title: Effectiveness of propagermanium treatment in multiple myeloma patients.
abstract: Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the condition of four patients was stable (stable disease, SD). After discontinuation of propagermanium, the status of MM progressed in two patients who were in SD and in two patients who had achieved PR. The administration of propagermanium was restarted in one patient resulting in a decrease in her paraprotein.
authors.affiliation: Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan. rtsutsu@nyc.odn.ne.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Hiroe
authors.initials: H
authors.lastname: Kanamori
authors.forename: Mio
authors.initials: M
authors.lastname: Musashi
authors.forename: Hiina
authors.initials: H
authors.lastname: Minami
authors.forename: Arata
authors.initials: A
authors.lastname: Fukushima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yamato
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ehira
authors.forename: Takahito
authors.initials: T
authors.lastname: Kawamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Obara
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Ogura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Masauzi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005857:Germanium; D006801:Humans; D007369:Interferon Inducers / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D009194:Myeloma Proteins / Q000032:analysis; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011422:Propionates; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D007369:Interferon Inducers; D009194:Myeloma Proteins; D009942:Organometallic Compounds; D011422:Propionates; D005857:Germanium; C066750:propagermanium