title: Does headache represent a clinical marker in early diagnosis of cerebral venous thrombosis? A prospective multicentric study.
abstract: The main aim of this study is to look for early clinical markers of cerebral venous thrombosis (CVT). As headache represents the major clinical manifestation at presentation we focused our attention on this symptom. We present the preliminary results of a prospective multicentric study that includes cases diagnosed as CVT in the participating centres. We have so far studied 35 patients (5 males and 30 females) from the ages of 18 to 78. The most frequent manifestation was headache (77.1%). It was more frequently localised (66.7%) and continuous (77.8%). The onset of pain was mostly acute-subacute (38.5%-50.0%) and the intensity moderate-severe (37.0%-51.9%). On univariate analysis, we found a positive correlation between CVT, acute headache onset (p=0.001) and severe headache (p=0.004). These preliminary results seem in accordance with our previous findings in the retrospective study, suggesting that CVT is more often associated with acute-onset headache of severe intensity.
authors.affiliation: Stroke Unit, Centro Cefalee, Clinica Neurologica, Università degli Studi Milano Bicocca, Ospedale San Gerardo, Via Donizetti 106, I-20052 Monza (MI), Italy.
authors.forename: S
authors.initials: S
authors.lastname: Iurlaro
authors.forename: E
authors.initials: E
authors.lastname: Beghi
authors.forename: N
authors.initials: N
authors.lastname: Massetto
authors.forename: A
authors.initials: A
authors.lastname: Guccione
authors.forename: M
authors.initials: M
authors.lastname: Autunno
authors.forename: B
authors.initials: B
authors.lastname: Colombo
authors.forename: T
authors.initials: T
authors.lastname: Di Monda
authors.forename: M
authors.initials: M
authors.lastname: Gionco
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
authors.forename: F
authors.initials: F
authors.lastname: Perini
authors.forename: F
authors.initials: F
authors.lastname: D'Onofrio
authors.forename: E
authors.initials: E
authors.lastname: Agostoni
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D005260:Female; D006261:Headache / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers