title: [The practice guideline 'Photo(chemo)therapy and systemic therapy in severe chronic plaque-psoriasis'].
abstract: The guideline for the treatment of adults with moderate to severe chronic plaque-type psoriasis vulgaris is based on published scientific evidence. The efficacy of the treatment, its safety, the side effects, the patients' discomfort, the patients' preference and the costs of treatment and follow-up are listed as criteria that play a role in the choice of treatment. Photo(chemo)therapy is the treatment of choice for severe forms of psoriasis. Phototherapy with ultraviolet-B light (UVB), especially narrow-band UVB, is preferred above photochemotherapy with ultraviolet-A light and psoralenes (PUVA). Of the oral treatments, methotrexate and ciclosporin are preferred above retinoids and fumarates because they yield a higher percentage of patients with partial or nearly complete remission. Fumarates are not officially registered in The Netherlands and Belgium.
authors.affiliation: Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Dermatologie, Amsterdam.
authors.forename: Ph I
authors.initials: PI
authors.lastname: Spuls
authors.forename: M K
authors.initials: MK
authors.lastname: Tuut
authors.forename: J J E
authors.initials: JJ
authors.lastname: van Everdingen
authors.forename: M A
authors.initials: MA
authors.lastname: de Rie
mesh_terms: D016572:Cyclosporine / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D010778:Photochemotherapy / Q000191:economics / Q000379:methods*; D017410:Practice Guidelines as Topic; D011565:Psoriasis / Q000188:drug therapy* / Q000532:radiotherapy*; D012449:Safety; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000191:economics / Q000379:methods*
chemical_list: D003879:Dermatologic Agents; D016572:Cyclosporine; D008727:Methotrexate