[Antimicrobial activity of new 4,4'-bipyridine derivatives: and in vitro study].
The antimicrobial and antifungal activity of some 4,4'-bipyridine derivatives were studied. The diffusimetric gelose surface diffusion method with stainless steel cylinders was used to study bacteria and Sabouraud fields for Candida albicans. Comparative analysis of the results led to the following conclusions. Diquaternary salts of 4,4'-bipyridinium possess a remarkable antimicrobial and antifungal activity. The influence of R1 and R2 substitutes in the para or meta position of the benzoylic radical affects selectivity but does not greatly influence activity.
Rotaru
A
A
Université Al. I. Cuza Iasi, Département de Chimie organique, B-dul. Carol I, No 11, Iasi-700506, Romania.
Ungureanu
M
M
Danac
R
R
Poeata
A
A
Druta
I
I
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D011725:Pyridines