[Autoimmune hepatitis in patients with a diagnosis of multiple sclerosis].
Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder associated with hypergammaglobulinemia and circulating autoantibodies. Two patients previously diagnosed with multiple sclerosis who developed AIH are reported. One patient showed acute presentation with fulminant hepatic failure requiring liver transplantation. Serum autoantibodies were negative in both patients but a characteristic clinical course in the first patient as well as the hepatic histological features with typical pathological changes of AIH in both patients and a score compatible with AIH established the diagnosis.
Núñez
O
O
Servicio de Aparato Digestivo, Sección de Hepatología, Hospital Gregorio Marañón, Madrid, Spain.
de Andrés
C
C
Alvarez
E
E
García-Monzón
C
C
Clemente
G
G
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D019693:Hepatitis, Autoimmune / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000276:immunology / Q000473:pathology*; D016031:Liver Transplantation; D009103:Multiple Sclerosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy
D001323:Autoantibodies; D007166:Immunosuppressive Agents