Angiotensin II and abdominal aortic aneurysms.
Abdominal aortic aneurysms (AAAs) have devastating effects on the morbidity and mortality of a large portion of the elderly population. Current therapeutic options for AAAs are limited to surgical approaches, because there are no proven pharmacologic treatments. Recently, there is evolving evidence that angiotensin II (Ang II) participates in the initiation and propagation of AAAs. Animal studies have consistently demonstrated the ability of Ang II to promote the formation of AAAs, although the mechanisms of this effect have not been defined. Further definition of the role of the renin-angiotensin system in AAA formation and progression will identify potential therapeutic strategies for treatment of this disease.
Daugherty
Alan
A
Division of Cardiovascular Medicine, 2 Graduate Center for Nutritional Sciences, Wethington Building, Room 521, Gill Heart Institute, University of Kentucky, Lexington, KY 40536-0200, USA. Alan.Daugherty@uky.edu
Cassis
Lisa
L
D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000188:drug therapy*; D006801:Humans; D051379:Mice
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II