title: A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar.
abstract: A new phenylbutenoid dimer, (+/-)- trans-3-(4-hydroxy-3-methoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (+/-)- trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3-diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including 1D and 2D NMR experiments.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, Korea.
authors.forename: Ah-Reum
authors.initials: AR
authors.lastname: Han
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Min
authors.forename: Tri
authors.initials: T
authors.lastname: Windono
authors.forename: Gwang-Ho
authors.initials: GH
authors.lastname: Jeohn
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Jang
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Seo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D027343:Rhizome; D030521:Zingiberaceae
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts