Determination of cobalt in pharmaceutical products.
The aim of this paper is to determine the content of cobalt in pharmaceutical products (B(12) vitamin powder, B(12) ampoules, Centrum, Spectrum ABC and Optima Forte) by spectrometric (FAAS, GFAAS and ICP-AES) and electrometric (AdSV) analytical techniques. The samples (approximately 0.5g) were treated with a mixture of 6mL HNO(3) and 1mL H(2)O(2) in the microwave oven. Due to the matrix effects the method of standard addition is preferred. The validity of the methods was tested by recovery studies of standard addition and results were found to be satisfactory.
Stoica
Anca-Iulia
AI
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest-3, Romania. anca_stoica2003@yahoo.com
Peltea
Mariana
M
Baiulescu
George-Emil
GE
Ionica
Mihai
M
D003035:Cobalt / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D014805:Vitamin B 12 / Q000032:analysis
D004364:Pharmaceutical Preparations; D003035:Cobalt; D014805:Vitamin B 12