title: [Protective effect of tetramethylpyrazine and L-arginine on rats with acute myocardial infarction].
abstract: OBJECTIVE
  To compare the protective effects of tetramethylpyrazine (TMP) alone and TMP and L-arginine (TMP-LA) combination on rats with acute myocardial infarction (AMI), and to explore its mechanism.
  
  
  METHODS
  The rat model of AMI was established by via caudal vein injection of pituitrin. Experimental animal groups of normal, model, TMP treated and TMP-LA (via abdominal cavity and caudal vein respectively) treated groups were established. Expression of P- and E-selectin, serum creatine phosphokinase (CK) and troponin T (TnT), and marrow peroxidase (MPO) concentration in myocardial tissue were determined by immunohistochemical stain.
  
  
  RESULTS
  As compared with the normal group, serum CK and TnT level, and MPO concentration in myocardial tissue were significantly higher in the model group (P < 0.01), with P- and E-selectin significantly up-regulated (P < 0.01). As compared with the model group, the above-mentioned parameters in the TMP or TMP-LA treated group was significantly lower (P < 0.05).
  
  
  CONCLUSIONS
  Combined use of TMP and LA showed obvious synergism in treating AMI, by way of multi-link inhibition on expression of adhesive factors and decrease of leucocyte infiltration.
authors.affiliation: Department of Pathophysiology, Guiyang Medical College, Guiyang 550004. szj121@tom.com
authors.forename: Zhang-juan
authors.initials: ZJ
authors.lastname: Song
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Bao-luo
authors.initials: BL
authors.lastname: Li
mesh_terms: D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D003402:Creatine Kinase / Q000097:blood; D004357:Drug Synergism; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology; D019007:P-Selectin / Q000097:blood; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020107:Troponin T / Q000097:blood
chemical_list: D019007:P-Selectin; D011719:Pyrazines; D020107:Troponin T; D001120:Arginine; D003402:Creatine Kinase; C017953:tetramethylpyrazine