A recurrent chromosome 4 marker in primary squamous cell lung cancer.
A sample of eight primary lung tumors histologically identified as squamous cell type carcinomas (SQC) were cytogenetically analyzed after a short-term (7 days) culture. Several numerical and structural abnormalities were observed. As G-banding analysis is unable to fully characterize complex marker chromosomes, we applied the fluorescence chromosome painting technique to identify one as a marker derived from a chromosome 4 that has not been described until now. We found it in half of the analyzed cases.
Mimbacas
Adriana Beatriz
AB
Departamento de Citogenética, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia 3318, C.P. 11300 Montevideo, Uruguay. abmg@iibce.edu.uy
Cardoso
José Horacio
JH
D002871:Chromosome Banding; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D018307:Neoplasms, Squamous Cell / Q000235:genetics / Q000473:pathology*; D014407:Tumor Cells, Cultured
D005819:Genetic Markers