title: Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome.
abstract: Acute respiratory distress syndrome (ARDS) has a high mortality and is associated with significant morbidity. Prior outcome studies have focused predominant on short-term outcomes (6-12 months). We assessed longitudinal neurocognitive, emotional, and quality of life in ARDS survivors at hospital discharge, and 1 and 2 years after hospital discharge using neuropsychologic tests and emotional and quality-of-life questionnaires. Neurocognitive sequelae occurred in 73% (54 of 74) of ARDS survivors at hospital discharge, 46% (30 of 66) at 1 year, and 47% (29 of 62) at 2 years. ARDS survivors report moderate to severe depression (16% and 23%) and anxiety (24% and 23%) at 1 and 2 years, respectively. The ARDS survivors had decreased quality of life, with the physical domains improving at 1 year, with no additional change at 2 years. Role emotional, pain, and general health did not change from hospital discharge to 2 years. Mental health improved during the first year and declined at 2 years. ARDS results in significant neurocognitive and emotional morbidity and decreased quality of life that persists at least 2 years after hospital discharge. ARDS can cause significant long-term, brain-related morbidity manifest by neurocognitive impairments and decreased quality of life.
authors.affiliation: Department of Critical Care Medicine, LDS Hospital, Eighth Avenue and C Street, Salt Lake City, UT 84602. ldrhopki@ihc.com
authors.forename: Ramona O
authors.initials: RO
authors.lastname: Hopkins
authors.forename: Lindell K
authors.initials: LK
authors.lastname: Weaver
authors.forename: Dave
authors.initials: D
authors.lastname: Collingridge
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Parkinson
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Chan
authors.forename: James F
authors.initials: JF
authors.lastname: Orme
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology* / Q000209:etiology; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D011788:Quality of Life / Q000523:psychology; D012128:Respiratory Distress Syndrome / Q000150:complications* / Q000523:psychology / Q000628:therapy; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology / Q000706:statistics & numerical data; D013997:Time Factors