title: Enantioselective allylic substitution of cinnamyl esters catalyzed by iridium-chiral aryl phosphite complex: conspicuous change in the mechanistic spectrum by a countercation and solvent.
abstract: Iridium-catalyzed asymmetric allylic alkylation of monoaryl substrates 4-6 with chiral phosphites 1-3 has been investigated. Although branched isomers were formed with high regioselectivities, the enantioselectivities of these products were remarkably influenced by solvents, countercations, and additives (ZnCl(2) and LiCl).
authors.affiliation: Medicinal Chemistry Research Institute, Otsuka Pharmaceutical Company, Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan.
authors.forename: Naosumi
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Karsten H
authors.initials: KH
authors.lastname: Marx
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tsubaki
authors.forename: Takeo
authors.initials: T
authors.lastname: Kawabata
authors.forename: Naohiko
authors.initials: N
authors.lastname: Yoshikai
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakamura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Fuji