Live attenuated influenza vaccine induces cross-reactive antibody responses in children against an a/Fujian/411/2002-like H3N2 antigenic variant strain.
Serum antibody titers against the A/Panama/2007/99(H3N2) and A/Fujian/411/2002(H3N2)-like viruses were determined in children 6-35 months of age who received either 1 dose of the inactivated influenza vaccine or the live attenuated influenza vaccine containing the A/Panama strain. Results indicated that the live vaccine induced higher antibody responses than the inactivated vaccine against the A/Panama and A/Fujian-like viruses.
Mendelman
Paul M
PM
MedImmune Vaccines, Mountain View, CA, USA.
Rappaport
Ruth
R
Cho
Iksung
I
Block
Stan
S
Gruber
William
W
August
Marilyn
M
Dawson
Denise
D
Cordova
Julie
J
Kemble
George
G
Mahmood
Kutubuddin
K
Palladino
Giuseppe
G
Lee
Min-Shi
MS
Razmpour
Ahmad
A
Stoddard
Jeffrey
J
Forrest
Bruce D
BD
D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007115:Immunization Schedule; D015994:Incidence; D007223:Infant; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000145:classification* / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D011336:Probability; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012737:Sex Factors; D018709:Statistics, Nonparametric; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000379:methods*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated