[The influence of Bazhen decoction on hematopoietic modulator in anaemic mice].
This study was designed to evaluate the effect of Bazhen decoction on bone marrow depression induced by cyclophosphamide (CY) in mice. An experimental model of mouse bone marrow injury was established through cyclophosphamide induced and the following phenomena were observed. The techniques of culture of hematopoietic progenitor cell and hematopoietic growth factor assay were used. Bazhen decoction could obviously promote the proliferation of bone marrow cells of anaemic mice. The culture media of spleen cell, macrophage, lung and skeletal muscle treated with Bazhen decoction had much stronger stimulating effects on hematopoietic cells. The bone marrow cells of the anaemic mice could yield TNF through Bazhen decoction treatment. It was suggested that Bazhen decoction is clinically a hopeful drug used to cure bone marrow depression and attenuate the side effects of CY.
Chun
Ze
Z
College of Life Science, Sichuan University, Chengdu 610064, China.
Luo
Xia
X
Chen
Donghui
D
Yu
Mengyao
M
Cheng
Yaofeng
Y
Yang
Zhirong
Z
D000740:Anemia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D003520:Cyclophosphamide; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006410:Hematopoiesis / Q000187:drug effects*; D006413:Hematopoietic System / Q000187:drug effects; D051379:Mice; D008517:Phytotherapy; D048069:Tumor Necrosis Factors / Q000096:biosynthesis
D004365:Drugs, Chinese Herbal; D048069:Tumor Necrosis Factors; D003520:Cyclophosphamide