title: Is laparoscopic adrenalectomy feasible for adrenocortical carcinoma or metastasis?
abstract: OBJECTIVE
  To review our experience with laparoscopic adrenalectomy (LA), to evaluate the effectiveness and safety of this procedure in patients with adrenal malignancy.
  
  
  METHODS
  The study included patients who underwent LA from 1995 to 2002, with histologically identified adrenocortical cancer (ACC) or metastasis. Indications for LA were adrenal masses with no radiological evidence of involvement of the surrounding structures, or solitary metastasis with well-controlled primary cancer. The variables evaluated were: size of the lesion, operative duration, estimated blood loss, intraoperative complications, local, port-site and intra-abdominal recurrence, distant metastasis, and survival time.
  
  
  RESULTS
  Fourteen malignant adrenal lesions in 205 LAs (7%) were confirmed with histological diagnoses that showed a primary ACC in six and metastasis in another seven (in one there was bilateral metastasis). The mean (sd) size of the malignant lesions was 5.9 (2.8) cm. The 12 unilateral procedures required a mean operative duration of 164 (47) min; the bilateral procedure lasted 215 min. There was one conversion to open surgery caused by local infiltration, whereas there were no intraoperative complications. The mean follow-up was 30 months, during which three patients died, one from endoperitoneal and trocar port-site seeding.
  
  
  CONCLUSIONS
  When the malignancy is confined to the adrenal gland, LA seems to be a feasible option if the principles of oncological surgery are respected. Nevertheless, further investigations are required to evaluate the appropriateness of this operation.
authors.affiliation: Division of Urology, Dipartimento di Scienze Cliniche e Biologiche, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy. porpiglia@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Porpiglia
authors.forename: Cristian
authors.initials: C
authors.lastname: Fiori
authors.forename: Roberto
authors.initials: R
authors.lastname: Tarabuzzi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Giraudo
authors.forename: Corrado
authors.initials: C
authors.lastname: Garrone
authors.forename: Mario
authors.initials: M
authors.lastname: Morino
authors.forename: Dario
authors.initials: D
authors.lastname: Fontana
authors.forename: Roberto M
authors.initials: RM
authors.lastname: Scarpa
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods*; D018268:Adrenocortical Carcinoma / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies