Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia.
Aleukemic leukemia cutis is a rare condition characterized by the invasion of leukemic blasts into the skin before their appearance in the peripheral blood. Leukemia cutis usually occurs in patients with myeloid leukemia, especially the myelomonocytic and monocytic types of acute myeloblastic leukemia. We describe the case of a 62-year-old woman with aleukemic leukemia cutis who developed Philadelphia-positive acute leukemia 1 month after skin involvement. Leukemic cells expressed both myeloid and B-cell lineage surface markers, and monoclonal rearrangement of the immunoglobulin heavy chain was detected by Southern blot analysis. This report is the first of a case of aleukemic leukemia cutis preceding Philadelphia-positive biphenotypic leukemia.
Onozawa
Masahiro
M
Departments of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. masahiro.onozawa@nifty.ne.jp
Hashino
Satoshi
S
Kanamori
Hiroe
H
Izumiyama
Koh
K
Yonezumi
Masakatsu
M
Chiba
Koji
K
Kondo
Takeshi
T
Fukuhara
Takashi
T
Tanaka
Junji
J
Imamura
Masahiro
M
Asaka
Masahiro
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology; D001752:Blast Crisis; D019070:Cell Lineage; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D022423:Myeloid Cells / Q000473:pathology; D010641:Phenotype; D010677:Philadelphia Chromosome; D018805:Sepsis
D007143:Immunoglobulin Heavy Chains