title: Germacranolides from Calea urticifolia.
abstract: Four germacranolides, named calealactones A-C and calealactone B [corrected] were isolated from the leaves of Calea urticifolia (Compositae) in addition to three known germacranolides. Their structures were established on the basis of spectroscopic analysis including by 2D NMR spectroscopy. Calealactone C and 2,3-epoxyjuanisulamin displayed potent toxicity to U937 cells.
authors.affiliation: Development Section, Pharmaceuticals Department, Meiji Milk Product Co. Ltd., 1-26-11 Midori, Shimada-ku, Tokyo 130-8502, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamada
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
authors.forename: Hiroto
authors.initials: H
authors.lastname: Suzuki
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kurosaka
authors.forename: Naoko
authors.initials: N
authors.lastname: Hasegawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Ubukata
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D006801:Humans; D007938:Leukemia; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020298:U937 Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045788:Sesquiterpenes, Germacrane