title: The CCR5Delta32 allele is associated with reduced liver inflammation in hepatitis C virus infection.
abstract: CCR5Delta32 is a deletion mutation in the chemokine receptor CCR5. Liver inflammatory activity was found to be significantly reduced (P = 0.005) in Jewish Israeli patients infected with the hepatitis C virus (HCV) carrying the CCR5Delta32 allele. The CCR5Delta32 allele does not alter susceptibility to HCV infection; however, it may play a role in the progression and outcome of the disease.
authors.affiliation: Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Wald
authors.forename: O
authors.initials: O
authors.lastname: Pappo
authors.forename: Z B
authors.initials: ZB
authors.lastname: Ari
authors.forename: E
authors.initials: E
authors.lastname: Azzaria
authors.forename: I D
authors.initials: ID
authors.lastname: Wiess
authors.forename: I
authors.initials: I
authors.lastname: Gafnovitch
authors.forename: H
authors.initials: H
authors.lastname: Wald
authors.forename: U
authors.initials: U
authors.lastname: Spengler
authors.forename: E
authors.initials: E
authors.lastname: Galun
authors.forename: A
authors.initials: A
authors.lastname: Peled
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016174:Hepacivirus / Q000378:metabolism; D006526:Hepatitis C / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D008099:Liver / Q000378:metabolism* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D019713:Receptors, CCR5 / Q000235:genetics* / Q000378:metabolism
chemical_list: D019713:Receptors, CCR5