A concise synthesis of spirotryprostatin A.
The preparation of two new synthons, 2,5- and 2,6-dibromotryptophan esters, and their use in diastereoselective intramolecular N-acyliminium ion spirocyclization methodology for the rapid construction of spirotryprostatin A and analogues are described.
Miyake
Fumiko Y
FY
Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA.
Yakushijin
Kenichi
K
Horne
David A
DA
D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D010879:Piperazines; D013141:Spiro Compounds; C478300:spirotryprostatin A