title: Severe sialadenitis: a new complication of drug reaction with eosinophilia and systemic symptoms.
abstract: BACKGROUND
  Drug cutaneous reaction and isolated cases of parotitis induced by terbinafine have been reported.
  
  
  METHODS
  We report a case of drug reaction with eosinophilia and systemic symptoms induced by terbinafine associated with a severe sialadenitis and a complete sicca syndrome. Evolution was protracted with a slow recovery of the rash but sicca syndrome persisted with only a very mild improvement at 6 months.
  
  
  CONCLUSIONS
  Liver, kidneys, lungs, and heart are the organs the most frequently involved in drug reaction with eosinophilia and systemic symptoms. Salivary and lacrimal glands can also be severely involved in the course of drug reaction with eosinophilia and systemic symptoms.
authors.affiliation: Departments of Dermatology, Hôpital Henri Mondor, Créteil, France.
authors.forename: Sophia
authors.initials: S
authors.lastname: Abecassis
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Roujeau
authors.forename: Hélène
authors.initials: H
authors.lastname: Bocquet
authors.forename: Christiane
authors.initials: C
authors.lastname: Copie-Bergman
authors.forename: Catherine
authors.initials: C
authors.lastname: Radier
authors.forename: Jean
authors.initials: J
authors.lastname: Revuz
authors.forename: Anne
authors.initials: A
authors.lastname: Cosnes
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009281:Naphthalenes / Q000009:adverse effects*; D012793:Sialadenitis / Q000139:chemically induced*; D012859:Sjogren's Syndrome / Q000139:chemically induced*; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine