Ruthenium-catalyzed [2 + 2] cycloadditions between bicyclic alkenes and alkynyl halides.
Ru-catalyzed [2 + 2] cycloadditions between norbornadiene and alkynyl halides were found to occur in moderate to good yields (32-89%). The presence of the halide moiety greatly enhances the reactivity of the alkyne component in the cycloaddition and can be transformed into a variety of products that are difficult or impossible to obtain via direct cycloaddition. [reaction: see text]
Villeneuve
Karine
K
Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Department of Chemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
Riddell
Nicole
N
Jordan
Robert W
RW
Tsui
Gavin C
GC
Tam
William
W