title: [Genetic polymorphism of cytomegalovirus strains responsible of congenital infections].
abstract: OBJECTIVE
  Congenital Cytomegalovirus (CMV) infection is the main cause of neurological handicap in young children. The objective for studying genetic polymorphism of strains responsible for congenital infection is to identify CMV strains or groups of strains which would be more frequent in this context and/or which would be responsible for more severe congenital infection.
  
  
  METHODS
  In this paper, we report and analyze the literature concerning the genetic polymorphism of CMV strains responsible of congenital infection, in the genes coding for the envelop protein B and the non structural UL144 protein and in the CMV short tandem repeats.
  
  
  CONCLUSIONS
  All UL144 and gB genotypes can be vertically transmitted from mothers to fetuses, none of these studies has shown any link between the genotypes and the severity of congenital disease. Moreover, no link between short tandem repeats polymorphism and severity of congenital disease has been demonstrated. However, short tandem repeats analysis may be a powerful tool to study the epidemiology of CMV congenital infections.
authors.affiliation: Laboratoire de Virologie, EA 3620 Université René Descartes, CHU Necker-Enfants Malades, 149, rue de Sèvres, 75015 Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Picone
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Costa
authors.forename: Yves
authors.initials: Y
authors.lastname: Ville
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Chaix
authors.forename: Christine
authors.initials: C
authors.lastname: Rouzioux
authors.forename: Marianne
authors.initials: M
authors.lastname: Leruez-Ville
mesh_terms: D003587:Cytomegalovirus / Q000235:genetics* / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000151:congenital*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D014759:Viral Envelope Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014759:Viral Envelope Proteins; D014764:Viral Proteins