Relationship between performance on the Stroop test and N-acetylaspartate in the medial prefrontal cortex in deficit and nondeficit schizophrenia: preliminary results.
The aim of this research was to investigate the relationship between performance on the Stroop test and N-acetylaspartate/creatine assessed using proton magnetic resonance spectroscopy in the medial prefrontal cortex (MPFC) of schizophrenia patients. The Schedule for the Deficit Syndrome was used to subdivide the schizophrenia patients into deficit (n=5) and nondeficit (n=17) subtypes. Twenty-one control subjects served as a comparison group. A strong correlation between right-sided N-acetylaspartate/creatine levels and Stroop scores was found in the deficit patients but not in the nondeficit patients and the controls. This result suggests a relationship between a dysfunction of the right medial prefrontal cortex and a deficit in selective attention in schizophrenia patients with the deficit syndrome.
Delamillieure
Pascal
P
Groupe d'Imagerie Neurofonctionnelle, UMR 6194 CNRS, Centre Cyceron, Bd H. Becquerel and Centre Esquirol, Centre Hospitalier et Universitaire, Avenue Côte de Nacre, 14000 Caen, France. delamillieure-p@chu-caen.fr
Constans
Jean-Marc
JM
Fernandez
Jésus
J
Brazo
Perrine
P
Dollfus
Sonia
S
D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000503:physiopathology*; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D012720:Severity of Illness Index
D001224:Aspartic Acid; C000179:N-acetylaspartate