title: Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus.
abstract: The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from their mothers for 3h a day during postnatal days (PND) 10-15. At 16, 20, 30, and 60 days of age, the level of BDNF mRNA in the hippocampal formation of each group was determined using real-time PCR analysis. Early postnatal maternal deprivation of rat pups resulted in a significant increase in body weight at 60 days of age. The expression of BDNF mRNA in the hippocampus was significantly decreased at 16 days of age, and increased at 30 and 60 days of age. These data indicate that even a brief period of maternal deprivation during early postnatal life can affect hippocampal BDNF expression.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kuma
authors.forename: Takanori
authors.initials: T
authors.lastname: Miki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: He
authors.initials: H
authors.lastname: Gu
authors.forename: Hong-Peng
authors.initials: HP
authors.lastname: Li
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusaka
authors.forename: Irawan
authors.initials: I
authors.lastname: Satriotomo
authors.forename: Hanayo
authors.initials: H
authors.lastname: Okamoto
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Kuldip S
authors.initials: KS
authors.lastname: Bedi
authors.forename: Shoju
authors.initials: S
authors.lastname: Onishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suwaki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006624:Hippocampus / Q000254:growth & development* / Q000378:metabolism*; D008426:Maternal Deprivation; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019208:Brain-Derived Neurotrophic Factor