Elevated voltage-gated Ca2+ channel immunoreactivities in the hippocampus of seizure-prone gerbil.
In present study, we investigated voltage-gated Ca2+ channel (VGCC) expressions in the hippocampus of the Mongolian gerbil and its association with different sequelae of spontaneous seizures, in an effort to identify the epileptogenesis in this animal. In the hippocampus of pre-seizure seizure sensitive (SS) gerbils, VGCC subunit expressions were significantly elevated, as compared with seizure-resistant (SR) gerbils. In 3 h postictal group, the alteration of VGCC expressions showed regional- and neuronal-specific manners; VGCC immunoreactivities in principal neurons were markedly decreased; however, their immunoreactivities in interneurons were significantly elevated. These results are the first comprehensive description of the distribution of VGCC immunoreactivities in the normal and epileptic hippocampus of gerbils, and suggest that these alterations in the hippocampus of the SS gerbil may be related with tissue excitability and have a role in modulating recurrent excitation following seizures.
Kang
Tae-Cheon
TC
Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do 200-702, South Korea. tckang@hallym.ac.kr
Kim
Duk-Soo
DS
Yoo
Ki-Yeon
KY
Hwang
In-Koo
IK
Kwak
Sung-Eun
SE
Kim
Ji-Eun
JE
Jung
Ju-Young
JY
Won
Moo Ho
MH
Suh
Jun-Gyo
JG
Oh
Yang-Seok
YS
D000818:Animals; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D020864:Calcium Channels, N-Type / Q000378:metabolism*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000378:metabolism* / Q000503:physiopathology; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology; D007150:Immunohistochemistry; D008297:Male; D015854:Up-Regulation
D020746:Calcium Channels, L-Type; D020864:Calcium Channels, N-Type