[Severe acute pancreatitis and abnormalities in blood coagulation and fibrinolysis system].
In acute pancreatitis, coagulo-fibrinolytic abnormalities may easily result in disseminated intravascular coagulation (DIC). The prognosis will become very poor, once bleeding necrosis or circulatory failure also occur in important internal organs other than the pancreas, leading to multiple organ failure. Changes in blood coagulation and fibrinolysis system may be greatly involved in the severity of acute pancreatitis. In medical treatment, it is necessary to be cautious of predictors of severity, and to perform the early diagnosis of DIC along with quick and positive intensive management.
Fujii
Tsutomo
T
Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya.
Nakao
Akimasa
A
D000208:Acute Disease; D001777:Blood Coagulation; D018450:Disease Progression; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005342:Fibrinolysis; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology; D010195:Pancreatitis / Q000097:blood* / Q000209:etiology*; D011486:Protein C / Q000502:physiology; D012720:Severity of Illness Index; D018180:Thrombomodulin / Q000502:physiology; D019851:Thrombophilia / Q000209:etiology
D011486:Protein C; D018180:Thrombomodulin