[Experimental study on treatment of minimal change nephropathy with niaozhuoqing].
OBJECTIVE
To study the therapeutic effect of niaozhuoqing on minimal change nephropathy (MCN) in rats.


METHODS
The MCN rat model was induced by intravenous injection of adriamycin. The effect of treatment on 24h urine protein, serum protein, lipid metabolism, malondialdehyde (MDA), superoxide dismutase (SOD) in serum, and renal histopathological changes were observed.


RESULTS
Niaozhuoqing could decrease the contents of proteinuria, blood lipid and MDA in serum, increase serum protein, SOD level and pathologically restore the glomeruli.


CONCLUSIONS
Niaozhuoqing has good effects on MCN, which probably related to decrease serum lipids level and reduce oxygen free radicals.
Li
Huanyu
H
Guangzhou Sanatorium of PLA, Guangzhou 510515.
Deng
Hongzhu
H
Wang
Caiyun
C
D000818:Animals; D004195:Disease Models, Animal; D004317:Doxorubicin; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007668:Kidney / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D009402:Nephrosis, Lipoid / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D004317:Doxorubicin