In vitro alpha amylase inhibitory effect of some clinically-used drugs.
Twenty six medicinal compounds used for treating various diseases and representing different chemical and pharmacological classes were tested for their potential alpha amylase inhibitory activity in vitro. Three of these (tetracycline, enalapril and captopril) were found to have a substantial alpha amylase inhibitory activity. The effect was shown to be dose dependent and the IC50 was determined (tetracycline = 0.59 mM, enalapril = 0.29 mM, and captopril = 0.78 mM) and compared to that of acarbose (0.0062 = mM). The potential pharmacological implications of this effect are discussed.
Hamdan
I I
II
Department of Pharmaceutical Sciences, University of Jordan, Amman, Jordan. iimad@hotmail.com
Afifi
F
F
Taha
M O
MO
D000465:Algorithms; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D000516:alpha-Amylases