrdU incorporation assay showed that BB-pol inhibited the growth of HT-29 and HCT-116 cells but did not inhibit the growth of Caco-2 cells.
You
Hyun Ju
HJ
Department of Food Science and Nutrition, Seoul National University, Seoul 151-742, Republic of Korea.
Oh
Deok-Kun
DK
Ji
Geun Eog
GE
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001644:Bifidobacterium / Q000302:isolation & purification / Q000378:metabolism*; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003110:Colonic Neoplasms; D005243:Feces / Q000382:microbiology; D005690:Galactose / Q000032:analysis; D005947:Glucose / Q000032:analysis; D006801:Humans; D007294:Inositol / Q000032:analysis; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012210:Rhamnose / Q000032:analysis; D012266:Ribose / Q000032:analysis; D014343:Trypan Blue / Q000378:metabolism
D000970:Antineoplastic Agents; D011135:Polysaccharides, Bacterial; D007294:Inositol; D012266:Ribose; D001973:Bromodeoxyuridine; D014343:Trypan Blue; D005947:Glucose; D012210:Rhamnose; D005690:Galactose