The factor VII activating protease G511E (Marburg) variant and cardiovascular risk.
A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a prothrombotic state. The current study has addressed risk for coronary heart disease in a prospective study of cardiovascular disorders (Northwick Park Heart Study II). An interactive effect upon risk was found between the 511E allele and elevated levels of cholesterol and triglyceride. Fibrinogen could substitute for triglyceride levels in this risk-interaction analysis. The findings support the proposal that the FSAP 511E allele exacerbates atherosclerosis or its clinical sequelae.
Ireland
Helen
H
Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London WC1E 6JF, UK. h.ireland@ucl.ac.uk
Miller
George J
GJ
Webb
Karen E
KE
Cooper
Jackie A
JA
Humphries
Steve E
SE
D000483:Alleles; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D005340:Fibrinogen / Q000032:analysis; D005838:Genotype; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011336:Probability; D011446:Prospective Studies; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D006113:United Kingdom / Q000453:epidemiology
D014280:Triglycerides; D005340:Fibrinogen; D002784:Cholesterol; C433550:HABP2 protein, human; D012697:Serine Endopeptidases