Cord blood transplantation for children with acute leukaemia: a Eurocord registry analysis.
OBJECTIVE
Report results of unrelated cord blood transplants collected by Eurocord Registry in children with acute leukemia.


RESULTS
Children with AML: 95 children were analyzed. The two year leukemia free survival was 42% in patients transplanted in first remission, 50% in second remission and 21% in children not in remission. Children with poor prognostic cytogenetic features had the same survival compared to other patients. Children with ALL: 195 patients with ALL were analyzed. The two year leukemia free survival was 36% in patients transplanted in remission and 15% in patients transplanted in relapse. Results of unrelated cord blood transplants compared to unrelated bone marrow transplants in children with acute leukemia: 416 children with acute leukemia received a HLA matched unrelated bone marrow transplant and were compared to 99 children transplanted with an unrelated HLA mismatched cord blood. The long term outcome between these groups were comparable with delayed engraftment in cord blood transplant, more relapse in T cell depleted bone marrow transplant and more GVH in the unmanipulated bone marrow transplant resulting in similar 5 years leukemia free survival.


CONCLUSIONS
These results show that use of unrelated cord blood transplant is an option in patients lacking an HLA identical sibling donor.
Gluckman
Eliane
E
Hematology-Bone Marrow Transplant Department and Eurocord Office, Hospital Saint Louis, Paris, France. eliane.gluckman@sls.ap-hop-paris.fr
Rocha
Vanderson
V
D016026:Bone Marrow Transplantation; D016022:Case-Control Studies; D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D005060:Europe; D006650:Histocompatibility Testing; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality* / Q000628:therapy; D012042:Registries