title: [Intervention effect of tongfei mixture on nocturnal hypoxia in patients with chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To study the effect of tongfei mixture (TFM, a Chinese recipe mainly consisted of angelica and rehmannia root) on nocturnal hypoxia in patients with chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  Sixty patients with COPD of remission phase were randomly divided into 3 groups, 20 in each group. Group A was the control group; Group B, the group simply treated with oxygen; Group C, treated with oxygen and TFM. Changes of pulmonary function, diaphragm muscle mobility (DMM), 6 min walk distance (6MWD), morning arterial blood gas, nocturnal lowest oxygen saturation (LSaO2), mean blood oxygen saturation (MSaO2), the percentage of saturation lower than 90% time account for total sleeping time (SLT90%) and ultrasonocardiogram before and after treatment were observed.
  
  
  RESULTS
  Levels of LSaO2, MSaO2 and SLT90% in Groups B and C were significantly higher than those in Group A (P<0.05, P<0.01). The lowering of PaCO2 in Group C was more significant than that in Group B (P<0.05). The mPAP level in Group C was lower, FEV1, 6MWD and DMM were improved than those in Group A and B, showing significant difference (P<0.05).
  
  
  CONCLUSIONS
  Combined use of oxygen therapy and TFM could not only improve the nocturnal hypoxia, but also lower PaCO2. TFM is an important supplement of oxygen therapy.
authors.affiliation: Department of Respiratory Medicine, Harrison International Peace Hospital, Hengshui, Hebei 053000. cuizhaobo@yahoo.com.cn
authors.forename: Zhao-bo
authors.initials: ZB
authors.lastname: Cui
authors.forename: Ya-dong
authors.initials: YD
authors.lastname: Yuan
authors.forename: Shu-hong
authors.initials: SH
authors.lastname: Liu
authors.forename: Dongliang
authors.initials: D
authors.lastname: Han
authors.forename: Xiuling
authors.initials: X
authors.lastname: Gao
authors.forename: Fucun
authors.initials: F
authors.lastname: Qi
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy* / Q000209:etiology; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D008517:Phytotherapy; D012890:Sleep / Q000502:physiology
chemical_list: D004365:Drugs, Chinese Herbal