title: Molecular mechanisms and drug development in aquaporin water channel diseases: molecular mechanism of water channel aquaporin-2 trafficking.
abstract: Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. Besides the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signaling cascades also induce this sorting. Recently, AQP2-binding proteins that directly regulate this trafficking have been uncovered: SPA-1, a GTPase-activating protein (GAP) for Rap1, and cytoskeletal protein actin. This review summarizes recent advances related to the trafficking mechanism of AQP2 and its defect causing nephrogenic diabetes insipidus (NDI).
authors.affiliation: Department of Nephrology, Graduate School, Tokyo Medical and Dental University, Japan. ynodmed2@tmd.ac.jp
authors.forename: Yumi
authors.initials: Y
authors.lastname: Noda
authors.forename: Sei
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D051399:Aquaporin 2; D020346:Aquaporins / Q000235:genetics / Q000378:metabolism*; D018500:Diabetes Insipidus, Nephrogenic / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D009154:Mutation; D021381:Protein Transport / Q000502:physiology
chemical_list: C496023:AQP2 protein, human; D051399:Aquaporin 2; D020346:Aquaporins