The impact of chromosome sorting and painting on the comparative analysis of primate genomes.
Chromosome sorting by flow cytometry is the main source of chromosome-specific DNA for the production of painting probes. These probes have been used for cross-species in situ hybridization in the construction of comparative maps, in the study of karyotype evolution and phylogenetics, in delineating territories in interphase nuclei, and in the analysis of chromosome breakpoints. We review here the contributions that this technology has made to the analysis of primate genomes.
Ferguson-Smith
M A
MA
Centre for Veterinary Science, University of Cambridge, Cambridge, United Kingdom. maf12@mole.bio.cam.ac.uk
Yang
F
F
Rens
W
W
O'Brien
P C M
PC
D000818:Animals; D020223:Chromosome Painting / Q000379:methods*; D033481:Chromosomes, Mammalian / Q000737:chemistry*; D005434:Flow Cytometry / Q000379:methods*; D016678:Genome; D006801:Humans; D011323:Primates / Q000235:genetics*