title: Synthesis of dimeric trifluoromethoxyacridine-derived pathogen-inactivating nucleic acid intercalators.
abstract: A series of antiviral active compounds consisting of an intercalating acridine-derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. Thus, suitably mono-protected 1,omega-alkyldiamines gave, upon reaction with 9-chloro-2-trifluoromethoxyacridine, followed by deprotection and reaction with EDTA dianhydride, the target molecules. Incorporation of their Fe(II) complexes in the presence of ascorbate gave a reduction of the phage titer of MS2 phages by several logarithmic decades.
authors.affiliation: Institut für Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, D-06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de
authors.forename: René
authors.initials: R
authors.lastname: Csuk
authors.forename: Christian
authors.initials: C
authors.lastname: Raschke
authors.forename: Gunnar
authors.initials: G
authors.lastname: Göthe
authors.forename: Stefan
authors.initials: S
authors.lastname: Reissmann
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017909:Levivirus / Q000187:drug effects; D009696:Nucleic Acids / Q000187:drug effects
chemical_list: D000166:Acridines; D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D007364:Intercalating Agents; D009696:Nucleic Acids