The CCR5Delta32 allele is associated with reduced liver inflammation in hepatitis C virus infection.
CCR5Delta32 is a deletion mutation in the chemokine receptor CCR5. Liver inflammatory activity was found to be significantly reduced (P = 0.005) in Jewish Israeli patients infected with the hepatitis C virus (HCV) carrying the CCR5Delta32 allele. The CCR5Delta32 allele does not alter susceptibility to HCV infection; however, it may play a role in the progression and outcome of the disease.
Wald
O
O
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel.
Pappo
O
O
Ari
Z B
ZB
Azzaria
E
E
Wiess
I D
ID
Gafnovitch
I
I
Wald
H
H
Spengler
U
U
Galun
E
E
Peled
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016174:Hepacivirus / Q000378:metabolism; D006526:Hepatitis C / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D008099:Liver / Q000378:metabolism* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D019713:Receptors, CCR5 / Q000235:genetics* / Q000378:metabolism
D019713:Receptors, CCR5