title: [Antiviral activity of different drugs in vitro against viruses of bovine infectious rhinotracheitis and bovine diarrhea].
abstract: In vitro experiments studied the antiviral activity of 11 different drugs against viruses of bovine infective rhinotracheitis (BIRT) and bovine viral diarrhea (BVD). The 50% inhibiting concentrations of the test agents were determined in the monolayers of MDBK and KCT cell cultures. Only did phosprenyl show a virucidal activity against BIRT virus. All the tested drugs significantly inhibited the reproduction of BIRT virus in the sensitive MDBK cell cultures. Thus, bromuridin, acyclovir, ribavirin and methisazonum inhibited the virus by > or = 100,000 times; liposomal ribavirin, gossypolum, anandinum, polyprenolum, phosprenyl, by 1000-10,000 times; eracond and argovit, by 100 times. In experiments on BVD virus, the cultured KCT cells displayed the antiviral activity of bromuridin, phosprenil, polyprenolum, methisazonum, acyclovir, gossypolum, argovit, and ribavirin (in two variants), which caused a statistically significant (100-10,000-fold) decrease in the productive activity of this virus. Eracond and anandid proved to be ineffective.
authors.forename: A G
authors.initials: AG
authors.lastname: Glotov
authors.forename: T I
authors.initials: TI
authors.lastname: Glotova
authors.forename: A A
authors.initials: AA
authors.lastname: Sergeev
authors.forename: T V
authors.initials: TV
authors.lastname: Belkina
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001976:Bromouracil / Q000031:analogs & derivatives; D002460:Cell Line; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects* / Q000254:growth & development; D007242:Herpesvirus 1, Bovine / Q000187:drug effects* / Q000254:growth & development; D008720:Methisazone / Q000494:pharmacology; D011106:Polyisoprenyl Phosphates / Q000494:pharmacology; D012254:Ribavirin / Q000494:pharmacology; D014529:Uridine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D011106:Polyisoprenyl Phosphates; C105485:phosprenyl; D012254:Ribavirin; D001976:Bromouracil; D008720:Methisazone; C006824:5-bromouridine; D014529:Uridine; D000212:Acyclovir