[The activity of ethanol- and aldehyde-oxidizing enzymes of the brain in ethanol intoxication].
The distributed activity of alcohol dehydrogenase (ADG) and aldehyde dehydrogenase (AldDG) was histochemically studied in neurons of locus coeruleus, nuclei of raphe, substantia nigra and in cerebellar cortex in death or intoxication of ethanol (IE). The enzymatic activity was found to be changing depending on whether there was IE or not. Both higher ADG and lower AldDG were registered in the examined brain sections, which differ by mediatory structure of the neuronic centers. The detected regularities can be used within the forensic medical diagnosis of IE.
Morozov
Iu E
IuE
Kozlova
T V
TV
Mamedov
V K
VK
D000293:Adolescent; D000328:Adult; D000426:Alcohol Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D000435:Alcoholic Intoxication / Q000175:diagnosis* / Q000401:mortality; D000444:Aldehyde Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D002525:Cerebellar Cortex / Q000201:enzymology*; D015536:Down-Regulation; D000431:Ethanol / Q000506:poisoning*; D005260:Female; D005554:Forensic Medicine; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology*; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D015854:Up-Regulation
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase