title: [Longitudinal study of children with bronchopulmonary dysplasia treated with disodium cromoglycate].
abstract: In order to improve the quality of life of children born prematurely, who developed chronic lung disease, clinical trials of drugs of different origin are undertaken. The aim of the work was the evaluation of the efficacy of disodium cromoglycate in the treatment of bronchopulmonary dysplasia in children. We retrospectively studied 15 infants with bronchopulmonary dysplasia (BPD) hospitalised in the Infant Care Department of Children's Health Memorial Institute from 01.01.1997 to 01.02.2000. All babies were premature (25-30 weeks of gestation) with LBW or VLBW A control group of 11 babies with BPD, matched for birth weight and gestational age, who did not have disodium cromoglycate therapy were also studied. Recurrent obturative bronchitis and bronchial hyperresponsiveness were stated in all cases in both groups. Disodium cromoglycate was administered in all babies in the study group. Inhaled corticosteroid (Budesonide mite) was given in 10 cases, for a short period of time, due to severe obturative bronchitis. Babies in the control group were treated with systemic and inhaled corticosteroids. Results of our trial compared with the log-rank and chi2 test show statistically, significant differences in the regression of obturative bronchitis (log-rank = 4.35, p < 0.0001) and normalization of capillary blood-gas examination (log-rank = 3.777, p < 0.0002) in favour of the studied group, treated with disodium cromoglycate.
authors.affiliation: Klinika Niemowleca, Instytut "Pomnik Centrum Zdrowia Dziecka", Warszawa.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kassur-Siemieńska
authors.forename: Bogumiła
authors.initials: B
authors.lastname: Milewska-Bobula
authors.forename: Hanna
authors.initials: H
authors.lastname: Dmeńska
authors.forename: Mirosława
authors.initials: M
authors.lastname: Idzik
authors.forename: Anna
authors.initials: A
authors.lastname: Bauer
authors.forename: Paweł
authors.initials: P
authors.lastname: Marciński
authors.forename: Dorota
authors.initials: D
authors.lastname: Dunin-Wasowicz
authors.forename: Bozena
authors.initials: B
authors.lastname: Lipka
mesh_terms: D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy*; D016022:Case-Control Studies; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008137:Longitudinal Studies; D008297:Male; D010343:Patient Admission; D011247:Pregnancy; D047928:Premature Birth; D012189:Retrospective Studies
chemical_list: D018927:Anti-Asthmatic Agents; D004205:Cromolyn Sodium