Interleukin-10 in viral diseases and cancer: exiting the labyrinth?
Interleukin-10 (IL-10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL-10 in chronic viral diseases and cancer. In the present review, we emphasize how these multiple roles define IL-10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens.
Vicari
Alain P
AP
Schering-Plough Laboratory for Immunological Research, Dardilly, France. alain.vicari@spcorp.com
Trinchieri
Giorgio
G
D001773:Blood Cells / Q000187:drug effects; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism* / Q000627:therapeutic use; D009369:Neoplasms / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014777:Virus Diseases / Q000188:drug therapy / Q000378:metabolism*
D016753:Interleukin-10