title: Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial.
abstract: Participants in the Age-Related Eye Disease Study were randomly assigned to receive daily antioxidants (vitamin C, 500 mg; vitamin E, 400 IU; beta carotene, 15 mg), zinc and copper (zinc, 80 mg; cupric oxide, 2 mg), antioxidants plus zinc and copper, or placebo. A cognitive battery was administered to 2,166 elderly persons after a median of 6.9 years of treatment. Treatment groups did not differ on any of the six cognitive tests (p > 0.05 for all). These results do not support a beneficial or harmful effect of antioxidants or zinc and copper on cognition in older adults.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, and San Francisco VA Medical Center, CA, USA.
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
authors.forename: Traci E
authors.initials: TE
authors.lastname: Clemons
authors.forename: Wendy L
authors.initials: WL
authors.lastname: McBee
authors.forename: Anne S
authors.initials: AS
authors.lastname: Lindblad
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000517:prevention & control*; D003300:Copper / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014810:Vitamin E / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use*; D019207:beta Carotene / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D014810:Vitamin E; D003300:Copper; D015032:Zinc; D001205:Ascorbic Acid