The expanding role of PSD-95: a new link to addiction.
One feature of addiction is the enhanced locomotor response known as behavioral sensitization that occurs with prolonged exposure to psychostimulants. In a recent study, Yao et al. have analyzed four distinct animal models that share this common phenotype. Evaluation of gene expression in the striatum reveals that postsynaptic density (PSD)-95, a synaptic scaffolding protein, is downregulated in each model, suggesting an essential role for this protein in addiction.
Roche
Katherine W
KW
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 2C903, Bethesda, MD 20892, USA. rochek@ninds.nih.gov
D000818:Animals; D016739:Behavior, Addictive / Q000378:metabolism*; D000076122:Disks Large Homolog 4 Protein; D005786:Gene Expression Regulation; D051528:Guanylate Kinases; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D013569:Synapses / Q000378:metabolism
D000076122:Disks Large Homolog 4 Protein; C501447:Dlg4 protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C033652:postsynaptic density proteins; D051528:Guanylate Kinases