title: Management of squamous cell carcinoma in a patient with recessive-type epidermolysis bullosa dystrophica.
abstract: BACKGROUND
  Surgical treatment of a recessive dystrophic epidermolysis bullosa patient is very difficult for both the surgeon and the anesthetist because of the fragility of the skin and abnormal nature of the tumor bed.
  
  
  OBJECTIVE
  We report a case of 54-year-old Japanese recessive dystrophic epidermolysis bullosa patient with squamous cell carcinoma (SCC) of the lateral malleolus.
  
  
  METHODS
  A tumor measuring 5.0 x 5.5 cm was surgically excised. The defect was then reconstructed by full-thickness skin grafting. To avoid airway complications, general anesthesia was administered using a face mask. Because the regional lymph nodes were swollen before surgery, the patient underwent sentinel lymph node biopsy.
  
  
  RESULTS
  The patient remains well with no sign of recurrence or metastasis 7 months after surgery.
  
  
  CONCLUSIONS
  To preserve activities of daily living, surgery should be performed for squamous cell carcinomas arising in recessive dystrophic epidermolysis bullosa patients.
authors.affiliation: Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Yamada
authors.forename: Naohito
authors.initials: N
authors.lastname: Hatta
authors.forename: Kana
authors.initials: K
authors.lastname: Sogo
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Komura
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takehara
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D016108:Epidermolysis Bullosa Dystrophica / Q000150:complications* / Q000235:genetics / Q000473:pathology; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery