[Effect of shenqi fuzheng injection for assistance of chemotherapy in treating senile patients with non-small cell lung cancer].
OBJECTIVE
To study the effect of chemotherapy assisted with shenqi fuzheng injection (SFI) on senile patients with non-small cell lung cancer (NSCLC).


METHODS
One hundred and twenty old patients with NSCLC were treated with NP chemotherapeutic protocol, to the 60 patients in the treated group among them, additional medication of SFI was started one week before the beginning of chemotherapy. The short-term therapeutic efficacy, long-term survival rate, changes on quality of life (QOL) and immune function of patients, and hematological toxicity of therapy were observed.


RESULTS
Difference between the two groups on short-term therapeutic effect, 1- and 2-year survival rate showed no significance (P>0.05), but the 3-year survival rate in the treated group was 26.6%, while that in the control group was 11.7%, showed that the former was higher than the latter. After treatment QOL of the treated group was better than that of the control (P<0.05). Besides, the hematological toxicity and affection on immune function of chemotherapy after treatment in the treated group were all lower than those in the control group showing significant difference (P<0.05).


CONCLUSIONS
SFI has definite toxicity relieving effect on chemotherapy in treating senile NSCLC.
Liu
Cheng-lin
CL
Guangzhou Municipal Tumor Hospital, Clinical Research Center of Tumor, Guangzhou Medical College, Guangzhou 510095. liuguanghong@hotmail.com
Chen
Wei-ping
WP
Cui
Shu-zhong
SZ
Deng
Guangye
G
Liu
Liping
L
Qin
Lihong
L
Su
Xuchun
X
Yan
Bingchuan
B
Kong
Jiaxin
J
D000230:Adenocarcinoma / Q000188:drug therapy / Q000276:immunology; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000276:immunology; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007267:Injections; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011788:Quality of Life
D004365:Drugs, Chinese Herbal