title: Detection of alcohol consumption in suicides.
abstract: Screening instruments for detection of alcohol consumption, abuse, and dependence for use in psychological autopsy studies with case control design are not validated. Therefore, interrater and test-retest reliability of the Luebeck Alcohol Dependence and Abuse Screening Test (LAST) and the usability of this test for the psychological autopsy method were investigated. Alcohol consumption was evaluated by a semi-structured interview including the Structured Clinical Interview for DSM-IV Axis I (SCID-I) and the LAST in 163 completed suicides (mean age 49.6 +/- 19.3 years; 64.4% men) and by personal interview in 396 population-based controls (mean age 51.6 +/- 17.0 years; 55.8% men). Of the controls, 35 were additionally assessed by interviewing informants; these results were compared with those generated by personal interview. Comparison of LAST scores by personal and informant's interview of controls generated a Spearman correlation coefficient of 0.74 (P < 0.0001). The LAST (7 item-version, cut-off of 2) revealed high sensitivity and specificity for alcohol abuse and dependence, in both controls and suicides. LAST scores were significantly associated with high, frequent, and hazardous alcohol consumption (P < 0.001) in suicides. Our findings provide support for reliability and validity of identifying individuals with alcohol dependence and abuse obtained through the best-estimate method using the LAST. This 7-item questionnaire can be recommended as a useful tool for the psychological autopsy procedure in postmortem research.
authors.affiliation: Center of Psychiatry, Dept. of Psychiatry & Psychotherapy, Johann Wolfgang Goethe-University, Heinrich-Hoffmann-Str. 10, 60528 Frankfurt/Main, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Schneider
authors.forename: Axel
authors.initials: A
authors.lastname: Schnabel
authors.forename: Dieter
authors.initials: D
authors.lastname: Sargk
authors.forename: Konrad
authors.initials: K
authors.lastname: Maurer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Weber
authors.forename: Tilman
authors.initials: T
authors.lastname: Wetterling
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001344:Autopsy / Q000379:methods; D016022:Case-Control Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D000431:Ethanol / Q000032:analysis*; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013405:Suicide / Q000523:psychology
chemical_list: D000431:Ethanol