title: Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis.
abstract: We investigated the serum macrophage migration inhibitory factor (MIF) levels of palmoplantar pustulosis patients, before and after the tonsillar provocation test. Higher serum MIF levels of palmoplantar pustulosis patients were decreased after the tonsillar provocation test (n=29). To confirm these phenomena, two patients with acute tonsillitis had their changes in body temperature, C-reactive protein (CRP) and serum MIF levels examined during the course of their illness. Surprisingly, increased MIF preceded fever and CRP elevation, and MIF subsequently decreased at the onset of fever and CRP elevation. Since MIF is an initiator of other proinflammatory cytokines, we suggest that the induction of MIF may precede other inflammatory conditions.
authors.affiliation: Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. michiki@med.hokudai.ac.jp
authors.forename: Tadamichi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hironori
authors.initials: H
authors.lastname: Niizeki
authors.forename: Osamu
authors.initials: O
authors.lastname: Takeuchi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Nobuko
authors.initials: N
authors.lastname: Inamoto
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Kusunoki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Riichiro
authors.initials: R
authors.lastname: Abe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimizu
authors.forename: Takeji
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hashiguchi
authors.forename: Jun
authors.initials: J
authors.lastname: Nishihira
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001831:Body Temperature; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis* / Q000097:blood*; D008297:Male; D008872:Microwaves; D008875:Middle Aged; D014066:Palatine Tonsil / Q000528:radiation effects*; D011565:Psoriasis / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014069:Tonsillitis / Q000097:blood* / Q000503:physiopathology
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D002097:C-Reactive Protein