Syntheses, in vitro antibacterial and cytotoxic activities of a series of 3-substituted succinimides.
We have synthesized a series of 3-substituted succinimides and their in vitro antibacterial activities have been tested towards Gram-positive and Gram-negative bacteria from the ATCC collection. Some of them possess significant antibacterial activity against Gram-positive organisms (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212) but all are poorly active or inactive against Gram-negative organisms (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). The compounds with the lowest minimal inhibitory concentrations (esters of 3-hydroxy succinimides) are also the most cytotoxic against green monkey Vero cell line (ATCC CCL-81) and could explain that perhaps apoptosis should be implicated in eukaryotic cell cytotoxicity of succinimides.
Zentz
Frédéric
F
C.N.R.S., Chimie et Biologie des Substances Naturelles, 6, rue de l'Université, 29000 Quimper, France. zentz@iutquimp.univ-brest.fr
Le Guillou
Régis
R
Labia
Roger
R
Sirot
Danielle
D
Linard
Boris
B
Valla
Alain
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013388:Succinimides / Q000138:chemical synthesis / Q000494:pharmacology*; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D013388:Succinimides